Updated on 2024/04/19

写真a

 
KOH Hideo
 
Organization
Graduate School of Medicine Department of Basic Medical Science Lecturer
School of Medicine Department of Medical Science
Title
Lecturer
Affiliation
Institute of Medicine

Position

  • Graduate School of Medicine Department of Basic Medical Science 

    Lecturer  2022.04 - Now

  • School of Medicine Department of Medical Science 

    Lecturer  2022.04 - Now

Degree

  • Ph.D. ( Osaka City University )

Research Areas

  • Life Science / Hygiene and public health  / 分子疫学

  • Life Science / Hygiene and public health  / 生活習慣病の疫学

Research Interests

  • 生活習慣病

  • 予防医学

  • 疫学

Professional Memberships

  • 日本産業衛生学会

      Domestic

  • 日本疫学会

      Domestic

  • 日本内科学会

      Domestic

  • 日本血液学会

      Domestic

  • 日本造血・免疫細胞療法学会

      Domestic

Committee Memberships (off-campus)

  • 代議員   日本疫学会  

    2023.06 - Now 

  • 代議員   日本産業衛生学会  

    2022.11 - Now 

  • 評議員   日本血液学会  

    2020.09 - Now 

  • 作成グループ委員   日本臨床腫瘍学会・発熱性好中球減少症(FN)診療ガイドライン・改訂第3版WG  

    2021.03 - Now 

  • ガイドライン改定メンバー   日本造血免疫細胞療法学会・真菌感染症の予防と治療(第2版)部会  

    2020.07 - Now 

  • 作成グループ委員   日本臨床腫瘍学会・発熱性好中球減少症(FN)診療ガイドライン改訂版作成WG  

    2016.02 - 2017.08 

▼display all

Job Career (off-campus)

  • Dana-Farber Cancer Institute and Harvard Medical School   Department of Oncologic Pathology, Molecular Pathological Epidemiology Lab   research scholar

    2016.09 - 2017.11

Education

  • Osaka City University   Doctor's Course   Graduated/Completed

    - 2011

  • Osaka City University     Graduated/Completed

    - 2002

Papers

  • Autotaxin is a potential predictive marker for the development of veno-occlusive disease/sinusoidal obstruction syndrome after allogeneic hematopoietic cell transplantation. Reviewed

    Takemura K, Nakamae M, Okamura H, Sakatoku K, Ido K, Makuuchi Y, Kuno M, Takakuwa T, Hirose A, Nishimoto M, Nakashima Y, Koh H, Igarashi K, Kubota H, Hino M, Nakamae H

    Annals of hematology   2024.03( ISSN:0939-5555

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00277-024-05685-0

    PubMed

  • A comparison of long-term outcomes by donor type in the era of post-transplantation cyclophosphamide for aggressive adult T-cell leukemia/lymphoma. Reviewed

    Hirose A, Koh H, Nakamae M, Nakashima Y, Nishimoto M, Okamura H, Makuuchi Y, Kuno M, Takakuwa T, Ido K, Sakatoku K, Hino M, Nakamae H

    Bone marrow transplantation   2024.02( ISSN:0268-3369

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41409-024-02231-4

    PubMed

  • Pretransplant hepatomegaly is linked to relapse in patients with leukemia and myelodysplastic syndrome not in remission. Reviewed

    Okayama Y, Harada N, Makuuchi Y, Kuno M, Takakuwa T, Okamura H, Hirose A, Nakamae M, Nishimoto M, Nakashima Y, Koh H, Hino M, Nakamae H

    International journal of hematology   2024.01( ISSN:0925-5710

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s12185-023-03707-7

    PubMed

  • Comparison of long-term outcomes after first HLA-mismatched unrelated donor transplantation with single unrelated cord blood transplantation using reduced-intensity or reduced-toxicity conditioning. Reviewed

    Kuno M, Koh H, Ido K, Sakatoku K, Makuuchi Y, Takakuwa T, Hirose A, Okamura H, Nishimoto M, Nakashima Y, Nakamae M, Hino M, Nakamae H

    Transplant immunology   82   101988   2024.01( ISSN:0966-3274

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.trim.2024.101988

    PubMed

  • HLA-Haploidentical Peripheral Blood Stem Cell Transplantation with Post-Transplantation Cyclophosphamide versus HLA-Matched Unrelated Donor Transplantation for Myelodysplastic Syndrome. Reviewed

    Nakaya Y, Koh H, Konuma T, Shimomura Y, Ishiyama K, Itonaga H, Hino M, Doki N, Nishida T, Ohigashi H, Matsuoka KI, Kanda Y, Maruyama Y, Sawa M, Eto T, Hiramoto N, Fukuda T, Atsuta Y, Nakamae H

    Transplantation and cellular therapy   2023.10( ISSN:26666367

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.jtct.2023.10.021

    PubMed

  • Third HLA-haploidentical stem cell transplantation using post-transplant cyclophosphamide for relapsed acute leukemia. Reviewed

    Harada N, Okamura H, Makuuchi Y, Kuno M, Takakuwa T, Nakamae M, Nishimoto M, Nakashima Y, Koh H, Hino M, Nakamae H

    Bone marrow transplantation   2023.09( ISSN:0268-3369

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41409-023-02108-y

    PubMed

  • The safety of the combination therapy of recombinant factor VIIa and plasma-derived factor VIIa and factor X for refractory hemorrhage in acquired hemophilia A. Reviewed

    Okayama Y, Bingo M, Sakatoku K, Okamura H, Nanno S, Nishimoto M, Nakashima Y, Koh H, Hino M, Nakamae H

    Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis   34 ( 6 )   419 - 422   2023.09( ISSN:0957-5235

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.1097/MBC.0000000000001243

    PubMed

  • Sinusoidal obstruction syndrome associated with disseminated toxoplasmosis involving the liver after allogeneic hematopoietic stem cell transplantation: A case report. Reviewed

    Makuuchi Y, Tanaka S, Koh H, Niki M, Norose K, Nakaya Y, Ido K, Sakatoku K, Kuno M, Harada N, Takakuwa T, Hirose A, Okamura H, Nishimoto M, Nakashima Y, Nakamae M, Hikosaka K, Kakeya H, Ohsawa M, Hino M, Nakamae H

    Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy   2023.05( ISSN:1341-321X

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.jiac.2023.05.009

    PubMed

  • Effect of graft cell dose on second transplantation from a haploidentical donor with post-transplantation cyclophosphamide for relapsed/refractory acute leukemia. Reviewed

    Nakaya Y, Nakamae H, Harada N, Okamura H, Sakatoku K, Ido K, Makuuchi Y, Kuno M, Takakuwa T, Hirose A, Nakamae M, Nishimoto M, Nakashima Y, Koh H, Hino M

    Bone marrow transplantation   2023.04( ISSN:0268-3369

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41409-023-01986-6

    PubMed

  • Posttransplant cyclophosphamide contributes to the impairment of the graft-versus-leukemia effect and the amelioration of graft-versus-host disease with the suppression of alloreactive T cells in a murine stem cell transplant model. Reviewed

    Makuuchi Y, Nakashima Y, Nishimoto M, Koh H, Hino M, Nakamae H

    Experimental hematology   2023.04( ISSN:0301-472X

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.exphem.2023.04.003

    PubMed

  • Fulminant Metastatic Cellulitis Caused by Stenotrophomonas Maltophilia Infection and Subsequent Candida Parapsilosis Fungemia After Cord Blood Transplantation. Reviewed

    Takagi I, Harada N, Niki M, Yamada K, Makuuchi Y, Kuno M, Takakuwa T, Okamura H, Nishimoto M, Nakashima Y, Koh H, Kakeya H, Hino M, Nakamae H

    Transplantation proceedings   55 ( 3 )   706 - 710   2023.04( ISSN:0041-1345

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.transproceed.2023.02.028

    PubMed

  • Rhinovirus/enterovirus identification by electron microscopy in lower respiratory tract infection in a patient with relapsed myelodysplastic syndrome after allogeneic hematopoietic cell transplantation and donor lymphocyte infusion. Reviewed

    Harada N, Nakashima Y, Sakaida M, Mukai D, Makuuchi Y, Kuno M, Takakuwa T, Okamura H, Nishimoto M, Koh H, Ohsawa M, Hino M, Nakamae H

    Transplant immunology   77   101792   2023.04( ISSN:0966-3274

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.trim.2023.101792

    PubMed

  • The relationship of alcohol consumption and drinking pattern to the risk of glomerular hyperfiltration in middle-aged Japanese men: the Kansai Healthcare Study. Reviewed

    Shibata M, Sato KK, Koh H, Shibata I, Okamura K, Takeuchi Y, Oue K, Morimoto M, Hayashi T

    Journal of epidemiology   2023.03( ISSN:0917-5040

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.2188/jea.JE20220312

    PubMed

  • Salvage Human Leukocyte Antigen-Haploidentical Hematopoietic Cell Transplant With Posttransplant Cyclophosphamide for Graft Failure in a Patient With Chronic Active Epstein-Barr Virus Infection. Reviewed

    Nakaya Y, Koh H, Harada N, Okamura H, Misugi T, Suekane T, Tachibana D, Kimura H, Hino M, Nakamae H

    Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation   21 ( 2 )   184 - 188   2023.02( ISSN:1304-0855

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.6002/ect.2022.0322

    PubMed

  • Polatuzumab vedotin in previously untreated DLBCL: an Asia subpopulation analysis from the Phase 3 POLARIX trial. Reviewed International coauthorship

    Song Y, Tilly H, Rai S, Zhang H, Jin J, Goto H, Terui Y, Shin HJ, Kim WSS, Cao J, Feng J, Eom HS, Kim TM, Tsai XC, Gau JP, Koh H, Zhang L, Song Y, Yang Y, Li W, Huang H, Ando K, Sharman JP, Sehn LH, Bu L, Wang X, Jiang Y, Hirata J, Lee C, Zhu J, Izutsu K

    Blood   2023.01( ISSN:0006-4971

     More details

    Publishing type:Research paper (scientific journal)   International / domestic magazine:International journal  

    DOI: 10.1182/blood.2022017734

    PubMed

  • Two cases of eosinophilic gastrointestinal disorder due to newly appearing food allergies after cord blood transplantation. Reviewed

    Harada N, Makuuchi Y, Kuno M, Takakuwa T, Okamura H, Nishimoto M, Nakashima Y, Koh H, Sakaida M, Tanaka S, Kuwae Y, Higashimori A, Tanaka F, Ohsawa M, Fujiwara Y, Hino M, Nakamae H

    Transplant immunology   101781   2023.01( ISSN:0966-3274

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.trim.2022.101781

    PubMed

  • Recapitulated Late-Onset Inflammatory Toxicities and Progressive Dysautonomia with Persistence of Central Memory CD4+ Chimeric Antigen Receptor T Cells in a Case of Transformed Follicular Lymphoma: Case Report. Reviewed

    Nishimoto M, Takakuwa T, Kuno M, Makuuchi Y, Okamura H, Nakashima Y, Koh H, Namba H, Itoh Y, Hino M, Nakamae H

    Acta haematologica   146 ( 4 )   338 - 342   2023( ISSN:0001-5792

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.1159/000530743

    PubMed

  • Successful treatment of proven coronavirus disease 2019-associated pulmonary aspergillosis with liposomal amphotericin B in a patient with bronchiolitis obliterans syndrome after allogeneic hematopoietic stem cell transplantation. Reviewed

    Nakaya Y, Nakashima Y, Harada N, Yamada K, Makuuchi Y, Kuno M, Takakuwa T, Okamura H, Nanno S, Nishimoto M, Koh H, Nakagama Y, Kido Y, Kanno T, Suzuki T, Nakamae H, Kakeya H, Hino M

    Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy   2022.11( ISSN:1341-321X

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.jiac.2022.10.020

    PubMed

  • Intramural esophageal hematoma precipitated by acquired factor XI deficiency in a patient with relapsed T cell prolymphocytic leukemia after allogeneic hematopoietic cell transplantation. Reviewed

    Harada N, Makuuchi Y, Kuno M, Takakuwa T, Okamura H, Nishimoto M, Nakashima Y, Koh H, Bingo M, Higashimori A, Fujiwara Y, Hino M, Nakamae H

    Annals of hematology   101 ( 11 )   2567 - 2569   2022.11( ISSN:0939-5555

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00277-022-04970-0

    PubMed

  • Polatuzumab vedotin combined with rituximab-bendamustine immediately before stem cell mobilization in relapsed diffuse large B-cell lymphoma. Reviewed

    Takakuwa T, Okayama Y, Nakamae H, Kuno M, Makuuchi Y, Harada N, Okamura H, Nishimoto M, Nakashima Y, Koh H, Hino M

    Annals of hematology   101 ( 7 )   1609 - 1610   2022.07( ISSN:0939-5555

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00277-022-04803-0

    PubMed

  • Immunomodulatory and direct activities of ropeginterferon alfa-2b on cancer cells in mouse models of leukemia. Reviewed

    Sakatoku K, Nakashima Y, Nagasaki J, Nishimoto M, Hirose A, Nakamae M, Koh H, Hino M, Nakamae H

    Cancer science   113 ( 7 )   2246 - 2257   2022.07( ISSN:1347-9032

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/cas.15376

    PubMed

  • Phagocytosis of Mature Granulocytes by Bone Marrow Macrophages in an Elderly Man with Adult-Onset Primary Autoimmune Neutropenia. Reviewed

    Nishimoto M, Nakane T, Koh H, Nakashima Y, Yamamura R, Nakamae H, Hino M, Ohta K

    Hematology reports   14 ( 2 )   165 - 171   2022.05( ISSN:2038-8322

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.3390/hematolrep14020024

    PubMed

  • Predictive value of clinical examination parameters for cardiovascular adverse events during treatment of chronic myeloid leukemia with tyrosine kinase inhibitors. Reviewed

    Nakamae M, Nakamae H, Hashimoto M, Koh H, Nakashima Y, Hirose A, Hino M

    International journal of hematology   115 ( 3 )   329 - 335   2022.03( ISSN:0925-5710

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s12185-021-03259-8

    PubMed

  • Delayed immune-related neutropenia with hepatitis by pembrolizumab. Reviewed

    Nakako S, Nakashima Y, Okamura H, Tani Y, Ueda T, Makuuchi Y, Kuno M, Takakuwa T, Nishimoto M, Koh H, Nakamae H, Hino M

    Immunotherapy   14 ( 2 )   101 - 105   2022.02( ISSN:1750-743X

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.2217/imt-2021-0131

    PubMed

  • Effect of donor NKG2D polymorphism on relapse after haploidentical transplantation with post-transplant cyclophosphamide. Reviewed

    Ido K, Koh H, Hirose A, Seto T, Makuuchi Y, Kuno M, Takakuwa T, Okamura H, Nanno S, Nakamae M, Nishimoto M, Nakashima Y, Hino M, Nakamae H

    Transplantation and cellular therapy   28 ( 1 )   20.e1 - 20.e10   2022.01( ISSN:2666-6375

     More details

    Authorship:Corresponding author   Publishing type:Research paper (scientific journal)   International / domestic magazine:International journal  

    DOI: 10.1016/j.jtct.2021.09.019

    PubMed

  • A Prospective Study of an HLA-Haploidentical Peripheral Blood Stem Cell Transplantation Regimen Based on Modification of the Dose of Posttransplant Cyclophosphamide for Poor Prognosis or Refractory Hematological Malignancies Reviewed

    Nakamae H, Okamura H, Hirose A, Koh H, Nakashima Y, Nakamae M, Nishimoto M, Makuuchi Y, Kuno M, Harada N, Takakuwa T, Hino M.

    Cell Transplant   31   9636897221   2022.01

     More details

    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work   International / domestic magazine:International journal  

    DOI: 10.1177/09636897221112098

  • Impact of a WEB notifying system on the coordination process length in the Japan Marrow Donor Program Reviewed

    Hino Masayuki, Umemoto Yukari, Makuuchi Yosuke, Okamura Hiroshi, Koh Hideo, Hagiyama Keiko, Orihara Katsumi, Nakao Takafumi, Okada Masaya, Uoshima Nobuhiko, Itoh Mitsuru, Yakushijin Kimikazu, Nishikawa Akinori, Ishikawa Jun, Mizuno Ishikazu, Ishikawa Takayuki, Fukuda Takahiro

    Japanese Journal of Transplantation and Cellular Therapy   11 ( 2 )   114 - 121   2022

     More details

    Publishing type:Research paper (scientific journal)   International / domestic magazine:Domestic journal  

    <p> In cooperation with the Kinki branch office of the Japan Marrow Donor Program, we verified the problems in current coordination and constructed a WEB system to provide a notification of the harvest schedule at each hospital. After introducing this system, the median time between donor selection and collection and actual transplant were 70-78 days in 2013-2016 and 57-63 days in 2017-2020 without refusal. The collection rate in the first-choice week of patients increased 29-38% in 2013-2016, to 32% in 2017, and 63-73% in 2018-2020. Additionally, the role of the hematopoietic cell transplant coordinator was important for improving the efficiency of collection and reducing the workload of hematologists. This system helped improve the efficiency of harvesting. In contrast, there was disparity in the harvest experience of various hospitals. In the future, the development of teaching harvest techniques and skills to improve donor safety will be an important problem.</p>

    DOI: 10.7889/tct-21-020

    CiNii Article

  • Body Mass Index and the Risk of Persistent Proteinuria in Middle-Aged Men: The Kansai Healthcare Study. Reviewed

    Shibata I, Shibata M, Sato KK, Takeuchi Y, Okamura K, Koh H, Oue K, Morimoto M, Hayashi T

    American journal of nephrology   53 ( 2-3 )   191 - 198   2022( ISSN:0250-8095

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.1159/000521885

    PubMed

  • AL amyloidosis presenting with fluminant multiorgan failure accompanied by rapid progression from MGUS to multiple myeloma Reviewed

    TAZOE Kumiyo, TAKAKUWA Teruhito, MAKUUCHI Yosuke, KUNO Masatomo, HARADA Naonori, OKAMURA Hiroshi, NISHIMOTO Mitsutaka, KOH Hideo, NAKASHIMA Yasuhiro, NAKAMAE Hirohisa, HINO Masayuki

    Rinsho Ketsueki   63 ( 1 )   31 - 36   2022( ISSN:0485-1439

     More details

    Publishing type:Research paper (scientific journal)  

    <p>Monoclonal gammopathy of undermined significance (MGUS) is usually asymptomatic, and untreated follow-up is the standard treatment. However, MGUS progresses to multiple myeloma or related malignancy at a frequency of 1.5% per year. It is sometimes difficult to diagnose the progression of the disease via usual examinations. We herein report a case wherein rapid renal dysfunction led to a diagnosis of disease progression to multiple myeloma in a patient with MGUS that was asymptomatic for a long time. A 66-year-old woman developed rapid renal dysfunction requiring continuous hemodiafiltration 8 years after the diagnosis of IgA-κ type MGUS. A complete examination led to the diagnosis of IgA-κ type multiple myeloma. Chemotherapy was not effective, and she died due to sepsis on the 19th day of admission. A pathological autopsy revealed systemic amyloidosis and multiple abscesses positive for <i>Staphylococcus aureus</i>. An abnormal free light chain κ/λ ratio and M protein other than IgG are reportedly risk factors of disease progression of MGUS. In cases with these risk factors, it is important to always keep in mind the possibility of disease progression and to monitor the patient carefully for an early diagnosis.</p>

    DOI: 10.11406/rinketsu.63.31

    PubMed

    CiNii Article

  • Warm autoimmune hemolytic anemia and IgM-monoclonal gammopathy following BNT162b2 COVID-19 vaccine in a patient with splenic marginal zone lymphoma Reviewed

    SOGABE Nobuhiro, KUNO Masatomo, NAKAGAMA Yu, MAKUUCHI Yosuke, HARADA Naonori, TAKAKUWA Teruhito, OKAMURA Hiroshi, HIROSE Asao, NISHIMOTO Mitsutaka, NAKASHIMA Yasuhiro, KOH Hideo, NAKAMAE Mika, KIDO Yasutoshi, NAKAMAE Hirohisa, HINO Masayuki

    Rinsho Ketsueki   63 ( 10 )   1379 - 1385   2022( ISSN:0485-1439

     More details

    Publishing type:Research paper (scientific journal)  

    <p>There is currently no evidence that a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mRNA vaccine might be associated with the development of autoimmune hemolytic anemia or disease progression in patients with mature B-cell neoplasm. Our patient was a 71-year-old man with indolent mature B-cell neoplasm who had been monitored for many years without treatment. After receiving the second dose of the BNT162b2 mRNA COVID-19 vaccine, he developed severe warm autoimmune hemolytic anemia. Although steroid therapy improved his anemia, he continued to develop IgM-monoclonal gammopathy, renal insufficiency, and splenomegaly. He was diagnosed with splenic marginal zone lymphoma after undergoing splenectomy. The splenectomy improved the patient’s symptoms. We assessed his SARS-CoV-2 specific antibody response, but the patient’s serologic response to the vaccine was impaired. In patients with mature B-cell neoplasm, a non-specific immune response after vaccination might be associated with paraneoplastic syndromes.</p>

    DOI: 10.11406/rinketsu.63.1379

    PubMed

  • Increasing numbers of CD19+CD24(high)CD38(high) regulatory B cells and pre-germinal center B cells reflect activated autoimmunity and predict future treatment response in patients with untreated immune thrombocytopenia Reviewed

    Hayashi Tetsuya, Nakamae Hirohisa, Takeda Shinichi, Nakashima Yasuhiro, Koh Hideo, Nishimoto Mitsutaka, Okamura Hiroshi, Nanno Satoru, Makuuchi Yosuke, Kuno Masatomo, Nakamae Mika, Hirose Asao, Hino Masayuki

    INTERNATIONAL JOURNAL OF HEMATOLOGY   114 ( 5 )   580 - 590   2021.11( ISSN:0925-5710

     More details

    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

    DOI: 10.1007/s12185-021-03192-w

    PubMed

  • Isatuximab plus Pomalidomide and Dexamethasone in a Patient with Dialysis-Dependent Multiple Myeloma. Reviewed

