Updated on 2024/04/24

写真a

 
KAI Masatake
 
Organization
Graduate School of Medicine Department of Basic Medical Science Lecturer
School of Medicine Department of Medical Science
Title
Lecturer
Affiliation
Institute of Medicine

Position

  • Graduate School of Medicine Department of Basic Medical Science 

    Lecturer  2022.04 - Now

  • School of Medicine Department of Medical Science 

    Lecturer  2022.04 - Now

Degree

  • Doctor of Science (Ph. D.) ( The University of Tokyo )

Research Areas

  • Life Science / Developmental biology

  • Life Science / Developmental biology

Research Career

  • Study of molecular mechanisms underlying co-ordinated cell migration during early development

    cell migration, morphogenesis, molecular signalling 

    2002.02 - Now 

Professional Memberships

  • 日本発生生物学会

      Domestic

  • 日本解剖学会

      Domestic

  • 日本解剖学会

  • 日本発生生物学会

Job Career (off-campus)

  • Osaka City University   Graduate School of Medicine Basic Medicine Course

    2012.04 - Now

  • 自然科学研究機構・基礎生物学研究所   形態形成研究部門   研究員

    2009.04 - 2011.03

  • 自然科学研究機構・基礎生物学研究所   形態形成研究部門

    2009.04 - 2011.03

  • University College London   Department of Anatomy and Developmental Biology   Research Fellow

    2002.02 - 2009.04

  • University College London   Department of Anatomy and Developmental Biology   Research Fellow

    2002.02 - 2009.04

  • 国立国際医療センター研究所   感染・熱帯病研究部   流動研究員

    2001.04 - 2002.01

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Education

  • The University of Tokyo   Department of Biological Sciences   Doctor's Course   Graduated/Completed

    - 2001

  • The University of Tokyo   Department of Biology     Graduated/Completed

    - 1996

Papers

  • A novel case of multiple variations in the brachial plexus with the middle trunk originating from the C7 and C8. Reviewed

    Kimura S, Amatani H, Nakai H, Miyauchi R, Nagaoka T, Abe M, Kai M, Yamagishi T, Nakajima Y

    Anatomical science international   95 ( 4 )   559 - 563   2020.09( ISSN:1447-6959

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s12565-020-00541-3

    PubMed

  • A novel case of multiple variations in the brachial plexus with the middle trunk originating from the C7 and C8(和訳中) Reviewed

    Kimura Seiichi, Amatani Hiromu, Nakai Hikaru, Miyauchi Ren, Nagaoka Tomohito, Abe Mikiko, Kai Masatake, Yamagishi Toshiyuki, Nakajima Yuji

    シュプリンガー・ジャパン(株) Anatomical Science International   95 ( 4 )   559 - 563   2020.09( ISSN:1447-6959

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    Publishing type:Research paper (scientific journal)  

  • Phosphorylation-dependent ubiquitination of paraxial protocadherin (PAPC) controls gastrulation cell movements. Reviewed

    Kai M, Ueno N, Kinoshita N

    PloS one   10 ( 1 )   e0115111   2015

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1371/journal.pone.0115111

    PubMed

  • Epicardium is required for sarcomeric maturation and cardiomyocyte growth in the ventricular compact layer mediated by transforming growth factor β and fibroblast growth factor before the onset of coronary circulation:Epicardium and compact myocardium growth Reviewed

    Takahashi Makiko, Yamagishi Toshiyuki, Narematsu Mayu, Kamimura Tatsuya, Kai Masatake, Nakajima Yuji

    Wiley   54 ( 3 )   162 - 171   2014.08( ISSN:0914-3505

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    Publishing type:Research paper (scientific journal)  

    CiNii Article

  • Epicardium is required for sarcomeric maturation and cardiomyocyte growth in the ventricular compact layer mediated by transforming growth factor beta and fibroblast growth factor before the onset of coronary circulation Reviewed

    Takahashi Makiko, Yamagishi Toshiyuki, Narematsu Mayu, Kamimura Tatsuya, Kai Masatake, Nakajima Yuji

    CONGENITAL ANOMALIES   54 ( 3 )   162 - 171   2014.08( ISSN:0914-3505

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/cga.12048

    PubMed

  • 冠動脈血行の開始以前において心外膜はトランスホーミング増殖因子-βと線維芽細胞増殖因子を介した心室緻密層におけるサルコメア成熟と心筋細胞増殖に必要である(Epicardium is required for sarcomeric maturation and cardiomyocyte growth in the ventricular compact layer mediated by transforming growth factor β and fibroblast growth factor before the onset of coronary circulation) Reviewed

    Takahashi Makiko, Yamagishi Toshiyuki, Narematsu Mayu, Kamimura Tatsuya, Kai Masatake, Nakajima Yuji

    John Wiley & Sons Australia, Ltd Congenital Anomalies   54 ( 3 )   162 - 171   2014.08( ISSN:0914-3505

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    Publishing type:Research paper (scientific journal)  

