Updated on 2024/03/26

写真a

 
SHINTANI Ayumi
 
Organization
Graduate School of Medicine Department of Clinical Medical Science Professor
School of Medicine Department of Medical Science
Title
Professor
Affiliation
Institute of Medicine
Profile
2000年に米国エール大学で生物統計学の博士号を取得後、テネシー州ヴァンダ―ビルト大学で講師准教授を経て、2013年より大阪大学医学部臨床統計疫学寄附講座教授。2016年より現職。ヴァンダービルト在籍中は医師研究者の育成を目的とした臨床研究修士コースで10年以上150人に及ぶ医師サイエンティストの育成に携わる。著書に「今日から使える医療統計(医学書院)」「みんなの医療統計(講談社)」「臨床研究を応援します(羊土社)」がある。日本REDCapコンソーシアム代表。 2022年9月にスタンフォード大学が発表した「世界で最も影響力のある研究者トップ2%」に生涯区分・単年区分両方で選出された。
Affiliation campus
Abeno Campus

Position

  • Graduate School of Medicine Department of Clinical Medical Science 

    Professor  2022.04 - Now

  • School of Medicine Department of Medical Science 

    Professor  2022.04 - Now

Degree

  • Doctor of Philosophy ( Others ) (   Yale University, U.S.A )

  • Master of Public Health ( Others ) (   Yale University, U.S.A )

Research Areas

  • Others / Others  / Biostatistics

Research Interests

  • Biostatistics

  • Data Management

  • Biostatistics

Research subject summary

  • Development of statistical methodology of analyzing and managing clinical and epidemiological research data.

Committee Memberships (off-campus)

  • 学術推進委員会 委員   日本呼吸療法医学会  

    2023.08 - 2024.06 

  • 厚生科学審議会臨時委員   厚生労働省 医政局 研究開発政策課  

    2023.07 - 2025.07 

  • 費用対効果評価専門組織   厚生労働省 保健局 医療課  

    2023.04 - 2025.04 

  • 費用対効果評価専門組織専門委員   厚生労働省保険局  

    2023.04 - 2025.04 

  • 成育疾患克服等総合研究事業課題評価委員会 委員   国立研究開発法人日本医療研究開発機構  

    2023.04 - 2025.03 

  • 包括的支援実用化研究事業課題評価委員会 委員   国立研究開発法人日本医療研究開発機構  

    2023.04 - 2025.03 

  • AMED課題評価委員   国立研究開発法人日本医療研究開発機構  

    2023.04 - 2025.03 

  • 大阪府救急医療対策審議会専門委員   大阪府  

    2023.04 - 2024.03 

  • 塩野義製薬の倫理委員会に出席し、科学的かつ倫理的に審議する   塩野義製薬株式会社  

    2023.04 - 2024.03 

  • 臨床研究の有益性向上について検討を行う   一般財団法人公正研究推進協会(APRIN)  

    2023.04 - 2024.03 

  • 研究開発課題評価に関する規則に基づく研究開発課題の評価   国立研究開発法人日本医療研究開発機構  

    2023.04 - 2024.03 

  • 研究開発課題評価に関する規則に基づく研究開発課題の評価   国立研究開発法人日本医療研究開発機構  

    2023.04 - 2024.03 

  • 統計調査委員会統計解析小委員会 委員   一般社団法人日本透析医学会  

    2022.09 - 2024.06 

  • 委員会 委員   一般財団法人日本集中治療医学会  

    2022.04 - 2023.03 

  • 医生命科学系分科会 委員   一般財団法人公正研究推進協会(APRIN)  

    2022 - 2024.06 

  • 臨床研究の有益性向上プロジェクト委員   一般財団法人公正研究推進協会  

    2022 - 2023.03 

▼display all

Job Career (off-campus)

  • Osaka City University   Graduate School of Medicine Clinical Medicine Course

    2017.04 - Now

  • 大阪大学   大学院医学系研究科臨床統計疫学寄附講座   寄附講座教授

    2013.10 - 2016.10

  • ヴァンダービルト大学医学部   内科 生物統計学   準教授

    2004.07 - 2013.09

  • ヴァンダービルト大学医学部   内科 生物統計学   講師

    2001.01 - 2004.06

  • 米国退役軍人病院   生物統計学研究員

    2000.06 - 2000.12

Education

  • Yale University, U.S.A   Department of Epidemiology and Public Health   Doctor's Course   Graduated/Completed

    1996.08 - 2000.05

  • Nara Women's University   Mathematics     Graduated/Completed

    1987.04 - 1991.03

Papers

  • Age and Pre-operative HbA1c levels affect renal function compensation in living kidney donors.

    Ito T, Kenmochi T, Kurihara K, Aida N, Hasegawa M, Ishihara T, Shintani A

    International urology and nephrology   56 ( 4 )   1315 - 1322   2024.04( ISSN:0301-1623

  • Advanced statistical analyses to reduce inconsistencies in bond strength data focused on donor factors: A six-factor analysis using linear mixed and nonlinear regression models

    Yamanaka Azusa, Mine Atsushi, Shintani Ayumi, Aoki-Matsumoto Mariko, Yumitate Masahiro, Ban Shintaro, Ishida Masaya, Takaishi Munechika, Yatani Hirofumi, Van Meerbeek Bart, Minamino Takuya, Ishigaki Shoichi

    Journal of Prosthodontic Research   advpub ( 0 )   2024.03( ISSN:1883-1958

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    <p><b>Purpose:</b> This study aimed to investigate the effects of the age and sex of tooth donors on dentin bond strength.</p><p><b>Methods:</b> A total of 38 extracted teeth (12 male and 26 female donors; age range: 17–82 years) were used in this study. In addition to donor age and sex, four other microtensile bond strength (μTBS) test specimen factors were evaluated: dentin position, bonding area, presence of voids at the interface, and computed tomography (CT) values of dentin. The μTBS was measured immediately (24 h) and 6 months after storage in water. After the μTBS testing, linear mixed and nonlinear regression models were used to analyze the effects of these factors on the μTBS data.</p><p><b>Results:</b> The results from the linear mixed model revealed that the bonding area (<i>P</i> = 0.02), presence of voids at the interface (<i>P</i> = 0.04), and storage time (<i>P</i> < 0.001) significantly affected bond strength. In contrast, no correlation was observed between the μ TBS and dentin position (<i>P</i> = 0.08) or sex (<i>P</i> = 0.07). The results of the nonlinear regression model with robust variance–covariance estimators revealed that age significantly affected bond strength (<i>P</i> < 0.001). In addition, a significant positive correlation was found between μTBS and age (<i>P</i> < 0.001), with nonlinearity (<i>P</i> = 0.002). However, no correlation was observed between the μTBS and CT values (<i>P</i> = 0.69) without nonlinearity (<i>P</i> = 0.39).</p><p><b>Conclusions:</b> These findings suggest that bond strength increases with age until 60 years but not afterward.</p>

    DOI: 10.2186/jpr.JPR_D_23_00193

    PubMed

  • Treatment sequencing after failure to alectinib in patients with anaplastic lymphoma kinase-positive non-small-cell lung cancer.

    Shimomura Y, Sawa K, Imai T, Ihara Y, Yoshida H, Shintani A

    Cancer science   115 ( 3 )   926 - 936   2024.03( ISSN:1347-9032

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  • Lack of Association Between Immunotherapy and Improvement of Survival for Non-small Cell Lung Cancer Patients With Hemodialysis: A Nationwide Retrospective Cohort Study.

    Sawa K, Ihara Y, Imai T, Sugimoto A, Nagamine H, Ogawa K, Nakahama K, Matsumoto Y, Tani Y, Kaneda H, Mitsuoka S, Kawaguchi T, Shintani A

    Clinical lung cancer   25 ( 2 )   144 - 150.e3   2024.03( ISSN:1525-7304

  • Prediction of Cochlear Implant Effectiveness With Surface-Based Morphometry.

    Minami S, Takahashi M, Shinden S, Shirai K, Oishi N, Nishimura H, Masuda M, Masuda S, Nishiyama T, Hosoya M, Ueno M, Kashio A, Yamada H, Matsunaga T, Kaga K, Shintani A, Nemoto K

    Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology   45 ( 2 )   114 - 120   2024.02( ISSN:1531-7129

  • Survey of students and guardians for assessing the early detection of auditory processing disorder and listening difficulties in school-age students.

    Sakamoto H, Sekido T, Sakamoto N, Obuchi C, Yoshida H, Shintani A

    International journal of pediatric otorhinolaryngology   176   111812   2024.01( ISSN:0165-5876

  • Continuous positive airway pressure versus high-flow nasal cannula oxygen therapy for acute hypoxemic respiratory failure: A randomized controlled trial.

    Nagata K, Yokoyama T, Tsugitomi R, Nakashima H, Kuraishi H, Ohshimo S, Mori Y, Sakuraya M, Kagami R, Tanigawa M, Tobino K, Kamo T, Kadowaki T, Koga Y, Ogata Y, Nishimura N, Kondoh Y, Taniuchi S, Shintani A, Tomii K, JaNP-Hi Study Investigators

    Respirology (Carlton, Vic.)   29 ( 1 )   36 - 45   2024.01( ISSN:1323-7799

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  • Immune Checkpoint Inhibitor Is Associated with Improved Survival in Advanced Non-small Cell Lung Cancer Occurring in Patients with Autoimmune Disease

    Ihara Yasutaka, Sawa Kenji, Imai Takumi, Nonomiya Yuta, Shimomura Yuki, Ishihara Asahi, Shintani Ayumi

    Biological and Pharmaceutical Bulletin   47 ( 2 )   454 - 461   2024( ISSN:0918-6158

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    <p>The use of immune checkpoint inhibitors (ICIs) has revolutionized the treatment of advanced non-small cell lung cancer (NSCLC). However, clinical trials often exclude those with a history of autoimmune diseases (ADs) because of concerns regarding immune-related adverse events. Therefore, the efficacy of ICIs in advanced NSCLC patients with ADs should be evaluated. This study used administrative claims data from advanced treatment centers in Japan and identified patients with advanced NSCLC who began chemotherapy between December 2016 and January 2023. The patients were divided into four groups based on the presence of ADs and types of chemotherapy received. The association between ICI therapy and overall survival in the subgroups with or without ADs, and the association between the presence of AD and overall survival in patients who received ICI therapy and conventional chemotherapy, were analyzed using Cox proportional hazard regression, including therapy and presence of ADs and their interaction as covariates. These results were obtained using the inverse probability of treatment weighting. ICI therapy had a hazard ratio (95% confidence interval) for death in the subgroup of AD and non-AD patients of 0.88 (0.84–0.92) and 0.83 (0.71–0.97), respectively (<i>p</i> = 0.459 for interaction). For some specific ADs, including type 1 diabetes mellitus, the association between ICI therapy and decreased mortality was not observed. In conclusion, our study showed comparable associations between ICI therapy and reduced mortality in AD and non-AD subgroups of patients with advanced NSCLC. However, therapy strategies tailored to each AD type and thorough discussions regarding the risk-benefit profile are crucial.</p>

    DOI: 10.1248/bpb.b23-00713

    PubMed

  • Association between immune-related adverse events and survival in patients with renal cell carcinoma treated with nivolumab plus ipilimumab: immortal time bias-corrected analysis(タイトル和訳中)

    Washino Satoshi, Shirotake Suguru, Takeshita Hideki, Inoue Masaharu, Miura Yuji, Hyodo Yoji, Kagawa Makoto, Izumi Keita, Oyama Masafumi, Kawakami Satoru, Saito Kazutaka, Matsuoka Yoh, Taniuchi Satsuki, Shintani Ayumi, Miyagawa Tomoaki

    International Journal of Clinical Oncology   28 ( 12 )   1651 - 1658   2023.12( ISSN:1341-9625

  • Relationship between Full-Thickness Macular Hole Onset and Posterior Vitreous Detachment: A Temporal Onset Theory.

    Sakaguchi H, Kabata D, Sakimoto S, Shiraki A, Fujimoto H, Fukushima Y, Hara C, Nishida K, Shintani A, Nishida K

    Ophthalmology science   3 ( 4 )   100339   2023.12

  • Association between immune-related adverse events and survival in patients with renal cell carcinoma treated with nivolumab plus ipilimumab: immortal time bias-corrected analysis.

    Washino S, Shirotake S, Takeshita H, Inoue M, Miura Y, Hyodo Y, Kagawa M, Izumi K, Oyama M, Kawakami S, Saito K, Matsuoka Y, Taniuchi S, Shintani A, Miyagawa T

    International journal of clinical oncology   28 ( 12 )   1651 - 1658   2023.12( ISSN:1341-9625

  • Vascular access site complications after transfemoral transcatheter aortic valve implantation: a comparison of open and percutaneous puncture approaches.

    Sumii Y, Morisaki A, Okai T, Taniuchi S, Shintani A, Kawase T, Nishiya K, Sakon Y, Fujii H, Shibata T, Takahashi Y

    Journal of thoracic disease   15 ( 11 )   5901 - 5912   2023.11( ISSN:2072-1439

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  • Renin-angiotensin-aldosterone system inhibitors are associated with improved paclitaxel-induced peripheral neuropathy in lung cancer: a study using administrative claims data.

    Ihara Y, Sawa K, Imai T, Kimura T, Otani M, Kawai R, Takatori S, Shintani A

    Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer   31 ( 12 )   730   2023.11( ISSN:0941-4355

  • A Phase I/II Clinical Trial of Intradermal, Controllable Self-Replicating Ribonucleic Acid Vaccine EXG-5003 against SARS-CoV-2.

    Koseki T, Teramachi M, Koga M, Ko MSH, Amano T, Yu H, Amano M, Leyder E, Badiola M, Ray P, Kim J, Ko AC, Achour A, Weng NP, Imai T, Yoshida H, Taniuchi S, Shintani A, Fujigaki H, Kondo M, Doi Y

    Vaccines   11 ( 12 )   2023.11( ISSN:2076-393X

  • Impact of HLA disparity on overall mortality risk in patients with extensive chronic GVHD: The HLA Working Group of Japanese Society for Transplantation and Cellular Therapy.

    Fuji S, Hakoda A, Kanda J, Fukuda T, Doki N, Katayama Y, Uchida N, Ozawa Y, Kanda Y, Tanaka M, Kataoka K, Ara T, Sawa M, Onizuka M, Onishi Y, Kimura T, Ichinohe T, Atsuta Y, Shintani A, Morishima S

    Bone marrow transplantation   58 ( 11 )   1257 - 1259   2023.11( ISSN:0268-3369

  • Hypothesis testing procedure for binary and multi-class F(1) -scores in the paired design.

    Takahashi K, Yamamoto K, Kuchiba A, Shintani A, Koyama T

    Statistics in medicine   42 ( 23 )   4177 - 4192   2023.10( ISSN:0277-6715

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  • Effect of a Community-Based Program to Accelerate Referral to Physicians for Individuals at High-Risk of Lifestyle-Related Diseases: A Cluster Randomized Trial(タイトル和訳中)

    Iso Hiroyasu, Noguchi Midori, Yokoyama Tetsuji, Yoshida Toshiko, Saito Isao, Shintani Ayumi, Sairenchi Toshimi, Nishizawa Hitoshi, Imano Hironori, Kitamura Akihiko, Shimomura Iichiro

    Journal of Atherosclerosis and Thrombosis   30 ( 10 )   1389 - 1406   2023.10( ISSN:1340-3478

  • Reduced incidence of cardiovascular disease in patients with type 2 diabetes through the integrated improvement of diabetes care by comparing two prospective observational cohorts in real-world clinical practice (JDDM 72).

    Yokoyama H, Araki SI, Kawai K, Yamazaki K, Tomonaga O, Maeda H, Ohtaki M, Obata H, Sone H, Kabata D, Shintani A, Maegawa H, JDDM study group

    Diabetes research and clinical practice   202   110674   2023.08( ISSN:0168-8227

  • Association between time-dependent changes in cerebrovascular autoregulation after cardiac arrest and outcomes: A prospective cohort study.

    Tachino J, Nonomiya Y, Taniuchi S, Shintani A, Nakao S, Takegawa R, Hirose T, Sakai T, Ohnishi M, Shimazu T, Shiozaki T

    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism   271678X231185658   2023.06( ISSN:0271-678X

  • 心内膜双極電位は左房後壁内部への追加通電の必要性を予測する(Endocardial Bipolar Voltage Predicts the Need for Additional Ablation Inside the Left Atrial Posterior Wall)

    Yanagishita Tomoya, Yoshiyama Tomotaka, Kawai Ryota, Toyoda Natsumi, Nakatsuji Kenichi, Izumiya Yasuhiro, Shintani Ayumi, Fukuda Daiju

    Osaka City Medical Journal   69 ( 1 )   1 - 9   2023.06( ISSN:0030-6096

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    肺静脈隔離(PVI)への左房後壁隔離(LA PWI)の追加はPVI単独よりも非発作性心房細動(AF)患者の予後を改善することが報告されている。本研究では、左房後壁内部への追加通電の必要性の予測因子を明らかするため、後ろ向きコホート研究を行った。2018年6月~2020年7月に当院で非発作性AFに対して初回のPVIとLA PWIを行った患者77例を対象とした。3Dマッピングシステムを用いて左房内の双極電位を記録した後にPVIとLA PWIを行った。天井ラインと底部ラインの作成でLA PWIが完成、もしくはライン上のgapへの追加通電で隔離が完成したA群35例(男性68.6%、平均68.2±8.3歳)と、それでは隔離できず左房後壁内部への通電が必要であったB群42例(男性78.6%、平均62.9±11.8歳)に分けた。最終的に全例でPVIが達成され、追加通電によって全例でLA PWIが達成された。A群はB群と比較して年齢が有意に高く、天井ライン上の最大電位と平均電位が有意に高かった。年齢を調整後の多変量解析では、天井ライン上の最大電位と平均電位が、後壁内部の追加通電の独立した予測因子であった。

  • 歩数計を用いたウォーキング促進プログラムにおける金銭的インセンティブの有効性(Effectiveness of Financial Incentives for a Pedometer-based Walking Promotion Program)

    Komiya Eriko, Taniuchi Satsuki, Shiba Masatsugu, Shintani Ayumi, Nakamura Hiroaki

    Osaka City Medical Journal   69 ( 1 )   31 - 39   2023.06( ISSN:0030-6096

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    インセンティブを伴うウォーキング促進プログラムの医療費削減効果について検討した。2016年10月~2018年3月に、大阪府高石市在住の40~75歳の市民16816名を対象に、毎日の歩数に応じてインセンティブが付与される歩行促進プログラムを実施した。参加希望者は市に参加登録し、自身のスマートフォンか活動量計のどちらかを選択、市内各地に設置された歩数登録端末を使用して自らの歩数を集計した。医療費データは国民健康保険のデータを使用した。プログラム参加群(1945名)と年齢・性別・医療費をマッチングさせた対照群(1945名)を設定し、年間医療費を比較した。順序ロジスティック回帰分析の結果、高石市在住者のサンプルにおいて、インセンティブを伴うウォーキング促進プログラムへの参加は1年間の医療費削減と相関していた。プログラム参加群と対照群の1年間における医療費の差は21261324円/年であった。インセンティブを伴うウォーキング促進プログラムは医療費削減の観点から有効な政策であると考えられた。

  • Artificial intelligence model to identify elderly patients with locomotive syndrome: A cross-section study.

    Takahashi S, Nonomiya Y, Terai H, Hoshino M, Ohyama S, Shintani A, Nakamura H

    Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association   28 ( 3 )   656 - 661   2023.05( ISSN:0949-2658

  • 高齢のロコモティブシンドローム患者の検出に用いられる人工知能モデル 横断研究(Artificial intelligence model to identify elderly patients with locomotive syndrome: A cross-section study)

    Takahashi Shinji, Nonomiya Yuta, Terai Hidetomi, Hoshino Masatoshi, Ohyama Shoichiro, Shintani Ayumi, Nakamura Hiroaki

    Journal of Orthopaedic Science   28 ( 3 )   656 - 661   2023.05( ISSN:0949-2658

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    高齢のロコモティブシンドローム(LS)患者の検出に用いられる人工知能(AI)ベースの決定システムを開発し、その有用性について検討した。高齢者409名(男性164名、女性245名、平均73.5±5.4歳)を対象に、横断研究を実施して足部スキャン圧システムとして歩行中の足底圧分布を測定し、さらに画像処理システムには畳み込みニューラルネットワーク(CNN)を用いて足底圧をベースにLSの発症可能性を推定した。AIモデルのロジスティック回帰段階では、年齢、性別、身長、体重およびCNNの出力にもとづいて発症予測方程式を作成した。開発コホートの対象者は300名で、このうち104名(34.7%)がLSと診断された。三分割交差検証データセットの平均確度はトレーニングセットが0.71、検証セットが0.68を示しており、CNN出力はLS発症群の方が健常者群より有意に高かった。開発コホートにおける平均AUCは0.84、臨床モデルの平均AUCは0.80であった。足底圧分布をベースとしたAIモデルはLSのスクリーニングに有用なツールであることが示された。

  • Effect of a Community-Based Program to Accelerate Referral to Physicians for Individuals at High-Risk of Lifestyle-Related Diseases: A Cluster Randomized Trial

    Iso Hiroyasu, Noguchi Midori, Yokoyama Tetsuji, Yoshida Toshiko, Saito Isao, Shintani Ayumi, Sairenchi Toshimi, Nishizawa Hitoshi, Imano Hironori, Kitamura Akihiko, Shimomura Iichiro, for J-HARP Research Group

    Journal of Atherosclerosis and Thrombosis   advpub ( 0 )   2023.03( ISSN:1340-3478

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    <p><b>Aim: </b>A cluster randomized trial was conducted within 41 Japanese municipalities (21 intervention and 22 usual care) to examine whether the standardized health counseling for individuals at high cardiovascular risk screened at community sites accelerates clinic visits to strengthen the primary health care system.<b> </b></p><p><b>Methods: </b>Among high-risk individuals aged 40–74 years screened by health checkups, 8,977 and 6,733 were allocated to the intervention and usual care groups, respectively, who were not under medical treatment but had high levels of blood pressure (systolic/diastolic ≥ 160/100 mmHg), hemoglobin A1c or glucose (≥ 7.0% or corresponding glucose levels), LDL-cholesterol (≥ 180 mg/dL for men), and/or proteinuria of ≥ 2+. The intervention was performed from May 2014 to March 2016 under a standardized health counseling program based on the health belief model primarily by public health nurses. The usual care group was provided with local counseling protocols.<b> </b></p><p><b>Results: </b>The cumulative proportions of clinic visits for 12 months after health checkups were 58.1% (95% confidence interval, 57.0%, 59.3%) versus 44.5% (43.2%, 45.8%), with the probability ratio of clinic visits between the groups being 1.46 (1.24, 1.72). The between-group differences between the baseline and 1-year surveys were −1.50 (−2.59, −0.41) mmHg for diastolic blood pressure in the hypertension category, −0.30% (−0.53%, −0.07%) for HbA1c in the diabetes category, −0.37 (−0.48, −0.27) mmol/L for LDL-cholesterol in the dyslipidemia category, and none for proteinuria.<b> </b></p><p><b>Conclusion: </b>Standardized health counseling for high-risk individuals accelerated clinic visits, with larger reductions in blood pressure, HbA1c, and LDL-cholesterol levels. The nationwide use of counseling after health checkups for high-risk individuals could help in controlling risk factors and in preventing lifestyle-related diseases.</p>

    DOI: 10.5551/jat.64100

    PubMed

  • Augmenting Granzyme B-Expressing NK Cells by Invariant NKT Ligand-Loaded APCs in Patients with Postoperative Early Stage Non-Small Cell Lung Cancer: Results of a Randomized Phase II Study.

    Iyoda T, Shimizu K, Kawamura M, Shinga J, Watanabe T, Fukunaga K, Mushiroda T, Saka H, Kitagawa C, Shimamatsu SI, Takenoyama M, Suehiro Y, Imai T, Shintani A, Ito S, Fujii SI

    ImmunoHorizons   7 ( 1 )   1 - 16   2023.01

  • Exploring the threshold for the start of respiratory syncytial virus infection epidemic season using sentinel surveillance data in Japan.

    Miyama T, Kakimoto K, Iritani N, Nishio T, Ukai T, Satsuki Y, Yamanaka Y, Nishida Y, Shintani A, Motomura K

    Frontiers in public health   11   1062726   2023

  • Survey on the Impact of the COVID-19 Pandemic on Patients with Parkinson's Disease and Their Caregivers in Japan.

    Hattori N, Okada Y, Kawata Y, Furusawa Y, Imai T, Yoshida H, Ota M, Arai M, Shintani A, Fernandez J

    Patient preference and adherence   17   1221 - 1235   2023( ISSN:1177-889X

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  • Real-world evidence on levodopa dose escalation in patients with Parkinson's disease treated with istradefylline.

    Hattori N, Kabata D, Asada S, Kanda T, Nomura T, Shintani A, Mori A

    PloS one   18 ( 12 )   e0269969   2023

  • Matching on propensity and prognostic scores can lead to different estimates of heterogeneous treatment effects: a case study and simulation

    Kabata D.

    Health Services and Outcomes Research Methodology   2023( ISSN:13873741

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  • Differences in Driver Behavior between Manual and Automatic Turning of an Inverted Pendulum Vehicle.

    Nakagawa C, Yamada S, Hirata D, Shintani A

    Sensors (Basel, Switzerland)   22 ( 24 )   2022.12( ISSN:14248220

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  • Associations of time-dependent changes in phosphorus levels with cardiovascular diseases in patients undergoing hemodialysis: results from the Japan Dialysis Active Vitamin D (J-DAVID) randomized clinical trial.

    Koshi-Ito E, Inaguma D, Ishii H, Yuzawa Y, Kabata D, Shintani A, Inaba M, Emoto M, Mori K, Morioka T, Nakatani S, Shoji T

    Clinical kidney journal   15 ( 12 )   2281 - 2291   2022.12( ISSN:2048-8505

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  • Effects of alfacalcidol on cardiovascular outcomes according to alkaline phosphatase levels in the J-DAVID trial.

    Oka T, Sakaguchi Y, Isaka Y, Ishii H, Kabata D, Shintani A, Nakatani S, Morioka T, Mori K, Inaba M, Emoto M, Shoji T

    Scientific reports   12 ( 1 )   15463   2022.09

  • Effect of Music in Reducing Pain during Hemodialysis Access Cannulation: A Crossover Randomized Controlled Trial.

    Inayama E, Yamada Y, Kishida M, Kitamura M, Nishino T, Ota K, Takahashi K, Shintani A, Ikenoue T

    Clinical journal of the American Society of Nephrology : CJASN   17 ( 9 )   1337 - 1345   2022.09( ISSN:1555-9041

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  • 日本のICUにおけるSequential Organ Failure Assessmentスコア算定に用いられるGlasgow昏睡尺度とPaO2/FIO2比の評価法サーベイ(Survey of Glasgow Coma Scale and PaO2/FIO2 ratio assessment methods for the Sequential Organ Failure Assessment score in Japanese intensive care units)

    Tamoto Mitsuhiro, Imai Takumi, Aida Rei, Harada Yusuke, Wakabayashi Yuki, Satone Gaku, Ichoda Shunsuke, Unoki Takeshi, Shintani Ayumi

    Acute Medicine & Surgery   9 ( 1 )   1 of 9 - 9 of 9   2022.09

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    日本のICUにおけるSequential Organ Failure Assessment(SOFA)スコアのコンポーネントとしてのGlasgow昏睡尺度(GCS)とPaO2/FIO2比(P/F比)の評価方法を検討した。ICUの医療従事者を対象に横断調査研究を実施した。414名から回答が得られ、最終的に175施設の211名を解析対象とした。鎮静剤の影響下においてGCSを評価する際に推定GCSを用いていたのは45.1%(95%CI 37.6~52.8)であった。P/F比の算出に関して、患者が酸素マスクを装着している場合はJIPADの定義文書に基づくとする回答が最も多かった。ECMO装着患者の場合には人工呼吸器からのFIO2をベースとするという回答が最も多かった。鎮静剤の影響下にある患者の推定GCSの評価は困難と考える医療従事者が約60%であった。妥当なSOFAスコアを得るためには、GCSとP/F比の測定方法の標準化が必要と考えられた。

  • A Larger Membrane Area Increases Cytokine Removal in Polymethyl Methacrylate Hemofilters.

    Nakamura T, Moriyama K, Kuriyama N, Hara Y, Komatsu S, Kawaji T, Kato Y, Ishihara T, Shintani A, Nishida O

    Membranes   12 ( 8 )   2022.08( ISSN:2077-0375

  • Four-year clinical evaluation of CAD/CAM indirect resin composite premolar crowns using 3D digital data: Discovering the causes of debonding

    Kabetani Tomoshige, Ban Shintaro, Mine Atsushi, Ishihara Takuma, Nakatani Hayaki, Yumitate Masahiro, Yamanaka Azusa, Ishida Masaya, Matsumoto Mariko, Meerbeek Bart Van, Shintani Ayumi, Yatani Hirofumi

    Journal of Prosthodontic Research   66 ( 3 )   402 - 408   2022.07( ISSN:1883-1958

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    <p><b>Purpose:</b> To analyze the causes of debonding of computer-aided design/computer-aided manufacturing (CAD/CAM) indirect resin composite premolar crowns with a focus on the morphological factors of the crown and abutment teeth.</p><p><b>Methods:</b> The clinical courses of 109 CAD/CAM indirect resin composite crowns were observed, and the patients’ background characteristics, crown locations, luting methods, types of abutments, distal-most/non-distal-most molars, and types of resin blocks were confirmed. To investigate the influence of the morphology of the crown and abutment teeth, the 1) vertical dimension of the abutment teeth, 2) taper, and 3) thickness of the crown occlusal surface during events were measured from the three-dimensional digital data. The Kaplan-Meier method and multivariable Cox proportional hazard model were used for the statistical analyses. The nonlinearity of the effect of each comparison factor was included in the model.</p><p><b>Results:</b> Complications included 21 debonding cases, two crown fractures, five root fractures, and two core debondings. The cumulative no-debonding and no-crown-fracture rate over 1423 days (3 years and 11 months) was 77.4%. The multivariable Cox regression analysis revealed that the abutment teeth type of tooth (first or second premolar) (P = 0.02) and luting materials (P < 0.01) significantly influenced the debonding frequency. All morphological factors (1-3) significantly influenced the debonding. The hazard ratios and nonlinear graph indicated that the crown thickness was less effective than the vertical dimension and taper.</p><p><b>Conclusion:</b> The combination analysis of clinical outcomes and 3D digital data revealed that preparation of the abutment is important for avoiding crown debonding.</p>

    DOI: 10.2186/jpr.JPR_D_20_00287

    PubMed

    CiNii Article

  • An Examination of Donor Factors That Impact the Results of the Glucagon Stimulation Test as an Assessment of the Pancreatic Graft Endocrine Function.

    Ito T, Kenmochi T, Aida N, Hiratsuka I, Matsushima H, Kurihara K, Suzuki A, Shibata M, Kusaka M, Hasegawa M, Ishihara T, Go H, Yabusaki K, Shintani A

    Pancreas   51 ( 6 )   634 - 641   2022.07( ISSN:0885-3177

  • Four-year clinical evaluation of CAD/CAM indirect resin composite premolar crowns using 3D digital data: Discovering the causes of debonding(タイトル和訳中)

    Kabetani Tomoshige, Ban Shintaro, Mine Atsushi, Ishihara Takuma, Nakatani Hayaki, Yumitate Masahiro, Yamanaka Azusa, Ishida Masaya, Matsumoto Mariko, Meerbeek Bart Van, Shintani Ayumi, Yatani Hirofumi

    Journal of Prosthodontic Research   66 ( 3 )   402 - 408   2022.07( ISSN:1883-1958

  • Gut Dysbiosis Associated with Antibiotics and Disease Severity and Its Relation to Mortality in Critically Ill Patients.

    Ojima M, Shimizu K, Motooka D, Ishihara T, Nakamura S, Shintani A, Ogura H, Iida T, Yoshiya K, Shimazu T

    Digestive diseases and sciences   67 ( 6 )   2420 - 2432   2022.06( ISSN:0163-2116

  • 急性顔面神経麻痺治療のためのメチルプレドニゾロンパルス静注療法のコルチコステロイド通常投与との効果の比較 傾向スコア解析(Comparing the Effects of Intravenous Methylpredonisolone Pulse Therapy with the Conventional dose of Corticosteroids for the Treatment of Acute Facial Nerve Palsy: A Propensity Score Analysis)

    Oishi Masahiro, Kouda Yuki, Amatsu Hisao, Yoshida Hisako, Shintani Ayumi, Sunami Kishiko

    Osaka City Medical Journal   68 ( 1 )   1 - 10   2022.06( ISSN:0030-6096

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    急性顔面神経麻痺治療におけるメチルプレドニゾロンパルス静注療法の有効性を評価するために、コルチコステロイド通常投与と比較する後ろ向き観察研究を行った。急性顔面神経麻痺の発症後7日以内に治療を始めた患者を対象とした。74例の顔面神経麻痺のデータを分析したが、48例はメチルプレドニゾロンパルス静注療法で、26例はコルチコステロイド通常投与で治療した。メチルプレドニゾロンパルス静注療法とコルチコステロイド通常投与による回復率は70.8%と84.6%で、治療期間の中央値は61日と30日であった。治療期間に関するKaplan-Meier曲線では両群間で有意差があり、コルチコステロイド通常投与群で治療期間が短縮した。以上より、メチルプレドニゾロンパルス静注療法がコルチコステロイド通常投与よりも優れていることを示す結果は得られなかった。

  • Trends in glycemic control in patients with insulin therapy compared with non-insulin or no drugs in type 2 diabetes in Japan: a long-term view of real-world treatment between 2002 and 2018 (JDDM 66).

    Yokoyama H, Araki SI, Yamazaki K, Kawai K, Shirabe SI, Oishi M, Kanatsuka A, Yagi N, Kabata D, Shintani A, Maegawa H, JDDM study group

    BMJ open diabetes research & care   10 ( 3 )   2022.05

  • Prediction Model of Extubation Outcomes in Critically Ill Patients: A Multicenter Prospective Cohort Study.

    Tanaka A, Kabata D, Hirao O, Kosaka J, Furushima N, Maki Y, Uchiyama A, Egi M, Shintani A, Morimatsu H, Mizobuchi S, Kotake Y, Fujino Y

    Journal of clinical medicine   11 ( 9 )   2022.04( ISSN:2077-0383

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  • JCS 2022 Guideline Focused Update on Diagnosis and Treatment in Patients With Stable Coronary Artery Disease

    Nakano Shintaro, Kohsaka Shun, Chikamori Taishiro, Fukushima Kenji, Kobayashi Yoshio, Kozuma Ken, Manabe Susumu, Matsuo Hitoshi, Nakamura Masato, Ohno Takayuki, Sawano Mitsuaki, Toda Koichi, Ueda Yasunori, Yokoi Hiroyoshi, Gatate Yodo, Kasai Tokuo, Kawase Yoshiaki, Matsumoto Naoya, Mori Hitoshi, Nakazato Ryo, Niimi Nozomi, Saito Yuichi, Shintani Ayumi, Watanabe Ippei, Watanabe Yusuke, Ikari Yuji, Jinzaki Masahiro, Kosuge Masami, Nakajima Kenichi, Kimura Takeshi, on behalf of the JCS Joint Working Group

    Circulation Journal   86 ( 5 )   882 - 915   2022.04( ISSN:1346-9843

  • Ivermectin administration is associated with lower gastrointestinal complications and greater ventilator-free days in ventilated patients with COVID-19: A propensity score analysis.

    Shimizu K, Hirata H, Kabata D, Tokuhira N, Koide M, Ueda A, Tachino J, Shintani A, Uchiyama A, Fujino Y, Ogura H

    Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy   28 ( 4 )   548 - 553   2022.04( ISSN:1341-321X

  • Effects of ipragliflozin on left ventricular diastolic function in patients with type 2 diabetes and heart failure with preserved ejection fraction: The EXCEED randomized controlled multicenter study.

