Updated on 2024/03/15

写真a

 
KAWAGUCHI Tomoya
 
Organization
Graduate School of Medicine Department of Clinical Medical Science Professor
School of Medicine Department of Medical Science
Title
Professor
Affiliation
Institute of Medicine
Affiliation campus
Abeno Campus

Position

  • Graduate School of Medicine Department of Clinical Medical Science 

    Professor  2022.04 - Now

  • School of Medicine Department of Medical Science 

    Professor  2022.04 - Now

Degree

  • Ph.D in Medicine ( Osaka City University )

Research Areas

  • Life Science / Respiratory medicine  / respiratoty medicine

Research Interests

  • respiratory medicine, medical oncology, chemotherapy

Research Career

  • 肺癌の病因と病態についての研究。肺癌の治療開発。

    肺癌、化学療法、分子疫学  Joint Research in Organization

    1900.04 

Awards

  • 大阪市立大学医学部長賞優秀賞

    2017.03  

  • 平成27年度国立病院機構優秀論文賞最優秀賞

    2015  

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    Country:Japan

  • 大阪から肺がんをなくす会より表彰

    2011  

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    Country:Japan

Education

  • Osaka City University     Graduated/Completed

    1982.04 - 1988.03

Papers

  • Lack of Association Between Immunotherapy and Improvement of Survival for Non-small Cell Lung Cancer Patients With Hemodialysis: A Nationwide Retrospective Cohort Study.

    Sawa K, Ihara Y, Imai T, Sugimoto A, Nagamine H, Ogawa K, Nakahama K, Matsumoto Y, Tani Y, Kaneda H, Mitsuoka S, Kawaguchi T, Shintani A

    Clinical lung cancer   25 ( 2 )   144 - 150.e3   2024.03( ISSN:1525-7304

  • Efficacy of Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitors in Metastatic Non-Small Cell Lung Cancer Patients with Poor Performance Status and Epidermal Growth Factor Receptor Mutations: Findings from the Japanese Lung Cancer Registry Database.

    Okuma Y, Shintani Y, Sekine I, Shukuya T, Takayama K, Inoue A, Okamoto I, Kiura K, Yamamoto N, Kawaguchi T, Miyaoka E, Yoshino I, Date H

    Clinical lung cancer   2024.02( ISSN:1525-7304

  • Comparison of the specimen quality of endobronchial ultrasound-guided intranodal forceps biopsy using standard-sized forceps versus mini forceps for lung cancer: A prospective study.

    Nakai T, Matsumoto Y, Ueda T, Kuwae Y, Tanaka S, Miyamoto A, Matsumoto Y, Sawa K, Sato K, Yamada K, Watanabe T, Asai K, Furuse H, Uchimura K, Imabayashi T, Uenishi R, Fukui M, Tanaka H, Ohsawa M, Kawaguchi T, Tsuchida T

    Respirology (Carlton, Vic.)   2024.01( ISSN:1323-7799

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  • Tract creation with a 25-gauge needle for convex endobronchial ultrasound-guided core biopsy in intrapulmonary lesions adjacent to bronchi: three case reports.

    Nagamine H, Nakai T, Ueda T, Nakahama K, Sawa K, Yamada K, Watanabe T, Aasai K, Kawaguchi T

    Translational lung cancer research   12 ( 12 )   2550 - 2557   2023.12( ISSN:2218-6751

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  • Clinical significance of KL-6 in immune-checkpoint inhibitor treatment for non-small cell lung cancer.

    Nakahama K, Izumi M, Yoshimoto N, Fukui M, Sugimoto A, Nagamine H, Ogawa K, Sawa K, Tani Y, Kaneda H, Mitsuoka S, Watanabe T, Asai K, Kawaguchi T

    Cancer chemotherapy and pharmacology   92 ( 5 )   381 - 390   2023.11( ISSN:0344-5704

  • A Case of Successful Removal of a Foreign Body Located in the Peripheral Airway Using Flexible Bronchoscopy with Virtual Bronchoscopy Navigation

    Hikiishi Atsuhito, Nakai Toshiyuki, Matsui Erika, Yamane Kenshi, Sato Kanako, Watanabe Tetsuya, Asai Kazuhisa, Eguchi Yosuke, Kawaguchi Tomoya

    Internal Medicine   advpub ( 0 )   2023.10( ISSN:0918-2918 ( eISSN:13497235

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    <p>A case in which a foreign body located in the peripheral airway of the lung was removed by flexible bronchoscopy using a virtual bronchoscopy navigation (VBN) system has been reported. The patient was a 60-year-old man. Chest radiography revealed an incidental foreign body in the left lower lung. Chest computed tomography with 1.0-mm slices was used to create a VBN system and confirm the foreign body in left B<sup>9</sup>biiαy, which was removed by flexible bronchoscopy. Thus, peripheral foreign bodies can be safely removed using flexible bronchoscopy by creating a VBN system in advance. </p>

    DOI: 10.2169/internalmedicine.2072-23

    PubMed

  • RBM17 Expression Is Associated With the Efficacy of ICI Monotherapy in NSCLC With Low PD-L1 Expression.

    Nagamine H, Yashiro M, Yoshimoto N, Izumi M, Sugimoto A, Nakahama K, Ogawa K, Matsumoto Y, Sawa K, Tani Y, Kaneda H, Mitsuoka S, Yamada K, Watanabe T, Aasai K, Fukumura K, Mayeda A, Kawaguchi T

    Anticancer research   43 ( 10 )   4663 - 4672   2023.10( ISSN:0250-7005

  • Distinct contributions of muscle mass and strength stratified by nutritional status to physical activity in patients with chronic obstructive pulmonary disease(タイトル和訳中)

    Kawai Takahiro, Asai Kazuhisa, Miyamoto Atsushi, Yamada Kazuhiro, Furukawa Yuichiro, Toyokura Erika, Nishimura Misako, Sato Kanako, Watanabe Tetsuya, Kawaguchi Tomoya

    Respiratory Investigation   61 ( 4 )   389 - 397   2023.07( ISSN:2212-5345

  • Ethnic differences in lung cancer: "we can differ and still unite around common goals.".

    Kawaguchi T

    Respiratory investigation   61 ( 3 )   355 - 356   2023.05( ISSN:2212-5345

  • Influence of Smoking History on the Effectiveness of Immune-checkpoint Inhibitor Therapy for Non-small Cell Lung Cancer: Analysis of Real-world Data.

    Nakahama K, Izumi M, Yoshimoto N, Fukui M, Sugimoto A, Nagamine H, Ogawa K, Sawa K, Tani Y, Kaneda H, Mitsuoka S, Watanabe T, Asai K, Kawaguchi T

    Anticancer research   43 ( 5 )   2185 - 2197   2023.05( ISSN:0250-7005

  • Distinct contributions of muscle mass and strength stratified by nutritional status to physical activity in patients with chronic obstructive pulmonary disease.

    Kawai T, Asai K, Miyamoto A, Yamada K, Furukawa Y, Toyokura E, Nishimura M, Sato K, Watanabe T, Kawaguchi T

    Respiratory investigation   61 ( 4 )   389 - 397   2023.04( ISSN:2212-5345

  • A Large-Scale Prospective Concordance Study of Plasma- and Tissue-Based Next-Generation Targeted Sequencing for Advanced Non-Small Cell Lung Cancer (LC-SCRUM-Liquid).

    Sugimoto A, Matsumoto S, Udagawa H, Itotani R, Usui Y, Umemura S, Nishino K, Nakachi I, Kuyama S, Daga H, Hara S, Miyamoto S, Kato T, Sakakibara-Konishi J, Tabata E, Nakagawa T, Kawaguchi T, Sakai T, Shibata Y, Izumi H, Nosaki K, Zenke Y, Yoh K, Goto K

    Clinical cancer research : an official journal of the American Association for Cancer Research   29 ( 8 )   1506 - 1514   2023.04( ISSN:1078-0432

  • Vimentin expression correlates with immune-checkpoint inhibitor efficacy in non-small cell lung cancer.

    Nakahama K, Izumi M, Yoshimoto N, Fukui M, Sugimoto A, Nagamine H, Ogawa K, Sawa K, Tani Y, Kaneda H, Mitsuoka S, Watanabe T, Asai K, Kawaguchi T

    Cancer   2023.04( ISSN:0008-543X

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  • Epidemiology, risk factors and impact of cachexia on patient outcome: Results from the Japanese Lung Cancer Registry Study.

    Shukuya T, Takahashi K, Shintani Y, Miura K, Sekine I, Takayama K, Inoue A, Okamoto I, Kiura K, Kawaguchi T, Yamamoto N, Miyaoka E, Yoshino I, Date H

    Journal of cachexia, sarcopenia and muscle   2023.03( ISSN:2190-5991

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  • COVID-19 vaccination benefits in preventing severe disease in mild-to-moderate cases: An analysis in the first specialized hospital for COVID-19 in Japan.

    Kobayashi M, Miyamoto A, Watanabe T, Sawa K, Sato K, Yamada K, Yoshii N, Yamada K, Kawamoto K, Uji M, Shiraishi S, Asai K, Kakeya H, Kawaguchi T

    Respiratory investigation   61 ( 2 )   230 - 239   2023.03( ISSN:2212-5345

  • The Impact of Estrogen Receptor Expression on Mutational Status in the Evolution of Non-Small Cell Lung Cancer.

    Tani Y, Kaneda H, Koh Y, Tamiya A, Isa S, Kubo A, Ogawa K, Matsumoto Y, Sawa K, Yoshimoto N, Mitsuoka S, Kawaguchi T

    Clinical lung cancer   24 ( 2 )   165 - 174   2023.03( ISSN:1525-7304

  • Rifampicin exerts anti-mucoviscous activity against hypervirulent Klebsiella pneumoniae via binding to the RNA polymerase β subunit.

    Tohda M, Oinuma KI, Sakiyama A, Tsubouchi T, Niki M, Namikawa H, Yamane K, Yamada K, Watanabe T, Asai K, Kakeya H, Kaneko Y, Kawaguchi T

    Journal of global antimicrobial resistance   32   21 - 28   2023.03( ISSN:2213-7165

  • COVID-19 vaccination benefits in preventing severe disease in mild-to-moderate cases: An analysis in the first specialized hospital for COVID-19 in Japan(タイトル和訳中)

    Kobayashi Masanori, Miyamoto Atsushi, Watanabe Tetsuya, Sawa Kenji, Sato Kanako, Yamada Kazuhiro, Yoshii Naoko, Yamada Koichi, Kawamoto Kengo, Uji Masato, Shiraishi Satoshi, Asai Kazuhisa, Kakeya Hiroshi, Kawaguchi Tomoya

    Respiratory Investigation   61 ( 2 )   230 - 239   2023.03( ISSN:2212-5345

  • Association of combustible cigarettes and heated tobacco products use with SARS-CoV-2 infection and severe COVID-19 in Japan: a JASTIS 2022 cross-sectional study.

    Nishimura M, Asai K, Tabuchi T, Toyokura E, Kawai T, Miyamoto A, Watanabe T, Kawaguchi T

    Scientific reports   13 ( 1 )   1120   2023.02

  • A Culture Supernatant from an Actinomycete sp. Affects Biofilm Formation and Virulence Expression of Candida auris(和訳中)

    Yamane Kenshi, Niki Mamiko, Tsubouchi Taishi, Watanabe Tetsuya, Asai Kazuhisa, Oinuma Ken-Ichi, Sakiyama Arata, Saren Chaogetu, Matsumoto Yuki, Makimura Koichi, Kaneko Yukihiro, Kawaguchi Tomoya

    Medical Mycology Journal   64 ( 1 )   7 - 17   2023.01( ISSN:2185-6486

  • A Culture Supernatant from an Actinomycete sp. Affects Biofilm Formation and Virulence Expression of <i>Candida auris</i>

    Yamane Kenshi, Niki Mamiko, Tsubouchi Taishi, Watanabe Tetsuya, Asai Kazuhisa, Oinuma Ken-Ichi, Sakiyama Arata, Saren Chaogetu, Matsumoto Yuki, Makimura Koichi, Kaneko Yukihiro, Kawaguchi Tomoya

    Medical Mycology Journal   64 ( 1 )   7 - 17   2023( ISSN:21856486 ( eISSN:2186165X

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    The multidrug-resistant pathogen <i>Candida auris</i> is characterized by its aggregation under certain conditions, which affects its biofilm formation, drug susceptibility, and pathogenicity. Although the innate tendency to aggregate depends on the strain, the mechanism regulating <i>C. auris</i> aggregation remains unclear. We found that the culture supernatant from one of the 95 <i>Actinomyces</i> strains isolated from a deep-sea environment (IMAs2016D-66) inhibited <i>C. auris</i> aggregation. The cells grown in the presence of IMAs2016D-66 exhibited reduced hydrophobicity, biofilm formation, and enhanced proteolytic activity. In addition, the efflux pump activity of the fluconazole-resistant <i>C. auris</i> strain LSEM 3673 was stimulated by IMAs2016D-66, whereas no significant change was observed in the fluconazole-susceptible strain LSEM 0643. As the relationship between aggregative tendency and virulence in <i>C. auris</i> is still unclear, IMAs2016D-66 can serve as a tool for investigating regulatory mechanisms of phenotype switching and virulence expression of <i>C. auris</i>. Understanding of phenotype switching may help us not only to understand the pathogenicity of <i>C. auris</i>, but also to design new drugs that target the molecules regulating virulence factors.

    DOI: 10.3314/mmj.22-00026

    PubMed

  • Diagnostic Utility and Safety of Non-Intubated Cryobiopsy Technique Using a Novel Ultrathin Cryoprobe in Addition to Conventional Biopsy Techniques for Peripheral Pulmonary Lesions.

    Nakai T, Watanabe T, Kaimi Y, Shiomi K, Ando K, Miyamoto A, Ogawa K, Matsumoto Y, Sawa K, Sato K, Asai K, Matsumoto Y, Mikami Y, Ohsawa M, Kawaguchi T

    Respiration; international review of thoracic diseases   102 ( 7 )   503 - 514   2023( ISSN:0025-7931

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  • A cross-sectional, multicenter survey of the prevalence and risk factors for Long COVID.

    Imoto W, Yamada K, Kawai R, Imai T, Kawamoto K, Uji M, Kanda H, Takada M, Ohno Y, Ohtani H, Kono M, Hikiishi A, Eguchi Y, Namikawa H, Kawaguchi T, Kakeya H

    Scientific reports   12 ( 1 )   22413   2022.12

  • SP142 evaluation contributes to the prediction of immune checkpoint inhibitor efficacy in non-small cell lung cancer with high PD-L1 expression assessed by 22C3.

    Nakahama K, Osawa M, Izumi M, Yoshimoto N, Sugimoto A, Nagamine H, Ogawa K, Matsumoto Y, Sawa K, Tani Y, Kaneda H, Mitsuoka S, Watanabe T, Asai K, Kawaguchi T

    Translational lung cancer research   11 ( 12 )   2438 - 2451   2022.12( ISSN:2218-6751

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  • Differential properties of KRAS transversion and transition mutations in non-small cell lung cancer: associations with environmental factors and clinical outcomes.

    Sato K, Akamatsu H, Koh Y, Ogawa K, Isa SI, Ando M, Tamiya A, Kubo A, Kitagawa C, Kawaguchi T, Yamamoto N

    BMC cancer   22 ( 1 )   1148   2022.11

  • Clopidogrel-induced Eosinophilia with Hypercalcemia

    Yamada Kazuhiro, Asai Kazuhisa, Yanagimoto Misaki, Sone Risa, Inazu Satsuki, Mizutani Ryo, Kadotani Hideaki, Watanabe Tetsuya, Tochino Yoshihiro, Kawaguchi Tomoya

    Internal Medicine   61 ( 17 )   2681 - 2685   2022.09( ISSN:0918-2918 ( eISSN:13497235

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    <p>There are few cases describing the association of eosinophilia with hypercalcemia, and drug-induced eosinophilia with hypercalcemia has not been reported. A 74-year-old man had been diagnosed with asthma 4 months earlier. He was admitted due to eosinophilia with hypercalcemia. Chest computed tomography showed a nodule in the left lung and mediastinal lymphadenopathy. By obtaining a detailed medical history, clopidogrel was suspected as the prime cause of eosinophilia. After the discontinuation of clopidogrel, the eosinophilia with hypercalcemia, lung nodule and mediastinal lymphadenopathy improved. Clopidogrel-induced eosinophilia can potentially cause hypercalcemia. Obtaining a detailed clinical history is important in diagnosing the cause of eosinophilia. </p>

    DOI: 10.2169/internalmedicine.7830-21

    PubMed

    CiNii Article

  • Vascular endothelial growth factor receptor 2 expression and immunotherapy efficacy in non-small cell lung cancer(和訳中)

    Nakahama Kenji, Kaneda Hiroyasu, Osawa Masahiko, Fukui Mitsuru, Izumi Motohiro, Yoshimoto Naoki, Sugimoto Akira, Nagamine Hiroaki, Ogawa Koichi, Matsumoto Yoshiya, Sawa Kenji, Tani Yoko, Mitsuoka Shigeki, Watanabe Tetsuya, Asai Kazuhisa, Kawaguchi Tomoya

    Cancer Science   113 ( 9 )   3148 - 3160   2022.09( ISSN:1347-9032

  • Idiopathic Obliterative Bronchiolitis in a Young Woman: A Rare Case of a Transbronchial Lung Biopsy Contributing to the Diagnosis(和訳中)

    Yoshii Naoko, Kamoi Hiroshi, Matsui Erika, Sato Kanako, Nakai Toshiyuki, Yamada Kazuhiro, Watanabe Tetsuya, Asai Kazuhisa, Kanazawa Hiroshi, Kawaguchi Tomoya

    Internal Medicine   61 ( 18 )   2759 - 2764   2022.09( ISSN:0918-2918

  • Clopidogrel-induced Eosinophilia with Hypercalcemia(和訳中)

    Yamada Kazuhiro, Asai Kazuhisa, Yanagimoto Misaki, Sone Risa, Inazu Satsuki, Mizutani Ryo, Kadotani Hideaki, Watanabe Tetsuya, Tochino Yoshihiro, Kawaguchi Tomoya

    Internal Medicine   61 ( 17 )   2681 - 2685   2022.09( ISSN:0918-2918

  • A Case of Other Iatrogenic Immunodeficiency-associated Lymphoproliferative Disorders Induced by Methotrexate with Extensive Tracheobronchial Involvement

    Inada Yuya, Itoh Tomoyoshi, Iwasaki Kohei, Furukawa Yuichiro, Mizutani Ryo, Shinoki Masato, Akagi Kanako, Sakurai Takaki, Kawaguchi Tomoya

    The Journal of the Japan Society for Respiratory Endoscopy   44 ( 4 )   305 - 312   2022.07( ISSN:02872137 ( eISSN:21860149

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    <p><b><i>Background.</i></b> Other iatrogenic immunodeficiency-associated lymphoproliferative disorders (OIIA-LPD) are caused by immunosuppressive agents such as methotrexate (MTX). We report a rare case of MTX-induced OIIA-LPD with extensive tracheal and bronchial lesions diagnosed based on endobronchial biopsy (EBB). <b><i>Case.</i></b> The patient was a 75-year-old woman who was diagnosed with rheumatoid arthritis 15 years previously, and MTX treatment was initiated at the time of the diagnosis. One year prior to her current presentation, computed tomography (CT) revealed a mass shadow in the left lower lobe of the chest, which gradually increased in size; thus, bronchoscopy was performed. Endoscopic findings revealed multiple elevated lesions in the trachea and bronchi, which could not be detected using CT. Pathological EBB findings indicated lymphoproliferative disorders (LPD). Two months after the discontinuation of MTX, endoscopic findings revealed shrinkage of the tracheal mass and a mass shadow in the left lower lobe, which led to the diagnosis of MTX-induced OIIA-LPD. <b><i>Conclusion.</i></b> When a mass shadow appears in the lung field during long-term MTX treatment and MTX-induced OIIA-LPD is suspected, bronchoscopy is essential for determining the presence of extensive airway lesions. EBB of airway lesions is considered important for the diagnosis of MTX-induced OIIA-LPD.</p>

    DOI: 10.18907/jjsre.44.4_305

  • Prognostic impact of pretreatment T790M mutation on outcomes for patients with resected, EGFR-mutated, non-small cell lung cancer.

    Matsumoto Y, Kawaguchi T, Watanabe M, Isa SI, Ando M, Tamiya A, Kubo A, Kitagawa C, Yoshimoto N, Koh Y

    BMC cancer   22 ( 1 )   775   2022.07

  • Association of thyroid transcription factor-1 with the efficacy of immune-checkpoint inhibitors in patients with advanced lung adenocarcinoma.

    Nakahama K, Kaneda H, Osawa M, Izumi M, Yoshimoto N, Sugimoto A, Nagamine H, Ogawa K, Matsumoto Y, Sawa K, Tani Y, Mitsuoka S, Watanabe T, Asai K, Kawaguchi T

    Thoracic cancer   2022.07( ISSN:1759-7706

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  • Response biomarkers of inhalation exposure to cigarette smoke in the mouse lung.

    Suzuki S, Asai K, Gi M, Kojima K, Kakehashi A, Oishi Y, Matsue T, Yukimatsu N, Hirata K, Kawaguchi T, Wanibuchi H

    Journal of toxicologic pathology   35 ( 3 )   247 - 254   2022.07( ISSN:0914-9198

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  • 広範な気管・気管支内病変を認めたメトトレキサートによる医原性免疫不全症関連リンパ増殖性疾患の1例

    稲田 祐也, 伊東 友好, 岩崎 剛平, 古川 雄一郎, 水谷 亮, 篠木 聖徳, 赤木 佳菜子, 桜井 孝規, 川口 知哉

    気管支学   44 ( 4 )   305 - 312   2022.07( ISSN:0287-2137

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    背景.他の医原性免疫不全症関連リンパ増殖性疾患(other iatrogenic immunodeficiency-associated lymphoproliferative disorders:OIIA-LPD)は,メトトレキサート(methotrexate:MTX)などの免疫抑制薬により発症する.広範な気管・気管支内病変を認め,直視下生検(endobronchial biopsy:EBB)でMTXによるOIIA-LPDと診断した稀な症例を経験したため報告する.症例.75歳,女性.15年前に関節リウマチ(rheumatoid arthritis:RA)と診断され同年よりMTXが開始となった.1年前より胸部CTで左下葉に腫瘤影が出現し,緩徐に増大したため気管支鏡検査を行った.内視鏡所見では,CTで指摘し得なかった部位である気管・気管支内に多発する隆起性病変を認め,EBBの病理所見はリンパ増殖性疾患(lymphoproliferative disorders:LPD)であった.MTX中止2ヵ月後に内視鏡所見で気管の腫瘤および左下葉の腫瘤影は縮小し,MTXによるOIIA-LPDと診断した.結論.MTX長期投与中に,肺野に腫瘤影などが出現しMTX-LPDが疑われた際には,広範な気道病変に留意し気管支鏡検査を行い,気道病変があればEBBを行うことがMTXによるOIIA-LPDの診断に重要と考える.(著者抄録)

  • Response biomarkers of inhalation exposure to cigarette smoke in the mouse lung(和訳中)

    Suzuki Shugo, Asai Kazuhisa, Gi Min, Kojima Kazuya, Kakehashi Anna, Oishi Yuji, Matsue Taisuke, Yukimatsu Nao, Hirata Kazuto, Kawaguchi Tomoya, Wanibuchi Hideki

    Journal of Toxicologic Pathology   35 ( 3 )   247 - 254   2022.07( ISSN:0914-9198

  • Vascular endothelial growth factor receptor 2 expression and immunotherapy efficacy in non-small cell lung cancer.

    Nakahama K, Kaneda H, Osawa M, Fukui M, Izumi M, Yoshimoto N, Sugimoto A, Nagamine H, Ogawa K, Matsumoto Y, Sawa K, Tani Y, Mitsuoka S, Watanabe T, Asai K, Kawaguchi T

    Cancer science   2022.06( ISSN:1347-9032

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  • Paradoxical Reaction of Tuberculosis that was Histologically Diagnosed with Multiple Imaging Changes 15 Months After the Initiation of Treatment: a Case Report

    Kuwabara Gaku, Okamoto Atsuko, Yamada Koichi, Imoto Waki, Shibata Wataru, Toda Mitsunori, Watanabe Tetsuya, Kawaguchi Tomoya, Kakeya Hiroshi

    The Journal of the Japan Society for Respiratory Endoscopy   44 ( 3 )   199 - 204   2022.05( ISSN:02872137 ( eISSN:21860149

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    <p><b><i>Background.</i></b> A paradoxical reaction is a phenomenon that causes a transient exacerbation of existing lesions or fever after the initiation of tuberculosis treatment, and it is often difficult to differentiate from other diseases. <b><i>Case Presentation.</i></b> A 35-year-old woman with Crohn's disease was referred to our hospital for the evaluation of fever and an abnormal shadow on chest radiography. She was diagnosed with pulmonary tuberculosis and miliary tuberculosis based on a positive sputum smear for acid-fast bacilli; and a positive polymerase chain reaction for <i>Mycobacterium tuberculosis</i>, and treatment with anti-tuberculous drugs was initiated. A negative sputum smear for acid-fast bacilli and the regression of the lesions were confirmed after the initiation of treatment. However, she developed worsening cough 15 months after the initiation of treatment. Furthermore, chest computed tomography revealed enlargement of the mediastinal lymph nodes, enlargement of the consolidation in the right lower lobe, and a bronchial polyp at the truncus intermedius. A sputum smear for acid-fast bacilli was positive. Bronchoscopic biopsy of each lesion was performed, and a histopathological examination revealed caseous necrosis and epithelioid cells; however, no acid-fast bacilli were detected in the biopsy specimens. We continued anti-tuberculosis treatment because we considered that these lesions had formed as a result of a paradoxical reaction. Treatment was discontinued when cultures of bronchoscopic specimens to detect acid-fast bacilli were confirmed to be negative. <b><i>Conclusion.</i></b> Physicians should be aware that paradoxical reactions can occur late in the course of treatment and may have multiple manifestations, and a histological diagnosis should be performed to exclude other diseases.</p>

    DOI: 10.18907/jjsre.44.3_199

  • 治療開始15ヵ月後に複数の画像的変化を呈し、組織学的に診断した結核paradoxical reactionの1例

    桑原 学, 岡本 敦子, 山田 康一, 井本 和紀, 柴多 渉, 東田 充功, 渡辺 徹也, 川口 知哉, 掛屋 弘

    気管支学   44 ( 3 )   199 - 204   2022.05( ISSN:0287-2137

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    背景.Paradoxical reactionは結核治療開始後に一過性に既存病変の悪化や発熱などを生じる現象であり,しばしば他疾患との鑑別に難渋する.症例.クローン病治療中の35歳女性.発熱と胸部異常陰影精査のため当院を紹介受診した.喀痰抗酸菌塗抹,結核菌群PCRともに陽性であり肺結核および粟粒結核と診断した.結核専門病院で入院治療を行い,退院後は当院で治療を継続し画像所見の改善も認めていた.しかし治療開始15ヵ月後から咳嗽悪化と喀痰抗酸菌塗抹再陽性化を認めたほか,胸部CTで縦隔リンパ節と右下葉コンソリデーションの増大,中間幹のポリープ様病変を認めた.気管支鏡にて各病変の生検を施行したところ乾酪壊死と類上皮細胞を認めたが,抗酸菌は検出されなかった.Paradoxical reactionによる変化と考え結核治療を継続したところ症状は改善し,気管支鏡検体の抗酸菌培養陰性確認をもって治療を終了した.結論.Paradoxical reactionでは遅発性に複数の所見を呈することがあり,他疾患除外のためにできる限り組織学的診断を行うべきである.(著者抄録)

  • Safe Concurrent Use of Anti-tuberculosis Drugs and Pembrolizumab in a Patient with Non-small-cell Lung Cancer Who Was Infected with Mycobacterium tuberculosis(和訳中)

    Nakahama Kenji, Kaneda Hiroyasu, Ogawa Koichi, Matsumoto Yoshiya, Tani Yoko, Suzumura Tomohiro, Mitsuoka Shigeki, Watanabe Tetsuya, Asai Kazuhisa, Kawaguchi Tomoya

    Internal Medicine   61 ( 7 )   1039 - 1042   2022.04( ISSN:0918-2918

  • RELAY+: Exploratory Study of Ramucirumab Plus Gefitinib in Untreated Patients With <i>EGFR</i>-Mutated Metastatic NSCLC.

    Nishio M, Nishio K, Reck M, Garon EB, Imamura F, Kawaguchi T, Yamaguchi H, Ikeda S, Hirano K, Visseren-Grul C, Ceccarelli M, Wijayawardana SR, Zimmermann A, Matsui T, Enatsu S, Nakagawa K

    JTO clinical and research reports   3 ( 4 )   100303   2022.04

  • Efficacy of platinum agents for stage III non-small-cell lung cancer following platinum-based chemoradiotherapy: a retrospective study.

    Miyawaki E, Kenmotsu H, Shintani Y, Sekine I, Shukuya T, Takayama K, Inoue A, Okamoto I, Kiura K, Takahashi K, Yamamoto N, Kawaguchi T, Miyaoka E, Yoshino I, Date H

    BMC cancer   22 ( 1 )   342   2022.03

  • Idiopathic Obliterative Bronchiolitis in a Young Woman: A Rare Case of a Transbronchial Lung Biopsy Contributing to the Diagnosis

    Yoshii Naoko, Kamoi Hiroshi, Matsui Erika, Sato Kanako, Nakai Toshiyuki, Yamada Kazuhiro, Watanabe Tetsuya, Asai Kazuhisa, Kanazawa Hiroshi, Kawaguchi Tomoya

    Internal Medicine   advpub ( 0 )   2022.03( ISSN:0918-2918 ( eISSN:13497235

  • Bronchial Artery Aneurysm: Prevalence, Clinical Characteristics, and Long-Term Prognosis Following Bronchial Artery Embolization.

    Omachi N, Ishikawa H, Nishihara T, Yamaguchi Y, Kitaoka A, Kitaguchi K, Hattori T, Kawaguchi T

    Journal of vascular and interventional radiology : JVIR   33 ( 2 )   121 - 129   2022.02( ISSN:1051-0443

  • Safety profile and risk factors for bleeding in transbronchial cryobiopsy using a two-scope technique for peripheral pulmonary lesions.

    Nakai T, Watanabe T, Kaimi Y, Ogawa K, Matsumoto Y, Sawa K, Okamoto A, Sato K, Asai K, Matsumoto Y, Ohsawa M, Kawaguchi T

    BMC pulmonary medicine   22 ( 1 )   20   2022.01

  • 症例 ベムラフェニブ投与により一時的に呼吸器症状が改善した悪性黒色腫多発転移の1例

    林 大輔, 中井 浩三, 加茂 理英, 川口 知哉, 大澤 政彦, 大山 綾子, 楠谷 尚, 鶴田 大輔

    皮膚科の臨床   64 ( 1 )   133 - 136   2022.01( ISSN:00181404

  • ベムラフェニブ投与により一時的に呼吸器症状が改善した悪性黒色腫多発転移の1例

    林 大輔, 中井 浩三, 加茂 理英, 川口 知哉, 大澤 政彦, 大山 綾子, 楠谷 尚, 鶴田 大輔

    皮膚科の臨床   64 ( 1 )   133 - 136   2022.01( ISSN:0018-1404

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    <文献概要>43歳,男性。2007年頃に左腰部の色素斑が隆起してきた。悪性黒色腫(T4bN1aM0,Stage IIIA)の診断であり,2012年当科を受診した。腫瘍切除後の追加治療は希望されず,受診も自己中断していた。2015年,悪性黒色腫の肺転移が判明し,右上葉の胸水貯留と呼吸苦のため入院した。ベムラフェニブ投与25日後に症状は軽快し,一時退院することができた。以後は通院でベムラフェニブ内服を継続,60日後に再度胸水が貯留し,心外閉塞・拘束性ショックにより永眠された。分子標的薬や免疫チェックポイント阻害薬により,悪性黒色腫末期患者の生存期間の延長だけでなく,生活の質の向上が望めると考えられた。

  • Safe Concurrent Use of Anti-tuberculosis Drugs and Pembrolizumab in a Patient with Non-small-cell Lung Cancer Who Was Infected with <i>Mycobacterium tuberculosis</i>

    Nakahama Kenji, Kaneda Hiroyasu, Ogawa Koichi, Matsumoto Yoshiya, Tani Yoko, Suzumura Tomohiro, Mitsuoka Shigeki, Watanabe Tetsuya, Asai Kazuhisa, Kawaguchi Tomoya

    Internal Medicine   61 ( 7 )   1039 - 1042   2022( ISSN:0918-2918 ( eISSN:13497235

  • The power of genetic diversity in genome-wide association studies of lipids

    Graham S.E.

