Updated on 2024/04/11

写真a

 
NAKAMAE HIRIHISA
 
Organization
Graduate School of Medicine Department of Clinical Medical Science Associate Professor
School of Medicine Department of Medical Science
Title
Associate Professor
Affiliation
Institute of Medicine
Affiliation campus
Abeno Campus

Position

  • Graduate School of Medicine Department of Clinical Medical Science 

    Associate Professor  2022.04 - Now

  • School of Medicine Department of Medical Science 

    Associate Professor  2022.04 - Now

Degree

  • Medical doctor ( Osaka City University )

Research Areas

  • Life Science / Hematology and medical oncology  / allogeneic hematopoietic cell transplanation

  • Life Science / Hematology and medical oncology  / Ph-positive leukemia

  • Others / Others  / Laboratory medicine

Research Interests

  • hematopoietic cell transplantation

  • Ph-positive leukemia

  • HLA-haploidentical hematopoietic cell transplantation

  • HLA-mismatched hematpoietic cell transplantation

Research subject summary

  • HLA haplo-identical hematopoietic cell transplantation
    HLA mismathed hematopoietic cell transplantation
    Prediction and elucidation of mechanisms of complications after hematopoietic cell transplantation
    Immune reconstitution after hematopoietic cell transplantation
    Impact of minimal residual disease on outcomes after hematopietic cell transplantation
    Pathophysiology and treatment of Ph-positive leukemia

Professional Memberships

  • The Japanese Society of Internal Medicine

      Domestic

  • The Japanese Society of Hematology

      Domestic

  • Japanese Society for Transplantation and Cellular Therapy

      Domestic

  • 日本臨床検査医学会

      Domestic

  • 近畿血液学会

  • 日本補体学会

      Domestic

  • 日本輸血・細胞治療学会

      Domestic

  • Japan Society for Medical Eduacation

      Domestic

  • American Society for Blood and Marrow Transplantation: ASBMT

      Overseas

  • Asia Pacific Blood and Marrow Transplantation: APBMT

      Overseas

  • 日本腫瘍循環器学会

      Domestic

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Committee Memberships (off-campus)

  • 年次総会プログラム副委員長   日本造血・免疫細胞療法学会  

    2023 - Now 

  • メンバー   HLA不適合血縁者間移植ガイドライン作成部会  

    2020.07 - Now 

  • 賞等選考委員   日本造血・免疫細胞療法学会  

    2020.04 - Now 

  • 重篤副作用ガイドライン委員会 委員   日本血液学会  

    2018.09 - Now 

  • 年次集会プログラム委員   日本造血・免疫細胞療法学会  

    2018.02 - 2019.03 

  • 患者手帳作成委員   日本造血・免疫細胞療法学会  

    2015.05 - Now 

  • 評議員   日本造血・免疫細胞療法学会  

    2015.03 - Now 

  • 在り方委員   日本造血・免疫細胞療法学会  

    2014.03 - 2020.04 

  • 年次集会プログラム委員   日本造血・免疫細胞療法学会  

    2013.10 - 2015.03 

  • 学術集会企画委員   日本造血・免疫細胞療法学会  

    2013.08 - 2015.03 

  • 統計調査委員会 委員   日本血液学会  

    2012.09 - 2014.08 

  • 評議員    近畿血液学地方会  

    2010.11 - Now 

  • 臨床研究委員   日本造血・免疫細胞療法学会  

    2010.02 - 2014.03 

  • 評議員   日本血液学会  

    2009.09 - Now 

  • 近畿支部評議員   日本内科学会  

    2005.09 - Now 

▼display all

Job Career (off-campus)

  • Osaka Metropolitan University Graduate School of Medicine Department of Clinical Medical Science

    2022.04 - Now

  • Osaka Metropolitan University School of Medicine Department of Medical Science

    2022.04 - Now

  • Osaka City University   Graduate School of Medicine Clinical Medicine Course

    2011.04 - Now

  • Osaka City University   University Hospital

    2011.04 - Now

Papers

  • Autotaxin is a potential predictive marker for the development of veno-occlusive disease/sinusoidal obstruction syndrome after allogeneic hematopoietic cell transplantation.

    Takemura K, Nakamae M, Okamura H, Sakatoku K, Ido K, Makuuchi Y, Kuno M, Takakuwa T, Hirose A, Nishimoto M, Nakashima Y, Koh H, Igarashi K, Kubota H, Hino M, Nakamae H

    Annals of hematology   2024.03( ISSN:0939-5555

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    International / domestic magazine:International journal  

    DOI: 10.1007/s00277-024-05685-0

    PubMed

  • Pretransplant hepatomegaly is linked to relapse in patients with leukemia and myelodysplastic syndrome not in remission.

    Okayama Y, Harada N, Makuuchi Y, Kuno M, Takakuwa T, Okamura H, Hirose A, Nakamae M, Nishimoto M, Nakashima Y, Koh H, Hino M, Nakamae H

    International journal of hematology   119 ( 3 )   316 - 326   2024.03( ISSN:0925-5710

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    International / domestic magazine:International journal  

    DOI: 10.1007/s12185-023-03707-7

    PubMed

  • HLA-Haploidentical Peripheral Blood Stem Cell Transplantation with Post-Transplantation Cyclophosphamide versus HLA-Matched Unrelated Donor Transplantation for Myelodysplastic Syndrome.

    Yosuke Nakaya, Hideo Koh, Takaaki Konuma, Yoshimitsu Shimomura, Ken Ishiyama, Hidehiro Itonaga, Masayuki Hino, Noriko Doki, Tetsuya Nishida, Hiroyuki Ohigashi, Ken-Ichi Matsuoka, Yoshinobu Kanda, Yumiko Maruyama, Masashi Sawa, Tetsuya Eto, Nobuhiro Hiramoto, Takahiro Fukuda, Yoshiko Atsuta, Hirohisa Nakamae

    Transplantation and cellular therapy   30 ( 3 )   316.e1 - 316.e12   2024.03( ISSN:26666367

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    Authorship:Corresponding author   Publishing type:Research paper (scientific journal)   International / domestic magazine:International journal  

    Allogeneic hematopoietic cell transplantation (allo-HCT) is the sole curative therapy for myelodysplastic syndrome (MDS). In the absence of an HLA-matched sibling donor, an HLA-matched unrelated donor (MUD) is considered the leading candidate. However, in recent decades, the alternative donor pool has been extended to HLA-haploidentical donors, especially with the development of graft-versus-host disease (GVHD) prophylaxis using post-transplantation cyclophosphamide (PTCy). Comparative data for haploidentical and MUD allo-HCT in patients with MDS are scarce. We retrospectively analyzed 697 adult patients with MDS who underwent HLA-haploidentical peripheral blood stem cell transplantation (haplo-PBSCT) with PTCy (n = 136), MUD bone marrow transplantation (MUD-BMT) (n = 465), or MUD peripheral blood stem cell transplantation (MUD-PBSCT) (n = 96) as their first allo-HCT between 2014 and 2020 using Japanese registry data. Multivariable analyses demonstrated faster neutrophil engraftment (hazard ratio [HR], 2.19; 95% confidence interval [CI], 1.65 to 2.90; P < .001) and platelet engraftment (HR, 2.31; 95% CI, 1.72 to 3.10; P < 0001) in the MUD-PBSCT cohort compared with the haplo-PBSCT cohort. MUD-BMT was associated with a higher incidence of grade II-IV acute GVHD than haplo-PBSCT (HR, 1.52; 95% CI, 1.00 to 2.29; P = .048). Among patients without in vivo T cell depletion using antithymocyte globulin (ATG) (haplo-PBSCT, n = 136; MUD-BMT, n = 446; MUD-PBSCT, n = 65), MUD-PBSCT recipients experienced faster hematopoietic recovery, MUD-BMT recipients (HR, 1.54; 95% CI, 1.02 to 2.32; P = .042) or MUD-PBSCT recipients (HR, 1.83; 95% CI, 1.06 to 3.18; P = .03) had a higher incidence of grade II-IV acute GVHD, and MUD-PBSCT recipients developed chronic GVHD more frequently than haplo-PBSCT recipients (HR, 1.74; 95% CI, 1.04 to 2.89; P = .034). There were no significant differences in overall survival, disease-free survival, GVHD-free relapse-free survival, relapse, or nonrelapse mortality in the haplo-PBSCT cohort versus the MUD-BMT or MUD-PBSCT cohorts. In conclusion, despite differences in the incidences of hematopoietic engraftment and GVHD depending on graft type and ATG use in MUD transplant recipients, major transplantation outcomes were comparable between recipients of haplo-PBSCT using PTCy and recipients of MUD-BMT or MUD-PBSCT.

    DOI: 10.1016/j.jtct.2023.10.021

    PubMed

  • Effect of Conditioning Regimens and Graft-versus-Host Disease Prophylaxis on the Outcomes of Umbilical Cord Blood Transplantation Performed with Cyclophosphamide/Total Body Irradiation-Based Regimens.

    Nobuhiko Imahashi, Naoki Kurita, Takaaki Konuma, Satoshi Takahashi, Tetsuya Nishida, Masatsugu Tanaka, Hirohisa Nakamae, Toshiro Kawakita, Shuichi Ota, Noriko Doki, Yasushi Onishi, Masashi Sawa, Kazutaka Ozeki, Nobuhiro Hiramoto, Makoto Onizuka, Fumihiko Ishimaru, Tatsuo Ichinohe, Yoshiko Atsuta, Junya Kanda

    Transplantation and cellular therapy   30 ( 3 )   318.e1 - 318.e11   2024.03( ISSN:26666367

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    Publishing type:Research paper (scientific journal)   International / domestic magazine:International journal  

    Umbilical cord blood (UCB) is a valuable alternative donor source for allogeneic hematopoietic stem cell transplantation. Various conditioning regimens and graft-versus-host disease (GVHD) prophylaxis regimens aimed at improving the outcomes of umbilical cord blood transplantation (UCBT) have been explored; however, the differences in their effects remain unclear. This study was conducted to elucidate the differences in the effects of conditioning and GVHD prophylaxis regimens on UCBT outcomes by disease type in a nationwide, retrospective study. We retrospectively analyzed the effects of conditioning and GVHD prophylaxis regimens on the outcomes of UCBT performed with cyclophosphamide (Cy)/total body irradiation (TBI)-based regimens in patients with acute myeloid leukemia (AML; n = 1126), acute lymphoblastic leukemia (ALL; n = 620), myelodysplastic syndrome (MDS; n = 170), and lymphoma (n = 128). Multivariate analysis for overall survival (OS) demonstrated the benefit of adding high-dose cytarabine to the Cy/TBI regimen for the AML group (relative risk [RR], .76; P = .003) and lymphoma group (RR, .54; P = .02), but not for the ALL and MDS groups. In the ALL group, adding etoposide to the Cy/TBI regimen was associated with a lower OS (RR, 1.45; P = .03). For GVHD prophylaxis, a tacrolimus/methotrexate regimen was associated with a lower OS compared with a cyclosporine/methotrexate regimen in the AML group (RR, 1.26; P = .01); this difference was not observed in the other groups. These differences in OS according to the conditioning and GVHD prophylaxis regimen were attributable mainly to differences in relapse risk. Our data show that the effects of conditioning regimens and GVHD prophylaxis on UCBT outcomes differed according to disease type. UCBT outcomes could be improved by selecting optimal conditioning regimens and GVHD prophylaxis for each disease type.

    DOI: 10.1016/j.jtct.2023.12.004

    PubMed

  • First complete remission favours haploidentical haematopoietic stem cell transplantation with post‐transplant cyclophosphamide over cord blood transplantation in acute lymphoblastic leukaemia

    Tomoyasu Jo, Tomoaki Ueda, Yu Akahoshi, Tadakazu Kondo, Naoyuki Uchida, Masatsugu Tanaka, Hirohisa Nakamae, Noriko Doki, Shuichi Ota, Masashi Sawa, Hiroyuki Ohigashi, Yumiko Maruyama, Nobuyuki Takayama, Tetsuya Nishida, Nobuhiro Hiramoto, Yuta Katayama, Yoshinobu Kanda, Tatsuo Ichinohe, Yoshiko Atsuta, Yasuyuki Arai

    British Journal of Haematology   2024.02( ISSN:0007-1048

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    Publishing type:Research paper (scientific journal)   International / domestic magazine:International journal  

    Summary

    To assess the benefits of HLA‐haploidentical haematopoietic stem cell transplantation using post‐transplant cyclophosphamide (PTCy‐haplo) relative to those of umbilical cord blood (UCB) transplantation in acute lymphoblastic leukaemia (ALL), we analysed 1999 patients (PTCy‐haplo, 330; UCB, 1669), using the nationwide Japanese registry. PTCy‐haplo was associated with a significantly higher relapse rate, but lower non‐relapse mortality, which results in overall survival and disease‐free survival, comparable to those of UCB. Among patients in CR1, PTCy‐haplo showed a significantly higher survival than UCB regardless of the CD34<sup>+</sup> cell dose. Our findings provide valuable insights into the donor selection algorithm in allogeneic HSCT for adult patients with ALL.

    DOI: 10.1111/bjh.19372

    PubMed

  • RhD mismatch does not affect haematopoietic recovery, graft-versus-host disease and survival in allogeneic haematopoietic cell transplantation: A Japanese registry-based study.

    Konuma T, Uchida N, Takeda W, Doki N, Yoshihara S, Nishida T, Kuriyama T, Tanaka M, Ohigashi H, Nakamae H, Katayama Y, Ota S, Hashii Y, Ishimaru F, Fukuda T, Ohbiki M, Atsuta Y

    Vox sanguinis   2024.02( ISSN:0042-9007

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    International / domestic magazine:International journal  

    DOI: 10.1111/vox.13610

    PubMed

  • Prognostic factors in haploidentical transplantation with post-transplant cyclophosphamide for acute myeloid leukemia.

    Shibata S, Arai Y, Kondo T, Mizuno S, Yamasaki S, Akasaka T, Doki N, Ota S, Maruyama Y, Matsuoka KI, Nagafuji K, Eto T, Tanaka T, Ohigashi H, Nakamae H, Onizuka M, Fukuda T, Atsuta Y, Yanada M

    Cytotherapy   2024.02( ISSN:1465-3249

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    International / domestic magazine:International journal  

    DOI: 10.1016/j.jcyt.2024.02.010

    PubMed

  • Comparison of haploidentical transplantation and single cord blood transplantation for myelofibrosis.

    Sakatoku K, Murata M, Shimazu Y, Uchida N, Yoshihara S, Uehara Y, Takahashi S, Kobayashi H, Tanaka H, Nakano N, Ishimaru F, Ichinohe T, Atsuta Y, Nagamura-Inoue T, Nakamae H

    Bone marrow transplantation   2024.02( ISSN:0268-3369

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    Authorship:Last author   International / domestic magazine:International journal  

    DOI: 10.1038/s41409-024-02244-z

    PubMed

  • A comparison of long-term outcomes by donor type in the era of post-transplantation cyclophosphamide for aggressive adult T-cell leukemia/lymphoma.

    Hirose A, Koh H, Nakamae M, Nakashima Y, Nishimoto M, Okamura H, Makuuchi Y, Kuno M, Takakuwa T, Ido K, Sakatoku K, Hino M, Nakamae H

    Bone marrow transplantation   2024.02( ISSN:0268-3369

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    International / domestic magazine:International journal  

    DOI: 10.1038/s41409-024-02231-4

    PubMed

  • Peripheral blood stem cell transplantation using HLA-haploidentical donor with post-transplant cyclophosphamide versus HLA-matched sibling donor for lymphoma.

    Nakaya Y, Nakamae H, Nishikubo M, Kondo E, Fukuda T, Hiramoto N, Mori Y, Nagafuji K, Eto T, Onishi Y, Uchida N, Ishikawa J, Matsuoka KI, Yui S, Takase K, Kawakita T, Kanda J, Ichinohe T, Atsuta Y, Kako S

    Bone marrow transplantation   2024.02( ISSN:0268-3369

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    Authorship:Corresponding author   International / domestic magazine:International journal  

    DOI: 10.1038/s41409-024-02229-y

    PubMed

  • Updated comparable efficacy of cord blood transplantation for chronic myelomonocytic leukaemia: a nationwide study.

    Kurosawa S, Shimomura Y, Ishiyama K, Fuse K, Shimazu Y, Doki N, Uchida N, Tanaka M, Takahashi S, Sakurai M, Kobayashi H, Katayama Y, Takada S, Ozeki K, Nakamae H, Ishimaru F, Kanda Y, Ichinohe T, Atsuta Y, Itonaga H

    Bone marrow transplantation   2024.02( ISSN:0268-3369

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    International / domestic magazine:International journal  

    DOI: 10.1038/s41409-024-02223-4

    PubMed

  • Development and evaluation of a rapid one-step high sensitivity real-time quantitative PCR system for minor BCR-ABL (e1a2) test in Philadelphia-positive acute lymphoblastic leukemia (Ph+ ALL).

    Hidaka M, Inokuchi K, Uoshima N, Takahashi N, Yoshida N, Ota S, Nakamae H, Iwasaki H, Watanabe K, Kosaka Y, Komatsu N, Meguro K, Najima Y, Eto T, Kondo T, Kimura S, Yoshida C, Ishikawa Y, Sawa M, Hata T, Horibe K, Iida H, Shimomura T, Dobashi N, Sugiura I, Makiyama J, Miyagawa N, Sato A, Ito R, Matsumura I, Kanakura Y, Naoe T

    Japanese journal of clinical oncology   54 ( 2 )   153 - 159   2024.02( ISSN:0368-2811

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    International / domestic magazine:International journal  

    DOI: 10.1093/jjco/hyad156

    PubMed

  • HLA haploidentical stem cell transplantation from HLA homozygous donors to HLA heterozygous donors may have lower survival rates than haploidentical transplantation from HLA heterozygous donors to HLA heterozygous donors: a retrospective nationwide analysis.

    Fukunaga K, Ikegame K, Nakamae H, Doki N, Fukuda T, Kondo Y, Ara T, Eto T, Mori Y, Matsuoka KI, Kanda Y, Onizuka M, Atsuta Y, Ichinohe T, Morishima S, Kanda J, JSTCT HLA Working Group

    International journal of hematology   119 ( 2 )   173 - 182   2024.02( ISSN:0925-5710

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    International / domestic magazine:International journal  

    DOI: 10.1007/s12185-023-03693-w

    PubMed

  • Hematopoietic stem cell transplantation from haploidentical offspring donors using post-transplant cyclophosphamide versus human leukocyte antigen-matched siblings in older patients with myelodysplastic syndrome.

    Yoshimitsu Shimomura, Tetsuhisa Kitamura, Takaaki Konuma, Yosuke Nakaya, Noriko Doki, Masashi Sawa, Hirohisa Nakamae, Tetsuya Eto, Tetsuya Nishida, Hiroyuki Ohigashi, Shuichi Ota, Makoto Onizuka, Nobuhiro Hiramoto, Toshiro Kawakita, Junya Kanda, Tatsuo Ichinohe, Yoshiko Atsuta, Hidehiro Itonaga

    American journal of hematology   99 ( 2 )   E42 - E45   2024.02( ISSN:0361-8609

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    International / domestic magazine:International journal  

    DOI: 10.1002/ajh.27160

    PubMed

  • Comparison of long-term outcomes after first HLA-mismatched unrelated donor transplantation with single unrelated cord blood transplantation using reduced-intensity or reduced-toxicity conditioning.