    Akasaka H, Sugimoto K, Shintani A, Taniuchi S, Yamamoto K, Iwakura K, Okamura A, Takiuchi S, Fukuda M, Kamide K, Fujio Y, Nakatani S, Ogihara T, Rakugi H, EXCEED investigators

    Geriatrics & gerontology international   22 ( 4 )   298 - 304   2022.04( ISSN:1444-1586

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  • イベルメクチン投与は人工呼吸器装着COVID-19患者における胃腸合併症の低下と人工呼吸器離脱期間の増加に関連する 傾向スコア分析(Invermectin adiminstration is associated with lower gastrointestinal complications and greater ventilator-free days in ventilated patients with COVID-19: A propensity score analysis)

    Shimizu Kentaro, Hirata Haruhiko, Kabata Daijiro, Tokuhira Natsuko, Koide Moe, Ueda Akiko, Tachino Jotaro, Shintani Ayumi, Uchiyama Akinori, Fujino Yuji, Ogura Hiroshi

    Journal of Infection and Chemotherapy   28 ( 4 )   548 - 553   2022.04( ISSN:1341-321X

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    イベルメクチンが人工呼吸器装着COVID-19患者の消化管合併症と呼吸状態を改善するかどうか評価した。2020年12月~2021年5月にCOVID-19と診断され、ICUに入室後3日以内に人工呼吸器を装着された20歳以上を後ろ向きに登録した。入院後3日以内にイベルメクチンを投与された患者をイベルメクチン群、非投与患者を対照群とした。人工呼吸器離脱期間(VFD)を主要アウトカムとし、入院から4週間以内の下痢、逆流、消化管合併症を副次アウトカムとした。イベルメクチン群は39例、対照群は49例であった。イベルメクチン群の全ての患者のイベルメクチン忍容性は良好で有害事象は見られなかった。イベルメクチン群の患者は対照群の患者より年齢は低く、慢性腎臓病の頻度は低かった。イベルメクチン群の下痢、逆流、消化管合併症の頻度は対照群より有意に低かった。対照群と比べて、イベルメクチン群の気管挿管期間は有意に短くVFDは有意に増大した。イベルメクチン群のICU滞在中の死亡率は対照群より有意に低かった。逆確率重み付け法による傾向スコアを用いて共変量を調整後のコックス比例ハザードモデルでは、対照群と比較したイベルメクチン群の消化管合併症のハザード比は0.221であった。同様に共変量調整後の比例オッズモデルでは、対照群と比較したイベルメクチン群のVFDのオッズ比は1.920であった。

  • 駆出率が保持された心不全を有する2型糖尿病患者の左室拡張機能に対するイプラグリフロジンの作用 EXCEED多施設共同無作為化比較試験(Effects of ipragliflozin on left ventricular diastolic function in patients with type 2 diabetes and heart failure with preserved ejection fraction: The EXCEED randomized controlled multicenter study)

    Akasaka Hiroshi, Sugimoto Ken, Shintani Ayumi, Taniuchi Satsuki, Yamamoto Koichi, Iwakura Katsuomi, Okamura Atsunori, Takiuchi Shin, Fukuda Masahiro, Kamide Kei, Fujio Yasushi, Nakatani Satoshi, Ogihara Toshio, Rakugi Hiromi, EXCEED investigators

    Geriatrics & Gerontology International   22 ( 4 )   298 - 304   2022.04( ISSN:1444-1586

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    駆出率が保持された心不全を有する2型糖尿病患者を対象とした多施設、非盲検、無作為化試験を実施し、イプラグリフロジンが左室拡張機能へ及ぼす作用を調べた。患者をイプラグリフロジン群36例(男性22例、平均71.9±8.0歳)、従来治療群32例(男性19例、平均70.3±8.5歳)に分けて検討した。各時点(ベースライン、12週、24週)で心エコー、身体検査、NYHA分類、血液検査を実施した。主要評価項目は心エコーにおけるE/e'およびe'のベースラインから24週までの変化、副次評価項目はその他心エコーパラメータ、血漿NT-proBNP値、NYHA分類、ヘモグロビンA1c、血圧などとした。その結果、24週後、両群でE/e'の低下が認められた。両群間でE/e'、e'、各種心エコーパラメータ、血漿NT-proBNP値、NYHA分類、ヘモグロビンA1c、血圧の変化量に有意差は認められなかった。サブグループ解析の結果、イプラグリフロジン投与により、70歳以上の患者では左室心筋重量係数の低下、ベースラインのNT-proBNP≧400pg/mLの患者においてNT-proBNP値の低下が認められた。以上から、イプラグリフロジンは、特定の症例において、左室肥大の抑制やNT-proBNP値の低下に寄与する可能性があることが示された。

  • 本邦の診療現場におけるICU退室後のフォローアップに関する実態調査

    河合 佑亮, 一二三 亨, 小幡 賢吾, 飯田 有輝, 畠山 淳司, 山川 一馬, 中村 謙介, 卯野木 健, 川上 大裕, 中西 信人, 劉 啓文, 新谷 歩, 井上 茂亮, 西田 修, 日本集中治療医学会PICS対策・生活の質改善検討委員会

    日本集中治療医学会雑誌   29 ( 2 )   165 - 176   2022.03( ISSN:1340-7988

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    【目的】Post-intensive care syndrome(PICS)対策としてのICU退室後のフォローアップに関する実態を明らかにする。【方法】2021年5月7~31日に日本集中治療医学会会員が勤務するICUを対象とし,インターネット上での調査を実施した。【結果】110ユニットのICUのうち,75.5%でPICSという用語や疾患概念が周知・使用され,89.1%で早期リハビリテーションが実施されていたが,55.5%でPICSに関する評価が実施されていなかった。ICU退室先の部署への訪問,PICS外来,退院後の医療機関などへの病院からのPICSに関する情報提供の実施率は,それぞれ32.7%,3.6%,19.1%であった。これらの実施の主な障壁として,マンパワーやPICSに関する知識,組織の理解,診療報酬があった。【結論】ICU退室後のフォローアップの実施率の低さが明らかになった。実施の推進のためには,ICUはもとより,あらゆる医療機能へのPICSに関する啓発強化,エビデンス蓄積の上,診療報酬の評価などを通した医療資源の確保が必要である。(著者抄録)

  • Survey of Glasgow Coma Scale and PaO(2)/FIO(2) ratio assessment methods for the Sequential Organ Failure Assessment score in Japanese intensive care units.

    Tamoto M, Imai T, Aida R, Harada Y, Wakabayashi Y, Satone G, Ichoda S, Unoki T, Shintani A

    Acute medicine & surgery   9 ( 1 )   e785   2022.01

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  • Dialysate calcium, alfacalcidol, and clinical outcomes: A post-hoc analysis of the J-DAVID trial.

    Iseki K, Kabata D, Shoji T, Inaba M, Emoto M, Mori K, Morioka T, Nakatani S, Shintani A

    PloS one   17 ( 9 )   e0273195   2022

  • Estimating the treatment effect with propensity score when the effect varies by patient characteristics: A case study and simulation

    Kabata D.

    Communications in Statistics Case Studies Data Analysis and Applications   8 ( 2 )   368 - 380   2022

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  • Impact of HLA disparity on the risk of overall mortality in patients with grade II-IV acute GVHD on behalf of the HLA Working Group of Japan Society for Hematopoietic Cell Transplantation.

    Fuji S, Hakoda A, Kanda J, Murata M, Terakura S, Inamoto Y, Uchida N, Toya T, Eto T, Nakamae H, Ikegame K, Tanaka M, Kawakita T, Kondo T, Miyamoto T, Fukuda T, Ichinohe T, Kimura T, Atsuta Y, Shintani A, Morishima S

    Bone marrow transplantation   56 ( 12 )   2990 - 2996   2021.12( ISSN:0268-3369

  • Effectiveness of near-infrared spectroscopy-guided continuous chest compression resuscitation without rhythm check in patients with out-of-hospital cardiac arrest: The prospective multicenter TripleCPR 16 study.

    Takegawa R, Taniuchi S, Ohnishi M, Muroya T, Hayakawa K, Tachino J, Hirose T, Nakao S, Muratsu A, Sakai T, Hayashida K, Shintani A, Becker LB, Shimazu T, Shiozaki T

    Resuscitation   169   146 - 153   2021.12( ISSN:0300-9572

  • 特集 図解 分子メカニズムから理解する婦人科がんの薬物療法 【総論】 Ⅳ 臨床試験および薬事承認を理解するために必要な基礎知識 3.臨床試験結果を正しく理解するための統計学の基礎知識

    新谷 歩

    産婦人科の実際   70 ( 12 )   1428 - 1434   2021.11( ISSN:05584728

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  • Serological Testing Reveals the Hidden COVID-19 Burden among Health Care Workers Experiencing a SARS-CoV-2 Nosocomial Outbreak.

    Nakagama Y, Komase Y, Candray K, Nakagama S, Sano F, Tsuchida T, Kunishima H, Imai T, Shintani A, Nitahara Y, Kaku N, Kido Y

    Microbiology spectrum   9 ( 2 )   e0108221   2021.10

  • A Randomized Trial of Home Blood-Pressure Reduction by Alcohol Guidance During Outpatient Visits: OSAKE Study.

    Kabayama M, Akagi Y, Wada N, Higuchi A, Tamatani M, Tomita J, Nakata Y, Takiuchi S, Yamamoto K, Sugimoto K, Shintani A, Rakugi H, Kamide K

    American journal of hypertension   34 ( 10 )   1108 - 1115   2021.10( ISSN:0895-7061

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  • Changes in practice patterns in Japan from before to after JSDT 2013 guidelines on hemodialysis prescriptions: results from the JDOPPS.

    Tomo T, Larkina M, Shintani A, Ogawa T, Robinson BM, Bieber B, Henn L, Pisoni RL

    BMC nephrology   22 ( 1 )   339   2021.10

  • Clinical phenotypes from fatal cases of acute respiratory distress syndrome caused by pneumonia.

    Ichikado K, Kawamura K, Johkoh T, Fujimoto K, Shintani A, Hashimoto S, Eguchi Y, Yasuda Y, Anan K, Shingu N, Sakata Y, Hisanaga J, Nitawaki T, Iio M, Sekido Y, Nishiyama K, Nakamura K, Suga M, Ichiyasu H, Sakagami T

    Scientific reports   11 ( 1 )   20051   2021.10

  • [Biostatistical Methods for Understanding the Principle of Randomized Controlled Trials].

    Shintani A

    Brain and nerve = Shinkei kenkyu no shinpo   73 ( 9 )   999 - 1006   2021.09( ISSN:1881-6096

  • A Double-Blind, Placebo-Controlled Study of Ultrasound-Guided Pulsed Radiofrequency Treatment of the Saphenous Nerve for Refractory Osteoarthritis-Associated Knee Pain.

    Uematsu H, Osako S, Hakata S, Kabata D, Shintani A, Kawazoe D, Mizuno K, Fujino Y, Matsuda Y

    Pain physician   24 ( 6 )   E761 - E769   2021.09( ISSN:1533-3159

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  • ファビピラビル臨床試験コホートからのSARS-CoV-2のウイルス学的解析およびゲノム解析(Virological and genomic analysis of SARS-CoV-2 from a favipiravir clinical trial cohort)

    Suzuki Masahiro, Imai Takumi, Sakurai Aki, Komoto Satoshi, Ide Tomihiko, Lim Chang Kweng, Shintani Ayumi, Doi Yohei, Murata Takayuki

    Journal of Infection and Chemotherapy   27 ( 9 )   1350 - 1356   2021.09( ISSN:1341-321X

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    2020年3~5月にファビピラビル(FAV)の無作為化臨床試験に参加した患者の鼻咽頭試料を用いて、SARS-CoV-2のシーケンス解析を行った。患者49名のゲノム配列が確定し、クレード19B(n=5)が試験の早期にみられたが、大部分はクレード20B(n=37)であった。COVID-19発症から細胞変性効果(CPE)の陰性化までの日数は9日(中央値)であった。CPE陽性は発症からの時間、ウイルス量、年齢、および性別(男)と強く相関した。患者23名の初回(day1)と治療中(day5~8)のペアのゲノム配列を比較した結果、FAVを投与された1名で二つの非同義変異を含む三つの1塩基変異(SNV)がみられたが、RdRp遺伝子の変異ではなかった。他の22名にSNVはなかった。本研究でのゲノム分布から、SARS-CoV-2が初期に中国から日本に入り、続いてヨーロッパからの株に置き換わったと考えられた。FAV治療とCPEの間に相関はなく、FAV治療による耐性出現の証拠はなかった。

  • Virological and genomic analysis of SARS-CoV-2 from a favipiravir clinical trial cohort.

    Suzuki M, Imai T, Sakurai A, Komoto S, Ide T, Lim CK, Shintani A, Doi Y, Murata T

    Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy   27 ( 9 )   1350 - 1356   2021.09( ISSN:1341-321X

  • Impact of stroke history on the presence of cerebral microbleeds in hemodialysis patients.

    Naganuma T, Kabata D, Takemoto Y, Uchida J, Shintani A

    BMC neurology   21 ( 1 )   311   2021.08

  • Antiplatelet therapy and future intracerebral hemorrhage in hemodialysis patients with cerebral microbleeds.

    Naganuma T, Kabata D, Takemoto Y, Uchida J, Shintani A

    Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia   90   155 - 160   2021.08( ISSN:0967-5868

  • U-Shaped Association Between Intraoperative Net Fluid Balance and Risk of Postoperative Recurrent Atrial Tachyarrhythmia Among Patients Undergoing the Cryo-Maze Procedure: An Observational Study.

    Minami K, Kabata D, Kakuta T, Fukushima S, Fujita T, Shintani A, Yoshitani K, Ohnishi Y

    Journal of cardiothoracic and vascular anesthesia   35 ( 8 )   2392 - 2396   2021.08( ISSN:1053-0770

  • Laboratory prognostic score for predicting 14-day mortality in terminally ill patients with gynecologic malignancy.

    Onishi K, Kawai N, Mizuno K, Shintani A, Yuasa N

    International journal of clinical oncology   26 ( 7 )   1345 - 1352   2021.07( ISSN:1341-9625

  • 婦人科悪性癌を有する終末期患者の14日間内での死亡率を予測するLaboratory Prognostic Score(Laboratory prognostic score for predicting 14-day mortality in terminally ill patients with gynecologic malignancy)

    Onishi Kazuma, Kawai Natsuko, Mizuno Kimio, Shintani Ayumi, Yuasa Norihiro

    International Journal of Clinical Oncology   26 ( 7 )   1345 - 1352   2021.07( ISSN:1341-9625

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    婦人科悪性癌患者の短期予後予測(14日以内での死亡率予測)に向けて、今回、新規に血液検査データに基づく予後予測スコア"Laboratory Prognostic Score"を開発し、予測精度を検証した。2009年6月~2018年2月までの期間内に、著者等の緩和ケア病棟(PCU)に入室した婦人科悪性癌を有する終末期癌患者73例(平均年齢66±14歳)から得た、PCU退室前3ヵ月以内の血液検査データを蓄積し、各々の血液学的因子についてROC解析を行い、AUCを求め、血液検査後14日間の生存転帰に対する予測値を決定した。また、多変量ロジスティック回帰分析により、14日以内での死亡に対し独立した予後因子を特定し、本スコアシステムを開発するため、婦人科悪性癌に対するlaboratory prognostic score(G-LPS)を独立予後因子の指標から算出した。多変量分析の結果、13.3mg/dL以上のCRP、1.1mg/dL以上の総ビリルビン、131mEq/L以下のNa、28mg/dL以上のBUN、17.7×10^3/μL以上の白血球数、0.2%以下の好酸球数の6指標が、14日生存の有意な独立因子として挙げられた。なお、G-LPSをこれら6指標の合計から求めた結果、G-LPS 3の最適なカットオフ値でのAUCは0.7977で、G-LPS 3による14日以内での死亡予測の感度と特異度は各々72%と79%であることが確認された。以上より、24項目の検査指標から6つの指標が、婦人科悪性癌の終末期患者の14日以内での死亡を予測する独立した予後因子として特定され、6指標により得られたG-LPSは、14日生存転帰予測において、許容範囲内の予測性能を有すると判断された。

  • 慢性腰痛患者に対する薬物治療の効果の比較 日本における全国規模の多施設共同研究(Comparison of the Effectiveness of Pharmacological Treatments for Patients with Chronic Low Back Pain: A Nationwide, Multicenter Study in Japan)

    Inoue Gen, Kaito Takashi, Matsuyama Yukihiro, Yamashita Toshihiko, Kawakami Mamoru, Takahashi Kazuhisa, Yoshida Munehito, Imagama Shiro, Ohtori Seiji, Taguchi Toshihiko, Haro Hirotaka, Taneichi Hiroshi, Yamazaki Masashi, Nishida Kotaro, Yamada Hiroshi, Kabata Daijiro, Shintani Ayumi, Iwasaki Motoki, Ito Manabu, Miyakoshi Naohisa, Murakami Hideki, Yonenobu Kazuo, Takura Tomoyuki, Mochida Joji

    Spine Surgery and Related Research   5 ( 4 )   252 - 263   2021.07

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    慢性腰痛患者471例を対象とした全国多施設共同前向き研究を実施し、代表的な4つの薬物療法の有効性を比較した。患者をアセトアミノフェン投与群94例(男性37例、女性57例、年齢中央値73.0歳)、セレコキシブ投与群170例(男性65例、女性102例、年齢中央値75.0歳)、ロキソプロフェン投与群89例(男性38例、女性50例、年齢中央値72.0歳)、トラマドール・アセトアミノフェン配合剤投与群118例(男性56例、女性62例、年齢中央値72.0歳)に分けて検討した。追跡期間は6ヵ月とし、月1回外来診察が行われた。評価項目は視覚的アナログスケール、日本整形外科学科会機能判定基準(JOAスコア)、JOA腰痛評価質問票(JOABPEQ)、Roland-Morris Disability Questionnaire、EuroQOL 5 dimension 3-level、SF-8とした。薬剤割り付け後1ヵ月および6ヵ月の時点で、線形重回帰分析を実施した。その結果、アセトアミノフェン投与群において、1ヵ月時点でJOABPEQ下位尺度の心理的障害スコア、6ヵ月時点でJOAスコアの改善が認められた(P=0.02、P<0.01)。その他の評価項目については、4剤間で有意差は認められなかった。また、全群に亘って、SF-8の精神的健康サマリースコアを除く全ての評価項目が同等に改善したが、殆どの評価項目で6ヵ月間の累積効果は明確でなかった。対照的に、SF-8の精神的健康サマリースコアは6ヵ月間の追跡期間中に全群において徐々に悪化していた。以上から、4剤の慢性腰痛に対する治療効果は同等であることが示された。

  • Evaluation of the effect of keratinized mucosa on peri-implant tissue health using a multivariate analysis

    Shimomoto Takuya, Nakano Tamaki, Shintani Ayumi, Ono Shinji, Inoue Masaki, Yatani Hirofumi

    Journal of Prosthodontic Research   65 ( 2 )   198 - 201   2021.06( ISSN:1883-1958

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    <i>Purpose:</i> This study investigated the relationship between peri-implant tissue health and the presence of keratinized mucosa (≥ 2 mm) using multivariate analysis.<br>
    <i>Methods:</i> A total of 334 dental implants placed in 111 partially edentulous patients (34 males, 77 females) and restored with fixed prostheses were included in this study. The patients were recalled 12–146 months after completion of the prosthodontic treatment. Clinical parameters included modified plaque index (mPI), modified bleeding index (mBI), probing pocket depth (PPD), and radiographic bone loss (BL). The effects of the following potential explanatory variables on these parameters were analyzed: the presence of keratinized mucosa, age, sex, oral hygiene status, history of periodontitis, cigarette smoking, implant site, and time elapsed since prosthesis delivery. Statistical analysis included multivariate ordinal logistic regression and generalized estimating equations. Significance wa s established when two-sided p-values were less than 0.05.<br>
    <i>Results:</i> The mPI, mBI, and PPD in the presence or absence of keratinized mucosa did not show statistically significant differences. However, the presence of keratinized mucosa was significantly related to BL (odds ratio 4.33, p < 0.01).<br>
    <i>Conclusions:</i> The results of our study suggest that the presence of keratinized mucosa is useful for reducing bone resorption and can help to maintain peri-implant tissue health

    DOI: 10.2186/jpr.JPOR_2019_391

    PubMed

    CiNii Article

  • Natural Kinetics of Blood Cells Following Major Burn Injury : Impact of Early Decreases in White Blood Cells and Plateletsas Prognostic Markers of Mortality

    Osuka Akinori, Ishihara Takuma, Shimizu Kentaro, Shintani Ayumi, Ogura Hiroshi, Ueyama Masashi

    Japanese Journal of Burn Injuries   47 ( 2 )   39 - 47   2021.06( ISSN:0285113X

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     Background: Severely burned patients often suffer white blood cell and platelet drop following injury. Though coagulopathy after burn injury has been reported, the association between leukopenia or thrombopenia and mortality is still unknown. This study was performed to determine whether early drastic drops in white blood cells (WBCs) and platelets following injury can be prognostic markers in patients with major burns.<br>
     Methods: This is a retrospective cohort study at a single Burn Center in Japan.<br>
     Data comprising the patients’ characteristics and blood cell counts (red blood cells [RBCs], WBCs including neutrophils, monocytes, and lymphocytes, and platelets) over the first 30 days after burn injury were serially collected from patients suffering major burn injury (≥20 %TBSA) from January 1, 2006, to December 31, 2015. To determine blood cell counts affecting the 60-day mortality, we used multivariable Cox proportional hazard analysis to assess associations between each blood cell count and the mortality, adjusting for age and %TBSA as covariates, and evaluated the predicted value of the hazard ratio (HR) of death.<br>
     Results: We enrolled 280 patients. Following burn injury, all blood cell counts were high on admission, and then decreased. RBCs diminished progressively and plateaued 2 weeks after injury. WBCs decreased suddenly 2 days after injury, then increased and stabilized. Platelets decreased more rapidly than WBCs to their nadir at 3 days, then continually increased. After covariate adjustment, low RBCs from day 1 (HR: 0.566, 95% C.I. 0.423, 0.759) to day 5 (HR: 0.524, 95% C.I. 0.175, 0.576) were predictors of mortality. Neutrophil count was not a risk factor, but day 3 lymphocyte count (HR: 0.131, 95% C.I. 0.026, 0.646) and day 10 monocyte count (HR: 0.044, 95% C.I. 0.005, 0.396) were risk factors. Low platelet counts from day 3 (HR: 0.545, 95% C.I. 0.300, 0.981) to day 30 following injury were always a predictor of mortality.<br>
     Conclusions: Early thrombopenia and lymphopenia were independent risk factors for 60-day mortality, and prolonged thrombopenia and monocytopenia were independent risk factors for mortality. These findings may shed light on the mechanisms of immune response following severe burns.<br>

    DOI: 10.34366/jburn.47.2_39

    CiNii Article

  • 喫煙とRhododendrol誘発性脱色素斑の重症度および白斑黒皮症発症との関連性(Smoking is Associated with the Severity of Rhododendrol-induced Leukoderma and with the Occurrence of Leukomelanoderma)

    Fukunaga Yoshie, Fukai Kazuyoshi, Umekoji-Hayashi Ayano, Ishihara Takuma, Shintani Ayumi, Tsuruta Daisuke

    Osaka City Medical Journal   67 ( 1 )   1 - 8   2021.06( ISSN:0030-6096

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    Rhododendrol(RD)誘発性脱色素斑の治療のため来院した患者における脱色素斑の重症化と白斑黒皮症の発症に関わるリスク因子を後ろ向きに調査した。RD含有化粧品を使用した後に脱色素斑を発症した女性患者101例(年齢中央値60歳)を対象とした。多変量ロジスティック回帰分析の結果、年齢、RDを含有する化粧品の使用数、BMI、抗核抗体および抗甲状腺抗体の使用は脱色素斑の重症度と有意な関連性はなかった。一方で、喫煙歴がある患者では喫煙歴がない患者と比較して初診時の脱色素斑の重症度が有意に高かった(p=0.012)。また、喫煙中の患者において白斑黒皮症の発症が高かった(p=0.006)が、他の因子は白斑黒皮症の発症と有意な関連性はなかった。Mann-Whitney U検定の結果では、喫煙歴がある患者(脱色素スコア中央値26)では喫煙歴がない患者(脱色素スコア中央値13)と比較して初診時の脱色素斑の重症度が有意に高かった(p=0.03)。以上の結果より、喫煙がRD誘発性の脱色素斑の重症化と白斑黒皮症発症のリスク因子であることが示された。

  • 重症熱傷後の血球数の推移と予後に与える影響

    大須賀 章倫, 石原 拓磨, 清水 健太郎, 新谷 歩, 小倉 裕司, 上山 昌史

    熱傷   47 ( 2 )   39 - 47   2021.06( ISSN:0285-113X

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    【背景】重症熱傷患者において受傷後に白血球や血小板が低下することはしばしば経験する.熱傷後の凝固異常に関する論文はあるが,白血球減少や血小板減少と予後との関連性に関してはいまだ明らかでない.本研究の目的は受傷後早期の白血球減少と血小板減少が重症熱傷患者の予後予測因子となりうるかを検討することである.【方法】本研究は単施設後方視的研究である.2006年1月1日から2015年12月31日までに当院熱傷センターに入院した熱傷面積20%以上の重症熱傷患者を対象とした.患者背景,血球数(赤血球,白血球,血小板および好中球,単球,リンパ球)を受傷から30日後まで診療録から抽出した.血球数が60日死亡に与える影響を検討するために,各血球数と死亡との関連を年齢と熱傷面積を共変量として調整した多変量Cox比例ハザード解析を用いて死亡のハザードとして算出した.【結果】280人の患者が対象となった.すべての血球数は受傷後に高値を示したが,その後減少した.赤血球は徐々に減少し,受傷後2週間で安定した.白血球は受傷2日後に急激に減少し,その後増加し安定した.血小板は白血球よりも急速に減少し,3日後に最低値に達したのち継続的に増加した.共変量調整後,赤血球数が少ないことは1日目(HR:0.566,95%C.I.0.423,0.759)から5日目まで(HR:0.524,95%C.I. 0.175,0.576)死亡の予測因子であった.好中球数は危険因子ではなかったが,3日目のリンパ球数低値(HR:0.131,95%C.I. 0.026,0.646)と10日目の単球数低値(HR:0.044,95%C.I. 0.005,0.396)は危険因子であった.受傷後3日目(HR:0.545,95%C.I. 0.300,0.981)から30日目までの血小板数低値は常に死亡の予測因子であった.【結語】初期の血小板減少とリンパ球減少は60日死亡の独立した危険因子であり,遷延する血小板減少と単球減少も死亡の独立した危険因子であった.これらの所見は,重症熱傷後の免疫応答のメカニズムを明らかにする可能性がある.(著者抄録)

  • 角化粘膜がインプラント周囲組織の健康に及ぼす影響の多変量解析を用いた評価(Evaluation of the effect of keratinized mucosa on peri-implant tissue health using a multivariate analysis)

    Shimomoto Takuya, Nakano Tamaki, Shintani Ayumi, Ono Shinji, Inoue Masaki, Yatani Hirofumi

    Journal of Prosthodontic Research   65 ( 2 )   198 - 201   2021.06( ISSN:1883-1958

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    インプラント周囲組織の健康状態と、角化粘膜が幅2mm以上にわたって存在する事との関連性を多変量解析によって調べた。歯科大学病院で2013年5月~2016年3月に部分無歯顎に対してインプラント計334本を設置し、固定性補綴治療を行った患者111名(女性77名、平均59.5±11.8歳)を組入れた。治療完了から12~146ヵ月後に評価を行った。評価した指標のうち、改良プラーク指数、改良出血指数、歯周ポケットの深さの3種には、角化粘膜の有無により統計学的に有意な差は生じていなかった。しかし、角化粘膜の存在は、放射線学的に評価された骨吸収と有意に関連していた(オッズ比4.33、p<0.01)。本研究結果から、角化粘膜が存在することは、骨吸収を減少させるために有利に働き、インプラント周囲組織の健康状態維持を助けることができると示唆された。

  • Association of the Yips and Musculoskeletal Problems in Highly Skilled Golfers: A Large Scale Epidemiological Study in Japan.

    Gon Y, Kabata D, Kawamura S, Mihara M, Shintani A, Nakata K, Mochizuki H

    Sports (Basel, Switzerland)   9 ( 6 )   2021.05

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  • Why participation in an international clinical trial platform matters during a pandemic? Launching REMAP-CAP in Japan.

    Kamata K, Jindai K, Ichihara N, Saito H, Kato H, Kunishima H, Shintani A, Nishida O, Fujitani S

    Journal of intensive care   9 ( 1 )   34   2021.04( ISSN:2052-0492

  • Gender-specific analysis for the association between trunk muscle mass and spinal pathologies.

    Hori Y, Hoshino M, Inage K, Miyagi M, Takahashi S, Ohyama S, Suzuki A, Tsujio T, Terai H, Dohzono S, Sasaoka R, Toyoda H, Kato M, Matsumura A, Namikawa T, Seki M, Yamada K, Habibi H, Salimi H, Yamashita M, Yamauchi T, Furuya T, Orita S, Maki S, Shiga Y, Inoue M, Inoue G, Fujimaki H, Murata K, Kawakubo A, Kabata D, Shintani A, Ohtori S, Takaso M, Nakamura H

    Scientific reports   11 ( 1 )   7816   2021.04

  • Comparative Effects of Etelcalcetide and Maxacalcitol on Serum Calcification Propensity in Secondary Hyperparathyroidism: A Randomized Clinical Trial.

    Shoji T, Nakatani S, Kabata D, Mori K, Shintani A, Yoshida H, Takahashi K, Ota K, Fujii H, Ueda S, Nishi S, Nakatani T, Yoshiyama M, Goto K, Hamada T, Imanishi M, Ishimura E, Kagitani S, Kato Y, Kumeda Y, Maekawa K, Matsumura T, Nagayama H, Obi Y, Ohno Y, Sai Y, Sakurai M, Sasaki S, Shidara K, Shoji S, Tsujimoto Y, Yamakawa K, Yasuda H, Yodoi S, Inaba M, Emoto M

    Clinical journal of the American Society of Nephrology : CJASN   16 ( 4 )   599 - 612   2021.04( ISSN:1555-9041

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  • Effect of Earlier Door-to-CT and Door-to-Bleeding Control in Severe Blunt Trauma: A Retrospective Cohort Study.

    Murao S, Yamakawa K, Kabata D, Kinoshita T, Umemura Y, Shintani A, Fujimi S

    Journal of clinical medicine   10 ( 7 )   2021.04( ISSN:2077-0383

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  • A Multicenter, Large-Scale Real-World Survey on Medication Adherence to Direct Oral Anticoagulants in Patients with Non-Valvular Atrial Fibrillation

    Miura Makoto, Onaga Shinichiro, Sugiyama Tetsuhiro, Ohama Naoko, Miyazato Yasutaka, Goda Takashi, Kokubu Chiyo, Nakamura Miki, Sasada Midori, Suzuki Masanori, Honda Kenichi, Hanamura Natsuki, Hamatake Kumiko, Akiyama Yuji, Tsutsui Yuka, Araki Tetsuya, Ibana Kazuhiro, Niinuma Yoshifumi, Morishima Yoshiyuki, Osada Shigeyuki, Takita Atsushi, Kimura Tetsuya, Yoshida Hisako, Shintani Ayumi, Seki Toshiichi

    Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences)   47 ( 3 )   132 - 144   2021.03( ISSN:1346342X

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    <p>Excellent medication adherence to direct oral anticoagulants (DOAC) is crucial for the prognostic improvement of patients with non-valvular atrial fibrillation (NVAF). However, the level of medication adherence to DOAC and factors affecting medication adherence are not fully understood in Japanese patients in real-world clinical practice.</p><p>To assess medication adherence, this study enrolled 817 NVAF outpatients who took DOAC in 16 hospitals. Hospital pharmacists investigated the medication adherence by pill count and evaluated the patients’ knowledge about disease and medication.</p><p>The percentage of prescribed pills taken was 97.49 ± 6.728%, indicating an excellent medication adherence to DOAC. The proportion of non-adherence patients by definition 1 (percentage of prescribed pills taken < 90% or no visit by the day after reaching the prescription days) was 8.9% and that by definition 2 (definition 1 + did not bring unconsumed drugs) was 19.3%. Regarding the levels of patients’ knowledge about disease and medication, approximately 20% of patients had no awareness of NVAF and 30% of patients did not understand the purpose of their medication. Additionally, several factors associated with non-adherence were identified by the multivariate binary logistic regression analysis. A common factor between the non-adherence by definition 1 and definition 2 was the low level of knowledge about medication.</p><p>This study demonstrated that Japanese NVAF patients who were taking DOAC had excellent adherence. However, it is suggested that pharmacists strengthen the intervention especially for patients with a low level of medication knowledge, which may lead to further improvement of medication adherence to DOAC.</p>

    DOI: 10.5649/jjphcs.47.132

  • Oxidative Stress and Inflammation as Predictors of Mortality and Cardiovascular Events in Hemodialysis Patients: The DREAM Cohort

    Sasaki Keyaki, Shoji Tetsuo, Kabata Daijiro, Shintani Ayumi, Okute Yujiro, Tsuchikura Shoko, Shimomura Naoko, Tsujimoto Yoshihiro, Nakatani Shinya, Mori Katsuhito, Shioi Atsushi, Inaba Masaaki, Emoto Masanori

    Journal of Atherosclerosis and Thrombosis   28 ( 3 )   249 - 260   2021.03( ISSN:1340-3478

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    <p><b>Aim:</b> Both oxidative stress and inflammation are involved in the pathogenesis of cardiovascular disease (CVD). The serum level of derivatives of reactive oxygen metabolites (d-ROMs) is a measure of the total amount of hydroperoxides serving as a marker of oxidative stress. We investigated whether d-ROMs could predict the clinical outcomes in hemodialysis patients and whether the associations of d-ROMs with the outcomes are independent of a marker of inflammation, C-reactive protein (CRP). </p><p><b>Methods:</b> This was a prospective cohort study in hemodialysis patients. The key exposures were the serum levels of d-ROMs and CRP. The outcome measures were all-cause mortality and new CVD events. </p><p><b>Results:</b> A total of 517 patients were analyzed. d-ROMs correlated positively with CRP. During follow-up for 5 years, 107 patients died, and 190 patients experienced new CVD events. In the Kaplan–Meier analyses, both higher d-ROMs and higher CRP levels predicted higher risks for mortality and CVD events. By Cox proportional-hazard regression analysis adjusted for potential confounders excluding CRP, d-ROMs exhibited a significant association with all-cause mortality, but this association was no longer significant after further adjustment for CRP. Using the same model, CRP exhibited a significant association with all-cause mortality, but this association was no longer significant after further adjustment for d-ROMs. When we analyzed new CVD events as the outcome, CRP was a significant predictor, whereas the level of d-ROMs was not. </p><p><b>Conclusions:</b> Although d-ROMs predicted mortality and CVD events in unadjusted models, the associations of d-ROMs with these outcomes were not independent of CRP. Oxidative stress and inflammation appear to share common causal pathways. </p>

    DOI: 10.5551/jat.56069

    PubMed

    CiNii Article

  • Effect of Empagliflozin as an Add-On Therapy on Decongestion and Renal Function in Patients With Diabetes Hospitalized for Acute Decompensated Heart Failure: A Prospective Randomized Controlled Study.

    Tamaki S, Yamada T, Watanabe T, Morita T, Furukawa Y, Kawasaki M, Kikuchi A, Kawai T, Seo M, Abe M, Nakamura J, Yamamoto K, Kayama K, Kawahira M, Tanabe K, Fujikawa K, Hata M, Fujita Y, Umayahara Y, Taniuchi S, Sanada S, Shintani A, Fukunami M

    Circulation. Heart failure   14 ( 3 )   e007048   2021.03( ISSN:1941-3289

  • 血液透析患者の死亡率および心血管イベントの予測因子としての酸化ストレスと炎症 DREAMコホート(Oxidative Stress and Inflammation as Predictors of Mortality and Cardiovascular Events in Hemodialysis Patients: The DREAM Cohort)

    Sasaki Keyaki, Shoji Tetsuo, Kabata Daijiro, Shintani Ayumi, Okute Yujiro, Tsuchikura Shoko, Shimomura Naoko, Tsujimoto Yoshihiro, Nakatani Shinya, Mori Katsuhito, Shioi Atsushi, Inaba Masaaki, Emoto Masanori

    Journal of Atherosclerosis and Thrombosis   28 ( 3 )   249 - 260   2021.03( ISSN:1340-3478

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    derivative of reactive oxygen metabolite(d-ROM)から血液透析患者の臨床成績を予測できるかどうか、d-ROMと臨床成績との関連がC反応性蛋白質(CRP)に非依存的かどうかを調べた。血液透析患者から血液検体を採取して、d-ROMアッセイを実施した。総死亡率と新規心血管疾患(CVD)イベントを評価した。血液透析患者517例(男性62.9%、中央値61歳)を解析した。d-ROMはCRPと正に関連した。5年間の経過観察期間中、107例が死亡し、190例が新規CVDイベントを経験した。Kaplan-Meier解析では高d-ROMと高CRPは死亡率とCVDイベントの高リスクを予測した。CRP以外の潜在的交絡因子を補正したコックス比例ハザード回帰分析では、d-ROMsは総死亡率と有意に関連したが、CRPを補正するとこの関連は有意ではなくなった。同じモデルでCRPは総死亡率と有意な関連を示したが、d-ROMsを補正するとこの関連は有意ではなくなった。新規CVDイベントを転帰として分析するとCRPは有意な予測因子であったが、d-ROMは有意な予測因子ではなかった。

  • 非弁膜性心房細動患者を対象とした直接作用型経口抗凝固薬の服薬アドヒアランスの多施設共同大規模実態調査

    三浦 誠, 翁長 真一郎, 杉山 哲大, 尾濱 直子, 宮里 弥篤, 合田 貴史, 國分 千代, 中村 美樹, 笹田 みどり, 鈴木 正論, 本田 憲一, 花村 菜月, 濱武 久美子, 秋山 裕史, 筒井 由佳, 荒木 哲也, 伊花 和宏, 新沼 芳文, 森島 義行, 長田 茂幸, 瀧田 厚, 木村 哲也, 吉田 寿子, 新谷 歩, 関 利一

    医療薬学   47 ( 3 )   132 - 144   2021.03( ISSN:1346-342X

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    直接作用型経口抗凝固薬(DOAC)を服用中の非弁膜症性心房細動(NVAF)患者にみられる服薬アドヒアランスの実態を調査した。16施設の共同研究施設を受診した外来診療中のNVAF患者817名を対象とした。DOAC服薬率は97.49±6.728%であった。服薬不遵守に関連する因子を、多変量2値ロジスティック回帰モデルを用いて解析した。その結果、服薬不遵守定義1(服薬率90%未満および処方日数到達日の翌日までに来院しなかった対象者)では75歳未満、薬識レベル低値の二つが服薬不遵守に有意に関連する因子であった。また、男性は服薬不遵守に関連する傾向がみられた。服薬不遵守定義2(残薬が多いために持参しなかった対象者)ではかかりつけ薬局/薬剤師がないことと薬識レベルが低いことが服薬不遵守に有意に関連する因子であった。また、院内処方および病識レベルが低いことが関連する傾向が認められた。

  • Seasonal shift in epidemics of respiratory syncytial virus infection in Japan.