    Nature   600 ( 7890 )   675 - 679   2021.12( ISSN:00280836

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  • Impact of the COVID-19 Pandemic on Patients with Gastrointestinal Cancer Undergoing Active Cancer Treatment in an Ambulatory Therapy Center: The Patients' Perspective.

    Taira K, Nagahara H, Tanaka H, Kimura A, Nakata A, Iseki Y, Fukuoka T, Shibutani M, Toyokawa T, Lee S, Muguruma K, Ohira M, Kawaguchi T, Fujiwara Y

    Healthcare (Basel, Switzerland)   9 ( 12 )   2021.12

  • Phase II Study of the Modified Weekly Nab-paclitaxel Regimen in Previously Treated Patients With Advanced Non-Small Cell Lung Cancer.

    Yoshimura N, Sawa K, Nakai T, Matsumoto Y, Mitsuoka S, Kimura T, Asai K, Yana T, Kawaguchi T, Hirata K

    American journal of clinical oncology   44 ( 12 )   613 - 618   2021.12( ISSN:0277-3732

  • Phase 1b study of ramucirumab in combination with erlotinib or osimertinib for untreated EGFR-mutated non-small cell lung cancer patients with asymptomatic brain metastases.

    Kaneda H, Sawa K, Daga H, Okada A, Nakatani Y, Atagi S, Okishio K, Tani Y, Matsumoto Y, Ogawa K, Nakahama K, Izumi M, Mitsuoka S, Kawaguchi T

    Investigational new drugs   39 ( 6 )   1598 - 1603   2021.12( ISSN:0167-6997

  • The prevalence of artificially administered nutrition and hydration in different age groups among patients with advanced cancer admitted to palliative care units

    Amano K.

    Clinical Nutrition Open Science   40   69 - 78   2021.12( ISSN:26672685

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  • Isoniazid-induced Immune Thrombocytopenia

    Kuwabara Gaku, Tazoe Kumiyo, Imoto Waki, Yamairi Kazushi, Shibata Wataru, Oshima Kazuhiro, Yamada Koichi, Takagi Yasuhiro, Shiraishi Satoshi, Hino Masayuki, Kawaguchi Tomoya, Kakeya Hiroshi

    Internal Medicine   60 ( 22 )   3639 - 3643   2021.11( ISSN:0918-2918 ( eISSN:13497235

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    <p>Drug-induced thrombocytopenia occurs through immune-mediated platelet destruction, and its management is challenging during tuberculosis treatment. Although rifampicin is the most common drug causing thrombocytopenia, isoniazid can also cause thrombocytopenia. We herein report a 75-year-old man who developed thrombocytopenia during tuberculosis treatment. Platelet-associated immunoglobulin G and a drug-induced lymphocyte stimulation test for isoniazid were positive; no other causes of thrombocytopenia were identified. The patient was diagnosed with isoniazid-induced immune thrombocytopenia, and the platelet count normalized after isoniazid discontinuation. We describe the immunological mechanism of thrombocytosis due to isoniazid, an uncommon cause of thrombocytopenia that physicians should be aware exists. </p>

    DOI: 10.2169/internalmedicine.6520-20

    PubMed

    CiNii Article

  • Pretreatment Platelet Count and Neutrophil/Lymphocyte Ratio Are Predictive Markers for Carboplatin Plus Pemetrexed Therapy-induced Thrombocytopenia.

    Takahashi M, Takahashi K, Kaneda H, Kawaguchi T, Nagayama K

    Anticancer research   41 ( 11 )   5729 - 5737   2021.11( ISSN:0250-7005

  • Isoniazid-induced Immune Thrombocytopenia(和訳中)

    Kuwabara Gaku, Tazoe Kumiyo, Imoto Waki, Yamairi Kazushi, Shibata Wataru, Oshima Kazuhiro, Yamada Koichi, Takagi Yasuhiro, Shiraishi Satoshi, Hino Masayuki, Kawaguchi Tomoya, Kakeya Hiroshi

    Internal Medicine   60 ( 22 )   3639 - 3643   2021.11( ISSN:0918-2918

  • Invasive pulmonary aspergillosis caused by Aspergillus terreus diagnosed using virtual bronchoscopic navigation and endobronchial ultrasonography with guide sheath and successfully treated with liposomal amphotericin B.

    Yoshii N, Yamada K, Niki M, Imoto W, Yamairi K, Shibata W, Namikawa H, Sakatoku K, Sato K, Nakai T, Yamada K, Watanabe T, Asai K, Kakeya H, Kawaguchi T

    Infection   49 ( 5 )   1049 - 1054   2021.10( ISSN:0300-8126

  • The Fermented Soy Product ImmuBalance<sup>TM</sup> Suppresses Airway Inflammation in a Murine Model of Asthma.

    Kadotani H, Asai K, Miyamoto A, Iwasaki K, Kawai T, Nishimura M, Tohda M, Okamoto A, Sato K, Yamada K, Ijiri N, Watanabe T, Kawaguchi T

    Nutrients   13 ( 10 )   2021.09

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  • Smallest Organic Tetracation in the Gas Phase: Stability of Multiply Charged Diiodoacetylene Produced in Intense Femtosecond Laser Fields

    Kawaguchi T.

    Journal of Physical Chemistry A   125 ( 36 )   8014 - 8024   2021.09( ISSN:10895639

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  • 〈Bronchoscope Textbook 3rd. edition〉

    The Japan Society for Respiratory Endoscopy, Ohsaki Yoshinobu, Kawaguchi Tomoya

    The Journal of the Japan Society for Respiratory Endoscopy   43 ( 4 )   307 - 308   2021.07( ISSN:02872137 ( eISSN:21860149

  • Tumor microenvironment disparity in multiple primary lung cancers: Impact of non-intrinsic factors, histological subtypes, and genetic aberrations.

    Izumi M, Sawa K, Oyanagi J, Noura I, Fukui M, Ogawa K, Matsumoto Y, Tani Y, Suzumura T, Watanabe T, Kaneda H, Mitsuoka S, Asai K, Nishiyama N, Ohsawa M, Yamamoto N, Koh Y, Kawaguchi T

    Translational oncology   14 ( 7 )   101102   2021.07

  • The impact of bronchial artery embolisation on the quality of life of patients with haemoptysis: a prospective observational study.

    Omachi N, Ishikawa H, Hara M, Nishihara T, Yamaguchi Y, Yamamoto Y, Youmoto M, Hattori T, Kitaguchi K, Yamamoto S, Kawaguchi T, Fukuzawa M

    European radiology   31 ( 7 )   5351 - 5360   2021.07( ISSN:0938-7994

  • Corynebacterium jeikeium-induced infective endocarditis and perivalvular abscess diagnosed by 16S ribosomal RNA sequence analysis: A case report.

    Imoto W, Takahashi Y, Yamada K, Hojo K, Kawase T, Sakon Y, Kuwabara G, Yamairi K, Shibata W, Oshima K, Ogawa M, Niki M, Nakaie K, Watanabe T, Asai K, Kaneko Y, Kawaguchi T, Shibata T, Kakeya H

    Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy   27 ( 6 )   906 - 910   2021.06( ISSN:1341-321X

  • 16SリボソームRNAシーケンス解析により診断されたCorynebacterium jeikeium誘導の感染性心内膜炎と弁周囲膿瘍 症例報告(Corynebacterium jeikeium-induced infective endocarditis and perivalvular abscess diagnosed by 16S ribosomal RNA sequence analysis: A case report)

    Imoto Waki, Takahashi Yosuke, Yamada Koichi, Hojo Kana, Kawase Takumi, Sakon Yoshito, Kuwabara Gaku, Yamairi Kazushi, Shibata Wataru, Oshima Kazuhiro, Ogawa Masashi, Niki Makoto, Nakaie Kiyotaka, Watanabe Tetsuya, Asai Kazuhisa, Kaneko Yukihiro, Kawaguchi Tomoya, Shibata Toshihiko, Kakeya Hiroshi

    Journal of Infection and Chemotherapy   27 ( 6 )   906 - 910   2021.06( ISSN:1341-321X

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    症例は66歳男性で、持続性発熱と腰痛を主訴とした。5年前に大動脈弁狭窄症(AS)と診断されていた。1年前に労作時呼吸困難と倦怠感が観察され、10ヵ月前の心電図検査で重度のASと判明していた。8ヵ月前の冠動脈CTと血管造影検査で右冠動脈狭窄症と左前下行枝狭窄症が判明していた。5ヵ月前に冠動脈バイパスと生体弁による大動脈弁置換術を受けていた。持続性完全房室ブロックのため4ヵ月前までペースメーカーを埋め込んでいた。術後2〜3ヵ月後から発熱と腰痛が出現した。受診時のCRP値は高値であった。心雑音、Janeway病変、Osler結節はみられなかった。経食道心エコー図検査で僧帽弁の前尖に2個の疣贅と弁周囲膿瘍が見つかった。MRI検査で第4/5腰椎化膿性椎間板炎が判明した。タゾバクタム/ピペラシリン(TAZ/PIPC)とバンコマイシン(VCM)による経験的治療を開始し、血液培養を行った。化膿性椎間板炎は抗菌薬療法で治療した。血液からCorynebacterium jeikeiumが分離された。入院6日目にBentall処置、弁輪パッチ修復、三尖弁形成を行い、弁周囲膿瘍を摘出した。膿瘍から菌は培養されなかったが、16SリボソームRNAのシーケンス解析でC.jeikeiumシーケンスと相同性が100%一致した。分離菌がペニシリン耐性、VCM感受性のため、VCM静脈内投与を6週間継続後、リネゾリドに変更し、退院した。

  • 大阪での2019〜2020年のインフルエンザ流行期における各種抗インフルエンザ薬投与後のインフルエンザ罹患患者の臨床経過(The Clinical Course of Patients with Influenza after Administration of Various Anti-influenza Drugs during the 2019-2020 Influenza Season in Osaka, Japan)

    Maruyama Naomi, Yoshii Naoko, Tochino Yoshihiro, Fujioka Masashi, Asai Kazuhisa, Hamazaki Takashi, Kakeya Hiroshi, Kawaguchi Tomoya

    Osaka City Medical Journal   67 ( 1 )   45 - 55   2021.06( ISSN:0030-6096

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    キャップ依存性エンドヌクレアーゼであるbaloxavir marboxil(以下、baloxavir)とノイラミニダーゼ阻害薬の臨床効果を比較した報告は少ない。本研究では、2019〜2020年のインフルエンザ流行期における各種抗インフルエンザ薬投与後のインフルエンザ罹患患者の臨床経過を調査した。インフルエンザの迅速診断キットで陽性の診断を受けた患者に対して質問紙調査が送付され、有効回答の得られたインフルエンザ罹患患者252例(男性120例、女性132例、平均21.8歳)を解析対象とした。baloxavirは10歳未満の患者97例のうち3例(3.1%)に、10歳以上の患者155例のうち19例(12.3%)に投与された。抗インフルエンザ薬が投与された患者の発熱期間の中央値は2〜2.5日であり、oseltamivir(94例)、laninamivir(101例)、zanamivir(32例)またはbaloxavir(22例)の抗インフルエンザ薬の違いによる有意な差はなかった。249例中10例(4.0%)で2相性の発熱エピソードが生じたが、2相性の発熱エピソードの発症頻度と抗インフルエンザ薬の選択に有意な差はなかった。各有害事象の発生頻度にも4群間で差はなかった。以上の結果より、baloxavirの投与と早期発熱の緩和および2相性の発熱エピソードの発症頻度には有意な関連性がないことが示された。

  • The trans-ancestral genomic architecture of glycemic traits

    Chen J.

    Nature Genetics   53 ( 6 )   840 - 860   2021.06( ISSN:10614036

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  • In which cases of pneumonia should we consider treatments for Stenotrophomonas maltophilia?

    Imoto W.

    Journal of Hospital Infection   111   169 - 175   2021.05( ISSN:01956701

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  • Type IV Collagen 7S Is the Most Accurate Test For Identifying Advanced Fibrosis in NAFLD With Type 2 Diabetes

    Ishiba H.

    Hepatology Communications   5 ( 4 )   559 - 572   2021.04

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  • Mutational landscape of multiple primary lung cancers and its correlation with non-intrinsic risk factors. Reviewed

    Izumi M, Oyanagi J, Sawa K, Fukui M, Ogawa K, Matsumoto Y, Tani Y, Suzumura T, Watanabe T, Kaneda H, Mitsuoka S, Asai K, Ohsawa M, Yamamoto N, Koh Y, Kawaguchi T

    Scientific reports   11 ( 1 )   5680   2021.03

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41598-021-83609-y

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  • Mutational landscape of multiple primary lung cancers and its correlation with non-intrinsic risk factors.

    Izumi M, Oyanagi J, Sawa K, Fukui M, Ogawa K, Matsumoto Y, Tani Y, Suzumura T, Watanabe T, Kaneda H, Mitsuoka S, Asai K, Ohsawa M, Yamamoto N, Koh Y, Kawaguchi T

    Scientific reports   11 ( 1 )   5680   2021.03

  • Incidental finding of neurosyphilis with intracranial hemorrhage and cerebral infarction: A case report Reviewed

    Imoto Waki, Arima Hironori, Yamada Koichi, Kanzaki Toshiyuki, Nakagawa Chihiro, Kuwabara Gaku, Yamairi Kazushi, Shibata Wataru, Oshima Kazuhiro, Watanabe Tetsuya, Asai Kazuhisa, Kaneko Yukihiro, Kawaguchi Tomoya, Goto Takeo, Kakeya Hiroshi

    JOURNAL OF INFECTION AND CHEMOTHERAPY   27 ( 3 )   521 - 525   2021.03( ISSN:1341-321X

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.jiac.2020.10.001

    PubMed

  • 頭蓋内出血と脳梗塞を伴う神経梅毒の偶発所見 症例報告(Incidental finding of neurosyphilis with intracranial hemorrhage and cerebral infarction: A case report)

    Imoto Waki, Arima Hironori, Yamada Koichi, Kanzaki Toshiyuki, Nakagawa Chihiro, Kuwabara Gaku, Yamairi Kazushi, Shibata Wataru, Oshima Kazuhiro, Watanabe Tetsuya, Asai Kazuhisa, Kaneko Yukihiro, Kawaguchi Tomoya, Goto Takeo, Kakeya Hiroshi

    Journal of Infection and Chemotherapy   27 ( 3 )   521 - 525   2021.03( ISSN:1341-321X

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    症例は神経梅毒の49歳男性。道端で意識を失い、救急搬送された。CTとMRIにて脳出血、複数の脳梗塞と脳血管の径の不整が観察されたため、入院した日に脳出血に対する手術を行った。その原因は梅毒によることが疑われた。入院した日にペニシリンによる抗菌薬治療を開始し、血清と髄液試験の結果から次の週に梅毒と診断した。病状が改善したので、ベンジルペニシリンの3週間の注入療法とその後にアモキシシリン経口投与を行い、転院した。

  • Incidental finding of neurosyphilis with intracranial hemorrhage and cerebral infarction: A case report.

    Imoto W, Arima H, Yamada K, Kanzaki T, Nakagawa C, Kuwabara G, Yamairi K, Shibata W, Oshima K, Watanabe T, Asai K, Kaneko Y, Kawaguchi T, Goto T, Kakeya H

    Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy   27 ( 3 )   521 - 525   2021.03( ISSN:1341-321X

  • Corynebacterium jeikeium-induced infective endocarditis and perivalvular abscess diagnosed by 16S ribosomal RNA sequence analysis: A case report. Reviewed

    Imoto W, Takahashi Y, Yamada K, Hojo K, Kawase T, Sakon Y, Kuwabara G, Yamairi K, Shibata W, Oshima K, Ogawa M, Niki M, Nakaie K, Watanabe T, Asai K, Kaneko Y, Kawaguchi T, Shibata T, Kakeya H

    Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy   2021.02( ISSN:1341-321X

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.jiac.2021.01.005

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  • Is Cancer Panel Testing useful for cancer treatment? Reviewed

    Nishimura Sadaaki, Sugimoto Atsushi, Kushiyama Shuhei, Togano Shingo, Kuroda Kenji, Yamauchi Makoto, Sumi Toshiyuki, Sawa Kenji, Kawaguchi Tomoya, Kimura Kenjiro, Nagahara Hisashi, Muguruma Kazuya, Takashima Tsutomu, Ohira Masaichi, Yashiro Masakazu

    CANCER SCIENCE   112   325 - 325   2021.02( ISSN:1347-9032

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    Publishing type:Research paper (scientific journal)  

  • Structure Design of Long-Life Spinel-Oxide Cathode Materials for Magnesium Rechargeable Batteries.

    Shimokawa K, Atsumi T, Okamoto NL, Kawaguchi T, Imashuku S, Wagatsuma K, Nakayama M, Kanamura K, Ichitsubo T

    Advanced materials (Deerfield Beach, Fla.)   33 ( 7 )   e2007539   2021.02( ISSN:0935-9648

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  • Congenital bronchial atresia complicated by a lung abscess due to Aspergillus fumigatus: a case report Reviewed

    Kuwabara Gaku, Sone Risa, Imoto Waki, Yamairi Kazushi, Shibata Wataru, Oshima Kazuhiro, Yamada Koichi, Yamada Kazuhiro, Watanabe Tetsuya, Asai Kazuhisa, Komatsu Hiroaki, Izumi Nobuhiro, Nishiyama Noritoshi, Kawaguchi Tomoya, Kakeya Hiroshi

    BMC PULMONARY MEDICINE   21 ( 1 )   2   2021.01( ISSN:1471-2466

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s12890-020-01367-5

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  • The impact of bronchial artery embolisation on the quality of life of patients with haemoptysis: a prospective observational study Reviewed

    Omachi Naoki, Ishikawa Hideo, Hara Masahiko, Nishihara Takashi, Yamaguchi Yu, Yamamoto Yumiko, Youmoto Mihoko, Hattori Tomoaki, Kitaguchi Kazushi, Yamamoto Shota, Kawaguchi Tomoya, Fukuzawa Masahiro

    EUROPEAN RADIOLOGY   2021.01( ISSN:0938-7994

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00330-020-07533-x

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  • Congenital bronchial atresia complicated by a lung abscess due to Aspergillus fumigatus: a case report.

    Kuwabara G, Sone R, Imoto W, Yamairi K, Shibata W, Oshima K, Yamada K, Yamada K, Watanabe T, Asai K, Komatsu H, Izumi N, Nishiyama N, Kawaguchi T, Kakeya H

    BMC pulmonary medicine   21 ( 1 )   2   2021.01

  • Invasive pulmonary aspergillosis caused by Aspergillus terreus diagnosed using virtual bronchoscopic navigation and endobronchial ultrasonography with guide sheath and successfully treated with liposomal amphotericin B Reviewed

    Yoshii Naoko, Yamada Koichi, Niki Makoto, Imoto Waki, Yamairi Kazushi, Shibata Wataru, Namikawa Hiroki, Sakatoku Kazuki, Sato Kanako, Nakai Toshiyuki, Yamada Kazuhiro, Watanabe Tetsuya, Asai Kazuhisa, Kakeya Hiroshi, Kawaguchi Tomoya

    INFECTION   2021.01( ISSN:0300-8126

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s15010-020-01545-x

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  • Does clinical sequencing bridge to clinical benefit in cancer treatment? Reviewed

    Nishimura Sadaaki, Kato Minoru, Kimura Kenjiro, Nagahara Hisashi, Muguruma Kazuya, Lee Shigeru, Takashima Tsutomu, Kubo Shoji, Ohira Masaichi, Yashiro Masakazu, Sugimoto Atsushi, Kushiyama Shuhei, Togano Shingo, Kuroda Kenji, Yamauchi Makoto, Sumi Toshiyuki, Kaneda Hiroyasu, Kawaguchi Tomoya

    Japanese Society for Molecular Tumor Marker Research, Japan Journal of Molecular Tumor Marker Research   36 ( 0 )   5 - 6   2021

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.11241/jsmtmr.36.5

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  • Clinical benefit for clinical sequencing using cancer panel testing. Reviewed

    Nishimura S, Sugimoto A, Kushiyama S, Togano S, Kuroda K, Yamamoto Y, Yamauchi M, Sumi T, Kaneda H, Kawaguchi T, Kato M, Tagami M, Oebisu N, Hoshi M, Kimura K, Kubo S, Muguruma K, Takashima T, Ohira M, Yashiro M

    PloS one   16 ( 2 )   e0247090   2021

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1371/journal.pone.0247090

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  • Clinical benefit for clinical sequencing using cancer panel testing.

    Nishimura S, Sugimoto A, Kushiyama S, Togano S, Kuroda K, Yamamoto Y, Yamauchi M, Sumi T, Kaneda H, Kawaguchi T, Kato M, Tagami M, Oebisu N, Hoshi M, Kimura K, Kubo S, Muguruma K, Takashima T, Ohira M, Yashiro M

    PloS one   16 ( 2 )   e0247090   2021

  • Does clinical sequencing bridge to clinical benefit in cancer treatment?

    Nishimura Sadaaki, Sugimoto Atsushi, Kushiyama Shuhei, Togano Shingo, Kuroda Kenji, Yamauchi Makoto, Sumi Toshiyuki, Kaneda Hiroyasu, Kawaguchi Tomoya, Kato Minoru, Kimura Kenjiro, Nagahara Hisashi, Muguruma Kazuya, Lee Shigeru, Takashima Tsutomu, Kubo Shoji, Ohira Masaichi, Yashiro Masakazu

    Japan Journal of Molecular Tumor Marker Research   36 ( 0 )   5 - 6   2021( eISSN:24338575

  • Early-onset meningitis associated with atezolizumab treatment for non-small cell lung cancer: case report and literature review Reviewed

    Ogawa Koichi, Kaneda Hiroyasu, Kawamoto Tamaki, Tani Yoko, Izumi Motohiro, Matsumoto Yoshiya, Sawa Kenji, Suzumura Tomohiro, Watanabe Tetsuya, Mitsuoka Shigeki, Asai Kazuhisa, Kawaguchi Tomoya

    INVESTIGATIONAL NEW DRUGS   38 ( 6 )   1901 - 1905   2020.12( ISSN:0167-6997

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s10637-020-00947-w

    PubMed

  • A mouse model of rapidly progressive fatal haemorrhagic pneumonia caused by Stenotrophomonas maltophilia Reviewed

    Imoto Waki, Kaneko Yukihiro, Yamada Koichi, Kuwabara Gaku, Yamairi Kazushi, Shibata Wataru, Oshima Kazuhiro, Niki Makoto, Nakaie Kiyotaka, Watanabe Tetsuya, Asai Kazuhisa, Kawaguchi Tomoya, Kakeya Hiroshi

    JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE   23   450 - 455   2020.12( ISSN:2213-7165

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    DOI: 10.1016/j.jgar.2020.10.024

    PubMed

  • A mouse model of rapidly progressive fatal haemorrhagic pneumonia caused by Stenotrophomonas maltophilia.

    Imoto W, Kaneko Y, Yamada K, Kuwabara G, Yamairi K, Shibata W, Oshima K, Niki M, Nakaie K, Watanabe T, Asai K, Kawaguchi T, Kakeya H

    Journal of global antimicrobial resistance   23   450 - 455   2020.12( ISSN:2213-7165

  • Early-onset meningitis associated with atezolizumab treatment for non-small cell lung cancer: case report and literature review.

    Ogawa K, Kaneda H, Kawamoto T, Tani Y, Izumi M, Matsumoto Y, Sawa K, Suzumura T, Watanabe T, Mitsuoka S, Asai K, Kawaguchi T

    Investigational new drugs   38 ( 6 )   1901 - 1905   2020.12( ISSN:0167-6997

  • Detection of Rhizopus-specific antigen in human and murine serum and bronchoalveolar lavage.

    Shibata W, Niki M, Sato K, Fujimoto H, Yamada K, Watanabe T, Miyazaki Y, Asai K, Obata Y, Tachibana T, Kawaguchi T, Kaneko Y, Kakeya H

    Medical mycology   58 ( 7 )   958 - 964   2020.10( ISSN:1369-3786

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  • A Case Report of a Regressed Bronchial Granular Cell Tumor Followed by Bronchoscopy

    Kadotani Hideaki, Mamoto Takashi, Yamane Kenshi, Sawatari Kosuke, Tsuda Takanori, Sakagami Kazuki, Nagano Koshi, Kawaguchi Tomoya

    The Journal of the Japan Society for Respiratory Endoscopy   42 ( 5 )   414 - 417   2020.09( ISSN:02872137 ( eISSN:21860149

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    <p><b><i>Background.</i></b> Bronchial granular cell tumors (GCTs) are relatively rare. In most cases, the GCT is surgically resected, and cases of regression are extremely rare. <b><i>Case.</i></b> A 46-year-old man presented with recurrent pneumonia; therefore, bronchoscopy was performed to observe the central airway. At that time, an elevated white lesion was found at the orifice of the right B<sup>6</sup>. Following an open biopsy, we diagnosed GCT and planned surgical resection. However, the lesion regressed before the planned operation. Subsequently, it has remained regressed. <b><i>Conclusion.</i></b> The standard treatment for GCT is surgical resection. However, as in our case, regression may sometimes be observed. Therefore, careful judgement is required for the treatment of bronchial GCT.</p>

    DOI: 10.18907/jjsre.42.5_414

    CiNii Article

  • Can smoking duration alone replace pack-years to predict the risk of smoking-related oncogenic mutations in non-small cell lung cancer? A cross-sectional study in Japan.

    Ogawa K, Koh Y, Kaneda H, Izumi M, Matsumoto Y, Sawa K, Fukui M, Taniguchi Y, Yoshimoto N, Tamiya A, Ando M, Kubo A, Isa SI, Saka H, Matsumura A, Kawaguchi T

    BMJ open   10 ( 9 )   e035615   2020.09

  • Ninjin-yoeito ameliorates cigarette smoke-induced skeletal muscle complications in mice Reviewed

    Miyamoto Atsushi, Kadotani Hideaki, Asai Kazuhisa, Maruyama Naomi, Kubo Hiroaki, Okamoto Atsuko, Ijiri Naoki, Sato Kanako, Watanabe Tetsuya, Hirata Kazuto, Kawaguchi Tomoya

    EUROPEAN RESPIRATORY JOURNAL   56   2020.09( ISSN:0903-1936

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    DOI: 10.1183/13993003.congress-2020.189

  • Tracing the Coevolution Path of Supermassive Black Holes and Spheroids with AKARI-selected Ultraluminous IR Galaxies at Intermediate Redshifts

    Chen X.

    Astrophysical Journal   900 ( 1 )   2020.09( ISSN:0004637X

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  • 経過観察中に自然消退傾向を認めた気管支顆粒細胞腫の1例 Reviewed

    門谷 英昭, 眞本 卓司, 山根 健志, 佐渡 康介, 津田 誉至, 阪上 和樹, 永野 晃史, 川口 知哉

    (NPO)日本呼吸器内視鏡学会 気管支学   42 ( 5 )   414 - 417   2020.09( ISSN:0287-2137

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    背景.気管および気管支原発の顆粒細胞腫は稀であり、ほとんどの症例で外科的切除が施行されているが、経過観察中に自然消退傾向を認める症例は極めて稀である。症例.46歳男性。左下葉の肺炎を反復するため、中枢気道の精査目的に気管支鏡検査を施行したところ、偶発的に右下葉B6入口部に白色隆起性病変を認めた。直視下生検にて顆粒細胞腫と診断した。外科的切除を予定していたが、術前の気管支鏡検査で消退傾向を認めたため見送った。その後も定期的に気管支鏡検査を行っているが、消退傾向は続いている。結論.顆粒細胞腫の第一選択となる治療法は外科的切除であるが、本症例のように自然消退を認める場合もあり、治療に際しては慎重な判断が必要である。(著者抄録)

  • 経過観察中に自然消退傾向を認めた気管支顆粒細胞腫の1例

    門谷 英昭, 眞本 卓司, 山根 健志, 佐渡 康介, 津田 誉至, 阪上 和樹, 永野 晃史, 川口 知哉

    気管支学   42 ( 5 )   414 - 417   2020.09( ISSN:0287-2137

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    背景.気管および気管支原発の顆粒細胞腫は稀であり、ほとんどの症例で外科的切除が施行されているが、経過観察中に自然消退傾向を認める症例は極めて稀である。症例.46歳男性。左下葉の肺炎を反復するため、中枢気道の精査目的に気管支鏡検査を施行したところ、偶発的に右下葉B6入口部に白色隆起性病変を認めた。直視下生検にて顆粒細胞腫と診断した。外科的切除を予定していたが、術前の気管支鏡検査で消退傾向を認めたため見送った。その後も定期的に気管支鏡検査を行っているが、消退傾向は続いている。結論.顆粒細胞腫の第一選択となる治療法は外科的切除であるが、本症例のように自然消退を認める場合もあり、治療に際しては慎重な判断が必要である。(著者抄録)

  • The effect of intervention by an antimicrobial stewardship team on anaerobic bacteremia Reviewed

    Kuwabara Gaku, Yukawa Satomi, Yamada Koichi, Imoto Waki, Yamairi Kazushi, Shibata Wataru, Yoshii Naoko, Watanabe Tetsuya, Asai Kazuhisa, Niki Makoto, Nakaie Kiyotaka, Okada Yasuyo, Fujita Akiko, Kaneko Yukihiro, Kawaguchi Tomoya, Kakeya Hiroshi

    ANAEROBE   64   102214   2020.08( ISSN:1075-9964

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    DOI: 10.1016/j.anaerobe.2020.102214

    PubMed

  • Mutational landscape of multiple primary lung cancers and its correlation with environmental factors Reviewed

    Izumi Motohiro, Oyanagi Jun, Sawa Kenji, Fukui Mitsuru, Ogawa Koichi, Matsumoto Yoshiya, Tani Yoko, Suzumura Tomohiro, Watanabe Tetsuya, Kaneda Hiroyasu, Mitsuoka Shigeki, Asai Kazuhisa, Kimura Tatsuo, Yamamoto Nobuyuki, Kawaguchi Tomoya, Koh Yasuhiro

    CANCER RESEARCH   80 ( 16 )   2020.08( ISSN:0008-5472

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    DOI: 10.1158/1538-7445.AM2020-2333

  • Surveillance of Hepatocellular Carcinoma in Nonalcoholic Fatty Liver Disease

    Sumida Y.

    Diagnostics   10 ( 8 )   2020.08

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  • The effect of intervention by an antimicrobial stewardship team on anaerobic bacteremia.

    Kuwabara G, Yukawa S, Yamada K, Imoto W, Yamairi K, Shibata W, Yoshii N, Watanabe T, Asai K, Niki M, Nakaie K, Okada Y, Fujita A, Kaneko Y, Kawaguchi T, Kakeya H

    Anaerobe   64   102214   2020.08( ISSN:1075-9964

  • Ethnic difference in lung cancer: an important issue in a globalized society Reviewed

    Kawaguchi Tomoya, Mack Philip C.

    JOURNAL OF THORACIC DISEASE   12 ( 7 )   3774 - 3775   2020.07( ISSN:2072-1439

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.21037/jtd.2020.01.57

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  • Differences in molecular epidemiology of lung cancer among ethnicities (Asian vs. Caucasian) Reviewed

    Izumi Motohiro, Suzumura Tomohiro, Ogawa Koichi, Matsumoto Yoshiya, Sawa Kenji, Yoshimoto Naoki, Tani Yoko, Watanabe Tetsuya, Kaneda Hiroyasu, Mitsuoka Shigeki, Asai Kazuhisa, Kawaguchi Tomoya

    JOURNAL OF THORACIC DISEASE   12 ( 7 )   3776 - +   2020.07( ISSN:2072-1439

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.21037/jtd.2019.08.61

    PubMed

  • Differences in molecular epidemiology of lung cancer among ethnicities (Asian <i>vs.</i> Caucasian).

    Izumi M, Suzumura T, Ogawa K, Matsumoto Y, Sawa K, Yoshimoto N, Tani Y, Watanabe T, Kaneda H, Mitsuoka S, Asai K, Kawaguchi T

    Journal of thoracic disease   12 ( 7 )   3776 - 3784   2020.07( ISSN:2072-1439

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  • Ethnic difference in lung cancer: an important issue in a globalized society.