  • Myocardial progenitors in the pharyngeal regions migrate to distinct conotruncal regions Reviewed

    Takahashi Makiko, Terasako Yumi, Yanagawa Nariaki, Kai Masatake, Yamagishi Toshiyuki, Nakajima Yuji

    DEVELOPMENTAL DYNAMICS   241 ( 2 )   284 - 293   2012.02( ISSN:1058-8388

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/dvdy.23714

    PubMed

  • Planar Cell Polarity in Coordinated and Directed Movements Reviewed

    Tada Masazumi, Kai Masatake

    PLANAR CELL POLARITY DURING DEVELOPMENT   101   77 - 110   2012( ISBN:978-0-12-394592-1

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/B978-0-12-394592-1.00004-1

    PubMed

  • Epicardial TGFb Signal Is Required for Myocardial Maturation Before the Onset of Coronary Circulation. Reviewed

    Takahashi M., Yanagawa N., Kai M., Yamagishi T., Nakajima Y.

    MOLECULAR BIOLOGY OF THE CELL   22   2011( ISSN:1059-1524

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    Publishing type:Research paper (scientific journal)  

  • Bbs8, together with the planar cell polarity protein Vangl2, is required to establish left-right asymmetry in zebrafish. Reviewed

    May-Simera HL, Kai M, Hernandez V, Osborn DP, Tada M, Beales PL

    Developmental biology   345 ( 2 )   215 - 25   2010.09( ISSN:0012-1606

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.ydbio.2010.07.013

    PubMed

  • Noncanonical Wnt/PCP signaling during vertebrate gastrulation. Reviewed

    Tada M, Kai M

    Zebrafish   6 ( 1 )   29 - 40   2009.03( ISSN:1545-8547

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1089/zeb.2008.0566

    PubMed

  • Sphingosine-1-phosphate receptors regulate individual cell behaviours underlying the directed migration of prechordal plate progenitor cells during zebrafish gastrulation. Reviewed

    Kai M, Heisenberg CP, Tada M

    Development (Cambridge, England)   135 ( 18 )   3043 - 51   2008.09( ISSN:0950-1991

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1242/dev.020396

    PubMed

  • IFT80, which encodes a conserved intraflagellar transport protein, is mutated in Jeune asphyxiating thoracic dystrophy. Reviewed

    Beales PL, Bland E, Tobin JL, Bacchelli C, Tuysuz B, Hill J, Rix S, Pearson CG, Kai M, Hartley J, Johnson C, Irving M, Elcioglu N, Winey M, Tada M, Scambler PJ

    Nature genetics   39 ( 6 )   727 - 9   2007.06( ISSN:1061-4036

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/ng2038

    PubMed

  • Disruption of Bardet-Biedl syndrome ciliary proteins perturbs planar cell polarity in vertebrates. Reviewed

    Ross AJ, May-Simera H, Eichers ER, Kai M, Hill J, Jagger DJ, Leitch CC, Chapple JP, Munro PM, Fisher S, Tan PL, Phillips HM, Leroux MR, Henderson DJ, Murdoch JN, Copp AJ, Eliot MM, Lupski JR, Kemp DT, Dollfus H, Tada M, Katsanis N, Forge A, Beales PL

    Nature genetics   37 ( 10 )   1135 - 40   2005.10( ISSN:1061-4036

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/ng1644

    PubMed

  • [Cellular and molecular mechanisms underlying vertebrate gastrulation]. Reviewed

    Kai M, Tada M

    Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme   50 ( 6 Suppl )   608 - 14   2005.05( ISSN:0039-9450

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    Publishing type:Research paper (scientific journal)  

    PubMed

  • Involvement of caspase-9 in execution of the maternal program of apoptosis in Xenopus late blastulae overexpressed with S-adenosylmethionine decarboxylase. Reviewed

    Takayama E, Higo T, Kai M, Fukasawa M, Nakajima K, Hara H, Tadakuma T, Igarashi K, Yaoita Y, Shiokawa K

    Biochemical and biophysical research communications   325 ( 4 )   1367 - 75   2004.12( ISSN:0006-291X

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.bbrc.2004.10.179

    PubMed

  • Characterization of a trinucleotide repeat sequence (CGG)5 and potential use in restriction fragment length polymorphism typing of Mycobacterium tuberculosis. Reviewed

    Otsuka Y, Parniewski P, Zwolska Z, Kai M, Fujino T, Kirikae F, Toyota E, Kudo K, Kuratsuji T, Kirikae T

    Journal of clinical microbiology   42 ( 8 )   3538 - 48   2004.08( ISSN:0095-1137

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1128/JCM.42.8.3538-3548.2004

    PubMed

  • Overexpression of S-adenosylmethionine decarboxylase (SAMDC) in Xenopus embryos activates maternal program of apoptosis as a "fail-safe" mechanism of early embryogenesis. Reviewed

    Kai M, Kaito C, Fukamachi H, Higo T, Takayama E, Hara H, Ohya Y, Igarashi K, Shiokawa K