    Miyama T, Iritani N, Nishio T, Ukai T, Satsuki Y, Miyata H, Shintani A, Hiroi S, Motomura K, Kobayashi K

    Epidemiology and infection   149   e55   2021.02( ISSN:0950-2688

  • Effect of long-term rigid gas-permeable contact lens wear on keratoconus progression.

    Araki S, Koh S, Kabata D, Inoue R, Morii D, Maeda N, Shintani A, Jhanji V, Nishida K

    The British journal of ophthalmology   105 ( 2 )   186 - 190   2021.02( ISSN:0007-1161

  • Predictors of the effects of smoking cessation on the endothelial function of conduit and digital vessels.

    Fukumoto K, Takemoto Y, Norioka N, Takahashi K, Namikawa H, Tochino Y, Shintani A, Yoshiyama M, Shuto T

    Hypertension research : official journal of the Japanese Society of Hypertension   44 ( 1 )   63 - 70   2021.01( ISSN:0916-9636

  • 導管血管および指尖血管の内皮機能に対する禁煙効果の予測因子(Predictors of the effects of smoking cessation on the endothelial function of conduit and digital vessels)

    Fukumoto Kazuo, Takemoto Yasuhiko, Norioka Naoki, Takahashi Kanae, Namikawa Hiroki, Tochino Yoshihiro, Shintani Ayumi, Yoshiyama Minoru, Shuto Taichi

    Hypertension Research   44 ( 1 )   63 - 70   2021.01( ISSN:0916-9636

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    血管内皮機能に対する禁煙の効果を血流依存性拡張反応(FMD)と反応性充血末梢動脈圧測定(RH-PAT)により評価し、その効果に関連する予測因子について検討した。禁煙成功者58名(平均64±11歳)と年齢、性を一致させた喫煙継続者21名を対象に、禁煙前および禁煙20週後の臨床検査値、FMD、および反応性充血指数の自然対数変換値(Ln-RHI)を解析した。禁煙成功者はFMDが有意に改善したが、Ln-RHIに著明な変化はなかった。両者の変化の関連性は、Spearmanの順位相関係数が-0.004で、級内相関係数が<0.001(p=0.499)であった。ロジスティック回帰分析でFMD増加と関連がみられた項目はBrinkman指数(オッズ比0.99,p=0.043)と禁煙前後の収縮期血圧変化(0.94,p=0.040)であり、Ln-RHI増加に関連する項目は収縮期血圧変化(1.06,p=0.047)と禁煙前BMI(0.83,p=0.032)であった。これらの項目が内皮機能に対する禁煙効果を予測し得る可能性が示唆された。

  • 慢性腰痛に対する薬物療法のアウトカムに影響を及ぼす背景因子 全国多施設共同前向き研究(Impact of background factors on outcomes of pharmacological therapy for chronic low back pain: A nationwide multicenter prospective study)

    Imagama Shiro, Murakami Hideki, Kaito Takashi, Matsuyama Yukihiro, Yamashita Toshihiko, Kawakami Mamoru, Takahashi Kazuhisa, Yoshida Munehito, Ohtori Seiji, Taguchi Toshihiko, Haro Hirotaka, Taneichi Hiroshi, Yamazaki Masashi, Inoue Gen, Nishida Kotaro, Yamada Hiroshi, Kabata Daijiro, Shintani Ayumi, Iwasaki Motoki, Ito Manabu, Miyakoshi Naohisa, Yonenobu Kazuo, Takura Tomoyuki, Mochida Joji, The Project Committee of the Japanese Society for Spine Surgery and Related Research(JSSR)

    Journal of Orthopaedic Science   26 ( 1 )   92 - 102   2021.01( ISSN:0949-2658

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    慢性腰痛(CLBP)に対する薬物療法のアウトカムに影響を及ぼす処方歴などの背景因子について検討した。CLBP患者474例(男性41.9%、中央値73.00歳)を対象に多施設共同前向き研究を実施し、6ヵ月の治療期間後にアウトカムを評価して、年齢、性別、BMI、CLBPの罹病期間、骨粗鬆症の有無、脊椎手術の既往、悪性腫瘍の病歴、喫煙習慣、就業状況などの背景因子の影響について検討した。アウトカムの評価には日本整形外科学会(JOA)スコア、腰痛VASスコア、JOA背部痛評価質問票(JOABPEQ)、Roland-Morris障害度質問票(RDQ)、簡易8項目健康サーベイ(SF-8)、EQ-5Dを用いた。処方薬はロキソニンが18.8%(89例)、セレコックスが36.5%(173例)、カロナールが19.6%(93例)、トラマセットが25.1%(119例)であった。神経因性疼痛治療薬投与、トラマセット投与、弱オピオイド投与およびNSAID投与が6ヵ月後の臨床アウトカムに有意な影響を及ぼしており、特に神経因性疼痛治療薬投与がアウトカムと負の相関を示していた。このほか、高齢はJOAスコア、JOABPEQ、SF-8スコアに負の影響を及ぼし、CLBPの罹病期間とJOA総スコア、脊椎手術の既往とJOA総スコア、喫煙習慣とSF-8との間に負の相関関係がみられた。また、男性、就労および運動習慣はJOABPEQに対して正の相関を有していた。

  • Comparison of the Effectiveness of Pharmacological Treatments for Patients with Chronic Low Back Pain: A Nationwide, Multicenter Study in Japan

    Inoue Gen, Kaito Takashi, Matsuyama Yukihiro, Yamashita Toshihiko, Kawakami Mamoru, Takahashi Kazuhisa, Yoshida Munehito, Imagama Shiro, Ohtori Seiji, Taguchi Toshihiko, Haro Hirotaka, Taneichi Hiroshi, Yamazaki Masashi, Nishida Kotaro, Yamada Hiroshi, Kabata Daijiro, Shintani Ayumi, Iwasaki Motoki, Ito Manabu, Miyakoshi Naohisa, Murakami Hideki, Yonenobu Kazuo, Takura Tomoyuki, Mochida Joji

    Spine Surgery and Related Research   5 ( 4 )   252 - 263   2021

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    <p>Introduction: Chronic low back pain (CLBP) is a leading cause of disability, yet there is limited high-quality evidence to identify the most suitable pharmacological therapy. The purpose of this Japanese nationwide, multicenter, prospective study was to compare the effectiveness of four representative drug therapies-acetaminophen, celecoxib, loxoprofen, and a tramadol and acetaminophen (T+A) combination drug-to establish evidence for a drug of choice for CLBP.</p><p>Methods: Patients with CLBP (N=471) received one of the four treatments and were evaluated, prospectively and comprehensively, once every month for six months using a visual analog scale (VAS) for LBP, the Japanese Orthopedic Association (JOA) score, the JOA Back Pain Evaluation Questionnaire (JOABPEQ), the Roland-Morris Disability Questionnaire (RDQ), the EuroQol five-dimensions three-levels (EQ-5D-3L), and the Short Form-8 item health survey (SF-8). We conducted multivariable linear regression analyses of the four drugs at 1 and 6 months after drug allocation. Differences with <i>P</i><0.05 were considered statistically significant.</p><p>Results: Patients who received acetaminophen showed a significant improvement from baseline in the mental health subscale of the JOABPEQ at one month (<i>P</i>=0.02) and the JOA score at six months (<i>P</i><0.01). None of the other outcome measures among the four drugs differed significantly. Across groups, all outcome measures, except the mental component summary (MCS) score of the SF-8, improved equivalently, although most measurements showed no obvious cumulative effect over six months. The MCS score of the SF-8 decreased gradually over six months in all groups.</p><p>Conclusions: Most of the outcome measures among the treated groups were not significantly different, indicating similar treatment effects of the four drugs for CLBP. Our study indicated the limit of each outcome measure for evaluating the patient status, suggesting that a single outcome measure is insufficient to reflect treatment effectiveness.</p>

    DOI: 10.22603/ssrr.2020-0083

    PubMed

    CiNii Article

  • Crosstalk Between NDP52 and LUBAC in Innate Immune Responses, Cell Death, and Xenophagy.

    Miyashita H, Oikawa D, Terawaki S, Kabata D, Shintani A, Tokunaga F

    Frontiers in immunology   12   635475   2021

  • Double-blinded randomized controlled trial to reveal the effects of Brazilian propolis intake on rheumatoid arthritis disease activity index; BeeDAI.

    Matsumoto Y, Takahashi K, Sugioka Y, Inui K, Okano T, Mandai K, Yamada Y, Shintani A, Koike T

    PloS one   16 ( 5 )   e0252357   2021

  • A double-blind, placebo-controlled study of ultrasound-guided pulsed radiofrequency treatment of the saphenous nerve for refractory osteoarthritis-associated knee pain

    Uematsu H.

    Pain Physician   24 ( 6 )   E761 - E769   2021( ISSN:15333159

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  • Patient and Physician Perspectives of Depressive Symptoms and Expectations for Treatment Outcome: Results from a Web-Based Survey.

    Ishigooka J, Hoshino T, Imai T, Yoshida H, Ono M, Ota M, Moriguchi Y, Fujikawa K, Shintani A, Fernandez JL

    Neuropsychiatric disease and treatment   17   2915 - 2924   2021( ISSN:1176-6328

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  • Safety and Efficacy of Tandem Hemodialysis and Selective Plasma Exchange in Pretransplant Desensitization of ABO-Incompatible Kidney Transplantation.

    Hanaoka A, Naganuma T, Kabata D, Morii D, Takemoto Y, Uchida J, Shintani A

    Blood purification   50 ( 6 )   829 - 836   2021( ISSN:0253-5068

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  • Multivariate analysis of the influence of prosthodontic factors on peri-implant bleeding index and marginal bone level in a molar site: A cross-sectional study.

    Inoue M, Nakano T, Shimomoto T, Kabata D, Shintani A, Yatani H

    Clinical implant dentistry and related research   22 ( 6 )   713 - 722   2020.12( ISSN:1523-0899

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  • A Prospective, Randomized, Open-Label Trial of Early versus Late Favipiravir Therapy in Hospitalized Patients with COVID-19.

    Doi Y, Hibino M, Hase R, Yamamoto M, Kasamatsu Y, Hirose M, Mutoh Y, Homma Y, Terada M, Ogawa T, Kashizaki F, Yokoyama T, Koba H, Kasahara H, Yokota K, Kato H, Yoshida J, Kita T, Kato Y, Kamio T, Kodama N, Uchida Y, Ikeda N, Shinoda M, Nakagawa A, Nakatsumi H, Horiguchi T, Iwata M, Matsuyama A, Banno S, Koseki T, Teramachi M, Miyata M, Tajima S, Maeki T, Nakayama E, Taniguchi S, Lim CK, Saijo M, Imai T, Yoshida H, Kabata D, Shintani A, Yuzawa Y, Kondo M

    Antimicrobial agents and chemotherapy   64 ( 12 )   2020.11( ISSN:0066-4804

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  • Identifying Septic Shock Populations Benefitting From Polymyxin B Hemoperfusion: A Prospective Cohort Study Incorporating a Restricted Cubic Spline Regression Model.

    Nakata H, Yamakawa K, Kabata D, Umemura Y, Ogura H, Gando S, Shintani A, Shiraishi A, Saitoh D, Fujishima S, Mayumi T, Kushimoto S, Abe T, Shiino Y, Nakada TA, Tarui T, Hifumi T, Otomo Y, Okamoto K, Kotani J, Sakamoto Y, Sasaki J, Shiraishi SI, Takuma K, Tsuruta R, Hagiwara A, Masuno T, Takeyama N, Yamashita N, Ikeda H, Ueyama M, Fujimi S, Japanese Association for Acute Medicine (JAAM) Focused Outcomes Research in Emergency Care in Acute Respiratory Distress Syndrome, Sepsis and Trauma (FORECAST) Study Group

    Shock (Augusta, Ga.)   54 ( 5 )   667 - 674   2020.11( ISSN:1073-2322

  • 急性心不全による入院患者における尿中アンジオテンシノーゲンと循環N末端プロB型ナトリウム利尿ペプチドの経時的変化(Time Course Changes in Urinary Angiotensinogen and Circulating N-Terminal Pro-B-Type Natriuretic Peptide in Patients Hospitalized with Acute Heart Failure)

    Yokoyama Shota, Kawakami Ryo, Tobiume Atsushi, Onishi Keisuke, Fujita Takuro, Ozaki Taro, Miyake Yuichi, Ishizawa Makoto, Noma Takahisa, Shintani Ayumi, Kuroda Yasuhiro, Minamino Tetsuo

    Internal Medicine   59 ( 22 )   2839 - 2847   2020.11( ISSN:0918-2918

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    心不全により単一施設に入院した患者45例(男性23例、平均76.9±11.7歳)を対象に、入院時と退院時の尿中アンジオテンシノーゲン(uAGT)、尿中クレアチニン(uCr)で正規化したuAGT(uAGT/uCr)を評価し、N末端プロB型ナトリウム利尿ペプチド(NT-proBNP)との関連性について検討した。入院期間は平均26.6±18.1日であった。入院時から退院時にかけて患者のNYHAスコアは有意に改善し(3→1)、それに伴って、uAGT/uCr中央値が有意に低下し(65.5→12.1μg/g Cr)、NT-proBNP中央値が有意に低下した(5422→903pg/mL)。心不全により再入院した5例において、入院時と再入院時のuAGT/uCrの経時的変化もNT-proBNPの経時的変化と関連していた。

  • Effects of Time from Onset or Diagnosis of Atrial Fibrillation to Catheter Ablation on Outcomes : The Role of Primary Care Physicians

    Matsumoto Yoshitaro, Kobori Atsushi, Kumagai Koichiro, Toyama Hideko, Yoshida Hisako, Shintani Ayumi, Sasaki Yasuhiro, Furukawa Yutaka

    Japanese Journal of Electrocardiology   40 ( 3 )   158 - 166   2020.10( ISSN:02851660

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    <p>Pulmonary vein isolation is a cornerstone treatment for atrial fibrillation(AF). Ablation centers have reported the efficacy of catheter ablation of AF. However, there are few reports examining the effects of time from onset or diagnosis of AF to catheter ablation procedure on clinical outcomes by primary care physicians. We examined the difference in treatment effect depending on the time from onset or diagnosis of paroxysmal or persistent AF to catheter ablation procedure to clarify the appropriate implementation time of AF treatment and role of primary care physicians. A total of 97 patients including 82 patients with paroxysmal AF and 15 patients with persistent AF were evaluated. The cure rate after the first catheter ablation procedure increased as the time from onset or diagnosis of AF to catheter ablation procedure decreased, regardless of age and degree of CHADS<sub>2</sub> score. It is important to determine the indication of catheter ablation as early as possible rather than rely on indeterminate antiarrhythmic medications alone. Early referring to a hospital that performs catheter ablation is an important thing primary care physicians can do to improve the prognosis of patients with AF.</p>

    DOI: 10.5105/jse.40.158

    CiNii Article

  • Impact of Blood Type O on Mortality of Sepsis Patients: A Multicenter Retrospective Observational Study.

    Hasegawa D, Nishida K, Kawaji T, Hara Y, Shimomura Y, Moriyama K, Niimi D, Kuriyama N, Shintani A, Komura H, Nishida O

    Diagnostics (Basel, Switzerland)   10 ( 10 )   2020.10( ISSN:2075-4418

  • Comparison of 1-year recurrence-free survival between sevoflurane and propofol use for general anesthesia management in primary breast cancer surgery.

    Shiono S, Shibata SC, Kabata D, Shintani A, Ikeda T, Fujino Y

    Journal of anesthesia   34 ( 5 )   694 - 701   2020.10( ISSN:0913-8668

  • 原発性乳癌手術の全身麻酔管理で使用するセボフルランとプロポフォールの1年無再発生存率の比較(Comparison of 1-year recurrence-free survival between sevoflurane and propofol use for general anesthesia management in primary breast cancer surgery)

    Shiono Shinnosuke, Shibata Sho C., Kabata Daijiro, Shintani Ayumi, Ikeda Takehiko, Fujino Yuji

    Journal of Anesthesia   34 ( 5 )   694 - 701   2020.10( ISSN:0913-8668

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    乳癌手術でセボフルラン(S)またはプロポフォール(P)を使用した患者における乳癌再発率を比較するため後ろ向き研究を行った。2008~2012年に原発性乳癌手術を受けた患者を対象とした。主要評価項目は1年無再発生存率とし、再発は局所領域の再発および遠隔転移とした。7変数(年齢、性別、BMI、癌の病期、腫瘍の大きさ、内因性サブタイプ、標準治療からの逸脱)から傾向スコアを計算し、再発の診断日からカプランマイヤー生存曲線を作成した。単変量Cox比例ハザード回帰分析からハザード比(HR)を推定した。解析した1026例のうち、Sは212例(うち女性209例、年齢中央値54.0歳)、Pは814例(うち女性810例、年齢中央値55.0歳)であった。いずれの患者でも区域麻酔の使用はなかった。追跡期間は中央値59ヵ月、全体の再発率はS群8.96%、P群9.33%で、再発リスクに有意差はなかった。1:1(各群159例)の傾向スコアマッチングを行った。その結果、1年再発率はS群7.5%、P群8.2%で、S群のP群に対する再発のHRは1.002(95%CI 0.457~2.198,p=0.995)であった。以上から、原発性乳癌手術患者において、区域麻酔なしでのSまたはPの使用は、1年後の再発リスクに影響を与えないようであった。

  • 心房細動発症または診断からカテーテルアブレーション治療までの期間と治療効果に関する検討 プライマリケア医の役割

    松本 善太郎, 小堀 敦志, 熊谷 浩一郎, 遠山 英子, 吉田 寿子, 新谷 歩, 佐々木 康博, 古川 裕

    心電図   40 ( 3 )   158 - 166   2020.10( ISSN:0285-1660

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    心房細動(atrial fibrillation:AF)に対するカテーテルアブレーションは、その高い治療効果から広く施行されるようになってきたが、術後の再発は課題のひとつである。その治療効果について、施行施設からの報告は多い。しかし、プライマリケアを行う医療機関からの、本邦におけるAFに対するカテーテルアブレーションの早期実施効果を検討した報告は少ない。今回われわれは、AFの発症または診断からカテーテルアブレーション治療までの期間による治療効果を検討した。当院を受診したAF患者のうちカテーテルアブレーションを施行した発作性AF82例と持続性AF15例を対象とした。カテーテルアブレーション術後3ヵ月以後に30秒以上持続する心房性不整脈を再発と定義した。年齢およびCHADS2スコアにかかわらず、AF発症または診断からカテーテルアブレーション治療実施までの期間が短くなるほど初回治療後の洞調律維持率が上昇した。AFは進行性疾患であり、AFの発症および診断から、抗凝固薬と効果の不確定な抗不整脈薬のみで漫然と経過観察するのではなく、できるだけ早期にカテーテルアブレーションを実施するため、プライマリケア医の早い判断で施行可能な施設に紹介することが重要であると考えられた。(著者抄録)

  • A Multivariable Regression Model-based Nomogram for Estimating the Overall Survival of Patients Previously Treated With Nivolumab for Advanced Non-small-cell Lung Cancer.

    Tamiya A, Tamiya M, Go H, Inoue T, Kunimasa K, Nakahama K, Taniguchi Y, Shiroyama T, Isa SI, Nishino K, Kumagai T, Suzuki H, Hirashima T, Atagi S, Shintani A, Imamura F

    Anticancer research   40 ( 8 )   4229 - 4236   2020.08( ISSN:0250-7005

  • Hematological Abnormalities and Malnutrition Mediate Pathway between Cancer and Outcomes in Ischemic Stroke Patients.

    Gon Y, Kabata D, Kawano T, Kanki H, Todo K, Sasaki T, Shintani A, Mochizuki H

    Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association   29 ( 8 )   104943   2020.08( ISSN:1052-3057

  • Impact of Pancreas Transplantation on the Patient Survival-An Analysis of the Japanese Pancreas Transplants Registry.

    Ito T, Kenmochi T, Aida N, Matsushima H, Kurihara K, Ishihara T, Shintani A, Asaoka T, Ito T

    Journal of clinical medicine   9 ( 7 )   1 - 15   2020.07( ISSN:2077-0383

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  • 診察時間の長さが慢性腰痛患者の満足度に及ぼす影響 日本で行われた全国多施設共同研究(Impact of Consultation Length on Satisfaction in Patients with Chronic Low Back Pain: A Nationwide Multicenter Study in Japan)

    Miyakoshi Naohisa, Kudo Daisuke, Matsuyama Yukihiro, Yamashita Toshihiko, Kawakami Mamoru, Takahashi Kazuhisa, Yoshida Munehito, Kaito Takashi, Imagama Shiro, Ohtori Seiji, Taguchi Toshihiko, Haro Hirotaka, Taneichi Hiroshi, Yamazaki Masashi, Inoue Gen, Nishida Kotaro, Yamada Hiroshi, Kabata Daijiro, Shintani Ayumi, Iwasaki Motoki, Ito Manabu, Murakami Hideki, Yonenobu Kazuo, Takura Tomoyuki, Mochida Joji

    Spine Surgery and Related Research   4 ( 3 )   208 - 215   2020.07

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    日本脊椎脊髄病学会の行う多施設共同研究に参加した28施設で治療を受けた慢性腰痛患者427例(男性179例、女性248例、年齢20~85歳)を対象に、診察時間が患者の満足度および転帰に及ぼす影響について検討した。満足度は主観的満足度スコア、EQ-5D(EuroQol 5 Dimension)、JOAスコア、ローランド・モリス機能障害質問票、JOA腰痛評価質問票(JOABPEQ)、VAS、SF-8(Medical Outcomes Survey Short Form-8)を用いて評価した。また整形外科患者に対する精神医学的問題評価のための簡易質問表(BS-POP)の医師用と患者用を使用して診察時間の影響を評価した。多変量非線形回帰分析の結果、診察時間とVASは有意に相関したが、他の評価項目との相関は有意でなかった。ベースライン時のBS-POPスコアが最も高い患者群で診察時間は満足度と有意に相関した。医師用と患者用のいずれを用いても上記の相関は有意で、満足度に関する診察時間の変曲点はそれぞれ15.1分と7.6分であった。以上より、診察時間は特に精神疾患を有する慢性腰痛患者における満足度に影響することが示唆された。

  • 入門講座 医療統計ことはじめ・3 介入研究のデザインとデータ解析

    新谷 歩

    総合リハビリテーション   48 ( 6 )   557 - 562   2020.06( ISSN:03869822

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  • 入門講座 医療統計ことはじめ・2 観察研究のデザインとデータ解析-多変量解析と傾向スコア

    新谷 歩

    総合リハビリテーション   48 ( 5 )   465 - 470   2020.05( ISSN:03869822

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  • 心房性機能性僧帽弁・三尖弁閉鎖不全症に対する弁形成術後の中期成績(Mid-term results of valve repairs for atrial functional mitral and tricuspid regurgitations)

    Takahashi Yosuke, Abe Yukio, Murakami Takashi, Fujii Hiromichi, Morisaki Akimasa, Nishimura Shinsuke, Sakon Yoshito, Ito Kazato, Shintani Ayumi, Shibata Toshihiko

    General Thoracic and Cardiovascular Surgery   68 ( 5 )   467 - 476   2020.05( ISSN:1863-6705

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    心房細動を有する心房性機能性僧帽弁・三尖弁閉鎖不全症に対する弁形成術後の中期成績について検討した。慢性心不全を呈し左室駆出率は保持され、中等度機能性僧帽弁閉鎖不全、軽度機能性三尖弁閉鎖不全を有する45例(男性24例、女性21例、中央値72歳)を対象とした。経過観察期間中央値は932日であった。NYHA機能クラスは術前と比較して術後に著明に改善が得られ、術後の心血管イベントの発症は10例で、弁関連非死亡率は1年後が98%、3年後が95%、5年後が95%であった。術後の弁関連死亡率と再入院の有意な予測因子として術前の左房容積指数(LAVI)が抽出され、術後心血管イベント発症の有意な予測因子として術前の駆出率、三尖弁閉鎖不全グレード、LAVIが示された。術後の脳血管塞栓と再手術を示す術前予測因子としてのLAVIのカットオフ値を求めたところ142mL/m2と算出され、感度は67%、特異度は90%、AUC 0.791という数値が得られた。術前にLAVI 142mL/m2以上を示していた患者では術後の脳血管塞栓の発症率と再手術の施行率が有意に高くなっていた。僧帽弁と三尖弁の弁形成術により閉鎖不全症状と心不全症状の改善が得られることが示され、術後心血管イベントのリスク因子として術前の左房サイズは重要であると考えられた。

  • 腎移植レシピエントのフレイルは腎移植前透析期間と関連する 日本の単一施設横断研究(Frailty is associated with dialysis duration before transplantation in kidney transplant recipients: A Japanese single-center cross-sectional study)

    Kosoku Akihiro, Uchida Junji, Iwai Tomoaki, Shimada Hisao, Kabei Kazuya, Nishide Shunji, Maeda Keiko, Kabata Daijiro, Shintani Ayumi, Nakatani Tatsuya

    International Journal of Urology   27 ( 5 )   408 - 414   2020.05( ISSN:0919-8172

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    腎移植患者205名(男性117名、女性88名、年齢中央値55歳)を対象とした単一施設横断研究を行い、フレイルの有病率、ならびに基本チェックリストに基づくフレイルと移植前透析期間および移植後期間との関係を調べた。基本チェックリストの全スコアと移植後期間および移植前透析期間との関連を調べるため、多変量比例オッズロジスティック回帰モデルを用いて、年齢、性別、BMI、推算糸球体濾過率、血清アルブミン値で調整した。その結果、有病率はフレイルが11.2%、プレフレイルが26.8%、ロバストが62.0%であった。移植前透析期間はフレイルと関連していたが、移植後期間はフレイルとは関連していなかった。これらの結果から、腎移植患者におけるフレイルの有病率は約11%であり、移植前透析期間と関連することが示唆された。

  • 入門講座 医療統計ことはじめ・1【新連載】 疫学研究デザインと記述研究に用いられる統計解析-単変量解析

    新谷 歩

    総合リハビリテーション   48 ( 4 )   355 - 361   2020.04( ISSN:03869822

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  • 生活習慣病高リスク者の受診を促進するための日本の治験 看護師主導の在宅基盤生活習慣病予防プログラム(Japan Trial in High-Risk Individuals to Enhance Their Referral to Physicians(J-HARP): A Nurse-Led, Community-Based Prevention Program of Lifestyle-Related Disease)

    Noguchi Midori, Kojima Sumi, Sairenchi Toshimi, Kinuta Minako, Yamakawa Miyae, Nishizawa Hitoshi, Takahara Mitsuyoshi, Imano Hironori, Kitamura Akihiko, Yoshida Toshiko, Shintani Ayumi, Saito Isao, Yokoyama Tetsuji, Shimomura Iichiro, Iso Hiroyasu, J-HARP Research Group

    Journal of Epidemiology   30 ( 3-4 )   194 - 199   2020.04( ISSN:0917-5040

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    <Highlight>●未治療の重症化ハイリスク者を対象に、「受療行動促進モデルを用いた保健指導」による受療促進効果を検証するため、全国43自治体を対象としたクラスターランダム化比較試験を実施した。●一般的な保健指導と比較した「受療行動促進モデルを用いた保健指導」の介入効果を検証するための研究データの収集が完了した。(著者抄録)

  • Frailty is associated with dialysis duration before transplantation in kidney transplant recipients: A Japanese single-center cross-sectional study. Reviewed

    Kosoku A, Uchida J, Iwai T, Shimada H, Kabei K, Nishide S, Maeda K, Kabata D, Shintani A, Nakatani T

    International journal of urology : official journal of the Japanese Urological Association   2020.03( ISSN:0919-8172

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    DOI: 10.1111/iju.14208

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  • ポリニューロパチー患者における糖尿病性ポリニューロパチー関連感覚症状・徴候の関連因子 非線形モデルを用いた日本国内における横断研究(JDDM 52)(Factors associated with diabetic polyneuropathy-related sensory symptoms and signs in patients with polyneuropathy: A cross-sectional Japanese study(JDDM 52) using a non-linear model)

    Yokoyama Hiroki, Tsuji Toshinaga, Hayashi Shinji, Kabata Daijiro, Shintani Ayumi

    Journal of Diabetes Investigation   11 ( 2 )   450 - 457   2020.03( ISSN:2040-1116

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    日本人糖尿病性ポリニューロパチー(DPN)患者におけるDPN関連の感覚症状/徴候の有症率ならびにその関連因子を評価した。日本国内17施設で集積された2型糖尿病患者の全国横断調査データベースから9914例を抽出した。このうち2745例がDPNを有し、1689例(DPN患者の61.5%)がDPN関連感覚症状/徴候を有していた。ロジスティック回帰モデルを用いた解析において、DPN関連感覚症状/徴候と現在の喫煙(オッズ比2.04)、過去の喫煙(同1.64)、性別(男性:同0.56)、過去の飲酒(同2.02)の間に有意な相関を認めた。非線形回帰モデルを用いた解析において、DPN関連感覚症状/徴候はより高い収縮期血圧、より長い糖尿病罹患期間、より低い年齢と有意な相関を示した。収縮期血圧の上昇に伴い、オッズの対数は約130mmHgまで増加し、その後プラトーに達した。喫煙、飲酒、収縮期血圧といった修正可能因子がDPN関連感覚症状/徴候に関連することが示された。

  • Impact of background factors on outcomes of pharmacological therapy for chronic low back pain: A nationwide multicenter prospective study. Reviewed

    Imagama S, Murakami H, Kaito T, Matsuyama Y, Yamashita T, Kawakami M, Takahashi K, Yoshida M, Ohtori S, Taguchi T, Haro H, Taneichi H, Yamazaki M, Inoue G, Nishida K, Yamada H, Kabata D, Shintani A, Iwasaki M, Ito M, Miyakoshi N, Yonenobu K, Takura T, Mochida J, Project Committee of the Japanese Society for Spine Surgery and Related Research (JSSR).

    Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association   2020.02( ISSN:0949-2658

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    DOI: 10.1016/j.jos.2020.02.003

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  • Selective plasma exchange in ABO-incompatible kidney transplantation: comparison of substitution with albumin and partial substitution with fresh frozen plasma. Reviewed

    Hanaoka A, Naganuma T, Kabata D, Takemoto Y, Uchida J, Nakatani T, Shintani A

    Scientific reports   10 ( 1 )   1434   2020.01

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41598-020-58436-2

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  • Impact of Consultation Length on Satisfaction in Patients With Chronic Low Back Pain: A Nationwide Multicenter Study in Japan Reviewed

    Miyakoshi Naohisa, Ohtori Seiji, Taguchi Toshihiko, Haro Hirotaka, Taneichi Hiroshi, Yamazaki Masashi, Inoue Gen, Nishida Kotaro, Yamada Hiroshi, Kabata Daijiro, Shintani Ayumi, Kudo Daisuke, Iwasaki Motoki, Ito Manabu, Murakami Hideki, Yonenobu Kazuo, Takura Tomoyuki, Mochida Joji, Matsuyama Yukihiro, Yamashita Toshihiko, Kawakami Mamoru, Takahashi Kazuhisa, Yoshida Munehito, Kaito Takashi, Imagama Shiro

    一般社団法人 日本脊椎脊髄病学会 Spine Surgery and Related Research   2020

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    <p><b>Introduction: </b>Chronic low back pain (CLBP) is a major health burden worldwide and requires patient satisfaction with treatment. Consultation length can be an important factor in patient satisfaction, but few studies have investigated the impact of consultation length on satisfaction in patients with CLBP. This study tried to elucidate the impact of consultation length on clinical outcomes in patients with CLBP.</p><p><b>Methods: </b>This study is part of an analysis using the database of the nationwide, multicenter cohort for CLBP performed by the Project Committee of the Japanese Society for Spine Surgery and Related Research. A total of 427 patients aged 20–85 years (median age, 73.0 years; female, 58.6%) with CLBP were prospectively followed-up monthly for 6 months. Multivariable nonlinear regression analyses were performed to assess the effect of consultation length on outcome measures including subjective satisfaction score, EuroQol 5-dimension, Japanese Orthopaedic Association (JOA) score, Roland–Morris Disability Questionnaire, JOA Back Pain Evaluation Questionnaire, visual analog scale (VAS) and Medical Outcome Survey short-form 8-item health survey that evaluated at the next phase. Furthermore, we assessed whether the effect of consultation length on patient satisfaction was modified by the baseline Brief Scale for Psychiatric Problems in Orthopaedic Patients (BS-POP) score for patient and physician versions.</p><p><b>Results: </b>VAS for CLBP was the only score that correlated significantly with consultation length (P = 0.018). Satisfaction score showed a significant positive correlation with consultation length in patients with the highest baseline BS-POP scores (P < 0.2). Moreover, consultation lengths more than 7.6 min and 15.1 min offered increase of satisfaction if patients show the highest BS-POP scores on patient and physician versions, respectively.</p><p><b>Conclusions:</b> These findings suggest that a sufficiently long consultation is an important factor for subjective satisfaction in the patients with CLBP, particularly in patients with psychological problems.</p>

    DOI: 10.22603/ssrr.2019-0111

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  • Time Course Changes in Urinary Angiotensinogen and Circulating N-Terminal Pro-B-Type Natriuretic Peptide in Patients Hospitalized with Acute Heart Failure

    Yokoyama Shota, Kawakami Ryo, Tobiume Atsushi, Onishi Keisuke, Fujita Takuro, Ozaki Taro, Miyake Yuichi, Ishizawa Makoto, Noma Takahisa, Shintani Ayumi, Kuroda Yasuhiro, Minamino Tetsuo

    Internal Medicine   59 ( 22 )   2839 - 2847   2020( ISSN:0918-2918

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    <p><b>Objective </b>Home care is important in patients with heart failure (HF) in order to maintain their quality of life. A biomarker that can be measured noninvasively is needed to optimize the home care of patients with HF. Urinary angiotensinogen (uAGT) is an indicator of the intrarenal renin-angiotensin system activity, which may be augmented in HF. We hypothesized that uAGT might be a urinary biomarker in HF. </p><p><b>Methods </b>We measured uAGT by an enzyme-linked immunosorbent assay and uAGT normalized by urinary creatinine (uCr)-designated uAGT/uCr-at admission and discharge in 45 patients hospitalized for HF. </p><p><b>Results </b>We found that both uAGT/uCr [median (interquartile range): 65.5 (17.1-127.7) μg/g Cr at admission; 12.1 (6.0-37.0) μg/g Cr at discharge; p<0.01] and N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels [5,422 (2,280-9,907) pg/mL at admission; 903 (510-1,729) pg/mL at discharge; p<0.01] significantly decreased between admission and discharge along with an improvement in patient's clinical status [New York Heart Association scores: 3 (3-4) at admission; 1 (1-1) at discharge; p<0.01]. The generalized least squares model revealed that the time course changes in uAGT/uCr also correlated with those in NT-proBNP levels between admission and readmission in five patients readmitted for HF. </p><p><b>Conclusion </b>The results indicated that the time course changes in uAGT/uCr correlated with those in the NT-proBNP levels in patients with HF who showed a clinical improvement. Further investigation and development of a kit for the rapid measurement of uAGT are needed to evaluate the clinical utility of uAGT as a biomarker in HF. </p>

    DOI: 10.2169/internalmedicine.5212-20

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    CiNii Article

  • Type and Size of Implanted Bioprosthetic Valve Rather Than Intraoperative Peak Transprosthetic Valvular Velocity Predict Postoperative Midterm Prosthesis-Patient Mismatch in Patients Undergoing Surgical Aortic Valve Replacement Reviewed

    Minami Kimito, Kabata Daijiro, Shintani Ayumi, Matsumoto Yorihiko, Tadokoro Naoki, Fujita Tomoyuki, Yoshitani Kenji, Ohnishi Yoshihiko

    JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA   33 ( 12 )   3264 - 3270   2019.12( ISSN:1053-0770

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    DOI: 10.1053/j.jvca.2019.06.002

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  • Natural kinetics of blood cells following major burn: Impact of early decreases in white blood cells and platelets as prognostic markers of mortality Reviewed

    Osuka Akinori, Ishihara Takuma, Shimizu Kentaro, Shintani Ayumi, Ogura Hiroshi, Ueyama Masahi

    BURNS   45 ( 8 )   1901 - 1907   2019.12( ISSN:0305-4179

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    DOI: 10.1016/j.burns.2019.07.014

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  • Effectiveness of music therapy for alleviating pain during haemodialysis access cannulation for patients undergoing haemodialysis: a multi-facility, single-blind, randomised controlled trial Reviewed

    Kishida Masatsugu, Yamada Yosuke, Inayama Emi, Kitamura Mineaki, Nishino Tomoya, Ota Keiko, Shintani Ayumi, Ikenoue Tatsuyoshi

    TRIALS   20 ( 1 )   631   2019.11

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s13063-019-3773-x

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  • Identifying Sepsis Populations Benefitting from Anticoagulant Therapy: A Prospective Cohort Study Incorporating a Restricted Cubic Spline Regression Model Reviewed

    Yamakawa Kazuma, Gando Satoshi, Ogura Hiroshi, Umemura Yutaka, Kabata Daijiro, Shintani Ayumi, Shiraishi Atsushi, Saitoh Daizoh, Fujishima Seitato, Mayumi Toshihiko, Kushimoto Shigeki, Abe Toshikazu, Shiino Yasukazu, Nakada Taka-aki, Tarui Takehiko, Hifumi Toru, Otomo Yasuhiro, Okamoto Kohji, Kotani Joji, Sakamoto Yuichiro, Sasaki Junichi, Shiraishi Shin-ichiro, Takuma Kiyotsugu, Tsuruta Ryosuke, Hagiwara Akiyoshi, Masuno Tomohiko, Takeyama Naoshi, Yamashita Norio, Ikeda Hiroto, Ueyama Masashi, Fujimi Satoshi, Tasaki Osamu, Mizobata Yasumitsu, Funakoshi Hiraku, Okuyama Toshiro, Yamashita Iwao, Kanai Toshio, Yamada Yasuo, Aibiki Mayuki, Sato Keiji, Yamashita Susumu, Yoshida Kenichi, Kasaoka Shunji, Kon Akihide, Rinka Hiroshi, Kato Hiroshi, Okudera Hiroshi, Narimatsu Eichi, Fujiwara Toshifumi, Sugita Manabu, Shichinohe Yasuo, Nakae Hajime, Iiduka Ryouji, Nakamura Mitsunobu, Murata Yuji, Sato Yoshitake, Ishikura Hiroyasu, Myojo Yasuhiro, Tsujita Yasuyuki, Kinoshita Kosaku, Yamaguchi Hiroyuki, Sakurai Toshihiro, Miyatake Satoru, Saotome Takao, Yasuda Susumu, Fujishima Seitaro, Mizushima Yasuaki

    THROMBOSIS AND HAEMOSTASIS   119 ( 11 )   1740 - 1751   2019.11( ISSN:0340-6245

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1055/s-0039-1693740

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  • Reply to: The need for comprehensive NIRS-measurement from on-scene treatment to post-ROSC phase Reviewed

    Takegawa Ryosuke, Shiozaki Tadahiko, Ogawa Yoshihito, Hirose Tomoya, Mori Nobuto, Ohnishi Mitsuo, Shimazu Takeshi, Ishihara Takuma, Shintani Ayumi

    RESUSCITATION   144   193 - 194   2019.11( ISSN:0300-9572

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.resuscitation.2019.09.001

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  • Positive correlation between pancreatic volume and post-endoscopic retrograde cholangiopancreatography pancreatitis Reviewed

    Maruyama Hirotsugu, Shiba Masatsugu, Ishikawa-Kakiya Yuki, Kato Kunihiro, Ominami Masaki, Fukunaga Shusei, Otani Koji, Hosomi Shuhei, Tanaka Fumio, Kamata Noriko, Taira Koichi, Nagami Yasuaki, Yamagami Hirokazu, Tanigawa Tetsuya, Watanabe Toshio, Yamamoto Akira, Kabata Daijiro, Shintani Ayumi, Fujiwara Yasuhiro

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   2019.10( ISSN:0815-9319

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/jgh.14878

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  • Development of a Geriatric Prognostic Scoring System for Predicting Survival After Surgery for Elderly Patients With Gastrointestinal Cancer. Reviewed

    Yamasaki M, Maekawa Y, Sugimoto K, Mizushima T, Eguchi H, Ogihara T, Shintani A, Rakugi H, Mori M, Doki Y

    Annals of surgical oncology   26 ( 11 )   3644 - 3651   2019.10( ISSN:1068-9265

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1245/s10434-019-07687-z

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  • Translation and validation of the 8-item Contact Lens Dry Eye Questionnaire (CLDEQ-8) among Japanese soft contact lens wearers: The J-CLDEQ-8 Reviewed

    Koh Shizuka, Chalmers Robin, Kabata Daijiro, Shintani Ayumi, Nishida Kohji

    CONTACT LENS & ANTERIOR EYE   42 ( 5 )   533 - 539   2019.10( ISSN:1367-0484

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    DOI: 10.1016/j.clae.2019.03.002

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  • Nomogram Based on Multivariable Regression Model Estimates the Overall Survival of Nivolumab for Previously Treated Advanced NSCLC Reviewed

    Tamiya M., Tamiya A., Go H., Inoue T., Kimura M., Kunimasa K., Nakahama K., Taniguchi Y., Shiroyama T., Isa S., Nishino K., Kumagai T., Suzuki H., Atagi S., Hirashima T., Shintani A., Imamura F.