    Takakuwa T, Ohta K, Sogabe N, Nishimoto M, Kuno M, Makuuchi Y, Okamura H, Nakashima Y, Koh H, Nakamae H, Hino M

    Chemotherapy   1 - 4   2021.10( ISSN:0009-3157

     More details

    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

    DOI: 10.1159/000519783

    PubMed

  • Tiny transformed diffuse large B cell lymphoma localized to the left conjunctiva Reviewed

    Harada Naonori, Tagami Mizuki, Koh Hideo, Ohsawa Masahiko, Hino Masayuki, Nakamae Hirohisa

    INTERNATIONAL JOURNAL OF HEMATOLOGY   114 ( 4 )   413 - 414   2021.10( ISSN:0925-5710

     More details

    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

    DOI: 10.1007/s12185-021-03208-5

    PubMed

  • A phase II study of post-transplant cyclophosphamide combined with tacrolimus for GVHD prophylaxis after HLA-matched related/unrelated allogeneic hematopoietic stem cell transplantation Reviewed

    Nakamae Hirohisa, Nakane Takahiko, Okamura Hiroshi, Koh Hideo, Nakashima Yasuhiro, Hirose Asao, Nakamae Mika, Nishimoto Mitsutaka, Kuno Masatomo, Makuuchi Yosuke, Harada Naonori, Takakuwa Teruhito, Hino Masayuki

    INTERNATIONAL JOURNAL OF HEMATOLOGY   2021.09( ISSN:0925-5710

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s12185-021-03228-1

    PubMed

  • Kinetics of IgG subclasses and their effects on the incidence of infection after allogeneic hematopoietic stem cell transplantation Reviewed

    Koh Shiro, Koh Hideo, Nanno Satoru, Okamura Hiroshi, Nakashima Yasuhiro, Nakamae Mika, Hirose Asao, Hino Masayuki, Nakamae Hirohisa

    TRANSPLANT IMMUNOLOGY   67   101413   2021.08( ISSN:0966-3274

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.trim.2021.101413

    PubMed

  • Early Elevation of Complement Factor Ba Is a Predictive Biomarker for Transplant-Associated Thrombotic Microangiopathy Reviewed

    Okamura Hiroshi, Nakamae Hirohisa, Shindo Takero, Ohtani Katsuki, Hidaka Yoshihiko, Ohtsuka Yasufumi, Makuuchi Yosuke, Kuno Masatomo, Takakuwa Teruhito, Harada Naonori, Nishimoto Mitsutaka, Nakashima Yasuhiro, Koh Hideo, Hirose Asao, Nakamae Mika, Wakamiya Nobutaka, Hino Masayuki, Inoue Norimitsu

    FRONTIERS IN IMMUNOLOGY   12   695037   2021.07( ISSN:1664-3224

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.3389/fimmu.2021.695037

    PubMed

  • Successful management of therapy-related chronic myelomonocytic leukemia with cytarabine, aclarubicin, and azacitidine following tegafur/gimeracil/oteracil Reviewed

    Nakako Soichiro, Takakuwa Teruhito, Ichimura Hirona, Okamura Hiroshi, Nanno Satoru, Nishimoto Mitsutaka, Nakashima Yasuhiro, Koh Hideo, Hino Masayuki, Nakamae Hirohisa

    CLINICAL CASE REPORTS   9 ( 6 )   e04298   2021.06( ISSN:2050-0904

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/ccr3.4298

    PubMed

  • Risk factor and long-term outcome analyses for acute limbic encephalitis and calcineurin inhibitor-induced encephalopathy in adults following allogeneic hematopoietic cell transplantation Reviewed

    Tanizawa N, Koh H, Okamura H, Yamamoto K, Makuuchi Y, Kuno M, Takakuwa T, Koh S, Nanno S, Nishimoto M, Hirose A, Nakamae M, Nakashima Y, Nakane T, Hino M, Nakamae H

    Transplant Cell Ther   27 ( 5 )   437.e1 - 437.e9   2021.05

     More details

    Authorship:Corresponding author   Publishing type:Research paper (scientific journal)   Kind of work:Joint Work   International / domestic magazine:International journal  

  • Acute fibrinous and organizing pneumonia following hemophagocytic syndrome in two adult patients with hematological malignancies. Reviewed

    Nanno S, Koh H, Okamura H, Nishimoto M, Nakashima Y, Ohsawa M, Hino M, Nakamae H

    Journal of clinical and experimental hematopathology : JCEH   2021.04( ISSN:1346-4280

     More details

    Authorship:Corresponding author   Publishing type:Research paper (scientific journal)  

    DOI: 10.3960/jslrt.20042

    PubMed

  • ABO Blood Group and Risk of Pancreatic Carcinogenesis in Intraductal Papillary Mucinous Neoplasms. Reviewed

    Hamada T, Oyama H, Nakai Y, Tada M, Koh H, Tateishi K, Arita J, Hakuta R, Ijichi H, Ishigaki K, Kawaguchi Y, Kogure H, Mizuno S, Morikawa T, Saito K, Saito T, Sato T, Takagi K, Takahara N, Takahashi R, Tanaka A, Tanaka M, Ushiku T, Hasagawa K, Koike K

    Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology   2021.03( ISSN:1055-9965

     More details

    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

    DOI: 10.1158/1055-9965.EPI-20-1581

    PubMed

  • Pretransplant plasma brain natriuretic peptide and N-terminal probrain natriuretic peptide are more useful prognostic markers of overall survival after allogeneic hematopoietic cell transplantation than echocardiography Reviewed

    Harada Naonori, Okamura Hiroshi, Nakane Takahiko, Koh Shiro, Nanno Satoru, Nishimoto Mitsutaka, Hirose Asao, Nakamae Mika, Nakashima Yasuhiro, Koh Hideo, Hino Masayuki, Nakamae Hirohisa

    BONE MARROW TRANSPLANTATION   2021.02( ISSN:0268-3369

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41409-021-01224-x

    PubMed

  • Diffuse large B-cell lymphoma with markedly improved chylothorax by lymphangiography Reviewed

    MORIGUCHI Makoto, YAMAMOTO Akira, NAKAMAE Hirohisa, HINO Masayuki, TAKAKUWA Teruhito, KAGEYAMA Ken, OKAMURA Hiroshi, NANNO Satoru, NISHIMOTO Mitsutaka, NAKASHIMA Yasuhiro, KOH Hideo, NAKANE Takahiko

    The Japanese Society of Hematology, Rinsho Ketsueki   62 ( 6 )   554 - 559   2021( ISSN:0485-1439

     More details

    Publishing type:Research paper (scientific journal)  

    <p>Chylothorax is a rare clinical sign in patients with diffuse large B-cell lymphoma (DLBCL), which is often challenging to manage and has a poor prognosis. We report the case of a 59-year-old woman who presented with right pleural effusion at the time of DLBCL diagnosis. Lymphadenopathy rapidly improved in response to chemotherapy. However, the pleural effusion progressed and was identified as chylothorax by thoracentesis. Because attempts to manage the condition with fasting and central venous nutrition were unsuccessful, we performed ultrasound-guided intranodal lipiodol lymphangiography from the inguinal lymph node. Although leak sites were not detected, the pleural effusion markedly improved on the day after the examination and resolved after 2 months. Lymphangiography is a minimally invasive examination with few complications. It contributes not only to the identification of leak sites but also to the improvement and resolution of chylothorax. Therefore, lymphangiography should be considered for refractory chylothorax that is unresponsive to chemotherapy or nutritional management.</p>

    DOI: 10.11406/rinketsu.62.554

    PubMed

    CiNii Article

  • Effect of Prophylactic Post-transplant Ponatinib Administration on Outcomes in Patients With Philadelphia Chromosome-positive Acute Lymphoblastic Leukemia Reviewed

    Nanno Satoru, Matsumoto Kana, Nakamae Mika, Okamura Hiroshi, Nishimoto Mitsutaka, Hirose Asao, Koh Hideo, Nakashima Yasuhiro, Nakane Takahiko, Morita Kunihiko, Hino Masayuki, Nakamae Hirohisa

    CLINICAL LYMPHOMA MYELOMA & LEUKEMIA   20 ( 12 )   813 - +   2020.12( ISSN:2152-2650

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.clml.2020.07.005

    PubMed

  • Recurrence of Acute Lymphoblastic Leukemia with Bone Marrow Necrosis: A Case Report and Review of the Literature on the MRI Features of Bone Marrow Necrosis. Reviewed

    Harada N, Nishimoto M, Ikemoto A, Okamura H, Koh S, Nanno S, Nakashima Y, Koh H, Nakane T, Kuwae Y, Ohsawa M, Hino M, Nakamae H

    一般社団法人 日本内科学会 Internal medicine (Tokyo, Japan)   2020.10( ISSN:0918-2918

     More details

    Publishing type:Research paper (scientific journal)  

    <p>Bone marrow necrosis (BMN) is a rare but important complication of hematological malignancies. We report the case of a 52-year-old male patient with a recurrence of acute lymphoblastic leukemia (ALL) accompanied by BMN. After re-induction therapy, bone marrow aspiration (BMA) and biopsy from the iliac bone showed necrotic cells and eosinophilic debris, respectively. Magnetic resonance imaging (MRI) showed heterogeneous signals in the bilateral iliac bone, possibly reflecting various stages of BMN. BMA from the sternum eventually revealed the recurrence of ALL after a few weeks. Comprehensive assessments, including MRI and repeated bone marrow tests, are required when evaluating the underlying hematological malignancies of patients with BMN. </p>

    DOI: 10.2169/internalmedicine.5815-20

    PubMed

    CiNii Article

  • Clinical usefulness of very high serum soluble interleukin-2 receptor levels for the detection of tuberculous peritonitis in a patient with chronic myelogenous leukemia Reviewed

    Moriguchi Makoto, Koh Hideo, Hayashi Tetsuya, Okamura Hiroshi, Nanno Satoru, Nakashima Yasuhiro, Nakane Takahiko, Imoto Waki, Yamada Koichi, Kakeya Hiroshi, Hino Masayuki, Nakamae Hirohisa

    エルゼビア・ジャパン(株) Journal of Infection and Chemotherapy   26 ( 10 )   1054 - 1057   2020.10( ISSN:1341-321X

     More details

    Authorship:Corresponding author   Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

  • Successful treatment with baloxavir marboxil of a patient with peramivir-resistant influenza A/H3N2 with a dual E119D/R292K substitution after allogeneic hematopoietic cell transplantation: a case report Reviewed

    Harada Naonori, Shibata Wataru, Koh Hideo, Takashita Emi, Fujisaki Seiichiro, Okamura Hiroshi, Nanno Satoru, Yamada Koichi, Nakamae Hirohisa, Hino Masayuki, Kakeya Hiroshi

    BMC INFECTIOUS DISEASES   20 ( 1 )   478   2020.07

     More details

    Authorship:Corresponding author   Publishing type:Research paper (scientific journal)   International / domestic magazine:International journal  

    DOI: 10.1186/s12879-020-05205-1

    PubMed

  • Interactive web application for plotting personalized prognosis prediction curves in allogeneic hematopoietic cell transplantation using machine learning. Reviewed

    Okamura H, Nakamae M, Koh S, Nanno S, Nakashima Y, Koh H, Nakane T, Hirose A, Hino M, Nakamae H

    Transplantation   2020.06( ISSN:0041-1337

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.1097/TP.0000000000003357

    PubMed

  • Donor KIR2DS1-Mediated Decreased Relapse and Improved Survival Depending on Remission Status at HLA-Haploidentical Transplantation with Post-Transplantation Cyclophosphamide. Reviewed

    Ido K, Koh H, Hirose A, Okamura H, Koh S, Nanno S, Nishimoto M, Nakamae M, Nakashima Y, Nakane T, Hino M, Nakamae H

    Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation   26 ( 4 )   723 - 733   2020.04( ISSN:1083-8791

     More details

    Authorship:Corresponding author   Publishing type:Research paper (scientific journal)   International / domestic magazine:International journal  

    DOI: 10.1016/j.bbmt.2019.12.765

    PubMed

  • 血清γ-グルタミルトランスフェラーゼ、毎日のアルコール摂取量、慢性腎不全のリスクの関係性 関西ヘルスケア研究(Serum Gamma-Glutamyltransferase, Daily Alcohol Consumption, and the Risk of Chronic Kidney Disease: The Kansai Healthcare Study) Reviewed

    Shibata Mikiko, Kogawa Sato Kyoko, Uehara Shinichiro, Koh Hideo, Oue Keiko, Kambe Hiroshi, Morimoto Michio, Hayashi Tomoshige

    日本疫学会 Journal of Epidemiology   30 ( 3-4 )   163 - 169   2020.04( ISSN:0917-5040

     More details

    Publishing type:Research paper (scientific journal)  

    <Highlight>●血清γ-GTPと慢性腎臓病発症との関連を検討した。●血清γ-GTP上昇は飲酒とは独立して持続蛋白尿発症リスクを増大させた。●血清γ-GTP値と飲酒を組み合わせて解析すると、非飲酒者でγ-GTP高値群の持続蛋白尿発症リスクが最も高かった。●血清γ-GTPと腎機能低下については関連を認めなかった。(著者抄録)

  • A noninvasive diagnostic approach using per-rectal portal scintigraphy for sinusoidal obstruction syndrome after allogeneic hematopoietic cell transplantation Reviewed

    Okamura Hiroshi, Koh Hideo, Takakuwa Teruhito, Ido Kentaro, Makuuchi Yosuke, Ine Shoji, Nanno Satoru, Nakashima Yasuhiro, Nakane Takahiko, Jogo Atsushi, Yamamoto Akira, Hamuro Masao, Kotani Kohei, Kawabe Joji, Higashiyama Shigeaki, Yoshida Atsushi, Shiomi Susumu, Ohsawa Masahiko, Hino Masayuki, Nakamae Hirohisa

    BONE MARROW TRANSPLANTATION   55 ( 2 )   470 - 472   2020.02( ISSN:0268-3369

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41409-019-0537-x

    PubMed

  • Clinical Characteristics of Rapidly Progressive Fatal Hemorrhagic Pneumonia Caused by <i>Stenotrophomonas maltophilia</i>

    Imoto Waki, Yamada Koichi, Yamairi Kazushi, Shibata Wataru, Namikawa Hiroki, Yukawa Satomi, Yoshii Naoko, Nakaie Kiyotaka, Hirose Asao, Koh Hideo, Watanabe Tetsuya, Asai Kazuhisa, Nakamae Hirohisa, Kaneko Yukihiro, Kawaguchi Tomoya, Hino Masayuki, Kakeya Hiroshi

    Internal Medicine   59 ( 2 )   193 - 198   2020.01( ISSN:09182918

     More details

    Publishing type:Research paper (scientific journal)  

    <p><b>Objective </b>Hemorrhagic pneumonia due to <i>Stenotrophomonas maltophilia</i> (SM) in severely immunocompromised patients has a very poor prognosis. However, the risk factors for hemorrhagic pneumonia are not clear. </p><p><b>Methods </b>This study assessed the predictive factors of hemorrhagic pneumonia caused by SM. The medical records of patients admitted to Osaka City University Hospital with SM bacteremia between January 2008 and December 2017 were retrospectively reviewed. </p><p><b>Patients </b>All patients who had positive blood cultures for SM were included in this study. They were categorized into two groups: the SM bacteremia with hemorrhagic pneumonia group and the SM bacteremia without hemorrhagic pneumonia group. The clinical background characteristics and treatments were compared between these groups. </p><p><b>Results </b>The 35 patients with SM bacteremia included 4 with hemorrhagic pneumonia and 31 without hemorrhagic pneumonia. Hematologic malignancy (p=0.03) and thrombocytopenia (p=0.04) as well as the prior use of quinolone within 30 days (p=0.04) were more frequent in the SM bacteremia patients with hemorrhagic pneumonia than in those without hemorrhagic pneumonia. The mortality of the SM bacteremia patients with hemorrhagic pneumonia was higher than that of those without hemorrhagic pneumonia group (p=0.02). </p><p><b>Conclusion </b>Patients with SM bacteremia who have hematologic malignancy, thrombocytopenia, and a history of using quinolone within the past 30 days should be treated with deliberation. </p>

    DOI: 10.2169/internalmedicine.3358-19

    PubMed

    CiNii Article

  • Safety profile of the concomitant use of foscarnet and aerosolized pentamidine in allogeneic hematopoietic stem cell transplantation recipients Reviewed

    Takahashi Masaya, Takahashi Katsuyuki, Inose Ryo, Sugimoto Takashi, Koh Hideo, Hino Masayuki, Nagayama Katsuya

    TRANSPLANT INFECTIOUS DISEASE   22 ( 1 )   e13239   2020.01( ISSN:1398-2273

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/tid.13239

    PubMed

  • Pulmonary infiltration of acute monoblastic leukemia diagnosed by transbronchial lung biopsy Reviewed

    HARADA Naonori, NAKAMAE Hirohisa, NAKANE Takahiko, OKAMURA Hiroshi, NANNO Satoru, NAKASHIMA Yasuhiro, KOH Hideo, TANAKA Sayaka, OHSAWA Masahiko, HINO Masayuki

    The Japanese Society of Hematology, Rinsho Ketsueki   61 ( 1 )   27 - 32   2020( ISSN:0485-1439

     More details

    Publishing type:Research paper (scientific journal)  

    <p>A 65-year-old woman was urgently admitted to our hospital for antibiotic-resistant fever, hypoxemia, and hyperleukocytosis and was diagnosed with acute monoblastic leukemia. Chest computed tomography revealed interlobular septal thickening, central ground-glass opacity, and a nodular shadow in the left lower lobe. Although several treatments for infectious disease and acute heart failure were administered, they were less effective. Transbronchial lung biopsy was performed on day 7 of hospitalization, and subsequently, pulmonary leukemic infiltration was confirmed. Based on the diagnosis, we decided to start intensive chemotherapy. Consequently, the abnormal lung shadow on computed tomography vanished, and complete hematological remission was achieved. Although acute myeloid leukemia is frequently associated with lung infiltration during onset, it is often difficult to distinguish it from other pulmonary complications. In clinical practice, intensive chemotherapy is often initiated based on the clinical evaluation without pathological confirmation of the lung disease. Our patient was accurately diagnosed based on the pulmonary leukemic infiltration observed pathologically and recovered well. Here we report our case along with a discussion of the relevant literature.</p>

    DOI: 10.11406/rinketsu.61.27

    PubMed

    CiNii Article

  • Erythrocytosis following allogeneic hematopoietic stem cell transplantation Reviewed

    KAWAHARA Hiroe, HIROSE Asao, HINO Masayuki, NAKAMAE Hirohisa, TAKAKUWA Teruhito, NAKAMAE Mika, KUBOTA Hiroshi, OKAMURA Hiroshi, NANNO Satoru, NAKASHIMA Yasuhiro, NAKANE Takahiko, KOH Hideo

    The Japanese Society of Hematology, Rinsho Ketsueki   61 ( 10 )   1492 - 1496   2020( ISSN:0485-1439

     More details

    Publishing type:Research paper (scientific journal)  

    <p>Post-transplant erythrocytosis (PTE) following allogeneic hematopoietic stem cell transplantation (alloHSCT) is rare, and the clinical characteristics of this condition remain unknown. In this study, we examined the clinical characteristics of three PTE cases among 321 patients who received allo HSCT from January 1992 to December 2011 at our institution. All three patients exhibited normal levels of white blood cell and platelet counts when their hemoglobin levels reached their peak. Two patients exhibited normal levels of erythropoietin. No thrombosis or hemorrhage was observed in any of the three patients without cytoreductive therapy or an antiplatelet agent. All three patients tested negative for JAK2V617F mutations. Two patients had high levels of IL-13, an upstream signal for the JAK/STAT pathway. JAK2 is known to significantly contribute to the pathology of polycythemia vera; however, this pathology may differ from that of PTE. We believe that it is necessary to construct a more appropriate management structure for PTE by analyzing more case data in the future.</p>

    DOI: 10.11406/rinketsu.61.1492

    PubMed

    CiNii Article

  • Acquired Gray Platelet Syndrome Associated with Primary Myelofibrosis Reviewed

    Ido Kentaro, Nakane Takahiko, Tanizawa Nao, Makuuchi Yosuke, Okamura Hiroshi, Koh Shiro, Nanno Satoru, Nishimoto Mitsutaka, Hirose Asao, Nakamae Mika, Nakashima Yasuhiro, Koh Hideo, Hino Masayuki, Nakamae Hirohisa

    一般社団法人 日本内科学会 INTERNAL MEDICINE   59 ( 21 )   2751 - 2756   2020( ISSN:0918-2918

     More details

    Publishing type:Research paper (scientific journal)  

    <p>A 53-year-old man presented with uncontrolled bleeding caused by acquired platelet dysfunction accompanied by calreticulin-mutated primary myelofibrosis. Based on the detection of abnormal platelets, including large gray platelets, under light microscopy and the loss of the second wave of aggregation observed by light transmission aggregometry, the patient was diagnosed with platelet dysfunction accompanied by myeloproliferative neoplasms (MPNs). In addition, the absence of platelet α-granules was confirmed by electron microscopy. Therefore, this condition may be termed "acquired gray platelet syndrome." Acquired platelet dysfunction must be ruled out when abnormal platelets are observed in patients with MPNs. </p>

    DOI: 10.2169/internalmedicine.4912-20

    PubMed

    CiNii Article

  • High-dose polyclonal intravenous immunoglobulin therapy for refractory viral infections including viremia after allogeneic hematopoietic cell transplantation Reviewed

    IDO Kentaro, HINO Masayuki, NAKAMAE Hirohisa, NAKANE Takahiko, OKAMURA Hiroshi, NANNO Satoru, NISHIMOTO Mitsutaka, HIROSE Asao, NAKAMAE Mika, NAKASHIMA Yasuhiro, KOH Hideo

