Updated on 2022/07/13

写真a

 
SHIBA Masatsugu
 
Organization
Graduate School of Medicine Department of Clinical Medical Science Associate Professor
School of Medicine Department of Medical Science
Title
Associate Professor
Affiliation
Institute of Medicine

Position

  • Graduate School of Medicine Department of Clinical Medical Science 

    Associate Professor  2022.04 - Now

  • School of Medicine Department of Medical Science 

    Associate Professor  2022.04 - Now

Degree

  • 医学博士 ( Osaka City University )

Research Areas

  • Life Science / Gastroenterology  / Gastroenterology

Research Career

  • 上部・下部消化管内視鏡に関連する検査・治療の疫学・統計解析

    消化器内視鏡、臨床統計 

    1900.04 

Professional Memberships

  • THE JAPAN SOCIETY OF COLOPROCTOLOBY

      Domestic

Papers

  • Endoscopic Submucosal Dissection for Esophageal Cancer Close to the Previous ESD Scar Reviewed

    Nagami Yasuaki, Ominami Masaki, Fukunaga Shusei, Sakai Taishi, Otani Koji, Hosomi Shuhei, Tanaka Fumio, Taira Koichi, Yamagami Hirokazu, Tanigawa Tetsuya, Shiba Masatsugu, Watanabe Toshio, Fujiwara Yasuhiro

    DIGESTION   101 ( 1 )   89 - 89   2020.01( ISSN:0012-2823

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  • Positive correlation between pancreatic volume and post-endoscopic retrograde cholangiopancreatography pancreatitis Reviewed

    Maruyama Hirotsugu, Shiba Masatsugu, Ishikawa-Kakiya Yuki, Kato Kunihiro, Ominami Masaki, Fukunaga Shusei, Otani Koji, Hosomi Shuhei, Tanaka Fumio, Kamata Noriko, Taira Koichi, Nagami Yasuaki, Yamagami Hirokazu, Tanigawa Tetsuya, Watanabe Toshio, Yamamoto Akira, Kabata Daijiro, Shintani Ayumi, Fujiwara Yasuhiro

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   2019.10( ISSN:0815-9319

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/jgh.14878

    PubMed

  • ORBIT SCORE PREDICTS MAJOR BLEEDING AFTER COLORECTAL POLYPECTOMY IN PATIENTS RECEIVING ORAL ANTICOAGULATION THERAPY Reviewed

    Fukunaga Shusei, Nagami Yasuaki, Ohira Mizuki, Sakai Taishi, Ominami Masaki, Maruyama Hirotsugu, Otani Koji, Hosomi Shuhei, Tanaka Fumio, Taira Koichi, Kamata Noriko, Yamagami Hirokazu, Tanigawa Tetsuya, Shiba Masatsugu, Watanabe Toshio, Fujiwara Yasuhiro

    GASTROINTESTINAL ENDOSCOPY   89 ( 6 )   AB381 - AB381   2019.06( ISSN:0016-5107

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  • RISK FACTORS FOR ADVERSE EVENTS OF ENDOSCOPIC SUBMUCOSAL DISSECTION FOR SUPERFICIAL PHARYNGEAL CANCER USING INVERSE PROBABILITY OF TREATMENT WEIGHTING Reviewed

    Ominami Masaki, Nagami Yasuaki, Hirano Shinji, Kakiya Yuki, Hayashi Kappei, Kinoshita Yosuke, Tanoue Koujiro, Yamamura Masafumi, Sakai Taishi, Maruyama Hirotsugu, Fukunaga Shusei, Otani Koji, Hosomi Shuhei, Tanaka Fumio, Kamata Noriko, Taira Koichi, Yamagami Hirokazu, Tanigawa Tetsuya, Shiba Masatsugu, Watanabe Toshio, Fujiwara Yasuhiro

    GASTROINTESTINAL ENDOSCOPY   89 ( 6 )   AB447 - AB447   2019.06( ISSN:0016-5107

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  • SAFETY OF EMR USED A BIPOLAR SNARE FOR SUPERFICIAL NON-AMPULLARY DUODENAL EPITHELIAL TUMOR AND PREDICTIVE FACTOR OF PIECEMEAL RESECTION Reviewed

    Yamamura Masafumi, Nagami Yasuaki, Hirano Shinji, Kakiya Yuki, Kinoshita Yosuke, Tanoue Koujiro, Hayashi Kappei, Sakai Taishi, Maruyama Hirotsugu, Ominami Masaki, Fukunaga Shusei, Otani Koji, Hosomi Shuhei, Tanaka Fumio, Taira Koichi, Kamata Noriko, Yamagami Hirokazu, Tanigawa Tetsuya, Shiba Masatsugu, Watanabe Toshio, Fujiwara Yasuhiro

    GASTROINTESTINAL ENDOSCOPY   89 ( 6 )   AB356 - AB356   2019.06( ISSN:0016-5107

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  • MULTIPLE LUGOL-VOIDING LESIONS INCREASE THE RISK FOR METACHRONOUS RECURRENCE AFTER ENDOSCOPIC SUBMUCOSAL DISSECTION OF SUPERFICIAL ESOPHAGEAL SQUAMOUS CELL CARCINOMA Reviewed

    Hirano Shinji, Nagami Yasuaki, Kakiya Yuki, Kinoshita Yosuke, Tanoue Koujiro, Hayashi Kappei, Yamamura Masafumi, Sakai Taishi, Maruyama Hirotsugu, Ominami Masaki, Fukunaga Shusei, Otani Koji, Hosomi Shuhei, Tanaka Fumio, Kamata Noriko, Taira Koichi, Yamagami Hirokazu, Tanigawa Tetsuya, Shiba Masatsugu, Watanabe Toshio, Fujiwara Yasuhiro

    GASTROINTESTINAL ENDOSCOPY   89 ( 6 )   AB206 - AB206   2019.06( ISSN:0016-5107

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  • 重症併存症がみられる患者の早期胃癌に対する内視鏡的粘膜下層剥離術の晩期成績 傾向スコアを用いた比較解析(Long-term outcome of endoscopic submucosal dissection for early gastric cancer in patients with severe comorbidities: a comparative propensity score analysis) Reviewed

    Tanoue Kojiro, Fukunaga Shusei, Nagami Yasuaki, Sakai Taishi, Maruyama Hirotsugu, Ominami Masaki, Otani Koji, Hosomi Shuhei, Tanaka Fumio, Taira Koichi, Kamata Noriko, Yamagami Hirokazu, Tanigawa Tetsuya, Shiba Masatsugu, Watanabe Toshio, Fujiwara Yasuhiro

    シュプリンガー・ジャパン(株) Gastric Cancer   22 ( 3 )   558 - 566   2019.05( ISSN:1436-3291

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    早期胃癌の患者に対し内視鏡的粘膜下層剥離術(ESD)を施行した場合の晩期成績を重症併存症の有無で比較する後ろ向きコホート研究を施行した。早期胃癌に罹患し、当院にて2004年2月〜2013年6月にESDを施行され、2016年7月まで経過観察が続けられた患者488名を解析対象とした。そのうち、米国麻酔科学会術前全身状態分類(ASA-PS)にてクラス1または2と分類された患者は375名(対照群)、3と分類され重症併存症を有すると定義された患者は113名(重症併存症群)であった。傾向スコア分析にて比較した結果、重症併存症群の5年全生存率は79.1%であり、対照群での87.7%よりも有意に低かった。Cox比例ハザード回帰分析およびinverse probability of treatment weighting法による分析を施行した結果、どちらの分析方法を用いた場合でも重症併存症群に属することは死亡に関し有意な危険因子となることが示された。有害事象については、傾向スコアマッチングを行った後の両群間において有意差は認められなかった。重症の併存症を有する早期胃癌患者では、重症併存症がみられない患者に比べESDの長期予後が悪化することが示された。

  • Long-term outcome of endoscopic submucosal dissection for early gastric cancer in patients with severe comorbidities: a comparative propensity score analysis Reviewed

    Tanoue Kojiro, Fukunaga Shusei, Nagami Yasuaki, Sakai Taishi, Maruyama Hirotsugu, Ominami Masaki, Otani Koji, Hosomi Shuhei, Tanaka Fumio, Taira Koichi, Kamata Noriko, Yamagami Hirokazu, Tanigawa Tetsuya, Shiba Masatsugu, Watanabe Toshio, Fujiwara Yasuhiro

    GASTRIC CANCER   22 ( 3 )   558 - 566   2019.05( ISSN:1436-3291

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s10120-018-0889-8

    PubMed

  • Impact of preoperative biopsy sampling on severe submucosal fibrosis on endoscopic submucosal dissection for colorectal laterally spreading tumors: a propensity score analysis Reviewed

    Fukunaga Shusei, Nagami Yasuaki, Shiba Masatsugu, Sakai Taishi, Maruyama Hirotsugu, Ominami Masaki, Otani Koji, Hosomi Shuhei, Tanaka Fumio, Taira Koichi, Tanigawa Tetsuya, Yamagami Hirokazu, Watanabe Toshio, Fujiwara Yasuhiro

    GASTROINTESTINAL ENDOSCOPY   89 ( 3 )   470 - 478   2019.03( ISSN:0016-5107

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.gie.2018.08.051

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  • Involvement of gliadin, a component of wheat gluten, in increased intestinal permeability leading to non-steroidal anti-inflammatory drug-induced small-intestinal damage Reviewed

    Shimada Sunao, Tanigawa Tetsuya, Watanabe Toshio, Nakata Akinobu, Sugimura Naoki, Itani Shigehiro, Higashimori Akira, Nadatani Yuji, Otani Koji, Taira Koichi, Hosomi Shuhei, Nagami Yasuaki, Tanaka Fumio, Kamata Noriko, Yamagami Hirokazu, Shiba Masatsugu, Fujiwara Yasuhiro

    PLOS ONE   14 ( 2 )   e0211436   2019.02( ISSN:1932-6203

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    DOI: 10.1371/journal.pone.0211436

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  • Colorectal polyps located across a fold are difficult to resect completely using endoscopic mucosal resection: A propensity score analysis Reviewed

    Minamino Hiroaki, Nagami Yasuaki, Shiba Masatsugu, Hayashi Kappei, Sakai Taishi, Ominami Masaki, Fukunaga Shusei, Hayakawa Tsuyoshi, Aomatsu Kazuki, Sugimori Satoshi, Tanigawa Tetsuya, Yamagami Hirokazu, Watanabe Toshio, Fujiwara Yasuhiro

    UNITED EUROPEAN GASTROENTEROLOGY JOURNAL   6 ( 10 )   1547 - 1555   2018.12( ISSN:2050-6406

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1177/2050640618797854

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  • Heparin-bridging therapy is associated with post-colorectal polypectomy bleeding in patients whose oral anticoagulation therapy is interrupted Reviewed

    Sakai Taishi, Nagami Yasuaki, Shiba Masatsugu, Hayashi Kappei, Kinoshita Yosuke, Maruyama Hirotsugu, Kato Kunihiro, Minamino Hiroaki, Ominami Masaki, Fukunaga Shusei, Otani Koji, Hosomi Shuhei, Tanaka Fumio, Taira Koichi, Kamata Noriko, Yamagami Hirokazu, Tanigawa Tetsuya, Watanabe Toshio, Fujiwara Yasuhiro

    SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY   53 ( 10-11 )   1304 - 1310   2018.11( ISSN:0036-5521

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1080/00365521.2018.1503325

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  • Usefulness of small bowel reexamination in obscure gastrointestinal bleeding patients with negative capsule endoscopy findings: Comparison of repeat capsule endoscopy and double-balloon enteroscopy Reviewed

    Otani Koji, Watanabe Toshio, Shimada Sunao, Nadatani Yuji, Hosomi Shuhei, Nagami Yasuaki, Tanaka Fumio, Kamata Noriko, Taira Koichi, Yamagami Hirokazu, Tanigawa Tetsuya, Shiba Masatsugu, Fujiwara Yasuhiro

    UNITED EUROPEAN GASTROENTEROLOGY JOURNAL   6 ( 6 )   879 - 887   2018.07( ISSN:2050-6406

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1177/2050640618767600

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  • SUCCESSFUL ERADICATION OF HELICOBACTER PYLORI REDUCES THE DEVELOPMENT OF METACHRONOUS GASTRIC CANCER AFTER ENDOSCOPIC SUBMUCOSAL DISSECTION FOR EARLY GASTRIC CANCER: A PROPENSITY MATCHING ANALYSIS Reviewed

    Nakata Rieko, Nagami Yasuaki, Hashimoto Atsushi, Sakai Taishi, Ominami Masaki, Fukunaga Shusei, Otani Koji, Hosomi Shuhei, Tanaka Fumio, Ohira Mizuki, Kamata Noriko, Taira Koichi, Yamagami Hirokazu, Tanigawa Tetsuya, Shiba Masatsugu, Watanabe Toshio, Fujiwara Yasuhiro

    GASTROINTESTINAL ENDOSCOPY   87 ( 6 )   AB52 - AB53   2018.06( ISSN:0016-5107

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  • Combined Infection of Human Herpes Viruses: A Risk Factor for Subsequent Colectomy in Ulcerative Colitis Reviewed

    Hosomi Shuhei, Watanabe Kenji, Nishida Yu, Yamagami Hirokazu, Yukawa Tomomi, Otani Koji, Nagami Yasuaki, Tanaka Fumio, Taira Koichi, Kamata Noriko, Tanigawa Tetsuya, Shiba Masatsugu, Watanabe Toshio, Nagahara Hisashi, Maeda Kiyoshi, Fujiwara Yasuhiro

    INFLAMMATORY BOWEL DISEASES   24 ( 6 )   1307 - 1315   2018.06( ISSN:1078-0998

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/ibd/izy005

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  • ADVERSE EVENTS OF ENDOSCOPIC BALLOON DILATATION FOR ESOPHAGEAL STRICTURE CAUSED BY ENDOSCOPIC SUBMUCOSAL DISSECTION Reviewed

    Nakamura Yoshihiro, Nagami Yasuaki, Yamamura Masafumi, Hayashi Kappei, Kinoshita Yosuke, Tanoue Koujiro, Sakai Taishi, Maruyama Hirotsugu, Kato Kunihiro, Ominami Masaki, Fukunaga Shusei, Sugimori Satoshi, Otani Koji, Hosomi Shuhei, Tanaka Fumio, Taira Koichi, Kamata Noriko, Yamagami Hirokazu, Tanigawa Tetsuya, Shiba Masatsugu, Watanabe Toshio, Fujiwara Yasuhiro

    GASTROINTESTINAL ENDOSCOPY   87 ( 6 )   AB88 - AB89   2018.06( ISSN:0016-5107

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  • CAN THE ORBIT SCORE PREDICT DELAYED BLEEDING AFTER COLORECTAL ENDOSCOPIC SUBMUCOSAL DISSECTION IN PATIENTS RECEIVING ORAL ANTICOAGULATION THERAPY? Reviewed

    Fukunaga Shusei, Nagami Yasuaki, Sakai Taishi, Ominami Masaki, Sugimori Satoshi, Otani Koji, Hosomi Shuhei, Tanaka Fumio, Taira Koichi, Kamata Noriko, Yamagami Hirokazu, Tanigawa Tetsuya, Shiba Masatsugu, Watanabe Toshio, Fujiwara Yasuhiro

    GASTROINTESTINAL ENDOSCOPY   87 ( 6 )   AB399 - AB399   2018.06( ISSN:0016-5107

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  • 食道アカラシアに合併した多発表在型食道癌に対しESDを施行した1例 Reviewed

    丸山 紘嗣, 富永 和作, 坂井 大志, 大南 雅揮, 永見 康明, 杉森 聖司, 斯波 将次, 渡辺 俊雄, 藤原 靖弘, 荒川 哲男

    (一社)日本消化器内視鏡学会 Gastroenterological Endoscopy   60 ( 5 )   1076 - 1082   2018.05( ISSN:0387-1207

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    症例は55歳男性。18年前より嚥下困難を自覚していた。右胸痛を主訴に近医を受診し、当院に紹介となった。食道アカラシア(Flask type)及び多発表在型食道癌(胸部上部食道1病変、胸部中部食道5病変)と診断した。多発表在型食道癌に対して内視鏡的粘膜下層剥離術(endoscopic submucosal dissection:ESD)を施行、最深病変の病理組織診断は、扁平上皮癌、pT1a-MM、ly(-)、v(-)であった。ESD3週間後に、アカラシアに対して、内視鏡的バルーン拡張術を施行した。アカラシアおよび多発表在型食道癌に対して、内視鏡治療が可能であった1例を経験したので報告する。(著者抄録)

  • 食道内視鏡的粘膜下層剥離術の直後にトリアムシノロンを局注した患者における術後狭窄の予測(Prediction of esophageal stricture in patients given locoregional triamcinolone injections immediately after endoscopic submucosal dissection) Reviewed

    Nagami Yasuaki, Ominami Masaki, Shiba Masatsugu, Sakai Taishi, Fukunaga Shusei, Sugimori Satoshi, Otani Koji, Hosomi Shuhei, Tanaka Fumio, Taira Koichi, Kamata Noriko, Yamagami Hirokazu, Tanigawa Tetsuya, Watanabe Toshio, Ishihara Takuma, Yamamoto Kouji, Fujiwara Yasuhiro

    John Wiley & Sons Australia, Ltd Digestive Endoscopy   30 ( 2 )   198 - 205   2018.03( ISSN:0915-5635

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    表在型食道癌に対する内視鏡的粘膜下層剥離術(ESD)の直後にトリアムシノロンを局所注入した患者を対象に、術後狭窄の予測因子について検討した。対象は食道ESD後の狭窄予防を目的にトリアムシノロンを局注した一括切除101件(患者96例)で、それ以外の狭窄予防を施行した症例は除外した。術後狭窄は17件(16.8%)で発生した。症例を狭窄17件(男性15例、女性2例、平均69.4±5.3歳)と狭窄なし84件(男性67例、女性17例、平均69.9±8.7歳)の2群に分類した。術後狭窄群は狭窄なし群に比べて病変の縦径が有意に大きく、粘膜欠損の範囲が有意に広かった。多重ロジスティック回帰分析の結果、広範囲な粘膜欠損が術後狭窄を予測する独立因子であった(オッズ比2.42、95%信頼区間1.01〜5.80、P=0.048)。ROC曲線解析で粘膜欠損のカットオフ値を5/6周性と設定した場合の術後狭窄の予測感度は69.0%、特異度は64.7%であった。

  • 食道扁平上皮癌に対する内視鏡的粘膜下層剥離術におけるプロポフォールとミダゾラムの比較 無作為化比較対照試験(Comparison of propofol with midazolam in endoscopic submucosal dissection for esophageal squamous cell carcinoma: a randomized controlled trial) Reviewed

    Ominami Masaki, Nagami Yasuaki, Shiba Masatsugu, Tominaga Kazunari, Sakai Taishi, Maruyama Hirotsugu, Kato Kunihiro, Minamino Hiroaki, Fukunaga Shusei, Tanaka Fumio, Sugimori Satoshi, Kamata Noriko, Machida Hirohisa, Yamagami Hirokazu, Tanigawa Tetsuya, Watanabe Toshio, Fujiwara Yasuhiro, Arakawa Tetsuo

    シュプリンガー・ジャパン(株) Journal of Gastroenterology   53 ( 3 )   397 - 406   2018.03( ISSN:0944-1174

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    食道扁平上皮癌(ESCC)に対する内視鏡的粘膜下層剥離術(ESD)時の鎮静におけるプロポフォールの有効性と安全性をミダゾラムと比較した。ESDを要するESCC患者132例をミダゾラム群66例(女性12例、男性54例、平均70.1±8.8歳)とプロポフォール群66例(女性14例、男性52例、平均69.5±8.2歳)に無作為に割り付け、鎮静不良によるESDの中断率と鎮静不良の危険因子を調べた。鎮静不良によるESDの中断率は、プロポフォール群で0%、ミダゾラム群で37.9%であった。多重ロジスティック回帰分析では、若年、ミダゾラムの使用が鎮静不良の独立危険因子であった。鎮痛時間は両群間で有意差がなかった。ミダゾラム群よりもプロポフォール群で低血圧が頻繁に発生した。有害事象発生率は両群間で同等であった。プロポフォールはミダゾラムよりもESCCに対するESD時の鎮静に効果的であった。

  • Efficacy of a concomitant elemental diet to reduce the loss of response to adalimumab in patients with intractable Crohn's disease Reviewed

    Sugita Naoko, Watanabe Kenji, Kamata Noriko, Yukawa Tomomi, Otani Koji, Hosomi Shuhei, Nagami Yasuaki, Tanaka Fumio, Taira Koichi, Yamagami Hirokazu, Tanigawa Tetsuya, Shiba Masatsugu, Watanabe Toshio, Tominaga Kazunari, Kabata Daijiro, Shintani Ayumi, Arakawa Tetsuo, Fujiwara Yasuhiro

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   33 ( 3 )   631 - 637   2018.03( ISSN:0815-9319

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/jgh.13969

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  • Prediction of esophageal stricture in patients given locoregional triamcinolone injections immediately after endoscopic submucosal dissection Reviewed

    Nagami Yasuaki, Ominami Masaki, Shiba Masatsugu, Sakai Taishi, Fukunaga Shusei, Sugimori Satoshi, Otani Koji, Hosomi Shuhei, Tanaka Fumio, Taira Koichi, Kamata Noriko, Yamagami Hirokazu, Tanigawa Tetsuya, Watanabe Toshio, Ishihara Takuma, Yamamoto Kouji, Fujiwara Yasuhiro

    DIGESTIVE ENDOSCOPY   30 ( 2 )   198 - 205   2018.03( ISSN:0915-5635

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/den.12946

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  • Comparison of propofol with midazolam in endoscopic submucosal dissection for esophageal squamous cell carcinoma: a randomized controlled trial Reviewed

    Ominami Masaki, Nagami Yasuaki, Shiba Masatsugu, Tominaga Kazunari, Sakai Taishi, Maruyama Hirotsugu, Kato Kunihiro, Minamino Hiroaki, Fukunaga Shusei, Tanaka Fumio, Sugimori Satoshi, Kamata Noriko, Machida Hirohisa, Yamagami Hirokazu, Tanigawa Tetsuya, Watanabe Toshio, Fujiwara Yasuhiro, Arakawa Tetsuo

    JOURNAL OF GASTROENTEROLOGY   53 ( 3 )   397 - 406   2018.03( ISSN:0944-1174

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00535-017-1358-6

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  • 卵巣癌原発の転移性胃腫瘍(A Metastatic Gastric Tumor from Ovarian Cancer) Reviewed

    Kono Mitsuhiro, Nagami Yasuaki, Ominami Masaki, Sakai Taishi, Fukuda Takeshi, Fukunaga Shusei, Tanaka Fumio, Sugimori Satoshi, Yamagami Hirokazu, Tanigawa Tetsuya, Shiba Masatsugu, Tominaga Kazunari, Watanabe Toshio, Fujiwara Yasuhiro, Arakawa Tetsuo

    (一社)日本内科学会 Internal Medicine   57 ( 3 )   345 - 349   2018.02( ISSN:0918-2918

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    症例は64歳女性で、高血圧、糖尿病、慢性腎不全の病歴があり、両側卵巣腫瘍のため当院に入院となった。身体検査で眼瞼結膜貧血、下肢浮腫、下腹部に圧痛を伴う腫瘍が認められ、MRIで右卵巣に13cm、左卵巣に6cmの嚢胞性腫瘤が検出された。胸部-骨盤部の単純CTまたは骨盤MRIでは転移は認められなかったが、診断および病期確定目的で開腹術を施行した際の迅速病理診断で右卵巣の粘液癌が明らかになった。両側卵管卵巣摘出術、単純子宮摘出術、骨盤・傍大動脈リンパ節郭清、大網部分切除術を施行した。転移や血管/リンパ管浸潤はみられず、ステージIA卵巣癌と診断した。術後1ヵ月時に背部痛が出現し、腫瘍マーカーが再度上昇したためシンチグラフィーを行ったところ、骨転移を検出した。食道胃十二指腸内視鏡検査で胃内に頂点部が潰瘍化した10mmの隆起病変が認められ、生検検体の免疫染色により本病変は卵巣癌の転移病変であることが示された。化学療法を追加したが、3ヵ月後に死亡した。

  • Risk of pancreatitis after pancreatic duct guidewire placement during endoscopic retrograde cholangiopancreatography Reviewed

    Ishikawa-Kakiya Yuki, Shiba Masatsugu, Maruyama Hirotsugu, Kato Kunihiro, Fukunaga Shusei, Sugimori Satoshi, Otani Koji, Hosomi Shuhei, Tanaka Fumio, Nagami Yasuaki, Taira Koichi, Yamagami Hirokazu, Tanigawa Tetsuya, Watanabe Toshio, Fujiwara Yasuhiro

    PLOS ONE   13 ( 1 )   e0190379   2018.01( ISSN:1932-6203

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    DOI: 10.1371/journal.pone.0190379

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  • Sepsis Markers Soluble IL-2 Receptor and Soluble CD14 Subtype as Potential Biomarkers for Complete Mucosal Healing in Patients With Inflammatory Bowel Disease Reviewed

    Hosomi Shuhei, Yamagami Hirokazu, Itani Shigehiro, Yukawa Tomomi, Otani Koji, Nagami Yasuaki, Tanaka Fumio, Taira Koichi, Kamata Noriko, Tanigawa Tetsuya, Shiba Masatsugu, Watanabe Toshio, Fujiwara Yasuhiro

    JOURNAL OF CROHNS & COLITIS   12 ( 1 )   87 - 95   2018.01( ISSN:1873-9946

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    DOI: 10.1093/ecco-jcc/jjx124

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  • A CASE OF MULTIPLE SUPERFICIAL ESOPHAGEAL CANCERS ASSOCIATED WITH ACHALASIA OF THE ESOPHAGUS TREATED BY ENDOSCOPIC SUBMUCOSAL DISSECTION Reviewed

    MARUYAMA Hirotsugu, ARAKAWA Tetsuo, TOMINAGA Kazunari, SAKAI Taishi, OMINAMI Masaki, NAGAMI Yasuaki, SUGIMORI Satoshi, SHIBA Masatsugu, WATANABE Toshio, FUJIWARA Yasuhiro

    Japan Gastroenterological Endoscopy Society, GASTROENTEROLOGICAL ENDOSCOPY   60 ( 5 )   1076 - 1082   2018( ISSN:0387-1207

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    <p>We performed endoscopic submucosal dissection (ESD) for multiple superficial esophageal cancers in a case coexisting with esophageal achalasia. The patient was a 55-year-old man who suffered from dysphagia for the past 18 years. He was diagnosed as having esophageal achalasia by various imaging examinations that revealed the morphology and function of the esophagus. Then, screening esophagogastroduodenoscopy detected multiple superficial esophageal cancers at the upper part (1 lesion) and the middle part (5 lesions) of the esophagus. All esophageal lesions at the upper and middle parts of the esophagus in the patient who had already been diagnosed with esophageal achalasia, were successfully removed by ESD. Pathological examination showed squamous cell carcinoma for three lesions and high-grade intraepithelial neoplasia for the other three lesions. Immunostaining for p53 showed positivity in not only cancer cells but also non-cancerous cells. In this case, it is likely that prolonged mechanical and chemical irritations due to achalasia led to a p53 mutation and resulted in the development of cancer. It is important to carry out careful long-term follow-up for patients with achalasia to detect esophageal cancer as soon as possible. We herein report such a patient with a review of the relevant literature.</p>

    DOI: 10.11280/gee.60.1076

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  • Basic Study on <i>In Vivo</i> 3D Micro-tomographic Visualization of Vascular Plexuses and Capillary Blood Flow Using Optical Coherence Doppler Velocigraphy Reviewed

    FURUKAWA Daisuke, KUSUMOTO Naoya, SAEKI Souichi, Aoki Susumu, ITO Takafumi, NISHINO Yoshiaki, HARA Yusuke, SHIBA Masatsugu

