Updated on 2024/04/12

写真a

 
ENOMOTO Masaru
 
Organization
Graduate School of Medicine Department of Clinical Medical Science Associate Professor
School of Medicine Department of Medical Science
Title
Associate Professor
Affiliation
Institute of Medicine

Position

  • Graduate School of Medicine Department of Clinical Medical Science 

    Associate Professor  2010.04 - Now

  • School of Medicine Department of Medical Science 

    Associate Professor  2010.04 - Now

Degree

  • 医学博士 ( Osaka City University )

Research Areas

  • Life Science / General internal medicine

  • Life Science / Gastroenterology

Research Career

  • ウイルス性肝炎の診断と治療

    B型肝炎、C型肝炎  International Joint Research

  • 肝胆膵がんの診断と治療

Professional Memberships

  • THE JANPANESE SOCIETY OF INTERNAL MEDICINE

      Domestic

  • 日本肝臓学会 肝臓専門医・指導医

      Domestic

  • 日本消化器病学会 消化器病専門医・指導医

      Domestic

  • 日本消化器内視鏡学会 専門医

      Domestic

  • 日本輸血・細胞治療学会 認定医、自己血輸血責任医師

      Domestic

  • 日本感染症学会 インフェクションコントロールドクター

      Domestic

  • 日本がん治療認定医機構 がん治療認定医

  • 日本臨床栄養学会 認定臨床栄養医

      Domestic

  • 日本膵臓学会

      Domestic

  • 日本超音波医学会

      Domestic

  • American Association for the Study of Liver Diseases

      Overseas

  • 日本アルコール・アディクション医学会

      Domestic

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Committee Memberships (off-campus)

  • 生活保護法医療扶助業務担当非常勤嘱託職員   大阪市  

    2024.04 - 2025.03 

  • 学術評議員   日本アルコール・アディクション医学会  

    2023.02 - Now 

  • 肝臓専門医制度審議会委員   日本肝臓学会  

    2022.10 - Now 

  • 評議員   日本臨床栄養学会  

    2022.10 - Now 

  • 肝炎治療医療費援助事業及び肝がん・重度肝硬変治療研究促進事業認定協議会   大阪府  

    2022.04 - Now 

  • 欧文誌編集委員会委員   日本肝臓学会  

    2020.10 - Now 

  • Associate Editor   Cancers (Basel)  

    2020 - Now 

  • Associate Editor   Hepatology Research (The Official Journal of the Japan Society of Hepatology)  

    2020 - Now 

  • 学会評議員   日本肝臓学会  

    2016 - Now 

  • 国民健康保険診療報酬審査委員会委員   大阪府  

    2013.04 - 2015.03 

  • 近畿支部評議員   日本内科学会  

    2013 - Now 

  • 総会・大会評議員   日本消化器病学会  

    2011 - Now 

  • 近畿支部評議員   日本消化器内視鏡学会  

    2008 - Now 

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Awards

  • Travel Award at the Biennial Meeting of IASL

    2000  

  • 大阪市医学会市長賞

    2001  

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    Country:Japan

  • 上原記念生命科学財団海外留学助成リサーチフェローシップ

    2004  

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    Country:Japan

  • ウイルス肝炎研究財団研究奨励金

    2010  

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    Country:Japan

  • 日本肝臓学会研究奨励賞

    2011  

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    Country:Japan

  • 大阪市立大学医学部長賞奨励賞

    2019  

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    Country:Japan

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Job Career (off-campus)

  • University of Texas Medical Branch

    2004 - 2005

Education

  • Osaka City University   Doctor's Course   Graduated/Completed

    - 1999

  • Osaka City University     Graduated/Completed

    - 1993

Papers

  • Characteristics of patients with hepatitis C virus with and without GB virus C/hepatitis G virus co-infection and efficacy of interferon alfa.

    Hepatology   27 ( 5 )   1388 - 93   1998

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    Publishing type:Research paper (scientific journal)  

  • Hepatitis B surface antigen glycan isomer is a predictor of the development of hepatocellular carcinoma during nucleoside/nucleotide analog therapy.

    Kozuka R, Enomoto M, Yukawa-Muto Y, Odagiri N, Kotani K, Motoyama H, Kawamura E, Hagihara A, Fujii H, Uchida-Kobayashi S, Kawada N

    Hepatology research : the official journal of the Japan Society of Hepatology   2024.02( ISSN:1386-6346

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  • Pretreatment gamma-glutamyl transferase predicts mortality in patients with chronic hepatitis B treated with nucleotide/nucleoside analogs.

    Jang TY, Liang PC, Jun DW, Jung JH, Toyoda H, Wang CW, Yuen MF, Cheung KS, Yasuda S, Kim SE, Yoon EL, An J, Enomoto M, Kozuka R, Chuma M, Nozaki A, Ishikawa T, Watanabe T, Atsukawa M, Arai T, Hayama K, Ishigami M, Cho YK, Ogawa E, Kim HS, Shim JJ, Uojima H, Jeong SW, Ahn SB, Takaguchi K, Senoh T, Buti M, Vargas-Accarino E, Abe H, Takahashi H, Inoue K, Huang JF, Chuang WL, Yeh ML, Dai CY, Huang CF, Nguyen MH, Yu ML

    The Kaohsiung journal of medical sciences   40 ( 2 )   188 - 197   2024.02( ISSN:1607-551X

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  • C-CAT's triumph in gastroenterology: the wisdom of cats is infinitely superior.

    Enomoto M, Odagiri N, Rinka K, Maruyama H, Shimamoto Y, Ishikawa-Kakiya Y, Fujiwara Y, Kawada N, Yashiro M

    Journal of gastroenterology   59 ( 2 )   157 - 158   2024.02( ISSN:0944-1174

  • Racial and ethnic disparities in untreated patients with hepatitis C virus-related hepatocellular carcinoma but not in those with sustained virologic response.

    Park JE, Nguyen VH, Tsai PC, Toyoda H, Leong J, Guy JE, Yeh ML, Huang CF, Yasuda S, Abe H, Hsu YC, Tseng CH, Liu J, Chen YL, Lin PY, Jun DW, Yoshimaru Y, Ogawa E, Ishigami M, Enomoto M, Tamori A, Uojima H, Wang XZ, Xu Q, Takahashi H, Eguchi Y, Inoue K, Huang DQ, Zhao WJ, Chuang WL, Dai CY, Huang JF, Barnett S, Maeda M, Cheung R, Landis C, Tanaka Y, Roberts LR, Schwartz ME, Kumada T, Yu ML, Nguyen MH

    Alimentary pharmacology & therapeutics   2024.01( ISSN:0269-2813

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  • Increased spine bone density in patients with chronic hepatitis B switched to tenofovir alafenamide: A prospective, multinational study.

    Ogawa E, Jun DW, Toyoda H, Hsu YC, Yoon EL, Ahn SB, Yeh ML, Do S, Trinh HN, Takahashi H, Enomoto M, Kawada N, Yasuda S, Tseng CH, Kawashima K, Lee HA, Inoue K, Haga H, Do AT, Maeda M, Hoang JH, Cheung R, Ueno Y, Eguchi Y, Furusyo N, Yu ML, Tanaka Y, Nguyen MH

    Alimentary pharmacology & therapeutics   59 ( 2 )   239 - 248   2024.01( ISSN:0269-2813

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  • Characterization of circulating miRNAs in the treatment of primary liver tumors.

    Umezu T, Tanaka S, Kubo S, Enomoto M, Tamori A, Ochiya T, Taguchi YH, Kuroda M, Murakami Y

    Cancer reports (Hoboken, N.J.)   e1964   2023.12

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  • Collaborating with AI in literature search-An important frontier.

    Enomoto M, Tseng CH, Hsu YC, Thuy LTT, Nguyen MH

    Hepatology communications   7 ( 12 )   2023.12

  • 拠点病院以外の肝疾患専門医療機関における院内肝炎ウイルス陽性者対策調査

    井上 泰輔, 井出 達也, 内田 義人, 小川 浩司, 井上 貴子, 末次 淳, 池上 正, 瀬戸山 博子, 井上 淳, 柿崎 暁, 榎本 大, 立木 佐知子, 遠藤 美月, 永田 賢治, 是永 匡紹

    肝臓   64 ( 12 )   649 - 652   2023.12( ISSN:0451-4203

  • 肝炎ウイルス陽性者対策が急がれる非肝臓専門科は?

    廣田 健一, 井上 貴子, 小川 浩司, 荒生 祥尚, 遠藤 美月, 池上 正, 戸島 洋貴, 末次 淳, 柿崎 暁, 瀬戸山 博子, 榎本 大, 是永 匡紹

    肝臓   64 ( 11 )   587 - 589   2023.11( ISSN:0451-4203

  • 肝疾患診療連携拠点病院における肝炎医療コーディネーターの現状(第2報)

    磯田 広史, 榎本 大, 高橋 宏和, 大野 高嗣, 井上 泰輔, 池上 正, 井出 達也, 徳本 良雄, 小川 浩司, 瀬戸山 博子, 内田 義人, 橋本 まさみ, 廣田 健一, 柿崎 暁, 立木 佐知子, 井上 貴子, 遠藤 美月, 島上 哲朗, 荒生 祥尚, 井上 淳, 末次 淳, 永田 賢治, 是永 匡紹

    肝臓   64 ( 10 )   510 - 513   2023.10( ISSN:0451-4203

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    全国の肝疾患診療連携拠点病院21施設において2021年度現在勤務している肝炎医療コーディネーター(肝Co)の、人数(現職数)、実働率、職種、配属部署等についてアンケート調査を行った。21施設において肝Coは合計951名が養成され、現職数は714名(75.1%)であった。実働率は全体で83.6%であり、9施設が100%と回答したが、31.7%の施設もあった。肝Coの職種は看護師が最も多く(49%)、次いで臨床検査技師(11%)、薬剤師(10%)、管理栄養士(7%)の順であった。21施設中、前回調査(2019年度)にも参加した17施設の実働率平均は85.8%で、前回調査(84.2%)と比べてわずかに上昇しており、コロナ禍においても肝Co活動は維持されていると考えられた。

  • Real-world treatment outcome with protease inhibitor direct-acting antiviral in advanced hepatitis C cirrhosis: a REAL-C study.

    Wong YJ, Tran S, Huang CF, Hsu YC, Preda C, Toyoda H, Liu J, Jun DW, Landis C, Huang DQ, Gila A, Negoita L, Yasuda S, Tseng CH, Tsai PC, Uojima H, Nozaki A, Chuma M, Atsukawa M, Ishigami M, Itokawa N, Iio E, Lam CP, Watanabe T, Asai A, Yokohama K, Abe H, Enomoto M, Kawada N, Tamori A, Lee DH, Jun MJ, Do S, Vo DKH, Liu L, Li J, Ji F, Wang W, Li Y, Wang X, Guo F, Xu Q, Jing L, Ye Q, Pan H, Zhang J, Wen X, Wang Q, Ren H, Cai D, Shang J, Liu J, Lu C, Zang W, Li J, Niu J, Zhang M, Wu C, Huang R, Maeda M, Nakanishi A, Yeh ML, Chuang WL, Huang JF, Dai C, Ishikawa T, Takaguchi K, Senoh T, Trinh HN, Takahashi H, Eguchi Y, Quek SXZ, Haga H, Ogawa E, Wong G, Buti M, Fukunishi S, Ueno Y, Yuen MF, Tanaka Y, Lim SG, Cheung R, Yu ML, Nguyen MH

    Hepatology international   17 ( 5 )   1150 - 1161   2023.10( ISSN:1936-0533

  • Hepatocellular organellar abnormalities following elimination of hepatitis C virus.

    Aoyagi H, Iijima H, Gaber ES, Zaitsu T, Matsuda M, Wakae K, Watashi K, Suzuki R, Masaki T, Kahn J, Saito T, El-Kassas M, Shimada N, Kato K, Enomoto M, Hayashi K, Tsubota A, Mimata A, Sakamaki Y, Ichinose S, Muramatsu M, Wake K, Wakita T, Aizaki H

    Liver international : official journal of the International Association for the Study of the Liver   43 ( 8 )   1677 - 1690   2023.08( ISSN:1478-3223

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  • Editorial: risk of renal function decline in patients with chronic hepatitis B virus infection treated with nucleos(t)ide analogues.

    Kozuka R, Enomoto M, Kawada N

    Alimentary pharmacology & therapeutics   58 ( 1 )   124 - 125   2023.07( ISSN:0269-2813

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  • Global treatment rate and barriers to direct-acting antiviral therapy: A systematic review and meta-analysis of 146 studies and 1 760 352 hepatitis C virus patients.

    Nguyen VH, Huang DQ, Le MH, Jin M, Lee EY, Henry L, Nerurkar SN, Ogawa E, Thin KN, Teng MLP, Goh KS, Kai JCY, Wong C, Tan DJH, Thuy LTT, Hai H, Enomoto M, Cheung R, Nguyen MH

    Liver international : official journal of the International Association for the Study of the Liver   43 ( 6 )   1195 - 1203   2023.06( ISSN:1478-3223

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  • Antiviral therapy substantially reduces hepatocellular carcinoma risk in chronic Hepatitis B patients in the indeterminate phase.

    Huang DQ, Tran A, Yeh ML, Yasuda S, Tsai PC, Huang CF, Dai CY, Ogawa E, Ishigami M, Ito T, Kozuka R, Enomoto M, Suzuki T, Yoshimaru Y, Preda CM, Marin RI, Sandra I, Tran S, Quek SX, Khine HHTW, Itokawa N, Atsukawa M, Uojima H, Watanabe T, Takahashi H, Inoue K, Maeda M, Hoang JK, Trinh L, Barnett S, Cheung R, Lim SG, Trinh HN, Chuang WL, Tanaka Y, Toyoda H, Yu ML, Nguyen MH

    Hepatology (Baltimore, Md.)   2023.05( ISSN:0270-9139

  • Risk factors for liver-related and non-liver-related mortality following a sustained virological response after direct-acting antiviral treatment for hepatitis C virus infection in a real-world cohort.

    Kozuka R, Tamori A, Enomoto M, Muto-Yukawa Y, Odagiri N, Kotani K, Motoyama H, Kawamura E, Hagihara A, Fujii H, Uchida-Kobayashi S, Kawada N

    Journal of viral hepatitis   30 ( 5 )   374 - 385   2023.05( ISSN:1352-0504

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  • Short-term hepatocyte function and portal hypertension outcomes of sofosbuvir/velpatasvir for decompensated hepatitis C-related cirrhosis.

    Kotani K, Enomoto M, Uchida-Kobayashi S, Tamori A, Yukawa-Muto Y, Odagiri N, Motoyama H, Kozuka R, Kawamura E, Hagihara A, Fujii H, Kageyama K, Yamamoto A, Yoshida A, Higashiyama S, Kawabe J, Kawada N

    Journal of gastroenterology   58 ( 4 )   394 - 404   2023.04( ISSN:0944-1174

  • Severity of Liver Fibrosis Is Associated with the Japanese Diet Pattern and Skeletal Muscle Mass in Patients with Nonalcoholic Fatty Liver Disease.

    Matsumoto Y, Fujii H, Harima M, Okamura H, Yukawa-Muto Y, Odagiri N, Motoyama H, Kotani K, Kozuka R, Kawamura E, Hagihara A, Uchida-Kobayashi S, Enomoto M, Yasui Y, Habu D, Kawada N

    Nutrients   15 ( 5 )   2023.02

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  • A case of hepatocellular carcinoma with "pseudoprogression" followed by complete response to atezolizumab plus bevacizumab.

    Odagiri N, Tamori A, Kotani K, Motoyama H, Kawamura E, Hagihara A, Fujii H, Uchida-Kobayashi S, Enomoto M, Kawada N

    Clinical journal of gastroenterology   2023.02( ISSN:18657257

  • Influence of a biliary stent in patients with advanced pancreatic cancer treated with modified FOLFIRINOX.

    Yoshikawa-Kimura A, Taira K, Maruyama H, Ishikawa-Kakiya Y, Yamamura M, Tanoue K, Hagihara A, Uchida-Kobayashi S, Enomoto M, Kimura K, Tanaka S, Amano R, Takemura S, Ohfuji S, Tanaka F, Nagami Y, Fujiwara Y

    Medicine   101 ( 49 )   e32150   2022.12( ISSN:0025-7974

  • Suppression of intrahepatic cholangiocarcinoma cell growth by SKI via upregulation of the CDK inhibitor p21.

    Kawamura E, Matsubara T, Daikoku A, Deguchi S, Kinoshita M, Yuasa H, Urushima H, Odagiri N, Motoyama H, Kotani K, Kozuka R, Hagihara A, Fujii H, Uchida-Kobayashi S, Tanaka S, Takemura S, Iwaisako K, Enomoto M, Taguchi YH, Tamori A, Kubo S, Ikeda K, Kawada N

    FEBS open bio   12 ( 12 )   2122 - 2135   2022.12

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  • Effectiveness of entecavir vs tenofovir disoproxil fumarate for functional cure of chronic hepatitis B in an international cohort.

    Hsu YC, Jun DW, Peng CY, Yeh ML, Trinh H, Wong GL, Kim SE, Chen CH, Oh H, Lin CH, Trinh L, Wong VW, Yoon E, Ahn SB, Huang D, Cho YK, Jeong JY, Jeong SW, Kim HS, Xie Q, Liu L, Riveiro-Barciela M, Tsai PC, Accarino EV, Toyoda H, Enomoto M, Preda C, Marciano S, Hoang J, Huang CF, Kozuka R, Yasuda S, Istratescu D, Lee DH, Su JY, Huang YT, Huang JF, Dai CY, Chuang WL, Yuen MF, Gadano A, Cheung R, Lim SG, Buti M, Yu ML, Nguyen MH

    Hepatology international   16 ( 6 )   1297 - 1307   2022.12( ISSN:1936-0533

  • Efficacy of rechallenge transcatheter arterial chemoembolization after lenvatinib treatment for advanced hepatocellular carcinoma.

    Uchida-Kobayashi S, Kageyama K, Takemura S, Matsumoto K, Odagiri N, Jogo A, Kotani K, Kozuka R, Motoyama H, Kawamura E, Hagihara A, Yamamoto A, Fujii H, Tanaka S, Enomoto M, Tamori A, Miki Y, Kubo S, Kawada N

    JGH open : an open access journal of gastroenterology and hepatology   6 ( 11 )   754 - 762   2022.11

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  • Soluble Immune Checkpoint Protein CD27 Is a Novel Prognostic Biomarker of Hepatocellular Carcinoma Development in Hepatitis C Virus-Sustained Virological Response Patients.

    Dong MP, Thuy LTT, Hoang DV, Hai H, Hoang TH, Sato-Matsubara M, Hieu VN, Daikoku A, Hanh NV, Urushima H, Dat NQ, Uchida-Kobayashi S, Enomoto M, Ohtani N, Tamori A, Kawada N

    The American journal of pathology   192 ( 10 )   1379 - 1396   2022.10( ISSN:0002-9440

  • Cancer cells produce liver metastasis via gap formation in sinusoidal endothelial cells through proinflammatory paracrine mechanisms.

    Huu Hoang T, Sato-Matsubara M, Yuasa H, Matsubara T, Thuy LTT, Ikenaga H, Phuong DM, Hanh NV, Hieu VN, Hoang DV, Hai H, Okina Y, Enomoto M, Tamori A, Daikoku A, Urushima H, Ikeda K, Dat NQ, Yasui Y, Shinkawa H, Kubo S, Yamagishi R, Ohtani N, Yoshizato K, Gracia-Sancho J, Kawada N

    Science advances   8 ( 39 )   eabo5525   2022.09

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  • Progression Rates by Age, Sex, Treatment, and Disease Activity by AASLD and EASL Criteria: Data for Precision Medicine.

    Park J, Le AK, Tseng TC, Yeh ML, Jun DW, Trinh H, Wong GLH, Chen CH, Peng CY, Kim SE, Oh H, Kwak MS, Cheung KS, Toyoda H, Hsu YC, Jeong JY, Yoon EL, Ungtrakul T, Zhang J, Xie Q, Ahn SB, Enomoto M, Shim JJ, Cunningham C, Jeong SW, Cho YK, Ogawa E, Huang R, Lee DH, Takahashi H, Tsai PC, Huang CF, Dai CY, Tseng CH, Yasuda S, Kozuka R, Li J, Wong C, Wong CC, Zhao C, Hoang J, Eguchi Y, Wu C, Tanaka Y, Gane E, Tanwandee T, Cheung R, Yuen MF, Lee HS, Yu ML, Kao JH, Yang HI, Nguyen MH

    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association   20 ( 4 )   874 - 885.e4   2022.04( ISSN:1542-3565

  • Longitudinal renal changes in chronic hepatitis B patients treated with entecavir versus TDF: a REAL-B study.

    Mak LY, Hoang J, Jun DW, Chen CH, Peng CY, Yeh ML, Kim SE, Huang DQ, Jeong JY, Yoon E, Oh H, Tsai PC, Huang CF, Ahn SB, Trinh H, Xie Q, Wong GLH, Enomoto M, Shim JJ, Lee DH, Liu L, Kozuka R, Cho YK, Jeong SW, Kim HS, Trinh L, Dao A, Huang R, Hui RW, Tsui V, Quek S, Khine HHTW, Ogawa E, Dai CY, Huang JF, Cheung R, Wu C, Chuang WL, Lim SG, Yu ML, Yuen MF, Nguyen MH

    Hepatology international   16 ( 1 )   48 - 58   2022.02( ISSN:1936-0533

  • Soluble programmed cell death-1 predicts hepatocellular carcinoma development during nucleoside analogue treatment.

    Kozuka R, Enomoto M, Dong MP, Hai H, Thuy LTT, Odagiri N, Yoshida K, Kotani K, Motoyama H, Kawamura E, Hagihara A, Fujii H, Uchida-Kobayashi S, Tamori A, Kawada N

    Scientific reports   12 ( 1 )   105   2022.01

  • On-treatment gamma-glutamyl transferase predicts the development of hepatocellular carcinoma in chronic hepatitis B patients.

    Huang CF, Jang TY, Jun DW, Ahn SB, An J, Enomoto M, Takahashi H, Ogawa E, Yoon E, Jeong SW, Shim JJ, Jeong JY, Kim SE, Oh H, Kim HS, Cho YK, Kozuka R, Inoue K, Cheung KS, Mak LY, Huang JF, Dai CY, Yuen MF, Nguyen MH, Yu ML

    Liver international : official journal of the International Association for the Study of the Liver   42 ( 1 )   59 - 68   2022.01( ISSN:1478-3223

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  • Direct-acting antivirals reduce the risk of tumour progression of hepatocellular carcinoma after curative treatment.

    Ikenaga H, Uchida-Kobayashi S, Tamori A, Odagiri N, Yoshida K, Kotani K, Motoyama H, Kozuka R, Kawamura E, Hagihara A, Fujii H, Enomoto M, Kawada N

    Journal of viral hepatitis   29 ( 1 )   52 - 59   2022.01( ISSN:1352-0504

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  • Serum miR-192-5p levels predict the efficacy of pegylated interferon therapy for chronic hepatitis B.

    Nagura Y, Matsuura K, Iio E, Fujita K, Inoue T, Matsumoto A, Tanaka E, Nishiguchi S, Kang JH, Matsui T, Enomoto M, Ikeda H, Watanabe T, Okuse C, Tsuge M, Atsukawa M, Tateyama M, Kataoka H, Tanaka Y

    PloS one   17 ( 2 )   e0263844   2022

  • Switching from entecavir to tenofovir disoproxil fumarate for HBeAg-positive chronic hepatitis B patients: a phase 4, prospective study.

    Suzuki F, Suzuki Y, Karino Y, Tanaka Y, Kurosaki M, Yatsuhashi H, Atarashi T, Atsukawa M, Watanabe T, Enomoto M, Kudo M, Maeda N, Kohno H, Joko K, Michitaka K, Miki K, Takahashi K, Ide T, Fujiyama S, Kohno T, Itoh H, Tsukamoto S, Suzuki Y, Kawano Y, Sugiura W, Kumada H

    BMC gastroenterology   21 ( 1 )   489   2021.12

  • Incidences and Determinants of Functional Cure During Entecavir or Tenofovir Disoproxil Fumarate for Chronic Hepatitis B.

    Hsu YC, Yeh ML, Wong GL, Chen CH, Peng CY, Buti M, Enomoto M, Xie Q, Trinh H, Preda C, Liu L, Cheung KS, Yeo YH, Hoang J, Huang CF, Riveiro-Barciela M, Kozuka R, Istratescu D, Tsai PC, Accarino EV, Lee DH, Wu JL, Huang JF, Dai CY, Cheung R, Chuang WL, Yuen MF, Wong VW, Yu ML, Nguyen MH

    The Journal of infectious diseases   224 ( 11 )   1890 - 1899   2021.12( ISSN:0022-1899

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  • I shall be released (from infinite HBV nucleos(t)ide analog therapy): Japanese experience.

    Enomoto M, Umemura T, Suzuki F

    Journal of hepatology   75 ( 6 )   1496 - 1497   2021.12( ISSN:0168-8278

  • Sofosbuvir/Velpatasvir Plus Ribavirin Combination Therapy for Patients with Hepatitis C Virus Genotype 1a, 2a, or 3b after Glecaprevir/Pibrentasvir Therapy Failed

    Nonomura Ayami, Tamori Akihiro, Hai Hoang, Kozuka Ritsuzo, Fujii Hideki, Uchida-Kobayashi Sawako, Enomoto Masaru, Kawada Norifumi

    Internal Medicine   60 ( 21 )   3441 - 3445   2021.11( ISSN:0918-2918

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    <p>Glecaprevir/pibrentasvir (GLE/PIB) is a pan-genotype anti-hepatitis C virus (HCV) therapy with high efficacy and safety. However, evidence supporting retreatment following failure of the GLE/PIB regimen is limited. We herein report 3 non-cirrhotic cases involving two men aged 51 and 58 years old and a woman aged 68 years old infected with HCV genotype 1a, 2a, and 3b respectively who failed anti-HCV therapies including GLE/PIB therapy. With combination therapy of sofosbuvir/velpatasvir plus ribavirin (SOF/VEL+RBV) for 24 weeks, all 3 patients had achieved a sustained viral response (SVR) at 24 weeks after completing treatment. SOF/VEL+RBV therapy was effective for retreatment of HCV after failure of GLE/PIB therapy. </p>

    DOI: 10.2169/internalmedicine.7028-21

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  • Successful Transcatheter Arterial Embolization for Hemothorax from a Spontaneous Rupture of Hepatocellular Carcinoma Metastasis to the Chest Wall in an Elderly Patient

    Suoh Maito, Hagihara Atsushi, Kageyama Ken, Yamamoto Akira, Enomoto Masaru, Tamori Akihiro, Kawada Norifumi

    Internal Medicine   60 ( 14 )   2223 - 2228   2021.07( ISSN:0918-2918

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    <p>An 87-year-old man with hepatocellular carcinoma (HCC) presented with right-sided chest pain. Computed tomography revealed right bloody pleural effusion and an extravasation from an arterially enhanced mass in the right seventh posterior intercostal space. These findings indicated hemothorax from a rupture of HCC metastasis to the chest wall. Angiography of the intercostal arteries confirmed a hypervascular tumor, and transcatheter arterial embolization resulted in hemostasis. He was discharged with palliative care and remains alive after 9 months. Although hemothorax represents an unusual, life-threatening complication of HCC, our case suggests that transcatheter treatment can achieve hemostasis and a favorable survival even in elderly patients. </p>

    DOI: 10.2169/internalmedicine.6003-20

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  • The FibroScan-aspartate aminotransferase score can stratify the disease severity in a Japanese cohort with fatty liver diseases.

    Fujii H, Fukumoto S, Enomoto M, Uchida-Kobayashi S, Kimura T, Tamori A, Nadatani Y, Takashima S, Nishimoto N, Kawada N

    Scientific reports   11 ( 1 )   13844   2021.07

  • Validation of a two-step approach combining serum biomarkers and liver stiffness measurement to predict advanced fibrosis.

    Fujii H, Enomoto M, Fukumoto S, Kimura T, Nadatani Y, Takashima S, Hagihara A, Uchida-Kobayashi S, Tamori A, Nishimoto N, Kawada N

    JGH open : an open access journal of gastroenterology and hepatology   5 ( 7 )   801 - 808   2021.07

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  • Per-rectal portal scintigraphy as an alternative measure of hepatic venous pressure gradient in chronic liver disease: A preliminary report.

    Kotani K, Uchida-Kobayashi S, Yamamoto A, Kawamura E, Enomoto M, Higashiyama S, Kawabe J, Shiomi S, Tamori A, Kawada N

    Clinical physiology and functional imaging   41 ( 4 )   334 - 341   2021.07( ISSN:1475-0961

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  • Anti-fibrotic treatments for chronic liver diseases: The present and the future.

    Odagiri N, Matsubara T, Sato-Matsubara M, Fujii H, Enomoto M, Kawada N

    Clinical and molecular hepatology   27 ( 3 )   413 - 424   2021.07( ISSN:2287-2728

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  • Outcomes of Sequential Therapy With Tenofovir Alafenamide After Long-term Entecavir.

    Nguyen MH, Atsukawa M, Ishikawa T, Yasuda S, Yokohama K, Trinh HN, Arai T, Fukunishi S, Ogawa E, Hsu YC, Maeda M, Dang H, Tseng CH, Takahashi H, Jun DW, Watanabe T, Chuma M, Nozaki A, Kawada N, Cheung R, Enomoto M, Takaguchi K, Toyoda H

    The American journal of gastroenterology   116 ( 6 )   1264 - 1273   2021.06( ISSN:0002-9270

  • Utility of minimally invasive measurement of hepatic venous pressure gradient via the peripheral antecubital vein.

    Yamamoto A, Kawada N, Jogo A, Murai K, Kotani K, Kageyama K, Hamamoto S, Sohgawa E, Uchida-Kobayashi S, Enomoto M, Tamori A, Miki Y

    Gut   70 ( 6 )   1199 - 1201   2021.06( ISSN:0017-5749

  • Outcome of nucleos(t)ide analog intervention in patients with preventive or on-demand therapy for hepatitis B virus reactivation.

    Tamori A, Kimura K, Kioka K, Enomoto H, Odagiri N, Kozuka R, Uchida-Kobayashi S, Enomoto M, Kawada N, Mizokami M

    Journal of medical virology   93 ( 6 )   3679 - 3687   2021.06( ISSN:0146-6615

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  • Per-rectal portal scintigraphy as an alternative measure of hepatic venous pressure gradient in chronic liver disease: a preliminary report. Reviewed

    Kotani K, Uchida-Kobayashi S, Yamamoto A, Kawamura E, Enomoto M, Higashiyama S, Kawabe J, Shiomi S, Tamori A, Kawada N

    Clinical physiology and functional imaging   2021.04( ISSN:1475-0961

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    DOI: 10.1111/cpf.12703

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  • Lenvatinib-Induced Tumor-Related Hemorrhage in Patients With Unresectable Hepatocellular Carcinoma.

    Kotani K, Uchida-Kobayashi S, Yoshida K, Kawamura E, Fujii H, Hagihara A, Enomoto M, Tamori A, Kawada N

    The American journal of gastroenterology   116 ( 4 )   631   2021.04( ISSN:0002-9270

  • Obstructive Jaundice Due to Duodenal Ulcer Induced by Lenvatinib Therapy for Hepatocellular Carcinoma

    Suoh Maito, Hagihara Atsushi, Yamamura Masafumi, Maruyama Hirotsugu, Taira Koichi, Enomoto Masaru, Tamori Akihiro, Fujiwara Yasuhiro, Kawada Norifumi

    Internal Medicine   60 ( 4 )   545 - 552   2021.02( ISSN:0918-2918

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    <p>An 82-year-old man with hepatocellular carcinoma presented with upper abdominal pain, vomiting, and jaundice. He had been taking a standard lenvatinib dose for three months. Although acute cholangitis was suggested, imaging studies failed to detect the biliary obstruction site. An endoscopic examination following discontinuation of lenvatinib and aspirin revealed multiple duodenal ulcers, one of which was formed on the ampulla of Vater and causing cholestasis. Endoscopic biliary drainage and antibiotics improved concomitant <i>Enterobacter cloacae</i> bacteremia. Ulcer healing was confirmed after rabeprazole was replaced with vonoprazan and misoprostol. Our case shows that lenvatinib can induce duodenal ulcers resulting in obstructive jaundice. </p>

    DOI: 10.2169/internalmedicine.5097-20

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  • Combination of Entecavir or Tenofovir with Pegylated Interferon-α for Long-Term Reduction in Hepatitis B Surface Antigen Levels: Simultaneous, Sequential, or Add-on Combination Therapy.