    JOURNAL OF THORACIC ONCOLOGY   14 ( 10 )   S465 - S465   2019.10( ISSN:1556-0864

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  • Mid-term results of valve repairs for atrial functional mitral and tricuspid regurgitations. Reviewed

    Takahashi Y, Abe Y, Takashi M, Fujii H, Morisaki A, Nishimura S, Sakon Y, Ito K, Shintani A, Shibata T

    General thoracic and cardiovascular surgery   2019.09( ISSN:1863-6705

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    DOI: 10.1007/s11748-019-01203-6

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  • Cost-effectiveness analysis of the pharmacological management of chronic low back pain with four leading drugs Reviewed

    Kaito Takashi, Matsuyama Yukihiro, Yamashita Toshihiko, Kawakami Mamoru, Takahashi Kazuhisa, Yoshida Munehito, Imagama Shiro, Ohtori Seiji, Taguchi Toshihiko, Haro Hirotaka, Taneichi Hiroshi, Yamazaki Masashi, Inoue Gen, Nishida Kotaro, Yamada Hiroshi, Kabata Daijiro, Shintani Ayumi, Iwasaki Motoki, Ito Manabu, Miyakoshi Naohisa, Murakami Hideki, Yonenobu Kazuo, Takura Tomoyuki, Mochida Joji

    JOURNAL OF ORTHOPAEDIC SCIENCE   24 ( 5 )   805 - 811   2019.09( ISSN:0949-2658

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.jos.2019.06.004

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  • Reply to: Comment on "Usefulness of cerebral rSO(2) monitoring during CPR to predict the probability of return of spontaneous circulation" Reviewed

    Takegawa Ryosuke, Shiozaki Tadahiko, Ogawa Yoshihito, Hirose Tomoya, Mori Nobuto, Ohnishi Mitsuo, Ishihara Takuma, Shintani Ayumi, Shimazu Takeshi

    RESUSCITATION   142   195 - 196   2019.09( ISSN:0300-9572

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    DOI: 10.1016/j.resuscitation.2019.06.288

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  • Quick risk assessment profile (qRAP) is a prediction model for post-traumatic venous thromboembolism Reviewed

    Tachino Jotaro, Yamamoto Kouji, Shimizu Kentaro, Shintani Ayumi, Kimura Akio, Ogura Hiroshi, Shimazu Takeshi

    INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED   50 ( 9 )   1540 - 1544   2019.09( ISSN:0020-1383

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    DOI: 10.1016/j.injury.2019.06.020

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  • Cost-effectiveness analysis of the pharmacological management of chronic low back pain with four leading drugs(和訳中) Reviewed

    Kaito Takashi, Matsuyama Yukihiro, Yamashita Toshihiko, Kawakami Mamoru, Takahashi Kazuhisa, Yoshida Munehito, Imagama Shiro, Ohtori Seiji, Taguchi Toshihiko, Haro Hirotaka, Taneichi Hiroshi, Yamazaki Masashi, Inoue Gen, Nishida Kotaro, Yamada Hiroshi, Kabata Daijiro, Shintani Ayumi, Iwasaki Motoki, Ito Manabu, Miyakoshi Naohisa, Murakami Hideki, Yonenobu Kazuo, Takura Tomoyuki, Mochida Joji, The Project Committee of the Japanese Society for Spine Surgery and Related Research(JSSR)

    (公社)日本整形外科学会 Journal of Orthopaedic Science   24 ( 5 )   805 - 811   2019.09( ISSN:0949-2658

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  • 平成30年度大阪府下慢性透析患者の実態調査 Reviewed

    長沼 俊秀, 武本 佳昭, 内田 潤次, 仲谷 達也, 加葉田 大志朗, 新谷 歩

    大阪透析研究会 大阪透析研究会会誌   37 ( 2 )   149 - 165   2019.09( ISSN:0912-6937

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    平成30年12月末現在の大阪府下の慢性透析患者、透析施設および従事者について実態調査を行った。透析施設数は平成29年度と比較して、5施設増加し307施設となった。透析患者数は前年度より若干減少し本年度は23,525人となった。透析療法のモダリティとしては血液透析(HD)患者が52.7%と過半数をしめたが、血液濾過透析(HDF)患者が44.2%と大幅に増加した。HDF療法の内訳ではI-HDFが38.7%をしめた。平成30年度の新規導入患者にしめる糖尿病を原疾患とする患者の割合は27.8%と本年度は増加した。患者全体にしめる糖尿病を原疾患とする患者の割合は38.9%と前年度に引き続き減少した。入院患者のしめる割合はHDが8.3%、PDが15.7%であった。総死亡者数は2,064人(粗死亡率8.8%)であり、死亡原因では感染症26.8%、循環器障害26.0%、悪性腫瘍5.9%、脳血管障害5.4%が上位をしめた。二次性副甲状腺機能亢進症の治療法において炭酸ランタン、シナカルセトが減少し、静注用ビタミンD使用が増加した。腎性貧血に対するESA製剤の使用状況はエポエチンが増加し、エポエチンベータペゴル使用が減少した。透析液のエンドトキシン測定頻度は月1回以上の施設が最多であった。血液透析患者100人あたりの従事者数は医師5.3人、看護師12.5人、臨床工学士7.6人、栄養士1.5人、ケースワーカー1.1人、その他4.0人と総計32.0人で前年度に比較して減少した。(著者抄録)

  • New insight into tricuspid valve anatomy from 100 hearts to reappraise annuloplasty methodology(和訳中) Reviewed

    Sakon Yoshito, Murakami Takashi, Fujii Hiromichi, Takahashi Yosuke, Morisaki Akimasa, Yamane Kokoro, Ohsawa Masahiko, Shintani Ayumi, Seki Toshiko, Shibata Toshihiko

    シュプリンガー・ジャパン(株) General Thoracic and Cardiovascular Surgery   67 ( 9 )   758 - 764   2019.09( ISSN:1863-6705

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  • New insight into tricuspid valve anatomy from 100 hearts to reappraise annuloplasty methodology Reviewed

    Sakon Yoshito, Murakami Takashi, Fujii Hiromichi, Takahashi Yosuke, Morisaki Akimasa, Yamane Kokoro, Ohsawa Masahiko, Shintani Ayumi, Seki Toshiko, Shibata Toshihiko

    GENERAL THORACIC AND CARDIOVASCULAR SURGERY   67 ( 9 )   758 - 764   2019.09( ISSN:1863-6705

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s11748-019-01092-9

    PubMed

  • Cost-effectiveness analysis of the pharmacological management of chronic low back pain with four leading drugs(和訳中) Reviewed

    Kaito Takashi, Matsuyama Yukihiro, Yamashita Toshihiko, Kawakami Mamoru, Takahashi Kazuhisa, Yoshida Munehito, Imagama Shiro, Ohtori Seiji, Taguchi Toshihiko, Haro Hirotaka, Taneichi Hiroshi, Yamazaki Masashi, Inoue Gen, Nishida Kotaro, Yamada Hiroshi, Kabata Daijiro, Shintani Ayumi, Iwasaki Motoki, Ito Manabu, Miyakoshi Naohisa, Murakami Hideki, Yonenobu Kazuo, Takura Tomoyuki, Mochida Joji, The Project Committee of, the, Japanese, Society for, Spine Surgery, Related Research(JSSR

    (公社)日本整形外科学会 Journal of Orthopaedic Science   24 ( 5 )   805 - 811   2019.09( ISSN:0949-2658

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    Publishing type:Research paper (scientific journal)  

  • 平成30年度大阪府下慢性透析患者の実態調査 Reviewed

    長沼 俊秀, 武本 佳昭, 内田 潤次, 仲谷 達也, 加葉田 大志朗, 新谷 歩

    大阪透析研究会 大阪透析研究会会誌   37 ( 2 )   149 - 165   2019.09( ISSN:0912-6937

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    Publishing type:Research paper (scientific journal)  

    平成30年12月末現在の大阪府下の慢性透析患者、透析施設および従事者について実態調査を行った。透析施設数は平成29年度と比較して、5施設増加し307施設となった。透析患者数は前年度より若干減少し本年度は23,525人となった。透析療法のモダリティとしては血液透析(HD)患者が52.7%と過半数をしめたが、血液濾過透析(HDF)患者が44.2%と大幅に増加した。HDF療法の内訳ではI-HDFが38.7%をしめた。平成30年度の新規導入患者にしめる糖尿病を原疾患とする患者の割合は27.8%と本年度は増加した。患者全体にしめる糖尿病を原疾患とする患者の割合は38.9%と前年度に引き続き減少した。入院患者のしめる割合はHDが8.3%、PDが15.7%であった。総死亡者数は2,064人(粗死亡率8.8%)であり、死亡原因では感染症26.8%、循環器障害26.0%、悪性腫瘍5.9%、脳血管障害5.4%が上位をしめた。二次性副甲状腺機能亢進症の治療法において炭酸ランタン、シナカルセトが減少し、静注用ビタミンD使用が増加した。腎性貧血に対するESA製剤の使用状況はエポエチンが増加し、エポエチンベータペゴル使用が減少した。透析液のエンドトキシン測定頻度は月1回以上の施設が最多であった。血液透析患者100人あたりの従事者数は医師5.3人、看護師12.5人、臨床工学士7.6人、栄養士1.5人、ケースワーカー1.1人、その他4.0人と総計32.0人で前年度に比較して減少した。(著者抄録)

  • 誌上シンポジウム 整形外科治療の費用対効果 費用対効果の評価方法の基本

    加葉田 大志朗, 新谷 歩

    臨床整形外科   54 ( 8 )   767 - 770   2019.08( ISSN:05570433

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  • Prediction model for cardiovascular events or all-cause mortality in incident dialysis patients Reviewed

    Inaguma Daijo, Morii Daichi, Kabata Daijiro, Yoshida Hiroyuki, Tanaka Akihito, Koshi-Ito Eri, Takahashi Kazuo, Hayashi Hiroki, Koide Shigehisa, Tsuboi Naotake, Hasegawa Midori, Shintani Ayumi, Yuzawa Yukio

    PLOS ONE   14 ( 8 )   e0221352   2019.08( ISSN:1932-6203

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1371/journal.pone.0221352

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  • Disentangling Associations Between Serum Muscle Biomarkers and Sarcopenia in the Presence of Pain and Inflammation Among Patients With Osteoarthritis: The SPSS-OK Study. Reviewed

    Kurita N, Kamitani T, Wada O, Shintani A, Mizuno K

    Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases   2019.08( ISSN:1076-1608

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1097/RHU.0000000000001156

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  • Factors associated with diabetic polyneuropathy-related sensory symptoms and signs in patients with polyneuropathy: A cross-sectional Japanese study (JDDM 52) using a non-linear model Reviewed

    Yokoyama Hiroki, Tsuji Toshinaga, Hayashi Shinji, Kabata Daijiro, Shintani Ayumi

    JOURNAL OF DIABETES INVESTIGATION   2019.08( ISSN:2040-1116

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/jdi.13117

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  • Safety of tooth extraction in patients receiving direct oral anticoagulant treatment versus warfarin: a prospective observation study Reviewed

    Yoshikawa H., Yoshida M., Yasaka M., Yoshida H., Murasato Y., Fukunaga D., Shintani A., Okada Y.

    INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY   48 ( 8 )   1102 - 1108   2019.08( ISSN:0901-5027

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.ijom.2019.01.013

  • 臨床研究データの集積と活用法

    新谷 歩

    日本看護研究学会雑誌   42 ( 3 )   3_346 - 3_346   2019.07( ISSN:21883599

  • Thyroid blood flow in inferior thyroid artery as predictor for increase in levothyroxine dosage during pregnancy in women with Hashimoto's thyroiditis - a retrospective study Reviewed

    Kurajoh Masafumi, Yamasaki Akiyo, Nagasaki Toshiki, Nagata Yuki, Yamada Shinsuke, Imanishi Yasuo, Emoto Masanori, Takahashi Kanae, Yamamoto Kouji, Shintani Ayumi, Inaba Masaaki

    BMC PREGNANCY AND CHILDBIRTH   19 ( 1 )   232   2019.07( ISSN:1471-2393

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s12884-019-2389-1

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  • Translation and Validation of the 8-Item Contact Lens Dry Eye Questionnaire (CLDEQ-8) among Japanese Soft Contact Lens Wearers: the J-CLDEQ-8 Reviewed

    Koh Shizuka, Chalmers Robin, Kabata Daijiro, Shintani Ayumi, Nishida Kohji

    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE   60 ( 9 )   2019.07( ISSN:0146-0404

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  • Translation and Validation of the 8-Item Contact Lens Dry Eye Questionnaire (CLDEQ-8) among Japanese Soft Contact Lens Wearers: the J-CLDEQ-8 Reviewed

    Koh Shizuka, Chalmers Robin, Kabata Daijiro, Shintani Ayumi, Nishida Kohji

    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE   60 ( 9 )   2019.07( ISSN:0146-0404

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  • A Scoring System with High-Resolution Computed Tomography to Predict Drug-Associated Acute Respiratory Distress Syndrome: Development and Internal Validation Reviewed

    Anan Keisuke, Ichikado Kazuya, Ishihara Takuma, Shintani Ayumi, Kawamura Kodai, Suga Moritaka, Sakagami Takuro

    SCIENTIFIC REPORTS   9 ( 1 )   8601   2019.06( ISSN:2045-2322

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41598-019-45063-9

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  • Serum albumin as a risk factor for death in patients with prolonged sepsis: An observational study Reviewed

    Takegawa Ryosuke, Kabata Daijiro, Shimizu Kentaro, Hisano Saya, Ogura Hiroshi, Shintani Ayumi, Shimazu Takeshi

    JOURNAL OF CRITICAL CARE   51   139 - 144   2019.06( ISSN:0883-9441

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.jcrc.2019.02.004

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  • Usefulness of cerebral rSO(2) monitoring during CPR to predict the probability of return of spontaneous circulation Reviewed

    Takegawa Ryosuke, Shiozaki Tadahiko, Ogawa Yoshihito, Hirose Tomoya, Mori Nobuto, Ohnishi Mitsuo, Ishihara Takuma, Shintani Ayumi, Shimazu Takeshi

    RESUSCITATION   139   201 - 207   2019.06( ISSN:0300-9572

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.resuscitation.2019.04.015

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  • Lack of posterior occlusal support predicts the reduction in walking speed in 80-year-old Japanese adults: A 3-year prospective cohort study with propensity score analysis by the SONIC Study Group Reviewed

    Hatta Kodai, Ikebe Kazunori, Mihara Yusuke, Gondo Yasuyuki, Kamide Kei, Masui Yukie, Sugimoto Ken, Matsuda Ken-ichi, Fukutake Motoyoshi, Kabayama Mai, Shintani Ayumi, Ishizaki Tatsuro, Arai Yasumichi, Rakugi Hiromi, Maeda Yoshinobu

    GERODONTOLOGY   36 ( 2 )   156 - 162   2019.06( ISSN:0734-0664

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/ger.12393

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  • New insight into tricuspid valve anatomy from 100 hearts to reappraise annuloplasty methodology (April,10.1007/s11748-019-01092-9, 2019) Reviewed

    Sakon Yoshito, Murakami Takashi, Fujii Hiromichi, Takahashi Yosuke, Morisaki Akimasa, Yamane Kokoro, Ohsawa Masahiko, Shintani Ayumi, Seki Toshiko, Shibata Toshihiko

    GENERAL THORACIC AND CARDIOVASCULAR SURGERY   67 ( 6 )   572 - 572   2019.06( ISSN:1863-6705

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s11748-019-01114-6

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  • Nomogram based on multivariable regression model estimates the overall survival of patients with nivolumab who were previously treated for advanced non-small cell lung cancer. Reviewed

    Tamiya Motohiro, Tamiya Akihiro, Go Hirofumi, Inoue Takako, Kimura Madoka, Kunimasa Kei, Nakahama Kenji, Taniguchi Yoshihiko, Shiroyama Takayuki, Isa Shun-Ichi, Nishino Kazumi, Kumagai Toru, Suzuki Hidekazu, Hirashima Tomonori, Atagi Shinji, Shintani Ayumi, Imamura Fumio

    JOURNAL OF CLINICAL ONCOLOGY   37 ( 15 )   2019.05( ISSN:0732-183X

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    Publishing type:Research paper (scientific journal)  

  • Nomogram based on multivariable regression model estimates the overall survival of patients with nivolumab who were previously treated for advanced non-small cell lung cancer. Reviewed

    Tamiya Motohiro, Tamiya Akihiro, Go Hirofumi, Inoue Takako, Kimura Madoka, Kunimasa Kei, Nakahama Kenji, Taniguchi Yoshihiko, Shiroyama Takayuki, Isa Shun-Ichi, Nishino Kazumi, Kumagai Toru, Suzuki Hidekazu, Hirashima Tomonori, Atagi Shinji, Shintani Ayumi, Imamura Fumio

    JOURNAL OF CLINICAL ONCOLOGY   37 ( 15 )   2019.05( ISSN:0732-183X

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  • ISSLS PRIZE IN CLINICAL SCIENCE 2019: clinical importance of trunk muscle mass for low back pain, spinal balance, and quality of lifea multicenter cross-sectional study Reviewed

    Hori Yusuke, Hoshino Masatoshi, Inage Kazuhide, Miyagi Masayuki, Takahashi Shinji, Ohyama Shoichiro, Suzuki Akinobu, Tsujio Tadao, Terai Hidetomi, Dohzono Sho, Sasaoka Ryuichi, Toyoda Hiromitsu, Kato Minori, Matsumura Akira, Namikawa Takashi, Seki Masahiko, Yamada Kentaro, Habibi Hasibullah, Salimi Hamidullah, Yamashita Masaomi, Yamauchi Tomonori, Furuya Takeo, Orita Sumihisa, Maki Satoshi, Shiga Yasuhiro, Inoue Masahiro, Inoue Gen, Fujimaki Hisako, Murata Kosuke, Kawakubo Ayumu, Kabata Daijiro, Shintani Ayumi, Ohtori Seiji, Takaso Masashi, Nakamura Hiroaki

    EUROPEAN SPINE JOURNAL   28 ( 5 )   914 - 921   2019.05( ISSN:0940-6719

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00586-019-05904-7

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  • Long-term Chronological Changes in Very Asymmetric Keratoconus Reviewed

    Koh Shizuka, Inoue Ryota, Maeda Naoyuki, Kabata Daijiro, Shintani Ayumi, Jhanji Vishal, Klyce Stephen D., Maruyama Kazuichi, Nishida Kohji

    CORNEA   38 ( 5 )   605 - 611   2019.05( ISSN:0277-3740

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1097/ICO.0000000000001890

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  • Study Profile: Japan Trial in High-risk Individuals to Accelerate their Referral to Physicians (J-HARP) - a Nurse-led, Community-based Prevention Program of Lifestyle-related Disease. Reviewed

    Noguchi M, Kojima S, Sairenchi T, Kinuta M, Yamakawa M, Nishizawa H, Takahara M, Imano H, Kitamura A, Yoshida T, Shintani A, Saito I, Yokoyama T, Shimomura I, Iso H

    日本疫学会 Journal of epidemiology   2019.04( ISSN:0917-5040

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    <p><b>Background:</b> It is uncertain whether health counselling after community-based health checkups for high-risk individuals of lifestyle-related disease enhances their referral to physicians.</p><p><b>Methods:</b> We performed a clustered randomized controlled trial of untreated high-risk individuals aged 40 to 74 years who were screened from the annual health checkup in 2014 and 2015 under the national health insurance in 43 municipalities around Japan, assigning 21 intervention and 22 usual care municipalities. The high-risk conditions were severe forms of hypertension, diabetes, dyslipidemia (for men), and proteinuria. For the intervention group, the theory-based health counselling was performed to enhance referrals to physicians, while each municipality performed its own standard counselling for the usual care group. Data on clinical visits and risk factors were collected systematically and anonymously from the databases of health insurance qualification, health insurance claims, and annual health checkups. Hypotheses are that the cumulative proportion of seeing physicians (clinical visits) is higher in the intervention than the usual care groups, and that those in the intervention group have lower cumulative incidence of composite outcomes associated with lifestyle-related diseases.</p><p><b>Results:</b> The numbers of subjects for the analyses were 8,977 in the intervention group and 6,733 in the usual care group. Among them, 6,758 had hypertension, 2,147 had diabetes, 2,861 had dyslipidemia, and 1,221 had proteinuria in the intervention group, with corresponding numbers of 4,833, 1,517, 2,262, and 845, respectively, in the usual care group. There were no material differences in mean levels and proportions of major cardiovascular risk factors between the two groups.</p><p><b>Conclusions:</b> We expect to provide scientific evidence on the effectiveness of health counselling.</p>

    DOI: 10.2188/jea.JE20180194

    PubMed

    CiNii Article

  • Crosstalk between tumor necrosis factor-alpha signaling and aryl hydrocarbon receptor signaling in nuclear factor -kappa B activation: A possible molecular mechanism underlying the reduced efficacy of TNF-inhibitors in rheumatoid arthritis by smoking Reviewed

    Nii Takuro, Kuzuya Kentaro, Kabata Daijiro, Matsui Toshihiro, Murata Atsuko, Ohya Takeshi, Matsuoka Hidetoshi, Shimizu Takashi, Oguro Eri, Okita Yasutaka, Udagawa Chikako, Yoshimura Maiko, Kudo-Tanaka Eriko, Teshigawara Satoru, Harada Yoshinori, Yoshida Yuji, Isoda Kentaro, Tsuji So-Ichiro, Ohshima Shiro, Hashimoto Jun, Shintani Ayumi, Takehana Yasuo, Tohma Shigeto, Saeki Yukihiko

    JOURNAL OF AUTOIMMUNITY   98   95 - 102   2019.03( ISSN:0896-8411

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    DOI: 10.1016/j.jaut.2018.12.004

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  • Statistical analysis of observational study

    KABATA Daijiro, SHINTANI Ayumi

    Journal of Japan Society of Pain Clinicians   26 ( 1 )   1 - 6   2019.02( ISSN:13404903

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    <p>In any observational study where an exposure of interest, such as pharmaceutical treatment, is not randomly assigned to subjects, a bias is often introduced in estimating the true effect of treatment. This is because patients who receive treatment usually have more severe medical conditions than those without treatment. Failure to control such inherent bias in patient characteristics when assessing for the true effect of treatment across comparison groups, may lead to confounding. The presence of confounding makes it difficult to evaluate the true treatment effect. In this paper, we will introduce statistical strategies which aim to remove the effects of confounding in observational studies.</p>

    DOI: 10.11321/jjspc.18-0017

    CiNii Article

  • Efficacy of selective plasma exchange as pre-Transplant apheresis in ABO-incompatible kidney transplantation

    Hanaoka A.

    Renal Replacement Therapy   5 ( 1 )   2019.02

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  • A Multicenter Retrospective Study of Elective Neck Dissection for T1-2N0M0 Tongue Squamous Cell Carcinoma: Analysis Using Propensity Score-Matching. Reviewed

    Otsuru M, Ota Y, Yanamoto S, Okura M, Umeda M, Kirita T, Kurita H, Ueda M, Komori T, Yamakawa N, Kamata T, Hasegawa T, Shibahara T, Ohiro Y, Yamashita Y, Noguchi K, Noguchi T, Karakida K, Naito H, Aikawa T, Yamashita T, Kabata D, Shintani A

    Annals of surgical oncology   26 ( 2 )   555 - 563   2019.02( ISSN:1068-9265

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1245/s10434-018-07089-7

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  • Impact of Computed Tomography Evaluation Before Colonoscopy for the Management of Colonic Diverticular Hemorrhage Reviewed

    Ichiba Toshihisa, Hara Masahiko, Miyahara Koji, Urashima Masaki, Shintani Ayumi, Naitou Hiroshi, Higashi Reiji

    JOURNAL OF CLINICAL GASTROENTEROLOGY   53 ( 2 )   E75 - E83   2019.02( ISSN:0192-0790

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    DOI: 10.1097/MCG.0000000000000988

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  • Parathyroid hormone and premature thymus ageing in patients with chronic kidney disease Reviewed

    Iio Kenichiro, Kabata Daijiro, Iio Rei, Imai Yosuke, Hatanaka Masaki, Omori Hiroki, Hoshida Yoshihiko, Saeki Yukihiko, Shintani Ayumi, Hamano Takayuki, Isaka Yoshitaka, Ando Yutaka

    SCIENTIFIC REPORTS   9 ( 1 )   813   2019.01( ISSN:2045-2322

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    DOI: 10.1038/s41598-018-37511-9

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  • Usefulness of serum biopterin as a predictive biomarker for childhood asthma control: A prospective cohort study Reviewed

    Kasuga Saki, Kabata Daijiro, Sakaguchi Tomoko, Kudoh Satoshi, Nishigaki Satsuki, Higa Yusuke, Fujikawa Shiori, Fujitani Hiroko, Shintani Ayumi, Hamazaki Takashi, Shintaku Haruo

    一般社団法人日本アレルギー学会 ALLERGOLOGY INTERNATIONAL   68 ( 1 )   96 - 100   2019.01( ISSN:1323-8930

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    <p><i>Background:</i> Pteridines are metabolites of tetrahydrobiopterin, which serves as co-enzyme of nitric oxide synthase. We sought to investigate the usefulness of pteridines as biomarkers for childhood asthma control.</p><p><i>Methods:</i> We conducted a single-center prospective cohort study involving 168 asthmatic children aged 4-17 years who visited the periodical asthma checkup program. Serum neopterin and biopterin levels were measured as pteridines at each visit along with measurement of FeNO, respiratory function tests, nasal eosinophil test, blood eosinophil count, and IgE level. We calculated coefficients for relation between pteridines and asthma control, which was assessed by questionnaires (JPAC: Japanese Pediatric Asthma Control Program).</p><p><i>Results:</i> A total of 168 participants aged 10.3 ± 3.39 years (mean ± SD) with asthma were recruited. The participants in this study contained 58 patients (34.5%) of complete-controlled based on JPAC, 132 patients (76.0%) of well-controlled group based on GINA. FeNO and serum neopterin level did not correlate with following period's JPAC scores. In contrast, serum biopterin level significantly correlated with following period's JPAC total score (Coefficients 0.398; 95% CI 0.164 to 0.632; <i>p</i> value 0.001) and frequency of wheezing during exercise (Coefficients 0.272; 95% CI 0.217 to 0.328; <i>p</i> value < 0.001).</p><p><i>Conclusions:</i> We found serum biopterin effected the following period's control status of asthmatic children, thus monitoring biopterin level will be a useful for management of asthma to adjust treatment.</p>

    DOI: 10.1016/j.alit.2018.08.012

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    CiNii Article

  • 小児喘息管理のための予測バイオマーカーとしての血清ビオプテリンの有用性 前向きコホート研究(Usefulness of serum biopterin as a predictive biomarker for childhood asthma control: A prospective cohort study) Reviewed

    Kasuga Saki, Kabata Daijiro, Sakaguchi Tomoko, Kudoh Satoshi, Nishigaki Satsuki, Higa Yusuke, Fujikawa Shiori, Fujitani Hiroko, Shintani Ayumi, Hamazaki Takashi, Shintaku Haruo

    (一社)日本アレルギー学会 Allergology International   68 ( 1 )   96 - 100   2019.01( ISSN:1323-8930

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    喘息児における、テトラヒドロビオプテリンの代謝物であるプテリジン類と喘息管理状態の関連性を単一施設前向きコホート研究により検討した。喘息児168例(男児96例、年齢4〜17歳)を対象に、プテリジン類として血清中のネオプテリンとビオプテリンを測定するとともに、呼気一酸化窒素濃度(FeNO)、呼吸機能、鼻好酸球、血中好酸球数、免疫グロブリンE値を測定した。またJapanese Pediatric Asthma Control Program(JPAC)質問票で評価した喘息管理とプテリジンとの関連を推定した。喘息管理状況は、JPACで「完全管理」に分類された症例は58例、Global Initiative for Asthma分類で「管理良好」とされた症例は132例であった。FeNOとネオプテリン値は経過観察期間のJPACスコアとは相関しなかったが、血清ビオプテリン値は経過観察期間のJPAC総スコアおよび運動中の喘鳴頻度とは有意な相関関係があった。血清ビオプテリンは、喘息児の経過観察期間の管理状態に影響しており、ビオプテリン値のモニタリングが喘息管理に有用であることが示唆された。

  • 小児喘息管理のための予測バイオマーカーとしての血清ビオプテリンの有用性 前向きコホート研究(Usefulness of serum biopterin as a predictive biomarker for childhood asthma control: A prospective cohort study) Reviewed

    Kasuga Saki, Kabata Daijiro, Sakaguchi Tomoko, Kudoh Satoshi, Nishigaki Satsuki, Higa Yusuke, Fujikawa Shiori, Fujitani Hiroko, Shintani Ayumi, Hamazaki Takashi, Shintaku Haruo

    (一社)日本アレルギー学会 Allergology International   68 ( 1 )   96 - 100   2019.01( ISSN:1323-8930

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    喘息児における、テトラヒドロビオプテリンの代謝物であるプテリジン類と喘息管理状態の関連性を単一施設前向きコホート研究により検討した。喘息児168例(男児96例、年齢4〜17歳)を対象に、プテリジン類として血清中のネオプテリンとビオプテリンを測定するとともに、呼気一酸化窒素濃度(FeNO)、呼吸機能、鼻好酸球、血中好酸球数、免疫グロブリンE値を測定した。またJapanese Pediatric Asthma Control Program(JPAC)質問票で評価した喘息管理とプテリジンとの関連を推定した。喘息管理状況は、JPACで「完全管理」に分類された症例は58例、Global Initiative for Asthma分類で「管理良好」とされた症例は132例であった。FeNOとネオプテリン値は経過観察期間のJPACスコアとは相関しなかったが、血清ビオプテリン値は経過観察期間のJPAC総スコアおよび運動中の喘鳴頻度とは有意な相関関係があった。血清ビオプテリンは、喘息児の経過観察期間の管理状態に影響しており、ビオプテリン値のモニタリングが喘息管理に有用であることが示唆された。

  • Hypercalcemia Is a Risk Factor for the Progression of Aortic Calcification in Kidney Transplant Recipients Reviewed

    Naganuma Toshihide, Takemoto Yoshiaki, Uchida Junji, Nakatani Tatsuya, Kabata Daijiro, Shintani Ayumi

    KIDNEY & BLOOD PRESSURE RESEARCH   44 ( 4 )   823 - 834   2019( ISSN:1420-4096

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    DOI: 10.1159/000501740

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  • Optimal Biopsy Protocol to Evaluate Histological Effectiveness of Proton Pump Inhibitor Therapy in Patients with Eosinophilic Esophagitis Reviewed

    Fujiwara Yasuhiro, Hashimoto Atsushi, Uemura Risa, Sawada Akinari, Otani Koji, Tanaka Fumio, Yamagami Hirokazu, Tanigawa Tetsuya, Watanabe Toshio, Kabata Daijiro, Kuwae Yuko, Shintani Ayumi, Ohsawa Masahiko

    DIGESTION   100 ( 1 )   64 - 71   2019( ISSN:0012-2823

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    DOI: 10.1159/000494253

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  • ABO不適合腎移植における移植前アフェレシス療法としての選択的血漿交換の有効性(Efficacy of selective plasma exchange as pre-transplant apheresis in ABO-incompatible kidney transplantation)

    Hanaoka Ako, Naganuma Toshihide, Takemoto Yoshiaki, Uchida Junji, Nakatani Tatsuya, Kabata Daijiro, Shintani Ayumi

    Renal Replacement Therapy   5   1 of 7 - 7 of 7   2019

  • ABO-incompatible kidney transplantation as a renal replacement therapy-A single low-volume center experience in Japan Reviewed

