Updated on 2023/05/21

写真a

 
MATSUURA Tadashi
 
Organization
Graduate School of Medicine Department of Clinical Medical Science Associate Professor
School of Medicine Department of Medical Science
Title
Associate Professor
Affiliation
Institute of Medicine

Position

  • Graduate School of Medicine Department of Clinical Medical Science 

    Associate Professor  2022.04 - Now

  • School of Medicine Department of Medical Science 

    Associate Professor  2022.04 - Now

Degree

  • M.D. Ph.D. ( Osaka City University )

Research Areas

  • Life Science / Anesthesiology

Research Interests

  • local anestnetics

  • patch clamp

Research Career

  • 局所麻酔薬に関する研究。1, 局所麻酔薬のプロトンチャネルに対する作用。2, 局所麻酔薬中毒:局所麻酔薬の心毒性に対するリピッドレスキューの機序解明

    局所麻酔薬、イオンチャネル 

    2007.12 

Professional Memberships

  • Japanese Society of Anesthesiologist

      Domestic

Committee Memberships (off-campus)

  • general member   Japanese Society of Anesthesiologist  

Awards

  • Dean Award of Medicine 2012

    2013.03  

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    Country:Japan

  • Dean Award of Medicine 2012

    2013.03  

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    Country:Japan

  • The 56th Annual Meeting of the Japanese society of Anesthesiologists Best presentation award

    2009  

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    Country:Japan

  • Osaka City Mayor award

    2009  

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    Country:Japan

  • The 56th Annual Meeting of the Japanese society of Anesthesiologists Best presentation award

    2009  

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    Country:Japan

  • Osaka City Mayor award

    2009  

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    Country:Japan

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Education

  • Osaka City University   Anesthesiology   Doctor's Course   Graduated/Completed

    - 2011

  • National Defense Medical College   Medicine     Graduated/Completed

    - 2000

Papers

  • Inhibition of voltage-gated proton channels by local anaesthetics in GMI-R1 rat microglia

    Tadashi Matsuura, Takashi Mori, Megumi Hasaka, Miyiuki Kuno, Junko Kawawaki, Kiyonobu Nishikawa, Toshio Narahashi, et al

    The Journal of Physiology   590 ( 4 )   827 - 844   2012.02( ISSN:0022-3751

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    Publishing type:Research paper (scientific journal)  

  • Kindler症候群における全身麻酔の経験 Reviewed

    脇 彩也香, 堀 耕太郎, 日野 秀樹, 辻川 翔吾, 松浦 正, 西川 精宣, 森 隆

    麻酔   71 ( 11 )   1231 - 1233   2022.11( ISSN:0021-4892

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    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work   International / domestic magazine:Domestic journal  

    Kindler症候群は,まれな表皮水疱症の一型であり,機械的刺激で容易に水疱を生じ,瘢痕拘縮を繰り返す。気道確保が問題となり,全身麻酔はなるべく避けるべきであるが,皮膚悪性腫瘍切除および植皮術に対し,気管支ファイバースコープを用いた気管挿管による全身麻酔を計画し,大きな合併症なく管理することができた。(著者抄録)

  • Anesthetic Management for Mucopolysaccharidosis Type VII

    FUJII Atsuya, HINO Hideki, FUNAI Yusuke, SUEHIRO Koichi, MATSUURA Tadashi, MORI Takashi

    THE JOURNAL OF JAPAN SOCIETY FOR CLINICAL ANESTHESIA   42 ( 5 )   462 - 466   2022.09( ISSN:02854945

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    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work   International / domestic magazine:Domestic journal  

    <p>Mucopolysaccharidosis(MPS)is a rare genetic disease which is characterized by deformities and other abnormalities of various organs. The management of difficult airways is the most crucial element in anesthetic management. Among several types of MPS, type VII is extremely rare, and there have been only a few case reports regarding general anesthesia management. We describe the case of a 7-year-old boy with MPS type VII whose previous surgery was cancelled due to an airway problem after tracheal intubation at the age of two.</p>

    DOI: 10.2199/jjsca.42.462

  • Lipid emulsion facilitates reversal from volatile anesthetics in a rodent model. Reviewed

    Hori K, Matsuura T, Tsujikawa S, Hino H, Kuno M, Oda Y, Nishikawa K, Mori T

    Clinical toxicology (Philadelphia, Pa.)   60 ( 6 )   716 - 724   2022.06( ISSN:1556-3650

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    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work   International / domestic magazine:International journal  

    DOI: 10.1080/15563650.2021.2020280

    PubMed

  • 心肥大モデルラットではTRPCチャネルの過剰発現が関与してブピバカインによる心毒性が増強する Invited

    日野 秀樹, 松浦 正, 堀 耕太郎, 辻川 翔吾, 森 隆, 西川 精宣

    麻酔   70 ( 増刊 )   S210 - S217   2021.11( ISSN:0021-4892

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    Authorship:Lead author, Last author, Corresponding author   Publishing type:Research paper (scientific journal)   Kind of work:Joint Work   International / domestic magazine:Domestic journal  