    Yoshida K, Enomoto M, Tamori A, Nishiguchi S, Kawada N

    International journal of molecular sciences   22 ( 3 )   1 - 14   2021.02( ISSN:16616596

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  • Combination of Entecavir or Tenofovir with Pegylated Interferon-alpha for Long-Term Reduction in Hepatitis B Surface Antigen Levels: Simultaneous, Sequential, or Add-on Combination Therapy Reviewed

    Yoshida Kanako, Enomoto Masaru, Tamori Akihiro, Nishiguchi Shuhei, Kawada Norifumi

    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES   22 ( 3 )   2021.02

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    DOI: 10.3390/ijms22031456

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  • Transition rates to cirrhosis and liver cancer by age, gender, disease and treatment status in Asian chronic hepatitis B patients Reviewed

    Liu Matt, Tseng Tai-Chung, Jun Dae Won, Yeh Ming-Lun, Huy Trinh, Wong Grace L. H., Chen Chien-Hung, Peng Cheng-Yuan, Kim Sung Eun, Oh Hyunwoo, Kwak Min-Sun, Cheung Michael, Toyoda Hidenori, Hsu Yao-Chun, Jeong Jae Yoon, Yoon Eileen L., Ungtrakul Teerapat, Zhang Jian, Xie Qing, Ahn Sang Bong, Enomoto Masaru, Shim Jae-Jun, Cunningham Chris, Jeong Soung Won, Cho Yong Kyun, Ogawa Eiichi, Huang Rui, Lee Dong-Hyun, Takahashi Hirokazu, Tsai Pei-Chien, Huang Chung-Feng, Dai Chia-Yen, Tseng Cheng-Hao, Yasuda Satoshi, Kozuka Ritsuzo, Li Jiayi, Wong Christopher, Wong Clifford C., Zhao Changqing, Hoang Joseph, Eguchi Yuichiro, Wu Chao, Tanaka Yasuhito, Gane Ed, Tanwandee Tawesak, Cheung Ramsey, Yuen Man-Fung, Lee Hyo-Suk, Yu Ming-Lung, Kao Jia-Horng, Yang Hwai- I, Nguyen Mindie H.

    HEPATOLOGY INTERNATIONAL   15 ( 1 )   71 - 81   2021.02( ISSN:1936-0533

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    DOI: 10.1007/s12072-020-10113-2

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  • Lenvatinib-Induced Tumor-Related Hemorrhages in Patients with Large Hepatocellular Carcinomas Reviewed

    Uchida-Kobayashi Sawako, Kageyama Ken, Yamamoto Akira, Ikenaga Hiroko, Yoshida Kanako, Kotani Kohei, Kimura Kenjiro, Odagiri Naoshi, Hagihara Atsushi, Fujii Hideki, Enomoto Masaru, Tamori Akihiro, Kubo Shoji, Miki Yukio, Kawada Norifumi

    ONCOLOGY   99 ( 3 )   186 - 191   2021.02( ISSN:0030-2414

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    DOI: 10.1159/000510911

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  • 肝疾患診療連携拠点病院における肝炎医療コーディネーターの現状

    榎本 大, 日高 勲, 井上 泰輔, 磯田 広史, 井出 達也, 荒生 祥尚, 内田 義人, 井上 貴子, 池上 正, 柿崎 暁, 瀬戸山 博子, 島上 哲朗, 小川 浩司, 末次 淳, 井上 淳, 遠藤 美月, 永田 賢治, 是永 匡紹

    肝臓   62 ( 2 )   96 - 98   2021.02( ISSN:0451-4203

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    令和元年度の肝疾患診療連携拠点病院17施設における肝炎医療コーディネーター(肝炎Co)配置と活動状況についてアンケート調査を行った。その結果、17施設における現職肝炎Co数は合計480名で、施設により8〜77名と大きな差があった。実働率は全体で78%であったが、施設により7.9〜100%と差があった。最も多い職種は看護師の50%で、次いで臨床検査技師の11%、薬剤師の8.0%、管理栄養士の8.0%、医師の3.5%であった。尚、看護師のうち29.3%は肝疾患担当部署に配属されていた。

  • Transition rates to cirrhosis and liver cancer by age, gender, disease and treatment status in Asian chronic hepatitis B patients.

    Liu M, Tseng TC, Jun DW, Yeh ML, Trinh H, Wong GLH, Chen CH, Peng CY, Kim SE, Oh H, Kwak MS, Cheung M, Toyoda H, Hsu YC, Jeong JY, Yoon EL, Ungtrakul T, Zhang J, Xie Q, Ahn SB, Enomoto M, Shim JJ, Cunningham C, Jeong SW, Cho YK, Ogawa E, Huang R, Lee DH, Takahashi H, Tsai PC, Huang CF, Dai CY, Tseng CH, Yasuda S, Kozuka R, Li J, Wong C, Wong CC, Zhao C, Hoang J, Eguchi Y, Wu C, Tanaka Y, Gane E, Tanwandee T, Cheung R, Yuen MF, Lee HS, Yu ML, Kao JH, Yang HI, Nguyen MH

    Hepatology international   15 ( 1 )   71 - 81   2021.02( ISSN:1936-0533

  • Association of serum autotaxin levels with liver fibrosis in patients pretreatment and posttreatment with chronic hepatitis C Reviewed

    Takemura Kazuya, Takizawa Etsuko, Tamori Akihiro, Nakamae Mika, Kubota Hiroshi, Uchida-Kobayashi Sawako, Enomoto Masaru, Kawada Norifumi, Hino Masayuki

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   36 ( 1 )   217 - 224   2021.01( ISSN:0815-9319

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    DOI: 10.1111/jgh.15114

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  • Association of serum autotaxin levels with liver fibrosis in patients pretreatment and posttreatment with chronic hepatitis C.

    Takemura K, Takizawa E, Tamori A, Nakamae M, Kubota H, Uchida-Kobayashi S, Enomoto M, Kawada N, Hino M

    Journal of gastroenterology and hepatology   36 ( 1 )   217 - 224   2021.01( ISSN:0815-9319

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  • Hepatitis B Core-Related Antigen to Indicate High Viral Load: Systematic Review and Meta-Analysis of 10,397 Individual Participants.

    Yoshida K, Desbiolles A, Feldman SF, Ahn SH, Alidjinou EK, Atsukawa M, Bocket L, Brunetto MR, Buti M, Carey I, Caviglia GP, Chen EQ, Cornberg M, Enomoto M, Honda M, Zu Siederdissen CH, Ishigami M, Janssen HLA, Maasoumy B, Matsui T, Matsumoto A, Nishiguchi S, Riveiro-Barciela M, Takaki A, Tangkijvanich P, Toyoda H, van Campenhout MJH, Wang B, Wei L, Yang HI, Yano Y, Yatsuhashi H, Yuen MF, Tanaka E, Lemoine M, Tanaka Y, Shimakawa Y

    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association   19 ( 1 )   46 - 60.e8   2021.01( ISSN:1542-3565

  • Establishing Efficient Systems through Electronic Medical Records to Promote Intra-hospital Referrals of Hepatitis Virus Carriers to Hepatology Specialists: A Multicenter Questionnaire-based Survey of 1,281 Healthcare Professionals Reviewed

    Hidaka Isao, Enomoto Masaru, Sato Syuichi, Suetsugu Atsushi, Matono Tomomitsu, Ito Kiyoaki, Ogawa Koji, Inoue Jun, Horino Mika, Kondo Yasuteru, Sakaida Isao, Korenaga Masaaki

    一般社団法人 日本内科学会 INTERNAL MEDICINE   60 ( 3 )   337 - 343   2021( ISSN:0918-2918

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    <p><b>Objective </b>Persistent hepatitis B virus (HBV) and hepatitis C virus (HCV) infections are major causative factors of hepatic cirrhosis and hepatocellular carcinoma. However, the development of antiviral treatment has enabled their suppression. Therefore, the early detection and treatment of these infections are important. The objective of this study was to assess the level of awareness among healthcare professionals about hepatitis virus infection and electronic medical records alert system. </p><p><b>Methods </b>We surveyed healthcare professionals from 10 institutions with electronic medical records alert systems. All participants attended a lecture about the reactivation risk due to HBV infections, the most recent antiviral treatment for HCV infections, and the electronic medical records alert system. They participated in a questionnaire-based survey about their awareness of these infections, current status of intra-hospital referral, need for intra-hospital referrals before and after the lecture, and reasons for non-referral of patients to specialists. </p><p><b>Results </b>Responses were received from 1,281 healthcare professionals. Physicians and pharmacists had a high level of awareness about HBV and HCV. Among physicians, the level of awareness of those in the surgical field and other fields was significantly lower than that of the professionals in the internal medicine field. The awareness of the need to refer patients to hepatologists increased from 84.7-85.4% before to 93.0% after the lecture. The most frequent reasons for not referring patients previously were "I had no knowledge and/or interest" (28.1% of responses) and "All I did was explain the results orally" (24.2%). </p><p><b>Conclusion </b>More widespread education of healthcare personnel is important to increase the number of individuals receiving appropriate treatment from specialist physicians. </p>

    DOI: 10.2169/internalmedicine.4748-20

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  • Lenvatinib-Induced Tumor-Related Hemorrhages in Patients with Large Hepatocellular Carcinomas.

    Uchida-Kobayashi S, Kageyama K, Yamamoto A, Ikenaga H, Yoshida K, Kotani K, Kimura K, Odagiri N, Hagihara A, Fujii H, Enomoto M, Tamori A, Kubo S, Miki Y, Kawada N

    Oncology   99 ( 3 )   186 - 191   2021( ISSN:0030-2414

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  • Establishing Efficient Systems through Electronic Medical Records to Promote Intra-hospital Referrals of Hepatitis Virus Carriers to Hepatology Specialists: A Multicenter Questionnaire-based Survey of 1,281 Healthcare Professionals

    Hidaka Isao, Enomoto Masaru, Sato Syuichi, Suetsugu Atsushi, Matono Tomomitsu, Ito Kiyoaki, Ogawa Koji, Inoue Jun, Horino Mika, Kondo Yasuteru, Sakaida Isao, Korenaga Masaaki

    Internal Medicine   60 ( 3 )   337 - 343   2021( ISSN:0918-2918

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    <p><b>Objective </b>Persistent hepatitis B virus (HBV) and hepatitis C virus (HCV) infections are major causative factors of hepatic cirrhosis and hepatocellular carcinoma. However, the development of antiviral treatment has enabled their suppression. Therefore, the early detection and treatment of these infections are important. The objective of this study was to assess the level of awareness among healthcare professionals about hepatitis virus infection and electronic medical records alert system. </p><p><b>Methods </b>We surveyed healthcare professionals from 10 institutions with electronic medical records alert systems. All participants attended a lecture about the reactivation risk due to HBV infections, the most recent antiviral treatment for HCV infections, and the electronic medical records alert system. They participated in a questionnaire-based survey about their awareness of these infections, current status of intra-hospital referral, need for intra-hospital referrals before and after the lecture, and reasons for non-referral of patients to specialists. </p><p><b>Results </b>Responses were received from 1,281 healthcare professionals. Physicians and pharmacists had a high level of awareness about HBV and HCV. Among physicians, the level of awareness of those in the surgical field and other fields was significantly lower than that of the professionals in the internal medicine field. The awareness of the need to refer patients to hepatologists increased from 84.7-85.4% before to 93.0% after the lecture. The most frequent reasons for not referring patients previously were "I had no knowledge and/or interest" (28.1% of responses) and "All I did was explain the results orally" (24.2%). </p><p><b>Conclusion </b>More widespread education of healthcare personnel is important to increase the number of individuals receiving appropriate treatment from specialist physicians. </p>

    DOI: 10.2169/internalmedicine.4748-20

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  • A novel noninvasive formula for predicting cirrhosis in patients with chronic hepatitis C.

    Atsukawa M, Tsubota A, Kondo C, Uchida-Kobayashi S, Takaguchi K, Tsutsui A, Nozaki A, Chuma M, Hidaka I, Ishikawa T, Iwasa M, Tamai Y, Tobari M, Matsuura K, Nagura Y, Abe H, Kato K, Suzuki K, Okubo T, Arai T, Itokawa N, Toyoda H, Enomoto M, Tamori A, Tanaka Y, Kawada N, Takei Y, Iwakiri K

    PloS one   16 ( 9 )   e0257166   2021

  • HCV Cure Rates are Reduced in Patients with Active but not Inactive Hepatocellular Carcinoma- A Practice Implication. Reviewed

    Ogawa E, Toyoda H, Iio E, Jun DW, Huang CF, Enomoto M, Hsu YC, Haga H, Iwane S, Wong G, Lee DH, Tada T, Liu CH, Chuang WL, Hayashi J, Cheung R, Yasuda S, Tseng CH, Takahashi H, Tran S, Yeo YH, Henry L, Barnett SD, Nomura H, Nakamuta M, Dai CY, Huang JF, Yang HI, Lee MH, Jung Jun M, Kao JH, Eguchi Y, Ueno Y, Tamori A, Furusyo N, Yu ML, Tanaka Y, Nguyen MH, REAL-C Investigators, Ahn SB, Azuma K, Dohmen K, Yoon Jeong J, Jung JH, Kajiwara E, Kato M, Kawano A, Koyanagi T, Ooho A, Park SH, Satoh T, S

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America   71 ( 11 )   2840 - 2848   2020.12( ISSN:1058-4838

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    DOI: 10.1093/cid/ciz1160

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  • Anti-fibrotic treatments for chronic liver diseases: the present and the future. Reviewed

    Odagiri N, Matsubara T, Sato-Matsubara M, Fujii H, Enomoto M, Kawada N

    Clinical and molecular hepatology   2020.12( ISSN:2287-2728

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.3350/cmh.2020.0187

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  • HCC risk post-SVR with DAAs in East Asians: findings from the REAL-C cohort Reviewed

    Tanaka Yasuhito, Ogawa Eiichi, Huang Chung-Feng, Toyoda Hidenori, Jun Dae Won, Tseng Cheng-Hao, Hsu Yao-Chun, Enomoto Masaru, Takahashi Hirokazu, Furusyo Norihiro, Yeh Ming-Lun, Iio Etsuko, Yasuda Satoshi, Lam Carla Pui-Mei, Lee Dong Hyun, Haga Hiroaki, Yoon Eileen L., Ahn Sang Bong, Wong Grace, Nakamuta Makoto, Nomura Hideyuki, Tsai Pei-Chien, Jung Jang Han, Song Do Seon, Dang Hansen, Maeda Mayumi, Henry Linda, Cheung Ramsey, Yuen Man-Fung, Ueno Yoshiyuki, Eguchi Yuichiro, Tamori Akihiro, Yu Ming-Lung, Hayashi Jun, Nguyen Mindie H.

    HEPATOLOGY INTERNATIONAL   14 ( 6 )   1023 - 1033   2020.12( ISSN:1936-0533

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    DOI: 10.1007/s12072-020-10105-2

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  • Hepatocellular carcinoma incidence with tenofovir versus entecavir in chronic hepatitis B: a systematic review and meta-analysis Reviewed

    Tseng Cheng-Hao, Hsu Yao-Chun, Chen Tzu-Haw, Ji Fanpu, Chen I-Sung, Tsai Ying-Nan, Hai Hoang, Le Thi Thanh Thuy, Hosaka Tetsuya, Sezaki Hitomi, Borghi John A., Cheung Ramsey, Enomoto Masaru, Nguyen Mindie H.

    LANCET GASTROENTEROLOGY & HEPATOLOGY   5 ( 12 )   1039 - 1052   2020.12

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    DOI: 10.1016/S2468-1253(20)30249-1

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  • Hepatocellular carcinoma incidence with tenofovir versus entecavir in chronic hepatitis B: a systematic review and meta-analysis.

    Tseng CH, Hsu YC, Chen TH, Ji F, Chen IS, Tsai YN, Hai H, Thuy LTT, Hosaka T, Sezaki H, Borghi JA, Cheung R, Enomoto M, Nguyen MH

    The lancet. Gastroenterology & hepatology   5 ( 12 )   1039 - 1052   2020.12( ISSN:24681253

  • HCC risk post-SVR with DAAs in East Asians: findings from the REAL-C cohort.

    Tanaka Y, Ogawa E, Huang CF, Toyoda H, Jun DW, Tseng CH, Hsu YC, Enomoto M, Takahashi H, Furusyo N, Yeh ML, Iio E, Yasuda S, Lam CP, Lee DH, Haga H, Yoon EL, Ahn SB, Wong G, Nakamuta M, Nomura H, Tsai PC, Jung JH, Song DS, Dang H, Maeda M, Henry L, Cheung R, Yuen MF, Ueno Y, Eguchi Y, Tamori A, Yu ML, Hayashi J, Nguyen MH, REAL-C Investigators

    Hepatology international   14 ( 6 )   1023 - 1033   2020.12( ISSN:1936-0533

  • 後腹膜原発異所性肝細胞癌の1例

    林下 晃士, 打田 佐和子[小林], 吉田 香奈子, 小田桐 直志, 小谷 晃平, 元山 宏行, 藤井 英樹, 萩原 淳司, 宮崎 徹, 西岡 孝芳, 新川 寛二, 田中 肖吾, 榎本 大, 田守 昭博, 久保 正二, 河田 則文

    肝臓   61 ( 11 )   597 - 606   2020.11( ISSN:0451-4203

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    症例は59歳、女性。腹腔内腫瘤の精査・加療目的で入院となった。腹部ダイナミックCT像上にて肝外側区域背側から膵上縁におよぶ、動脈相で辺縁が不均一に濃染し、門脈相でwash outを呈する90mm大の腫瘤を認めた。AFPおよびPIVKA-IIの上昇もあり、尾状葉原発肝外突出型肝細胞癌と診断し開腹したところ、腫瘤は肝と線維性癒合のみであったが、総肝動脈が腫瘤を貫いており、同部位を遺残する摘出術を施行した。病理学的に低分化型異所性肝細胞癌と診断した。遺残部位の増大に対しレンバチニブメシル酸塩(レンバチニブ)を導入し、開始2ヵ月間の画像検査で部分奏効と判定したものの、開始後3ヵ月には腫瘍が増大したため進行(PD)と判断し、Best supportive careに移行した。レンバチニブ開始後132日で癌死した。進行異所性肝細胞癌に対してレンバチニブを投与した報告はなく、貴重な症例と考えられた。(著者抄録)

  • Destructive thyroiditis presenting as thyrotoxicosis followed by hypothyroidism during lenvatinib therapy for hepatocellular carcinoma Reviewed

    Suoh Maito, Fujii Hideki, Nagata Yuki, Kotani Kohei, Hagihara Atsushi, Enomoto Masaru, Tamori Akihiro, Inaba Masaaki, Kawada Norifumi

    CLINICAL JOURNAL OF GASTROENTEROLOGY   13 ( 5 )   860 - 866   2020.10( ISSN:1865-7257

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s12328-020-01107-6

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  • Risk factors for hepatocellular carcinoma in treated chronic hepatitis C patients-Relationship to smoking and alcohol Reviewed

    Matsuura Tomoka, Ohfuji Satoko, Enomoto Masaru, Tamori Akihiro, Kubo Shoji, Kioka Kiyohide, Kawada Norifumi, Fukushima Wakaba

    JGH OPEN   4 ( 5 )   867 - 875   2020.10( ISSN:2397-9070

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/jgh3.12331

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  • Pilot study of tenofovir disoproxil fumarate and pegylated interferon-alpha 2a add-on therapy in Japanese patients with chronic hepatitis B Reviewed

    Matsumoto Akihiro, Nishiguchi Shuhei, Enomoto Hirayuki, Tanaka Yasuhito, Shinkai Noboru, Okuse Chiaki, Kang Jong-Hon, Matsui Takeshi, Miyase Shiho, Yatsuhashi Hiroshi, Nagaoka Shinya, Kanda Tatsuo, Enomoto Masaru, Yamada Ryoko, Hiramatsu Naoki, Saito Satoru, Takaguchi Koichi, Ito Kiyoaki, Masaki Tsutomu, Morihara Daisuke, Tsuge Masataka, Chayama Kazuaki, Ikeda Fusao, Kagawa Tatehiro, Kondo Yasuteru, Murata Kazumoto, Tanaka Eiji

    JOURNAL OF GASTROENTEROLOGY   55 ( 10 )   977 - 989   2020.10( ISSN:0944-1174

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    DOI: 10.1007/s00535-020-01707-6

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  • High dropout rate from aftercare program of antihepatitis C therapy for patients with history of injection drug use Reviewed

    Tamori Akihiro, Uchida-Kobayashi Sawako, Kozuka Ritsuzo, Motoyama Hiroyuki, Yoshida Kanako, Odagiri Naoshi, Kotani Kohei, Kawamura Etsushi, Fujii Hideki, Hagihara Atsushi, Enomoto Masaru, Kawada Norifumi

    JGH OPEN   4 ( 5 )   964 - 969   2020.10( ISSN:2397-9070

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    DOI: 10.1002/jgh3.12376

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  • TGF-β1-driven reduction of cytoglobin leads to oxidative DNA damage in stellate cells during non-alcoholic steatohepatitis.

    Okina Y, Sato-Matsubara M, Matsubara T, Daikoku A, Longato L, Rombouts K, Thanh Thuy LT, Ichikawa H, Minamiyama Y, Kadota M, Fujii H, Enomoto M, Ikeda K, Yoshizato K, Pinzani M, Kawada N

    Journal of hepatology   73 ( 4 )   882 - 895   2020.10( ISSN:0168-8278

  • Risk factors for hepatocellular carcinoma in treated chronic hepatitis C patients-Relationship to smoking and alcohol.

    Matsuura T, Ohfuji S, Enomoto M, Tamori A, Kubo S, Kioka K, Kawada N, Fukushima W

    JGH open : an open access journal of gastroenterology and hepatology   4 ( 5 )   867 - 875   2020.10

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  • Pilot study of tenofovir disoproxil fumarate and pegylated interferon-alpha 2a add-on therapy in Japanese patients with chronic hepatitis B.

    Matsumoto A, Nishiguchi S, Enomoto H, Tanaka Y, Shinkai N, Okuse C, Kang JH, Matsui T, Miyase S, Yatsuhashi H, Nagaoka S, Kanda T, Enomoto M, Yamada R, Hiramatsu N, Saito S, Takaguchi K, Ito K, Masaki T, Morihara D, Tsuge M, Chayama K, Ikeda F, Kagawa T, Kondo Y, Murata K, Tanaka E

    Journal of gastroenterology   55 ( 10 )   977 - 989   2020.10( ISSN:0944-1174

  • High dropout rate from aftercare program of antihepatitis C therapy for patients with history of injection drug use.

    Tamori A, Uchida-Kobayashi S, Kozuka R, Motoyama H, Yoshida K, Odagiri N, Kotani K, Kawamura E, Fujii H, Hagihara A, Enomoto M, Kawada N

    JGH open : an open access journal of gastroenterology and hepatology   4 ( 5 )   964 - 969   2020.10

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  • Destructive thyroiditis presenting as thyrotoxicosis followed by hypothyroidism during lenvatinib therapy for hepatocellular carcinoma.

    Suoh M, Fujii H, Nagata Y, Kotani K, Hagihara A, Enomoto M, Tamori A, Inaba M, Kawada N

    Clinical journal of gastroenterology   13 ( 5 )   860 - 866   2020.10( ISSN:18657257

  • Utility of minimally invasive measurement of hepatic venous pressure gradient via the peripheral antecubital vein. Reviewed

    Yamamoto A, Kawada N, Jogo A, Murai K, Kotani K, Kageyama K, Hamamoto S, Sohgawa E, Uchida-Kobayashi S, Enomoto M, Tamori A, Miki Y

    Gut   2020.08( ISSN:0017-5749

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    DOI: 10.1136/gutjnl-2020-322367

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  • Early Change in the Plasma Levels of Circulating Soluble Immune Checkpoint Proteins in Patients with Unresectable Hepatocellular Carcinoma Treated by Lenvatinib or Transcatheter Arterial Chemoembolization.

    Odagiri N, Hai H, Thuy LTT, Dong MP, Suoh M, Kotani K, Hagihara A, Uchida-Kobayashi S, Tamori A, Enomoto M, Kawada N

    Cancers   12 ( 8 )   1 - 16   2020.07( ISSN:2072-6694

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  • Lenvatinib-Induced Tumor-Related Hemorrhage in Patients With Unresectable Hepatocellular Carcinoma. Reviewed

    Kotani K, Uchida-Kobayashi S, Yoshida K, Kawamura E, Fujii H, Hagihara A, Enomoto M, Tamori A, Kawada N

    The American journal of gastroenterology   2020.07( ISSN:0002-9270

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.14309/ajg.0000000000000747

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  • Serum Mac-2-binding protein glycosylation isomer predicts esophagogastric varices in cirrhotic patients with chronic hepatitis C virus infection treated with IFN-free direct-acting antiviral agent: M2BPGi levels predict varices in SVR patients.

    Kikukawa K, Uchida-Kobayashi S, Tamori A, Yoshida K, Kotani K, Motoyama H, Kozuka R, Hagihara A, Fujii H, Morikawa H, Enomoto M, Murakami Y, Kawada N

    Annals of hepatology   19 ( 4 )   367 - 372   2020.07( ISSN:1665-2681

  • Post-Treatment M2BPGi Level and the Rate of Autotaxin Reduction are Predictive of Hepatocellular Carcinoma Development after Antiviral Therapy in Patients with Chronic Hepatitis C.

    Takemura K, Takizawa E, Tamori A, Nakamae M, Kubota H, Uchida-Kobayashi S, Enomoto M, Kawada N, Hino M

    International journal of molecular sciences   21 ( 12 )   1 - 16   2020.06( ISSN:16616596

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  • Post-Treatment M2BPGi Level and the Rate of Autotaxin Reduction are Predictive of Hepatocellular Carcinoma Development after Antiviral Therapy in Patients with Chronic Hepatitis C Reviewed

    Takemura Kazuya, Takizawa Etsuko, Tamori Akihiro, Nakamae Mika, Kubota Hiroshi, Uchida-Kobayashi Sawako, Enomoto Masaru, Kawada Norifumi, Hino Masayuki

    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES   21 ( 12 )   2020.06

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    DOI: 10.3390/ijms21124517

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  • Cure With Interferon-Free Direct-Acting Antiviral Is Associated With Increased Survival in Patients With Hepatitis C Virus-Related Hepatocellular Carcinoma From Both East and West.

    Dang H, Yeo YH, Yasuda S, Huang CF, Iio E, Landis C, Jun DW, Enomoto M, Ogawa E, Tsai PC, Le A, Liu M, Maeda M, Nguyen B, Ramrakhiani N, Henry L, Cheung R, Tamori A, Kumada T, Tanaka Y, Yu ML, Toyoda H, Nguyen MH

    Hepatology (Baltimore, Md.)   71 ( 6 )   1910 - 1922   2020.06( ISSN:0270-9139

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  • HBV再活性化対策のため介入投与された核酸アナログは中止可能か

    田守 昭博, 榎本 大, 河田 則文

    肝臓   61 ( 5 )   244 - 244   2020.05( ISSN:04514203

  • The Moral of Hepatic Fibrosis: Don't Always Believe Noninvasive Fibrosis Measurements. Reviewed

    Enomoto M, Kawada N

    Digestive diseases and sciences   65 ( 5 )   1293 - 1295   2020.05( ISSN:0163-2116

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    DOI: 10.1007/s10620-019-06035-1

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  • Author Correction: Development of a novel anti-hepatitis B virus agent via Sp1.

    Hayakawa M, Umeyama H, Iwadate M, Taguchi YH, Yano Y, Honda T, Itami-Matsumoto S, Kozuka R, Enomoto M, Tamori A, Kawada N, Murakami Y

    Scientific reports   10 ( 1 )   7015   2020.04

  • Clinical significance of circulating soluble immune checkpoint proteins in sorafenib-treated patients with advanced hepatocellular carcinoma. Reviewed

    Dong MP, Enomoto M, Thuy LTT, Hai H, Hieu VN, Hoang DV, Iida-Ueno A, Odagiri N, Amano-Teranishi Y, Hagihara A, Fujii H, Uchida-Kobayashi S, Tamori A, Kawada N

    Scientific reports   10 ( 1 )   3392   2020.02

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41598-020-60440-5

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  • Clinical significance of circulating soluble immune checkpoint proteins in sorafenib-treated patients with advanced hepatocellular carcinoma. Reviewed

    Minh Phuong Dong, Masaru Enomoto, Le Thi Thanh Thuy, Hoang Hai, Vu Ngoc Hieu, Dinh Viet Hoang, Ayako Iida-Ueno, Naoshi Odagiri, Yuga Amano-Teranishi, Atsushi Hagihara, Hideki Fujii, Sawako Uchida-Kobayashi, Akihiro Tamori, Norifumi Kawada

    Scientific reports   10 ( 1 )   3392 - 3392   2020.02

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    Publishing type:Research paper (scientific journal)   International / domestic magazine:International journal  

    In hepatocellular carcinoma (HCC), the clinical significance of soluble immune checkpoint protein levels as predictors of patient outcomes or therapeutic responses has yet to be defined. This study profiled the baseline levels of sixteen soluble checkpoint proteins and their changes following sorafenib treatment for HCC. Plasma samples were obtained from 53 patients with advanced HCC at baseline, week 1, 2 and 4 of sorafenib treatment and tested the concentrations of 16 soluble checkpoint proteins using multiplexed fluorescent bead-based immunoassays. Multivariate analysis showed high sBTLA levels at baseline were an independent predictor of poor overall survival (p = 0.038). BTLA was highly expressed in T cells and macrophages in peritumoral areas. At week 2, sCD27 levels were decreased compared to baseline. By contrast, the concentrations of most inhibitory proteins, including sBTLA, sLAG-3, sCTLA-4, sPD-1, sCD80, sCD86 and sPD-L1, had significantly increased. The fold-changes of soluble checkpoint receptors and their ligands, including sCTLA-4 with sCD80/sCD86, sPD-1 with sPD-L1; and the fold-changes of sCTLA-4 with sBTLA or sPD-1 were positively correlated. sBTLA may be a good biomarker for predicting overall survival in HCC patients. Sorafenib treatment in patients with advanced HCC revealed dynamic changes of soluble checkpoint protein levels.

    DOI: 10.1038/s41598-020-60440-5

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  • Highly Sensitive Circulating MicroRNA Panel for Accurate Detection of Hepatocellular Carcinoma in Patients With Liver Disease Reviewed

    Yamamoto Yusuke, Kondo Shunsuke, Matsuzaki Juntaro, Esaki Minoru, Okusaka Takuji, Shimada Kazuaki, Muralcatni Yoshild, Enomoto Masaru, Tamori Akihiro, Kato Ken, Aoki Yoshiaki, Takizawa Satoko, Sakamoto Hiromi, Niida Shumpei, Takeshita Fumitaka, Ochiya Takahiro

    HEPATOLOGY COMMUNICATIONS   4 ( 2 )   284 - 297   2020.02

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    DOI: 10.1002/hep4.1451

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  • Tenofovir Versus Entecavir for Hepatocellular Carcinoma Prevention in an International Consortium of Chronic Hepatitis B.

    Hsu YC, Wong GL, Chen CH, Peng CY, Yeh ML, Cheung KS, Toyoda H, Huang CF, Trinh H, Xie Q, Enomoto M, Liu L, Yasuda S, Tanaka Y, Kozuka R, Tsai PC, Huang YT, Wong C, Huang R, Jang TY, Hoang J, Yang HI, Li J, Lee DH, Takahashi H, Zhang JQ, Ogawa E, Zhao C, Liu C, Furusyo N, Eguchi Y, Wong C, Wu C, Kumada T, Yuen MF, Yu ML, Nguyen MH

    The American journal of gastroenterology   115 ( 2 )   271 - 280   2020.02( ISSN:0002-9270

  • Highly Sensitive Circulating MicroRNA Panel for Accurate Detection of Hepatocellular Carcinoma in Patients With Liver Disease. Reviewed

    Yusuke Yamamoto, Shunsuke Kondo, Juntaro Matsuzaki, Minoru Esaki, Takuji Okusaka, Kazuaki Shimada, Yoshiki Murakami, Masaru Enomoto, Akihiro Tamori, Ken Kato, Yoshiaki Aoki, Satoko Takizawa, Hiromi Sakamoto, Shumpei Niida, Fumitaka Takeshita, Takahiro Ochiya

    Hepatology communications   4 ( 2 )   284 - 297   2020.02

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    Publishing type:Research paper (scientific journal)   International / domestic magazine:International journal  

    Hepatocellular carcinoma (HCC) is the fourth leading cause of cancer deaths worldwide. The high mortality rate in HCC is largely due to the difficulty of early detection. In this study, to improve patient outcomes, serum samples from 345 patients with HCC, 46 patients with chronic hepatitis (CH), 93 patients with liver cirrhosis (LC), and 1,033 healthy individuals were analyzed with microRNA (miRNA) microarrays. We investigated the diagnostic potential of circulating miRNAs in serum and developed a detection model of HCC, including early stage. A diagnostic model was constructed based on the expression levels of a combination of miRNAs in a discovery set. We selected 52 miRNAs that had altered expressions according to disease progression status, established the diagnostic model with a combination of eight miRNAs in the discovery set, and tested the model in a validation set. The diagnostic values for discriminating cancer from HCC at-risk control samples were as follows: area under the curve, 0.99; sensitivity, 97.7%; specificity, 94.7%. With this model, 98% of stage I HCC cases were detected; these results were much better than those observed from conventional methods. Conclusion: Circulating miRNAs could serve as biomarkers for the accurate detection of HCC. Because the diagnostic accuracy was maintained even in stage I, this may represent an accurate detection method even for early stage HCC.