    Kosoku Akihiro, Uchida Junji, Nishide Shunji, Kabei Kazuya, Shimada Hisao, Iwai Tomoaki, Kuwabara Nobuyuki, Maeda Keiko, Naganuma Toshihide, Kumada Norihiko, Takemoto Yoshiaki, Ishihara Takuma, Shintani Ayumi, Nakatani Tatsuya

    PLOS ONE   13 ( 12 )   e0208638   2018.12( ISSN:1932-6203

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    DOI: 10.1371/journal.pone.0208638

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  • Establishment of a dual-wavelength spectrophotometric method for analysing and detecting carbapenemase-producing Enterobacteriaceae Reviewed

    Takeuchi Dan, Akeda Yukihiro, Sugawara Yo, Sakamoto Noriko, Yamamoto Norihisa, Shanmugakani Rathina Kumar, Ishihara Takuma, Shintani Ayumi, Tomono Kazunori, Hamada Shigeyuki

    SCIENTIFIC REPORTS   8 ( 1 )   15689   2018.10( ISSN:2045-2322

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    DOI: 10.1038/s41598-018-33883-0

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  • Association of prophylactic synbiotics with reduction in diarrhea and pneumonia in mechanically ventilated critically ill patients: A propensity score analysis Reviewed

    Shimizu Kentaro, Ogura Hiroshi, Kabata Daijiro, Shintani Ayumi, Tasaki Osamu, Ojima Masahiro, Ikeda Mitsunori, Shimazu Takeshi

    JOURNAL OF INFECTION AND CHEMOTHERAPY   24 ( 10 )   795 - 801   2018.10( ISSN:1341-321X

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    DOI: 10.1016/j.jiac.2018.06.006

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  • Effect of monitoring salt concentration of home-prepared dishes and using low-sodium seasonings on sodium intake reduction Reviewed

    Nakadate Misako, Ishihara Junko, Lwasaki Motoki, Kitamura Kaori, Kato Erika, Tanaka Junta, Nakamura Kazutoshi, Ishihara Takuma, Shintani Ayumi, Takachi Ribeka

    EUROPEAN JOURNAL OF CLINICAL NUTRITION   72 ( 10 )   1413 - 1420   2018.10( ISSN:0954-3007

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    DOI: 10.1038/s41430-017-0053-2

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  • Drug-Coated Balloon Angioplasty in Atherosclerosis Patients With Popliteal Artery Involvement Reviewed

    Dohi Tomoharu, Schmidt Andrej, Scheinert Dierk, Bausback Yvonne, Kabata Daijiro, Shintani Ayumi, Sakata Yasushi, Steiner Sabine

    JOURNAL OF ENDOVASCULAR THERAPY   25 ( 5 )   581 - 587   2018.10( ISSN:1526-6028

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    DOI: 10.1177/1526602818786973

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  • 人工呼吸下の重症患者における予防的シンバイオティクスと下痢および肺炎の減少との関連性 傾向スコア解析(Association of prophylactic synbiotics with reduction in diarrhea and pneumonia in mechanically ventilated critically ill patients: A propensity score analysis) Reviewed

    Shimizu Kentaro, Ogura Hiroshi, Kabata Daijiro, Shintani Ayumi, Tasaki Osamu, Ojima Masahiro, Ikeda Mitsunori, Shimazu Takeshi

    エルゼビア・ジャパン(株) Journal of Infection and Chemotherapy   24 ( 9-10 )   795 - 801   2018.10( ISSN:1341-321X

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    人工呼吸器を装着された患者179名(男116名、女63名)を対象とする後ろ向き観察研究を行った。入院後3日までにシンバイオティクスが57名に投与され、122名には投与されなかった。投与群の腸炎発生率は非投与群と比べて有意に低かった。傾向スコアを用いた順序ロジスティック回帰モデルでは、入院後28日までに非投与群と比べて投与群において下痢がなかった日数のオッズ比は4.354であった。また肺炎がなかった日数のオッズ比は2.529であった。菌血症の発生には有意差がみられなかった。以上より、予防的シンバイオティクスは人工呼吸患者の下痢および肺炎を減らすと考えられた。

  • 人工呼吸下の重症患者における予防的シンバイオティクスと下痢および肺炎の減少との関連性 傾向スコア解析(Association of prophylactic synbiotics with reduction in diarrhea and pneumonia in mechanically ventilated critically ill patients: A propensity score analysis) Reviewed

    Shimizu Kentaro, Ogura Hiroshi, Kabata Daijiro, Shintani Ayumi, Tasaki Osamu, Ojima Masahiro, Ikeda Mitsunori, Shimazu Takeshi

    エルゼビア・ジャパン(株) Journal of Infection and Chemotherapy   24 ( 9-10 )   795 - 801   2018.10( ISSN:1341-321X

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    人工呼吸器を装着された患者179名(男116名、女63名)を対象とする後ろ向き観察研究を行った。入院後3日までにシンバイオティクスが57名に投与され、122名には投与されなかった。投与群の腸炎発生率は非投与群と比べて有意に低かった。傾向スコアを用いた順序ロジスティック回帰モデルでは、入院後28日までに非投与群と比べて投与群において下痢がなかった日数のオッズ比は4.354であった。また肺炎がなかった日数のオッズ比は2.529であった。菌血症の発生には有意差がみられなかった。以上より、予防的シンバイオティクスは人工呼吸患者の下痢および肺炎を減らすと考えられた。

  • Acute Brain Dysfunction: Development and Validation of a Daily Prediction Model. Reviewed

    Marra A, Pandharipande PP, Shotwell MS, Chandrasekhar R, Girard TD, Shintani AK, Peelen LM, Moons KGM, Dittus RS, Ely EW, Vasilevskis EE

    Chest   154 ( 2 )   293 - 301   2018.08( ISSN:0012-3692

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    DOI: 10.1016/j.chest.2018.03.013

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  • Evaluating the Effect on Mortality of a No-Tranexamic acid (TXA) Policy for Cardiovascular Surgery Reviewed

    Maeda Takuma, Ishihara Takuma, Miyata Shigeki, Yamashita Kizuku, Sasaki Hiroaki, Kobayashi Junjiro, Ohnishi Yoshihiko, Nishimura Kunihiro, Shintani Ayumi, Iso Hiroyasu

    JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA   32 ( 4 )   1627 - 1634   2018.08( ISSN:1053-0770

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    DOI: 10.1053/j.jvca.2017.10.018

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  • Development and validation of a prediction model for loss of physical function in elderly hemodialysis patients Reviewed

    Fukuma Shingo, Shimizu Sayaka, Shintani Ayumi, Kamitani Tsukasa, Akizawa Tadao, Fukuhara Shunichi

    NEPHROLOGY DIALYSIS TRANSPLANTATION   33 ( 8 )   1452 - 1458   2018.08( ISSN:0931-0509

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    DOI: 10.1093/ndt/gfx260

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  • Current Ventilator and Oxygen Management during General Anesthesia A Multicenter, Cross-sectional Observational Study Reviewed

    Suzuki Satoshi, Mihara Yuko, Hikasa Yukiko, Okahara Shuji, Ishihara Takuma, Shintani Ayumi, Morimatsu Hiroshi

    ANESTHESIOLOGY   129 ( 1 )   67 - 76   2018.07( ISSN:0003-3022

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    DOI: 10.1097/ALN.0000000000002181

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  • Predictors of postoperative bleeding after vitrectomy for vitreous hemorrhage in patients with diabetic retinopathy. Reviewed

    Motoda S, Shiraki N, Ishihara T, Sakaguchi H, Kabata D, Takahara M, Kimura T, Kozawa J, Imagawa A, Nishida K, Shintani A, Iwahashi H, Shimomura I

    Journal of diabetes investigation   9 ( 4 )   940 - 945   2018.07( ISSN:2040-1116

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    DOI: 10.1111/jdi.12791

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  • 糖尿病網膜症患者の硝子体出血に対する硝子体切除後の術後出血の予測因子(Predictors of postoperative bleeding after vitrectomy for vitreous hemorrhage in patients with diabetic retinopathy) Reviewed

    Motoda Saori, Shiraki Nobuhiko, Ishihara Takuma, Sakaguchi Hirokazu, Kabata Daijiro, Takahara Mitsuyoshi, Kimura Takekazu, Kozawa Junji, Imagawa Akihisa, Nishida Kohji, Shintani Ayumi, Iwahashi Hiromi, Shimomura Iichiro

    John Wiley & Sons Australia, Ltd Journal of Diabetes Investigation   9 ( 4 )   940 - 945   2018.07( ISSN:2040-1116

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    糖尿病網膜症の硝子体出血に対する経毛様体扁平部硝子体切除における周術期変数と術後出血との関連性について後向き試験により検討した。2010年4月〜2014年3月に糖尿病網膜症から生じた硝子体出血に対して硝子体切除を受けた患者64例の眼(男性47眼、女性25眼、平均年齢63.2歳)を対象とした。術後出血は12眼に発現した。2項ロジスティック回帰分析を行ったところ、手術時間が、硝子体切除後12週間以内の術後出血との有意な関連が認められた唯一の変数であった。ポアソン回帰分析では、硝子体切除の直前に測定した空腹時血中グルコース、抗血小板薬非投与、降圧剤投与、手術時間が、硝子体切除後52週間以内の出血発現頻度と有意に関連していた。

  • 糖尿病網膜症患者の硝子体出血に対する硝子体切除後の術後出血の予測因子(Predictors of postoperative bleeding after vitrectomy for vitreous hemorrhage in patients with diabetic retinopathy)

    Motoda Saori, Shiraki Nobuhiko, Ishihara Takuma, Sakaguchi Hirokazu, Kabata Daijiro, Takahara Mitsuyoshi, Kimura Takekazu, Kozawa Junji, Imagawa Akihisa, Nishida Kohji, Shintani Ayumi, Iwahashi Hiromi, Shimomura Iichiro

    Journal of Diabetes Investigation   9 ( 4 )   940 - 945   2018.07( ISSN:2040-1116

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    糖尿病網膜症の硝子体出血に対する経毛様体扁平部硝子体切除における周術期変数と術後出血との関連性について後向き試験により検討した。2010年4月~2014年3月に糖尿病網膜症から生じた硝子体出血に対して硝子体切除を受けた患者64例の眼(男性47眼、女性25眼、平均年齢63.2歳)を対象とした。術後出血は12眼に発現した。2項ロジスティック回帰分析を行ったところ、手術時間が、硝子体切除後12週間以内の術後出血との有意な関連が認められた唯一の変数であった。ポアソン回帰分析では、硝子体切除の直前に測定した空腹時血中グルコース、抗血小板薬非投与、降圧剤投与、手術時間が、硝子体切除後52週間以内の出血発現頻度と有意に関連していた。

  • 糖尿病網膜症患者の硝子体出血に対する硝子体切除後の術後出血の予測因子(Predictors of postoperative bleeding after vitrectomy for vitreous hemorrhage in patients with diabetic retinopathy) Reviewed

    Motoda Saori, Shiraki Nobuhiko, Ishihara Takuma, Sakaguchi Hirokazu, Kabata Daijiro, Takahara Mitsuyoshi, Kimura Takekazu, Kozawa Junji, Imagawa Akihisa, Nishida Kohji, Shintani Ayumi, Iwahashi Hiromi, Shimomura Iichiro

    John Wiley & Sons Australia, Ltd Journal of Diabetes Investigation   9 ( 4 )   940 - 945   2018.07( ISSN:2040-1116

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    Publishing type:Research paper (scientific journal)  

    糖尿病網膜症の硝子体出血に対する経毛様体扁平部硝子体切除における周術期変数と術後出血との関連性について後向き試験により検討した。2010年4月〜2014年3月に糖尿病網膜症から生じた硝子体出血に対して硝子体切除を受けた患者64例の眼(男性47眼、女性25眼、平均年齢63.2歳)を対象とした。術後出血は12眼に発現した。2項ロジスティック回帰分析を行ったところ、手術時間が、硝子体切除後12週間以内の術後出血との有意な関連が認められた唯一の変数であった。ポアソン回帰分析では、硝子体切除の直前に測定した空腹時血中グルコース、抗血小板薬非投与、降圧剤投与、手術時間が、硝子体切除後52週間以内の出血発現頻度と有意に関連していた。

  • FACTORS INFLUENCING SATISFACTION IN PATIENTS WITH RHEUMATOID ARTHRITIS TREATED WITH TOCILIZUMAB Reviewed

    Fusama M., Yukioka K., Seki T., Kuroiwa T., Kawamoto K., Manabe Y., Yoshimine Y., Tansuri W., Kawata S., Ishida Y., Yaga M., Higa S., Inoue M., Yukioka C., Higashi K., Kuritani T., Ogata A., Maeda K., Shintani A., Sano H., Yukioka M., Nakahara H.

    ANNALS OF THE RHEUMATIC DISEASES   77   610 - 611   2018.06( ISSN:0003-4967

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    DOI: 10.1136/annrheumdis-2018-eular.5999

  • Sedative Plasma Concentrations and Delirium Risk in Critical Illness. Reviewed

    Stollings JL, Thompson JL, Ferrell BA, Scheinin M, Wilkinson GR, Hughes CG, Shintani AK, Ely EW, Girard TD, Pandharipande PP, Patel MB

    The Annals of pharmacotherapy   52 ( 6 )   513 - 521   2018.06( ISSN:1060-0280

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    DOI: 10.1177/1060028017753480

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  • In response to "benefits and risks of intensive blood-pressure lowering in advanced chronic kidney disease' Reviewed

    Obi Y., Kalantar-Zadeh K., Shintani A., Kovesdy C. P., Hamano T.

    JOURNAL OF INTERNAL MEDICINE   283 ( 6 )   607 - 610   2018.06( ISSN:0954-6820

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/joim.12734

  • CHANGES IN PRACTICE PATTERNS IN JAPAN FROM BEFORE TO AFTER JSDT 2013 GUIDELINES ON HEMODIALYSIS PRESCRIPTIONS Reviewed

    Tomo Tadashi, Larkina Maria, Shintani Ayumi, Ogawa Tomonari, Robinson Bruce, Bieber Brian, Henn Lisa, Pisoni Ronald

    NEPHROLOGY DIALYSIS TRANSPLANTATION   33   2018.05( ISSN:0931-0509

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  • CHANGES IN PRACTICE PATTERNS IN JAPAN FROM BEFORE TO AFTER JSDT 2013 GUIDELINES ON HEMODIALYSIS PRESCRIPTIONS Reviewed

    Tomo Tadashi, Larkina Maria, Shintani Ayumi, Ogawa Tomonari, Robinson Bruce, Bieber Brian, Henn Lisa, Pisoni Ronald

    NEPHROLOGY DIALYSIS TRANSPLANTATION   33   2018.05( ISSN:0931-0509

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  • Public attitudes in Japan toward participation in whole genome sequencing studies Reviewed

    Okita Taketoshi, Ohashi Noriko, Kabata Daijiro, Shintani Ayumi, Kato Kazuto

    HUMAN GENOMICS   12 ( 1 )   21   2018.04( ISSN:1473-9542

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    DOI: 10.1186/s40246-018-0153-7

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  • Recovery of Serum Testosterone Levels and Sexual Function in Patients Treated With Short-term Luteinizing Hormone-releasing Hormone Antagonist as a Neoadjuvant Therapy Before External Radiotherapy for Intermediate-risk Prostate Cancer: Preliminary Prospective Study Reviewed

    Inoue Takahiro, Mizowaki Takashi, Kabata Daijiro, Shintani Ayumi, Terada Naoki, Yamasaki Toshinari, Negoro Hiromitsu, Kobayashi Takashi, Nakamura Kiyonao, Inokuchi Haruo, Ogawa Osamu

    CLINICAL GENITOURINARY CANCER   16 ( 2 )   135 - +   2018.04( ISSN:1558-7673

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    DOI: 10.1016/j.clgc.2017.09.009

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  • Clinical spectrum and prognostic factors of possible UIP pattern on high-resolution CT in patients who underwent surgical lung biopsy Reviewed

    Kondoh Yasuhiro, Taniguchi Hiroyuki, Kataokal Kensuke, Furukawa Taiki, Shintani Ayumi, Fujisawa Tomoyuki, Suda Takafumi, Arita Machiko, Baba Tomohisa, Ichikado Kazuya, Inoue Yoshikazu, Kishi Kazuma, Kishaba Tomoo, Nishiyama Osamu, Ogura Takashi, Tomii Keisuke, Homma Sakae

    PLOS ONE   13 ( 3 )   e0193608   2018.03( ISSN:1932-6203

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    DOI: 10.1371/journal.pone.0193608

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  • Drug retention and discontinuation reasons between seven biologics in patients with rheumatoid arthritis -The ANSWER cohort study- Reviewed

    Ebina Kosuke, Hashimoto Motomu, Yamamoto Wataru, Ohnishi Akira, Kabata Daijiro, Hirano Toru, Hara Ryota, Katayame Masaki, Yoshida Shuzo, Nagai Koji, Son Yonsu, Amuro Hideki, Akashi Kengo, Fujimura Takanori, Hirao Makoto, Yamamoto Keiichi, Shintani Ayumi, Kumanogoh Atsushi, Yoshikawa Hideki

    PLOS ONE   13 ( 3 )   e0194130   2018.03( ISSN:1932-6203

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    DOI: 10.1371/journal.pone.0194130

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  • Efficacy of a concomitant elemental diet to reduce the loss of response to adalimumab in patients with intractable Crohn's disease Reviewed

    Sugita Naoko, Watanabe Kenji, Kamata Noriko, Yukawa Tomomi, Otani Koji, Hosomi Shuhei, Nagami Yasuaki, Tanaka Fumio, Taira Koichi, Yamagami Hirokazu, Tanigawa Tetsuya, Shiba Masatsugu, Watanabe Toshio, Tominaga Kazunari, Kabata Daijiro, Shintani Ayumi, Arakawa Tetsuo, Fujiwara Yasuhiro

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   33 ( 3 )   631 - 637   2018.03( ISSN:0815-9319

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    DOI: 10.1111/jgh.13969

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  • Estimated glomerular filtration rate and the risk-benefit profile of intensive blood pressure control amongst nondiabetic patients: a post hoc analysis of a randomized clinical trial Reviewed

    Obi Y., Kalantar-Zadeh K., Shintani A., Kovesdy C. P., Hamano T.

    JOURNAL OF INTERNAL MEDICINE   283 ( 3 )   314 - 327   2018.03( ISSN:0954-6820

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    DOI: 10.1111/joim.12701

  • EARLY DROPS IN BLOOD CELLS ARE PROGNOSTIC MARKERS IN PATIENTS WITH MAJOR BURNS Reviewed

    Osuka Akinori, Ishihara Takuma, Shimizu Kentaro, Shintani Ayumi, Ogura Hiroshi, Ueyama Masashi

    CRITICAL CARE MEDICINE   46 ( 1 )   766 - 766   2018.01( ISSN:0090-3493

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    DOI: 10.1097/01.ccm.0000529565.64391.72

  • 新臨床研究法を視野に入れて、ビックデータを解析する! Reviewed

    新谷 歩

    日本蘇生学会 蘇生: 日本蘇生学会雑誌   37 ( 3 )   152 - 152   2018( ISSN:0288-4348

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    <p>PDFファイルをご覧ください。</p>

    DOI: 10.11414/jjreanimatology.37.3_152

    CiNii Article

  • 臨床研究におけるキャリアパス

    新谷 歩

    公益社団法人 日本薬学会 ファルマシア   54 ( 10 )   935 - 937   2018( ISSN:0014-8601

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    平成30年4月より施行された臨床研究法により我が国の臨床研究は重要な局面を迎えている。質の高い研究を遂行するためには、豊富な知識と経験を持った人材の育成が喫緊の課題である。臨床研究コーディネーターなど、医薬品開発についての基礎知識や薬剤の基本的知識を持っている薬剤師の参加が大いに求められている。ここに、我が国における臨床研究の背景と求められるキャリアパスについて述べる。

    DOI: 10.14894/faruawpsj.54.10_935

    CiNii Article

  • 臨床研究におけるキャリアパス

    新谷 歩

    ファルマシア   54 ( 10 )   935 - 937   2018( ISSN:00148601

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    平成30年4月より施行された臨床研究法により我が国の臨床研究は重要な局面を迎えている。質の高い研究を遂行するためには、豊富な知識と経験を持った人材の育成が喫緊の課題である。臨床研究コーディネーターなど、医薬品開発についての基礎知識や薬剤の基本的知識を持っている薬剤師の参加が大いに求められている。ここに、我が国における臨床研究の背景と求められるキャリアパスについて述べる。

    DOI: 10.14894/faruawpsj.54.10_935

    CiNii Article

  • Validation of an algorithm that determines stroke diagnostic code accuracy in a Japanese hospital-based cancer registry using electronic medical records Reviewed

    Gon Yasufumi, Kabata Daijiro, Yamamoto Keichi, Shintani Ayumi, Todo Kenichi, Mochizuki Hideki, Sakaguchi Manabu

    BMC MEDICAL INFORMATICS AND DECISION MAKING   17 ( 1 )   157   2017.12( ISSN:1472-6947

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    DOI: 10.1186/s12911-017-0554-x

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  • Epidemiological and outcome data in Japanese patients with deep vein thrombosis with and without malignancy. Reviewed

    Yokoi K, Hara M, Ueda Y, Yamamoto K, Ota K, Kabata D, Kitamura T, Sakata Y, Shintani A

    Heart and vessels   32 ( 12 )   1469 - 1477   2017.12( ISSN:0910-8327

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    DOI: 10.1007/s00380-017-1025-0

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  • 悪性腫瘍を伴う/伴わない日本人深部静脈血栓症患者における疫学的および転帰データ(Epidemiological and outcome data in Japanese patients with deep vein thrombosis with and without malignancy) Reviewed

    Yokoi Kensuke, Hara Masahiko, Ueda Yasunori, Yamamoto Keiichi, Ota Keiko, Kabata Daijiro, Kitamura Tetsuhisa, Sakata Yasushi, Shintani Ayumi

    シュプリンガー・ジャパン(株) Heart and Vessels   32 ( 12 )   1469 - 1477   2017.12( ISSN:0910-8327

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    骨盤または下肢の新規急性深部静脈血栓(DVT)患者211例を対象に、悪性腫瘍患者120例(男性35.0%、年齢58〜75歳)と非悪性腫瘍患者91例(男性31.9%、年齢49〜79歳)の死亡率について検討した。患者の82.9%は直接経口抗凝固薬を含む経口抗凝固薬で治療された。臨床的特徴と治療法は一部の例外を除いて両群間でほとんど同じであった。全集団、悪性腫瘍患者、非悪性腫瘍患者における3年生存率はそれぞれ80.6、67.6、97.6%であった(ログランクp<0.001)。多変量コックス回帰分析では、悪性腫瘍が調整ハザード比9.1(95%信頼区間2.1〜39.0,p=0.003)にて3年全死因死亡率の高リスクと独立して関連することが示された。Bootstrap validationは、多変量モデルにおいて有意な過剰適合なく、0.766の許容可能な指数補正勾配を証明した。日本人DVT患者における疫学的データを解析したところ、悪性腫瘍は3年全死因死亡率と独立して関連することが示唆された。

  • Mitral Valve Structure in Addition to Myocardial Viability Determines the Outcome of Functional Mitral Regurgitation After Coronary Artery Bypass Grafting. Reviewed

    Yoshida S, Fukushima S, Miyagawa S, Nakamura T, Yoshikawa Y, Hata H, Saito S, Yoshioka D, Domae K, Kashiyama N, Yamamoto K, Shintani A, Nakatani S, Toda K, Sawa Y

    Circulation journal : official journal of the Japanese Circulation Society   81 ( 11 )   1620 - 1627   2017.10( ISSN:1346-9843

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    DOI: 10.1253/circj.CJ-16-1280

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  • 僧帽弁構造と心筋バイアビリティは冠動脈バイパス術後の機能的僧帽弁逆流の転帰を決定する(Mitral Valve Structure in Addition to Myocardial Viability Determines the Outcome of Functional Mitral Regurgitation After Coronary Artery Bypass Grafting) Reviewed

    Yoshida Shohei, Fukushima Satsuki, Miyagawa Shigeru, Nakamura Teruya, Yoshikawa Yasushi, Hata Hiroki, Saito Shunsuke, Yoshioka Daisuke, Domae Keitaro, Kashiyama Noriyuki, Yamamoto Kouji, Shintani Ayumi, Nakatani Satoshi, Toda Koichi, Sawa Yoshiki

    (一社)日本循環器学会 Circulation Journal   81 ( 11 )   1620 - 1627   2017.10( ISSN:1346-9843

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    冠動脈バイパス術(CABG)後の機能的僧帽弁逆流(MR)の転帰と僧帽弁構造との関連を調べた。CABGを施行する軽度〜中等度の機能性MRを有する患者66例(男性73%、年齢64〜75歳)を対象に、心エコー検査を用いて術後1年以上にわたりフォローアップした。MRのグレードは術後に34例(52%)で低下した。これらの患者では、術後にMRが残存した患者32例(48%)と比較して、長期心不全発症率が有意に低かった。CABG術後MRの予測因子を多変量解析で検討したところ、既知の予測因子(駆出率、左室拡張末期径、tenting height)に加えて推定coaptation長およびジェット方向を投入すると、予測能が向上した。残存MRはCABG後長期のうっ血性心不全発症と関連した。大きな僧帽弁尖や後尖の支配的tetheringなどの特異的な僧帽弁構造はCABG後の機能的MRの可逆性に対する予測因子であった。

  • 僧帽弁構造と心筋バイアビリティは冠動脈バイパス術後の機能的僧帽弁逆流の転帰を決定する(Mitral Valve Structure in Addition to Myocardial Viability Determines the Outcome of Functional Mitral Regurgitation After Coronary Artery Bypass Grafting) Reviewed

    Yoshida Shohei, Fukushima Satsuki, Miyagawa Shigeru, Nakamura Teruya, Yoshikawa Yasushi, Hata Hiroki, Saito Shunsuke, Yoshioka Daisuke, Domae Keitaro, Kashiyama Noriyuki, Yamamoto Kouji, Shintani Ayumi, Nakatani Satoshi, Toda Koichi, Sawa Yoshiki

    (一社)日本循環器学会 Circulation Journal   81 ( 11 )   1620 - 1627   2017.10( ISSN:1346-9843

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    冠動脈バイパス術(CABG)後の機能的僧帽弁逆流(MR)の転帰と僧帽弁構造との関連を調べた。CABGを施行する軽度〜中等度の機能性MRを有する患者66例(男性73%、年齢64〜75歳)を対象に、心エコー検査を用いて術後1年以上にわたりフォローアップした。MRのグレードは術後に34例(52%)で低下した。これらの患者では、術後にMRが残存した患者32例(48%)と比較して、長期心不全発症率が有意に低かった。CABG術後MRの予測因子を多変量解析で検討したところ、既知の予測因子(駆出率、左室拡張末期径、tenting height)に加えて推定coaptation長およびジェット方向を投入すると、予測能が向上した。残存MRはCABG後長期のうっ血性心不全発症と関連した。大きな僧帽弁尖や後尖の支配的tetheringなどの特異的な僧帽弁構造はCABG後の機能的MRの可逆性に対する予測因子であった。

  • Relationship between atherosclerosis and occlusal support of natural teeth with mediating effect of atheroprotective nutrients: From the SONIC study Reviewed

    Tada Sayaka, Ikebe Kazunori, Kamide Kei, Gondo Yasuyuki, Inomata Chisato, Takeshita Hajime, Matsuda Ken-ich, Kitamura Masahiro, Murakami Shinya, Kabayama Mai, Oguro Ryousuke, Nakama Chikako, Kawai Tatsuo, Yamamoto Koichi, Sugimoto Ken, Shintani Ayumi, Ishihara Takuma, Arai Yasumichi, Masui Yukie, Takahashi Ryutaro, Rakugi Hiromi, Maeda Yoshinobu

    PLOS ONE   12 ( 8 )   e0182563   2017.08( ISSN:1932-6203

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    DOI: 10.1371/journal.pone.0182563

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  • Improving Outcomes of Witnessed Out-of-Hospital Cardiac Arrest After Implementation of International Liaison Committee on Resuscitation 2010 Consensus: A Nationwide Prospective Observational Population-Based Study Reviewed

    Kaneko Hidehiro, Hara Masahiko, Mizutani Kazuki, Yoshiyama Minoru, Yokoi Kensuke, Kabata Daijiro, Shintani Ayumi, Kitamura Tetsuhisa

    JOURNAL OF THE AMERICAN HEART ASSOCIATION   6 ( 8 )   2017.08( ISSN:2047-9980

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    DOI: 10.1161/JAHA.116.004959

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  • Plasma homocysteine and cerebral small vessel disease as possible mediators between kidney and cognitive functions in patients with diabetes mellitus Reviewed

    Sonoda Mika, Shoji Tetsuo, Kuwamura Yukinobu, Okute Yujiro, Naganuma Toshihide, Shima Hideaki, Motoyama Koka, Morioka Tomoaki, Mori Katsuhito, Fukumoto Shinya, Shioi Atsushi, Shimono Taro, Fujii Hisako, Kabata Daijiro, Shintani Ayumi, Emoto Masanori, Inaba Masaaki

    SCIENTIFIC REPORTS   7 ( 1 )   4382   2017.06( ISSN:2045-2322

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    DOI: 10.1038/s41598-017-04515-w

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  • A pragmatic method for transforming clinical research data from the research electronic data capture "REDCap" to Clinical Data Interchange Standards Consortium (CDISC) Study Data Tabulation Model (SDTM): Development and evaluation of REDCap2SDTM Reviewed

    Yamamoto Keiichi, Ota Keiko, Akiya Ippei, Shintani Ayumi

    JOURNAL OF BIOMEDICAL INFORMATICS   70   65 - 76   2017.06( ISSN:1532-0464

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    DOI: 10.1016/j.jbi.2017.05.003

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  • Ideal Guiding Catheter Position During Bilaterally Engaged Percutaneous Coronary Intervention. Reviewed

    Yokoi K, Hara M, Ueda Y, Sumitsuji S, Awata M, Salah YK, Kabata D, Shintani A, Sakata Y

    The American journal of cardiology   119 ( 10 )   1518 - 1524   2017.05( ISSN:0002-9149

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    DOI: 10.1016/j.amjcard.2017.02.026

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  • Efficacy and safety of super selective bronchial artery coil embolisation for haemoptysis: a single-centre retrospective observational study. Reviewed

    Ishikawa H, Hara M, Ryuge M, Takafuji J, Youmoto M, Akira M, Nagasaka Y, Kabata D, Yamamoto K, Shintani A

    BMJ open   7 ( 2 )   e014805   2017.02

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    DOI: 10.1136/bmjopen-2016-014805

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  • Evaluation of a Prediction Model for the Development of Atrial Fibrillation in a Repository of Electronic Medical Records. Reviewed

    Kolek MJ, Graves AJ, Xu M, Bian A, Teixeira PL, Shoemaker MB, Parvez B, Xu H, Heckbert SR, Ellinor PT, Benjamin EJ, Alonso A, Denny JC, Moons KG, Shintani AK, Harrell FE Jr, Roden DM, Darbar D

    JAMA cardiology   1 ( 9 )   1007 - 1013   2016.12( ISSN:2380-6583

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    DOI: 10.1001/jamacardio.2016.3366

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  • Baseline disease is a more important predictor of intestinal necrosis than CT findings in patients with acute mesenteric ischemia. Reviewed

    Ichiba T, Hara M, Yunoki K, Urashima M, Harano M, Naitou H, Yamamoto K, Shintani A

    The American journal of emergency medicine   34 ( 12 )   2261 - 2265   2016.12( ISSN:0735-6757

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    DOI: 10.1016/j.ajem.2016.08.016

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  • Net cholesterol efflux capacity of HDL enriched serum and coronary atherosclerosis in rheumatoid arthritis. Reviewed

    Ormseth MJ, Yancey PG, Yamamoto S, Oeser AM, Gebretsadik T, Shintani A, Linton MF, Fazio S, Davies SS, Roberts LJ 2nd, Vickers KC, Raggi P, Kon V, Stein CM

    IJC metabolic & endocrine   13   6 - 11   2016.12

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    DOI: 10.1016/j.ijcme.2016.08.002

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  • Comprehensive Geriatric Assessment is a useful predictive tool for postoperative delirium after gastrointestinal surgery in old-old adults. Reviewed

    Maekawa Y, Sugimoto K, Yamasaki M, Takeya Y, Yamamoto K, Ohishi M, Ogihara T, Shintani A, Doki Y, Mori M, Rakugi H

    Geriatrics & gerontology international   16 ( 9 )   1036 - 42   2016.09( ISSN:1444-1586

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    DOI: 10.1111/ggi.12587

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  • 高齢者総合的機能評価は後期高齢者の消化管手術後のせん妄に関する有用な予測ツールである(Comprehensive Geriatric Assessment is a useful predictive tool for postoperative delirium after gastrointestinal surgery in old-old adults) Reviewed

    Maekawa Yoshihiro, Sugimoto Ken, Yamasaki Makoto, Takeya Yasushi, Yamamoto Koichi, Ohishi Mitsuru, Ogihara Toshio, Shintani Ayumi, Doki Yuichiro, Mori Masaki, Rakugi Hiromi

    John Wiley & Sons Australia, Ltd Geriatrics & Gerontology International   16 ( 9 )   1036 - 1042   2016.09( ISSN:1444-1586

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    後期高齢患者の手術前における高齢者総合的機能評価による、術後せん妄(POD)の予測について検討した。消化器癌に対する根治的手術を受けた75歳以上の患者517例(男性351名、女性166名、平均年齢79.3歳)を対象とした。術前に高齢者総合的機能評価の各項目およびperformance statusの評価を実施し、PODを含む術後合併症の記録を後向きに作成した。年齢、性別、病型、既往歴、生活習慣関連の併存症、POD、術後合併症、手術方法、手術時間、出血量、輸血量、麻酔方法、BMI、血液検査、のデータを得た。対象の24.0%においてPODが発現した。Barthel Index、簡易知能検査、手段的日常生活動作、老年期うつ病評価尺度の結果はPODの発現率と関連した。術後合併症およびperformance statusに関する従来のリスク因子で調整した後に、POD発現に関連する独立因子として、Barthel Index、簡易知能検査、手段的日常生活動作の結果が特定された。

  • 高齢者総合的機能評価は後期高齢者の消化管手術後のせん妄に関する有用な予測ツールである(Comprehensive Geriatric Assessment is a useful predictive tool for postoperative delirium after gastrointestinal surgery in old-old adults)

    Maekawa Yoshihiro, Sugimoto Ken, Yamasaki Makoto, Takeya Yasushi, Yamamoto Koichi, Ohishi Mitsuru, Ogihara Toshio, Shintani Ayumi, Doki Yuichiro, Mori Masaki, Rakugi Hiromi

    Geriatrics & Gerontology International   16 ( 9 )   1036 - 1042   2016.09( ISSN:1444-1586

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    後期高齢患者の手術前における高齢者総合的機能評価による、術後せん妄(POD)の予測について検討した。消化器癌に対する根治的手術を受けた75歳以上の患者517例(男性351名、女性166名、平均年齢79.3歳)を対象とした。術前に高齢者総合的機能評価の各項目およびperformance statusの評価を実施し、PODを含む術後合併症の記録を後向きに作成した。年齢、性別、病型、既往歴、生活習慣関連の併存症、POD、術後合併症、手術方法、手術時間、出血量、輸血量、麻酔方法、BMI、血液検査、のデータを得た。対象の24.0%においてPODが発現した。Barthel Index、簡易知能検査、手段的日常生活動作、老年期うつ病評価尺度の結果はPODの発現率と関連した。術後合併症およびperformance statusに関する従来のリスク因子で調整した後に、POD発現に関連する独立因子として、Barthel Index、簡易知能検査、手段的日常生活動作の結果が特定された。

  • 高齢者総合的機能評価は後期高齢者の消化管手術後のせん妄に関する有用な予測ツールである(Comprehensive Geriatric Assessment is a useful predictive tool for postoperative delirium after gastrointestinal surgery in old-old adults) Reviewed

    Maekawa Yoshihiro, Sugimoto Ken, Yamasaki Makoto, Takeya Yasushi, Yamamoto Koichi, Ohishi Mitsuru, Ogihara Toshio, Shintani Ayumi, Doki Yuichiro, Mori Masaki, Rakugi Hiromi

    John Wiley & Sons Australia, Ltd Geriatrics & Gerontology International   16 ( 9 )   1036 - 1042   2016.09( ISSN:1444-1586

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    後期高齢患者の手術前における高齢者総合的機能評価による、術後せん妄(POD)の予測について検討した。消化器癌に対する根治的手術を受けた75歳以上の患者517例(男性351名、女性166名、平均年齢79.3歳)を対象とした。術前に高齢者総合的機能評価の各項目およびperformance statusの評価を実施し、PODを含む術後合併症の記録を後向きに作成した。年齢、性別、病型、既往歴、生活習慣関連の併存症、POD、術後合併症、手術方法、手術時間、出血量、輸血量、麻酔方法、BMI、血液検査、のデータを得た。対象の24.0%においてPODが発現した。Barthel Index、簡易知能検査、手段的日常生活動作、老年期うつ病評価尺度の結果はPODの発現率と関連した。術後合併症およびperformance statusに関する従来のリスク因子で調整した後に、POD発現に関連する独立因子として、Barthel Index、簡易知能検査、手段的日常生活動作の結果が特定された。

  • Telomere Length and Coronary Atherosclerosis in Rheumatoid Arthritis. Reviewed

    Ormseth MJ, Solus JF, Oeser AM, Bian A, Gebretsadik T, Shintani A, Raggi P, Stein CM

    The Journal of rheumatology   43 ( 8 )   1469 - 74   2016.08( ISSN:0315-162X

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    DOI: 10.3899/jrheum.151115

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  • The diabetes nutrition education study randomized controlled trial: A comparative effectiveness study of approaches to nutrition in diabetes self-management education. Reviewed

    Bowen ME, Cavanaugh KL, Wolff K, Davis D, Gregory RP, Shintani A, Eden S, Wallston K, Elasy T, Rothman RL

    Patient education and counseling   99 ( 8 )   1368 - 76   2016.08( ISSN:0738-3991

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.pec.2016.03.017

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  • Quantitative Evaluation of the Natural Progression of Keratoconus Using Three-Dimensional Optical Coherence Tomography. Reviewed

    Fujimoto H, Maeda N, Shintani A, Nakagawa T, Fuchihata M, Higashiura R, Nishida K

    Investigative ophthalmology & visual science   57 ( 9 )   OCT169 - 75   2016.07( ISSN:0146-0404

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1167/iovs.15-18650

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  • Measurement and Correlation of Indices of Insulin Resistance in Patients on Peritoneal Dialysis. Reviewed

    King-Morris KR, Deger SM, Hung AM, Egbert PA, Ellis CD, Graves A, Shintani A, Ikizler TA

    Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis   36 ( 4 )   433 - 41   2016.07( ISSN:0896-8608

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    DOI: 10.3747/pdi.2013.00296

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  • A quick and easy delirium assessment for nonphysician research personnel. Reviewed

    Han JH, Wilson A, Graves AJ, Shintani A, Schnelle JF, Ely EW

    The American journal of emergency medicine   34 ( 6 )   1031 - 6   2016.06( ISSN:0735-6757

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.ajem.2016.02.069

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  • Metagenomic Analysis Reveals Dynamic Changes of Whole Gut Microbiota in the Acute Phase of Intensive Care Unit Patients. Reviewed

    Ojima M, Motooka D, Shimizu K, Gotoh K, Shintani A, Yoshiya K, Nakamura S, Ogura H, Iida T, Shimazu T

    Digestive diseases and sciences   61 ( 6 )   1628 - 34   2016.06( ISSN:0163-2116

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s10620-015-4011-3

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  • Effect of Pharmacist Counseling Intervention on Health Care Utilization Following Hospital Discharge: A Randomized Control Trial. Reviewed

    Bell SP, Schnipper JL, Goggins K, Bian A, Shintani A, Roumie CL, Dalal AK, Jacobson TA, Rask KJ, Vaccarino V, Gandhi TK, Labonville SA, Johnson D, Neal EB, Kripalani S, Pharmacist Intervention for Low Literacy in Cardiovascular Disease (PILL-CVD) Study Group.