    Kuno M, Koh H, Ido K, Sakatoku K, Makuuchi Y, Takakuwa T, Hirose A, Okamura H, Nishimoto M, Nakashima Y, Nakamae M, Hino M, Nakamae H

    Transplant immunology   82   101988   2024.02( ISSN:0966-3274

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    International / domestic magazine:International journal  

    DOI: 10.1016/j.trim.2024.101988

    PubMed

  • Effect of graft-versus-host disease on outcomes of HLA-haploidentical peripheral blood transplantation using post-transplant cyclophophamide.

    Yoshimitsu Shimomura, Sho Komukai, Tetsuhisa Kitamura, Tomotaka Sobue, Yu Akahoshi, Junya Kanda, Hiroyuki Ohigashi, Hirohisa Nakamae, Nobuhiro Hiramoto, Koji Nagafuji, Takashi Tanaka, Tetsuya Eto, Shuichi Ota, Yumiko Maruyama, Takashi Akasaka, Ken-Ichi Matsuoka, Yasuo Mori, Takahiro Fukuda, Yoshiko Atsuta, Seitaro Terakura

    Bone marrow transplantation   59 ( 1 )   66 - 75   2024.01( ISSN:0268-3369

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    Publishing type:Research paper (scientific journal)   International / domestic magazine:International journal  

    There is limited evidence regarding the association between graft-versus-host disease (GVHD) and reduced relapse in patients who undergo allogeneic hematopoietic stem cell transplantation from haploidentical donors (haplo-HSCT) using post-transplant cyclophosphamide (PTCY). We investigated the association between GVHD and transplant outcomes in 938 patients who received haplo-HSCT using PTCY. Overall survival (OS), relapse rate, and non-relapse mortality (NRM) were evaluated using landmark analysis at the landmark points at 100 and 360 days after HSCT for acute and chronic GVHD, respectively. Grade I-II acute GVHD was not associated with OS (adjusted hazard ratio: 1.15, 95% confidence interval: 0.85-1.57), relapse (1.03, 0.74-1.45) and NRM (1.15, 0.74-1.77). Conversely, grade III-IV acute GVHD was associated with higher NRM (3.16, 1.61-6.19), but no other outcomes. Limited chronic GVHD was not associated with OS (1.11, 0.48-1.95), relapse (1.05, 0.30-3.75) and NRM (1.30, 0.45-3.79). Extensive chronic GVHD was associated with higher NRM (2.40, 1.03-5.57), but no other outcome. In conclusion, any GVHD was not associated with a reduced relapse rate and improved OS, and Grade III-IV acute GVHD and extensive chronic GVHD were associated with higher NRM in patients who received haplo-HSCT using PTCY.

    DOI: 10.1038/s41409-023-02142-w

    PubMed

  • Single-unit unrelated cord blood transplantation versus HLA-matched sibling transplantation in adults with advanced myelodysplastic syndrome: A registry-based study from the adult MDS working group of the Japanese society for transplantation and cellular therapy.

    Takaaki Konuma, Hidehiro Itonaga, Yoshimitsu Shimomura, Machiko Fujioka, Kazunari Aoki, Naoyuki Uchida, Makoto Onizuka, Atsushi Jinguji, Masatsugu Tanaka, Yasunori Ueda, Yuta Katayama, Masashi Sawa, Haruyuki Tanaka, Hirohisa Nakamae, Toshiro Kawakita, Yumiko Maruyama, Satoshi Takahashi, Fumihiko Ishimaru, Junya Kanda, Tatsuo Ichinohe, Yoshiko Atsuta

    Hematological oncology   42 ( 1 )   e3217   2024.01( ISSN:0278-0232

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    Publishing type:Research paper (scientific journal)   International / domestic magazine:International journal  

    Allogeneic hematopoietic stem cell transplantation (HCT) remains the only potential curative therapeutic modality for advanced myelodysplastic syndrome (MDS). Within HCT, the advancement of cord blood transplantation (CBT) procedures has resulted in a drastic expansion of CBT as a donor source for MDS. However, data comparing matched sibling donors (MSDs) HCT with CBT for advanced MDS, which was defined as refractory anemia with an excess of blasts (RAEB)-1 and RAEB-2 according to the World Health Organization classification at the time of HCT, have not been explored. We retrospectively compared survival and other posttransplant outcomes in 999 adult patients with advanced MDS after receiving allogeneic HCT in Japan between 2011 and 2020, using either MSD (n = 331) or single-unit unrelated cord blood (UCB) (n = 668). In the multivariate analysis, there were no significant differences in overall survival (hazard ratio [HR], 1.10; 95% confidence interval [CI], 0.90-1.34; P = 0.347), disease-free survival (HR, 1.01; 95% CI, 0.84-1.23; P = 0.845), relapse (HR, 0.88; 95% CI, 0.68-1.15; P = 0.370), or non-relapse mortality (HR, 1.15; 95% CI, 0.87-1.50; P = 0.310) between MSD recipients and UCB recipients. UCB was significantly associated with lower neutrophil (HR, 0.28; 95% CI, 0.24-0.33; P < 0.001) and lower platelet (HR, 0.29; 95% CI, 0.23-0.36; P < 0.001) recovery compared to MSD. UCB was significantly associated with a lower incidence of chronic graft-versus-host disease (GVHD) (HR, 0.57; 95% CI, 0.44-0.75; P < 0.001) and extensive chronic GVHD (HR, 0.46; 95% CI, 0.32-0.67; P < 0.001) compared to MSD. Similar results were observed after adjusting for differences between MSD and UCB recipients by propensity score matching analysis. Our study demonstrated that single CBT and MSD HCT had similar survival outcomes for adult patients with advanced MDS despite the lower hematopoietic recovery in CBT recipients and higher chronic GVHD in MSD recipients.

    DOI: 10.1002/hon.3217

    PubMed

  • Outcomes of allogeneic hematopoietic cell transplantation under letermovir prophylaxis for cytomegalovirus infection.

    Takenaka K, Fuji S, Matsukawa T, Uchida N, Kobayashi T, Tanaka M, Ara T, Ikegame K, Ozawa Y, Kanda Y, Sawa M, Maruyama Y, Fukuda T, Nakamae H, Kimura T, Ogata M, Seo S, Atsuta Y, Matsuo K, Nakasone H

    Annals of hematology   103 ( 1 )   285 - 296   2024.01( ISSN:0939-5555

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    International / domestic magazine:International journal  

    DOI: 10.1007/s00277-023-05474-1

    PubMed

  • Effectiveness of venetoclax and azacytidine against myeloid/natural killer cell precursor acute leukemia.

    Shiomi I, Nakako S, Nakane T, Ogawa Y, Araki T, Fujitani Y, Yamamura R, Hino M, Nakamae H

    International journal of hematology   119 ( 1 )   88 - 92   2024.01( ISSN:0925-5710

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    International / domestic magazine:International journal  

    DOI: 10.1007/s12185-023-03678-9

    PubMed

  • Invasive fungal infection caused by Blastobotrys mokoenaii in an immunocompromised patient with acute myeloid leukemia: A case report.

    Shiomi I, Makuuchi Y, Noura I, Kakuno S, Niki M, Kaimi Y, Ido K, Sakatoku K, Kuno M, Takakuwa T, Okamura H, Nishimoto M, Nakashima Y, Nakamae M, Kakeya H, Kohashi K, Hino M, Nakamae H

    Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy   2023.12( ISSN:1341-321X

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    International / domestic magazine:International journal  

    DOI: 10.1016/j.jiac.2023.12.002

    PubMed

  • Third HLA-haploidentical stem cell transplantation using post-transplant cyclophosphamide for relapsed acute leukemia.

    Harada N, Okamura H, Makuuchi Y, Kuno M, Takakuwa T, Nakamae M, Nishimoto M, Nakashima Y, Koh H, Hino M, Nakamae H

    Bone marrow transplantation   58 ( 12 )   1403 - 1405   2023.12( ISSN:0268-3369

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    Authorship:Last author   International / domestic magazine:International journal  

    DOI: 10.1038/s41409-023-02108-y

    PubMed

  • Comparison of haploidentical stem cell transplantation with post-transplant cyclophosphamide versus umbilical cord blood transplantation in adult patients with aplastic anemia.

    Yasushi Onishi, Takehiko Mori, Hirohito Yamazaki, Nobuhiro Hiramoto, Yoshitaka Zaimoku, Minoru Kanaya, Kosei Matsue, Makoto Onizuka, Nobuyuki Aotsuka, Naoyuki Uchida, Koichi Onodera, Junya Kanda, Hirohisa Nakamae, Ryusuke Yamamoto, Takuro Kuriyama, Takafumi Kimura, Tatsuo Ichinohe, Yoshiko Atsuta

    Transplantation and cellular therapy   29 ( 12 )   766.e1 - 766.e8   2023.12( ISSN:26666367

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    Publishing type:Research paper (scientific journal)   International / domestic magazine:International journal  

    BACKGROUND: Aplastic anemia patients who are refractory to immunosuppressive therapy or with very low neutrophil counts require allogeneic hematopoietic stem cell transplantation (HSCT). Umbilical cord blood transplantation (UCBT) has been a treatment option when an HLA-matched donor is not available, and HSCT from a related haploidentical donor using post-transplant cyclophosphamide (PTCY) for GVHD prophylaxis (PTCY-haplo) recently became another important approach. OBJECTIVE: We aimed to compare the outcomes of PTCY-haplo and UCBT in adult patients with aplastic anemia in order to identify more effective and safer approaches for alternative donor transplantation. STUDY DESIGN: Data in a nationwide registry were retrospectively analyzed to assess the outcomes of aplastic anemia patients aged ≥16 years who received PTCY-haplo or UCBT as first HSCT between 2016 and 2020. The primary endpoint was 1-year overall survival (OS) after HSCT. Secondary endpoints included 1-year failure-free survival (FFS), neutrophil and platelet engraftment, and acute and chronic GVHD. RESULTS: Eighty-three patients who received PTCY-haplo (n = 24) and UCBT (n = 59) were eligible. One-year OS rates were 78.5% (95%CI, 55.7 - 90.5) in the PTCY-haplo group and 77.5% (95%CI, 64.5 - 86.3, P=0.895) in the UCBT group. One-year FFS rates were 78.7% (95%CI, 56.1 - 90.6) in the PTCY-haplo group and 62.2% (95%CI, 48.5 - 73.3, P=0.212) in the UCBT group. Among patients <40 years, the PTCY-haplo group had a significantly higher FFS rate; 92.9% (95%CI, 59.1 - 99.0) vs. 63.9% (95%CI, 43.2 - 78.7, P=0.047). Neutrophil and platelet engraftment rates were significantly higher in the PTCY-haplo group than in the UCBT group; 95.8% (95%CI, 73.9 - 99.4) vs. 78.0% (95%CI, 65.1 - 86.6, P<0.001) and 83.3% (95%CI, 61.5 - 93.4) vs. 72.9% (95%CI, 59.6 - 82.4, P=0.025). No significant difference was observed in the cumulative incidence of grade II-IV acute GVHD and chronic GVHD between the two groups. CONCLUSIONS: Aplastic anemia patients achieved significantly higher neutrophil and platelet engraftment rates with PTCY-haplo than with UCBT. OS and the incidence of acute and chronic GVHD were similar between the two groups. In patients <40 years, the FFS rate was higher in the PTCY-haplo group. Therefore, PTCY-haplo is promising for alternative donor transplantation in adult patients with aplastic anemia.

    DOI: 10.1016/j.jtct.2023.09.009

    PubMed

  • Impact of MRD on clinical outcomes of unrelated hematopoietic stem cell transplantation in patients with Ph+ALL: A retrospective nationwide study Reviewed

    Shigeki Hirabayashi, Tadakazu Kondo, Satoshi Nishiwaki, Shuichi Mizuta, Noriko Doki, Takahiro Fukuda, Naoyuki Uchida, Yukiyasu Ozawa, Yoshinobu Kanda, Ryota Imanaka, Satoshi Takahashi, Jun Ishikawa, Shingo Yano, Hirohisa Nakamae, Tetsuya Eto, Takafumi Kimura, Junji Tanaka, Tatsuo Ichinohe, Yoshiko Atsuta, Shinichi Kako

    American Journal of Hematology   98 ( 10 )   1606 - 1618   2023.10( ISSN:0361-8609

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    DOI: 10.1002/ajh.27041

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  • Ibrutinib Induces a Dramatic Improvement for Idiopathic Refractory Ascites Following Allogeneic Hematopoietic Cell Transplantation

    Tazoe Kumiyo, Nishimoto Mitsutaka, Yamamoto Akira, Makuuchi Yosuke, Kuno Masatomo, Okamura Hiroshi, Nakashima Yasuhiro, Tanaka Sayaka, Ohsawa Masahiko, Hino Masayuki, Nakamae Hirohisa

    Internal Medicine   62 ( 18 )   2737 - 2741   2023.09( ISSN:0918-2918

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    <p>We herein report a case of idiopathic refractory ascites following allogeneic hematopoietic cell transplantation that was successfully treated with ibrutinib. A 39-year-old man presented with massive transudative ascites. Despite a high portal venous pressure, the liver histology showed traces of alloreactivity inconsistent with veno-occlusive disease/sinusoidal obstructive syndrome. Ibrutinib was administered for ascites possibly secondary to portal hypertension associated with the alloreactivity. The ascites dramatically improved, and the portal venous pressure was reduced. This case may help clarify the mechanism through which refractory ascites develops after allogeneic hematopoietic cell transplantation and establish appropriate treatment protocols. </p>

    DOI: 10.2169/internalmedicine.1139-22

    PubMed

  • Antibody-mediated pathogenesis of chronic GVHD through DBY/HLA class II complexes and induction of a GVL effect.

    Umino K, Morita K, Ikeda T, Kawaguchi SI, Nagayama T, Ito S, Minakata D, Ashizawa M, Yamamoto C, Hatano K, Sato K, Ohmine K, Fujiwara SI, Kimura SI, Kako S, Doki N, Ozawa Y, Mori Y, Eto T, Hiramoto N, Nakamae H, Kanda J, Ichinohe T, Atsuta Y, Nakasone H, Morishima S, Kanda Y

    Blood   142 ( 11 )   1008 - 1021   2023.09( ISSN:0006-4971

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    International / domestic magazine:International journal  

    DOI: 10.1182/blood.2023019799

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  • Risk factors and outcome of Stenotrophomonas maltophilia infection after allogeneic hematopoietic stem cell transplantation: JSTCT, Transplant Complications Working Group.

    Saburi M, Oshima K, Takano K, Inoue Y, Harada K, Uchida N, Fukuda T, Doki N, Ikegame K, Matsuo Y, Katayama Y, Ozawa Y, Matsuoka KI, Kawakita T, Mori Y, Ara T, Nakamae H, Kimura T, Kanda Y, Atsuta Y, Ogata M, Transplant Complications Working Group of the Japanese Society for Transplantation and Cellular Therapy

    Annals of hematology   102 ( 9 )   2507 - 2516   2023.09( ISSN:0939-5555

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    International / domestic magazine:International journal  

    DOI: 10.1007/s00277-023-05320-4

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  • Sinusoidal obstruction syndrome associated with disseminated toxoplasmosis involving the liver after allogeneic hematopoietic stem cell transplantation: A case report.

    Yosuke Makuuchi, Sayaka Tanaka, Hideo Koh, Makoto Niki, Kazumi Norose, Yosuke Nakaya, Kentaro Ido, Kazuki Sakatoku, Masatomo Kuno, Naonori Harada, Teruhito Takakuwa, Asao Hirose, Hiroshi Okamura, Mitsutaka Nishimoto, Yasuhiro Nakashima, Mika Nakamae, Kenji Hikosaka, Hiroshi Kakeya, Masahiko Ohsawa, Masayuki Hino, Hirohisa Nakamae

    Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy   29 ( 9 )   909 - 912   2023.09( ISSN:1341-321X

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    Sinusoidal obstruction syndrome (SOS) is a fatal complication after hematopoietic stem cell transplantation (HSCT). Only a few complications after HSCT have been reported as risk factors for SOS, including sepsis. Here, we report the case of a 35-year-old male diagnosed with Philadelphia chromosome-positive acute lymphoblastic leukemia who underwent peripheral blood HSCT from a human leukocyte antigen-matched unrelated female donor in remission. Graft-versus-host disease prophylaxis contained tacrolimus, methotrexate, and low-dose anti-thymoglobulin. The patient was treated with methylprednisolone for engraftment syndrome from day 22. On day 53, he presented worsening fatigue, breathlessness, and abdominal pain in the right upper quadrant that had persisted for 4 days. Laboratory tests showed severe inflammation, liver dysfunction, and positive for Toxoplasma gondii PCR. He died on day 55. An autopsy showed SOS and disseminated toxoplasmosis. Hepatic infection with T. gondii was identified in zone 3 of the liver, which overlapped with the pathological features of SOS. In addition, the timing of the exacerbation of hepatic dysfunction coincided with the onset of systemic inflammatory symptoms and T. gondii reactivation. This rare case of toxoplasmosis is the first to suggest that hepatic infection with T. gondii is strongly associated with SOS after HSCT.

    DOI: 10.1016/j.jiac.2023.05.009

    PubMed

  • Allogeneic stem cell transplantation for children and adolescents/young adults with de novo blastic phase chronic myeloid leukemia in the tyrosine kinase inhibitor era.