    DOI: 10.1002/hep4.1451

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  • Real-World Effectiveness From the Asia Pacific Rim Liver Consortium for HBV Risk Score for the Prediction of Hepatocellular Carcinoma in Chronic Hepatitis B Patients Treated With Oral Antiviral Therapy. Reviewed

    Yang HI, Yeh ML, Wong GL, Peng CY, Chen CH, Trinh HN, Cheung KS, Xie Q, Su TH, Kozuka R, Lee DH, Ogawa E, Zhao C, Ning HB, Huang R, Li J, Zhang JQ, Ide T, Xing H, Iwane S, Takahashi H, Wong C, Wong C, Lin CH, Hoang J, Le A, Henry L, Toyoda H, Ueno Y, Gane EJ, Eguchi Y, Kurosaki M, Wu C, Liu C, Shang J, Furusyo N, Enomoto M, Kao JH, Yuen MF, Yu ML, Nguyen MH

    The Journal of infectious diseases   221 ( 3 )   389 - 399   2020.01( ISSN:0022-1899

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    DOI: 10.1093/infdis/jiz477

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  • Real-World Effectiveness From the Asia Pacific Rim Liver Consortium for HBV Risk Score for the Prediction of Hepatocellular Carcinoma in Chronic Hepatitis B Patients Treated With Oral Antiviral Therapy. Reviewed

    Yang HI, Yeh ML, Wong GL, Peng CY, Chen CH, Trinh HN, Cheung KS, Xie Q, Su TH, Kozuka R, Lee DH, Ogawa E, Zhao C, Ning HB, Huang R, Li J, Zhang JQ, Ide T, Xing H, Iwane S, Takahashi H, Wong C, Wong C, Lin CH, Hoang J, Le A, Henry L, Toyoda H, Ueno Y, Gane EJ, Eguchi Y, Kurosaki M, Wu C, Liu C, Shang J, Furusyo N, Enomoto M, Kao JH, Yuen MF, Yu ML, Nguyen MH

    The Journal of infectious diseases   221 ( 3 )   389 - 399   2020.01( ISSN:0022-1899

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    BACKGROUND: Patients on oral antiviral (OAV) therapy remain at hepatocellular carcinoma (HCC) risk. Risk prediction tools distinguishing treated patients with residual HCC risk are limited. The aim of this study was to develop an accurate, precise, simple-to-use HCC risk score using routine clinical variables among a treated Asian cohort. METHODS: Adult Asian chronic hepatitis B (CHB) patients on OAV were recruited from 25 centers in the United States and the Asia-Pacific region. Excluded persons were coinfected with hepatitis C, D, or human immunodeficiency virus, had HCC before or within 1 year of study entry, or their follow-up was <1 year. Patients were randomized to derivation and validation cohorts on a 2:1 ratio. Statistically significant predictors from multivariate modeling formed the Real-world Effectiveness from the Asia Pacific Rim Liver Consortium for HBV (REAL-B) score. RESULTS: A total of 8048 patients were randomized to the derivation (n = 5365) or validation group (n = 2683). The REAL-B model included 7 variables (male gender, age, alcohol use, diabetes, baseline cirrhosis, platelet count, and alpha fetoprotein), and scores were categorized as follows: 0-3 low risk, 4-7 moderate risk, and 8-13 high risk. Area under receiver operating characteristics were >0.80 for HCC risk at 3, 5, and 10 years, and these were significantly higher than other risk models (p < .001). CONCLUSIONS: The REAL-B score provides 3 distinct risk categories for HCC development in Asian CHB patients on OAV guiding HCC surveillance strategy.

    DOI: 10.1093/infdis/jiz477

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  • Development of a novel anti-hepatitis B virus agent via Sp1 Reviewed

    Hayakawa Michiyo, Umeyama Hideaki, Iwadate Mitsuo, Taguchi Y. -H., Yano Yoshihiko, Honda Takashi, Itami-Matsumoto Saori, Kozuka Ritsuzo, Enomoto Masaru, Tamori Akihiro, Kawada Norifumi, Murakami Yoshiki

    SCIENTIFIC REPORTS   10 ( 1 )   47   2020.01( ISSN:2045-2322

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41598-019-56842-9

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  • Development of a novel anti-hepatitis B virus agent via Sp1.

    Hayakawa M, Umeyama H, Iwadate M, Taguchi YH, Yano Y, Honda T, Itami-Matsumoto S, Kozuka R, Enomoto M, Tamori A, Kawada N, Murakami Y

    Scientific reports   10 ( 1 )   47   2020.01

  • The Moral of Hepatic Fibrosis: Don't Always Believe Noninvasive Fibrosis Measurements. Reviewed

    Enomoto M, Kawada N

    Digestive diseases and sciences   2020.01( ISSN:0163-2116

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s10620-019-06035-1

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  • The Administration of Tenofovir Disoproxil Fumarate for Pregnant Japanese Women with Chronic Hepatitis B Reviewed

    Suoh Maito, Tamori Akihiro, Amano-Teranishi Yuga, Nakai Takashi, Enomoto Masaru, Kawasaki Yasuko, Kioka Kiyohide, Kawada Norifumi

    一般社団法人 日本内科学会 INTERNAL MEDICINE   59 ( 2 )   205 - 210   2020( ISSN:0918-2918

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    <p>The appropriate management of hepatitis B virus (HBV) infection during pregnancy has not been established in Japan. We herein report five HBV-infected pregnant Japanese women who received tenofovir disoproxil fumarate (TDF). Two of them had been born after the introduction of nationwide immunoprophylaxis and were vertically infected with HBV, highlighting the need to address mother-to-child transmission further. In both entecavir-experienced and nucleoside/nucleotide analog-naïve mothers, TDF suppressed HBV replication without serious adverse events. All five children were free from congenital disorders, growth impairment, and HBV infection. TDF showed safety and efficacy for pregnant woman with chronic hepatitis B and might have helped prevent mother-to-child transmission. </p>

    DOI: 10.2169/internalmedicine.3504-19

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    CiNii Article

  • Serum Mac-2-binding protein glycosylation isomer predicts esophagogastric varices in cirrhotic patients with chronic hepatitis C virus infection treated with IFN-free direct-acting antiviral agent: M2BPGi levels predict varices in SVR patients Reviewed

    Kikukawa Kanako, Uchida-Kobayashi Sawako, Tamori Akihiro, Yoshida Kanako, Kotani Kohei, Motoyama Hiroyuki, Kozuka Ritsuzo, Hagihara Atsushi, Fujii Hideki, Morikawa Hiroyasu, Enomoto Masaru, Murakami Yoshiki, Kawada Norifumi

    ANNALS OF HEPATOLOGY   19 ( 4 )   367 - 372   2020( ISSN:1665-2681

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.aohep.2020.04.002

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  • The Administration of Tenofovir Disoproxil Fumarate for Pregnant Japanese Women with Chronic Hepatitis B

    Suoh Maito, Tamori Akihiro, Amano-Teranishi Yuga, Nakai Takashi, Enomoto Masaru, Kawasaki Yasuko, Kioka Kiyohide, Kawada Norifumi

    Internal Medicine   59 ( 2 )   205 - 210   2020( ISSN:0918-2918

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    Publishing type:Research paper (scientific journal)   International / domestic magazine:Domestic journal  

    <p>The appropriate management of hepatitis B virus (HBV) infection during pregnancy has not been established in Japan. We herein report five HBV-infected pregnant Japanese women who received tenofovir disoproxil fumarate (TDF). Two of them had been born after the introduction of nationwide immunoprophylaxis and were vertically infected with HBV, highlighting the need to address mother-to-child transmission further. In both entecavir-experienced and nucleoside/nucleotide analog-naïve mothers, TDF suppressed HBV replication without serious adverse events. All five children were free from congenital disorders, growth impairment, and HBV infection. TDF showed safety and efficacy for pregnant woman with chronic hepatitis B and might have helped prevent mother-to-child transmission. </p>

    DOI: 10.2169/internalmedicine.3504-19

    PubMed

    CiNii Article

  • Circulating Exosomal miRNA Profiles Predict the Occurrence and Recurrence of Hepatocellular Carcinoma in Patients with Direct-Acting Antiviral-Induced Sustained Viral Response Reviewed

    Itami-Matsumoto Saori, Hayakawa Michiyo, Uchida-Kobayashi Sawako, Enomoto Masaru, Tamori Akihiro, Mizuno Kazuyuki, Toyoda Hidenori, Tamura Takeyuki, Akutsu Tatsuya, Ochiya Takahiro, Kawada Norifumi, Murakami Yoshiki

    BIOMEDICINES   7 ( 4 )   2019.12

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    DOI: 10.3390/biomedicines7040087

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  • Hepatitis C virus recurrence in two patients who achieved sustained viral response with interferon-free direct-acting antiviral therapy: reinfection or relapse? Reviewed

    Yukawa Yoshimi, Tamori Akihiro, Iio Etsuko, Ogawa Shintaro, Yoshida Kanako, Uchida-Kobayashi Sawako, Enomoto Masaru, Tanaka Yasuhito, Kawada Norifumi

    CLINICAL JOURNAL OF GASTROENTEROLOGY   12 ( 6 )   598 - 602   2019.12( ISSN:1865-7257

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s12328-019-01001-w

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  • Last crusade against HCV: Direct-acting antiviral treatment for marginalized populations Reviewed

    Fujii Hideki, Enomoto Masaru, Murakami Yoshiki, Hagihara Atsushi, Kawada Norifumi, Saito Shinobu

    JOURNAL OF VIRAL HEPATITIS   26 ( 12 )   1501 - 1501   2019.12( ISSN:1352-0504

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/jvh.13190

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  • Intention-to-treat assessment of glecaprevir plus pibrentasvir combination therapy for patients with chronic hepatitis C in the real world Reviewed

    Tamori Akihiro, Inoue Kazuaki, Kagawa Tatehiro, Takaguchi Koichi, Nouso Kazuhiro, Iwasaki Yoshiaki, Minami Masahito, Hai Hoang, Enomoto Masaru, Kawada Norifumi

    HEPATOLOGY RESEARCH   49 ( 12 )   1365 - 1373   2019.12( ISSN:1386-6346

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/hepr.13410

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  • Last crusade against HCV: Direct-acting antiviral treatment for marginalized populations.

    Fujii H, Enomoto M, Murakami Y, Hagihara A, Kawada N, Saito S

    Journal of viral hepatitis   26 ( 12 )   1501   2019.12( ISSN:1352-0504

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  • Intention-to-treat assessment of glecaprevir + pibrentasvir combination therapy for patients with chronic hepatitis C in the real world.

    Tamori A, Inoue K, Kagawa T, Takaguchi K, Nouso K, Iwasaki Y, Minami M, Hai H, Enomoto M, Kawada N

    Hepatology research : the official journal of the Japan Society of Hepatology   49 ( 12 )   1365 - 1373   2019.12( ISSN:1386-6346

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  • Hepatitis C virus recurrence in two patients who achieved sustained viral response with interferon-free direct-acting antiviral therapy: reinfection or relapse?

    Yukawa Y, Tamori A, Iio E, Ogawa S, Yoshida K, Uchida-Kobayashi S, Enomoto M, Tanaka Y, Kawada N

    Clinical journal of gastroenterology   12 ( 6 )   598 - 602   2019.12( ISSN:18657257

  • HCV Cure Rates are Reduced in Patients with Active but not Inactive Hepatocellular Carcinoma- A Practice Implication. Reviewed

    Ogawa E, Toyoda H, Iio E, Jun DW, Huang CF, Enomoto M, Hsu YC, Haga H, Iwane S, Wong G, Lee DH, Tada T, Liu CH, Chuang WL, Hayashi J, Cheung R, Yasuda S, Tseng CH, Takahashi H, Tran S, Yeo YH, Henry L, Barnett SD, Nomura H, Nakamuta M, Dai CY, Huang JF, Yang HI, Lee MH, Jung Jun M, Kao JH, Eguchi Y, Ueno Y, Tamori A, Furusyo N, Yu ML, Tanaka Y, Nguyen MH, REAL-C Investigators., Ahn SB, Azuma K, Dohmen K, Yoon Jeong J, Jung JH, Kajiwara E, Kato M, Kawano A, Koyanagi T, Ooho A, Park SH, Satoh T, Shimoda S, Song DS, Takahashi K, Yeh ML, Yoon EL

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America   2019.11( ISSN:1058-4838

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/cid/ciz1160

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  • Circulating Exosomal miRNA Profiles Predict the Occurrence and Recurrence of Hepatocellular Carcinoma in Patients with Direct-Acting Antiviral-Induced Sustained Viral Response.

    Itami-Matsumoto S, Hayakawa M, Uchida-Kobayashi S, Enomoto M, Tamori A, Mizuno K, Toyoda H, Tamura T, Akutsu T, Ochiya T, Kawada N, Murakami Y

    Biomedicines   7 ( 4 )   2019.11( ISSN:2227-9059

  • A case series of five patients with hepatic sarcoidosis diagnosed by liver biopsy

    Sho Mitsuhiro, Enomoto Masaru, Kotani Kohei, Odagiri Naoshi, Yoshida Kanako, Motoyama Hiroyuki, Kozuka Ritsuzo, Fujii Hideki, Hagihara Atsushi, Uchida-Kobayashi Sawako, Morikawa Hiroyasu, Murakami Yoshiki, Tamori Akihiro, Kawada Norifumi

    Kanzo   60 ( 11 )   405 - 413   2019.11( ISSN:04514203

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    <p>Sarcoidosis is typically characterized by the presence of lesions in the lungs, heart, eyes, and skin. However, in some cases, lesions have also been found in the liver. Although the diagnosis of hepatic sarcoidosis is difficult, liver biopsy can occasionally offer a definite diagnosis when blood test results indicate liver dysfunction of an unknown etiology. We encountered five cases of hepatic sarcoidosis at our hospital that were diagnosed based on liver dysfunction and compared these cases with previously reported cases. In our case series, hepatic sarcoidosis was predominantly diagnosed in middle-aged women, and biliary enzymes were elevated in most cases. Corticosteroids, ursodeoxycholic acid, or both were used for treatment. Despite the application of these therapies, some patients progressed to showing cirrhosis or even died. Thus, in cases with severe hepatitis, steroid therapy may not be effective and cirrhosis may develop. Moreover, the findings suggest that ursodeoxycholic acid can help in delaying the progression of hepatic sarcoidosis.</p>

    DOI: 10.2957/kanzo.60.405

    CiNii Article

  • 肝機能障害を契機に診断されたサルコイドーシス5例の検討 Reviewed

    焦 光裕, 榎本 大, 小谷 晃平, 小田桐 直志, 吉田 香奈子, 元山 宏行, 小塚 立蔵, 藤井 英樹, 萩原 淳司, 打田 佐和子, 森川 浩安, 村上 善基, 田守 昭博, 河田 則文

    (一社)日本肝臓学会 肝臓   60 ( 11 )   405 - 413   2019.11( ISSN:0451-4203

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    サルコイドーシスは肺、心臓、眼、皮膚等に病変が見られることが多いが、肝臓に病変を有する症例も存在する。肝サルコイドーシスの診断はしばしば難渋することが多いが、肝機能障害が契機となり、確定診断には肝生検が有用である。今回、当院にて肝機能障害を契機に診断されたサルコイドーシスの5例を既報例と併せて検討した。頻度は中年女性に多く、多くの症例でALP異常優位の肝機能障害を認めた。治療としてステロイドやウルソデオキシコール酸が用いられたが、肝硬変へ進展し死亡する症例も認められた。組織学的に炎症が強い場合、ステロイド投与にも関わらず肝硬変へ進展する症例がある。またウルソデオキシコール酸には病状の進行を遅延させる可能性が示唆されている。(著者抄録)

  • 肝機能障害を契機に診断されたサルコイドーシス5例の検討

    焦 光裕, 榎本 大, 小谷 晃平, 小田桐 直志, 吉田 香奈子, 元山 宏行, 小塚 立蔵, 藤井 英樹, 萩原 淳司, 打田 佐和子, 森川 浩安, 村上 善基, 田守 昭博, 河田 則文

    肝臓   60 ( 11 )   405 - 413   2019.11( ISSN:0451-4203

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    サルコイドーシスは肺、心臓、眼、皮膚等に病変が見られることが多いが、肝臓に病変を有する症例も存在する。肝サルコイドーシスの診断はしばしば難渋することが多いが、肝機能障害が契機となり、確定診断には肝生検が有用である。今回、当院にて肝機能障害を契機に診断されたサルコイドーシスの5例を既報例と併せて検討した。頻度は中年女性に多く、多くの症例でALP異常優位の肝機能障害を認めた。治療としてステロイドやウルソデオキシコール酸が用いられたが、肝硬変へ進展し死亡する症例も認められた。組織学的に炎症が強い場合、ステロイド投与にも関わらず肝硬変へ進展する症例がある。またウルソデオキシコール酸には病状の進行を遅延させる可能性が示唆されている。(著者抄録)

  • Cure with Interferon Free DAA is Associated with Increased Survival in Patients with HCV related HCC from both East and West. Reviewed

    Dang H, Yeo YH, Yasuda S, Huang CF, Iio E, Landis C, Jun DW, Enomoto M, Ogawa E, Tsai PC, Le A, Liu M, Maeda M, Nguyen B, Ramrakhiani N, Henry L, Cheung R, Tamori A, Kumada T, Tanaka Y, Yu ML, Toyoda H, Nguyen MH

    Hepatology (Baltimore, Md.)   2019.10( ISSN:0270-9139

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    DOI: 10.1002/hep.30988

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  • Direct-acting antivirals in East Asian hepatitis C patients: real-world experience from the REAL-C Consortium Reviewed

    Huang Chung-Feng, Iio Etsuko, Jun Dae Won, Ogawa Eiichi, Toyoda Hidenori, Hsu Yao-Chun, Haga Hiroaki, Iwane Shinji, Enomoto Masaru, Lee Dong Hyun, Wong Grace, Liu Chen-Hua, Tada Toshifumi, Chuang Wan-Long, Cheung Ramsey, Hayashi Jun, Tseng Cheng-Hao, Yasuda Satoshi, Tran Sally, Kam Leslie, Henry Linda, Jeong Jae Yoon, Nomura Hideyuki, Park Seung Ha, Nakamuta Makoto, Huang Jee-Fu, Tai Chi-Ming, Lo Gin-Ho, Lee Mei-Hsuan, Yang Hwai-I, Kao Jia-Horng, Tamori Akihiro, Eguchi Yuichiro, Ueno Yoshiyuki, Furusyo Norihiro, Tanaka Yasuhito, Yu Ming-Lung, Nguyen Mindie H., Ahn Sang Bong, Azuma Koichi, Chen Tzu-Haw, Dai Chia-Yen, Dohmen Kazufumi, Jun Mi Jung, Jung Jang Han, Kajiwara Eiji, Kato Masaki, Kawano Akira, Koyanagi Toshimasa, Ooho Aritsune, Satoh Takeaki, Shimoda Shinji, Song Do Seon, Takahashi Hirokazu, Takahashi Kazuhiro, Tsai Pei-Chien, Tseng Chao-Ming, Yeh Ming-Lun, Yoon Eileen L.

    HEPATOLOGY INTERNATIONAL   13 ( 5 )   587 - 598   2019.09( ISSN:1936-0533

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    DOI: 10.1007/s12072-019-09974-z

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  • Sustained virologic response to direct-acting antiviral therapy in patients with chronic hepatitis C and hepatocellular carcinoma: A systematic review and meta-analysis Reviewed

    Ji Fanpu, Yeo Yee Hui, Wei Mike Tzuhen, Ogawa Eiichi, Enomoto Masaru, Lee Dong Hyun, Iio Etsuko, Lubel John, Wang Wenjun, Wei Bin, Ide Tatsuya, Preda Carmen Monica, Conti Fabio, Minami Tatsuya, Bielen Rob, Sezaki Hitomi, Barone Michele, Kolly Philippe, Chu Po-sung, Virlogeux Victor, Eurich Dennis, Henry Linda, Bass Michelle B., Kanai Takanori, Dang Shuangsuo, Li Zongfang, Dufour Jean-Francois, Zoulim Fabien, Andreone Pietro, Cheung Ramsey C., Tanaka Yasuhito, Furusyo Norihiro, Toyoda Hidenori, Tamori Akihiro, Nguyen Mindie H.

    JOURNAL OF HEPATOLOGY   71 ( 3 )   473 - 485   2019.09( ISSN:0168-8278

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    DOI: 10.1016/j.jhep.2019.04.017

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  • Direct-acting antivirals in East Asian hepatitis C patients: real-world experience from the REAL-C Consortium.

    Huang CF, Iio E, Jun DW, Ogawa E, Toyoda H, Hsu YC, Haga H, Iwane S, Enomoto M, Lee DH, Wong G, Liu CH, Tada T, Chuang WL, Cheung R, Hayashi J, Tseng CH, Yasuda S, Tran S, Kam L, Henry L, Jeong JY, Nomura H, Park SH, Nakamuta M, Huang JF, Tai CM, Lo GH, Lee MH, Yang HI, Kao JH, Tamori A, Eguchi Y, Ueno Y, Furusyo N, Tanaka Y, Yu ML, Nguyen MH, REAL-C Investigators

    Hepatology international   13 ( 5 )   587 - 598   2019.09( ISSN:1936-0533

  • Sustained virologic response to direct-acting antiviral therapy in patients with chronic hepatitis C and hepatocellular carcinoma: A systematic review and meta-analysis.

    Ji F, Yeo YH, Wei MT, Ogawa E, Enomoto M, Lee DH, Iio E, Lubel J, Wang W, Wei B, Ide T, Preda CM, Conti F, Minami T, Bielen R, Sezaki H, Barone M, Kolly P, Chu PS, Virlogeux V, Eurich D, Henry L, Bass MB, Kanai T, Dang S, Li Z, Dufour JF, Zoulim F, Andreone P, Cheung RC, Tanaka Y, Furusyo N, Toyoda H, Tamori A, Nguyen MH

    Journal of hepatology   71 ( 3 )   473 - 485   2019.09( ISSN:0168-8278

  • Interstitial pneumonia suspected during regorafenib administration and exacerbated by subsequent therapy with lenvatinib for unresectable hepatocellular carcinoma Reviewed

    Kotani Kohei, Enomoto Masaru, Okada Masako, Yoshida Kanako, Motoyama Hiroyuki, Fujii Hideki, Hagihara Atsushi, Uchida-Kobayashi Sawako, Morikawa Hiroyasu, Murakami Yoshiki, Tamori Akihiro, Kawada Norifumi

    CLINICAL JOURNAL OF GASTROENTEROLOGY   12 ( 4 )   355 - 360   2019.08( ISSN:1865-7257

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    DOI: 10.1007/s12328-019-00983-x

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  • Interstitial pneumonia suspected during regorafenib administration and exacerbated by subsequent therapy with lenvatinib for unresectable hepatocellular carcinoma.

    Kotani K, Enomoto M, Okada M, Yoshida K, Motoyama H, Fujii H, Hagihara A, Uchida-Kobayashi S, Morikawa H, Murakami Y, Tamori A, Kawada N

    Clinical journal of gastroenterology   12 ( 4 )   355 - 360   2019.08( ISSN:18657257

  • Switching to tenofovir disoproxil fumarate vs continuing treatment in patients with chronic hepatitis B who maintain long-term virological response to entecavir therapy: A randomized trial Reviewed

    Iida-Ueno Ayako, Enomoto Masaru, Kozuka Ritsuzo, Tamori Akihiro, Kawada Norifumi

    JOURNAL OF MEDICAL VIROLOGY   91 ( 7 )   1295 - 1300   2019.07( ISSN:0146-6615

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    DOI: 10.1002/jmv.25442

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  • 非肝臓専門医へのデプスインタビューに基づく当院での「肝炎用診療情報提供書」運用による成果 Reviewed

    井上 貴子, 是永 匡紹, 井上 淳, 本田 浩一, 近藤 泰輝, 的野 智光, 榎本 大, 松波 加代子, 飯尾 悦子, 松浦 健太郎, 藤原 圭, 野尻 俊輔, 田中 靖人

    (一社)日本肝臓学会 肝臓   60 ( 7 )   219 - 228   2019.07( ISSN:0451-4203

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    全国的にB型肝炎患者の専門医への紹介率が低いことが課題である。我々は2017年2月から5月、個人の動機や思考のプロセスを探り出す手法・深層面接法(デプスインタビュー)で、非肝臓専門医に聞き取り調査を行なった。B型肝炎患者を紹介する医師は23名中14名(61%)で、内科系17名中13名(76%)、外科系6名中1名(17%)と差がみられた(p=0.036)。紹介しない理由に診療情報提供書を書く時間の不足・紹介方法の不識を、紹介率向上への工夫として診療情報提供書の簡素化・平易な診療予約制度をあげる医師が多かった。この結果から当院では同年8月、短時間で記載できる「肝炎用診療情報提供書」の運用を開始した。導入後、B型肝炎に限らずC型肝炎・その他も含めた肝疾患全体の紹介患者数は前年比1.6倍に増加した。厚生労働省研究班で水平展開を試みており、データ蓄積からより効率的なシステムの構築が期待できる。(著者抄録)

  • Switching to tenofovir disoproxil fumarate vs continuing treatment in patients with chronic hepatitis B who maintain long-term virological response to entecavir therapy: A randomized trial.

    Iida-Ueno A, Enomoto M, Kozuka R, Tamori A, Kawada N

    Journal of medical virology   91 ( 7 )   1295 - 1300   2019.07( ISSN:0146-6615

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  • 非肝臓専門医へのデプスインタビューに基づく当院での「肝炎用診療情報提供書」運用による成果

    井上 貴子, 是永 匡紹, 井上 淳, 本田 浩一, 近藤 泰輝, 的野 智光, 榎本 大, 松波 加代子, 飯尾 悦子, 松浦 健太郎, 藤原 圭, 野尻 俊輔, 田中 靖人

    肝臓   60 ( 7 )   219 - 228   2019.07( ISSN:0451-4203

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    全国的にB型肝炎患者の専門医への紹介率が低いことが課題である。我々は2017年2月から5月、個人の動機や思考のプロセスを探り出す手法・深層面接法(デプスインタビュー)で、非肝臓専門医に聞き取り調査を行なった。B型肝炎患者を紹介する医師は23名中14名(61%)で、内科系17名中13名(76%)、外科系6名中1名(17%)と差がみられた(p=0.036)。紹介しない理由に診療情報提供書を書く時間の不足・紹介方法の不識を、紹介率向上への工夫として診療情報提供書の簡素化・平易な診療予約制度をあげる医師が多かった。この結果から当院では同年8月、短時間で記載できる「肝炎用診療情報提供書」の運用を開始した。導入後、B型肝炎に限らずC型肝炎・その他も含めた肝疾患全体の紹介患者数は前年比1.6倍に増加した。厚生労働省研究班で水平展開を試みており、データ蓄積からより効率的なシステムの構築が期待できる。(著者抄録)

  • Successful direct-acting antiviral treatment of three patients with genotype 2/1 recombinant hepatitis C virus Reviewed

    Okada Masako, Hai Hoang, Tamori Akihiro, Uchida-Kobayashi Sawako, Enomoto Masaru, Kumada Hiromitsu, Kawada Norifumi

    CLINICAL JOURNAL OF GASTROENTEROLOGY   12 ( 3 )   213 - 217   2019.06( ISSN:1865-7257

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    DOI: 10.1007/s12328-018-0922-9

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  • ジェノタイプ2/1組み換えC型肝炎ウイルス感染患者3例に対して奏効した直接作用型抗ウイルス剤投与(Successful direct-acting antiviral treatment of three patients with genotype 2/1 recombinant hepatitis C virus) Reviewed

    Okada Masako, Hai Hoang, Tamori Akihiro, Uchida-Kobayashi Sawako, Enomoto Masaru, Kumada Hiromitsu, Kawada Norifumi

    シュプリンガー・ジャパン(株) Clinical Journal of Gastroenterology   12 ( 3 )   213 - 217   2019.06( ISSN:1865-7257

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    直接作用型抗ウイルス剤(DAA)投与が奏効したジェノタイプ2/1組み換えC型肝炎ウイルス(HCV)患者3例を報告した。症例1は39歳男性で、慢性C型肝炎に対しインターフェロンベースの治療を行ったが無効であった。当院に紹介され、組み換えHCVジェノタイプ2a/1bへの感染を認めた。再燃ウイルスはキメラHCV2a/1bであり、組み換えブレイクポイントはNS3領域開始のヌクレオチド+49に認めた。グラゾプレビルとエルバスビルを投与したところ、持続性ウイルス学的著効(SVR)に至った。症例2は70歳女性で、組み換えHCVジェノタイプ2b/1bに感染し、ソホスブビルとレジパスビルによるDAA療法によりSVRを得た。症例3は48歳女性で、組み換えHCVジェノタイプ2b/1bに感染し、ダクラタスビルとアスナプレビルによるDAA治療を実施しSVRに至った。症例2と症例3からのウイルスのベースライン配列は組み換えブレイクポイントがNS3からヌクレオチド+10のキメラHCV 2b/1bを示した。

  • Successful direct-acting antiviral treatment of three patients with genotype 2/1 recombinant hepatitis C virus.

    Okada M, Hai H, Tamori A, Uchida-Kobayashi S, Enomoto M, Kumada H, Kawada N

    Clinical journal of gastroenterology   12 ( 3 )   213 - 217   2019.06( ISSN:18657257

  • 特集 肝臓病学の未来-ウイルス性肝炎から脂肪肝と肝がんの時代へ C型肝炎 HCV排除は肝がんを抑制するのか:外来でのフォローはどうするか

    榎本 大, 伊倉 義弘, 田守 昭博, 河田 則文

    内科   123 ( 5 )   1081 - 1085   2019.05( ISSN:00221961

  • Association between HLA-DQA1/DRB1 polymorphism and development of hepatocellular carcinoma during entecavir treatment Reviewed

    Kozuka Ritsuzo, Enomoto Masaru, Sato-Matsubara Misako, Yoshida Kanako, Motoyama Hiroyuki, Hagihara Atsushi, Fujii Hideki, Uchida-Kobayashi Sawako, Morikawa Hiroyasu, Tamori Akihiro, Kawada Norifumi, Murakami Yoshiki

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   34 ( 5 )   937 - 946   2019.05( ISSN:0815-9319

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    DOI: 10.1111/jgh.14454

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  • Changes in plasma interleukin-8 and tumor necrosis factor-alpha levels during the early treatment period as a predictor of the response to sorafenib in patients with unresectable hepatocellular carcinoma Reviewed

    Iida-Ueno Ayako, Enomoto Masaru, Uchida-Kobayashi Sawako, Hagihara Atsushi, Teranishi Yuga, Fujii Hideki, Morikawa Hiroyasu, Murakami Yoshiki, Tamori Akihiro, Le Thi Thanh Thuy, Kawada Norifumi

    CANCER CHEMOTHERAPY AND PHARMACOLOGY   82 ( 5 )   857 - 864   2018.11( ISSN:0344-5704

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    DOI: 10.1007/s00280-018-3681-x

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  • Short-term histological evaluations after achieving a sustained virologic response to direct-acting antiviral treatment for chronic hepatitis C Reviewed

    Enomoto Masaru, Ikura Yoshihiro, Tamori Akihiro, Kozuka Ritsuzo, Motoyama Hiroyuki, Kawamura Etsushi, Hagihara Atsushi, Fujii Hideki, Uchida-Kobayashi Sawako, Morikawa Hiroyasu, Murakami Yoshiki, Kawada Norifumi

    UNITED EUROPEAN GASTROENTEROLOGY JOURNAL   6 ( 9 )   1391 - 1400   2018.11( ISSN:2050-6406

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    DOI: 10.1177/2050640618791053

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  • Short-term histological evaluations after achieving a sustained virologic response to direct-acting antiviral treatment for chronic hepatitis C.