    左室肥大の局所麻酔薬感受性亢進に対するtransient receptor potential canonical(TRPC)チャネルの影響について検討した。3週齢の雄性SDラットを用いて左室肥大モデルラット(mTAC)を作成し、ブピバカイン持続静注による血行動態変化の比較、単離左室心筋細胞でのパッチクランプ法によるNa+電流の比較、トランスフェクションHEK-293T細胞でのパッチクランプ法によるNa+電流測定、単離心筋細胞膜上のTRPC3発現の比較を行った。mTACモデルでは有意にブピバカインによる心抑制が増強しており、TRPC3を活性化することでブピバカインによるNa+電流抑制が増強した。また、Nav1.5発現HEK-293T細胞を用いた実験でも、TRPC3が共発現することでNa+電流抑制が増強し、mTACラットでは左室心筋細胞の細胞膜上へのTRPC3タンパク発現が増加していた。左室肥大では局所麻酔薬による心抑制が増強され、TRPC3チャネルを介してイオン型局所麻酔薬が通過することが関連していると考えられた。

  • Left Ventricular Hypertrophy Increases Susceptibility to Bupivacaine-induced Cardiotoxicity through Overexpression of Transient Receptor Potential Canonical Channels in Rats Reviewed

    Hino H.

    Anesthesiology   133 ( 5 )   1077 - 1092   2020.11( ISSN:00033022

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    Authorship:Corresponding author   Publishing type:Research paper (scientific journal)   Kind of work:Joint Work   International / domestic magazine:International journal  

    DOI: 10.1097/ALN.0000000000003554

  • Reply to the editor Reviewed

    Hino Hideki, Matsuura Tadashi

    JOURNAL OF ANESTHESIA   33 ( 6 )   706 - 706   2019.12( ISSN:0913-8668

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00540-019-02687-5

  • Reply to the editor Reviewed

    Hino Hideki, Matsuura Tadashi

    JOURNAL OF ANESTHESIA   33 ( 6 )   706 - 706   2019.12( ISSN:0913-8668

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00540-019-02687-5

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  • Comparison between hemodynamic effects of propofol and thiopental during general anesthesia induction with remifentanil infusion: a double-blind, age-stratified, randomized study(和訳中) Reviewed

    Hino Hideki, Matsuura Tadashi, Kihara Yuki, Tsujikawa Shogo, Mori Takashi, Nishikawa Kiyonobu

    (公社)日本麻酔科学会 Journal of Anesthesia   33 ( 4 )   509 - 515   2019.08( ISSN:0913-8668

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  • Comparison between hemodynamic effects of propofol and thiopental during general anesthesia induction with remifentanil infusion: a double-blind, age-stratified, randomized study Reviewed

    Hino Hideki, Matsuura Tadashi, Kihara Yuki, Tsujikawa Shogo, Mori Takashi, Nishikawa Kiyonobu

    JOURNAL OF ANESTHESIA   33 ( 4 )   509 - 515   2019.08( ISSN:0913-8668

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00540-019-02657-x

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  • Comparison of the venous-arterial CO<sub>2</sub> to arterial-venous O<sub>2</sub> content difference ratio with the venous-arterial CO<sub>2</sub> gradient for the predictability of adverse outcomes after cardiac surgery. Reviewed

    Mukai A, Suehiro K, Kimura A, Funai Y, Matsuura T, Tanaka K, Yamada T, Mori T, Nishikawa K

    Journal of clinical monitoring and computing   2019.02( ISSN:1387-1307

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s10877-019-00286-z

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  • The Sum of Early Diastolic Annulus Velocities in the Mitral and Tricuspid Valve Can Predict Adverse Events After Cardiac Surgery. Reviewed

    Mukai A, Suehiro K, Fujimoto Y, Matsuura T, Tanaka K, Funao T, Yamada T, Mori T, Nishikawa K

    Journal of cardiothoracic and vascular anesthesia   33 ( 1 )   149 - 156   2019.01( ISSN:1053-0770

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    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work   International / domestic magazine:International journal  

    DOI: 10.1053/j.jvca.2018.05.043

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  • In Response. Reviewed

    Tsujikawa S, Matsuura T, Hori K, Mori T, Kuno M, Nishikawa K

    Anesthesia and analgesia   126 ( 6 )   2148   2018.06( ISSN:0003-2999

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1213/ANE.0000000000002884

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  • Superior Efficacy of Lipid Emulsion Infusion Over Serum Alkalinization in Reversing Amitriptyline-Induced Cardiotoxicity in Guinea Pig. Reviewed

    Tsujikawa S, Matsuura T, Hori K, Mori T, Kuno M, Nishikawa K

    Anesthesia and analgesia   126 ( 4 )   1159 - 1169   2018.04( ISSN:0003-2999

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1213/ANE.0000000000002707

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  • Superior Efficacy of Lipid Emulsion Infusion Over Serum Alkalinization in Reversing Amitriptyline-Induced Cardiotoxicity in Guinea Pig. Reviewed

    Tsujikawa S, Matsuura T, Hori K, Mori T, Kuno M, Nishikawa K

    Anesthesia and analgesia   126 ( 4 )   1159 - 1169   2018.04( ISSN:0003-2999

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    DOI: 10.1213/ANE.0000000000002707

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  • In Response. Reviewed

    Tsujikawa S, Matsuura T, Hori K, Mori T, Kuno M, Nishikawa K

    Anesthesia and analgesia   2018.03( ISSN:0003-2999

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1213/ANE.0000000000002884

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  • Neuropathic pain attenuates ischemia reperfusion injury through beta 2-adrenergic pathway Reviewed

    Kawai Shigeaki, Yamada Tokuhiro, Matsuura Tadashi, Funao Tomoharu, Nishikawa Kiyonobu