    The Japan Society of Mechanical Engineers, The Proceedings of the Bioengineering Conference Annual Meeting of BED/JSME   2018 ( 0 )   2018

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    DOI: 10.1299/jsmebio.2018.30.2I06

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  • A Metastatic Gastric Tumor from Ovarian Cancer Reviewed

    Kono Mitsuhiro, Nagami Yasuaki, Ominami Masaki, Sakai Taishi, Fukuda Takeshi, Fukunaga Shusei, Tanaka Fumio, Sugimori Satoshi, Yamagami Hirokazu, Tanigawa Tetsuya, Shiba Masatsugu, Tominaga Kazunari, Watanabe Toshio, Fujiwara Yasuhiro, Arakawa Tetsuo

    一般社団法人 日本内科学会 INTERNAL MEDICINE   57 ( 3 )   345 - 349   2018( ISSN:0918-2918

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    <p>Gastric metastasis from ovarian cancer has rarely been reported. We herein report the case of a 64-year-old woman with gastric metastasis from ovarian cancer that was diagnosed as surgical stage IA. Diagnostic and staging laparotomy showed mucinous carcinoma of the right ovary. At one month after surgery, bone metastasis was detected via scintigraphy. On esophagogastroduodenoscopy, a 10-mm elevated lesion with ulceration on the top was seen in the stomach. The immunohistochemical analysis of biopsy specimens showed that these metastases arose from ovarian cancer. We recommend that physicians remain aware of the possibility of gastric metastasis in patients with ovarian cancer. </p>

    DOI: 10.2169/internalmedicine.9147-17

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  • Clinical Utility of Capsule Endoscopy and Double-Balloon Enteroscopy in the Management of Obscure Gastrointestinal Bleeding Reviewed

    Otani Koji, Watanabe Toshio, Shimada Sunao, Hosomi Shuhei, Nagami Yasuaki, Tanaka Fumio, Kamata Noriko, Taira Koichi, Yamagami Hirokazu, Tanigawa Tetsuya, Shiba Masatsugu, Fujiwara Yasuhiro

    DIGESTION   97 ( 1 )   52 - 58   2018( ISSN:0012-2823

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    DOI: 10.1159/000484218

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  • Endoscopic Submucosal Dissection for Adenocarcinomas of the Esophagogastric Junction Reviewed

    Nagami Yasuaki, Ominami Masaki, Otani Koji, Hosomi Shuhei, Tanaka Fumio, Taira Koichi, Kamata Noriko, Yamagami Hirokazu, Tanigawa Tetsuya, Shiba Masatsugu, Watanabe Toshio, Fujiwara Yasuhiro

    DIGESTION   97 ( 1 )   38 - 44   2018( ISSN:0012-2823

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    DOI: 10.1159/000484111

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  • Safety and efficacy of transpapillary bridged bilateral side-by-side stenting for unresectable malignant hilar biliary obstruction Reviewed

    Maruyama Hirotsugu, Tominaga Kazunari, Kato Kunihiro, Sugimori Satoshi, Shiba Masatsugu, Watanabe Toshio, Fujiwara Yasuhiro

    HEPATOBILIARY & PANCREATIC DISEASES INTERNATIONAL   16 ( 6 )   659 - 661   2017.12( ISSN:1499-3872

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    DOI: 10.1016/S1499-3872(17)60072-9

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  • Brushing the distal biliary stricture in the surrounding of the papilla increased the risk of post-endoscopic retrograde cholangiopancreatography pancreatitis: A retrospective study using propensity score analysis Reviewed

    Kato Kunihiro, Sugimori Satoshi, Kakiya Yuki, Maruyama Hirotsugu, Fukunaga Shusei, Nagami Yasuaki, Shiba Masatsugu, Tanigawa Tetsuya, Watanabe Toshio, Fujiwara Yasuhiro

    UNITED EUROPEAN GASTROENTEROLOGY JOURNAL   5 ( 7 )   1015 - 1023   2017.11( ISSN:2050-6406

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    DOI: 10.1177/2050640617694279

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  • クローン病の小腸狭窄に対するダブルバルーン内視鏡を用いた内視鏡的バルーン拡張術後の外科的危険因子の解析(Analysis of the Risk Factors of Surgery after Endoscopic Balloon Dilation for Small Intestinal Strictures in Crohn's Disease Using Double-balloon Endoscopy) Reviewed

    Nishida Yu, Hosomi Shuhei, Yamagami Hirokazu, Yukawa Tomomi, Nagami Yasuaki, Tanaka Fumio, Kamata Noriko, Tanigawa Tetsuya, Shiba Masatsugu, Watanabe Toshio, Tominaga Kazunari, Fujiwara Yasuhiro, Arakawa Tetsuo

    (一社)日本内科学会 Internal Medicine   56 ( 17 )   2245 - 2252   2017.09( ISSN:0918-2918

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    2006〜2015年にクローン病の小腸狭窄に対してダブルバルーン内視鏡(DBE)による内視鏡的バルーン拡張術(EBD)を施行した患者37例(男性31例、女性6例、診断時年齢20.5〜28.4歳)の長期転帰を後向きに評価した。さらに、その後の外科的介入の必要性と関連する危険因子を特定した。37例に対してDBEによるEBDが72セッション(112回)行われた。18例(48.6%)がフォローアップ中に手術を必要とした。多変量解析において外科手術の必要性と関連する有意な因子は複数の狭窄であった。狭窄が一ヶ所の患者15例のうちの1例(6.7%)で手術が必要となり、複数の狭窄を有する患者22例では17例(77.3%)で手術が必要となった。一ヶ所の狭窄は、クローン病患者の小腸狭窄に対するDBEによるEBDの良好な指標となり得ることが示唆された。

  • A comparison of short-term therapeutic efficacy between infliximab and tacrolimus for moderate to severe ulcerative colitis Reviewed

    Yamagami Hirokazu, Nishida Yu, Nagami Yasuaki, Hosomi Shuhei, Yukawa Tomomi, Otani Koji, Tanaka Fumio, Taira Koichi, Kamata Noriko, Tanigawa Tetsuya, Shiba Masatsugu, Watanabe Toshio, Fujiwara Yasuhiro

    ROMANIAN JOURNAL OF INTERNAL MEDICINE   55 ( 3 )   151 - 157   2017.09( ISSN:1582-3296

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    DOI: 10.1515/rjim-2017-0012

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  • Celecoxib Oral Administration for Prevention of Post-Endoscopic Retrograde Cholangiopancreatography Pancreatitis A Randomized Prospective Trial Reviewed

    Kato Kunihiro, Shiba Masatsugu, Kakiya Yuki, Maruyama Hirotsugu, Ominami Masaki, Fukunaga Shusei, Sugimori Satoshi, Nagami Yasuaki, Watanabe Toshio, Tominaga Kazunari, Fujiwara Yasuhiro

    PANCREAS   46 ( 7 )   880 - 886   2017.08( ISSN:0885-3177

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    DOI: 10.1097/MPA.0000000000000852

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  • The Predictive Factor for Esophageal Stricture in Patients Who Received Locoregional Triamcinolone Injection Immediately After ESD Reviewed

    Nagami Yasuaki, Ominami Masaki, Shiba Masatsugu, Sakai Taishi, Fukunaga Shusei, Sugimori Satoshi, Otani Koji, Hosomi Shuhei, Tanaka Fumio, Kamata Noriko, Yamagami Hirokazu, Tanigawa Tetsuya, Watanabe Toshio, Fujiwara Yasuhiro

    GASTROINTESTINAL ENDOSCOPY   85 ( 5 )   AB577 - AB577   2017.05( ISSN:0016-5107

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  • Usefulness of Small Intestinal Reexamination for Patients With Obscure Gastrointestinal Bleeding With Negative Capsule Endoscopy Findings: Comparison of Balloon-Assisted Enteroscopy and Capsule Endoscopy Reviewed

    Otani Koji, Watanabe Toshio, Shiba Masatsugu, Sugimura Naoki, Itani Shigehiro, Shimada Sunao, Nadatani Yuji, Hosomi Shuhei, Nagami Yasuaki, Tanaka Fumio, Taira Koichi, Kamata Noriko, Yamagami Hirokazu, Tanigawa Tetsuya, Fujiwara Yasuhiro

    GASTROINTESTINAL ENDOSCOPY   85 ( 5 )   AB297 - AB298   2017.05( ISSN:0016-5107

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  • Long-Term Outcome of Endoscopic Submucosal Dissection for Early Gastric Cancer in Patients With Severe Comorbidities: A Comparative Propensity Score Analysis Reviewed

    Tanoue Koujiro, Fukunaga Shusei, Nagami Yasuaki, Nakamura Yoshihiro, Kakiya Yuki, Hayashi Kappei, Kinoshita Yosuke, Sakai Taishi, Maruyama Hirotsugu, Kato Kunihiro, Ominami Masaki, Sugimori Satoshi, Otani Koji, Hosomi Shuhei, Tanaka Fumio, Taira Koichi, Kamata Noriko, Yamagami Hirokazu, Tanigawa Tetsuya, Shiba Masatsugu, Watanabe Toshio, Fujiwara Yasuhiro

    GASTROINTESTINAL ENDOSCOPY   85 ( 5 )   AB429 - AB430   2017.05( ISSN:0016-5107

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  • Does Discontinuation of Antithrombotic Agents Affect Diagnostic Yield of Small Bowel Capsule Endoscopy in Patients With Obscure Gastrointestinal Bleeding? Reviewed

    Watanabe Toshio, Shimada Sunao, Nadatani Yuji, Otani Koji, Tanaka Fumio, Nagami Yasuaki, Kamata Noriko, Yamagami Hirokazu, Tanigawa Tetsuya, Shiba Masatsugu, Miyazaki Takako, Nakamura Shiro, Fujiwara Yasuhiro

    GASTROINTESTINAL ENDOSCOPY   85 ( 5 )   AB293 - AB294   2017.05( ISSN:0016-5107

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  • The five-year survival rate after endoscopic submucosal dissection for superficial esophageal squamous cell neoplasia Reviewed

    Nagami Yasuaki, Ominami Masaki, Shiba Masatsugu, Minamino Hiroaki, Fukunaga Shusei, Kameda Natsuhiko, Sugimori Satoshi, Machida Hirohisa, Tanigawa Tetsuya, Yamagami Hirokazu, Watanabe Toshio, Tominaga Kazunari, Fujiwara Yasuhiro, Arakawa Tetsuo

    DIGESTIVE AND LIVER DISEASE   49 ( 4 )   427 - 433   2017.04( ISSN:1590-8658

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    DOI: 10.1016/j.dld.2016.12.009

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  • Hyperbolic span and pseudoconvexity Reviewed

    Hamano Sachiko, Shiba Masakazu, Yamaguchi Hiroshi

    KYOTO JOURNAL OF MATHEMATICS   57 ( 1 )   165 - 183   2017.04( ISSN:2156-2261

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    DOI: 10.1215/21562261-3759558

  • Neutrophil-to-lymphocyte ration in ulcerative colitis predicts sustained response to infliximab Reviewed

    Nishida Y., Hosomi S., Watanabe K., Yukawa T., Otani K., Nagami Y., Tanaka F., Taira K., Kamata N., Shiba M., Yamagami H., Tanigawa T., Watanabe T., Tominaga K., Fujiwara Y.

    JOURNAL OF CROHNS & COLITIS   11   S294 - S294   2017.02( ISSN:1873-9946

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  • Single Locoregional Triamcinolone Injection Immediately After Esophageal Endoscopic Submucosal Dissection Prevents Stricture Formation Reviewed

    Nagami Yasuaki, Shiba Masatsugu, Ominami Masaki, Sakai Taishi, Minamino Hiroaki, Fukunaga Shusei, Sugimori Satoshi, Tanaka Fumio, Kamata Noriko, Tanigawa Tetsuya, Yamagami Hirokazu, Watanabe Toshio, Tominaga Kazunari, Fujiwara Yasuhiro, Arakawa Tetsuo

    CLINICAL AND TRANSLATIONAL GASTROENTEROLOGY   8 ( 2 )   e75   2017.02( ISSN:2155-384X

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    DOI: 10.1038/ctg.2017.5

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  • Neutrophil-to-Lymphocyte Ratio for Predicting Loss of Response to Infliximab in Ulcerative Colitis Reviewed

    Nishida Yu, Hosomi Shuhei, Yamagami Hirokazu, Yukawa Tomomi, Otani Koji, Nagami Yasuaki, Tanaka Fumio, Taira Koichi, Kamata Noriko, Tanigawa Tetsuya, Shiba Masatsugu, Watanabe Kenji, Watanabe Toshio, Tominaga Kazunari, Fujiwara Yasuhiro

    PLOS ONE   12 ( 1 )   e0169845   2017.01( ISSN:1932-6203

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    DOI: 10.1371/journal.pone.0169845

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  • Long-term prognosis of expanded-indication differentiated-type early gastric cancer treated with endoscopic submucosal dissection or surgery using propensity score analysis Reviewed

    Fukunaga Shusei, Nagami Yasuaki, Shiba Masatsugu, Ominami Masaki, Tanigawa Tetsuya, Yamagami Hirokazu, Tanaka Hiroaki, Muguruma Kazuya, Watanabe Toshio, Tominaga Kazunari, Fujiwara Yasuhiro, Ohira Masaichi, Hirakawa Kosei, Arakawa Tetsuo

    GASTROINTESTINAL ENDOSCOPY   85 ( 1 )   143 - 152   2017.01( ISSN:0016-5107

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    DOI: 10.1016/j.gie.2016.06.049

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  • Study on Dependency of Capillary Blood Flow Velocity on Peripheral Vasodilator using Micro -tomographic Visualization of Doppler Velocity (OCDV) Reviewed

    FURUKAWA Daisuke, SAEKI Souichi, KUSUMOTO Naoya, HARA Yusuke, AOKI Susumu, ITO Takafumi, NISHINO Yoshiaki, SHIBA Masatsugu

    The Japan Society of Mechanical Engineers, The Proceedings of Mechanical Engineering Congress, Japan   2017 ( 0 )   2017

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    <p>Rheological behavior of interstitial fluid in epidermal and dermal tissue, including blood micro-circulation, can vary skin mechanics in micro scale, i.e. visco-elasticity. Therefore, an <i>in vivo</i> quantitative measurement of capillary blood flow velocity is crucial to clarify their properties. The purpose of this study is to visualize the tomographic flow velocity of red blood cell in capillaries of human epidermal skin using Optical Coherence Doppler Velocigraphy, i.e. OCDV. This is constructed on a high frequency modulated low coherence interferometer, which is based on Hilbert transform and adjacent auto-correlation. In order to confirm the utility of OCDV, the tomographic distribution of capillary blood flow velocity was diagnosed with or without a vasodilator drug. As a result of <i>in vivo</i> applying OCDV to human cheek skins, this can reveal the vasodilation effect as well as the change of the blood flow velocity as an <i>in vivo</i> tomographic imaging.</p>

    DOI: 10.1299/jsmemecj.2017.J0210104

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  • Time course study on the capillary blood flow velocity under the epidermis using micro-tomographic visualizating technique Reviewed

    Furukawa Daisuke, Saeki Souichi, Kusumoto Naoya, Nishino Ryohei, Hara Yusuke, Aoki Susumu, Ito Takafumi, Nishino Yoshiaki, Shiba Masatsugu

    Japanese Society for Medical and Biological Engineering, Transactions of Japanese Society for Medical and Biological Engineering   55 ( 4 )   323 - 323   2017( ISSN:1347-443X

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    <p>The skin aging process caused by not only aging but also ultraviolet irradiation, could be related to the depression of metabolic function. The microcirculation system should be an important guideline of skin care for anti-aging. Rheological behavior of interstitial in epidermal and dermal tissue, including blood micro-circulation, can vary skin mechanics in micro scale, i.e. visco-elasticity. The purpose of this study is to visualize the tomographic flow velocity of red blood cell in capillaries below human epidermal skin using Optical Coherence Doppler Velocigraphy (OCDV). In order to validate OCDV system, this was in vivo applied to human forearm skin just after releasing a tourniquet. Consequently, time course of capillary blood flow velocity, visualized by OCDV system, could be evaluated tomographically in terms of reperfusion around epidermis and dermis.</p>

    DOI: 10.11239/jsmbe.55Annual.323

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  • Microbiota Plays a Key Role in Non-Steroidal Anti-Inflammatory Drug-Induced Small Intestinal Damage Reviewed

    Otani Koji, Tanigawa Tetsuya, Watanabe Toshio, Shimada Sunao, Nadatani Yuji, Nagami Yasuaki, Tanaka Fumio, Kamata Noriko, Yamagami Hirokazu, Shiba Masatsugu, Tominaga Kazunari, Fujiwara Yasuhiro, Arakawa Tetsuo

    DIGESTION   95 ( 1 )   22 - 28   2017( ISSN:0012-2823

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    DOI: 10.1159/000452356

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  • A comparison between capsule endoscopy and double balloon enteroscopy using propensity score-matching analysis in patients with previous obscure gastrointestinal bleeding Reviewed

    Kakiya Yuki, Shiba Masatsugu, Okamoto Junichi, Kato Kunihiro, Minamino Hiroaki, Ominami Masaki, Fukunaga Shusei, Nagami Yasuaki, Sugimori Satoshi, Tanigawa Tetsuya, Yamagami Hirokazu, Watanabe Toshio, Tominaga Kazunari, Fujiwara Yasuhiro, Arakawa Tetsuo

    SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY   52 ( 3 )   306 - 311   2017( ISSN:0036-5521

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    DOI: 10.1080/00365521.2016.1253766

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  • Analysis of the Risk Factors of Surgery after Endoscopic Balloon Dilation for Small Intestinal Strictures in Crohn's Disease Using Double-balloon Endoscopy Reviewed

    Nishida Yu, Hosomi Shuhei, Yamagami Hirokazu, Yukawa Tomomi, Nagami Yasuaki, Tanaka Fumio, Kamata Noriko, Tanigawa Tetsuya, Shiba Masatsugu, Watanabe Toshio, Tominaga Kazunari, Fujiwara Yasuhiro, Arakawa Tetsuo

    一般社団法人 日本内科学会 INTERNAL MEDICINE   56 ( 17 )   2245 - 2252   2017( ISSN:0918-2918

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    <p><b>Objective </b>Balloon-assisted endoscopy enables access to and treatment of strictures in the small intestine using endoscopic balloon dilation (EBD); however, the long-term outcomes of EBD have not been sufficiently evaluated. This study evaluated the long-term outcomes of EBD in Crohn's disease to identify the risk factors associated with the need for subsequent surgical intervention. </p><p><b>Methods </b>We retrospectively analyzed patients with Crohn's disease who had undergone EBD with double-balloon endoscopy (DBE) for small intestinal strictures at a single center between 2006 and 2015. The long-term outcomes were assessed based on the cumulative surgery-free rate following initial EBD. </p><p><b>Results </b>Seventy-two EBD with DBE sessions and 112 procedures were performed for 37 patients during this period. Eighteen patients (48.6%) required surgery during follow-up. Significant factors associated with the need for surgery in a multivariate analysis were multiple strictures (adjusted hazard ratio, 14.94; 95% confidence interval, 1.91-117.12; p=0.010). One patient (6.7%) required surgery among 15 who had single strictures compared to 17 (77.3%) among 22 patients with multiple strictures. </p><p><b>Conclusion </b>In a multivariate analysis, the presence of multiple strictures was a significant risk factor associated with the need for surgery; therefore, a single stricture might be a good indication for EBD using DBE for small intestinal strictures in Crohn's disease patients. </p>

    DOI: 10.2169/internalmedicine.8224-16

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  • Clinical factors associated with positive capsule endoscopy findings in patients with obscure gastrointestinal bleeding: a single-center study Reviewed

    Shimada Sunao, Watanabe Toshio, Nadatani Yuji, Otani Koji, Taira Koichi, Hosomi Shuhei, Nagami Yasuaki, Tanaka Fumio, Kamata Noriko, Yamagami Hirokazu, Tanigawa Tetsuya, Shiba Masatsugu, Fujiwara Yasuhiro

    SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY   52 ( 11 )   1219 - 1223   2017( ISSN:0036-5521

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    DOI: 10.1080/00365521.2017.1349174

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  • NLRP3 inflammasome has a protective effect against oxazolone-induced colitis: a possible role in ulcerative colitis Reviewed

    Itani Shigehiro, Watanabe Toshio, Nadatani Yuji, Sugimura Naoki, Shimada Sunao, Takeda Shogo, Otani Koji, Hosomi Shuhei, Nagami Yasuaki, Tanaka Fumio, Kamata Noriko, Yamagami Hirokazu, Tanigawa Tetsuya, Shiba Masatsugu, Tominaga Kazunari, Fujiwara Yasuhiro, Arakawa Tetsuo

    SCIENTIFIC REPORTS   6   39075   2016.12( ISSN:2045-2322

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    DOI: 10.1038/srep39075

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  • Concentration of Glial Cell Line-Derived Neurotrophic Factor Positively Correlates with Symptoms in Functional Dyspepsia Reviewed

    Tanaka Fumio, Tominaga Kazunari, Fujikawa Yoshiko, Nagami Yasuaki, Kamata Noriko, Yamagami Hirokazu, Tanigawa Tetsuya, Shiba Masatsugu, Watanabe Toshio, Fujiwara Yasuhiro, Arakawa Tetsuo

    DIGESTIVE DISEASES AND SCIENCES   61 ( 12 )   3478 - 3485   2016.12( ISSN:0163-2116

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    DOI: 10.1007/s10620-016-4329-5

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  • Lithotomy is associated with moderate to severe post-endoscopic retrograde cholangiopancreatography pancreatitis using inverse probability of treatment weighting Reviewed

    Sugimori Satoshi, Shiba Masatsugu, Maruyama Hirotsugu, Kato Kunihiro, Nagami Yasuaki, Tanigawa Tetsuya, Watanabe Toshio, Tominaga Kazunari, Fujiwara Yasuhiro

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   31   249 - 249   2016.11( ISSN:0815-9319

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  • Alteration of Esophageal Microbiome by Antibiotic Treatment Does Not Affect Incidence of Rat Esophageal Adenocarcinoma Reviewed

    Sawada Akinari, Fujiwara Yasuhiro, Nagami Yasuaki, Tanaka Fumio, Yamagami Hirokazu, Tanigawa Tetsuya, Shiba Masatsugu, Tominaga Kazunari, Watanabe Toshio, Gi Min, Wanibuchi Hideki, Arakawa Tetsuo

    DIGESTIVE DISEASES AND SCIENCES   61 ( 11 )   3161 - 3168   2016.11( ISSN:0163-2116

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    DOI: 10.1007/s10620-016-4263-6

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  • Is heparin bridging therapy associated with post-colorectal polypectomy bleeding in patients with interrupted oral anticoagulation therapy? Reviewed

    Sakai Taishi, Nagami Yasuaki, Shiba Masatsugu, Ominami Masaki, Fukunaga Shusei, Tanigawa Tetsuya, Watanabe Toshio, Tominaga Kazunari, Fujiwara Yasuhiro

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   31   185 - 185   2016.11( ISSN:0815-9319

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  • Sleep disturbances in Japanese patients with inflammatory bowel disease and their impact on disease flare Reviewed

    Uemura Risa, Fujiwara Yasuhiro, Iwakura Narika, Shiba Masatsugu, Watanabe Kenji, Kamata Noriko, Yamagami Hirokazu, Tanigawa Tetsuya, Watanabe Toshio, Tominaga Kazunari, Arakawa Tetsuo

    SPRINGERPLUS   5 ( 1 )   1792   2016.10( ISSN:2193-1801

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    DOI: 10.1186/s40064-016-3408-6

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  • Double-balloon endoscopy WAS effective in diagnosing small intestinal duplication: a case report Reviewed

    Nadatani Yuji, Watanabe Toshio, Sugawa Takashi, Eguchi Shinpei, Shimada Sunao, Otani Koji, Yamagami Hirokazu, Tanigawa Tetsuya, Shiba Masatsugu, Tominaga Kazunari, Fujiwara Yasuhiro, Arakawa Tetsuo

    SPRINGERPLUS   5 ( 1 )   1598   2016.09( ISSN:2193-1801

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    DOI: 10.1186/s40064-016-3256-4

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  • Colchicine prevents NSAID-induced small intestinal injury by inhibiting activation of the NLRP3 inflammasome Reviewed

    Otani Koji, Watanabe Toshio, Shimada Sunao, Takeda Shogo, Itani Shigehiro, Higashimori Akira, Nadatani Yuji, Nagami Yasuaki, Tanaka Fumio, Kamata Noriko, Yamagami Hirokazu, Tanigawa Tetsuya, Shiba Masatsugu, Tominaga Kazunari, Fujiwara Yasuhiro, Arakawa Tetsuo

    SCIENTIFIC REPORTS   6   32587   2016.09( ISSN:2045-2322

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    DOI: 10.1038/srep32587

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  • Hybrid therapy with locoregional steroid injection and polyglycolic acid sheets to prevent stricture after esophageal endoscopic submucosal dissection Reviewed

    Nagami Yasuaki, Shiba Masatsugu, Tominaga Kazunari, Ominami Masaki, Fukunaga Shusei, Sugimori Satoshi, Tanaka Fumio, Kamata Noriko, Tanigawa Tetsuya, Yamagami Hirokazu, Watanabe Toshio, Fujiwara Yasuhiro, Arakawa Tetsuo

    ENDOSCOPY INTERNATIONAL OPEN   4 ( 9 )   E1017 - E1022   2016.09( ISSN:2364-3722

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    DOI: 10.1055/s-0042-111906

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  • A Case of Non-Swelling Autoimmune Pancreatitis with Multiple Pancreatic Pseudocysts Reviewed

    Maruyama Hirotsugu, Tominaga Kazunari, Kato Kunihiro, Nagami Yasuaki, Sugimori Satoshi, Shiba Masatsugu, Watanabe Toshio, Fujiwara Yasuhiro, Kubo Yuki, Ohsawa Masahiko

    JOURNAL OF THE PANCREAS   17 ( 5 )   543 - 548   2016.09( ISSN:1590-8577

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  • 胃食道逆流症患者における睡眠障害の特徴(Characteristics of Sleep Disturbances in Patients with Gastroesophageal Reflux Disease) Reviewed

    Iwakura Narika, Fujiwara Yasuhiro, Shiba Masatsugu, Ochi Masahiro, Fukuda Takashi, Tanigawa Tetsuya, Yamagami Hirokazu, Tominaga Kazunari, Watanabe Toshio, Arakawa Tetsuo

    (一社)日本内科学会 Internal Medicine   55 ( 12 )   1511 - 1517   2016.06( ISSN:0918-2918

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    胃食道逆流症(GERD)患者と非GERD患者の睡眠障害の特徴を、数種類の自記式質問票を用いて比較した。GERDの外来成人患者124例(GERD群)と、GERD症状は認めないが表在性胃癌または結腸ポリープの内視鏡切除を施行した外来患者226例(非GERD群)に、ピッツバーグ睡眠質問票(PSQI)、不安・抑うつ尺度(HADS)、不眠重症度指数(ISI)、エプワース眠気尺度(ESS)、8-item Short-Form Health Survey(SF-8)に回答してもらった。PSQI>5.5を睡眠障害と判定した。その結果、睡眠障害の有病率は非GERD群(39.3%)よりもGERD群(53.9%)が有意に高かった。不安・抑うつの有病率は睡眠障害を呈する患者で有意に高かったが、GERD群と非GERD群間では差がなかった。睡眠障害を呈する患者のうち、日中の眠気は非GERD群よりもGERD群で多く認められた。睡眠障害を呈する患者は健康関連QOLが不良であった。睡眠障害を呈するGERD患者は、日中の眠気を経験している場合が多く、健康関連QOLの特に身体的側面が不良であることが示唆された。

  • Use of PGA Sheets in the Endoscopic Closure of a Perforation After Endoscopic Submucosal Dissection for Gastric-Tube Cancer Reviewed

    Nagami Yasuaki, Shiba Masatsugu, Arakawa Tetsuo

    AMERICAN JOURNAL OF GASTROENTEROLOGY   111 ( 6 )   768 - 768   2016.06( ISSN:0002-9270

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    DOI: 10.1038/ajg.2016.76

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  • Usefulness of PPIs in the Healing of Ulcers After ESD for Early Esophageal Cancer: Comparison Using Propensity Score Matching Reviewed

    Takahashi Yoshiaki, Takeuchi Toshihisa, Kawaguchi Shinpei, Harada Satoshi, Ota Kazuhiro, Edogawa Shoko, Kojima Yuichi, Shiba Masatsugu, Higuchi Kazuhide

    GASTROINTESTINAL ENDOSCOPY   83 ( 5 )   AB586 - AB587   2016.05( ISSN:0016-5107

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  • Mechanisms of NLRP3 inflammasome activation and its role in NSAID-induced enteropathy Reviewed

    Higashimori A., Watanabe T., Nadatani Y., Takeda S., Otani K., Tanigawa T., Yamagami H., Shiba M., Tominaga K., Fujiwara Y., Arakawa T.