    Enomoto M, Ikura Y, Tamori A, Kozuka R, Motoyama H, Kawamura E, Hagihara A, Fujii H, Uchida-Kobayashi S, Morikawa H, Murakami Y, Kawada N

    United European gastroenterology journal   6 ( 9 )   1391 - 1400   2018.11( ISSN:2050-6406

  • A Clinical Quantitative Evaluation of Hepatobiliary Transport of [C-11] Dehydropravastatin in Humans Using Positron Emission Tomography Reviewed

    Kaneko Ken-Ichi, Tanaka Masaaki, Ishii Akira, Katayama Yumiko, Nakaoka Takayoshi, Irie Satsuki, Kawahata Hideki, Yamanaga Takashi, Wada Yasuhiro, Miyake Takeshi, Toshimoto Kota, Maeda Kazuya, Cui Yilong, Enomoto Masaru, Kawamura Etsushi, Kawada Norifumi, Kawabe Joji, Shiomi Susumu, Kusuhara Hiroyuki, Sugiyama Yuichi, Watanabe Yasuyoshi

    DRUG METABOLISM AND DISPOSITION   46 ( 5 )   719 - 728   2018.05( ISSN:0090-9556

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    DOI: 10.1124/dmd.118.080408

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  • Low incidence of hepatitis B virus reactivation and subsequent hepatitis in patients with chronic hepatitis C receiving direct-acting antiviral therapy Reviewed

    Tamori A., Abiru S., Enomoto H., Kioka K., Korenaga M., Tani J., Enomoto M., Sugiyama M., Masaki T., Kawada N., Yatsuhashi H., Nishiguchi S., Mizokami M.

    JOURNAL OF VIRAL HEPATITIS   25 ( 5 )   608 - 611   2018.05( ISSN:1352-0504

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    DOI: 10.1111/jvh.12840

  • The presence of multiple NS5A RASs is associated with the outcome of sofosbuvir and ledipasvir therapy in NS5A inhibitor-naive patients with chronic HCV genotype 1b infection in a real-world cohort Reviewed

    Kozuka R., Hai H., Motoyama H., Hagihara A., Fujii H., Uchida-Kobayashi S., Morikawa H., Enomoto M., Murakami Y., Kawada N., Tamori A.

    JOURNAL OF VIRAL HEPATITIS   25 ( 5 )   535 - 542   2018.05( ISSN:1352-0504

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    DOI: 10.1111/jvh.12850

  • The presence of multiple NS5A RASs is associated with the outcome of sofosbuvir and ledipasvir therapy in NS5A inhibitor-naïve patients with chronic HCV genotype 1b infection in a real-world cohort.

    Kozuka R, Hai H, Motoyama H, Hagihara A, Fujii H, Uchida-Kobayashi S, Morikawa H, Enomoto M, Murakami Y, Kawada N, Tamori A

    Journal of viral hepatitis   25 ( 5 )   535 - 542   2018.05( ISSN:1352-0504

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  • Sequential therapy involving an early switch from entecavir to pegylated interferon-α in Japanese patients with chronic hepatitis B.

    Enomoto M, Nishiguchi S, Tamori A, Kozuka R, Fujii H, Uchida-Kobayashi S, Fukunishi S, Tsuda Y, Higuchi K, Saito M, Enomoto H, Kawada N

    Hepatology research : the official journal of the Japan Society of Hepatology   48 ( 6 )   459 - 468   2018.05( ISSN:1386-6346

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  • Low incidence of hepatitis B virus reactivation and subsequent hepatitis in patients with chronic hepatitis C receiving direct-acting antiviral therapy.

    Tamori A, Abiru S, Enomoto H, Kioka K, Korenaga M, Tani J, Enomoto M, Sugiyama M, Masaki T, Kawada N, Yatsuhashi H, Nishiguchi S, Mizokami M

    Journal of viral hepatitis   25 ( 5 )   608 - 611   2018.05( ISSN:1352-0504

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  • Stagnation of histopathological improvement is a predictor of hepatocellular carcinoma development after hepatitis C virus eradication Reviewed

    Motoyama Hiroyuki, Tamori Akihiro, Kubo Shoji, Uchida-Kobayashi Sawako, Takemura Shigekazu, Tanaka Shogo, Ohfuji Satoko, Teranishi Yuga, Kozuka Ritsuzo, Kawamura Etsushi, Hagihara Atsushi, Morikawa Hiroyasu, Enomoto Masaru, Murakami Yoshiki, Kawada Norifumi

    PLOS ONE   13 ( 3 )   e0194163   2018.03( ISSN:1932-6203

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    DOI: 10.1371/journal.pone.0194163

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  • Combinational use of hepatitis B viral antigens predicts responses to nucleos(t)ide analogue/peg-interferon sequential therapy Reviewed

    Matsumoto Akihiro, Nishiguchi Shuhei, Enomoto Hirayuki, Kang Jong-Hon, Tanaka Yasuhito, Shinkai Noboru, Kurosaki Masayuki, Enomoto Masaru, Kanda Tatsuo, Yokosuka Osamu, Yatsuhashi Hiroshi, Nagaoka Shinya, Okuse Chiaki, Kagawa Tatehiro, Mine Tetsuya, Takaguchi Koichi, Saito Satoru, Hino Keisuke, Ikeda Fusao, Sakisaka Shotaro, Morihara Daisuke, Miyase Shiho, Tsuge Masataka, Chayama Kazuaki, Hiramatsu Naoki, Suzuki Yoshiyuki, Murata Kazumoto, Tanaka Eiji

    JOURNAL OF GASTROENTEROLOGY   53 ( 2 )   247 - 257   2018.02( ISSN:0944-1174

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    DOI: 10.1007/s00535-017-1360-z

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  • Remission of Psoriasis After Treatment of Chronic Hepatitis C Virus Infection With Direct-Acting Antivirals. Reviewed

    Enomoto M, Tateishi C, Tsuruta D, Tamori A, Kawada N

    Annals of internal medicine   2018.01( ISSN:0003-4819

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    DOI: 10.7326/L17-0613

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  • Sequential therapy involving an early switch from entecavir to pegylated interferon-α in Japanese patients with chronic hepatitis B. Reviewed

    Enomoto M, Nishiguchi S, Tamori A, Kozuka R, Fujii H, Uchida-Kobayashi S, Fukunishi S, Tsuda Y, Higuchi K, Saito M, Enomoto H, Kawada N

    Hepatology research : the official journal of the Japan Society of Hepatology   2018.01( ISSN:1386-6346

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/hepr.13050

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  • Polymorphisms in MICA, but not in DEPDC5, HCP5 or PNPLA3, are associated with chronic hepatitis C-related hepatocellular carcinoma Reviewed

    Hai Hoang, Tamori Akihiro, Le Thi Thanh Thuy, Yoshida Kanako, Hagihara Atsushi, Kawamura Etsushi, Uchida-Kobayashi Sawako, Morikawa Hiroyasu, Enomoto Masaru, Murakami Yoshiki, Kawada Norifumi

    SCIENTIFIC REPORTS   7 ( 1 )   11912   2017.09( ISSN:2045-2322

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    DOI: 10.1038/s41598-017-10363-5

    PubMed

  • Direct-acting antivirals治療例におけるC型肝炎ウイルス感染経路の検討 再感染リスクを踏まえて Reviewed

    湯川 芳美, 田守 昭博, 寺西 優雅, 元山 宏行, 小塚 立蔵, 川村 悦史, 萩原 淳司, 打田 佐和子[小林], 森川 浩安, 榎本 大, 村上 善基, 福島 若葉, 河田 則文

    (一社)日本肝臓学会 肝臓   58 ( 8 )   435 - 440   2017.08( ISSN:0451-4203

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    当院で2014年9月から2016年8月までに直接作用型抗ウイルス薬治療を施行したC型慢性肝疾患患者616例及び2007年5月以降に経験したC型急性肝炎患者8例に対し、感染経路の実態を調査し再感染の可能性について検討した。616例のうち感染経路を推定しえた症例は372例(60.4%)であり、その内訳は輸血歴/手術歴/薬物使用歴/家族歴/刺青:189/279/30/18/24例(51.3%/75.8%/8.2%/4.9%/6.5%)であった(重複回答含む)。薬物使用歴、刺青を有する患者の特徴として若年、男性、genotype 2があげられた。また、外来治療を自己中断した症例の特徴も同様に若年、男性、genotype 2であった。観察期間内に再感染例はみられなかったが、今後再感染を予防する上で、これらに対する慎重な経過観察と患者教育が重要な課題である。(著者抄録)

  • Correlation between polymorphism in the inosine triphosphatase and the reductions in hemoglobin concentration and ribavirin dose during sofosbuvir and ribavirin therapy Reviewed

    Kozuka Ritsuzo, Hai Hoang, Teranishi Yuga, Motoyama Hiroyuki, Kawamura Etsushi, Hagihara Atsushi, Uchida-Kobayashi Sawako, Morikawa Hiroyasu, Enomoto Masaru, Murakami Yoshiki, Kawada Norifumi, Tamori Akihiro

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   32 ( 8 )   1495 - 1502   2017.08( ISSN:0815-9319

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    DOI: 10.1111/jgh.13743

    PubMed

  • Direct-acting antivirals治療例におけるC型肝炎ウイルス感染経路の検討 再感染リスクを踏まえて

    湯川 芳美, 田守 昭博, 寺西 優雅, 元山 宏行, 小塚 立蔵, 川村 悦史, 萩原 淳司, 打田 佐和子[小林], 森川 浩安, 榎本 大, 村上 善基, 福島 若葉, 河田 則文

    肝臓   58 ( 8 )   435 - 440   2017.08( ISSN:0451-4203

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    当院で2014年9月から2016年8月までに直接作用型抗ウイルス薬治療を施行したC型慢性肝疾患患者616例及び2007年5月以降に経験したC型急性肝炎患者8例に対し、感染経路の実態を調査し再感染の可能性について検討した。616例のうち感染経路を推定しえた症例は372例(60.4%)であり、その内訳は輸血歴/手術歴/薬物使用歴/家族歴/刺青:189/279/30/18/24例(51.3%/75.8%/8.2%/4.9%/6.5%)であった(重複回答含む)。薬物使用歴、刺青を有する患者の特徴として若年、男性、genotype 2があげられた。また、外来治療を自己中断した症例の特徴も同様に若年、男性、genotype 2であった。観察期間内に再感染例はみられなかったが、今後再感染を予防する上で、これらに対する慎重な経過観察と患者教育が重要な課題である。(著者抄録)

  • Detection of HCV RNA in Sustained Virologic Response to Direct-Acting Antiviral Agents: Occult or Science Fiction? Reviewed

    Enomoto Masaru, Murakami Yoshiki, Kawada Norifumi

    GASTROENTEROLOGY   153 ( 1 )   327 - 328   2017.07( ISSN:0016-5085

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    DOI: 10.1053/j.gastro.2017.03.075

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  • Long-Term Follow-Up of Resistance-Associated Substitutions in Hepatitis C Virus in Patients in Which Direct Acting Antiviral-Based Therapy Failed Reviewed

    Yoshida Kanako, Hai Hoang, Tamori Akihiro, Teranishi Yuga, Kozuka Ritsuzo, Motoyama Hiroyuki, Kawamura Etsushi, Hagihara Atsushi, Uchida-Kobayashi Sawako, Morikawa Hiroyasu, Enomoto Masaru, Murakami Yoshiki, Kawada Norifumi

    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES   18 ( 5 )   2017.05

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    DOI: 10.3390/ijms18050962

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  • Hepatitis B virus infection and alcohol consumption Reviewed

    Iida-Ueno Ayako, Enomoto Masaru, Tamori Akihiro, Kawada Norifumi

    WORLD JOURNAL OF GASTROENTEROLOGY   23 ( 15 )   2651 - 2659   2017.04( ISSN:1007-9327

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    DOI: 10.3748/wjg.v23.i15.2651

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  • Effects of antiviral therapy in patients with chronic hepatitis B and cirrhosis Reviewed

    Okada Masako, Enomoto Masaru, Kawada Norifumi, Nguyen Mindie H.

    EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY   11 ( 12 )   1095 - 1104   2017( ISSN:1747-4124

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    DOI: 10.1080/17474124.2017.1361822

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  • Outcomes for Cirrhotic Patients with Hepatitis C Virus 1b Treated with Asunaprevir and Daclatasvir Combination Reviewed

    Tamori Akihiro, Hai Hoang, Uchida-Kobayashi Sawako, Enomoto Masaru, Kozuka Ritsuzo, Motoyama Hiroyuki, Kawamura Etsushi, Hagihara Atsushi, Teranishi Yuga, Yoshida Kanako, Morikawa Hiroyasu, Murakami Yoshiki, Kawada Norifumi

    ANNALS OF HEPATOLOGY   16 ( 5 )   734 - 741   2017( ISSN:1665-2681

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    DOI: 10.5604/01.3001.0010.2732

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  • Advances in antiviral therapy for chronic hepatitis C and portal hypertension

    Enomoto M, Kawada N

    Japanese Journal of Portal Hypertension   23 ( 2 )   149 - 154   2017( ISSN:13448447

  • Randomized trial of combined triple therapy comprising two types of peginterferon with simeprevir in patients with hepatitis C virus genotype 1b Reviewed

    Tamori Akihiro, Yoshida Kanako, Kurai Osamu, Kioka Kiyohide, Hai Hoang, Kozuka Ritsuzo, Motoyama Hiroyuki, Kawamura Etsushi, Hagihara Atsushi, Uchida-Kobayashi Sawako, Morikawa Hiroyasu, Enomoto Masaru, Murakami Yoshiki, Kawada Norifumi

    HEPATOLOGY RESEARCH   46 ( 13 )   1311 - 1320   2016.12( ISSN:1386-6346

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    DOI: 10.1111/hepr.12689

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  • Putting "sticky notes" on the electronic medical record to promote intra-hospital referral of hepatitis B and C virus-positive patients to hepatology specialists: an exploratory study Reviewed

    Fujii Hideki, Yamaguchi Seiko, Kurai Osamu, Miyano Masato, Ueda Wataru, Oba Hiroko, Aoki Tetsuya, Enomoto Masaru, Kawada Norifumi, Okawa Kiyotaka

    BMC INFECTIOUS DISEASES   16   410   2016.08( ISSN:1471-2334

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s12879-016-1765-y

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  • ダクラタスビル/アスナプレビル治療が著効したクリオグロブリン血管炎合併C型慢性肝疾患の一例 Reviewed

    高田 さゆり, 打田 佐和子[小林], 飯田 綾子[上野], 寺西 優雅, 元山 宏行, 小塚 立蔵, 川村 悦史, 萩原 淳司, 石津 弘隆, 森川 浩安, 榎本 大, 村上 善基, 田守 昭博, 河田 則文

    (一社)日本肝臓学会 肝臓   57 ( 7 )   328 - 333   2016.07( ISSN:0451-4203

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    症例は72歳女性。C型慢性肝炎(Genotype 1b)に対して、過去にインターフェロン療法を受けたが無効であった。2014年9月(71歳時)に、発熱、下腿浮腫、紫斑を呈し、C型肝炎ウイルス(hepatitis C virus:HCV)関連クリオグロブリン血管炎と診断された。ダクラタスビル(daclatasvir;DCV)、アスナプレビル(asunaprevir;ASV)による抗ウイルス療法を導入したところHCV量の低下とともに血管炎は著明に改善した。患者はウイルス学的著効となり血管炎の再燃はない。近年、多くのdirect acting antiviral agentsが開発されているが、クリオグロブリン血管炎を合併したC型慢性肝炎例に対してDCV/ASVによる治療を行った報告はなく、今後のHCV関連クリオグロブリン血管炎の治療選択肢の一つになると考えるため報告する。(著者抄録)

  • ダクラタスビル/アスナプレビル治療が著効したクリオグロブリン血管炎合併C型慢性肝疾患の一例

    高田 さゆり, 打田 佐和子[小林], 飯田 綾子[上野], 寺西 優雅, 元山 宏行, 小塚 立蔵, 川村 悦史, 萩原 淳司, 石津 弘隆, 森川 浩安, 榎本 大, 村上 善基, 田守 昭博, 河田 則文

    肝臓   57 ( 7 )   328 - 333   2016.07( ISSN:0451-4203

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    症例は72歳女性。C型慢性肝炎(Genotype 1b)に対して、過去にインターフェロン療法を受けたが無効であった。2014年9月(71歳時)に、発熱、下腿浮腫、紫斑を呈し、C型肝炎ウイルス(hepatitis C virus:HCV)関連クリオグロブリン血管炎と診断された。ダクラタスビル(daclatasvir;DCV)、アスナプレビル(asunaprevir;ASV)による抗ウイルス療法を導入したところHCV量の低下とともに血管炎は著明に改善した。患者はウイルス学的著効となり血管炎の再燃はない。近年、多くのdirect acting antiviral agentsが開発されているが、クリオグロブリン血管炎を合併したC型慢性肝炎例に対してDCV/ASVによる治療を行った報告はなく、今後のHCV関連クリオグロブリン血管炎の治療選択肢の一つになると考えるため報告する。(著者抄録)

  • MicroRNA expression in hepatocellular carcinoma after the eradication of chronic hepatitis virus C infection using interferon therapy Reviewed

    Tamori Akihiro, Murakami Yoshiki, Kubo Shoji, Itami Saori, Uchida-Kobayashi Sawako, Morikawa Hiroyasu, Enomoto Masaru, Takemura Shigekazu, Tanahashi Toshihito, Taguchi Y-h., Kawada Norifumi

    HEPATOLOGY RESEARCH   46 ( 3 )   E26 - E35   2016.03( ISSN:1386-6346

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    DOI: 10.1111/hepr.12518

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  • 当院における肝炎ウイルス検査の実施状況と陽性者に対する受診勧奨システム構築による院内連携の変化について Reviewed

    打田 佐和子[小林], 榎本 大, 藤井 英樹, 飯田 綾子[上野], 元山 宏行, 小塚 立蔵, 萩原 淳司, 川村 悦史, 森川 浩安, 村上 善基, 田守 昭博, 河田 則文

    (一社)日本肝臓学会 肝臓   57 ( 1 )   7 - 16   2016.01( ISSN:0451-4203

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    感染症スクリーニング検査で判明した肝炎ウイルス感染者が適切に院内連携できているかは明らかではない。当院では2013年4月からHBs抗原またはHCV抗体陽性者に関して電子カルテ上で専門科である肝胆膵内科への紹介を促す新たなシステムを構築した。また術前診察マニュアルを変更して麻酔科外来でも肝胆膵内科への紹介を促すようにした。当院における2012年度(新システム開始前)のHBs抗原検査数は13,004件、HCV抗体検査数は12,374件であった。陽性者はそれぞれ450例、711例で、ともに肝胆膵内科が最多であったが、整形外科、眼科、耳鼻科など外科系診療科がこれに次いだ。新システム開始後、肝炎ウイルス関連の院内紹介数は、18.8±5.7例/月から28.7±4.6例/月へと増加し、耳鼻科、眼科、整形外科など陽性者が多い診療科から確実に紹介されていた。新システムによる肝炎ウイルス感染者の拾い上げは、円滑な院内連携、陽性患者の専門医によるフォローアップや治療につながることが期待される。(著者抄録)

  • 当院における肝炎ウイルス検査の実施状況と陽性者に対する受診勧奨システム構築による院内連携の変化について

    打田 佐和子[小林], 榎本 大, 藤井 英樹, 飯田 綾子[上野], 元山 宏行, 小塚 立蔵, 萩原 淳司, 川村 悦史, 森川 浩安, 村上 善基, 田守 昭博, 河田 則文

    肝臓   57 ( 1 )   7 - 16   2016.01( ISSN:0451-4203

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    感染症スクリーニング検査で判明した肝炎ウイルス感染者が適切に院内連携できているかは明らかではない。当院では2013年4月からHBs抗原またはHCV抗体陽性者に関して電子カルテ上で専門科である肝胆膵内科への紹介を促す新たなシステムを構築した。また術前診察マニュアルを変更して麻酔科外来でも肝胆膵内科への紹介を促すようにした。当院における2012年度(新システム開始前)のHBs抗原検査数は13,004件、HCV抗体検査数は12,374件であった。陽性者はそれぞれ450例、711例で、ともに肝胆膵内科が最多であったが、整形外科、眼科、耳鼻科など外科系診療科がこれに次いだ。新システム開始後、肝炎ウイルス関連の院内紹介数は、18.8±5.7例/月から28.7±4.6例/月へと増加し、耳鼻科、眼科、整形外科など陽性者が多い診療科から確実に紹介されていた。新システムによる肝炎ウイルス感染者の拾い上げは、円滑な院内連携、陽性患者の専門医によるフォローアップや治療につながることが期待される。(著者抄録)

  • Recent Advances in Antiviral Therapy for Chronic Hepatitis C Reviewed

    Tamori Akihiro, Enomoto Masaru, Kawada Norifumi

    MEDIATORS OF INFLAMMATION   2016   6841628   2016( ISSN:0962-9351

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    DOI: 10.1155/2016/6841628

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  • Development of novel hepatitis B virus capsid inhibitor using in silico screening Reviewed

    Hayakawa Michiyo, Umeyama Hideaki, Iwadate Mitsuo, Tanahashi Toshihito, Yano Yoshihiko, Enomoto Masaru, Tamori Akihiro, Kawada Norifumi, Murakami Yoshiki

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   463 ( 4 )   1165 - 1175   2015.08( ISSN:0006-291X

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    DOI: 10.1016/j.bbrc.2015.06.077

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  • Long-Term Outcome of Sequential Therapy with Lamivudine Followed by Interferon-beta in Nucleoside-Naive, Hepatitis B e-Antigen-Positive Patients with Chronic Hepatitis B Virus Genotype C Infection Reviewed

    Enomoto Masaru, Nishiguchi Shuhei, Tamori Akihiro, Kozuka Ritsuzo, Hayashi Takehiro, Kohmoto Madoka Toyama, Jomura Hisato, Morikawa Hiroyasu, Murakami Yoshiki, Shiomi Susumu, Kawada Norifumi

    JOURNAL OF INTERFERON AND CYTOKINE RESEARCH   35 ( 8 )   613 - 620   2015.08( ISSN:1079-9907

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    DOI: 10.1089/jir.2014.0234

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  • Discovering novel direct acting antiviral agents for HBV using in silico screening Reviewed

    Murakami Yoshiki, Hayakawa Michiyo, Yano Yoshihiko, Tanahashi Toshihito, Enomoto Masaru, Tamori Akihiro, Kawada Norifumi, Iwadate Mitsuo, Umeyama Hideaki

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   456 ( 1 )   20 - 28   2015.01( ISSN:0006-291X

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    DOI: 10.1016/j.bbrc.2014.11.024

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  • Effects on anemia of drug adjustment in patients with chronic hepatitis C during telaprevir-combined therapy. Reviewed

    Tamori A, Kioka K, Sakaguchi H, Enomoto M, Hai H, Kawamura E, Hagihara A, Fujii H, Uchida-Kobayashi S, Iwai S, Morikawa H, Murakami Y, Kawasaki Y, Tsuruta D, Kawada N

    Annals of hepatology   14 ( 1 )   28 - 35   2015.01( ISSN:1665-2681

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    PubMed

  • Effects on anemia of drug adjustment in patients with chronic hepatitis C during telaprevir-combined therapy.

    Tamori A, Kioka K, Sakaguchi H, Enomoto M, Hai H, Kawamura E, Hagihara A, Fujii H, Uchida-Kobayashi S, Iwai S, Morikawa H, Murakami Y, Kawasaki Y, Tsuruta D, Kawada N

    Annals of hepatology   14 ( 1 )   28 - 35   2015.01( ISSN:1665-2681

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  • Adjuvant epoetin-beta with peginterferon-alpha and ribavirin in Japanese ribavirin-intolerant relapsed patients with chronic hepatitis C genotype 2 Reviewed

    Enomoto Masaru, Morikawa Hiroyasu, Murakami Yoshiki, Tamori Akihiro, Kawada Norifumi

    HEPATOLOGY RESEARCH   44 ( 10 )   E290 - E296   2014.10( ISSN:1386-6346

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    DOI: 10.1111/hepr.12257

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  • Noninvasive assessment of liver fibrosis in patients with chronic hepatitis B Reviewed

    Enomoto Masaru, Morikawa Hiroyasu, Tamori Akihiro, Kawada Norifumi

    WORLD JOURNAL OF GASTROENTEROLOGY   20 ( 34 )   12031 - 12038   2014.09( ISSN:1007-9327

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    DOI: 10.3748/wjg.v20.i34.12031

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  • Comparison of Hepatocellular Carcinoma miRNA Expression Profiling as Evaluated by Next Generation Sequencing and Microarray Reviewed

    Murakami Yoshiki, Tanahashi Toshihito, Okada Rina, Toyoda Hidenori, Kumada Takashi, Enomoto Masaru, Tamori Akihiro, Kawada Norifumi, Taguchi Y-h, Azuma Takeshi

    PLOS ONE   9 ( 9 )   e106314   2014.09( ISSN:1932-6203

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    DOI: 10.1371/journal.pone.0106314

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  • Prospective long-term study of hepatitis B virus reactivation in patients with hematologic malignancy Reviewed

    Tamori Akihiro, Hino Masayuki, Kawamura Etsushi, Fujii Hideki, Uchida-Kobayashi Sawako, Morikawa Hiroyasu, Nakamae Hirohisa, Enomoto Masaru, Murakami Yoshiki, Kawada Norifumi

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   29 ( 9 )   1715 - 1721   2014.09( ISSN:0815-9319

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    DOI: 10.1111/jgh.12604

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  • Interferon-alpha/beta for treatment of chronic hepatitis C infection in the era of direct-acting antiviral agents Reviewed

    Enomoto Masaru, Tamori Akihiro, Murakami Yoshiki, Kawada Norifumi

    HEPATOLOGY RESEARCH   44 ( 4 )   371 - 376   2014.04( ISSN:1386-6346

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/hepr.12289

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  • Cytoglobin is expressed in hepatic stellate cells, but not in myofibroblasts, in normal and fibrotic human liver. Reviewed

    Motoyama H, Komiya T, Thuy le TT, Tamori A, Enomoto M, Morikawa H, Iwai S, Uchida-Kobayashi S, Fujii H, Hagihara A, Kawamura E, Murakami Y, Yoshizato K, Kawada N

    Laboratory investigation; a journal of technical methods and pathology   94 ( 2 )   192 - 207   2014.02( ISSN:0023-6837

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    DOI: 10.1038/labinvest.2013.135

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  • Relationship between inosine triphosphate genotype and outcome of extended therapy in hepatitis C virus patients with a late viral response to pegylated-interferon and ribavirin Reviewed

    Hai Hoang, Tamori Akihiro, Enomoto Masaru, Morikawa Hiroyasu, Uchida-Kobayashi Sawako, Fujii Hideki, Hagihara Atsushi, Kawamura Etsushi, Le Thi Thanh Thuy, Tanaka Yasuhito, Kawada Norifumi

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   29 ( 1 )   201 - 207   2014.01( ISSN:0815-9319

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    DOI: 10.1111/jgh.12376

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  • Effect of Caffeine-Containing Beverage Consumption on Serum Alanine Aminotransferase Levels in Patients with Chronic Hepatitis C Virus Infection: A Hospital-Based Cohort Study Reviewed

    Sasaki Yachiyo, Ohfuji Satoko, Fukushima Wakaba, Tamori Akihiro, Enomoto Masaru, Habu Daiki, Iwai Shuji, Uchida-Kobayashi Sawako, Fujii Hideki, Shiomi Susumu, Kawada Norifumi, Hirota Yoshio

    PLOS ONE   8 ( 12 )   e83382   2013.12( ISSN:1932-6203

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    DOI: 10.1371/journal.pone.0083382

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  • Physical inactivity and insufficient dietary intake are associated with the frequency of sarcopenia in patients with compensated viral liver cirrhosis Reviewed

    Hayashi Fumikazu, Matsumoto Yoshinari, Momoki Chika, Yuikawa Miho, Okada Genya, Hamakawa Erika, Kawamura Etsushi, Hagihara Atsushi, Toyama Madoka, Fujii Hideki, Kobayashi Sawako, Iwai Shuji, Morikawa Hiroyasu, Enomoto Masaru, Tamori Akihiro, Kawada Norifumi, Habu Daiki

    HEPATOLOGY RESEARCH   43 ( 12 )   1264 - 1275   2013.12( ISSN:1386-6346

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    DOI: 10.1111/hepr.12085

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  • 代償性ウイルス性肝硬変患者における身体低活動性と不十分な食事摂取量は筋肉減少症としばしば関連している(Physical inactivity and insufficient dietary intake are associated with the frequency of sarcopenia in patients with compensated viral liver cirrhosis) Reviewed

    Hayashi Fumikazu, Matsumoto Yoshinari, Momoki Chika, Yuikawa Miho, Okada Genya, Hamakawa Erika, Kawamura Etsushi, Hagihara Atsushi, Toyama Madoka, Fujii Hideki, Kobayashi Sawako, Iwai Shuji, Morikawa Hiroyasu, Enomoto Masaru, Tamori Akihiro, Kawada Norifumi, Habu Daiki

    John Wiley & Sons Australia, Ltd Hepatology Research   43 ( 12 )   1264 - 1275   2013.12( ISSN:1386-6346

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    肝硬変患者における栄養因子と筋肉減少症に関連があるかどうか検討した。41歳以上の肝硬変患者50名を被験者とし、食事習慣について面接を受け、日々の身体活動を歩数計により測定した。生体電気インピーダンス法を用いて四肢骨格筋量(ASM)を測定し、骨格筋体積指数(SMI)を算出した。握力計を用いて握力を測定した。筋肉減少症はSMIと握力から判定した。肝硬変患者を正常群と筋肉減少症群に分類し、2群の比較を行った。単変量および多変量ロジスティック回帰モデル化法を用いて肝硬変患者における筋肉減少症の罹患率を決定した。その結果、身長、理想体重(IBW)に対するエネルギー摂取量、そして歩数が筋肉減少症の独立の関連因子であった。さらに、筋肉減少症群では有意に多い数の患者がIBWに対するエネルギー摂取量と歩数の両方の指数で低い値を示した。以上の結果から、1日に5000歩以上の歩行と30kcal/IBWの総エネルギー摂取量を維持することで代償性肝硬変患者の生活様式の指針に関する基準が充足される可能性が示された。

  • 【日常臨床のジレンマ-NASHかASHか】NAFLDとアルコール性肝障害の鑑別におけるアルコール性肝障害/NAFLD指数(ANI)の有用性 Reviewed

    藤井 英樹, 榎本 大, 河田 則文

    (有)科学評論社 消化器内科   57 ( 6 )   733 - 736   2013.12( ISSN:1884-2895

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    通院中の脂肪肝患者213例(男性103例、女性110例、年齢55.7±14.1歳)を対象として、アルコール性肝障害(ALD)/非アルコール性肝障害(NAFLD)指数であるANIの有用性について検討した。その結果、ANIは1日飲酒量と正の相関が示され、アルコール性肝障害(ALD)患者では非アルコール性肝障害(NAFLD)患者と比べ、有意にANIが高値を示した。ANIのカットオフ値を-0.795とした場合、感度は68%、特異度は80%、陽性的中率は44%、陰性的中率は8%であった。多変量解析では、ANI以外にγ-GTPが峻別する独立した臨床検査値として抽出された。

  • Real-time PCR assays for hepatitis C virus RNA (genotype 1) is useful for evaluating virological response to the treatment with peginterferon-alpha2b and ribavirin. Reviewed

    Nakaya M, Enomoto M, Fujii H, Kobayashi S, Iwai S, Morikawa H, Tamori A, Sakaguchi H, Kawada N

    Osaka city medical journal   59 ( 2 )   79 - 89   2013.12( ISSN:0030-6096

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  • 【日常臨床のジレンマ-NASHかASHか】NAFLDとアルコール性肝障害の鑑別におけるアルコール性肝障害/NAFLD指数(ANI)の有用性

    藤井 英樹, 榎本 大, 河田 則文

    消化器内科   57 ( 6 )   733 - 736   2013.12( ISSN:1884-2895

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    通院中の脂肪肝患者213例(男性103例、女性110例、年齢55.7±14.1歳)を対象として、アルコール性肝障害(ALD)/非アルコール性肝障害(NAFLD)指数であるANIの有用性について検討した。その結果、ANIは1日飲酒量と正の相関が示され、アルコール性肝障害(ALD)患者では非アルコール性肝障害(NAFLD)患者と比べ、有意にANIが高値を示した。ANIのカットオフ値を-0.795とした場合、感度は68%、特異度は80%、陽性的中率は44%、陰性的中率は8%であった。多変量解析では、ANI以外にγ-GTPが峻別する独立した臨床検査値として抽出された。

  • Real-time PCR assays for hepatitis C virus RNA (genotype 1) is useful for evaluating virological response to the treatment with peginterferon-alpha2b and ribavirin.