    LIFE SCIENCES   187   9 - 16   2017.10( ISSN:0024-3205

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.lfs.2017.08.002

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  • Usefulness and growing need for intraoperative transthoracic echocardiography: a case series Reviewed

    Hori Kotaro, Matsuura Tadashi, Mori Takashi, Nishikawa Kiyonobu

    BMC ANESTHESIOLOGY   15   90   2015.06( ISSN:1471-2253

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    DOI: 10.1186/s12871-015-0066-0

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  • Usefulness and growing need for intraoperative transthoracic echocardiography: a case series Reviewed

    Kotaro Hori, Tadashi Matsuura, Takashi Mori, Kiyonobu Nishikawa

    BMC ANESTHESIOLOGY   15   90   2015.06( ISSN:1471-2253

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    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work   International / domestic magazine:International journal  

    Background: Physician-performed transthoracic echocardiography (TTE) is still seldom used during anesthesia. Despite its various advantages, there are only a few reports of intraoperative TTE. We report 3 cases in which intraoperative TTE was successfully used.
    Case presentation: A 75-year-old woman (Case 1) was scheduled for a posterior spinal fusion. When the wound was being closed, systolic blood pressure suddenly dropped to 30 mmHg. TTE revealed hypokinesis in the antero-septal region. Emergent coronary angiography showed 90 % stenosis in left anterior descending artery (Segment 7), and a bare metal stent was implanted. A 71-year-old woman (Case 2) with hypertrophic cardiomyopathy was scheduled for brain tumor operation. During anesthesia induction, the patient developed hemodynamic instability. TTE showed systolic anterior motion of the mitral valve, and appropriate treatment was administered. A 78-year-old woman (Case 3) was scheduled for revision total hip arthroplasty. When the wound was closed, TTE revealed severe hypovolemia despite massive infusion. We insisted on reopening the wound and found additional massive hemorrhage.
    Conclusion: Intraoperative TTE is a potent tool for quick hemodynamic evaluation because it is noninvasive and has sufficient diagnostic capabilities. The successful outcomes of our cases suggest the great usefulness of intraoperative TTE, and more frequent use is to be encouraged.

    DOI: 10.1186/s12871-015-0066-0

    PubMed

  • Improved Performance of the Fourth-Generation FloTrac/Vigileo System for Tracking Cardiac Output Changes Reviewed

    Suehiro Koichi, Tanaka Katsuaki, Mikawa Mika, Uchihara Yuriko, Matsuyama Taiki, Matsuura Tadashi, Funao Tomoharu, Yamada Tokuhiro, Mori Takashi, Nishikawa Kiyonobu

    JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA   29 ( 3 )   656 - 662   2015.06( ISSN:1053-0770

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    DOI: 10.1053/j.jvca.2014.07.022

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  • The ability of the Vigileo-FloTrac system to measure cardiac output and track cardiac output changes during one-lung ventilation Reviewed

    Suehiro Koichi, Tanaka Katsuaki, Yamada Tokuhiro, Matsuura Tadashi, Mori Takashi, Funao Tomoharu, Nishikawa Kiyonobu

    JOURNAL OF CLINICAL MONITORING AND COMPUTING   29 ( 3 )   333 - 339   2015.06( ISSN:1387-1307

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s10877-014-9609-z

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  • The ability of the Vigileo-FloTrac system to measure cardiac output and track cardiac output changes during one-lung ventilation Reviewed

    Koichi Suehiro, Katsuaki Tanaka, Tokuhiro Yamada, Tadashi Matsuura, Takashi Mori, Tomoharu Funao, Kiyonobu Nishikawa

    JOURNAL OF CLINICAL MONITORING AND COMPUTING   29 ( 3 )   333 - 9   2015.06( ISSN:1387-1307

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    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work   International / domestic magazine:International journal  

    This study was aimed at comparing the cardiac output (CO) measured by the Vigileo (TM)-FloTrac (TM) system with that estimated by the thermodilution pulmonary artery catheter (PAC) during one-lung ventilation (OLV) and determining the reliability of this system in tracking phenylephrine-induced CO changes during OLV. Sixteen patients scheduled for descending aorta replacement were enrolled. The study was performed 30 min after starting OLV under stable hemodynamic conditions. We recorded hemodynamic variables, CO measured by PAC thermodilution (ICO), CO measured by Vigileo (TM)-FloTrac (TM) system (Version 3.02, Edwards Lifesciences, Irvine, CA, USA) (APCO), and systemic vascular resistance index (SVRI) before (T0) and after (T1) phenylephrine (100 mu g) administration. We used Bland-Altman analysis to compare ICO and APCO. Polar plot and four-quadrant plot were used to assess the tracking ability of the Vigileo (TM)-FloTrac (TM) system against ICO after administration of phenylephrine. Ninety hemodynamic interventions were performed. Bland-Altman analysis revealed that the mean bias between APCO and ICO was 0.05 L/min and the percentage error, 46.9 %. Four-quadrant plot analysis showed a concordance rate of 24.7 %, while polar plot analysis showed that the concordance rate was 13.3 %; the angular bias, -45.9A degrees; radial limit of agreement, 85.3A degrees. The bias between APCO and ICO was significantly correlated with the SVRI value (p &lt; 0.001, r(2) = 0.822). The reliability of the Vigileo (TM)-FloTrac (TM) system during OLV to estimate CO and track phenylephrine-induced CO changes was not acceptable.