    The Japanese Society of Hematology, Rinsho Ketsueki   61 ( 3 )   215 - 222   2020( ISSN:0485-1439

     More details

    Publishing type:Research paper (scientific journal)  

    <p>Refractory viremia/viral disease is a major life-threatening complication that may arise among patients undergoing allogeneic hematopoietic cell transplantation (allo-HCT). This study aimed to clarify the therapeutic effect of high-dose polyclonal intravenous immunoglobulin (IVIG) against viremia/viral diseases after allo-HCT. We conducted a pilot study to investigate the therapeutic effect of 400 mg/kg of IVIG given for 5 consecutive days against refractory viremia/viral disease after allo-HCT. Overall, 7 patients were drug-resistant and the other 7 had not previously received any drug for their viremia/viral disease. All patients completed the 5-day therapy regimen of IVIG. A complete response at Day 56 was observed for 8 of 14 patients (57.1%). Additionally, 10 of 14 patients (71.4%) were alive at Day 56, although only one death occurred due to the viremia/viral disease. Remarkably, all 3 cases who developed exogenous viremia/viral diseases including respiratory syncytial virus pneumonia/bronchitis and human parvovirus B19 viremia achieved a complete response, suggesting that high-dose polyclonal IVIG may be more effective against exogenous viruses rather than endogenous ones. Congestive heart failure was observed in 1 patient. High-dose polyclonal IVIG could be an effective and feasible therapy for refractory viremia/viral disease after allo-HCT.</p>

    DOI: 10.11406/rinketsu.61.215

    PubMed

    CiNii Article

  • Pretransplant serum beta-2 microglobulin level is a potential novel prognostic marker of overall survival after allogeneic hematopoietic cell transplantation - a retrospective observational study Reviewed

    Harada Naonori, Nakane Takahiko, Nakamae Mika, Hashimoto Yoshinori, Okamura Hiroshi, Nanno Satoru, Nishimoto Mitsutaka, Hirose Asao, Nakashima Yasuhiro, Koh Hideo, Hino Masayuki, Nakamae Hirohisa

    TRANSPLANT INTERNATIONAL   2019.12( ISSN:0934-0874

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/tri.13564

    PubMed

  • Mosquito allergy: a novel strong prognostic symptom of outcome after allogeneic hematopoietic transplantation. Reviewed

    Koh S, Nakamae H, Nanno S, Nakane T, Nakashima Y, Koh H, Nakamae M, Hirose A, Hino M

    Bone marrow transplantation   2019.12( ISSN:0268-3369

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41409-019-0759-y

    PubMed

  • A prospective observational study of immune reconstitution following transplantation with post-transplant reduced-dose cyclophosphamide from HLA-haploidentical donors Reviewed

    Nakamae Hirohisa, Fujii Kazuki, Nanno Satoru, Okamura Hiroshi, Nakane Takahiko, Koh Hideo, Nakashima Yasuhiro, Nakamae Mika, Hirose Asao, Teshima Takanori, Hino Masayuki

    TRANSPLANT INTERNATIONAL   32 ( 12 )   1322 - 1332   2019.12( ISSN:0934-0874

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/tri.13494

    PubMed

  • Phase I study of graft-versus-host disease prophylaxis including bortezomib for allogeneic hematopoietic cell transplantation from unrelated donors with one or two HLA loci mismatches in Japanese patients. Reviewed

    Nakane T, Okamura H, Tagaito Y, Koh S, Yoshimura T, Makuuchi Y, Nanno S, Nakamae M, Hirose A, Nakashima Y, Koh H, Hino M, Nakamae H

    International journal of hematology   110 ( 6 )   736 - 742   2019.12( ISSN:0925-5710

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s12185-019-02743-6

    PubMed

  • Clinical Impacts of Using Serum IL-6 Level as an Indicator of Cytokine Release Syndrome after HLA-Haploidentical Transplantation with Post-Transplantation Cyclophosphamide Reviewed

    Nishimoto Mitsutaka, Hirose Asao, Koh Hideo, Nakamae Mika, Nanno Satoru, Okamura Hiroshi, Nakane Takahiko, Nakashima Yasuhiro, Hino Masayuki, Nakamae Hirohisa

    BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION   25 ( 10 )   2061 - 2069   2019.10( ISSN:1083-8791

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.bbmt.2019.06.003

    PubMed

  • Prognostic association of PTGS2 (COX-2) over-expression according to BRAF mutation status in colorectal cancer: Results from two prospective cohorts and CALGB 89803 (Alliance) trial. Reviewed International coauthorship

    Kosumi K, Hamada T, Zhang S, Liu L, da Silva A, Koh H, Twombly TS, Mima K, Morikawa T, Song M, Nowak JA, Nishihara R, Saltz LB, Niedzwiecki D, Ou FS, Zemla T, Mayer RJ, Baba H, Ng K, Giannakis M, Zhang X, Wu K, Giovannucci EL, Chan AT, Fuchs CS, Meyerhardt JA, Ogino S

    European journal of cancer (Oxford, England : 1990)   111   82 - 93   2019.04( ISSN:0959-8049

     More details

    Publishing type:Research paper (scientific journal)   International / domestic magazine:International journal  

    DOI: 10.1016/j.ejca.2019.01.022

    PubMed

  • Serum gamma-glutamyltransferase, daily alcohol consumption, and the risk of chronic kidney disease: the Kansai Healthcare Study. Reviewed

    Shibata M, Sato KK, Uehara S, Koh H, Oue K, Kambe H, Morimoto M, Hayashi T

    Journal of epidemiology   2019.03( ISSN:0917-5040

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.2188/jea.JE20180240

    PubMed

  • Short-Term Fasting Induces Cell Cycle Arrest in Immature Hematopoietic Cells and Increases the Number of Naïve T Cells in the Bone Marrow of Mice. Reviewed

    Takakuwa T, Nakashima Y, Koh H, Nakane T, Nakamae H, Hino M

    Acta haematologica   141 ( 3 )   189 - 198   2019.03( ISSN:0001-5792

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.1159/000496096

    PubMed

  • The Proportional Relationship between Pre-transplant WT1 mRNA Levels and Risk of Mortality after Allogeneic Hematopoietic Cell Transplantation in Acute Myeloid Leukemia Not in Remission. Reviewed

    Ido K, Nakamae M, Koh H, Okamura H, Nanno S, Nishimoto M, Takeoka Y, Hirose A, Nakashima Y, Hashimoto Y, Nakane T, Hino M, Nakamae H

    Transplantation   2019.02( ISSN:0041-1337

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.1097/TP.0000000000002662

    PubMed

  • Habitual Alcohol Intake Modifies Relationship of Uric Acid to Incident Chronic Kidney Disease Reviewed

    Okada Yuki, Uehara Shinichiro, Shibata Mikiko, Koh Hideo, Oue Keiko, Kambe Hiroshi, Morimoto Michio, Sato Kyoko Kogawa, Hayashi Tomoshige

    AMERICAN JOURNAL OF NEPHROLOGY   50 ( 1 )   55 - 62   2019( ISSN:0250-8095

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.1159/000500707

    PubMed

  • Refractory ascites caused by lymphatic flow disorder after stem cell transplantation for acute myeloid leukemia Reviewed

    TAKAKUWA Teruhito, HINO Masayuki, NAKAMAE Hirohisa, OKUNO Takahiro, NISHIMOTO Mitsutaka, NANNO Satoru, TAKEOKA Yasunobu, NAKASHIMA Yasuhiro, KOH Hideo, NAKANE Takahiko, WANIBUCHI Hideki

    The Japanese Society of Hematology, Rinsho Ketsueki   60 ( 1 )   12 - 16   2019( ISSN:0485-1439

     More details

    Publishing type:Research paper (scientific journal)  

    <p>In allogeneic hematopoietic stem cell transplantation (HSCT), ascites may develop owing to several causes, including sinusoidal obstruction syndrome, infections, malignancies, and malnutrition. However, it is often difficult to determine its precise cause. Here, a 59-year-old male developed chylous ascites three months post allogeneic bone marrow transplantation for relapsed acute myeloid leukemia. None of the attempted treatments resulted in improvement. Lymphangioscintigraphy revealed a lymphatic flow disorder at the level of the cisterna chyli. Autopsy revealed no leukemic cell infiltration or graft-versus-host disease of the liver or pancreas. The pancreatic specimen revealed parenchymal fibrosis and infiltration of plasma cells, suggesting chronic inflammation in addition to pathological changes caused by acute pancreatitis. These findings indicate that acute or chronic pancreatitis caused a lymphatic flow disorder that developed into refractory ascites. Although we could not diagnose pancreatitis while the patient was alive, it is important to recognize that asymptomatic pancreatitis can develop after HSCT. Furthermore, one should attempt to make an accurate diagnosis as early as possible.</p>

    DOI: 10.11406/rinketsu.60.12

    PubMed

    CiNii Article

  • Physical Activity and Colorectal Cancer Prognosis According to Tumor-Infiltrating T Cells Reviewed International coauthorship

    Koh Hideo, Hamada Tsuyoshi, Song Mingyang, Liu Li, Cao Yin, Nowak Jonathan A., da Silva Annacarolina, Twombly Tyler, Morikawa Teppei, Kim Sun A., Masugi Yohei, Kosumi Keisuke, Shi Yan, Gu Mancang, Li Wanwan, Du Chunxia, Chen Yang, Li Wenbin, Liu Hongli, Li Chenxi, Wu Kana, Nosho Katsuhiko, Inamura Kentaro, Hanyuda Akiko, Zhang Xuehong, Giannakis Marios, Chan Andrew T., Fuchs Charles S., Nishihara Reiko, Meyerhardt Jeffrey A., Ogino Shuji

    JNCI CANCER SPECTRUM   2 ( 4 )   pky058   2018.10

     More details

    Authorship:Lead author   Publishing type:Research paper (scientific journal)   International / domestic magazine:International journal  

    DOI: 10.1093/jncics/pky058

    PubMed

  • Validation of previous prognostic models for thrombosis and exploration of modified models in patients with essential thrombocythemia Reviewed

    Hashimoto Yoshinori, Nakamae Hirohisa, Tanaka Takayuki, Omura Hiromi, Horiuchi Mirei, Yoshimura Takuro, Takakuwa Teruhito, Mugitani Atsuko, Hirose Asao, Nakamae Mika, Koh Hideo, Hino Masayuki

    EUROPEAN JOURNAL OF HAEMATOLOGY   101 ( 4 )   508 - 513   2018.10( ISSN:0902-4441

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/ejh.13136

    PubMed

  • Diets That Promote Colon Inflammation Associate With Risk of Colorectal Carcinomas That Contain Fusobacterium nucleatum. Reviewed International coauthorship

    Liu L, Tabung FK, Zhang X, Nowak JA, Qian ZR, Hamada T, Nevo D, Bullman S, Mima K, Kosumi K, da Silva A, Song M, Cao Y, Twombly TS, Shi Y, Liu H, Gu M, Koh H, Li W, Du C, Chen Y, Li C, Li W, Mehta RS, Wu K, Wang M, Kostic AD, Giannakis M, Garrett WS, Hutthenhower C, Chan AT, Fuchs CS, Nishihara R, Ogino S, Giovannucci EL

    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association   16 ( 10 )   1622 - 1631.e3   2018.10( ISSN:1542-3565

     More details

    Publishing type:Research paper (scientific journal)   International / domestic magazine:International journal  

    DOI: 10.1016/j.cgh.2018.04.030

    PubMed

  • The Amount of Bifidobacterium Genus in Colorectal Carcinoma Tissue in Relation to Tumor Characteristics and Clinical Outcome. Reviewed International coauthorship

    Kosumi K, Hamada T, Koh H, Borowsky J, Bullman S, Twombly TS, Nevo D, Masugi Y, Liu L, da Silva A, Chen Y, Du C, Gu M, Li C, Li W, Liu H, Shi Y, Mima K, Song M, Nosho K, Nowak JA, Nishihara R, Baba H, Zhang X, Wu K, Wang M, Huttenhower C, Garrett WS, Meyerson ML, Lennerz JK, Giannakis M, Chan AT, Meyerhardt JA, Fuchs CS, Ogino S

    The American journal of pathology   2018.09( ISSN:0002-9440

     More details

    Authorship:Lead author   Publishing type:Research paper (scientific journal)   International / domestic magazine:International journal  

    DOI: 10.1016/j.ajpath.2018.08.015

    PubMed

  • <i>Fusobacterium nucleatum</i> in Colorectal Cancer Relates to Immune Response Differentially by Tumor Microsatellite Instability Status. Reviewed International coauthorship

    Hamada T, Zhang X, Mima K, Bullman S, Sukawa Y, Nowak JA, Kosumi K, Masugi Y, Twombly TS, Cao Y, Song M, Liu L, da Silva A, Shi Y, Gu M, Li W, Koh H, Nosho K, Inamura K, Keum N, Wu K, Meyerhardt JA, Kostic AD, Huttenhower C, Garrett WS, Meyerson M, Giovannucci EL, Chan AT, Fuchs CS, Nishihara R, Giannakis M, Ogino S

    Cancer immunology research   2018.09( ISSN:2326-6066

     More details

    Publishing type:Research paper (scientific journal)   International / domestic magazine:International journal  

    DOI: 10.1158/2326-6066.CIR-18-0174

    PubMed

  • metabolically healthy obesityと蛋白尿との関連 関西ヘルスケア研究(The Association Between Metabolically Healthy Obesity and the Risk of Proteinuria: The Kansai Healthcare Study) Reviewed

    Uehara Shinichiro, Kogawa Sato Kyoko, Koh Hideo, Shibata Mikiko, Kinuhata Shigeki, Yamada Akiko, Oue Keiko, Kambe Hiroshi, Morimoto Michio, Hayashi Tomoshige

    日本疫学会 Journal of Epidemiology   28 ( 7-8 )   361 - 366   2018.08( ISSN:0917-5040

     More details

    Publishing type:Research paper (scientific journal)  

    <Highlight>・メタボリックシンドロームの肥満以外の因子の有無により区別した「代謝的に健康、代謝的に不健康」と肥満の有無とを組み合わせ、蛋白尿発症との関係を調べた。・代謝的に健康な肥満者は蛋白尿発症リスクの上昇を認めなかった。・肥満の有無にかかわらず代謝的に不健康な者は蛋白尿発症リスクの上昇を認めた。(著者抄録)

  • 同種造血幹細胞移植後の類洞閉塞症候群予防を目的とした抗凝固薬とウルソデオキシコール酸の併用投与(Prophylactic Combined Use of Anticoagulant Agent and Ursodeoxycholic Acid for Sinusoidal Obstruction Syndrome after Allogeneic Myeloablative Hematopoietic Stem Cell Transplantation) Reviewed

    Okamura Hiroshi, Koh Hideo, Nishimoto Mitsutaka, Nakane Takahiko, Nakashima Yasuhiro, Nakamae Mika, Hirose Asao, Hino Masayuki, Nakamae Hirohisa

    大阪市医学会 Osaka City Medical Journal   64 ( 1 )   43 - 54   2018.06( ISSN:0030-6096

     More details

    Publishing type:Research paper (scientific journal)  

    当施設で骨髄破壊的前処置による同種造血幹細胞移植(HSCT)を受けた患者において、類洞閉塞症候群(SOS)の予防目的で行った凝固薬とウルソデオキシコール酸(UDCA)の併用投与の有効性を後ろ向きに評価した。2000年6月〜2014年5月にHSCT後のSOS予防のためUDCAとダルテパリンまたはダナパロイドのいずれかが併用投与された患者(I群)59例とUDCA単剤を投与された患者(II群)193例を対象とした。Seattle基準、Baltimore基準によるそれぞれのSOS発症率、および移植後30日、100日以内の出血イベント発症率を検討した。I群の59例中9例(15.3%)とII群の193例中28例(14.5%)がSOSを発症した。SOS発症率に関して両群間に有意差は認めなかった。移植後30日または100日以内の出血イベントの発症率においても、両群間で有意差を認めなかった。以上から、HSCT後のSOS予防にUDCAを使用する場合、抗凝固薬を併用投与することの意義は乏しいと考えられた。

  • Promising therapeutic option for cutaneous plasmacytosis: 308-nm excimer lamp. Reviewed

    Omura R, Sowa-Osako J, Fukai K, Kusutani N, Takeoka Y, Koh H, Ohsawa M, Iwatsuki K, Tsuruta D, Hamada T

    The Journal of dermatology   2018.02( ISSN:0385-2407

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/1346-8138.14262

    PubMed

  • Successful treatment with rituximab in acute disseminated encephalomyelitis with whole spinal cord involvement following HLA haploidentical transplantation Reviewed

    MAKUUCHI Yosuke, NAKAMAE Hirohisa, NISHIMOTO Mitsutaka, YAMAMOTO Keiichi, TAKAHASHI Toshiyuki, KUNO Masatomo, NAKASHIMA Yasuhiro, KOH Hideo, NAKANE Takahiko, HINO Masayuki

    The Japanese Society of Hematology, Rinsho Ketsueki   59 ( 12 )   2588 - 2593   2018( ISSN:0485-1439

     More details

    Publishing type:Research paper (scientific journal)  

    <p>Chronic graft versus host disease (cGVHD) of the central nervous system is a rare condition that could occur after allogeneic hematopoietic stem cell transplantation (SCT) but has been poorly documented. Here, we report a patient diagnosed with recurrent acute disseminated encephalomyelitis (ADEM) with longitudinal extensive transverse myelitis (LETM) as cGVHD after HLA haploidentical peripheral blood SCT using posttransplantation cyclophosphamide for mixed-phenotype acute leukemia. We observed clinical and radiological improvement after the rituximab treatment of the condition that had been refractory to steroids. To the best of our knowledge, no report of cGVHD presented recurrent ADEM with LETM after allogeneic SCT and successfully treated with rituximab. Hence, ADEM should be included in the differential diagnosis of neurological symptoms in posttransplant patients with cGVHD.</p>

    DOI: 10.11406/rinketsu.59.2588

    PubMed

    CiNii Article

  • The Association Between Metabolically Healthy Obesity and the Risk of Proteinuria: The Kansai Healthcare Study Reviewed

    Uchara Shinichiro, Sato Kyoko Kogawa, Koh Hideo, Shibata Mikiko, Kinuhata Shigeki, Yamada Akiko, Oue Keiko, Kambe Hiroshi, Morimoto Michio, Hayashi Tomoshige

    JOURNAL OF EPIDEMIOLOGY   28 ( 8 )   361 - 366   2018( ISSN:0917-5040

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.2188/jea.JE20170082

  • TIME (Tumor Immunity in the MicroEnvironment) classification based on tumor <i>CD274</i> (PD-L1) expression status and tumor-infiltrating lymphocytes in colorectal carcinomas. Reviewed International coauthorship

    Hamada T, Soong TR, Masugi Y, Kosumi K, Nowak JA, da Silva A, Mu XJ, Twombly TS, Koh H, Yang J, Song M, Liu L, Gu M, Shi Y, Nosho K, Morikawa T, Inamura K, Shukla SA, Wu CJ, Garraway LA, Zhang X, Wu K, Meyerhardt JA, Chan AT, Glickman JN, Rodig SJ, Freeman GJ, Fuchs CS, Nishihara R, Giannakis M, Ogino S

    Oncoimmunology   7 ( 7 )   e1442999   2018( ISSN:2162-4011

     More details

    Publishing type:Research paper (scientific journal)   International / domestic magazine:International journal  

    DOI: 10.1080/2162402X.2018.1442999

    PubMed

  • Diagnostic value of serum ferritin and cytokine profiles of hemophagocytic syndrome following allogeneic hematopoietic cell transplantation: methodological issues Reviewed

    Koh Hideo, Nanno Satoru, Hino Masayuki, Nakamae Hirohisa

    LEUKEMIA & LYMPHOMA   59 ( 3 )   772 - 773   2018( ISSN:1042-8194

     More details

    Authorship:Lead author   Publishing type:Research paper (scientific journal)   International / domestic magazine:International journal  

    DOI: 10.1080/10428194.2017.1361033

    PubMed

  • Outcome of Second Transplantation Using Umbilical Cord Blood for Graft Failure after Allogeneic Hematopoietic Stem Cell Transplantation for Aplastic Anemia Reviewed

    Onishi Yasushi, Mori Takehiko, Kako Shinichi, Koh Hideo, Uchida Naoyuki, Kondo Tadakazu, Kobayashi Takeshi, Yabe Hiromasa, Miyamoto Toshihiro, Kato Koji, Suzuki Ritsuro, Nakao Shinji, Yamazaki Hirohito

    BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION   23 ( 12 )   2137 - 2142   2017.12( ISSN:1083-8791

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.bbmt.2017.08.020

    PubMed

  • 日本人男性における血圧コンポーネントと蛋白尿リスク 関西ヘルスケア研究(Blood pressure components and the risk for proteinuria in Japanese men: The Kansai Healthcare Study) Reviewed

    Shibata Mikiko, Kogawa Sato Kyoko, Uehara Shinichiro, Koh Hideo, Kinuhata Shigeki, Oue Keiko, Kambe Hiroshi, Morimoto Michio, Hayashi Tomoshige

    日本疫学会 Journal of Epidemiology   27 ( 11-12 )   505 - 510   2017.12( ISSN:0917-5040

     More details

    Publishing type:Research paper (scientific journal)  