    Ishida H, Shimada H, Tanizawa A, Shimazu Y, Tachibana T, Doki N, Ara T, Matsuo Y, Nara M, Toubai T, Ino K, Nakamae H, Kato K, Kato K, Sato A, Hino M, Matsumoto K, Atsuta Y, Yasui M, Nagamura-Inoue T

    American journal of hematology   98 ( 8 )   E200 - E203   2023.08( ISSN:0361-8609

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    International / domestic magazine:International journal  

    DOI: 10.1002/ajh.26959

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  • 同種造血幹細胞移植後の遅発性間質性肺炎にみられる臨床的特徴(Clinical characteristics of late-onset interstitial pneumonia after allogeneic hematopoietic stem cell transplantation)

    Fujii Nobuharu, Onizuka Makoto, Fukuda Takahiro, Ikegame Kazuhiro, Kawakita Toshiro, Nakamae Hirohisa, Kobayashi Takeshi, Kataoka Keisuke, Tanaka Masatsugu, Kondo Tadakazu, Kato Koji, Sato Atsushi, Ichinohe Tatsuo, Atsuta Yoshiko, Ogata Masao, Suzuki Ritsuro, Nakasone Hideki, JSTCT Transplant Complications Working Group

    International Journal of Hematology   118 ( 2 )   242 - 251   2023.08( ISSN:0925-5710

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    同種造血幹細胞移植(アロHSCT)施行後における遅発性間質性肺炎の発症例について全国規模の調査を行った。まず、移植登録一元管理プログラムのデータベースを利用し、2005~2010年にアロHSCTを受けた患者14643名を組み入れた。そのうち間質性肺炎(IP)と診断され、その病因が感染症などではなかった440名を適格症例とした。それらの症例の施設へ症例報告フォームを送付し、197名分の回答を得た。IP発症がアロHSCT後90日以降であった73名(男性54名、年齢5~63歳)を解析した。69名(94.5%)はステロイドの全身投与で加療された34名(46.6%)では改善が示されていた。IP発症時点で慢性移植片対宿主病が存在していたことは、症状の非改善と有意に関連していた(オッズ比0.35)。最直近の経過観察(中央値で1471日)時点で26名が生存していた。死亡例47名のうち32名(68%)はIPに起因する死亡であった。3年時点の全生存率は38.8%、非再発死亡率は51.8%であった。多変量解析の結果、全生存率の予測因子として、IP発症時点での併存疾患と、パフォーマンスステータス(PS)スコアが2~4であることが同定された。また非再発死亡リスクの増大と有意に関連していた因子は、早期介入を要したサイトメガロウイルス再活性化、IP発症時の併存疾患、PSスコア2~4であった。

  • Effect of graft cell dose on second transplantation from a haploidentical donor with post-transplantation cyclophosphamide for relapsed/refractory acute leukemia.

    Nakaya Y, Nakamae H, Harada N, Okamura H, Sakatoku K, Ido K, Makuuchi Y, Kuno M, Takakuwa T, Hirose A, Nakamae M, Nishimoto M, Nakashima Y, Koh H, Hino M

    Bone marrow transplantation   58 ( 8 )   947 - 949   2023.08( ISSN:0268-3369

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    Authorship:Corresponding author   International / domestic magazine:International journal  

    DOI: 10.1038/s41409-023-01986-6

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  • Clinical characteristics of late-onset interstitial pneumonia after allogeneic hematopoietic stem cell transplantation.

    Fujii N, Onizuka M, Fukuda T, Ikegame K, Kawakita T, Nakamae H, Kobayashi T, Kataoka K, Tanaka M, Kondo T, Kato K, Sato A, Ichinohe T, Atsuta Y, Ogata M, Suzuki R, Nakasone H, JSTCT Transplant Complications Working Group

    International journal of hematology   118 ( 2 )   242 - 251   2023.08( ISSN:0925-5710

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    DOI: 10.1007/s12185-023-03624-9

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  • Posttransplant cyclophosphamide contributes to the impairment of the graft-versus-leukemia effect and the amelioration of graft-versus-host disease with the suppression of alloreactive T cells in a murine stem cell transplant model.

    Makuuchi Y, Nakashima Y, Nishimoto M, Koh H, Hino M, Nakamae H

    Experimental hematology   123   56 - 65   2023.07( ISSN:0301-472X

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    Authorship:Last author   International / domestic magazine:International journal  

    DOI: 10.1016/j.exphem.2023.04.003

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  • CMV reactivation after allogeneic HCT is associated with a reduced risk of relapse in acute lymphoblastic leukemia.

    Yu Akahoshi, Hideki Nakasone, Katsuto Takenaka, Satoshi Yamasaki, Momoko Nakamura, Noriko Doki, Masatsugu Tanaka, Yukiyasu Ozawa, Naoyuki Uchida, Takahide Ara, Hirohisa Nakamae, Shuichi Ota, Makoto Onizuka, Shingo Yano, Junji Tanaka, Takahiro Fukuda, Yoshinobu Kanda, Yoshiko Atsuta, Shinichi Kako, Masamitsu Yanada, Yasuyuki Arai

    Blood advances   7 ( 12 )   2699 - 2708   2023.06( ISSN:2473-9529

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    Publishing type:Research paper (scientific journal)   International / domestic magazine:International journal  

    Cytomegalovirus reactivation (CMVR) after allogeneic hematopoietic cell transplantation (HCT) is a frequent complication related to survival outcomes, but the impact of CMVR on relapse is still unclear, especially in acute lymphoblastic leukemia (ALL). In this nationwide retrospective study, we included patients with acute myeloid leukemia (AML) and ALL in first or second complete remission who underwent their first HCT using pre-emptive strategy for CMVR. Because ninety percent of cases with CMVR had occurred by day 64 and ninety percent of cases with grades II to IV acute GVHD had occurred by day 58, a landmark point was set at day 65. In the landmark analyses, 3793 patients with AML and 2213 patients with ALL who survived without relapse for at least 65 days were analyzed. In the multivariate analyses, CMVR was associated with a lower incidence of relapse in both AML (hazard ratio [HR], 0.81; 95% confidence interval [CI], 0.69-0.95; P = 0.009) and ALL (HR, 0.81; 95% CI, 0.66-0.99; P = 0.045). These findings were confirmed when we treated CMVR as a time-dependent covariate. Moreover, our study suggested that the protective effect of CMVR on relapse was independent of acute GVHD. A post-hoc subgroup analysis that combined AML and ALL showed that CMVR had a mild anti-leukemia effect without effect modification in contrast to the impact of CMVR on NRM. Our findings may provide important implications for the strategy used for CMV prophylaxis after HCT.

    DOI: 10.1182/bloodadvances.2022009376

    PubMed

  • Effect of graft-versus-host disease on posttransplant outcomes following single cord blood transplantation in comparison to haploidentical transplantation with posttransplant cyclophosphamide for adult acute myeloid leukemia.

    Takaaki Konuma, Kensuke Matsuda, Yoshimitsu Shimomura, Susumu Tanoue, Junichi Sugita, Yoshihiro Inamoto, Masahiro Hirayama, Takahide Ara, Hirohisa Nakamae, Shuichi Ota, Yumiko Maruyama, Tetsuya Eto, Naoyuki Uchida, Masatsugu Tanaka, Kazuya Ishiwata, Satoshi Koi, Satoshi Takahashi, Yukiyasu Ozawa, Makoto Onizuka, Yoshinobu Kanda, Takafumi Kimura, Tatsuo Ichinohe, Yoshiko Atsuta, Junya Kanda, Masamitsu Yanada

    Transplantation and cellular therapy   29 ( 6 )   365.e1 - 365.e11   2023.06( ISSN:26666367

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    Publishing type:Research paper (scientific journal)   International / domestic magazine:International journal  

    BACKGROUND: The possibility that human leukocyte antigen (HLA) mismatches could reduce relapse after alternative HLA-mismatched allogeneic hematopoietic cell transplantation (HCT) is an attractive concept for acute myeloid leukemia (AML). However, it remains unclear whether the prognostic effect of graft-versus-host disease (GVHD) on survival differs between single-unit cord blood transplantation (CBT) or haploidentical HCT using posttransplant cyclophosphamide (PTCy-haplo HCT) for AML. OBJECTIVE: The objective of this retrospective study was to compare the effect of acute and chronic GVHD on posttransplant outcomes between CBT and PTCy-haplo HCT. STUDY DESIGN: We retrospectively evaluated the effect of acute and chronic GVHD on posttransplant outcomes following CBT and PTCy-haplo HCT in adults with AML (n=1,981) between 2014 and 2020 using a Japanese registry database. RESULTS: In the univariate analysis, the probability of overall survival was significantly greater in patients who developed grade I-II acute GVHD (P<0.001 by log-rank test) and limited chronic GVHD (P<0.001 by log-rank test) among CBT recipients, but these effects were not significant among PTCy-haplo HCT recipients. In the multivariate analysis, in which the development of GVHD was treated as a time-dependent covariate, the effect of grade I-II acute GVHD on reducing overall mortality was significant between CBT and PTCy-haplo HCT (adjusted hazard ratio [HR] for CBT: 0.73, 95% confidence interval [CI]: 0.60-0.87; adjusted HR for PTCy-haplo HCT: 1.07, 95% CI: 0.70-1.64; p for interaction=0.038). CONCLUSION: Our data demonstrate that grade I-II acute GVHD was associated with a significant improvement in overall mortality in adults with AML receiving CBT but not PTCy-haplo HCT.

    DOI: 10.1016/j.jtct.2023.03.001

    PubMed

  • Fulminant Metastatic Cellulitis Caused by Stenotrophomonas Maltophilia Infection and Subsequent Candida Parapsilosis Fungemia After Cord Blood Transplantation.

    Takagi I, Harada N, Niki M, Yamada K, Makuuchi Y, Kuno M, Takakuwa T, Okamura H, Nishimoto M, Nakashima Y, Koh H, Kakeya H, Hino M, Nakamae H

    Transplantation proceedings   55 ( 3 )   706 - 710   2023.04( ISSN:0041-1345

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    Authorship:Last author   International / domestic magazine:International journal  

    DOI: 10.1016/j.transproceed.2023.02.028

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  • Two cases of eosinophilic gastrointestinal disorder due to newly appearing food allergies after cord blood transplantation.

    Naonori Harada, Yosuke Makuuchi, Masatomo Kuno, Teruhito Takakuwa, Hiroshi Okamura, Mitsutaka Nishimoto, Yasuhiro Nakashima, Hideo Koh, Miho Sakaida, Sayaka Tanaka, Yuko Kuwae, Akira Higashimori, Fumino Tanaka, Masahiko Ohsawa, Yasuhiro Fujiwara, Masayuki Hino, Hirohisa Nakamae

    Transplant immunology   77   101781 - 101781   2023.04( ISSN:0966-3274

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    Eosinophilic gastrointestinal disorders (EGIDs) are infrequent complications after allogeneic hematopoietic cell transplantation (allo-HCT). Furthermore, it is well-known that allergic diseases are transferable after allo-HCT from allergic donors to non-allergic recipients. However, the type of graft-versus host disease (GVHD) prophylaxis that leads to allergic disease transfer is unclear. Furthermore, no study has reported a case of acquired food allergy resulting in EGID that was detected based on the clinical course and the detection of antigen-specific immunoglobulin E after allo-HCT. We encountered two patients with acute leukemia accompanied by eosinophilic esophagitis (EoE) and eosinophilic gastroenteritis (EGE) due to newly appearing food allergy after cord blood transplantation (CBT) with T-cell non-depletion GVHD prophylaxis. Despite having no history of allergic disease, the patients experienced allergic symptoms due to dairy products (Case 1) and eggs (Case 2) after CBT. They subsequently experienced severe nausea, heartburn, and anorexia (Case 1) and diarrhea (Case 2). Cases 1 and 2 were diagnosed with EoE and EGE, respectively, based on endoscopic and histological examinations. Dietary treatment without steroids improved the symptoms in both cases. These cases highlight that the unexpected transfer of food allergy after CBT can lead to EGIDs, especially in patients receiving T-cell non-depletion GVHD prophylaxis.

    DOI: 10.1016/j.trim.2022.101781

    PubMed

  • 同種造血幹細胞移植後の閉塞性細気管支炎症候群患者における確定したCOVID-19関連肺アスペルギルス症のリポソーム型アムホテリシンBを用いた治療成功(Successful treatment of proven coronavirus disease 2019-associated pulmonary aspergillosis with liposomal amphotericin B in a patient with bronchiolitis obliterans syndrome after allogeneic hematopoietic stem cell transplantation)

    Nakaya Yosuke, Nakashima Yasuhiro, Harada Naonori, Yamada Koichi, Makuuchi Yosuke, Kuno Masatomo, Takakuwa Teruhito, Okamura Hiroshi, Nanno Satoru, Nishimoto Mitsutaka, Koh Hideo, Nakagama Yu, Kido Yasutoshi, Kanno Takayuki, Suzuki Tadaki, Nakamae Hirohisa, Kakeya Hiroshi, Hino Masayuki

    Journal of Infection and Chemotherapy   29 ( 2 )   223 - 227   2023.02( ISSN:1341-321X

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    症例は29歳女性で、発熱、息切れ、持続性の乾性咳嗽で当科を受診した。SARS-CoV-2の抗原検査が陽性であり、胸部CTで両側のすりガラス陰影が認められたことから、COVID-19治療のために隔離病棟に入院した。4年前に急性骨髄性白血病の治療で父親からHLA半合致同種造血幹細胞移植を受けていた。白血病は完全寛解に至ったが、造血幹細胞移植から1年半後に閉塞性細気管支炎症候群を発症したため、プレドニゾロンを内服していた。入院後、生存ウイルスの排出を伴わないSARS-CoV-2のRT-PCR陽性の遷延(COVID-19発症後133日)が認められたが、COVID-19をファビピラビル、レムデシビル、デキサメタゾン、エノキサパリンで治療した。しかし、呼吸状態が悪化し、7日目の胸部CTで中心部まで広がるすりガラス陰影と両肺に厚い空洞が多数出現した。気管支肺胞洗浄の培養と肺生検により新型コロナウイルス感染症関連肺アスペルギルス症と診断した。トリアゾール系薬剤(ボリコナゾール、イトラコナゾール、ポサコナゾール)とエキノカンジン系薬剤(カスポファンギン、ミカファンギン)の併用療法には反応しなかったが、合計16週間のリポソーム型アムホテリシンB療法により良好な反応が得られ、213日目に退院した。

  • Salvage Human Leukocyte Antigen-Haploidentical Hematopoietic Cell Transplant With Posttransplant Cyclophosphamide for Graft Failure in a Patient With Chronic Active Epstein-Barr Virus Infection.

    Nakaya Y, Koh H, Harada N, Okamura H, Misugi T, Suekane T, Tachibana D, Kimura H, Hino M, Nakamae H

    Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation   21 ( 2 )   184 - 188   2023.02( ISSN:1304-0855

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    Authorship:Last author   International / domestic magazine:International journal  

    DOI: 10.6002/ect.2022.0322

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  • Recapitulated Late-Onset Inflammatory Toxicities and Progressive Dysautonomia with Persistence of Central Memory CD4+ Chimeric Antigen Receptor T Cells in a Case of Transformed Follicular Lymphoma: Case Report.

    Nishimoto M, Takakuwa T, Kuno M, Makuuchi Y, Okamura H, Nakashima Y, Koh H, Namba H, Itoh Y, Hino M, Nakamae H

    Acta haematologica   146 ( 4 )   338 - 342   2023( ISSN:0001-5792

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    DOI: 10.1159/000530743

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  • Prognostic impact of complex karyotype on post-transplant outcomes of myelofibrosis.

    Okada Y, Takenaka K, Murata M, Shimazu Y, Tachibana T, Ozawa Y, Uchida N, Wakayama T, Doki N, Sugio Y, Tanaka M, Masuko M, Kobayashi H, Ino K, Ishikawa J, Nakamae H, Matsuoka KI, Kanda Y, Fukuda T, Atsuta Y, Nagamura-Inoue T

    Hematological oncology   40 ( 5 )   1076 - 1085   2022.12( ISSN:0278-0232

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    International / domestic magazine:International journal  

    DOI: 10.1002/hon.3058

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  • Haploidentical transplantation with post-transplant cyclophosphamide versus single cord blood transplantation for myelodysplastic syndrome: A retrospective study from the Adult Myelodysplastic Syndrome Working Group of the Japanese Society for Transplantation and Cellular Therapy (JSTCT).

    Konuma T, Shimomura Y, Ishiyama K, Ara T, Nakamae H, Hiramoto N, Eto T, Maruyama Y, Nagafuji K, Ishikawa J, Uchida N, Tanaka M, Onizuka M, Ueda Y, Anzai N, Kimura T, Kanda Y, Fukuda T, Atsuta Y

    American journal of hematology   97 ( 12 )   E447 - E450   2022.12( ISSN:0361-8609

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    International / domestic magazine:International journal  

    DOI: 10.1002/ajh.26722

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  • Comparable survival outcomes with haploidentical stem cell transplantation and unrelated bone marrow transplantation.

    Atsuta Y, Sugita J, Nakamae H, Maruyama Y, Ishiyama K, Shiratori S, Fukuda T, Kurata M, Shingai N, Ozawa Y, Masuko M, Nagafuji K, Takada S, Kako S, Kanda Y, Kanda J, Ichinohe T, Teshima T

    Bone marrow transplantation   57 ( 12 )   1781 - 1787   2022.12( ISSN:0268-3369

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    International / domestic magazine:International journal  

    DOI: 10.1038/s41409-022-01822-3

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  • Severe short-term adverse events in related bone marrow or peripheral blood stem cell donors.

    Yanagisawa R, Hirakawa T, Doki N, Ikegame K, Matsuoka KI, Fukuda T, Nakamae H, Ota S, Hiramoto N, Ishikawa J, Ara T, Tanaka M, Koga Y, Kawakita T, Maruyama Y, Kanda Y, Hino M, Atsuta Y, Yabe H, Tsukada N

    International journal of hematology   2022.11( ISSN:0925-5710

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    International / domestic magazine:International journal  

    DOI: 10.1007/s12185-022-03489-4

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  • Identifying the optimal conditioning intensity for stem cell transplantation in patients with myelodysplastic syndrome: a machine learning analysis.

    Shimomura Y, Komukai S, Kitamura T, Sobue T, Kurosawa S, Doki N, Katayama Y, Ozawa Y, Matsuoka KI, Tanaka T, Kako S, Sawa M, Kanda Y, Nakamae H, Nakazawa H, Ueda Y, Kanda J, Fukuda T, Atsuta Y, Ishiyama K

    Bone marrow transplantation   2022.11( ISSN:0268-3369

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    International / domestic magazine:International journal  

    DOI: 10.1038/s41409-022-01871-8

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  • Successful treatment of proven coronavirus disease 2019-associated pulmonary aspergillosis with liposomal amphotericin B in a patient with bronchiolitis obliterans syndrome after allogeneic hematopoietic stem cell transplantation.

    Yosuke Nakaya, Yasuhiro Nakashima, Naonori Harada, Koichi Yamada, Yosuke Makuuchi, Masatomo Kuno, Teruhito Takakuwa, Hiroshi Okamura, Satoru Nanno, Mitsutaka Nishimoto, Hideo Koh, Yu Nakagama, Yasutoshi Kido, Takayuki Kanno, Tadaki Suzuki, Hirohisa Nakamae, Hiroshi Kakeya, Masayuki Hino

    Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy   2022.11( ISSN:1341-321X

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    Coronavirus disease 2019 (COVID-19)-associated pulmonary aspergillosis (CAPA) is being increasingly recognized as a severe complication that contributes to poor prognoses among patients with COVID-19. However, little is known regarding the clinical course of CAPA with hematological malignancies, especially after allogeneic hematopoietic stem cell transplantation (HSCT). A 29-year-old woman was diagnosed with proven CAPA with an Aspergillus fumigatus identified by cultures of bronchoalveolar lavage and lung biopsy four years after haploidentical HSCT for acute myelogenous leukemia. She had been taking oral prednisolone for bronchiolitis obliterans syndrome that developed after HSCT. Although prolonged RT-PCR positivity for SARS-CoV-2 (133 days after the onset of COVID-19) without shedding of viable virus was observed, the COVID-19 was treated with favipiravir, remdesivir, dexamethasone, and enoxaparin. However, the CAPA did not respond to combination therapy, which included triazole (voriconazole, itraconazole, posaconazole) and echinocandin (caspofungin, micafungin), even though the Aspergillus fumigatus isolate was found to be susceptible to these agents in vitro. Nevertheless, a total of 16 weeks of liposomal amphotericin B (L-AMB) therapy led to a favorable response, and the patient was discharged from the hospital on day 213. This case provided essential experience of CAPA treated with L-AMB in a recipient with chronic respiratory disease after HSCT.