    Nakaya M, Enomoto M, Fujii H, Kobayashi S, Iwai S, Morikawa H, Tamori A, Sakaguchi H, Kawada N

    Osaka city medical journal   59 ( 2 )   79 - 89   2013.12( ISSN:0030-6096

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  • 【B型肝炎ウイルスの再活性化の現状と対策】長期観察によるHBV再活性化頻度と治療介入例の予後 Reviewed

    田守 昭博, 榎本 大, 多田 昌弘, 小池 達也, 河田 則文

    (有)科学評論社 消化器内科   57 ( 5 )   586 - 590   2013.11( ISSN:1884-2895

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    B型肝炎ウイルス(HBV)再活性化による重篤な肝障害を阻止するためにはHBV DNA測定が推奨されているが、長期間に及ぶ測定を継続することは医療経済的に問題がある。そこで関節リウマチ(RA)症例とHBs抗原陽性例におけるHBV再活性化の実態を解析、更にエンテカビル(ETV)治療介入による肝炎阻止効果について検討した。研究1では2012年6月以前に生物学的製剤を導入したRA患者71例について2〜3ヵ月ごとにHBV DNAを測定し、再活性化の観察期間別頻度を調査した。研究2ではETV投与を実施したHBs抗原陽性13例(血液疾患6例、RA5例、腎移植2例)について長期効果を調べた。その結果、研究1では4年以上観察例20例、2〜4年観察23例、2年未満観察例28例であった。HBV再活性化は2年未満観察例に1例に認められたが、4年以上の長期観察例ではHBV再活性化は認めず、長期観察例に共通する臨床背景(HBs抗体価や使用薬剤など)は特定できなかった。一方、研究2ではHBs抗原陽性例の治療前HBV DNAは定量未満2例、2.3〜8.5logで、HBs抗原陽性13例中11例に対しETV0.5mg/日が投与された。尚、治療期間12〜60ヵ月において10例でHPV DNAは検出感度未満に低下した。

  • 【B型肝炎ウイルスの再活性化の現状と対策】長期観察によるHBV再活性化頻度と治療介入例の予後

    田守 昭博, 榎本 大, 多田 昌弘, 小池 達也, 河田 則文

    消化器内科   57 ( 5 )   586 - 590   2013.11( ISSN:1884-2895

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    B型肝炎ウイルス(HBV)再活性化による重篤な肝障害を阻止するためにはHBV DNA測定が推奨されているが、長期間に及ぶ測定を継続することは医療経済的に問題がある。そこで関節リウマチ(RA)症例とHBs抗原陽性例におけるHBV再活性化の実態を解析、更にエンテカビル(ETV)治療介入による肝炎阻止効果について検討した。研究1では2012年6月以前に生物学的製剤を導入したRA患者71例について2〜3ヵ月ごとにHBV DNAを測定し、再活性化の観察期間別頻度を調査した。研究2ではETV投与を実施したHBs抗原陽性13例(血液疾患6例、RA5例、腎移植2例)について長期効果を調べた。その結果、研究1では4年以上観察例20例、2〜4年観察23例、2年未満観察例28例であった。HBV再活性化は2年未満観察例に1例に認められたが、4年以上の長期観察例ではHBV再活性化は認めず、長期観察例に共通する臨床背景(HBs抗体価や使用薬剤など)は特定できなかった。一方、研究2ではHBs抗原陽性例の治療前HBV DNAは定量未満2例、2.3〜8.5logで、HBs抗原陽性13例中11例に対しETV0.5mg/日が投与された。尚、治療期間12〜60ヵ月において10例でHPV DNAは検出感度未満に低下した。

  • Combination therapy of natural human interferon-beta and ribavirin for chronic hepatitis C patients with injection drug use Reviewed

    Morikawa Hiroyasu, Kozuka Ritsuzo, Fujii Hideki, Iwai Shuji, Enomoto Masaru, Tamori Akihiro, Saito Shinobu, Kawada Norifumi

    HEPATOLOGY RESEARCH   43 ( 10 )   1013 - 1019   2013.10( ISSN:1386-6346

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    DOI: 10.1111/hepr.12066

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  • Combination therapy with a nucleos(t)ide analogue and interferon for chronic hepatitis B: simultaneous or sequential Reviewed

    Enomoto Masaru, Tamori Akihiro, Nishiguchi Shuhei, Kawada Norifumi

    JOURNAL OF GASTROENTEROLOGY   48 ( 9 )   999 - 1005   2013.09( ISSN:0944-1174

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    DOI: 10.1007/s00535-012-0742-5

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  • 通院中のNAFLD/NASH患者における食事・生活習慣に関する課題 Reviewed

    結川 美帆, 林 史和, 松本 佳也, 百木 和, 藤井 英樹, 遠山 まどか, 黒岡 浩子, 川村 悦史, 萩原 淳司, 小林 佐和子, 岩井 秀司, 森川 浩安, 榎本 大, 田守 昭博, 河田 則文, 塚田 定信, 羽生 大記

    (一社)日本病態栄養学会 日本病態栄養学会誌   16 ( 3 )   283 - 292   2013.09( ISSN:1345-8167

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    通院中のNAFLD 42名、NASH 58名、対照群として健常者57名において、生活習慣病の保健指導支援ソフトウェア"ヘルッチェ"(スズケン)や、生活習慣記録機ライフコーダ(スズケン)などを用いて、日常の生活習慣を分析した。結果、NAFLD/NASHでは健常者に比べ、体組成的に脂肪量が多く握力が低下している傾向が見られた。この傾向はNASH群においてより顕著であった。食習慣については、健常群と比して総摂取カロリーの過剰や、PFC比の偏りは見られず、食習慣改善に対するステージモデルにおいても、実行期・維持期の割合が有意に高く、意識して改善している傾向が見られた。しかし男性では健常者に比して魚介類の摂取量が少ないことなどから、摂取食品、食材にまで気を配った食事指導が望まれた。運動習慣について、身体活動量や歩数が低値を示し、生活活動強度が低い傾向が見られた。男女ともに、NAFLD/NASH群は自らの病識も明確で、食習慣は改善意識が高く改善傾向が見られたが、生活活動強度/運動習慣においては改善の余地があった。NAFLD/NASH患者には、食事指導のみならず、生活活動強度の向上、無理のないエクササイズ実施、継続など、包括的な生活改善支援が望まれる。(著者抄録)

  • 通院中のNAFLD/NASH患者における食事・生活習慣に関する課題

    結川 美帆, 林 史和, 松本 佳也, 百木 和, 藤井 英樹, 遠山 まどか, 黒岡 浩子, 川村 悦史, 萩原 淳司, 小林 佐和子, 岩井 秀司, 森川 浩安, 榎本 大, 田守 昭博, 河田 則文, 塚田 定信, 羽生 大記

    日本病態栄養学会誌   16 ( 3 )   283 - 292   2013.09( ISSN:1345-8167

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    通院中のNAFLD 42名、NASH 58名、対照群として健常者57名において、生活習慣病の保健指導支援ソフトウェア"ヘルッチェ"(スズケン)や、生活習慣記録機ライフコーダ(スズケン)などを用いて、日常の生活習慣を分析した。結果、NAFLD/NASHでは健常者に比べ、体組成的に脂肪量が多く握力が低下している傾向が見られた。この傾向はNASH群においてより顕著であった。食習慣については、健常群と比して総摂取カロリーの過剰や、PFC比の偏りは見られず、食習慣改善に対するステージモデルにおいても、実行期・維持期の割合が有意に高く、意識して改善している傾向が見られた。しかし男性では健常者に比して魚介類の摂取量が少ないことなどから、摂取食品、食材にまで気を配った食事指導が望まれた。運動習慣について、身体活動量や歩数が低値を示し、生活活動強度が低い傾向が見られた。男女ともに、NAFLD/NASH群は自らの病識も明確で、食習慣は改善意識が高く改善傾向が見られたが、生活活動強度/運動習慣においては改善の余地があった。NAFLD/NASH患者には、食事指導のみならず、生活活動強度の向上、無理のないエクササイズ実施、継続など、包括的な生活改善支援が望まれる。(著者抄録)

  • A pregnant woman with acute hepatitis B in whom vertical transmission was prevented by tenofovir disoproxil fumarate. Reviewed

    Tooyama M, Tamori A, Nakano A, Hai H, Thuy le TT, Enomoto M, Kawada N

    Clinical journal of gastroenterology   6 ( 2 )   173 - 6   2013.04( ISSN:1865-7257

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    DOI: 10.1007/s12328-013-0370-5

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  • Treatment guidelines for HCV genotype 1: mono for low, triple for high, and dual for 'middle'? Reviewed

    Enomoto Masaru, Tamori Akihiro, Kobayashi Sawako, Iwai Shuji, Morikawa Hiroyasu, Kawada Norifumi

    JOURNAL OF GASTROENTEROLOGY   48 ( 4 )   555 - 556   2013.04( ISSN:0944-1174

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    DOI: 10.1007/s00535-013-0759-4

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  • Entecavir and interferon-α sequential therapy in Japanese patients with hepatitis B e antigen-positive chronic hepatitis B Reviewed

    ENOMOTO Masaru, NISHIGUCHI Shuhei, TAMORI Akihiro, KOBAYASHI Sawako, SAKAGUCHI Hiroki, SHIOMI Susumu, KIM Soo Ryang, ENOMOTO Hirayuki, SAITO Masaki, IMANISHI Hiroyasu, KAWADA Norifumi

    Journal of gastroenterology   48 ( 3 )   397 - 404   2013.03( ISSN:09441174

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  • 経カテーテル的肝動脈塞栓術後に腫瘍崩壊症候群をきたした肝細胞癌の1例 Reviewed

    西田 裕, 藤井 英樹, 萩原 淳司, 川村 悦史, 岩井 秀司, 榎本 大, 田守 昭博, 荒川 哲男, 河田 則文

    (一財)日本消化器病学会 日本消化器病学会雑誌   110 ( 3 )   441 - 448   2013.03( ISSN:0446-6586

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    症例は70歳代、男性。肝細胞癌に対する経カテーテル的肝動脈塞栓術施行目的で入院した。術後に腫瘍崩壊症候群を発症したが、血液透析にて軽快した。また、一時的に肝機能障害および肝予備能低下を認めたものの保存的治療にて軽快した。巨大な肝細胞癌に対する肝動脈塞栓術後には、常に腫瘍崩壊症候群や肝予備能低下がおこる可能性に留意すべきと思われたため、若干の文献的考察を加え報告する。(著者抄録)

  • 経カテーテル的肝動脈塞栓術後に腫瘍崩壊症候群をきたした肝細胞癌の1例

    西田 裕, 藤井 英樹, 萩原 淳司, 川村 悦史, 岩井 秀司, 榎本 大, 田守 昭博, 荒川 哲男, 河田 則文

    日本消化器病学会雑誌   110 ( 3 )   441 - 448   2013.03( ISSN:0446-6586

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    症例は70歳代、男性。肝細胞癌に対する経カテーテル的肝動脈塞栓術施行目的で入院した。術後に腫瘍崩壊症候群を発症したが、血液透析にて軽快した。また、一時的に肝機能障害および肝予備能低下を認めたものの保存的治療にて軽快した。巨大な肝細胞癌に対する肝動脈塞栓術後には、常に腫瘍崩壊症候群や肝予備能低下がおこる可能性に留意すべきと思われたため、若干の文献的考察を加え報告する。(著者抄録)

  • A complete response induced by 21-day sorafenib therapy in a patient with advanced hepatocellular carcinoma. Reviewed

    Hagihara A, Teranishi Y, Kawamura E, Fujii H, Iwai S, Morikawa H, Enomoto M, Tamori A, Kawada N

    Internal medicine (Tokyo, Japan)   52 ( 14 )   1589 - 92   2013( ISSN:0918-2918

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    DOI: 10.2169/internalmedicine.52.9340

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  • Changes in sequences of core region, interferon sensitivity-determining region and interferon and ribavirin resistance-determining region of hepatitis C virus genotype 1 during interferon-alpha and ribavirin therapy, and efficacy of retreatment Reviewed

    Kozuka Ritsuzo, Enomoto Masaru, Hai Hoang, Ogawa Tomohiro, Nakaya Mika, Hagihara Atsushi, Fujii Hideki, Kobayashi Sawako, Iwai Shuji, Morikawa Hiroyasu, Tamori Akihiro, Kawada Norifumi

    HEPATOLOGY RESEARCH   42 ( 12 )   1157 - 1167   2012.12( ISSN:1386-6346

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    DOI: 10.1111/j.1872-034X.2012.01046.x

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  • MicroRNA-221/222 upregulation indicates the activation of stellate cells and the progression of liver fibrosis Reviewed

    Ogawa Tomohiro, Enomoto Masaru, Fujii Hideki, Sekiya Yumiko, Yoshizato Katsutoshi, Ikeda Kazuo, Kawada Norifumi

    GUT   61 ( 11 )   1600 - 1609   2012.11( ISSN:0017-5749

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    DOI: 10.1136/gutjnl-2011-300717

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  • Nutritional status in relation to lifestyle in patients with compensated viral cirrhosis Reviewed

    Hayashi Fumikazu, Momoki Chika, Yuikawa Miho, Simotani Yuko, Kawamura Etsushi, Hagihara Atsushi, Fujii Hideki, Kobayashi Sawako, Iwai Shuji, Morikawa Hiroyasu, Enomoto Masaru, Tamori Akihiro, Kawada Norifumi, Ohfuji Satoko, Fukusima Wakaba, Habu Daiki

    WORLD JOURNAL OF GASTROENTEROLOGY   18 ( 40 )   5759 - 5770   2012.10( ISSN:1007-9327

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    DOI: 10.3748/wjg.v18.i40.5759

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  • 肝硬変におけるサルコペニアの頻度と各種栄養評価法との関連性 Reviewed

    林 史和, 羽生 大記, 結川 美帆, 岡田 玄也, 濱川 恵梨香, 松本 佳也, 百木 和, 川村 悦史, 萩原 淳司, 遠山 まどか, 藤井 英樹, 小林 佐和子, 岩井 秀司, 森川 浩安, 榎本 大, 田守 昭博, 河田 則文, 塚田 定信

    日本病態栄養学会誌   15 ( 3 )   259 - 270   2012.09( ISSN:13458167

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  • 肝硬変におけるサルコペニアの頻度と各種栄養評価法との関連性

    林 史和, 羽生 大記, 結川 美帆, 岡田 玄也, 濱川 恵梨香, 松本 佳也, 百木 和, 川村 悦史, 萩原 淳司, 遠山 まどか, 藤井 英樹, 小林 佐和子, 岩井 秀司, 森川 浩安, 榎本 大, 田守 昭博, 河田 則文, 塚田 定信

    日本病態栄養学会誌   15 ( 3 )   259 - 270   2012.09( ISSN:13458167

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  • Anti-hepatitis B virus therapy: To stop, or not to stop: Has the question been solved? Reviewed

    Kozuka Ritsuzo, Enomoto Masaru, Morikawa Hiroyasu, Tamori Akihiro, Kawada Norifumi

    HEPATOLOGY RESEARCH   42 ( 9 )   946 - 947   2012.09( ISSN:1386-6346

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    DOI: 10.1111/j.1872-034X.2012.01001.x

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  • Induction of microRNA-214-5p in human and rodent liver fibrosis. Reviewed

    Iizuka M, Ogawa T, Enomoto M, Motoyama H, Yoshizato K, Ikeda K, Kawada N

    Fibrogenesis & tissue repair   5 ( 1 )   12   2012.08

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    DOI: 10.1186/1755-1536-5-12

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  • Effect of Mosapride Citrate on Gastric Emptying in Interferon-Induced Gastroparesis Reviewed

    Kawamura Etsushi, Enomoto Masaru, Kotani Kohei, Hagihara Atsushi, Fujii Hideki, Kobayashi Sawako, Iwai Shuji, Morikawa Hiroyasu, Kawabe Joji, Tominaga Kazunari, Tamori Akihiro, Shiomi Susumu, Kawada Norifumi

    DIGESTIVE DISEASES AND SCIENCES   57 ( 6 )   1510 - 1516   2012.06( ISSN:0163-2116

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    DOI: 10.1007/s10620-012-2085-8

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  • Response-guided therapy for patients with chronic hepatitis who have high viral loads of hepatitis C virus genotype 2 Reviewed

    Yamaguchi Yasunori, Tamori Akihiro, Tanaka Yasuhito, Iwai Shuji, Kobayashi Sawako, Fujii Hideki, Morikawa Hiroyasu, Hagihara Atsushi, Enomoto Masaru, Kawada Norifumi

    HEPATOLOGY RESEARCH   42 ( 6 )   549 - 557   2012.06( ISSN:1386-6346

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    DOI: 10.1111/j.1872-034X.2011.00956.x

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  • 肝細胞癌に対するミリプラチン動注療法後に発症した薬剤性肺障害の1例 Reviewed

    松浦 知香, 小林 佐和子, 大谷 香織, 吉田 香奈子, 寺西 優雅, 遠山 まどか, 萩原 淳司, 川村 悦史, 藤井 英樹, 岩井 秀司, 榎本 大, 田守 昭博, 中井 俊之, 鴨井 博, 平田 一人, 河田 則文

    (一社)日本肝臓学会 肝臓   53 ( 5 )   284 - 290   2012.05( ISSN:0451-4203

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    症例は69歳、男性。C型肝硬変・肝細胞癌(HCC)に対する治療を繰り返していたが、増悪したため、ミリプラチン動注療法目的で入院となった。第0病日、HCCに対してミリプラチン動注療法(計102mg)を施行した。第8病日頃より、咳嗽・喀痰が出現し、第17病日の胸部CTでは両側肺野のびまん性擦りガラス状陰影を認めた。PaO2 53Torrと著明な低酸素血症を認め、急性呼吸不全にて人工呼吸器管理とし、ステロイドパルス療法(メチルプレドニゾロン1g/日3日間)を開始した。その後徐々に呼吸状態は改善し、第24病日、人工呼吸器より離脱した。第53病日の胸部CTでは肺炎像は著明に改善していた。血液検査・喀痰培養・気管支肺胞洗浄などの結果から感染による肺炎は否定的であり、ミリプラチンによる薬剤性肺障害の可能性が高いと考えられた。(著者抄録)

  • 肝細胞癌に対するミリプラチン動注療法後に発症した薬剤性肺障害の1例

    松浦 知香, 小林 佐和子, 大谷 香織, 吉田 香奈子, 寺西 優雅, 遠山 まどか, 萩原 淳司, 川村 悦史, 藤井 英樹, 岩井 秀司, 榎本 大, 田守 昭博, 中井 俊之, 鴨井 博, 平田 一人, 河田 則文

    肝臓   53 ( 5 )   284 - 290   2012.05( ISSN:0451-4203

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    症例は69歳、男性。C型肝硬変・肝細胞癌(HCC)に対する治療を繰り返していたが、増悪したため、ミリプラチン動注療法目的で入院となった。第0病日、HCCに対してミリプラチン動注療法(計102mg)を施行した。第8病日頃より、咳嗽・喀痰が出現し、第17病日の胸部CTでは両側肺野のびまん性擦りガラス状陰影を認めた。PaO2 53Torrと著明な低酸素血症を認め、急性呼吸不全にて人工呼吸器管理とし、ステロイドパルス療法(メチルプレドニゾロン1g/日3日間)を開始した。その後徐々に呼吸状態は改善し、第24病日、人工呼吸器より離脱した。第53病日の胸部CTでは肺炎像は著明に改善していた。血液検査・喀痰培養・気管支肺胞洗浄などの結果から感染による肺炎は否定的であり、ミリプラチンによる薬剤性肺障害の可能性が高いと考えられた。(著者抄録)

  • 急性肝不全を呈するマクロファージ活性化症候群を合併した成人発症Still病の1例 Reviewed

    藤井 英樹, 武田 翔伍, 浅井 哲, 林 良樹, 今西 久幹, 榎本 大, 石井 正光, 日野 雅之, 根来 伸夫, 荒川 哲男, 河田 則文

    (一社)日本肝臓学会 肝臓   53 ( 3 )   155 - 163   2012.03( ISSN:0451-4203

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    症例は26歳、女性。発熱および肝機能障害にて入院。抗生剤治療不応の弛張熱と皮疹を特徴とし、肝生検などにより白血病や悪性リンパ腫などの疾患を除外して成人発症Still病と診断した。急性肝不全を呈し、ステロイドパルス療法によりいずれの臨床症状も軽快したが、ステロイドの減量によりすぐに再燃した。更に血球減少を呈するマクロファージ活性化症候群(macrophage activation syndrome、MAS)に移行した。シクロスポリンおよび静注用リポ化ステロイドの投与を開始したところMAS症状は改善し、第41病日に退院した。成人発症Still病に合併したMASにはシクロスポリンおよびリポ化ステロイドの治療が有用であった。(著者抄録)

  • 急性肝不全を呈するマクロファージ活性化症候群を合併した成人発症Still病の1例

    藤井 英樹, 武田 翔伍, 浅井 哲, 林 良樹, 今西 久幹, 榎本 大, 石井 正光, 日野 雅之, 根来 伸夫, 荒川 哲男, 河田 則文

    肝臓   53 ( 3 )   155 - 163   2012.03( ISSN:0451-4203

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    症例は26歳、女性。発熱および肝機能障害にて入院。抗生剤治療不応の弛張熱と皮疹を特徴とし、肝生検などにより白血病や悪性リンパ腫などの疾患を除外して成人発症Still病と診断した。急性肝不全を呈し、ステロイドパルス療法によりいずれの臨床症状も軽快したが、ステロイドの減量によりすぐに再燃した。更に血球減少を呈するマクロファージ活性化症候群(macrophage activation syndrome、MAS)に移行した。シクロスポリンおよび静注用リポ化ステロイドの投与を開始したところMAS症状は改善し、第41病日に退院した。成人発症Still病に合併したMASにはシクロスポリンおよびリポ化ステロイドの治療が有用であった。(著者抄録)

  • Benefits of Artificially Induced Pleural Effusion and/or Ascites for Percutaneous Radiofrequency Ablation of Hepatocellular Carcinoma Located on the Liver Surface and in the Hepatic Dome Reviewed

    Iwai Shuji, Sakaguchi Hiroki, Fujii Hideki, Kobayashi Sawako, Morikawa Hiroyasu, Enomoto Masaru, Tamori Akihiro, Kawada Norifumi

    HEPATO-GASTROENTEROLOGY   59 ( 114 )   546 - 550   2012( ISSN:0172-6390

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    DOI: 10.5754/hge11988

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  • Favorable factors for re-treatment with pegylated interferon α2a plus ribavirin in patients with high viral loads of genotype 1 hepatitis C virus Reviewed

    TAMORI Akihiro, KIOKA Kiyohide, KURAI Osamu, SAKAGUCHI Hiroki, ENOMOTO Masaru, FUJII Hideki, KOBAYASHI Sawako, IWAI Shuji, MORIKAWA Hiroyasu, YAMAGUCHI Seiko, KAWASAKI Yasuko, OKA Hiroko, TANAKA Yasuhito, KAWADA Norifumi

    Hepatology research : the official journal of the Japan Society of Hepatology   41 ( 12 )   1169 - 1177   2011.12( ISSN:13866346

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  • Could Trastuzumab Suppress Hepatitis C Virus in a Patient With Chronic Hepatitis and Breast Cancer? Reviewed

    Tamori Akihiro, Kawajiri Hidemi, Takashima Tsutomu, Motoyama Hiroyuki, Morikawa Hiroyasu, Enomoto Masaru, Hirakawa Kosei, Kawada Norifumi

    AMERICAN JOURNAL OF GASTROENTEROLOGY   106 ( 10 )   1865 - 1866   2011.10( ISSN:0002-9270

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    DOI: 10.1038/ajg.2011.258

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  • Close correlation of liver stiffness with collagen deposition and presence of myofibroblasts in non-alcoholic fatty liver disease Reviewed

    Mori Mami, Fujii Hideki, Ogawa Tomohiro, Kobayashi Sawako, Iwai Shuji, Morikawa Hiroyasu, Enomoto Masaru, Tamori Akihiro, Sawada Ayumi, Takeda Setsuko, Kawada Norifumi

    HEPATOLOGY RESEARCH   41 ( 9 )   897 - 903   2011.09( ISSN:1386-6346

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    DOI: 10.1111/j.1872-034X.2011.00842.x

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  • High prevalence of hepatitis C virus infection in Airin district, Osaka, Japan: A hospital-based study of 1162 patients Reviewed

    Yamaguchi Yasunori, Enomoto Masaru, Fujii Hideki, Tamori Akihiro, Sakaguchi Hiroki, Tanigawa Tetsuya, Watanabe Kenji, Fujiwara Yasuhiro, Arakawa Tetsuo, Harihara Shigeyoshi, Monna Takeyuki, Kawada Norifumi

    HEPATOLOGY RESEARCH   41 ( 8 )   731 - 737   2011.08( ISSN:1386-6346

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    DOI: 10.1111/j.1872-034X.2011.00834.x

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  • 肝細胞癌に対する内科的局所熱凝固療法の長期予後について Reviewed

    坂口 浩樹, 小塚 立蔵, 元山 宏行, 山口 康徳, 中屋 美香, 麻植 愛, 林 健博, 黒岡 浩子, 藤井 英樹, 小林 佐和子, 岩井 秀司, 森川 浩安, 榎本 大, 田守 昭博, 河田 則文

    (NPO)Microwave Surgery研究会 Journal of Microwave Surgery   29   123 - 126   2011.08( ISSN:0917-7728

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    著者らの施設で初回治療を行った肝細胞癌116例を、それぞれ経皮的RFA群35例、腹腔鏡的RFA群5例、経皮的MCT群22例、腹腔鏡的MCT群54例に分け、治療成績を比較検討した。その結果、5年局所再発率は経皮的RFA群40%、腹腔鏡的RFA群50%、経皮的MCT群50%、腹腔鏡的MCT群18%で有意差は認められなかった。一方、5年生存率も経皮的RFA群で78%、腹腔鏡的RFA群75%、経皮的MCT群82%、腹腔鏡的MCT群70%で有意差はみられなかった。

  • 人工胸腹水法を用いたラジオ波焼灼療法 適応と成績 Reviewed

    岩井 秀司, 松田 香奈子, 寺西 優雅, 荻原 淳司, 遠山 まどか, 藤井 英樹, 小林 佐和子, 森川 浩安, 榎本 大, 田森 昭博, 坂口 浩樹, 河田 則文

    (NPO)Microwave Surgery研究会 Journal of Microwave Surgery   29   105 - 107   2011.08( ISSN:0917-7728

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    著者らの施設で人工胸腹水法を用いて経皮的ラジオ波焼灼法(RFA)を施行した肝細胞癌60例を対象に、その適応と治療成績について検討した。原則としてHCCが肝腹側にあるものは人工腹水法、肝背側にあるものは人工胸水法、肝辺縁に位置するものは人工胸腹水法を選択することとした。内訳は人工胸水症例が26例、人工腹水症例が24例、人工胸腹水症例が10例であった。腫瘍局在は人工胸水症例がS6/S7/S8:1/10/15、人工腹水症例がS2/S3/S5/S6/S7/S8:1/2/3/2/4/12、人工胸腹水症例がS7/S8:4/6に位置していた。合併症としては腹腔内出血が1例と門脈血栓症が1例が認められた。平均観察期間24.2ヵ月の結果、初回治療32症例の3年生存率は78%で、全体の局所再発率は1年:4%、3年:22%であった。尚、腫瘍径3cm以上と3cm未満で局所再発率に有意差はなかった。また、局所再発率と生存率は各治療群の間で有意差はなかった。

  • 肝細胞癌に対する内科的局所熱凝固療法の長期予後について

    坂口 浩樹, 小塚 立蔵, 元山 宏行, 山口 康徳, 中屋 美香, 麻植 愛, 林 健博, 黒岡 浩子, 藤井 英樹, 小林 佐和子, 岩井 秀司, 森川 浩安, 榎本 大, 田守 昭博, 河田 則文

    Journal of Microwave Surgery   29   123 - 126   2011.08( ISSN:0917-7728

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    著者らの施設で初回治療を行った肝細胞癌116例を、それぞれ経皮的RFA群35例、腹腔鏡的RFA群5例、経皮的MCT群22例、腹腔鏡的MCT群54例に分け、治療成績を比較検討した。その結果、5年局所再発率は経皮的RFA群40%、腹腔鏡的RFA群50%、経皮的MCT群50%、腹腔鏡的MCT群18%で有意差は認められなかった。一方、5年生存率も経皮的RFA群で78%、腹腔鏡的RFA群75%、経皮的MCT群82%、腹腔鏡的MCT群70%で有意差はみられなかった。

  • 人工胸腹水法を用いたラジオ波焼灼療法 適応と成績

    岩井 秀司, 松田 香奈子, 寺西 優雅, 荻原 淳司, 遠山 まどか, 藤井 英樹, 小林 佐和子, 森川 浩安, 榎本 大, 田森 昭博, 坂口 浩樹, 河田 則文

    Journal of Microwave Surgery   29   105 - 107   2011.08( ISSN:0917-7728

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    著者らの施設で人工胸腹水法を用いて経皮的ラジオ波焼灼法(RFA)を施行した肝細胞癌60例を対象に、その適応と治療成績について検討した。原則としてHCCが肝腹側にあるものは人工腹水法、肝背側にあるものは人工胸水法、肝辺縁に位置するものは人工胸腹水法を選択することとした。内訳は人工胸水症例が26例、人工腹水症例が24例、人工胸腹水症例が10例であった。腫瘍局在は人工胸水症例がS6/S7/S8:1/10/15、人工腹水症例がS2/S3/S5/S6/S7/S8:1/2/3/2/4/12、人工胸腹水症例がS7/S8:4/6に位置していた。合併症としては腹腔内出血が1例と門脈血栓症が1例が認められた。平均観察期間24.2ヵ月の結果、初回治療32症例の3年生存率は78%で、全体の局所再発率は1年:4%、3年:22%であった。尚、腫瘍径3cm以上と3cm未満で局所再発率に有意差はなかった。また、局所再発率と生存率は各治療群の間で有意差はなかった。

  • [Natural history of hepatitis B virus infection].