    MUCOSAL IMMUNOLOGY   9 ( 3 )   659 - 668   2016.05( ISSN:1933-0219

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    DOI: 10.1038/mi.2015.89

  • Predictive Endoscopic Findings of Positive Vertical Margin in Endoscopic Submucosal Dissection for Submucosal Invasive Colorectal Carcinoma: Towards Expanded Indications for Endoscopic Resection Reviewed

    Kinoshita Yosuke, Fukunaga Shusei, Nagami Yasuaki, Shiba Masatsugu, Tanoue Koujiro, Hayashi Kappei, Sakai Taishi, Maruyama Hirotsugu, Kato Kunihiro, Minamino Hiroaki, Ominami Masaki, Sugimori Satoshi, Tanaka Fumio, Kamata Noriko, Yamagami Hirokazu, Tanigawa Tetsuya, Watanabe Toshio, Tominaga Kazunari, Fujiwara Yasuhiro, Arakawa Tetsuo

    GASTROINTESTINAL ENDOSCOPY   83 ( 5 )   AB364 - AB365   2016.05( ISSN:0016-5107

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  • Randomized Controlled Trial of Sedation: Comparing Propofol With Midazolam in Endoscopic Submucosal Dissection for Esophageal Squamous Cell Carcinoma Reviewed

    Ominami Masaki, Nagami Yasuaki, Shiba Masatsugu, Sakai Taishi, Maruyama Hirotsugu, Kato Kunihiro, Minamino Hiroaki, Fukunaga Shusei, Tanaka Fumio, Sugimori Satoshi, Kamata Noriko, Machida Hirohisa, Yamagami Hirokazu, Tanigawa Tetsuya, Watanabe Toshio, Tominaga Kazunari, Fujiwara Yasuhiro, Arakawa Tetsuo

    GASTROINTESTINAL ENDOSCOPY   83 ( 5 )   AB571 - AB572   2016.05( ISSN:0016-5107

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  • Single Locoregional Triamcinolone Injection Immediately After ESD for Superficial Esophageal Cancer Prevents Stricture Formation: A Propensity Score Matching Analysis Reviewed

    Nagami Yasuaki, Ominami Masaki, Shiba Masatsugu, Sakai Taishi, Minamino Hiroaki, Fukunaga Shusei, Sugimori Satoshi, Tanaka Fumio, Kamata Noriko, Yamagami Hirokazu, Tanigawa Tetsuya, Watanabe Toshio, Tominaga Kazunari, Fujiwara Yasuhiro, Arakawa Tetsuo

    GASTROINTESTINAL ENDOSCOPY   83 ( 5 )   AB583 - AB583   2016.05( ISSN:0016-5107

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  • Effect of Preoperative Biopsy on Colorectal Endoscopic Submucosal Dissection for Laterally Spreading Tumors: Using Propensity Score Matching Reviewed

    Fukunaga Shusei, Nagami Yasuaki, Shiba Masatsugu, Tanoue Koujiro, Hayashi Kappei, Kinoshita Yosuke, Sakai Taishi, Maruyama Hirotsugu, Kato Kunihiro, Minamino Hiroaki, Ominami Masaki, Sugimori Satoshi, Tanaka Fumio, Kamata Noriko, Yamagami Hirokazu, Tanigawa Tetsuya, Watanabe Toshio, Tominaga Kazunari, Fujiwara Yasuhiro, Arakawa Tetsuo

    GASTROINTESTINAL ENDOSCOPY   83 ( 5 )   AB118 - AB118   2016.05( ISSN:0016-5107

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  • Heparin bridging therapy is associated with post-colorectal polypectomy bleeding in patients with interrupted oral anticoagulation therapy Reviewed

    Sakai Taishi, Nagami Yasuaki, Shiba Masatsugu, Hayashi Kappei, Tanoue Koujiro, Kinoshita Yosuke, Maruyama Hirotsugu, Kato Kunihiro, Minamino Hiroaki, Ominami Masaki, Fukunaga Shusei, Tanaka Fumio, Sugimori Satoshi, Kamata Noriko, Yamagami Hirokazu, Tanigawa Tetsuya, Watanabe Toshio, Tominaga Kazunari, Fujiwara Yasuhiro, Arakawa Tetsuo

    GASTROINTESTINAL ENDOSCOPY   83 ( 5 )   AB406 - AB407   2016.05( ISSN:0016-5107

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  • Lithotripsy Is the Risk Factor of Post-Endoscopic Retrograde Cholangiopancreatography (PEP) Using Propensity Score Matching Analysis Reviewed

    Sugimori Satoshi, Shiba Masatsugu, Tanoue Koujiro, Kinoshita Yosuke, Hayashi Kappei, Sakai Taishi, Maruyama Hirotsugu, Minamino Hiroaki, Kato Kunihiro, Ominami Masaki, Fukunaga Shusei, Nagami Yasuaki, Tanaka Fumio, Tanigawa Tetsuya, Watanabe Toshio, Tominaga Kazunari, Fujiwara Yasuhiro, Arakawa Tetsuo

    GASTROINTESTINAL ENDOSCOPY   83 ( 5 )   AB260 - AB260   2016.05( ISSN:0016-5107

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  • Locoregional steroid injection prevents stricture formation after endoscopic submucosal dissection for esophageal cancer: a propensity score matching analysis Reviewed

    Nagami Yasuaki, Shiba Masatsugu, Tominaga Kazunari, Minamino Hiroaki, Ominami Masaki, Fukunaga Shusei, Sugimori Satoshi, Tanigawa Tetsuya, Yamagami Hirokazu, Watanabe Kenji, Watanabe Toshio, Fujiwara Yasuhiro, Arakawa Tetsuo

    SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES   30 ( 4 )   1441 - 1449   2016.04( ISSN:0930-2794

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    DOI: 10.1007/s00464-015-4348-x

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  • Propensity scoreマッチング解析を用いた非ステロイド系抗炎症薬服用関節リウマチ患者における小腸傷害の発症と高年齢との関連性の検討 Reviewed

    谷川 徹也, 渡辺 俊雄, 斯波 将次, 灘谷 祐二, 永見 康明, 杉森 聖司, 山上 博一, 富永 和作, 藤原 靖弘, 荒川 哲男, 小池 達也

    (NPO)日本高齢消化器病学会 日本高齢消化器病学会誌   18 ( 2 )   87 - 93   2016.04( ISSN:1881-0837

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    【背景と目的】非ステロイド系抗炎症薬(NSAIDs)は高率に小腸傷害を誘発する。本研究ではNSAIDs常用関節リウマチ(RA)患者における小腸傷害の発症と高年齢との関連性を、観察的データから無作為比較試験に近い結果を得る統計学的手法であるpropensity score(PS)マッチング解析を用いて検討した。【方法】当科にてカプセル小腸内視鏡検査を施行したNSAIDs常用RA患者95例における小腸粘膜欠損をscoring system(0,normal;1,red spots;2,1 to 4 erosions;3,>4 erosions;and 4,large erosions/ulcers)により評価し各症例を重症粘膜傷害(score 3 or 4)を有する例と有さない(score 0-2)例に郡別した。本研究では65歳以上を高齢者、65歳未満を非高齢者と定義した。飲酒・喫煙歴、消化性潰瘍の既往、NSAIDsの種類(COX非選択的阻害薬vs COX-2優位/選択的阻害薬)・用量、生物学的製剤、サラゾスルファピリジン、酸分泌抑制剤、ビスホスホネート、メトトレキセート、ステロイドの使用の有無を聴取した。PSマッチング解析によりケース・マッチングを行いselection biasの調整を行った。【結果】PSマッチング解析により対象患者95例から高齢者40例および非高齢者40例をマッチング・ペアとして選択した。NSAIDs服用高齢RA患者40例中21例に重症粘膜傷害が観察された。一方、非高齢者群において重症粘膜傷害を有する症例は40例中10例であり、高齢者における重症粘膜傷害有病率は有意に高率であった(p=0.014、OR4.0、95%CI、1.337-11.96)。【結論】NSAIDs服用RA患者において高齢であることは小腸傷害の発生危険因子となることが強く示唆された。(著者抄録)

  • Characteristics of nighttime reflux assessed using multichannel intraluminal impedance pH monitoring and a portable electroencephalograph Reviewed

    Fujiwara Y., Kohata Y., Nakahara K., Tanigawa T., Yamagami H., Shiba M., Watanabe K., Tominaga K., Watanabe T., Arakawa T.

    DISEASES OF THE ESOPHAGUS   29 ( 3 )   278 - 284   2016.04( ISSN:1120-8694

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    DOI: 10.1111/dote.12324

  • Long-Term Benefits of Smoking Cessation on Gastroesophageal Reflux Disease and Health-Related Quality of Life Reviewed

    Kohata Yukie, Fujiwara Yasuhiro, Watanabe Takanori, Kobayashi Masanori, Takemoto Yasuhiko, Kamata Noriko, Yamagami Hirokazu, Tanigawa Tetsuya, Shiba Masatsugu, Watanabe Toshio, Tominaga Kazunari, Shuto Taichi, Arakawa Tetsuo

    PLOS ONE   11 ( 2 )   e0147860   2016.02( ISSN:1932-6203

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    DOI: 10.1371/journal.pone.0147860

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  • Comparison of Risk Factors Between Small Intestinal Ulcerative and Vascular Lesions in Occult Versus Overt Obscure Gastrointestinal Bleeding Reviewed

    Okamoto Junichi, Tominaga Kazunari, Sugimori Satoshi, Kato Kunihiro, Minamino Hiroaki, Ominami Masaki, Fukunaga Shusei, Nagami Yasuaki, Kamata Noriko, Yamagami Hirokazu, Tanigawa Tetsuya, Shiba Masatsugu, Watanabe Toshio, Fujiwara Yasuhiro, Arakawa Tetsuo

    DIGESTIVE DISEASES AND SCIENCES   61 ( 2 )   533 - 541   2016.02( ISSN:0163-2116

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    DOI: 10.1007/s10620-015-3904-5

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  • Reduction of prostaglandin transporter predicts poor prognosis associated with angiogenesis in gastric adenocarcinoma Reviewed

    Takeda Shogo, Tanigawa Tetsuya, Watanabe Toshio, Tatsuwaki Hiroshi, Nadatani Yuji, Otani Koji, Nagami Yasuaki, Tanaka Fumio, Kamata Noriko, Yamagami Hirokazu, Shiba Masatsugu, Tominaga Kazunari, Fujiwara Yasuhiro, Muguruma Kazuya, Ohira Masaichi, Hirakawa Kosei, Arakawa Tetsuo

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   31 ( 2 )   376 - 383   2016.02( ISSN:0815-9319

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    DOI: 10.1111/jgh.13079

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  • Intramural hematoma of the colon caused by double-balloon enteroscopy in a patient with chronic disseminated intravascular coagulation Reviewed

    Nagami Yasuaki, Fujiwara Yasuhiro, Yamamura Masafumi, Shiba Masatsugu, Watanabe Toshio, Tominaga Kazunari, Arakawa Tetsuo

    ENDOSCOPY   48   E105 - E106   2016( ISSN:0013-726X

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    DOI: 10.1055/s-0042-104276

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  • Prediction of Poor Response to Modified Neuroleptanalgesia with Midazolam for Endoscopic Submucosal Dissection for Esophageal Squamous Cell Carcinoma Reviewed

    Ominami Masaki, Nagami Yasuaki, Shiba Masatsugu, Tominaga Kazunari, Maruyama Hirotsugu, Okamoto Junichi, Kato Kunihiro, Minamino Hiroaki, Fukunaga Shusei, Sugimori Satoshi, Yamagami Hirokazu, Tanigawa Tetsuya, Watanabe Toshio, Fujiwara Yasuhiro, Arakawa Tetsuo

    DIGESTION   94 ( 2 )   73 - 81   2016( ISSN:0012-2823

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    DOI: 10.1159/000447666

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  • A novel endoscopic technique for closure of a large esophageal perforation using the clip-and-snare method with the prelooping technique Reviewed

    Nagami Yasuaki, Shiba Masatsugu, Ominami Masaki, Tominaga Kazunari, Watanabe Toshio, Fujiwara Yasuhiro, Arakawa Tetsuo

    ENDOSCOPY   48   E250 - E251   2016( ISSN:0013-726X

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    DOI: 10.1055/s-0042-110488

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  • Characteristics of Sleep Disturbances in Patients with Gastroesophageal Reflux Disease Reviewed

    Iwakura Narika, Fujiwara Yasuhiro, Shiba Masatsugu, Ochi Masahiro, Fukuda Takashi, Tanigawa Tetsuya, Yamagami Hirokazu, Tominaga Kazunari, Watanabe Toshio, Arakawa Tetsuo

    一般社団法人 日本内科学会 INTERNAL MEDICINE   55 ( 12 )   1511 - 1517   2016( ISSN:0918-2918

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    <b>Objective </b>Gastroesophageal reflux disease (GERD) is strongly associated with sleep disturbances; however, the detailed differences in the characteristics of sleep disturbances between GERD and non-GERD patients are unknown. The aim of the present study was to analyze the clinical characteristics as well as health-related quality of life in GERD and non-GERD patients with sleep disturbances. <b>Methods </b>Three hundred and fifty patients, including 124 patients with GERD and 226 patients without GERD, completed a self-administered questionnaire that evaluated clinical information. The Pittsburg Sleep Quality Index (PSQI), Hospital Anxiety and Depression Scale (HADS), Insomnia Severity Index (ISI), Epworth Sleepiness Scale (ESS) and 8-item Short-Form Health Survey (SF-8) were also used. Sleep disturbance was considered to be present if the PSQI was >5.5. <b>Results </b>The prevalence of sleep disturbances was significantly higher in the GERD patients (66/124, 53.9%) than in the non-GERD patients (89/226, 39.3%). Depression and anxiety were significantly more common in the subjects with sleep disturbances than in those without sleep disturbances, although there were no differences between the GERD and non-GERD patients. Among the subjects with sleep disturbances, daytime sleepiness was more common in the GERD patients than in the non-GERD patients. The subjects with sleep disturbances had a poorer health-related quality of life. The physical components of quality of life were impaired, particularly in the GERD patients with sleep disturbances. <b>Conclusion </b>GERD patients with sleep disturbances commonly experience daytime sleepiness and an impaired health-related quality of life, especially in terms of physical components.

    DOI: 10.2169/internalmedicine.55.5454

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    CiNii Article

  • Correction: Long-Term Benefits of Smoking Cessation on Gastroesophageal Reflux Disease and Health-Related Quality of Life. Reviewed

    Kohata Y, Fujiwara Y, Watanabe T, Kobayashi M, Takemoto Y, Kamata N, Yamagami H, Tanigawa T, Shiba M, Watanabe T, Tominaga K, Shuto T, Arakawa T

    PloS one   11 ( 3 )   e0150554   2016

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    DOI: 10.1371/journal.pone.0150554

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  • 早期胃癌研究会症例 proton pump inhibitor投与にて治癒したHelicobacter pylori陰性肉芽腫性胃炎の1例 Reviewed

    永見 康明, 富永 和作, 岡本 純一, 大南 雅揮, 福永 周生, 杉森 聖司, 斯波 将次, 渡辺 憲治, 渡辺 俊雄, 藤原 靖弘, 大澤 政彦, 荒川 哲男

    (株)医学書院 胃と腸   50 ( 12 )   1581 - 1589   2015.11( ISSN:0536-2180

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    患者は59歳,女性.心窩部不快感を主訴に上部消化管内視鏡検査を受けたところ,胃体中部大彎に40mm大の急峻な立ち上がりの辺縁隆起を伴う潰瘍性病変を認め,悪性リンパ腫が疑われた.潰瘍辺縁からの生検組織には非乾酪性類上皮細胞肉芽腫が多数認められた.全身検索を行ったが,肺や眼などにはサルコイドーシスを疑う所見を認めず,結核,梅毒,Crohn病の所見も認めなかった.以上から特発性肉芽腫性胃炎と診断したが,Helicobacter pyloriは陰性であった.前医より開始されたPPIの投与のみで病変は治癒,瘢痕化し,病理組織学的にも肉芽腫は消退した.(著者抄録)

  • 原発性早期診断例の治療奏効(Successful Treatment of Early-Diagnosed Primary Phlegmonous Gastritis) Reviewed

    Kato Kunihiro, Tominaga Kazunari, Sugimori Satoshi, Nagami Yasuaki, Kamata Noriko, Yamagami Hirokazu, Tanigawa Tetsuya, Shiba Masatsugu, Watanabe Toshio, Fujiwara Yasuhiro, Arakawa Tetsuo

    (一社)日本内科学会 Internal Medicine   54 ( 22 )   2863 - 2866   2015.11( ISSN:0918-2918

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    症例は64歳男性で、慢性膵炎と2型糖尿病の病歴があり、26歳時に十二指腸潰瘍穿孔の治療のためビルロートII胃切除による胃亜全摘術の施行歴があった。重度心窩部痛と悪心のため他院に入院となり、慢性膵炎の急性増悪と診断され、抗生物質を処方されたが、4日後に心窩部痛と悪心が再発した。コントラスト腹部CTで胃壁の肥厚と壁内に低吸収域が認められ、当院に紹介来院となった。腹部CTで、膵仮性嚢胞から胃壁へと拡大する膵外炎症が認められた。食道胃十二指腸内視鏡検査では、周囲を浮腫性粘膜と膿様粘液が取り囲む巨大な胃潰瘍が認められた。病変部の生検組織の培養により、胃蜂窩織炎と診断した。プロトンポンプ阻害剤と抗生物質による保存療法を行ったところ、改善した。

  • Inhibitory Effect of Rebamipide on Indomethacin-Induced Experimental Small Intestinal Injury and Exacerbation of the Injury Induced by Proton Pump Inhibitor: Possible Involvement of Modulation of Intestinal Microbiota by Rebamipide Reviewed

    Tanigawa Tetsuya, Watanabe Toshio, Takeda Shogo, Higashimori Akira, Shimada Sunao, Nadatani Yuji, Otani Koji, Tanaka Fumio, Kamata Noriko, Nagami Yasuaki, Yamagami Hirokazu, Shiba Masatsugu, Tominaga Kazunari, Fujiwara Yasuhiro, Arakawa Tetsuo

    DIGESTIVE DISEASES AND SCIENCES   60 ( 9 )   2562 - 2562   2015.09( ISSN:0163-2116

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  • Rebamipide Alters the Esophageal Microbiome and Reduces the Incidence of Barrett's Esophagus in a Rat Model Reviewed

    Kohata Yukie, Nakahara Kenichi, Tanigawa Tetsuya, Yamagami Hirokazu, Shiba Masatsugu, Watanabe Toshio, Tominaga Kazunari, Fujiwara Yasuhiro, Arakawa Tetsuo

    DIGESTIVE DISEASES AND SCIENCES   60 ( 9 )   2654 - 2661   2015.09( ISSN:0163-2116

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    DOI: 10.1007/s10620-015-3662-4

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  • インフルエンザワクチン追加投与は、免疫抑制剤治療を受けている成人炎症性腸疾患患者の免疫反応を改善しない 無作為化試験(Booster influenza vaccination does not improve immune response in adult inflammatory bowel disease patients treated with immunosuppressives: a randomized controlled trial) Reviewed

    Matsumoto Hiroko, Ohfuji Satoko, Watanabe Kenji, Yamagami Hirokazu, Fukushima Wakaba, Maeda Kazuhiro, Kamata Noriko, Sogawa Mitsue, Shiba Masatsugu, Tanigawa Tetsuya, Tominaga Kazunari, Watanabe Toshio, Fujiwara Yasuhiro, Hirota Yoshio, Arakawa Tetsuo

    シュプリンガー・ジャパン(株) Journal of Gastroenterology   50 ( 8 )   876 - 886   2015.08( ISSN:0944-1174

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    免疫調整剤ないし抗TNF-α製剤を投与されている成人炎症性腸疾患(IBD)患者および健常者に三価インフルエンザワクチンを接種し、無作為に1回接種群と2回接種群に振り分けた。ワクチン接種前、接種3週間後、2回投与群では第2回投与3週間後、およびインフルエンザ流行期後に血液を採取してインフルエンザウイルスに対する抗体価を測定した。IBD患者78例と健常人11名が本試験に参加し、無作為化割り振りを受けた。29例は免疫調節剤を投与されていた。21例は抗TNF-α製剤を投与されており、28例は両方の投与を受けていた。免疫反応因子に関して、1回投与群の投与3週間後の結果と、2回投与群の第2回投与3週間後の結果に、有意差は認められなかった。ワクチン接種前のタイターが高いことと、接種後のH1N1株に対する血清防御率が十分得られることとの間に有意な関連が認められた。

  • Booster influenza vaccination does not improve immune response in adult inflammatory bowel disease patients treated with immunosuppressives: a randomized controlled trial Reviewed

    Matsumoto Hiroko, Ohfuji Satoko, Watanabe Kenji, Yamagami Hirokazu, Fukushima Wakaba, Maeda Kazuhiro, Kamata Noriko, Sogawa Mitsue, Shiba Masatsugu, Tanigawa Tetsuya, Tominaga Kazunari, Watanabe Toshio, Fujiwara Yasuhiro, Hirota Yoshio, Arakawa Tetsuo

    JOURNAL OF GASTROENTEROLOGY   50 ( 8 )   876 - 886   2015.08( ISSN:0944-1174

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    DOI: 10.1007/s00535-015-1042-7

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  • プロトンポンプ阻害剤抵抗性の非びらん性胃食道逆流症患者における、内視鏡所見と多チャンネル腔内インピーダンス・pHモニタリングを用いた機能評価との関連性(Associations between endoscopic findings and functional assessment via multichannel intraluminal impedance-pH monitoring in patients with non-erosive reflux disease refractory to proton-pump inhibitors) Reviewed

    Fujiwara Yasuhiro, Kohata Yukie, Tanigawa Tetsuya, Yamagami Hirokazu, Shiba Masatsugu, Tominaga Kazunari, Watanabe Toshio, Arakawa Tetsuo

    シュプリンガー・ジャパン(株) Esophagus   12 ( 3 )   244 - 250   2015.07( ISSN:1612-9059

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    プロトンポンプ阻害剤(PPI)抵抗性の非びらん性胃食道逆流症(NERD)患者について、多チャンネル腔内インピーダンス・pH(MII-pH)モニタリングによる機能評価に基づき、内視鏡所見の有病率を後向きに検査した。PPI抵抗性NERD患者34例(男性17例、女性17例、平均57.8歳)を、MII-pHモニタリングの結果から、呑酸8例、非呑酸17例、機能性胸やけ9例に分類した。内視鏡により、白濁、紅斑、食道胃接合部における良好な血管網パターンの消失、食道中部における血管網の過形成、ヘルニア、フラップ弁グレード、萎縮性胃炎といった微小変化を評価した。群間で微小変化の有病率に違いはなかったが、全食道の外周に白濁を示した症例はいずれも非呑酸であった。食道裂孔ヘルニアと異常フラップ弁の有病率は3群で違いがなかったが、萎縮性胃炎の存在は呑酸、非呑酸よりも機能性胸やけで有意に高かった。食道中部における血管網の過形成の有病率はproximal migrationのある患者の方がない患者よりも有意に高かった。以上から、内視鏡所見とMII-pHモニタリングによる機能的評価には関連があることが示された。

  • Associations between endoscopic findings and functional assessment via multichannel intraluminal impedance-pH monitoring in patients with non-erosive reflux disease refractory to proton-pump inhibitors Reviewed

    Fujiwara Yasuhiro, Kohata Yukie, Tanigawa Tetsuya, Yamagami Hirokazu, Shiba Masatsugu, Tominaga Kazunari, Watanabe Toshio, Arakawa Tetsuo

    ESOPHAGUS   12 ( 3 )   244 - 250   2015.07( ISSN:1612-9059

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    DOI: 10.1007/s10388-014-0480-2

  • The Five-Year Survival Rate After Endoscopic Submucosal Dissection for Superficial Esophageal Squamous Cell Carcinoma Reviewed

    Ominami Masaki, Nagami Yasuaki, Shiba Masatsugu, Sakai Taishi, Maruyama Hirotsugu, Okamoto Junichi, Kato Kunihiro, Minamino Hiroaki, Fukunaga Shusei, Tanaka Fumio, Sugimori Satoshi, Kamata Noriko, Yamagami Hirokazu, Tanigawa Tetsuya, Watanabe Toshio, Tominaga Kazunari, Fujiwara Yasuhiro, Arakawa Tetsuo

    GASTROINTESTINAL ENDOSCOPY   81 ( 5 )   AB516 - AB517   2015.05( ISSN:0016-5107

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  • NSAIDs起因性小腸傷害におけるインフラマソームの活性化機構 Reviewed

    大谷 恒史, 渡辺 俊雄, 東森 啓, 武田 翔伍, 灘谷 祐二, 田中 史生, 鎌田 紀子, 山上 博一, 谷川 徹也, 斯波 将次, 富永 和作, 藤原 靖弘, 荒川 哲男

    (一社)日本潰瘍学会 潰瘍   42   67 - 71   2015.05( ISSN:2189-7956

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    自然免疫による生体防御機構は、パターン認識受容体(PRR)が、感染に伴う病原体関連分子パターンや細胞傷害に伴う傷害関連分子パターンを認識することで発動し、主なPRRとしてtoll-like receptorやNod様受容体(NLR)などが知られている。NLRは細胞内に存在し、危険シグナルによって活性化されるとインフラマソームという巨大分子複合体を形成して炎症を誘導する。また、インフラマソームはNSAIDs起因性小腸傷害の発症にも深く関与していることが推測されている。そこで今回、同小腸傷害におけるインフラマソームの活性化機構についてマウスモデルを用いて検討した。その結果、NSAIDs起因性小腸傷害の病態において、NLRP3インフラマソーム内で活性化されたcaspase-1により誘導された成熟型IL-1βが重要な役割を果たしていることが示唆された。

  • Safety and Long-Term Survival of Endoscopic Submucosal Dissection for Superficial Esophageal Squamous Cell Carcinoma in Elderly Patients Reviewed

    Nagami Yasuaki, Ominami Masaki, Shiba Masatsugu, Sakai Taishi, Maruyama Hirotsugu, Okamoto Junichi, Kato Kunihiro, Minamino Hiroaki, Fukunaga Shusei, Tanaka Fumio, Sugimori Satoshi, Kamata Noriko, Yamagami Hirokazu, Tanigawa Tetsuya, Watanabe Toshio, Tominaga Kazunari, Fujiwara Yasuhiro, Arakawa Tetsuo

    GASTROINTESTINAL ENDOSCOPY   81 ( 5 )   AB516 - AB516   2015.05( ISSN:0016-5107

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  • Efficacy of Concomitant Elemental Diet Therapy in Scheduled Infliximab Therapy in Patients with Crohn's Disease to Prevent Loss of Response Reviewed

    Kamata Noriko, Oshitani Nobuhide, Watanabe Kenji, Watanabe Kimihiko, Hosomi Shuhei, Noguchi Atsushi, Yukawa Tomomi, Yamagami Hirokazu, Shiba Matsatsugu, Tanigawa Tetsuya, Watanabe Toshio, Tominaga Kazunari, Fujiwara Yasuhiro, Arakawa Tetsuo

    DIGESTIVE DISEASES AND SCIENCES   60 ( 5 )   1382 - 1388   2015.05( ISSN:0163-2116

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    DOI: 10.1007/s10620-014-3493-8

  • Evaluation of Clinical Factors Associated With Positive Capsule Endoscopy Findings in Patients With Obscure Gastrointestinal Bleeding: a Single-Center Analysis Reviewed

    Shimada Sunao, Watanabe Toshio, Nadatani Yuji, Takeda Shogo, Otani Koji, Tanaka Fumio, Kamata Noriko, Yamagami Hirokazu, Tanigawa Tetsuya, Shiba Masatsugu, Tominaga Kazunari, Fujiwara Yasuhiro, Arakawa Tetsuo

    GASTROINTESTINAL ENDOSCOPY   81 ( 5 )   AB478 - AB479   2015.05( ISSN:0016-5107

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  • Long-Term Prognosis of Expanded-Indication Lesions of Differentiated-Type Early Gastric Cancer: a Comparative Analysis Using Propensity Score Matching Between Endoscopic Submucosal Dissection and Surgery Reviewed

    Fukunaga Shusei, Nagami Yasuaki, Shiba Masatsugu, Tanaka Hiroaki, Muguruma Kazuya, Minamino Hiroaki, Ominami Masaki, Sugimori Satoshi, Tanigawa Tetsuya, Yamagami Hirokazu, Watanabe Toshio, Tominaga Kazunari, Fujiwara Yasuhiro, Ohira Masaichi, Hirakawa Kosei, Arakawa Tetsuo

    GASTROINTESTINAL ENDOSCOPY   81 ( 5 )   AB197 - AB197   2015.05( ISSN:0016-5107

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  • A Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial of High-Dose Rebamipide Treatment for Low-Dose Aspirin-Induced Moderate-to-Severe Small Intestinal Damage Reviewed

    Watanabe Toshio, Takeuchi Toshihisa, Handa Osamu, Sakata Yasuhisa, Tanigawa Tetsuya, Shiba Masatsugu, Naito Yuji, Higuchi Kazuhide, Fujimoto Kazuma, Yoshikawa Toshikazu, Arakawa Tetsuo

    PLOS ONE   10 ( 4 )   e0122330   2015.04( ISSN:1932-6203

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    DOI: 10.1371/journal.pone.0122330

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  • Basophil infiltration in eosinophilic oesophagitis and proton pump inhibitor-responsive oesophageal eosinophilia Reviewed

    Iwakura N., Fujiwara Y., Tanaka F., Tanigawa T., Yamagami H., Shiba M., Tominaga K., Watanabe T., Iijima K., Koike T., Walls A. F., Arakawa T.