    Journal of general internal medicine   31 ( 5 )   470 - 7   2016.05( ISSN:0884-8734

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s11606-016-3596-3

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  • Validity of a Modified Sequential Organ Failure Assessment Score Using the Richmond Agitation-Sedation Scale. Reviewed

    Vasilevskis EE, Pandharipande PP, Graves AJ, Shintani A, Tsuruta R, Ely EW, Girard TD

    Critical care medicine   44 ( 1 )   138 - 46   2016.01( ISSN:0090-3493

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1097/CCM.0000000000001375

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  • Comparative Effectiveness of Emergency Resuscitative Thoracotomy versus Closed Chest Compressions among Patients with Critical Blunt Trauma: A Nationwide Cohort Study in Japan. Reviewed

    Suzuki K, Inoue S, Morita S, Watanabe N, Shintani A, Inokuchi S, Ogura S

    PloS one   11 ( 1 )   e0145963   2016

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1371/journal.pone.0145963

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  • The Correlation of Skeletal and Cardiac Muscle Dysfunction in Duchenne Muscular Dystrophy. Reviewed

    Posner AD, Soslow JH, Burnette WB, Bian A, Shintani A, Sawyer DB, Markham LW

    Journal of neuromuscular diseases   3 ( 1 )   91 - 99   2016( ISSN:2214-3599

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.3233/JND-150132

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  • Association of cardiovascular and biochemical risk factors with tibial artery calcification. Reviewed

    Deas DS Jr, Marshall AP, Bian A, Shintani A, Guzman RJ

    Vascular medicine (London, England)   20 ( 4 )   326 - 31   2015.08( ISSN:1358-863X

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1177/1358863X15581448

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  • A longitudinal retrospective study of the analysis of the risk factors of implant failure by the application of generalized estimating equations. Reviewed

    Noda K, Arakawa H, Kimura-Ono A, Yamazaki S, Hara ES, Sonoyama W, Maekawa K, Okura K, Shintani A, Matsuka Y, Kuboki T

    Journal of prosthodontic research   59 ( 3 )   178 - 84   2015.07( ISSN:1883-1958

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    DOI: 10.1016/j.jpor.2015.04.003

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  • 一般化推定方程式の応用によるインプラント失敗の危険因子分析に関する長期後向き研究(A longitudinal retrospective study of the analysis of the risk factors of implant failure by the application of generalized estimating equations) Reviewed

    Noda Kinji, Arakawa Hikaru, Kimura-Ono Aya, Yamazaki Seiya, Hara Emilio Satoshi, Sonoyama Wataru, Maekawa Kenji, Okura Kazuo, Shintani Ayumi, Matsuka Yoshizo, Kuboki Takuo

    (公社)日本補綴歯科学会 Journal of Prosthodontic Research   59 ( 3 )   178 - 184   2015.07( ISSN:1883-1958

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    歯科用インプラント失敗に関する全身的および局所的因子の影響を一般化推定方程式(GEE)により後向きに検討した。1990年2月〜2007年3月に受診した393例のうち、試験対象患者基準を満たした296例の721本のインプラント(1人平均2.44本)を対象に、早期および後期インプラント失敗の予測因子の可能性がある、年齢、性別、喫煙、インプラント部位、骨増生の有無、残存歯数、対合歯の状態、固定装置の長さ、固定装置の直径、上部構造の種類(固定式または可撤式)についてGEEにより検討した。早期インプラント失敗は患者7例における11本(1.5%)で、GEE分析では喫煙のみが早期インプラント失敗の危険因子であった。289例の710インプラントのうち10年累積残存率は94%で、後期インプラント失敗の危険因子は上顎インプラント、臼歯部インプラント、残存指数(20本以上)、対合歯が可撤式局部義歯またはなし、および可撤式上部構造であった。GEE分析の結果、早期インプラント失敗の危険因子は喫煙で、後期インプラント失敗の危険因子には種々のものがあることが示された。

  • The Diagnostic Performance of the Richmond Agitation Sedation Scale for Detecting Delirium in Older Emergency Department Patients. Reviewed

    Han JH, Vasilevskis EE, Schnelle JF, Shintani A, Dittus RS, Wilson A, Ely EW

    Academic emergency medicine : official journal of the Society for Academic Emergency Medicine   22 ( 7 )   878 - 82   2015.07( ISSN:1069-6563

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/acem.12706

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  • 一般化推定方程式の応用によるインプラント失敗の危険因子分析に関する長期後向き研究(A longitudinal retrospective study of the analysis of the risk factors of implant failure by the application of generalized estimating equations) Reviewed

    Noda Kinji, Arakawa Hikaru, Kimura-Ono Aya, Yamazaki Seiya, Hara Emilio Satoshi, Sonoyama Wataru, Maekawa Kenji, Okura Kazuo, Shintani Ayumi, Matsuka Yoshizo, Kuboki Takuo

    (公社)日本補綴歯科学会 Journal of Prosthodontic Research   59 ( 3 )   178 - 184   2015.07( ISSN:1883-1958

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    Publishing type:Research paper (scientific journal)  

    歯科用インプラント失敗に関する全身的および局所的因子の影響を一般化推定方程式(GEE)により後向きに検討した。1990年2月〜2007年3月に受診した393例のうち、試験対象患者基準を満たした296例の721本のインプラント(1人平均2.44本)を対象に、早期および後期インプラント失敗の予測因子の可能性がある、年齢、性別、喫煙、インプラント部位、骨増生の有無、残存歯数、対合歯の状態、固定装置の長さ、固定装置の直径、上部構造の種類(固定式または可撤式)についてGEEにより検討した。早期インプラント失敗は患者7例における11本(1.5%)で、GEE分析では喫煙のみが早期インプラント失敗の危険因子であった。289例の710インプラントのうち10年累積残存率は94%で、後期インプラント失敗の危険因子は上顎インプラント、臼歯部インプラント、残存指数(20本以上)、対合歯が可撤式局部義歯またはなし、および可撤式上部構造であった。GEE分析の結果、早期インプラント失敗の危険因子は喫煙で、後期インプラント失敗の危険因子には種々のものがあることが示された。

  • Functional brain imaging in survivors of critical illness: A prospective feasibility study and exploration of the association between delirium and brain activation patterns. Reviewed

    Jackson JC, Morandi A, Girard TD, Merkle K, Graves AJ, Thompson JL, Shintani AK, Gunther ML, Cannistraci CJ, Rogers BP, Gore JC, Warrington HJ, Ely EW, Hopkins RO, VISualizing Icu SurvivOrs Neuroradiological Sequelae (VISIONS) Investigation.

    Journal of critical care   30 ( 3 )   653.e1 - 7   2015.06( ISSN:0883-9441

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.jcrc.2015.01.017

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  • Reliability and validity assessment of the Japanese version of the Confusion Assessment Method for the Intensive Care Unit (CAM-ICU). Reviewed

    Koga Y, Tsuruta R, Murata H, Matsuo K, Ito T, Ely EW, Shintani A, Wakamatsu H, Sanui M, Yamase H

    Intensive & critical care nursing   31 ( 3 )   165 - 70   2015.06( ISSN:0964-3397

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.iccn.2014.10.002

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  • The relationship between acculturation and infant feeding styles in a Latino population. Reviewed

    Dancel LD, Perrin E, Yin SH, Sanders L, Delamater A, Perreira KM, Bronaugh AB, Eden S, Shintani A, Rothman RL

    Obesity (Silver Spring, Md.)   23 ( 4 )   840 - 6   2015.04( ISSN:1930-7381

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/oby.20986

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  • Variation in the relationship between gestational diabetes diagnosis and total gestational weight gain by race/ethnicity. Reviewed

    Chakkalakal RJ, Gebretsadik T, Jagasia S, Shintani A, Elasy TA

    Diabetes research and clinical practice   108 ( 1 )   e14 - 7   2015.04( ISSN:0168-8227

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.diabres.2015.01.020

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  • Urinary L-FABP predicts poor outcomes in critically ill patients with early acute kidney injury. Reviewed

    Parr SK, Clark AJ, Bian A, Shintani AK, Wickersham NE, Ware LB, Ikizler TA, Siew ED

    Kidney international   87 ( 3 )   640 - 8   2015.03( ISSN:0085-2538

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/ki.2014.301

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  • Development and validation of a prediction model for diagnosing blood stream infections in febrile, non-neutropenic children with cancer. Reviewed

    Esbenshade AJ, Pentima MC, Zhao Z, Shintani A, Esbenshade JC, Simpson ME, Montgomery KC, Lindell RB, Lee H, Wallace A, Garcia KL, Moons KG, Friedman DL

    Pediatric blood & cancer   62 ( 2 )   262 - 268   2015.02( ISSN:1545-5009

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/pbc.25275

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  • Renal dysfunction is an independent risk factor for bleeding after gastric ESD. Reviewed

    Yoshioka T, Nishida T, Tsujii M, Kato M, Hayashi Y, Komori M, Yoshihara H, Nakamura T, Egawa S, Yoshio T, Yamada T, Yabuta T, Yamamoto K, Kinoshita K, Kawai N, Ogiyama H, Nishihara A, Michida T, Iijima H, Shintani A, Takehara T

    Endoscopy international open   3 ( 1 )   E39 - 45   2015.02( ISSN:2364-3722

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1055/s-0034-1390762

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  • Omega-3 fatty acids inhibit the up-regulation of endothelial chemokines in maintenance hemodialysis patients. Reviewed

    Hung AM, Booker C, Ellis CD, Siew ED, Graves AJ, Shintani A, Abumrad NN, Himmelfarb J, Ikizler TA

    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association   30 ( 2 )   266 - 74   2015.02( ISSN:0931-0509

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/ndt/gfu283

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  • Health communication, self-care, and treatment satisfaction among low-income diabetes patients in a public health setting. Reviewed

    White RO, Eden S, Wallston KA, Kripalani S, Barto S, Shintani A, Rothman RL

    Patient education and counseling   98 ( 2 )   144 - 9   2015.02( ISSN:0738-3991

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.pec.2014.10.019

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  • Effect of omega-three polyunsaturated fatty acids on inflammation, oxidative stress, and recurrence of atrial fibrillation. Reviewed

    Darghosian L, Free M, Li J, Gebretsadik T, Bian A, Shintani A, McBride BF, Solus J, Milne G, Crossley GH, Thompson D, Vidaillet H, Okafor H, Darbar D, Murray KT, Stein CM

    The American journal of cardiology   115 ( 2 )   196 - 201   2015.01( ISSN:0002-9149

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.amjcard.2014.10.022

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  • The impact of lymphopenia on delirium in ICU patients. Reviewed

    Inoue S, Vasilevskis EE, Pandharipande PP, Girard TD, Graves AJ, Thompson J, Shintani A, Ely EW

    PloS one   10 ( 5 )   e0126216   2015

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1371/journal.pone.0126216

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  • Administration of IL-1ra improves adiponectin levels in chronic hemodialysis patients. Reviewed

    Hung AM, Limkunakul C, Placido JS, Siew ED, Ellis CD, Shintani A, Ikizler TA

    Journal of nephrology   27 ( 6 )   681 - 8   2014.12( ISSN:1121-8428

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s40620-014-0070-3

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  • Impaired arousal at initial presentation predicts 6-month mortality: an analysis of 1084 acutely ill older patients. Reviewed

    Han JH, Vasilevskis EE, Shintani A, Graves AJ, Schnelle JF, Dittus RS, Powers JS, Wilson A, Storrow AB, Ely EW

    Journal of hospital medicine   9 ( 12 )   772 - 8   2014.12( ISSN:1553-5592

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/jhm.2276

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  • Elevated serum creatine phosphokinase is associated with mortality and inotropic requirement in critically injured adults. Reviewed

    Sowards KJ, Mukherjee K, Norris PR, Shintani A, Ware LB, Roberts LJ 2nd, May AK

    Injury   45 ( 12 )   2096 - 100   2014.12( ISSN:0020-1383

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.injury.2014.09.009

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  • Association between statin use at admission to inpatient rehabilitation and functional status at discharge among older patients. Reviewed

    Morandi A, Girard TD, Shintani A, Turco R, Guerini F, Torpilliesi T, Gentile S, Trabucchi M, Bellelli G

    Rejuvenation research   17 ( 6 )   490 - 5   2014.12( ISSN:1549-1684

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1089/rej.2014.1604

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  • Reversing vascular dysfunction in rheumatoid arthritis: improved augmentation index but not endothelial function with peroxisome proliferator-activated receptor γ agonist therapy. Reviewed

    Ormseth MJ, Oeser AM, Cunningham A, Bian A, Shintani A, Solus J, Tanner SB, Stein CM

    Arthritis & rheumatology (Hoboken, N.J.)   66 ( 9 )   2331 - 8   2014.09( ISSN:2326-5191

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/art.38686

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  • Interaction between maternal prepregnancy body mass index and gestational weight gain shapes infant growth. Reviewed

    Heerman WJ, Bian A, Shintani A, Barkin SL

    Academic pediatrics   14 ( 5 )   463 - 70   2014.09( ISSN:1876-2859

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    DOI: 10.1016/j.acap.2014.05.005

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  • Statins and delirium during critical illness: a multicenter, prospective cohort study. Reviewed

    Morandi A, Hughes CG, Thompson JL, Pandharipande PP, Shintani AK, Vasilevskis EE, Han JH, Jackson JC, Laskowitz DT, Bernard GR, Ely EW, Girard TD

    Critical care medicine   42 ( 8 )   1899 - 909   2014.08( ISSN:0090-3493

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1097/CCM.0000000000000398

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  • Delirium and coma evaluated in mechanically ventilated patients in the intensive care unit in Japan: a multi-institutional prospective observational study. Reviewed

    Tsuruta R, Oda Y, Shintani A, Nunomiya S, Hashimoto S, Nakagawa T, Oida Y, Miyazaki D, Yabe S, Japanese Epidemiology of Delirium in ICUs (JEDI) Study Investigators.

    Journal of critical care   29 ( 3 )   472.e1 - 5   2014.06( ISSN:0883-9441

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.jcrc.2014.01.021

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  • Insulin resistance is associated with increased concentrations of NT-proBNP in rheumatoid arthritis: IL-6 as a potential mediator. Reviewed

    Bradham WS, Ormseth MJ, Oeser A, Solus JF, Gebretsadik T, Shintani A, Stein CM

    Inflammation   37 ( 3 )   801 - 8   2014.06( ISSN:0360-3997

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s10753-013-9799-4

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  • Podocyte injury enhances filtration of liver-derived angiotensinogen and renal angiotensin II generation. Reviewed

    Matsusaka T, Niimura F, Pastan I, Shintani A, Nishiyama A, Ichikawa I

    Kidney international   85 ( 5 )   1068 - 77   2014.05( ISSN:0085-2538

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/ki.2013.453

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  • Obesity, diabetes and survival in maintenance hemodialysis patients. Reviewed

    Deger SM, Ellis CD, Bian A, Shintani A, Ikizler TA, Hung AM

    Renal failure   36 ( 4 )   546 - 51   2014.05( ISSN:0886-022X

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.3109/0886022X.2013.876351

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  • Health literacy and injury prevention behaviors among caregivers of infants. Reviewed

    Heerman WJ, Perrin EM, Yin HS, Sanders LM, Eden SK, Shintani A, Coyne-Beasley T, Bronaugh AB, Barkin SL, Rothman RL

    American journal of preventive medicine   46 ( 5 )   449 - 56   2014.05( ISSN:0749-3797

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.amepre.2014.01.005

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  • Glycemic load is associated with oxidative stress among prevalent maintenance hemodialysis patients. Reviewed

    Limkunakul C, Sundell MB, Pouliot B, Graves AJ, Shintani A, Ikizler TA

    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association   29 ( 5 )   1047 - 53   2014.05( ISSN:0931-0509

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/ndt/gft489

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  • Depression, post-traumatic stress disorder, and functional disability in survivors of critical illness in the BRAIN-ICU study: a longitudinal cohort study. Reviewed

    Jackson JC, Pandharipande PP, Girard TD, Brummel NE, Thompson JL, Hughes CG, Pun BT, Vasilevskis EE, Morandi A, Shintani AK, Hopkins RO, Bernard GR, Dittus RS, Ely EW, Bringing to light the Risk Factors And Incidence of Neuropsychological dysfunction in ICU survivors (BRAIN-ICU) study investigators.

    The Lancet. Respiratory medicine   2 ( 5 )   369 - 79   2014.05( ISSN:2213-2600

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/S2213-2600(14)70051-7

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  • Primer of statistics in dental research: Part II. Invited Reviewed

    Shintani A

    Journal of prosthodontic research   58 ( 2 )   85 - 91   2014.04( ISSN:1883-1958

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    Publishing type:Research paper (scientific journal)   Kind of work:Single Work  

    DOI: 10.1016/j.jpor.2014.03.003

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  • Racial and ethnic differences associated with feeding- and activity-related behaviors in infants. Reviewed

    Perrin EM, Rothman RL, Sanders LM, Skinner AC, Eden SK, Shintani A, Throop EM, Yin HS

    Pediatrics   133 ( 4 )   e857 - 67   2014.04( ISSN:0031-4005

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1542/peds.2013-1326

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  • Parent health literacy and "obesogenic" feeding and physical activity-related infant care behaviors. Reviewed

    Yin HS, Sanders LM, Rothman RL, Shustak R, Eden SK, Shintani A, Cerra ME, Cruzatte EF, Perrin EM

    The Journal of pediatrics   164 ( 3 )   577 - 83.e1   2014.03( ISSN:0022-3476

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.jpeds.2013.11.014

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  • Provision of antioxidant therapy in hemodialysis (PATH): a randomized clinical trial. Reviewed

    Himmelfarb J, Ikizler TA, Ellis C, Wu P, Shintani A, Dalal S, Kaplan M, Chonchol M, Hakim RM

    Journal of the American Society of Nephrology : JASN   25 ( 3 )   623 - 33   2014.03( ISSN:1046-6673

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1681/ASN.2013050545

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  • Antidepressants and suicide attempts in children. Reviewed

    Cooper WO, Callahan ST, Shintani A, Fuchs DC, Shelton RC, Dudley JA, Graves AJ, Ray WA

    Pediatrics   133 ( 2 )   204 - 10   2014.02( ISSN:0031-4005

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1542/peds.2013-0923

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  • Validation of the Confusion Assessment Method for the Intensive Care Unit in older emergency department patients. Reviewed

    Han JH, Wilson A, Graves AJ, Shintani A, Schnelle JF, Dittus RS, Powers JS, Vernon J, Storrow AB, Ely EW

    Academic emergency medicine : official journal of the Society for Academic Emergency Medicine   21 ( 2 )   180 - 7   2014.02( ISSN:1069-6563

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/acem.12309

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  • Delirium in the ICU and subsequent long-term disability among survivors of mechanical ventilation. Reviewed

    Brummel NE, Jackson JC, Pandharipande PP, Thompson JL, Shintani AK, Dittus RS, Gill TM, Bernard GR, Ely EW, Girard TD

    Critical care medicine   42 ( 2 )   369 - 77   2014.02( ISSN:0090-3493

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1097/CCM.0b013e3182a645bd

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  • Brief report: Risk of adverse fetal outcomes associated with immunosuppressive medications for chronic immune-mediated diseases in pregnancy. Reviewed

    Cooper WO, Cheetham TC, Li DK, Stein CM, Callahan ST, Morgan TM, Shintani AK, Chen N, Griffin MR, Ray WA

    Arthritis & rheumatology (Hoboken, N.J.)   66 ( 2 )   444 - 50   2014.02( ISSN:2326-5191

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/art.38262

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  • Primer of statistics in dental research: part I. Invited Reviewed

    Shintani A

    Journal of prosthodontic research   58 ( 1 )   11 - 6   2014.01( ISSN:1883-1958

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    Publishing type:Research paper (scientific journal)   Kind of work:Single Work  

    DOI: 10.1016/j.jpor.2013.12.006

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  • Preliminary efficacy of group medical nutrition therapy and motivational interviewing among obese African American women with type 2 diabetes: a pilot study. Reviewed

    Miller ST, Oates VJ, Brooks MA, Shintani A, Gebretsadik T, Jenkins DM

    Journal of obesity   2014   345941   2014( ISSN:2090-0708

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1155/2014/345941

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  • Higher serum iron is associated with increased oxidant stress in HIV-infected men. Reviewed

    Crist MB, Melekhin VV, Bian A, Shintani A, Milne GL, Kallianpur AR, Dageforde LA, Haas DW, Hulgan T

    Journal of acquired immune deficiency syndromes (1999)   64 ( 4 )   367 - 73   2013.12( ISSN:1525-4135

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    DOI: 10.1097/QAI.0b013e3182a60f36

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  • Exploring the utility of ultra-brief delirium assessments in a nonintensive care geriatric population: the GEM study. Reviewed

    Powers JS, Doering T, Gordon S, Eden SK, Shintani A, Schnelle J

    The Gerontologist   53 ( 6 )   1051 - 5   2013.12( ISSN:0016-9013

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/geront/gns161

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  • Diagnosing delirium in older emergency department patients: validity and reliability of the delirium triage screen and the brief confusion assessment method. Reviewed

    Han JH, Wilson A, Vasilevskis EE, Shintani A, Schnelle JF, Dittus RS, Graves AJ, Storrow AB, Shuster J, Ely EW

    Annals of emergency medicine   62 ( 5 )   457 - 465   2013.11( ISSN:0196-0644

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.annemergmed.2013.05.003

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  • Inflammation and hypertension in rheumatoid arthritis. Reviewed

    Manavathongchai S, Bian A, Rho YH, Oeser A, Solus JF, Gebretsadik T, Shintani A, Stein CM

    The Journal of rheumatology   40 ( 11 )   1806 - 11   2013.11( ISSN:0315-162X

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.3899/jrheum.130394

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  • Distinct injury markers for the early detection and prognosis of incident acute kidney injury in critically ill adults with preserved kidney function. Reviewed

    Siew ED, Ware LB, Bian A, Shintani A, Eden SK, Wickersham N, Cripps B, Ikizler TA

    Kidney international   84 ( 4 )   786 - 94   2013.10( ISSN:0085-2538

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/ki.2013.174

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  • Association of epicardial adipose tissue with cardiometabolic risk and metabolic syndrome in patients with rheumatoid arthritis. Reviewed

    Ormseth MJ, Lipson A, Alexopoulos N, Hartlage GR, Oeser AM, Bian A, Gebretsadik T, Shintani A, Raggi P, Stein CM

    Arthritis care & research   65 ( 9 )   1410 - 5   2013.09( ISSN:2151-464X

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/acr.22027

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  • Fluoroquinolone susceptibility in Mycobacterium tuberculosis after pre-diagnosis exposure to older- versus newer-generation fluoroquinolones. Reviewed

    van der Heijden YF, Maruri F, Blackman A, Mitchel E, Bian A, Shintani AK, Eden S, Warkentin JV, Sterling TR

    International journal of antimicrobial agents   42 ( 3 )   232 - 7   2013.09( ISSN:0924-8579

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.ijantimicag.2013.04.027

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  • Effect of intravenous haloperidol on the duration of delirium and coma in critically ill patients (Hope-ICU): a randomised, double-blind, placebo-controlled trial. Reviewed

    Page VJ, Ely EW, Gates S, Zhao XB, Alce T, Shintani A, Jackson J, Perkins GD, McAuley DF

    The Lancet. Respiratory medicine   1 ( 7 )   515 - 23   2013.09( ISSN:2213-2600

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/S2213-2600(13)70166-8

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  • Atypical sleep in ventilated patients: empirical electroencephalography findings and the path toward revised ICU sleep scoring criteria. Reviewed

    Watson PL, Pandharipande P, Gehlbach BK, Thompson JL, Shintani AK, Dittus BS, Bernard GR, Malow BA, Ely EW

    Critical care medicine   41 ( 8 )   1958 - 67   2013.08( ISSN:0090-3493

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1097/CCM.0b013e31828a3f75

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  • Adverse drug events during AKI and its recovery. Reviewed

    Cox ZL, McCoy AB, Matheny ME, Bhave G, Peterson NB, Siew ED, Lewis J, Danciu I, Bian A, Shintani A, Ikizler TA, Neal EB, Peterson JF

    Clinical journal of the American Society of Nephrology : CJASN   8 ( 7 )   1070 - 8   2013.07( ISSN:1555-9041

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.2215/CJN.11921112

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  • Pilot study of a physician-delivered education tool to increase patient knowledge about CKD. Reviewed

    Wright Nunes J, Greene JH, Wallston K, Eden S, Shintani A, Elasy T, Rothman RL, Ikizler TA, Cavanaugh KL

    American journal of kidney diseases : the official journal of the National Kidney Foundation   62 ( 1 )   23 - 32   2013.07( ISSN:0272-6386

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    DOI: 10.1053/j.ajkd.2013.01.023

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  • Circulating interleukin-6, soluble CD14, and other inflammation biomarker levels differ between obese and nonobese HIV-infected adults on antiretroviral therapy. Reviewed

    Koethe JR, Dee K, Bian A, Shintani A, Turner M, Bebawy S, Sterling TR, Hulgan T

    AIDS research and human retroviruses   29 ( 7 )   1019 - 25   2013.07( ISSN:0889-2229

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1089/aid.2013.0016

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  • Inappropriate medication prescriptions in elderly adults surviving an intensive care unit hospitalization. Reviewed

    Morandi A, Vasilevskis E, Pandharipande PP, Girard TD, Solberg LM, Neal EB, Koestner T, Torres RE, Thompson JL, Shintani AK, Han JH, Schnelle JF, Fick DM, Ely EW, Kripalani S

    Journal of the American Geriatrics Society   61 ( 7 )   1128 - 34   2013.07( ISSN:0002-8614

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    DOI: 10.1111/jgs.12329

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  • A pilot study of active vitamin D administration and insulin resistance in African American patients undergoing chronic hemodialysis. Reviewed

    Hung AM, Sundell MB, Plotnikova NE, Bian A, Shintani A, Ellis CD, Siew ED, Ikizler TA

    Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation   23 ( 3 )   185 - 93   2013.05( ISSN:1051-2276

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1053/j.jrn.2012.06.005

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  • Effects of pressure and electrical charge on macromolecular transport across bovine lens basement membrane. Reviewed

    Ferrell N, Cameron KO, Groszek JJ, Hofmann CL, Li L, Smith RA, Bian A, Shintani A, Zydney AL, Fissell WH

    Biophysical journal   104 ( 7 )   1476 - 84   2013.04( ISSN:0006-3495

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.bpj.2013.01.062

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  • Long-term effects of daily hemodialysis on vascular access outcomes: a prospective controlled study. Reviewed

    Achinger SG, Ikizler TA, Bian A, Shintani A, Ayus JC

    Hemodialysis international. International Symposium on Home Hemodialysis   17 ( 2 )   208 - 15   2013.04( ISSN:1492-7535

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/j.1542-4758.2012.00756.x

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  • Neuropsychometric correlates of efavirenz pharmacokinetics and pharmacogenetics following a single oral dose. Reviewed

    Johnson DH, Gebretsadik T, Shintani A, Mayo G, Acosta EP, Stein CM, Haas DW

    British journal of clinical pharmacology   75 ( 4 )   997 - 1006   2013.04( ISSN:0306-5251

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/j.1365-2125.2012.04454.x

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  • Association between endothelial dysfunction and acute brain dysfunction during critical illness. Reviewed

    Hughes CG, Morandi A, Girard TD, Riedel B, Thompson JL, Shintani AK, Pun BT, Ely EW, Pandharipande PP

    Anesthesiology   118 ( 3 )   631 - 9   2013.03( ISSN:0003-3022

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1097/ALN.0b013e31827bd193

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  • Association of foot ulcer with tibial artery calcification is independent of peripheral occlusive disease in type 2 diabetes. Reviewed

    Guzman RJ, Bian A, Shintani A, Stein CM

    Diabetes research and clinical practice   99 ( 3 )   281 - 6   2013.03( ISSN:0168-8227

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.diabres.2012.12.022

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  • Delirium in the cardiovascular ICU: exploring modifiable risk factors. Reviewed

    McPherson JA, Wagner CE, Boehm LM, Hall JD, Johnson DC, Miller LR, Burns KM, Thompson JL, Shintani AK, Ely EW, Pandharipande PP

    Critical care medicine   41 ( 2 )   405 - 13   2013.02( ISSN:0090-3493

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1097/CCM.0b013e31826ab49b

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  • An association between adiposity and serum levels of macrophage inflammatory protein-1α and soluble CD14 in HIV-infected adults: results from a cross-sectional study. Reviewed

    Koethe JR, Bian A, Shintani AK, Wester CW, Erdem H, Hulgan T

    Antiviral therapy   18 ( 5 )   729 - 33   2013( ISSN:1359-6535

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.3851/IMP2645

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  • Peroxisome proliferator-activated receptor γ agonist effect on rheumatoid arthritis: a randomized controlled trial. Reviewed

    Ormseth MJ, Oeser AM, Cunningham A, Bian A, Shintani A, Solus J, Tanner S, Stein CM

    Arthritis research & therapy   15 ( 5 )   R110   2013( ISSN:1478-6354

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/ar4290

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  • Dysfunctional high-density lipoprotein in patients on chronic hemodialysis. Reviewed

    Yamamoto S, Yancey PG, Ikizler TA, Jerome WG, Kaseda R, Cox B, Bian A, Shintani A, Fogo AB, Linton MF, Fazio S, Kon V

    Journal of the American College of Cardiology   60 ( 23 )   2372 - 9   2012.12( ISSN:0735-1097

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.jacc.2012.09.013

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  • Associations of markers of inflammation and coagulation with delirium during critical illness. Reviewed

    Girard TD, Ware LB, Bernard GR, Pandharipande PP, Thompson JL, Shintani AK, Jackson JC, Dittus RS, Ely EW

    Intensive care medicine   38 ( 12 )   1965 - 73   2012.12( ISSN:0342-4642

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00134-012-2678-x

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  • Diurnal sedative changes during intensive care: impact on liberation from mechanical ventilation and delirium. Reviewed

    Seymour CW, Pandharipande PP, Koestner T, Hudson LD, Thompson JL, Shintani AK, Ely EW, Girard TD

    Critical care medicine   40 ( 10 )   2788 - 96   2012.10( ISSN:0090-3493

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1097/CCM.0b013e31825b8ade

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  • Epicardial adipose tissue is increased in patients with systemic lupus erythematosus. Reviewed

    Lipson A, Alexopoulos N, Hartlage GR, Arepalli C, Oeser A, Bian A, Gebretsadik T, Shintani A, Stillman AE, Stein CM, Raggi P

    Atherosclerosis   223 ( 2 )   389 - 93   2012.08( ISSN:0021-9150

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.atherosclerosis.2012.06.006

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  • Abnormal immune responses in persons with previous extrapulmonary tuberculosis in an in vitro model that simulates in vivo infection with Mycobacterium tuberculosis. Reviewed

    Fiske CT, de Almeida AS, Shintani AK, Kalams SA, Sterling TR

    Clinical and vaccine immunology : CVI   19 ( 8 )   1142 - 9   2012.08( ISSN:1556-6811

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1128/CVI.00221-12

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  • Effect of a pharmacist intervention on clinically important medication errors after hospital discharge: a randomized trial. Reviewed

    Kripalani S, Roumie CL, Dalal AK, Cawthon C, Businger A, Eden SK, Shintani A, Sponsler KC, Harris LJ, Theobald C, Huang RL, Scheurer D, Hunt S, Jacobson TA, Rask KJ, Vaccarino V, Gandhi TK, Bates DW, Williams MV, Schnipper JL, PILL-CVD (Pharmacist Intervention for Low Literacy in Cardiovascular Disease) Study Group.

    Annals of internal medicine   157 ( 1 )   1 - 10   2012.07( ISSN:0003-4819

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.7326/0003-4819-157-1-201207030-00003

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  • The association between brain volumes, delirium duration, and cognitive outcomes in intensive care unit survivors: the VISIONS cohort magnetic resonance imaging study*. Reviewed

    Gunther ML, Morandi A, Krauskopf E, Pandharipande P, Girard TD, Jackson JC, Thompson J, Shintani AK, Geevarghese S, Miller RR 3rd, Canonico A, Merkle K, Cannistraci CJ, Rogers BP, Gatenby JC, Heckers S, Gore JC, Hopkins RO, Ely EW, VISIONS Investigation, VISualizing Icu SurvivOrs Neuroradiological Sequelae.

    Critical care medicine   40 ( 7 )   2022 - 32   2012.07( ISSN:0090-3493

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1097/CCM.0b013e318250acc0

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  • The relationship between delirium duration, white matter integrity, and cognitive impairment in intensive care unit survivors as determined by diffusion tensor imaging: the VISIONS prospective cohort magnetic resonance imaging study*. Reviewed

    Morandi A, Rogers BP, Gunther ML, Merkle K, Pandharipande P, Girard TD, Jackson JC, Thompson J, Shintani AK, Geevarghese S, Miller RR 3rd, Canonico A, Cannistraci CJ, Gore JC, Ely EW, Hopkins RO, VISIONS Investigation, VISualizing Icu SurvivOrs Neuroradiological Sequelae.