    Cell research   13 ( 3 )   147 - 58   2003.06( ISSN:1001-0602

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/sj.cr.7290159

    PubMed

  • Activation of the maternally preset program of apoptosis by microinjection of 5-aza-2'-deoxycytidine and 5-methyl-2'-deoxycytidine-5'-triphosphate in Xenopus laevis embryos. Reviewed

    Kaito C, Kai M, Higo T, Takayama E, Fukamachi H, Sekimizu K, Shiokawa K

    Development, growth & differentiation   43 ( 4 )   383 - 90   2001.08( ISSN:0012-1592

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1046/j.1440-169x.2001.00579.x

    PubMed

  • Overexpression of S-adenosylmethionine decarboxylase (SAMDC) activates the maternal program of apoptosis shortly after MBT in Xenopus embryos. Reviewed

    Kai M, Higo T, Yokoska J, Kaito C, Kajita E, Fukamachi H, Takayama E, Igarashi K, Shiokawa K

    The International journal of developmental biology   44 ( 5 )   507 - 10   2000.08( ISSN:0214-6282

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    Publishing type:Research paper (scientific journal)  

    PubMed

  • Maternal program of apoptosis activated shortly after midblastula transition by overexpression of S-adenosylmethionine decarboxylase in Xenopus early embryos. Reviewed

    Shiokawa K, Kai M, Higo T, Kaito C, Yokoska J, Yasuhiko Y, Kajita E, Nagano M, Yamada Y, Shibata M, Muto T, Shinga J, Hara H, Takayama E, Fukamachi H, Yaoita Y, Igarashi K

    Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology   126 ( 2 )   149 - 55   2000.06( ISSN:1096-4959

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/s0305-0491(00)00193-0

    PubMed

  • [Transcription in Xenopus early embryos and apoptotic program preset in the fertilized egg]. Reviewed

    Shiokawa K, Kai M, Higo T, Fukamachi H, Takayama E

    Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme   44 ( 1 )   32 - 41   1999.01( ISSN:0039-9450

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    Publishing type:Research paper (scientific journal)  

    PubMed

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Presentations

Grant-in-Aid for Scientific Research

  • ゼブラフィッシュ胚心臓における刺激伝導系細胞の可視化とその発生過程の発現情報収集

    Grant-in-Aid for Scientific Research(C)  2024

Charge of on-campus class subject

  • 医学推進研究コース1

    2023     Undergraduate

  • 臨床病態学

    2023     Graduate school

  • 生体構造機能学

    2023     Graduate school

  • 医科学概論

    2023     Graduate school

  • 医学研究推進コース3

    2023     Undergraduate

  • 初年次ゼミナール

    2023     Undergraduate

  • 発生学

    2023     Undergraduate

  • 肉眼解剖(マクロ)実習

    2023     Undergraduate

  • 神経解剖

    2023     Undergraduate

  • 感覚器・皮膚

    2023     Undergraduate

  • 運動器系

    2023     Undergraduate

  • 循環器系

    2023     Undergraduate

  • 修業実習

    2019     Undergraduate

  • 基礎医学研究推進コース

    2019     Undergraduate

  • 肉眼解剖学(マクロ)実習

    2019     Undergraduate

  • 消化器系コース

    2019     Undergraduate

  • 免疫系コース

    2019     Undergraduate

  • 呼吸器系コース

    2019     Undergraduate

  • 循環器系コース

    2019     Undergraduate

  • 運動器系コース

    2019     Undergraduate

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Charge of off-campus class subject

  • 理学療法学基礎演習

  • 解剖生理学

  • 理学療法学基礎演習

  • 解剖生理学

Faculty development activities

  • FD講習会受講  2023

Visiting Lectures ⇒ Link to the list of Visiting Lectures

  • 生物の形をつくる細胞の振舞い

    Category:Modern system science (knowledge information system, environmental system, educational welfare, psychology), Commerce (management, public management), Economics, Law (law, politics, administration), Literature (literature, philosophy, history, art, human behavior, language, culture, society / gender), Science (mathematics, physics, chemistry, biology, geology, biochemistry), Engineering (machinery, electronics / physics, electrical / electronics, electrical information, chemical biotechnology, architecture, cities (civil engineering / environment), material chemistry, aerospace, marine systems, applied chemistry, chemistry, materials), Life sciences (food, nutrition science, living environment, human welfare), Agricultural science (applied biology, biofunctional chemistry, green space environmental science), Medicine (medical care, rehabilitation, health exercise science, physical fitness / training, sports practice science), Nursing (nursing, sex education), Veterinary

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    Audience:General

    1つの受精卵から生物の形がつくられる過程には,統合された細胞の運動が必須な役割を果たしている。そのような細胞の振舞いをとらえるための技術や,運動の分子機構に関する研究について,最新の知見を紹介する。
    生物が基本的な形をつくっていくメカニズムについて,最新の知見を紹介する。