    ALIMENTARY PHARMACOLOGY & THERAPEUTICS   41 ( 8 )   776 - 784   2015.04( ISSN:0269-2813

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    DOI: 10.1111/apt.13141

  • Usefulness of baseline impedance in patients with proton pump inhibitor-refractory nonerosive reflux disease Reviewed

    Kohata Yukie, Fujiwara Yasuhiro, Yamagami Hirokazu, Tanigawa Tetsuya, Shiba Masatsugu, Watanabe Kenji, Watanabe Toshio, Tominaga Kazunari, Arakawa Tetsuo

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   30   36 - 40   2015.03( ISSN:0815-9319

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    DOI: 10.1111/jgh.12743

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  • 【消化器疾患の病態生理】逆流性食道炎と睡眠障害の関連についての検討 Reviewed

    中原 憲一, 藤原 靖弘, 山上 博一, 谷川 徹也, 斯波 将次, 富永 和作, 渡辺 俊雄, 裏出 良博, 荒川 哲男

    (株)ライフ・サイエンス Progress in Medicine   35 ( 3 )   445 - 449   2015.03( ISSN:0287-3648

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    逆流性食道炎と睡眠障害の関連について検討した。ラットの前胃を結紮し、幽門部近傍の十二指腸をネラトンカテーテルで被覆することにより、ラット慢性酸逆流性食道炎モデルを作成した。逆流性食道炎群のラットでは、いずれも肉眼的に食道中下部に白色調粘膜肥厚、潰瘍の形成を認め、組織学的に基底細胞過形成、乳頭延長、炎症細胞浸潤を伴う粘膜肥厚が認められた。明期におけるwake時間は、逆流性食道炎群で34%の有意な増加が認められた。同時にNREM睡眠時間は逆流性食道炎群において有意な減少を認めた。逆流性食道炎群では、正常の睡眠パターンが崩壊され、睡眠断片化が起こっていることが判明した。胃酸分泌を十分抑制する用量のオメプラゾール投与により、逆流性食道炎による睡眠障害が有意に改善し、PPI投与中止後に再度睡眠障害を認められたことから、酸の逆流が直接睡眠障害を引き起こすことが判明した。

  • アクチグラフィーに基づいて判定した胃食道逆流症患者における睡眠に対するエソメプラゾールの効果(Effects of Esomeprazole on Sleep in Patients with Gastroesophageal Reflux Disease as Assessed on Actigraphy) Reviewed

    Hiramoto Keiko, Fujiwara Yasuhiro, Ochi Masahiro, Okuyama Masatsugu, Tanigawa Tetsuya, Yamagami Hirokazu, Shiba Masatsugu, Watanabe Kenji, Watanabe Toshio, Tominaga Kazunari, Arakawa Tetsuo

    (一社)日本内科学会 Internal Medicine   54 ( 6 )   559 - 565   2015.03( ISSN:0918-2918

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    胃食道逆流症(GERD)に対するエソメプラゾール(EP)の効果を検討した。13名のGERD患者にEPを1日20mg、2週間投与した。投与3日前から試験終了までアクチグラフを装着させ、睡眠パラメータを解析した。GERD症状頻度スケール(FSSG)、Pittburg睡眠の質指標(PSQI)とEpworth睡眠スケール(ESS)について質問票調査を行った。EP治療はESSスコアと共に、逆流と運動障害スコアを含む総FSSGスコアを有意に低下させた。しかしPSQIスコアには影響がなかった。治療2週間後に、EPはすべての睡眠パラメータは改善しないが、覚醒時間(平均47.5〜36.0分)と睡眠潜時時間(平均19.5〜9.9分)を有意に短縮し、睡眠時間の割合(平均89.1〜91.6%)を増加させた。以上より、EPは日本人のGERD患者の睡眠のパラメータを有意に改善すると考えられた。

  • Clinical impact of ultrathin colonoscopy for Crohn's disease patients with strictures Reviewed

    Morimoto Kenichi, Watanabe Kenji, Noguchi Atsushi, Miyazaki Takako, Nagami Yasuaki, Sugimori Satoshi, Kamata Noriko, Sogawa Mitsue, Tanigawa Tetsuya, Yamagami Hirokazu, Shiba Masatsugu, Tominaga Kazunari, Watanabe Toshio, Fujiwara Yasuhiro, Arakawa Tetsuo

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   30   66 - 70   2015.03( ISSN:0815-9319

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    DOI: 10.1111/jgh.12739

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  • Association between chronic use of proton pump inhibitors and small- intestinal bacterial overgrowth assessed using lactulose hydrogen breath tests. Reviewed

    Fujiwara Y, Watanabe T, Muraki M, Yamagami H, Tanigawa T, Shiba M, Tominaga K, Arakawa T

    Hepato-gastroenterology   62 ( 138 )   268 - 72   2015.03( ISSN:0172-6390

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  • Tumor Necrosis Factor alpha Decreases Glucagon-Like Peptide-2 Expression by Up-Regulating G-Protein-Coupled Receptor 120 in Crohn Disease Reviewed

    Tsukahara Takuya, Watanabe Kenji, Watanabe Toshio, Yamagami Hirokazu, Sogawa Mitsue, Tanigawa Tetsuya, Shiba Masatsugu, Tominaga Kazunari, Fujiwara Yasuhiro, Maeda Kiyoshi, Hirakawa Kosei, Arakawa Tetsuo

    AMERICAN JOURNAL OF PATHOLOGY   185 ( 1 )   185 - 196   2015.01( ISSN:0002-9440

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    DOI: 10.1016/j.ajpath.2014.09.010

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  • Successful Treatment of Early-Diagnosed Primary Phlegmonous Gastritis Reviewed

    Kato Kunihiro, Tominaga Kazunari, Sugimori Satoshi, Nagami Yasuaki, Kamata Noriko, Yamagami Hirokazu, Tanigawa Tetsuya, Shiba Masatsugu, Watanabe Toshio, Fujiwara Yasuhiro, Arakawa Tetsuo

    一般社団法人 日本内科学会 INTERNAL MEDICINE   54 ( 22 )   2863 - 2866   2015( ISSN:0918-2918

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    A 64-year-old man presented with epigastralgia and nausea after an acute exacerbation of chronic pancreatitis. Abdominal computed tomography revealed remarkable thickening of the gastric wall and intramural hypodense areas. Esophagogastroduodenoscopy showed a large gastric ulcer surrounded by an edematous mucosa and mucopus. The results of a culture from a biopsy of the lesion indicated phlegmonous gastritis. The patient was successfully treated with an antibiotic without gastrectomy.<br>

    DOI: 10.2169/internalmedicine.54.4257

    PubMed

    CiNii Article

  • Gastric Glial Cells as Responses to Early Life Stress (Maternal Separation) and Acute Stress in Adulthood in Rats Reviewed

    Tominaga Kazunari, Fujikawa Yoshiko, Tanaka Fumio, Sogawa Mitsue, Yamagami Hirokazu, Tanigawa Tetsuya, Shiba Masatsugu, Watanabe Kenji, Watanabe Toshio, Fujiwara Yasuhiro, Arakawa Tetsuo

    DIGESTION   91 ( 1 )   87 - 87   2015( ISSN:0012-2823

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  • Rectal biopsy, rather than ileal, is appropriate to confirm the diagnosis of early gastrointestinal graft-versus-host disease Reviewed

    Minamino Hiroaki, Machida Hirohisa, Tominaga Kazunari, Morimoto Kenichi, Ominami Masaki, Fukunaga Shusei, Hosomi Shuhei, Hayashi Yoshiki, Nagami Yasuaki, Sugimori Satoshi, Kamata Noriko, Shiba Masatsugu, Nakamae Hirohisa, Yamagami Hirokazu, Tanigawa Tetsuya, Watanabe Toshio, Fujiwara Yasuhiro, Ohsawa Masahiko, Hino Masayuki, Arakawa Tetsuo

    SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY   50 ( 11 )   1428 - 1434   2015( ISSN:0036-5521

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    DOI: 10.3109/00365521.2015.1054421

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  • Association between Chronic Use of Proton Pump Inhibitors and Small-Intestinal Bacterial Overgrowth Assessed using Lactulose Hydrogen Breath Tests Reviewed

    Fujiwara Yasuhiro, Watanabe Toshio, Muraki Motoko, Yamagami Hirokazu, Tanigawa Tetsuya, Shiba Masatsugu, Tominaga Kazunari, Arakawa Tetsuo

    HEPATO-GASTROENTEROLOGY   62 ( 138 )   268 - 272   2015( ISSN:0172-6390

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    DOI: 10.5754/hge14878

  • Effects of Esomeprazole on Sleep in Patients with Gastroesophageal Reflux Disease as Assessed on Actigraphy Reviewed

    Hiramoto Keiko, Fujiwara Yasuhiro, Ochi Masahiro, Okuyama Masatsugu, Tanigawa Tetsuya, Yamagami Hirokazu, Shiba Masatsugu, Watanabe Kenji, Watanabe Toshio, Tominaga Kazunari, Arakawa Tetsuo

    一般社団法人 日本内科学会 INTERNAL MEDICINE   54 ( 6 )   559 - 565   2015( ISSN:0918-2918

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    <b>Objective</b> Gastroesophageal reflux disease (GERD) is strongly associated with sleep disturbances. Although treatment with proton pump inhibitors (PPIs) helps to improve GERD symptoms and subjective sleep parameters, the effects of PPI therapy on objective sleep parameters are conflicting. The aim of this study was to examine the effects of esomeprazole treatment on GERD symptoms and sleep parameters assessed using actigraphs and questionnaires.<br> <b>Methods</b> Thirteen patients with GERD received 20 mg of esomeprazole once daily for two weeks. The patients wore actigraphs from three days before the initiation of PPI treatment to the end of therapy. They were also asked to answer the following self-reported questionnaires: Frequency Scale for the Symptoms of GERD (FSSG), Pittsburg Sleep Quality Index (PSQI) and Epworth Sleepiness Scale (ESS). Objective sleep parameters were evaluated using actigraphy.<br> <b>Results</b> Treatment with esomeprazole significantly decreased the total FSSG score, including the scores for reflux and dysmotility, as well as the ESS score, although it had no effect on the PSQI score. After the second week of treatment, esomeprazole significantly decreased the wake time (from 47.5&plusmn;39.6 min to 36.0&plusmn;27.1 min) and sleep latency period (from 19.5&plusmn;19.8 min to 9.9&plusmn;10.2 min) and increased the percentage of sleep time (from 89.1&plusmn;8.8% to 91.9&plusmn;6.3%); however, improvements were not noted in all objective parameters.<br> <b>Conclusion</b> Esomeprazole treatment significantly improves various objective sleep parameters in Japanese patients with GERD. Further placebo-controlled randomized trials are needed to obtain detailed results.<br>

    DOI: 10.2169/internalmedicine.54.3718

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    CiNii Article

  • Endoscopic closure of gastrocutaneous leakage with polyglycolic acid sheets Reviewed

    Nagami Yasuaki, Shiba Masatsugu, Tominaga Kazunari, Yamazoe Sadaaki, Amano Ryosuke, Fujiwara Yasuhiro, Arakawa Tetsuo

    ENDOSCOPY   47   E455 - E456   2015( ISSN:0013-726X

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    DOI: 10.1055/s-0034-1392792

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  • バルーン小腸内視鏡検査で診断された小腸原発粘膜関連リンパ組織リンパ腫(Primary Small Intestinal Mucosa-associated Lymphoid Tissue Lymphoma Diagnosed by Balloon-assisted Enteroscopy) Reviewed

    Nadatani Yuji, Tanigawa Tetsuya, Fukunaga Shusei, Kinoshita Yosuke, Ominami Masaki, Obayashi Tomoko, Morimoto Kenichi, Sogawa Mitsue, Yamagami Hirokazu, Shiba Masatsugu, Watanabe Kenji, Watanabe Toshio, Tominaga Kazunari, Fujiwara Yasuhiro, Arakawa Tetsuo

    (一社)日本内科学会 Internal Medicine   53 ( 23 )   2671 - 2674   2014.12( ISSN:0918-2918

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    症例は78歳女性で、2011年6月に貧血、2012年2月に下血のため近医に入院したが、食道胃十二指腸内視鏡検査と結腸鏡検査で出血源が特定できず、精査のため当院に紹介となった。身体所見で重度貧血と下肢の浮腫がみられた。経口ダブルバルーン内視鏡検査(DBE)を施行したところ、空腸中部から約20cm上に伸びる凝塊を覆う多発性潰瘍性病変が検出された。組織病理学的検査の所見から、小腸の粘膜関連リンパ組織(MALT)リンパ腫と診断した。2回目のDBE時に潰瘍性病変の一つで小腸穿孔が起こり、緊急小腸部分切除術を施行した。病変の外科的切除に成功し、23日後に退院となった。経過観察時点でMALTリンパ腫の再発は観察されなかった。

  • Toll-Like Receptor 2 Mediates Ischemia-Reperfusion Injury of the Small Intestine in Adult Mice Reviewed

    Watanabe Toshio, Tanigawa Tetsuya, Kobata Atsushi, Takeda Shogo, Nadatani Yuji, Otani Koji, Yamagami Hirokazu, Shiba Masatsugu, Tominaga Kazunari, Fujiwara Yasuhiro, Arakawa Tetsuo

    PLOS ONE   9 ( 10 )   e110441   2014.10( ISSN:1932-6203

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    DOI: 10.1371/journal.pone.0110441

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  • Acid Reflux Directly Causes Sleep Disturbances in Rat with Chronic Esophagitis Reviewed

    Nakahara Kenichi, Fujiwara Yasuhiro, Tsukahara Takuya, Yamagami Hirokazu, Tanigawa Tetsuya, Shiba Masatsugu, Tominaga Kazunari, Watanabe Toshio, Urade Yoshihiro, Arakawa Tetsuo

    PLOS ONE   9 ( 9 )   e106969   2014.09( ISSN:1932-6203

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  • 【高齢化社会におけるNSAIDs消化管障害】Propensity scoreマッチング解析を用いた非ステロイド系抗炎症薬服用関節リウマチ患者における小腸傷害の発症と高年齢との関連性の検討 Reviewed

    谷川 徹也, 渡辺 俊雄, 斯波 将次, 灘谷 祐二, 永見 康明, 杉森 聖司, 山上 博一, 渡邊 憲治, 富永 和作, 藤原 靖弘, 荒川 哲男, 小池 達也

    (有)科学評論社 消化器内科   59 ( 2 )   131 - 135   2014.08( ISSN:1884-2895

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    2008年1月〜2011年12月に整形外科通院中の関節リウマチ(RA)患者中、非ステロイド抗炎症薬(NSAIDs)を3ヵ月以上、毎日服用している95例を対象に、propensity scoreマッチング(PSM)解析を用い、NSAIDs常用RA患者における小腸傷害の発症と高年齢の関連性について検討した。嚥下障害を有しカプセル小腸内視鏡を嚥下できない者、妊娠中、腹部手術既往、心血管系・呼吸器系・脳神経系に重篤合併を除外し、65歳以上高齢者群55例、65歳未満非高齢者群40例に分けた。PSMにより非高齢者40例、高齢者40例がマッチングペアとして選択された。PSM後、非高齢者40例中、重度障害を有する症例は10例(25%)、高齢者40例中、重度障害を有する症例は21例(53%)で高齢者で重度障害例が多かった。PSM前の高齢のオッズ比は3.96で性別、消化器潰瘍既往歴、COX-2選択的阻害薬使用、抗TNF-α抗体製剤使用、副腎皮質ステロイド使用、酸分泌抑制剤使用により補正したところ、高齢者のオッズ比は3.87であった。PSM後の高齢者のオッズ比は3.32、補正後は3.50であった。

  • 早期胃癌研究会症例 内視鏡的治療を施行した胃I型カルチノイドの1例 Reviewed

    福永 周生, 町田 浩久, 上村 理沙, 永見 康明, 杉森 聖司, 十河 光栄, 谷川 徹也, 斯波 将次, 渡辺 憲治, 渡辺 俊雄, 富永 和作, 藤原 靖弘, 荒川 哲男

    (株)医学書院 胃と腸   49 ( 8 )   1223 - 1231   2014.07( ISSN:0536-2180

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    患者は80歳代,女性.近医にて貧血の精査目的で受診した上部消化管内視鏡検査で,胃体中部小彎に10mm大の立ち上がり明瞭で扁平な隆起性病変を認めた.インジゴカルミン色素撒布観察では,表面に不整な陥凹や潰瘍形成を認めなかった.NBI併用拡大内視鏡観察では,拡張した血管の末梢で細かいnetworkを形成した異常血管を認めた.また,胃体部優位の胃粘膜萎縮を認め,抗胃壁細胞抗体と抗内因子抗体が陽性であった.以上から,I型カルチノイドと診断した.超音波内視鏡検査で,腫瘤は第2層に限局しており,ESDを施行した.クロモグラニンA陽性の腫瘍細胞は,粘膜内に限局して横方向に伸展し,脈管侵襲を認めず,断端陰性であった.非典型的な形態のI型カルチノイドに対して,詳細な内視鏡観察の後にESDを施行した症例を経験したので報告する.(著者抄録)

  • Usefulness of Non-Magnifying Narrow-Band Imaging in Screening of Early Esophageal Squamous Cell Carcinoma: A Prospective Comparative Study Using Propensity Score Matching Reviewed

    Nagami Yasuaki, Tominaga Kazunari, Machida Hirohisa, Nakatani Masami, Kameda Natsuhiko, Sugimori Satoshi, Okazaki Hirotoshi, Tanigawa Tetsuya, Yamagami Hirokazu, Kubo Naoshi, Shiba Masatsugu, Watanabe Kenji, Watanabe Toshio, Iguchi Hiroyoshi, Fujiwara Yasuhiro, Ohira Masaichi, Hirakawa Kosei, Arakawa Tetsuo

    AMERICAN JOURNAL OF GASTROENTEROLOGY   109 ( 6 )   845 - 854   2014.06( ISSN:0002-9270

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    DOI: 10.1038/ajg.2014.94

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  • [Rome III classification and characteristics of Japanese patients with functional dyspepsia]. Reviewed

    Tominaga K, Fujikawa Y, Tanaka F, Tanigawa T, Shiba M, Watanabe T, Fujiwara Y, Arakawa T

    Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology   111 ( 6 )   1079 - 87   2014.06( ISSN:0446-6586

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  • レバミピドの小腸内フローラ調節作用 Reviewed

    谷川 徹也, 渡辺 俊雄, 東森 啓, 武田 翔伍, 灘谷 祐二, 大谷 恒史, 山上 博一, 斯波 将次, 渡辺 憲治, 富永 和作, 藤原 靖弘, 荒川 哲男

    (一社)日本潰瘍学会 潰瘍   41   10 - 13   2014.05( ISSN:2189-7956

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    マウスにレバミピドあるいはオメプラゾールあるいは両剤を1週間連続経口投与後にインドメタシンを経口投与し、インドメンタシン誘発小腸傷害およびプロトンポンプ阻害薬(PPI)の増悪作用に対するレバミピドの抑制効果を検討した。また、ドナー側マウスにレバミピドを1週間連続投与後、採取した小腸内容物をレシピエントマウスに単回経口投与し(フローラ移植)、5日後にインドメタシンを投与して小腸傷害を検討した。レバミピドはインドメタシン誘発小腸傷害およびPPIによるインドメタシン誘発小腸傷害増悪作用を抑制した。また、レバミピド投与マウスのフローラを移植されたマウスではインドメタシン誘発小腸傷害の程度は有意に軽微であった。レバミピドは小腸組織においてα-defensin 5のmRNAおよび蛋白発現レベルを増強したことから、α-defensin 5を介して小腸内フローラを調節しインドメタシン誘発小腸傷害を抑制する可能性があると考えられた。

  • 小腸潰瘍性病変と起因薬剤との関連性 OGIB症例からの検討 Reviewed

    岡本 純一, 富永 和作, 丸山 紘嗣, 加藤 邦洋, 大南 雅揮, 福永 周生, 永見 康明, 杉森 聖司, 谷川 徹也, 山上 博一, 斯波 将次, 渡辺 憲治, 渡辺 俊雄, 藤原 靖弘, 荒川 哲男

    (一社)日本潰瘍学会 潰瘍   41   5 - 9   2014.05( ISSN:2189-7956

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    2007年5月〜2012年3月にカプセル内視鏡(CE)もしくはバルーン内視鏡(BAE)を受けた顕性原因不明消化管出血(overt OGIB)症例263例(男110例、女153例、平均年齢65.14歳)を対象に、小腸潰瘍性病変と薬剤を含めた臨床的背景との関連性を後方視的に検討した。多変量解析の結果、小腸潰瘍性病変が診断される関連因子として非ステロイド性抗炎症薬(NSAIDs)が抽出され、オッズ比は3.177であった。overt OGIBを検査前最低ヘモグロビン(Hb)値で3群に分類した場合、最低Hb値が最も低い群(2.6-7.1)と次に低い群(7.2-9.3)ではNSAIDsが関連因子として抽出されたが、高い群(9.4-15.8)ではNSAIDsは関連因子として抽出されなかった。overt OGIB症例において検査前最低Hb値が低いNSAIDs服用者では小腸潰瘍が強く疑われる。

  • 頸椎椎間板ヘルニア患者におけるバイポーラスネアを用いた声帯ポリープの内視鏡的切除(Endoscopic resection of a vocal cord polyp with a bipolar snare in a patient with cervical disc herniation) Reviewed

    Minamino Hiroaki, Nagami Yasuaki, Tominaga Kazunari, Matsushita Naoki, Sugimori Satoshi, Shiba Masatsugu, Watanabe Toshio, Iguchi Hiroyoshi, Fujiwara Yasuhiro, Arakawa Tetsuo

    シュプリンガー・ジャパン(株) Clinical Journal of Gastroenterology   7 ( 2 )   136 - 139   2014.04( ISSN:1865-7257

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    55歳男性。数年前からの嗄声が悪化し、右真声帯に直径10mmを超える声帯ポリープを認めた。逸脱による気道閉塞予防のためポリープを切除する必要があったが、ポリープ径が大きく、頸椎椎間板ヘルニアの症状があったため、標準的な耳鼻咽喉科的手術による切除が難しかった。そのため全身麻酔下でバイポーラ電気焼灼スネアを用いて声帯ポリープの内視鏡的切除を行なった。ポリープ径は11mmで、病理検査にて扁平上皮に覆われた繊維組織、フィブリン、延長血管を認めた。術後24ヵ月経過し、嗄声は無く生体機能は維持された。

  • 抗血小板・抗凝固療法施行患者における上部消化管粘膜傷害とリスク別にみた酸分泌抑制剤および粘膜防御製剤の効果 Reviewed

    谷川 徹也, 渡辺 俊雄, 灘谷 祐二, 山上 博一, 斯波 将次, 渡辺 憲治, 富永 和作, 藤原 靖弘, 荒川 哲男

    (NPO)日本高齢消化器病学会 日本高齢消化器病学会誌   16 ( 2 )   45 - 49   2014.04( ISSN:1881-0837

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    抗血小板・抗凝固療法施行患者における上部消化管粘膜傷害の有病率を調査し、高齢および消化性潰瘍の既往をハイリスク群としてサブグループ解析した。当該患者364例中、低用量アスピリン(LDA)服用者229例のうち粘膜傷害を有する者は62例(27.1%)であり、多変量解析の結果、LDAは粘膜傷害発症の有意な危険因子であった。LDA服用者のうち全体および75歳未満で消化性潰瘍の既往を有しない群(107例)では、酸分泌抑制剤服用群における傷害有病率は非服用群に比し低かったが、75歳以上の群および潰瘍既往を有する群ではLDA起因性上部消化管粘膜傷害に対する酸分泌抑制剤の予防効果は低リスク群に比し小さい可能性が示唆された。(著者抄録)

  • Endoscopic resection of a vocal cord polyp with a bipolar snare in a patient with cervical disc herniation. Reviewed

    Minamino H, Nagami Y, Tominaga K, Matsushita N, Sugimori S, Shiba M, Watanabe T, Iguchi H, Fujiwara Y, Arakawa T

    Clinical journal of gastroenterology   7 ( 2 )   136 - 9   2014.04( ISSN:1865-7257

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    DOI: 10.1007/s12328-014-0469-3

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  • Infliximab and/or immunomodulators inhibit immune responses to trivalent influenza vaccination in adults with inflammatory bowel disease Reviewed

    Hagihara Yoshie, Ohfuji Satoko, Watanabe Kenji, Yamagami Hirokazu, Fukushima Wakaba, Maeda Kazuhiro, Karnata Noriko, Sogawa Mitsue, Shiba Masatsugu, Tanigawa Tetsuya, Tominaga Kazunari, Watanabe Toshio, Fujiwara Yasuhiro, Hirota Yoshio, Arakawa Tetsuo

    JOURNAL OF CROHNS & COLITIS   8 ( 3 )   223 - 233   2014.03( ISSN:1873-9946

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    DOI: 10.1016/j.crohns.2013.08.008

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  • Successful Treatment of Betamethasone Syrup on Autoimmune Esophagitis Reviewed