    血圧コンポーネントである収縮期血圧(SBP)、拡張期血圧(DBP)、脈圧、平均動脈圧(MAP)のうち、蛋白尿発症の最も有用な予測因子を、健康な日本人中年男性を対象とする前向きコホート研究により検討した。2000年4月〜2001年3月の登録時に糖尿病および蛋白尿がなく、推算糸球体濾過量≧60mL/分/1.73m2で、降圧薬未服用の40〜55歳の日本人男性9341名(登録時平均年齢48.2±4.2歳)を解析対象とした。まず、交絡因子から成るベースラインモデルに各血圧コンポーネントを個別に追加した。次に、各血圧コンポーネント追加によって持続性蛋白尿発症の予測能がそれぞれどの程度向上するのかを赤池情報量規準(AIC)により比較した。その結果、84587人・年の観察期間中に151名で持続性蛋白尿発症が確認された。いずれの血圧コンポーネントも持続性蛋白尿発症の有意な予測因子であった。第1四分位に対する第4四分位のハザード比は、SBPでは3.11(95%信頼区間[CI] 1.79-5.39)、脈圧は1.87(95%CI 1.18-2.94)、MAPは2.21(95%CI 1.33-3.69)と有意であった。DBPと持続性蛋白尿発症の関係はU字カーブであり、DBP第2四分位に対する第4四分位のハザード比は2.69(95%CI 1.65-4.38)と有意であった。ΔAICは、SBP追加モデルとDBP追加モデルにおいて最大であった。以上から、日本人中年男性において、SBPとDBPは持続性蛋白尿発症の最も有用な予測因子であると考えられた。

  • Autonomic Nervous System Pretransplant Malfunction Is a Powerful Predictor of Survival After Allogeneic Hematopoietic Cell Transplantation Reviewed

    Nakane Takahiko, Nakamae Mika, Koh Hideo, Nishimoto Mitsutaka, Nakashima Yasuhiro, Hirose Asao, Hino Masayuki, Nakamae Hirohisa

    TRANSPLANTATION   101 ( 11 )   2801 - 2809   2017.11( ISSN:0041-1337

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.1097/TP.0000000000001813

    PubMed

  • Blood pressure components and the risk for proteinuria in Japanese men: The Kansai Healthcare Study Reviewed

    Shibata Mikiko, Sato Kyoko Kogawa, Uehara Shinichiro, Koh Hideo, Kinuhata Shigeki, Oue Keiko, Kambe Hiroshi, Morimoto Michio, Hayashi Tomoshige

    日本疫学会 JOURNAL OF EPIDEMIOLOGY   27 ( 11 )   505 - 510   2017.11( ISSN:0917-5040

     More details

    Publishing type:Research paper (scientific journal)  

    <p><i>Background:</i> We examined prospectively which of the four blood pressure (BP) components (systolic BP [SBP], diastolic BP [DBP], pulse pressure [PP], and mean arterial pressure [MAP]) was best in predicting the risk of proteinuria.</p><p><i>Methods:</i> This prospective study included 9341 non-diabetic Japanese middle-aged men who had no proteinuria and an estimated glomerular filtration rate ≥60 mL/min/1.73 m<sup>2</sup> and were not taking antihypertensive medications at entry. Persistent proteinuria was defined if proteinuria was detected two or more times consecutively and persistently at the annual examination until the end of follow-up. We calculated the difference in values of Akaike's information criterion (ΔAIC) in comparison of the BP components-added model to the model without them in a Cox proportional hazards model.</p><p><i>Results:</i> During the 84,587 person-years follow-up period, we confirmed 151 cases of persistent proteinuria. In multiple-adjusted models that included a single BP component, the hazard ratios for persistent proteinuria for the highest quartile of SBP, PP, and MAP were 3.11 (95% confidence interval [CI], 1.79–5.39), 1.87 (95% CI, 1.18–2.94), and 2.21 (95% CI, 1.33–3.69) compared with the lowest quartile of SBP, PP, and MAP, respectively. The hazard ratio for the highest quartile of DBP was 2.69 (95% CI, 1.65–4.38) compared with the second quartile of DBP. Of all models that included a single BP component, those that included SBP alone or DBP alone had the highest values of ΔAIC (14.0 and 13.1, respectively) in predicting the risk of persistent proteinuria.</p><p><i>Conclusions:</i> Of all BP components, SBP and DBP were best in predicting the risk of persistent proteinuria in middle-aged Japanese men.</p>

    DOI: 10.1016/j.je.2016.10.010

    PubMed

    CiNii Article

  • Aspirin exerts high anti-cancer activity in <i>PIK3CA</i>-mutant colon cancer cells. Reviewed International coauthorship

    Gu M, Nishihara R, Chen Y, Li W, Shi Y, Masugi Y, Hamada T, Kosumi K, Liu L, da Silva A, Nowak JA, Twombly T, Du C, Koh H, Li W, Meyerhardt JA, Wolpin BM, Giannakis M, Aguirre AJ, Bass AJ, Drew DA, Chan AT, Fuchs CS, Qian ZR, Ogino S

    Oncotarget   8 ( 50 )   87379 - 87389   2017.10

     More details

    Publishing type:Research paper (scientific journal)   International / domestic magazine:International journal  

    DOI: 10.18632/oncotarget.20972

    PubMed

  • Drug interactions and safety profiles with concomitant use of caspofungin and calcineurin inhibitors in allogeneic haematopoietic cell transplantation Reviewed

    Nishimoto Mitsutaka, Koh Hideo, Tokuwame Atsushi, Makuuchi Yosuke, Kuno Masatomo, Takakuwa Teruhito, Okamura Hiroshi, Koh Shiro, Yoshimura Takuro, Nanno Satoru, Nakamae Mika, Hirose Asao, Nakashima Yasuhiro, Nakane Takahiko, Hino Masayuki, Nakamae Hirohisa

    BRITISH JOURNAL OF CLINICAL PHARMACOLOGY   83 ( 9 )   2000 - 2007   2017.09( ISSN:0306-5251

     More details

    Authorship:Corresponding author   Publishing type:Research paper (scientific journal)   International / domestic magazine:International journal  

    DOI: 10.1111/bcp.13303

    PubMed

  • 高用量メチルプレドニゾロン静注に応答した抗好中球抗体陽性無顆粒球症の高齢女性(An Elderly Woman with Anti-neutrophil Antibody-positive Agranulocytosis Who Responded to High-dose Intravenous Methylprednisolone) Reviewed

    Koh Shiro, Koh Hideo, Kubo Yuki, Kuroda Maiko, Nishimoto Mitsutaka, Yoshimura Takuro, Nakashima Yasuhiro, Nakane Takahiko, Nakamae Hirohisa, Ohsawa Masahiko, Hino Masayuki

    (一社)日本内科学会 Internal Medicine   56 ( 16 )   2199 - 2203   2017.08( ISSN:0918-2918

     More details

    Publishing type:Research paper (scientific journal)  

    症例は69歳女性で、2ヵ月前に原因不明の皮疹が出現し、その後、高熱、咽喉痛、全身疲労がみられた。今回、進行性白血球減少症と持続性発熱のため入院となった。数年間にわたり降圧薬、抗脂質異常薬、血栓予防目的でアスピリンを服用しており、1年前からは非ウイルス性肝炎に対してウルソデオキシコール酸を処方していた。所見から薬剤誘導性無顆粒球症と仮診断し、全ての処方薬を中止した。4日目にG-CSF投与とラミナエアフロー隔離を行った。広域抗生物質投与により高熱と咽頭痛は改善したが、好中球数は回復しなかった。その後、重度肺炎を発症し、11日目のCTで前縦隔腫瘍が明らかになった。G-CSF投与を継続した上で、20日目から高用量メチルプレドニゾロン静注療法(1g/日を3日間)を開始し、その後プレドニゾロン(1mg/kg)を投与した。40日目には好中球数が次第に正常範囲に改善したが、アスペルギルス肺炎と脳出血により46日目に死亡した。

  • 慢性骨髄性白血病患者におけるダサチニブ治療中の免疫プロファイルの変化 前向き観察研究(Immunoprofile Changes during Dasatinib Treatment in Patients with Chronic Myeloid Leukemia: A Prospective Observational Study) Reviewed

    Kuno Masatomo, Nakane Takahiko, Katayama Takako, Koh Hideo, Nakashima Yasuhiro, Nishimoto Mitsutaka, Nakamae Mika, Hirose Asao, Hino Masayuki, Nakamae Hirohisa

    大阪市医学会 Osaka City Medical Journal   63 ( 1 )   43 - 55   2017.06( ISSN:0030-6096

     More details

    Publishing type:Research paper (scientific journal)  

    ダサチニブ、イマチニブ、ニロチニブによる治療を行った慢性期の慢性骨髄性白血病(CML)患者30例を対象に、ダサチニブ治療中の免疫細胞数とナチュラルキラー(NK)細胞反応性の変化、免疫学的変化と治療奏効の関連性、大顆粒リンパ球(LGL)の抗CML作用を評価した。さらに、ダサチニブ治療中のLGLおよびNK細胞の拡大に関与する可溶性因子を特定し、LGLリンパ球増加を発症する患者の特性を検討した。NK細胞反応性とLGL数は、ダサチニブ治療中に有意に増強した。NK細胞反応性と制御性TNF細胞数は、ダサチニブ治療の奏効の程度と有意に相関した。ベースラインとダサチニブ治療開始後3、6ヵ月時のT-LGL数には有意な正の相関が認められた。ダサチニブ治療により増強したNK細胞の細胞毒性が抗CML作用の根拠であり、ダサチニブ治療前のT-LGL数はダサチニブ治療の予後的指標となりうることが示唆された。

  • Pericarditis Associated With Human Herpesvirus-6 Reactivation in a Patient After Unrelated Cord Blood Transplant Reviewed

    Yoshida Masahiro, Nakamae Hirohisa, Okamura Hiroshi, Nishimoto Mitsutaka, Hayashi Yoshiki, Koh Hideo, Nakane Takahiko, Hino Masayuki

    EXPERIMENTAL AND CLINICAL TRANSPLANTATION   15 ( 2 )   235 - 238   2017.04( ISSN:1304-0855

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.6002/ect.2014.0261

    PubMed

  • Diagnostic usefulness of plasma presepsin (soluble CD14-subtype) for diagnosing hemophagocytic syndrome in hematological malignancies.

    Koh H, Nanno S, Katayama T, Hirose A, Nakamae M, Hino M, Nakamae H.

    Leuk Lymphoma.   28   1 - 4   2017.02

     More details

    Authorship:Lead author   Publishing type:Research paper (scientific journal)   International / domestic magazine:International journal  

  • An Elderly Woman with Anti-neutrophil Antibody-positive Agranulocytosis Who Responded to High-dose Intravenous Methylprednisolone Reviewed

    Koh Shiro, Koh Hideo, Kubo Yuki, Kuroda Maiko, Nishimoto Mitsutaka, Yoshimura Takuro, Nakashima Yasuhiro, Nakane Takahiko, Nakamae Hirohisa, Ohsawa Masahiko, Hino Masayuki

    一般社団法人 日本内科学会 INTERNAL MEDICINE   56 ( 16 )   2199 - 2203   2017( ISSN:0918-2918

     More details

    Publishing type:Research paper (scientific journal)  

    <p>Although anti-neutrophil antibodies (ANAs) often exist and immunoreaction may be involved in agranulocytosis, few reports have so far described ANA-positive cases of agranulocytosis with an unknown etiology. We herein describe the case of a 69-year-old woman who presented with ANA-positive agranulocytosis. In this case, both the withdrawal of the drugs that had possibly caused neutropenia and the use of granulocyte-colony stimulating factor (G-CSF) were ineffective treatment measures. Approximately 2 weeks after the discontinuation of the suspected drugs, we initiated corticosteroid pulse therapy; the neutrophil count recovered by day 19 of steroid therapy. High-dose methylprednisolone therapy should thus be considered for patients demonstrating ANA-positive agranulocytosis with an unknown etiology that is refractory to G-CSF treatment. </p>

    DOI: 10.2169/internalmedicine.8268-16

    PubMed

    CiNii Article

  • Diagnostic value of serum ferritin and the risk factors and cytokine profiles of hemophagocytic syndrome following allogeneic hematopoietic cell transplantation Reviewed

    Nanno Satoru, Koh Hideo, Nakashima Yasuhiro, Katayama Takako, Okamura Hiroshi, Koh Shiro, Yoshimura Takuro, Nishimoto Mitsutaka, Hayashi Yoshiki, Nakamae Mika, Hirose Asao, Nakane Takahiko, Hino Masayuki, Nakamae Hirohisa

    LEUKEMIA & LYMPHOMA   58 ( 7 )   1664 - 1672   2017( ISSN:1042-8194

     More details

    Authorship:Corresponding author   Publishing type:Research paper (scientific journal)   International / domestic magazine:International journal  

    DOI: 10.1080/10428194.2016.1262034

    PubMed

  • Prophylactic Use of a Combination of an Anticoagulant and Ursodeoxycholic Acid for Sinusoidal Obstruction Syndrome after Allogeneic Myeloablative Hematopoietic Stem Cell Transplantation Reviewed

    Okamura Hiroshi, Nishimoto Mitsutaka, Nakane Takahiko, Koh Hideo, Nakashima Yasuhiro, Takeoka Yasunobu, Nakamae Mika, Hirose Asao, Hino Masayuki, Nakamae Hirohisa

    BLOOD   128 ( 22 )   2016.12( ISSN:0006-4971

     More details

    Publishing type:Research paper (scientific journal)  

  • Short-Term Fasting Induces Cell Cycle Arrest of Immature Hematopoietic Cells and Increases the Number of Naive T Cells in the Bone Marrow of Mice Reviewed

    Takakuwa Teruhito, Nakashima Yasuhiro, Koh Hideo, Nakane Takahiko, Nakamae Hirohisa, Hino Masayuki

    BLOOD   128 ( 22 )   2016.12( ISSN:0006-4971

     More details

    Publishing type:Research paper (scientific journal)  

  • Short-Term Fasting Induces Cell Cycle Arrest of Immature Hematopoietic Cells and Increases the Number of Naive T Cells in the Bone Marrow of Mice Reviewed

    Takakuwa Teruhito, Nakashima Yasuhiro, Koh Hideo, Nakane Takahiko, Nakamae Hirohisa, Hino Masayuki

    BLOOD   128 ( 22 )   2016.12( ISSN:0006-4971

     More details

    Publishing type:Research paper (scientific journal)  

  • Prophylactic Use of a Combination of an Anticoagulant and Ursodeoxycholic Acid for Sinusoidal Obstruction Syndrome after Allogeneic Myeloablative Hematopoietic Stem Cell Transplantation Reviewed

    Okamura Hiroshi, Nishimoto Mitsutaka, Nakane Takahiko, Koh Hideo, Nakashima Yasuhiro, Takeoka Yasunobu, Nakamae Mika, Hirose Asao, Hino Masayuki, Nakamae Hirohisa

    BLOOD   128 ( 22 )   2016.12( ISSN:0006-4971

     More details

    Publishing type:Research paper (scientific journal)  

  • The authors' comments on the editorial by Specht.

    Yoshida M, Koh H, Nakane T, Hino M, Yamane T.

    Eur J Haematol.   97   406   2016.10

     More details

    Publishing type:Research paper (scientific journal)  

  • Combinational approach using in situ hybridization targeting 23S ribosomal RNA genes and blood cultures for bacterial identification in patients with neutropenia and fever.

    Koh H, Aimoto M, Matsuhisa A, Inoue S, Katayama T, et al.

    J Infect Chemother.   22   697 - 703   2016.10

     More details

    Authorship:Lead author   Publishing type:Research paper (scientific journal)   International / domestic magazine:International journal  

  • Prognostic Effect of Low Subcutaneous Adipose Tissue on Survival Outcome in Patients With Multiple Myeloma Reviewed

    Takeoka Yasunobu, Sakatoku Kazuki, Miura Akiko, Yamamura Ryosuke, Araki Taku, Seura Hirotaka, Okamura Terue, Koh Hideo, Nakamae Hirohisa, Hino Masayuki, Ohta Kensuke

    CLINICAL LYMPHOMA MYELOMA & LEUKEMIA   16 ( 8 )   434 - 441   2016.08( ISSN:2152-2650

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.clml.2016.04.010

    PubMed

  • Disseminated Hormographiella aspergillata infection with involvement of the lung, brain, and small intestine following allogeneic hematopoietic stem cell transplantation: case report and literature review Reviewed

    Nanno S., Nakane T., Okamura H., Nishimoto M., Koh H., Nakamae H., Ohsawa M., Yarita K., Kamei K., Hino M.

    TRANSPLANT INFECTIOUS DISEASE   18 ( 4 )   611 - 616   2016.08( ISSN:1398-2273

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/tid.12561

  • Prognostic Effect of Low Subcutaneous Adipose Tissue on Survival Outcome in Patients With Multiple Myeloma.

    Takeoka Y, Sakatoku K, Miura A, Yamamura R, Araki T, Seura H, Okamura T, Koh H, et al.

    Clin Lymphoma Myeloma Leuk.   16   434 - 41   2016.08

     More details

    Publishing type:Research paper (scientific journal)  

  • Lung function score including a parameter of small airway disease as a highly predictive indicator of survival after allogeneic hematopoietic cell transplantation Reviewed

    Nakamae Mika, Yamashita Mariko, Koh Hideo, Nishimoto Mitsutaka, Hayashi Yoshiki, Nakane Takahiko, Nakashima Yasuhiro, Hirose Asao, Hino Masayuki, Nakamae Hirohisa

    TRANSPLANT INTERNATIONAL   29 ( 6 )   707 - 714   2016.06( ISSN:0934-0874

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/tri.12779

    PubMed

  • THE ALTERATION OF IMMUNOPROFILE DURING DASATINIB TREATMENT IN PATIENTS WITH CHRONIC MYELOID LEUKEMIA: A PROSPECTIVE OBSERVATIONAL STUDY Reviewed

    Kuno M., Nakamae H., Katayama T., Nishimoto M., Hayashi Y., Hirose A., Nakamae M., Nakashima Y., Koh H., Nakane T., Hino M.

    HAEMATOLOGICA   101   457 - 457   2016.06( ISSN:0390-6078

     More details

    Publishing type:Research paper (scientific journal)  

  • Analysis of elderly patients with diffuse large B-cell lymphoma: aggressive therapy is a reasonable approach for "unfit' patients classified by comprehensive geriatric assessment Reviewed

    Yoshida Masahiro, Nakao Takafumi, Horiuchi Mirei, Ueda Hideya, Hagihara Kiyoyuki, Kanashima Hiroshi, Inoue Takeshi, Sakamoto Erina, Hirai Manabu, Koh Hideo, Nakane Takahiko, Hino Masayuki, Yamane Takahisa

    EUROPEAN JOURNAL OF HAEMATOLOGY   96 ( 4 )   409 - 416   2016.04( ISSN:0902-4441

     More details

    Publishing type:Research paper (scientific journal)   International / domestic magazine:International journal  

    DOI: 10.1111/ejh.12608

    PubMed

  • Impact of cyclophosphamide dose of conditioning on the outcome of allogeneic hematopoietic stem cell transplantation for aplastic anemia from human leukocyte antigen-identical sibling Reviewed

    Mori Takehiko, Koh Hideo, Onishi Yasushi, Kako Shinichi, Onizuka Makoto, Kanamori Heiwa, Ozawa Yukiyasu, Kato Chiaki, Iida Hiroatsu, Suzuki Ritsuro, Ichinohe Tatsuo, Kanda Yoshinobu, Maeda Tetsuo, Nakao Shinji, Yamazaki Hirohito

    INTERNATIONAL JOURNAL OF HEMATOLOGY   103 ( 4 )   461 - 468   2016.04( ISSN:0925-5710

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s12185-016-1960-z

    PubMed

  • Plasma Levels of Presepsin (Soluble CD14-subtype) as a Novel Prognostic Marker for Hemophagocytic Syndrome in Hematological Malignancies Reviewed

    Nanno Satoru, Koh Hideo, Katayama Takako, Hashiba Masamichi, Sato Ayumi, Makuuchi Yosuke, Nagasaki Joji, Kuno Masatomo, Yoshimura Takuro, Okamura Hiroshi, Nishimoto Mitsutaka, Hirose Asao, Nakamae Mika, Nakane Takahiko, Hino Masayuki, Nakamae Hirohisa

    一般社団法人 日本内科学会 INTERNAL MEDICINE   55 ( 16 )   2173 - 2184   2016( ISSN:0918-2918

     More details

    Publishing type:Research paper (scientific journal)  

    <p><b>Objective </b>Recent studies suggest that presepsin (soluble CD14-subtype) is a useful diagnostic and prognostic marker for sepsis, with secretion by activated macrophages potentially dependent on phagocytosis of microorganisms. As "hemophagocytosis" is one of the major characteristics in patients with hemophagocytic syndrome (HPS), we hypothesized that presepsin may reflect the phagocytic activity and be a useful prognostic marker for HPS. Therefore, we aimed to assess the prognostic potential of presepsin in secondary HPS in adult patients with hematological malignancies. </p><p><b>Methods </b>Between April 2006 and August 2014, we retrospectively examined consecutive patients with HPS whose blood samples were available at our institution and compared the prognostic value of the following in HPS, singly and in combination: plasma presepsin, serum soluble interleukin (IL)-2 receptor (sIL-2R), ferritin, tumor necrosis factor-α (TNF-α), interferon-γ (IFN-γ), IL-6 and IL-10. </p><p><b>Results </b>A total of 14 patients were enrolled. The median age of the patients was 46.5 years (range, 22-65). In univariable Cox models, there were no significant variables associated with the prognosis. However, in 12 evaluable patients, only the combination of higher median values of presepsin (>1,935 pg/mL) and sIL-2R (>4,585 U/mL) at the onset of HPS was significantly associated with the 90-day mortality (hazard ratio 14.5; 95% CI, 1.47-143.36; p=0.02). </p><p><b>Conclusion </b>These results suggest that a composite model of plasma presepsin and serum sIL-2R levels at the onset of HPS might be a novel predictor of the prognosis of patients with hematological malignancies and secondary HPS. </p>

    DOI: 10.2169/internalmedicine.55.6524

    PubMed

    CiNii Article

  • Plasma Kinetics of Th1, Th2 and Th17 Cytokines in Polymyositis Related to Chronic Graft-versus-Host Disease Reviewed

    Koh Shiro, Koh Hideo, Nakashima Yasuhiro, Katayama Takako, Sakabe Manami, Okamura Hiroshi, Yoshimura Takuro, Nanno Satoru, Nishimoto Mitsutaka, Hayashi Yoshiki, Nakane Takahiko, Nakamae Hirohisa, Ohsawa Masahiko, Hino Masayuki