    DOI: 10.1016/j.jiac.2022.10.020

    PubMed

  • Intramural esophageal hematoma precipitated by acquired factor XI deficiency in a patient with relapsed T cell prolymphocytic leukemia after allogeneic hematopoietic cell transplantation.

    Harada N, Makuuchi Y, Kuno M, Takakuwa T, Okamura H, Nishimoto M, Nakashima Y, Koh H, Bingo M, Higashimori A, Fujiwara Y, Hino M, Nakamae H

    Annals of hematology   101 ( 11 )   2567 - 2569   2022.11( ISSN:0939-5555

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    Authorship:Last author   International / domestic magazine:International journal  

    DOI: 10.1007/s00277-022-04970-0

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  • Comparable survival outcomes with haploidentical stem cell transplantation and cord blood transplantation.

    Junichi Sugita, Yoshiko Atsuta, Hirohisa Nakamae, Yumiko Maruyama, Ken Ishiyama, Souichi Shiratori, Takahiro Fukuda, Mio Kurata, Naoki Shingai, Yukiyasu Ozawa, Masayoshi Masuko, Koji Nagafuji, Naoyuki Uchida, Masatsugu Tanaka, Makoto Onizuka, Junya Kanda, Takafumi Kimura, Tatsuo Ichinohe, Takanori Teshima

    Bone marrow transplantation   57 ( 11 )   1681 - 1688   2022.11( ISSN:0268-3369

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    HLA-haploidentical stem cell transplantation using post-transplant cyclophosphamide (PTCy-haplo) and umbilical cord blood transplantation (UCBT) are alternative to HLA-matched stem cell transplantation. We conducted a matched-pair analysis of PTCy-haplo and UCBT using the Japanese registry data. We identified 136 patients aged between 16 and 69 years who received PTCy-haplo as their first transplantation for acute leukemia or myelodysplastic syndromes. Control group included 408 UCBT recipients selected to match the PTCy-haplo group. Overall and relapse-free survival probabilities at 2 years were comparable between the PTCy-haplo and UCBT groups: 55% vs. 53% for overall survival (p = 0.46), and 47% vs. 48% for relapse-free survival (p = 0.79), respectively. The cumulative incidence of relapse was significantly higher (43% vs. 29%, respectively, p = 0.006), while the cumulative incidence of non-relapse mortality (NRM) was significantly lower (9% vs. 23%, respectively, p < 0.001) in the PTCy-haplo group. The cumulative incidence of grade II-IV acute graft-versus-host disease (GVHD) was lower in the PTCy-haplo group compared to the UCBT group (29% vs. 41%, respectively, p = 0.016), while those of grade III-IV acute GVHD and chronic GVHD were not statistically different between the two groups. Our results suggest that both PTCy-haplo and UCBT are viable alternatives to HLA-matched stem cell transplantation.

    DOI: 10.1038/s41409-022-01770-y

    PubMed

  • Favorable Outcome with Conditioning Regimen of Flu/Bu4/Mel in Acute Myeloid Leukemia Patients in Remission Undergoing Cord Blood Transplantation.

    Mizuno S, Takami A, Kawamura K, Shimomura Y, Arai Y, Konuma T, Ozawa Y, Sawa M, Ota S, Takahashi S, Anzai N, Hiramoto N, Onizuka M, Nakamae H, Tanaka M, Murata M, Kimura T, Kanda J, Fukuda T, Atsuta Y, Yanada M

    Transplantation and cellular therapy   28 ( 11 )   775.e1 - 775.e9   2022.11( ISSN:26666367

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    International / domestic magazine:International journal  

    DOI: 10.1016/j.jtct.2022.07.026

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  • Comparison of transplant outcomes between haploidentical transplantation and single cord blood transplantation in non-remission acute myeloid leukaemia: A nationwide retrospective study.

    Matsuda K, Konuma T, Fuse K, Masuko M, Kawamura K, Hirayama M, Uchida N, Ikegame K, Wake A, Eto T, Doki N, Miyakoshi S, Tanaka M, Takahashi S, Onizuka M, Kato K, Kimura T, Ichinohe T, Takayama N, Kobayashi H, Nakamae H, Atsuta Y, Kanda J, Yanada M

    British journal of haematology   2022.10( ISSN:0007-1048

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    International / domestic magazine:International journal  

    DOI: 10.1111/bjh.18530

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  • Intensified conditioning regimens improved disease-free survival and engraftment after unrelated single-unit cord blood transplantation but not after matched sibling or matched unrelated donor allogeneic hematopoietic cell transplantation.

    Konuma T, Kanda J, Uchida N, Nishijima A, Tanaka M, Ozawa Y, Sawa M, Onizuka M, Ota S, Maruyama Y, Kanda Y, Kawakita T, Ara T, Eto T, Nakamae H, Kimura T, Fukuda T, Atsuta Y, Donor/Source Working Group of theJapanese Society for Transplantation and Cellular Therapy

    Hematological oncology   2022.10( ISSN:0278-0232

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    International / domestic magazine:International journal  

    DOI: 10.1002/hon.3094

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  • BNT162b2 COVID-19ワクチン接種後に温式自己免疫性溶血性貧血とIgM-M蛋白血症を発症した脾辺縁帯リンパ腫

    曽我部 信広, 久野 雅智, 中釜 悠, 幕内 陽介, 原田 尚憲, 高桑 輝人, 岡村 浩史, 廣瀬 朝生, 西本 光孝, 中嶋 康博, 康 秀男, 中前 美佳, 城戸 康年, 中前 博久, 日野 雅之

    臨床血液   63 ( 10 )   1379 - 1385   2022.10( ISSN:0485-1439

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  • B細胞性急性リンパ芽球性白血病に対する自家幹細胞移植と同種幹細胞移植を比較した傾向スコアマッチング/再重み付け分析(Propensity score matching/reweighting analysis comparing autologous and allogeneic stem cell transplantation for B-lineage acute lymphoblastic leukemia)

    Mizuta Shuichi, Ugai Tomotaka, Kato Harumi, Doki Noriko, Ota Shuichi, Kawakita Toshiro, Katayama Yuta, Kurokawa Mineo, Nakamae Hirohisa, Yano Shingo, Nawa Yuichiro, Kanda Yoshinobu, Fukuda Takahiro, Atsuta Yoshiko, Kako Shinichi

    International Journal of Hematology   116 ( 3 )   393 - 400   2022.09( ISSN:0925-5710

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    International / domestic magazine:International journal  

    イノツズマブ・オゾガマイシンや二重特異性抗体ブリナツモマブの登場を背景として、フィラデルフィア染色体陰性B細胞性急性リンパ芽球性白血病(ALL)患者に対する自家幹細胞移植(SCT)の潜在的役割について検討した。初回完全寛解(CR)達成後に同種SCT(allo-SCT)を受けた486例(年齢16~85歳)と自家SCT(auto-SCT)を受けた99例(年齢16~63歳)を比較した。ベースライン特性の不均衡を補正するために、傾向スコアマッチング(PS)と逆確率重み付け法(IPTW)を適用した。その結果、PSマッチングを行ったコホートにおける5年全生存率(OS)はallo-SCT群では57%(95%CI 46~67%)、auto-SCT群では44%(95%CI 33~54%)であった。多変量解析、傾向スコアマッチング解析、およびIPTW解析のいずれにおいても、両群間のOSに統計学的有意差は認められなかった(ハザード比[HR]0.81、95%CI 0.53~1.27、p=0.36;HR 0.84、95%CI 0.40~1.78、p=0.65;HR 0.71、95%CI 0.25~2.02、p=0.53)。以上より、自家移植の可能性について検討するために、治療オプションとして自家移植を含む前方視的試験が必要であると考えられた。

  • Polatuzumab vedotin combined with rituximab-bendamustine immediately before stem cell mobilization in relapsed diffuse large B-cell lymphoma.

    Takakuwa T, Okayama Y, Nakamae H, Kuno M, Makuuchi Y, Harada N, Okamura H, Nishimoto M, Nakashima Y, Koh H, Hino M

    Annals of hematology   101 ( 7 )   1609 - 1610   2022.07( ISSN:0939-5555

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    International / domestic magazine:International journal  

    DOI: 10.1007/s00277-022-04803-0

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  • Immunomodulatory and direct activities of ropeginterferon alfa-2b on cancer cells in mouse models of leukemia.

    Kazuki Sakatoku, Yasuhiro Nakashima, Joji Nagasaki, Mitsutaka Nishimoto, Asao Hirose, Mika Nakamae, Hideo Koh, Masayuki Hino, Hirohisa Nakamae

    Cancer science   113 ( 7 )   2246 - 2257   2022.07( ISSN:1347-9032

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    Authorship:Last author   Publishing type:Research paper (scientific journal)   International / domestic magazine:International journal  

    Although ropeginterferon alfa-2b has recently been clinically applied to myeloproliferative neoplasms with promising results, its antitumor mechanism has not been thoroughly investigated. Using a leukemia model developed in immunocompetent mice, we evaluated the direct cytotoxic effects and indirect effects induced by ropeginterferon alfa-2b in tumor cells. Ropeginterferon alfa-2b therapy significantly prolonged the survival of mice bearing leukemia cells and led to long-term remission in some mice. Alternatively, conventional interferon-alpha treatment slightly extended the survival and all mice died. When ropeginterferon alfa-2b was administered to interferon-alpha receptor 1-knockout mice after the development of leukemia to verify the direct effect on the tumor, the survival of these mice was slightly prolonged; nevertheless, all of them died. In vivo CD4+ or CD8+ T-cell depletion resulted in a significant loss of therapeutic efficacy in mice. These results indicate that the host adoptive immunostimulatory effect of ropeginterferon alfa-2b is the dominant mechanism through which tumor cells are suppressed. Moreover, mice in long-term remission did not develop leukemia, even after tumor rechallenge. Rejection of rechallenge tumors was canceled only when both CD4+ and CD8+ T cells were removed in vivo, which indicates that each T-cell group functions independently in immunological memory. We show that ropeginterferon alfa-2b induces excellent antitumor immunomodulation in hosts. Our finding serves in devising therapeutic strategies with ropeginterferon alfa-2b.

    DOI: 10.1111/cas.15376

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  • Outcomes of salvage haploidentical transplantation using posttransplant cyclophosphamide for graft failure following allogeneic hematopoietic stem cell transplantation.

    Harada K, Najima Y, Kato M, Fuji S, Shinohara A, Nakamae H, Toyosaki M, Ashiarai M, Onizuka M, Hashii Y, Ichinohe T, Atsuta Y, Nakasone H

    International journal of hematology   2022.06( ISSN:0925-5710

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    International / domestic magazine:International journal  

    DOI: 10.1007/s12185-022-03405-w

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  • Registry data analysis of hematopoietic stem cell transplantation on systemic chronic active Epstein-Barr virus infection patients in Japan.

    Yamamoto M, Sato M, Onishi Y, Sasahara Y, Sano H, Masuko M, Nakamae H, Matsuoka KI, Ara T, Washio K, Onizuka M, Watanabe K, Takahashi Y, Hirakawa T, Nishio M, Sakashita C, Kobayashi T, Sawada A, Ichinohe T, Fukuda T, Hashii Y, Atsuta Y, Arai A

    American journal of hematology   97 ( 6 )   780 - 790   2022.06( ISSN:0361-8609

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    International / domestic magazine:International journal  

    DOI: 10.1002/ajh.26544

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  • Allogeneic Hematopoietic Stem Cell Transplantation for Adult Philadelphia Chromosome-Negative B-Cell Acute Lymphoblastic Leukemia in Second Complete Remission.

    Kaito S, Kurosawa S, Najima Y, Sakaida E, Shingai N, Fukuda T, Tachibana T, Uchida N, Ozawa Y, Sawa M, Nakazawa H, Ota S, Kato J, Nakamae H, Katayama Y, Eto T, Tanaka J, Kanda Y, Atsuta Y, Arai Y, Kako S, Adult Acute Lymphoblastic Leukemia Working Group of the Japan Society for Hematopoietic Cell Transplantation.

    Transplantation and cellular therapy   28 ( 6 )   326.e1 - 326.e10   2022.06( ISSN:2666-6375

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    International / domestic magazine:International journal  

    DOI: 10.1016/j.jtct.2022.03.017

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  • Phagocytosis of Mature Granulocytes by Bone Marrow Macrophages in an Elderly Man with Adult-Onset Primary Autoimmune Neutropenia.

    Nishimoto M, Nakane T, Koh H, Nakashima Y, Yamamura R, Nakamae H, Hino M, Ohta K

    Hematology reports   14 ( 2 )   165 - 171   2022.05( ISSN:2038-8322

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    International / domestic magazine:International journal  

    DOI: 10.3390/hematolrep14020024

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  • Propensity score matching/reweighting analysis comparing autologous and allogeneic stem cell transplantation for B-lineage acute lymphoblastic leukemia.

    Shuichi Mizuta, Tomotaka Ugai, Harumi Kato, Noriko Doki, Shuichi Ota, Toshiro Kawakita, Yuta Katayama, Mineo Kurokawa, Hirohisa Nakamae, Shingo Yano, Yuichiro Nawa, Yoshinobu Kanda, Takahiro Fukuda, Yoshiko Atsuta, Shinichi Kako

    International journal of hematology   2022.05( ISSN:0925-5710

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    Publishing type:Research paper (scientific journal)   International / domestic magazine:International journal  

    We compared the outcomes of autologous stem cell transplantation (auto-SCT) with those of allogeneic stem cell transplantation (allo-SCT) from a human leukocyte antigen-matched related donor in patients with Philadelphia chromosome-negative B-lineage acute lymphoblastic leukemia (ALL). Newly diagnosed patients who underwent allo-SCT (n = 486) or auto-SCT (n = 99) after achieving first complete remission (CR) were included. Propensity score matching (PS) and an inverse probability of the treatment weighting (IPTW) analysis were applied to compensate for imbalances in baseline characteristics. The 5 years rates of overall survival (OS) among those in the PS-matched cohorts were 57% [95% confidence interval (CI) 46-67%] for those who received allo-SCT and 44% (95% CI 33-54%) for those who received auto-SCT. Multivariable, propensity score-matched, and IPTW analyses all revealed no statistically significant differences in OS between the two groups [hazard ratios (HR) 0.81, 95% CI 0.53-1.27, p = 0.36; HR 0.84, 95% CI 0.40-1.78, p = 0.65; HR 0.71, 95% CI 0.25-2.02, p = 0.53, respectively]. Prospective trials that include autologous transplantation as a treatment option are needed to examine the potential of autologous transplantation.

    DOI: 10.1007/s12185-022-03368-y

    PubMed

  • The new generation tyrosine kinase inhibitor improves the survival of chronic myeloid leukemia patients after allogeneic stem cell transplantation.

    Shimazu Y, Murata M, Kondo T, Minami Y, Tachibana T, Doki N, Uchida N, Ozawa Y, Yano S, Fukuda T, Kato J, Ara T, Eto T, Ishikawa J, Nakamae H, Tanaka J, Ichinohe T, Atsuta Y, Nagamura-Inoue T, working group of the Japan Society for Transplantation and Cellular Therapy.

    Hematological oncology   2022.04( ISSN:0278-0232

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    International / domestic magazine:International journal  

    DOI: 10.1002/hon.3000

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  • Risk factors and prognosis of non-infectious pulmonary complications after allogeneic hematopoietic stem cell transplantation.

    Makoto Onizuka, Nobuharu Fujii, Hideki Nakasone, Masao Ogata, Yoshiko Atsuta, Ritsuro Suzuki, Naoyuki Uchida, Kazuteru Ohashi, Yukiyasu Ozawa, Tetsuya Eto, Kazuhiro Ikegame, Hirohisa Nakamae, Masami Inoue, Takahiro Fukuda

    International journal of hematology   115 ( 4 )   534 - 544   2022.04( ISSN:0925-5710

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    Non-infectious pulmonary complications (NIPCs) following allogeneic hematopoietic stem cell transplantation (HSCT) are relatively rare, but frequently fatal. This study investigated the pre-transplant risk factors for developing NIPCs using Japanese transplant registry database entries from 2001 to 2009. Among 13,573 eligible patients, 535 experienced NIPCs (3.9%). Multivariate analysis identified high recipient age (60 + years: HR 1.85, P = 0.003), HLA mismatch (HR 1.61, P < 0.001), female to male HSCT (HR 1.54, P < 0.001), and unrelated bone marrow transplantation (UR-BMT) (HR 3.88, P < 0.001) as significantly associated with an increased risk of NIPCs. In contrast, a non-total body irradiation (TBI) regimen with reduced intensity conditioning (RIC) were associated with a decreased risk of NIPCs compared with a cyclophosphamide (CY) + TBI regimen (busulfan + CY: HR 0.67, P = 0.009, other non-TBI: HR 0.46, P < 0.001), fludarabine-based RIC (HR 0.52, P < 0.001), and other RIC (HR 0.42, P = 0.003). The mortality rate was significantly worse for patients with NIPCs than those without (HR 1.54, 71 P < 0.001). This large-scale retrospective study suggests that both allo-reactions to donor cells and conditioning regimen toxicity contributed to NIPCs following HSCT.

    DOI: 10.1007/s12185-021-03282-9

    PubMed

  • Risk and Predictive Factors for Candidemia After Allogeneic Hematopoietic Cell Transplantation: JSTCT Transplant Complications Working Group.