    Kawaguchi T, Mack PC

    Journal of thoracic disease   12 ( 7 )   3774 - 3775   2020.07( ISSN:2072-1439

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  • DisseminatedMycobacterium abscessussubsp.massilienseinfection in a Good's syndrome patient negative for human immunodeficiency virus and anti-interferon-gamma autoantibody: a case report Reviewed

    Imoto Waki, Yamada Koichi, Hajika Yuriko, Okamoto Kousuke, Myodo Yuka, Niki Makoto, Kuwabara Gaku, Yamairi Kazushi, Shibata Wataru, Yoshii Naoko, Nakaie Kiyotaka, Yoshizawa Kazutaka, Namikawa Hiroki, Watanabe Tetsuya, Asai Kazuhisa, Moro Hiroshi, Kaneko Yukihiro, Kawaguchi Tomoya, Itoh Yoshiaki, Kakeya Hiroshi

    BMC INFECTIOUS DISEASES   20 ( 1 )   431   2020.06

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    DOI: 10.1186/s12879-020-05136-x

    PubMed

  • Disseminated Mycobacterium abscessus subsp. massiliense infection in a Good's syndrome patient negative for human immunodeficiency virus and anti-interferon-γ autoantibody: a case report.

    Imoto W, Yamada K, Hajika Y, Okamoto K, Myodo Y, Niki M, Kuwabara G, Yamairi K, Shibata W, Yoshii N, Nakaie K, Yoshizawa K, Namikawa H, Watanabe T, Asai K, Moro H, Kaneko Y, Kawaguchi T, Itoh Y, Kakeya H

    BMC infectious diseases   20 ( 1 )   431   2020.06

  • 臨床診療のA型インフルエンザ患者に対するバロキサビルとノイラミニダーゼ阻害薬の有効性の比較(The Comparison of the Efficacy of Baloxavir and Neuraminidase Inhibitors for Patients with Influenza A in Clinical Practice) Reviewed

    Yoshii Naoko, Tochino Yoshihiro, Fujioka Masashi, Sakazaki Hiromi, Maruyama Naomi, Asai Kazuhisa, Kakeya Hiroshi, Shintaku Haruo, Kawaguchi Tomoya

    (一社)日本内科学会 Internal Medicine   59 ( 12 )   1509 - 1513   2020.06( ISSN:0918-2918

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    臨床診療のA型インフルエンザ患者において、バロキサビルとノイラミニダーゼ阻害薬(NAI)の有効性を比較した。2018〜2019年のインフルエンザシーズンに大阪府の50施設でバロキサビルまたはNAIが処方された患者900例を対象に郵送による質問票調査を行い、A型インフルエンザ患者295例のデータを解析した。バロキサビル投与患者は111例(男性50例、女性60例、性別不明1例、2〜72歳)、NAI投与患者は184例(男性73例、女性108例、性別不明3例、0〜91歳)であった。多変量調整後、2日以内の発熱緩和の関連因子は、バロキサビル治療、発症から治療開始までの期間≧2.5日であった。バロキサビル投与患者はNAI投与患者に比し、発熱緩和までの期間が有意に短縮した(1.94±0.09 vs.2.35±0.08日)。臨床診療のA型インフルエンザ患者において、バロキサビルはNAIよりも有効性が高いことが示された。

  • 臨床診療のA型インフルエンザ患者に対するバロキサビルとノイラミニダーゼ阻害薬の有効性の比較(The Comparison of the Efficacy of Baloxavir and Neuraminidase Inhibitors for Patients with Influenza A in Clinical Practice)

    Yoshii Naoko, Tochino Yoshihiro, Fujioka Masashi, Sakazaki Hiromi, Maruyama Naomi, Asai Kazuhisa, Kakeya Hiroshi, Shintaku Haruo, Kawaguchi Tomoya

    Internal Medicine   59 ( 12 )   1509 - 1513   2020.06( ISSN:0918-2918

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    臨床診療のA型インフルエンザ患者において、バロキサビルとノイラミニダーゼ阻害薬(NAI)の有効性を比較した。2018〜2019年のインフルエンザシーズンに大阪府の50施設でバロキサビルまたはNAIが処方された患者900例を対象に郵送による質問票調査を行い、A型インフルエンザ患者295例のデータを解析した。バロキサビル投与患者は111例(男性50例、女性60例、性別不明1例、2〜72歳)、NAI投与患者は184例(男性73例、女性108例、性別不明3例、0〜91歳)であった。多変量調整後、2日以内の発熱緩和の関連因子は、バロキサビル治療、発症から治療開始までの期間≧2.5日であった。バロキサビル投与患者はNAI投与患者に比し、発熱緩和までの期間が有意に短縮した(1.94±0.09 vs.2.35±0.08日)。臨床診療のA型インフルエンザ患者において、バロキサビルはNAIよりも有効性が高いことが示された。

  • Annual lung cancer screening by chest X ray to avoid further examinations. Reviewed

    Kimura Tatsuo, Fukumoto Shinya, Fujii Hideki, Nakano Akemi, Nadatani Yuji, Tauchi Yukie, Suzumura Tomohiro, Ogawa Koichi, Kawaguchi Tomoya, Kawada Norifumi

    JOURNAL OF CLINICAL ONCOLOGY   38 ( 15 )   2020.05( ISSN:0732-183X

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  • The impact of estrogen receptor status on EGFR/TP53/CTNNB1 axis in the evolution of non-small cell lung cancer. Reviewed

    Tani Yoko, Koh Yasuhiro, Tamiya Akihiro, Isa Shun-ichi, Kubo Akihito, Ando Masahiko, Saka Hideo, Izumi Motohiro, Ogawa Koichi, Matsumoto Yoshiya, Sawa Kenji, Yoshimoto Naoki, Suzumura Tomohiro, Watanabe Tetsuya, Kaneda Hiroyasu, Mitsuoka Shigeki, Asai Kazuhisa, Kawaguchi Tomoya

    JOURNAL OF CLINICAL ONCOLOGY   38 ( 15 )   2020.05( ISSN:0732-183X

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  • RELAY plus : Exploratory study of ramucirumab plus gefitinib in untreated patients (pts) with epidermal growth factor receptor (EGFR)-mutated metastatic non-small cell lung cancer (NSCLC). Reviewed

    Nishio Makoto, Nishio Kazuto, Reck Martin, Garon Edward B., Imamura Fumio, Kawaguchi Tomoya, Yamaguchi Hiroyuki, Ikeda Satoshi, Hirano Katsuya, Visseren-Grul Carla M., Widau Ryan C., Zimmermann Annamaria H., Homma Gosuke, Enatsu Sotaro, Nakagawa Kazuhiko

    JOURNAL OF CLINICAL ONCOLOGY   38 ( 15 )   2020.05( ISSN:0732-183X

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  • Impact of somatic mutations on prognosis in resected non-small-cell lung cancer: The Japan Molecular Epidemiology for lung cancer study.

    Tamiya A, Koh Y, Isa SI, Kubo A, Ando M, Saka H, Yoshimoto N, Takeo S, Adachi H, Tagawa T, Kawashima O, Yamashita M, Kataoka K, Takenoyama M, Takeuchi Y, Watanabe K, Matsumura A, Kawaguchi T

    Cancer medicine   9 ( 7 )   2343 - 2351   2020.04

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  • Development of a half-cell for x-ray structural analysis of liquid electrolytes in rechargeable batteries. Reviewed

    Kimura K, Kiuchi H, Morita M, Kawaguchi T, Yoshii K, Sakaebe H, Hayashi K

    The Review of scientific instruments   91 ( 3 )   033907   2020.03( ISSN:0034-6748

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    DOI: 10.1063/1.5124797

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  • Development of a half-cell for x-ray structural analysis of liquid electrolytes in rechargeable batteries.

    Kimura K, Kiuchi H, Morita M, Kawaguchi T, Yoshii K, Sakaebe H, Hayashi K

    The Review of scientific instruments   91 ( 3 )   033907   2020.03( ISSN:0034-6748

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  • Detection of Rhizopus-specific antigen in human and murine serum and bronchoalveolar lavage. Reviewed

    Shibata W, Niki M, Sato K, Fujimoto H, Yamada K, Watanabe T, Miyazaki Y, Asai K, Obata Y, Tachibana T, Kawaguchi T, Kaneko Y, Kakeya H

    Medical mycology   2020.02( ISSN:1369-3786

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/mmy/myaa001

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  • Impact of somatic mutations on prognosis in resected non-small-cell lung cancer: The Japan Molecular Epidemiology for lung cancer study Reviewed

    Tamiya Akihiro, Koh Yasuhiro, Isa Shun-ichi, Kubo Akihito, Ando Masahiko, Saka Hideo, Yoshimoto Naoki, Takeo Sadanori, Adachi Hirofumi, Tagawa Tsutomu, Kawashima Osamu, Yamashita Motohiro, Kataoka Kazuhiko, Takenoyama Mitsuhiro, Takeuchi Yukiyasu, Watanabe Katsuya, Matsumura Akihide, Kawaguchi Tomoya

    CANCER MEDICINE   2020.02( ISSN:2045-7634

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    DOI: 10.1002/cam4.2897

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  • 外来化学療法を受ける患者の自己管理への支援 治療日記を導入して Reviewed

    本城 智子, 岩見 明子, 井上 加津子, 中野 妙子, 山添 定明, 川口 知哉

    (株)癌と化学療法社 癌と化学療法   47 ( 2 )   263 - 266   2020.02( ISSN:0385-0684

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    外来化学療法を安全に実施するためには、患者が体調を自己管理しながら治療に参加することが重要で、医療者は患者が自己管理できるように支援する役割がある。そのために、自記式の化学療法治療日記を作成し導入したことで、患者の自己管理への支援となり、自ら治療に参加する動機付けとなった。(著者抄録)

  • [Assistance for Self-Management of Outpatient Chemotherapy-Introduction of Medical Treatment Diary]. Reviewed

    Honjo T, Iwami A, Inoue K, Nakano T, Yamazoe S, Kawaguchi T

    Gan to kagaku ryoho. Cancer & chemotherapy   47 ( 2 )   263 - 266   2020.02( ISSN:0385-0684

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    PubMed

  • [Assistance for Self-Management of Outpatient Chemotherapy-Introduction of Medical Treatment Diary].

    Honjo T, Iwami A, Inoue K, Nakano T, Yamazoe S, Kawaguchi T

    Gan to kagaku ryoho. Cancer & chemotherapy   47 ( 2 )   263 - 266   2020.02( ISSN:0385-0684

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  • 外来化学療法を受ける患者の自己管理への支援 治療日記を導入して

    本城 智子, 岩見 明子, 井上 加津子, 中野 妙子, 山添 定明, 川口 知哉

    癌と化学療法   47 ( 2 )   263 - 266   2020.02( ISSN:0385-0684

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    外来化学療法を安全に実施するためには、患者が体調を自己管理しながら治療に参加することが重要で、医療者は患者が自己管理できるように支援する役割がある。そのために、自記式の化学療法治療日記を作成し導入したことで、患者の自己管理への支援となり、自ら治療に参加する動機付けとなった。(著者抄録)

  • Effect of four neuraminidase inhibitors on influenza in Osaka, Japan: An eight-year survey(和訳中) Reviewed

    Tochino Yoshihiro, Yoshii Naoko, Fujioka Masashi, Hamazaki Takashi, Kawaguchi Tomoya, Kakeya Hiroshi, Shuto Taichi

    (一社)日本プライマリ・ケア連合学会 Journal of General and Family Medicine   21 ( 1 )   18 - 23   2020.01( ISSN:2189-6577

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  • Clinical Characteristics of Rapidly Progressive Fatal Hemorrhagic Pneumonia Caused by Stenotrophomonas maltophilia(和訳中) Reviewed

    Imoto Waki, Yamada Koichi, Yamairi Kazushi, Shibata Wataru, Namikawa Hiroki, Yukawa Satomi, Yoshii Naoko, Nakaie Kiyotaka, Hirose Asao, Koh Hideo, Watanabe Tetsuya, Asai Kazuhisa, Nakamae Hirohisa, Kaneko Yukihiro, Kawaguchi Tomoya, Hino Masayuki, Kakeya Hiroshi

    (一社)日本内科学会 Internal Medicine   59 ( 2 )   193 - 198   2020.01( ISSN:0918-2918

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  • Predictive impact of low-frequency pretreatment T790M mutation in patients with EGFR-mutated non-small cell lung cancer treated with EGFR tyrosine kinase inhibitors Reviewed

    Matsumoto Yoshiya, Sawa Kenji, Fukui Mitsuru, Oyanagi Jun, Yoshimoto Naoki, Suzumura Tomohiro, Watanabe Tetsuya, Kaneda Hiroyasu, Mitsuoka Shigeki, Asai Kazuhisa, Kimura Tatsuo, Yamamoto Nobuyuki, Hirata Kazuto, Koh Yasuhiro, Kawaguchi Tomoya

    LUNG CANCER   139   80 - 88   2020.01( ISSN:0169-5002

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.lungcan.2019.10.029

    PubMed

  • Effect of four neuraminidase inhibitors on influenza in Osaka, Japan: An eight-year survey Reviewed

    Tochino Yoshihiro, Yoshii Naoko, Fujioka Masashi, Hamazaki Takashi, Kawaguchi Tomoya, Kakeya Hiroshi, Shuto Taichi

    JOURNAL OF GENERAL AND FAMILY MEDICINE   21 ( 1 )   18 - 23   2020.01( ISSN:2189-7948

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/jgf2.286

    PubMed

  • Effect of four neuraminidase inhibitors on influenza in Osaka, Japan: An eight-year survey.

    Tochino Y, Yoshii N, Fujioka M, Hamazaki T, Kawaguchi T, Kakeya H, Shuto T

    Journal of general and family medicine   21 ( 1 )   18 - 23   2020.01( ISSN:2189-6577

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  • 大阪におけるインフルエンザに対する4種類のノイラミニダーゼ阻害剤の効果 8年間の調査(Effect of four neuraminidase inhibitors on influenza in Osaka, Japan: An eight-year survey)

    Tochino Yoshihiro, Yoshii Naoko, Fujioka Masashi, Hamazaki Takashi, Kawaguchi Tomoya, Kakeya Hiroshi, Shuto Taichi

    Journal of General and Family Medicine   21 ( 1 )   18 - 23   2020.01( ISSN:2189-6577

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    ノイラミニダーゼ阻害剤(NAI)であるラニナミビル、ペラミビル、オセルタミビル、ザナミビルの処方傾向を8年にわたって調べ、インフルエンザに関連する臨床データを評価した。インフルエンザと診断された患者に対しアンケート調査を依頼し、人口統計学的特徴、発熱などの症状、処方薬、インフルエンザの種類に関するデータを収集した。その結果、ラニナミビルは10歳以上の患者に最も処方され、オセルタミビルは10歳未満の患者に最も処方されていた。4種類のNAIはいずれもインフルエンザに対して同様の効果を示した。A型インフルエンザの患者はB型インフルエンザの患者よりも早く熱が下がった。高齢患者は発熱時の体温が低い傾向があった。ほとんどの季節で同様の結果となった。

  • Predictive impact of low-frequency pretreatment T790M mutation in patients with EGFR-mutated non-small cell lung cancer treated with EGFR tyrosine kinase inhibitors.

    Matsumoto Y, Sawa K, Fukui M, Oyanagi J, Yoshimoto N, Suzumura T, Watanabe T, Kaneda H, Mitsuoka S, Asai K, Kimura T, Yamamoto N, Hirata K, Koh Y, Kawaguchi T

    Lung cancer (Amsterdam, Netherlands)   139   80 - 88   2020.01( ISSN:0169-5002

  • Stenotrophomonas maltophiliaにより引き起こされた急速進行性致死性出血性肺炎の臨床的特徴(Clinical Characteristics of Rapidly Progressive Fatal Hemorrhagic Pneumonia Caused by Stenotrophomonas maltophilia)

    Imoto Waki, Yamada Koichi, Yamairi Kazushi, Shibata Wataru, Namikawa Hiroki, Yukawa Satomi, Yoshii Naoko, Nakaie Kiyotaka, Hirose Asao, Koh Hideo, Watanabe Tetsuya, Asai Kazuhisa, Nakamae Hirohisa, Kaneko Yukihiro, Kawaguchi Tomoya, Hino Masayuki, Kakeya Hiroshi

    Internal Medicine   59 ( 2 )   193 - 198   2020.01( ISSN:0918-2918

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    Stenotrophomonas maltophilia(SM)菌血症で入院した35例の医療データを用いて、SMによる出血性肺炎の予測因子を後向きに評価した。4例(男性3例、女性1例、中央値56.2歳)で出血性肺炎を認め、31例(男性19例、女性12例、中央値59.5歳)は出血性肺炎を認めなかった。出血性肺炎を認めた患者は認めなかった患者に比べて悪性血液疾患の割合が有意に高く(100 vs 38.7%)、血小板減少症の割合が有意に高く(100 vs 38.7%)、30日以内のキノロン系薬使用率が有意に高かった(75 vs 19.4%)。入院中の死亡率は、出血性肺炎を認めた患者100%、認めなかった患者32.3%であった(p=0.02)。悪性血液疾患、血小板減少症、30日以内のキノロン系薬使用歴のあるSM菌血症患者では慎重に治療を行う必要があることが示された。

  • A Case Report of a Regressed Bronchial Granular Cell Tumor Followed by Bronchoscopy Reviewed

    Kadotani Hideaki, Mamoto Takashi, Yamane Kenshi, Sawatari Kosuke, Tsuda Takanori, Sakagami Kazuki, Nagano Koshi, Kawaguchi Tomoya

    The Japan Society for Respiratory Endoscopy, The Journal of the Japan Society for Respiratory Endoscopy   42 ( 5 )   414 - 417   2020( ISSN:0287-2137

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    Publishing type:Research paper (scientific journal)  

    <p><b><i>Background.</i></b> Bronchial granular cell tumors (GCTs) are relatively rare. In most cases, the GCT is surgically resected, and cases of regression are extremely rare. <b><i>Case.</i></b> A 46-year-old man presented with recurrent pneumonia; therefore, bronchoscopy was performed to observe the central airway. At that time, an elevated white lesion was found at the orifice of the right B<sup>6</sup>. Following an open biopsy, we diagnosed GCT and planned surgical resection. However, the lesion regressed before the planned operation. Subsequently, it has remained regressed. <b><i>Conclusion.</i></b> The standard treatment for GCT is surgical resection. However, as in our case, regression may sometimes be observed. Therefore, careful judgement is required for the treatment of bronchial GCT.</p>

    DOI: 10.18907/jjsre.42.5_414

    CiNii Article

  • The Comparison of the Efficacy of Baloxavir and Neuraminidase Inhibitors for Patients with Influenza A in Clinical Practice Reviewed

    Yoshii Naoko, Tochino Yoshihiro, Fujioka Masashi, Sakazaki Hiromi, Maruyama Naomi, Asai Kazuhisa, Kakeya Hiroshi, Shintaku Haruo, Kawaguchi Tomoya

    一般社団法人 日本内科学会 INTERNAL MEDICINE   59 ( 12 )   1509 - 1513   2020( ISSN:0918-2918

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    Publishing type:Research paper (scientific journal)  

    <p><b>Objective </b>Baloxavir marboxil is a novel anti-influenza drug reported to have an early antiviral effect, although it also causes the appearance of variant viruses with a reduced susceptibility to baloxavir. In Japan, four neuraminidase inhibitors (NAIs) have been commonly used to treat patients with influenza. In clinical practice, the differences in the effects of baloxavir and NAIs have not been sufficiently examined. Our objective was to clarify the clinical differences in efficacy between baloxavir and NAIs. </p><p><b>Methods </b>A multicenter, observational study was conducted using postcard questionnaires during the 2018-19 influenza season. Patients who were prescribed anti-influenza drugs were provided postcard questionnaires asking about their background characteristics and their body temperatures. The factors associated with the early alleviation of the fever were analyzed, and the duration of the fever was compared between the baloxavir group and the NAI group. </p><p><b>Results </b>A total of 295 patients with influenza A, ranging in age from 0-91 years old, were enrolled in this study. A multivariate analysis showed that treatment with baloxavir and a duration from the onset to the start of treatment ≥2.5 days were factors contributing to the early alleviation of the fever from the start of treatment. The duration of the fever was significantly shorter in the baloxavir group than in the NAI group (p=0.002). </p><p><b>Conclusion </b>The present survey showed that baloxavir was significantly more effective than NAIs for treating patients with influenza A in clinical practice. </p>

    DOI: 10.2169/internalmedicine.4117-19

    PubMed

    CiNii Article

  • Ninjin'yoeito Ameliorates Skeletal Muscle Complications in COPD Model Mice by Upregulating Peroxisome Proliferator-Activated Receptor gamma Coactivator-1 alpha Expression Reviewed

    Miyamoto Atsushi, Asai Kazuhisa, Kadotani Hideaki, Maruyama Naomi, Kubo Hiroaki, Okamoto Atsuko, Sato Kanako, Yamada Kazuhiro, Ijiri Naoki, Watanabe Tetsuya, Kawaguchi Tomoya

    INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE   15   3063 - 3077   2020( ISSN:1178-2005

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.2147/COPD.S280401

    PubMed

  • Can smoking duration alone replace pack-years to predict the risk of smoking-related oncogenic mutations in non-small cell lung cancer? A cross-sectional study in Japan Reviewed

    Ogawa Koichi, Koh Yasuhiro, Kaneda Hiroyasu, Izumi Motohiro, Matsumoto Yoshiya, Sawa Kenji, Fukui Mitsuru, Taniguchi Yoshihiko, Yoshimoto Naoki, Tamiya Akihiro, Ando Masahiko, Kubo Akihito, Isa Shun-ichi, Saka Hideo, Matsumura Akihide, Kawaguchi Tomoya

    BMJ OPEN   10 ( 9 )   e035615   2020( ISSN:2044-6055

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1136/bmjopen-2019-035615

    PubMed

  • Astaxanthin Suppresses Cigarette Smoke-Induced Emphysema Through Nrf2 Activation in Mice Reviewed

    Kubo H., Asai K., Iwasaki K., Kawai T., Nishimura M., Maruyama N., Kadotani H., Miyamoto A., Okamoto A., Sato K., Yamada K., Ijiri N., Watanabe T., Hirata K., Kawaguchi T.

    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE   201   2020( ISSN:1073-449X

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  • Clinical Characteristics of Rapidly Progressive Fatal Hemorrhagic Pneumonia Caused by Stenotrophomonas maltophilia Reviewed

    Imoto Waki, Yamada Koichi, Yamairi Kazushi, Shibata Wataru, Namikawa Hiroki, Yukawa Satomi, Yoshii Naoko, Nakaie Kiyotaka, Hirose Asao, Koh Hideo, Watanabe Tetsuya, Asai Kazuhisa, Nakamae Hirohisa, Kaneko Yukihiro, Kawaguchi Tomoya, Hino Masayuki, Kakeya Hiroshi

    一般社団法人 日本内科学会 INTERNAL MEDICINE   59 ( 2 )   193 - 198   2020( ISSN:0918-2918

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    Publishing type:Research paper (scientific journal)  

    <p><b>Objective </b>Hemorrhagic pneumonia due to <i>Stenotrophomonas maltophilia</i> (SM) in severely immunocompromised patients has a very poor prognosis. However, the risk factors for hemorrhagic pneumonia are not clear. </p><p><b>Methods </b>This study assessed the predictive factors of hemorrhagic pneumonia caused by SM. The medical records of patients admitted to Osaka City University Hospital with SM bacteremia between January 2008 and December 2017 were retrospectively reviewed. </p><p><b>Patients </b>All patients who had positive blood cultures for SM were included in this study. They were categorized into two groups: the SM bacteremia with hemorrhagic pneumonia group and the SM bacteremia without hemorrhagic pneumonia group. The clinical background characteristics and treatments were compared between these groups. </p><p><b>Results </b>The 35 patients with SM bacteremia included 4 with hemorrhagic pneumonia and 31 without hemorrhagic pneumonia. Hematologic malignancy (p=0.03) and thrombocytopenia (p=0.04) as well as the prior use of quinolone within 30 days (p=0.04) were more frequent in the SM bacteremia patients with hemorrhagic pneumonia than in those without hemorrhagic pneumonia. The mortality of the SM bacteremia patients with hemorrhagic pneumonia was higher than that of those without hemorrhagic pneumonia group (p=0.02). </p><p><b>Conclusion </b>Patients with SM bacteremia who have hematologic malignancy, thrombocytopenia, and a history of using quinolone within the past 30 days should be treated with deliberation. </p>

    DOI: 10.2169/internalmedicine.3358-19

    PubMed

    CiNii Article

  • Clinical Characteristics of Rapidly Progressive Fatal Hemorrhagic Pneumonia Caused by <i>Stenotrophomonas maltophilia</i>

    Imoto Waki, Yamada Koichi, Yamairi Kazushi, Shibata Wataru, Namikawa Hiroki, Yukawa Satomi, Yoshii Naoko, Nakaie Kiyotaka, Hirose Asao, Koh Hideo, Watanabe Tetsuya, Asai Kazuhisa, Nakamae Hirohisa, Kaneko Yukihiro, Kawaguchi Tomoya, Hino Masayuki, Kakeya Hiroshi

    Internal Medicine   59 ( 2 )   193 - 198   2020( ISSN:0918-2918 ( eISSN:13497235

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    <p><b>Objective </b>Hemorrhagic pneumonia due to <i>Stenotrophomonas maltophilia</i> (SM) in severely immunocompromised patients has a very poor prognosis. However, the risk factors for hemorrhagic pneumonia are not clear. </p><p><b>Methods </b>This study assessed the predictive factors of hemorrhagic pneumonia caused by SM. The medical records of patients admitted to Osaka City University Hospital with SM bacteremia between January 2008 and December 2017 were retrospectively reviewed. </p><p><b>Patients </b>All patients who had positive blood cultures for SM were included in this study. They were categorized into two groups: the SM bacteremia with hemorrhagic pneumonia group and the SM bacteremia without hemorrhagic pneumonia group. The clinical background characteristics and treatments were compared between these groups. </p><p><b>Results </b>The 35 patients with SM bacteremia included 4 with hemorrhagic pneumonia and 31 without hemorrhagic pneumonia. Hematologic malignancy (p=0.03) and thrombocytopenia (p=0.04) as well as the prior use of quinolone within 30 days (p=0.04) were more frequent in the SM bacteremia patients with hemorrhagic pneumonia than in those without hemorrhagic pneumonia. The mortality of the SM bacteremia patients with hemorrhagic pneumonia was higher than that of those without hemorrhagic pneumonia group (p=0.02). </p><p><b>Conclusion </b>Patients with SM bacteremia who have hematologic malignancy, thrombocytopenia, and a history of using quinolone within the past 30 days should be treated with deliberation. </p>

    DOI: 10.2169/internalmedicine.3358-19

    PubMed

    CiNii Article

  • The Comparison of the Efficacy of Baloxavir and Neuraminidase Inhibitors for Patients with Influenza A in Clinical Practice

    Yoshii Naoko, Tochino Yoshihiro, Fujioka Masashi, Sakazaki Hiromi, Maruyama Naomi, Asai Kazuhisa, Kakeya Hiroshi, Shintaku Haruo, Kawaguchi Tomoya

    Internal Medicine   59 ( 12 )   1509 - 1513   2020( ISSN:0918-2918 ( eISSN:13497235

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    <p><b>Objective </b>Baloxavir marboxil is a novel anti-influenza drug reported to have an early antiviral effect, although it also causes the appearance of variant viruses with a reduced susceptibility to baloxavir. In Japan, four neuraminidase inhibitors (NAIs) have been commonly used to treat patients with influenza. In clinical practice, the differences in the effects of baloxavir and NAIs have not been sufficiently examined. Our objective was to clarify the clinical differences in efficacy between baloxavir and NAIs. </p><p><b>Methods </b>A multicenter, observational study was conducted using postcard questionnaires during the 2018-19 influenza season. Patients who were prescribed anti-influenza drugs were provided postcard questionnaires asking about their background characteristics and their body temperatures. The factors associated with the early alleviation of the fever were analyzed, and the duration of the fever was compared between the baloxavir group and the NAI group. </p><p><b>Results </b>A total of 295 patients with influenza A, ranging in age from 0-91 years old, were enrolled in this study. A multivariate analysis showed that treatment with baloxavir and a duration from the onset to the start of treatment ≥2.5 days were factors contributing to the early alleviation of the fever from the start of treatment. The duration of the fever was significantly shorter in the baloxavir group than in the NAI group (p=0.002). </p><p><b>Conclusion </b>The present survey showed that baloxavir was significantly more effective than NAIs for treating patients with influenza A in clinical practice. </p>

    DOI: 10.2169/internalmedicine.4117-19

    PubMed

    CiNii Article

  • Ninjin'yoeito Ameliorates Skeletal Muscle Complications in COPD Model Mice by Upregulating Peroxisome Proliferator-Activated Receptor γ Coactivator-1α Expression.

    Miyamoto A, Asai K, Kadotani H, Maruyama N, Kubo H, Okamoto A, Sato K, Yamada K, Ijiri N, Watanabe T, Kawaguchi T

    International journal of chronic obstructive pulmonary disease   15   3063 - 3077   2020( ISSN:1176-9106

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  • Sub-arcsecond to micro-arcsecond x-ray imaging with Multi Image X-ray Interferometer Method (MIXIM): Concept and scalable mission plans

    Hayashida K.

    Proceedings of SPIE - The International Society for Optical Engineering   11444   2020( ISSN:0277786X ( ISBN:9781510636750

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  • Astaxanthin Suppresses Cigarette Smoke-Induced Emphysema through Nrf2 Activation in Mice Reviewed

    Kubo Hiroaki, Asai Kazuhisa, Kojima Kazuya, Sugitani Arata, Kyomoto Yohkoh, Okamoto Atsuko, Yamada Kazuhiro, Ijiri Naoki, Watanabe Tetsuya, Hirata Kazuto, Kawaguchi Tomoya

    MARINE DRUGS   17 ( 12 )   2019.12

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.3390/md17120673

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  • Astaxanthin Suppresses Cigarette Smoke-Induced Emphysema through Nrf2 Activation in Mice.

    Kubo H, Asai K, Kojima K, Sugitani A, Kyomoto Y, Okamoto A, Yamada K, Ijiri N, Watanabe T, Hirata K, Kawaguchi T

    Marine drugs   17 ( 12 )   2019.11

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  • ISOFLAVONE AGLYCONES ATTENUATE CIGARETTE SMOKE-INDUCED EMPHYSEMA VIA SUPPRESSION OF NEUTROPHILIC INFLAMMATION IN A COPD MURINE MODEL Reviewed

    Kojima Kazuya, Asai Kazuhisa, Sugitani Arata, Kubo Hiroaki, Yamada Kazuhiro, Ijiri Naoki, Watanabe Tetsuya, Hirata Kazuto, Kawaguchi Tomoya

    RESPIROLOGY   24   161 - 161   2019.11( ISSN:1323-7799

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  • LNCRNA NEAT1 REGULATES IL-6 AND IL-8 MRNA EXPRESSION IN LUNG EPITHELIAL CELLS STIMULATED BY CIGARETTE SMOKE Reviewed

    Ijiri Naoki, Asai Kazuhisa, Tohda Mitsunori, Nakai Toshiyuki, Sato Kanako, Yamamoto Norio, Watanabe Tetsuya, Hirata Kazuto, Kawaguchi Tomoya

    RESPIROLOGY   24   161 - 161   2019.11( ISSN:1323-7799

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  • A Polymorphism rs6726395 in Nrf2 Contributes to the Development of Emphysema-Associated Age in Smokers Without COPD

    Sugitani A.

    Lung   197 ( 5 )   559 - 564   2019.10( ISSN:03412040

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  • SILVERRUSH. VIII. Spectroscopic Identifications of Early Large-scale Structures with Protoclusters over 200 Mpc at z ∼ 6-7: Strong Associations of Dusty Star-forming Galaxies

    Harikane Y.

    Astrophysical Journal   883 ( 2 )   2019.10( ISSN:0004637X

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  • Phase I/II study of intermitted erlotinib in combination with docetaxel in patients with recurrent non-small cell lung cancer (WJOG4708L).