    Toyama M, Enomoto M, Tamori A, Kawada N

    Nihon rinsho. Japanese journal of clinical medicine   69 Suppl 4   335 - 8   2011.05( ISSN:0047-1852

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  • Prospective study of reactivation of hepatitis B virus in patients with rheumatoid arthritis who received immunosuppressive therapy: evaluation of both HBsAg-positive and HBsAg-negative cohorts Reviewed

    Tamori Akihiro, Koike Tatsuya, Goto Hitoshi, Wakitani Shigeyuki, Tada Masahiro, Morikawa Hiroyasu, Enomoto Masaru, Inaba Masaaki, Nakatani Tatsuya, Hino Masayuki, Kawada Norifumi

    JOURNAL OF GASTROENTEROLOGY   46 ( 4 )   556 - 564   2011.04( ISSN:0944-1174

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    DOI: 10.1007/s00535-010-0367-5

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  • Real-time tissue elastography as a tool for the noninvasive assessment of liver stiffness in patients with chronic hepatitis C Reviewed

    Morikawa Hiroyasu, Fukuda Katsuhiko, Kobayashi Sawako, Fujii Hideki, Iwai Shuji, Enomoto Masaru, Tamori Akihiro, Sakaguchi Hiroki, Kawada Norifumi

    JOURNAL OF GASTROENTEROLOGY   46 ( 3 )   350 - 358   2011.03( ISSN:0944-1174

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00535-010-0301-x

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  • Sequential therapy with a nucleos(t)ide analogue and interferon in patients with chronic hepatitis B : efficacy and limitations Reviewed

    ENOMOTO Masaru, TAMORI Akihiro, NISHIGUCHI Shuhei, KAWADA Norifumi

    The Japanese Society of Gastroenterology, Nippon Shokakibyo Gakkai Zasshi   108 ( 2 )   215 - 222   2011.02( ISSN:04466586

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    DOI: 10.11405/nisshoshi.108.215

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  • 術前診断に苦慮した肝限局性結節性過形成(FNH)の一例 Reviewed

    小林 佐和子, 藤井 英樹, 岩井 秀司, 森川 浩安, 榎本 大, 田守 昭博, 坂口 浩樹, 竹村 茂一, 久保 正二, 河田 則文

    (株)新興医学出版社 Modern Physician   31 ( 2 )   259 - 263   2011.02( ISSN:0913-7963

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    70歳代女。近医でのCTで肝S4/8に2cm大の腫瘤を指摘され紹介入院となった。肝機能異常はなく、HBsとHBc抗体は陽性で、AFP、PIVKA-II、CEAは基準値内、超音波では肝S4/8に2cm大のhypoechoic lesionを認めた。ソナゾイド造影超音波血管相で中心部が造影されて辺縁へ濃染が広がり、明らかなspoke wheel patternはとらえられず、後血管相では明らかな欠損はなく、周囲と同程度の染影を認めた。MRIでは肝S4/8にT1強調像で等〜ごく淡い低信号、T2強調像で淡い高信号を呈する腫瘍像を認め、SPIO-MRIでは周囲肝実質と同程度で不均一にSPIOを取り込み、被膜様構造や中心瘢痕などは認めなかった。Kupffer細胞が示唆されたが画像では確定診断には至らず、経皮的肝生検で細胞密度の上昇とN/C比の増大を認め、高分化型肝細胞癌(HCC)として肝S4部分切除を施行した。腫瘤は16×15mm大で割面は腫瘤内部に中心瘢痕を認め、病理所見で結節は小型の肝細胞の過形成増殖で構成され、中心部に線維性結合織を認め、胆管増生を伴い明らかな異型細胞を認めず限局性結節性過形成(FNH)と診断した。

  • 術前診断に苦慮した肝限局性結節性過形成(FNH)の一例

    小林 佐和子, 藤井 英樹, 岩井 秀司, 森川 浩安, 榎本 大, 田守 昭博, 坂口 浩樹, 竹村 茂一, 久保 正二, 河田 則文

    Modern Physician   31 ( 2 )   259 - 263   2011.02( ISSN:0913-7963

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    70歳代女。近医でのCTで肝S4/8に2cm大の腫瘤を指摘され紹介入院となった。肝機能異常はなく、HBsとHBc抗体は陽性で、AFP、PIVKA-II、CEAは基準値内、超音波では肝S4/8に2cm大のhypoechoic lesionを認めた。ソナゾイド造影超音波血管相で中心部が造影されて辺縁へ濃染が広がり、明らかなspoke wheel patternはとらえられず、後血管相では明らかな欠損はなく、周囲と同程度の染影を認めた。MRIでは肝S4/8にT1強調像で等〜ごく淡い低信号、T2強調像で淡い高信号を呈する腫瘍像を認め、SPIO-MRIでは周囲肝実質と同程度で不均一にSPIOを取り込み、被膜様構造や中心瘢痕などは認めなかった。Kupffer細胞が示唆されたが画像では確定診断には至らず、経皮的肝生検で細胞密度の上昇とN/C比の増大を認め、高分化型肝細胞癌(HCC)として肝S4部分切除を施行した。腫瘤は16×15mm大で割面は腫瘤内部に中心瘢痕を認め、病理所見で結節は小型の肝細胞の過形成増殖で構成され、中心部に線維性結合織を認め、胆管増生を伴い明らかな異型細胞を認めず限局性結節性過形成(FNH)と診断した。

  • Artificial pleural effusion and/or ascites for percutaneous radiofrequency ablation of hepatocellular carcinoma Reviewed

    Iwai Shuji, Tamori Akihiro, Sakaguchi Hiroki, Kawada Norifumi, Matsuda Kanako, Teranishi Yuga, Hagihara Atsushi, Toyama Madoka, Fujii Hideki, Kobayashi Sawako, Morikawa Hiroyasu, Enomoto Masaru

    Study Group of Microwave Surgery, Journal of Microwave Surgery   ( 29 )   105 - 107   2011( ISSN:0917-7728

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    Radiofrequency ablation (RFA) with artificial pleural effusion and/or artificial ascites has recently been recognized as a useful device for the treatment of tumors located on the liver surface and in the hepatic dome. Sixty patients (including 32 naive patients) with hepatocellular carcinoma (HCC) underwent RFA with artificial pleural effusion and/or ascites. We decided the precise indication for the use of artificial infusion according to the location of tumor. The total local recurrence rates at 1 and 2 years were 4% and 22%, respectively. The estimated survival rates of 32 naive patients at 1 and 3 years were 90% and 78%, respectively. The local recurrence rates of a tumor size of <3 cm and >=3 cm at 2 years were 22% and 17%, respectively.

    DOI: 10.3380/jmicrowavesurg.29.105

    CiNii Article

  • Sequential therapy with a nucleos (t) ide analogue and interferon in patients with chronic hepatitis B: efficacy and limitations Reviewed

    ENOMOTO Masaru, TAMORI Akihiro, NISHIGUCHI Shuhei, KAWADA Norifumi

    Nippon Shokakibyo Gakkai Zasshi   108 ( 2 )   215 - 222   2011( ISSN:04466586

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    B型慢性肝炎に対する核酸アナログ治療では中止による肝炎の再燃と長期投与による耐性が問題となる.一方,インターフェロン(IFN)の治療効果も限定的である.Serfatyらは,IFNの前にラミブジンを先行投与するいわゆるsequential治療の良好な成績を報告した.その後,多くの施設で追試が行われたが,特にgenotype Cが多数を占める本邦での成績は芳しくない.一方,若年例,急性増悪例,ラミブジン投与中のウイルスの低下が良好な症例では著効も期待できることが明らかになってきた.今後,エンテカビルやPEG-IFNの使用も含め,sequential治療の位置づけについて更なる検討が必要である.<br>

    DOI: 10.11405/nisshoshi.108.215

    CiNii Article

  • Usefulness of transient elastography for assessment of liver fibrosis in chronic hepatitis B : Regression of liver stiffness during entecavir therapy Reviewed

    ENOMOTO Masaru, MORI Mami, OGAWA Tomohiro, FUJII Hideki, KOBAYASHI Sawako, IWAI Shuji, MORIKAWA Hiroyasu, TAMORI Akihiro, SAKAGUCHI Hiroki, SAWADA Ayumi, TAKEDA Setsuko, HABU Daiki, SHIOMI Susumu, KAWADA Norifumi

    Hepatology research : the official journal of the Japan Society of Hepatology   40 ( 9 )   853 - 861   2010.09( ISSN:13866346

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    CiNii Article

  • Usefulness of transient elastography for assessment of liver fibrosis in chronic hepatitis B: Regression of liver stiffness during entecavir therapy Reviewed

    Enomoto Masaru, Mori Mami, Ogawa Tomohiro, Fujii Hideki, Kobayashi Sawako, Iwai Shuji, Morikawa Hiroyasu, Tamori Akihiro, Sakaguchi Hiroki, Sawada Ayumi, Takeda Setsuko, Habu Daiki, Shiomi Susumu, Kawada Norifumi

    HEPATOLOGY RESEARCH   40 ( 9 )   853 - 861   2010.09( ISSN:1386-6346

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    DOI: 10.1111/j.1872-034X.2010.00687.x

    PubMed

  • HBV関連クリオグロブリン血症における抗ホスファチジルセリン・プロトロンビン複合体抗体の意義 Reviewed

    榎本 大, 根来 伸夫, 藤井 英樹, 小林 佐和子, 岩井 秀司, 森川 浩安, 田守 昭博, 坂口 浩樹, 羽生 大記, 塩見 進, 河田 則文

    (一社)日本肝臓学会 肝臓   51 ( 8 )   454 - 456   2010.08( ISSN:0451-4203

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    57歳女。両下肢の腫脹と紫斑を主訴とした。血清クリオグロブリン陽性と皮膚生検にて白血球破砕性血管炎を認め、B型肝炎ウイルス(HBV)DNA陽性でありHBV関連クリオグロブリン血管炎と診断した。エンテカビル投与によりHBV DNAは6週目までに陰性化し、治療前390〜510U/mLと高力価を認めた抗ホスファチジルセリン・プロトロンビン複合体(anti-PS/PT)は24週目に69U/mLまで低下した。クリオグロブリンも陰性化し紫斑は徐々に消失した。一方、肝外病変を認めないB型慢性肝疾患20例(男16例、女4例、平均年齢50歳)のうち8例(40%)からanti-PS/PT陽性を検出したがいずれも低力価であり、anti-PS/PT陽性例と陰性例の間に臨床的差異は認めなかった。HBV関連クリオグロブリン血症の成立にanti-PS/PTが関与している可能性が考えられた。

  • 肝細胞癌に対する腹腔鏡的熱凝固療法におけるマイクロ波とラジオ波の違いについて Reviewed

    坂口 浩樹, 小塚 立蔵, 元山 宏行, 山口 康徳, 中屋 美香, 麻植 愛, 林 健博, 黒岡 浩子, 藤井 英樹, 小林 佐和子, 岩井 秀司, 森川 浩安, 榎本 大, 田守 昭博, 河田 則文

    (NPO)Microwave Surgery研究会 Journal of Microwave Surgery   28   43 - 46   2010.08( ISSN:0917-7728

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    肝細胞癌(HCC)に対して腹腔鏡的熱凝固療法を行い、マイクロ波凝固療法(MCT)例とラジオ波凝固療法(RFA)例との違いを検討した。対象は、MCT:28症例28結節、RFA:31症例38結節とした。平均腫瘍径は、MCT:19.2mm、RFA:26.4mmであった。腫瘍局在は、MCTは、S2:2結節、S3:15結節、S4:2結節、S5:4結節、S6:1結節、S8:4結節、RFAは、S3:11結節、S4:7結節、S5:11結節、S6:1結節、S7:3結節、S8:5結節であった。治療効果は、MCT、RFAに関わらず、全症例ともsafety marginを保ってHCCは凝固されていた。腹腔鏡的熱凝固療法においては、腫瘍径や腫瘍の局在によってMCTとRFAとを使い分けることにより、安全、かつ正確な治療を行うことが可能であることが示された。

  • ソナゾイド造影エコー導入による当科での肝細胞癌局所治療の変化 Reviewed

    小林 佐和子, 山口 康徳, 小塚 立蔵, 元山 宏行, 麻植 愛, 林 健博, 藤井 英樹, 黒岡 浩子, 岩井 秀司, 榎本 大, 森川 浩安, 田守 昭博, 坂口 浩樹, 河田 則文

    (NPO)Microwave Surgery研究会 Journal of Microwave Surgery   28   35 - 38   2010.08( ISSN:0917-7728

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    肝細胞癌(HCC)に対するソナゾイドを用いた造影超音波検査(US)について検討した。対象は2006年1月から2009年4月に治療を施行もしくは施行を検討した初発HCCの125症例179結節で、造影US導入前:48症例82結節、US導入後:77症例97結節に分けた。造影USによるHCCの正診率は90.2%で、造影CT・MRIの83.6%に劣らない結果が得られた。治療前に超音波で描出できなかったために局所治療不能であった病変は導入前:13.2%(11結節)、導入後:3.1%(3結節)で、導入後、有意に減少した。また、局所治療後、腫瘍残存が指摘されたのは導入前:9.9%(7/71結節)、導入後:6.6%(6/90結節)であった。HCCに対する造影USは診断、治療支援などに有用であり、造影USを積極的に行うことでHCCに対する局所治療の確実性が増し、治療効果向上が期待できると思われた。

  • 肝細胞癌に対する腹腔鏡的熱凝固療法におけるマイクロ波とラジオ波の違いについて

    坂口 浩樹, 小塚 立蔵, 元山 宏行, 山口 康徳, 中屋 美香, 麻植 愛, 林 健博, 黒岡 浩子, 藤井 英樹, 小林 佐和子, 岩井 秀司, 森川 浩安, 榎本 大, 田守 昭博, 河田 則文

    Journal of Microwave Surgery   28   43 - 46   2010.08( ISSN:0917-7728

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    肝細胞癌(HCC)に対して腹腔鏡的熱凝固療法を行い、マイクロ波凝固療法(MCT)例とラジオ波凝固療法(RFA)例との違いを検討した。対象は、MCT:28症例28結節、RFA:31症例38結節とした。平均腫瘍径は、MCT:19.2mm、RFA:26.4mmであった。腫瘍局在は、MCTは、S2:2結節、S3:15結節、S4:2結節、S5:4結節、S6:1結節、S8:4結節、RFAは、S3:11結節、S4:7結節、S5:11結節、S6:1結節、S7:3結節、S8:5結節であった。治療効果は、MCT、RFAに関わらず、全症例ともsafety marginを保ってHCCは凝固されていた。腹腔鏡的熱凝固療法においては、腫瘍径や腫瘍の局在によってMCTとRFAとを使い分けることにより、安全、かつ正確な治療を行うことが可能であることが示された。

  • ソナゾイド造影エコー導入による当科での肝細胞癌局所治療の変化

    小林 佐和子, 山口 康徳, 小塚 立蔵, 元山 宏行, 麻植 愛, 林 健博, 藤井 英樹, 黒岡 浩子, 岩井 秀司, 榎本 大, 森川 浩安, 田守 昭博, 坂口 浩樹, 河田 則文

    Journal of Microwave Surgery   28   35 - 38   2010.08( ISSN:0917-7728

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    肝細胞癌(HCC)に対するソナゾイドを用いた造影超音波検査(US)について検討した。対象は2006年1月から2009年4月に治療を施行もしくは施行を検討した初発HCCの125症例179結節で、造影US導入前:48症例82結節、US導入後:77症例97結節に分けた。造影USによるHCCの正診率は90.2%で、造影CT・MRIの83.6%に劣らない結果が得られた。治療前に超音波で描出できなかったために局所治療不能であった病変は導入前:13.2%(11結節)、導入後:3.1%(3結節)で、導入後、有意に減少した。また、局所治療後、腫瘍残存が指摘されたのは導入前:9.9%(7/71結節)、導入後:6.6%(6/90結節)であった。HCCに対する造影USは診断、治療支援などに有用であり、造影USを積極的に行うことでHCCに対する局所治療の確実性が増し、治療効果向上が期待できると思われた。

  • HBV関連クリオグロブリン血症における抗ホスファチジルセリン・プロトロンビン複合体抗体の意義

    榎本 大, 根来 伸夫, 藤井 英樹, 小林 佐和子, 岩井 秀司, 森川 浩安, 田守 昭博, 坂口 浩樹, 羽生 大記, 塩見 進, 河田 則文

    肝臓   51 ( 8 )   454 - 456   2010.08( ISSN:0451-4203

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    57歳女。両下肢の腫脹と紫斑を主訴とした。血清クリオグロブリン陽性と皮膚生検にて白血球破砕性血管炎を認め、B型肝炎ウイルス(HBV)DNA陽性でありHBV関連クリオグロブリン血管炎と診断した。エンテカビル投与によりHBV DNAは6週目までに陰性化し、治療前390〜510U/mLと高力価を認めた抗ホスファチジルセリン・プロトロンビン複合体(anti-PS/PT)は24週目に69U/mLまで低下した。クリオグロブリンも陰性化し紫斑は徐々に消失した。一方、肝外病変を認めないB型慢性肝疾患20例(男16例、女4例、平均年齢50歳)のうち8例(40%)からanti-PS/PT陽性を検出したがいずれも低力価であり、anti-PS/PT陽性例と陰性例の間に臨床的差異は認めなかった。HBV関連クリオグロブリン血症の成立にanti-PS/PTが関与している可能性が考えられた。

  • Add-on combination therapy with adefovir dipivoxil induces renal impairment in patients with lamivudine-refractory hepatitis B virus Reviewed

    A. Tamori, M. Enomoto, S. Kobayashi, S. Iwai, H. Morikawa, H. Sakaguchi, D. Habu, S. Shiomi, Y. Imanishi, N. Kawada

    JOURNAL OF VIRAL HEPATITIS   17 ( 2 )   123 - 9   2010.02( ISSN:1352-0504

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    Combination therapy with adefovir dipivoxil (ADV) and lamivudine (LAM) is recommended for patients infected with LAM-refractory hepatitis B virus (HBV). However, the effects of such therapy on renal function and serum phosphorus levels have not been fully evaluated. Combination therapy with ADV and LAM was given to 37 patients infected with LAM-refractory HBV, including 17 with hepatic cirrhosis. Serum HBV DNA levels decreased to below 2.6 log(10) copies/mL in 23 (62%) of 37 patients at 12 months, 25 (78%) of 32 patients at 24 months, and 16 (84%) of 19 patients at 36 months. Except for one cirrhotic patient, serum alanine aminotransferase levels were below 50 IU/L in all patients during combination therapy. Serum creatinine levels increased in 14 (38%) of 37 patients, and serum phosphate levels decreased to below 2.5 mg/mL in 6 (16%) of 37 patients during combination therapy. Patients who received combination therapy for 36 months or longer had a significantly incidence of elevated serum creatinine levels. Fanconi syndrome occurred in a 57-year-old woman with cirrhosis after ADV was added to LAM. Combination therapy with ADV and LAM can maintain biochemical remission in patients with LAM-refractory HBV. However, the dosing interval of ADV should be adjusted according to renal function and serum phosphate levels in patients receiving long-term treatment.

    DOI: 10.1111/j.1365-2893.2009.01160.x

    PubMed

  • Add-on combination therapy with adefovir dipivoxil induces renal impairment in patients with lamivudine-refractory hepatitis B virus Reviewed

    Tamori A., Enomoto M., Kobayashi S., Iwai S., Morikawa H., Sakaguchi H., Habu D., Shiomi S., Imanishi Y., Kawada N.

    JOURNAL OF VIRAL HEPATITIS   17 ( 2 )   123 - 129   2010.02( ISSN:1352-0504

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    DOI: 10.1111/j.1365-2893.2009.01160.x

  • Applicability of BARD score to Japanese patients with NAFLD Reviewed

    Fujii H., Enomoto M., Fukushima W., Tamori A., Sakaguchi H., Kawada N.

    GUT   58 ( 11 )   1566 - 1567   2009.11( ISSN:0017-5749

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    DOI: 10.1136/gut.2009.182758

  • Comparison of the effect of BCAA granules on between decompensated and compensated cirrhosis. Reviewed

    Habu D, Nishiguchi S, Nakatani S, Lee C, Enomoto M, Tamori A, Takeda T, Ohfuji S, Fukushima W, Tanaka T, Kawamura E, Shiomi S

    Hepato-gastroenterology   56 ( 96 )   1719 - 23   2009.11( ISSN:0172-6390

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    PubMed

  • Comparison of the effect of BCAA granules on between decompensated and compensated cirrhosis.

    Habu D, Nishiguchi S, Nakatani S, Lee C, Enomoto M, Tamori A, Takeda T, Ohfuji S, Fukushima W, Tanaka T, Kawamura E, Shiomi S

    Hepato-gastroenterology   56 ( 96 )   1719 - 23   2009.11( ISSN:0172-6390

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  • Emerging antiviral drugs for hepatitis C virus. Reviewed

    Enomoto M, Tamori A, Kawada N

    Reviews on recent clinical trials   4 ( 3 )   179 - 84   2009.09( ISSN:1574-8871

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    PubMed

  • Early-onset functional dyspeptia confirmed using scintigraphic gastric emptying in anti-hepatitis C viral therapy Reviewed

    Kawamura E., Shiomi S., Higashiyama S., Fujii H., Kobayashi S., Yasuda T., Morikawa H., Enomoto M., Kawabe J., Tamori A., Sakaguchi H., Kawada N.

    EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING   36   S440 - S440   2009.09( ISSN:1619-7070

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  • Early-onset functional dyspeptia confirmed using scintigraphic gastric emptying in anti-hepatitis C viral therapy Reviewed

    Kawamura E, Shiomi S, Higashiyama S, Fujii H, Kobayashi S, Yasuda T, Morikawa H, Enomoto M, Kawabe J, Tamori A, Sakaguchi H, Kawada N

    EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING   36   S440 - S440   2009.09( ISSN:1619-7070

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  • A Randomized Pilot Trial of Oral Branched-Chain Amino Acids in Early Cirrhosis: Validation Using Prognostic Markers for Pre-Liver Transplant Status Reviewed

    Kawamura Etsushi, Habu Daiki, Morikawa Hiroyasu, Enomoto Masaru, Kawabe Joji, Tamori Akihiro, Sakaguchi Hiroki, Saeki Shigeru, Kawada Norifumi, Shiomi Susumu

    LIVER TRANSPLANTATION   15 ( 7 )   790 - 797   2009.07( ISSN:1527-6465

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    DOI: 10.1002/lt.21758

    PubMed

  • Noninvasive laboratory tests proposed for predicting cirrhosis in patients with chronic hepatitis C are also useful in patients with non-alcoholic steatohepatitis

    FUJII Hideki, ENOMOTO Masaru, FUKUSHIMA Wakaba, OHFUJI Satoko, MORI Mami, KOBAYASHI Sawako, IWAI Shuji, MORIKAWA Hiroyasu, TAMORI Akihiro, SAKAGUCHI Hiroki, IKURA Yoshihiro, UEDA Makiko, KAWADA Norifumi

    44 ( 6 )   608 - 614   2009.06( ISSN:09441174

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  • Frequent Detection of Hepatitis B Virus DNA in Hepatocellular Carcinoma of Patients With Sustained Virologic Response for Hepatitis C Virus Reviewed

    Tamori Akihiro, Hayashi Takehiro, Shinzaki Mayumi, Kobayashi Sawako, Iwai Shuji, Enomoto Masaru, Morikawa Hiroyasu, Sakaguchi Hiroki, Shiomi Susumu, Takemura Shigekazu, Kubo Shoji, Kawada Norifumi

    JOURNAL OF MEDICAL VIROLOGY   81 ( 6 )   1009 - 1014   2009.06( ISSN:0146-6615

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    DOI: 10.1002/jmv.21488

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  • Two cases of hepatocellular adenomatosis treated with transcatheter arterial embolization Reviewed

    Kobayashi Sawako, Sakaguchi Hiroki, Takatsuka Masaki, Suekane Takehisa, Iwai Shuji, Morikawa Hiroyasu, Enomoto Masaru, Tamori Akihiro, Kawada Norifumi

    HEPATOLOGY INTERNATIONAL   3 ( 2 )   416 - 420   2009.06( ISSN:1936-0533

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    DOI: 10.1007/s12072-009-9126-1

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  • Noninvasive laboratory tests proposed for predicting cirrhosis in patients with chronic hepatitis C are also useful in patients with non-alcoholic steatohepatitis Reviewed

    Fujii Hideki, Enomoto Masaru, Fukushima Wakaba, Ohfuji Satoko, Mori Mami, Kobayashi Sawako, Iwai Shuji, Morikawa Hiroyasu, Tamori Akihiro, Sakaguchi Hiroki, Ikura Yoshihiro, Ueda Makiko, Kawada Norifumi

    JOURNAL OF GASTROENTEROLOGY   44 ( 6 )   608 - 614   2009.06( ISSN:0944-1174

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    DOI: 10.1007/s00535-009-0046-6

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  • A case of autoimmune hepatitis showing resistance to a steroid and immunosuppressants Reviewed

    KOZUKA Ritsuzo, IWAI Shuji, TOYAMA Madoka, FUJII Hideki, YASUDA Takahiro, KOBAYASHI Sawako, KUROOKA Hiroko, NAKAYAMA Yuji, ENOMOTO Masaru, MORIKAWA Hiroyasu, TAMORI Akihiro, SAKAGUCHI Hiroki, KAWADA Norifumi

    The Japan Society of Hepatology, Kanzo   50 ( 6 )   223 - 228   2009.05( ISSN:04514203

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    A 27-year-old woman consulted a doctor with nasal congestion. At that time, a high level of &gamma;-globulin and IgG was observed in her blood test. Afterwards, she was admitted to our hospital because of a high level of serum transaminases. We diagnosed her disease as autoimmune hepatitis following the results of several serum tests and the liver histopathology obtained by liver biopsy. She was initially treated with prednisolone (PSL) 30 mg/day. Because we found that the steroid treatment was insufficient, we further added azathioprine (AZA) 50 mg/day to the steroid. Use of AZA showed some effect. However, the hepatopathy did not improve and the medication was changed to cyclosporine (CYA) because agranulocytosis was observed as a side effect. The patient died following a sudden decline of consciousness and acute respiratory failure due to a pneumocystis carinii infection. We here report a case that showed resistance to treatment using a steroid, AZA, and CYA.<br>

    DOI: 10.2957/kanzo.50.223

    CiNii Article

  • Sildenafil-Induced Severe Cholestatic Hepatotoxicity Reviewed

    Enomoto Masaru, Sakaguchi Hiroki, Ominami Masaki, Iwai Shuji, Morikawa Hiroyasu, Tamori Akihiro, Kawada Norifumi

    AMERICAN JOURNAL OF GASTROENTEROLOGY   104 ( 1 )   254 - 255   2009.01( ISSN:0002-9270

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    DOI: 10.1038/ajg.2008.18

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  • Differences in molecular alterations of hepatocellular carcinoma between patients with a sustained virological response and those with hepatitis C virus infection Reviewed

    Hayashi Takehiro, Tamori Akihiro, Nishikawa Manabu, Morikawa Hiroyasu, Enomoto Masaru, Sakaguchi Hiroki, Habu Daiki, Kawada Norifumi, Kubo Shoji, Nishiguchi Shuhei, Shiomi Susumu

    LIVER INTERNATIONAL   29 ( 1 )   126 - 132   2009.01( ISSN:1478-3223

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    DOI: 10.1111/j.1478-3231.2008.01772.x

    PubMed

  • A case of autoimmune hepatitis showing resistance to a steroid and immunosuppressants

    Kozuka Ritsuzo, Iwai Shuji, Toyama Madoka, Fujii Hideki, Yasuda Takahiro, Kobayashi Sawako, Kurooka Hiroko, Nakayama Yuji, Enomoto Masaru, Morikawa Hiroyasu, Tamori Akihiro, Sakaguchi Hiroki, Kawada Norifumi

    Kanzo   50 ( 5 )   223 - 228   2009( ISSN:04514203

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    A 27-year-old woman consulted a doctor with nasal congestion. At that time, a high level of γ-globulin and IgG was observed in her blood test. Afterwards, she was admitted to our hospital because of a high level of serum transaminases. We diagnosed her disease as autoimmune hepatitis following the results of several serum tests and the liver histopathology obtained by liver biopsy. She was initially treated with prednisolone (PSL) 30 mg/day. Because we found that the steroid treatment was insufficient, we further added azathioprine (AZA) 50 mg/day to the steroid. Use of AZA showed some effect. However, the hepatopathy did not improve and the medication was changed to cyclosporine (CYA) because agranulocytosis was observed as a side effect. The patient died following a sudden decline of consciousness and acute respiratory failure due to a pneumocystis carinii infection. We here report a case that showed resistance to treatment using a steroid, AZA, and CYA.<br>

    DOI: 10.2957/kanzo.50.223

    CiNii Article

  • Entecavir to treat hepatitis B-associated cryoglobulinemic vasculitis. Reviewed

    Enomoto M, Nakanishi T, Ishii M, Tamori A, Kawada N

    Annals of internal medicine   149 ( 12 )   912 - 3   2008.12( ISSN:0003-4819

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    PubMed

  • A case of primary small cell carcinoma of the liver that was treated with chemotherapy Reviewed

    Morikawa Hiroyasu, Nakayama Yuji, Maeda Takako, Nadatani Yuji, Kobayashi Sawako, Iwai Shuji, Enomoto Masaru, Tamori Akihiro, Sakaguchi Hiroki, Oshitani Nobuhide, Kudoh Shinzoh, Kawada Norifumi

    HEPATOLOGY INTERNATIONAL   2 ( 4 )   500 - 504   2008.12( ISSN:1936-0533

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    DOI: 10.1007/s12072-008-9090-1

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  • Platelet-associated IgG for the diagnosis of immune thrombocytopaenic purpura during peginterferon alpha and ribavirin treatment for chronic hepatitis C Reviewed

    Enomoto Masaru, Yamane Takahisa, Hino Masayuki, Ohnishi Miho, Tamori Akihiro, Kawada Norifumi

    LIVER INTERNATIONAL   28 ( 9 )   1314 - 1315   2008.10( ISSN:1478-3223

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    DOI: 10.1111/j.1478-3231.2008.01747.x

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  • Optimal duration of additional therapy after biochemical and virological responses to lamivudine in patients with HBeAg-negative chronic hepatitis B: a randomized trial Reviewed

    Enomoto Masaru, Tamori Akihiro, Kohmoto Madoka Toyama, Hayashi Takehiro, Morikawa Hiroyasu, Jomura Hisato, Sakaguchi Hiroki, Habu Daiki, Kawada Norifumi, Shiomi Susumu, Nishiguchi Shuhei

    HEPATOLOGY RESEARCH   38 ( 9 )   954 - 959   2008.09( ISSN:1386-6346

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    DOI: 10.1111/j.1872-034X.2008.00378.x

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  • Drug-induced liver injury caused by a herbal medicine, bofu-tsu-sho-san Reviewed

    MOTOYAMA Hiroyuki, ENOMOTO Masaru, YASUDA Takahiro, FUJII Hideki, KOBAYASHI Sawako, IWAI Shuji, MORIKAWA Hiroyasu, TAKEDA Tadashi, TAMORI Akihiro, SAKAGUCHI Hiroki, KAWADA Norifumi

    The Japanese Society of Gastroenterology, Nippon Shokakibyo Gakkai Zasshi   105 ( 8 )   1234 - 1239   2008.08( ISSN:04466586

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    A 37-year-old woman was admitted to a hospital with jaundice. Within a couple of weeks, her liver function improved with only symptomatic therapy. About 30 to 60 days before admission, she had taken a herbal medicine, bofu-tsu-sho-san. A diagnosis of drug-induced liver injury was made according to the diagnostic scale proposed at the Digestive Disease Week-Japan 2004. A drug-lymphocyte stimulation test for each ingredient of bofu-tsu-sho-san; the results were positive for <i>Cnidii Rhizoma</i>, <i>Angelicae Radix</i> and <i>Menthae Herba</i>. The liver biopsy specimen revealed features of acute hepatitis. Physicians should be aware that bofu-tsu-sho-san can cause liver injury, as this drug is commonly used as an over-the-counter medicine.<br>

    DOI: 10.11405/nisshoshi.105.1234

    CiNii Article

  • Clinical role of FDG-PET for HCC: relationship of glucose metabolic indicator to Japan Integrated Staging (JIS) score. Reviewed

    Kawamura E, Habu D, Ohfuji S, Fukushima W, Enomoto M, Torii K, Kawabe J, Kondo K, Tamori A, Kawada N, Shiomi S

    Hepato-gastroenterology   55 ( 82-83 )   582 - 6   2008.03( ISSN:0172-6390

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    PubMed

  • Clinical role of FDG-PET for HCC: relationship of glucose metabolic indicator to Japan Integrated Staging (JIS) score.

    Kawamura E, Habu D, Ohfuji S, Fukushima W, Enomoto M, Torii K, Kawabe J, Kondo K, Tamori A, Kawada N, Shiomi S

    Hepato-gastroenterology   55 ( 82-83 )   582 - 6   2008.03( ISSN:0172-6390

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  • Laparoscopic thermal ablation therapy for hepatocellular carcinoma with forward-viewing laparoscopic ultrasonography (End-Fire array) Reviewed

    Sakaguchi Hiroki, Seki Shuichi, Fujii Hideki, Yasuda Takahiro, Kobayashi Sawako, Iwai Shuji, Morikawa Hiroyasu, Enomoto Masaru, Tamori Akihiro, Kawada Norifumi

    Study Group of Microwave Surgery, Journal of Microwave Surgery   ( 26 )   85 - 88   2008( ISSN:0917-7728

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    Laparoscopic thermal ablation for hepatocellular carcinoma (HCC) is thought to be more accurate technique than percutaneous ablation, because HCC can be treated under direct vision. However, it is difficult to puncture deep-seated whepatic tumors under standard linear-type laparoscopic ultrasonography. Forward-viewing laparoscopic ultrasonography (End-Fire array), which was recently been developed, enables us to puncture deep-seated HCC exactly. We have performed laparoscopic thermal ablation for 8 HCCs out of 7 patients by using this End-Fire array. Among them, three were treated by microwave coagulation and four were by radiofrequency ablation. Six of 7 patients were completely and easily treated with this array. One patient had multiple HCCs and two relatively large HCCs were ablated for mass reduction. Thus, this new array is useful to perform laparoscopic thermal ablation against deep-seated HCC.