    Kimura SI, Kameda K, Harada K, Saburi M, Okinaka K, Shinohara A, Uchida N, Nishijima A, Ozawa Y, Tanaka M, Kuriyama T, Katayama Y, Sawa M, Ikegame K, Kawakita T, Kanda Y, Nakamae H, Ara T, Kimura T, Sato A, Fukuda T, Atsuta Y, Nakasone H

    Transplantation and cellular therapy   28 ( 4 )   209.e1 - 209.e9   2022.04( ISSN:2666-6375

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    International / domestic magazine:International journal  

    DOI: 10.1016/j.jtct.2021.12.020

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  • 同種造血幹細胞移植後の非感染性肺合併症の危険因子と予後(Risk factors and prognosis of non-infectious pulmonary complications after allogeneic hematopoietic stem cell transplantation)

    Onizuka Makoto, Fujii Nobuharu, Nakasone Hideki, Ogata Masao, Atsuta Yoshiko, Suzuki Ritsuro, Uchida Naoyuki, Ohashi Kazuteru, Ozawa Yukiyasu, Eto Tetsuya, Ikegame Kazuhiro, Nakamae Hirohisa, Inoue Masami, Fukuda Takahiro, the Transplant Complications Working Group of the Japan Society for Hematopoietic Cell Transplantation

    International Journal of Hematology   115 ( 4 )   534 - 544   2022.04( ISSN:0925-5710

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    同種造血幹細胞移植後の非感染性肺合併症(NIPC)発症の危険因子と合併症に伴う死亡率を評価するため、症例対照研究を実施した。2001年から2009年までの日本の造血幹細胞移植登録一元管理プログラム(TRUMP)に登録された13573例のうち、535例がNIPCを発症した(3.9%)。多変量解析により、レシピエントの年齢が高い(60歳以上:ハザード比[HR] 1.85、p=0.003)、HLAミスマッチ(HR 1.61、P<0.001)、女性から男性への造血幹細胞移植(HR 1.54、p<0.001)、および非血縁骨髄移植(HR 3.88、p<0.001)はNIPCリスクの増加と有意に関連していた。非全身照射(TBI)レジメン+強度減弱前処置(RIC)は、シクロホスファミド(CY)+TBIレジメン(ブスルファン+CY:HR 0.67、P=0.009)、その他の非TBI(HR 0.46、p<0.001)、フルダラビンベースRIC(HR 0.52、p<0.001)、その他のRIC(HR 0.42、p=0.003)と比べてNIPCリスクが減少していた。死亡率は、NIPCを有する患者の方が、有さない患者よりも有意に悪かった(HR 1.54、p<0.001)。以上より、ドナー細胞に対するアロ反応と移植前処置の毒性の両方が造血幹細胞移植後のNIPCに寄与することが示唆された。

  • Predictive value of clinical examination parameters for cardiovascular adverse events during treatment of chronic myeloid leukemia with tyrosine kinase inhibitors.

    Nakamae M, Nakamae H, Hashimoto M, Koh H, Nakashima Y, Hirose A, Hino M

    International journal of hematology   115 ( 3 )   329 - 335   2022.03( ISSN:0925-5710

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    Authorship:Corresponding author  

    DOI: 10.1007/s12185-021-03259-8

    PubMed

  • Predictive value of clinical examination parameters for cardiovascular adverse events during treatment of chronic myeloid leukemia with tyrosine kinase inhibitors(和訳中)

    Nakamae Mika, Nakamae Hirohisa, Hashimoto Mika, Koh Hideo, Nakashima Yasuhiro, Hirose Asao, Hino Masayuki

    International Journal of Hematology   115 ( 3 )   329 - 335   2022.03( ISSN:0925-5710

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    International / domestic magazine:International journal  

  • Delayed immune-related neutropenia with hepatitis by pembrolizumab.

    Nakako S, Nakashima Y, Okamura H, Tani Y, Ueda T, Makuuchi Y, Kuno M, Takakuwa T, Nishimoto M, Koh H, Nakamae H, Hino M

    Immunotherapy   14 ( 2 )   101 - 105   2022.02( ISSN:1750-743X

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    International / domestic magazine:International journal  

    DOI: 10.2217/imt-2021-0131

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  • Cytomegalovirus gastroenteritis in patients with acute graft-versushost disease

    Yu Akahoshi, Shun Ichi Kimura, Yuma Tada, Toshihiro Matsukawa, Masaharu Tamaki, Noriko Doki, Naoyuki Uchida, Masatsugu Tanaka, Hirohisa Nakamae, Takuro Kuriyama, Ken Ichi Matsuoka, Takashi Ikeda, Takafumi Kimura, Takahiro Fukuda, Yoshinobu Kanda, Yoshiko Atsuta, Makoto Murata, Seitaro Terakura, Hideki Nakasone

    Blood Advances   6 ( 2 )   574 - 584   2022.01( ISSN:2473-9529

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    A preemptive strategy has successfully decreased cytomegalovirus (CMV) disease after allogeneic hematopoietic cell transplantation (HCT).However, some recipients still develop CMV gastroenteritis, especially after acute graft-versus-host disease (aGVHD), and its incidence, risk factors, and prognostic impact remain to be elucidated.We retrospectively analyzed 3759 consecutive adult patientswho developed grade II-IV aGVHD using a Japanese registry database. The cumulative incidence of CMV gastroenteritiswas 5.7%by day 365 fromthe development of grade II-IV aGVHD. Advanced age (hazard ratio [HR], 1.60; 95%confidence interval [CI], 1.16-2.22; P=.004), GVHDprophylaxiswithmycophenolate mofetil and calcineurin inhibitor (HR, 1.73; 95%CI, 1.08-2.77; P=.024), lower-gut aGVHD (HR, 2.17; 95%CI, 1.58-2.98; P<.001), and the use of systemic steroids (HR, 1.78; 95%CI, 1.16-2.74; P5.008)were independent risk factors for CMV gastroenteritis. Development of CMV gastroenteritis was associated with an increased risk of nonrelapsemortality (HR, 1.89; 95%CI, 1.50-2.39; P<.001). Moreover, letermovir prophylaxis significantly reduced both the incidence of CMV gastroenteritis (HR, 0.50; 95%CI, 0.25-0.99; P=.047) and the risk of nonrelapsemortality (HR, 0.72; 95%CI, 0.52- 0.99; P=.043). In summary, CMV gastroenteritis is a life-threatening complication that sets the need for preventive strategieswith letermovir and targeted surveillance.

    DOI: 10.1182/bloodadvances.2021005885

    PubMed

  • Outcomes of third allogeneic hematopoietic stem cell transplantation in relapsed/refractory acute leukemia after a second transplantation.

    Kobayashi S, Kanda Y, Konuma T, Inamoto Y, Matsumoto K, Uchida N, Ikegame K, Miyamoto T, Doki N, Nakamae H, Katayama Y, Takahashi S, Shiratori S, Saito S, Kawakita T, Kanda J, Fukuda T, Atsuta Y, Kimura F

    Bone marrow transplantation   57 ( 1 )   43 - 50   2022.01( ISSN:0268-3369

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    International / domestic magazine:International journal  

    DOI: 10.1038/s41409-021-01485-6

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  • Nilotinib vs. imatinib in Japanese patients with newly diagnosed chronic myeloid leukemia in chronic phase: 10-year follow‑up of the Japanese subgroup of the randomized ENESTnd trial.

    Nakamae H, Yamamoto M, Sakaida E, Kanda Y, Ohmine K, Ono T, Matsumura I, Ishikawa M, Aoki M, Maki A, Shibayama H

    International journal of hematology   115 ( 1 )   33 - 42   2022.01( ISSN:0925-5710

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    Authorship:Lead author, Corresponding author   International / domestic magazine:International journal  

    DOI: 10.1007/s12185-021-03216-5

    PubMed

  • High-Dose Chemotherapy With Autologous Stem Cell Transplantation in a Case of Refractory Peripheral T Cell Lymphoma With Tracheoesophageal Fistula: A Case Report.

    Hayashi T, Nakashima Y, Nishimoto M, Nanno S, Naka R, Gyobu K, Lee S, Okamoto S, Hino M, Nakamae H

    Transplantation proceedings   54 ( 1 )   189 - 192   2022.01( ISSN:0041-1345

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    Authorship:Last author   International / domestic magazine:International journal  

    DOI: 10.1016/j.transproceed.2021.10.015

    PubMed

  • Effect of Donor NKG2D Polymorphism on Relapse after Haploidentical Transplantation with Post-Transplantation Cyclophosphamide.

    Ido K, Koh H, Hirose A, Seto T, Makuuchi Y, Kuno M, Takakuwa T, Okamura H, Nanno S, Nakamae M, Nishimoto M, Nakashima Y, Hino M, Nakamae H

    Transplantation and cellular therapy   28 ( 1 )   20.e1 - 20.e10   2022.01( ISSN:2666-6375

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    Authorship:Last author   International / domestic magazine:International journal  

    DOI: 10.1016/j.jtct.2021.09.019

    PubMed

  • A phase II study of post-transplant cyclophosphamide combined with tacrolimus for GVHD prophylaxis after HLA-matched related/unrelated allogeneic hematopoietic stem cell transplantation.

    Nakamae H, Nakane T, Okamura H, Koh H, Nakashima Y, Hirose A, Nakamae M, Nishimoto M, Kuno M, Makuuchi Y, Harada N, Takakuwa T, Hino M

    International journal of hematology   115 ( 1 )   77 - 86   2022.01( ISSN:0925-5710

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    Authorship:Lead author, Corresponding author   International / domestic magazine:International journal  

    DOI: 10.1007/s12185-021-03228-1

    PubMed

  • 急速にMGUSから多発性骨髄腫に進行し多臓器不全を呈した原発性アミロイドーシス

    田添 久実代, 高桑 輝人, 幕内 陽介, 久野 雅智, 原田 尚憲, 岡村 浩史, 西本 光孝, 康 秀男, 中嶋 康博, 中前 博久, 日野 雅之

    臨床血液   63 ( 1 )   31 - 36   2022.01( ISSN:0485-1439

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    International / domestic magazine:Domestic journal  

    意義不明の単クローン性免疫グロブリン血症(MGUS)は通常無症候性であり無治療経過観察が標準治療であるが,年に1.5%の頻度で骨髄腫関連腫瘍に進行する。病勢進行の判断が一般的な検査では困難な場合もあり,今回長期間無症状で,突然の腎機能障害を契機に多発性骨髄腫への病勢進行が判明したMGUSの症例を報告する。症例は66歳女性。IgA-κ型のMGUSの診断に至ってから8年後,急激な腎機能障害を認めて持続的血液濾過透析を要した。精査の結果IgA-κ型の多発性骨髄腫の診断に至り,化学療法が奏効せず,敗血症を合併して第19病日に死亡した。その後,病理解剖で全身アミロイドーシスおよび黄色ブドウ球菌による多発膿瘍の合併が判明した。MGUSの病勢進行のリスクとして遊離軽鎖κ/λ比の異常やM蛋白がIgG以外であることが報告されている。これらのリスクを有する症例では早期診断のために常に病勢進行の可能性を念頭において注意深く観察を行うことが重要である。(著者抄録)

  • A Prospective Study of an HLA-Haploidentical Peripheral Blood Stem Cell Transplantation Regimen Based on Modification of the Dose of Posttransplant Cyclophosphamide for Poor Prognosis or Refractory Hematological Malignancies.

    Nakamae H, Okamura H, Hirose A, Koh H, Nakashima Y, Nakamae M, Nishimoto M, Makuuchi Y, Kuno M, Harada N, Takakuwa T, Hino M

    Cell transplantation   31   9636897221112098   2022.01( ISSN:0963-6897

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    Authorship:Lead author, Corresponding author   International / domestic magazine:International journal  

    DOI: 10.1177/09636897221112098

    PubMed

  • AL amyloidosis presenting with fluminant multiorgan failure accompanied by rapid progression from MGUS to multiple myeloma

    TAZOE Kumiyo, TAKAKUWA Teruhito, MAKUUCHI Yosuke, KUNO Masatomo, HARADA Naonori, OKAMURA Hiroshi, NISHIMOTO Mitsutaka, KOH Hideo, NAKASHIMA Yasuhiro, NAKAMAE Hirohisa, HINO Masayuki

    Rinsho Ketsueki   63 ( 1 )   31 - 36   2022( ISSN:0485-1439

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    International / domestic magazine:Domestic journal  

    <p>Monoclonal gammopathy of undermined significance (MGUS) is usually asymptomatic, and untreated follow-up is the standard treatment. However, MGUS progresses to multiple myeloma or related malignancy at a frequency of 1.5% per year. It is sometimes difficult to diagnose the progression of the disease via usual examinations. We herein report a case wherein rapid renal dysfunction led to a diagnosis of disease progression to multiple myeloma in a patient with MGUS that was asymptomatic for a long time. A 66-year-old woman developed rapid renal dysfunction requiring continuous hemodiafiltration 8 years after the diagnosis of IgA-κ type MGUS. A complete examination led to the diagnosis of IgA-κ type multiple myeloma. Chemotherapy was not effective, and she died due to sepsis on the 19th day of admission. A pathological autopsy revealed systemic amyloidosis and multiple abscesses positive for <i>Staphylococcus aureus</i>. An abnormal free light chain κ/λ ratio and M protein other than IgG are reportedly risk factors of disease progression of MGUS. In cases with these risk factors, it is important to always keep in mind the possibility of disease progression and to monitor the patient carefully for an early diagnosis.</p>

    DOI: 10.11406/rinketsu.63.31

    PubMed

    CiNii Article

  • Warm autoimmune hemolytic anemia and IgM-monoclonal gammopathy following BNT162b2 COVID-19 vaccine in a patient with splenic marginal zone lymphoma

    SOGABE Nobuhiro, KUNO Masatomo, NAKAGAMA Yu, MAKUUCHI Yosuke, HARADA Naonori, TAKAKUWA Teruhito, OKAMURA Hiroshi, HIROSE Asao, NISHIMOTO Mitsutaka, NAKASHIMA Yasuhiro, KOH Hideo, NAKAMAE Mika, KIDO Yasutoshi, NAKAMAE Hirohisa, HINO Masayuki

    Rinsho Ketsueki   63 ( 10 )   1379 - 1385   2022( ISSN:0485-1439

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    International / domestic magazine:Domestic journal  

    <p>There is currently no evidence that a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mRNA vaccine might be associated with the development of autoimmune hemolytic anemia or disease progression in patients with mature B-cell neoplasm. Our patient was a 71-year-old man with indolent mature B-cell neoplasm who had been monitored for many years without treatment. After receiving the second dose of the BNT162b2 mRNA COVID-19 vaccine, he developed severe warm autoimmune hemolytic anemia. Although steroid therapy improved his anemia, he continued to develop IgM-monoclonal gammopathy, renal insufficiency, and splenomegaly. He was diagnosed with splenic marginal zone lymphoma after undergoing splenectomy. The splenectomy improved the patient’s symptoms. We assessed his SARS-CoV-2 specific antibody response, but the patient’s serologic response to the vaccine was impaired. In patients with mature B-cell neoplasm, a non-specific immune response after vaccination might be associated with paraneoplastic syndromes.</p>

    DOI: 10.11406/rinketsu.63.1379

    PubMed

  • Impact of HLA disparity on the risk of overall mortality in patients with grade II-IV acute GVHD on behalf of the HLA Working Group of Japan Society for Hematopoietic Cell Transplantation.

    Shigeo Fuji, Akitoshi Hakoda, Junya Kanda, Makoto Murata, Seitaro Terakura, Yoshihiro Inamoto, Naoyuki Uchida, Takashi Toya, Tetsuya Eto, Hirohisa Nakamae, Kazuhiro Ikegame, Masatsugu Tanaka, Toshiro Kawakita, Tadakazu Kondo, Toshihiro Miyamoto, Takahiro Fukuda, Tatsuo Ichinohe, Takafumi Kimura, Yoshiko Atsuta, Ayumi Shintani, Satoko Morishima

    Bone marrow transplantation   56 ( 12 )   2990 - 2996   2021.12( ISSN:0268-3369

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    Publishing type:Research paper (scientific journal)   International / domestic magazine:International journal  

    Acute graft-versus-host disease (aGVHD) is a major cause of morbidity and mortality after allogeneic hematopoietic cell transplantation (HCT). Stem cell source or HLA disparity may exert a significant impact on the overall survival (OS) after the development of aGVHD. In order to clarify this point, we performed a retrospective analysis using a database of the Japan Society for HCT. We analyzed the clinical outcomes of 10,035 patients who developed grade II-IV aGVHD. The median age of the patients was 48 years. The probability of 2-year OS after the onset of grade II-IV aGVHD in the study cohort was 54.1%. The multivariate analysis showed that the HLA ≥2-loci mismatched related donor and HLA 1-locus mismatched unrelated donor were significantly associated with an inferior OS after grade II-IV aGVHD. In a subgroup analysis, peripheral blood stem cells and HLA disparity were associated with an inferior OS in patients who received related or unrelated HCT. Thus, the clinical outcome after grade II-IV aGVHD significantly varied as per the combination of the presence of HLA disparity and stem cell source. Further research using other databases is necessary to confirm our findings.

    DOI: 10.1038/s41409-021-01443-2

    PubMed

  • Difference in outcomes following allogeneic hematopoietic cell transplantation for patients with acute myeloid leukemia and myelodysplastic syndromes.

    Yanada M, Mizuno S, Yamasaki S, Harada K, Konuma T, Tamaki H, Shingai N, Uchida N, Ozawa Y, Tanaka M, Onizuka M, Sawa M, Nakamae H, Shiratori S, Matsuoka KI, Eto T, Kawakita T, Maruyama Y, Ichinohe T, Kanda Y, Atsuta Y, Aoki J, Yano S

    Leukemia & lymphoma   62 ( 14 )   3411 - 3419   2021.12( ISSN:1042-8194

  • Allogeneic Hematopoietic Cell Transplantation from Alternative Donors in Acute Myeloid Leukemia: A Comparative Analysis.

    Masamitsu Yanada, Takaaki Konuma, Satoshi Yamasaki, Kaito Harada, Makoto Iwasaki, Ayako Kobayashi, Akihiko Nishijima, Masatsugu Tanaka, Naoyuki Uchida, Hirohisa Nakamae, Takahiro Fukuda, Makoto Onizuka, Yukiyasu Ozawa, Masashi Sawa, Yuta Katayama, Satoshi Yoshioka, Takafumi Kimura, Tatsuo Ichinohe, Yoshiko Atsuta, Junya Kanda, Shingo Yano

    Transplantation and cellular therapy   27 ( 12 )   1005.e1 - 1005.e8   2021.12( ISSN:2666-6375

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    Publishing type:Research paper (scientific journal)   International / domestic magazine:International journal  

    BACKGROUND: In the absence of matched related and unrelated donors, an alternative donor has to be found for patients in need of allogeneic hematopoietic cell transplantation (HCT). There are at least three donor options: a mismatched unrelated donor (MMUD), an umbilical cord blood (UCB), and a haploidentical related donor (Haplo); however, the optimal alternative donor selection remains to be established. OBJECTIVES: This study aimed to address how the outcomes of these three alternative donor transplantations differ, and whether the outcomes of each of the alternative donor transplantations have changed over time. STUDY DESIGN: We retrospectively analyzed Japanese nationwide transplantation registry data of adults with acute myeloid leukemia (AML) undergoing allogeneic HCT during first complete remission (CR) from MMUD with a 7/8-match at the allele level (n = 601), UCB, (n = 1110), or Haplo (n = 221) between 2007 and 2018. RESULTS: For patients transplanted from 2007 to 2014, the 3-year overall survival (OS) for the MMUD, UCB, and Haplo groups was 60%, 54%, and 47%, respectively (P = 0.022). For those transplanted from 2015 to 2018, the 3-year OS was 60%, 66%, and 63%, respectively (P = 0.693). Multivariate analysis revealed that the risks of both overall mortality and non-relapse mortality (NRM) were significantly lower in the later period than in the earlier period in the UCB group [hazard ratio (HR), 0.66; P < 0.001 for OS; and HR, 0.64; P < 0.001 for NRM], and in the Haplo group (HR, 0.58; P = 0.019 for OS; HR, 0.39; P = 0.004 for NRM), but not in the MMUD group (HR, 1.07; P = 0.631 for OS; HR, 1.26; P = 0.175 for NRM). The results of a test for interaction showed a significant difference in the effect of the transplantation period on OS and NRM between the MMUD and UCB groups (P = 0.014 for OS and P = 0.004 for NRM) and between the MMUD and Haplo groups (P = 0.034 for OS and P = 0.003 for NRM). CONCLUSION: These findings demonstrate the recent improvements in the outcomes of UCB and Haplo transplantations in patients with AML in first CR, consequently resulting in the similar OS of patients transplanted from MMUD, UCB, and Haplo in the later period.