    DOI: 10.1007/s10877-014-9609-z

    PubMed

  • The utility of intra-operative three-dimensional transoesophageal echocardiography for dynamic measurement of stroke volume Reviewed

    Suehiro K., Tanaka K., Yamada T., Matsuura T., Funao T., Mori T., Nishikawa K.

    ANAESTHESIA   70 ( 2 )   150 - 159   2015.02( ISSN:0003-2409

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    DOI: 10.1111/anae.12857

  • The utility of intra-operative three-dimensional transoesophageal echocardiography for dynamic measurement of stroke volume Reviewed

    K. Suehiro, K. Tanaka, T. Yamada, T. Matsuura, T. Funao, T. Mori, K. Nishikawa

    ANAESTHESIA   70 ( 2 )   150 - 9   2015.02( ISSN:0003-2409

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    Measurement of left ventricular stroke volume and cardiac output is very important for managing haemodynamically unstable or critically ill patients. The aims of this study were to compare stroke volume measured by three-dimensional transoesophageal echocardiography with stroke volume measured using a pulmonary artery catheter, and to examine the ability of three-dimensional transoesophageal echocardiography to track stroke volume changes induced by haemodynamic interventions. This study included 40 cardiac surgery patients. Haemodynamic variables were measured before and 2min after haemodynamic interventions, which consisted of phenylephrine 100g or ephedrine 5mg. We used Bland-Altman analysis to assess the agreement between the stroke volume measured by three-dimensional transoesophageal echocardiography and by the pulmonary artery catheter. Polar-plot and 4-quadrant plot analyses were used to assess the trending ability of three-dimensional transoesophageal echocardiography compared with the pulmonary artery catheter. Bias and percentage error were -1.2ml and 20%, respectively. The concordance rate in the 4-quadrant analysis after phenylephrine and ephedrine administration was 75% and 84%, respectively. In the polar-plot analysis, the angular concordance rate was 66% and 73% after phenylephrine and ephedrine administration, respectively. Three-dimensional transoesophageal echocardiography was clinically acceptable for measuring stroke volume; however, it was not sufficiently reliable for tracking stroke volume changes after haemodynamic interventions.

    DOI: 10.1111/anae.12857

    PubMed

  • 全身血管抵抗は心拍出量の測定およびその変化をモニタリングするVigileo-Flo systemの有用性に影響を及ぼす Reviewed

    末廣 浩一, 田中 克明, 舟尾 友晴, 松浦 正, 森 隆, 西川 精宣

    克誠堂出版(株) 麻酔   63 ( 増刊 )   S143 - S152   2014.11( ISSN:0021-4892

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    ビジレオフロートラックシステム(VFS)と肺動脈カテーテル法(PAC)による心拍出量を比較し、末梢血管抵抗との関係を検討した。PACを使用する心臓血管外科症例40例155組を対象とした。低SVRI 44例、正常63例、高SVRI 48例であった。フェニレフリン投与後、APCOは有意に増加したが、ICOは低SVRI、正常SVRIでは有意に変化はみられず、高SVRIで有意に減少した。フェニレフリン投与前・後のPEは、低SVRI 46.3%、41.5%、正常SVRI 26.4%、37.6%、高SVRI 61.4%、75.7%であった。CRは、低SVRI 67.5%、正常SVRI 28.8%、高SVRI 7.7%であった。angular CRが、低SVRI 42.1%、正常SVRI 25.0%、高SVRI 5.3%であった。

  • The Vigileo-FloTrac (TM) System: Arterial Waveform Analysis for Measuring Cardiac Output and Predicting Fluid Responsiveness: A Clinical Review Reviewed

    Suehiro Koichi, Tanaka Katsuaki, Matsuura Tadashi, Funao Tomoharu, Yamada Tokuhiro, Mori Takashi, Nishikawa Kiyonobu

    JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA   28 ( 5 )   1361 - 1374   2014.10( ISSN:1053-0770

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1053/j.jvca.2014.02.020

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  • The Vigileo-FloTracTMsystem: Arterial waveform analysis for measuring cardiac output and predicting fluid responsiveness: A clinical review Reviewed

    Koichi Suehiro, Katsuaki Tanaka, Tadashi Matsuura, Tomoharu Funao, Tokuhiro Yamada, Takashi Mori, Kiyonobu Nishikawa

    Journal of Cardiothoracic and Vascular Anesthesia   28 ( 5 )   1361 - 74   2014.10( ISSN:1053-0770

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    DOI: 10.1053/j.jvca.2014.02.020

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  • Preoperative hydroperoxide concentrations are associated with an increased risk of postoperative complications after cardiac surgery Reviewed

    Suehiro K., Tanaka K., Matsuura T., Funao T., Yamada T., Mori T., Tsuchiya M., Nishikawa K.