    Critical care medicine   40 ( 7 )   2182 - 9   2012.07( ISSN:0090-3493

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1097/CCM.0b013e318250acdc

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  • Serum leptin level mediates the association of body composition and serum C-reactive protein in HIV-infected persons on antiretroviral therapy. Reviewed

    Koethe JR, Bian A, Shintani AK, Boger MS, Mitchell VJ, Erdem H, Hulgan T

    AIDS research and human retroviruses   28 ( 6 )   552 - 7   2012.06( ISSN:0889-2229

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1089/aid.2011.0232

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  • High proportion of fluoroquinolone-resistant Mycobacterium tuberculosis isolates with novel gyrase polymorphisms and a gyrA region associated with fluoroquinolone susceptibility. Reviewed

    Devasia R, Blackman A, Eden S, Li H, Maruri F, Shintani A, Alexander C, Kaiga A, Stratton CW, Warkentin J, Tang YW, Sterling TR

    Journal of clinical microbiology   50 ( 4 )   1390 - 6   2012.04( ISSN:0095-1137

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1128/JCM.05286-11

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  • Cognitive and physical rehabilitation of intensive care unit survivors: results of the RETURN randomized controlled pilot investigation. Reviewed

    Jackson JC, Ely EW, Morey MC, Anderson VM, Denne LB, Clune J, Siebert CS, Archer KR, Torres R, Janz D, Schiro E, Jones J, Shintani AK, Levine B, Pun BT, Thompson J, Brummel NE, Hoenig H

    Critical care medicine   40 ( 4 )   1088 - 97   2012.04( ISSN:0090-3493

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1097/CCM.0b013e3182373115

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  • The association of the kynurenine pathway of tryptophan metabolism with acute brain dysfunction during critical illness*. Reviewed

    Adams Wilson JR, Morandi A, Girard TD, Thompson JL, Boomershine CS, Shintani AK, Ely EW, Pandharipande PP

    Critical care medicine   40 ( 3 )   835 - 41   2012.03( ISSN:0090-3493

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1097/CCM.0b013e318236f62d

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  • High-sensitivity cardiac troponin-I is elevated in patients with rheumatoid arthritis, independent of cardiovascular risk factors and inflammation. Reviewed

    Bradham WS, Bian A, Oeser A, Gebretsadik T, Shintani A, Solus J, Estis J, Lu QA, Todd J, Raggi P, Stein CM

    PloS one   7 ( 6 )   e38930   2012

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1371/journal.pone.0038930

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  • Sex differences in urinary biomarkers of vascular and endothelial function in HIV-infected persons receiving antiretroviral therapy. Reviewed

    Boger MS, Bian A, Shintani A, Milne GL, Morrow JD, Erdem H, Mitchell V, Haas DW, Hulgan T

    Antiviral therapy   17 ( 3 )   485 - 93   2012( ISSN:1359-6535

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.3851/IMP1990

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  • Associations among perceived and objective disease knowledge and satisfaction with physician communication in patients with chronic kidney disease. Reviewed

    Wright Nunes JA, Wallston KA, Eden SK, Shintani AK, Ikizler TA, Cavanaugh KL

    Kidney international   80 ( 12 )   1344 - 51   2011.12( ISSN:0085-2538

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/ki.2011.240

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  • Free fatty acids are associated with insulin resistance but not coronary artery atherosclerosis in rheumatoid arthritis. Reviewed

    Ormseth MJ, Swift LL, Fazio S, Linton MF, Chung CP, Raggi P, Rho YH, Solus J, Oeser A, Bian A, Gebretsadik T, Shintani A, Stein CM

    Atherosclerosis   219 ( 2 )   869 - 74   2011.12( ISSN:0021-9150

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.atherosclerosis.2011.09.005

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  • Diagnostic performance of quantitative fecal immunochemical test and multivariate prediction model for colorectal neoplasms in asymptomatic individuals. Reviewed

    Omata F, Shintani A, Isozaki M, Masuda K, Fujita Y, Fukui T

    European journal of gastroenterology & hepatology   23 ( 11 )   1036 - 41   2011.11( ISSN:0954-691X

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1097/MEG.0b013e32834a2882

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  • Delirium and sedation recognition using validated instruments: reliability of bedside intensive care unit nursing assessments from 2007 to 2010. Reviewed

    Vasilevskis EE, Morandi A, Boehm L, Pandharipande PP, Girard TD, Jackson JC, Thompson JL, Shintani A, Gordon SM, Pun BT, Ely EW

    Journal of the American Geriatrics Society   59 Suppl 2   S249 - 55   2011.11( ISSN:0002-8614

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/j.1532-5415.2011.03673.x

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  • Cystatin C, renal function, and atherosclerosis in rheumatoid arthritis. Reviewed

    Lertnawapan R, Bian A, Rho YH, Kawai VK, Raggi P, Oeser A, Solus JF, Gebretsadik T, Shintani A, Stein CM

    The Journal of rheumatology   38 ( 11 )   2297 - 300   2011.11( ISSN:0315-162X

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.3899/jrheum.110168

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  • Dapsone-induced methemoglobinemia: a dose-related occurrence? Reviewed

    Esbenshade AJ, Ho RH, Shintani A, Zhao Z, Smith LA, Friedman DL

    Cancer   117 ( 15 )   3485 - 92   2011.08( ISSN:0008-543X

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/cncr.25904

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  • Podocyte injury damages other podocytes. Reviewed

    Matsusaka T, Sandgren E, Shintani A, Kon V, Pastan I, Fogo AB, Ichikawa I

    Journal of the American Society of Nephrology : JASN   22 ( 7 )   1275 - 85   2011.07( ISSN:1046-6673

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1681/ASN.2010090963

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  • Inappropriate medications in elderly ICU survivors: where to intervene? Reviewed

    Morandi A, Vasilevskis EE, Pandharipande PP, Girard TD, Solberg LM, Neal EB, Koestner T, Torres R, Thompson JL, Shintani AK, Han JH, Schnelle J, Fick DM, Ely EW, Kripalani S

    Archives of internal medicine   171 ( 11 )   1032 - 4   2011.06( ISSN:0003-9926

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1001/archinternmed.2011.233

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  • The effect of cognitive impairment on the accuracy of the presenting complaint and discharge instruction comprehension in older emergency department patients. Reviewed

    Han JH, Bryce SN, Ely EW, Kripalani S, Morandi A, Shintani A, Jackson JC, Storrow AB, Dittus RS, Schnelle J

    Annals of emergency medicine   57 ( 6 )   662 - 671.e2   2011.06( ISSN:0196-0644

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.annemergmed.2010.12.002

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  • Delirium in older emergency department patients is an independent predictor of hospital length of stay. Reviewed

    Han JH, Eden S, Shintani A, Morandi A, Schnelle J, Dittus RS, Storrow AB, Ely EW

    Academic emergency medicine : official journal of the Society for Academic Emergency Medicine   18 ( 5 )   451 - 7   2011.05( ISSN:1069-6563

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/j.1553-2712.2011.01065.x

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  • Effects of combination tocopherols and alpha lipoic acid therapy on oxidative stress and inflammatory biomarkers in chronic kidney disease. Reviewed

    Ramos LF, Kane J, McMonagle E, Le P, Wu P, Shintani A, Ikizler TA, Himmelfarb J

    Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation   21 ( 3 )   211 - 8   2011.05( ISSN:1051-2276

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1053/j.jrn.2010.08.003

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  • A comparison of novel and commonly-used indices of insulin sensitivity in African American chronic hemodialysis patients. Reviewed

    Hung AM, Sundell MB, Egbert P, Siew ED, Shintani A, Ellis CD, Bian A, Ikizler TA

    Clinical journal of the American Society of Nephrology : CJASN   6 ( 4 )   767 - 74   2011.04( ISSN:1555-9041

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.2215/CJN.08070910

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  • Macrophage activation and coronary atherosclerosis in systemic lupus erythematosus and rheumatoid arthritis. Reviewed

    Rho YH, Solus J, Raggi P, Oeser A, Gebretsadik T, Shintani A, Stein CM

    Arthritis care & research   63 ( 4 )   535 - 41   2011.04( ISSN:2151-464X

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/acr.20365

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  • IL-1β receptor antagonist reduces inflammation in hemodialysis patients. Reviewed

    Hung AM, Ellis CD, Shintani A, Booker C, Ikizler TA

    Journal of the American Society of Nephrology : JASN   22 ( 3 )   437 - 42   2011.03( ISSN:1046-6673

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1681/ASN.2010070760

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  • The effect of resistance exercise to augment long-term benefits of intradialytic oral nutritional supplementation in chronic hemodialysis patients. Reviewed

    Dong J, Sundell MB, Pupim LB, Wu P, Shintani A, Ikizler TA

    Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation   21 ( 2 )   149 - 59   2011.03( ISSN:1051-2276

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1053/j.jrn.2010.03.004

    PubMed

  • Diagnosing delirium in critically ill children: Validity and reliability of the Pediatric Confusion Assessment Method for the Intensive Care Unit. Reviewed

    Smith HA, Boyd J, Fuchs DC, Melvin K, Berry P, Shintani A, Eden SK, Terrell MK, Boswell T, Wolfram K, Sopfe J, Barr FE, Pandharipande PP, Ely EW

    Critical care medicine   39 ( 1 )   150 - 7   2011.01( ISSN:0090-3493

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    DOI: 10.1097/CCM.0b013e3181feb489

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  • Procalcitonin and C-reactive protein levels at admission as predictors of duration of acute brain dysfunction in critically ill patients. Reviewed

    McGrane S, Girard TD, Thompson JL, Shintani AK, Woodworth A, Ely EW, Pandharipande PP

    Critical care (London, England)   15 ( 2 )   R78   2011( ISSN:1364-8535

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/cc10070

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  • Delirium duration and mortality in lightly sedated, mechanically ventilated intensive care patients. Reviewed

    Shehabi Y, Riker RR, Bokesch PM, Wisemandle W, Shintani A, Ely EW, SEDCOM (Safety and Efficacy of Dexmedetomidine Compared With Midazolam) Study Group.

    Critical care medicine   38 ( 12 )   2311 - 8   2010.12( ISSN:0090-3493

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1097/CCM.0b013e3181f85759

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  • Low health literacy associates with increased mortality in ESRD. Reviewed

    Cavanaugh KL, Wingard RL, Hakim RM, Eden S, Shintani A, Wallston KA, Huizinga MM, Elasy TA, Rothman RL, Ikizler TA

    Journal of the American Society of Nephrology : JASN   21 ( 11 )   1979 - 85   2010.11( ISSN:1046-6673

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    DOI: 10.1681/ASN.2009111163

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  • Interaction between oxidative stress and high-density lipoprotein cholesterol is associated with severity of coronary artery calcification in rheumatoid arthritis. Reviewed

    Rho YH, Chung CP, Oeser A, Solus JF, Gebretsadik T, Shintani A, Raggi P, Milne GL, Stein CM

    Arthritis care & research   62 ( 10 )   1473 - 80   2010.10( ISSN:2151-464X

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/acr.20237

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  • Delirium in the emergency department: an independent predictor of death within 6 months. Reviewed

    Han JH, Shintani A, Eden S, Morandi A, Solberg LM, Schnelle J, Dittus RS, Storrow AB, Ely EW

    Annals of emergency medicine   56 ( 3 )   244 - 252.e1   2010.09( ISSN:0196-0644

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.annemergmed.2010.03.003

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  • Prevalence and risk factors for development of delirium in burn intensive care unit patients. Reviewed

    Agarwal V, O'Neill PJ, Cotton BA, Pun BT, Haney S, Thompson J, Kassebaum N, Shintani A, Guy J, Ely EW, Pandharipande P

    Journal of burn care & research : official publication of the American Burn Association   31 ( 5 )   706 - 15   2010.09( ISSN:1559-047X

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1097/BCR.0b013e3181eebee9

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  • Elevated urinary IL-18 levels at the time of ICU admission predict adverse clinical outcomes. Reviewed

    Siew ED, Ikizler TA, Gebretsadik T, Shintani A, Wickersham N, Bossert F, Peterson JF, Parikh CR, May AK, Ware LB

    Clinical journal of the American Society of Nephrology : CJASN   5 ( 8 )   1497 - 505   2010.08( ISSN:1555-9041

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.2215/CJN.09061209

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  • Long-term cognitive and psychological outcomes in the awakening and breathing controlled trial. Reviewed

    Jackson JC, Girard TD, Gordon SM, Thompson JL, Shintani AK, Thomason JW, Pun BT, Canonico AE, Dunn JG, Bernard GR, Dittus RS, Ely EW

    American journal of respiratory and critical care medicine   182 ( 2 )   183 - 91   2010.07( ISSN:1073-449X

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1164/rccm.200903-0442OC

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  • Delirium as a predictor of long-term cognitive impairment in survivors of critical illness. Reviewed

    Girard TD, Jackson JC, Pandharipande PP, Pun BT, Thompson JL, Shintani AK, Gordon SM, Canonico AE, Dittus RS, Bernard GR, Ely EW

    Critical care medicine   38 ( 7 )   1513 - 20   2010.07( ISSN:0090-3493

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1097/CCM.0b013e3181e47be1

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  • Adipocytokines, insulin resistance, and coronary atherosclerosis in rheumatoid arthritis. Reviewed

    Rho YH, Chung CP, Solus JF, Raggi P, Oeser A, Gebretsadik T, Shintani A, Stein CM

    Arthritis and rheumatism   62 ( 5 )   1259 - 64   2010.05( ISSN:0004-3591

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/art.27376

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  • Angiotensin receptor blocker protection against podocyte-induced sclerosis is podocyte angiotensin II type 1 receptor-independent. Reviewed

    Matsusaka T, Asano T, Niimura F, Kinomura M, Shimizu A, Shintani A, Pastan I, Fogo AB, Ichikawa I

    Hypertension (Dallas, Tex. : 1979)   55 ( 4 )   967 - 73   2010.04( ISSN:0194-911X

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1161/HYPERTENSIONAHA.109.141994

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  • Immortal time bias in critical care. Reviewed

    Shintani AK, Girard TD, Ely EW

    Critical care medicine   38 ( 4 )   1229   2010.04( ISSN:0090-3493

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1097/CCM.0b013e3181ce473d

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  • Feasibility, efficacy, and safety of antipsychotics for intensive care unit delirium: the MIND randomized, placebo-controlled trial. Reviewed

    Girard TD, Pandharipande PP, Carson SS, Schmidt GA, Wright PE, Canonico AE, Pun BT, Thompson JL, Shintani AK, Meltzer HY, Bernard GR, Dittus RS, Ely EW, MIND Trial Investigators.

    Critical care medicine   38 ( 2 )   428 - 37   2010.02( ISSN:0090-3493

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1097/ccm.0b013e3181c58715

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  • Delirium and mortality risk prediction: a story in evolution. Reviewed

    Vasilevskis EE, Han JH, Shintani A, Girard TD, Ely EW

    Critical care (London, England)   14 ( 5 )   449; author reply 449   2010( ISSN:1364-8535

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/cc9282

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  • Effect of dexmedetomidine versus lorazepam on outcome in patients with sepsis: an a priori-designed analysis of the MENDS randomized controlled trial. Reviewed

    Pandharipande PP, Sanders RD, Girard TD, McGrane S, Thompson JL, Shintani AK, Herr DL, Maze M, Ely EW, MENDS investigators.

    Critical care (London, England)   14 ( 2 )   R38   2010( ISSN:1364-8535

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/cc8916

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  • Highly sensitive C-reactive protein, body mass index, and serum lipids in HIV-infected persons receiving antiretroviral therapy: a longitudinal study. Reviewed

    Boger MS, Shintani A, Redhage LA, Mitchell V, Haas DW, Morrow JD, Hulgan T

    Journal of acquired immune deficiency syndromes (1999)   52 ( 4 )   480 - 7   2009.12( ISSN:1525-4135

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1097/qai.0b013e3181b939e5

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  • Addressing literacy and numeracy to improve diabetes care: two randomized controlled trials. Reviewed

    Cavanaugh K, Wallston KA, Gebretsadik T, Shintani A, Huizinga MM, Davis D, Gregory RP, Malone R, Pignone M, DeWalt D, Elasy TA, Rothman RL

    Diabetes care   32 ( 12 )   2149 - 55   2009.12( ISSN:0149-5992

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.2337/dc09-0563

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  • Inflammatory mediators and premature coronary atherosclerosis in rheumatoid arthritis. Reviewed

    Rho YH, Chung CP, Oeser A, Solus J, Asanuma Y, Sokka T, Pincus T, Raggi P, Gebretsadik T, Shintani A, Stein CM

    Arthritis and rheumatism   61 ( 11 )   1580 - 5   2009.11( ISSN:0004-3591

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/art.25009

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  • Immortal time bias in critical care research: application of time-varying Cox regression for observational cohort studies. Reviewed

    Shintani AK, Girard TD, Eden SK, Arbogast PG, Moons KG, Ely EW

    Critical care medicine   37 ( 11 )   2939 - 45   2009.11( ISSN:0090-3493

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1097/CCM.0b013e3181b7fbbb

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  • Oral protein supplementation alone improves anabolism in a dose-dependent manner in chronic hemodialysis patients. Reviewed

    Sundell MB, Cavanaugh KL, Wu P, Shintani A, Hakim RM, Ikizler TA

    Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation   19 ( 5 )   412 - 21   2009.09( ISSN:1051-2276

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1053/j.jrn.2009.01.019

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  • Fluoroquinolone resistance in Mycobacterium tuberculosis: the effect of duration and timing of fluoroquinolone exposure. Reviewed

    Devasia RA, Blackman A, Gebretsadik T, Griffin M, Shintani A, May C, Smith T, Hooper N, Maruri F, Warkentin J, Mitchel E, Sterling TR

    American journal of respiratory and critical care medicine   180 ( 4 )   365 - 70   2009.08( ISSN:1073-449X

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    DOI: 10.1164/rccm.200901-0146OC

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  • Urine neutrophil gelatinase-associated lipocalin moderately predicts acute kidney injury in critically ill adults. Reviewed

    Siew ED, Ware LB, Gebretsadik T, Shintani A, Moons KG, Wickersham N, Bossert F, Ikizler TA

    Journal of the American Society of Nephrology : JASN   20 ( 8 )   1823 - 32   2009.08( ISSN:1046-6673

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1681/ASN.2008070673

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  • Adipocytokines are associated with radiographic joint damage in rheumatoid arthritis. Reviewed

    Rho YH, Solus J, Sokka T, Oeser A, Chung CP, Gebretsadik T, Shintani A, Pincus T, Stein CM

    Arthritis and rheumatism   60 ( 7 )   1906 - 14   2009.07( ISSN:0004-3591

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/art.24626

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  • Fluoroquinolone resistance in Mycobacterium tuberculosis: an assessment of MGIT 960, MODS and nitrate reductase assay and fluoroquinolone cross-resistance. Reviewed

    Devasia RA, Blackman A, May C, Eden S, Smith T, Hooper N, Maruri F, Stratton C, Shintani A, Sterling TR

    The Journal of antimicrobial chemotherapy   63 ( 6 )   1173 - 8   2009.06( ISSN:0305-7453

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/jac/dkp096

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  • Clinical factors associated with plasma F2-isoprostane levels in HIV-infected adults. Reviewed

    Redhage LA, Shintani A, Haas DW, Emeagwali N, Markovic M, Oboho I, Mwenya C, Erdem H, Acosta EP, Morrow JD, Hulgan T

    HIV clinical trials   10 ( 3 )   181 - 92   2009.05( ISSN:1528-4336

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    DOI: 10.1310/hct1003-181

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  • Determinants of plasma adiponectin levels in nondiabetic subjects with moderate to severe chronic kidney disease. Reviewed

    Ramos LF, Shintani A, Himmelfarb J, Ikizler TA

    Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation   19 ( 3 )   197 - 203   2009.05( ISSN:1051-2276

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1053/j.jrn.2009.01.028

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  • Derivation and validation of Spo2/Fio2 ratio to impute for Pao2/Fio2 ratio in the respiratory component of the Sequential Organ Failure Assessment score. Reviewed

    Pandharipande PP, Shintani AK, Hagerman HE, St Jacques PJ, Rice TW, Sanders NW, Ware LB, Bernard GR, Ely EW

    Critical care medicine   37 ( 4 )   1317 - 21   2009.04( ISSN:0090-3493

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1097/CCM.0b013e31819cefa9

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  • Associations between CYP2B6 polymorphisms and pharmacokinetics after a single dose of nevirapine or efavirenz in African americans. Reviewed

    Haas DW, Gebretsadik T, Mayo G, Menon UN, Acosta EP, Shintani A, Floyd M, Stein CM, Wilkinson GR

    The Journal of infectious diseases   199 ( 6 )   872 - 80   2009.03( ISSN:0022-1899

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1086/597125

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  • Presence of electroencephalogram burst suppression in sedated, critically ill patients is associated with increased mortality. Reviewed

    Watson PL, Shintani AK, Tyson R, Pandharipande PP, Pun BT, Ely EW

    Critical care medicine   36 ( 12 )   3171 - 7   2008.12( ISSN:0090-3493

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1097/CCM.0b013e318186b9ce

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  • Amino-terminal fragment of the prohormone brain-type natriuretic peptide in rheumatoid arthritis. Reviewed

    Solus J, Chung CP, Oeser A, Avalos I, Gebretsadik T, Shintani A, Raggi P, Sokka T, Pincus T, Stein CM

    Arthritis and rheumatism   58 ( 9 )   2662 - 9   2008.09( ISSN:0004-3591

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/art.23796

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  • beta(2)-adrenergic receptor promoter haplotype influences spirometric response during an acute asthma exacerbation. Reviewed

    Moore PE, Williams SM, Gebretsadik T, Jiang L, Minton PL, Shintani A, Phillips Iii JA, Dawson EP, Hartert TV

    Clinical and translational science   1 ( 2 )   155 - 61   2008.09( ISSN:1752-8054

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/j.1752-8062.2008.00036.x

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  • Novel cardiovascular risk factors in premature coronary atherosclerosis associated with systemic lupus erythematosus. Reviewed

    Rho YH, Chung CP, Oeser A, Solus J, Raggi P, Gebretsadik T, Shintani A, Stein CM

    The Journal of rheumatology   35 ( 9 )   1789 - 94   2008.09( ISSN:0315-162X

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  • Novel cardiovascular risk factors in premature coronary atherosclerosis associated with systemic lupus erythematosus. Reviewed

    Rho YH, Chung CP, Oeser A, Solus J, Raggi P, Gebretsadik T, Shintani A, Stein CM

    The Journal of rheumatology   35 ( 9 )   1789 - 94   2008.09( ISSN:0315-162X

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  • Insulin use and weight maintenance in well-controlled type 2 diabetes: a prospective cohort study. Reviewed

    Huizinga MM, Niswender KD, Gebretsadik T, Rothman RL, Shintani AK, Elasy TA

    Obesity (Silver Spring, Md.)   16 ( 8 )   1933 - 7   2008.08( ISSN:1930-7381

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/oby.2008.301

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  • Effects of C-reactive Protein and Homocysteine on Cytokine Production: Modulation by Pravastatin. Reviewed

    Asanuma Y, Oeser A, Stanley E, Bailey DG, Shintani A, Stein CM

    Archives of drug information   1 ( 1 )   14 - 22   2008.07

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/j.1753-5174.2007.00003.x

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  • Prevalence and risk factors for development of delirium in surgical and trauma intensive care unit patients. Reviewed

    Pandharipande P, Cotton BA, Shintani A, Thompson J, Pun BT, Morris JA Jr, Dittus R, Ely EW

    The Journal of trauma   65 ( 1 )   34 - 41   2008.07( ISSN:0022-5282

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1097/TA.0b013e31814b2c4d

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  • Inflammation-associated insulin resistance: differential effects in rheumatoid arthritis and systemic lupus erythematosus define potential mechanisms. Reviewed

    Chung CP, Oeser A, Solus JF, Gebretsadik T, Shintani A, Avalos I, Sokka T, Raggi P, Pincus T, Stein CM

    Arthritis and rheumatism   58 ( 7 )   2105 - 12   2008.07( ISSN:0004-3591

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/art.23600

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  • Association of numeracy and diabetes control. Reviewed

    Cavanaugh K, Huizinga MM, Wallston KA, Gebretsadik T, Shintani A, Davis D, Gregory RP, Fuchs L, Malone R, Cherrington A, Pignone M, DeWalt DA, Elasy TA, Rothman RL

    Annals of internal medicine   148 ( 10 )   737 - 46   2008.05( ISSN:0003-4819

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.7326/0003-4819-148-10-200805200-00006

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  • Determinants of C-reactive protein in chronic hemodialysis patients: relevance of dialysis catheter utilization. Reviewed

    Hung A, Pupim L, Yu C, Shintani A, Siew E, Ayus C, Hakim RM, Ikizler TA

    Hemodialysis international. International Symposium on Home Hemodialysis   12 ( 2 )   236 - 43   2008.04( ISSN:1492-7535

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/j.1542-4758.2008.00260.x

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  • Waist circumference, not the metabolic syndrome, predicts glucose deterioration in type 2 diabetes. Reviewed

    Blaha MJ, Gebretsadik T, Shintani A, Elasy TA

    Obesity (Silver Spring, Md.)   16 ( 4 )   869 - 74   2008.04( ISSN:1930-7381

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/oby.2008.12

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  • Self-management behaviors, racial disparities, and glycemic control among adolescents with type 2 diabetes. Reviewed

    Rothman RL, Mulvaney S, Elasy TA, VanderWoude A, Gebretsadik T, Shintani A, Potter A, Russell WE, Schlundt D

    Pediatrics   121 ( 4 )   e912 - 9   2008.04( ISSN:0031-4005

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1542/peds.2007-1484

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  • Oxidative stress and inflammation are associated with adiposity in moderate to severe CKD. Reviewed

    Ramos LF, Shintani A, Ikizler TA, Himmelfarb J

    Journal of the American Society of Nephrology : JASN   19 ( 3 )   593 - 9   2008.03( ISSN:1046-6673

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1681/ASN.2007030355

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  • Prevalence of the metabolic syndrome is increased in rheumatoid arthritis and is associated with coronary atherosclerosis. Reviewed

    Chung CP, Oeser A, Solus JF, Avalos I, Gebretsadik T, Shintani A, Raggi P, Sokka T, Pincus T, Stein CM

    Atherosclerosis   196 ( 2 )   756 - 63   2008.02( ISSN:0021-9150

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.atherosclerosis.2007.01.004

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  • Efficacy and safety of a paired sedation and ventilator weaning protocol for mechanically ventilated patients in intensive care (Awakening and Breathing Controlled trial): a randomised controlled trial. Reviewed

    Girard TD, Kress JP, Fuchs BD, Thomason JW, Schweickert WD, Pun BT, Taichman DB, Dunn JG, Pohlman AS, Kinniry PA, Jackson JC, Canonico AE, Light RW, Shintani AK, Thompson JL, Gordon SM, Hall JB, Dittus RS, Bernard GR, Ely EW

    Lancet (London, England)   371 ( 9607 )   126 - 34   2008.01( ISSN:0140-6736

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/S0140-6736(08)60105-1

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  • Effect of sedation with dexmedetomidine vs lorazepam on acute brain dysfunction in mechanically ventilated patients: the MENDS randomized controlled trial. Reviewed

    Pandharipande PP, Pun BT, Herr DL, Maze M, Girard TD, Miller RR, Shintani AK, Thompson JL, Jackson JC, Deppen SA, Stiles RA, Dittus RS, Bernard GR, Ely EW

    JAMA   298 ( 22 )   2644 - 53   2007.12( ISSN:0098-7484

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1001/jama.298.22.2644

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  • Serum osteoprotegerin is increased and independently associated with coronary-artery atherosclerosis in patients with rheumatoid arthritis. Reviewed

    Asanuma Y, Chung CP, Oeser A, Solus JF, Avalos I, Gebretsadik T, Shintani A, Raggi P, Sokka T, Pincus T, Stein CM

    Atherosclerosis   195 ( 2 )   e135 - 41   2007.12( ISSN:0021-9150

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.atherosclerosis.2007.04.049

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  • Prognostic significance of FLT3 internal tandem duplication and NPM1 mutations in acute myeloid leukemia in an unselected patient population. Reviewed

    Suzuki R, Onizuka M, Kojima M, Shimada M, Okamura K, Fukagawa S, Tsuboi K, Kikuchi A, Kobayashi H, Shintani A, Ogawa Y, Kawada H, Hotta T, Ando K

    International journal of hematology   86 ( 5 )   422 - 8   2007.12( ISSN:0925-5710

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/bf02984000

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  • Body mass index and fat mass are the primary correlates of insulin resistance in nondiabetic stage 3-4 chronic kidney disease patients. Reviewed

    Trirogoff ML, Shintani A, Himmelfarb J, Ikizler TA

    The American journal of clinical nutrition   86 ( 6 )   1642 - 8   2007.12( ISSN:0002-9165

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/ajcn/86.5.1642

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  • Increased augmentation index in rheumatoid arthritis and its relationship to coronary artery atherosclerosis. Reviewed

    Avalos I, Chung CP, Oeser A, Gebretsadik T, Shintani A, Kurnik D, Raggi P, Sokka T, Pincus T, Stein CM

    The Journal of rheumatology   34 ( 12 )   2388 - 94   2007.12( ISSN:0315-162X

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    Publishing type:Research paper (scientific journal)  

    PubMed

  • Increased augmentation index in rheumatoid arthritis and its relationship to coronary artery atherosclerosis. Reviewed

    Avalos I, Chung CP, Oeser A, Gebretsadik T, Shintani A, Kurnik D, Raggi P, Sokka T, Pincus T, Stein CM

    The Journal of rheumatology   34 ( 12 )   2388 - 94   2007.12( ISSN:0315-162X

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  • Early intervention improves mortality and hospitalization rates in incident hemodialysis patients: RightStart program. Reviewed

    Wingard RL, Pupim LB, Krishnan M, Shintani A, Ikizler TA, Hakim RM

    Clinical journal of the American Society of Nephrology : CJASN   2 ( 6 )   1170 - 5   2007.11( ISSN:1555-9041

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.2215/CJN.04261206

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  • A cost analysis of colonoscopy using microcosting and time-and-motion techniques. Reviewed

    Henry SG, Ness RM, Stiles RA, Shintani AK, Dittus RS

    Journal of general internal medicine   22 ( 10 )   1415 - 21   2007.10( ISSN:0884-8734

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s11606-007-0281-6

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  • Immune function in young children with previous pulmonary or miliary/meningeal tuberculosis and impact of BCG vaccination. Reviewed

    Sterling TR, Martire T, de Almeida AS, Ding L, Greenberg DE, Moreira LA, Elloumi H, Torres AP, Sant'Anna CC, Calazans E, Paraguassu G, Gebretsadik T, Shintani A, Miller K, Kritski A, Lapa e Silva JR, Holland SM

    Pediatrics   120 ( 4 )   e912 - 21   2007.10( ISSN:0031-4005

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1542/peds.2006-3150

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  • Motoric subtypes of delirium in mechanically ventilated surgical and trauma intensive care unit patients. Reviewed

    Pandharipande P, Cotton BA, Shintani A, Thompson J, Costabile S, Truman Pun B, Dittus R, Ely EW

    Intensive care medicine   33 ( 10 )   1726 - 31   2007.10( ISSN:0342-4642

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00134-007-0687-y

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  • Changes in urinary dinor dihydro F(2)-isoprostane metabolite concentrations, a marker of oxidative stress, during and following asthma exacerbations. Reviewed

    Wu P, Roberts LJ 2nd, Shintani AK, Sheller JR, Minton PA, Higgins SB, Hartert TV

    Free radical research   41 ( 9 )   956 - 62   2007.09( ISSN:1071-5762

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1080/10715760701444600

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  • Preferential hypermethylation of the Dickkopf-1 promoter in core-binding factor leukaemia. Reviewed

    Suzuki R, Onizuka M, Kojima M, Shimada M, Fukagawa S, Tsuboi K, Kobayashi H, Shintani A, Ogawa Y, Kawada H, Hotta T, Ando K

    British journal of haematology   138 ( 5 )   624 - 31   2007.09( ISSN:0007-1048

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/j.1365-2141.2007.06702.x

    PubMed

  • Clinical sedation scores as indicators of sedative and analgesic drug exposure in intensive care unit patients. Reviewed

    Masica AL, Girard TD, Wilkinson GR, Thomason JW, Truman Pun B, Nair UB, Light RW, Canonico AE, Dunn J, Pandharipande P, Shintani AK, Ely EW

    The American journal of geriatric pharmacotherapy   5 ( 3 )   218 - 31   2007.09( ISSN:1543-5946

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.amjopharm.2007.10.005

    PubMed

  • Inflammatory mechanisms affecting the lipid profile in patients with systemic lupus erythematosus. Reviewed

    Chung CP, Oeser A, Solus J, Avalos I, Gebretsadik T, Shintani A, Linton MF, Fazio S, Stein CM

    The Journal of rheumatology   34 ( 9 )   1849 - 54   2007.09( ISSN:0315-162X

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    PubMed

  • Comment on "Incidence, risk factors and consequences of ICU delirium" by Ouimet et al. Reviewed

    Girard TD, Shintani AK, Ely EW

    Intensive care medicine   33 ( 8 )   1479 - 80; author reply 1481   2007.08( ISSN:0342-4642

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00134-007-0698-8

    PubMed

  • Bradykinin B(2) receptor does not contribute to blood pressure lowering during AT(1) receptor blockade. Reviewed

    LeFebvre J, Shintani A, Gebretsadik T, Petro JR, Murphey LJ, Brown NJ

    The Journal of pharmacology and experimental therapeutics   320 ( 3 )   1261 - 7   2007.03( ISSN:0022-3565

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1124/jpet.106.117259

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  • Evaluation of a 12-week home-based walking intervention for breast cancer survivors. Reviewed

    Matthews CE, Wilcox S, Hanby CL, Der Ananian C, Heiney SP, Gebretsadik T, Shintani A

    Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer   15 ( 2 )   203 - 11   2007.02( ISSN:0941-4355

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00520-006-0122-x

    PubMed

  • High prevalence of the metabolic syndrome in patients with systemic lupus erythematosus: association with disease characteristics and cardiovascular risk factors. Reviewed

    Chung CP, Avalos I, Oeser A, Gebretsadik T, Shintani A, Raggi P, Stein CM

    Annals of the rheumatic diseases   66 ( 2 )   208 - 14   2007.02( ISSN:0003-4967

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1136/ard.2006.054973

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  • Apolipoprotein E4 polymorphism as a genetic predisposition to delirium in critically ill patients. Reviewed

    Ely EW, Girard TD, Shintani AK, Jackson JC, Gordon SM, Thomason JW, Pun BT, Canonico AE, Light RW, Pandharipande P, Laskowitz DT

    Critical care medicine   35 ( 1 )   112 - 7   2007.01( ISSN:0090-3493

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1097/01.CCM.0000251925.18961.CA

    PubMed

  • Risk factors for post-traumatic stress disorder symptoms following critical illness requiring mechanical ventilation: a prospective cohort study. Reviewed

    Girard TD, Shintani AK, Jackson JC, Gordon SM, Pun BT, Henderson MS, Dittus RS, Bernard GR, Ely EW

    Critical care (London, England)   11 ( 1 )   R28   2007( ISSN:1364-8535

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/cc5708

    PubMed

  • Patient understanding of food labels: the role of literacy and numeracy. Reviewed

    Rothman RL, Housam R, Weiss H, Davis D, Gregory R, Gebretsadik T, Shintani A, Elasy TA

    American journal of preventive medicine   31 ( 5 )   391 - 8   2006.11( ISSN:0749-3797

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.amepre.2006.07.025

    PubMed

  • A randomized controlled trial to prevent glycemic relapse in longitudinal diabetes care: study protocol (NCT00362193). Reviewed

    Huizinga MM, Shintani A, Michon S, Brown A, Wolff K, Shackleford L, King EB, Gregory RP, Davis D, Stiles R, Gebretsadik T, Chen K, Rothman R, Pichert JW, Schlundt D, Elasy TA

    Implementation science : IS   1 ( 1 )   24   2006.10

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/1748-5908-1-24

    PubMed

  • Low CD4+ T cell nadir is an independent predictor of lower HIV-specific immune responses in chronically HIV-1-infected subjects receiving highly active antiretroviral therapy. Reviewed

    Siddique MA, Hartman KE, Dragileva E, Dondero M, Gebretsadik T, Shintani A, Peiperl L, Valentine F, Kalams SA

    The Journal of infectious diseases   194 ( 5 )   661 - 5   2006.09( ISSN:0022-1899

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1086/505913

    PubMed

  • Diabetes, inflammation, and functional decline in older adults: findings from the Health, Aging and Body Composition (ABC) study. Reviewed

    Figaro MK, Kritchevsky SB, Resnick HE, Shorr RI, Butler J, Shintani A, Penninx BW, Simonsick EM, Goodpaster BH, Newman AB, Schwartz AV, Harris TB

    Diabetes care   29 ( 9 )   2039 - 45   2006.09( ISSN:0149-5992

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.2337/dc06-0245

    PubMed

  • Smoking rates among pregnant women in Tennessee, 1990-2001. Reviewed

    Whalen U, Griffin MR, Shintani A, Mitchel E, Cruz-Gervis R, Forbes BL, Hartert TV

    Preventive medicine   43 ( 3 )   196 - 9   2006.09( ISSN:0091-7435

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.ypmed.2006.04.021

    PubMed

  • Cessation of asthma medication in early pregnancy. Reviewed

    Enriquez R, Wu P, Griffin MR, Gebretsadik T, Shintani A, Mitchel E, Carroll KN, Hartert TV

    American journal of obstetrics and gynecology   195 ( 1 )   149 - 53   2006.07( ISSN:0002-9378

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.ajog.2006.01.065

    PubMed

  • The relationship of rhinovirus-associated asthma hospitalizations with inhaled corticosteroids and smoking. Reviewed

    Venarske DL, Busse WW, Griffin MR, Gebretsadik T, Shintani AK, Minton PA, Peebles RS, Hamilton R, Weisshaar E, Vrtis R, Higgins SB, Hartert TV

    The Journal of infectious diseases   193 ( 11 )   1536 - 43   2006.06( ISSN:0022-1899