    DOI: 10.1016/j.jtct.2021.08.027

    PubMed

  • Cytomegalovirus reactivation is associated with an increased risk of late-onset invasive aspergillosis independently of grade II-IV acute graft-versus-host disease in allogeneic hematopoietic stem cell transplantation: JSTCT Transplant Complications Working Group.

    Shun-Ichi Kimura, Masaharu Tamaki, Keiji Okinaka, Sachiko Seo, Naoyuki Uchida, Aiko Igarashi, Yukiyasu Ozawa, Kazuhiro Ikegame, Tetsuya Eto, Masatsugu Tanaka, Souichi Shiratori, Hirohisa Nakamae, Masashi Sawa, Toshiro Kawakita, Makoto Onizuka, Takahiro Fukuda, Yoshiko Atsuta, Yoshinobu Kanda, Hideki Nakasone

    Annals of hematology   100 ( 12 )   3029 - 3038   2021.12( ISSN:0939-5555

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    Publishing type:Research paper (scientific journal)   International / domestic magazine:International journal  

    There is a matter of debate about the clinical impact of cytomegalovirus (CMV) reactivation on the development of late-onset invasive aspergillosis (IA), which occurs 40 days or later after allogeneic hematopoietic stem cell transplantation (HSCT). Using a Japanese transplant registry database, we analyzed the risk factors for the development of late-onset IA in 21,015 patients who underwent their first allogeneic HSCT between 2006 and 2017. CMV reactivation was defined as the initiation of preemptive anti-CMV antiviral therapy. Overall, there were 582 cases of late-onset IA, which occurred at a median of 95 days after HSCT. The 2-year cumulative incidence was 3.4% (95% confidence interval (CI), 3.0-3.9) in patients with CMV reactivation within 40 days after HSCT and 2.5% (95% CI, 2.3-2.8) in those without it (P < 0.001). In a multivariate analysis, CMV reactivation as a time-dependent covariate was significantly associated with the development of late-onset IA (hazard ratio (HR) 1.40, P < 0.001), as well as grade II-IV acute GVHD, age > 50 and HCT-CI ≥ 3 in the entire cohort. If we focus on the subgroup without grade II-IV acute GVHD, which is generally an indication for systemic corticosteroid therapy (n = 12,622), CMV reactivation was still a significant factor for the development of late-onset IA (HR 1.37, P = 0.045) as well as age > 50 years, HCT-CI ≥ 3, and cord blood transplantation. In conclusion, CMV reactivation was associated with an increased risk of late-onset IA after allogeneic HSCT independently of acute GVHD. Close monitoring for late-onset IA is necessary for patients who develop CMV reactivation even without grade II-IV acute GVHD.

    DOI: 10.1007/s00277-021-04660-3

    PubMed

  • Peritransplant glucocorticoids redistribute donor T cells to the bone marrow and prevent relapse after haploidentical SCT.

    Inoue T, Koyama M, Kaida K, Ikegame K, Ensbey KS, Samson L, Takahashi S, Zhang P, Minnie SA, Maruyama S, Ishii S, Daimon T, Fukuda T, Nakamae H, Ara T, Maruyama Y, Ishiyama K, Ichinohe T, Atsuta Y, Blazar BR, Furlan SN, Ogawa H, Hill GR

    JCI insight   6 ( 22 )   2021.11

  • Increasing numbers of CD19 + CD24<sup>high</sup>CD38<sup>high</sup> regulatory B cells and pre-germinal center B cells reflect activated autoimmunity and predict future treatment response in patients with untreated immune thrombocytopenia.

    Hayashi T, Nakamae H, Takeda S, Nakashima Y, Koh H, Nishimoto M, Okamura H, Nanno S, Makuuchi Y, Kuno M, Nakamae M, Hirose A, Hino M

    International journal of hematology   114 ( 5 )   580 - 590   2021.11( ISSN:0925-5710

  • A Phase I/II Multicenter Trial of HLA-Haploidentical PBSCT with PTCy for Aggressive Adult T Cell Leukemia/Lymphoma.

    Tanaka T, Nakamae H, Ito A, Fuji S, Hirose A, Eto T, Henzan H, Takase K, Yamasaki S, Makiyama J, Moriuchi Y, Choi I, Nakano N, Hiramoto N, Kato K, Sato T, Sawayama Y, Kim SW, Inoue Y, Inamoto Y, Fukuda T

    Transplantation and cellular therapy   27 ( 11 )   928.e1 - 928.e7   2021.11( ISSN:26666367

  • 未治療の免疫性血小板減少症患者におけるCD19+ CD24high CD38high制御性B細胞およびプレ胚中心B細胞の増加は、活性化した自己免疫を反映し、将来の治療反応を予測する(Increasing numbers of CD19+CD24high CD38high regulatory B cells and pre-germinal center B cells reflect activated autoimmunity and predict future treatment response in patients with untreated immune thrombocytopenia)

    Hayashi Tetsuya, Nakamae Hirohisa, Takeda Shinichi, Nakashima Yasuhiro, Koh Hideo, Nishimoto Mitsutaka, Okamura Hiroshi, Nanno Satoru, Makuuchi Yosuke, Kuno Masatomo, Nakamae Mika, Hirose Asao, Hino Masayuki

    International Journal of Hematology   114 ( 5 )   580 - 590   2021.11( ISSN:0925-5710

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    免疫性血小板減少症(ITP)の病態をさらに解明するため、未治療ITP患者の末梢血中のリンパ球サブセットとサイトカイン血清レベルや血小板関連IgG(PAIgG)抗体価との関連を検討した。ITP患者では、健常対照者と比較して、CD19+ CD24high CD38high制御性B細胞、プレ胚中心B細胞、およびプラズマブラスト様B細胞の割合が有意に高かった。制御性B細胞およびプレ胚中心B細胞の絶対数は、二次治療が必要なITP患者で有意に高かった。さらに、血清中の腫瘍壊死因子ファミリーに属するB細胞活性化因子腫瘍壊死因子(BAFF)レベルおよび血小板関連免疫グロブリンG抗体価は、制御性B細胞、プレ胚中心B細胞、および自己応答性B細胞の細胞数と正の相関があった。血清インターフェロンα(IFNα)レベルは、自己応答性B細胞数の多いITP患者4例で上昇していた。以上より、制御性B細胞とプレ胚中心B細胞の増加は、BAFFやIFNαによって活性化される自己免疫を反映している可能性があり、未治療ITP患者におけるB細胞サブセットの評価は治療効果を予測する可能性が示唆された。

  • Improved survival of patients with aggressive ATL by increased use of allo-HCT: A prospective observational study.

    Ayumu Ito, Nobuaki Nakano, Takashi Tanaka, Shigeo Fuji, Junya Makiyama, Yoshitaka Inoue, Ilseung Choi, Hirohisa Nakamae, Koji Nagafuji, Ken Takase, Shinichiro Machida, Tsutomu Takahashi, Yasushi Sawayama, Tomohiko Kamimura, Koji Kato, Toshiro Kawakita, Masao Ogata, Rika Sakai, Souichi Shiratori, Kaoru Uchimaru, Yoshihiro Inamoto, Atae Utsunomiya, Takahiro Fukuda

    Blood advances   5 ( 20 )   4156 - 4166   2021.10( ISSN:2473-9529

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    Publishing type:Research paper (scientific journal)   International / domestic magazine:International journal  

    Aggressive adult T-cell leukemia/lymphoma (ATL) is a hematological malignancy that is difficult to treat with chemotherapy alone, and allogeneic hematopoietic cell transplantation (allo-HCT) is a potentially curative therapy. We conducted a multicenter, prospective, observational study to clarify the treatment outcomes of aggressive ATL in the current era. Between 2015 and 2018, 113 patients aged 70 years or younger with newly diagnosed aggressive ATL were enrolled. The median age at diagnosis was 61 years old. Treatment outcomes were compared with those of 1,792 ATL patients diagnosed between 2000 and 2013 in our previous retrospective study. The inclusion criteria were the same in both studies. The prospective cohort demonstrated better overall survival (OS) than the retrospective cohort (2-year OS, 45% versus 29%, respectively; P<0.001), with a much higher proportion of patients receiving allo-HCT (80% versus 34%, respectively; P<0.001) and a shorter interval from diagnosis to allo-HCT (median, 128 versus 170 days, respectively; P<0.001). Among the 90 patients who received allo-HCT (cord blood, n=30; HLA-haploidentical related donors, n=20; other related donors, n=14; other unrelated donors, n=26), the 2-year probabilities of OS, non-relapse mortality (NRM), and disease progression were 44%, 23%, and 46%, respectively. OS and NRM did not differ statistically according to donor type. Our results suggest that increased application of allo-HCT improved the survival of patients with aggressive ATL. The use of cord blood or HLA-haploidentical donors may be feasible for aggressive ATL when HLA-matched related donors are unavailable. This study was registered with the UMIN Clinical Trials Registry (UMIN 000017672).

    DOI: 10.1182/bloodadvances.2021004932

    PubMed

  • Allogeneic hematopoietic stem cell transplantation for myelodysplastic syndrome in adolescent and young adult patients.

    Yoshimitsu Shimomura, Masahiko Hara, Takaaki Konuma, Hidehiro Itonaga, Noriko Doki, Yukiyasu Ozawa, Tetsuya Eto, Naoyuki Uchida, Jun Aoki, Jun Kato, Yasushi Onishi, Satoshi Takahashi, Kentaro Fukushima, Hirohisa Nakamae, Toshiro Kawakita, Junji Tanaka, Takahiro Fukuda, Yoshiko Atsuta, Takayuki Ishikawa, Ken Ishiyama

    Bone marrow transplantation   56 ( 10 )   2510 - 2517   2021.10( ISSN:0268-3369

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    Publishing type:Research paper (scientific journal)   International / domestic magazine:International journal  

    Allogeneic hematopoietic stem cell transplantation (HSCT) is the only curable treatment option for adolescent and young adult (AYA) patients with myelodysplastic syndrome (MDS). The study aim was to evaluate epidemiological data and identify prognostic factors for AYA patients with MDS undergoing allogeneic HSCT. Here, 645 patients were selected from patients enrolled in a multicenter prospective registry for HSCT from 2000 to 2015. The primary endpoint was 3-year overall survival (OS). Survival rates were estimated using the Kaplan-Meier method. Prognostic factors were identified using the multivariable Cox proportional hazards model. The 3-year OS was 71.2% (95% confidence interval [CI]: 67.4-74.6%). In multivariable analysis, active disease status (adjusted hazard ratio: 1.54, 95% CI: 1.09-2.18, p = 0.016), poor cytogenetic risk (1.62, 1.12-2.36, p = 0.011), poor performance status (2.01, 1.13-3.56, p = 0.016), human leukocyte antigen (HLA)-matched unrelated donors (2.23, 1.39-3.59, p < 0.001), HLA-mismatched unrelated donors (2.16, 1.09-4.28, p = 0.027), and cord blood transplantation (2.44, 1.43-4.17, p = 0.001) were significantly associated with poor 3-year OS. In conclusion, in AYA patients with MDS the 3-year OS following allogeneic HSCT was 71.2%. Active disease status, poor cytogenetic risk, poor performance status, and donor sources other than related donors were associated with poor 3-year OS.

    DOI: 10.1038/s41409-021-01324-8

    PubMed

  • Tiny transformed diffuse large B cell lymphoma localized to the left conjunctiva.

    Naonori Harada, Mizuki Tagami, Hideo Koh, Masahiko Ohsawa, Masayuki Hino, Hirohisa Nakamae

    International journal of hematology   114 ( 4 )   413 - 414   2021.10( ISSN:0925-5710

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    International / domestic magazine:Domestic journal  

    DOI: 10.1007/s12185-021-03208-5

    PubMed

  • Kinetics of IgG subclasses and their effects on the incidence of infection after allogeneic hematopoietic stem cell transplantation.

    Koh S, Koh H, Nanno S, Okamura H, Nakashima Y, Nakamae M, Hirose A, Hino M, Nakamae H

    Transplant immunology   67   101413   2021.08( ISSN:0966-3274

  • Residual disease is a strong prognostic marker in patients with acute lymphoblastic leukaemia with chemotherapy-refractory or relapsed disease prior to allogeneic stem cell transplantation.

    Momoko Nakamura, Yasuyuki Arai, Shigeki Hirabayashi, Tadakazu Kondo, Noriko Doki, Naoyuki Uchida, Takahiro Fukuda, Yukiyasu Ozawa, Masatsugu Tanaka, Masashi Sawa, Yuta Katayama, Yoshinobu Kanda, Souichi Shiratori, Hirohisa Nakamae, Satoshi Yoshioka, Makoto Onizuka, Tatsuo Ichinohe, Yoshiko Atsuta, Shinichi Kako

    British journal of haematology   194 ( 2 )   403 - 413   2021.07( ISSN:0007-1048

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    Publishing type:Research paper (scientific journal)   International / domestic magazine:International journal  

    Allogeneic haematopoietic stem cell transplantation (allo-HSCT) is one of the curative treatment options for acute lymphoblastic leukaemia (ALL). However, the outcomes in patients transplanted without complete remission (non-CR) have not yet been fully reported, and detailed analyses are required to identify subgroups in which optimal prognosis is expected and to optimize pre-transplant therapeutic strategies. Hence, we performed a multicentred retrospective cohort study including a total of 663 adult ALL patients transplanted at non-CR status; the median bone marrow (BM) blast counts at HSCT was 13·2%, and 203 patients (30·6%) were treated at primary induction failure status. The overall survival (OS) was 31·1% at two years, and the multivariate analyses identified five prognostic risk factors, including older age (≥50 years), increased BM blasts (≥10%), poor performance status, high haematopoietic cell transplantation (HCT)-comorbidity index, and relapsed disease status, among which BM blast was the most significantly related. A predictive scoring system composed of these risk factors clearly stratified OS (15·6-59·5% at two years). In conclusion, this is the first large-scale study to analyze the correlation of patient characteristics with post-transplant prognosis in ALL transplanted at non-CR status. The importance of blast control before HSCT should be focused on for better patient prognosis.

    DOI: 10.1111/bjh.17646

    PubMed

  • 多発性骨髄腫患者における活性化インテグリンβ7の発現(Expression of activated integrin β7 in multiple myeloma patients)

    Hosen Naoki, Yoshihara Satoshi, Takamatsu Hiroyuki, Ri Masaki, Nagata Yasuyuki, Kosugi Hiroshi, Shimomura Yoshimitsu, Hanamura Ichiro, Fuji Shigeo, Minauchi Koichiro, Kuroda Junya, Suzuki Rikio, Nishimura Noriko, Uoshima Nobuhiko, Nakamae Hirohisa, Kawano Yawara, Mizuno Ishikazu, Gomyo Hiroshi, Suzuki Kenshi, Ozaki Shuji, Nakamura Shingen, Imai Yoichi, Kizaki Masahiro, Negoro Eiju, Handa Hiroshi, Iida Shinsuke

    International Journal of Hematology   114 ( 1 )   3 - 7   2021.07( ISSN:0925-5710

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    インテグリンβ7の活性化立体構造を認識するモノクローナル抗体(クローンMMG49)を用いて、様々なタイプの多発性骨髄腫(MM)患者における活性化インテグリンβ7の発現を検討した。症候性MM患者137例の骨髄中のCD38++CD138+MM形質細胞における活性化インテグリンβ7の発現をフローサイトメトリーで解析した。MM形質細胞の80%以上がMMG49陽性であったサンプルをMMG49陽性と定義したところ、MM患者137例のうち60例(44%)がMMG49陽性であった。臨床パラメータとMMG49陽性度には相関関係はなかった。活性化インテグリンβ7は、重度の治療を受けた患者でも、殆どのMM細胞で高発現していた。ダラツムマブの投与は、活性化インテグリンβ7の発現に影響を与えなかった。また、活性化インテグリンβ7の発現は、いかなる遺伝子異常とも相関していなかった。活性化インテグリンβ7は、MMの形質細胞だけでなく、MM患者の骨髄に存在する多くのCD38low/-CD138-CD19+B細胞にも高発現していた。以上より、MMG49を活用したCAR T細胞療法は、再発または難治性のMM患者に恩恵をもたらす可能性があると考えられた。

  • Acute fibrinous and organizing pneumonia following hemophagocytic syndrome in two adult patients with hematological malignancies

    Nanno Satoru, Koh Hideo, Okamura Hiroshi, Nishimoto Mitsutaka, Nakashima Yasuhiro, Ohsawa Masahiko, Hino Masayuki, Nakamae Hirohisa

    Journal of Clinical and Experimental Hematopathology   61 ( 2 )   93 - 96   2021.06( ISSN:1346-4280

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    <p>Acute fibrinous and organizing pneumonia (AFOP) is a rare acute lung injury featuring pathological intra-alveolar fibrin balls and organizing pneumonia without hyaline membranes or eosinophils. AFOP forms acute and subacute patterns; the former often has a poor prognosis, whereas the latter has better survival. Secondary hemophagocytic syndrome (HPS) is a cytokine-related and potentially lethal disorder induced by various diseases, and pulmonary involvement in HPS is not rare. However, to our knowledge, no report has addressed the association between secondary HPS and AFOP development. We report two cases of subacute AFOP following HPS in hematological malignancies.</p>

    DOI: 10.3960/jslrt.20042

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  • 成人血液悪性腫瘍患者2例に発症した血球貪食症候群に続く急性線維素性器質化肺炎(Acute fibrinous and organizing pneumonia following hemophagocytic syndrome in two adult patients with hematological malignancies)

    Nanno Satoru, Koh Hideo, Okamura Hiroshi, Nishimoto Mitsutaka, Nakashima Yasuhiro, Ohsawa Masahiko, Hino Masayuki, Nakamae Hirohisa

    Journal of Clinical and Experimental Hematopathology   61 ( 2 )   93 - 96   2021.06( ISSN:1346-4280