    ANAESTHESIA AND INTENSIVE CARE   42 ( 4 )   487 - 494   2014.07( ISSN:0310-057X

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  • Discrepancy Between Superior Vena Cava Oxygen Saturation and Mixed Venous Oxygen Saturation Can Predict Postoperative Complications in Cardiac Surgery Patients Reviewed

    Suehiro Koichi, Tanaka Katsuaki, Matsuura Tadashi, Funao Tomoharu, Yamada Tokuhiro, Mori Takashi, Nishikawa Kiyonobu

    JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA   28 ( 3 )   528 - 533   2014.06( ISSN:1053-0770

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    DOI: 10.1053/j.jvca.2013.03.002

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  • Detection of Left Ventricular Dysfunction Using Early Diastolic Mitral Annular Velocity in Patients Undergoing Mitral Valve Repair for Mitral Regurgitation Reviewed

    Suehiro Koichi, Tanaka Katsuaki, Matsuura Tadashi, Funao Tomoharu, Yamada Tokuhiro, Mori Takashi, Nishikawa Kiyonobu

    JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA   28 ( 1 )   25 - 30   2014.02( ISSN:1053-0770

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    DOI: 10.1053/j.jvca.2013.07.013

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  • The Effect of Lipid Emulsion on Intracellular Bupivacaine as a Mechanism of Lipid Resuscitation: An Electrophysiological Study Using Voltage-Gated Proton Channels Reviewed

    Hori Kotaro, Matsuura Tadashi, Mori Takashi, Kuno Miyuki, Sawada Makoto, Nishikawa Kiyonobu

    ANESTHESIA AND ANALGESIA   117 ( 6 )   1293 - 1301   2013.12( ISSN:0003-2999

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1213/ANE.0000000000000011

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  • The Effect of Lipid Emulsion on Intracellular Bupivacaine as a Mechanism of Lipid Resuscitation: An Electrophysiological Study Using Voltage-Gated Proton Channels Reviewed

    Kotaro Hori, Tadashi Matsuura, Takashi Mori, Miyuki Kuno, Makoto Sawada, Kiyonobu Nishikawa

    ANESTHESIA AND ANALGESIA   117 ( 6 )   1293 - 301   2013.12( ISSN:0003-2999

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    BACKGROUND: Lipid resuscitation has become a standard treatment for local anesthetic (LA) systemic toxicity, but its mechanisms remain to be fully elucidated. Although the partitioning effect is one of the proposed mechanisms, it is difficult to evaluate its impact independently from several other mechanisms or to examine the intracellular concentration of a LA, which is primarily responsible for LA systemic toxicity. We recently reported that LAs as weak bases reduced voltage-gated proton currents by increasing intracellular pH, which could be estimated from the reversal potentials of the channels (V-rev). Using this characteristic, we examined the partitioning effect in detail and showed its impact on lipid resuscitation.
    METHODS: A whole-cell voltage clamp technique was used to record proton channel currents in a rat microglial cell line (GMI-R1). We used Intralipid (R) 20% as lipid emulsion. The effects of lipid emulsion on the intracellular concentrations of LAs were evaluated by measuring the current amplitude and the V-rev. The intracellular concentrations of LAs were calculated by the Henderson-Hasselbalch equation, using estimated intracellular pH. To confirm the importance of partitioning, we separated lipid by centrifugation. Data are means +/- SD unless otherwise stated.
    RESULTS: Bupivacaine (1 mM) decreased proton currents to 43% +/- 10% of the control and shifted the V-rev to positive voltages (from -88.0 +/- 4.1 to -76.0 +/- 5.5 mV, n = 5 each, P = 0.02). An addition of the lipid emulsion recovered the currents to 79% +/- 2% of the control and returned the V-rev toward the control value (to -86.0 +/- 7.1 mV, n = 5, P = 0.03). Both recoveries of the current and V-rev in the centrifuged aqueous extract were almost the same as in the 4% lipid solution (-85.6 +/- 4.9 mV, n = 5, P = 0.9, 95% confidence interval for difference = -9.3 to 8.6). When 1 mM bupivacaine was applied extracellularly, the intracellular concentration of the charged form of bupivacaine was estimated to reach about 18.1 +/- 3.9 mM but decreased to 5.4 +/- 1.8 mM by the 4% lipid solution.
    CONCLUSIONS: Here we quantitatively evaluated for the first time the partitioning effect of lipid emulsion therapy on the intracellular concentration of bupivacaine in real-time settings by analyzing behaviors of voltage-gated proton channels. Our results suggested that lipid emulsion markedly reduced the intracellular concentration of bupivacaine, which was mostly due to the partitioning effect. This could contribute to our understanding of the mechanisms underlying lipid resuscitation, especially the importance of the partitioning effect.

    DOI: 10.1213/ANE.0000000000000011

    PubMed

  • Systemic vascular resistance has an impact on the reliability of the Vigileo-FloTrac system in measuring cardiac output and tracking cardiac output changes Reviewed

    Suehiro K., Tanaka K., Funao T., Matsuura T., Mori T., Nishikawa K.

    BRITISH JOURNAL OF ANAESTHESIA   111 ( 2 )   170 - 177   2013.08( ISSN:0007-0912

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    DOI: 10.1093/bja/aet022

  • Systemic vascular resistance has an impact on the reliability of the Vigileo-FloTrac system in measuring cardiac output and tracking cardiac output changes Reviewed

    K. Suehiro, K. Tanaka, T. Funao, T. Matsuura, T. Mori, K. Nishikawa

    British Journal of Anaesthesia   111 ( 2 )   170 - 7   2013.08( ISSN:0007-0912

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    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work   International / domestic magazine:International journal  