    Kimura T, Kawaguchi T, Chiba Y, Yoshioka H, Watanabe K, Kijima T, Kogure Y, Oguri T, Yoshimura N, Niwa T, Kasai T, Hayashi H, Ono A, Asai K, Tanaka H, Yano S, Yamamoto N, Nakanishi Y, Nakagawa K

    Japanese journal of clinical oncology   49 ( 10 )   947 - 955   2019.10( ISSN:0368-2811

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  • Impact of tumor microenvironment on the efficacy of epidermal growth factor receptor-tyrosine kinase inhibitors in patients with EGFR-mutant non-small cell lung cancer Reviewed

    Matsumoto Yoshiya, Sawa Kenji, Fukui Mitsuru, Oyanagi Jun, Izumi Motohiro, Ogawa Koichi, Suzumura Tomohiro, Watanabe Tetsuya, Kaneda Hiroyasu, Mitsuoka Shigeki, Asai Kazuhisa, Kimura Tatsuo, Yamamoto Nobuyuki, Koh Yasuhiro, Kawaguchi Tomoya

    CANCER SCIENCE   110 ( 10 )   3244 - 3254   2019.10( ISSN:1347-9032

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/cas.14156

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  • Phase I/II study of intermitted erlotinib in combination with docetaxel in patients with recurrent non-small cell lung cancer (WJOG4708L)(和訳中) Reviewed

    Kimura Tatsuo, Kawaguchi Tomoya, Chiba Yasutaka, Yoshioka Hiroshige, Watanabe Katsuya, Kijima Takashi, Kogure Yoshihito, Oguri Tetsuya, Yoshimura Naruo, Niwa Takashi, Kasai Takashi, Hayashi Hidetoshi, Ono Akira, Asai Kazuhisa, Tanaka Hiroshi, Yano Seiji, Yamamoto Nobuyuki, Nakanishi Yoichi, Nakagawa Kazuhiko

    Oxford University Press Japanese Journal of Clinical Oncology   49 ( 10 )   947 - 955   2019.10( ISSN:0368-2811

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  • Impact of tumor microenvironment on the efficacy of epidermal growth factor receptor-tyrosine kinase inhibitors in patients with EGFR-mutant non-small cell lung cancer(和訳中) Reviewed

    Matsumoto Yoshiya, Sawa Kenji, Fukui Mitsuru, Oyanagi Jun, Izumi Motohiro, Ogawa Koichi, Suzumura Tomohiro, Watanabe Tetsuya, Kaneda Hiroyasu, Mitsuoka Shigeki, Asai Kazuhisa, Kimura Tatsuo, Yamamoto Nobuyuki, Koh Yasuhiro, Kawaguchi Tomoya

    John Wiley & Sons Australia, Ltd Cancer Science   110 ( 10 )   3244 - 3254   2019.10( ISSN:1347-9032

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  • A Polymorphism rs6726395 in Nrf2 Contributes to the Development of Emphysema-Associated Age in Smokers Without COPD Reviewed

    Sugitani A., Asai K., Watanabe T., Suzumura T., Kojima K., Kubo H., Sato K., Ijiri N., Yamada K., Kimura T., Fukumoto S., Hirata K., Kawaguchi T.

    LUNG   197 ( 5 )   559 - 564   2019.10( ISSN:0341-2040

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00408-019-00251-2

  • 再発非小細胞肺癌患者に対してドセタキセル投与に加えてエルロチニブを断続的に投与する第I/II相臨床試験(WJOG4708L)(Phase I/II study of intermitted erlotinib in combination with docetaxel in patients with recurrent non-small cell lung cancer (WJOG4708L))

    Kimura Tatsuo, Kawaguchi Tomoya, Chiba Yasutaka, Yoshioka Hiroshige, Watanabe Katsuya, Kijima Takashi, Kogure Yoshihito, Oguri Tetsuya, Yoshimura Naruo, Niwa Takashi, Kasai Takashi, Hayashi Hidetoshi, Ono Akira, Asai Kazuhisa, Tanaka Hiroshi, Yano Seiji, Yamamoto Nobuyuki, Nakanishi Yoichi, Nakagawa Kazuhiko

    Japanese Journal of Clinical Oncology   49 ( 10 )   947 - 955   2019.10( ISSN:0368-2811

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    前化学療法が無効であったEGFR陰性非小細胞肺癌(NSCLC)患者に対するエルロチニブ/ドセタキセル投与の有効性を評価するため、多施設共同単群第I/II相臨床試験を実施した。第I相および第II相では、それぞれエルロチニブの最大耐量(MTD)と推奨用量(RD)、および客観的応答率(ORR)を評価した。21日間の投与サイクル中、1日目にドセタキセル60mg/m2を静脈内投与し、2〜16日目にエルロチニブを食前1時間の空腹時または食後2時間に経口投与した。エルロチニブの増量は、100〜150mgの間で標準的な3+3デザインを採用した。第II相では、1日目のドキタキセルの静脈内投与後、第I相で決定した投与量のエルロチニブを2〜16日目に反復経口投与した。第I相では、MTDに達することなく計画した用量漸増が完了したことから、エルロチニブのRDは150mgとした。第II相では、ORRおよび疾病制御率はそれぞれ17.1%(95%CI:7.2-32.1%)および53.7%(95%CI:37.4-69.3%)であった。無増悪生存期間および全生存期間の中央値は、それぞれ3.5ヵ月(95%CI:3.1-4.5ヵ月)および11.3ヵ月(95%CI:8.6-16.6ヵ月)であった。発現頻度が高かった非血液学的有害事象は、発熱性好中球減少症(グレード3-4:19.6%)であった。治験薬投与に関連のある死亡として、間質性肺疾患および胸膜感染による死亡が2件報告された。以上より、ドセタキセルとエルロチニブの断続的投与との併用は、第I相では臨床的実現性が示されたが、第IIでORRの有意な改善はみられなかった。

  • EGFR遺伝子変異がみられる非小細胞肺癌の患者において腫瘍微小環境が上皮成長因子受容体チロシンキナーゼ阻害薬の有効性に及ぼす影響(Impact of tumor microenvironment on the efficacy of epidermal growth factor receptor-tyrosine kinase inhibitors in patients with EGFR-mutant non-small cell lung cancer)

    Matsumoto Yoshiya, Sawa Kenji, Fukui Mitsuru, Oyanagi Jun, Izumi Motohiro, Ogawa Koichi, Suzumura Tomohiro, Watanabe Tetsuya, Kaneda Hiroyasu, Mitsuoka Shigeki, Asai Kazuhisa, Kimura Tatsuo, Yamamoto Nobuyuki, Koh Yasuhiro, Kawaguchi Tomoya

    Cancer Science   110 ( 10 )   3244 - 3254   2019.10( ISSN:1347-9032

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    非小細胞肺癌への1次治療として上皮成長因子受容体(EGFR)チロシンキナーゼ阻害薬(EGFR-TKI)治療を行った時の有効性に関して腫瘍微小環境が及ぼす影響を検討した。EGFR遺伝子に変異が認められる進行非小細胞肺癌患者の診療録を精査した。2013年8月〜2017年12月に当院で診療した上記の患者52名(女性35名)を最終的な解析対象とした。治療前に得た検体に対し免疫組織化学解析を行い、腫瘍細胞におけるprogrammed cell death-1 ligand-1(PD-L1)陽性細胞の割合のスコア、およびCD8陽性腫瘍浸潤リンパ球(TIL)の浸潤の程度を示すスコアを評価して、それらの高低を組み合わせた4群に症例を分類した。両スコアが共に高かった群ではprogrammed cell death-1 ligand-2(PD-L2)発現の陽性率が57.1%と4群中で最も高く、奏効率は14.3%と最も低いことがいずれも有意に示された。無増悪生存期間中央値は両スコアが共に高い群で2.4ヵ月と最も短く、PD-L1スコアが低くCD8陽性TILスコアが高い群で17.5ヵ月と最も長いことも有意に示された。PD-L1発現とCD8陽性TILで評価した治療前の腫瘍微小環境によってEGFR-TKIの有効性が異なることが明らかになった。

  • Impact of tumor microenvironment on the efficacy of epidermal growth factor receptor-tyrosine kinase inhibitors in patients with EGFR-mutant non-small cell lung cancer.

    Matsumoto Y, Sawa K, Fukui M, Oyanagi J, Izumi M, Ogawa K, Suzumura T, Watanabe T, Kaneda H, Mitsuoka S, Asai K, Kimura T, Yamamoto N, Koh Y, Kawaguchi T

    Cancer science   110 ( 10 )   3244 - 3254   2019.10( ISSN:1347-9032

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  • Irisin secreted from muscle by exercise ameliorates emphysema of cigarette smoke-induced COPD in mice Reviewed

    Kubo Hiroaki, Asai Kazuhisa, Miyamoto Atsushi, Kadotani Hideaki, Maruyama Naomi, Kojima Kazuya, Sugitani Arata, Kyomoto Yohkoh, Okamoto Atsuko, Yamada Kazuhiro, Watanabe Tetsuya, Kawaguchi Tomoya, Hirata Kazuto

    EUROPEAN RESPIRATORY JOURNAL   54   2019.09( ISSN:0903-1936

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    DOI: 10.1183/13993003.congress-2019.PA4048

  • A Case of Sarcoidosis with Reversed Halo Sign Diagnosed by EBUS-TBNA

    Inada Yuya, Itoh Tomoyoshi, Mizutani Ryo, Kawamoto Kengo, Iwasaki Kohei, Tamura Kanako, Yoshida Shinya, Kawaguchi Tomoya, Hirata Kazuto

    The Journal of the Japan Society for Respiratory Endoscopy   41 ( 5 )   485 - 490   2019.09( ISSN:02872137 ( eISSN:21860149

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    <p><b><i>Background.</i></b> Sarcoidosis exhibiting the reversed halo sign (RHS) is rarely encountered. We herein report a case of sarcoidosis exhibiting the RHS that was diagnosed using endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA). <b><i>Case.</i></b> A 77-year-old male patient was monitored following a complete atrioventricular block (complete AVB) performed by another physician and was admitted to the internal cardiology department with a secondary complaint of heart failure. Abnormal shadows were noted on chest X-ray photographs and invasive shadows exhibiting RHS were observed on chest computed tomography (CT), which prompted his admission to the department. Cardiac sarcoidosis was suspected, as the patient had a history of a complete AVB and there was a decline in his advanced cardiac function. <sup>18</sup>F-fluorodeoxyglucose-positron emission tomography (FDG-PET) and a myocardial biopsy were performed but resulted in no definitive diagnosis. Multiple diffuse shadows, nodular shadows and RHS with mural nodules, and enlargement of the mediastinal and bilateral hilar lymph nodes were observed on chest CT. While a transbronchial lung biopsy (TBLB) did not result in a diagnosis, EBUS-TBNA of the enlarged mediastinal lymph nodes revealed non-caseating epithelioid cell granuloma, leading to the diagnosis of biopsy-proven sarcoidosis. Although the RHS resolved naturally without treatment, the multiple diffuse shadows and nodular shadows and enlargement of the mediastinal and bilateral hilar lymph nodes persisted. The multiple shadows and nodular shadows disappeared following the initiation of steroid treatment, and simultaneously, the enlargement of the mediastinal and bilateral hilar lymph nodes was also ameliorated. <b><i>Conclusion.</i></b> In cases with enlargement of mediastinal lymph nodes and RHS with mural nodules, EBUS-TBNA should be actively used as a diagnostic method, in consideration of the possible presence of sarcoidosis.</p>

    DOI: 10.18907/jjsre.41.5_485

    CiNii Article

  • Isoflavone Aglycones Attenuate Cigarette Smoke-Induced Emphysema via Suppression of Neutrophilic Inflammation in a COPD Murine Model Reviewed

    Kojima Kazuya, Asai Kazuhisa, Kubo Hiroaki, Sugitani Arata, Kyomoto Yohkoh, Okamoto Atsuko, Yamada Kazuhiro, Ijiri Naoki, Watanabe Tetsuya, Hirata Kazuto, Kawaguchi Tomoya

    NUTRIENTS   11 ( 9 )   2019.09

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    DOI: 10.3390/nu11092023

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  • EBUS-TBNAで診断したreversed halo signを呈するサルコイドーシスの1例 Reviewed

    稲田 祐也, 伊東 友好, 水谷 亮, 河本 健吾, 岩崎 剛平, 田村 佳菜子, 吉田 真也, 川口 知哉, 平田 一人

    (NPO)日本呼吸器内視鏡学会 気管支学   41 ( 5 )   485 - 490   2019.09( ISSN:0287-2137

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    背景.Reversed halo sign(RHS)を呈するサルコイドーシスは稀である。超音波気管支鏡ガイド下針生検(endobronchial ultrasound-guided transbronchial needle aspiration:EBUS-TBNA)で診断したRHSを呈するサルコイドーシスの症例を経験したので、報告する。症例.77歳、男性。近医で完全房室ブロックの経過観察中であったが心不全を合併し、当院循環器内科に入院した。その際の胸部単純X線写真で胸部異常陰影を指摘され、胸部単純CTでRHSを呈する浸潤影を認めたため、当科へ紹介となった。完全房室ブロックの既往および高度心機能低下を認めて心臓サルコイドーシスを疑い、フルオロデオキシグルコース-陽電子放射断層撮影(18F-fluorodeoxyglucose-positron emission tomography:FDG-PET)と心筋生検が行われたが、確定診断には至らなかった。胸部単純CTでびまん性多発粒状影と結節影、壁在結節を伴うRHS、縦隔と両側肺門リンパ節腫大を認め、経気管支肺生検(transbronchial lung biopsy:TBLB)を行ったが診断に至らなかった。縦隔リンパ節腫大に対してEBUS-TBNAを行ったところ、非乾酪性類上皮細胞肉芽腫を認め、サルコイドーシスの組織診断群と診断した。無治療でRHSのみ自然軽快したが、多発粒状陰影と結節影、縦隔と両側肺門リンパ節腫大は変化なく残存した。ステロイド開始後に多発粒状影と結節影は縮小、消失すると同時に縦隔と両側肺門リンパ節腫大も縮小を認めた。結論.壁在結節を伴うRHSに縦隔リンパ節腫大を認めた際には、サルコイドーシスを念頭に入れてEBUS-TBNAを積極的に併用すべきと考える。(著者抄録)

  • Handgrip strength measurement in patients with chronic obstructive pulmonary disease: Possible predictor of exercise capacity Reviewed

    Kyomoto Yohkoh, Asai Kazuhisa, Yamada Kazuhiro, Okamoto Atsuko, Watanabe Tetsuya, Hirata Kazuto, Kawaguchi Tomoya

    RESPIRATORY INVESTIGATION   57 ( 5 )   499 - 505   2019.09( ISSN:2212-5345

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    DOI: 10.1016/j.resinv.2019.03.014

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  • Handgrip strength measurement in patients with chronic obstructive pulmonary disease: Possible predictor of exercise capacity(和訳中) Reviewed

    Kyomoto Yohkoh, Asai Kazuhisa, Yamada Kazuhiro, Okamoto Atsuko, Watanabe Tetsuya, Hirata Kazuto, Kawaguchi Tomoya

    エルゼビア・ジャパン(株) Respiratory Investigation   57 ( 5 )   499 - 505   2019.09( ISSN:2212-5345

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  • EBUS-TBNAで診断したreversed halo signを呈するサルコイドーシスの1例

    稲田 祐也, 伊東 友好, 水谷 亮, 河本 健吾, 岩崎 剛平, 田村 佳菜子, 吉田 真也, 川口 知哉, 平田 一人

    気管支学   41 ( 5 )   485 - 490   2019.09( ISSN:0287-2137

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    背景.Reversed halo sign(RHS)を呈するサルコイドーシスは稀である。超音波気管支鏡ガイド下針生検(endobronchial ultrasound-guided transbronchial needle aspiration:EBUS-TBNA)で診断したRHSを呈するサルコイドーシスの症例を経験したので、報告する。症例.77歳、男性。近医で完全房室ブロックの経過観察中であったが心不全を合併し、当院循環器内科に入院した。その際の胸部単純X線写真で胸部異常陰影を指摘され、胸部単純CTでRHSを呈する浸潤影を認めたため、当科へ紹介となった。完全房室ブロックの既往および高度心機能低下を認めて心臓サルコイドーシスを疑い、フルオロデオキシグルコース-陽電子放射断層撮影(18F-fluorodeoxyglucose-positron emission tomography:FDG-PET)と心筋生検が行われたが、確定診断には至らなかった。胸部単純CTでびまん性多発粒状影と結節影、壁在結節を伴うRHS、縦隔と両側肺門リンパ節腫大を認め、経気管支肺生検(transbronchial lung biopsy:TBLB)を行ったが診断に至らなかった。縦隔リンパ節腫大に対してEBUS-TBNAを行ったところ、非乾酪性類上皮細胞肉芽腫を認め、サルコイドーシスの組織診断群と診断した。無治療でRHSのみ自然軽快したが、多発粒状陰影と結節影、縦隔と両側肺門リンパ節腫大は変化なく残存した。ステロイド開始後に多発粒状影と結節影は縮小、消失すると同時に縦隔と両側肺門リンパ節腫大も縮小を認めた。結論.壁在結節を伴うRHSに縦隔リンパ節腫大を認めた際には、サルコイドーシスを念頭に入れてEBUS-TBNAを積極的に併用すべきと考える。(著者抄録)

  • Handgrip strength measurement in patients with chronic obstructive pulmonary disease: Possible predictor of exercise capacity.

    Kyomoto Y, Asai K, Yamada K, Okamoto A, Watanabe T, Hirata K, Kawaguchi T

    Respiratory investigation   57 ( 5 )   499 - 505   2019.09( ISSN:2212-5345

  • 慢性閉塞性肺疾患患者の握力測定 運動能力の予測因子となる可能性(Handgrip strength measurement in patients with chronic obstructive pulmonary disease: Possible predictor of exercise capacity)

    Kyomoto Yohkoh, Asai Kazuhisa, Yamada Kazuhiro, Okamoto Atsuko, Watanabe Tetsuya, Hirata Kazuto, Kawaguchi Tomoya

    Respiratory Investigation   57 ( 5 )   499 - 505   2019.09( ISSN:2212-5345

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    慢性閉塞性肺疾患(COPD)患者133例(男性116例、女性17例、平均71.7±9.3歳)を対象に後ろ向き観察研究を行い、6分間歩行試験(6MWT)の距離(6MWD)の予測因子を調べた。対象患者の6MWT、COPD評価試験(CAT)、肺活量測定、呼吸筋力評価、体組成評価、握力(HGS)測定を行った。6MWDと評価したパラメーターとの関連を調べた。その結果、単回帰分析により、6MWDは年齢、CATスコア、いくつかの肺活量測定(例えば、努力性肺活量[%FVC]、1秒率[%FEV1]、肺拡散能力[%DLCO])、呼吸筋力パラメーター(例えば、最大吸気圧および呼気圧の割合)、骨格筋量指標、HGSと有意に相関することが示唆された。重回帰分析により、年齢、CATスコア、%DLCO、HGSは6MWDの独立した予測因子であることが示唆された。%DLCOおよびHGSは、6MWDの予測因子として強く相関していた(p<0.001)。以上から、日本人COPD患者において、HGSは、肺活量測定または呼吸筋力パラメーターと比較して、6MWDと有意に相関し、簡単かつ非侵襲的な予測因子となりうることが示唆された。

  • Isoflavone Aglycones Attenuate Cigarette Smoke-Induced Emphysema via Suppression of Neutrophilic Inflammation in a COPD Murine Model.

    Kojima K, Asai K, Kubo H, Sugitani A, Kyomoto Y, Okamoto A, Yamada K, Ijiri N, Watanabe T, Hirata K, Kawaguchi T

    Nutrients   11 ( 9 )   2019.08

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  • Association between low-frequency pretreatment EGFR T790M mutation and tumor immune microenvironment in patients with EGFR-mutated non-small cell lung cancer Reviewed

    Matsumoto Yoshiya, Sawa Kenji, Fukui Mitsuru, Oyanagi Jun, Izumi Motohiro, Ogawa Koichi, Suzumura Tomohiro, Watanabe Tetsuya, Kaneda Hiroyasu, Mitsuoka Shigeki, Asai Kazuhisa, Kimura Tatsuo, Yamamoto Nobuyuki, Kawaguchi Tomoya, Koh Yasuhiro

    CANCER RESEARCH   79 ( 13 )   2019.07( ISSN:0008-5472

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    DOI: 10.1158/1538-7445.AM2019-4906

  • Phase I/II study of intermitted erlotinib in combination with docetaxel in patients with recurrent non-small cell lung cancer (WJOG4708L). Reviewed

    Kimura T, Kawaguchi T, Chiba Y, Yoshioka H, Watanabe K, Kijima T, Kogure Y, Oguri T, Yoshimura N, Niwa T, Kasai T, Hayashi H, Ono A, Asai K, Tanaka H, Yano S, Yamamoto N, Nakanishi Y, Nakagawa K

    Japanese journal of clinical oncology   2019.06( ISSN:0368-2811

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    DOI: 10.1093/jjco/hyz088

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  • Serum Myostatin Level in COPD Patients with and without Sarcopenia: Application for Biomarker of Sarcopenia Diagnosis(和訳中) Reviewed

    Yoshida Shinya, Asai Kazuhisa, Ijiri Naoki, Kyomoto Yohkoh, Kawamoto Tamaki, Okamoto Atsuko, Yamada Kazuhiro, Watanabe Tetsuya, Tochino Yoshihiro, Kawaguchi Tomoya

    大阪市医学会 Osaka City Medical Journal   65 ( 1 )   1 - 8   2019.06( ISSN:0030-6096

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  • Decreased Level of Phosphatase and Tensin Homolog Deleted from Chromosome 10(PTEN), a Negative Regulator of Phosphoinositide 3-kinase(PI3K)/Serine-threonine Protein Kinase(Akt) Pathway, is Related to Chronic Obstructive Pulmonary Disease(和訳中) Reviewed

    Kawamoto Tamaki, Asai Kazuhisa, Yamada Kazuhiro, Yoshida Shinya, Okamoto Atsuko, Sato Kanako, Ijiri Naoki, Watanabe Tetsuya, Kawaguchi Tomoya

    大阪市医学会 Osaka City Medical Journal   65 ( 1 )   9 - 17   2019.06( ISSN:0030-6096

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  • サルコペニアを併発している/または併発していないCOPD患者における血清ミオスタチン サルコペニア診断のバイオマーカーとしての応用(Serum Myostatin Level in COPD Patients with and without Sarcopenia: Application for Biomarker of Sarcopenia Diagnosis)

    Yoshida Shinya, Asai Kazuhisa, Ijiri Naoki, Kyomoto Yohkoh, Kawamoto Tamaki, Okamoto Atsuko, Yamada Kazuhiro, Watanabe Tetsuya, Tochino Yoshihiro, Kawaguchi Tomoya

    Osaka City Medical Journal   65 ( 1 )   1 - 8   2019.06( ISSN:0030-6096

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    マイオカインの一つであるイリシンとミオスタチンの値が慢性閉塞性肺疾患(COPD)患者のサルコペニアと関連すると考え、検討した。COPD患者39名(全例男、平均74歳)を試験に登録し、非喫煙者30名(全例男、平均74歳)を対照群とした。全被験者の肺機能検査を行い、COPD患者については筋肉量を測定し、サルコペニアか否か診断した。COPD患者をサルコペニア群(9名)と非サルコペニア群(30名)に分けた。その結果、血清ミオスタチン値はサルコペニア非併発群よりも併発群で有意に低かった。イリシン値には、COPD患者のサルコペニア併発の有無による有意差はなかった。血清ミオスタチン値は筋肉量と相関し、COPD患者におけるバイオマーカーになり得ると考えられた。

  • ホスホイノシチド3-キナーゼ(PI3K)/セリン-スレオニンプロテインキナーゼ(Akt)経路の負の調節因子であるPhosphatase and Tensin Homolog Deleted from Chromosome 10(PTEN)の低下は慢性閉塞性肺疾患と関連する(Decreased Level of Phosphatase and Tensin Homolog Deleted from Chromosome 10(PTEN), a Negative Regulator of Phosphoinositide 3-kinase(PI3K)/Serine-threonine Protein Kinase(Akt) Pathway, is Related to Chronic Obstructive Pulmonary Disease)

    Kawamoto Tamaki, Asai Kazuhisa, Yamada Kazuhiro, Yoshida Shinya, Okamoto Atsuko, Sato Kanako, Ijiri Naoki, Watanabe Tetsuya, Kawaguchi Tomoya

    Osaka City Medical Journal   65 ( 1 )   9 - 17   2019.06( ISSN:0030-6096

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    PTENはPI3K/Akt経路の負の調節因子で、慢性閉塞性肺疾患(COPD)と最も強く関連しているが、その発病に果たす役割は不明なので検討した。COPD患者(49名:男42名、女7名、平均69.4歳)、健康な大量喫煙者(31名:男26名、女5名、平均67.6歳)、健康な非喫煙者(22名:男6名、女16名、平均67.1歳)から気管支上皮細胞を採取して、PTEN発現を比較した。その結果、COPD群では気管支上皮細胞のPTEN発現が有意に低下し、喫煙指数と負の相関を示した。PTEN mRNA発現は、%FEV、FEV1/FVCと一酸化炭素の肺の%拡散能のような閉塞障害のパラメータと有意に相関した。各群間でPI3Kδ mRNAに有意差はなかった。以上より、COPD患者のPTEN発現は健康な非喫煙者よりも有意に低く、PTEN発現の低下がCOPDの発症、特に閉塞性障害と関連すると考えられた。

  • Can smoking duration alone replace pack-years to predict the risk of smoking-related oncogenic mutations in non-small cell lung cancer (NSCLC)? Reviewed

    Ogawa Koichi, Kawaguchi Tomoya, Koh Yasuhiro, Isa Shun-Ichi, Kubo Akihito, Ando Masahiko, Saka Hideo, Yoshimoto Naoki, Matsumura Akihide, Kaneda Hiroyasu, Tamiya Akihiro, Taniguchi Yoshihiko, Sawa Kenji, Matsumoto Yoshiya, Izumi Motohiro

    JOURNAL OF CLINICAL ONCOLOGY   37 ( 15 )   2019.05( ISSN:0732-183X

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  • Annual lung cancer screening by chest x-ray results in higher profits for the exclusion of lung cancer. Reviewed

    Kimura Tatsuo, Fukumoto Shinya, Morikawa Hiroyasu, Nakano Akemi, Otani Koji, Tauchi Yukie, Uemura Risa, Suzumura Tomohiro, Ogawa Koichi, Kawaguchi Tomoya, Kawada Norifumi

    JOURNAL OF CLINICAL ONCOLOGY   37 ( 15 )   2019.05( ISSN:0732-183X

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  • Efficacy and safety of ultrasound (US) guided percutaneous needle biopsy for peripheral lung or pleural lesion: comparison with computed tomography (CT) guided needle biopsy Reviewed

    Yamamoto Norio, Watanabe Tetsuya, Yamada Kazuhiro, Nakai Toshiyuki, Suzumura Tomohiro, Sakagami Kazuki, Yoshimoto Naoki, Sato Kanako, Tanaka Hidenori, Mitsuoka Shigeki, Asai Kazuhisa, Kimura Tatsuo, Kanazawa Hiroshi, Hirata Kazuto, Kawaguchi Tomoya

    JOURNAL OF THORACIC DISEASE   11 ( 3 )   936 - 943   2019.03( ISSN:2072-1439

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    DOI: 10.21037/jtd.2019.01.88

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  • Efficacy and safety of ultrasound (US) guided percutaneous needle biopsy for peripheral lung or pleural lesion: comparison with computed tomography (CT) guided needle biopsy.

    Yamamoto N, Watanabe T, Yamada K, Nakai T, Suzumura T, Sakagami K, Yoshimoto N, Sato K, Tanaka H, Mitsuoka S, Asai K, Kimura T, Kanazawa H, Hirata K, Kawaguchi T

    Journal of thoracic disease   11 ( 3 )   936 - 943   2019.03( ISSN:2072-1439

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  • 気管支鏡検査と個別化医療

    川口 知哉

    気管支学   41 ( 1 )   1 - 20   2019.01( ISSN:02872137 ( eISSN:21860149

  • Possible role of airway microvascular permeability on airway obstruction in patients with chronic obstructive pulmonary disease Reviewed

    Kyomoto Yohkoh, Kanazawa Hiroshi, Tochino Yoshihiro, Watanabe Tetsuya, Asai Kaziuhisa, Kawaguchi Tomoya

    RESPIRATORY MEDICINE   146   137 - 141   2019.01( ISSN:0954-6111

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.rmed.2018.12.007

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  • Possible role of airway microvascular permeability on airway obstruction in patients with chronic obstructive pulmonary disease.

    Kyomoto Y, Kanazawa H, Tochino Y, Watanabe T, Asai K, Kawaguchi T

    Respiratory medicine   146   137 - 141   2019.01( ISSN:0954-6111

  • Exercise Ameliorates Emphysema Of Cigarette Smoke-Induced COPD In Mice Through The Exercise-Irisin-Nrf2 Axis Reviewed

    Kubo Hiroaki, Asai Kazuhisa, Kojima Kazuya, Sugitani Arata, Kyomoto Yohkoh, Okamoto Atsuko, Yamada Kazuhiro, Ijiri Naoki, Watanabe Tetsuya, Hirata Kazuto, Kawaguchi Tomoya

    INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE   14   2507 - 2516   2019( ISSN:1178-2005

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.2147/COPD.S226623

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  • 気管支鏡検査と個別化医療 Reviewed

    川口 知哉

    特定非営利活動法人 日本呼吸器内視鏡学会 気管支学   41 ( 1 )   1 - 20   2019( ISSN:0287-2137

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    DOI: 10.18907/jjsre.41.1_1

    CiNii Article

  • A Case of Sarcoidosis with Reversed Halo Sign Diagnosed by EBUS-TBNA Reviewed

    Inada Yuya, Itoh Tomoyoshi, Mizutani Ryo, Kawamoto Kengo, Iwasaki Kohei, Tamura Kanako, Yoshida Shinya, Kawaguchi Tomoya, Hirata Kazuto

    The Japan Society for Respiratory Endoscopy, The Journal of the Japan Society for Respiratory Endoscopy   41 ( 5 )   485 - 490   2019( ISSN:0287-2137

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    <p><b><i>Background.</i></b> Sarcoidosis exhibiting the reversed halo sign (RHS) is rarely encountered. We herein report a case of sarcoidosis exhibiting the RHS that was diagnosed using endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA). <b><i>Case.</i></b> A 77-year-old male patient was monitored following a complete atrioventricular block (complete AVB) performed by another physician and was admitted to the internal cardiology department with a secondary complaint of heart failure. Abnormal shadows were noted on chest X-ray photographs and invasive shadows exhibiting RHS were observed on chest computed tomography (CT), which prompted his admission to the department. Cardiac sarcoidosis was suspected, as the patient had a history of a complete AVB and there was a decline in his advanced cardiac function. <sup>18</sup>F-fluorodeoxyglucose-positron emission tomography (FDG-PET) and a myocardial biopsy were performed but resulted in no definitive diagnosis. Multiple diffuse shadows, nodular shadows and RHS with mural nodules, and enlargement of the mediastinal and bilateral hilar lymph nodes were observed on chest CT. While a transbronchial lung biopsy (TBLB) did not result in a diagnosis, EBUS-TBNA of the enlarged mediastinal lymph nodes revealed non-caseating epithelioid cell granuloma, leading to the diagnosis of biopsy-proven sarcoidosis. Although the RHS resolved naturally without treatment, the multiple diffuse shadows and nodular shadows and enlargement of the mediastinal and bilateral hilar lymph nodes persisted. The multiple shadows and nodular shadows disappeared following the initiation of steroid treatment, and simultaneously, the enlargement of the mediastinal and bilateral hilar lymph nodes was also ameliorated. <b><i>Conclusion.</i></b> In cases with enlargement of mediastinal lymph nodes and RHS with mural nodules, EBUS-TBNA should be actively used as a diagnostic method, in consideration of the possible presence of sarcoidosis.</p>

    DOI: 10.18907/jjsre.41.5_485

    CiNii Article

  • Nrf2 Polymorphisms Contributes to Emphysema in Healthy Smokers Reviewed

    Sugitani A., Asai K., Miyamoto A., Kojima K., Kubo H., Kyoumoto Y., Kawamoto T., Yoshida S., Okamoto A., Satou K., Yamada K., Ijiri N., Watanabe T., Tochino Y., Kanazawa H., Kimura T., Fukumoto S., Hirata K., Kawaguchi T.

    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE   199   2019( ISSN:1073-449X

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  • Exercise Ameliorates Emphysema Of Cigarette Smoke-Induced COPD In Mice Through The Exercise-Irisin-Nrf2 Axis.