    一般社団法人 日本内科学会 INTERNAL MEDICINE   55 ( 16 )   2265 - 2270   2016( ISSN:0918-2918

     More details

    Publishing type:Research paper (scientific journal)  

    <p>We herein describe a case of myelodysplastic syndrome with chronic graft-versus-host disease (cGVHD)-related polymyositis. On approximately day 1,570 post HLA-identical sibling bone marrow transplant, the patient presented with a fever, myalgia and liver dysfunction. A muscle biopsy revealed destruction of the muscle fibers and infiltration of CD20<sup>+</sup> B cells and CD4<sup>+</sup> and CD8<sup>+</sup> T cells, and a liver biopsy confirmed the findings of cGVHD. An analysis of plasma cytokine profiles indicated elevation of not only T-helper (Th)1 and Th2, but also Th17 cytokines. Increases in these cytokines in addition to the invasion of inflammatory cells might be associated with the pathophysiology of cGVHD involving the muscle and liver. </p>

    DOI: 10.2169/internalmedicine.55.6206

    PubMed

    CiNii Article

  • Diagnostic value of levels of presepsin (soluble CD14-subtype) in febrile neutropenia in patients with hematological disorders Reviewed

    Koh Hideo, Aimoto Mizuki, Katayama Takako, Hashiba Masamichi, Sato Ayumi, Kuno Masatomo, Makuuchi Yosuke, Takakuwa Teruto, Okamura Hiroshi, Hirose Asao, Nakamae Mika, Hino Masayuki, Nakamae Hirohisa

    JOURNAL OF INFECTION AND CHEMOTHERAPY   22 ( 7-8 )   466 - 471   2016( ISSN:1341-321X

     More details

    Authorship:Lead author   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.jiac.2016.04.002

    PubMed

  • Combinational approach using in situ hybridization targeting 23S ribosomal RNA genes and blood cultures for bacterial identification in patients with neutropenia and fever Reviewed

    Koh Hideo, Aimoto Mizuki, Matsuhisa Akio, Inoue Shin-Ichi, Katayama Takako, Okamura Hiroshi, Yoshimura Takuro, Koh Shiro, Nanno Satoru, Nishimoto Mitsutaka, Nakashima Yasuhiro, Hirose Asao, Nakamae Mika, Nakane Takahiko, Hino Masayuki, Nakamae Hirohisa

    JOURNAL OF INFECTION AND CHEMOTHERAPY   22 ( 9-10 )   697 - 703   2016( ISSN:1341-321X

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.jiac.2016.08.001

    PubMed

  • Pre-Transplant Autonomic Nervous System Malfunction Is a Powerful Predictor for Survival after Allogeneic Hematopoietic Cell Transplantation Reviewed

    Nakane Takahiko, Nakamae Mika, Koh Hideo, Nishimoto Mitsutaka, Hayashi Yoshiki, Hirose Asao, Nakashima Yasuhiro, Hino Masayuki, Nakamae Hirohisa

    BLOOD   126 ( 23 )   2015.12( ISSN:0006-4971

     More details

    Publishing type:Research paper (scientific journal)  

  • Efficacy and safety of intra-arterial steroid infusions in patients with steroid-resistant gastrointestinal acute graft-versus-host disease Reviewed

    Nishimoto Mitsutaka, Koh Hideo, Hirose Asao, Nakamae Mika, Nakane Takahiko, Hayashi Yoshiki, Okamura Hiroshi, Yoshimura Takuro, Koh Shiro, Nanno Satoru, Nakashima Yasuhiro, Takeshita Toru, Yamamoto Akira, Sakai Yukimasa, Nishida Norifumi, Matsuoka Toshiyuki, Miki Yukio, Hino Masayuki, Nakamae Hirohisa

    EXPERIMENTAL HEMATOLOGY   43 ( 12 )   995 - 1000   2015.12( ISSN:0301-472X

     More details

    Authorship:Corresponding author   Publishing type:Research paper (scientific journal)   International / domestic magazine:International journal  

    DOI: 10.1016/j.exphem.2015.08.002

    PubMed

  • Pre-Transplant Autonomic Nervous System Malfunction Is a Powerful Predictor for Survival after Allogeneic Hematopoietic Cell Transplantation Reviewed

    Takahiko Nakane, Mika Nakamae, Hideo Koh, Mitsutaka Nishimoto, Yoshiki Hayashi, Asao Hirose, Yasuhiro Nakashima, Masayuki Hino, Hirohisa Nakamae

    BLOOD   126 ( 23 )   2015.12( ISSN:0006-4971

     More details

    Publishing type:Research paper (scientific journal)  

  • HLA haploidentical peripheral blood stem cell transplantation using reduced dose of posttransplantation cyclophosphamide for poor-prognosis or refractory leukemia and myelodysplastic syndrome Reviewed

    Nakamae Hirohisa, Koh Hideo, Katayama Takako, Nishimoto Mitsutaka, Hayashi Yoshiki, Nakashima Yasuhiro, Nakane Takahiko, Nakamae Mika, Hirose Asao, Hino Masayuki

    EXPERIMENTAL HEMATOLOGY   43 ( 11 )   921 - 929   2015.11( ISSN:0301-472X

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.exphem.2015.07.006

    PubMed

  • Effectiveness of antibacterial prophylaxis with non-absorbable polymyxin B compared to levofloxacin after allogeneic hematopoietic stem cell transplantation Reviewed

    Koh S., Yamada K., Nishimoto M., Hayashi Y., Koh H., Nakashima Y., Nakane T., Hirose A., Nakamae M., Kakeya H., Hino M., Nakamae H.

    TRANSPLANT INFECTIOUS DISEASE   17 ( 5 )   647 - 654   2015.10( ISSN:1398-2273

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/tid.12416

  • Pericarditis Associated With Human Herpesvirus-6 Reactivation in a Patient After Unrelated Cord Blood Transplant.

    Yoshida M, Nakamae H, Okamura H, Nishimoto M, Hayashi Y, Koh H, et al.

    Exp Clin Transplant.   2015.10

     More details

    Publishing type:Research paper (scientific journal)  

  • Eosinophilic Crisisを呈する骨髄異形成症候群を合併した視神経炎(Optic Neuritis Associated with Myelodysplastic Syndrome Accompanied by Eosinophilic Crisis) Reviewed

    Nagasaki Joji, Nishimoto Mitsutaka, Nakamae Hirohisa, Nakane Takahiko, Koh Hideo, Yoshimoto Kumiko, Shiraki Kunihiko, Hino Masayuki

    (一社)日本内科学会 Internal Medicine   54 ( 17 )   2241 - 2244   2015.09( ISSN:0918-2918

     More details

    Publishing type:Research paper (scientific journal)  

    症例は64歳男性で、主訴は発熱と疲労であった。末梢血では汎血球減少症が認められ、骨髄検査、形態学的検査、細胞遺伝学的検査から、骨髄異形成症候群(MDS)と確定診断した。MDSの治療計画を行ったが、患者が通院を中断してしまったため、実施することが出来なかった。しかし、3ヵ月後に右眼の視力障害を訴えて入院となり、両眼に軽度核白内障、右眼に相対性求心性瞳孔反応欠損が認められた。蛍光眼底撮影、細隙灯顕微鏡検査所見から、虚血性および非虚血性変化に起因する視神経炎と診断した。血液学的検査では汎血球減少症の改善と末梢血および骨髄で好酸球数の著増が認められたが、視神経炎に対してはメチルプレドニゾロンパルス療法を開始したところ、2週間以内に視神経乳頭浮腫が消失し、末梢血の好酸球数も急速に減少し、視野も部分的に改善が得られた。その後、低用量プレドニゾロンの維持療法が行われているが、視野欠損の悪化もみられず、11ヵ月間良好に維持されている。

  • 初回治療としてCHOP-R療法を選択した縦隔原発大細胞型B細胞性リンパ腫 Reviewed

    田垣内 優美, 西本 光孝, 林 良樹, 幕内 陽介, 久野 雅智, 高桑 輝人, 岡村 浩史, 吉村 卓朗, 康 史朗, 南野 智, 廣瀬 朝生, 中前 美佳, 中嶋 康博, 康 秀男, 中根 孝彦, 中前 博久, 大澤 政彦, 日野 雅之

    「血液診療」編集委員会 血液診療   11 ( 1 )   16 - 20   2015.07

     More details

    Publishing type:Research paper (scientific journal)  

    症例は43歳、女性。前医にて前縦隔腫瘤を指摘され、胸腺癌の疑いで切除術を施行された。術後病理検査の結果、悪性リンパ腫の診断であった。当院にて精査の結果、縦隔原発大細胞型B細胞性リンパ腫(primary mediastinal large B-cell lymphoma、PMBL)の臨床病期IV期と診断した。初回治療としてCHOP-R療法を選択し、現在3コースまで施行し、経過良好である。PMBLはまれな疾患であり、リスク分類および治療選択に関してはまだ十分に確立されていない。今回我々は若年女性に発症した初発PMBLの1例を経験した。初回治療選択および長期治療戦略に関して文献的考察を加えて報告する。(著者抄録)

  • DIAGNOSTIC VALUE OF PLASMA LEVELS OF PRESEPSIN (SOLUBLE CD14-SUBTYPE) FOR FEBRILE NEUTROPENIA IN PATIENTS WITH HEMATOLOGIC MALIGNANCIES Reviewed

    Koh H., Katayama T., Hashiba M., Sato A., Kuno M., Makuuchi Y., Takakuwa T., Okamura H., Hirose A., Nakamae M., Hino M., Nakamae H.

    HAEMATOLOGICA   100   715 - 715   2015.06( ISSN:0390-6078

     More details

    Publishing type:Research paper (scientific journal)  

  • PLASMA LEVELS OF PRESEPSIN (SOLUBLE CD14-SUBTYPE) AS A NOVEL PROGNOSTIC MARKER FOR HEMOPHAGOCYTIC SYNDROME Reviewed

    Nanno S., Koh H., Katayama T., Hashiba M., Sato A., Makuuchi Y., Nagasaki J., Yoshimura T., Okamura H., Nishimoto M., Hirose A., Nakamae M., Nakane T., Hino M., Nakamae H.

    HAEMATOLOGICA   100   557 - 557   2015.06( ISSN:0390-6078

     More details

    Publishing type:Research paper (scientific journal)  

  • Cold autoimmune hemolytic anemia complicated with relapsed myelodysplastic syndrome after allogeneic hematopoietic cell transplantation Reviewed

    OKAMURA Hiroshi, NAKAMAE Hirohisa, HINO Masayuki, NAKANE Takahiko, FUJINO Keizo, KOH Shiro, YOSHIMURA Takuro, NISHIMOTO Mitsutaka, HAYASHI Yoshiki, KOH Hideo, NAKAO Yoshitaka

    The Japanese Society of Hematology, Rinsho Ketsueki   56 ( 4 )   412 - 7   2015.04( ISSN:0485-1439

     More details

    Publishing type:Research paper (scientific journal)  

    Myelodysplastic syndrome (MDS) is known to often be complicated by a range of autoimmune diseases. We herein present a case with MDS complicated by cold autoimmune hemolytic anemia (cold AIHA). The patient was a 51-year-old woman. She was diagnosed with MDS (refractory cytopenia with multilineage dysplasia) in May 2009. In January 2010, she underwent unrelated allogeneic bone marrow transplantation but was re-admitted in October 2010 for treatment of relapsed MDS. Despite daily transfusions of red blood cells, her anemia failed to improve. Her laboratory examinations showed a low haptoglobin level and elevation of indirect bilirubin and LDH. The direct Coombs test was positive at a low and at room temperature and cold agglutinin was negative. After confirming the diagnosis of cold AIHA, all transfusion fluids were warmed but her anemia still failed to improve. In addition to the warmed transfusion fluids, we administered corticosteroids, immunosuppressive agents and high-dose intravenous immunoglobulin infusions. This management strategy ameliorated the patient's hemolytic anemia. To our knowledge, MDS cases complicated by cold AIHA are rare. Our patient thus provides a valuable contribution to medical knowledge.

    DOI: 10.11406/rinketsu.56.412

    PubMed

    CiNii Article

  • Response-guided therapy for steroid-refractory acute GVHD starting with very-low-dose antithymocyte globulin Reviewed

    Nishimoto Mitsutaka, Nakamae Hirohisa, Koh Hideo, Nakamae Mika, Hirose Asao, Hayashi Yoshiki, Nakashima Yasuhiro, Nakane Takahiko, Hino Masayuki

    EXPERIMENTAL HEMATOLOGY   43 ( 3 )   177 - 179   2015.03( ISSN:0301-472X

     More details

    Publishing type:Research paper (scientific journal)   International / domestic magazine:International journal  

    DOI: 10.1016/j.exphem.2014.11.008

    PubMed

  • Drug interaction and safety profiles of concomitant use of caspofungin and tacrolimus in allogeneic hematopoietic stem cell transplant recipients Reviewed

    Nishimoto M., Koh H., Tokuwame A., Makuuchi Y., Kuno M., Takakuwa T., Okamura H., Koh S., Yoshimura T., Nanno S., Hayashi Y., Nakamae M., Hirose A., Nakashima Y., Nakane T., Hino M., Nakamae H.

    BONE MARROW TRANSPLANTATION   50   S408 - S408   2015.03( ISSN:0268-3369

     More details

    Publishing type:Research paper (scientific journal)  

  • Prognostic Value and Clinical Implication of Serum Ferritin Levels following Allogeneic Hematopoietic Cell Transplantation Reviewed

    Nakamae Mika, Nakamae Hirohisa, Koh Shiro, Koh Hideo, Nishimoto Mitsutaka, Nakashima Yasuhiro, Nakane Takahiko, Hirose Asao, Hino Masayuki

    ACTA HAEMATOLOGICA   133 ( 3 )   310 - 316   2015( ISSN:0001-5792

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.1159/000365779

    PubMed

  • P0344-22-AM 同種造血幹細胞移植におけるカスポファンギンとカルシニューリン阻害剤併用時の薬物相互作用および安全性に関する検討(薬物相互作用,ポスター発表,一般演題,医療薬学の進歩と未来-次の四半世紀に向けて-) Reviewed

    徳和目 篤史, 西本 光孝, 高橋 正也, 中村 安孝, 康 秀男, 中前 博久, 西川 武司, 日野 雅之, 永山 勝也

    一般社団法人 日本医療薬学会 日本医療薬学会年会講演要旨集   25 ( 0 )   2015

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.20825/amjsphcs.25.0_323_2

    CiNii Article

  • Optic Neuritis Associated with Myelodysplastic Syndrome Accompanied by Eosinophilic Crisis Reviewed

    Nagasaki Joji, Nishimoto Mitsutaka, Nakamae Hirohisa, Nakane Takahiko, Koh Hideo, Yoshimoto Kumiko, Shiraki Kunihiko, Hino Masayuki

    一般社団法人 日本内科学会 INTERNAL MEDICINE   54 ( 17 )   2241 - 2244   2015( ISSN:0918-2918

     More details

    Publishing type:Research paper (scientific journal)  

    Myelodysplastic syndrome (MDS) was diagnosed in a 64-year-old man. Three months later, he presented with right-sided visual loss. A diagnosis of optic neuritis caused by both ischemic and non-ischemic changes was established. Concurrently, prominent eosinophilia was seen in both the peripheral blood and bone marrow. A partial improvement of visual loss was obtained concomitant with a rapid decrease of the eosinophils after treatment with corticosteroids. Optic neuritis related to MDS is a rare condition and its etiology has not yet been identified. We herein report a case of optic neuritis associated with MDS and accompanied by an eosinophilic crisis.<br>

    DOI: 10.2169/internalmedicine.54.4148

    PubMed

    CiNii Article

  • Effectiveness of Antibacterial Prophylaxis with Non-Absorbable Polymyxin B Compared to Levofloxacin after Allogeneic Hematopoietic Stem Cell Transplantation Reviewed

    Koh Shiro, Nakamae Hirohisa, Yamada Koichi, Nishimoto Mitsutaka, Hayashi Yoshiki, Koh Hideo, Nakashima Yasuhiro, Nakane Takahiko, Hirose Asao, Nakamae Mika, Kakeya Hiroshi, Hino Masayuki

    BLOOD   124 ( 21 )   2014.12( ISSN:0006-4971

     More details

    Publishing type:Research paper (scientific journal)  

  • The V50/V25 Ratio, a Marker of Small Airway Disease, Is Highly Predictive of Survival after Allogeneic Hematopoietic Cell Transplantation Reviewed

    Nakamae Mika, Nakamae Hirohisa, Yamashita Mariko, Nishimoto Mitsutaka, Hayashi Yoshiki, Koh Hideo, Nakane Takahiko, Nakashima Yasuhiro, Hirose Asao, Hino Masayuki

    BLOOD   124 ( 21 )   2014.12( ISSN:0006-4971

     More details

    Publishing type:Research paper (scientific journal)  

  • The V50/V25 Ratio, a Marker of Small Airway Disease, Is Highly Predictive of Survival after Allogeneic Hematopoietic Cell Transplantation Reviewed

    Nakamae Mika, Nakamae Hirohisa, Yamashita Mariko, Nishimoto Mitsutaka, Hayashi Yoshiki, Koh Hideo, Nakane Takahiko, Nakashima Yasuhiro, Hirose Asao, Hino Masayuki

    BLOOD   124 ( 21 )   2014.12( ISSN:0006-4971

     More details

    Publishing type:Research paper (scientific journal)  

  • Effectiveness of Antibacterial Prophylaxis with Non-Absorbable Polymyxin B Compared to Levofloxacin after Allogeneic Hematopoietic Stem Cell Transplantation Reviewed

    Koh Shiro, Nakamae Hirohisa, Yamada Koichi, Nishimoto Mitsutaka, Hayashi Yoshiki, Koh Hideo, Nakashima Yasuhiro, Nakane Takahiko, Hirose Asao, Nakamae Mika, Kakeya Hiroshi, Hino Masayuki

    BLOOD   124 ( 21 )   2014.12( ISSN:0006-4971

     More details

    Publishing type:Research paper (scientific journal)  

  • Diagnostic performance of serum high-sensitivity procalcitonin and serum C-reactive protein tests for detecting bacterial infection in febrile neutropenia Reviewed

    Aimoto Mizuki, Koh Hideo, Katayama Takako, Okamura Hiroshi, Yoshimura Takuro, Koh Shiro, Nanno Satoru, Nishimoto Mitsutaka, Hirose Asao, Nakamae Mika, Nakane Takahiko, Nakamae Hirohisa, Kakeya Hiroshi, Hino Masayuki

    INFECTION   42 ( 6 )   971 - 979   2014.12( ISSN:0300-8126

     More details

    Authorship:Corresponding author   Publishing type:Research paper (scientific journal)   International / domestic magazine:International journal  

    DOI: 10.1007/s15010-014-0657-6

    PubMed

  • Cerebral infarction in the left hemisphere compared with the right hemisphere increases the risk of aspiration pneumonia. Reviewed

    Yamamoto K, Koh H, Shimada H, Takeuchi J, Yamakawa Y, Kawamura M, Miki T

    Osaka city medical journal   60 ( 2 )   81 - 6   2014.12( ISSN:0030-6096

     More details

    Publishing type:Research paper (scientific journal)  

    PubMed

  • 右半球と比較して左半球での脳梗塞は誤嚥性肺炎のリスクを増加させる(Cerebral Infarction in the Left Hemisphere Compared with the Right Hemisphere Increases the Risk of Aspiration Pneumonia) Reviewed

    Yamamoto Keiichi, Koh Hideo, Shimada Hiroyuki, Takeuchi Jun, Yamakawa Yoshihiro, Kawamura Mayumi, Miki Takami

    大阪市医学会 Osaka City Medical Journal   60 ( 2 )   81 - 86   2014.12( ISSN:0030-6096

     More details

    Publishing type:Research paper (scientific journal)  

  • Feasibility of umbilical cord blood transplantation with a myeloablative, reduced toxicity-conditioning regimen Reviewed

    Nishimoto M., Nakamae H., Nakamae M., Hirose A., Hagihara K., Koh H., Nakane T., Terada Y., Hino M.

    BONE MARROW TRANSPLANTATION   49 ( 7 )   980 - 981   2014.07( ISSN:0268-3369

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/bmt.2014.60

  • Serum levels of albumin-amyloid beta complexes are decreased in Alzheimer's disease Reviewed

    Yamamoto Keiichi, Shimada Hiroyuki, Koh Hideo, Ataka Suzuka, Miki Takami

    GERIATRICS & GERONTOLOGY INTERNATIONAL   14 ( 3 )   716 - 723   2014.07( ISSN:1444-1586

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/ggi.12147

    PubMed

  • IMPACT OF DOSE INTENSITY OF CONDITIONING ON THE OUTCOMES OF ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION FOR SEVERE APLASTIC ANEMIA FROM AN HLA-IDENTICAL SIBLING Reviewed

    Mori T., Koh H., Onishi Y., Kako S., Onizuka M., Kanamori H., Miyamura K., Uchida N., Kato C., Iida H., Suzuki R., Ichinohe T., Atsuta Y., Nakao S., Yamazaki H.