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    症例1は63歳男性で、トリソミー8に起因する骨髄異形成症候群であった。その1年半後、輸血依存症となり、低用量プレドニゾロン(PSL)とメテノロンの投与を開始した。その4ヵ月後に汎血球減少、脾腫、高フェリチン血症を呈した。骨髄は低形成で、芽球が22.4%、血球が5.2%であった。また、染色体分析により、5q欠失とトリソミー8を含む複雑な核型が認められた。血球貪食症候群(HPS)と診断した。さらに、右中葉への浸潤と両肺への多発性微小結節が確認された。アムホテリシンBリポソーム製剤(LAMB)とメロペネムの投与では症状は改善しなかった。経気管支肺生検により、急性線維素性器質化肺炎(AFOP)と診断した。メチルプレドニゾロンのパルス療法を行い、その後PSLの維持療法を行った。浸潤性陰影はすぐに消失したが、微小結節は大きくなっていった。その後、ボリコナゾール投与により、病変は徐々に小さくなり消失した。症例2は38歳女性で、縦隔原発B細胞リンパ腫であった。リンパ腫に対する各種薬物療法と放射線照射により、初回の完全奏効が得られた。その1ヵ月後に再発し、2回目のサルベージ化学療法の1クール目で部分奏効が達成された。しかし、発熱性好中球減少症を発症し、左肺にすりガラス様陰影(GGO)を伴う浸潤影が認められた。イミペネム+シラスタチンとカスポファンギンをタゾバクタム+ピペラシリンとLAMBに変更した。発熱を伴う重度の汎血球減少が残ったため、骨髄穿刺を行った結果、血球貪食細胞を含む著しい骨髄低形成が認められた。染色体の核型は正常であった。HPSと診断した。その後、GGOを伴う浸潤影が拡大し、左肺に新たなGGOが発生した。経気管支生検により、AFOPと診断した。PSL投与により、浸潤影は徐々に消失した。

  • 成人急性骨髄性白血病に対する単一ユニット臍帯血移植後の移植片対宿主病予防におけるメトトレキサート投与量の影響(Effect of methotrexate dose in graft-versus-host disease prophylaxis after single-unit cord blood transplantation in adult acute myeloid leukemia)

    Terakura Seitaro, Kuwatsuka Yachiyo, Sugita Junichi, Takahashi Satoshi, Ozawa Yukiyasu, Ozeki Kazutaka, Yoshioka Satoshi, Nakamae Hirohisa, Kawakita Toshiro, Sawa Masashi, Morishige Satoshi, Najima Yuho, Katsuoka Yuna, Sakaida Emiko, Kouzai Yasuji, Kimura Takafumi, Ichinohe Tatsuo, Fukuda Takahiro, Atsuta Yoshiko, Murata Makoto, Teshima Takanori

    International Journal of Hematology   113 ( 6 )   840 - 850   2021.06( ISSN:0925-5710

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    臍帯血移植後の移植片対宿主病(GVHD)を予防するためのカルシニューリン阻害剤(CNI)にメトトレキサート(MTX)またはミコフェノール酸モフェチル(MMF)を加えたレジメンとMTXの最適な投与量を検討した。臍帯血単一ユニットの移植を受けた患者888例を対象とした。移植後1日目、3日目、6日目に、415例(男性222例、女性193例、年齢中央値41歳)に対してMTXをそれぞれ15mg/m2、10mg/m2、10mg/m2(MTX15-10-10)、294例(男性144例、女性150例、年齢中央値40歳)にMTX10-7-7、71例(男性42例、女性29例、年齢中央値40歳)にMTX5-5-5、108例(男性56例、女性52例、年齢中央値43歳)にMMFを投与した。CNIはシクロスポリン(CyA)とタクロリムス(Tac)を用いた。MTX15-10-10を基準とした多変量解析では、MTX15-10-10群と比較して、MTX10-7-7群では好中球と血小板の生着の尤度は有意に悪かったが、MMF群ではMTX15-10-10群と同様に良好であった。多変量モデルでは、CyA群対Tac群およびMTXとMMFの4群間に関する全ての変数が、グレードII-IVの急性GVHDのリスクに対して有意になった。Tac群では、MTXの組み合わせによる有意な追加効果が観察され、その効果は低用量のMTXやMMFで大きかった。加えて、GVHD予防レジメンの間の生存リスクには有意な差はなかった。以上より、GVHD予防としてCyA+MTX15-10-10またはTac+MMFの併用が推奨された。

  • リンパ管造影により乳び胸水が著明に改善したびまん性大細胞型B細胞リンパ腫

    森口 慎, 高桑 輝人, 影山 健, 岡村 浩史, 南野 智, 西本 光孝, 中嶋 康博, 康 秀男, 中根 孝彦, 山本 晃, 中前 博久, 日野 雅之

    臨床血液   62 ( 6 )   554 - 559   2021.06( ISSN:0485-1439

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    乳び胸水はびまん性大細胞型B細胞リンパ腫(DLBCL)の症例にまれに認められる臨床徴候であるが,管理に難渋する場合が多く予後不良である。症例は59歳の女性で,DLBCLの診断時に右胸水貯留を認めた。化学療法に反応してリンパ腫病変は縮小したが胸水の増悪を認めた。胸水穿刺にて乳び胸水と診断し,絶食・中心静脈栄養管理を行うも効果は不良であった。乳び胸水の原因精査のため超音波ガイド下で鼠径リンパ節穿刺によるリンパ管造影検査を行った。乳びの漏出部位は特定できなかったが,検査翌日に胸水の著明な改善を認め,2ヵ月で胸水は完全に消失した。リンパ管造影検査は低侵襲で合併症が少ない検査であり,乳びの漏出部位の特定だけではなく乳び胸水の改善・消失にも寄与する可能性があるため,化学療法や栄養管理に反応しない難治性乳び胸水に対し検討すべき検査と考えられる。(著者抄録)

  • Successful management of therapy-related chronic myelomonocytic leukemia with cytarabine, aclarubicin, and azacitidine following tegafur/gimeracil/oteracil.

    Nakako S, Takakuwa T, Ichimura H, Okamura H, Nanno S, Nishimoto M, Nakashima Y, Koh H, Hino M, Nakamae H

    Clinical case reports   9 ( 6 )   e04298   2021.06

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  • Risk Factor and Long-Term Outcome Analyses for Acute Limbic Encephalitis and Calcineurin Inhibitor-Induced Encephalopathy in Adults following Allogeneic Hematopoietic Cell Transplantation.

    Tanizawa N, Koh H, Okamura H, Yamamoto K, Makuuchi Y, Kuno M, Takakuwa T, Koh S, Nanno S, Nishimoto M, Hirose A, Nakamae M, Nakashima Y, Nakane T, Hino M, Nakamae H

    Transplantation and cellular therapy   27 ( 5 )   437.e1 - 437.e9   2021.05( ISSN:2666-6375

  • Recurrence of Acute Lymphoblastic Leukemia with Bone Marrow Necrosis: A Case Report and Review of the Literature on the MRI Features of Bone Marrow Necrosis. Reviewed

    Harada N, Nishimoto M, Ikemoto A, Okamura H, Koh S, Nanno S, Nakashima Y, Koh H, Nakane T, Kuwae Y, Ohsawa M, Hino M, Nakamae H

    一般社団法人 日本内科学会 Internal medicine (Tokyo, Japan)   60 ( 7 )   1083 - 1088   2021.04( ISSN:0918-2918

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    <p>Bone marrow necrosis (BMN) is a rare but important complication of hematological malignancies. We report the case of a 52-year-old male patient with a recurrence of acute lymphoblastic leukemia (ALL) accompanied by BMN. After re-induction therapy, bone marrow aspiration (BMA) and biopsy from the iliac bone showed necrotic cells and eosinophilic debris, respectively. Magnetic resonance imaging (MRI) showed heterogeneous signals in the bilateral iliac bone, possibly reflecting various stages of BMN. BMA from the sternum eventually revealed the recurrence of ALL after a few weeks. Comprehensive assessments, including MRI and repeated bone marrow tests, are required when evaluating the underlying hematological malignancies of patients with BMN. </p>

    DOI: 10.2169/internalmedicine.5815-20

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  • Single Cord Blood Transplantation Versus Unmanipulated Haploidentical Transplantation for Adults with Acute Myeloid Leukemia in Complete Remission. Reviewed

    Konuma T, Kanda J, Yamasaki S, Harada K, Shimomura Y, Terakura S, Mizuno S, Uchida N, Tanaka M, Doki N, Ozawa Y, Nakamae H, Sawa M, Matsuoka KI, Morishige S, Maruyama Y, Ikegame K, Kimura T, Kanda Y, Ichinohe T, Atsuta Y, Yanada M

    Transplantation and cellular therapy   27 ( 4 )   334.e1 - 334.e11   2021.04( ISSN:2666-6375

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    DOI: 10.1016/j.jtct.2021.01.023

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  • High-grade B-cell lymphoma developed during the treatment of chronic myeloid leukemia with bosutinib.

    Takakuwa T, Sakai R, Koh S, Okamura H, Nanno S, Nakashima Y, Nakane T, Koh H, Hino M, Nakamae H

    Clinical case reports   9 ( 3 )   1344 - 1349   2021.03

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  • Effect of methotrexate dose in graft-versus-host disease prophylaxis after single-unit cord blood transplantation in adult acute myeloid leukemia Reviewed

    Terakura Seitaro, Kuwatsuka Yachiyo, Sugita Junichi, Takahashi Satoshi, Ozawa Yukiyasu, Ozeki Kazutaka, Yoshioka Satoshi, Nakamae Hirohisa, Kawakita Toshiro, Sawa Masashi, Morishige Satoshi, Najima Yuho, Katsuoka Yuna, Sakaida Emiko, Kouzai Yasuji, Kimura Takafumi, Ichinohe Tatsuo, Fukuda Takahiro, Atsuta Yoshiko, Murata Makoto, Teshima Takanori

    INTERNATIONAL JOURNAL OF HEMATOLOGY   2021.02( ISSN:0925-5710

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s12185-021-03097-8

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  • Pretransplant plasma brain natriuretic peptide and N-terminal probrain natriuretic peptide are more useful prognostic markers of overall survival after allogeneic hematopoietic cell transplantation than echocardiography Reviewed

    Harada Naonori, Okamura Hiroshi, Nakane Takahiko, Koh Shiro, Nanno Satoru, Nishimoto Mitsutaka, Hirose Asao, Nakamae Mika, Nakashima Yasuhiro, Koh Hideo, Hino Masayuki, Nakamae Hirohisa

    BONE MARROW TRANSPLANTATION   2021.02( ISSN:0268-3369

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    DOI: 10.1038/s41409-021-01224-x

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  • Chromosomal defects and survival in patients with adult T-cell leukemia/lymphoma after allogeneic HSCT Reviewed

    Nakano Nobuaki, Utsunomiya Atae, Matsuo Keitaro, Yoshida Noriaki, Seto Masao, Ohshima Kouichi, Fujiwara Hiroshi, Fuji Shigeo, Takatsuka Yoshifusa, Ito Ayumu, Miyamoto Toshihiro, Suehiro Youko, Nakamae Hirohisa, Sawayama Yasushi, Yuasa Mitsuhiro, Miyazaki Yasuhiko, Ota Shuichi, Imada Kazunori, Fukuda Takahiro, Ichinohe Tatsuo, Atsuta Yoshiko, Kato Koji

    BLOOD ADVANCES   5 ( 2 )   475 - 486   2021.01( ISSN:2473-9529

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    DOI: 10.1182/bloodadvances.2020003639

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  • Severe cryoglobulinemia with cerebral infarction successfully treated with steroid and rituximab: A case report Reviewed

    Yagi Naoko, Yoshimura Takuro, Nakamae Hirohisa, Hayashi Daisuke, Tanaka Yasuyuki, Ichikawa Yoshitaka, Hino Masayuki

    CLINICAL CASE REPORTS   9 ( 1 )   543 - 546   2021.01( ISSN:2050-0904

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    DOI: 10.1002/ccr3.3578

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  • Isatuximab plus Pomalidomide and Dexamethasone in a Patient with Dialysis-Dependent Multiple Myeloma.

    Takakuwa T, Ohta K, Sogabe N, Nishimoto M, Kuno M, Makuuchi Y, Okamura H, Nakashima Y, Koh H, Nakamae H, Hino M

    Chemotherapy   66 ( 5-6 )   192 - 195   2021( ISSN:0009-3157

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  • Early Elevation of Complement Factor Ba Is a Predictive Biomarker for Transplant-Associated Thrombotic Microangiopathy.

    Hiroshi Okamura, Hirohisa Nakamae, Takero Shindo, Katsuki Ohtani, Yoshihiko Hidaka, Yasufumi Ohtsuka, Yosuke Makuuchi, Masatomo Kuno, Teruhito Takakuwa, Naonori Harada, Mitsutaka Nishimoto, Yasuhiro Nakashima, Hideo Koh, Asao Hirose, Mika Nakamae, Nobutaka Wakamiya, Masayuki Hino, Norimitsu Inoue

    Frontiers in immunology   12   695037 - 695037   2021

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    Publishing type:Research paper (scientific journal)   International / domestic magazine:International journal  

    Transplant-associated thrombotic microangiopathy (TA-TMA) is a fatal complication after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Previous reports suggest that TA-TMA is caused by complement activation by complement-related genetic variants; however, this needs to be verified, especially in adults. Here, we performed a nested case-control study of allo-HSCT-treated adults at a single center. Fifteen TA-TMA patients and 15 non-TA-TMA patients, matched according to the propensity score, were enrolled. Based on a previous report showing an association between complement-related genes and development of TA-TMA, we first sequenced these 17 genes. Both cohorts harbored several genetic variants with rare allele frequencies; however, there was no difference in the percentage of patients in the TA-TMA and non-TA-TMA groups with the rare variants, or in the average number of rare variants per patient. Second, we measured plasma concentrations of complement proteins. Notably, levels of Ba protein on Day 7 following allo-HSCT were abnormally and significantly higher in TA-TMA than in non-TA-TMA cases, suggesting that complement activation via the alternative pathway contributes to TA-TMA. All other parameters, including soluble C5b-9, on Day 7 were similar between the groups. The levels of C3, C4, CH50, and complement factors H and I in the TA-TMA group after Day 28 were significantly lower than those in the non-TA-TMA group. Complement-related genetic variants did not predict TA-TMA development. By contrast, abnormally high levels of Ba on Day 7 did predict development of TA-TMA and non-relapse mortality. Thus, Ba levels on Day 7 after allo-HSCT are a sensitive and prognostic biomarker of TA-TMA.

    DOI: 10.3389/fimmu.2021.695037

    PubMed

  • Diffuse large B-cell lymphoma with markedly improved chylothorax by lymphangiography

    MORIGUCHI Makoto, TAKAKUWA Teruhito, KAGEYAMA Ken, OKAMURA Hiroshi, NANNO Satoru, NISHIMOTO Mitsutaka, NAKASHIMA Yasuhiro, KOH Hideo, NAKANE Takahiko, YAMAMOTO Akira, NAKAMAE Hirohisa, HINO Masayuki

    Rinsho Ketsueki   62 ( 6 )   554 - 559   2021( ISSN:0485-1439

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    <p>Chylothorax is a rare clinical sign in patients with diffuse large B-cell lymphoma (DLBCL), which is often challenging to manage and has a poor prognosis. We report the case of a 59-year-old woman who presented with right pleural effusion at the time of DLBCL diagnosis. Lymphadenopathy rapidly improved in response to chemotherapy. However, the pleural effusion progressed and was identified as chylothorax by thoracentesis. Because attempts to manage the condition with fasting and central venous nutrition were unsuccessful, we performed ultrasound-guided intranodal lipiodol lymphangiography from the inguinal lymph node. Although leak sites were not detected, the pleural effusion markedly improved on the day after the examination and resolved after 2 months. Lymphangiography is a minimally invasive examination with few complications. It contributes not only to the identification of leak sites but also to the improvement and resolution of chylothorax. Therefore, lymphangiography should be considered for refractory chylothorax that is unresponsive to chemotherapy or nutritional management.</p>

    DOI: 10.11406/rinketsu.62.554

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  • Relapse of acute myeloid leukemia after allogeneic hematopoietic cell transplantation: clinical features and outcomes Reviewed

    Yanada Masamitsu, Konuma Takaaki, Yamasaki Satoshi, Kondo Tadakazu, Fukuda Takahiro, Shingai Naoki, Sawa Masashi, Ozawa Yukiyasu, Tanaka Masatsugu, Uchida Naoyuki, Nakamae Hirohisa, Katayama Yuta, Matsuoka Ken-ichi, Kimura Takafumi, Kanda Yoshinobu, Ichinohe Tatsuo, Atsuta Yoshiko, Yano Shingo

    BONE MARROW TRANSPLANTATION   2020.12( ISSN:0268-3369

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    DOI: 10.1038/s41409-020-01163-z

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  • Acquired Gray Platelet Syndrome Associated with Primary Myelofibrosis. Reviewed

    Ido K, Nakane T, Tanizawa N, Makuuchi Y, Okamura H, Koh S, Nanno S, Nishimoto M, Hirose A, Nakamae M, Nakashima Y, Koh H, Hino M, Nakamae H

    Internal medicine (Tokyo, Japan)   59 ( 21 )   2751 - 2756   2020.11( ISSN:0918-2918

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.2169/internalmedicine.4912-20

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  • Acquired Gray Platelet Syndrome Associated with Primary Myelofibrosis(和訳中) Reviewed

    Ido Kentaro, Nakane Takahiko, Tanizawa Nao, Makuuchi Yosuke, Okamura Hiroshi, Koh Shiro, Nanno Satoru, Nishimoto Mitsutaka, Hirose Asao, Nakamae Mika, Nakashima Yasuhiro, Koh Hideo, Hino Masayuki, Nakamae Hirohisa

    (一社)日本内科学会 Internal Medicine   59 ( 21 )   2751 - 2756   2020.11( ISSN:0918-2918

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  • Clinical usefulness of very high serum soluble interleukin-2 receptor levels for the detection of tuberculous peritonitis in a patient with chronic myelogenous leukemia Reviewed

    Moriguchi Makoto, Koh Hideo, Hayashi Tetsuya, Okamura Hiroshi, Nanno Satoru, Nakashima Yasuhiro, Nakane Takahiko, Imoto Waki, Yamada Koichi, Kakeya Hiroshi, Hino Masayuki, Nakamae Hirohisa

    JOURNAL OF INFECTION AND CHEMOTHERAPY   26 ( 10 )   1054 - 1057   2020.10( ISSN:1341-321X

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    DOI: 10.1016/j.jiac.2020.05.001

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  • 同種造血幹細胞移植後にみられた赤血球増加症 Reviewed

    川原 宏惠, 高桑 輝人, 中前 美佳, 久保田 浩, 岡村 浩史, 南野 智, 中嶋 康博, 中根 孝彦, 康 秀男, 廣瀬 朝生, 日野 雅之, 中前 博久

    (一社)日本血液学会-東京事務局 臨床血液   61 ( 10 )   1492 - 1496   2020.10( ISSN:0485-1439

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    移植後赤血球増加症(PTE)が同種造血幹細胞移植後に生じることは稀であり,臨床的特徴は不明な部分が多い。当院で1992年1月〜2011年12月の間に同種造血幹細胞移植を行った321例のうち3例のPTE患者の臨床的特徴について検討を行った。3例はいずれもヘモグロビン最大時の白血球数および血小板数は正常範囲内であった。エリスロポエチンは2例で測定され,ともに正常範囲内であった。3例ともに細胞減少療法や抗血小板薬投与は行わずに血栓症や出血のイベントはなかった。3例はいずれもJAK2V617F変異陰性であったが,2例はJAK/STAT経路の上流シグナルであるIL-13が高値を示した。真性多血症ではJAK2遺伝子の変異が病態に大きく寄与していることが知られているが,PTEでは病態が異なる可能性がある。今後の症例集積により同種移植後PTEの適切なマネジメントを構築する必要があると考える。(著者抄録)