    BackgroundThe aim of this study was to examine the ability of the Vigileo-FloTrac system to measure cardiac output (CO) and track changes in CO induced by increased vasomotor tone, under different states of systemic vascular resistance (SVR).MethodsForty patients undergoing cardiac surgery were enrolled. Haemodynamic variables including CO measured by the Vigileo-FloTrac system (version 3.02) (APCO), CO measured by a pulmonary artery catheter (ICO), and SVR index (SVRI) were recorded before (T1) and 2 min after (T2) phenylephrine administration (100 μg). Bland and Altman analysis was used to compare ICO and APCO at T1. We used four-quadrant plots and polar plots to compare the trending abilities between ICO and APCO. Patients were divided into three groups according to the SVRI value at T1, with low (&lt
    1200 dyn cm -5 m2), normal (1200-2500 dyn cm-5 m 2), and high (&gt
    2500 dyn cm-5 m2) SVRI states.ResultsA total of 155 paired data were collected. The adjusted percentage error was 46.3%, 26.4%, and 61.4%, and the concordance rate between ΔICO and ΔAPCO was 67.5%, 28.8%, and 7.7% in the low, normal, and high SVRI state, respectively. The polar plot analysis showed that the mean angular bias was -22.3°, -46.0°, and -3.51°, and the radial limits of agreement were 70°, 85°, and 87°, in the low, normal, and high SVRI state, respectively.ConclusionsThese results indicate that the reliability of the Vigileo-FloTrac system to measure CO and track changes in CO induced by phenylephrine administration was not clinically acceptable. © The Author [2013]. Published by Oxford University Press on behalf of the British Journal of Anaesthesia. All rights reserved.

    DOI: 10.1093/bja/aet022

    PubMed

  • 胸部大動脈血管内修復術後の遅発性対麻痺患者の治療成功(Successful Treatment of a Patient with Delayed onset Paraplegia after Thoracic Endovascular Aortic Repair) Reviewed

    Nakamura Taketo, Yamada Tokuhiro, Matsuura Tadashi, Tanaka Katsuaki, Funao Tomoharu, Nishikawa Kiyonobu

    日本循環制御医学会 循環制御   33 ( 2 )   112 - 114   2012.08( ISSN:0389-1844

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    症例は60歳男性で、45歳時に下行大動脈のグラフト置換術を施行されていた。グラフト近傍の嚢状動脈瘤が2年間で徐々に拡大したため、左鎖骨動脈下の遠位大動脈弓動脈瘤に対し全身麻酔下で血管内修復術を行った。手術は5時間46分で終了し、神経学的欠損の兆候は全くみられなかった。しかし、集中治療室入室後3時間目に突然麻痺がみられ、筋力が著明に低下し、右はL1以下、左はL2以下の感覚が低下した。平均動脈圧は術中80mmHg以上、術後90mmHg以上に維持していたが、ドーパミンにより120mmHg以上にしても麻痺は改善しなかった。腰部脳脊髄液ドレナージを速やかに行ったところ、筋力が改善し、触感が正常になったが、右L2以下の温度感覚は消失していた。術後7日目の血管造影では、左鎖骨下動脈と大前根髄質動脈のステントによる閉塞は認められなかった。

  • Effects of general anesthetics on P2X(4) receptors in a mouse microglial cell line Reviewed

    Hasaka Megumi, Mori Takashi, Matsuura Tadashi, Narahashi Toshio, Kuno Miyuki, Asada Akira, Nishikawa Kiyonobu

    NEUROREPORT   23 ( 10 )   601 - 605   2012.07( ISSN:0959-4965

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1097/WNR.0b013e32835509db

    PubMed

  • Inhibition of voltage-gated proton channels by local anaesthetics in GMI-R1 rat microglia. Reviewed

    Matsuura T, Mori T, Hasaka M, Kuno M, Kawawaki J, Nishikawa K, Narahashi T, Sawada M, Asada A

    The Journal of physiology   590 ( 4 )   827 - 44   2012.02( ISSN:0022-3751

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    Authorship:Lead author   Publishing type:Research paper (scientific journal)   Kind of work:Joint Work   International / domestic magazine:International journal  

    DOI: 10.1113/jphysiol.2011.218149

    PubMed

  • Inhibition of voltage-gated proton channels by local anaesthetics in GMI-R1 rat microglia Reviewed

    Matsuura Tadashi, Mori Takashi, Hasaka Megumi, Kuno Miyuki, Kawawaki Junko, Nishikawa Kiyonobu, Narahashi Toshio, Sawada Makoto, Asada Akira

    JOURNAL OF PHYSIOLOGY-LONDON   590 ( 4 )   827 - 844   2012.02( ISSN:0022-3751

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1113/jphysiol.2011.218149

    PubMed

  • Successful Treatment of a Patient with Delayed-Onset Paraplegia after Thoracic Endovascular Aortic Repair Reviewed

    Nakamura Taketo, Yamada Tokuhiro, Matsuura Tadashi, Tanaka Katsuaki, Funao Tomoharu, Nishikawa Kiyonobu

    Japan Society of Circulation Control in Medicine 循環制御   33 ( 2 )   112 - 114   2012( ISSN:0389-1844

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    A 60-year old man developed paraplegia three hours after thoracic endovascular aortic repair under general anesthesia for distal aortic arch aneurysm. This delayed-onset paraplegia was suspected to be due to a steal effect on the spinal small end arteries. The symptom was successfully alleviated by rapid lumbar cerebrospinal fluid drainage.