    HAEMATOLOGICA   99   167 - 168   2014.06( ISSN:0390-6078

     More details

    Publishing type:Research paper (scientific journal)  

  • Posterior reversible encephalopathy syndrome following acute pancreatitis during chemotherapy for acute monocytic leukemia. Reviewed

    Nishimoto M, Koh H, Bingo M, Yoshida M, Nanno S, Hayashi Y, Nakane T, Nakamae H, Shimono T, Hino M

    [Rinsho ketsueki] The Japanese journal of clinical hematology   55 ( 5 )   552 - 7   2014.05( ISSN:0485-1439

     More details

    Publishing type:Research paper (scientific journal)  

    PubMed

  • Evans症候群罹患後20年を経過して発症した溶血発作を伴うdiffuse large B-cell lymphoma Reviewed

    吉村 卓朗, 中根 孝彦, 亀崎 豊実, 稲葉 晃子, 西本 光孝, 向井 悟, 坂部 真奈美, 大澤 政彦, 藤野 惠三, 康 秀男, 中尾 吉孝, 中前 博久, 日野 雅之

    (一社)日本血液学会-東京事務局 臨床血液   55 ( 5 )   546 - 551   2014.05( ISSN:0485-1439

     More details

    Publishing type:Research paper (scientific journal)  

    症例は65歳女性,1992年5月にクームス試験陽性自己免疫性溶血性貧血と赤芽球癆の合併と診断された。その後赤芽球癆は改善したが,新たに血小板減少を認め,骨髄検査にて特発性血小板減少性紫斑病の合併と考えられ,Evans症候群と診断された。Prednisoloneおよびazathioprineを投与し軽快,以後約20年に渡り投薬を漸減しつつ寛解増悪を繰り返していた。2012年10月,溶血発作の再増悪とB症状及びリンパ節腫脹が出現した。リンパ節生検の結果DLBCLと診断された。一方クームス試験は陰性,精査にてクームス陰性自己免疫性溶血性貧血も否定的であり,リンパ腫に関連した他の原因による溶血の可能性が疑われた。CHOP療法を施行したところ,溶血およびB症状は改善し,リンパ節病変も縮小を認めた。Evans症候群後DLBCLの発症の報告は稀であり,示唆に富む症例と考えられ,今回報告する。(著者抄録)

  • Diffuse large B-cell lymphoma with hemolytic crisis developed twenty years after the onset of Evans syndrome. Reviewed

    Yoshimura T, Nakane T, Kamesaki T, Inaba A, Nishimoto M, Mukai S, Sakabe M, Ohsawa M, Fujino K, Koh H, Nakao Y, Nakamae H, Hino M

    [Rinsho ketsueki] The Japanese journal of clinical hematology   55 ( 5 )   546 - 51   2014.05( ISSN:0485-1439

     More details

    Publishing type:Research paper (scientific journal)  

    PubMed

  • Serum butyrylcholinesterase and the risk of future type 2 diabetes: the Kansai Healthcare Study.

    Sato KK, Hayashi T, Maeda I, Koh H, Harita N, Uehara S, et al.

    Clin Endocrinol (Oxf).   80   362 - 7   2014.05

     More details

    Publishing type:Research paper (scientific journal)  

  • Cerebral toxoplasmosis after umbilical cord blood transplantation diagnosed by the detection of anti-toxoplasma specific IgM antibody in cerebrospinal fluid.

    Inaba A, Koh H, Nakashima Y, Nishimoto M, Hayashi Y, Okamura H, et al.

    55   456 - 60   2014.04

     More details

    Publishing type:Research paper (scientific journal)  

  • DIAGNOSTIC VALUE OF SERUM FERRITIN AND RISK FACTORS FOR HEMOPHAGOCYTIC SYNDROME FOLLOWING ALLOGENEIC HEMATOPOIETIC CELL TRANSPLANTATION Reviewed

    Nanno S., Koh H., Nakashima Y., Katayama T., Kuno M., Makuuchi Y., Nagasaki J., Takakuwa T., Okamura H., Koh S., Yoshimura T., Nishimoto M., Nakamae M., Hirose A., Nakane T., Nakao Y., Nakamae H., Hino M.

    BONE MARROW TRANSPLANTATION   49   S472 - S473   2014.03( ISSN:0268-3369

     More details

    Publishing type:Research paper (scientific journal)  

  • Serum butyrylcholinesterase and the risk of future type 2 diabetes: the Kansai Healthcare Study Reviewed

    Sato Kyoko Kogawa, Hayashi Tomoshige, Maeda Isseki, Koh Hideo, Harita Nobuko, Uehara Shinichiro, Onishi Yukiko, Oue Keiko, Nakamura Yoshiko, Endo Ginji, Kambe Hiroshi, Fukuda Kanji

    CLINICAL ENDOCRINOLOGY   80 ( 3 )   362 - 367   2014.03( ISSN:0300-0664

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/cen.12171

    PubMed

  • PROMISING OUTCOMES FROM INTRA-ARTERIAL STEROID INFUSIONS IN PATIENTS WITH TREATMENT-RESISTANT ACUTE GASTROINTESTINAL GRAFT-VERSUS-HOST DISEASE Reviewed

    Nishimoto M., Koh H., Nakamae H., Hirose A., Nakamae M., Nakane T., Hayashi Y., Okamura H., Yoshimura T., Koh S., Nanno S., Nakashima Y., Takeshita T., Yamamoto A., Sakai Y., Nishida N., Matsuoka T., Miki Y., Hino M.

    BONE MARROW TRANSPLANTATION   49   S278 - S279   2014.03( ISSN:0268-3369

     More details

    Publishing type:Research paper (scientific journal)  

  • Diffuse large B-cell lymphoma with hemolytic crisis developed twenty years after the onset of Evans syndrome Reviewed

    YOSHIMURA Takuro, KOH Hideo, NAKAO Yoshitaka, NAKAMAE Hirohisa, HINO Masayuki, NAKANE Takahiko, KAMESAKI Toyomi, INABA Akiko, NISHIMOTO Mitsutaka, MUKAI Satoru, SAKABE Manami, OHSAWA Masahiko, FUJINO Keizo

    The Japanese Society of Hematology, Rinsho Ketsueki   55 ( 5 )   546 - 551   2014( ISSN:0485-1439

     More details

    Publishing type:Research paper (scientific journal)  

    A 65-year-old woman was diagnosed with Coombs-positive autoimmune hemolytic anemia (AIHA) and pure red cell aplasia (PRCA) in May 1992. One month later, her PRCA went into remission following treatment but she developed idiopathic thrombocytopenic purpura and was diagnosed with Evans syndrome. Although her condition resolved with administration of prednisolone and azathioprine, it was necessary to continue treatment with gradual tapering over the following two decades. In October 2012, her hemolytic anemia again worsened, and lymph node swelling, splenomegaly and B symptoms developed. She was diagnosed as having diffuse large B-cell lymphoma (DLBCL) based on lymph node biopsy. However, AIHA was not considered to be the cause of her hemolytic anemia, but rather to be related to DLBCL. This was because a Coombs test and other extensive investigations for Coombs negative-AIHA yielded negative results. The patient underwent CHOP therapy, and all of her symptoms improved. Herein, we report this rare case in which DLBCL developed after the onset of Evans syndrome.

    DOI: 10.11406/rinketsu.55.546

    CiNii Article

  • Posterior reversible encephalopathy syndrome following acute pancreatitis during chemotherapy for acute monocytic leukemia Reviewed

    NISHIMOTO Mitsutaka, HINO Masayuki, KOH Hideo, BINGO Masato, YOSHIDA Masahiro, NANNO Satoru, HAYASHI Yoshiki, NAKANE Takahiko, NAKAMAE Hirohisa, SHIMONO Taro

    The Japanese Society of Hematology, Rinsho Ketsueki   55 ( 5 )   552 - 557   2014( ISSN:0485-1439

     More details

    Publishing type:Research paper (scientific journal)  

    We describe an 18-year-old man with acute leukemia who presented with posterior reversible encephalopathy syndrome (PRES) shortly after developing acute pancreatitis. On day 15 after the third consolidation course with high-dose cytarabine, treatment with broad-spectrum antibiotics was initiated for febrile neutropenia. On day 16, he developed septic shock, and subsequently, acute respiratory distress syndrome (ARDS). After adding vancomycin, micafungin and high-dose methylprednisolone (mPSL) to his treatment regimen, these manifestations subsided. On day 22, he received hemodialysis for drug-induced acute renal failure. On day 24, he developed acute pancreatitis possibly due to mPSL; the following day he had generalized seizures, and was intubated. Cerebrospinal fluid findings were normal. Brain MRI revealed hyperintense signals on FLAIR images and increased apparent diffusion coefficient values in the sub-cortical and deep white matter areas of the bilateral temporal and occipital lobes, indicative of vasogenic edema. Thus, we diagnosed PRES. Blood pressure, seizures and volume status were controlled, with MRI findings showing improvement by day 42. He was extubated on day 32 and discharged on day 49 without complications. Although little is known about PRES following acute pancreatitis, clinicians should be aware that this condition may develop.

    DOI: 10.11406/rinketsu.55.552

    CiNii Article

  • Cerebral toxoplasmosis after umbilical cord blood transplantation diagnosed by the detection of anti-toxoplasma specific IgM antibody in cerebrospinal fluid Reviewed

    INABA Akiko, SHIMONO Taro, NAKAMAE Hirohisa, HINO Masayuki, KOH Hideo, NAKASHIMA Yasuhiro, NISHIMOTO Mitsutaka, HAYASHI Yoshiki, OKAMURA Hiroshi, INOUE Atsushi, NANNO Satoru, NAKANE Takahiko

    The Japanese Society of Hematology, Rinsho Ketsueki   55 ( 4 )   456 - 460   2014( ISSN:0485-1439

     More details

    Publishing type:Research paper (scientific journal)  

    Cerebral toxoplasmosis is a rare, potentially fatal, complication of hematopoietic cell transplantation. Early definitive diagnosis is very difficult and it may be associated with a poor prognosis. Herein, we describe a 60-year-old woman who developed cerebral toxoplasmosis after cord blood transplantation for myelodysplastic syndrome. During treatment with tacrolimus and methylprednisolone for relapsed grade 2 acute gut GVHD, fever and disturbance of consciousness occurred on day 210. Brain MRI showed multiple ring-enhancing nodular lesions in the thalamus, basal ganglia, brainstem, and subcortical white matter. Cerebrospinal fluid (CSF) assessment revealed elevations of both anti-to-xoplasma IgM and IgG, which were also elevated in serum, but no evidence of other infections or malignancies. Notably, the IgM level was higher in the CSF than in serum. Thus, cerebral toxoplasmosis was diagnosed. Soon after administration of oral sulfamethoxazole/trimethoprim and intravenous clindamycin in combination with short-term dexamethasone for the cerebral edema, her symptoms and signs began to improve. On day 229, both IgM and IgG titers in CSF had clearly decreased but remained essentially constant in serum. She was discharged without clinically significant neurological disorders. This case suggests that CSF specific anti-toxoplasma IgM titers might be useful for early diagnosis of cerebral toxoplasmosis after transplantation.

    DOI: 10.11406/rinketsu.55.456

    CiNii Article

  • Empirical voriconazole therapy for febrile neutropenic patients with hematological disorders: a prospective multicenter trial in Japan Reviewed

    Koh Hideo, Hino Masayuki, Ohta Kensuke, Iino Masaki, Urase Fumiaki, Yamaguchi Masaki, Yamanouchi Jun, Usui Noriko, Yoshida Minoru, Tanimoto Mitsune, Ohyashiki Kazuma, Urabe Akio, Tamura Kazuo, Kanamaru Akihisa, Masaoka Tohru

    JOURNAL OF INFECTION AND CHEMOTHERAPY   19 ( 6 )   1126 - 1134   2013.12( ISSN:1341-321X

     More details

    Authorship:Lead author, Corresponding author   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s10156-013-0634-5

    PubMed

  • Refractoriness to platelet transfusion in acute myeloid leukemia correlated with the optical density of anti-platelet factor 4/heparin antibodies Reviewed

    Aimoto Mizuki, Yamane Takahisa, Shiomoto Kazumasa, Sakamoto Chikahiko, Nakashima Yasuhiro, Koh Hideo, Nakane Takahiko, Takeoka Yasunobu, Hirose Asao, Nakamae Mika, Hagihara Kiyoyuki, Terada Yoshiki, Nakao Yoshitaka, Nakamae Hirohisa, Hino Masayuki, Miyata Shigeki

    INTERNATIONAL JOURNAL OF HEMATOLOGY   98 ( 4 )   472 - 477   2013.10( ISSN:0925-5710

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s12185-013-1427-4

    PubMed

  • 急性骨髄性白血病における血小板輸血不応状態は抗血小板第4因子/ヘパリン複合体抗体の吸光度と相関する(Refractoriness to platelet transfusion in acute myeloid leukemia correlated with the optical density of anti-platelet factor 4/heparin antibodies) Reviewed

    Aimoto Mizuki, Yamane Takahisa, Shiomoto Kazumasa, Sakamoto Chikahiko, Nakashima Yasuhiro, Koh Hideo, Nakane Takahiko, Takeoka Yasunobu, Hirose Asao, Nakamae Mika, Hagihara Kiyoyuki, Terada Yoshiki, Nakao Yoshitaka, Nakamae Hirohisa, Hino Masayuki, Miyata Shigeki

    (一社)日本血液学会 International Journal of Hematology   98 ( 4 )   472 - 477   2013.10( ISSN:0925-5710

     More details

    Publishing type:Research paper (scientific journal)  

    66歳女性。10日前に発熱および上気道症状が出現し、他院にて肺炎および急性骨髄性白血病(AML)と診断され、当院に転院となった。血小板輸血を行うも血小板数低値が持続し、ヒト白血球抗原(HLA)適合血小板輸血、副腎皮質ステロイド投与、高用量免疫グロブリン静注を行っても血小板輸血不応状態は改善しなかった。へパリン起因性血小板減少症の可能性を考慮し、9日目にヘパリンフラッシュを中止、ELISA法にて抗血小板第4因子(PF4)/ヘパリン複合体抗体を測定したところ、吸光度(OD)は2.1と高値を示した。21日目(ヘパリンフラッシュ中止12日後)に血小板輸血不応状態は消散し、AMLに対する化学療法を開始した。2コース実施後に完全寛解が得られたが、地固め療法実施下で再発をきたし死亡した。その後の検討で、抗PF4/ヘパリン複合体抗体のOD値の漸減と、OD値が1.0未満へ至ったときに血小板輸血不応状態が消散していた。

  • Successful Treatment of Both Acute Leukemia and Active Crohn's Disease After Allogeneic Hematopoietic Stem Cell Transplantation Using Reduced-Intensity Conditioning With Fludarabine and Busulfan: A Case Report Reviewed

    Nishimoto M., Nakamae H., Watanabe K., Koh H., Nakane T., Ohsawa M., Arakawa T., Hino M.

    TRANSPLANTATION PROCEEDINGS   45 ( 7 )   2854 - 2857   2013.09( ISSN:0041-1345

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.transproceed.2013.03.049

  • Angioimmunoblastic T cell lymphoma complicated with endocapillary proliferative glomerulonephritis Reviewed

    NANNO Satoru, MAKAMAE Hirohisa, KUWAMURA Yukinobu, ISHIMURA Eiji, SAKABE Manami, INABA Akiko, KOH Shiro, YOSHIMURA Takuro, NISHIMOTO Mitsutaka, HAYASHI Yoshiki, TERADA Yoshiki, NAKANE Takahiko, KOH Hideo, NAKAO Yoshitaka, OHSAWA Masahiko, HINO Masayuki

    The Japanese Society of Hematology, Rinsho Ketsueki   54 ( 7 )   658 - 663   2013.07( ISSN:04851439

     More details

    Publishing type:Research paper (scientific journal)  

    A 30-year-old female developed fever and multiple lymphadenopathy in September 2011. Her symptoms improved with antibiotic treatment. However, she again presented with fever and multiple lymphadenopathy in December 2011. In addition, she suffered from nephrotic syndrome with severe edema. She was therefore hospitalized to undergo detailed examinations. Renal biopsy revealed endocapillary proliferative glomerulonephritis. Since her renal function deteriorated rapidly, she was given steroid pulse therapy with methylprednisolone, followed by maintenance therapy with prednisolone. After treatment, her renal function improved but multiple lymphadenopathy persisted. Biopsy of a left axillary lymph node was then performed and revealed angioimmunoblastic T-cell lymphoma (AITL). She received CHOP therapy but showed no response. Therefore, she was given ESHAP therapy. A partial response was achieved and the nephrotic syndrome also resolved completely. We report this extremely rare case of renal dysfunction due to endocapillary proliferative glomerulonephritis complicated by AITL.

    DOI: 10.11406/rinketsu.54.658

    CiNii Article

  • Prognostic factors and outcomes of unrelated bone marrow transplantation for Philadelphia chromosome positive acute lymphoblastic leukemia (Ph+ALL) pre-treated with tyrosine kinase inhibitors. Reviewed

    Yoshimura T, Nakane T, Hirose A, Koh H, Nakamae M, Aimoto M, Nishimoto M, Hayashi Y, Terada Y, Nakamae H, Hino M

    Osaka city medical journal   59 ( 1 )   9 - 21   2013.06( ISSN:0030-6096

     More details

    Publishing type:Research paper (scientific journal)  

    PubMed

  • チロシンキナーゼ阻害薬で事前治療を受けていたフィラデルフィア染色体陽性急性リンパ芽球性白血病(Ph+ALL)に対する非血縁者からの骨髄移植の予後予測因子と治療成績(Prognostic Factors and Outcomes of Unrelated Bone Marrow Transplantation for Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia(Ph+ALL) Pre-treated with Tyrosine Kinase Inhibitors) Reviewed

    Yoshimura Takuro, Nakane Takahiko, Hirose Asao, Koh Hideo, Nakamae Mika, Aimoto Mizuki, Nishimoto Mitsutaka, Hayashi Yoshiki, Terada Yoshiki, Nakamae Hirohisa, Hino Masayuki

    大阪市医学会 Osaka City Medical Journal   59 ( 1 )   9 - 21   2013.06( ISSN:0030-6096

     More details

    Publishing type:Research paper (scientific journal)  

  • Acute myeloid leukemia with monosomy 7 and inv(3) (q21q26.2) complicated with central diabetes insipidus Reviewed

    NANNO Satoru, HAGIHARA Kiyoyuki, SAKABE Manami, OKAMURA Hiroshi, INABA Akiko, NAGATA Yuki, NISHIMOTO Mitsutaka, KOH Hideo, NAKAO Yoshitaka, NAKANE Takahiko, NAKAMAE Hirohisa, SHIMONO Taro, HINO Masayuki

    The Japanese Society of Hematology, Rinsho Ketsueki   54 ( 4 )   397 - 402   2013.04( ISSN:04851439

     More details

    Publishing type:Research paper (scientific journal)  

    A 20-year-old female presented with thirst, polyposia, and polyuria and was referred to our hospital because of leukocytosis and anemia. Bone marrow aspiration revealed 66.8% myeloperoxidase-positive blasts and trilineage myelodysplasia. The karyotype was 45, XX, inv(3)(q21q26.2), -7[19]. Therefore, a diagnosis of AML with inv(3)(q21q26.2) complicated by -7 was made. Moreover, hyposthenuria and a low anti-diuretic hormone (ADH) level were observed. Although cerebrospinal fluid analysis was normal, magnetic resonance imaging (MRI) revealed the absence of hyperintensity in the neurohypophysis in T1-weighted images. Therefore, she was also diagnosed with diabetes insipidus. After she was administered a desmopressin nasal spray, the volume of urine produced decreased. Following treatment with second induction therapy containing high-dose cytarabine for AML, she achieved complete remission in the bone marrow. Moreover, when the abnormality on MRI and the volume of urine were normalized, she discontinued desmopressin. Although diabetes insipidus is a rare complication of AML, the majority of AML patients who have diabetes insipidus have the abnormal karyotypes with inv(3)(q21q26.2)/t(3;3)(q21;q26.2) and monosomy 7. Further study is required to clarify the pathogenesis and develop a strategy for the treatment of this category of AML.

    DOI: 10.11406/rinketsu.54.397

    CiNii Article

  • Risk factors affecting cardiac left-ventricular hypertrophy and systolic and diastolic function in the chronic phase of allogeneic hematopoietic cell transplantation Reviewed

    Nishimoto M., Nakamae H., Koh H., Nakane T., Nakamae M., Hirose A., Hagihara K., Nakao Y., Terada Y., Ohsawa M., Hino M.

    BONE MARROW TRANSPLANTATION   48 ( 4 )   581 - 586   2013.04( ISSN:0268-3369

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/bmt.2012.179

  • 同種骨髄移植後に急性横断性脊髄炎を合併した急性リンパ性白血病 Reviewed

    間部 賢寛, 西本 光孝, 伊藤 和博, 岡村 浩史, 備後 真登, 吉田 全宏, 井上 敦司, 相本 瑞樹, 林 良樹, 康 秀男, 中根 孝彦, 中前 美佳, 寺田 芳樹, 中前 博久, 中尾 隆文, 高 起良, 平井 学, 中尾 吉孝, 山根 孝久, 日野 雅之

    (株)癌と化学療法社 癌と化学療法   40 ( 4 )   529 - 532   2013.04( ISSN:0385-0684

     More details

    Publishing type:Research paper (scientific journal)  

    症例は40歳、女性。分子学的寛解を得たPhiladelphia染色体陽性急性リンパ性白血病に対して、非血縁者間骨髄移植を実施した。day 90ごろより知覚異常、膀胱直腸障害および下肢筋力低下を認め、MRI所見も含めて急性横断性脊髄炎と診断した。ステロイドパルスおよび免疫グロブリン製剤投与を行い、症状の改善を得た。横断性脊髄炎は運動、知覚および自律神経系に異常を来す炎症性疾患であるが、造血幹細胞移植での合併例は比較的まれである。早期の診断および治療開始が機能的予後に影響するため、移植後の脊髄症には急性横断性脊髄炎を鑑別診断として念頭に置く必要性がある。(著者抄録)

  • Dasatinib Maintenance Therapy after Allogeneic Hematopoietic Stem Cell Transplantation for an Isolated Central Nervous System Blast Crisis in Chronic Myelogenous Leukemia Reviewed

    Nishimoto Mitsutaka, Nakamae Hirohisa, Koh Ki-Ryang, Kosaka Saori, Matsumoto Kana, Morita Kunihiko, Koh Hideo, Nakane Takahiko, Ohsawa Masahiko, Hino Masayuki

    ACTA HAEMATOLOGICA   130 ( 2 )   111 - 114   2013( ISSN:0001-5792

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.1159/000347158

    PubMed

  • Use of per Rectal Portal Scintigraphy to Detect Portal Hypertension in Sinusoidal Obstructive Syndrome following Unrelated Cord Blood Transplantation Reviewed

    Okamura Hiroshi, Hayashi Yoshiki, Nakamae Hirohisa, Shiomi Susumu, Nishimoto Mitsutaka, Koh Hideo, Nakane Takahiko, Hino Masayuki

    ACTA HAEMATOLOGICA   130 ( 2 )   83 - 86   2013( ISSN:0001-5792

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.1159/000346438

    PubMed

  • Fatal BK virus pneumonia following stem cell transplantation Reviewed

    Akazawa Y., Terada Y., Yamane T., Tanaka S., Aimoto M., Koh H., Nakane T., Koh K. -R., Nakamae H., Ohsawa M., Wakasa K., Hino M.