    Kubo H, Asai K, Kojima K, Sugitani A, Kyomoto Y, Okamoto A, Yamada K, Ijiri N, Watanabe T, Hirata K, Kawaguchi T

    International journal of chronic obstructive pulmonary disease   14   2507 - 2516   2019( ISSN:1176-9106

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  • DECREASED LEVELS OF PTEN, A NEGATIVE REGULATOR OF PHOSPHOINOSITIDE 3-KINASE (PI3K)/AKT PATHWAY, ARE CORRELATED WITH OBSTRUCTIVE IMPAIRMENT OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE Reviewed

    Kawamoto Tamaki, Yamada Kazuhiro, Asai Kazuhisa, Sato Kanako, Nakai Toshiyuki, Yamamoto Norio, Ijiri Naoki, Watanabe Tetsuya, Hirata Kazuto, Kawaguchi Tomoya

    RESPIROLOGY   23   11 - 12   2018.11( ISSN:1323-7799

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  • Impact of de Novo T790M on Outcome for Resected NSCLC from EGFR Mutant Cohort of Japan Molecular Epidemiology (JME) Study Reviewed

    Matsumoto Y., Kawaguchi T., Sawa K., Isa S., Ando M., Tamiya A., Kubo A., Saka H., Matsumura A., Koh Y.

    JOURNAL OF THORACIC ONCOLOGY   13 ( 10 )   S833 - S833   2018.10( ISSN:1556-0864

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  • Dose Escalation Study of Concurrent Chemoradiotherapy With the Use of Involved-field Conformal Radiotherapy and Accelerated Hyperfractionation in Combination With Cisplatin and Vinorelbine Chemotherapy for Stage III Non-small Cell Lung Cancer: The Final Report.

    Yoshimura N, Tada T, Matsumoto Y, Sawa K, Yoshimoto N, Suzumura T, Tanaka H, Mitsuoka S, Kimura T, Tamiya T, Hirashima T, Kawaguchi T, Kudoh S, Hosono M, Hirata K

    American journal of clinical oncology   41 ( 10 )   967 - 971   2018.10( ISSN:0277-3732

  • Evaluation of the severity of small airways obstruction and alveolar destruction in chronic obstructive pulmonary disease Reviewed

    Kawamoto Tamaki, Kanazawa Hiroshi, Tochino Yoshihiro, Kawaguchi Tomoya

    RESPIRATORY MEDICINE   141   159 - 164   2018.08( ISSN:0954-6111

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    DOI: 10.1016/j.rmed.2018.07.002

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  • Phase1 study of cisplatin plus pemetrexed with erlotinib and bevacizumab for chemotherapy-naïve advanced non-squamous non-small cell lung cancer with EGFR mutations.

    Tamiya M, Tamiya A, Shiroyama T, Takeoka S, Naito Y, Omachi N, Kimura Y, Morishita N, Suzuki H, Okamoto N, Okishio K, Kawaguchi T, Atagi S, Hirashima T

    Investigational new drugs   36 ( 4 )   608 - 614   2018.08( ISSN:0167-6997

  • Evaluation of the severity of small airways obstruction and alveolar destruction in chronic obstructive pulmonary disease.

    Kawamoto T, Kanazawa H, Tochino Y, Kawaguchi T

    Respiratory medicine   141   159 - 164   2018.08( ISSN:0954-6111

  • Predictive impact of low-frequency pretreatment T790M mutation in patients with EGFR-mutated non-small cell lung cancer treated with EGFR tyrosine kinase inhibitors Reviewed

    Matsumoto Yoshiya, Sawa Kenji, Oyanagi Jun, Fukui Mitsuru, Yoshimoto Naoki, Suzumura Tomohiro, Mitsuoka Shigeki, Asai Kazuhisa, Kimura Tatsuo, Yamamoto Nobuyuki, Kawaguchi Tomoya, Hirata Kazuto, Koh Yasuhiro

    CANCER RESEARCH   78 ( 13 )   2018.07( ISSN:0008-5472

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    DOI: 10.1158/1538-7445.AM2018-2613

  • Co-mutations in surgically resected and EGFR mutated lung adenocarcinoma: A subset analysis of the large prospective cohort study. Reviewed

    Sawa Kenji, Kawaguchi Tomoya, Koh Yasuhiro, Kubo Akihito, Tamiya Akihiro, Yoshimoto Naoki, Isa Shun-ichi, Saka Hideo, Matsumura Akihide

    JOURNAL OF CLINICAL ONCOLOGY   36 ( 15 )   2018.05( ISSN:0732-183X

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  • Impact of somatic mutations on recurrence free survival (RFS) and overall survival (OS) for resected nonsmall cell lung cancer (NSCLC): results from the Japan Molecular Epidemiology for lung cancer study (JME). Reviewed

    Tamiya Akihiro, Koh Yasuhiro, Kubo Akihito, Ando Masahiko, Isa Shun-ichi, Saka Hideo, Yoshimoto Naoki, Serizawa Masakuni, Takeo Sadanori, Adachi Hirofumi, Tagawa Tsutomu, Kawashima Osamu, Yamashita Motohiro, Kataoka Kazuhiko, Ichinose Yukito, Takeuchi Yukiyasu, Watanabe Katsuya, Matsumura Akihide, Kawaguchi Tomoya

    JOURNAL OF CLINICAL ONCOLOGY   36 ( 15 )   2018.05( ISSN:0732-183X

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  • Chemotherapy versus erlotinib as second-line treatment in patients with advanced non-small cell lung cancer and wild-type epidermal growth factor receptor: an individual patient data (IPD) analysis. Reviewed

    Garassino MC, Kawaguchi T, Gregorc V, Rulli E, Ando M, Marsoni S, Isa SI, Novello S, Farina G, Barni S, Torri V, Cinquini M

    ESMO open   3 ( 6 )   e000327   2018

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    DOI: 10.1136/esmoopen-2018-000327

    PubMed

  • Chemotherapy versus erlotinib as second-line treatment in patients with advanced non-small cell lung cancer and wild-type epidermal growth factor receptor: an individual patient data (IPD) analysis.

    Garassino MC, Kawaguchi T, Gregorc V, Rulli E, Ando M, Marsoni S, Isa SI, Novello S, Farina G, Barni S, Torri V, Cinquini M

    ESMO open   3 ( 6 )   e000327   2018

  • Phase1 study of cisplatin plus pemetrexed with erlotinib and bevacizumab for chemotherapy-naïve advanced non-squamous non-small cell lung cancer with EGFR mutations. Reviewed

    Tamiya M, Tamiya A, Shiroyama T, Takeoka S, Naito Y, Omachi N, Kimura Y, Morishita N, Suzuki H, Okamoto N, Okishio K, Kawaguchi T, Atagi S, Hirashima T

    Investigational new drugs   2017.11( ISSN:0167-6997

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    DOI: 10.1007/s10637-017-0527-z

    PubMed

  • Phase I/II Study of Intermitted Erlotinib in Combination with Docetaxel in Patients with Recurrent NSCLC with Wild-Type EGFR: WJOG 4708L Reviewed

    Kimura T., Kawaguchi T., Kudoh S., Chiba Y., Yoshioka H., Watanabe K., Kijima T., Kogure Y., Oguri T., Yoshimura N., Niwa T., Kasai T., Hayashi H., Ono A., Tanaka H., Yano S., Nakamura S., Yamamoto N., Nakanishi Y., Nakagawa K.

    JOURNAL OF THORACIC ONCOLOGY   12 ( 11 )   S2129 - S2129   2017.11( ISSN:1556-0864

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  • Higher Body Mass Index Prolongs Survival Time in Non-Small Cell Lung Cancer with Good Performance Status Reviewed

    Suzumura T., Kawaguchi T., Mitsuoka S., Kimura T., Yoshimura N., Yoshimoto N., Sawa K., Matsumoto Y., Hirata K.

    JOURNAL OF THORACIC ONCOLOGY   12 ( 11 )   S1990 - S1990   2017.11( ISSN:1556-0864

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  • Molecular Epidemiology Reviewed

    Kawaguchi T., Sawa K., Yoshimoto N., Hirata K., Mack P.

    JOURNAL OF THORACIC ONCOLOGY   12 ( 11 )   S1669 - S1669   2017.11( ISSN:1556-0864

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  • Dose Escalation Study of Concurrent Chemoradiotherapy With the Use of Involved-field Conformal Radiotherapy and Accelerated Hyperfractionation in Combination With Cisplatin and Vinorelbine Chemotherapy for Stage III Non-small Cell Lung Cancer: The Final Report. Reviewed

    Yoshimura N, Tada T, Matsumoto Y, Sawa K, Yoshimoto N, Suzumura T, Tanaka H, Mitsuoka S, Kimura T, Tamiya T, Hirashima T, Kawaguchi T, Kudoh S, Hosono M, Hirata K

    American journal of clinical oncology   2017.10( ISSN:0277-3732

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1097/COC.0000000000000412

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  • PIK3CA mutation as a distinctive genetic feature of non-small cell lung cancer with chronic obstructive pulmonary disease: A comprehensive mutational analysis from a multi-institutional cohort Reviewed

    Sawa Kenji, Koh Yasuhiro, Kawaguchi Tomoya, Kambayashi Satoshi, Asai Kazuhisa, Mitsuoka Shigeki, Kimura Tatsuo, Yoshimura Naruo, Yoshimoto Naoki, Kubo Akihito, Saka Hideo, Matsumura Akihide, Wanibuchi Hideki, Yamamoto Nobuyuki, Nishiyama Noritoshi, Hirata Kazuto

    LUNG CANCER   112   96 - 101   2017.10( ISSN:0169-5002

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    DOI: 10.1016/j.lungcan.2017.07.039

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  • PIK3CA mutation as a distinctive genetic feature of non-small cell lung cancer with chronic obstructive pulmonary disease: A comprehensive mutational analysis from a multi-institutional cohort.

    Sawa K, Koh Y, Kawaguchi T, Kambayashi S, Asai K, Mitsuoka S, Kimura T, Yoshimura N, Yoshimoto N, Kubo A, Saka H, Matsumura A, Wanibuchi H, Yamamoto N, Nishiyama N, Hirata K

    Lung cancer (Amsterdam, Netherlands)   112   96 - 101   2017.10( ISSN:0169-5002

  • Interstitial Lung Disease Induced by Osimertinib for Epidermal Growth Factor Receptor (EGFR) T790M-positive Non-small Cell Lung Cancer

    Matsumoto Yoshiya, Kawaguchi Tomoya, Yamamoto Norio, Sawa Kenji, Yoshimoto Naoki, Suzumura Tomohiro, Watanabe Tetsuya, Mitsuoka Shigeki, Asai Kazuhisa, Kimura Tatsuo, Yoshimura Naruo, Kuwae Yuko, Hirata Kazuto

    Internal Medicine   56 ( 17 )   2325 - 2328   2017.09( ISSN:0918-2918 ( eISSN:13497235

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    <p>A 75-year-old man with stage IV lung adenocarcinoma was treated with osimertinib due to disease progression despite having been administered erlotinib. Both an epidermal growth factor receptor (EGFR) L858R mutation on exon 21 and a T790M mutation on exon 20 were detected in a specimen from a recurrent primary tumor. Five weeks after osimertinib initiation, he developed general fatigue and dyspnea. Chest computed tomography scan revealed diffuse ground glass opacities and consolidation on both lungs. An analysis of the bronchoalveolar lavage fluid revealed marked lymphocytosis, and a transbronchial lung biopsy specimen showed a thickened interstitium with fibrosis and prominent lymphocytic infiltration. We diagnosed the patient to have interstitial lung disease induced by osimertinib. </p>

    DOI: 10.2169/internalmedicine.8467-16

    PubMed

    CiNii Article

  • 上皮成長因子受容体(EGFR)T790M陽性非小細胞肺癌に対するオシメルチニブによって生じた間質性肺疾患(Interstitial Lung Disease Induced by Osimertinib for Epidermal Growth Factor Receptor(EGFR) T790M-positive Non-small Cell Lung Cancer) Reviewed

    Matsumoto Yoshiya, Kawaguchi Tomoya, Yamamoto Norio, Sawa Kenji, Yoshimoto Naoki, Suzumura Tomohiro, Watanabe Tetsuya, Mitsuoka Shigeki, Asai Kazuhisa, Kimura Tatsuo, Yoshimura Naruo, Kuwae Yuko, Hirata Kazuto

    (一社)日本内科学会 Internal Medicine   56 ( 17 )   2325 - 2328   2017.09( ISSN:0918-2918

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    症例は75歳男性で、喫煙歴はなかったが、脳転移を伴うステージIV肺腺癌と診断された。遺伝子検査でエクソン21のEGFR L858R変異が明らかになったため、ファーストライン治療としてエルロチニブ投与を行ったところ部分寛解が得られた。7ヵ月後のCTで肺原発腫瘍の再増殖が認められ、生検でエクソン21のEGFR L858R変異とエクソン20のT790M変異が明らかになったため、セカンドライン治療としてオシメルチニブ投与を開始した。その5週間後、全身疲労と呼吸困難が出現し、胸部CTで両肺野にび漫性のスリガラス陰影とコンソリデーションが明らかになった。気管支肺胞洗浄液の分析では著明なリンパ球増加が認められ、経気管支肺生検で線維化と著明なリンパ球浸潤を伴う肥厚した間質が明らかになった。これらの所見からオシメルチニブによって生じた間質性肺疾患と診断した。メチルプレドニゾロンパルス療法後にプレドニゾロン投与を行い、入院38日目に退院となった。

  • Association Between Environmental Tobacco Smoke Exposure and the Occurrence of EGFR Mutations and ALK Rearrangements in Never-smokers With NoneSmall-cell Lung Cancer: Analyses From a Prospective Multinational ETS Registry Reviewed

    Soo Ross A., Kubo Akihito, Ando Masahiko, Kawaguchi Tomoya, Ahn Myung-Ju, Ou Sai-Hong Ignatius

    CLINICAL LUNG CANCER   18 ( 5 )   535 - 542   2017.09( ISSN:1525-7304

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    DOI: 10.1016/j.cllc.2017.01.005

    PubMed

  • Association Between Environmental Tobacco Smoke Exposure and the Occurrence of EGFR Mutations and ALK Rearrangements in Never-smokers With Non-Small-cell Lung Cancer: Analyses From a Prospective Multinational ETS Registry.

    Soo RA, Kubo A, Ando M, Kawaguchi T, Ahn MJ, Ou SI

    Clinical lung cancer   18 ( 5 )   535 - 542   2017.09( ISSN:1525-7304

  • 上皮成長因子受容体(EGFR)T790M陽性非小細胞肺癌に対するオシメルチニブによって生じた間質性肺疾患(Interstitial Lung Disease Induced by Osimertinib for Epidermal Growth Factor Receptor(EGFR) T790M-positive Non-small Cell Lung Cancer)

    Matsumoto Yoshiya, Kawaguchi Tomoya, Yamamoto Norio, Sawa Kenji, Yoshimoto Naoki, Suzumura Tomohiro, Watanabe Tetsuya, Mitsuoka Shigeki, Asai Kazuhisa, Kimura Tatsuo, Yoshimura Naruo, Kuwae Yuko, Hirata Kazuto

    Internal Medicine   56 ( 17 )   2325 - 2328   2017.09( ISSN:0918-2918

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    症例は75歳男性で、喫煙歴はなかったが、脳転移を伴うステージIV肺腺癌と診断された。遺伝子検査でエクソン21のEGFR L858R変異が明らかになったため、ファーストライン治療としてエルロチニブ投与を行ったところ部分寛解が得られた。7ヵ月後のCTで肺原発腫瘍の再増殖が認められ、生検でエクソン21のEGFR L858R変異とエクソン20のT790M変異が明らかになったため、セカンドライン治療としてオシメルチニブ投与を開始した。その5週間後、全身疲労と呼吸困難が出現し、胸部CTで両肺野にび漫性のスリガラス陰影とコンソリデーションが明らかになった。気管支肺胞洗浄液の分析では著明なリンパ球増加が認められ、経気管支肺生検で線維化と著明なリンパ球浸潤を伴う肥厚した間質が明らかになった。これらの所見からオシメルチニブによって生じた間質性肺疾患と診断した。メチルプレドニゾロンパルス療法後にプレドニゾロン投与を行い、入院38日目に退院となった。

  • Multiplex Ultrasensitive Genotyping of Patients with Non-Small Cell Lung Cancer for Epidermal Growth Factor Receptor (EGFR) Mutations by Means of Picodroplet Digital PCR Reviewed

    Watanabe Masaru, Kawaguchi Tomoya, Isa Shun-ichi, Andof Masahiko, Tamiya Akihiro, Kubo Akihito, Saka Hideo, Takeo Sadanori, Adachi Hirofumi, Tagawa Tsutomu, Kawashima Osamu, Yamashita Motohiro, Kataoka Kazuhiko, Ichinose Yukito, Takeuchi Yukiyasu, Watanabe Katsuya, Matsumura Akihide, Koh Yasuhiro

    EBIOMEDICINE   21   86 - 93   2017.07( ISSN:2352-3964

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    DOI: 10.1016/j.ebiom.2017.06.003

    PubMed

  • Multiplex Ultrasensitive Genotyping of Patients with Non-Small Cell Lung Cancer for Epidermal Growth Factor Receptor (EGFR) Mutations by Means of Picodroplet Digital PCR.

    Watanabe M, Kawaguchi T, Isa SI, Ando M, Tamiya A, Kubo A, Saka H, Takeo S, Adachi H, Tagawa T, Kawashima O, Yamashita M, Kataoka K, Ichinose Y, Takeuchi Y, Watanabe K, Matsumura A, Koh Y

    EBioMedicine   21   86 - 93   2017.07

  • Phase I/II study of docetaxel combined with resminostat, an oral hydroxamic acid HDAC inhibitor, for advanced non-small cell lung cancer in patients previously treated with platinum-based chemotherapy Reviewed

    Tambo Yuichi, Hosomi Yukio, Sakai Hiroshi, Nogami Naoyuki, Atagi Shinji, Sasaki Yasutsuna, Kato Terufumi, Takahashi Toshiaki, Seto Takashi, Maemondo Makoto, Nokihara Hiroshi, Koyama Ryo, Nakagawa Kazuhiko, Kawaguchi Tomoya, Okamura Yuta, Nakamura Osamu, Nishio Makoto, Tamura Tomohide

    INVESTIGATIONAL NEW DRUGS   35 ( 2 )   217 - 226   2017.04( ISSN:0167-6997

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s10637-017-0435-2

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  • Phase I/II study of docetaxel combined with resminostat, an oral hydroxamic acid HDAC inhibitor, for advanced non-small cell lung cancer in patients previously treated with platinum-based chemotherapy.

    Tambo Y, Hosomi Y, Sakai H, Nogami N, Atagi S, Sasaki Y, Kato T, Takahashi T, Seto T, Maemondo M, Nokihara H, Koyama R, Nakagawa K, Kawaguchi T, Okamura Y, Nakamura O, Nishio M, Tamura T

    Investigational new drugs   35 ( 2 )   217 - 226   2017.04( ISSN:0167-6997

  • Site- and phase-selective x-ray absorption spectroscopy based on phase-retrieval calculation.

    Kawaguchi T, Fukuda K, Matsubara E

    Journal of physics. Condensed matter : an Institute of Physics journal   29 ( 11 )   113002   2017.03( ISSN:0953-8984

  • Duration of Twice-Daily Thoracic Radiotherapy and Time From the Start of Any Treatment to the End of Chest Irradiation as Significant Predictors of Outcomes in Limited-Disease Small-Cell Lung Cancer Reviewed

    Morimoto Masahiro, Okishio Kyoichi, Akira Masanori, Omachi Naoki, Tamiya Akihiro, Asami Kazuhiro, Kawaguchi Tomoya, Atagi Shinji

    CLINICAL LUNG CANCER   18 ( 2 )   E117 - E127   2017.03( ISSN:1525-7304

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.cllc.2016.09.004

    PubMed

  • Duration of Twice-Daily Thoracic Radiotherapy and Time From the Start of Any Treatment to the End of Chest Irradiation as Significant Predictors of Outcomes in Limited-Disease Small-Cell Lung Cancer.

    Morimoto M, Okishio K, Akira M, Omachi N, Tamiya A, Asami K, Kawaguchi T, Atagi S

    Clinical lung cancer   18 ( 2 )   e117 - e127   2017.03( ISSN:1525-7304

  • Dose Escalation Study of CDDP plus PEM with Erlotinib and Bev Followed by PEM with Erlotinib and Bev for Non-SQ NSCLC Harboring EGFR Mutations Reviewed

    Tamiya Motohiro, Tamiya Akihiro, Shiroyama Takayuki, Takeoka Sawa, Naito Yujiro, Omachi Naoki, Kimura Yohei, Morishita Naoko, Suzuki Hidekazu, Okamoto Norio, Okishio Kyoichi, Kawaguchi Tomoya, Atagi Shinji, Hirashima Tomonori

    JOURNAL OF THORACIC ONCOLOGY   12 ( 1 )   S1244 - S1244   2017.01( ISSN:1556-0864

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    Publishing type:Research paper (scientific journal)  

  • Interstitial Lung Disease Induced by Osimertinib for Epidermal Growth Factor Receptor (EGFR) T790M-positive Non-small Cell Lung Cancer Reviewed

    Matsumoto Yoshiya, Kawaguchi Tomoya, Yamamoto Norio, Sawa Kenji, Yoshimoto Naoki, Suzumura Tomohiro, Watanabe Tetsuya, Mitsuoka Shigeki, Asai Kazuhisa, Kimura Tatsuo, Yoshimura Naruo, Kuwae Yuko, Hirata Kazuto

    一般社団法人 日本内科学会 INTERNAL MEDICINE   56 ( 17 )   2325 - 2328   2017( ISSN:0918-2918

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    Publishing type:Research paper (scientific journal)  

    <p>A 75-year-old man with stage IV lung adenocarcinoma was treated with osimertinib due to disease progression despite having been administered erlotinib. Both an epidermal growth factor receptor (EGFR) L858R mutation on exon 21 and a T790M mutation on exon 20 were detected in a specimen from a recurrent primary tumor. Five weeks after osimertinib initiation, he developed general fatigue and dyspnea. Chest computed tomography scan revealed diffuse ground glass opacities and consolidation on both lungs. An analysis of the bronchoalveolar lavage fluid revealed marked lymphocytosis, and a transbronchial lung biopsy specimen showed a thickened interstitium with fibrosis and prominent lymphocytic infiltration. We diagnosed the patient to have interstitial lung disease induced by osimertinib. </p>

    DOI: 10.2169/internalmedicine.8467-16

    PubMed

    CiNii Article

  • Molecular Epidemiological Study on Passive Smoking and Estrogen Receptor Expression in Never-smokers with Non-small Cell Lung Cancer. Reviewed

    Naoki Y, Kawaguchi T, Isa SI, Shimizu S, Tamiya A, Asai K, Kudoh S, Hirata K

    Osaka city medical journal   62 ( 2 )   77 - 84   2016.12( ISSN:0030-6096

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    PubMed

  • 喫煙経験のない非小細胞肺がん患者における受動喫煙とエストロゲン受容体の発現に関する分子疫学研究(Molecular Epidemiological Study on Passive Smoking and Estrogen Receptor Expression in Never-smokers with Non-small Cell Lung Cancer) Reviewed

    Yoshimoto Naoki, Kawaguchi Tomoya, Isa Shun-ichi, Shimizu Shigeki, Tamiya Akihiro, Asai Kazuhisa, Kudoh Shinzoh, Hirata Kazuto

    大阪市医学会 Osaka City Medical Journal   62 ( 2 )   77 - 84   2016.12( ISSN:0030-6096

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  • 喫煙経験のない非小細胞肺がん患者における受動喫煙とエストロゲン受容体の発現に関する分子疫学研究(Molecular Epidemiological Study on Passive Smoking and Estrogen Receptor Expression in Never-smokers with Non-small Cell Lung Cancer)

    Yoshimoto Naoki, Kawaguchi Tomoya, Isa Shun-ichi, Shimizu Shigeki, Tamiya Akihiro, Asai Kazuhisa, Kudoh Shinzoh, Hirata Kazuto

    Osaka City Medical Journal   62 ( 2 )   77 - 84   2016.12( ISSN:0030-6096

  • Molecular Epidemiological Study on Passive Smoking and Estrogen Receptor Expression in Never-smokers with Non-small Cell Lung Cancer.

    Naoki Y, Kawaguchi T, Isa SI, Shimizu S, Tamiya A, Asai K, Kudoh S, Hirata K

    Osaka city medical journal   62 ( 2 )   77 - 84   2016.12( ISSN:0030-6096

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  • COPD

    64 ( 10 )   961 - 968   2016.10( ISSN:04523458 ( eISSN:18821200

  • 胸膜病変を伴う後縦隔の原発性辺縁帯リンパ腫(Primary Marginal Zone Lymphoma in the Posterior Mediastinum with Pleural Involvement) Reviewed

    Shimizu Shigeki, Inoue Yasushi, Utsumi Tomoki, Okuma Tomohisa, Kawaguchi Tomoya, Kasai Takahiko, Munakata Satoru, Shibano Masaru, Atagi Shinji

    (一社)日本内科学会 Internal Medicine   55 ( 18 )   2673 - 2677   2016.09( ISSN:0918-2918

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    症例は84歳女性で、50歳時に乳癌に対する乳房切除の施行歴があった。かかりつけ医で実施した胸部X線で偶然に右胸水を認め、精査目的で当院に入院となった。胸部CTで、右胸部傍脊椎領域の後縦隔に腫瘤が認められ、後縦隔の外科的生検による病理学的検査、免疫染色、フローサイトメトリーにより辺縁帯リンパ腫が明らかになった。病変は後縦隔と右胸膜に局在していた。R-THP-COPレジメンを4コース行った後、縦隔病変に対して放射線療法を追加したところ、完全寛解に達した。放射線療法から3ヵ月後に再発がみられ、エトポシド+ソブゾキサン投与により治療した。その後2年以上経過しているが、再発は起きていない。

  • Alectinib-Induced Erythema Multiforme and Successful Rechallenge with Alectinib in a Patient with Anaplastic Lymphoma Kinase-Rearranged Lung Cancer. Reviewed

    Kimura T, Sowa-Osako J, Nakai T, Ohyama A, Kawaguchi T, Tsuruta D, Ohsawa M, Hirata K

    Case reports in oncology   9 ( 3 )   826 - 832   2016.09

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    DOI: 10.1159/000453314

    PubMed

  • Alectinib-Induced Erythema Multiforme and Successful Rechallenge with Alectinib in a Patient with Anaplastic Lymphoma Kinase-Rearranged Lung Cancer.

    Kimura T, Sowa-Osako J, Nakai T, Ohyama A, Kawaguchi T, Tsuruta D, Ohsawa M, Hirata K

    Case reports in oncology   9 ( 3 )   826 - 832   2016.09

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  • 胸膜病変を伴う後縦隔の原発性辺縁帯リンパ腫(Primary Marginal Zone Lymphoma in the Posterior Mediastinum with Pleural Involvement)

    Shimizu Shigeki, Inoue Yasushi, Utsumi Tomoki, Okuma Tomohisa, Kawaguchi Tomoya, Kasai Takahiko, Munakata Satoru, Shibano Masaru, Atagi Shinji

    Internal Medicine   55 ( 18 )   2673 - 2677   2016.09( ISSN:0918-2918

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    症例は84歳女性で、50歳時に乳癌に対する乳房切除の施行歴があった。かかりつけ医で実施した胸部X線で偶然に右胸水を認め、精査目的で当院に入院となった。胸部CTで、右胸部傍脊椎領域の後縦隔に腫瘤が認められ、後縦隔の外科的生検による病理学的検査、免疫染色、フローサイトメトリーにより辺縁帯リンパ腫が明らかになった。病変は後縦隔と右胸膜に局在していた。R-THP-COPレジメンを4コース行った後、縦隔病変に対して放射線療法を追加したところ、完全寛解に達した。放射線療法から3ヵ月後に再発がみられ、エトポシド+ソブゾキサン投与により治療した。その後2年以上経過しているが、再発は起きていない。

  • Prospective Analysis of Oncogenic Driver Mutations and Environmental Factors: Japan Molecular Epidemiology for Lung Cancer Study Reviewed

    Kawaguchi Tomoya, Koh Yasuhiro, Ando Masahiko, Ito Norimasa, Takeo Sadanori, Adachi Hirofumi, Tagawa Tsutomu, Kakegawa Seiichi, Yamashita Motohiro, Kataoka Kazuhiko, Ichinose Yukito, Takeuchi Yukiyasu, Serizawa Masakuni, Tamiya Akihiro, Shimizu Shigeki, Yoshimoto Naoki, Kubo Akihito, Isa Shun-ichi, Saka Hideo, Matsumura Akihide

    JOURNAL OF CLINICAL ONCOLOGY   34 ( 19 )   2247 - +   2016.07( ISSN:0732-183X

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    DOI: 10.1200/JCO.2015.64.2322

    PubMed

  • Prospective Analysis of Oncogenic Driver Mutations and Environmental Factors: Japan Molecular Epidemiology for Lung Cancer Study.

    Kawaguchi T, Koh Y, Ando M, Ito N, Takeo S, Adachi H, Tagawa T, Kakegawa S, Yamashita M, Kataoka K, Ichinose Y, Takeuchi Y, Serizawa M, Tamiya A, Shimizu S, Yoshimoto N, Kubo A, Isa S, Saka H, Matsumura A

    Journal of clinical oncology : official journal of the American Society of Clinical Oncology   34 ( 19 )   2247 - 57   2016.07( ISSN:0732-183X

  • Vascular Endothelial Growth Factor in Plasma and Pleural Effusion Is a Biomarker for Outcome After Bevacizumab plus Carboplatin-Paclitaxel Treatment for Non-small Cell Lung Cancer with Malignant Pleural Effusion Reviewed

    Tamiya Motohiro, Tamiya Akihiro, Yasue Tomomi, Nakao Keiko, Omachi Naoki, Shiroyama Takayuki, Tani Eriko, Hamaguchi Masanari, Morishita Naoko, Suzuki Hidekazu, Okamoto Norio, Okishio Kyoichi, Kawaguchi Tomoya, Atagi Shinji, Hirashima Tomonori

    ANTICANCER RESEARCH   36 ( 6 )   2939 - 2944   2016.06( ISSN:0250-7005

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  • Vascular Endothelial Growth Factor in Plasma and Pleural Effusion Is a Biomarker for Outcome After Bevacizumab plus Carboplatin-Paclitaxel Treatment for Non-small Cell Lung Cancer with Malignant Pleural Effusion. Reviewed

    Tamiya M, Tamiya A, Yasue T, Nakao K, Omachi N, Shiroyama T, Tani E, Hamaguchi M, Morishita N, Suzuki H, Okamoto N, Okishio K, Kawaguchi T, Atagi S, Hirashima T

    Anticancer research   36 ( 6 )   2939 - 44   2016.06( ISSN:0250-7005

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    PubMed

  • Vascular Endothelial Growth Factor in Plasma and Pleural Effusion Is a Biomarker for Outcome After Bevacizumab plus Carboplatin-Paclitaxel Treatment for Non-small Cell Lung Cancer with Malignant Pleural Effusion.

    Tamiya M, Tamiya A, Yasue T, Nakao K, Omachi N, Shiroyama T, Tani E, Hamaguchi M, Morishita N, Suzuki H, Okamoto N, Okishio K, Kawaguchi T, Atagi S, Hirashima T

    Anticancer research   36 ( 6 )   2939 - 44   2016.06( ISSN:0250-7005

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  • Mutational landscape of non-small cell lung cancer (NSCLC) associated with chronic obstructive pulmonary disease (COPD). Reviewed

    Kawaguchi Tomoya, Koh Yasuhiro, Ando Masahiko, Isa Shun-Ichi, Tamiya Akihiro, Kubo Akihito, Yoshimoto Naoki, Kitagawa Chiyoe, Saka Hideo, Hirata Kazuto, Matsumura Akihide

    JOURNAL OF CLINICAL ONCOLOGY   34 ( 15 )   2016.05( ISSN:0732-183X

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    DOI: 10.1200/JCO.2016.34.15_suppl.8526

  • Epidermal growth factor receptor tyrosine kinase inhibitors in previously treated advanced non-small-cell lung cancer with wild-type EGFR Reviewed

    Mitsuoka Shigeki, Kawaguchi Tomoya, Kubo Akihito, Isa Shun-ichi, Asai Kazuhisa, Uji Masato, Watanabe Tetsuya, Sawa Kenji, Yoshimoto Naoki, Oka Takako, Nakai Toshiyuki, Suzumura Tomohiro, Tanaka Hidenori, Matsuura Kuniomi, Kimura Tatsuo, Yoshimura Naruo, Kudoh Shinzoh, Hirata Kazuto

    EXPERT OPINION ON PHARMACOTHERAPY   17 ( 2 )   193 - 203   2016.01( ISSN:1465-6566

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    DOI: 10.1517/14656566.2016.1109635

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  • Prospective analysis on oncogenic driver mutations and environmental factors: Japan Molecular Epidemiology for lung cancer study (JME)

    Tomoya Kawaguchi, Yasuhiro Koh, Masahiko Ando, et al.