    DOI: 10.11312/ccm.33.112

    CiNii Article

  • [Anesthesia for three patients with Hunter syndrome]. Reviewed

    Kodani Y, Matsuura T, Mori T, Nishikawa K, Asada A

    Masui. The Japanese journal of anesthesiology   60 ( 7 )   846 - 9   2011.07( ISSN:0021-4892

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    PubMed

  • 症例検討 術前評価と麻酔の説明:患者のよくある質問にどう答えますか? 輸血を拒否する患者:患者・家族との合意が重要,自己血輸血は心強い味方 Invited

    松浦 正, 長谷 一郎, 浅田 章

    LiSA   17 ( 7 )   688 - 692   2010.07( ISSN:13408836

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    Authorship:Lead author, Last author, Corresponding author   Publishing type:Research paper (conference, symposium, etc.)   Kind of work:Joint Work   International / domestic magazine:Domestic journal  

    DOI: 10.11477/mf.3101100978

  • 輸血を拒否する患者:患者・家族との合意が重要、自己血輸血は心強い味方

    松浦正, 長谷一郎, 浅田章

    メディカル・サイエンス・インターナショナル   17 ( 7 )   688 - 692   2010.07( ISSN:1340-8836

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    Publishing type:Research paper (scientific journal)  

  • Gestation-Related Reduction in Lumbar Cerebrospinal Fluid Volume and Dural Sac Surface Area Reviewed

    Onuki Eriko, Higuchi Hideyuki, Takagi Shunichi, Nishijima Kaoru, Fujita Nobuko, Matsuura Tadashi, Ozaki Makoto

    ANESTHESIA AND ANALGESIA   110 ( 1 )   148 - 153   2010.01( ISSN:0003-2999

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1213/ANE.0b013e3181c04faf

    PubMed

  • Gestation-Related Reduction in Lumbar Cerebrospinal Fluid Volume and Dural Sac Surface Area Reviewed

    Eriko Onuki, Hideyuki Higuchi, Shunichi Takagi, Kaoru Nishijima, Nobuko Fujita, Tadashi Matsuura, Makoto Ozaki

    ANESTHESIA AND ANALGESIA   110 ( 1 )   148 - 153   2010.01( ISSN:0003-2999

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    BACKGROUND: Facilitation of the spread of neuraxial anesthesia in pregnant women may be attributable in part to compression of the dural sac by the engorged epidural venous plexus. In this study, we used magnetic resonance imaging to examine pregnancy-induced changes in the lumbosacral cerebrospinal fluid (CSF) volume and dural sac surface area.
    METHODS: Magnetic resonance images of 18 healthy women (mean age 29 yr, mean height 158 cm, and mean weight 58 kg) were obtained to measure lumbosacral CSF volume and dural sac surface area in the nonpregnant and pregnant states (median 36 wk gestation [31-39]) and the paired images were compared.
    RESULTS: The mean lumbosacral CSF volume and dural sac surface area in the nonpregnant state were 39.6 +/- 5.8 mL and 11.0 +/- 0.8 cm(2), respectively. Pregnancy was associated with compression of the dural sac, resulting in a significantly reduced mean CSF volume (33.2 +/- 6.2 mL) and dural sac surface area (9.9 +/- 1.0 cm(2)) in all subjects (P &lt; 0.001). The mean change in CSF volume and dural sac surface area was 16.7% +/- 0.8%) and 10.0% +/- 0.5%, respectively. Gestational week (between 31 and 39 wk) correlated significantly with the reduction in CSF volume (rho = 0.74, P &lt; 0.001) and dural sac surface area (rho = 0.66, P &lt; 0.01).
    CONCLUSIONS: These findings indicate an association between gestational week (Weeks 31-39) and a reduction in both CSF volume and dural sac surface area. These reductions may, at least in part, explain the facilitation of the spread of intrathecal anesthesia in pregnant women. (Anesth Analg 2010;110:148-53)

    DOI: 10.1213/ANE.0b013e3181c04faf

  • Advance of age decreases the minimum alveolar concentrations of isoflurane and sevoflurane for maintaining bispectral index below 50

    Tadashi Matsuura, Yutaka Oda, Katsuaki Tanaka, Takashi Mori, Kiyonobu Nishikawa, Akira Asada

    British Journal of Anaesthesia   102 ( 3 )   331 - 335   2009.03( ISSN:0007-0912

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  • Advance of age decreases the minimum alveolar concentrations of isoflurane and sevoflurane for maintaining bispectral index below 50 Reviewed

    Matsuura T., Oda Y., Tanaka K., Mori T., Nishikawa K., Asada A.

    BRITISH JOURNAL OF ANAESTHESIA   102 ( 3 )   331 - 335   2009.03( ISSN:0007-0912

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/bja/aen382

  • LIDOCAINE INHIBITS VOLTAGE-GATED PROTON CHANNELS IN RAT MICROGLIA Reviewed

    Matsuura Tadashi, Mori Takashi, Kuno Miyuki, Hasaka Megumi, Sawada Makoto, Nishikawa Kiyonobu, Asada Akira

    JOURNAL OF PHYSIOLOGICAL SCIENCES   59   198 - 198   2009( ISSN:1880-6546

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  • Differential electroencephalographic response to tracheal intubation between young and elderly during isoflurane- and sevoflurane-nitrous oxide anaesthesia Reviewed

    Matsuura T., Oda Y., Ikeshita K., Nishikawa K., Ito K., Asada A.