    TRANSPLANT INFECTIOUS DISEASE   14 ( 6 )   E142 - E146   2012.12( ISSN:1398-2273

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/tid.12011

  • Prognostic Value for Survival of Serum Ferritin Levels Over Time After Allogeneic Hematopoietic Cell Transplantation Reviewed

    Nakamae Mika, Nakamae Hirohisa, Koh Hideo, Nakane Takahiko, Nishimoto Mitsutaka, Hirose Asao, Hino Masayuki

    BLOOD   120 ( 21 )   2012.11( ISSN:0006-4971

     More details

    Publishing type:Research paper (scientific journal)  

  • IMMUNOGLOBULIN PROPHYLAXIS AGAINST CYTOMEGALOVIRUS INFECTION IN PATIENTS AT HIGH RISK OFINFECTION FOLLOWING ALLOGENEIC HEMATOPOIETIC CELL TRANSPLANTATION Reviewed

    Ichihara H., Nakamae H., Hirose A., Nakane T., Koh H., Hayashi Y., Nisimoto M., Nakamae M., Terada Y., Koh S., Yoshimura T., Aimoto M., Manabe M., Hagiwara K., Hino M.

    ANNALS OF ONCOLOGY   23   167 - 167   2012.10( ISSN:0923-7534

     More details

    Publishing type:Research paper (scientific journal)  

  • 初発症候性多発性骨髄腫に対するデキサメタゾン大量療法先行ボルテゾミブ・デキサメタゾン併用療法の効果 Reviewed

    小坂 さおり, 山村 亮介, 康 秀男, 稲葉 晃子, 荒木 拓, 藤谷 洋太朗, 武岡 康信, 洪 鉉寿, 太田 健介

    (株)医薬情報研究所 新薬と臨牀   61 ( 9 )   1734 - 1742   2012.09( ISSN:0559-8672

     More details

    Publishing type:Research paper (scientific journal)  

    当院で治療を受けた初発症候性多発性骨髄腫51例について、ボルテゾミブとデキサメタゾン併用療法(BD療法)が全く実施されなかった群(Non-Bor群、15例)、狭義の再発・難治症例に対して実施された群(RR-Bor群、17例)、および、初回治療として短期間のDex大量療法(HD-Dex)を先行させた上で早期に実施された群(Upfront-Bor群、19例)に分けて、治療成績を後方視的に検討した。RR-Bor群とUpfront-Bor群のVGPR以上の奏効率は、それぞれ17.6%と31.6%で、PFSもUpfront-Bor群がRR-Bor群に対して有意に優れていた(p=0.039、ハザード比0.39)。3群間でOSには差を認めなかった。また、Upfront-Bor群における先行HD-DexはM蛋白量を約30%減少させ、腫瘍崩解症候群などの重篤な合併症のリスクを軽減させる可能性が示唆された。(著者抄録)

  • Different immunoprofiles in patients with chronic myeloid leukemia treated with imatinib, nilotinib or dasatinib Reviewed

    Hayashi Yoshiki, Nakamae Hirohisa, Katayama Takako, Nakane Takahiko, Koh Hideo, Nakamae Mika, Hirose Asao, Hagihara Kiyoyuki, Terada Yoshiki, Nakao Yoshitaka, Hino Masayuki

    LEUKEMIA & LYMPHOMA   53 ( 6 )   1084 - 1089   2012.06( ISSN:1042-8194

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.3109/10428194.2011.647017

    PubMed

  • Relationship between drinking patterns and the risk of type 2 diabetes: the Kansai Healthcare Study Reviewed

    Sato Kyoko Kogawa, Hayashi Tomoshige, Harita Nobuko, Koh Hideo, Maeda Isseki, Endo Ginji, Nakamura Yoshiko, Kambe Hiroshi, Kiyotaki Chiharu

    JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH   66 ( 6 )   507 - 511   2012.06( ISSN:0143-005X

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.1136/jech.2010.109777

    PubMed

  • Prolonged Sinus Tachycardia Caused by Human Herpesvirus 6 (HHV6) Encephalomyelitis after Allogeneic Bone Marrow Transplantation Reviewed

    Nishimoto Mitsutaka, Nakamae Hirohisa, Hayashi Yoshiki, Koh Hideo, Nakane Takahiko, Yoshida Masahiro, Bingo Masato, Okamura Hiroshi, Aimoto Mizuki, Nanno Satoru, Yoshimura Takuro, Inaba Akiko, Hagihara Kiyoyuki, Nakamae Mika, Hirose Asao, Nakao Yoshitaka, Terada Yoshiki, Hino Masayuki

    一般社団法人 日本内科学会 INTERNAL MEDICINE   51 ( 10 )   1265 - 1267   2012( ISSN:0918-2918

     More details

    Publishing type:Research paper (scientific journal)  

    A 19-year-old man with Philadelphia chromosome-positive acute lymphoblastic leukemia received an allogeneic hematopoietic cell transplant with unrelated bone marrow. On day 20, the patient developed impaired consciousness and disorientation. Examination of the cerebrospinal fluid showed 2&times;10<sup>4</sup> copies/mL of HHV6B. HHV6 encephalitis was diagnosed, as had HHV6 myelitis based on symptoms that included lancinating pain/pruritus in the lower limbs and dysuria/dyschezia. Concurrently, he showed sinus tachycardia. Even after clearance of the HHV6 genome from the plasma and CSF was achieved by treatment with foscarnet, sinus tachycardia persisted for another 100 days. We suspected prolonged sinus tachycardia due to dysautonomia caused by HHV6 encephalomyelitis.<br>

    DOI: 10.2169/internalmedicine.51.6640

    PubMed

    CiNii Article

  • Eosinophilia, Regardless of Degree, is Related to Better Outcomes after Allogeneic Hematopoietic Stem Cell Transplantation Reviewed

    Nakane Takahiko, Nakamae Hirohisa, Hirose Asao, Nakamae Mika, Koh Hideo, Hayashi Yoshiki, Nishimoto Mitsutaka, Umemoto Yukari, Yoshimura Takuro, Bingo Masato, Okamura Hiroshi, Yoshida Masahiro, Ichihara Hiroyoshi, Aimoto Mizuki, Terada Yoshiki, Nakao Yoshitaka, Ohsawa Masahiko, Hino Masayuki

    一般社団法人 日本内科学会 INTERNAL MEDICINE   51 ( 8 )   851 - 858   2012( ISSN:0918-2918

     More details

    Publishing type:Research paper (scientific journal)  

    <b>Objective</b> Several recent studies report that, after allogeneic hematopoietic cell transplantation (allo-HCT), eosinophilia is a favorable factor for transplant outcomes. However, whether the degree of eosinophilia influences transplant outcomes is yet to be established.<br> <b>Methods</b> We studied 144 patients with hematological malignancy who received allo-HCT at our institution. The stem cell sources were bone marrow in 84 patients, peripheral blood stem cells in 32 patients, and cord blood in 28 patients. One hundred and twelve patients underwent myeloablative conditioning and 49 patients had high-risk disease. We performed semi-landmark analysis to examine the influence of eosinophilia.<br> <b>Results</b> Eosinophilia developed at a median of 47 days after transplantation in 63 patients (44%). The patients with eosinophilia showed significantly better overall survival (OS) and a lower relapse rate at three years, compared to those without eosinophilia (66% vs 55%, p=0.04 and 30% vs 50%, p=0.002). On analysis following division into groups with mild (500-1,500&times;10<sup>6</sup>/L) and hyper- (>1,500&times;10<sup>6</sup>/L) eosinophilia, three-year OS and relapse rates were 68% and 65% (p=0.92), and 31% and 28% (p=0.90), respectively. On multivariate analysis, eosinophilia was significantly associated with lower relapse rates [HR: 0.5 (95% CI: 0.3-0.9), p=0.01] and the same trend was preserved in the analysis of the mild and hyper-eosinophilic groups.<br> <b>Conclusion</b> The results suggest that eosinophilia after allo-HCT was associated with better OS and a lower relapse rate, regardless of the levels. The mechanism of this effect is still unclear, and requires study of the pathophysiological process to clarify the relationship between the higher levels of eosinophilia after allo-HCT and organ infiltration.<br>

    DOI: 10.2169/internalmedicine.51.6726

    PubMed

    CiNii Article

  • Serum Cytokine Profiles in Hemophagocytic Syndrome following Allogeneic Hematopoietic Stem Cell Transplantation Reviewed

    Koh Hideo, Nakane Takahiko, Sakamoto Erina, Katayama Takako, Nakamae Hirohisa, Ohsawa Masahiko, Hino Masayuki

    ACTA HAEMATOLOGICA   127 ( 3 )   182 - 185   2012( ISSN:0001-5792

     More details

    Authorship:Lead author   Publishing type:Research paper (scientific journal)   International / domestic magazine:International journal  

    DOI: 10.1159/000335536

    PubMed

  • Immunoglobulin Prophylaxis Against Cytomegalovirus Infection in Patients at High Risk of Infection Following Allogeneic Hematopoietic Cell Transplantation Reviewed

    Ichihara H., Nakamae H., Hirose A., Nakane T., Koh H., Hayashi Y., Nishimoto M., Nakamae M., Yoshida M., Bingo M., Okamura H., Aimoto M., Manabe M., Hagihara K., Terada Y., Nakao Y., Hino M.

    TRANSPLANTATION PROCEEDINGS   43 ( 10 )   3927 - 3932   2011.12( ISSN:0041-1345

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.transproceed.2011.08.104

  • Immunoprofile of Patients with Chronic Myeloid Leukemia Treated with Imatinib, Nilotinib or Dasatinib Reviewed

    Hayashi Yoshiki, Nakamae Hirohisa, Katayama Takako, Nakane Takahiko, Koh Hideo, Nishimoto Mitsutaka, Nakamae Mika, Yoshida Masahiro, Bingo Masato, Okamura Hiroshi, Aimoto Mizuki, Manabe Masahiro, Yoshimura Takuro, Inaba Akiko, Nanno Satoshi, Hagihara Kiyoyuki, Nakao Yoshitaka, Terada Yoshiki, Hino Masayuki

    BLOOD   118 ( 21 )   1607 - 1607   2011.11( ISSN:0006-4971

     More details

    Publishing type:Research paper (scientific journal)  

  • Risk Factors Affecting Cardiac Left Ventricular Systolic and Diastolic Function and Hypertrophy in the Chronic Phase Post-Allogeneic Hematopietic Cell Transplantation Reviewed

    Nishimoto Mitsutaka, Nakamae Hirohisa, Nakane Takahiko, Koh Hideo, Hayashi Yoshiki, Nakamae Mika, Yoshida Masahiro, Bingo Masato, Okamura Hiroshi, Aimoto Mizuki, Manabe Masahiro, Yoshimura Takuro, Inaba Akiko, Nanno Satoshi, Hirose Asao, Hagihara Kiyoyuki, Nakao Yoshitaka, Terada Yoshiki, Hino Masayuki

    BLOOD   118 ( 21 )   873 - 873   2011.11( ISSN:0006-4971

     More details

    Publishing type:Research paper (scientific journal)  

  • Immunoprofile of Patients with Chronic Myeloid Leukemia Treated with Imatinib, Nilotinib or Dasatinib Reviewed

    Hayashi Yoshiki, Nakamae Hirohisa, Katayama Takako, Nakane Takahiko, Koh Hideo, Nishimoto Mitsutaka, Nakamae Mika, Yoshida Masahiro, Bingo Masato, Okamura Hiroshi, Aimoto Mizuki, Manabe Masahiro, Yoshimura Takuro, Inaba Akiko, Nanno Satoshi, Hagihara Kiyoyuki, Nakao Yoshitaka, Terada Yoshiki, Hino Masayuki

    BLOOD   118 ( 21 )   1607 - 1607   2011.11( ISSN:0006-4971

     More details

    Publishing type:Research paper (scientific journal)  

  • Cigarette Smoking and the Association with Glomerular Hyperfiltration and Proteinuria in Healthy Middle-Aged Men Reviewed

    Maeda Isseki, Hayashi Tomoshige, Sato Kyoko Kogawa, Koh Hideo, Harita Nobuko, Nakamura Yoshiko, Endo Ginji, Kambe Hiroshi, Fukuda Kanji

    CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY   6 ( 10 )   2462 - 2469   2011.10( ISSN:1555-9041

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.2215/CJN.00700111

    PubMed

  • Membranous nephropathy with nephrotic syndrome developed after allogeneic hematopoietic stem cell transplantation for acute lymphoblastic leukemia Reviewed

    AIMOTO Mizuki, YAMANE Takahisa, ICHII Mitsuru, MORI Katsuhito, MORIGUCHI AIMOTO Ran, WADA INOUE Eri, KOH Hideo, NAKANE Takahiko, TAKEOKA Yasunobu, AKAHORI NAKAMAE Mika, NISHIKI KOSAKA Saori, TERADA Yoshiki, NAKAMAE Hirohisa, KOH Ki-Ryang, NAKAO Takafumi, OHSAWA Masahiko, WAKASA Kenichi, ISHIMURA Eiji, INABA Masaaki, HINO Masayuki

    The Japanese Society of Hematology, Rinsho Ketsueki   52 ( 7 )   556 - 562   2011.07( ISSN:04851439

     More details

    Publishing type:Research paper (scientific journal)  

    A 38-year-old man was diagnosed with acute lymphoblastic leukemia. We performed myeloablative bone marrow transplantation from an unrelated donor during the patient's first complete remission. After engraftment, he developed acute graft-versus-host disease involving the gastrointestinal tract on day 32. Steroids and mycophenolate mofetil were initiated from day 39. His symptoms improved and the dose of immunosuppressants was tapered and then discontinued on day 421. On day 491, he developed nephrotic syndrome (NS). Based on renal biopsy, membranous nephropathy was diagnosed. There were no apparent symptoms or abnormal laboratory data suggestive of chronic graft-versus-host disease (cGVHD). Steroid therapy was initiated from day 518 and proteinuria improved significantly. NS is very rare following allogeneic hematopoietic stem cell transplantation (allo-HSCT). When there is no concomitant cGVHD, as in this case, allo-HSCT-associated NS is difficult to distinguish from idiopathic NS.

    DOI: 10.11406/rinketsu.52.556

    CiNii Article

  • Visceral adiposity, not abdominal subcutaneous fat area, is associated with high blood pressure in Japanese men: the Ohtori study Reviewed International coauthorship

    Koh Hideo, Hayashi Tomoshige, Sato Kyoko Kogawa, Harita Nobuko, Maeda Isseki, Nishizawa Yoshiki, Endo Ginji, Fujimoto Wilfred Y., Boyko Edward J., Hikita Yonezo

    HYPERTENSION RESEARCH   34 ( 5 )   565 - 572   2011.05( ISSN:0916-9636

     More details

    Authorship:Lead author   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/hr.2010.271

    PubMed

  • Factors that contribute to long-term survival in patients with leukemia not in remission at allogeneic hematopoietic cell transplantation Reviewed

    Koh Hideo, Nakamae Hirohisa, Hagihara Kiyoyuki, Nakane Takahiko, Manabe Masahiro, Hayashi Yoshiki, Nishimoto Mitsutaka, Umemoto Yukari, Nakamae Mika, Hirose Asao, Inoue Eri, Inoue Atsushi, Yoshida Masahiro, Bingo Masato, Okamura Hiroshi, Aimoto Ran, Aimoto Mizuki, Terada Yoshiki, Koh Ki-Ryang, Yamane Takahisa, Ohsawa Masahiko, Hino Masayuki

    JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH   30   36   2011.04( ISSN:1756-9966

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/1756-9966-30-36

    PubMed

  • Reduced-intensity conditioning by fludarabine/busulfan without additional irradiation or T-cell depletion leads to low non-relapse mortality in unrelated bone marrow transplantation Reviewed

    Nakane Takahiko, Nakamae Hirohisa, Koh Hideo, Nakamae Mika, Hayashi Yoshiki, Nishimoto Mitsutaka, Yoshimura Takuro, Inoue Eri, Inoue Atsushi, Aimoto Ran, Aimoto Mizuki, Terada Yoshiki, Koh Ki-Ryang, Yamane Takahisa, Hino Masayuki

    INTERNATIONAL JOURNAL OF HEMATOLOGY   93 ( 4 )   509 - 516   2011.04( ISSN:0925-5710

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s12185-011-0805-z

    PubMed

  • Blood pressure components and risk for chronic kidney disease in middle-aged Japanese men: The Kansai Healthcare Study Reviewed

    Koh Hideo, Hayashi Tomoshige, Sato Kyoko Kogawa, Harita Nobuko, Maeda Isseki, Nakamura Yoshiko, Endo Ginji, Kambe Hiroshi, Fukuda Kanji

    HYPERTENSION RESEARCH   34 ( 4 )   536 - 541   2011.04( ISSN:0916-9636

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/hr.2011.2

    PubMed

  • Elevated White Blood Cell Count Worsens Proteinuria but Not Estimated Glomerular Filtration Rate: The Kansai Healthcare Study Reviewed

    Sato Kyoko Kogawa, Hayashi Tomoshige, Harita Nobuko, Koh Hideo, Maeda Isseki, Endo Ginji, Nakamura Yoshiko, Kambe Hiroshi, Fukuda Kanji

    AMERICAN JOURNAL OF NEPHROLOGY   34 ( 4 )   324 - 329   2011( ISSN:0250-8095

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.1159/000330845

    PubMed

  • Factors That Contribute to Long-Term Survival In Patients with Leukemia Not In Remission at Allogeneic Hematopoietic Cell Transplantation Reviewed

    Koh Hideo, Nakamae Hirohisa, Nakane Takahiko, Manabe Masahiro, Hayashi Yoshiki, Nishimoto Mitsutaka, Umemoto Kaori, Nakamae Mika, Hirose Asao, Inoue Eri, Inoue Atsushi, Yoshida Masahiro, Bingo Masato, Okamura Hiroshi, Aimoto Ran, Aimoto Mizuki, Terada Yoshiki, Koh Ki-Ryang, Yamane Takahisa, Hino Masayuki

    BLOOD   116 ( 21 )   1460 - 1460   2010.11( ISSN:0006-4971

     More details

    Publishing type:Research paper (scientific journal)  

  • 同種造血幹細胞移植後のリポソーマルアムホテリシンB投与中に新規発症したトリコスポロン血症の一例 Reviewed

    康 秀男, 井上 恵里, 中根 孝彦, 武岡 康信, 相本 蘭, 相本 瑞樹, 寺田 芳樹, 中前 博久, 高 起良, 山根 孝久, 大澤 政彦, 日野 雅之

    (株)医薬ジャーナル社 血液フロンティア   20 ( 12 )   2176 - 2179   2010.11( ISSN:1344-6940

     More details

    Publishing type:Research paper (scientific journal)  

    63歳女。骨髄異形成症候群からの急性骨髄性白血病と診断され、化学療法で寛解後に非血縁骨髄移植を施行したが骨髄再発した。再寛解導入療法を施行し、第2寛解後に再度非血縁骨髄移植を施行した。day28に好中球生着を確認したが、day32以降にアデノウイルスによる出血性膀胱炎およびウイルス血症、サイトメガロウイルス抗原血症、腎出血を発症し、ribavirin、gancyclovir、血小板輸血などを使用した。day83にCRP高値が続き、liposomal amphoptericin B(L-AMB)を5mg/kg/dayに変更した。いったん改善したが、day104より発熱が出現し、β-Dグルカン著明上昇を認め、静脈血液培養で酵母様真菌が検出され、後日Trichosporon spp.と判明した。day108よりvoriconazole 400mg/dayとmicafungin 300mg/dayの点滴に変更したところ、翌日には解熱し、β-Dグルカンも減少し、血液培養陰性を確認した。しかし、day 122より再び発熱し、翌日Stenotrophomonas maltophilia敗血症で死亡した。

  • 同種骨髄移植後の内臓播種性水痘帯状疱疹ウイルス感染症に合併した血球貪食症候群の診断に血清フェリチンが有用であった1例 Reviewed

    宮本 奈津子, 康 秀男, 中根 孝彦, 和田 恵里, 相本 瑞樹, 相本 蘭, 武岡 康信, 寺田 芳樹, 中前 博久, 高 起良, 山根 孝久, 大澤 政彦, 日野 雅之

    (株)診断と治療社 診断と治療   98 ( 9 )   1539 - 1542   2010.09( ISSN:0370-999X

     More details

    Publishing type:Research paper (scientific journal)  

    24歳女。急性骨髄性白血病にて骨髄移植を受けたが再発し、再移植目的で入院となった。同種増血幹細胞移植を受け寛解状態であったが、下剤抵抗性の便秘、上腹部痛が出現し、更には汎血球減少、肝逸脱酵素の上昇、フェリチン高値を認めた。骨髄検査を行ったが、血球貪食像は認めなかった。その後、全身に散在性の水疱が出現したためアシクロビル投与を開始したが、翌日に血球減少の進行、肝逸脱酵素、フェリチンの急激な上昇を認めた。高熱なく、診断基準を十分に満たしていなかったが血球貪食症候群と診断し、メチルプレドニゾロンを追加したところ、翌日より肝機能、フェリチン値ともに改善を認めた。後日、皮疹の生検で巨細胞を認め、VZV-DNA高値であり、内臓播種性水痘帯状疱疹ウイルス感染症と確定診断した。ウイルス量は次第に減少し、難治性であった腹痛も改善して退院となった。