    DOI: 10.3380/jmicrowavesurg.26.85

    CiNii Article

  • Alternative methods of radiofrequencty ablation for hepatocellular carcinoma located close to the hepatic dome Reviewed

    Iwai Shuji, Sakaguchi Hiroki, Yasuda Takahiro, Fujii Hideki, Morikawa Hiroyasu, Enomoto Masaru, Tamori Akihiro, Kawada Norifumi

    Study Group of Microwave Surgery, Journal of Microwave Surgery   ( 26 )   63 - 65   2008( ISSN:0917-7728

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    We have performed alternative methods of ablation, which are laparoscopic radiofrequency ablation (LRFA) and percutaneous radiofrequency ablation with artificial pleural effusion (PRFA with APE), for hepatocellular carcinoma (HCC) located close to the hepatic dome. HCC located in this area is considered to be difficult to achieve complete necrosis by radiofrequency ablation. We treated total 27 cases of HCCs located in this area. Nine and 18 cases were treated by LRFA and PRFA with APE, respectively. The tumor size and number of session in LRFA group were significantly high in PRFA with APE. As a result, 2-year survival rate in LRFA group (76%) and PRFA with APE group (80%) was not significantly different from standard PRFA (93%). Thus, LRFA and PRFA with APE were efficient approaches for HCC located in hepatic dome.

    DOI: 10.3380/jmicrowavesurg.26.63

    CiNii Article

  • Alternative methods of radiofrequencty ablation for hepatocellular carcinoma located close to the hepatic dome

    Iwai Shuji, Sakaguchi Hiroki, Yasuda Takahiro, Fujii Hideki, Morikawa Hiroyasu, Enomoto Masaru, Tamori Akihiro, Kawada Norifumi

    Journal of Microwave Surgery   26   63 - 65   2008( ISSN:09177728

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    We have performed alternative methods of ablation, which are laparoscopic radiofrequency ablation (LRFA) and percutaneous radiofrequency ablation with artificial pleural effusion (PRFA with APE), for hepatocellular carcinoma (HCC) located close to the hepatic dome. HCC located in this area is considered to be difficult to achieve complete necrosis by radiofrequency ablation. We treated total 27 cases of HCCs located in this area. Nine and 18 cases were treated by LRFA and PRFA with APE, respectively. The tumor size and number of session in LRFA group were significantly high in PRFA with APE. As a result, 2-year survival rate in LRFA group (76%) and PRFA with APE group (80%) was not significantly different from standard PRFA (93%). Thus, LRFA and PRFA with APE were efficient approaches for HCC located in hepatic dome.

    DOI: 10.3380/jmicrowavesurg.26.63

    CiNii Article

  • Laparoscopic thermal ablation therapy for hepatocellular carcinoma with forward-viewing laparoscopic ultrasonography (End-Fire array)

    Sakaguchi Hiroki, Fujii Hideki, Yasuda Takahiro, Kobayashi Sawako, Iwai Shuji, Morikawa Hiroyasu, Enomoto Masaru, Tamori Akihiro, Kawada Norifumi, Seki Shuichi

    Journal of Microwave Surgery   26   85 - 88   2008( ISSN:09177728

     More details

    Laparoscopic thermal ablation for hepatocellular carcinoma (HCC) is thought to be more accurate technique than percutaneous ablation, because HCC can be treated under direct vision. However, it is difficult to puncture deep-seated whepatic tumors under standard linear-type laparoscopic ultrasonography. Forward-viewing laparoscopic ultrasonography (End-Fire array), which was recently been developed, enables us to puncture deep-seated HCC exactly. We have performed laparoscopic thermal ablation for 8 HCCs out of 7 patients by using this End-Fire array. Among them, three were treated by microwave coagulation and four were by radiofrequency ablation. Six of 7 patients were completely and easily treated with this array. One patient had multiple HCCs and two relatively large HCCs were ablated for mass reduction. Thus, this new array is useful to perform laparoscopic thermal ablation against deep-seated HCC.

    DOI: 10.3380/jmicrowavesurg.26.85

    CiNii Article

  • Drug-induced liver injury caused by a herbal medicine, bofu-tsu-sho-san

    MOTOYAMA Hiroyuki, ENOMOTO Masaru, YASUDA Takahiro, FUJII Hideki, KOBAYASHI Sawako, IWAI Shuji, MORIKAWA Hiroyasu, TAKEDA Tadashi, TAMORI Akihiro, SAKAGUCHI Hiroki, KAWADA Norifumi

    Nippon Shokakibyo Gakkai Zasshi   105 ( 8 )   1234 - 1239   2008( ISSN:04466586

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    A 37-year-old woman was admitted to a hospital with jaundice. Within a couple of weeks, her liver function improved with only symptomatic therapy. About 30 to 60 days before admission, she had taken a herbal medicine, bofu-tsu-sho-san. A diagnosis of drug-induced liver injury was made according to the diagnostic scale proposed at the Digestive Disease Week-Japan 2004. A drug-lymphocyte stimulation test for each ingredient of bofu-tsu-sho-san; the results were positive for <i>Cnidii Rhizoma</i>, <i>Angelicae Radix</i> and <i>Menthae Herba</i>. The liver biopsy specimen revealed features of acute hepatitis. Physicians should be aware that bofu-tsu-sho-san can cause liver injury, as this drug is commonly used as an over-the-counter medicine.<br>

    DOI: 10.11405/nisshoshi.105.1234

    PubMed

    CiNii Article

  • Plummer-Vinson syndrome successfully treated by endoscopic dilatation Reviewed

    Enomoto Masaru, Kohmoto Madoka, Arafa Usama Ahmed, Shiba Masatsugu, Watanabe Toshio, Tominaga Kazunari, Fujiwara Yasuhiro, Saeki Yoshihiko, Higuchi Kazuhide, Nishiguchi Shuhei, Shiomi Susumu, Osugi Haruji, Kinoshita Hiroaki, Arakawa Tetsuo

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   22 ( 12 )   2348 - 2351   2007.12( ISSN:0815-9319

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    DOI: 10.1111/j.1440-1746.2006.03430.x

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  • Mutational patterns of hepatitis B virus genome and clinical outcomes after emergence of drug-resistant variants during lamivudine therapy: Analyses of the polymerase gene and full-length sequences Reviewed

    Enomoto Masaru, Tamori Akihiro, Kohmoto Madoka Toyama, Morikawa Hiroyasu, Habu Daiki, Sakaguchi Hiroki, Takeda Tadashi, Seki Shuichi, Kawada Norifumi, Shiomi Susumu, Nishiguchi Shuhei

    JOURNAL OF MEDICAL VIROLOGY   79 ( 11 )   1664 - 1670   2007.11( ISSN:0146-6615

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    DOI: 10.1002/jmv.20984

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  • A case of sclerosing cholangitis with autoimmune pancreatitis evaluated by FDG-PET Reviewed

    Kawamura Etsushi, Habu Daiki, Higashiyama Shigeaki, Tsushima Hiroyuki, Shimonishi Yoshihiro, Nakayama Yuji, Enomoto Masaru, Kawabe Joji, Tamori Akihiro, Kawada Norifumi, Shiomi Susumu

    ANNALS OF NUCLEAR MEDICINE   21 ( 4 )   223 - 228   2007.06( ISSN:0914-7187

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s12149-007-0008-0

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  • Expression of connective tissue growth factor in the human liver with idiopathic portal hypertension.

    Morikawa H, Tamori A, Nishiguchi S, Enomoto M, Habu D, Kawada N, Shiomi S

    Molecular medicine (Cambridge, Mass.)   13 ( 5-6 )   240 - 5   2007.05( ISSN:1076-1551

  • Lamivudine and IFN-beta sequential therapy in HBe antigen-positive patients with chronic hepatitis B virus genotype C infection Reviewed

    Enomoto Masaru, Tamori Akihiro, Kohmoto Madoka Toyama, Hayashi Takehiro, Jomura Hisato, Habu Daiki, Sakaguchi Hiroki, Takeda Tadashi, Kawada Norifumi, Seki Shuichi, Shiomi Susumu, Koh Noritoshi, Nishiguchi Shuhei

    JOURNAL OF INTERFERON AND CYTOKINE RESEARCH   27 ( 3 )   201 - 207   2007.03( ISSN:1079-9907

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1089/jir.2006.0140

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  • Development of hepatocellular carcinoma in patients with chronic hepatitis C who had a sustained virological response to interferon therapy: a multicenter, retrospective cohort study of 1124 patients Reviewed

    Kobayashi S., Takeda T., Enomoto M., Tamori A., Kawada N., Habu D., Sakaguchi H., Kuroda T., Kioka K., Kim S. R., Kanno T., Ueda T., Hirano M., Fujimoto S., Jomura H., Nishiguchi S., Seki S.

    LIVER INTERNATIONAL   27 ( 2 )   186 - 191   2007.03( ISSN:1478-3223

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/j.1478-3231.2006.01406.x

  • Development of hepatocellular carcinoma in patients with chronic hepatitis C who had a sustained virological response to interferon therapy: a multicenter, retrospective cohort study of 1124 patients Reviewed

    S. Kobayashi, T. Takeda, M. Enomoto, A. Tamori, N. Kawada, D. Habu, H. Sakaguchi, T. Kuroda, K. Kioka, S. R. Kim, T. Kanno, T. Ueda, M. Hirano, S. Fujimoto, H. Jomura, S. Nishiguchi, S. Seki

    LIVER INTERNATIONAL   27 ( 2 )   186 - 91   2007.03( ISSN:1478-3223

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    Background: Interferon (IFN) improves hepatic inflammation/fibrosis and reduces the risk of hepatocellular carcinoma (HCC) in patients with chronic hepatitis C (CH-C). However, HCC develops in some patients who have a sustained virological response (SVR) to IFN therapy. We designed this study to establish a follow-up protocol for patients with CH-C who have SVR to IFN therapy. Methods: We retrospectively studied 1124 patients with CH-C who received IFN. Results: HCC developed in 3.5% of patients with SVR to IFN. As compared with SVR patients without HCC, SVR patients with HCC were predominantly male (P=0.003), older at the initiation of IFN therapy (P=0.002), and at a more advanced histologic stage of disease (P &lt; 0.001). However, three of the 13 SVR HCC patients had mild fibrosis. The mean interval from IFN therapy to the detection of HCC in SVR HCC patients was 5.8 years and did not differ significantly from that in non-SVR HCC patients (P=0.304). Although most patients with HCC received curative therapy, the prognosis of some SVR HCC patients was poor, probably because of insufficient follow-up, resulting in delayed detection of HCC. Conclusions: SVR patients with CH-C who are elderly, male, or have an advanced histologic stage are at a high risk for the development of HCC after IFN therapy. We recommend that SVR patients should be observed carefully for more than 10 years after the completion of IFN therapy, even if they only have early fibrosis.

    DOI: 10.1111/j.1478-3231.2006.01406.x

    PubMed

  • Thiopurine S-methyltransferase gene polymorphism in Japanese patients with autoimmune liver diseases Reviewed

    Tamori Akihiro, Shinzaki Mayumi, Kosaka Saori, Hayashi Takehiro, Iwai Shuji, Enomoto Masaru, Habu Daiki, Sakaguchi Hiroki, Kawada Norifumi, Hino Masayuki, Shiomi Susumu, Nishiguchi Shuhei

    LIVER INTERNATIONAL   27 ( 1 )   95 - 100   2007.02( ISSN:1478-3223

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    DOI: 10.1111/j.1478-3231.2006.01392.x

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  • Laparoscopic observation of 2 cases of nodular regenerative hyperplasia of the liver Reviewed

    Fujii Hideki, Sakaguchi Hiroki, Enomoto Masaru, Yamamori Kazuki, Inagawa Makoto, Watanabe Toshio, Kawada Norifumi, Seki Shuichi, Arakawa Tetsuo

    GASTROINTESTINAL ENDOSCOPY   65 ( 1 )   171 - 173   2007.01( ISSN:0016-5107

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.gie.2006.08.001

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  • Indication and results of thermal ablation for hepatocellular carcinoma Reviewed

    Sakaguchi Hiroki, Enomoto Masaru, Tamori Akihiro, Takeda Tadashi, Seki Shuichi, Kawada Norifumi, Yasuda Takahiro, Fujii Hideki, Kurooka Hiroko, Kobayashi Sawako, Nakayama Yuji, Iwai Shuji, Kadoya Hirokazu, Morikawa Hiroyasu

    Study Group of Microwave Surgery, Journal of Microwave Surgery   ( 25 )   89 - 91   2007( ISSN:0917-7728

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    We analyzed the rates of survival, non-local recurrence, and non-another recurrence of 89 patients with solitary hepatocellular carcinoma who underwent thermal ablation therapies as primary treatment (naive patients). Thirty five cases were ablated by percutaneous radiofrequency ablation (PRFA), 32 and 22 were treated by laparoscopic microwave coagulation (LMCT) and by percutaneous microwave coagulation (PMCT), respectively. Five-year survival rates were 87%, 60%, and 82% in PRFA, LMCT, and PMCT, respectively, with no statistical significance. Rates of 5-year non-local recurrence were 60%, 74%, and 51% in PRFA, LMCT, and PMCT, respectively, with no statistical significance. Those of 5-year non-another recurrence were 0%, 19%, and 20%, with no statistical significance.Thus, PRFA, LMCT, and PMCT had same effectiveness for the local treatment of HCC.

    DOI: 10.3380/jmicrowavesurg.25.89

    CiNii Article

  • A case of hepatocellular carcinoma successfully treated by percutaneous radiofrequency ablation using the laparoscopic artificial ascites technique Reviewed

    Kobayashi Sawako, Enomoto Masaru, Tamori Akihiro, Habu Daiki, Takeda Tadashi, Kawada Norifumi, Seki Shuichi, Sakaguchi Hiroki, Kotani Jin, Toyama Madoka, Yasuda Takahiro, Fujii Hideki, Kurooka Hiroko, Nakayama Yuji, Iwai Shuji

    Study Group of Microwave Surgery, Journal of Microwave Surgery   ( 25 )   105 - 108   2007( ISSN:0917-7728

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    A 70-year-old man was admitted for suspected hepatocellular carcinoma (HCC). Abdominal CT detected a tumor mass 2.5 cm in diameter protruding from the surface of the right lobe of his liver. We decided to perform radiofrequency ablation (RFA) with laparoscopic guidance. Laparoscopy revealed the HCC being adjacent to the costae on the outermost side of the right lobe; it was difficult to safely puncture an electrode needle into the tumor. Hence, we infused normal saline (artificial ascites) into the space between the liver and abdominal wall, and then performed percutaneous RFA with ultrasonography guidance. Using this laparoscopic artificial ascites technique, we could safely and easily perform ultrasonography-guided percutaneous RFA for HCC on the outermost side of the right lobe of the liver, which is otherwise difficult to treat by laparoscopic or percutaneous approach.

    DOI: 10.3380/jmicrowavesurg.25.105

    CiNii Article

  • A case of hepatocellular carcinoma successfully treated by percutaneous radiofrequency ablation using the laparoscopic artificial ascites technique

    Kobayashi Sawako, Sakaguchi Hiroki, Kotani Jin, Toyama Madoka, Yasuda Takahiro, Fujii Hideki, Kurooka Hiroko, Nakayama Yuji, Iwai Shuji, Enomoto Masaru, Tamori Akihiro, Habu Daiki, Takeda Tadashi, Kawada Norifumi, Seki Shuichi

    Journal of Microwave Surgery   25   105 - 108   2007( ISSN:09177728

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    A 70-year-old man was admitted for suspected hepatocellular carcinoma (HCC). Abdominal CT detected a tumor mass 2.5 cm in diameter protruding from the surface of the right lobe of his liver. We decided to perform radiofrequency ablation (RFA) with laparoscopic guidance. Laparoscopy revealed the HCC being adjacent to the costae on the outermost side of the right lobe; it was difficult to safely puncture an electrode needle into the tumor. Hence, we infused normal saline (artificial ascites) into the space between the liver and abdominal wall, and then performed percutaneous RFA with ultrasonography guidance. Using this laparoscopic artificial ascites technique, we could safely and easily perform ultrasonography-guided percutaneous RFA for HCC on the outermost side of the right lobe of the liver, which is otherwise difficult to treat by laparoscopic or percutaneous approach.

    DOI: 10.3380/jmicrowavesurg.25.105

    CiNii Article

  • Indication and results of thermal ablation for hepatocellular carcinoma

    Sakaguchi Hiroki, Yasuda Takahiro, Fujii Hideki, Kurooka Hiroko, Kobayashi Sawako, Nakayama Yuji, Iwai Shuji, Kadoya Hirokazu, Morikawa Hiroyasu, Enomoto Masaru, Tamori Akihiro, Takeda Tadashi, Seki Shuichi, Kawada Norifumi

    Journal of Microwave Surgery   25   89 - 91   2007( ISSN:09177728

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    We analyzed the rates of survival, non-local recurrence, and non-another recurrence of 89 patients with solitary hepatocellular carcinoma who underwent thermal ablation therapies as primary treatment (naive patients). Thirty five cases were ablated by percutaneous radiofrequency ablation (PRFA), 32 and 22 were treated by laparoscopic microwave coagulation (LMCT) and by percutaneous microwave coagulation (PMCT), respectively. Five-year survival rates were 87%, 60%, and 82% in PRFA, LMCT, and PMCT, respectively, with no statistical significance. Rates of 5-year non-local recurrence were 60%, 74%, and 51% in PRFA, LMCT, and PMCT, respectively, with no statistical significance. Those of 5-year non-another recurrence were 0%, 19%, and 20%, with no statistical significance.Thus, PRFA, LMCT, and PMCT had same effectiveness for the local treatment of HCC.

    DOI: 10.3380/jmicrowavesurg.25.89

    CiNii Article

  • Alteration of gene expression by hepatitis B virus DNA integration in human hepatocellular carcinoma Reviewed

    Tamori Akihiro, Yamanishi Yoshihisa, Kawashima Shuichi, Kanehisa Minoru, Enomoto Masaru, Habu Daiki, Tanaka Hiromu, Kubo Shoji, Shiomi Susumu, Nishiguchi Shuhei

    CANCER RESEARCH   66 ( 8 )   2006.04( ISSN:0008-5472

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  • Alteration of gene expression by hepatitis B virus DNA integration in human hepatocellular carcinoma Reviewed

    Tamori Akihiro, Yamanishi Yoshihisa, Kawashima Shuichi, Kanehisa Minoru, Enomoto Masaru, Habu Daiki, Tanaka Hiromu, Kubo Shoji, Shiomi Susumu, Nishiguchi Shuhei

    CANCER RESEARCH   66 ( 8 )   2006.04( ISSN:0008-5472

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  • Interferon-beta plus ribavirin for patients with hepatitis C virus genotype 1: a randomised pilot trial Reviewed

    Enomoto M, Tamori A, Kawada N, Jomura H, Nishiguchi S, Saibara T, Onishi S, Mochida S, Fujiwara K

    GUT   55 ( 1 )   139 - 140   2006.01( ISSN:0017-5749

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    DOI: 10.1136/gut.2005.081935

  • Hepatitis B virus genotypes and response to antiviral therapy. Reviewed

    Enomoto M, Tamori A, Nishiguchi S

    Clinical laboratory   52 ( 1-2 )   43 - 7   2006( ISSN:1433-6510

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    PubMed

  • Indication and results of thermal ablation therapies for hepatocellular carcinoma Reviewed

    Sakaguchi Hiroki, Enomoto Masaru, Tamori Akihiro, Habu Daiki, Takeda Tadashi, Kawada Norifumi, Seki Shuichi, Hagihara Atsushi, Toyama Madoka, Yasuda Takahiro, Fujii Hideki, Kobayashi Sawako, Nakayama Yuji, Iwai Shuji, Kadoya Hirokazu

    Study Group of Microwave Surgery, Journal of Microwave Surgery   ( 24 )   87 - 89   2006( ISSN:0917-7728

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    We analyzed the survival rates, local recurrence rates, and another recurrence rates for patients with solitary hepatocellular carcinoma who received thermal ablation therapies as primary treatment (naive patients). In these 89 patients, 35 cases were ablated by percutaneous radiofrequency ablation (PRFA), 32 were treated by laparoscopic microwave coagulation (LMCT), and 22 were treated by percutaneous microwave coagulation (PMCT). 5-year survival rates were 87% in PRFA, 56% in LMCT, 76% in PMCT. The differences of survival rates were not statistically significant among PRFA, LMCT, and PMCT. 5-year local recurrence rates were 49%, 26%, and 44%, consecutively. No differences were found between therapies. 5-year another recurrence rates were 100%, 81%, and 80%, consecutively. No differences were found statistically.

    DOI: 10.3380/jmicrowavesurg.24.87

    CiNii Article

  • Indication and results of thermal ablation therapies for hepatocellular carcinoma

    Sakaguchi Hiroki, Hagihara Atsushi, Toyama Madoka, Yasuda Takahiro, Fujii Hideki, Kobayashi Sawako, Nakayama Yuji, Iwai Shuji, Kadoya Hirokazu, Enomoto Masaru, Tamori Akihiro, Habu Daiki, Takeda Tadashi, Kawada Norifumi, Seki Shuichi

    Journal of Microwave Surgery   24   87 - 89   2006( ISSN:09177728

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    We analyzed the survival rates, local recurrence rates, and another recurrence rates for patients with solitary hepatocellular carcinoma who received thermal ablation therapies as primary treatment (naive patients). In these 89 patients, 35 cases were ablated by percutaneous radiofrequency ablation (PRFA), 32 were treated by laparoscopic microwave coagulation (LMCT), and 22 were treated by percutaneous microwave coagulation (PMCT). 5-year survival rates were 87% in PRFA, 56% in LMCT, 76% in PMCT. The differences of survival rates were not statistically significant among PRFA, LMCT, and PMCT. 5-year local recurrence rates were 49%, 26%, and 44%, consecutively. No differences were found between therapies. 5-year another recurrence rates were 100%, 81%, and 80%, consecutively. No differences were found statistically.

    DOI: 10.3380/jmicrowavesurg.24.87

    CiNii Article

  • Hepatitis B virus genotypes and response to antiviral therapy.

    Enomoto M, Tamori A, Nishiguchi S

    Clinical laboratory   52 ( 1-2 )   43 - 7   2006( ISSN:1433-6510

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  • Ultrasonographic diagnosis of degree of chronic type C liver disease. Reviewed

    Habu D, Nishiguchi S, Enomoto M, Nakatani S, Minamitani S, Tamori A, Sakaguchi H, Takeda T, Seki S, Ogami M, Asai H, Shiomi S

    Hepato-gastroenterology   52 ( 66 )   1820 - 4   2005.11( ISSN:0172-6390

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    PubMed

  • Ultrasonographic diagnosis of degree of chronic type C liver disease.

    Habu D, Nishiguchi S, Enomoto M, Nakatani S, Minamitani S, Tamori A, Sakaguchi H, Takeda T, Seki S, Ogami M, Asai H, Shiomi S

    Hepato-gastroenterology   52 ( 66 )   1820 - 4   2005.11( ISSN:0172-6390

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  • Chemiluminescence enzyme immunoassay for monitoring hepatitis C virus core protein during interferon-alpha 2b and ribavirin therapy in patients with genotype 1 and high viral loads Reviewed

    Enomoto M, Nishiguchi S, Tamori A, Kohmoto M, Habu D, Sakaguchi H, Takeda T, Kawada N, Seki S, Shiomi S

    JOURNAL OF MEDICAL VIROLOGY   77 ( 1 )   77 - 82   2005.09( ISSN:0146-6615

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    DOI: 10.1002/jmv.20416

    PubMed

  • Alteration of gene expression in human hepatocellular carcinoma with integrated hepatitis B virus DNA Reviewed

    Tamori A, Yamanishi Y, Kawashima S, Kanehisa M, Enomoto M, Tanaka H, Kubo S, Shiomi S, Nishiguchi S

    CLINICAL CANCER RESEARCH   11 ( 16 )   5821 - 5826   2005.08( ISSN:1078-0432

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    DOI: 10.1158/1078-0432.CCR-04-2055

    PubMed

  • Alcohol abuse as an etiologic factor for hepatocellular carcinoma in Japan Reviewed

    Kubo S, Oba K, Hirohashi K, Tanaka H, Shuto T, Takemura S, Yamamoto T, Tamori A, Enomoto M, Nishiguchi S

    HEPATOLOGY RESEARCH   31 ( 2 )   73 - 78   2005.02( ISSN:1386-6346

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    DOI: 10.1016/j.hepres.2004.09.008

    PubMed

  • Quantitative detection of hepatitis B surface antigen by chemiluminescent microparticle immunoassay during lamivudine treatment of chronic hepatitis B virus carriers. Reviewed

    Kohmoto M, Enomoto M, Tamori A, Habu D, Takeda T, Kawada N, Sakaguchi H, Seki S, Shiomi S, Nishiguchi S

    Journal of medical virology   75 ( 2 )   235 - 9   2005.02( ISSN:0146-6615

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    DOI: 10.1002/jmv.20262

    PubMed

  • Prognostic factors for survival of patients with hepatocellular carcinoma treated by laparoscopic microwave coagulation therapy Reviewed

    Sakaguchi Hiroki, Enomoto Masaru, Tamori Akihiro, Habu Daiki, Takeda Tadashi, Kawada Norifumi, Seki Shuichi, Hagihara Atsushi, Toyama Madoka, Yasuda Takahiro, Fujii Hideki, Kobayashi Sawako, Nakayama Yuji, Iwai Shuji, Kodoya Hirokazu

    Study Group of Microwave Surgery, Journal of Microwave Surgery   ( 23 )   31 - 34   2005( ISSN:0917-7728

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    68 patients with hepatocellular carcinoma were treated with laparoscopic microwave coagulation therapy between April 1995 and February 2003 at our institution. For these 68 case, we analyzed prognostic factors contributing to survival with univariate and multivariate analysis. When the survival rate was assessed for all patients treated with laparoscopic microwave coagulation, one-year survival was 97%, three-year survival was 81%, and five-year survival was 43%. On univariate analysis, only histology was a significant factor for survival. And on multivariate analysis, whether the therapy was primary or secondary HCC strongly influenced survival.

    DOI: 10.3380/jmicrowavesurg.23.31

    CiNii Article

  • Prognostic factors for survival of patients with hepatocellular carcinoma treated by laparoscopic microwave coagulation therapy

    Sakaguchi Hiroki, Hagihara Atsushi, Toyama Madoka, Yasuda Takahiro, Fujii Hideki, Kobayashi Sawako, Nakayama Yuji, Iwai Shuji, Kodoya Hirokazu, Enomoto Masaru, Tamori Akihiro, Habu Daiki, Takeda Tadashi, Kawada Norifumi, Seki Shuichi

    Journal of Microwave Surgery   23   31 - 34   2005( ISSN:09177728

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    68 patients with hepatocellular carcinoma were treated with laparoscopic microwave coagulation therapy between April 1995 and February 2003 at our institution. For these 68 case, we analyzed prognostic factors contributing to survival with univariate and multivariate analysis. When the survival rate was assessed for all patients treated with laparoscopic microwave coagulation, one-year survival was 97%, three-year survival was 81%, and five-year survival was 43%. On univariate analysis, only histology was a significant factor for survival. And on multivariate analysis, whether the therapy was primary or secondary HCC strongly influenced survival.

    DOI: 10.3380/jmicrowavesurg.23.31

    CiNii Article

  • Adefovir dipivoxil to prevent exacerbation of lamivudine-resistant hepatitis B infection during chemotherapy for non-Hodgkin's lymphoma

    Am J Gastroenterol   99 ( 8 )   1619 - 20   2004

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  • SEN viruses and treatment response in chronic hepatitis C virus.

    Lancet   359 ( 9319 )   1780 - 1   2002

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  • Changes in serum levels of hepatitis C virus genotype 1b monitored by real-time quantitative polymerase chain reaction as a predictor of long term response to interferon-alpha treatment.

    Am J Gastroenterol   97 ( 2 )   420 - 6   2002

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MISC

  • 【肝疾患-診療のチェックポイント2023】(第II部)治療のチェックポイント(第2章) 慢性肝炎薬物療法のチェックポイント B型慢性肝炎の治療目標

    榎本 大

    臨床消化器内科   38 ( 7 )   867 - 871   2023.06( ISSN:0911-601X

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    <文献概要>▼日本肝臓学会の「B型肝炎治療ガイドライン」では,HBV持続感染者における抗ウイルス治療の長期目標は"HBs抗原消失"である.▼HBs抗原消失に至るまでの抗ウイルス治療の短期目標は,ALT持続正常化(30U/l以下),HBe抗原陰性,HBV-DNA増殖抑制の3項目である.

  • Hepatocelluar Carcinoma Risk in Advanced Fibrosis After Sustained Virologic Response: When Can We Safely Stop Hepatocellular Carcinoma Surveillance?

    Enomoto M.

    Hepatology Communications   6 ( 3 )   445 - 447   2022.03

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  • 歯科の先生方にも知っておいて頂きたいB型・C型肝炎最新情報

    榎本 大

    大阪府歯科医師会雑誌   ( 772 )   32 - 45   2021.01( ISSN:0912-2672

  • 【B型肝炎の再活性化:現状と撲滅に向けた対策】HBV再活性化対策のため介入投与された核酸アナログは中止可能か Reviewed

    田守 昭博, 榎本 大, 河田 則文

    (一社)日本肝臓学会 肝臓   61 ( 5 )   244 - 244   2020.05( ISSN:0451-4203

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  • 【B型肝炎の再活性化:現状と撲滅に向けた対策】HBV再活性化対策のため介入投与された核酸アナログは中止可能か

    田守 昭博, 榎本 大, 河田 則文

    肝臓   61 ( 5 )   244 - 244   2020.05( ISSN:0451-4203

  • 【Post SVR時代の門脈圧亢進症】SVR後門脈圧亢進症の臨床像 門脈圧亢進症症例に対するDAAの選択

    榎本 大, 田守 昭博, 河田 則文

    肝胆膵   80 ( 5 )   809 - 815   2020.05( ISSN:0389-4991

  • DO HEPATOLOGISTS FOLLOW-UP LOW REPLICATIVE HEPATITIS B VIRUS INACTIVE CARRIERS EFFECTIVELY? A MULTI-CENTER STUDY WITH 2,640 HBV PATIENTS IDENTIFIED AT THEIR INITIAL VISITS Reviewed

    Matono Tomomitsu, Isomoto Hajime, Inoue Takako, Tanaka Yasuhito, Ishigami Masatoshi, Suetsugu Atsushi, Enomoto Masaru, Sato Syuuichi, Sakai Akito, Hidaka Isao, Ogawa Koji, Inoue Jun, Kondo Yasuteru, Ide Tatsuya, Kakizaki Satoru, Kobayashi Yoshimasa, Genda Takuya, Korenaga Masaaki

    HEPATOLOGY   70   588A - 588A   2019.10( ISSN:0270-9139

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  • TENOFOVIR VERSUS ENTECAVIR FOR HEPATOCELLULAR CARCINOMA PREVENTION IN AN INTERNATIONAL CONSORTIUM OF CHRONIC HEPATITIS B Reviewed

    Hsu Yao-Chun, Wong Grace Lai-Hung, Chen Chien Hung, Peng Cheng-Yuan, Yeh Ming-Lun, Cheung Ka-Shing, Toyoda Hidenori, Huang Chung-Feng, Trinh Huy N., Xie Qing, Enomoto Masaru, Liu Li, Yasuda Satoshi, Tanaka Yasuhito, Kozuka Ritsuzo, Tsai Pei-Chien, Huang Yen-Tsung, Wong Christopher, Huang Rui, Jang Tyng-Yuan, Hoang Joseph, Yang Hwai-I, Li Jiayi, Lee Dong Hyun, Takahashi Hirokazu, Zhang Jianqing, Ogawa Eiichi, Zhao Changqing, Liu Chenghai, Furusyo Norihiro, Eguchi Yuichiro, Wong Clifford, Wu Chao, Kumada Takashi, Yuen Man-Fung, Yu Ming-Lung, Nguyen Mindie H.