    BRITISH JOURNAL OF ANAESTHESIA   99 ( 6 )   858 - 863   2007.12( ISSN:0007-0912

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/bja/aem300

  • The effect of dexmedetomidine on electrocorticography in in patients with temporal lobe epilepsy under sevoflurane anesthesia Reviewed

    Oda Yutaka, Toriyama Sumiko, Tanaka Katsuaki, Matsuura Tadashi, Hamaoka Naoya, Morino Michiharu, Asada Akira

    ANESTHESIA AND ANALGESIA   105 ( 5 )   1272 - 1277   2007.11( ISSN:0003-2999

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1213/01.ane.0000281075.77316.98

    PubMed

  • Differential electroencephalographic response to tracheal intubation between young and elderly during isoflurane- and sevoflurane-nitrous oxide anaesthesia

    Tadashi Matsuura, Yutaka Oda, Kazutoshi Ikeshita, Kiyonobu Nishikawa, Kazuya Ito, Akira Asada

    British Journal of Anaesthesia   99 ( 6 )   858 - 863   2007.06( ISSN:0007-0912

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  • Nitrous oxide induces paradoxical electroencephalographic changes after tracheal intubation during isoflurane and sevoflurane anesthesia Reviewed

    Oda Y, Tanaka K, Matsuura T, Hase I, Nishikawa K, Asada A

    ANESTHESIA AND ANALGESIA   102 ( 4 )   1094 - 1102   2006.04( ISSN:0003-2999

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1213/01.ane.0000198509.55543.d6

    PubMed

  • Nitrous oxide induces paradoxical electroencephalographic changes after tracheal intubation during isoflurane and sevoflurane anesthesia Reviewed

    Y Oda, K Tanaka, T Matsuura, Hase, I, K Nishikawa, A Asada

    ANESTHESIA AND ANALGESIA   102 ( 4 )   1094 - 102   2006.04( ISSN:0003-2999

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    In this randomized, double-blind, controlled study, we tested the hypothesis that nitrous oxide (N2O) affects bispectral index (BIS) and 95% spectral edge frequency (SEF95) in response to tracheal intubation during anesthesia with isoflurane and sevoflurane. In protocol 1, we randomly allocated 90 ASA physical status I patients to 6 groups (n = 15 each). Anesthesia was induced with isoflurane or sevoflurane with 0%, 33%, or 66% N2O. The concentration of isoflurane and sevoflurane was gradually increased and end-tidal concentrations were maintained at 1.1% and 1.7%, respectively. Tracheal intubation was performed 12 min after induction of anesthesia. BIS was significantly increased 1 min after tracheal intubation compared before laryngoscopy in patients receiving only isoflurane or sevoflurane (P = 0.001 and 0.007, respectively). In patients receiving 66% N2O-isoflurane or 66% N2O-sevoflurane, both BIS and SEF95 were significantly decreased after tracheal intubation and significantly lower than in those patients receiving only isoflurane or sevoflurane, respectively (P &lt; 0.01 for both). In protocol 2, 3 mu g/kg of IV fentanyl completely abolished the decrease of BIS and SEF95 after tracheal intubation during anesthesia with 66% N2O-isoflurane and 66% N2O-sevoflurane (n = 10). We conclude that 66% N2O induced a paradoxical decrease of BIS in response to tracheal intubation during anesthesia with isoflurane and sevoflurane.

    DOI: 10.1213/01.ane.0000198509.55543.d6

    PubMed

  • Anesthetic Management for Caesarean Section in a Patient with Aortic Regurgitation

    Tadashi Matsuura, Tetsuya Takahashi, Marimo Kira, Isao Fukuda, Yoshitaka Uchihashi, Fujio Karasawa, et al.

    The Journal of The Saitama Medical Society   37 ( 5 )   559 - 561   2003.01( ISSN:0389-0899

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  • Repeated Coronary Artery Spasm under general nesthesia

    Tadashi Matsuura, Youko Matsuo, Maiko Satomoto, Yushi Adachi, Hideyuki Higuchi, Tetsuo Satoh

    Masui   51 ( 3 )   283 - 285   2002.03( ISSN:0021-4892

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Books and Other Publications

  • 局所麻酔薬の中枢神経系に対する作用と胎盤通過性(レボブピバカインの基礎と臨床)

    松浦正, 森隆, 浅田章( Role: Joint author)

    克誠堂  2010  ( ISBN:9784771903708

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    Book type:Scholarly book

MISC

Presentations

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Grant-in-Aid for Scientific Research

  • Cardiac hypertrophy associated changes in the effects of local anesthetics on myocardium

    Grant-in-Aid for Early-Career Scientists  2018.04

  • 三環系抗うつ薬中毒に対する脂肪乳剤の有効性ーアルカリ化療法との比較検討

    Grant-in-Aid for Scientific Research(C)  2015.04

  • 局所麻酔薬の心毒性に対するリピッドレスキューの機序解明

    Grant-in-Aid for Young Scientists(B)  2012.04

Charge of on-campus class subject

  • 術前評価

    2018     Undergraduate

  • 術前評価

    2017     Undergraduate

  • 術前評価

    2016     Undergraduate

  • 術前評価

    2015     Undergraduate

  • 術前評価

    2014     Undergraduate

  • 術前評価

    2013     Undergraduate

  • 術前評価

    2012     Undergraduate

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Charge of off-campus class subject

  • 全身麻酔と局所麻酔

Other

  • Job Career

    2011

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    Osaka City University