    J Clin Oncol   34   2247 - 2257   2016

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  • 北見ら"肺癌病巣に対する気管支鏡下生検後肺化膿症合併例の検討―合併症の予測と予防は可能か?―" Reviewed

    川口 知哉

    特定非営利活動法人 日本呼吸器内視鏡学会 気管支学   38 ( 6 )   474 - 475   2016

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    Publishing type:Research paper (scientific journal)   Kind of work:Single Work  

    DOI: 10.18907/jjsre.38.6_474

    CiNii Article

  • Primary Marginal Zone Lymphoma in the Posterior Mediastinum with Pleural Involvement. Reviewed

    Shimizu S, Inoue Y, Utsumi T, Okuma T, Kawaguchi T, Kasai T, Munakata S, Shibano M, Atagi S

    Internal medicine (Tokyo, Japan)   55 ( 18 )   2673 - 7   2016( ISSN:0918-2918

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    DOI: 10.2169/internalmedicine.55.6716

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  • 北見ら“肺癌病巣に対する気管支鏡下生検後肺化膿症合併例の検討―合併症の予測と予防は可能か?―”

    川口 知哉

    気管支学   38 ( 6 )   474 - 475   2016( ISSN:02872137 ( eISSN:21860149

  • Primary Marginal Zone Lymphoma in the Posterior Mediastinum with Pleural Involvement.

    Shimizu S, Inoue Y, Utsumi T, Okuma T, Kawaguchi T, Kasai T, Munakata S, Shibano M, Atagi S

    Internal medicine (Tokyo, Japan)   55 ( 18 )   2673 - 7   2016( ISSN:0918-2918

  • Epidermal growth factor receptor tyrosine kinase inhibitors in previously treated advanced non-small-cell lung cancer with wild-type EGFR.

    Mitsuoka S, Kawaguchi T, Kubo A, Isa S, Asai K, Uji M, Watanabe T, Sawa K, Yoshimoto N, Oka T, Nakai T, Suzumura T, Tanaka H, Matsuura K, Kimura T, Yoshimura N, Kudoh S, Hirata K

    Expert opinion on pharmacotherapy   17 ( 2 )   193 - 203   2016( ISSN:1465-6566

  • Randomized Phase II Study of Adjuvant Chemotherapy with Long-term S-1 versus Cisplatin+S-1 in Completely Resected Stage II-IIIA Non-Small Cell Lung Cancer Reviewed

    Iwamoto Yasuo, Mitsudomi Tetsuya, Sakai Kazuko, Yamanaka Takeharu, Yoshioka Hiroshige, Takahama Makoto, Yoshimura Masahiro, Yoshino Ichiro, Takeda Masayuki, Sugawara Shunichi, Kawaguchi Tomoya, Takahashi Toshiaki, Ohta Mitsunori, Ichinose Yukito, Atagi Shinji, Okada Morihito, Saka Hideo, Nakagawa Kazuhiko, Nakanishi Yoichi, Nishio Kazuto

    CLINICAL CANCER RESEARCH   21 ( 23 )   5245 - 5252   2015.12( ISSN:1078-0432

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    DOI: 10.1158/1078-0432.CCR-14-3160

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  • Randomized Phase II Study of Adjuvant Chemotherapy with Long-term S-1 versus Cisplatin+S-1 in Completely Resected Stage II-IIIA Non-Small Cell Lung Cancer.

    Iwamoto Y, Mitsudomi T, Sakai K, Yamanaka T, Yoshioka H, Takahama M, Yoshimura M, Yoshino I, Takeda M, Sugawara S, Kawaguchi T, Takahashi T, Ohta M, Ichinose Y, Atagi S, Okada M, Saka H, Nakagawa K, Nakanishi Y, Nishio K

    Clinical cancer research : an official journal of the American Association for Cancer Research   21 ( 23 )   5245 - 52   2015.12( ISSN:1078-0432

  • 非小細胞肺がんにおいてコンピュータ断層撮影支援により穿刺生検した検体の巨視的な様相は腫瘍の転移と相関している(The Macroscopic Appearance of Computed Tomography-guided Needle Biopsy Specimens Correlates with Tumor Metastasis in Non-small Cell Lung Cancer)

    Nakai Toshiyuki, Kimura Tatsuo, Suzumura Tomohiro, Yoshimoto Naoki, Oka Takako, Yamamoto Norio, Matsuura Kuniomi, Mitsuoka Shigeki, Asai Kazuhisa, Tochino Yoshihiro, Yoshimura Naruo, Kawaguchi Tomoya, Kudoh Shinzoh, Matsuoka Toshiyuki, Ohsawa Masahiko, Hirata Kazuto

    Osaka City Medical Journal   61 ( 2 )   105 - 112   2015.12( ISSN:0030-6096

  • Nedaplatin plus docetaxel versus cisplatin plus docetaxel for advanced or relapsed squamous cell carcinoma of the lung (WJOG5208L): a randomised, open-label, phase 3 trial Reviewed

    Shukuya Takehito, Yamanaka Takeharu, Seto Takashi, Daga Haruko, Goto Koichi, Saka Hideo, Sugawara Shunichi, Takahashi Toshiaki, Yokota Soichiro, Kaneda Hiroyasu, Kawaguchi Tomoya, Nagase Seisuke, Oguri Tetsuya, Iwamoto Yasuo, Nishimura Takashi, Hattori Yoshihiro, Nakagawa Kazuhiko, Nakanishi Yoichi, Yamamoto Nobuyuki

    LANCET ONCOLOGY   16 ( 16 )   1630 - 1638   2015.12( ISSN:1470-2045

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    DOI: 10.1016/S1470-2045(15)00305-8

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  • 非小細胞肺がんにおいてコンピュータ断層撮影支援により穿刺生検した検体の巨視的な様相は腫瘍の転移と相関している(The Macroscopic Appearance of Computed Tomography-guided Needle Biopsy Specimens Correlates with Tumor Metastasis in Non-small Cell Lung Cancer) Reviewed

    Nakai Toshiyuki, Kimura Tatsuo, Suzumura Tomohiro, Yoshimoto Naoki, Oka Takako, Yamamoto Norio, Matsuura Kuniomi, Mitsuoka Shigeki, Asai Kazuhisa, Tochino Yoshihiro, Yoshimura Naruo, Kawaguchi Tomoya, Kudoh Shinzoh, Matsuoka Toshiyuki, Ohsawa Masahiko, Hirata Kazuto

    大阪市医学会 Osaka City Medical Journal   61 ( 2 )   105 - 112   2015.12( ISSN:0030-6096

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  • The Macroscopic Appearance of Computed Tomography-guided Needle Biopsy Specimens Correlates with Tumor Metastasis in Non-small Cell Lung Cancer. Reviewed

    Toshiyuki N, Kimura T, Suzumura T, Yoshimoto N, Oka T, Yamamoto N, Matsuura K, Mitsuoka S, Asai K, Tochino Y, Yoshimura N, Kawaguchi T, Kudoh S, Matsuoka T, Ohsawa M, Hirata K

    Osaka city medical journal   61 ( 2 )   105 - 12   2015.12( ISSN:0030-6096

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    PubMed

  • The Macroscopic Appearance of Computed Tomography-guided Needle Biopsy Specimens Correlates with Tumor Metastasis in Non-small Cell Lung Cancer.

    Toshiyuki N, Kimura T, Suzumura T, Yoshimoto N, Oka T, Yamamoto N, Matsuura K, Mitsuoka S, Asai K, Tochino Y, Yoshimura N, Kawaguchi T, Kudoh S, Matsuoka T, Ohsawa M, Hirata K

    Osaka city medical journal   61 ( 2 )   105 - 12   2015.12( ISSN:0030-6096

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  • Nedaplatin plus docetaxel versus cisplatin plus docetaxel for advanced or relapsed squamous cell carcinoma of the lung (WJOG5208L): a randomised, open-label, phase 3 trial.

    Shukuya T, Yamanaka T, Seto T, Daga H, Goto K, Saka H, Sugawara S, Takahashi T, Yokota S, Kaneda H, Kawaguchi T, Nagase S, Oguri T, Iwamoto Y, Nishimura T, Hattori Y, Nakagawa K, Nakanishi Y, Yamamoto N, West Japan Oncology Group.

    The Lancet. Oncology   16 ( 16 )   1630 - 8   2015.12( ISSN:1470-2045

  • Phase II study of a combination regimen of gefitinib and pemetrexed as first-line treatment in patients with advanced non-small cell lung cancer harboring a sensitive EGFR mutation Reviewed

    Yoshimura Naruo, Kudoh Shinzoh, Mitsuoka Shigeki, Yoshimoto Naoki, Oka Takako, Nakai Toshiyuki, Suzumira Tomohiro, Matusura Kuniomi, Tochino Yoshihiro, Asai Kazuhisa, Kimura Tatsuo, Kawaguchi Tomoya, Hirata Kazuto

    LUNG CANCER   90 ( 1 )   65 - 70   2015.10( ISSN:0169-5002

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    DOI: 10.1016/j.lungcan.2015.06.002

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  • 急速に増大した致死的な前縦隔奇形腫(Life-threatening and Rapidly Growing Teratoma in the Anterior Mediastinum) Reviewed

    Omachi Naoki, Kawaguchi Tomoya, Shimizu Shigeki, Okuma Tomohisa, Kitaichi Masanori, Atagi Shinji, Yoon Hyung-Eun, Matsumura Akihide

    (一社)日本内科学会 Internal Medicine   54 ( 19 )   2487 - 2489   2015.10( ISSN:0918-2918

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    症例は23歳男性で、労作性呼吸困難を主訴に入院した。5ヵ月前の定期検診におけるX線検査では異常がみられなかったが、4ヵ月前に軽度の胸痛が突然出現し、胸部X線で右肺門腫大を認めた。入院時のX線検査では右肺野に広範な浸潤影を認めた。CTでは内部が不均一な葉状の巨大腫瘍が前縦隔から右胸腔に突出していた。MRI画像で複数の嚢胞を含む腫瘍が右房を圧迫、心臓と血管が左方偏位しているのを認めた。胸骨正中切開により緊急手術を施行した。腫瘍は前縦隔から胸腔内に破裂し、右中葉と心外膜に強く癒着していたが、出血または血管内浸潤は見られなかった。腫瘍の一括切除と右肺中葉と外心膜の部分切除を行った。腫瘍の大きさは231×145×93mmであった。肉眼所見で多発性嚢腫を認め、黄白色の皮脂物質と毛髪様物質を認めた。顕微鏡下では嚢胞性病変は扁平上皮で覆われ、その下には脂腺、平滑筋、毛、軟骨、膵組織が分布していた。腫瘍内に悪性腫瘍または未熟成分は見られなかった。以上の所見より良性の成熟奇形腫と診断した。

  • 急速に増大した致死的な前縦隔奇形腫(Life-threatening and Rapidly Growing Teratoma in the Anterior Mediastinum)

    Omachi Naoki, Kawaguchi Tomoya, Shimizu Shigeki, Okuma Tomohisa, Kitaichi Masanori, Atagi Shinji, Yoon Hyung-Eun, Matsumura Akihide

    Internal Medicine   54 ( 19 )   2487 - 2489   2015.10( ISSN:0918-2918

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    症例は23歳男性で、労作性呼吸困難を主訴に入院した。5ヵ月前の定期検診におけるX線検査では異常がみられなかったが、4ヵ月前に軽度の胸痛が突然出現し、胸部X線で右肺門腫大を認めた。入院時のX線検査では右肺野に広範な浸潤影を認めた。CTでは内部が不均一な葉状の巨大腫瘍が前縦隔から右胸腔に突出していた。MRI画像で複数の嚢胞を含む腫瘍が右房を圧迫、心臓と血管が左方偏位しているのを認めた。胸骨正中切開により緊急手術を施行した。腫瘍は前縦隔から胸腔内に破裂し、右中葉と心外膜に強く癒着していたが、出血または血管内浸潤は見られなかった。腫瘍の一括切除と右肺中葉と外心膜の部分切除を行った。腫瘍の大きさは231×145×93mmであった。肉眼所見で多発性嚢腫を認め、黄白色の皮脂物質と毛髪様物質を認めた。顕微鏡下では嚢胞性病変は扁平上皮で覆われ、その下には脂腺、平滑筋、毛、軟骨、膵組織が分布していた。腫瘍内に悪性腫瘍または未熟成分は見られなかった。以上の所見より良性の成熟奇形腫と診断した。

  • Phase II study of a combination regimen of gefitinib and pemetrexed as first-line treatment in patients with advanced non-small cell lung cancer harboring a sensitive EGFR mutation.

    Yoshimura N, Kudoh S, Mitsuoka S, Yoshimoto N, Oka T, Nakai T, Suzumira T, Matusura K, Tochino Y, Asai K, Kimura T, Kawaguchi T, Hirata K

    Lung cancer (Amsterdam, Netherlands)   90 ( 1 )   65 - 70   2015.10( ISSN:0169-5002

  • Ultra-Sensitive Detection of the Pretreatment EGFR T790M Mutation in Non-Small Cell Lung Cancer Patients with an EGFR-Activating Mutation Using Droplet Digital PCR Reviewed

    Watanabe Masaru, Kawaguchi Tomoya, Isa Shun-ichi, Ando Masahiko, Tamiya Akihiro, Kubo Akihito, Saka Hideo, Takeo Sadanori, Adachi Hirofumi, Tagawa Tsutomu, Kakegawa Seiichi, Yamashita Motohiro, Kataoka Kazuhiko, Ichinose Yukito, Takeuchi Yukiyasu, Sakamoto Kazuhiro, Matsumura Akihide, Koh Yasuhiro

    CLINICAL CANCER RESEARCH   21 ( 15 )   3552 - 3560   2015.08( ISSN:1078-0432

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    DOI: 10.1158/1078-0432.CCR-14-2151

    PubMed

  • Ultrasensitive detection of the pretreatment EGFR T790M mutation in non-small cell lung cancer patients with an EGFR-activating mutation using picodroplet digital PCR Reviewed

    Koh Yasuhiro, Kawaguchi Tomoya, Watanabe Masaru, Isa Shun-ichi, Ando Masahiko, Tamiya Akihiro, Kubo Akihito, Saka Hideo, Takeo Sadanori, Adach Hirofumi, Tagawa Tsutomu, Kakegawa Seiichi, Yamashita Motohiro, Kataoka Kazuhiko, Ichinose Yukito, Takeuchi Yukiyasu, Sakamoto Kazuhiro, Matsumura Akihide

    CANCER RESEARCH   75   2015.08( ISSN:0008-5472

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    DOI: 10.1158/1538-7445.AM2015-617

  • Ultra-Sensitive Detection of the Pretreatment EGFR T790M Mutation in Non-Small Cell Lung Cancer Patients with an EGFR-Activating Mutation Using Droplet Digital PCR.

    Watanabe M, Kawaguchi T, Isa S, Ando M, Tamiya A, Kubo A, Saka H, Takeo S, Adachi H, Tagawa T, Kakegawa S, Yamashita M, Kataoka K, Ichinose Y, Takeuchi Y, Sakamoto K, Matsumura A, Koh Y

    Clinical cancer research : an official journal of the American Association for Cancer Research   21 ( 15 )   3552 - 60   2015.08( ISSN:1078-0432

  • パゾパニブを投与した胸膜原発滑膜肉腫(Primary Pleural Synovial Sarcoma Treated with Pazopanib) Reviewed

    Sugitani Arata, Asai Kazuhisa, Kojima Kazuya, Eguchi Yosuke, Kawaguchi Tomoya, Ohsawa Masahiko, Hirata Kazuto

    (一社)日本内科学会 Internal Medicine   54 ( 16 )   2051 - 2055   2015.08( ISSN:0918-2918

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    症例は42歳女性で、胸痛と息切れのため当院外来を受診した。初回の胸部CTで右肺基底部に2×2cmの結節を認めた。気管支鏡検査では悪性所見はみられなかったが、14日後に呼吸困難が出現し、救急部に来院した。CTで肥大した腫瘍と右胸水を認めた。右腋窩第4肋間からのビデオ補助下胸腔鏡手術で右下葉に巨大な腫瘤と、血清胸水、胸膜播種性転移が明らかになった。胸膜播種性転移部から採取した生検標本の病理学的検査と免疫染色の結果、胸膜滑膜肉腫と診断した。PETで骨盤への全身性転移が検出されたため、ファーストライン療法としてドキソルビシン+イホスファミドを投与したところ、腫瘍は一時的に縮小したがその後増大した。そこで、セカンドライン療法としてパゾパニブを投与したが、発症から8ヵ月後に死亡した。

  • パゾパニブを投与した胸膜原発滑膜肉腫(Primary Pleural Synovial Sarcoma Treated with Pazopanib)

    Sugitani Arata, Asai Kazuhisa, Kojima Kazuya, Eguchi Yosuke, Kawaguchi Tomoya, Ohsawa Masahiko, Hirata Kazuto

    Internal Medicine   54 ( 16 )   2051 - 2055   2015.08( ISSN:0918-2918

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    症例は42歳女性で、胸痛と息切れのため当院外来を受診した。初回の胸部CTで右肺基底部に2×2cmの結節を認めた。気管支鏡検査では悪性所見はみられなかったが、14日後に呼吸困難が出現し、救急部に来院した。CTで肥大した腫瘍と右胸水を認めた。右腋窩第4肋間からのビデオ補助下胸腔鏡手術で右下葉に巨大な腫瘤と、血清胸水、胸膜播種性転移が明らかになった。胸膜播種性転移部から採取した生検標本の病理学的検査と免疫染色の結果、胸膜滑膜肉腫と診断した。PETで骨盤への全身性転移が検出されたため、ファーストライン療法としてドキソルビシン+イホスファミドを投与したところ、腫瘍は一時的に縮小したがその後増大した。そこで、セカンドライン療法としてパゾパニブを投与したが、発症から8ヵ月後に死亡した。

  • Individual patients data analysis (IPD) of three randomized studies comparing erlotinib (E) with chemotherapy (CT) in patients with advanced wild-type epidermal growth factor receptor (wtEGFR) non-small cell lung cancer (NSCLC). Reviewed

    Torri Valter, Ando Masahiko, Rulli Eliana, Floriani Irene Claudia, Kawaguchi Tomoya, Isa Shun-ichi, Gregorc Vanesa, Novello Silvia, Barni Sandro, Cinquini Michela, Marsoni Silvia, Farina Gabriella, Garassino Marina Chiara

    JOURNAL OF CLINICAL ONCOLOGY   33 ( 15 )   2015.05( ISSN:0732-183X

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  • Randomized phase III study of nedaplatin (N) plus docetaxel (D) versus cisplatin (C) plus D for advanced or relapsed squamous cell carcinoma of the lung (SqLC): WJOG5208L. Reviewed

    Shukuya Takehito, Yamanaka Takeharu, Seto Takashi, Daga Haruko, Goto Koichi, Saka Hideo, Sugawara Shunichi, Takahashi Toshiaki, Yokota Soichiro, Kaneda Hiroyasu, Kawaguchi Tomoya, Nagase Seisuke, Oguri Tetsuya, Iwamoto Yasuo, Nishimura Takashi, Hattori Yoshihiro, Nakagawa Kazuhiko, Nakanishi Yoichi, Yamamoto Nobuyuki

    JOURNAL OF CLINICAL ONCOLOGY   33 ( 15 )   2015.05( ISSN:0732-183X

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  • Integrative analysis on expression of estrogen, environmental tobacco smoke and EGFR mutations from a prospective cohort study for never-smokers with non-small cell lung cancer. Reviewed

    Yoshimoto Naoki, Kawaguchi Tomoya, Tamiya Akihiro, Isa Shun-ichi, Shimizu Shigeki, Asai Kazuhisa, Kudoh Shinzoh, Hirata Kazuto

    JOURNAL OF CLINICAL ONCOLOGY   33 ( 15 )   2015.05( ISSN:0732-183X

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  • 大量胸水を伴う肺動脈の血管内滑膜肉腫 イホスファミド化学療法と緩和放射線療法が奏効した1症例報告(Intravascular Synovial Sarcoma of the Pulmonary Artery with Massive Pleural Effusion: Report of a Case with a Favorable Response to Ifosfamide Chemotherapy and Palliative Radiation Therapy) Reviewed

    Maekura Toshiya, Shimizu Shigeki, Kawaguchi Tomoya, Morimoto Masahiro, Okuma Tomohisa, Matsui Hideo, Atagi Shinji

    (一社)日本内科学会 Internal Medicine   54 ( 9 )   1095 - 1098   2015.05( ISSN:0918-2918

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    症例は23歳女性で、身体検査で胸骨左縁の収縮期雑音と右肺上の呼吸音減弱が認められた。胸部レントゲンで大量の右側胸水が検出され、心エコーで右肺動脈から肺動脈幹にかけて拡大する腫瘍が明らかになった。さらに、コントラスト増強CTで右胸膜に散乱する病変がみられ、PET-CTでは当該病変内のFDG取込み増強が認められた。胸膜病変部の生検で均一に短い紡錘細胞の増殖が示され、逆転写PCR法でSYT-SSX融合遺伝子が検出された。胸水内に悪性細胞は検出されなかったが、病理学的所見から本腫瘍は滑膜肉腫であることが示された。肺動脈幹の閉塞を防ぐため縦隔に対して緩和放射線療法を施行し、さらにイホスファミド10g/m2持続注入を行ったところ、腫瘍増殖と胸水が減少した。

  • 大量胸水を伴う肺動脈の血管内滑膜肉腫 イホスファミド化学療法と緩和放射線療法が奏効した1症例報告(Intravascular Synovial Sarcoma of the Pulmonary Artery with Massive Pleural Effusion: Report of a Case with a Favorable Response to Ifosfamide Chemotherapy and Palliative Radiation Therapy)

    Maekura Toshiya, Shimizu Shigeki, Kawaguchi Tomoya, Morimoto Masahiro, Okuma Tomohisa, Matsui Hideo, Atagi Shinji

    Internal Medicine   54 ( 9 )   1095 - 1098   2015.05( ISSN:0918-2918

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    症例は23歳女性で、身体検査で胸骨左縁の収縮期雑音と右肺上の呼吸音減弱が認められた。胸部レントゲンで大量の右側胸水が検出され、心エコーで右肺動脈から肺動脈幹にかけて拡大する腫瘍が明らかになった。さらに、コントラスト増強CTで右胸膜に散乱する病変がみられ、PET-CTでは当該病変内のFDG取込み増強が認められた。胸膜病変部の生検で均一に短い紡錘細胞の増殖が示され、逆転写PCR法でSYT-SSX融合遺伝子が検出された。胸水内に悪性細胞は検出されなかったが、病理学的所見から本腫瘍は滑膜肉腫であることが示された。肺動脈幹の閉塞を防ぐため縦隔に対して緩和放射線療法を施行し、さらにイホスファミド10g/m2持続注入を行ったところ、腫瘍増殖と胸水が減少した。

  • The Role of Smoking Status on the Progression-Free Survival of Non-Small Cell Lung Cancer Patients Harboring Activating Epidermal Growth Factor Receptor (EGFR) Mutations Receiving First-Line EGFR Tyrosine Kinase Inhibitor Versus Platinum Doublet Chemotherapy: A Meta-Analysis of Prospective Randomized Trials Reviewed

    Hasegawa Yoshikazu, Ando Masahiko, Maemondo Makoto, Yamamoto Satomi, Isa Shun-ichi, Saka Hideo, Kubo Akihito, Kawaguchi Tomoya, Takada Minoru, Rosell Rafael, Kurata Takayasu, Ou Sai-Hong Ignatius

    ONCOLOGIST   20 ( 3 )   307 - 315   2015.03( ISSN:1083-7159

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    DOI: 10.1634/theoncologist.2014-0285

    PubMed

  • The role of smoking status on the progression-free survival of non-small cell lung cancer patients harboring activating epidermal growth factor receptor (EGFR) mutations receiving first-line EGFR tyrosine kinase inhibitor versus platinum doublet chemotherapy: a meta-analysis of prospective randomized trials.

    Hasegawa Y, Ando M, Maemondo M, Yamamoto S, Isa S, Saka H, Kubo A, Kawaguchi T, Takada M, Rosell R, Kurata T, Ou SH

    The oncologist   20 ( 3 )   307 - 15   2015.03( ISSN:1083-7159

  • Erlotinib Versus Docetaxel As Second- or Third-Line Therapy in Patients With Advanced Non-Small-Cell Lung Cancer in the Era of Personalized Medicine Reply Reviewed

    Kawaguchi Tomoya, Ando Masahiko, Kubo Akihito

    JOURNAL OF CLINICAL ONCOLOGY   33 ( 5 )   526 - U205   2015.02( ISSN:0732-183X

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    DOI: 10.1200/JCO.2014.58.5315

    PubMed

  • Reply to G. Spitzer and M.A. Socinski, F. Zhou et al, and B. Biswas.

    Kawaguchi T, Ando M, Kubo A

    Journal of clinical oncology : official journal of the American Society of Clinical Oncology   33 ( 5 )   526 - 7   2015.02( ISSN:0732-183X

  • Molecular analysis of human papillomavirus in never-smokers with non-small cell lung cancer Reviewed

    Isa Shun-Ichi, Kurahara Yu, Yamamoto Satomi, Tamiya Akihiro, Omachi Naoki, Asami Kazuhiro, Okishio Kyoichi, Utsumi Tomoki, Ito Norimasa, Yoon Hyung-Eun, Matsumura Akihide, Atagi Shinji, Kawaguchi Tomoya

    ONCOLOGY LETTERS   9 ( 2 )   927 - 929   2015.02( ISSN:1792-1074

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    DOI: 10.3892/ol.2014.2713

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  • Molecular analysis of human papillomavirus in never-smokers with non-small cell lung cancer.

    Isa SI, Kurahara Y, Yamamoto S, Tamiya A, Omachi N, Asami K, Okishio K, Utsumi T, Ito N, Yoon HE, Matsumura A, Atagi S, Kawaguchi T

    Oncology letters   9 ( 2 )   927 - 929   2015.02( ISSN:1792-1074

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  • Primary Pleural Synovial Sarcoma Treated with Pazopanib Reviewed

    Sugitani Arata, Asai Kazuhisa, Kojima Kazuya, Eguchi Yosuke, Kawaguchi Tomoya, Ohsawa Masahiko, Hirata Kazuto

    The Japanese Society of Internal Medicine INTERNAL MEDICINE   54 ( 16 )   2051 - 2055   2015( ISSN:0918-2918

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    A 42-year-old woman presented with chest pain and breathlessness with a nodule measuring 2×2 cm in size at the base of the right lung. A bronchoscopic examination did not reveal any malignancy. However, the patient developed difficulty in breathing, enlargement of the nodule, and right pleural effusion 14 days later. A video-assisted thoracic surgical biopsy specimen revealed the presence of pleural synovial sarcoma. The patient was treated with doxorubicin-ifosfamide combination chemotherapy because of metastasis to the pelvis. However, after a transient partial clinical response, there was a relapse of refractory disease. Although treated with pazopanib as second-line chemotherapy, the patient died eight months after the initial presentation.<br>

    DOI: 10.2169/internalmedicine.54.3570

    PubMed

    CiNii Article

  • Life-threatening and Rapidly Growing Teratoma in the Anterior Mediastinum Reviewed

    Omachi Naoki, Kawaguchi Tomoya, Shimizu Shigeki, Okuma Tomohisa, Kitaichi Masanori, Atagi Shinji, Yoon Hyung-Eun, Matsumura Akihide

    The Japanese Society of Internal Medicine INTERNAL MEDICINE   54 ( 19 )   2487 - 2489   2015( ISSN:0918-2918

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    This report describes the case of a 23-year-old man with a mediastinal teratoma. Five months before admission, a chest radiograph during a routine health checkup was normal. Four months before admission, the patient developed sudden onset of mild right-sided chest pain. He gradually developed dyspnea and was admitted to our hospital. Computed tomography revealed a giant tumor that was markedly compressing the right atrium. Urgent surgery was performed, and a ruptured, benign mature teratoma was diagnosed. Mature mediastinal teratomas are benign tumors, but they can rupture and have the potential to grow rapidly, potentially leading to life-threatening complications.<br>

    DOI: 10.2169/internalmedicine.54.4622

    PubMed

    CiNii Article

  • Intravascular Synovial Sarcoma of the Pulmonary Artery with Massive Pleural Effusion: Report of a Case with a Favorable Response to Ifosfamide Chemotherapy and Palliative Radiation Therapy Reviewed

    Maekura Toshiya, Shimizu Shigeki, Kawaguchi Tomoya, Morimoto Masahiro, Okuma Tomohisa, Matsui Hideo, Atagi Shinji

    INTERNAL MEDICINE   54 ( 9 )   1095 - 1098   2015( ISSN:0918-2918

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    DOI: 10.2169/internalmedicine.54.3624

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  • Ultra-sensitive detection of the pretreatment EGFR T790M mutation in non-small-cell lung cancer patients with an EGFR-activating mutation using picodroplet digital PCR

    M. Watanabe, T. Kawaguchi, S. Isa, et al.

    Clinical Cancer Res   21   3552 - 3560   2015

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  • Primary Pleural Synovial Sarcoma Treated with Pazopanib

    Sugitani Arata, Asai Kazuhisa, Kojima Kazuya, Eguchi Yosuke, Kawaguchi Tomoya, Ohsawa Masahiko, Hirata Kazuto

    Internal Medicine   54 ( 16 )   2051 - 5   2015( ISSN:0918-2918 ( eISSN:13497235

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    A 42-year-old woman presented with chest pain and breathlessness with a nodule measuring 2×2 cm in size at the base of the right lung. A bronchoscopic examination did not reveal any malignancy. However, the patient developed difficulty in breathing, enlargement of the nodule, and right pleural effusion 14 days later. A video-assisted thoracic surgical biopsy specimen revealed the presence of pleural synovial sarcoma. The patient was treated with doxorubicin-ifosfamide combination chemotherapy because of metastasis to the pelvis. However, after a transient partial clinical response, there was a relapse of refractory disease. Although treated with pazopanib as second-line chemotherapy, the patient died eight months after the initial presentation.<br>

    DOI: 10.2169/internalmedicine.54.3570

    PubMed

    CiNii Article

  • Life-threatening and Rapidly Growing Teratoma in the Anterior Mediastinum

    Omachi Naoki, Kawaguchi Tomoya, Shimizu Shigeki, Okuma Tomohisa, Kitaichi Masanori, Atagi Shinji, Yoon Hyung-Eun, Matsumura Akihide

    Internal Medicine   54 ( 19 )   2487 - 9   2015( ISSN:0918-2918 ( eISSN:13497235

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    This report describes the case of a 23-year-old man with a mediastinal teratoma. Five months before admission, a chest radiograph during a routine health checkup was normal. Four months before admission, the patient developed sudden onset of mild right-sided chest pain. He gradually developed dyspnea and was admitted to our hospital. Computed tomography revealed a giant tumor that was markedly compressing the right atrium. Urgent surgery was performed, and a ruptured, benign mature teratoma was diagnosed. Mature mediastinal teratomas are benign tumors, but they can rupture and have the potential to grow rapidly, potentially leading to life-threatening complications.<br>

    DOI: 10.2169/internalmedicine.54.4622

    PubMed

    CiNii Article

  • Intravascular Synovial Sarcoma of the Pulmonary Artery with Massive Pleural Effusion: Report of a Case with a Favorable Response to Ifosfamide Chemotherapy and Palliative Radiation Therapy

    Maekura Toshiya, Shimizu Shigeki, Kawaguchi Tomoya, Morimoto Masahiro, Okuma Tomohisa, Matsui Hideo, Atagi Shinji

    Internal Medicine   54 ( 9 )   1095 - 8   2015( ISSN:0918-2918 ( eISSN:13497235

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    Synovial sarcoma (SS) commonly arises in the para-articular soft tissue; however, very few cases of intravascular SS have so far been reported. We herein describe a case of pulmonary artery SS with massive pleural effusion. A biopsy of the pleural lesions showed uniform short spindle cell proliferation, while the <i>SYT-SSX</i> fusion gene, which is preceded by chromosomal translocation t(X;18)(p11;q11), was detected using reverse transcription-polymerase chain reaction. Treatment with ifosfamide chemotherapy and palliative radiation therapy was effective in reducing the growth of the tumor in the pulmonary artery and pleural lesions, indicating that this regimen may be useful for the treatment of unresectable SS in the pulmonary artery.<br>

    DOI: 10.2169/internalmedicine.54.3624

    PubMed

    CiNii Article

  • シスプラチンおよびゲムシタビンによる播種性肺多形細胞癌患者における長期完全寛解(Long-term Complete Response in a Patient with Disseminated Pulmonary Pleomorphic Carcinoma Induced by Cisplatin and Gemcitabine) Reviewed