    Kohata Yukie, Fujiwara Yasuhiro, Kato Kunihiro, Tanaka Fumio, Yamagami Hirokazu, Tanigawa Tetsuya, Shiba Masatsugu, Watanabe Kenji, Watanabe Toshio, Tominaga Kazunari, Tateishi Chiharu, Tsuruta Daisuke, Arakawa Tetsuo

    AMERICAN JOURNAL OF GASTROENTEROLOGY   109 ( 3 )   451 - 453   2014.03( ISSN:0002-9270

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    DOI: 10.1038/ajg.2013.455

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  • プロバイオティクス・腸内細菌と消化器免疫 レバミピドによるインドメサシン誘発小腸傷害の抑制作用 抗菌ペプチドを介した小腸内フローラ調節作用 Reviewed

    谷川 徹也, 渡辺 俊雄, 灘谷 祐二, 大谷 恒史, 十河 光栄, 山上 博一, 斯波 将次, 渡辺 憲治, 富永 和作, 藤原 靖弘, 荒川 哲男

    日本消化器免疫学会 消化器と免疫   ( 50 )   55 - 58   2014.03

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    粘膜防御製剤であるレバミピド(Reb)のインドメタシン(IM)起因性小腸傷害予防効果を腸内フローラの面から検討した。マウスにRebを1週間投与した後にIMを投与したところRebはIM起因性小腸傷害を抑制した。腸内フローラを解析したところ、Rebは小腸内フローラ構成を変化させた。また、Rebは抗菌ペプチドであるα-defensin 5の小腸組織における発現レベルを増強した。以上より、Rebはα-defensin 5を介して小腸内フローラを調節しIM誘発小腸傷害を抑制する可能性が示唆された。(著者抄録)

  • Clinical Efficacy of Endoscopic Submucosal Dissection for Adenocarcinomas of the Esophagogastric Junction. Reviewed

    Nagami Y, Machida H, Shiba M, Obayashi T, Ominami M, Fukunaga S, Sugimori S, Yamagami H, Tanigawa T, Watanabe K, Watanabe T, Tominaga K, Fujiwara Y, Arakawa T

    Endoscopy international open   2 ( 1 )   E15 - 20   2014.03( ISSN:2364-3722

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    DOI: 10.1055/s-0034-1365276

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  • Role of small intestinal bacterial overgrowth in severe small intestinal damage in chronic non-steroidal anti-inflammatory drug users Reviewed

    Muraki Motoko, Fujiwara Yasuhiro, Machida Hirohisa, Okazaki Hirotoshi, Sogawa Mitsue, Yamagami Hirokazu, Tanigawa Tetsuya, Shiba Masatsugu, Watanabe Kenji, Tominaga Kazunari, Watanabe Toshio, Arakawa Tetsuo

    SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY   49 ( 3 )   267 - 273   2014.03( ISSN:0036-5521

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    DOI: 10.3109/00365521.2014.880182

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  • Anti-tumour necrosis factor agents reduce non-steroidal anti-inflammatory drug-induced small bowel injury in rheumatoid arthritis patients Reviewed

    Watanabe Toshio, Tanigawa Tetsuya, Shiba Masatsugu, Nadatani Yuji, Nagami Yasuaki, Sugimori Satoshi, Yamagami Hirokazu, Watanabe Kenji, Tominaga Kazunari, Fujiwara Yasuhiro, Koike Tatsuya, Arakawa Tetsuo

    GUT   63 ( 3 )   409 - 414   2014.03( ISSN:0017-5749

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    DOI: 10.1136/gutjnl-2013-304713

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  • Preventive Effect of Rebamipide of Indomethacin-Induced Small Intestinal Injury: Possible Involvement of Modulation of Bacterial Flora via Upregulation of alpha-Defensin 5 Reviewed

    Tanigawa Tetsuya, Otani Koji, Watanabe Toshio, Nadatani Yuji, Yamagami Hirokazu, Shiba Masatsugu, Watanabe Kenji, Tominaga Kazunari, Fujiwara Yasuhiro, Arakawa Tetsuo

    DIGESTION   89 ( 1 )   86 - 86   2014( ISSN:0012-2823

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  • Primary Small Intestinal Mucosa-associated Lymphoid Tissue Lymphoma Diagnosed by Balloon-assisted Enteroscopy Reviewed

    Nadatani Yuji, Tanigawa Tetsuya, Fukunaga Shusei, Kinoshita Yosuke, Ominami Masaki, Obayashi Tomoko, Morimoto Kenichi, Sogawa Mitsue, Yamagami Hirokazu, Shiba Masatsugu, Watanabe Kenji, Watanabe Toshio, Tominaga Kazunari, Fujiwara Yasuhiro, Arakawa Tetsuo

    一般社団法人 日本内科学会 INTERNAL MEDICINE   53 ( 23 )   2671 - 2674   2014( ISSN:0918-2918

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    A 78-year-old Japanese woman presented with anemia. Oral double-balloon endoscopy (DBE) detected multiple ulcerative lesions covered with coagula extending up to approximately 20 cm from the mid-jejunum. Based on the histopathological findings, the patient's condition was diagnosed as mucosa-associated lymphoid tissue (MALT) lymphoma of the small intestine. During the second DBE examination, a small intestinal perforation occurred in one of the ulcerative lesions, and an emergency segmental small intestinal resection was performed. The present case suggests that in MALT lymphoma, intestinal wall fragility may lead to perforation even though the lesion may appear to be a superficial ulcer on endoscopy.<br>

    DOI: 10.2169/internalmedicine.53.2271

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  • Rome III classification and characteristics of Japanese patients with functional dyspepsia Reviewed

    TOMINAGA Kazunari, FUJIKAWA Yoshiko, TANAKA Fumio, TANIGAWA Tetsuya, SHIBA Masatsugu, WATANABE Toshio, FUJIWARA Yasuhiro, ARAKAWA Tetsuo

    The Japanese Society of Gastroenterology, Nippon Shokakibyo Gakkai Zasshi   111 ( 6 )   1079 - 1087   2014( ISSN:0446-6586

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    DOI: 10.11405/nisshoshi.111.1079

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  • High-Mobility Group Box 1 Inhibits Gastric Ulcer Healing through Toll-Like Receptor 4 and Receptor for Advanced Glycation End Products Reviewed

    Nadatani Yuji, Watanabe Toshio, Tanigawa Tetsuya, Ohkawa Fumikazu, Takeda Shogo, Higashimori Akira, Sogawa Mitsue, Yamagami Hirokazu, Shiba Masatsugu, Watanabe Kenji, Tominaga Kazunari, Fujiwara Yasuhiro, Takeuchi Koji, Arakawa Tetsuo

    PLOS ONE   8 ( 11 )   e80130   2013.11( ISSN:1932-6203

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    DOI: 10.1371/journal.pone.0080130

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  • Mesenchymal stem cells administered in the early phase of tumorigenesis inhibit colorectal tumor development in rats Reviewed

    Katsuno Takayuki, Ochi Masahiro, Tominaga Kazunari, Tanaka Fumio, Sogawa Mitsue, Tanigawa Tetsuya, Yamagami Hirokazu, Shiba Masatsugu, Watanabe Kenji, Watanabe Toshio, Fujiwara Yasuhiro, Arakawa Tetsuo

    日本酸化ストレス学会 JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION   53 ( 3 )   170 - 175   2013.11( ISSN:0912-0009

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    To investigate the differences between the effects of mesenchymal stem cells (MSCs) administered in the early and late phases of tumorigenesis, MSCs were isolated from bone marrow and colorectal tumors were produced by exposing 7-week-old F344 rats to 1,2-dimethylhydrazine and dextran sulfate sodium. We evaluated tumor number and volume (week 25), MSC localization, number of aberrant crypt foci (ACF), transforming growth factor (TGF)-β1 protein levels in the rectum after administration of MSCs (week 5 or 15), and the effects of MSC-conditioned medium on ACL15 cell proliferation. Administered MSCs labeled with PKH26 were observed in the rectum. Administered MSCs in the early phase (week 5) before tumor occurrence (week 12) significantly decreased tumor number and volume (1.5 vs 4 and 21 mm<sup>3</sup> vs 170 mm<sup>3</sup>; <i>p</i><0.01), but not administered MSCs in the late phase (week 15). Administered MSCs in the early phase reduced ACF number on days 14 and 35 (1.9 vs 4.1 and 3.7 vs 7.3; <i>p</i><0.01). Rectal TGF-β1 increased 1.3 fold on day 3, and MSC-conditioned medium containing TGF-β1 abundantly inhibited ACL15 cell proliferation. MSCs administered in the early phase but not late phase inhibited colorectal tumor development in a rat model.

    DOI: 10.3164/jcbn.13-68

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  • ラットにおける早期の発がん部位への間質系幹細胞の投与は結腸直腸がんの進行を抑制する(Mesenchymal stem cells administered in the early phase of tumorigenesis inhibit colorectal tumor development in rats) Reviewed

    Katsuno Takayuki, Ochi Masahiro, Tominaga Kazunari, Tanaka Fumio, Sogawa Mitsue, Tanigawa Tetsuya, Yamagami Hirokazu, Shiba Masatsugu, Watanabe Kenji, Watanabe Toshio, Fujiwara Yasuhiro, Arakawa Tetsuo

    (一社)日本酸化ストレス学会 Journal of Clinical Biochemistry and Nutrition   53 ( 3 )   170 - 175   2013.11( ISSN:0912-0009

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    早期および後期の発がんにおける間葉系幹細胞(MSCs)の影響の差を解析するために著者等はMSCsを骨髄から単離した。7週齢のF344系ラットに1,2-ジメチルヒドラジンとデキストラン硫酸ナトリウムを投与して結腸直腸がんを発症させた。MSCs投与後の腫瘍の数と体積(25週)、MSCの局在、異常腺窩巣(ACF)の数、直腸のトランスフォーミング増殖因子(TGF)-β1タンパク質量(5または15週)、およびACL15細胞の増殖に対するMSC制限培地の効果について解析を行った。その結果、PKH26で標識したMSCsが直腸で確認できた。がん発症(12週)前の早期(5週)でのMSCs投与は腫瘍の数と体積を有意に低下させたが(それぞれ1.5対4.0個と21対170mm3、P<0.01)、後期(15週)でのMSC投与では低下が見られなかった。早期のMSCs投与は14日と35日におけるACF数を減少させた。結腸のTGF-β1量は3日目に1.3倍に増加し、TGF-β1を含むMSC制限培地はACL15細胞の増殖を強く抑制した。以上の結果から、ラット病態モデルにおいてはMSCsを後期ではなく早期に投与することにより結腸直腸がんの進行が抑制されることが示された。

  • Covered Self-Expandable Metal Stents With an Anti-Migration System Improve Patency Duration Without Increased Complications Compared With Uncovered Stents for Distal Biliary Obstruction Caused by Pancreatic Carcinoma: A Randomized Multicenter Trial Reviewed

    Kitano Masayuki, Yamashita Yukitaka, Tanaka Kiyohito, Konishi Hideyuki, Yazumi Shujiro, Nakai Yoshitaka, Nishiyama Osamu, Uehara Hiroyuki, Mitoro Akira, Sanuki Tsuyoshi, Takaoka Makoto, Koshitani Tatsuya, Arisaka Yoshifumi, Shiba Masatsugu, Hoki Noriyuki, Sato Hideki, Sasaki Yuichi, Sato Masako, Hasegawa Kazunori, Kawabata Hideaki, Okabe Yoshihiro, Mukai Hidekazu

    AMERICAN JOURNAL OF GASTROENTEROLOGY   108 ( 11 )   1713 - 1722   2013.11( ISSN:0002-9270

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    DOI: 10.1038/ajg.2013.305

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  • 【PPI抵抗性胃食道逆流症の現状と治療戦略】多チャンネル食道インピーダンス-pHモニタリングを用いたPPI抵抗性NERDの病態分類とbaseline impedanceの関連 Reviewed

    木幡 幸恵, 藤原 靖弘, 沢田 明也, 平本 慶子, 朴 成華, 中原 憲一, 谷川 徹也, 山上 博一, 斯波 将次, 渡辺 憲治, 渡辺 俊雄, 富永 和作, 荒川 哲男

    (有)科学評論社 消化器内科   57 ( 4 )   422 - 425   2013.10( ISSN:1884-2895

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    PPI倍量投与でも症状改善しないNERD患者29例の病態をMII-pHモニタリングに基づいて分類し、病態別の臨床的特徴およびbaseline impedanceとの関係について検討した。MII-pHモニタリングによるall reflux percent timeや逆流回数などのパラメータが正常値を超えるもの、もしくはSI≧50%のものを"逆流関連あり群"とし、そうでないものを"逆流関連なし群"とすると、逆流関連あり群は21例(72%)、逆流関連なし群は8例(28%)であった。逆流関連あり例のうち、acid percent timeが正常を超えるもの、もしくは症候性逆流が酸逆流中心のものを"酸逆流関連群"とし、acid percent timeが正常範囲内で症候性逆流がnon-acid中心のものを"非酸逆流関連群"とすると、酸逆流関連群は6例(29%)、非酸逆流関連群は15例(71%)であった。逆流関連なし群のうち、2例は嚥下困難による仮性唾液分泌過多症、1例は非特異的食道運動障害と診断され、残りの5例が機能性胸やけと考えられた。逆流関連あり群と機能性胸やけ群とで「年齢」「性別」「BMI」「喫煙率」「飲酒率」「ヘルニアの有無」「萎縮性胃炎の有無」「胃内pH<4(%)」を比較したところ、「胃内pH<4(%)」に有意差が認められ、逆流関連あり群が39.4±29.3、機能性胸やけ群が9.0±8.6であった。酸逆流関連群と非酸逆流関連群および逆流関連なし群の3群間でbaseline impedanceを比較したところ、酸逆流関連群が他の2群に比べて有意に低値であった。

  • Spontaneously Occurring Widespread Laceration and Bleeding in a Patient with Gastric Sarcoidosis during an Endoscopic Examination Reviewed

    OBAYASHI Tomoko, TOMINAGA Kazunari, FUKUNAGA Shusei, NAGAMI Yasuaki, SUGIMORI Satoshi, TANIGAWA Tetsuya, SHIBA Masatsugu, WATANABE Toshio, FUJIWARA Yasuhiro, ARAKAWA Tetsuo

    Japan Gastroenterological Endoscopy Society, GASTROENTEROLOGICAL ENDOSCOPY   55 ( 9 )   "3102 - 8"   2013.09( ISSN:03871207

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    A 68-year-old woman had visited a medical clinic because of abdominal bloating. Endoscopic examination had shown diffuse granular lesions in the entire stomach. Histological examination of the lesions revealed non-caseous granulomas. After clinically differentiation such as various diseases such as Crohn's disease, tuberculosis, or histoplasmosis, she had been diagnosed as having gastric sarcoidosis. Esophagogastrodudenoscopy (EGD) had been performed once a year as an annual screening. During a follow-up EGD on April 2011, lacerations with bleeding spontaneously occurred at the lesser curvature from the middle to the upper parts of the stomach. Thus, she was admitted to our hospital. Three days later, follow-up EGD examination showed improvement in the gastric lesions, and she was discharged from our hospital. It is important to gently manipulate the scope without excessive air insufflation in patients with gastric sarcoidosis because of mucosal friability.

    DOI: 10.11280/gee.55.3102

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  • 上部消化管内視鏡検査中に広範囲に胃粘膜裂創を来した胃サルコイドーシスの1例 Reviewed

    大林 倫子, 富永 和作, 福永 周生, 永見 康明, 杉森 聖司, 谷川 徹也, 斯波 将次, 渡辺 俊雄, 藤原 靖弘, 荒川 哲男

    (一社)日本消化器内視鏡学会 Gastroenterological Endoscopy   55 ( 9 )   3102 - 3108   2013.09( ISSN:0387-1207

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    症例は68歳女性。腹部膨満感を主訴に近医を受診、上部消化管内視鏡検査(EGD)による胃粘膜生検にて非乾酪性肉芽腫性病変を認めた。全身精査にて胃サルコイドーシスと診断した。翌年経過観察のEGDにて胃体下部から体上部小彎にかけて出血を伴う多数の粘膜裂創を認め同日緊急入院となった。絶食後3日目のEGDにて粘膜裂創は治癒傾向であった。消化管サルコイドーシス患者の内視鏡操作は粘膜の脆弱性を考慮することが重要であると思われた。(著者抄録)

  • THE ROLE OF KLOTHO, AN AGING SUPPRESSOR, IN GASTRIC ULCER HEALING Reviewed

    TANIGAWA Tetsuya, WATANABE Toshio, NADATANI Yuji, OTANI Koji, SOGAWA Mitsue, YAMAGAMI Hirokazu, SHIBA Masatsugu, WATANABE Kenji, TOMINAGA Kazunari, FUJIWARA Yasuhiro, ARAKAWA Tetsuo

    40 ( 1 )   64 - 68   2013.05( ISSN:09163301

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  • 胃潰瘍治癒過程におけるアンチエイジング分子Klothoの発現動態と胃潰瘍治癒に及ぼす影響 Reviewed

    谷川 徹也, 渡辺 俊雄, 灘谷 祐二, 大谷 恒史, 十河 光栄, 山上 博一, 斯波 将次, 渡辺 憲治, 富永 和作, 藤原 靖弘, 荒川 哲男

    (一社)日本潰瘍学会 潰瘍   40   64 - 68   2013.05( ISSN:2189-7956

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    胃潰瘍治癒過程におけるアンチエイジング分子Klothoの発現動態と胃潰瘍治癒に及ぼす影響について検討した。7週齢雄性C57BL/6マウスを使用した。開腹して胃を露出させ、60%酢酸を30秒間漿膜側胃壁に接触させることにより潰瘍を作製した。胃においてKlothoの発現は主に胃上皮細胞に認めた。胃潰瘍組織におけるKlothoのmRNA発現は健常組織に比較して約1/5に低下し、胃潰瘍組織におけるFGF23のmRNA発現は健常胃組織に比較して著明にmRNAの発現が亢進した。マウスリコンビナントKlothoの腹腔内投与はDay7における潰瘍面積をコントロール群に比し有意に縮小させた。KlothoおよびFGF23の添加は胃上皮細胞(MKN7およびAGS)の細胞増殖を有意に亢進させた。

  • 【原因不明消化管出血の診断と治療】当院における原因不明消化管出血症例の検討 Reviewed

    岡本 純一, 富永 和作, 杉森 聖司, 大林 倫子, 加藤 邦洋, 南野 弘明, 大南 雅揮, 灘谷 裕二, 中山 佐容子, 福永 周生, 永見 康明, 岡崎 博俊, 斯波 将次, 渡辺 俊雄, 藤原 靖弘, 荒川 哲男

    (有)科学評論社 消化器内科   56 ( 5 )   517 - 523   2013.05( ISSN:1884-2895

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    2005年1月〜2012年1月の間にカプセル内視鏡(CE)またはバルーン内視鏡(BAE)を施行した原因不明消化管出血(OGIB)446症例(occult OGIBが107例、overt OGIBが339例、CEが362例、BAEが224例)を対象に後方視的に検討した。その結果、1)小腸病変の診断率はoccult OGIB群では潰瘍性病変30例(28.0%)、血管性病変11例(10.3%)、腫瘍性病変31例(13.1%)に認められ、全病変に対する診断率は55.1%であった。2)overt OGIB群では潰瘍性病変86例(25.4%)、血管性病変64例(18.9%)、腫瘍性病変31例(9.1%)に認められ、全病変に対する診断率は60.2%であった。両群間に有意差はみられず、病変別では血管性病変の診断率がovert OGIB群の方が有意に高かった。3)病変別の背景因子の検討ではびらんを含む潰瘍性病変ではNSAIDs内服が、血管性病変では年齢・抗凝固薬内服・透析・最低Hb値が、腫瘍性病変では男性・透析・最低Hb値が関連危険因子であった。4)CEとBAEの選択に関してはそれぞれの特性を理解して検査法を選択すべきであり、検査前の最低Hb値が低い症例では積極的かつ早期に小腸内視鏡検査を行う必要があると考えられた。

  • Cytoglobin May Be Involved in the Healing Process of Gastric Mucosal Injuries in the Late Phase Without Angiogenesis Reviewed

    Tanaka Fumio, Tominaga Kazunari, Sasaki Eiji, Sogawa Mitsue, Yamagami Hirokazu, Tanigawa Tetsuya, Shiba Masatsugu, Watanabe Kenji, Watanabe Toshio, Fujiwara Yasuhiro, Kawada Norifumi, Yoshizato Katsutoshi, Arakawa Tetsuo

    DIGESTIVE DISEASES AND SCIENCES   58 ( 5 )   1198 - 1206   2013.05( ISSN:0163-2116

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    DOI: 10.1007/s10620-012-2514-8

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  • Rebamipide inhibits indomethacin-induced small intestinal injury: Possible involvement of intestinal microbiota modulation by upregulation of alpha-defensin 5 Reviewed

    Tanigawa Tetsuya, Watanabe Toshio, Otani Koji, Nadatani Yuji, Ohkawa Fumikazu, Sogawa Mitsue, Yamagami Hirokazu, Shiba Masatsugu, Watanabe Kenji, Tominaga Kazunari, Fujiwara Yasuhiro, Takeuchi Koji, Arakawa Tetsuo

    EUROPEAN JOURNAL OF PHARMACOLOGY   704 ( 1-3 )   64 - 69   2013.03( ISSN:0014-2999

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    DOI: 10.1016/j.ejphar.2013.02.010

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  • Incidence and risk factors of gastrointestinal bleeding in patients on low-dose aspirin therapy after percutaneous coronary intervention in Japan Reviewed

    Nadatani Yuji, Watanabe Toshio, Tanigawa Tetsuya, Sogawa Mitsue, Yamagami Hirokazu, Shiba Masatsugu, Watanabe Kenji, Tominaga Kazunari, Fujiwara Yasuhiro, Yoshiyama Minoru, Arakawa Tetsuo

    SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY   48 ( 3 )   320 - 325   2013.03( ISSN:0036-5521

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    DOI: 10.3109/00365521.2012.758771

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  • Promising pharmacological therapy for FGID in the future Reviewed

    TOMINAGA Kaztunari, FUJIKAWA Yoshiko, TANAKA Fumio, SOGAWA Mitsue, YAMAGAMI Hirokazu, TANIGAWA Tetsuya, SHIBA Masatsugu, WATANABE Kenji, WATANABE Toshio, FUJIWARA Yasuhiro, ARAKAWA Tetsuo

    The Japanese Society of Internal Medicine, Nihon Naika Gakkai Zasshi   102 ( 1 )   96 - 104   2013.01( ISSN:0021-5384

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    DOI: 10.2169/naika.102.96

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  • 喉頭癌放射線治療後の異時性下咽頭癌に対してESDを施行し,咽頭気管瘻を形成した1例 Reviewed

    永見 康明, 斯波 将次, 藤原 靖弘, 荒川 哲男, 寺西 裕一, 松下 直樹, 和田 匡史, 井口 広義

    耳鼻咽喉科展望会 耳鼻咽喉科展望   56 ( 3 )   145 - 145   2013( ISSN:0386-9687

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    DOI: 10.11453/orltokyo.56.145

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  • Toll-like receptor 9 signaling has anti-inflammatory effects on the early phase of Helicobacter pylori-induced gastritis Reviewed

    Otani Koji, Tanigawa Tetsuya, Watanabe Toshio, Nadatani Yuji, Sogawa Mitsue, Yamagami Hirokazu, Shiba Masatsugu, Watanabe Kenji, Tominaga Kazunari, Fujiwara Yasuhiro, Arakawa Tetsuo

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   426 ( 3 )   342 - 349   2012.09( ISSN:0006-291X

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    DOI: 10.1016/j.bbrc.2012.08.080

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  • Final Result of a Prospective Non-Randomized Study for Accuracy of Detection and Diagnosis of Esophageal Squamous Cell Carcinoma by Tandem Non-Magnifying Endoscopy With Narrow-Band Imaging and Iodine Staining Reviewed

    Nagami Yasuaki, Machida Hirohisa, Tominaga Kazunari, Nakatani Masami, Kameda Natsuhiko, Sugimori Satoshi, Okazaki Hirotoshi, Tanigawa Tetsuya, Kubo Naoshi, Shiba Masatsugu, Watanabe Kenji, Watanabe Toshio, Fujiwara Yasuhiro, Ohira Masaichi, Arakawa Tetsuo

    GASTROINTESTINAL ENDOSCOPY   75 ( 4 )   169 - 169   2012.04( ISSN:0016-5107

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  • 当院におけるH.pylori耐性菌の15年間の推移に関する検討 Reviewed

    山崎 智朗, 丸山 紘嗣, 石田 裕美, 平松 慎介, 森 あろか, 平良 高一, 佐野 弘治, 斯波 将次, 根引 浩子, 佐藤 博之

    (一社)日本潰瘍学会 潰瘍   38 ( 2 )   148 - 151   2011.09( ISSN:2189-7956

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    当院におけるHelicobacter pyloriの薬剤感受性検査データを用い、耐性菌の頻度を検討した。H.pyloriの薬剤感受性検査件数は2006年をピークに減少しており、1995年から15年間に培養されたH.pyloriのクラリスロマイシン(CAM)、アモキシシリン(AMPC)、メトロニダゾール(MNZ)に対する耐性率・非感性率を年次別に算出した結果、全国統計と同様の傾向がみられた。当院でも2008年以降はCAMの耐性率とAMPCの非感性率の上昇が認められ、今後の一次除菌率の更なる低下が危惧される。一方、MNZの非感性率は、現時点では5%程度と横ばい傾向で、二次除菌による除菌効果には期待できる。しかし、MNZの非感性率が上昇する可能性もあるため、三次除菌のレジメンの確立と早期の保険収載が望まれる。

  • HIV感染症に伴う消化管病変に関する検討 Reviewed

    根引 浩子, 丸山 紘嗣, 石田 裕美, 平松 慎介, 森 あろか, 末包 剛久, 山崎 智朗, 平良 高一, 佐野 弘治, 斯波 将次, 佐藤 博之, 後藤 哲志

    (一社)日本潰瘍学会 潰瘍   38 ( 2 )   156 - 160   2011.09( ISSN:2189-7956

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    1994年1月〜2010年3月に診断されたHIV(ヒト免疫不全ウイルス)感染症患者のうち、消化管内視鏡検査を行った80症例(男73例、女7例、平均42歳)について、内視鏡所見、消化管病変を呈した時のCD4陽性リンパ球数やHIV-RNA量を検討した。上部消化管内視鏡検査では食道カンジダ症を31%に、サイトメガロウイルス(CMV)感染症を20%に認め、約半数の症例で何らかの食道病変が観察された。また、下部消化管内視鏡検査ではアメーバ性大腸炎(30%)、CMV大腸炎(16%)が特徴的であり、内視鏡検査がきっかけでHIV感染が判明した消化管病変は食道カンジダ症、アメーバ性大腸炎、CMV感染症であった。消化管病変がHIV感染症の診断の契機となることもあり、免疫不全患者に特徴的な消化管病変の内視鏡像について熟知しておく必要があると考えられた。

  • 経皮的アブレーション術に重点を置いた、非B型肝炎ウイルス非C型肝炎ウイルス陽性肝細胞癌治療のための様々な方法に関する研究(Investigation of different methods, particularly percutaneous ablation therapy, for treating non-B, non-C hepatocellular carcinoma) Reviewed

    Koika Kiyohide, Kawasaki Yasuko, Nakai Takashi, Ishida Yumi, Maruyama Hirotsugu, Hiramatsu Shinsuke, Mori Aroka, Suekane Takehisa, Yamasaki Tomoaki, Sano Koji, Shiba Masatsugu, Nebiki Hiroko, Sato Hiroshi, Shimizu Sadatoshi, Kanazawa Akishige, Tsukamoto Tadashi

    (NPO)Microwave Surgery研究会 Journal of Microwave Surgery   29   99 - 104   2011.08( ISSN:0917-7728