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1086/503809

    PubMed

  • Decreased CD4+ lymphocytes and innate immune responses in adults with previous extrapulmonary tuberculosis. Reviewed

    Antas PR, Ding L, Hackman J, Reeves-Hammock L, Shintani AK, Schiffer J, Holland SM, Sterling TR

    The Journal of allergy and clinical immunology   117 ( 4 )   916 - 23   2006.04( ISSN:0091-6749

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.jaci.2006.01.042

    PubMed

  • Delirium and its motoric subtypes: a study of 614 critically ill patients. Reviewed

    Peterson JF, Pun BT, Dittus RS, Thomason JW, Jackson JC, Shintani AK, Ely EW

    Journal of the American Geriatrics Society   54 ( 3 )   479 - 84   2006.03( ISSN:0002-8614

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/j.1532-5415.2005.00621.x

    PubMed

  • Glycemic relapse in type 2 diabetes. Reviewed

    Graber AL, Shintani AK, Wolff K, Brown A, Elasy TA

    Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists   12 ( 2 )   145 - 51   2006.03( ISSN:1530-891X

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.4158/EP.12.2.145

    PubMed

  • Increased concentration of proatherogenic inflammatory cytokines in systemic lupus erythematosus: relationship to cardiovascular risk factors. Reviewed

    Asanuma Y, Chung CP, Oeser A, Shintani A, Stanley E, Raggi P, Stein CM

    The Journal of rheumatology   33 ( 3 )   539 - 45   2006.03( ISSN:0315-162X

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    Publishing type:Research paper (scientific journal)  

    PubMed

  • Increased concentration of proatherogenic inflammatory cytokines in systemic lupus erythematosus: relationship to cardiovascular risk factors. Reviewed

    Asanuma Y, Chung CP, Oeser A, Shintani A, Stanley E, Raggi P, Stein CM

    The Journal of rheumatology   33 ( 3 )   539 - 45   2006.03( ISSN:0315-162X

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    Publishing type:Research paper (scientific journal)  

  • Suppression of dynamic Ca(2+) transient responses to pacing in ventricular myocytes from mice with genetic calmodulin kinase II inhibition. Reviewed

    Wu Y, Shintani A, Grueter C, Zhang R, Hou Y, Yang J, Kranias EG, Colbran RJ, Anderson ME

    Journal of molecular and cellular cardiology   40 ( 2 )   213 - 23   2006.02( ISSN:0022-2828

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.yjmcc.2005.11.005

    PubMed

  • Lorazepam is an independent risk factor for transitioning to delirium in intensive care unit patients. Reviewed

    Pandharipande P, Shintani A, Peterson J, Pun BT, Wilkinson GR, Dittus RS, Bernard GR, Ely EW

    Anesthesiology   104 ( 1 )   21 - 6   2006.01( ISSN:0003-3022

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1097/00000542-200601000-00005

    PubMed

  • Utility of the Framingham risk score to predict the presence of coronary atherosclerosis in patients with rheumatoid arthritis. Reviewed

    Chung CP, Oeser A, Avalos I, Gebretsadik T, Shintani A, Raggi P, Sokka T, Pincus T, Stein CM

    Arthritis research & therapy   8 ( 6 )   R186   2006( ISSN:1478-6354

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/ar2098

    PubMed

  • Increased coronary-artery atherosclerosis in rheumatoid arthritis: relationship to disease duration and cardiovascular risk factors. Reviewed

    Chung CP, Oeser A, Raggi P, Gebretsadik T, Shintani AK, Sokka T, Pincus T, Avalos I, Stein CM

    Arthritis and rheumatism   52 ( 10 )   3045 - 53   2005.10( ISSN:0004-3591

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/art.21288

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  • Intensive care unit delirium is an independent predictor of longer hospital stay: a prospective analysis of 261 non-ventilated patients. Reviewed

    Thomason JW, Shintani A, Peterson JF, Pun BT, Jackson JC, Ely EW

    Critical care (London, England)   9 ( 4 )   R375 - 81   2005.08( ISSN:1364-8535

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/cc3729

    PubMed

  • Racial differences in asthma morbidity during pregnancy. Reviewed

    Carroll KN, Griffin MR, Gebretsadik T, Shintani A, Mitchel E, Hartert TV

    Obstetrics and gynecology   106 ( 1 )   66 - 72   2005.07( ISSN:0029-7844

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1097/01.AOG.0000164471.87157.4c

    PubMed

  • Large-scale implementation of sedation and delirium monitoring in the intensive care unit: a report from two medical centers. Reviewed

    Pun BT, Gordon SM, Peterson JF, Shintani AK, Jackson JC, Foss J, Harding SD, Bernard GR, Dittus RS, Ely EW

    Critical care medicine   33 ( 6 )   1199 - 205   2005.06( ISSN:0090-3493

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1097/01.ccm.0000166867.78320.ac

    PubMed

  • Pseudovirion particle production by live poxvirus human immunodeficiency virus vaccine vector enhances humoral and cellular immune responses. Reviewed

    Chen X, Rock MT, Hammonds J, Tartaglia J, Shintani A, Currier J, Slike B, Crowe JE Jr, Marovich M, Spearman P

    Journal of virology   79 ( 9 )   5537 - 47   2005.05( ISSN:0022-538X

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1128/JVI.79.9.5537-5547.2005

    PubMed

  • A randomized trial of a primary care-based disease management program to improve cardiovascular risk factors and glycated hemoglobin levels in patients with diabetes. Reviewed

    Rothman RL, Malone R, Bryant B, Shintani AK, Crigler B, Dewalt DA, Dittus RS, Weinberger M, Pignone MP

    The American journal of medicine   118 ( 3 )   276 - 84   2005.03( ISSN:0002-9343

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.amjmed.2004.09.017

    PubMed

  • Endothelial function in systemic lupus erythematosus: relationship to disease activity, cardiovascular risk factors, corticosteroid therapy, and coronary calcification. Reviewed

    Turner E, Dishy V, Chung CP, Harris P, Pierces R, Asanuma Y, Oeser A, Gebretsadik T, Shintani A, Raggi P, Stein CM

    Vascular health and risk management   1 ( 4 )   357 - 60   2005( ISSN:1176-6344

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.2147/vhrm.2005.1.4.357

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Books and Other Publications

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MISC

  • 2022年JCSガイドラインフォーカスアップデート版 安定冠動脈疾患の診断と治療(JCS 2022 Guideline Focused Update on Diagnosis and Treatment in Patients With Stable Coronary Artery Disease)

    Nakano Shintaro, Kohsaka Shun, Chikamori Taishiro, Fukushima Kenji, Kobayashi Yoshio, Kozuma Ken, Manabe Susumu, Matsuo Hitoshi, Nakamura Masato, Ohno Takayuki, Sawano Mitsuaki, Toda Koichi, Ueda Yasunori, Yokoi Hiroyoshi, Gatate Yodo, Kasai Tokuo, Kawase Yoshiaki, Matsumoto Naoya, Mori Hitoshi, Nakazato Ryo, Niimi Nozomi, Saito Yuichi, Shintani Ayumi, Watanabe Ippei, Watanabe Yusuke, Ikari Yuji, Jinzaki Masahiro, Kosuge Masami, Nakajima Kenichi, Kimura Takeshi, the JCS Joint Working Group

    Circulation Journal   86 ( 5 )   882 - 915   2022.04( ISSN:1346-9843

  • 医療統計学リテラシー 正しい比較とは? リンゴとミカンを比べていないだろうか?

    新谷 歩

    日本歯科医師会雑誌   74 ( 12 )   1074 - 1075   2022.03( ISSN:0047-1763

  • 人間と科学(第332回) 医療統計学リテラシー 正しい統計検定手法の選び方

    新谷 歩

    日本歯科医師会雑誌   74 ( 11 )   994 - 995   2022.02( ISSN:0047-1763

  • 人間と科学(第331回) 医療統計学リテラシー リスクの計算

    新谷 歩

    日本歯科医師会雑誌   74 ( 10 )   914 - 915   2022.01( ISSN:0047-1763

  • 人間と科学(第330回) 医療統計学リテラシー オッズ比とリスク比

    新谷 歩

    日本歯科医師会雑誌   74 ( 9 )   834 - 835   2021.12( ISSN:0047-1763

  • 【図解 分子メカニズムから理解する婦人科がんの薬物療法】総論 臨床試験および薬事承認を理解するために必要な基礎知識 臨床試験結果を正しく理解するための統計学の基礎知識

    新谷 歩

    産婦人科の実際   70 ( 12 )   1428 - 1434   2021.11( ISSN:0558-4728

  • 人間と科学(第329回) 医療統計学リテラシー P値と仮説検定

    新谷 歩

    日本歯科医師会雑誌   74 ( 8 )   754 - 755   2021.11( ISSN:0047-1763

  • 【脳卒中治療に必要な基礎知識】大規模臨床試験を理解するうえで必要な統計的基礎知識

    新谷 歩

    BRAIN and NERVE: 神経研究の進歩   73 ( 9 )   0999 - 1006   2021.09( ISSN:1881-6096

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    <文献概要>臨床試験のエビデンスを理解するためには,統計学の知識が不可欠である。本論では,盲検化,FAS-ITTの原則,事前に指定されたエンドポイント,サブグループ解析,欠損値の扱い方,サンプルサイズの計算,グローバルスタディの適用性,非劣性試験,メタアナリシスについて説明する。また,最近行われたアルツハイマー病治療薬としてのaducanumabの大規模臨床試験の統計的側面についても解説する。

  • パンデミック下での国際臨床研究プラットフォームへの参加はなぜ重要か 日本で始まったREMAP-CAP(Why participation in an international clinical trial platform matters during a pandemic? Launching REMAP-CAP in Japan)

    Kamata Kazuhiro, Jindai Kazuaki, Ichihara Nao, Saito Hiroki, Kato Hideaki, Kunishima Hiroyuki, Shintani Ayumi, Nishida Osamu, Fujitani Shigeki

    Journal of Intensive Care   9   1 of 3 - 3 of 3   2021.04

  • 臨床研究におけるREDCapの活用

    新谷 歩, 太田 恵子

    腫瘍内科   27 ( 4 )   497 - 502   2021.04( ISSN:1881-6568

  • 臨床研究を成功させるデータの集め方

    新谷 歩

    循環器内科   88 ( 4 )   478 - 482   2020.10( ISSN:1884-2909

  • 入門講座 医療統計ことはじめ 介入研究のデザインとデータ解析

    新谷 歩

    総合リハビリテーション   48 ( 6 )   557 - 562   2020.06( ISSN:0386-9822

  • 入門講座 医療統計ことはじめ 観察研究のデザインとデータ解析 多変量解析と傾向スコア

    新谷 歩

    総合リハビリテーション   48 ( 5 )   465 - 470   2020.05( ISSN:0386-9822

  • 入門講座 医療統計ことはじめ 疫学研究デザインと記述研究に用いられる統計解析 単変量解析

    新谷 歩

    総合リハビリテーション   48 ( 4 )   355 - 361   2020.04( ISSN:0386-9822

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    <文献概要>はじめに 「さあ臨床研究を始めよう!」と思ったら,まずはどういった研究が考えられるのか,研究の分類について理解することが重要です.研究は大きく分けて実験的介入研究と観察研究に区分されます.

  • 整形外科治療の費用対効果 費用対効果の評価方法の基本 Reviewed

    加葉田 大志朗, 新谷 歩

    (株)医学書院 臨床整形外科   54 ( 8 )   767 - 770   2019.08( ISSN:0557-0433

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    Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

    <文献概要>近年,日本の国民医療費は増加の一途をたどり,非常に高額な新規薬剤なども上市されるなか,日常臨床における治療の効果のみでなく,その費用対効果も注目される機会が増えてきた.費用対効果を評価するための指標は種々提案されているが,従来は,新規治療によって得られた効果量について,その効果量を1単位得るために必要となる費用として計算できる,増分費用対効果比(incremental cost effectiveness ratio:ICER)が利用されることが多い.本稿においてはそのICERの基本的な計算方法や,得られた結果を解釈する際の注意点などについて紹介する.

  • 整形外科治療の費用対効果 費用対効果の評価方法の基本 Reviewed

    加葉田 大志朗, 新谷 歩

    (株)医学書院 臨床整形外科   54 ( 8 )   767 - 770   2019.08( ISSN:0557-0433

     More details

    Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

    <文献概要>近年,日本の国民医療費は増加の一途をたどり,非常に高額な新規薬剤なども上市されるなか,日常臨床における治療の効果のみでなく,その費用対効果も注目される機会が増えてきた.費用対効果を評価するための指標は種々提案されているが,従来は,新規治療によって得られた効果量について,その効果量を1単位得るために必要となる費用として計算できる,増分費用対効果比(incremental cost effectiveness ratio:ICER)が利用されることが多い.本稿においてはそのICERの基本的な計算方法や,得られた結果を解釈する際の注意点などについて紹介する.

  • 【救急医学研究 入門!】救急医学研究の行い方入門 統計学的検討について Reviewed

    加葉田 大志朗, 新谷 歩

    (株)へるす出版 救急医学   43 ( 3 )   269 - 276   2019.03( ISSN:0385-8162

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    Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 観察研究データの解析 Reviewed

    加葉田 大志朗, 新谷 歩

    (一社)日本ペインクリニック学会 日本ペインクリニック学会誌   26 ( 1 )   1 - 6   2019.02( ISSN:1340-4903

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    Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

    治療などの介入を研究対象者へ無作為(ランダム)に割り付けるランダム化比較試験(randomized control trial:RCT)では、介入群と対照群の背景因子は平均的に似通ったものとなる。日常臨床では治療を行うかどうかは臨床的判断によるため、各群への割り付けには一定の傾向が生じることが多い。そのため日常臨床から得られたデータのみを利用する観察研究においては、この治療を受ける傾向によって比較群間で背景因子に差異が生じてしまう。この背景因子の違いによってアウトカムの群間比較の結果にバイアスが生じることを交絡と呼び、観察研究ではこの交絡への対処が必須となる。交絡への基本的な統計的対処方法としては多変量回帰分析が利用されている。多変量回帰分析では介入因子以外の背景情報についても考慮することができるため、それらのアウトカムへの影響を差し引いた介入効果を推定できる。また多変量回帰分析と並んで、交絡への対処方法として広く活用されるようになった傾向スコア手法とあわせてその概要を紹介する。加えて、これらの手法について医学研究における不適切な利用が指摘されることもあるため、本稿ではその利用方法に関する基本的な注意事項についても言及する。(著者抄録)

  • 観察研究データの解析

    加葉田 大志朗, 新谷 歩

    日本ペインクリニック学会誌   26 ( 1 )   1 - 6   2019.02( ISSN:1340-4903

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    治療などの介入を研究対象者へ無作為(ランダム)に割り付けるランダム化比較試験(randomized control trial:RCT)では、介入群と対照群の背景因子は平均的に似通ったものとなる。日常臨床では治療を行うかどうかは臨床的判断によるため、各群への割り付けには一定の傾向が生じることが多い。そのため日常臨床から得られたデータのみを利用する観察研究においては、この治療を受ける傾向によって比較群間で背景因子に差異が生じてしまう。この背景因子の違いによってアウトカムの群間比較の結果にバイアスが生じることを交絡と呼び、観察研究ではこの交絡への対処が必須となる。交絡への基本的な統計的対処方法としては多変量回帰分析が利用されている。多変量回帰分析では介入因子以外の背景情報についても考慮することができるため、それらのアウトカムへの影響を差し引いた介入効果を推定できる。また多変量回帰分析と並んで、交絡への対処方法として広く活用されるようになった傾向スコア手法とあわせてその概要を紹介する。加えて、これらの手法について医学研究における不適切な利用が指摘されることもあるため、本稿ではその利用方法に関する基本的な注意事項についても言及する。(著者抄録)

  • 観察研究データの解析 Reviewed

    加葉田 大志朗, 新谷 歩

    (一社)日本ペインクリニック学会 日本ペインクリニック学会誌   26 ( 1 )   1 - 6   2019.02( ISSN:1340-4903

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    Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

    治療などの介入を研究対象者へ無作為(ランダム)に割り付けるランダム化比較試験(randomized control trial:RCT)では、介入群と対照群の背景因子は平均的に似通ったものとなる。日常臨床では治療を行うかどうかは臨床的判断によるため、各群への割り付けには一定の傾向が生じることが多い。そのため日常臨床から得られたデータのみを利用する観察研究においては、この治療を受ける傾向によって比較群間で背景因子に差異が生じてしまう。この背景因子の違いによってアウトカムの群間比較の結果にバイアスが生じることを交絡と呼び、観察研究ではこの交絡への対処が必須となる。交絡への基本的な統計的対処方法としては多変量回帰分析が利用されている。多変量回帰分析では介入因子以外の背景情報についても考慮することができるため、それらのアウトカムへの影響を差し引いた介入効果を推定できる。また多変量回帰分析と並んで、交絡への対処方法として広く活用されるようになった傾向スコア手法とあわせてその概要を紹介する。加えて、これらの手法について医学研究における不適切な利用が指摘されることもあるため、本稿ではその利用方法に関する基本的な注意事項についても言及する。(著者抄録)

  • 国際誌にアクセプトを目指して 統計チェックリスト Reviewed

    加葉田 大志朗, 新谷 歩

    克誠堂出版(株) 麻酔   67 ( 増刊 )   S226 - S233   2018.11( ISSN:0021-4892

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  • 国際誌にアクセプトを目指して 統計チェックリスト Reviewed

    加葉田 大志朗, 新谷 歩

    克誠堂出版(株) 麻酔   67 ( 増刊 )   S226 - S233   2018.11( ISSN:0021-4892

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  • 接着強さ測定値のばらつきを軽減する高度な統計分析(Advanced statistical analyses to reduce inconsistency of bond strength data) Reviewed

    南野 卓也, 峯 篤史, 新谷 歩, 東 真未, 川口 明日香[上村], 壁谷 知茂, 萩野 僚介, 今井 大, 田尻 裕子, 松本 真理子, 矢谷 博文

    大阪大学歯学会 大阪大学歯学雑誌   63 ( 1 )   5 - 7   2018.10( ISSN:0473-4629

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  • 接着強さ測定値のばらつきを軽減する高度な統計分析(Advanced statistical analyses to reduce inconsistency of bond strength data) Reviewed

    南野 卓也, 峯 篤史, 新谷 歩, 東 真未, 川口 明日香, 壁谷 知茂, 萩野 僚介, 今井 大, 田尻 裕子, 松本 真理子, 矢谷 博文

    大阪大学歯学会 大阪大学歯学雑誌   63 ( 1 )   5 - 7   2018.10( ISSN:0473-4629

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  • ビッグデータの解析手法 多変量解析と傾向スコア Reviewed

    加葉田 大志朗, 新谷 歩

    (一社)日本糖尿病・妊娠学会 糖尿病と妊娠   18 ( 2 )   S - 57   2018.08( ISSN:1347-9172

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    最近では電子カルテや医療デバイスの普及により、医療分野に関しても日常臨床や日常生活に関するビッグデータが収集・活用される機会が増えてきた。これらの日常的に得られたデータを扱う際には、種々のバイアスへの対処が必要となる。とくに比較群間の背景が異なることで群間比較の結果にバイアスを生じさせる交絡については、統計解析による対策がほぼ必須となる。本稿ではこの交絡の対策として一般的に利用されることが多い多変量回帰分析と、近年医学分野でも幅広く利用されるようになった傾向スコア手法について、基本的な事項を紹介する。(著者抄録)

  • 我が国における臨床研究支援基盤構築 人材育成とITインフラ整備が喫緊の課題 Reviewed

    新谷 歩

    大阪市医学会 大阪市医学会雑誌   66   7 - 11   2017.12( ISSN:0386-4103

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    Publishing type:Article, review, commentary, editorial, etc. (scientific journal)   Kind of work:Single Work  

    臨床研究の科学的妥当性を担保するためには生物統計家の関与が必須である。しかし、わが国では生物統計家が不足している中、アカデミア臨床研究センターにおける研究データ関連基盤も充実しているとは言い難い。そのような背景から起こった度重なる研究不正を受け、来年いよいよ臨床研究法が施行される。基盤整備の追い付かない中、臨床研究はより高いスタンダードでの実施を必須とされる。本総説では、わが国の臨床研究における生物統計家の重要性と大阪市立大学大学院医学研究科修士コースにおける人材育成の取り組みと、大阪市立大学医学部附属病院臨床研究・イノベーション推進センターにおいて、本年より運用を開始した研究データ収集システムであるresearch electronic data capture(REDCap)について紹介する。(著者抄録)

  • 我が国における臨床研究支援基盤構築 人材育成とITインフラ整備が喫緊の課題 Reviewed

    新谷 歩

    大阪市医学会 大阪市医学会雑誌   66   7 - 11   2017.12( ISSN:0386-4103

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    臨床研究の科学的妥当性を担保するためには生物統計家の関与が必須である。しかし、わが国では生物統計家が不足している中、アカデミア臨床研究センターにおける研究データ関連基盤も充実しているとは言い難い。そのような背景から起こった度重なる研究不正を受け、来年いよいよ臨床研究法が施行される。基盤整備の追い付かない中、臨床研究はより高いスタンダードでの実施を必須とされる。本総説では、わが国の臨床研究における生物統計家の重要性と大阪市立大学大学院医学研究科修士コースにおける人材育成の取り組みと、大阪市立大学医学部附属病院臨床研究・イノベーション推進センターにおいて、本年より運用を開始した研究データ収集システムであるresearch electronic data capture(REDCap)について紹介する。(著者抄録)

  • 角膜疾患に対する未来医療 Reviewed

    西田 幸二, 前田 直之, 辻川 元一, 川崎 諭, 高 静花, 橋田 徳康, 相馬 剛至, 大家 義則, 馬場 耕一, 林 竜平, 藤本 久貴, 佐々本 弦, 原 進, 高柳 泰, 三田村 勇人, 浅尾 和伸, 渡辺 真矢, 木村 恵利香, 安藤 覚, 石川 幸, 香取 良祐, 野村 直樹, 荒木 さおり, 市川 達也, 不二門 尚, 瓶井 資弘, 松下 賢治, 坂口 裕和, 佐藤 茂, 森本 壮, 臼井 審一, 三木 篤也, 西田 健太郎, 佐柳 香織, 佐藤 達彦, 福嶋 葉子, 大浦 嘉仁, 原 千佳子, 若林 卓, 永原 裕紀子, 白木 暢彦, 松原 聖子, 岡野 光夫, 大和 雅之, 山中 伸弥, 澤 芳樹, 新谷 歩, 嶋澤 るみ子, 中谷 明弘, 今井 敦子, 横倉 俊二, 菊地 未来, 櫻井 美晴, 布施 昇, 中澤 徹, 榛村 重人, 坪田 一男, 畠 賢一郎, 井家 益和, 林 成晃, 小澤 洋介, 林 研一

    (公財)日本眼科学会 日本眼科学会雑誌   120 ( 3 )   226 - 244   2016.03( ISSN:0029-0203

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    直面する少子高齢化社会において,視機能を保存・回復させる次世代の眼科治療が医学的・社会的に希求されている.このような未来の眼科治療のパラダイムとして,2つの分野が核となると考える.一つは,円錐角膜や緑内障,黄斑変性などの慢性疾患に対する潜在時期/発症早期に対するprecision medicineをベースにした予測医療・早期介入治療である.もう一つはregenerative therapy(再生治療法)であり,これには細胞治療,再生医療,人工角膜,人工網膜などが含まれる.Precision medicineとは,ゲノム情報や環境要因が疾病発症/進行にどのように影響するか調べ,各々の疾病について患者をサブグループに分け,そのグループごとに適切な発症予防法や治療法を開発するという概念である.円錐角膜やドライアイなど角膜疾患に対してもprecision medicineの実践が有用と考えられるが,そのためには,ゲノム,画像,バイオマーカーなどの総括的な研究を実施し,疾患の発症や進行に関わるマーカーを探索することが必須である.本稿では,円錐角膜を対象に,疾患の発症や進行予測を目指して取り組んできたバイオマーカー,遺伝子マーカーの2つの探索研究の結果を紹介する.再生医療の開発には,幹細胞とそれを維持する微小環境(ニッチ)に関する基礎研究が必須である.我々は,N-カドヘリンという細胞接着分子が角膜上皮幹細胞ニッチに重要であることを世界に先駆けて提案してきた.また,p75陽性の角膜内皮細胞が角膜内皮前駆細胞の候補であることを初めて報告した.また,このような基礎研究の成果を活かして,角膜上皮と角膜内皮の再生治療法の開発を推進してきた.角膜上皮の再生治療法については,角膜上皮幹細胞疲弊症に対する自家口腔粘膜上皮細胞シートを世界で初めて開発し,first-in human臨床研究,多施設臨床研究を経て,医師主導治験を開始した.また,さらにより良い視力回復が得られる方法を目指し,iPS細胞を用いた自家角膜上皮再生医療の開発を進めてきた.一方,角膜内皮については,iPS細胞由来他家角膜内皮細胞を使用する再生治療法の開発を進めている.未来医療の実現は一筋縄ではいかない.真に患者に役に立つイノベーションは,世代を超えてはじめて生まれてくる.科学というバトンを次世代へつないでいきたい.(著者抄録)

  • 角膜疾患に対する未来医療

    西田 幸二, 前田 直之, 辻川 元一, 川崎 諭, 高 静花, 橋田 徳康, 相馬 剛至, 大家 義則, 馬場 耕一, 林 竜平, 藤本 久貴, 佐々本 弦, 原 進, 高柳 泰, 三田村 勇人, 浅尾 和伸, 渡辺 真矢, 木村 恵利香, 安藤 覚, 石川 幸, 香取 良祐, 野村 直樹, 荒木 さおり, 市川 達也, 不二門 尚, 瓶井 資弘, 松下 賢治, 坂口 裕和, 佐藤 茂, 森本 壮, 臼井 審一, 三木 篤也, 西田 健太郎, 佐柳 香織, 佐藤 達彦, 福嶋 葉子, 大浦 嘉仁, 原 千佳子, 若林 卓, 永原 裕紀子, 白木 暢彦, 松原 聖子, 岡野 光夫, 大和 雅之, 山中 伸弥, 澤 芳樹, 新谷 歩, 嶋澤 るみ子, 中谷 明弘, 今井 敦子, 横倉 俊二, 菊地 未来, 櫻井 美晴, 布施 昇, 中澤 徹, 榛村 重人, 坪田 一男, 畠 賢一郎, 井家 益和, 林 成晃, 小澤 洋介, 林 研一

    日本眼科学会雑誌   120 ( 3 )   226 - 244   2016.03( ISSN:0029-0203

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    直面する少子高齢化社会において,視機能を保存・回復させる次世代の眼科治療が医学的・社会的に希求されている.このような未来の眼科治療のパラダイムとして,2つの分野が核となると考える.一つは,円錐角膜や緑内障,黄斑変性などの慢性疾患に対する潜在時期/発症早期に対するprecision medicineをベースにした予測医療・早期介入治療である.もう一つはregenerative therapy(再生治療法)であり,これには細胞治療,再生医療,人工角膜,人工網膜などが含まれる.Precision medicineとは,ゲノム情報や環境要因が疾病発症/進行にどのように影響するか調べ,各々の疾病について患者をサブグループに分け,そのグループごとに適切な発症予防法や治療法を開発するという概念である.円錐角膜やドライアイなど角膜疾患に対してもprecision medicineの実践が有用と考えられるが,そのためには,ゲノム,画像,バイオマーカーなどの総括的な研究を実施し,疾患の発症や進行に関わるマーカーを探索することが必須である.本稿では,円錐角膜を対象に,疾患の発症や進行予測を目指して取り組んできたバイオマーカー,遺伝子マーカーの2つの探索研究の結果を紹介する.再生医療の開発には,幹細胞とそれを維持する微小環境(ニッチ)に関する基礎研究が必須である.我々は,N-カドヘリンという細胞接着分子が角膜上皮幹細胞ニッチに重要であることを世界に先駆けて提案してきた.また,p75陽性の角膜内皮細胞が角膜内皮前駆細胞の候補であることを初めて報告した.また,このような基礎研究の成果を活かして,角膜上皮と角膜内皮の再生治療法の開発を推進してきた.角膜上皮の再生治療法については,角膜上皮幹細胞疲弊症に対する自家口腔粘膜上皮細胞シートを世界で初めて開発し,first-in human臨床研究,多施設臨床研究を経て,医師主導治験を開始した.また,さらにより良い視力回復が得られる方法を目指し,iPS細胞を用いた自家角膜上皮再生医療の開発を進めてきた.一方,角膜内皮については,iPS細胞由来他家角膜内皮細胞を使用する再生治療法の開発を進めている.未来医療の実現は一筋縄ではいかない.真に患者に役に立つイノベーションは,世代を超えてはじめて生まれてくる.科学というバトンを次世代へつないでいきたい.(著者抄録)

  • 角膜疾患に対する未来医療 Reviewed

    西田 幸二, 前田 直之, 辻川 元一, 川崎 諭, 高 静花, 橋田 徳康, 相馬 剛至, 大家 義則, 馬場 耕一, 林 竜平, 藤本 久貴, 佐々本 弦, 原 進, 高柳 泰, 三田村 勇人, 浅尾 和伸, 渡辺 真矢, 木村 恵利香, 安藤 覚, 石川 幸, 香取 良祐, 野村 直樹, 荒木 さおり, 市川 達也, 不二門 尚, 瓶井 資弘, 松下 賢治, 坂口 裕和, 佐藤 茂, 森本 壮, 臼井 審一, 三木 篤也, 西田 健太郎, 佐柳 香織, 佐藤 達彦, 福嶋 葉子, 大浦 嘉仁, 原 千佳子, 若林 卓, 永原 裕紀子, 白木 暢彦, 松原 聖子, 岡野 光夫, 大和 雅之, 山中 伸弥, 澤 芳樹, 新谷 歩, 嶋澤 るみ子, 中谷 明弘, 今井 敦子, 横倉 俊二, 菊地 未来, 櫻井 美晴, 布施 昇, 中澤 徹, 榛村 重人, 坪田 一男, 畠 賢一郎, 井家 益和, 林 成晃, 小澤 洋介, 林 研一

    (公財)日本眼科学会 日本眼科学会雑誌   120 ( 3 )   226 - 244   2016.03( ISSN:0029-0203

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    直面する少子高齢化社会において,視機能を保存・回復させる次世代の眼科治療が医学的・社会的に希求されている.このような未来の眼科治療のパラダイムとして,2つの分野が核となると考える.一つは,円錐角膜や緑内障,黄斑変性などの慢性疾患に対する潜在時期/発症早期に対するprecision medicineをベースにした予測医療・早期介入治療である.もう一つはregenerative therapy(再生治療法)であり,これには細胞治療,再生医療,人工角膜,人工網膜などが含まれる.Precision medicineとは,ゲノム情報や環境要因が疾病発症/進行にどのように影響するか調べ,各々の疾病について患者をサブグループに分け,そのグループごとに適切な発症予防法や治療法を開発するという概念である.円錐角膜やドライアイなど角膜疾患に対してもprecision medicineの実践が有用と考えられるが,そのためには,ゲノム,画像,バイオマーカーなどの総括的な研究を実施し,疾患の発症や進行に関わるマーカーを探索することが必須である.本稿では,円錐角膜を対象に,疾患の発症や進行予測を目指して取り組んできたバイオマーカー,遺伝子マーカーの2つの探索研究の結果を紹介する.再生医療の開発には,幹細胞とそれを維持する微小環境(ニッチ)に関する基礎研究が必須である.我々は,N-カドヘリンという細胞接着分子が角膜上皮幹細胞ニッチに重要であることを世界に先駆けて提案してきた.また,p75陽性の角膜内皮細胞が角膜内皮前駆細胞の候補であることを初めて報告した.また,このような基礎研究の成果を活かして,角膜上皮と角膜内皮の再生治療法の開発を推進してきた.角膜上皮の再生治療法については,角膜上皮幹細胞疲弊症に対する自家口腔粘膜上皮細胞シートを世界で初めて開発し,first-in human臨床研究,多施設臨床研究を経て,医師主導治験を開始した.また,さらにより良い視力回復が得られる方法を目指し,iPS細胞を用いた自家角膜上皮再生医療の開発を進めてきた.一方,角膜内皮については,iPS細胞由来他家角膜内皮細胞を使用する再生治療法の開発を進めている.未来医療の実現は一筋縄ではいかない.真に患者に役に立つイノベーションは,世代を超えてはじめて生まれてくる.科学というバトンを次世代へつないでいきたい.(著者抄録)

  • 歯科研究における統計の手引き パートII(Primer of statistics in dental research: Part II) Reviewed

    Shintani Ayumi

    (公社)日本補綴歯科学会 Journal of Prosthodontic Research   58 ( 2 )   85 - 91   2014.04( ISSN:1883-1958

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  • 歯科研究における統計の手引き パートII(Primer of statistics in dental research: Part II) Reviewed

    Shintani Ayumi

    (公社)日本補綴歯科学会 Journal of Prosthodontic Research   58 ( 2 )   85 - 91   2014.04( ISSN:1883-1958

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  • ショック領域のトランスレーショナル・リサーチ 老化T細胞の再活性化に注目した高齢者岳血症治療戦略 基礎研究と米国型臨床研究教育プログラムによる新たなトランスレーショナルリサーチの展開 Reviewed

    井上 茂亮, 鈴木 恭子[宇都宮], 小森 由香子, 新谷 歩, Ely Wesley, 猪口 貞樹

    (一社)日本Shock学会 Shock: 日本Shock学会雑誌   28 ( 2 )   49 - 54   2014.02( ISSN:0919-8156

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    高齢者の敗血症は重症化しやすくその予後は極めて不良である。また高齢者のT細胞は活性化されにくく、高齢者敗血症患者ではT細胞の数と機能の低下が遷延している。このためわれわれは免疫疫賦活効果のある薬剤が高齢者敗血症の治療薬候補と考えており、とくにリンパ球の成長因子の1つであるインターロイキン-15に注目し基礎研究を展開し良好な結果が得られている。しかしながら本邦では治療に向けたさまざまな基礎研究が行われ良好な結果が得られているものの、その知見が臨床応用にいたることは少ない。その原因の1つとして、トランスレーショナルリサーチのためのシステムおよび臨床研究における教育プログラムが十分に整備されていないことがあげられる。本稿では、現在私が受講している米国Vanderbilt大学の臨床研究マスターコースの内容を紹介するとともに、本邦におけるトランスレーショナルリサーチの今後の展望について考察したい。(著者抄録)

  • 今日から使える統計学講座 歯学統計チェックリスト Reviewed

    新谷 歩

    (公社)日本補綴歯科学会 日本補綴歯科学会誌   6 ( 1 )   1 - 11   2014.01( ISSN:1883-4426

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    論文投稿からアクセプトまでのプロセスはEBM医療が盛んになる近年厳しさを増す一方です。医学雑誌の最高峰であるNew England Journal of Medicineでは、年間約5000本の論文が投稿され、最終関門の統計査読に到達した5%の論文の中から更に20%が統計手法の不備でリジェクトされます。査読者が何を見ているのかが事前に分かれば、過酷な査読地獄を生きぬくための強力な武器となるのではないでしょうか。British Dental Journalが提供している統計チェックリストを紹介しながら、歯学研究を行う際に留意したい10個のトピックについて解説します。(著者抄録)

  • 歯科学研究における統計学の入門書(Part I)(Primer of statistics in dental research(Part I)) Reviewed

    Shintani Ayumi

    (公社)日本補綴歯科学会 Journal of Prosthodontic Research   58 ( 1 )   11 - 16   2014.01( ISSN:1883-1958

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  • 今日から使える統計学講座 歯学統計チェックリスト Reviewed

    新谷 歩

    (公社)日本補綴歯科学会 日本補綴歯科学会誌   6 ( 1 )   1 - 11   2014.01( ISSN:1883-4426

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    論文投稿からアクセプトまでのプロセスはEBM医療が盛んになる近年厳しさを増す一方です。医学雑誌の最高峰であるNew England Journal of Medicineでは、年間約5000本の論文が投稿され、最終関門の統計査読に到達した5%の論文の中から更に20%が統計手法の不備でリジェクトされます。査読者が何を見ているのかが事前に分かれば、過酷な査読地獄を生きぬくための強力な武器となるのではないでしょうか。British Dental Journalが提供している統計チェックリストを紹介しながら、歯学研究を行う際に留意したい10個のトピックについて解説します。(著者抄録)

  • 歯科学研究における統計学の入門書(Part I)(Primer of statistics in dental research(Part I)) Reviewed

    Shintani Ayumi

    (公社)日本補綴歯科学会 Journal of Prosthodontic Research   58 ( 1 )   11 - 16   2014.01( ISSN:1883-1958

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  • 【治療や合併症のポイントがわかる!看護につながる!事例で学ぶ脳腫瘍】小児の脳腫瘍 Reviewed

    山崎 文之, 橋本 敦子, 福川 奈緒美, 武澤 友宏, 新谷 歩美, 和田 寿子, 井上 新菜, 松下 祐子, 千田 桃子, 田本 信江

    (株)メディカ出版 Brain Nursing   29 ( 9 )   907 - 911   2013.09( ISSN:0910-8459

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