    Tamiya Akihiro, Asami Kazuhiro, Shimizu Shigeki, Matsumura Akihide, Isa Shun-ichi, Okishio Kyoichi, Kitaichi Masanori, Atagi Shinji, Takada Minoru, Kawaguchi Tomoya, Kubo Akihito

    (一社)日本内科学会 Internal Medicine   53 ( 22 )   2625 - 2628   2014.11( ISSN:0918-2918

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    47歳男。肺の多形細胞癌に対する根治的手術から6週間後に、胸膜への播種を伴う肺と肝臓の多発性転移を呈し、当科を受診した。併用化学療法2種類(S-1とイリノテカン、カルボプラチンとパクリタキセル)を行なったが、どちらも疾患の進行に繋がった。全身状態が良好であったことから、シスプラチンとゲムシタビン(GEM)による化学療法を行なった結果、転移病変は6コース終了後に完全寛解を示した。その後6年以上にわたり再発はみられなかった。免疫組織化学的分析の結果、腫瘍はGEM輸送体のヒト受動拡散型ヌクレオシド受容体1を高発現していた。

  • シスプラチンおよびゲムシタビンによる播種性肺多形細胞癌患者における長期完全寛解(Long-term Complete Response in a Patient with Disseminated Pulmonary Pleomorphic Carcinoma Induced by Cisplatin and Gemcitabine)

    Tamiya Akihiro, Asami Kazuhiro, Shimizu Shigeki, Matsumura Akihide, Isa Shun-ichi, Okishio Kyoichi, Kitaichi Masanori, Atagi Shinji, Takada Minoru, Kawaguchi Tomoya, Kubo Akihito

    Internal Medicine   53 ( 22 )   2625 - 2628   2014.11( ISSN:0918-2918

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    47歳男。肺の多形細胞癌に対する根治的手術から6週間後に、胸膜への播種を伴う肺と肝臓の多発性転移を呈し、当科を受診した。併用化学療法2種類(S-1とイリノテカン、カルボプラチンとパクリタキセル)を行なったが、どちらも疾患の進行に繋がった。全身状態が良好であったことから、シスプラチンとゲムシタビン(GEM)による化学療法を行なった結果、転移病変は6コース終了後に完全寛解を示した。その後6年以上にわたり再発はみられなかった。免疫組織化学的分析の結果、腫瘍はGEM輸送体のヒト受動拡散型ヌクレオシド受容体1を高発現していた。

  • ステロイドの先行投与とバルーンカテーテル併用により容易に除去が可能となった気管支異物の1例 Reviewed

    辻 泰佑, 杉本 親寿, 山本 聡美, 杜倉 紗代子, 大町 直樹, 新井 徹, 川口 知哉, 井上 義一, 林 清二

    (NPO)日本呼吸器内視鏡学会 気管支学   36 ( 5 )   487 - 491   2014.09( ISSN:0287-2137

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    背景. 事前の短期ステロイド投与とバルーンカテーテルの使用により、容易に摘出が可能となった歯冠継続歯の気管支異物の1例を経験したので、報告する。症例. 64歳女性。発熱と倦怠感のため、近医で撮影された胸部X線写真で右下肺野に異物を認めた。胸部CTでは右底幹に異物の陥入を認めた。軟性気管支鏡による異物除去を試みたが、気管支粘膜の浮腫と肉芽の形成が高度で異物が底幹に嵌頓し、容易に出血するため初回の異物摘出術では摘出できなかった。抗菌薬に加え、ステロイドを投与した後、2度目の異物摘出術を行った。初回の異物摘出術の際に認めた粘膜の浮腫や肉芽は著明に改善を認めた。しかし、鉗子による異物の把持が困難であり、バルーンカテーテルを用いて中枢側に引き出し容易に摘出が可能であった。異物は歯冠継続歯であった。結論. 気管支内に陥入してから長期間経過している異物の場合、これらの方法が考慮されると考える。(著者抄録)

  • ステロイドの先行投与とバルーンカテーテル併用により容易に除去が可能となった気管支異物の1例

    辻 泰佑, 杉本 親寿, 山本 聡美, 杜倉 紗代子, 大町 直樹, 新井 徹, 川口 知哉, 井上 義一, 林 清二

    気管支学   36 ( 5 )   487 - 491   2014.09( ISSN:0287-2137

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    背景. 事前の短期ステロイド投与とバルーンカテーテルの使用により、容易に摘出が可能となった歯冠継続歯の気管支異物の1例を経験したので、報告する。症例. 64歳女性。発熱と倦怠感のため、近医で撮影された胸部X線写真で右下肺野に異物を認めた。胸部CTでは右底幹に異物の陥入を認めた。軟性気管支鏡による異物除去を試みたが、気管支粘膜の浮腫と肉芽の形成が高度で異物が底幹に嵌頓し、容易に出血するため初回の異物摘出術では摘出できなかった。抗菌薬に加え、ステロイドを投与した後、2度目の異物摘出術を行った。初回の異物摘出術の際に認めた粘膜の浮腫や肉芽は著明に改善を認めた。しかし、鉗子による異物の把持が困難であり、バルーンカテーテルを用いて中枢側に引き出し容易に摘出が可能であった。異物は歯冠継続歯であった。結論. 気管支内に陥入してから長期間経過している異物の場合、これらの方法が考慮されると考える。(著者抄録)

  • Randomized phase III trial of erlotinib versus docetaxel as second- or third-line therapy in patients with advanced non-small-cell lung cancer: Docetaxel and Erlotinib Lung Cancer Trial (DELTA). Reviewed

    Kawaguchi T, Ando M, Asami K, Okano Y, Fukuda M, Nakagawa H, Ibata H, Kozuki T, Endo T, Tamura A, Kamimura M, Sakamoto K, Yoshimi M, Soejima Y, Tomizawa Y, Isa S, Takada M, Saka H, Kubo A

    Journal of clinical oncology : official journal of the American Society of Clinical Oncology   32 ( 18 )   1902 - 8   2014.06( ISSN:0732-183X

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    DOI: 10.1200/JCO.2013.52.4694

    PubMed

  • Randomized phase III trial of erlotinib versus docetaxel as second- or third-line therapy in patients with advanced non-small-cell lung cancer: Docetaxel and Erlotinib Lung Cancer Trial (DELTA).

    Kawaguchi T, Ando M, Asami K, Okano Y, Fukuda M, Nakagawa H, Ibata H, Kozuki T, Endo T, Tamura A, Kamimura M, Sakamoto K, Yoshimi M, Soejima Y, Tomizawa Y, Isa S, Takada M, Saka H, Kubo A

    Journal of clinical oncology : official journal of the American Society of Clinical Oncology   32 ( 18 )   1902 - 8   2014.06( ISSN:0732-183X

  • [Discussion. Meeting on the diagnosis and treatment of lung cancer]. Reviewed

    Hirata K, Takayama K, Kawaguchi T, Sawa K, Ohsaki Y

    Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine   103 ( 6 )   1360 - 74; quiz 1375   2014.06( ISSN:0021-5384

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  • A case of large-cell neuroendocrine carcinoma harboring an EML4-ALK rearrangement with resistance to the ALK inhibitor crizotinib. Reviewed

    Omachi N, Shimizu S, Kawaguchi T, Tezuka K, Kanazu M, Tamiya A, Asami K, Okishio K, Kitaichi M, Atagi S

    Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer   9 ( 6 )   e40 - 2   2014.06( ISSN:1556-0864

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    DOI: 10.1097/JTO.0000000000000103

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  • A case of large-cell neuroendocrine carcinoma harboring an EML4-ALK rearrangement with resistance to the ALK inhibitor crizotinib.

    Omachi N, Shimizu S, Kawaguchi T, Tezuka K, Kanazu M, Tamiya A, Asami K, Okishio K, Kitaichi M, Atagi S

    Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer   9 ( 6 )   e40 - 2   2014.06( ISSN:1556-0864

  • Time-resolved coherent diffraction of ultrafast structural dynamics in a single nanowire.

    Newton MC, Sao M, Fujisawa Y, Onitsuka R, Kawaguchi T, Tokuda K, Sato T, Togashi T, Yabashi M, Ishikawa T, Ichitsubo T, Matsubara E, Tanaka Y, Nishino Y

    Nano letters   14 ( 5 )   2413 - 8   2014.05( ISSN:1530-6984

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  • Carboplatinとpaclitaxelに反応している肺粘液性類表皮癌の1症例(A Case of Pulmonary Mucoepidermoid Carcinoma Responding to Carboplatin and Paclitaxel) Reviewed

    Sonobe Shoko, Inoue Koji, Tachibana Sayaka, Shiojiri Masaaki, Maeda Toshiharu, Nakanishi Norihiko, Moritaka Tomonori, Ikura Yoshihiro, Kawaguchi Tomoya

    Oxford University Press Japanese Journal of Clinical Oncology   44 ( 5 )   493 - 496   2014.05( ISSN:0368-2811

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    呼吸困難と咳嗽を主訴とする59歳男性症例について検討した。下部気管にポリープ状腫瘍が観察され、スネアを用いて気管支鏡的ポリープ切除術を施行した。気管支鏡的切除で採取した断片的標本の組織検査にて、高グレードの粘液性類表皮癌と診断された。気管と主気管支に原発性病変を認め、肺に複数転移していた。Carboplatinとpaclitaxelの併用療法を実施した。4サイクルの化学療法後、腫瘍は有意に縮小した。25ヵ月経過時点で腫瘍進行のエビデンスもなく、患者の状態は良好であった。

  • A case of pulmonary mucoepidermoid carcinoma responding to carboplatin and paclitaxel. Reviewed

    Sonobe S, Inoue K, Tachibana S, Shiojiri M, Maeda T, Nakanishi N, Moritaka T, Ikura Y, Kawaguchi T

    Japanese journal of clinical oncology   44 ( 5 )   493 - 6   2014.05( ISSN:0368-2811

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    DOI: 10.1093/jjco/hyu016

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  • Early pharmacodynamic assessment using ¹⁸F-fluorodeoxyglucose positron-emission tomography on molecular targeted therapy and cytotoxic chemotherapy for clinical outcome prediction. Reviewed

    Kanazu M, Maruyama K, Ando M, Asami K, Ishii M, Uehira K, Minomo S, Matsuda Y, Kawaguchi T, Atagi S, Ogawa Y, Kusunoki Y, Takada M, Kubo A

    Clinical lung cancer   15 ( 3 )   182 - 7   2014.05( ISSN:1525-7304

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    DOI: 10.1016/j.cllc.2014.01.001

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  • A case of pulmonary mucoepidermoid carcinoma responding to carboplatin and paclitaxel.

    Sonobe S, Inoue K, Tachibana S, Shiojiri M, Maeda T, Nakanishi N, Moritaka T, Ikura Y, Kawaguchi T

    Japanese journal of clinical oncology   44 ( 5 )   493 - 6   2014.05( ISSN:0368-2811

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  • Early pharmacodynamic assessment using ¹⁸F-fluorodeoxyglucose positron-emission tomography on molecular targeted therapy and cytotoxic chemotherapy for clinical outcome prediction.

    Kanazu M, Maruyama K, Ando M, Asami K, Ishii M, Uehira K, Minomo S, Matsuda Y, Kawaguchi T, Atagi S, Ogawa Y, Kusunoki Y, Takada M, Kubo A

    Clinical lung cancer   15 ( 3 )   182 - 7   2014.05( ISSN:1525-7304

  • Carboplatinとpaclitaxelに反応している肺粘液性類表皮癌の1症例(A Case of Pulmonary Mucoepidermoid Carcinoma Responding to Carboplatin and Paclitaxel)

    Sonobe Shoko, Inoue Koji, Tachibana Sayaka, Shiojiri Masaaki, Maeda Toshiharu, Nakanishi Norihiko, Moritaka Tomonori, Ikura Yoshihiro, Kawaguchi Tomoya

    Japanese Journal of Clinical Oncology   44 ( 5 )   493 - 496   2014.05( ISSN:0368-2811

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    呼吸困難と咳嗽を主訴とする59歳男性症例について検討した。下部気管にポリープ状腫瘍が観察され、スネアを用いて気管支鏡的ポリープ切除術を施行した。気管支鏡的切除で採取した断片的標本の組織検査にて、高グレードの粘液性類表皮癌と診断された。気管と主気管支に原発性病変を認め、肺に複数転移していた。Carboplatinとpaclitaxelの併用療法を実施した。4サイクルの化学療法後、腫瘍は有意に縮小した。25ヵ月経過時点で腫瘍進行のエビデンスもなく、患者の状態は良好であった。

  • A pilot study of cisplatin and etoposide with and without radiotherapy for advanced malignant thymoma. Reviewed

    Tamiya A, Matsumura A, Tsuji T, Morimoto M, Asami K, Okishio K, Shimizu S, Yoon HE, Atagi S, Akira M, Kitaichi M, Kawaguchi T

    Anticancer research   34 ( 4 )   2023 - 7   2014.04( ISSN:0250-7005

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  • A pilot study of cisplatin and etoposide with and without radiotherapy for advanced malignant thymoma.

    Tamiya A, Matsumura A, Tsuji T, Morimoto M, Asami K, Okishio K, Shimizu S, Yoon HE, Atagi S, Akira M, Kitaichi M, Kawaguchi T

    Anticancer research   34 ( 4 )   2023 - 7   2014.04( ISSN:0250-7005

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  • Stratification of malignant pleural mesothelioma prognosis using recursive partitioning analysis. Reviewed

    Suzuki H, Asami K, Hirashima T, Okamoto N, Yamadori T, Tamiya M, Morishita N, Shiroyama T, Takeoka S, Osa A, Azuma Y, Okishio K, Kawaguchi T, Atagi S, Kawase I

    Lung   192 ( 1 )   191 - 5   2014.02( ISSN:0341-2040

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    DOI: 10.1007/s00408-013-9516-y

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  • Stratification of malignant pleural mesothelioma prognosis using recursive partitioning analysis.

    Suzuki H, Asami K, Hirashima T, Okamoto N, Yamadori T, Tamiya M, Morishita N, Shiroyama T, Takeoka S, Osa A, Azuma Y, Okishio K, Kawaguchi T, Atagi S, Kawase I

    Lung   192 ( 1 )   191 - 5   2014.02( ISSN:0341-2040

  • Human papilloma virus in non-small cell lung cancer in never smokers: a systematic review of the literature. Reviewed

    Hasegawa Y, Ando M, Kubo A, Isa S, Yamamoto S, Tsujino K, Kurata T, Ou SH, Takada M, Kawaguchi T

    Lung cancer (Amsterdam, Netherlands)   83 ( 1 )   8 - 13   2014.01( ISSN:0169-5002

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    DOI: 10.1016/j.lungcan.2013.10.002

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  • Role of consolidation chemotherapy after concurrent chemo-radiotherapy in locally advanced non-small-cell lung cancer. Reviewed

    Tsujino K, Kurata T, Kawaguchi T, Kubo A, Takada M, Ando M

    Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer   9 ( 1 )   e7 - 8   2014.01( ISSN:1556-0864

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1097/JTO.0000000000000035

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  • Human papilloma virus in non-small cell lung cancer in never smokers: a systematic review of the literature.

    Hasegawa Y, Ando M, Kubo A, Isa S, Yamamoto S, Tsujino K, Kurata T, Ou SH, Takada M, Kawaguchi T

    Lung cancer (Amsterdam, Netherlands)   83 ( 1 )   8 - 13   2014.01( ISSN:0169-5002

  • Role of consolidation chemotherapy after concurrent chemo-radiotherapy in locally advanced non-small-cell lung cancer.

    Tsujino K, Kurata T, Kawaguchi T, Kubo A, Takada M, Ando M

    Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer   9 ( 1 )   e7 - 8   2014.01( ISSN:1556-0864

  • Randomized phase III trial of erlotinib versus docetaxel as second- or third-line therapy in patients with advanced non-small cell lung cancer: Docetaxel and Erlotinib Lung cancer TriAl (DELTA).

    Tomoya Kawaguchi, Masahiko Ando, Kazuhiro Asami, et al.

    32   1902 - 1908   2014

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  • 長山ら"治療方針決定にEBUS-TBNAが有用であったサルコイドーシス合併肺腺癌の1例" Reviewed

    川口 知哉

    特定非営利活動法人 日本呼吸器内視鏡学会 気管支学   36 ( 3 )   226 - 227   2014

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    DOI: 10.18907/jjsre.36.3_226

    CiNii Article

  • The Diagnosis and Treatment of Lung Cancer Reviewed

    Hirata Kazuto, Takayama Koichi, Kawaguchi Tomoya, Sawa Kenji, Ohsaki Yoshinobu

    The Japanese Society of Internal Medicine, Nihon Naika Gakkai Kaishi   103 ( 6 )   1360 - 1374   2014( ISSN:0021-5384

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    DOI: 10.2169/naika.103.1360

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  • Will the Requirement by the US FDA to Simultaneously Co-Develop Companion Diagnostics (CDx) Delay the Approval of Receptor Tyrosine Kinase Inhibitors for RTK-Rearranged (ROS1-, RET-, AXL-, PDGFR-α-, NTRK1-) Non-Small Cell Lung Cancer Globally? Reviewed

    Ou SH, Soo RA, Kubo A, Kawaguchi T, Ahn MJ

    Frontiers in oncology   4   58   2014

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    DOI: 10.3389/fonc.2014.00058

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  • Long-term complete response in a patient with disseminated pulmonary pleomorphic carcinoma induced by cisplatin and gemcitabine. Reviewed

    Tamiya A, Asami K, Shimizu S, Matsumura A, Isa S, Okishio K, Kitaichi M, Atagi S, Takada M, Kawaguchi T, Kubo A

    Internal medicine (Tokyo, Japan)   53 ( 22 )   2625 - 8   2014( ISSN:0918-2918

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  • 長山ら"治療方針決定にEBUS-TBNAが有用であったサルコイドーシス合併肺腺癌の1例"

    川口 知哉

    気管支学   36 ( 3 )   226 - 227   2014( ISSN:02872137 ( eISSN:21860149

  • Will the Requirement by the US FDA to Simultaneously Co-Develop Companion Diagnostics (CDx) Delay the Approval of Receptor Tyrosine Kinase Inhibitors for RTK-Rearranged (ROS1-, RET-, AXL-, PDGFR-α-, NTRK1-) Non-Small Cell Lung Cancer Globally?

    Ou SH, Soo RA, Kubo A, Kawaguchi T, Ahn MJ

    Frontiers in oncology   4   58   2014

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  • Long-term complete response in a patient with disseminated pulmonary pleomorphic carcinoma induced by cisplatin and gemcitabine.

    Tamiya A, Asami K, Shimizu S, Matsumura A, Isa S, Okishio K, Kitaichi M, Atagi S, Takada M, Kawaguchi T, Kubo A

    Internal medicine (Tokyo, Japan)   53 ( 22 )   2625 - 8   2014( ISSN:0918-2918

  • Personalized maintenance therapy in advanced non-small cell lung cancer. Reviewed

    Asami K, Okishio K, Kawaguchi T, Atagi S

    Translational lung cancer research   2 ( 6 )   452 - 6   2013.12( ISSN:2218-6751

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    DOI: 10.3978/j.issn.2218-6751.2013.10.16

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  • Personalized maintenance therapy in advanced non-small cell lung cancer.

    Asami K, Okishio K, Kawaguchi T, Atagi S

    Translational lung cancer research   2 ( 6 )   452 - 6   2013.12( ISSN:2218-6751

  • DOES PRESENCE OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD) INFLUENCE CLINICAL BEHAVIOR IN PATIENTS WITH EARLY STAGE NON-SMALL CELL LUNG CANCER (ES-NSCLC)? Reviewed

    Yamamoto Satomi, Tamura Taro, Matsumura Akihide, Atagi Shinji, Kitaichi Masanori, Kawaguchi Tomoya, Hirata Kazuto

    JOURNAL OF THORACIC ONCOLOGY   8   S921 - S922   2013.11( ISSN:1556-0864

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  • Rationale and design of the Japan molecular epidemiology for lung cancer study. Reviewed

    Kawaguchi T, Ando M, Ito N, Isa S, Tamiya A, Shimizu S, Saka H, Kubo A, Koh Y, Matsumura A

    Clinical lung cancer   14 ( 5 )   596 - 600   2013.09( ISSN:1525-7304

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    DOI: 10.1016/j.cllc.2013.03.001

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  • Is consolidation chemotherapy after concurrent chemo-radiotherapy beneficial for patients with locally advanced non-small-cell lung cancer? A pooled analysis of the literature. Reviewed

    Tsujino K, Kurata T, Yamamoto S, Kawaguchi T, Kubo A, Isa S, Hasegawa Y, Ou SH, Takada M, Ando M

    Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer   8 ( 9 )   1181 - 9   2013.09( ISSN:1556-0864

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    DOI: 10.1097/JTO.0b013e3182988348

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  • Rationale and design of the Japan molecular epidemiology for lung cancer study.

    Kawaguchi T, Ando M, Ito N, Isa S, Tamiya A, Shimizu S, Saka H, Kubo A, Koh Y, Matsumura A

    Clinical lung cancer   14 ( 5 )   596 - 600   2013.09( ISSN:1525-7304

  • Is consolidation chemotherapy after concurrent chemo-radiotherapy beneficial for patients with locally advanced non-small-cell lung cancer? A pooled analysis of the literature.

    Tsujino K, Kurata T, Yamamoto S, Kawaguchi T, Kubo A, Isa S, Hasegawa Y, Ou SH, Takada M, Ando M

    Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer   8 ( 9 )   1181 - 9   2013.09( ISSN:1556-0864

  • 気管支内過誤腫により気管支拡張をきたし肺癌と鑑別を要した腫瘤影を呈した1例 Reviewed

    廣岡 亜矢, 田宮 朗裕, 杉本 親寿, 橘 和延, 川口 知哉

    (NPO)日本呼吸器内視鏡学会 気管支学   35 ( 4 )   376 - 380   2013.07( ISSN:0287-2137

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    背景.羽過誤腫は肺実質内と気管支内に発症するが、後者は比較的稀である。今回我々は気管支内過誤腫によりその末梢側が気管支拡張をきたし腫瘤影を呈した1例を経験したので、報告する。症例.54歳。男性。健診で胸部X線異常陰影を指摘された。胸部CT上、右下葉に巨大腫瘤影を認め、気管支鏡検査では、右B8に表面平滑な腫瘤として認められ、入口部を完全閉塞していた。同部の生検では、癌組織を認めないものの確定診断に至らなかった。PET-CTにて高度集積を伴う巨大腫瘤影のため悪性腫瘍を強く疑い、気管支鏡下で末梢側を確認できず内視鏡的切除は困難と判断したため、外科的に右下葉切除術を行った。病理診断は、右B8入口部の径15mm大の気管支内過誤腫と、その末梢の気管支拡張症および閉塞性肺炎であった。結論.右B8入口部の過誤腫とその末梢の閉塞により末梢側気管支の拡張と閉塞性肺炎を引き起こし、画像上腫瘤陰影を呈したものと考えられた。(著者抄録)

  • 気管支内過誤腫により気管支拡張をきたし肺癌と鑑別を要した腫瘤影を呈した1例

    廣岡 亜矢, 田宮 朗裕, 杉本 親寿, 橘 和延, 川口 知哉

    気管支学   35 ( 4 )   376 - 380   2013.07( ISSN:0287-2137

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    背景.羽過誤腫は肺実質内と気管支内に発症するが、後者は比較的稀である。今回我々は気管支内過誤腫によりその末梢側が気管支拡張をきたし腫瘤影を呈した1例を経験したので、報告する。症例.54歳。男性。健診で胸部X線異常陰影を指摘された。胸部CT上、右下葉に巨大腫瘤影を認め、気管支鏡検査では、右B8に表面平滑な腫瘤として認められ、入口部を完全閉塞していた。同部の生検では、癌組織を認めないものの確定診断に至らなかった。PET-CTにて高度集積を伴う巨大腫瘤影のため悪性腫瘍を強く疑い、気管支鏡下で末梢側を確認できず内視鏡的切除は困難と判断したため、外科的に右下葉切除術を行った。病理診断は、右B8入口部の径15mm大の気管支内過誤腫と、その末梢の気管支拡張症および閉塞性肺炎であった。結論.右B8入口部の過誤腫とその末梢の閉塞により末梢側気管支の拡張と閉塞性肺炎を引き起こし、画像上腫瘤陰影を呈したものと考えられた。(著者抄録)

  • Does presence of chronic obstructive pulmonary disease (COPD) influence clinical behavior in patients with early-stage non-small cell lung cancer (ESNSCLC)? Reviewed

    Yamamoto Satomi, Kawaguchi Tomoya, Tamura Taro, Asami Kazuhiro, Okishio Kyoichi, Atagi Shinji, Yoon Hyungeun, Matsumura Akihide, Shimizu Shigeki, Kitaichi Masanori, Takada Minoru, Hirata Kazuto

    JOURNAL OF CLINICAL ONCOLOGY   31 ( 15 )   2013.05( ISSN:0732-183X

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  • Phase II study of triplet chemotherapy using Tegafur-Uracil, Vinorelbine, Gemcitabine for advanced non-small cell lung cancer. Reviewed

    Minomo S, Asami K, Okishio K, Kawaguchi T, Fujita Y, Takata S, Tamura A, Saitou R, Atagi S

    Anticancer research   33 ( 3 )   1163 - 7   2013.03( ISSN:0250-7005

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    PubMed

  • Continued treatment with gefitinib beyond progressive disease benefits patients with activating EGFR mutations. Reviewed

    Asami K, Okuma T, Hirashima T, Kawahara M, Atagi S, Kawaguchi T, Okishio K, Omachi N, Takeuchi N

    Lung cancer (Amsterdam, Netherlands)   79 ( 3 )   276 - 82   2013.03( ISSN:0169-5002

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    DOI: 10.1016/j.lungcan.2012.11.022

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  • Continued treatment with gefitinib beyond progressive disease benefits patients with activating EGFR mutations.

    Asami K, Okuma T, Hirashima T, Kawahara M, Atagi S, Kawaguchi T, Okishio K, Omachi N, Takeuchi N

    Lung cancer (Amsterdam, Netherlands)   79 ( 3 )   276 - 82   2013.03( ISSN:0169-5002

  • Phase II study of triplet chemotherapy using Tegafur-Uracil, Vinorelbine, Gemcitabine for advanced non-small cell lung cancer.

    Minomo S, Asami K, Okishio K, Kawaguchi T, Fujita Y, Takata S, Tamura A, Saitou R, Atagi S

    Anticancer research   33 ( 3 )   1163 - 7   2013.03( ISSN:0250-7005

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  • Development of non-small-cell lung cancer in a father and his son who never smoked. Reviewed

    Kurahara Y, Utsumi T, Kawaguchi T

    Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer   8 ( 2 )   e13 - 4   2013.02( ISSN:1556-0864

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1097/JTO.0b013e318279e97a

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  • Development of non-small-cell lung cancer in a father and his son who never smoked.

    Kurahara Y, Utsumi T, Kawaguchi T

    Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer   8 ( 2 )   e13 - 4   2013.02( ISSN:1556-0864

  • Prospective Assessment of Continuation of Erlotinib or Gefitinib in Patients with Acquired Resistance to Erlotinib or Gefitinib Followed by the Addition of Pemetrexed Reviewed

    Yoshimura Naruo, Okishio Kyoichi, Mitsuoka Shigeki, Kimura Tatsuo, Kawaguchi Tomoya, Kobayashi Masaji, Hirashima Tomonori, Daga Haruko, Takeda Koji, Hirata Kazuto, Kudoh Shinzoh

    JOURNAL OF THORACIC ONCOLOGY   8 ( 1 )   96 - 101   2013.01( ISSN:1556-0864

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    DOI: 10.1097/JTO.0b013e3182762bfb

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  • Prospective assessment of continuation of erlotinib or gefitinib in patients with acquired resistance to erlotinib or gefitinib followed by the addition of pemetrexed.

    Yoshimura N, Okishio K, Mitsuoka S, Kimura T, Kawaguchi T, Kobayashi M, Hirashima T, Daga H, Takeda K, Hirata K, Kudoh S

    Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer   8 ( 1 )   96 - 101   2013.01( ISSN:1556-0864

  • Phase2 study of bevacizumab with carboplatin-paclitaxel for non-small cell lung cancer with malignant pleural effusion. Reviewed

    Tamiya M, Tamiya A, Yamadori T, Nakao K, Asami K, Yasue T, Otsuka T, Shiroyama T, Morishita N, Suzuki H, Okamoto N, Okishio K, Kawaguchi T, Atagi S, Kawase I, Hirashima T

    Medical oncology (Northwood, London, England)   30 ( 3 )   676   2013( ISSN:1357-0560

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s12032-013-0676-7

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  • Cardiac tamponade with community-acquired methicillin-resistant Staphylococcus aureus pericarditis. Reviewed

    Kurahara Y, Kawaguchi T

    Internal medicine (Tokyo, Japan)   52 ( 15 )   1753   2013( ISSN:0918-2918

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    PubMed

  • Cardiac tamponade with community-acquired methicillin-resistant Staphylococcus aureus pericarditis.

    Kurahara Y, Kawaguchi T

    Internal medicine (Tokyo, Japan)   52 ( 15 )   1753   2013( ISSN:0918-2918

  • Phase2 study of bevacizumab with carboplatin-paclitaxel for non-small cell lung cancer with malignant pleural effusion.

    Tamiya M, Tamiya A, Yamadori T, Nakao K, Asami K, Yasue T, Otsuka T, Shiroyama T, Morishita N, Suzuki H, Okamoto N, Okishio K, Kawaguchi T, Atagi S, Kawase I, Hirashima T

    Medical oncology (Northwood, London, England)   30 ( 3 )   676   2013( ISSN:1357-0560

  • Polymorphisms in intron 1 of the EGFR gene in non-small cell lung cancer patients. Reviewed

    Shitara M, Sasaki H, Yokota K, Okuda K, Hikosaka Y, Moriyama S, Yano M, Kawaguchi T, Kubo A, Takada M, Kitahara N, Okumura M, Matsumura A, Iuchi K, Fujii Y

    Experimental and therapeutic medicine   4 ( 5 )   785 - 789   2012.11( ISSN:1792-0981

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.3892/etm.2012.681

    PubMed

  • Chemotherapy is beneficial for elderly patients with advanced non-small-cell lung cancer: analysis of patients aged 70-74, 75-79, and 80 or older in Japan. Reviewed

    Kawaguchi T, Tamiya A, Tamura A, Arao M, Saito R, Matsumura A, Ou SH, Tamura T

    Clinical lung cancer   13 ( 6 )   442 - 7   2012.11( ISSN:1525-7304

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.cllc.2012.03.010

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  • Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors Beyond Progressive Disease A Retrospective Analysis for Japanese Patients with Activating EGFR Mutations Reviewed

    Nishie Kenichi, Kawaguchi Tomoya, Tamiya Akihiro, Mimori Tomoyasu, Takeuchi Naoko, Matsuda Yoshinobu, Omachi Naoki, Asami Kazuhiro, Okishio Kyoichi, Atagi Shinji, Okuma Tomohisa, Kubo Akihito, Maruyama Yoshihito, Kudoh Shinzoh, Takada Minoru

    JOURNAL OF THORACIC ONCOLOGY   7 ( 11 )   1722 - 1727   2012.11( ISSN:1556-0864

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1097/JTO.0b013e31826913f7

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  • Chemotherapy is beneficial for elderly patients with advanced non-small-cell lung cancer: analysis of patients aged 70-74, 75-79, and 80 or older in Japan.

    Kawaguchi T, Tamiya A, Tamura A, Arao M, Saito R, Matsumura A, Ou SH, Tamura T

    Clinical lung cancer   13 ( 6 )   442 - 7   2012.11( ISSN:1525-7304

  • Epidermal growth factor receptor tyrosine kinase inhibitors beyond progressive disease: a retrospective analysis for Japanese patients with activating EGFR mutations.

    Nishie K, Kawaguchi T, Tamiya A, Mimori T, Takeuchi N, Matsuda Y, Omachi N, Asami K, Okishio K, Atagi S, Okuma T, Kubo A, Maruyama Y, Kudoh S, Takada M

    Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer   7 ( 11 )   1722 - 7   2012.11( ISSN:1556-0864

  • Polymorphisms in intron 1 of the EGFR gene in non-small cell lung cancer patients.