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    当院にて初回治療を行った肝細胞癌患者1401例を対象に治療法について検討した。患者を、B型肝炎ウイルス抗体陽性158例(B群)とC型肝炎ウイルス抗体陽性1044例(C群)、両抗体陰性例の199例(非B非C群)の3群に分け、背景因子、治療法、予後を検討した。その結果、非B非C群の平均年齢は68歳でB群の58歳に比べ有意に高かった。C群と比べ非B非C群に有意差が見られたのは、男性患者の比率(C群67%、非B非C群77%)、輸血歴(C群26%、非B非C群11%)、グレードAの肝障害の患者比率(C群46%、非B非C群64%)、平均血小板数(C群120000/μl、非B非C群160000/μl)、腫瘍径(C群3.2cm、非B非C群4.7cm)であった。腫瘍進行度も非B非C群の方が高く、ビタミンKアンタゴニストII誘導タンパク質陽性率はC群の方が低かった。また、他の2群に比べ、非B非C群では大量飲酒歴と他臓器に悪性腫瘍のある患者が有意に多く、αフェトプロテイン陽性率は低かった。初回治療として非B非C群では肝切除、経皮アブレーション(Abl)、経カテーテル肝動脈塞栓術(TAE)、Abl+TAEを行い、その比率はそれぞれ43%、13%、12%、19%であった。B群、C群ではそれぞれB群:52%、9%、14%、16%、C群:34%、22%、13%、25%であった。3群間での全生存率、累積生存率には有意差は見られなかった。

  • 治療後タンパク質陰性化との関連におけるαフェトプロテイン-レクチン分画陽性肝細胞癌に対する治療成績の分析(Analysis of treatment outcome for lens culinaris agglutinin-reactive alpha-fetoprotein-positive hepatocellular carcinoma in relation to post-treatment disappearance of protein) Reviewed

    Kawasaki Yasuko, Kioka Kiyohide, Nakai Takashi, Ishida Yumi, Maruyama Hirotsugu, Hiramatsu Shinsuke, Mori Aroka, Suekane Takehisa, Yamasaki Tomoaki, Sano Koji, Shiba Masatsugu, Nebiki Hiroko, Sato Hiroyuki, Kanazawa Akishige, Shimizu Sadatoshi, Tsukamoto Tadashi

    (NPO)Microwave Surgery研究会 Journal of Microwave Surgery   29   109 - 113   2011.08( ISSN:0917-7728

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    肝細胞癌232例を対象に、αフェトプロテイン(AFP)-レクチン(L3)陽性の影響について検討した。232例中L3陽性は39例(平均年齢67.5±7.4歳、男12例、女27例)、陰性は193例(平均年齢67.5±8.7歳、男114例、女79例)であった。肝障害の重症度A/Bはそれぞれ陽性例14/25、陰性例109/84で、肝障害の原因はHCV/HBV/その他とするとそれぞれ陽性例28/8/3、陰性例160//13/2であった。累積生存率は陽性例が陰性例に比べ有意に低かったが、陽性例中の治療法の違いでは有意差は見られなかった。治療後にL3が陰性化した例は35例中25例であった。陰性化例と非陰性化例との比較では、治療法による有意差はなく、累積生存率は陰性化例で有意に高かった。

  • 【膵IPMNの手術適応の見直し】当院でのIPMN手術例より見直した手術適応 Reviewed

    根引 浩子, 丸山 紘嗣, 平松 慎介, 末包 剛久, 山崎 智朗, 佐野 弘治, 斯波 将次, 佐藤 博之, 清水 貞利, 金沢 景繁, 塚本 忠司

    (有)科学評論社 消化器内科   52 ( 6 )   670 - 675   2011.06( ISSN:1884-2895

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    1996年1月〜2009年9月の間に手術を施行した膵管内乳頭粘液腫瘍(IPMN)46例を対象に、IPMNを主膵管型と分枝型に分けて癌と腺腫の鑑別について検討した。その結果、1)IPMN主膵管型の手術例は22例(男性18例、女性4例、平均年齢67±7歳)中15例が癌で、うち12例が微小浸潤癌か浸潤癌であった。2)主膵管型IPMNにおいては主膵管径や主膵管内結節の有無や高さ、および細胞診は癌の鑑別に有用ではなく、主膵管型IPMNは全て手術適応として良いと考えられた。3)分節型IPMNの手術例は24例(男性13例、女性11例、平均年齢68±7歳、腺腫11例、癌13例)で、癌と腺腫の間で壁在結節の有無や高さ、嚢胞径に有意差が認められたが、主膵管径には有意差はみられなかった。4)癌と腺腫の鑑別におけるカットオフ値を壁在結節高7mm、嚢胞径40mm、主膵管径3mmとして、各因子について多変量解析を行ったところ、壁内結節高のみが癌と腺腫の鑑別に有意な因子であり、癌と腺腫の鑑別に最も有用であると考えられた。以上、これらのことより、IPMN手術適応は主膵管型では全例、分枝型では壁在結節高>5mmとしてよいと考えられ、分枝型IPMNの嚢胞径30mm以上の症例は厳重な経過観察が必要であると考えられた。

  • Differences between risk factors among irritable bowel syndrome subtypes in Japanese adults Reviewed

    Kubo M., Fujiwara Y., Shiba M., Kohata Y., Yamagami H., Tanigawa T., Watanabe K., Watanabe T., Tominaga K., Arakawa T.

    NEUROGASTROENTEROLOGY AND MOTILITY   23 ( 3 )   249 - 254   2011.03( ISSN:1350-1925

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    DOI: 10.1111/j.1365-2982.2010.01640.x

  • Tracking Abnormality in Video Capsule Endoscopy by using Supporters Interpolated from Image Features Reviewed

    KABASHIMA Seiichiro, HAI Vu, WANG Junqiu, ECHIGO Tomio, YAGI Yasushi, YAGI Keiko, SHIBA Masatsugu, OKAZAKI Hirotoshi, FUJIWARA Yasuhiro, ARAKAWA Tetsuo

    The Institute of Electronics, Information and Communication Engineers, IEICE technical report   110 ( 364 )   5 - 10   2011.01( ISSN:09135685

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    This paper describes a method to track abnormalities on successive frames in a capsule endoscopic image sequence. The exact tracking of abnormalities is useful for supporting diagnosis such as estimating duration appeared on images. The shape of an abnormality is changeable on the successive images, which makes it difficult to track abnormalities precisely. The proposed method uses not only abnormality image features but also surrounding features. Surrounding features, called supporters, are also difficult to track in the images, so they are treated mutually in the proposed method.

    CiNii Article

  • Differences between risk factors among irritable bowel syndrome subtypes in Japanese adults.

    Kubo M, Fujiwara Y, Shiba M, Kohata Y, Yamagami H, Tanigawa T, Watanabe K, Watanabe T, Tominaga K, Arakawa T.

    Neurogastroenterol Motil.   23 ( 2 )   249 - 54   2011

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  • Gastrointestinal Color Space and Its Application to Image Enhancement (コンピュータビジョンとイメージメディア(CVIM)) -- (一般セッション) Reviewed

    VU HAI, ECHIGO TOMIO, YAGI KEIKO, Masatsugu Shiba, Toshio Watanabe, Kazunari Tominaga, Tetsuo Arakawa, Yasushi Yagi

    情報処理学会 情報処理学会研究報告. CVIM, [コンピュータビジョンとイメージメディア]   173   D1 - D7   2010.09( ISSN:09196072

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    Color is a robust feature in computer assisted diagnosis of Video Capsule Endoscopy (VCE). This paper proposes a color space, specific to the human Gastrointestinal (GI) tract. A statistical model is constructed from a large VCE dataset, in which color components are classified into three groups: GI wall, darkness, and noise. The main cues for the clustering task are visualizing the appearance of color components and the frequency thereof. To utilize these features, a Self-Organizing Map (SOM) is deployed in a two stage semisupervised scheme. We show the effectiveness of the proposed GI space in an application of image enhancement. With prior information about available colors from the GI color space, the enhancement task turns to increasing to the maximum color contrasts in the color range of the original image. In this sense, the enhanced image preserves the natural color tones of the original image as far as possible. The experimental results show that 84% of the enhanced images exceed the baseline level and are feasible for deployment in clinical applications.Color is a robust feature in computer assisted diagnosis of Video Capsule Endoscopy (VCE). This paper proposes a color space, specific to the human Gastrointestinal (GI) tract. A statistical model is constructed from a large VCE dataset, in which color components are classified into three groups: GI wall, darkness, and noise. The main cues for the clustering task are visualizing the appearance of color components and the frequency thereof. To utilize these features, a Self-Organizing Map (SOM) is deployed in a two stage semisupervised scheme. We show the effectiveness of the proposed GI space in an application of image enhancement. With prior information about available colors from the GI color space, the enhancement task turns to increasing to the maximum color contrasts in the color range of the original image. In this sense, the enhanced image preserves the natural color tones of the original image as far as possible. The experimental results show that 84% of the enhanced images exceed the baseline level and are feasible for deployment in clinical applications.

    CiNii Article

  • Prevalence of overlaps between GERD, FD and IBS and impact on health-related quality of life Reviewed

    Kaji Makiko, Fujiwara Yasuhiro, Shiba Masatsugu, Kohata Yukie, Yamagami Hirokazu, Tanigawa Tetsuya, Watanabe Kenji, Watanabe Toshio, Tominaga Kazunari, Arakawa Tetsuo

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   25 ( 6 )   1151 - 1156   2010.06( ISSN:0815-9319

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    DOI: 10.1111/j.1440-1746.2010.06249.x

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  • 難治性胃潰瘍から診断され、十二指腸、大腸にも病変を認めたサイトメガロウイルス感染症の1例 Reviewed

    佐野 弘治, 大川 清孝, 上田 渉, 丸山 紘嗣, 石田 裕美, 有本 雄貴, 平松 慎介, 三宅 清花, 森 あろか, 末包 剛久, 斯波 将次, 根引 浩子, 中井 隆志, 川崎 靖子, 木岡 清英, 山上 啓子, 吉岡 克宣, 久保 勇気, 井上 健

    (有)科学評論社 消化器内科   50 ( 4 )   394 - 400   2010.04( ISSN:1884-2895

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    40歳代男。患者は心窩部痛および食欲低下を主訴とした。前医での上部消化管内視鏡検査で胃角部小彎に潰瘍が指摘された。加療を受けるも、1ヵ月経過で治癒傾向がないため、難治性胃潰瘍の診断にて著者らの施設へ紹介となった。所見では十二指腸下行脚、直腸下部にも潰瘍がみられ、胃潰瘍辺縁からの生検組織でcytomegalovirus(CMV)陽性細胞が検出された。だが、盲腸や直腸の潰瘍からは核内封入体やCMV陽性細胞は検出されず、CMV感染による胃、十二指腸、大腸潰瘍と診断された。一方、HIV抗体が陽性であり、HIV-RNAウイルス量も高値であった。更にCD4は高度に低下、CMV網膜症を伴っており、acquired immunodeficiency syndromeと診断された。以上より、治療はH2blockerからPPIに変更され、CMV感染症に対してはganciclovir点滴が行われた結果、4週間後には潰瘍は全て浅く、縮小した。その後、rabeprazoleを2ヵ月間使用、Ganciclovirは6週間で中止し、CMV網膜症、CMV感染予防のための内服に変更された。

  • 【消化器疾患の病態生理】胃癌における15-Hydroxyprostaglandin Dehydrogenaseの意義 Reviewed

    達脇 大, 谷川 徹也, 渡辺 俊雄, 町田 浩久, 岡崎 博俊, 山上 博一, 斯波 将次, 渡辺 憲治, 富永 和作, 藤原 靖弘, 押谷 伸英, 六車 和也, 澤田 鉄二, 平川 弘聖, 樋口 和秀, 荒川 哲男

    (株)ライフ・サイエンス Progress in Medicine   30 ( 3 )   791 - 796   2010.03( ISSN:0287-3648

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    分化型進行胃癌症例における15-Hydroxyprostaglandin Dehydrogenase(15-PGDH)の発現状態を検討し、胃癌患者の臨床病理学的因子、および予後との関連を検討した。さらに、15-PGDHの発現低下や活性低下が胃癌細胞の増殖に及ぼす影響を、病理組織および胃癌細胞株を用いて検討した。非腫瘍部の胃組織において、15-PGDHは粘膜上皮細胞の細胞質内に発現した。腫瘍組織においても、15-PGDHは腫瘍細胞の細胞質内に発現していたが、71例中35例の腫瘍組織では15-PGDHの発現は低下、もしくは消失していた。15-PGDHの発現が低下、もしくは消失している群では、15-PGDHの発現を維持している群に比較して有意に累積生存率が低下した。胃癌患者の予後に関する臨床病理学的因子として、15-PGDHの発現低下は、独立した予後不良因子であることが明らかとなった。

  • Reduction of 15-hydroxyprostaglandin dehydrogenase expression is an independent predictor of poor survival associated with enhanced cell proliferation in gastric adenocarcinoma Reviewed

    TATSUWAKI Hiroshi, TANIGAWA Tatsuya, WATANABE Toshio, MACHIDA Hirohisa, OKAZAKI Hirotoshi, YAMAGAMI Hirokazu, SHIBA Masatsugu, WATANABE Kenji, TOMINAGA Kazunari, FUJIWARA Yasuhiro, OSHITANI Nobuhide, MUGURUMA Kazuya, SAWADA Tetsuji, HIRAKAWA Kosei, HIGUCHI Kazuhide, ARAKAWA Tetsuo

    Cancer science   101 ( 2 )   550 - 558   2010.02( ISSN:13479032

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  • 胃腺癌における15-ヒドロキシプロスタグランジンデヒドロゲナーゼ発現の低下は細胞増殖亢進を伴う生存予後不良の独立した予測因子である(Reduction of 15-hydroxyprostaglandin dehydrogenase expression is an independent predictor of poor survival associated with enhanced cell proliferation in gastric adenocarcinoma) Reviewed

    Tatsuwaki Hiroshi, Tanigawa Tetsuya, Watanabe Toshio, Machida Hirohisa, Okazaki Hirotoshi, Yamagami Hirokazu, Shiba Masatsugu, Watanabe Kenji, Tominaga Kazunari, Fujiwara Yasuhiro, Oshitani Nobuhide, Muguruma Kazuya, Sawada Tetsuji, Hirakawa Kosei, Higuchi Kazuhide, Arakawa Tetsuo

    John Wiley & Sons Australia, Ltd Cancer Science   101 ( 2 )   550 - 558   2010.02( ISSN:1347-9032

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    胃腺癌の71例を対象に、標記酵素(15-PGDH)の発現を調べた。35例の腫瘍組織中で15-PGDH蛋白質の発現が低下していた。多変量解析にて、15-PGDHの発現低下は生存予後不良の独立した予測因子であった。15-PGDH陽性腺癌と比べて陰性腺癌においてKi67陽性細胞の比率が高かった。COX-2陽性腫瘍と陰性腫瘍との間で臨床病理学的な差異はなかった。15-PGDHを発現する胃癌細胞株AGSを15-PGDH特異的siRNAまたは15-PGDH特異的阻害剤で処理すると、細胞増殖が促進された。以上より、15-PGDHの低下は細胞増殖亢進を伴う生存予後不良の独立した予測因子であると考えられた。

  • Reduction of 15-hydroxyprostaglandin dehydrogenase expression is an independent predictor of poor survival associated with enhanced cell proliferation in gastric adenocarcinoma Reviewed

    Tatsuwaki Hiroshi, Tanigawa Tetsuya, Watanabe Toshio, Machida Hirohisa, Okazaki Hirotoshi, Yamagami Hirokazu, Shiba Masatsugu, Watanabe Kenji, Tominaga Kazunari, Fujiwara Yasuhiro, Oshitani Nobuhide, Muguruma Kazuya, Sawada Tetsuji, Hirakawa Kosei, Higuchi Kazuhide, Arakawa Tetsuo

    CANCER SCIENCE   101 ( 2 )   550 - 558   2010.02( ISSN:1349-7006

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    DOI: 10.1111/j.1349-7006.2009.01390.x

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  • Predictive Factors of Worsening of Esophageal Varices After Balloon-Occluded Retrograde Transvenous Obliteration in Patients With Gastric Varices Reviewed

    Elsamman Mahmoud K., Fujiwara Yasuhiro, Kameda Natsuhiko, Okazaki Hirotoshi, Tanigawa Tetsuya, Shiba Masatsugu, Tominaga Kazunari, Watanabe Toshio, Oshitani Nobuhide, Arafa Usama A., El-Sayed Adel A., Nakamura Kenji, Arakawa Tetsuo

    AMERICAN JOURNAL OF GASTROENTEROLOGY   104 ( 9 )   2214 - 2221   2009.09( ISSN:0002-9270

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    DOI: 10.1038/ajg.2008.140

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  • Video Capsule Endoscopy Analysis For Diagnostic Assistance (コンピュータビジョンとイメージメディア(CVIM) Vol.2009-CVIM-167) Reviewed

    VU HAI, ECHIGO TOMIO, SAGAWA RYUSUKE, Keiko Yagi, Masatsugu Shiba, Kazuhide Higuchi, Tetsuo Arakawa, Yasushi Yagi

    情報処理学会 情報処理学会研究報告. CVIM, [コンピュータビジョンとイメージメディア]   167   E1 - E16   2009.06( ISSN:09196072

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    Video capsule endoscopy (VCE) represents a significant advance in examinations of digestive diseases by providing a non-invasive method to view the small bowel. In addition, VCE provides a valuable source for visualizing the intestinal contractions, which are mainly events for intestinal motility assessment. However, the advantages of VCE diagnosis technique are facing with the time consuming for reading video sequence as well as challenging to detect the intestinal contractions. In this paper, we present our works to approach these motivations through techniques of VCE analysis. VCE interpretations could be implemented by analyzing spatial and temporal features. First, several image features such as color, edges, and motion displacement are extracted. Then their temporal analyses are presented in several ways to adapt with different tasks. Two applications utilizing this framework are developed. In the first application, we propose a new method to reduce diagnostic time under the constraint that all original images should be displayed to an examining doctor without skipping frames. To realize such a system, delay time for drawing images between frames is controlled in adaptive rate, according to the states of capturing images. Several techniques for the state classification, delay time calculation, and log-based analysis are deployed in this application. In the second application, we develop a three-stage procedure for the intestinal contraction detections. Based on the characteristics of contractile patterns, the possible contractions can be investigated using essential images features extracted from VCE such as changes in edge of the intestinal folds and by evaluating similarities features in consecutive frames. Then true contractions are determined through spatial analysis of directional information. To exclude as many non-contractions as possible, we consider about information of contractions frequencies along capsule transit time. Both the quality and quantity indices are analyzed in experiments for performance evaluations.Video capsule endoscopy (VCE) represents a significant advance in examinations of digestive diseases by providing a non-invasive method to view the small bowel. In addition, VCE provides a valuable source for visualizing the intestinal contractions, which are mainly events for intestinal motility assessment. However, the advantages of VCE diagnosis technique are facing with the time consuming for reading video sequence as well as challenging to detect the intestinal contractions. In this paper, we present our works to approach these motivations through techniques of VCE analysis. VCE interpretations could be implemented by analyzing spatial and temporal features. First, several image features such as color, edges, and motion displacement are extracted. Then their temporal analyses are presented in several ways to adapt with different tasks. Two applications utilizing this framework are developed. In the first application, we propose a new method to reduce diagnostic time under the constraint that all original images should be displayed to an examining doctor without skipping frames. To realize such a system, delay time for drawing images between frames is controlled in adaptive rate, according to the states of capturing images. Several techniques for the state classification, delay time calculation, and log-based analysis are deployed in this application. In the second application, we develop a three-stage procedure for the intestinal contraction detections. Based on the characteristics of contractile patterns, the possible contractions can be investigated using essential images features extracted from VCE such as changes in edge of the intestinal folds and by evaluating similarities features in consecutive frames. Then true contractions are determined through spatial analysis of directional information. To exclude as many non-contractions as possible, we consider about information of contractions frequencies along capsule transit time. Both the quality and quantity indices are analyzed in experiments for performance evaluations.

    CiNii Article

  • Prevalence of mid-gastrointestinal bleeding in patients with acute overt gastrointestinal bleeding : multi-center experience with 1,044 consecutive patients Reviewed

    OKAZAKI Hirotoshi, FUJIWARA Yasuhiro, SUGIMORI Satoshi, NAGAMI Yasuaki, KAMEDA Natsuhiko, MACHIDA Hirohisa, YAMAGAMI Hirokazu, TANIGAWA Tetsuya, SHIBA Masatsugu, WATANABE Kenji, TOMINAGA Kazunari, WATANABE Toshio, OSHITANI Nobuhide, ARAKAWA Tetsuo

    Journal of gastroenterology   44 ( 6 )   550 - 555   2009.06( ISSN:09441174

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    CiNii Article

  • Prevalence of mid-gastrointestinal bleeding in patients with acute overt gastrointestinal bleeding: multi-center experience with 1,044 consecutive patients Reviewed

    Okazaki Hirotoshi, Fujiwara Yasuhiro, Sugimori Satoshi, Nagami Yasuaki, Kameda Natsuhiko, Machida Hirohisa, Yamagami Hirokazu, Tanigawa Tetsuya, Shiba Masatsugu, Watanabe Kenji, Tominaga Kazunari, Watanabe Toshio, Oshitani Nobuhide, Arakawa Tetsuo

    JOURNAL OF GASTROENTEROLOGY   44 ( 6 )   550 - 555   2009.06( ISSN:0944-1174

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    DOI: 10.1007/s00535-009-0039-5

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  • Controlling the Display of Capsule Endoscopy Video for Diagnostic Assistance Reviewed

    Vu Hai, Echigo Tomio, Sagawa Ryusuke, Yagi Keiko, Shiba Masatsugu, Higuchi Kazuhide, Arakawa Tetsuo, Yagi Yasushi

    一般社団法人 電子情報通信学会 IEICE TRANSACTIONS ON INFORMATION AND SYSTEMS   E92D ( 3 )   512 - 528   2009.03( ISSN:1745-1361

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    Interpretations by physicians of capsule endoscopy image sequences captured over periods of 7-8 hours usually require 45 to 120 minutes of extreme concentration. This paper describes a novel method to reduce diagnostic time by automatically controlling the display frame rate. Unlike existing techniques, this method displays original images with no skipping of frames. The sequence can be played at a high frame rate in stable regions to save time. Then, in regions with rough changes, the speed is decreased to more conveniently ascertain suspicious findings. To realize such a system, cue information about the disparity of consecutive frames, including color similarity and motion displacements is extracted. A decision tree utilizes these features to classify the states of the image acquisitions. For each classified state, the delay time between frames is calculated by parametric functions. A scheme selecting the optimal parameters set determined from assessments by physicians is deployed. Experiments involved clinical evaluations to investigate the effectiveness of this method compared to a standard-view using an existing system. Results from logged action based analysis show that compared with an existing system the proposed method reduced diagnostic time to around 32.5 &plusmn; minutes per full sequence while the number of abnormalities found was similar. As well, physicians needed less effort because of the systems efficient operability. The results of the evaluations should convince physicians that they can safely use this method and obtain reduced diagnostic times.

    DOI: 10.1587/transinf.E92.D.512

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  • Detection of contractions in adaptive transit time of the small bowel from wireless capsule endoscopy videos Reviewed

    Vu Hai, Echigo Tomio, Sagawaa Ryusuke, Yagi Keiko, Shiba Masatsugu, Higuchi Kazuhide, Arakawa Tetsuo, Yagi Yasushi

    COMPUTERS IN BIOLOGY AND MEDICINE   39 ( 1 )   16 - 26   2009.01( ISSN:0010-4825

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    DOI: 10.1016/j.compbiomed.2008.10.005

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  • Prevalence of mid-gastrointestinal bleeding in patients with acute overt gastrointestinal bleeding: multi-center experience with 1,044 consecutive patients.

    Okazaki H, Fujiwara Y, Sugimori S, anigawa T, Shiba M, Watanabe K, Tominaga K, Watanabe T, Oshitani N, Arakawa T.

    J Gastroenterol   44 ( 6 )   550 - 5   2009

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  • The efficacy of double balloon enteroscopy for patients with intestinal lymphangiectasia, case report of primary intestinal lymphangiectasia Reviewed

    YAKAMI Yoshikazu, WATANABE Kenji, KAMEDA Natsuhiko, MACHIDA Hiroshi, OKAZAKI Hirotoshi, YAMAGAMI Hirokazu, SHIBA Masatsugu, FUJIWARA Yasuhiro, OSHITANI Nobuhide, ARAKAWA Tetsuo

    The Japanese Society of Gastroenterology, Nippon Shokakibyo Gakkai Zasshi   105 ( 11 )   1612 - 1618   2008.11( ISSN:04466586

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    A 31-year-old man has visited our hospital, complaining diarrhea and leg edema.<br> Blood test showed hypoalbuminea, but we couldn't find the reason by several examinations.<br> Therefore, we performed double balloon enteroscopy, and intestinal lymphangiectasia was diagnosed histologically by biopsy.<br> It's useful and effective to perform double balloon enteroscopy and histological examination for the unknown origin case of protein loosing enteropathy.<br>

    DOI: 10.11405/nisshoshi.105.1612

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  • [Efficacy of double balloon enteroscopy for patients with intestinal lymphangiectasia, case report of primary intestinal lymphangiectasia]. Reviewed

    Yakami Y, Watanabe K, Kameda N, Machida H, Okazaki H, Yamagami H, Shiba M, Fujiwara Y, Oshitani N, Arakawa T

    Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology   105 ( 11 )   1612 - 8   2008.11( ISSN:0446-6586

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  • Perfectionism underlying psychological background correlated with the symptoms of functional dyspepsia Reviewed

    OCHI MASAHIRO, TOMINAGA KAZUNARI, IKETANI TOSHIYA, KADOUCHI KAORI, TANIGAWA TETSUYA, SHIBA MASATSUGU, WATANABE TOSHIO, FUJIWARA YASUHIRO, OSHITANI NOBUHIDE, HIGUCHI KAZUHIDE, KIRIIKE NOBUO, ARAKAWA TETSUO

    Journal of gastroenterology   43 ( 9 )   699 - 704   2008.09( ISSN:09441174

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  • Perfectionism underlying psychological background correlated with the symptoms of functional dyspepsia Reviewed

    Ochi Masahiro, Tominaga Kazunari, Iketani Toshiya, Kadouchi Kaori, Tanigawa Tetsuya, Shiba Masatsugu, Watanabe Toshio, Fujiwara Yasuhiro, Oshitani Nobuhide, Higuchi Kazuhide, Kiriike Nobuo, Arakawa Tetsuo

    JOURNAL OF GASTROENTEROLOGY   43 ( 9 )   699 - 704   2008.09( ISSN:0944-1174

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    DOI: 10.1007/s00535-008-2210-9

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  • Omnidirectional Vision Attachment for Medical Endoscope Reviewed

    SAKAI Takurou, SAGAWA Ryusuke, ECHIGO Tomio, YAGI Keiko, SHIBA Masatsugu, HIGUCHI Kazuhide, ARAKAWA Tetsuo, YAGI Yasushi

    The Institute of Electronics, Information and Communication Engineers, The IEICE transactions on information and systems   91 ( 7 )   1778 - 1787   2008.07( ISSN:18804535

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  • A prospective, single-blind trial comparing wireless capsule endoscopy and double-balloon enteroscopy in patients with obscure gastrointestinal bleeding Reviewed

    KAMEDA NATSUHIKO, HIGUCHI KAZUHIDE, SHIBA MASATSUGU, MACHIDA HIROHISA, OKAZAKI HIROTOSHI, YAMAGAMI HIROKAZU, TANIGAWA TETSUYA, WATANABE KENJI, WATANABE TOSHIO, TOMINAGA KAZUNARI, FUJIWARA YASUHIRO, OSHITANI NOBUHIDE, ARAKAWA TETSUO

    Journal of gastroenterology   43 ( 6 )   434 - 440   2008.06( ISSN:09441174

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  • Small dense LDL-cholesterol is a superior diagnostic marker for familiar combined hyperlipidemia Reviewed

    Ito Y., Meguro Y., Hirano T., Kinoshita M., Shiba M., Shoji T., Koba S., Ikewaki K., Kamata K., Yoshino G.