  • 進行期白血病に対する静注Busulfan(Busulfex)+Cyclophosphamide+Total Lymphoid Irradiationを用いたModified Myeloablative Conditioningによる同種造血幹細胞移植 Reviewed

    中前 博久, 寺田 芳樹, 中根 孝彦, 康 秀男, 中前 美佳, 相本 蘭, 廣瀬 朝生, 林 良樹, 西本 光孝, 井上 恵里, 吉村 卓朗, 井上 敦司, 高 起良, 山根 孝久, 日野 雅之

    (株)癌と化学療法社 癌と化学療法   37 ( 9 )   1691 - 1695   2010.09( ISSN:0385-0684

     More details

    Publishing type:Research paper (scientific journal)  

    同種造血幹細胞移植の移植前処置の強度の最適化を検討する目的で静注busulfan 8mg/kg+cyclophosphamide 120mg/kg+total lymphoid irradiation(TLI)7.5Gyによるmodified myeloablative conditioning regimenにて進行期の急性、慢性白血病9例に対して同種造血幹細胞移植を行った。年齢の中央値は30(18〜59)歳。造血幹細胞源は血縁骨髄2例、血縁末梢血幹細胞1例、非血縁骨髄6例。急性graft-versus-host disease(GVHD)予防はcyclosporin+短期methotrexate療法で行った。急性GVHDは9人中6例(67%)に出現し、全例でgrade 2であった。広範型慢性GVHDは評価可能症例7例中3例に認められた。移植後観察期間中央値は813(248〜1702)日で、9例中5例で移植後に原疾患の再発、再燃を認めたが、移植後100日以内の再発例はなかった。移植全観察期間を通じて移植関連死亡は認めなかった。2年の全生存率は88.9%、無病生存率は50.0%であった。今回の結果から骨髄破壊的前処置を最適化することによって、移植関連死亡を減少させると同時に病勢をコントロールし得る至適な移植前処置が存在する可能性があると考えられた。(著者抄録)

  • Heart rate variability during and after peripheral blood stem cell leukapheresis in autologous transplant patients and allogeneic transplant donors Reviewed

    Nakane Takahiko, Nakamae Hirohisa, Koh Hideo, Nakamae Mika, Aimoto Ran, Terada Yoshiki, Koh Ki-Ryang, Yamane Takahisa, Hino Masayuki

    INTERNATIONAL JOURNAL OF HEMATOLOGY   91 ( 3 )   478 - 484   2010.04( ISSN:0925-5710

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s12185-010-0543-7

    PubMed

  • Serum Cytokine Profiles at the Onset of Severe, Diffuse Alveolar Hemorrhage Complicating Allogeneic Hematopoietic Stem Cell Transplantation, Treated Successfully with Pulse Intravenous Cyclophosphamide Reviewed

    Koh Hideo, Nakamae Hirohisa, Koh Ki-Ryang, Ohsawa Masahiko, Nakane Takahiko, Takeoka Yasunobu, Aimoto Ran, Aimoto Mizuki, Wada-Inoue Eri, Terada Yoshiki, Yamane Takahisa, Hino Masayuki

    ACTA HAEMATOLOGICA   124 ( 3 )   171 - 175   2010( ISSN:0001-5792

     More details

    Authorship:Lead author   Publishing type:Research paper (scientific journal)   International / domestic magazine:International journal  

    DOI: 10.1159/000318013

    PubMed

  • Epstein-Barr virus-associated post-transplant lymphoproliferative disorder diagnosed by the episode of intestinal perforation following allogeneic hematopoietic stem cell transplantation Reviewed

    AIMOTO Mizuki, TAKEOKA Yasunobu, AKAHORI-NAKAMAE Mika, NISHIKI-KOSAKA Saori, TERADA Yoshiki, NAKAMAE Hirohisa, KOH Ki-Ryang, NAKAO Takafumi, OHSAWA Masahiko, HINO Masayuki, YAMANE Takahisa, INOUE Atushi, MOMOSE Dai, MORIGUCHI-AIMOTO Ran, WADA-INOUE Eri, OKAMOTO Syuuichirou, KOH Hideo, NAKANE Takahiko

    The Japanese Society of Hematology, Rinsho Ketsueki   51 ( 12 )   1775 - 1780   2010( ISSN:0485-1439

     More details

    Publishing type:Research paper (scientific journal)  

    A 64-year-old man was diagnosed as having acute myeloid leukemia. We performed sequential treatment with chemotherapy and reduced-intensity stem cell transplantation from an unrelated donor while the patient was in partial remission. After engraftment, he developed acute graft-versus-host disease of the gut on day 42 and steroid therapy was started. Despite transient aggravation of diarrhea, his symptoms slowly improved and the dose of steroid was tapered. On day 159, he complained of acute left lower abdominal pain. A CT scan showed perforation of the digestive tract and ileectomy was performed. At surgery, multiple ulcers of the intestine were found and one of the ulcers was perforated. Pathologically, transmural and diffuse proliferation of atypical cells in the ulcer were confirmed. Since these cells were positive for CD20 and Epstein-Barr-virus (EBV) encoded RNA, we made a diagnosis of EBV-associated post-transplant lymphoproliferative disorder (PTLD). Reduction in the dose of immunosuppressive agents and rituximab led to complete remission of PTLD. PTLD after allogeneic hematopoietic stem cell transplantation (allo-HSCT) is relatively rare, and the development of gastrointestinal perforation after allo-HSCT is very rare.

    DOI: 10.11406/rinketsu.51.1775

    CiNii Article

  • Impact of relative dose intensity (RDI) in CHOP combined with rituximab (R-CHOP) on survival in diffuse large B-cell lymphoma Reviewed

    Terada Yoshiki, Nakamae Hirohisa, Aimoto Ran, Kanashima Hiroshi, Sakamoto Erina, Aimoto Mizuki, Inoue Eri, Koh Hideo, Nakane Takahiko, Takeoka Yasunobu, Ohsawa Masahiko, Koh Ki-Ryang, Yamane Takahisa, Nakao Yoshitaka, Ohta Kensuke, Mugitani Atsuko, Teshima Hirofumi, Hino Masayuki

    JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH   28   116   2009.08( ISSN:1756-9966

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/1756-9966-28-116

    PubMed

  • Efficacy and safety of intravenous itraconazole as empirical antifungal therapy for persistent fever in neutropenic patients with hematological malignancies in Japan Reviewed

    Ohta Kensuke, Kosaka Saori Nishiki, Nakao Yoshitaka, Kumura Takeo, Hagihara Kiyomichi, Sakamoto Erina, Okamoto Shuichiro, Hirose Asao, Aoyama Yasutaka, Yamamura Ryousuke, Hayashi Yoshiki, Umemoto Yukari, Terada Yoshiki, Takeoka Yasunobu, Nakane Takahiko, Koh Hideo, Hino Masayuki

    INTERNATIONAL JOURNAL OF HEMATOLOGY   89 ( 5 )   649 - 655   2009.06( ISSN:0925-5710

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s12185-009-0316-3

    PubMed

  • Prognostic value of serum surfactant protein D level prior to transplant for the development of bronchiolitis obliterans syndrome and idiopathic pneumonia syndrome following allogeneic hematopoietic stem cell transplantation Reviewed

    Nakane T., Nakamae H., Kamoi H., Koh H., Takeoka Y., Sakamoto E., Kanashima H., Nakamae M., Ohta K., Terada Y., Koh K-R, Yamane T., Hino M.

    BONE MARROW TRANSPLANTATION   42 ( 1 )   43 - 49   2008.07( ISSN:0268-3369

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/bmt.2008.73

  • Possible involvement of gamma delta-t cells in the development of chronic graft-versus-host disease after allogeneic hematopoietic stem cell transplantation Reviewed

    Koh Ki-Ryang, Nakamae Hirohisa, Ohta Kensuke, Li Hongzhang, Koh Hideo, Nakane Takahiko, Takeoka Yasunobu, Hirose Asao, Hagihara Kiyoyuki, Sakamoto Erina, Nakamae Mika, Terada Yoshiki, Yamane Takahisa, Hino Masayuki

    BLOOD   110 ( 11 )   586A - 587A   2007.11( ISSN:0006-4971

     More details

    Publishing type:Research paper (scientific journal)  

  • The impact of relative dose intensity (RDI) of CHOP on outcome of diffuse large B-cell lymphoma: Results of a single center study Reviewed

    Terada Yoshiki, Nakamae Hirohisa, Nakane Takahiko, Koh Hideo, Takeoka Yasunobu, Moriguchi Ran, Aimoto Mizuki, Akazawa Yuki, Wada Eri, Kanashima Hiroshi, Sakamoto Erma, Koh Ki-Ryang, Yamane Takahisa, Ohta Kensuke, Nakao Yoshitaka, Teshima Hirofumi, Hino Masayuki

    BLOOD   110 ( 11 )   184B - 184B   2007.11( ISSN:0006-4971

     More details

    Publishing type:Research paper (scientific journal)  

  • Improved outcome in brain abscess during induction in acute myelocytic leukemia.

    Nakane T, Yamane T, Nakamae H, Ichihara H, Koh H, Takeoka Y, et al.

    34   789 - 92   2007.05

     More details

    Publishing type:Research paper (scientific journal)  

  • Allogeneic hematopoietic stem cell transplantation for adult T cell leukemia: Result of a single center study Reviewed

    Koh Hideo H., Koh Ki-Ryang K., Hagihara Kiyoyuki K., Nakane Takahiko K., Takeoka Yasunobu K., Kanashima Hiroshi K., Sakamoto Erina K., Nakamae Mika K., Ichihara Hiroyoshi K., Terada Yoshiki K., Nakamae Hirohisa K., Ohta Kensuke K., Yamane Takahisa K., Watanabe Toshiki K., Hino Masayuki K.

    AIDS RESEARCH AND HUMAN RETROVIRUSES   23 ( 4 )   604 - 605   2007.04( ISSN:0889-2229

     More details

    Publishing type:Research paper (scientific journal)  

  • Two cases of ampulla (takotsubo-shaped) cardiomyopathy associated with hemophagocytic lymphohistiocytosis Reviewed

    Takeoka Yasunobu, Nakamae Mika, Nakamae Hirohisa, Hagihara Kiyoyuki, Sakamoto Erina, Nakane Takahiko, Koh Hideo, Koh Ki-Ryang, Ohta Kensuke, Yamane Takahisa, Hino Masayuki

    ACTA HAEMATOLOGICA   117 ( 4 )   205 - 210   2007( ISSN:0001-5792

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.1159/000098461

    PubMed

  • Myelodysplastic syndrome with cyclosporine A-induced encephalopathy presenting with a mass effect on the right basal ganglia after cord blood transplantation Reviewed

    KOH Hideo, YAMANE Takahisa, NAKANE Takahiko, TAKEOKA Yasunobu, SAKAMOTO Erina, KANASHIMA Hiroshi, NAKAMAE Mika, NAKAMAE Hirohisa, KOH Ki-ryang, MOCHIZUKI Kunizo, HAYASHI Noriko, HINO Masayuki

    The Japanese Society of Hematology, Rinsho Ketsueki   47 ( 12 )   1539 - 1543   2006.12( ISSN:04851439

     More details

    Publishing type:Research paper (scientific journal)  

    An 18-year-old female with myelodysplastic syndrome underwent an allogeneic cord blood transplantation in May 2005. The conditioning regimen consisted of total body irradiation, cytarabine and cyclophosphamide. The day of the cord stem cell transfusion was counted as Day 0. For acute GVHD prophylaxis, cyclosporine A (CsA) and methotrexate were used. Engraftment was achieved on Day 30, acute GVHD grade II developed on Day 45 and treatment with methylprednisolone for acute GVHD was started. On Day 68 the patient had generalized seizures accompanied by loss of consciousness, hypertension and left hemiparesis, and was intubated. A cranial CT scan showed a mass effect on the right basal ganglia, and high signal intensities on the T2-weighted and FLAIR images of a MR examination were detected in the bilateral basal ganglia and posterior lobes, the findings of which were compatible with a brain tumor or infectious disease. Since an increased level of apparent diffusion coefficient (ADC) values on the bilateral basal ganglia was noted, we suspected that vasogenic edema had caused the mass effect. She went into remission immediately after CsA treatment was discontinued. Therefore, this case was diagnosed as atypical reversible posterior leukoencephalopathy syndrome (RPLS) associated with CsA. CsA-induced encephalopathy presenting a mass effect in clinical imaging findings is very rare, and an ADC map may be useful for the diagnosis of RPLS.

    DOI: 10.11406/rinketsu.47.1539

    CiNii Article

  • Decreased serum levels of surfactant protein D (SP-D) prior transplant is associated with the development of bronchiolitis obliterans (BO) and idiopathic pneumonia syndrome (IPS) following allogeneic hematopoietic stem cell transplantation. Reviewed

    Nakane Takahiko, Nakamae Hirohisa, Kamoi Hiroshi, Koh Hideo, Takeoka Yasunobu, Sakamoto Erina, Kanashima Hiroshi, Ichihara Hiroyoshi, Nakamae Mika, Koh Ki-Ryang, Yamane Takahisa, Hino Masayuki

    BLOOD   108 ( 11 )   825A - 825A   2006.11( ISSN:0006-4971

     More details

    Publishing type:Research paper (scientific journal)  

  • Preferential Th2 polarization at the onset of thrombotic microangiopathy (TMA): Immunological comparison of TMA versus acute GVHD in terms of peripheral T cell subsets, dendritic cell subsets and cytokine profiles. Reviewed

    Koh Ki-Ryang, Nakamae Hirohisa, Ohta Kensuke, Koh Hideo, Nakane Takahiko, Nakamae Mika, Kanashima Hiroshi, Hagihara Kiyoyuki, Sakamoto Erma, Terada Yoshiki, Takeoka Yasunobu, Hirose Asao, Yamane Takahisa, Hino Masayuki

    BLOOD   108 ( 11 )   817A - 817A   2006.11( ISSN:0006-4971

     More details

    Publishing type:Research paper (scientific journal)  

  • Non-TBI, Non-ATG containing fludarabine-based regimen for unrelated allogeneic reduced intensity transplantation. Reviewed

    Nakamae Hirohisa, Nakane Takahiko, Koh Hideo, Takaoka Yasunobu, Sakamoto Erina, Kanashima Hiroshi, Ichihara Hiroyoshi, Nakamae Mika, Koh Ki-Ryang, Yamane Takahisa, Hino Masayuki

    BLOOD   108 ( 11 )   439B - 439B   2006.11( ISSN:0006-4971

     More details

    Publishing type:Research paper (scientific journal)  

  • High-dose chemotherapy with autologous hematopoietic stem cell transplantation for non-Hodgkin's lymphoma in complete response as consolidation therapy, second report.

    Yamane T, Hirose A, Nakajima Y, Nakane T, Koh H, Takeoka Y, et al.

    33   193 - 8   2006.02

     More details

    Publishing type:Research paper (scientific journal)  

▼display all

Books and Other Publications

  • 発熱性好中球減少症(FN)診療ガイドライン改訂第3版

    日本臨床腫瘍学会編集( Role: Contributor)

    南江堂  2024.02  ( ISBN:978-4-524-23376-2

     More details

    Total pages:124  

  • VII. 支持療法・輸血 4. ムーコル感染症の診断と治療

    金倉譲/監修 木崎昌弘/編集 鈴木律朗, 神田善伸, 他( Role: Contributor)

    中外医学社・EBM血液疾患の治療 2021-2022  2021.01 

     More details

    Total pages:637   Responsible for pages:516-523  

  • 同種造血幹細胞移植ポケットマニュアル (第3版改訂)

    大阪市立大学医学部附属病院 血液内科・造血細胞移植科( Role: Contributor)

    大阪市立大学医学部附属病院 血液内科・造血細胞移植科  2019.03 

  • 抗真菌薬の予防投与の意義

    金倉 譲  編集( Role: Contributor)

    中外医学社・EBM血液疾患の治療2017-2018  2016.10 

     More details

    Total pages:542   Responsible for pages:452-459  

  • 同種造血幹細胞移植ポケットマニュアル (第2版改訂)

    大阪市立大学医学部附属病院 血液内科・造血細胞移植科( Role: Contributor)

    大阪市立大学医学部附属病院 血液内科・造血細胞移植科  2014.10 

MISC

  • 赤白血病におけるマスター転写因子のドライバー変異 International journal

    康 秀男, 日野 雅之

    科学評論社・血液内科   82 ( 5 )   704 - 710   2021.05

     More details

    Publishing type:Article, review, commentary, editorial, etc. (scientific journal)   Kind of work:Joint Work   International / domestic magazine:Domestic journal  

  • 急性骨髄性白血病のエピゲノムを標的とした治療

    康 秀男, 星居 孝之, 日野 雅之

    (有)科学評論社 血液内科   81 ( 1 )   93 - 100   2020.07( ISSN:2185-582X

     More details

    Publishing type:Article, review, commentary, editorial, etc. (scientific journal)   Kind of work:Joint Work  

  • Waldenstroemマクログロブリン血症細胞の起源と進展

    康 秀男, 日野 雅之

    (有)科学評論社 血液内科   71 ( 6 )   781 - 786   2015.12( ISSN:2185-582X

     More details

    Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • HLA Haplo-Identical Peripheral Blood Stem Cell Transplantation Using High-Dose Cyclophosphamide Post-Transplantation For Poor Prognosis Or Refractory Acute Leukemia and Myelodysplastic Syndrome: A Prospective Pilot Study At a Single Center

    Hirohisa Nakamae, Hideo Koh, Mitsutaka Nishimoto, Yasuhiro Nakashima, Satoru Nanno, Takuro Yoshimura, Shiro Koh, Hiroshi Okamura, Jyoji Nagasaki, Takahiko Nakane, Mika Nakamae, Asao Hirose, Masayuki Hino

    BLOOD   122 ( 21 )   2013.11( ISSN:0006-4971 ( eISSN:1528-0020

     More details

    Publishing type:Research paper, summary (international conference)  

  • 【血液疾患診療のためのガイドライン〜発熱性好中球減少症ならびに造血細胞移植後早期の感染管理〜】発熱性好中球減少症時の抗真菌薬使用の実際 特にカスポファンギンについて

    康 秀男

    (株)医薬ジャーナル社 血液フロンティア   22 ( 12 )   1891 - 1898   2012.11( ISSN:1344-6940

     More details

    Publishing type:Article, review, commentary, editorial, etc. (scientific journal)   Kind of work:Single Work  

    抗菌薬不応性の発熱性好中球減少症に対する抗真菌薬の経験的治療は標準的治療法であるが、実際の真菌感染症は半数にも満たず、多くの不必要な投与が行われるため、薬剤の有効性に加えて安全性も重要である。カスポファンギンはキャンディン系抗真菌薬としては本邦で初めて、発熱性好中球減少症に対して保険承認を獲得し、有効性・安全性の強力なエビデンスからも、第一選択薬として使用しやすい。また、抗アスペルギルス作用を有し、近年増加しているアスペルギルス症に対しても治療選択肢の一つになり得る。本稿では自験例を中心に、投与の実際について概説する。(著者抄録)

Presentations

▼display all

Grant-in-Aid for Scientific Research

  • 分子量毎のメタロミクス解析による新規生活習慣病発症危険因子の網羅的検討

    Grant-in-Aid for Challenging Research (Pioneering)/(Exploratory)  2023.06

  • PTCyによる造血細胞移植の国際標準化に向けて:抗腫瘍効果を効果的に誘導するには?

    Grant-in-Aid for Scientific Research(C)  2023.04

  • 血液疾患コホートを利用した治療標的分子探索および数理モデリングによる病態解析

    Grant-in-Aid for Scientific Research(C)  2020.04

  • Identification of genotypes in immune-related genes predicting outcomes in patients following allogeneic hematopoietic cell transplantation

    Grant-in-Aid for Early-Career Scientists  2018.04

  • 難治性白血病に対する同種造血幹細胞移植後の再発と感染症発症抑制に関する研究

    Grant-in-Aid for Young Scientists(B)  2012.04

Incentive donations / subsidies

  • 2018年医学系研究助成がん領域(臨床)

    武田科学振興財団  2018

Other subsidies, etc.

  • アルブミンの劣化 に主眼をおいたアルツハイマー病発症前診断及びその治療応用に関する研究

    厚生労働科学研究費補助金   疾病・障害対策研究分野 【委託費】 認知症研究開発  2014.04

Charge of on-campus class subject

  • 医学研究推進コース3(医学部3年生)

    2023     Undergraduate

  • 産業医学2(医学部4年生)

    2023     Undergraduate

  • 産業医学1(医学部3年生)

    2023     Undergraduate

  • 医学英語論文の読み方(医学部2年生)

    2023     Undergraduate

Social Activities

  • 造血細胞移植看護基礎研修会Ⅰ

    Role(s): Lecturer

    2021.11

  • 造血細胞移植看護基礎研修会Ⅰ

    Role(s): Lecturer

    大阪市立大学医学部附属病院  2020.10

     More details

    Type:Seminar, workshop

  • 造血幹細胞移植推進拠点病院セミナー

    Role(s): Lecturer

    大阪市立大学医学部附属病院  2016.08

     More details

    Type:Seminar, workshop

  • 造血幹細胞移植推進拠点病院セミナー

    Role(s): Lecturer

    大阪市立大学医学部附属病院  2016.01

     More details

    Type:Seminar, workshop

  • 造血幹細胞移植推進拠点病院セミナー

    Role(s): Lecturer

    大阪市立大学医学部附属病院  2015.07

     More details

    Type:Seminar, workshop

  • 造血幹細胞移植推進拠点病院セミナー

    Role(s): Lecturer

    大阪市立大学医学部附属病院  2014.10

     More details

    Type:Seminar, workshop

  • 若手医師のための同種造血幹細胞移植集中セミナー

    Role(s): Lecturer

    グランフロント大阪   2014.03

     More details

    Type:Seminar, workshop

▼display all

Other

  • Job Career

    2011