    Shitara M, Sasaki H, Yokota K, Okuda K, Hikosaka Y, Moriyama S, Yano M, Kawaguchi T, Kubo A, Takada M, Kitahara N, Okumura M, Matsumura A, Iuchi K, Fujii Y

    Experimental and therapeutic medicine   4 ( 5 )   785 - 789   2012.11( ISSN:1792-0981

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  • EPIDERMAL GROWTH FACTOR RECEPTOR (EGFR) TYROSINE KINASE INHIBITORS BEYOND PROGRESSIVE DISEASE: A RETROSPECTIVE ANALYSIS FOR JAPANESE PATIENTS WITH ACTIVATING EGFR MUTATIONS Reviewed

    Omachi N., Kawaguchi T., Tamiya A., Mimori T., Takeuchi N., Matsuda Y., Asami K., Okishio K., Atagi S., Okuma T., Kubo A., Maruyama Y., Kudoh S., Takada M., Nishie K.

    ANNALS OF ONCOLOGY   23   117 - 117   2012.10( ISSN:0923-7534

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  • Efficacy of carboplatin and paclitaxel with bevacizumab as salvage chemotherapy for non-small cell lung cancer after failure of platinum-doublet chemotherapy. Reviewed

    Tamiya M, Tamiya A, Nakao K, Asami K, Okishio K, Satomu M, Shiroyama T, Morishita N, Suzuki H, Sasada S, Okamoto N, Okishio K, Kawaguchi T, Kobayashi M, Atagi S, Hirashima T, Kawase I

    Anticancer research   32 ( 8 )   3553 - 7   2012.08( ISSN:0250-7005

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    PubMed

  • Efficacy of carboplatin and paclitaxel with bevacizumab as salvage chemotherapy for non-small cell lung cancer after failure of platinum-doublet chemotherapy.

    Tamiya M, Tamiya A, Nakao K, Asami K, Okishio K, Satomu M, Shiroyama T, Morishita N, Suzuki H, Sasada S, Okamoto N, Okishio K, Kawaguchi T, Kobayashi M, Atagi S, Hirashima T, Kawase I

    Anticancer research   32 ( 8 )   3553 - 7   2012.08( ISSN:0250-7005

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  • A phase I/II study of carboplatin plus gemcitabine for elderly patients with advanced non-small cell lung cancer: West Japan Thoracic Oncology Group Trial (WJTOG) 2905. Reviewed

    Kurata T, Hirashima T, Iwamoto Y, Kawaguchi T, Ikeda N, Tsuboi M, Sawa T, Ishiguro T, Aoki T, Kotani Y, Nakagawa K, Fukuoka M

    Lung cancer (Amsterdam, Netherlands)   77 ( 1 )   110 - 5   2012.07( ISSN:0169-5002

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.lungcan.2011.12.016

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  • A phase I/II study of carboplatin plus gemcitabine for elderly patients with advanced non-small cell lung cancer: West Japan Thoracic Oncology Group Trial (WJTOG) 2905.

    Kurata T, Hirashima T, Iwamoto Y, Kawaguchi T, Ikeda N, Tsuboi M, Sawa T, Ishiguro T, Aoki T, Kotani Y, Nakagawa K, Fukuoka M

    Lung cancer (Amsterdam, Netherlands)   77 ( 1 )   110 - 5   2012.07( ISSN:0169-5002

  • Differences in outcome and toxicity between Asian and caucasian patients with lung cancer treated with systemic therapy. Reviewed

    Soo RA, Kawaguchi T, Loh M, Ou SH, Shieh MP, Cho BC, Mok TS, Soong R

    Future oncology (London, England)   8 ( 4 )   451 - 62   2012.04( ISSN:1479-6694

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.2217/fon.12.25

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  • Differences in outcome and toxicity between Asian and caucasian patients with lung cancer treated with systemic therapy.

    Soo RA, Kawaguchi T, Loh M, Ou SH, Shieh MP, Cho BC, Mok TS, Soong R

    Future oncology (London, England)   8 ( 4 )   451 - 62   2012.04( ISSN:1479-6694

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  • A multi-institutional phase II trial of consolidation S-1 after concurrent chemoradiotherapy with cisplatin and vinorelbine for locally advanced non-small cell lung cancer. Reviewed

    Kawaguchi T, Takada M, Ando M, Okishio K, Atagi S, Fujita Y, Tomizawa Y, Hayashihara K, Okano Y, Takahashi F, Saito R, Matsumura A, Tamura A

    European journal of cancer (Oxford, England : 1990)   48 ( 5 )   672 - 7   2012.03( ISSN:0959-8049

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    DOI: 10.1016/j.ejca.2011.11.020

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  • A multi-institutional phase II trial of consolidation S-1 after concurrent chemoradiotherapy with cisplatin and vinorelbine for locally advanced non-small cell lung cancer.

    Kawaguchi T, Takada M, Ando M, Okishio K, Atagi S, Fujita Y, Tomizawa Y, Hayashihara K, Okano Y, Takahashi F, Saito R, Matsumura A, Tamura A

    European journal of cancer (Oxford, England : 1990)   48 ( 5 )   672 - 7   2012.03( ISSN:0959-8049

  • Low Wilms' tumor gene expression in tumor tissues predicts poor prognosis in patients with non-small-cell lung cancer. Reviewed

    Hayashi S, Oji Y, Kanai Y, Teramoto T, Kitaichi M, Kawaguchi T, Okada M, Sugiyama H, Matsumura A

    Cancer investigation   30 ( 2 )   165 - 71   2012.02( ISSN:0735-7907

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.3109/07357907.2011.633291

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  • Low Wilms' tumor gene expression in tumor tissues predicts poor prognosis in patients with non-small-cell lung cancer.

    Hayashi S, Oji Y, Kanai Y, Teramoto T, Kitaichi M, Kawaguchi T, Okada M, Sugiyama H, Matsumura A

    Cancer investigation   30 ( 2 )   165 - 71   2012.02( ISSN:0735-7907

  • Small-cell lung cancer in never-smokers: a case series with information on family history of cancer and environmental tobacco smoke. Reviewed

    Kurahara Y, Kawaguchi T, Tachibana K, Atagi S, Hayashi S, Kitaichi M, Ou SH, Takada M

    Clinical lung cancer   13 ( 1 )   75 - 9   2012.01( ISSN:1525-7304

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.cllc.2011.04.001

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  • Small-cell lung cancer in never-smokers: a case series with information on family history of cancer and environmental tobacco smoke.

    Kurahara Y, Kawaguchi T, Tachibana K, Atagi S, Hayashi S, Kitaichi M, Ou SH, Takada M

    Clinical lung cancer   13 ( 1 )   75 - 9   2012.01( ISSN:1525-7304

  • Ethnic difference in hematological toxicity in patients with non-small cell lung cancer treated with chemotherapy: a pooled analysis on Asian versus non-Asian in phase II and III clinical trials. Reviewed

    Hasegawa Y, Kawaguchi T, Kubo A, Ando M, Shiraishi J, Isa S, Tsuji T, Tsujino K, Ou SH, Nakagawa K, Takada M

    Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer   6 ( 11 )   1881 - 8   2011.11( ISSN:1556-0864

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1097/JTO.0b013e31822722b6

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  • Ethnic difference in hematological toxicity in patients with non-small cell lung cancer treated with chemotherapy: a pooled analysis on Asian versus non-Asian in phase II and III clinical trials.

    Hasegawa Y, Kawaguchi T, Kubo A, Ando M, Shiraishi J, Isa S, Tsuji T, Tsujino K, Ou SH, Nakagawa K, Takada M

    Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer   6 ( 11 )   1881 - 8   2011.11( ISSN:1556-0864

  • Rare subtypes of adenocarcinoma of the lung. Reviewed

    Ou SH, Kawaguchi T, Soo RA, Kitaichi M

    Expert review of anticancer therapy   11 ( 10 )   1535 - 42   2011.10( ISSN:1473-7140

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1586/era.11.99

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  • Rare subtypes of adenocarcinoma of the lung.

    Ou SH, Kawaguchi T, Soo RA, Kitaichi M

    Expert review of anticancer therapy   11 ( 10 )   1535 - 42   2011.10( ISSN:1473-7140

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  • Prospective Assesment of Combined Pemetrexed and Erlotinib or Gefitinib Therapy After the Relapse to Erlotinib or Gefitinib in Patients With Advanced Non-Small Cell Lung Cancer Having an Active Epidermal Growth Factor Receptor Mutation Reviewed

    Okishio K., Yoshimura N., Kimura T., Daga H., Takeda K., Kawaguchi T., Kobayashi M., Hirashima T., Hirata K., Kudoh S.

    EUROPEAN JOURNAL OF CANCER   47   S628 - S629   2011.09( ISSN:0959-8049

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  • Duration of prior gefitinib treatment predicts survival potential in patients with lung adenocarcinoma receiving subsequent erlotinib. Reviewed

    Asami K, Kawahara M, Atagi S, Kawaguchi T, Okishio K

    Lung cancer (Amsterdam, Netherlands)   73 ( 2 )   211 - 6   2011.08( ISSN:0169-5002

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.lungcan.2010.12.014

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  • Duration of prior gefitinib treatment predicts survival potential in patients with lung adenocarcinoma receiving subsequent erlotinib.

    Asami K, Kawahara M, Atagi S, Kawaguchi T, Okishio K

    Lung cancer (Amsterdam, Netherlands)   73 ( 2 )   211 - 6   2011.08( ISSN:0169-5002

  • ゲフィチニブにより治療された肺腺癌由来悪性胸水(Malignant Pleural Effusion from Lung Adenocarcinoma Treated by Gefitinib) Reviewed

    Kubo Akihito, Koh Yasuhiro, Kawaguchi Tomoya, Isa Shun-ichi, Okamoto Isamu, Fukuoka Junya, Kusunoki Yoko, Kitaichi Masanori, Takada Minoru, Nakagawa Kazuhiko

    (一社)日本内科学会 Internal Medicine   50 ( 7 )   745 - 748   2011.04( ISSN:0918-2918

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    上皮増殖因子受容体を標的とする低分子阻害剤は非小細胞肺癌に有効であることが知られているが、悪性胸水(MPE)に対する薬力学は不明のままである。大量のMPEを伴う肺腺癌患者(67歳男性)をゲフィチニブと胸部ドレナージにより治療することができた。ゲフィチニブ治療の前および治療中に得た逐次MPEサンプルを用いて、癌細胞の形態学的変化とアポトーシスを調べた。その結果、癌細胞のアポトーシスはゲフィチニブ治療早期の4時間で検出されたが、治療前には認められなかった。以上より、このような分子標的薬の薬力学的評価は、MPEに対して実行可能であることが示唆された。

  • ゲフィチニブにより治療された肺腺癌由来悪性胸水(Malignant Pleural Effusion from Lung Adenocarcinoma Treated by Gefitinib)

    Kubo Akihito, Koh Yasuhiro, Kawaguchi Tomoya, Isa Shun-ichi, Okamoto Isamu, Fukuoka Junya, Kusunoki Yoko, Kitaichi Masanori, Takada Minoru, Nakagawa Kazuhiko

    Internal Medicine   50 ( 7 )   745 - 748   2011.04( ISSN:0918-2918

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    上皮増殖因子受容体を標的とする低分子阻害剤は非小細胞肺癌に有効であることが知られているが、悪性胸水(MPE)に対する薬力学は不明のままである。大量のMPEを伴う肺腺癌患者(67歳男性)をゲフィチニブと胸部ドレナージにより治療することができた。ゲフィチニブ治療の前および治療中に得た逐次MPEサンプルを用いて、癌細胞の形態学的変化とアポトーシスを調べた。その結果、癌細胞のアポトーシスはゲフィチニブ治療早期の4時間で検出されたが、治療前には認められなかった。以上より、このような分子標的薬の薬力学的評価は、MPEに対して実行可能であることが示唆された。

  • Long exposure of environmental tobacco smoke associated with activating EGFR mutations in never-smokers with non-small cell lung cancer. Reviewed

    Kawaguchi T, Ando M, Kubo A, Takada M, Atagi S, Okishio K, Asami K, Matsumura A, Tsujino K, Ignatius OS, Sasaki H

    Clinical cancer research : an official journal of the American Association for Cancer Research   17 ( 1 )   39 - 45   2011.01( ISSN:1078-0432

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1158/1078-0432.CCR-10-1773

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  • Long exposure of environmental tobacco smoke associated with activating EGFR mutations in never-smokers with non-small cell lung cancer.

    Kawaguchi T, Ando M, Kubo A, Takada M, Atagi S, Okishio K, Asami K, Matsumura A, Tsujino K, Ignatius OS, Sasaki H

    Clinical cancer research : an official journal of the American Association for Cancer Research   17 ( 1 )   39 - 45   2011.01( ISSN:1078-0432

  • Malignant pleural effusion from lung adenocarcinoma treated by gefitinib. Reviewed

    Kubo A, Koh Y, Kawaguchi T, Isa S, Okamoto I, Fukuoka J, Kusunoki Y, Kitaichi M, Takada M, Nakagawa K

    Internal medicine (Tokyo, Japan)   50 ( 7 )   745 - 8   2011( ISSN:0918-2918

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    PubMed

  • Malignant pleural effusion from lung adenocarcinoma treated by gefitinib.

    Kubo A, Koh Y, Kawaguchi T, Isa S, Okamoto I, Fukuoka J, Kusunoki Y, Kitaichi M, Takada M, Nakagawa K

    Internal medicine (Tokyo, Japan)   50 ( 7 )   745 - 8   2011( ISSN:0918-2918

  • Japanese ethnicity compared with Caucasian ethnicity and never-smoking status are independent favorable prognostic factors for overall survival in non-small cell lung cancer: a collaborative epidemiologic study of the National Hospital Organization Study Group for Lung Cancer (NHSGLC) in Japan and a Southern California Regional Cancer Registry databases. Reviewed

    Kawaguchi T, Matsumura A, Fukai S, Tamura A, Saito R, Zell JA, Maruyama Y, Ziogas A, Kawahara M, Ignatius Ou SH

    Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer   5 ( 7 )   1001 - 10   2010.07( ISSN:1556-0864

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1097/JTO.0b013e3181e2f607

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  • Gender, histology, and time of diagnosis are important factors for prognosis: analysis of 1499 never-smokers with advanced non-small cell lung cancer in Japan. Reviewed

    Kawaguchi T, Takada M, Kubo A, Matsumura A, Fukai S, Tamura A, Saito R, Kawahara M, Maruyama Y

    Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer   5 ( 7 )   1011 - 7   2010.07( ISSN:1556-0864

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1097/JTO.0b013e3181dc213e

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  • Gender, histology, and time of diagnosis are important factors for prognosis: analysis of 1499 never-smokers with advanced non-small cell lung cancer in Japan.

    Kawaguchi T, Takada M, Kubo A, Matsumura A, Fukai S, Tamura A, Saito R, Kawahara M, Maruyama Y

    Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer   5 ( 7 )   1011 - 7   2010.07( ISSN:1556-0864

  • Japanese ethnicity compared with Caucasian ethnicity and never-smoking status are independent favorable prognostic factors for overall survival in non-small cell lung cancer: a collaborative epidemiologic study of the National Hospital Organization Study Group for Lung Cancer (NHSGLC) in Japan and a Southern California Regional Cancer Registry databases.

    Kawaguchi T, Matsumura A, Fukai S, Tamura A, Saito R, Zell JA, Maruyama Y, Ziogas A, Kawahara M, Ignatius Ou SH

    Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer   5 ( 7 )   1001 - 10   2010.07( ISSN:1556-0864

  • Performance status and smoking status are independent favorable prognostic factors for survival in non-small cell lung cancer: a comprehensive analysis of 26,957 patients with NSCLC. Reviewed

    Kawaguchi T, Takada M, Kubo A, Matsumura A, Fukai S, Tamura A, Saito R, Maruyama Y, Kawahara M, Ignatius Ou SH

    Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer   5 ( 5 )   620 - 30   2010.05( ISSN:1556-0864

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1097/JTO.0b013e3181d2dcd9

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  • Performance status and smoking status are independent favorable prognostic factors for survival in non-small cell lung cancer: a comprehensive analysis of 26,957 patients with NSCLC.

    Kawaguchi T, Takada M, Kubo A, Matsumura A, Fukai S, Tamura A, Saito R, Maruyama Y, Kawahara M, Ignatius Ou SH

    Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer   5 ( 5 )   620 - 30   2010.05( ISSN:1556-0864

  • A feasibility and efficacy study on bronchoscopy with a virtual navigation system. Reviewed

    Omiya H, Kikuyama A, Kubo A, Okishio K, Kawaguchi T, Atagi S, Kawahara M, Takada M, Kusunoki Y

    Journal of bronchology & interventional pulmonology   17 ( 1 )   11 - 8   2010.01( ISSN:1944-6586

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1097/LBR.0b013e3181cc3c86

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  • A feasibility and efficacy study on bronchoscopy with a virtual navigation system.

    Omiya H, Kikuyama A, Kubo A, Okishio K, Kawaguchi T, Atagi S, Kawahara M, Takada M, Kusunoki Y

    Journal of bronchology & interventional pulmonology   17 ( 1 )   11 - 8   2010.01( ISSN:1944-6586

  • Serum osteopontin levels are highly prognostic for survival in advanced non-small cell lung cancer: results from JMTO LC 0004. Reviewed

    Isa S, Kawaguchi T, Teramukai S, Minato K, Ohsaki Y, Shibata K, Yonei T, Hayashibara K, Fukushima M, Kawahara M, Furuse K, Mack PC

    Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer   4 ( 9 )   1104 - 10   2009.09( ISSN:1556-0864

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1097/JTO.0b013e3181ae2844

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  • Serum osteopontin levels are highly prognostic for survival in advanced non-small cell lung cancer: results from JMTO LC 0004.

    Isa S, Kawaguchi T, Teramukai S, Minato K, Ohsaki Y, Shibata K, Yonei T, Hayashibara K, Fukushima M, Kawahara M, Furuse K, Mack PC

    Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer   4 ( 9 )   1104 - 10   2009.09( ISSN:1556-0864

  • Response rate is associated with prolonged survival in patients with advanced non-small cell lung cancer treated with gefitinib or erlotinib. Reviewed

    Tsujino K, Kawaguchi T, Kubo A, Aono N, Nakao K, Koh Y, Tachibana K, Isa S, Takada M, Kurata T

    Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer   4 ( 8 )   994 - 1001   2009.08( ISSN:1556-0864

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1097/JTO.0b013e3181a94a2f

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  • Response rate is associated with prolonged survival in patients with advanced non-small cell lung cancer treated with gefitinib or erlotinib.

    Tsujino K, Kawaguchi T, Kubo A, Aono N, Nakao K, Koh Y, Tachibana K, Isa S, Takada M, Kurata T

    Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer   4 ( 8 )   994 - 1001   2009.08( ISSN:1556-0864

  • Japanese-US common-arm analysis of paclitaxel plus carboplatin in advanced non-small-cell lung cancer: a model for assessing population-related pharmacogenomics. Reviewed

    Gandara DR, Kawaguchi T, Crowley J, Moon J, Furuse K, Kawahara M, Teramukai S, Ohe Y, Kubota K, Williamson SK, Gautschi O, Lenz HJ, McLeod HL, Lara PN Jr, Coltman CA Jr, Fukuoka M, Saijo N, Fukushima M, Mack PC

    Journal of clinical oncology : official journal of the American Society of Clinical Oncology   27 ( 21 )   3540 - 6   2009.07( ISSN:0732-183X

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1200/JCO.2008.20.8793

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  • Japanese-US common-arm analysis of paclitaxel plus carboplatin in advanced non-small-cell lung cancer: a model for assessing population-related pharmacogenomics.

    Gandara DR, Kawaguchi T, Crowley J, Moon J, Furuse K, Kawahara M, Teramukai S, Ohe Y, Kubota K, Williamson SK, Gautschi O, Lenz HJ, McLeod HL, Lara PN Jr, Coltman CA Jr, Fukuoka M, Saijo N, Fukushima M, Mack PC

    Journal of clinical oncology : official journal of the American Society of Clinical Oncology   27 ( 21 )   3540 - 6   2009.07( ISSN:0732-183X

  • EGFR R497K polymorphism is a favorable prognostic factor for advanced lung cancer. Reviewed

    Sasaki H, Okuda K, Shimizu S, Takada M, Kawahara M, Kitahara N, Okumura M, Matsumura A, Iuchi K, Kawaguchi T, Kubo A, Kawano O, Yukiue H, Yano M, Fujii Y

    Journal of cancer research and clinical oncology   135 ( 2 )   313 - 8   2009.02( ISSN:0171-5216

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00432-008-0464-5

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  • EGFR R497K polymorphism is a favorable prognostic factor for advanced lung cancer.

    Sasaki H, Okuda K, Shimizu S, Takada M, Kawahara M, Kitahara N, Okumura M, Matsumura A, Iuchi K, Kawaguchi T, Kubo A, Kawano O, Yukiue H, Yano M, Fujii Y

    Journal of cancer research and clinical oncology   135 ( 2 )   313 - 8   2009.02( ISSN:0171-5216

  • A novel EGFR mutation D1012H and polymorphism at exon 25 in Japanese lung cancer. Reviewed

    Sasaki H, Okuda K, Takada M, Kawahara M, Kitahara N, Matsumura A, Iuchi K, Kawaguchi T, Kubo A, Endo K, Kawano O, Yukiue H, Yano M, Fujii Y

    Journal of cancer research and clinical oncology   134 ( 12 )   1371 - 6   2008.12( ISSN:0171-5216

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00432-008-0411-5

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  • A novel EGFR mutation D1012H and polymorphism at exon 25 in Japanese lung cancer.

    Sasaki H, Okuda K, Takada M, Kawahara M, Kitahara N, Matsumura A, Iuchi K, Kawaguchi T, Kubo A, Endo K, Kawano O, Yukiue H, Yano M, Fujii Y

    Journal of cancer research and clinical oncology   134 ( 12 )   1371 - 6   2008.12( ISSN:0171-5216

  • Phase I/II study of docetaxel and S-1 in patients with previously treated non-small cell lung cancer. Reviewed

    Atagi S, Kawahara M, Kusunoki Y, Takada M, Kawaguchi T, Okishio K, Kubo A, Uehira K, Yumine K, Tomizawa Y, Saito R, Fukai S, Komatsu H

    Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer   3 ( 9 )   1012 - 7   2008.09( ISSN:1556-0864

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1097/JTO.0b013e318183f8ed

    PubMed

  • Phase I/II study of docetaxel and S-1 in patients with previously treated non-small cell lung cancer.

    Atagi S, Kawahara M, Kusunoki Y, Takada M, Kawaguchi T, Okishio K, Kubo A, Uehira K, Yumine K, Tomizawa Y, Saito R, Fukai S, Komatsu H

    Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer   3 ( 9 )   1012 - 7   2008.09( ISSN:1556-0864

  • EGFR polymorphism of the kinase domain in Japanese lung cancer. Reviewed

    Sasaki H, Endo K, Takada M, Kawahara M, Tanaka H, Kitahara N, Matsumura A, Iuchi K, Kawaguchi T, Okuda K, Kawano O, Yukiue H, Yokoyama T, Yano M, Fujii Y

    The Journal of surgical research   148 ( 2 )   260 - 3   2008.08( ISSN:0022-4804

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.jss.2007.09.001

    PubMed

  • EGFR polymorphism of the kinase domain in Japanese lung cancer.

    Sasaki H, Endo K, Takada M, Kawahara M, Tanaka H, Kitahara N, Matsumura A, Iuchi K, Kawaguchi T, Okuda K, Kawano O, Yukiue H, Yokoyama T, Yano M, Fujii Y

    The Journal of surgical research   148 ( 2 )   260 - 3   2008.08( ISSN:0022-4804

  • Epidermal growth factor receptor gene amplification and gefitinib sensitivity in patients with recurrent lung cancer. Reviewed

    Sasaki H, Endo K, Okuda K, Kawano O, Kitahara N, Tanaka H, Matsumura A, Iuchi K, Takada M, Kawahara M, Kawaguchi T, Yukiue H, Yokoyama T, Yano M, Fujii Y

    Journal of cancer research and clinical oncology   134 ( 5 )   569 - 77   2008.05( ISSN:0171-5216

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00432-007-0320-z

    PubMed

  • Epidermal growth factor receptor gene amplification and gefitinib sensitivity in patients with recurrent lung cancer.

    Sasaki H, Endo K, Okuda K, Kawano O, Kitahara N, Tanaka H, Matsumura A, Iuchi K, Takada M, Kawahara M, Kawaguchi T, Yukiue H, Yokoyama T, Yano M, Fujii Y

    Journal of cancer research and clinical oncology   134 ( 5 )   569 - 77   2008.05( ISSN:0171-5216

  • EGFR exon 20 insertion mutation in Japanese lung cancer. Reviewed

    Sasaki H, Endo K, Takada M, Kawahara M, Kitahara N, Tanaka H, Okumura M, Matsumura A, Iuchi K, Kawaguchi T, Kawano O, Yukiue H, Yokoyama T, Yano M, Fujii Y

    Lung cancer (Amsterdam, Netherlands)   58 ( 3 )   324 - 8   2007.12( ISSN:0169-5002

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.lungcan.2007.06.024

    PubMed

  • EGFR exon 20 insertion mutation in Japanese lung cancer.

    Sasaki H, Endo K, Takada M, Kawahara M, Kitahara N, Tanaka H, Okumura M, Matsumura A, Iuchi K, Kawaguchi T, Kawano O, Yukiue H, Yokoyama T, Yano M, Fujii Y

    Lung cancer (Amsterdam, Netherlands)   58 ( 3 )   324 - 8   2007.12( ISSN:0169-5002

  • L858R EGFR mutation status correlated with clinico-pathological features of Japanese lung cancer. Reviewed

    Sasaki H, Endo K, Takada M, Kawahara M, Kitahara N, Tanaka H, Okumura M, Matsumura A, Iuchi K, Kawaguchi T, Yukiue H, Kobayashi Y, Yano M, Fujii Y

    Lung cancer (Amsterdam, Netherlands)   54 ( 1 )   103 - 8   2006.10( ISSN:0169-5002

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.lungcan.2006.06.003

    PubMed

  • L858R EGFR mutation status correlated with clinico-pathological features of Japanese lung cancer.

    Sasaki H, Endo K, Takada M, Kawahara M, Kitahara N, Tanaka H, Okumura M, Matsumura A, Iuchi K, Kawaguchi T, Yukiue H, Kobayashi Y, Yano M, Fujii Y

    Lung cancer (Amsterdam, Netherlands)   54 ( 1 )   103 - 8   2006.10( ISSN:0169-5002

  • Second primary cancers in patients with stage III non-small cell lung cancer successfully treated with chemo-radiotherapy. Reviewed

    Kawaguchi T, Matsumura A, Iuchi K, Ishikawa S, Maeda H, Fukai S, Komatsu H, Kawahara M

    Japanese journal of clinical oncology   36 ( 1 )   7 - 11   2006.01( ISSN:0368-2811

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/jjco/hyi208

    PubMed

  • Second primary cancers in patients with stage III non-small cell lung cancer successfully treated with chemo-radiotherapy.

    Kawaguchi T, Matsumura A, Iuchi K, Ishikawa S, Maeda H, Fukai S, Komatsu H, Kawahara M

    Japanese journal of clinical oncology   36 ( 1 )   7 - 11   2006.01( ISSN:0368-2811

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  • EGFR Mutation status in Japanese lung cancer patients: genotyping analysis using LightCycler. Reviewed

    Sasaki H, Endo K, Konishi A, Takada M, Kawahara M, Iuchi K, Matsumura A, Okumura M, Tanaka H, Kawaguchi T, Shimizu T, Takeuchi H, Yano M, Fukai I, Fujii Y

    Clinical cancer research : an official journal of the American Association for Cancer Research   11 ( 8 )   2924 - 9   2005.04( ISSN:1078-0432

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1158/1078-0432.CCR-04-1904

    PubMed

  • EGFR Mutation status in Japanese lung cancer patients: genotyping analysis using LightCycler.

    Sasaki H, Endo K, Konishi A, Takada M, Kawahara M, Iuchi K, Matsumura A, Okumura M, Tanaka H, Kawaguchi T, Shimizu T, Takeuchi H, Yano M, Fukai I, Fujii Y

    Clinical cancer research : an official journal of the American Association for Cancer Research   11 ( 8 )   2924 - 9   2005.04( ISSN:1078-0432

  • Intermittent dosing of the farnesyl transferase inhibitor tipifarnib (R115777) in advanced malignant solid tumors: a phase I California Cancer Consortium Trial. Reviewed

    Lara PN Jr, Law LY, Wright JJ, Frankel P, Twardowski P, Lenz HJ, Lau DH, Kawaguchi T, Gumerlock PH, Doroshow JH, Gandara DR

    Anti-cancer drugs   16 ( 3 )   317 - 21   2005.03( ISSN:0959-4973

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    Publishing type:Research paper (scientific journal)  

    PubMed

  • Intermittent dosing of the farnesyl transferase inhibitor tipifarnib (R115777) in advanced malignant solid tumors: a phase I California Cancer Consortium Trial.

    Lara PN Jr, Law LY, Wright JJ, Frankel P, Twardowski P, Lenz HJ, Lau DH, Kawaguchi T, Gumerlock PH, Doroshow JH, Gandara DR

    Anti-cancer drugs   16 ( 3 )   317 - 21   2005.03( ISSN:0959-4973

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MISC

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Presentations

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Grant-in-Aid for Scientific Research

  • 多発肺がんモデルを用いた環境因子の肺がん発癌における役割の解明

    Grant-in-Aid for Scientific Research(C)  2017.04

Other subsidies, etc.

  • 再発非小細胞肺がんに対するエルロチニブとドセタキセルの比較第III 相試験 (DELTA)

    未設定  2009.04

Outline of education staff

  • 呼吸器内科学総論、胸部悪性腫瘍の診断と治療

Charge of on-campus class subject

  • Respiratory Medicine Critical Reading

    2024     Graduate school

  • Training program in Respiratory Medicine

    2024     Graduate school

  • Training program in Clinical Respiratory Medicine

    2024     Graduate school

  • Seminar in Respiratory Medicine Research

    2024     Graduate school

  • Seminar in Respiratory Medicine

    2024     Graduate school

  • Basic Course of Clinical Medicine

    2024     Graduate school

  • Clinical Medicine

    2024     Graduate school

  • 新「共通特論1」:臨床腫瘍学総論

    2024   Intensive lecture   Graduate school

  • 腫瘍学Ⅰ基盤講義:臨床腫瘍学概論

    2024   Intensive lecture   Graduate school

  • 初年次ゼミナール

    2024   Weekly class   Graduate school

  • 呼吸器内科学

    2022   Intensive lecture   Undergraduate

  • 呼吸器内科学

    2019     Undergraduate

  • 呼吸器内科学

    2018     Undergraduate

  • 呼吸器内科学

    2017     Undergraduate

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Faculty development activities

  • FD活動への貢献  2019

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    がんプロフェッショナル養成基盤事業の教育部門の責任者として関与

  • FD活動への貢献  2018

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    がんプロフェッショナル養成基盤推進事業の教育改革分門の責任者として各種事業を立案し、実施した。

  • FD活動への貢献  2017

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    がんプロフェッショナル養成基盤推進事業の教育改革分門の責任者として各種事業を立案し、実施した。

Number of papers published by graduate students

  • 2021

    Number of graduate students presentations:2

Number of instructed thesis, researches

  • 2021

    [Number of doctoral thesis reviews] (chief):[Number of doctoral thesis reviews] (vice-chief):5

Original item・Special report (Education Activity)

  • 2021

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    Original item:がんプロフェッショナル養成基盤推進事業の教育改革分門の責任者として各種事業を立案し実施した。

  • 2020

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    Original item:がんプロフェッショナル養成基盤推進事業の教育改革分門の責任者として各種事業を立案し実施した。

Social Activities ⇒ Link to the list of Social Activities

  • 大阪府治験審査委員会委員

    Type: University open house, Cooperation business with The administrative, educational institutions, etc.

    2018.04 - Now

Academic Activities

  • 第116回日本肺癌学会関西支部学術集会会長

    Role(s): Planning, management, etc., Panel moderator, session chair, etc.

    日本肺癌学会  2022.06

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    Type:Academic society, research group, etc. 

  • Respiratory Investigation editor

    Role(s): Peer review

    呼吸器学会  2022.04 - Now

  • Internal Medicine editor

    Role(s): Peer review

    内科学会  2020.04 - Now

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    Type:Peer review 

Foreigner acceptance

  • 2017

    foreigners accepted :1

International exchange activities

  • 米国のSWOGと日本人のデータベースを利用して、分子疫学研究の共同研究を行っている。

    Field category :Research

    Country name :米国   2020.04 - Now

Job title

  • Job title within the department

    センター長  2014.04

Other

  • Job Career

    2018.04 - Now