    CLINICAL CHEMISTRY   54 ( 6 )   A145 - A145   2008.06( ISSN:0009-9147

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  • Biliary Drainage with Stents for Malignant Hilar stricture : A multi-center Evaluation in Clinical Study Committee for Endoscopic Device Selection Conference in Kansai Reviewed

    KUBOTA Yoshitsugu, MUKAI Hidekazu, TANAKA Kiyohito, OKABE Yoshihiro, KITANO Masayuki, KIKUCHI Eiryo, KOYAMA Shigeki, YAZUMI Shujiro, SHIBA Masatsugu, YASUDA Kenjiro

    22 ( 2 )   160 - 168   2008.05( ISSN:09140077

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  • DIAGNOSIS OF FAMILIAR COMBINED HYPERLIPIDEMIA BY SMALL DENSE LDL-CHOLESTEROL Reviewed

    Ito Y., Hirano T., Kinoshita M., Shiba M., Shoji T., Koba S., Ikewaki K., Yoshino G.

    ATHEROSCLEROSIS SUPPLEMENTS   9 ( 1 )   152 - 153   2008.05( ISSN:1567-5688

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  • A novel rat model to determine interaction between reflux oesophagitis and bronchial asthma Reviewed

    Sugawa T., Fujiwara Y., Yamagami H., Watanabe K., Tanigawa T., Shiba M., Watanabe T., Tominaga K., Oshitani N., Higuchi K., Arakawa T.

    GUT   57 ( 5 )   575 - 581   2008.05( ISSN:0017-5749

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    DOI: 10.1136/gut.2007.138461

  • Effect of chronic stress on gastric emptying and plasma ghrelin levels in rats Reviewed

    Ochi Masahiro, Tominaga Kazunari, Tanaka Fumio, Tanigawa Tetsuya, Shiba Masatsugu, Watanabe Toshio, Fujiwara Yasuhiro, Oshitani Nobuhide, Higuchi Kazuhide, Arakawa Tetsuo

    LIFE SCIENCES   82 ( 15-16 )   862 - 868   2008.04( ISSN:0024-3205

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    DOI: 10.1016/j.lfs.2008.01.020

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  • ACTIVE GHRELIN, AUTONOMIC NERVOUS SYSTEM, AND NITRIC OXIDE INDUCED BY iNOS HAVE INFLUENCED FOR GASTRIC EMPTYING UNDER CONTINUOUS STRESS IN RATS Reviewed

    OCHI Masahiro, TOMINAGA Kazunari, TANIGAWA Tetsuya, SHIBA Masatsugu, WATANABE Toshio, FUJIWARA Yasuhiro, OSHITANI Nobuhide, HIGUCHI Kazuhide, ARAKAWA Tetsuo

    35 ( 1 )   13 - 16   2008.03( ISSN:09163301

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  • ACTIVATION OF TOLL-LIKE RECEPTOR 4/MYD88 SIGNALING PATHWAY BY GRAM NEGATIVE BACTERIA PLAYS AN IMPORTANT ROLE IN THE PATHOGENESIS OF NSAIDS-INDUCED SMALL INTESTINAL DAMAGE Reviewed

    WATANABE Toshio, TANIGAWA Tetsuya, SHIBA Masatsugu, TOMINAGA Kazunari, FUJIWARA Yasuhiro, OSHITANI Nobuhide, HIGUCHI Kazuhide, ARAKAWA Tetsuo

    35 ( 1 )   35 - 38   2008.03( ISSN:09163301

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  • Concurrent assessment of reservoir and emptying of the stomach for dyspepsia patients. Reviewed

    Tominaga K, Higuchi K, Ochi M, Kadouchi K, Kawamura E, Tanigawa T, Shiba M, Watanabe T, Fujiwara Y, Oshitani N, Shiomi S, Arakawa T

    Hepato-gastroenterology   55 ( 82-83 )   744 - 9   2008.03( ISSN:0172-6390

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  • Non-steroidal anti-inflammatory drug-induced small intestinal damage is Toll-like receptor 4 dependent Reviewed

    Watanabe T., Higuchi K., Kobata A., Nishio H., Tanigawa T., Shiba M., Tominaga K., Fujiwara Y., Oshitani N., Asahara T., Nomoto K., Takeuchi K., Arakawa T.

    GUT   57 ( 2 )   181 - 187   2008.02( ISSN:0017-5749

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    DOI: 10.1136/gut.2007.125963

  • Management of gastric fundal varices without gastro-renal shunt in 15 patients. Reviewed

    Kameda N, Higuchi K, Shiba M, Kadouchi K, Machida H, Okazaki H, Tanigawa T, Watanabe T, Tominaga K, Fujiwara Y, Nakamura K, Arakawa T

    World journal of gastroenterology   14 ( 3 )   448 - 53   2008.01( ISSN:1007-9327

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    DOI: 10.3748/wjg.14.448

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  • Management of gastric fundal varices without gastro-renal shunt in 15 patients Reviewed

    Kameda Natsuhiko, Higuchi Kazuhide, Shiba Masatsugu, Kadouchi Kaori, Machicla Hirohisa, Okazaki Hirotoshi, Tanigawa Tetsuya, Watanabe Toshio, Tominaga Kazunari, Fujiwara Yasuhiro, Nakamura Kenji, Arakawa Tetsuo

    WORLD JOURNAL OF GASTROENTEROLOGY   14 ( 3 )   448 - 453   2008.01( ISSN:1007-9327

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  • Small bowel injury in patients with rheumatoid arthritis by capsule endoscopy - Effect of nonsteroidal anti-inflammatory drugs Reviewed

    Xu Y., Watanabe T., Sugimori S., Tabuchi M., Kameda N., Kadouchi K., Machida H., Okazaki H., Sogawa M., Yamagami H., Tanigawa T., Shiba M., Watanabe K., Tominaga K., Fujiwara Y., Oshitani N., Koike T., Higuchi K., Arakawa T.

    DIGESTION   77   62 - 62   2008( ISSN:0012-2823

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  • Biliary Drainage with Stents for Malignant Hilar stricture: A multi-center Evaluation in Clinical Study Committee for Endoscopic Device Selection Conference in Kansai Reviewed

    Kubota Yoshitsugu, Yasuda Kenjiro, Mukai Hidekazu, Tanaka Kiyohito, Okabe Yoshihiro, Kitano Masayuki, Kikuchi Eiryo, Koyama Shigeki, Yazumi Shujiro, Shiba Masatsugu

    Japan Biliary Association, Tando   22 ( 2 )   160 - 168   2008( ISSN:0914-0077

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    Palliation of unresectable malignant hilar biliary stricture is controversial with respect to optimal types of stents and extent of drainage. A consecutive series of 92 patients from 13 institutions with unresectable malignant hilar biliary strictures undergoing palliative stent placements were prospectively reviewed. Extent of biliary drainage and type of stents used are: unilateral metallic stent placement in 19, unilateral plastic stent in 22, bilateral metallic stents in 21 and bilateral plastic stents in 30. Relatively small caliber stents were inserted in most patients undergoing bilateral drainage with plastic stents. Major cause of stent occlusion was: tumor ingrowth for metallic stents, and bile encrustation for plastic stents. Early and late cholangitis associated with stent occlusion was significantly frequent in patients undergoing bilateral plastic stent placement. Cholangitis was not observed in patients undergoing metallic stent placement. According to Kaplan-Meier method, bilateral metallic stents offered significantly longer patency, compared with the other three groups. There was no significant difference in the median length of survival between groups. Bilateral metallic stent placement may provide effective palliation in patients with hilar biliary strictures. Palliation with bilateral small plastic stents, due to their propensity to be easily occluded, may become less feasible.

    DOI: 10.11210/tando.22.160

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  • A prospective, single-blind trial comparing wireless capsule endoscopy and double-balloon enteroscopy in patients with obscure gastrointestinal bleeding.

    Kameda N, Higuchi K, Shiba M, Tanigawa T, Watanabe K, Watanabe T, Tominaga K, Fujiwara Y, Oshitani N, Arakawa T.

    J Gastroenterol.   43 ( 6 )   434 - 40   2008

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  • Management of gastric fundal varices without gastro-renal shunt in 15 patients.

    Kameda N, Higuchi K, Shiba M, Kadouchi K, Tominaga K, Fujiwara Y, Nakamura K, Arakawa T.

    World J Gastroenterol.   14 ( 3 )   448 - 53   2008

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  • Indomethacin may injure the small intestine through a toll-like receptor 4/MyD88-dependent pathway Reviewed

    Watanabe T., Fujiwara Y., Kobata A., Nishio H., Tanigawa T., Shiba M., Tominaga K., Oshitani N., Asahara T., Nomoto K., Takeuchi K., Higuchi K., Arakawa T.

    DIGESTION   77   63 - 64   2008( ISSN:0012-2823

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  • A prospective, single-blind trial comparing wireless capsule endoscopy and double-balloon enteroscopy in patients with obscure gastrointestinal bleeding Reviewed

    Kameda Natsuhiko, Higuchi Kazuhide, Shiba Masatsugu, Machida Hirohisa, Okazaki Hirotoshi, Yamagami Hirokazu, Tanigawa Tftsuya, Watanabe Kenji, Watanabe Toshio, Tominaga Kazunari, Fujiwara Yasuhiro, Oshitani Nobuhide, Arakawa Tetsuo

    JOURNAL OF GASTROENTEROLOGY   43 ( 6 )   434 - 440   2008( ISSN:0944-1174

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    DOI: 10.1007/s00535-008-2182-9

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  • Concurrent assessment of reservoir and emptying of the stomach for dyspepsia patients Reviewed

    Tominaga Kazunari, Higuchi Kazuhide, Ochi Masahiro, Kadouchi Kaori, Kawamura Etsushi, Tanigawa Tetsuya, Shiba Masatsugu, Watanabe Toshio, Fujiwara Yasuhiro, Shiomi Nobuhide Oshitani Susumu, Arakawa Tetsuo

    HEPATO-GASTROENTEROLOGY   55 ( 82-83 )   744 - 749   2008( ISSN:0172-6390

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  • Evaluation of Small Bowel Injury in Patients with Rheumatoid Arthritis by Capsule Endoscopy: Effects of Anti-Rheumatoid Arthritis Drugs Reviewed

    Sugimori Satoshi, Watanabe Toshio, Tabuchi Masahiko, Kameda Natsuhiko, Machida Hirohisa, Okazaki Hirotoshi, Tanigawa Tetsuya, Yamagami Hirokazu, Shiba Masatsugu, Watanabe Kenji, Tominaga Kazunari, Fujiwara Yasuhiro, Oshitani Nobuhide, Koike Tatsuya, Higuchi Kazuhide, Arakawa Tetsuo

    DIGESTION   78 ( 4 )   208 - 213   2008( ISSN:0012-2823

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    DOI: 10.1159/000190403

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  • Hyper susceptibility to indomethacin-induced gastric mucosal injury still persists after eradication of Helicobacter pylori - effect of prostaglandin E-2 and rebamipide Reviewed

    Tanicawa T., Watanabe T., Higuchi K., Taira K., Sasaki E., Shiba M., Tominaga K., Fujiwara Y., Shitani N., Arakawa T.

    DIGESTION   77   68 - 68   2008( ISSN:0012-2823

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  • Plummer-Vinson syndrome successfully treated by endoscopic dilatation Reviewed

    Enomoto Masaru, Kohmoto Madoka, Arafa Usama Ahmed, Shiba Masatsugu, Watanabe Toshio, Tominaga Kazunari, Fujiwara Yasuhiro, Saeki Yoshihiko, Higuchi Kazuhide, Nishiguchi Shuhei, Shiomi Susumu, Osugi Haruji, Kinoshita Hiroaki, Arakawa Tetsuo

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   22 ( 12 )   2348 - 2351   2007.12( ISSN:0815-9319

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    DOI: 10.1111/j.1440-1746.2006.03430.x

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  • Anti-inflammatory effects of pravastatin on Helicobacter pylori-induced gastritis in mice Reviewed

    Yamato Masanori, Watanabe Toshio, Higuchi Kazuhide, Taira Koichi, Tanigawa Tetsuya, Shiba Masatsugu, Tominaga Kazunari, Fujiwara Yasuhiro, Oshitani Nobuhide, Takeuchi Koji, Arakawa Tetsuo

    DIGESTIVE DISEASES AND SCIENCES   52 ( 10 )   2833 - 2839   2007.10( ISSN:0163-2116

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    DOI: 10.1007/s10620-006-9638-7

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  • [Clinical features of NSAID-induced small intestinal damage]. Reviewed

    Sugimori S, Watanabe T, Shiba M, Higuchi K, Arakawa T

    Nihon rinsho. Japanese journal of clinical medicine   65 ( 10 )   1862 - 5   2007.10( ISSN:0047-1852

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  • [The role of mucoprotective drugs in a treatment and prevention for NSAID-induced gastric ulcer]. Reviewed

    Okuyama M, Tominaga K, Tanigawa T, Shiba M, Watanabe T, Fujiwara Y, Oshitani N, Higuchi K, Arakawa T

    Nihon rinsho. Japanese journal of clinical medicine   65 ( 10 )   1850 - 5   2007.10( ISSN:0047-1852

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  • Primary duodenal lymphoma: successful rituximab treatment and evaluation by FDG-PET. Reviewed

    Tanaka F, Tominaga K, Ochi M, Yamada T, Sasaki E, Shiba M, Watanabe T, Fujiwara Y, Uchida T, Oshitani N, Higuchi K, Arakawa T

    Hepato-gastroenterology   54 ( 78 )   1658 - 61   2007.09( ISSN:0172-6390

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  • Primary duodenal lymphoma: Successful rituximab treatment and evaluation by FDG-PET Reviewed

    Tanaka Fumio, Tominaga Kazunari, Ochi Masahiro, Yamada Takao, Sasaki Eiji, Shiba Masatsugu, Watanabe Toshio, Fujiwara Yasuhiro, Uchida Toshiyuki, Oshitani Nobuhide, Higuchi Kazuhide, Arakawa Tetsuo

    HEPATO-GASTROENTEROLOGY   54 ( 78 )   1658 - 1661   2007.09( ISSN:0172-6390

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  • LAFUTIDINE PROMOTES HEALING OF GASTRIC ULCER IN STREPTOZOTOCIN-INDUCED DIABETIC RATS Reviewed

    TANIGAWA Tetsuya, WATANABE Toshio, OCHI Masahiro, TANAKA Fumio, SUGAWA Takashi, HAYAKAWA Tsuyoshi, SASAKI Eiji, SHIBA Masatsugu, TOMINAGA Kazunari, FUJIWARA Yasuhiro, OSHITANI Nobuhide, HIGUCHI Kazuhide, ARAKAWA Tetsuo

    34 ( 1 )   38 - 41   2007.05( ISSN:09163301

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  • Genetic and epigenetic markers to identify high risk patients for multiple early gastric cancers after treatment with endoscopic mucosal resection. Reviewed

    Fukuda M, Yokozaki H, Shiba M, Higuchi K, Arakawa T

    日本酸化ストレス学会 Journal of clinical biochemistry and nutrition   40 ( 3 )   203 - 9   2007.05( ISSN:0912-0009

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    The development of multiple gastric cancer is a major problem after the endoscopic resection of the first early gastric cancer. To find out markers to identify high risk patients, we analyzed the microsatellite instability (MSI) status and hypermethylation of tumor-related genes in multiple gastric cancers. Sixty-four adenocarcinomas resected by endoscopy, including 32 early solitary gastric cancers (SGCs) from 32 patients and 32 multiple gastric cancers (MGCs) from 14 patients, were employed. We analyzed MSI and the methylation status of promoter regions of the <i>hMLH1</i>, <i>MGMT</i>, <i>p16</i> and <i>E-cadherin</i> using methylation-specific Polymerase Chain Reaction. Expression levels of <i>hMLH1</i> were examined by immunohistochemistry. MSI (+) was detected in 5 of the 14 (35.7%) patients with MGCs, and in only 3 of the 32 patients (9.3%) with SGCs. Significant differences were observed between the 2 groups (<i>p</i><0.001). Hypermethylation of <i>hMLH1</i> was more frequently detected in MGCs than in SGCs (<i>p</i><0.01), whereas significant difference was not observed in the frequency of <i>MGMT</i>, <i>p16</i> or <i>E-cadherin</i> promoter methylation between the 2 groups. In conclusion, our results indicate that inactivation of <i>hMLH1</i> through promoter hypermethylation may be involved in the development of multiple gastric cancers following the MSI pathway.

    DOI: 10.3164/jcbn.40.203

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  • [Prevalence, diagnosis and treatment of extraesophageal manifestations of GERD]. Reviewed

    Sugawa T, Fujiwara Y, Okuyama M, Tanigawa T, Shiba M, Tominaga K, Watanabe T, Oshitani N, Higuchi K, Arakawa T

    Nihon rinsho. Japanese journal of clinical medicine   65 ( 5 )   946 - 50   2007.05( ISSN:0047-1852

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  • Genetic and epigenetic markers to identify high risk patients for multiple early gastric cancers after treatment with endoscopic mucosal resection Reviewed

    Fukuda Mayumi, Yokozaki Hiroshi, Shiba Masatsugu, Higuchi Kazuhide, Arakawa Tetsuo

    JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION   40 ( 3 )   203 - 209   2007.05( ISSN:0912-0009

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  • Four-year follow-up of the first case of gastroesophageal reflux disease treated with endoluminal gastroplication in Japan Reviewed

    HIGUCHI Kazuhide, SHIBA Masatsugu, OKAZAKI Hirotoshi, TABUCHI Masahiko, KAMEDA Natsuhiko, KADOUCHI Kaori, TOMINAGA Kazunari, WATANABE Toshio, FUJIWARA Yasuhiro, OSHITANI Nobuhide, ARAKAWA Tetsuo

    Journal of gastroenterology   42 ( 4 )   325 - 326   2007.04( ISSN:09441174

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  • Four-year follow-up of the first case of gastroesophageal reflux disease treated with endoluminal gastroplication in Japan Reviewed

    Higuchi Kazuhide, Shiba Masatsugu, Okazaki Hirotoshi, Tabuchi Masahiko, Kameda Natsuhiko, Kadouchi Kaori, Tominaga Kazunari, Watanabe Toshio, Fujiwara Yasuhiro, Oshitani Nobuhide, Arakawa Tetsuo

    JOURNAL OF GASTROENTEROLOGY   42 ( 4 )   325 - 326   2007.04( ISSN:0944-1174

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    DOI: 10.1007/s00535-007-2005-4

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  • A case of mucosa-associated lymphoid tissue lymphoma forming multiple lymphomatous polyposis in the small intestine. Reviewed

    Hirata N, Tominaga K, Ohta K, Kadouchi K, Okazaki H, Tanigawa T, Shiba M, Watanabe T, Fujiwara Y, Nakamura S, Oshitani N, Higuchi K, Arakawa T

    World journal of gastroenterology   13 ( 9 )   1453 - 7   2007.03( ISSN:1007-9327

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    DOI: 10.3748/wjg.v13.i9.1453

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  • A case of mucosa-associated lymphoid tissue lymphoma forming multiple lymphomatous polyposis in the small intestine Reviewed

    Hirata Naoto, Tominaga Kazunari, Ohta Kensuke, Kadouchi Kaori, Okazaki Hirotoshi, Tanigawa Tetsuya, Shiba Masatsugu, Watanabe Toshio, Fujiwara Yasuhiro, Nakamura Shiro, Oshitani Nobuhide, Higuchi Kazuhide, Arakawa Tetsuo

    WORLD JOURNAL OF GASTROENTEROLOGY   13 ( 9 )   1453 - 1457   2007.03( ISSN:1007-9327

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    Publishing type:Research paper (scientific journal)  

  • Feasibility, safety, and efficacy of the Stretta procedure in Japanese patients with gastroesophageal reflux disease: first report from Asia Reviewed

    Higuchi Kazuhide, Fujiwara Yasuhiro, Okazaki Hirotoshi, Tabuchi Masahiko, Kameda Natsuhiko, Kadouchi Kaori, Machida Hirohisa, Tanigawa Tetsuya, Shiba Masatsugu, Watanabe Toshio, Tominaga Kazunari, Oshitani Nobuhide, Arakawa Tetsuo

    JOURNAL OF GASTROENTEROLOGY   42 ( 3 )   205 - 210   2007.03( ISSN:0944-1174

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    DOI: 10.1007/s00535-006-1944-5

    PubMed

  • What are the risk factors for aggravation of esophageal varices in patients with hepatocellular carcinoma? Reviewed

    Kadouchi Kaori, Higuchi Kazuhide, Shiba Masatsugu, Okazaki Hirotoshi, Yamamori Kazuki, Sasaki Eiji, Tominaga Kazunari, Watanabe Toshio, Fujiwara Yasuhiro, Oshitani Nobuhide, Arakawa Tetsuo

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   22 ( 2 )   240 - 246   2007.02( ISSN:0815-9319

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    DOI: 10.1111/j.1440-1746.2006.04418.x

    PubMed

  • A diagnosis support system for capsule endoscopy.

    Yagi Y, Vu H, Echigo T, Sagawa R, Yagi K, Shiba M, Higuchi K, Arakawa T.

    Inflammopharmacology.   15 ( 2 )   78 - 83   2007

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  • Contraction detection in small bowel from an image sequence of wireless capsule endoscopy. Reviewed

    Vu H, Echigo T, Sagawa R, Yagi K, Shiba M, Higuchi K, Arakawa T, Yagi Y

    Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention   10 ( Pt 1 )   775 - 83   2007

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    DOI: 10.1007/978-3-540-75757-3_94

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  • Roles of ZO-1 and epidermal growth factor in esophageal epithelial defense against acid Reviewed

    Okuyama Masatsugu, Fujiwara Yasuhiro, Tanigawa Tetsuya, Watababe Kenji, Shiba Masatsugu, Tominaga Kazunari, Watanebe Toshio, Oshitani Nobuhide, Higuchi Kazuhide, Arakawa Tetsuo

    DIGESTION   75 ( 2-3 )   135 - 141   2007( ISSN:0012-2823

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    DOI: 10.1159/000106454

    PubMed

  • ENDOLUMINAL THERAPIES FOR REFLUX ESOPHAGITIS Reviewed

    HIGUCHI Kazuhide, OKAZAKI Hirotoshi, TABUCHI Masahiko, SHIBA Masatsugu, WATANABE Toshio, TOMINAGA Kazunari, FUJIWARA Yasuhiro, ARAKAWA Tetsuo

    Japan Gastroenterological Endoscopy Society, GASTROENTEROLOGICAL ENDOSCOPY   48 ( 12 )   2763 - 2771   2006.12( ISSN:03871207

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    Gastroesophageal reflux disease is a common medical condition that typically requires lifelong medical therapy or surgery for the management of patients with frequent symptoms. The standard of care for patients with GERD is to begin treatment with acid suppressants. Currently, three endoluminal therapies for GERD are approved for use in the western countries. Clinical trials have examined either an endoscopic suturing, injection intervention, or thermal approach in the area of the lower esophageal sphincter. They are found to be useful for the treatment of GERD. However, the reported follow-up periods are short. The risk/benefit profile must be carefully evaluated for each of these interventions for a long-term.

    DOI: 10.11280/gee1973b.48.2763

    CiNii Article

  • Interactions between the grading of gastric atrophy associated with Helicobacter pylori infection and the severity of clinical symptoms and delay in gastric emptying in patients with functional dyspepsia Reviewed

    Kadouchi K., Tominaga K., Ochi M., Kawamura E., Sasaki E., Shiba M., Watanabe T., Fujiwara Y., Oshitani N., Higuchi K., Shiomi S., Arakawa T.

    ALIMENTARY PHARMACOLOGY & THERAPEUTICS   24   49 - 57   2006.12( ISSN:0269-2813

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    DOI: 10.1111/j.1365-2036.2006.00025.x

  • Successful treatment of giant rectal varices by modified percutaneous transhepatic obliteration with sclerosant: Report of a case. Reviewed

    Okazaki H, Higuchi K, Shiba M, Nakamura S, Wada T, Yamamori K, Machida A, Kadouchi K, Tamori A, Tominaga K, Watanabe T, Fujiwara Y, Nakamura K, Arakawa T

    World journal of gastroenterology   12 ( 33 )   5408 - 11   2006.09( ISSN:1007-9327

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    DOI: 10.3748/wjg.v12.i33.5408

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  • Successful treatment of giant rectal varices by modified percutaneous transhepatic obliteration with sclerosant: Report of a case Reviewed

    Okazaki Hirotoshi, Higuchi Kazuhide, Shiba Masatsugu, Nakamura Shirou, Wada Tomoko, Yamamori Kazuki, Machida Ai, Kadouchi Kaori, Tamori Akihiro, Tominaga Kazunari, Watanabe Toshio, Fujiwara Yasuhiro, Nakamura Kenji, Arakawa Tetsuo

    WORLD JOURNAL OF GASTROENTEROLOGY   12 ( 33 )   5408 - 5411   2006.09( ISSN:1007-9327

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  • Production of reactive oxygen species in peripheral blood is increased in individuals with Helicobacter pylori infection and decreased after its eradication. Reviewed

    Mashimo M, Nishikawa M, Higuchi K, Hirose M, Wei Q, Haque A, Sasaki E, Shiba M, Tominaga K, Watanabe T, Fujiwara Y, Arakawa T, Inoue M

    Helicobacter   11 ( 4 )   266 - 71   2006.08( ISSN:1083-4389

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    DOI: 10.1111/j.1523-5378.2006.00410.x

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  • Production of reactive oxygen species in peripheral blood is increased in individuals with Helicobacter pylori infection and decreased after its eradication Reviewed

    Mashimo Masayuki, Nishikawa Manabu, Higuchi Kazuhide, Hirose Masaki, Wei Qian, Haque Anwarul, Sasaki Eiji, Shiba Masatsugu, Tominaga Kazunari, Watanabe Toshio, Fujiwara Yasuhiro, Arakawa Tetsuo, Inoue Masayasu

    HELICOBACTER   11 ( 4 )   266 - 271   2006.08( ISSN:1083-4389

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  • Rumination syndrome in an adult with normal intelligence Reviewed

    SUGAWA Takashi, FUJIWARA Yasuhiro, OKUYAMA Masatsugu, HAYAKAWA Tsuyoshi, YAMAGAMI Hirokazu, WATANABE Kenji, SASAKI Eiji, SHIBA Masatsugu, WATANABE Toshio, TOMINAGA Kazunari, OSHITANI Nobuhide, HIGUCHI Kazuhide, ARAKAWA Tetsuo

    The Japanese Society of Gastroenterology, Nippon Shokakibyo Gakkai Zasshi   103 ( 6 )   631 - 635   2006.06( ISSN:04466586

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    A 32-year-old woman visited our department because of repeated regurgitation of foodC and was diagnosed with rumination syndrome based on possession of symptoms typical for it. Although rumination syndrome is classified as a functional esophageal disorder according to the Rome II criteriaC it is not well known in JapanC and there have been no previous reports of it in an adult with normal intelligence. Since patients with rumination syndrome are often misdiagnosed and receive unnecessary treatmentC awareness of it by physicians is important.<br>

    DOI: 10.11405/nisshoshi.103.631

    CiNii Article

  • [Rumination syndrome in an adult with normal intelligence]. Reviewed

    Sugawa T, Fujiwara Y, Okuyama M, Hayakawa T, Yamagami H, Watanabe K, Sasaki E, Shiba M, Watanabe T, Tominaga K, Oshitani N, Higuchi K, Arakawa T

    Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology   103 ( 6 )   631 - 5   2006.06( ISSN:0446-6586

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  • Regression of primary low-grade mucosa-associated lymphoid tissue lymphoma of duodenum after long-term treatment with clarithromycin. Reviewed

    Ochi M, Tominaga K, Okazaki H, Yamamori K, Wada T, Shiba M, Sasaki E, Watanabe T, Fujiwara Y, Oshitani N, Higuchi K, Arakawa T

    Scandinavian journal of gastroenterology   41 ( 3 )   365 - 9   2006.03( ISSN:0036-5521

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    DOI: 10.1080/00365520500331224

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  • Regression of primary low-grade mucosa-associated lymphoid tissue lymphoma of duodenum after long-term treatment with clarithromycin Reviewed

    Ochi M, Tominaga K, Okazaki H, Yamamori K, Wada T, Shiba M, Sasaki E, Watanabe T, Fujiwara Y, Oshitani N, Higuchi K, Arakawa T

    SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY   41 ( 3 )   365 - 369   2006.03( ISSN:0036-5521

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  • Shrinkage Detection of Small Intestine from a Capsule Endoscope Reviewed

    UEDA Kensuke, ECHIGO Tomio, SAGAWA Ryusuke, MUKAIGAWA Yasuhiro, YAGI Keiko, SHIBA Masatsugu, HIGUCHI Kazuhide, ARAKAWA Tetsuo, YAGI Yasushi

    The Institute of Electronics, Information and Communication Engineers, IEICE technical report   105 ( 580 )   9 - 12   2006.01( ISSN:09135685

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    A capsule endoscope is getting attention for observing a small intestine which is hard to examine. The capsule swallowed by a patient moves in the peristaltic movement and takes images by an embedded camera. As the direction of the camera frequently changes, a surveyor sometimes cannot recognize which direction the camera looks toward. This paper describes an image display method by displaying the center position of shrinkage in the small intestine in the middle of the screen for its viewablity. Using low brightness area, edge elements and rugae of the small intestine as feature quantities, we classify the condition of the small intestine and estimate the center position of its shrinkage.