    HEPATOLOGY   70   290A - 291A   2019.10( ISSN:0270-9139

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  • IMPACT OF SVR ON LONG-TERM LIVER-RELATED OUTCOMES: RESULTS OF THE REAL-C REGISTRY AT 23 CENTERS FROM HONG KONG, KOREA, JAPAN AND TAIWAN Reviewed

    Tanaka Yasuhito, Toyoda Hidenori, Jun Dae Won, Enomoto Masaru, Huang Chung-Feng, Ogawa Eiichi, Yasuda Satoshi, Iio Etsuko, Iwane Shinji, Haga Hiroaki, Dai Chia-Yen, Jeong Jae Yoon, Park Seung Ha, Wong Grace L., Lee Dong Hyun, Takahashi Hirokazu, Huang Jee-Fu, Tran Sally, Maeda Mayumi, Cheung Ramsey, Ueno Yoshiyuki, Eguchi Yuichiro, Hayashi Jun, Furusyo Norihiro, Tamori Akihiro, Kumada Takashi, Yu Ming-Lung, Nguyen Mindie H., Ahn Sang Bong, Henry Linda, Hsu Yao-Chun, Huang Ching-I, Jun Mi Jung, Jung Jang Han, Kam Leslie, Lee Mei-Hsuan, Liang Po-Cheng, Mizuta Akiko, Song Do Seon, Tsai Pei-Chien, Tseng Cheng-Hao, Yang Hwai-I, Yeh Ming-Lun, Yoon Eileen

    HEPATOLOGY   70   908A - 909A   2019.10( ISSN:0270-9139

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  • HCV CURE BY ALL ORAL DAA IMPROVES 5-YEAR OVERALL AND LIVER-RELATED SURVIVAL IN HCV-RELATED HCC PATIENTS: A REAL-WORLD, PROPENSITY SCORE-MATCHED STUDY FROM BOTH EAST AND WEST Reviewed

    Dang Hansen, Yeo Yee Hui, Yasuda Satoshi, Huang Chung-Feng, Iio Etsuko, Landis Charles S., Jun Dae Won, Enomoto Masaru, Ogawa Eiichi, Tsai Pei-Chien, Le An, Liu Matthew, Maeda Mayumi, Nguyen Brian, Ramrakhiani Nathan, Henry Linda, Cheung Ramsey, Tamori Akihiro, Kumada Takashi, Tanaka Yasuhito, Yu Ming-Lung, Toyoda Hidenori, Nguyen Mindie H.

    HEPATOLOGY   70   28A - 28A   2019.10( ISSN:0270-9139

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  • DO HEPATOLOGISTS FOLLOW-UP LOW REPLICATIVE HEPATITIS B VIRUS INACTIVE CARRIERS EFFECTIVELY? A MULTI-CENTER STUDY WITH 2,640 HBV PATIENTS IDENTIFIED AT THEIR INITIAL VISITS Reviewed

    Matono Tomomitsu, Isomoto Hajime, Inoue Takako, Tanaka Yasuhito, Ishigami Masatoshi, Suetsugu Atsushi, Enomoto Masaru, Sato Syuuichi, Sakai Akito, Hidaka Isao, Ogawa Koji, Inoue Jun, Kondo Yasuteru, Ide Tatsuya, Kakizaki Satoru, Kobayashi Yoshimasa, Genda Takuya, Korenaga Masaaki

    HEPATOLOGY   70   588A - 588A   2019.10( ISSN:0270-9139

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    Publishing type:Research paper, summary (international conference)  

  • TENOFOVIR VERSUS ENTECAVIR FOR HEPATOCELLULAR CARCINOMA PREVENTION IN AN INTERNATIONAL CONSORTIUM OF CHRONIC HEPATITIS B Reviewed

    Hsu Yao-Chun, Wong Grace Lai-Hung, Chen Chien Hung, Peng Cheng-Yuan, Yeh Ming-Lun, Cheung Ka-Shing, Toyoda Hidenori, Huang Chung-Feng, Trinh Huy N, Xie Qing, Enomoto Masaru, Liu Li, Yasuda Satoshi, Tanaka Yasuhito, Kozuka Ritsuzo, Tsai Pei-Chien, Huang Yen-Tsung, Wong Christopher, Huang Rui, Jang Tyng-Yuan, Hoang Joseph, Yang Hwai-I, Li Jiayi, Lee Dong Hyun, Takahashi Hirokazu, Zhang Jianqing, Ogawa Eiichi, Zhao Changqing, Liu Chenghai, Furusyo Norihiro, Eguchi Yuichiro, Wong Clifford, Wu Chao

    HEPATOLOGY   70   290A - 291A   2019.10( ISSN:0270-9139

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  • IMPACT OF SVR ON LONG-TERM LIVER-RELATED OUTCOMES: RESULTS OF THE REAL-C REGISTRY AT 23 CENTERS FROM HONG KONG, KOREA, JAPAN AND TAIWAN Reviewed

    Tanaka Yasuhito, Toyoda Hidenori, Jun Dae Won, Enomoto Masaru, Huang Chung-Feng, Ogawa Eiichi, Yasuda Satoshi, Iio Etsuko, Iwane Shinji, Haga Hiroaki, Dai Chia-Yen, Jeong Jae Yoon, Park Seung Ha, Wong Grace L, Lee Dong Hyun, Takahashi Hirokazu, Huang Jee-Fu, Tran Sally, Maeda Mayumi, Cheung Ramsey, Ueno Yoshiyuki, Eguchi Yuichiro, Hayashi Jun, Furusyo Norihiro, Tamori Akihiro, Kumada Takashi, Yu Ming-Lung, Nguyen Mindie H, Ahn Sang Bong, Henry Linda, Hsu Yao-Chun, Huang Ching-I, Jun Mi Jung, J

    HEPATOLOGY   70   908A - 909A   2019.10( ISSN:0270-9139

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  • HCV CURE BY ALL ORAL DAA IMPROVES 5-YEAR OVERALL AND LIVER-RELATED SURVIVAL IN HCV-RELATED HCC PATIENTS: A REAL-WORLD, PROPENSITY SCORE-MATCHED STUDY FROM BOTH EAST AND WEST Reviewed

    Dang Hansen, Yeo Yee Hui, Yasuda Satoshi, Huang Chung-Feng, Iio Etsuko, Landis Charles S, Jun Dae Won, Enomoto Masaru, Ogawa Eiichi, Tsai Pei-Chien, Le An, Liu Matthew, Maeda Mayumi, Nguyen Brian, Ramrakhiani Nathan, Henry Linda, Cheung Ramsey, Tamori Akihiro, Kumada Takashi, Tanaka Yasuhito, Yu Ming-Lung, Toyoda Hidenori, Nguyen Mindie H

    HEPATOLOGY   70   28A - 28A   2019.10( ISSN:0270-9139

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  • 【肝臓病学の未来-ウイルス性肝炎から脂肪肝と肝がんの時代へ】C型肝炎 HCV排除は肝がんを抑制するのか 外来でのフォローはどうするか Reviewed

    榎本 大, 伊倉 義弘, 田守 昭博, 河田 則文

    (株)南江堂 内科   123 ( 5 )   1081 - 1085   2019.05( ISSN:0022-1961

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    <文献概要>Summary ▼直接作動型抗ウイルス薬(DAA)の登場により,インターフェロン(IFN)が適用できなかった高齢者または肝線維化進展例でもHCV排除が可能になった.▼年齢や観察期間などの背景因子を調整したメタ解析では,DAA治療でもIFN治療と同等に,SVR獲得により肝発がん(または肝がん再発)を抑制できることが示された.▼エラストグラフィなどの非侵襲的診断法により,DAA治療による肝線維化の改善も示唆されている.自験例では治療前後の肝生検により,病理組織学的な肝内の壊死・炎症,鉄沈着の改善が示された.▼一方,HCVが排除されても肝発がんは完全には抑制されない.そのため肝発がんに対するフォローアップを継続する必要があり,具体的なサーベイランスの方法を確立することが課題である.

  • 【肝臓病学の未来-ウイルス性肝炎から脂肪肝と肝がんの時代へ】C型肝炎 HCV排除は肝がんを抑制するのか 外来でのフォローはどうするか

    榎本 大, 伊倉 義弘, 田守 昭博, 河田 則文

    内科   123 ( 5 )   1081 - 1085   2019.05( ISSN:0022-1961

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    <文献概要>Summary ▼直接作動型抗ウイルス薬(DAA)の登場により,インターフェロン(IFN)が適用できなかった高齢者または肝線維化進展例でもHCV排除が可能になった.▼年齢や観察期間などの背景因子を調整したメタ解析では,DAA治療でもIFN治療と同等に,SVR獲得により肝発がん(または肝がん再発)を抑制できることが示された.▼エラストグラフィなどの非侵襲的診断法により,DAA治療による肝線維化の改善も示唆されている.自験例では治療前後の肝生検により,病理組織学的な肝内の壊死・炎症,鉄沈着の改善が示された.▼一方,HCVが排除されても肝発がんは完全には抑制されない.そのため肝発がんに対するフォローアップを継続する必要があり,具体的なサーベイランスの方法を確立することが課題である.

  • Prospective multicenter study of glecaprevir plus pibrentasvir combination therapy for patients with chronic hepatitis C Reviewed

    Tamori Akihiro, Iwasa Motoo, Inoue Kazuaki, Kagawa Tatehiro, Takaguchi Koichi, Minami Masahito, Iwasaki Yoshiaki, Nouso Kazuhiro, Hoang Hai, Enomoto Masaru, Kawada Norifumi

    JOURNAL OF HEPATOLOGY   70 ( 1 )   E242 - E243   2019.04( ISSN:0168-8278

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  • Prospective multicenter study of glecaprevir plus pibrentasvir combination therapy for patients with chronic hepatitis C Reviewed

    Tamori Akihiro, Iwasa Motoo, Inoue Kazuaki, Kagawa Tatehiro, Takaguchi Koichi, Minami Masahito, Iwasaki Yoshiaki, Nouso Kazuhiro, Hoang Hai, Enomoto Masaru, Kawada Norifumi

    JOURNAL OF HEPATOLOGY   70 ( 1 )   E242 - E243   2019.04( ISSN:0168-8278

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  • "Normal" ALT By Central Laboratory Criteria but > 30 U/L for Males and > 19 U/L for Females Is Predictive of Residual Inflammation in Liver Biopsies after Sustained Virologic Response to Direct-Acting Antivirals for Chronic Hepatitis C Reviewed

    Enomoto Masaru, Ikura Yoshihiro, Tamoril Akihiro, Kozuka Ritsuzo, Motoyama Hiroyuki, Kawamura Etsushi, Hagihara Atsushi, Fujii Hideki, Uchida Sawako, Morikawa Hiroyasu, Murakami Yoshiki, Kawada Norifumi

    HEPATOLOGY   68   907A - 908A   2018.10( ISSN:0270-9139

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  • Safety and Efficacy of Glecaprevir Plus Pibrentasvir Combination Therapy for Patients with Chronic Hepatitis C Virus in Real World, Multicenter Study Reviewed

    Tamori Akihiro, Inoue Kazuaki, Iwasa Motoh, Nouso Kazuhiro, Minami Masahito, Kagawa Tatehiro, Uchida Sawako, Enomoto Masaru, Kawada Norifumi

    HEPATOLOGY   68   420A - 421A   2018.10( ISSN:0270-9139

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    Publishing type:Research paper, summary (international conference)  

  • Real-World Experience of All-Oral Directly Acting Antivirals in Asian Chronic Hepatitis C Patients-Real-World Evidence from the Asia Liver Consortium for HCV (REAL-C) Reviewed

    Huang Chung-Feng, Iio Etsuko, Jun Dae Won, Ogawa Eiichi, Haga Hiroaki, Enomoto Masaru, Iwane Shinji, Liu Chen-Hua, Lee Dong Hyun, Takahashi Hirokazu, Wong Grace L. H., Yang Hwai-I, Hayashi Jun, Nomura Hideyuki, Nakamuta Makoto, Dai Chia-Yen, Huang Jee-Fu, Jun Mi Jung, Lee Mei-Hsuan, Tran Sally, Henry Linda, Kao Jia-Horng, Eguchi Yuichiro, Tamori Akihiro, Ueno Yoshiyuki, Tanaka Yasuhito, Furusyo Norihiro, Yu Ming-Lung, Nguyen Mindie H., Ahn Sang Bong, Azuma Koichi, Chuang Wan-Long, Dohmen Kazufumi, Jeong Jae Yoon, Jung Jang Han, Kajiwara Eiji Sr., Kato Masaki, Kawano Akira, Koyanagi Toshimasa, Ooho Aritsune, Park Seung Ha, Satoh Takeaki, Shimoda Shinji, Song Do Seon, Takahashi Kazuhiro, Yeh Ming-Lun, Yoon Eileen

    HEPATOLOGY   68   421A - 422A   2018.10( ISSN:0270-9139

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  • Novel Candidate Drugs That Target Cccdna of HBV Reviewed

    Murakami Yoshiki, Hayakawa Michiyo, Itami-Matsumoto Saari, Ando Mari, Yata Yutaka, Enomoto Masaru, Tamori Akihiro, Kawada Norifumi, Honda Takashi, Yano Yoshihiko, Iwadate Mitsuo, Umeyama Hideaki

    HEPATOLOGY   68   243A - 244A   2018.10( ISSN:0270-9139

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  • Establishing Efficient Systems through Electronic Medical Records to Promote Intra-Hospital Referrals of Hepatitis Virus Carriers to Hepatology Specialists: A Multicenter Questionnaire Survey of 1,314 Healthcare Reviewed

    Enomoto Masaru, Sato Shuichi, Suetsugu Atsushi, Matono Tomomitsu, Hidaka Isao, Sakamoto Minoru, Horino Mika, Ito Kiyoaki, Ogawa Koji, Inoue Jun, Korenaga Masaaki

    HEPATOLOGY   68   279A - 279A   2018.10( ISSN:0270-9139

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  • Effectiveness and Safety of DAA Treatment for Chronic Hepatitis C Patients with Previous Hepatocellular Carcinoma: Results from a Real-World, Multicenter Study of Asian Countries Reviewed

    Ogawa Eiichi, Iio Etsuko, Jun Dae Won, Huang Chung-Feng, Haga Hiroaki, Enomoto Masaru, Iwane Shinji, Lee Dong Hyun, Takahashi Hirokazu, Wong Grace L. H., Yang Hwai-I, Hayashi Jun, Nomura Hideyuki, Nakamuta Makoto, Dai Chia-Yen, Huang Jee-Fu, Jun Mi Jung, Lee Mei-Hsuan, Tran Sally, Henry Linda, Eguchi Yuichiro, Tamori Akihiro, Ueno Yoshiyuki, Yu Ming-Lung, Tanaka Yasuhito, Furusyo Norihiro, Nguyen Mindie H., Ahn Sang Bong, Azuma Koichi, Chuang Wan-Long, Dohmen Kazufumi, Jeong Jae Yoon, Jung Jang Han, Kajiwara Eiji Sr., Kato Masaki, Kawano Akira, Koyanagi Toshimasa, Ooho Aritsune, Park Seung Ha, Satoh Takeaki, Shimoda Shinji, Song Do Seon, Takahashi Kazuhiro, Yeh Ming-Lun, Yoon Eileen

    HEPATOLOGY   68   34A - 35A   2018.10( ISSN:0270-9139

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  • Effectiveness and Safety of DAA Treatment for Chronic Hepatitis C Patients with Previous Hepatocellular Carcinoma: Results from a Real-World, Multicenter Study of Asian Countries Reviewed

    Ogawa Eiichi, Iio Etsuko, Jun Dae Won, Huang Chung-Feng, Haga Hiroaki, Enomoto Masaru, Iwane Shinji, Lee Dong Hyun, Takahashi Hirokazu, Wong Grace L. H, Yang Hwai-I, Hayashi Jun, Nomura Hideyuki, Nakamuta Makoto, Dai Chia-Yen, Huang Jee-Fu, Jun Mi Jung, Lee Mei-Hsuan, Tran Sally, Henry Linda, Eguchi Yuichiro, Tamori Akihiro, Ueno Yoshiyuki, Yu Ming-Lung, Tanaka Yasuhito, Furusyo Norihiro, Nguyen Mindie H, Ahn Sang Bong, Azuma Koichi, Chuang Wan-Long, Dohmen Kazufumi, Jeong Jae Yoon, Jung Jang

    HEPATOLOGY   68   34A - 35A   2018.10( ISSN:0270-9139

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  • Safety and Efficacy of Glecaprevir Plus Pibrentasvir Combination Therapy for Patients with Chronic Hepatitis C Virus in Real World, Multicenter Study Reviewed

    Tamori Akihiro, Inoue Kazuaki, Iwasa Motoh, Nouso Kazuhiro, Minami Masahito, Kagawa Tatehiro, Uchida Sawako, Enomoto Masaru, Kawada Norifumi

    HEPATOLOGY   68   420A - 421A   2018.10( ISSN:0270-9139

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  • Real-World Experience of All-Oral Directly Acting Antivirals in Asian Chronic Hepatitis C Patients-Real-World Evidence from the Asia Liver Consortium for HCV (REAL-C) Reviewed

    Huang Chung-Feng, Iio Etsuko, Jun Dae Won, Ogawa Eiichi, Haga Hiroaki, Enomoto Masaru, Iwane Shinji, Liu Chen-Hua, Lee Dong Hyun, Takahashi Hirokazu, Wong Grace L. H, Yang Hwai-I, Hayashi Jun, Nomura Hideyuki, Nakamuta Makoto, Dai Chia-Yen, Huang Jee-Fu, Jun Mi Jung, Lee Mei-Hsuan, Tran Sally, Henry Linda, Kao Jia-Horng, Eguchi Yuichiro, Tamori Akihiro, Ueno Yoshiyuki, Tanaka Yasuhito, Furusyo Norihiro, Yu Ming-Lung, Nguyen Mindie H, Ahn Sang Bong, Azuma Koichi, Chuang Wan-Long, Dohmen Kazufum

    HEPATOLOGY   68   421A - 422A   2018.10( ISSN:0270-9139

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    Publishing type:Research paper, summary (international conference)  

  • Novel Candidate Drugs That Target Cccdna of HBV Reviewed

    Murakami Yoshiki, Hayakawa Michiyo, Itami-Matsumoto Saari, Ando Mari, Yata Yutaka, Enomoto Masaru, Tamori Akihiro, Kawada Norifumi, Honda Takashi, Yano Yoshihiko, Iwadate Mitsuo, Umeyama Hideaki

    HEPATOLOGY   68   243A - 244A   2018.10( ISSN:0270-9139

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    Publishing type:Research paper, summary (international conference)  

  • Establishing Efficient Systems through Electronic Medical Records to Promote Intra-Hospital Referrals of Hepatitis Virus Carriers to Hepatology Specialists: A Multicenter Questionnaire Survey of 1,314 Healthcare Reviewed

    Enomoto Masaru, Sato Shuichi, Suetsugu Atsushi, Matono Tomomitsu, Hidaka Isao, Sakamoto Minoru, Horino Mika, Ito Kiyoaki, Ogawa Koji, Inoue Jun, Korenaga Masaaki

    HEPATOLOGY   68   279A - 279A   2018.10( ISSN:0270-9139

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    Publishing type:Research paper, summary (international conference)  

  • Sustained virologic response (SVR) to direct-acting antiviral (DAA) therapy in patients with chronic hepatitis C virus (HCV) infection and hepatocellular carcinoma (HCC): a systematic review and meta-analysis Reviewed

    Ji F., Wei M. T., Yeo Y. H., Wei B., Ogawa E., Lee D. H., Enomoto M., Toyoda H., Bass M. B., Lubel J., Ide T., Preda C. M., Iio E., Conti F., Minami T., Bielen R., Sezaki H., Barone M., Chu P. -S., Virlogeux V., Eurich D., Kanai T., Dang S., Li Z., Furusyo N., Zoulim F., Andreone P., Cheung R. C., Tanaka Y., Tamori A., Nguyen M.

    JOURNAL OF HEPATOLOGY   68   S259 - S260   2018.04( ISSN:0168-8278

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  • Monitoring patients with a resolved hepatitis B virus infection for HBV reactivation Reviewed

    Tamori A., Kozuka R., Motoyama H., Fujii H., Hagihara A., Uchida-Kobayashi S., Morikawa H., Enomoto M., Murakami Y., Kawada N.

    JOURNAL OF HEPATOLOGY   68   S478 - S478   2018.04( ISSN:0168-8278

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  • 【肝癌撲滅に向けたわが国の取り組み-厚労省、地方自治体、拠点病院の連携】大阪府の取り組み 医療従事者への啓発 Reviewed

    榎本 大, 打田 佐和子, 藤井 英樹, 河田 則文

    (有)科学評論社 消化器・肝臓内科   3 ( 3 )   324 - 329   2018.03( ISSN:2432-3446

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  • 【肝癌撲滅に向けたわが国の取り組み-厚労省、地方自治体、拠点病院の連携】大阪府の取り組み 医療従事者への啓発

    榎本 大, 打田 佐和子, 藤井 英樹, 河田 則文

    消化器・肝臓内科   3 ( 3 )   324 - 329   2018.03( ISSN:2432-3446

  • C型肝炎に対する抗ウイルス治療の進歩と門脈圧亢進症 Reviewed

    榎本 大, 河田 則文

    (一社)日本門脈圧亢進症学会 日本門脈圧亢進症学会雑誌   23 ( 2 )   149 - 154   2017.07( ISSN:1344-8447

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  • C型肝炎に対する抗ウイルス治療の進歩と門脈圧亢進症

    榎本 大, 河田 則文

    日本門脈圧亢進症学会雑誌   23 ( 2 )   149 - 154   2017.07( ISSN:1344-8447

  • 【ウイルス肝炎 実地診療に活用したいウイルス肝炎の最新情報】セミナー 実地診療に活用したいウイルス肝炎の最新情報 抗ウイルス治療中のB型肝炎における発癌リスク Reviewed

    榎本 大, 河田 則文

    (株)文光堂 Medical Practice   34 ( 5 )   761 - 766   2017.05( ISSN:0910-1551

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  • 【ウイルス肝炎 実地診療に活用したいウイルス肝炎の最新情報】セミナー 実地診療に活用したいウイルス肝炎の最新情報 抗ウイルス治療中のB型肝炎における発癌リスク

    榎本 大, 河田 則文

    Medical Practice   34 ( 5 )   761 - 766   2017.05( ISSN:0910-1551

  • 【臨床応用を見据えた肝線維化研究の新展開】病態・病理 Cytoglobinと肝星細胞活性化 Reviewed

    榎本 大, 元山 宏行, 河田 則文

    (株)アークメディア 肝・胆・膵   74 ( 1 )   41 - 46   2017.01( ISSN:0389-4991

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  • 【臨床応用を見据えた肝線維化研究の新展開】病態・病理 Cytoglobinと肝星細胞活性化

    榎本 大, 元山 宏行, 河田 則文

    肝胆膵   74 ( 1 )   41 - 46   2017.01( ISSN:0389-4991

  • 直接作用型抗ウイルス薬の時代における慢性C型肝炎の感染に対するインターフェロン-α/β療法(Interferon-α/β for treatment of chronic hepatitis C infection in the era of direct-acting antiviral agents)

    Enomoto Masaru, Tamori Akihiro, Murakami Yoshiki, Kawada Norifumi

    Hepatology Research   44 ( 4 )   371 - 376   2014.04( ISSN:1386-6346

  • Aberrant expression of microRNA according to aging is participating in hepatocarcinogenesis Reviewed

    Murakami Yoshiki, Itami Saori, Toyoda Hidenori, Kumada Takashi, Tanahashi Toshihito, Kawamura Etsushi, Hagihara Atsushi, Uchida Sawako K., Morikawa Hiroyasu, Enomoto Masaru, Tamori Akihiro, Kawada Norifumi, Taguchi Y-H

    HEPATOLOGY   60   881A - 882A   2014( ISSN:0270-9139

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  • Aberrant expression of microRNA according to aging is participating in hepatocarcinogenesis Reviewed

    Murakami Yoshiki, Itami Saori, Toyoda Hidenori, Kumada Takashi, Tanahashi Toshihito, Kawamura Etsushi, Hagihara Atsushi, Uchida Sawako K, Morikawa Hiroyasu, Enomoto Masaru, Tamori Akihiro, Kawada Norifumi, Taguchi Y-H

    HEPATOLOGY   60   881A - 882A   2014( ISSN:0270-9139

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  • 【C型肝炎治療2014:経口抗ウイルス薬時代の到来】DAA時代のインターフェロン DAA時代のインターフェロンα/β製剤の位置付け Reviewed

    榎本 大, 田守 昭博, 村上 善基, 河田 則文

    (株)アークメディア 肝・胆・膵   67 ( 6 )   997 - 1002   2013.12( ISSN:0389-4991

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  • 【C型肝炎治療2014:経口抗ウイルス薬時代の到来】DAA時代のインターフェロン DAA時代のインターフェロンα/β製剤の位置付け

    榎本 大, 田守 昭博, 村上 善基, 河田 則文

    肝胆膵   67 ( 6 )   997 - 1002   2013.12( ISSN:0389-4991

  • 慢性B型肝炎に対するヌクレオシ(チ)ドアナログとインターフェロンの併用療法 同時投与か交替投与か(Combination therapy with a nucleos(t)ide analogue and interferon for chronic hepatitis B: simultaneous or sequential)

    Enomoto Masaru, Tamori Akihiro, Nishiguchi Shuhei, Kawada Norifumi

    Journal of Gastroenterology   48 ( 9 )   999 - 1005   2013.09( ISSN:0944-1174

  • HCV遺伝子型1型の治療ガイドライン 低ウイルス量患者には単剤療法、高ウイルス量患者には3剤併用療法、中等度ウイルス量患者には2剤併用療法か(Treatment guidelines for HCV genotype 1: mono for low, triple for high, and dual for 'middle'?)

    Enomoto Masaru, Tamori Akihiro, Kobayashi Sawako, Iwai Shuji, Morikawa Hiroyasu, Kawada Norifumi

    Journal of Gastroenterology   48 ( 4 )   555 - 556   2013.04( ISSN:0944-1174

  • 抗B型肝炎ウイルス療法 中止すべきか、継続すべきか 問題は解決されたのか(Anti-hepatitis B virus therapy: To stop, or not to stop: Has the question been solved?)

    Kozuka Ritsuzo, Enomoto Masaru, Morikawa Hiroyasu, Tamori Akihiro, Kawada Norifumi

    Hepatology Research   42 ( 9 )   946 - 947   2012.09( ISSN:1386-6346

  • 【B型肝炎の抗ウイルス療法の進歩と耐性】HBe抗原陽性B型慢性肝炎に対するIFN sequential治療中のHBs抗原、HBコア関連抗原の変化と核酸アナログ中止の可能性 Reviewed

    榎本 大, 田守 昭博, 西口 修平, 河田 則文

    (有)科学評論社 消化器内科   54 ( 5 )   627 - 632   2012.05( ISSN:1884-2895

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  • 【B型肝炎の抗ウイルス療法の進歩と耐性】HBe抗原陽性B型慢性肝炎に対するIFN sequential治療中のHBs抗原、HBコア関連抗原の変化と核酸アナログ中止の可能性

    榎本 大, 田守 昭博, 西口 修平, 河田 則文

    消化器内科   54 ( 5 )   627 - 632   2012.05( ISSN:1884-2895

  • B型・C型肝炎の最新情報 ガイドラインから個別化治療へ Reviewed

    榎本 大

    (一社)大阪府内科医会 大阪府内科医会会誌   21 ( 1 )   2 - 8   2012.04( ISSN:1881-669X

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  • B型・C型肝炎の最新情報 ガイドラインから個別化治療へ

    榎本 大

    大阪府内科医会会誌   21 ( 1 )   2 - 8   2012.04( ISSN:1881-669X

  • 【新時代のウイルス性肝炎学 基礎・臨床研究の進歩】B型肝炎 B型肝炎の自然経過 Reviewed

    遠山 まどか, 榎本 大, 田守 昭博, 河田 則文

    (株)日本臨床社 日本臨床   69 ( 増刊4 新時代のウイルス性肝炎学 )   335 - 338   2011.05( ISSN:0047-1852

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  • 【B型慢性肝炎に対する最新の治療】核酸アナログ/IFN sequential治療の有用性とその限界 Reviewed

    榎本 大, 田守 昭博, 西口 修平, 河田 則文

    (一財)日本消化器病学会 日本消化器病学会雑誌   108 ( 2 )   215 - 222   2011.02( ISSN:0446-6586

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    B型慢性肝炎に対する核酸アナログ治療では中止による肝炎の再燃と長期投与による耐性が問題となる。一方、インターフェロン(IFN)の治療効果も限定的である。Serfatyらは、IFNの前にラミブジンを先行投与するいわゆるsequential治療の良好な成績を報告した。その後、多くの施設で追試が行われたが、特にgenotype Cが多数を占める本邦での成績は芳しくない。一方、若年例、急性増悪例、ラミブジン投与中のウイルスの低下が良好な症例では著効も期待できることが明らかになってきた。今後、エンテカビルやPEG-IFNの使用も含め、sequential治療の位置づけについて更なる検討が必要である。(著者抄録)

  • 【B型慢性肝炎に対する最新の治療】核酸アナログ/IFN sequential治療の有用性とその限界

    榎本 大, 田守 昭博, 西口 修平, 河田 則文

    日本消化器病学会雑誌   108 ( 2 )   215 - 222   2011.02( ISSN:0446-6586

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    B型慢性肝炎に対する核酸アナログ治療では中止による肝炎の再燃と長期投与による耐性が問題となる。一方、インターフェロン(IFN)の治療効果も限定的である。Serfatyらは、IFNの前にラミブジンを先行投与するいわゆるsequential治療の良好な成績を報告した。その後、多くの施設で追試が行われたが、特にgenotype Cが多数を占める本邦での成績は芳しくない。一方、若年例、急性増悪例、ラミブジン投与中のウイルスの低下が良好な症例では著効も期待できることが明らかになってきた。今後、エンテカビルやPEG-IFNの使用も含め、sequential治療の位置づけについて更なる検討が必要である。(著者抄録)

  • 【B型肝炎治療の最新戦略】B型慢性肝炎に対する核酸アナログ/IFN sequential治療の有用性 Reviewed

    榎本 大, 田守 昭博, 西口 修平, 河田 則文

    (有)科学評論社 消化器内科   52 ( 1 )   115 - 119   2011.01( ISSN:1884-2895

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  • 【B型肝炎治療の最新戦略】B型慢性肝炎に対する核酸アナログ/IFN sequential治療の有用性

    榎本 大, 田守 昭博, 西口 修平, 河田 則文

    消化器内科   52 ( 1 )   115 - 119   2011.01( ISSN:1884-2895

  • 【内科疾患の診断基準 病型分類・重症度】肝胆膵 自己免疫性肝炎 Reviewed

    小塚 立蔵, 榎本 大, 河田 則文

    (株)南江堂 内科   105 ( 6 )   986 - 991   2010.06( ISSN:0022-1961

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  • 【内科疾患の診断基準 病型分類・重症度】診断メモ 薬物性肝障害 Reviewed

    榎本 大, 河田 則文

    (株)南江堂 内科   105 ( 6 )   1025 - 1025   2010.06( ISSN:0022-1961

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  • 【内科疾患の診断基準 病型分類・重症度】診断メモ 肝腎症候群 Reviewed

    榎本 大, 河田 則文

    (株)南江堂 内科   105 ( 6 )   1028 - 1028   2010.06( ISSN:0022-1961

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  • 【内科疾患の診断基準 病型分類・重症度】肝胆膵 自己免疫性肝炎

    小塚 立蔵, 榎本 大, 河田 則文

    内科   105 ( 6 )   986 - 991   2010.06( ISSN:0022-1961

  • 【内科疾患の診断基準 病型分類・重症度】診断メモ 薬物性肝障害

    榎本 大, 河田 則文

    内科   105 ( 6 )   1025 - 1025   2010.06( ISSN:0022-1961

  • 【内科疾患の診断基準 病型分類・重症度】診断メモ 肝腎症候群

    榎本 大, 河田 則文

    内科   105 ( 6 )   1028 - 1028   2010.06( ISSN:0022-1961

  • ACCUMULATION OF HEPATITIS B VIRUS DNA IN HEPATOCELLULAR CARCINOMA OF PATIENTS WITH SUSTAINED VIROLOGICAL RESPONSE FOR HEPATITIS C VIRUS Reviewed

    Tomori Akihiro, Hoyashi Takehiro, Shinzaki Mayumi, Koboyshi Sawakc, Iwai Shuji, Morikowo Hiroyosu, Enomoto Mosoru, Sokoguchi Hiroki, Shiomi Susumu, Kubo Shoji, Kawada Norifumi

    HEPATOLOGY   48 ( 4 )   694A - 694A   2008.10( ISSN:0270-9139

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  • ACCUMULATION OF HEPATITIS B VIRUS DNA IN HEPATOCELLULAR CARCINOMA OF PATIENTS WITH SUSTAINED VIROLOGICAL RESPONSE FOR HEPATITIS C VIRUS Reviewed

    Tomori Akihiro, Hoyashi Takehiro, Shinzaki Mayumi, Koboyshi Sawakc, Iwai Shuji, Morikowo Hiroyosu, Enomoto Mosoru, Sokoguchi Hiroki, Shiomi Susumu, Kubo Shoji, Kawada Norifumi

    HEPATOLOGY   48 ( 4 )   694A - 694A   2008.10( ISSN:0270-9139

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