    CiNii Article

  • Video Display Control for a Capsule Endoscopy Reviewed

    HAI Vu, ECHIGO Tomio, SAGAWA Ryusuke, YAGI Keiko, SHIBA Masatsugu, HIGUCHI Kazuhide, ARAKAWA Tetsuo, YAGI Yasushi

    The Institute of Electronics, Information and Communication Engineers, IEICE technical report   105 ( 580 )   5 - 8   2006.01( ISSN:09135685

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    This paper presents a method for reducing diagnostic time by controlling frame rate adaptively in a capsule endoscopic image sequence captured during 8 hours. Depending on the skill, it requires from 45 minutes to two hours to evaluate the video sequence under extreme concentration of medical doctors. The video sequence would be played at high speed at stable regions to save time and the speed would be decreased at rough changing that can help suspicious findings more conveniently. The capturing conditions are classified into groups corresponding to changing levels between two frames. The delay time of these frames was calculated by the parametric function. The optimal parameter set is determined from evaluations by medical doctors. In conclusion, the average diagnostic time can be reduced from 8 hours down to around 30 minutes.

    CiNii Article

  • Risk factors for bleeding after endoscopic mucosal resection. Reviewed

    Shiba M, Higuchi K, Kadouchi K, Montani A, Yamamori K, Okazaki H, Taguchi M, Wada T, Itani A, Watanabe T, Tominaga K, Fujiwara Y, Hayashi T, Tsumura K, Arakawa T

    World journal of gastroenterology   11 ( 46 )   7335 - 9   2005.12( ISSN:1007-9327

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    DOI: 10.3748/wjg.v11.i46.7335

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  • Risk factors for bleeding after endoscopic mucosal resection Reviewed

    Shiba Masatsugu, Higuchi Kazuhide, Kadouchi Kaori, Montani Ai, Yamamori Kazuki, Okazaki Hirotoshi, Taguchi Makiko, Wada Tomoko, Itani Atsushi, Watanabe Toshio, Tominaga Kazunari, Fujiwara Yoshihiro, Hayashi Tomoshige, Tsumura Kei, Arakawa Tetsuo

    WORLD JOURNAL OF GASTROENTEROLOGY   11 ( 46 )   7335 - 7339   2005.12( ISSN:1007-9327

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  • Association between dinner-to-bed time and gastro-esophageal reflux disease Reviewed

    Fujiwara Y, Machida A, Watanabe Y, Shiba M, Tominaga K, Watanabe T, Oshitani N, Higuchi K, Arakawa T

    AMERICAN JOURNAL OF GASTROENTEROLOGY   100 ( 12 )   2633 - 2636   2005.12( ISSN:0002-9270

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    DOI: 10.1111/j.1572-0241.2005.00354.x

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  • Association of psychological factors with the pathophysiology of functional dyspepsia Reviewed

    TOMINAGA Kazunari, HIGUCHI Kazuhide, IKETANI Toshiya, OCHI Masahiro, KADOUCHI Kaori, SASAKI Eiji, SHIBA Masatsugu, WATANABE Toshio, FUJIWARA Yasuhiro, OSHITANI Nobuhide, NAGATA Toshihiko, KIRIIKE Nobuo, ARAKAWA Tetsuo

    9 ( 4 )   200 - 204   2005.11( ISSN:13429558

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    CiNii Article

  • Rebamipide reduces delay in gastric ulcer healing in cyclooxygenase-2-deficient mice Reviewed

    Watanabe T, Higuchi K, Taira K, Sasaki E, Shiba M, Tominaga K, Fujiwara Y, Oshitani N, Arakawa T

    DIGESTIVE DISEASES AND SCIENCES   50   S63 - S69   2005.10( ISSN:0163-2116

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    DOI: 10.1007/s10620-005-2808-1

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  • COVERED WALLSTENT FOR PALLIATION OF MALIGNANT COMMON BILE DUCT STRICTURE : PROSPECTIVE MULTICENTER EVALUATION Reviewed

    KUBOTA YOSHITSUGU, MUKAI HIDEKAZU, NAKAIZUMI AKIHIKO, TANAKA KIYOHITO, OKABE YOSHIHIRO, SAKAGAMI TAKASHI, KITANO MASAYUKI, MITSUFUJI SHOJI, SHIRASAKA DAISUKE, KIKUCHI EIRYO, KOYAMA SHIGEKI, YAZUMI SHUJIRO, SHIBA MASATSUGU, YASUDA KENJIRO

    Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society   17 ( 3 )   218 - 223   2005.07( ISSN:09155635

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    CiNii Article

  • Differences in clinical characteristics between patients with endoscopy-negative reflux disease and erosive esophagitis in Japan Reviewed

    Fujiwara Y, Higuchi K, Shiba M, Yamamori K, Watanabe Y, Sasaki E, Tominaga K, Watanabe T, Oshitani N, Arakawa T

    AMERICAN JOURNAL OF GASTROENTEROLOGY   100 ( 4 )   754 - 758   2005.04( ISSN:0002-9270

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    DOI: 10.1111/j.1572-0241.2005.40966.x

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  • Successful Treatment with Cyclophosphamide Pulse Therapy in a Case of Autoimmune Protein-losing Enteropaty Reviewed

    HOTTA Kiyoshi, FUJIWARA Yasuhiro, YAMAMORI Kazuki, ITANI Atushi, SASAKI Eiji, WATANABE Kenji, SHIBA Masatsugu, TOMINAGA Kazunari, WATANABE Toshio, NAKAMURA Shiro, OSHITANI Nobuhide, HIGUCHI Kazuhide, ARAKAWA Tetsuo

    47 ( 2 )   200 - 205   2005.02( ISSN:03871207

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    CiNii Article

  • Prevalence of gastroesophageal reflux disease and gastroesophageal reflux disease symptoms in Japan Reviewed

    Fujiwara Y, Higuchi K, Watanabe Y, Shiba M, Watanabe T, Tominaga K, Oshitani N, Matsumoto T, Nishikawa H, Arakawa T

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   20 ( 1 )   26 - 29   2005.01( ISSN:0815-9319

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    DOI: 10.1111/j.1440-1746.2004.03521.x

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  • SUCCESSFUL TREATMENT WITH CYCLOPHOSPHAMIDE PULSE THERAPY IN A CASE OF AUTOIMMUNE PROTEIN-LOSING ENTEROPATY Reviewed

    HOTTA Kiyoshi, NAKAMURA Shiro, OSHITANI Nobuhide, HIGUCHI Kazuhide, ARAKAWA Tetsuo, FUJIWARA Yasuhiro, YAMAMORI Kazuki, ITANI Atushi, SASAKI Fiji, WATANABE Kenji, SHIBA Masatsugu, TOMINAGA Kazunari, WATANABE Toshio

    Japan Gastroenterological Endoscopy Society, GASTROENTEROLOGICAL ENDOSCOPY   47 ( 2 )   200 - 205   2005( ISSN:0387-1207

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    A 41-year-old man was admitted to our hospital because of face and leg edema. Blood examination revealed hypoalbuminemia and positive reaction for anti-nuclear antibodies and anti-Sm antibodies. Abdominal scintigram using 99mTc-labeled human albumin revealed abnormal radioactivity in the ascending and transverse colon, suggesting albumin losing from terminal ileum or ascending colon. Colonoscopy revealed slight reddish mucosa and histology of biopsy specimen showed mild edema and inflammatory cell infiltration. Immunofluorescense study revealed deposition of C3 in the endothelium of colonic mucosa. Diagnosis of autoimmune protein-losing enteropathy was made. Steroid therapy was not effective and cyclophosphamide pulse therapy resulted in a significant recovery of serum albumin level and improvement of clinical symptoms.

    DOI: 10.11280/gee1973b.47.200

    CiNii Article

  • Risk factors for bleeding after endoscopic mucosal resection.

    Shiba M, Higuchi K, Watanabe T, Tominaga K, Fujiwara Y, Hayashi T, Tsumura K, Arakawa T.

    World J Gastroenterol.   11 ( 46 )   7335 - 9   2005

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  • Effects of ranitidine on quality of gastric ulcer healing compared with famotidine: A randomized, controlled, multicenter trial Reviewed

    Higuchi K, Watanabe T, Tominaga K, Shiba M, Nakagawa K, Uno H, Kitada K, Satoh H, Chono S, Uchida T, Fujiwara Y, Arakawa T

    INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY RESEARCH   25 ( 4 )   187 - 194   2005( ISSN:0251-1649

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  • Efficacy and safety of balloon-occluded endoscopic injection sclerotherapy as a prophylactic treatment for high-risk gastric fundal varices: a prospective, randomized, comparative clinical trial.

    Shiba M, Higuchi K, Nakamura K, Itani A, Kuga T, Okazaki H, Fujiwara Y, Arakawa T

    Gastrointest Endosc.   56 ( 4 )   522 - 8   2002

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  • Risk associated with reprocessed reusable endoscopic instruments.

    Shiba M, Higuchi K, Fujiwara Y, Tominaga K, Watanabe T, Itani A, Oshitani N, Matsumoto T, Arakawa T.

    Am J Gastroenterol.   96 ( 12 )   3465 - 7   2001

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MISC

  • 【大腸腫瘍の内視鏡治療戦略-攻めるか、引くか?】早期癌の治療方針 リンパ節転移リスクのうち、浸潤距離以外の因子がマイナスであれば、経過観察をすすめる No Reviewed

    福永 周生, 永見 康明, 片之坂 友喜, 丸山 紘嗣, 大南 雅揮, 平良 高一, 谷川 徹也, 斯波 将次, 渡辺 俊雄, 藤原 靖弘

    (株)東京医学社 消化器内視鏡   31 ( 10 )   1556 - 1561   2019.10( ISSN:0915-3217

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  • 【高齢化時代の薬剤起因性消化管傷害-NSAIDs/抗血栓薬への対策-】薬剤起因性小腸傷害の病態と臨床像 Reviewed

    谷川 徹也, 渡辺 俊雄, 斯波 将次, 灘谷 祐二, 永見 康明, 杉森 聖司, 山上 博一, 富永 和作, 藤原 靖弘, 荒川 哲男, 小池 達也

    (株)ヴァンメディカル 消化器の臨床   17 ( 6 )   551 - 555   2014.12( ISSN:1344-3070

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    高齢化時代を迎え、変形性膝関節症や腰痛症、腰椎圧迫骨折といった加齢に関連した疾患を有する高齢者は本邦でも年々増加の一途をたどっている。これらの整形外科的疾患に対しては疼痛の緩和のために非ステロイド系抗炎症薬(NSAIDs)が処方される。また、人口の高齢化が急速に進行しているわが国では抗血小板薬としての低用量アスピリンの使用量が増加している。しかしながら、これらの薬剤の合併症として消化管粘膜傷害が問題となる。NSAIDs起因性小腸傷害に関しての有効な予防手段についてはいまだ確立したものはなく、その病態と臨床像を解明し予防手段を確立することは重要な研究課題となっている。(著者抄録)

  • ESDの実際 大型Is病変に対するESDの実際 Reviewed

    福永 周生, 永見 康明, 斯波 将次, 南野 弘明, 大南 雅揮, 杉森 聖司, 谷川 徹也, 山上 博一, 渡辺 俊雄, 富永 和作, 藤原 靖弘, 荒川 哲男

    (株)ヴァンメディカル 消化器の臨床   17 ( 6 )   591 - 596   2014.12( ISSN:1344-3070

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    大きな丈の高い隆起成分を有する大腸腫瘍(大型Is病変)に対するESDでは、粘膜下層剥離時に高度の線維化に遭遇しやすく、しばしば病変の展開や剥離ラインの想定に難渋する。早めに粘膜下層深層にアプローチし、線維化と筋層を判別して線維化が高度な部分をアイソレートする。デバイスや手技を工夫しても、線維化を突破できない場合は中止を決断する。大型Is病変のESDは熟練医が行うべきであるが、手技時間は長く術者の負担は大きい。特に結腸においては中止例も多く、外科的切除も視野に入れるべきである。(著者抄録)

  • 【食道病変!これ1冊】平坦な病変 びらん様所見を呈するもの 良性 薬剤性食道炎 Reviewed

    鋳谷 成弘, 斯波 将次, 荒川 哲男

    (株)東京医学社 消化器内視鏡   26 ( 10 )   1656 - 1657   2014.10( ISSN:0915-3217

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  • 診断講座 症例から学ぶIBD鑑別診断のコツ(第23回) 腸結核 Reviewed

    山上 博一, 渡部 公彦, 細見 周平, 野口 篤志, 湯川 知洋, 田中 史生, 鎌田 紀子, 谷川 徹也, 斯波 将次, 渡辺 俊雄, 富永 和作, 藤原 靖弘, 荒川 哲男

    (株)先端医学社 IBD Research   8 ( 3 )   202 - 206   2014.09( ISSN:1881-6533

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    結核は過去の疾患と思われがちであるが、わが国はいまだ結核の中蔓延国である。結核の病変部位はおもに肺であるが小腸、大腸を病変とすることもあり、結核を増悪させる抗TNFα抗体治療などがおこなわれるクローン病との鑑別は重要である。腸結核の内視鏡像は輪状潰瘍、横走する潰瘍が特徴的とされているが多彩な病変を呈する。診断には病変部位における結核菌の存在を証明することが重要であるが、結核感染に特徴的な肉芽腫の証明や補助診断としてインターフェロンγ遊離試験(interferon-γ release assay:IGRA)なども参考にする。(著者抄録)

  • 【炎症性腸疾患診療の新たな展開】潰瘍性大腸炎 内視鏡診断 Reviewed

    山上 博一, 細見 周平, 野口 篤志, 湯川 知洋, 田中 史生, 鎌田 紀子, 谷川 徹也, 斯波 将次, 渡辺 俊雄, 富永 和作, 藤原 靖弘, 荒川 哲男

    大道学館出版部 臨牀と研究   91 ( 8 )   1008 - 1011   2014.08( ISSN:0021-4965

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  • 【機能性ディスペプシア(FD)診療のこれから】Rome III基準と日本人のFDの特徴 Reviewed

    富永 和作, 藤川 佳子, 田中 史生, 谷川 徹也, 斯波 将次, 渡辺 俊雄, 藤原 靖弘, 荒川 哲男

    (一財)日本消化器病学会 日本消化器病学会雑誌   111 ( 6 )   1079 - 1087   2014.06( ISSN:0446-6586

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    機能性ディスペプシア(FD)の認知度が高まり、2013年3月には本邦で保険病名として収載されることにもなった。しかし、FDに対する定義・診断にいたっては、2006年に出されたRome III基準に準拠している現状がある。Rome III基準が、日本人に適した基準、日本の保険制度に適した基準であるかについて疑問視される状況の中で、本邦におけるFD診療ガイドラインも2014年に提唱されている。このような現状において、日本人FDの特徴について改めて振り返り、日本の医療現場におけるRome III基準の適性について検証する時期に来ているのかもしれない。本稿ではこれらの点について概説することにする。(著者抄録)

  • 【ここまで来た、炎症性腸疾患の新展開】炎症性腸疾患(IBD) ダブルバルーン内視鏡 Reviewed

    山上 博一, 萩原 良恵, 森本 謙一, 細見 周平, 野口 篤志, 湯川 知洋, 宮嵜 孝子, 鎌田 紀子, 十河 光栄, 谷川 徹也, 斯波 将次, 渡辺 憲治, 渡辺 俊雄, 富永 和作, 藤原 靖弘, 荒川 哲男

    (株)東京医学社 成人病と生活習慣病   44 ( 3 )   285 - 288   2014.03( ISSN:1347-0418

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    ダブルバルーン内視鏡検査(DBE)の開発・普及により、小腸粘膜の内視鏡観察が以前と比べて容易になった。Crohn病の好発部位は回腸末端であるが、回腸末端に炎症を認めない患者でも近位側の回腸に炎症を認める場合がしばしば経験される。DBEはCrohn病の微小な小腸病変でも観察でき、内視鏡下生検により肉芽腫を証明することでもCrohn病診断に寄与できる。DBEではカプセル内視鏡と違い滞留の懸念がない。Crohn病患者におけるDBEでは特に消化管穿孔に注意を要する。(著者抄録)

  • 【PPI抵抗性GERDに対する診療の現状】PPI抵抗性GERDに使用される薬剤の特徴と使用上の注意 漢方薬 Reviewed

    富永 和作, 藤川 佳子, 田中 史生, 谷川 徹也, 山上 博一, 斯波 将次, 渡辺 憲治, 渡辺 俊雄, 藤原 靖弘, 荒川 哲男

    (株)自然科学社 医学と薬学   71 ( 4 )   575 - 584   2014.03( ISSN:0389-3898

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  • 【機能性消化器疾患-あたらしい診療戦略】治療薬解説 FGIDに用いる消化管運動調整薬の薬効および作用機序 Reviewed

    中原 憲一, 富永 和作, 十河 光栄, 山上 博一, 谷川 徹也, 斯波 将次, 渡辺 憲治, 渡辺 俊雄, 藤原 靖弘, 荒川 哲男

    (株)ライフメディコム カレントテラピー   31 ( 12 )   1273 - 1277   2013.12( ISSN:0287-8445

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  • 【機能性ディスペプシア(FD)診療の新潮流】FDの病態・症状と酸分泌抑制薬を使いこなすためのコツ Reviewed

    富永 和作, 藤川 佳子, 田中 史生, 谷川 徹也, 斯波 将次, 渡辺 俊雄, 藤原 靖弘, 荒川 哲男

    (株)ヴァンメディカル 消化器の臨床   16 ( 6 )   596 - 602   2013.12( ISSN:1344-3070

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    機能性ディスペプシア(FD)の病態が多岐にわたり複雑に関与していることは周知である。個々のFD患者において、上部消化管内視鏡検査を含めた種々検査での所見が類似したものであるため、個別の病態としての関与や治療選択を行う判断基準が、患者からの症状を中心としたものとなることも事実である。したがって、酸分泌抑制薬を使用するに際して、目の前にいる患者が訴えるディスペプシア症状と胃酸分泌が関連していることを適切に判断(診断)することが理想的となる。その診断をすることが、酸分泌抑制薬を使いこなすためのコツであり、このコツを会得することは重要であるがなかなか困難なようである。(著者抄録)

  • 【消化器感染症-慢性炎症-消化器機能障害、この三角関係をみつめる】感染症は食道運動異常の原因となるか Reviewed

    藤原 靖弘, 木幡 幸恵, 十河 光栄, 谷川 徹也, 山上 博一, 斯波 将次, 渡辺 憲治, 富永 和作, 渡辺 俊雄, 荒川 哲男

    (株)先端医学社 分子消化器病   10 ( 3 )   219 - 223   2013.09( ISSN:1348-995X

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    食道運動異常の代表的疾患である食道アカラシアについて、ウイルス感染の観点から病態機序を総説した。主病態はアウエルバッハ筋間神経叢における一酸化窒素(NO)および血管作動性腸管ペプチド(VIP)を神経伝達物質とする抑制性運動神経節細胞の変性・消失による下部食道括約筋弛緩不全である。血清抗体価や局所PCRによるウイルス感染の関与については議論が多い。一方、下部食道括約筋局所におけるCD3+CD8+T細胞の有意な浸潤、T細胞受容体(TCR)解析による特異的抗原存在の示唆、HSV-1刺激によるリンパ球増殖亢進やTh1サイトカイン分泌増加が認められることから、ウイルス感染の慢性炎症による特異的な免疫反応が病態の一因として示唆されている。(著者抄録)

  • 【治療に直結する大腸腫瘍診断のストラテジー】大腸LSTの治療法選択に直結する診断のストラテジー 20mm以上のLST-Gにおける臨床病理学的特徴と治療法の選択 通常診断重視の立場から Reviewed

    福永 周生, 町田 浩久, 斯波 将次, 大南 雅揮, 永見 康明, 杉森 聖司, 十河 光栄, 谷川 徹也, 山上 博一, 渡辺 憲治, 渡辺 俊雄, 富永 和作, 藤原 靖弘, 荒川 哲男

    (株)東京医学社 消化器内視鏡   25 ( 8 )   1235 - 1243   2013.08( ISSN:0915-3217

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    LST-Gに対する適切な治療方針を模索するため、内視鏡的に一括切除が困難となりうる20mm以上のLST-G 136病変の臨床病理学的特徴を検討した。平均腫瘍径は36mm、盲腸、上行結腸、直腸で72%を占め、担癌率は72%、SM浸潤率は9%であった。136病変をLST-G(Uni)38病変とLST-G(Mix)98病変に分けると、LST-G(Uni)ではSM浸潤癌はSM1の1例のみ(3%)で、LST-G(Mix)では30mm以上でのSM浸潤率は15%となった。色素拡大観察が可能であった病変では、SM1の8病変はIIIL型が1例のみで、その他はVI型軽度不整を呈した。SM2の4病変はすべてV型を呈し、VI型軽度不整が1例、VI型高度不整が3例であった。LST-G(Mix)のSM浸潤様式は、粗大結節直下のSM浸潤が7病変(64%)で、3病変がSM2であった。粗大結節直下以外の浸潤は4病変(36%)、1病変がSM2で、内訳は、粗大結節の辺縁部(立ち上がり部)が3例、粗大結節から離れた辺縁部が1例であった。以上より、EPMRでSM浸潤部位が分断される危険性が否めない病変は、30mm以上のLST-G(Mix)と考えられた。これらには一括切除による詳細な病理組織学的評価が必要と思われた。(著者抄録)

  • 【抗血栓薬/NSAIDsと消化管障害-その実態と最新のマネージメントに迫る-】抗血栓薬/NSAIDsによる消化管障害とそのマネージメント 抗潰瘍薬による薬剤性消化管傷害の予防・治療戦略 Reviewed

    渡辺 俊雄, 谷川 徹也, 灘谷 祐二, 山上 博一, 斯波 将次, 渡辺 憲治, 富永 和作, 藤原 靖弘, 荒川 哲男

    (株)ヴァンメディカル 消化器の臨床   16 ( 2 )   176 - 180   2013.04( ISSN:1344-3070

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    低用量アスピリンならびにNSAIDsによる消化管傷害に対する予防・治療の主流はプロトンポンプ阻害剤(PPI)である。しかし、最近大きな注目を集めている薬剤性小腸傷害に対しては、PPIは無効である。現時点で本傷害に対して有効性が確認されている薬剤はプロスタグランジン製剤のミソプロストールや粘膜防御因子増強薬のレバミピド、あるいはプロバイオティクスなどの数種の薬剤に限られる。このような臨床的背景のもと、消化管のトータルマネージメントを考慮した薬剤性消化管傷害に対する新たな予防・治療戦略の確立が求められている。(著者抄録)

  • 【消化管疾患に対する漢方医学からのアプローチ-現状と展望】消化管疾患に対する漢方医療の実際 慢性胃炎 Reviewed

    富永 和作, 谷川 徹也, 斯波 将次, 渡辺 俊雄, 藤原 靖弘, 荒川 哲男

    (株)日本メディカルセンター 臨床消化器内科   28 ( 2 )   169 - 176   2013.01( ISSN:0911-601X

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    漢方薬を用いた薬物療法は,日本においては西洋医学と東洋医学の融合による医療として提供できるという点において特徴的である.日常診療の現場において,種々の疾患や症状に対応すべく多数の漢方薬が処方され,内科,外科を含めたほぼすべての臨床領域において使用されているといっても過言ではない.消化器疾患のなかでも,慢性胃炎はもっともありふれた疾患の一つと考えられ,多くの薬剤が汎用される.漢方薬を用いたアプローチもその例外ではなく,古くからなされてきた.漢方薬を用いた慢性胃炎へのアプローチの現状,その有効性,作用機序などについて,現在までに集積されてきた知見について概説する.(著者抄録)

  • 【機能性消化管障害(FGID):診断と治療の進歩】最近の話題 今後期待される薬物療法 Reviewed

    富永 和作, 藤川 佳子, 田中 史生, 十河 光栄, 山上 博一, 谷川 徹也, 斯波 将次, 渡辺 憲治, 渡辺 俊雄, 藤原 靖弘, 荒川 哲男

    (一社)日本内科学会 日本内科学会雑誌   102 ( 1 )   96 - 104   2013.01( ISSN:0021-5384

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  • 【高齢者の機能性消化器疾患】高齢者における知覚異常と機能性消化器疾患の関連 Reviewed

    富永 和作, 藤川 佳子, 田中 史生, 十河 光栄, 山上 博一, 谷川 徹也, 斯波 将次, 渡辺 憲治, 渡辺 俊雄, 藤原 靖弘, 荒川 哲男

    (株)ライフ・サイエンス Geriatric Medicine   50 ( 8 )   911 - 918   2012.08( ISSN:0387-1088

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    機能性消化器疾患とは、機能性ディスペプシア(functional dyspepsia:FD)や過敏性腸症候群(Irritable bowel syndrome:IBS)に代表されるように、明らかな組織傷害が認められないにもかかわらず消化器関連症状を有する疾患群であり、その病態生理として知覚異常、なかでも内臓知覚過敏が関与することが知られている。高齢者と知覚との関連性について考えてみると、加齢に伴う変化として知覚異常が出現するか、出現するならば知覚過敏か知覚鈍麻かという2点が焦点となる。知覚の中でも内臓知覚に関しては、その詳細機序が最近になりようやく解明されつつあり、機能性消化器疾患との関連性についても言及されるようになってきたところである。しかし、加齢に伴い内臓知覚での変化(異常)が出現し、さらには機能性消化器疾患の病態にまで関与してくるか否かについては未だ不明な点が多い。(著者抄録)

  • 【肝・胆道系症候群(第2版) その他の肝・胆道系疾患を含めて 肝外胆道編】胆嚢 腫瘍、隆起性病変 胆嚢多形性巨大組織腺癌 Reviewed

    根引 浩子, 山崎 智朗, 斯波 将次, 坂口 浩樹

    (株)日本臨床社 日本臨床   別冊 ( 肝・胆道系症候群III )   334 - 336   2011.02( ISSN:0047-1852

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  • 第18回 消化器診療勉強会

    Role(s): Lecturer

    関西文化サロン  2013.04

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    Type:Lecture

    Number of participants:120(人)