  • Long-term results of reduced-intensity conditioning allogeneic hematopoietic cell transplantation for older patients with acute myeloid leukemia: a retrospective analysis of 10-year follow-up data Reviewed

    Yanada Masamitsu, Fukuda Takahiro, Tanaka Masatsugu, Ota Shuichi, Toya Takashi, Mori Takehiko, Uchida Naoyuki, Ozawa Yukiyasu, Nakamae Hirohisa, Kanda Yoshinobu, Ichinohe Tatsuo, Atsuta Yoshiko, Yano Shingo

    BONE MARROW TRANSPLANTATION   55 ( 10 )   2008 - 2016   2020.10( ISSN:0268-3369

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41409-020-0868-7

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  • Clinical usefulness of very high serum soluble interleukin-2 receptor levels for the detection of tuberculous peritonitis in a patient with chronic myelogenous leukemia(和訳中) Reviewed

    Moriguchi Makoto, Koh Hideo, Hayashi Tetsuya, Okamura Hiroshi, Nanno Satoru, Nakashima Yasuhiro, Nakane Takahiko, Imoto Waki, Yamada Koichi, Kakeya Hiroshi, Hino Masayuki, Nakamae Hirohisa

    エルゼビア・ジャパン(株) Journal of Infection and Chemotherapy   26 ( 10 )   1054 - 1057   2020.10( ISSN:1341-321X

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  • The critical role of CD4(+) T cells in PD-1 blockade against MHC-II-expressing tumors such as classic Hodgkin lymphoma Reviewed

    Nagasaki Joji, Togashi Yosuke, Sugawara Takeaki, Itami Makiko, Yamauchi Nobuhiko, Yuda Junichiro, Sugano Masato, Ohara Yuuki, Minami Yosuke, Nakamae Hirohisa, Hino Masayuki, Takeuchi Masahiro, Nishikawa Hiroyoshi

    BLOOD ADVANCES   4 ( 17 )   4069 - 4082   2020.09( ISSN:2473-9529

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    DOI: 10.1182/bloodadvances.2020002098

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  • Predicting non-relapse mortality following allogeneic hematopoietic cell transplantation during first remission of acute myeloid leukemia Reviewed

    Yanada Masamitsu, Konuma Takaaki, Mizuno Shohei, Saburi Masuho, Shinohara Akihito, Tanaka Masatsugu, Marumo Atsushi, Sawa Masashi, Uchida Naoyuki, Ozawa Yukiyasu, Onizuka Makoto, Yoshioka Satoshi, Nakamae Hirohisa, Kondo Tadakazu, Kimura Takafumi, Kanda Junya, Fukuda Takahiro, Atsuta Yoshiko, Nakasone Hideki, Yano Shingo

    BONE MARROW TRANSPLANTATION   2020.08( ISSN:0268-3369

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    DOI: 10.1038/s41409-020-01032-9

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  • Effect of Prophylactic Post-transplant Ponatinib Administration on Outcomes in Patients With Philadelphia Chromosome-positive Acute Lymphoblastic Leukemia. Reviewed

    Nanno S, Matsumoto K, Nakamae M, Okamura H, Nishimoto M, Hirose A, Koh H, Nakashima Y, Nakane T, Morita K, Hino M, Nakamae H

    Clinical lymphoma, myeloma & leukemia   2020.07( ISSN:2152-2650

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    DOI: 10.1016/j.clml.2020.07.005

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  • Successful treatment with baloxavir marboxil of a patient with peramivir-resistant influenza A/H3N2 with a dual E119D/R292K substitution after allogeneic hematopoietic cell transplantation: a case report Reviewed

    Harada Naonori, Shibata Wataru, Koh Hideo, Takashita Emi, Fujisaki Seiichiro, Okamura Hiroshi, Nanno Satoru, Yamada Koichi, Nakamae Hirohisa, Hino Masayuki, Kakeya Hiroshi

    BMC INFECTIOUS DISEASES   20 ( 1 )   478   2020.07

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    DOI: 10.1186/s12879-020-05205-1

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  • Interactive web application for plotting personalized prognosis prediction curves in allogeneic hematopoietic cell transplantation using machine learning. Reviewed

    Okamura H, Nakamae M, Koh S, Nanno S, Nakashima Y, Koh H, Nakane T, Hirose A, Hino M, Nakamae H

    Transplantation   2020.06( ISSN:0041-1337

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    DOI: 10.1097/TP.0000000000003357

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  • Treatment-free remission after first-line dasatinib discontinuation in patients with chronic myeloid leukaemia (first-line DADI trial): a single-arm, multicentre, phase 2 trial Reviewed

    Kimura Shinya, Imagawa Jun, Murai Kazunori, Hino Masayuki, Kitawaki Toshio, Okada Masaya, Tanaka Hideo, Shindo Motohiro, Kumagai Takashi, Ikezoe Takayuki, Uoshima Nobuhiko, Sato Tsutomu, Watanabe Reiko, Kowata Shugo, Hayakawa Masaya, Hosoki Takaaki, Ikeda Kazuhiko, Kobayashi Tsutomu, Kakinoki Yasutaka, Nishimoto Tetsuo, Takezako Naoki, Shibayama Hirohiko, Takaori-Kondo Akifumi, Nakamae Hirohisa, Kawaguchi Atsushi, Ureshino Hiroshi, Sakamoto Junichi, Ishida Yoji

    LANCET HAEMATOLOGY   7 ( 3 )   E218 - E225   2020.03( ISSN:2352-3026

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    DOI: 10.1016/S2352-3026(19)30235-2

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  • 同種造血細胞移植後難治性ウイルス血症・感染症に対する高用量polyclonal intravenous immunoglobulin

    井戸 健太郎, 中根 孝彦, 岡村 浩史, 南野 智, 西本 光孝, 廣瀬 朝生, 中前 美佳, 中嶋 康博, 康 秀男, 日野 雅之, 中前 博久

    臨床血液   61 ( 3 )   215 - 222   2020.03( ISSN:0485-1439

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    我々は致死的合併症の一つである同種造血細胞移植後難治性ウイルス血症・感染症に対するpolyclonal intravenous immunoglobulin(polyclonal IVIG)400mg/kg/日連続5日間投与の有効性・安全性を評価するためにこの前向きパイロット試験を計画した。14例の試験参加者は全例介入を受けた。Human parvovirus B19血症あるいは高リスクrespiratory syncytial virus肺炎/気管支炎といった外因性ウイルス血症・感染症に対して投与された3例は全例complete responseに到達した。1例でIVIG開始後2日に心不全が観察された。結論として,本研究は高用量polyclonal IVIGが同種造血細胞移植後のとくに,難治性外因性ウイルス感染症に対して有効である可能性を示唆している。(著者抄録)

  • A high CD34(+) cell dose is associated with better disease-free survival in patients with low-risk diseases undergoing peripheral blood stem cell transplantation from HLA-matched related donors Reviewed

    Yokoyama Yasuhisa, Maie Koichiro, Fukuda Takahiro, Uchida Naoyuki, Mukae Junichi, Sawa Masashi, Kubo Kohmei, Kurokawa Mineo, Nakamae Hirohisa, Ichinohe Tatsuo, Atsuta Yoshiko, Chiba Shigeru

    BONE MARROW TRANSPLANTATION   2020.02( ISSN:0268-3369

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    DOI: 10.1038/s41409-020-0817-5

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  • 経気管支肺胞生検で診断できた肺浸潤を伴う急性単球性白血病 Reviewed

    原田 尚憲, 中根 孝彦, 岡村 浩史, 南野 智, 中嶋 康博, 康 秀男, 田中 さやか, 大澤 政彦, 日野 雅之, 中前 博久

    (一社)日本血液学会-東京事務局 臨床血液   61 ( 1 )   27 - 32   2020.01( ISSN:0485-1439

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  • Clinical Characteristics of Rapidly Progressive Fatal Hemorrhagic Pneumonia Caused by Stenotrophomonas maltophilia(和訳中) Reviewed

    Imoto Waki, Yamada Koichi, Yamairi Kazushi, Shibata Wataru, Namikawa Hiroki, Yukawa Satomi, Yoshii Naoko, Nakaie Kiyotaka, Hirose Asao, Koh Hideo, Watanabe Tetsuya, Asai Kazuhisa, Nakamae Hirohisa, Kaneko Yukihiro, Kawaguchi Tomoya, Hino Masayuki, Kakeya Hiroshi

    (一社)日本内科学会 Internal Medicine   59 ( 2 )   193 - 198   2020.01( ISSN:0918-2918

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  • Pulmonary infiltration of acute monoblastic leukemia diagnosed by transbronchial lung biopsy Reviewed

    HARADA Naonori, NAKAMAE Hirohisa, NAKANE Takahiko, OKAMURA Hiroshi, NANNO Satoru, NAKASHIMA Yasuhiro, KOH Hideo, TANAKA Sayaka, OHSAWA Masahiko, HINO Masayuki

    The Japanese Society of Hematology, Rinsho Ketsueki   61 ( 1 )   27 - 32   2020( ISSN:0485-1439

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    <p>A 65-year-old woman was urgently admitted to our hospital for antibiotic-resistant fever, hypoxemia, and hyperleukocytosis and was diagnosed with acute monoblastic leukemia. Chest computed tomography revealed interlobular septal thickening, central ground-glass opacity, and a nodular shadow in the left lower lobe. Although several treatments for infectious disease and acute heart failure were administered, they were less effective. Transbronchial lung biopsy was performed on day 7 of hospitalization, and subsequently, pulmonary leukemic infiltration was confirmed. Based on the diagnosis, we decided to start intensive chemotherapy. Consequently, the abnormal lung shadow on computed tomography vanished, and complete hematological remission was achieved. Although acute myeloid leukemia is frequently associated with lung infiltration during onset, it is often difficult to distinguish it from other pulmonary complications. In clinical practice, intensive chemotherapy is often initiated based on the clinical evaluation without pathological confirmation of the lung disease. Our patient was accurately diagnosed based on the pulmonary leukemic infiltration observed pathologically and recovered well. Here we report our case along with a discussion of the relevant literature.</p>

    DOI: 10.11406/rinketsu.61.27

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    CiNii Article

  • Erythrocytosis following allogeneic hematopoietic stem cell transplantation Reviewed

    KAWAHARA Hiroe, HIROSE Asao, HINO Masayuki, NAKAMAE Hirohisa, TAKAKUWA Teruhito, NAKAMAE Mika, KUBOTA Hiroshi, OKAMURA Hiroshi, NANNO Satoru, NAKASHIMA Yasuhiro, NAKANE Takahiko, KOH Hideo

    The Japanese Society of Hematology, Rinsho Ketsueki   61 ( 10 )   1492 - 1496   2020( ISSN:0485-1439

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    <p>Post-transplant erythrocytosis (PTE) following allogeneic hematopoietic stem cell transplantation (alloHSCT) is rare, and the clinical characteristics of this condition remain unknown. In this study, we examined the clinical characteristics of three PTE cases among 321 patients who received allo HSCT from January 1992 to December 2011 at our institution. All three patients exhibited normal levels of white blood cell and platelet counts when their hemoglobin levels reached their peak. Two patients exhibited normal levels of erythropoietin. No thrombosis or hemorrhage was observed in any of the three patients without cytoreductive therapy or an antiplatelet agent. All three patients tested negative for JAK2V617F mutations. Two patients had high levels of IL-13, an upstream signal for the JAK/STAT pathway. JAK2 is known to significantly contribute to the pathology of polycythemia vera; however, this pathology may differ from that of PTE. We believe that it is necessary to construct a more appropriate management structure for PTE by analyzing more case data in the future.</p>

    DOI: 10.11406/rinketsu.61.1492

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  • [High-dose polyclonal intravenous immunoglobulin therapy for refractory viral infections including viremia after allogeneic hematopoietic cell transplantation]. Reviewed

    Ido K, Nakane T, Okamura H, Nanno S, Nishimoto M, Hirose A, Nakamae M, Nakashima Y, Koh H, Hino M, Nakamae H

    [Rinsho ketsueki] The Japanese journal of clinical hematology   61 ( 3 )   215 - 222   2020( ISSN:0485-1439

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    DOI: 10.11406/rinketsu.61.215

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  • Clinical Characteristics of Rapidly Progressive Fatal Hemorrhagic Pneumonia Caused by Stenotrophomonas maltophilia Reviewed

    Imoto Waki, Yamada Koichi, Yamairi Kazushi, Shibata Wataru, Namikawa Hiroki, Yukawa Satomi, Yoshii Naoko, Nakaie Kiyotaka, Hirose Asao, Koh Hideo, Watanabe Tetsuya, Asai Kazuhisa, Nakamae Hirohisa, Kaneko Yukihiro, Kawaguchi Tomoya, Hino Masayuki, Kakeya Hiroshi

    一般社団法人 日本内科学会 INTERNAL MEDICINE   59 ( 2 )   193 - 198   2020( ISSN:0918-2918

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    <p><b>Objective </b>Hemorrhagic pneumonia due to <i>Stenotrophomonas maltophilia</i> (SM) in severely immunocompromised patients has a very poor prognosis. However, the risk factors for hemorrhagic pneumonia are not clear. </p><p><b>Methods </b>This study assessed the predictive factors of hemorrhagic pneumonia caused by SM. The medical records of patients admitted to Osaka City University Hospital with SM bacteremia between January 2008 and December 2017 were retrospectively reviewed. </p><p><b>Patients </b>All patients who had positive blood cultures for SM were included in this study. They were categorized into two groups: the SM bacteremia with hemorrhagic pneumonia group and the SM bacteremia without hemorrhagic pneumonia group. The clinical background characteristics and treatments were compared between these groups. </p><p><b>Results </b>The 35 patients with SM bacteremia included 4 with hemorrhagic pneumonia and 31 without hemorrhagic pneumonia. Hematologic malignancy (p=0.03) and thrombocytopenia (p=0.04) as well as the prior use of quinolone within 30 days (p=0.04) were more frequent in the SM bacteremia patients with hemorrhagic pneumonia than in those without hemorrhagic pneumonia. The mortality of the SM bacteremia patients with hemorrhagic pneumonia was higher than that of those without hemorrhagic pneumonia group (p=0.02). </p><p><b>Conclusion </b>Patients with SM bacteremia who have hematologic malignancy, thrombocytopenia, and a history of using quinolone within the past 30 days should be treated with deliberation. </p>

    DOI: 10.2169/internalmedicine.3358-19

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    CiNii Article

  • Donor KIR2DS1-Mediated Decreased Relapse and Improved Survival Depending on Remission Status at HLA-Haploidentical Transplantation with Post-Transplantation Cyclophosphamide. Reviewed

    Ido K, Koh H, Hirose A, Okamura H, Koh S, Nanno S, Nishimoto M, Nakamae M, Nakashima Y, Nakane T, Hino M, Nakamae H

    Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation   2019.12( ISSN:1083-8791

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    DOI: 10.1016/j.bbmt.2019.12.765

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  • Pretransplant serum beta-2 microglobulin level is a potential novel prognostic marker of overall survival after allogeneic hematopoietic cell transplantation - a retrospective observational study Reviewed

    Harada Naonori, Nakane Takahiko, Nakamae Mika, Hashimoto Yoshinori, Okamura Hiroshi, Nanno Satoru, Nishimoto Mitsutaka, Hirose Asao, Nakashima Yasuhiro, Koh Hideo, Hino Masayuki, Nakamae Hirohisa

    TRANSPLANT INTERNATIONAL   2019.12( ISSN:0934-0874

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    DOI: 10.1111/tri.13564

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  • Outcomes of Allogeneic Hematopoietic Stem Cell Transplantation for ATL with HTLV-1 Antibody-Positive Donors. Reviewed

    Yoshimitsu M, Fuji S, Utsunomiya A, Nakano N, Ito A, Ito Y, Miyamoto T, Suehiro Y, Kawakita T, Moriuchi Y, Nakamae H, Kanda Y, Ichinohe T, Fukuda T, Atsuta Y, Kato K, ATL Working Group of the Japan Society for Hematopoietic Cell Transplantation.

    Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation   2019.12( ISSN:1083-8791

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    DOI: 10.1016/j.bbmt.2019.12.004

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  • Mosquito allergy: a novel strong prognostic symptom of outcome after allogeneic hematopoietic transplantation. Reviewed

    Koh S, Nakamae H, Nanno S, Nakane T, Nakashima Y, Koh H, Nakamae M, Hirose A, Hino M

    Bone marrow transplantation   2019.12( ISSN:0268-3369

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    DOI: 10.1038/s41409-019-0759-y

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  • Role of alternative donor allogeneic hematopoietic stem cell transplantation in patients with intermediate- or poor-risk acute myeloid leukemia in first complete remission Reviewed

    Yano Shingo, Yokoyama Hiroki, Yanada Masamitsu, Mori Jinichi, Aoki Jun, Ohashi Kazuteru, Kanomori Heiwa, Ozawa Yuichiro, Sawa Masashi, Nakamae Hiroshisa, Eto Tetsuya, Ohta Shuichi, Tanaka Junji, Ichinohe Tatsuo, Atsuta Yoshiko, Takami Akiyoshi

    BONE MARROW TRANSPLANTATION   54 ( 12 )   2004 - 2012   2019.12( ISSN:0268-3369

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    DOI: 10.1038/s41409-019-0571-8

  • Phase I study of graft-versus-host disease prophylaxis including bortezomib for allogeneic hematopoietic cell transplantation from unrelated donors with one or two HLA loci mismatches in Japanese patients(和訳中) Reviewed

    Nakane Takahiko, Okamura Hiroshi, Tagaito Yumi, Koh Shiro, Yoshimura Takuro, Makuuchi Yosuke, Nanno Satoru, Nakamae Mika, Hirose Asao, Nakashima Yasuhiro, Koh Hideo, Hino Masayuki, Nakamae Hirohisa

    (一社)日本血液学会 International Journal of Hematology   110 ( 6 )   736 - 742   2019.12( ISSN:0925-5710

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  • Cessation of nilotinib in patients with chronic myelogenous leukemia who have maintained deep molecular responses for 2 years: a multicenter phase 2 trial, stop nilotinib(NILSt)(和訳中) Reviewed

    Nagafuji Koji, Matsumura Itaru, Shimose Takayuki, Kawaguchi Tatsuya, Kuroda Junya, Nakamae Hirohisa, Miyamoto Toshihiro, Kadowaki Norimitsu, Ishikawa Jun, Imamura Yutaka, Yamazaki Hirohito, Akashi Koichi, Kanakura Yuzuru

    (一社)日本血液学会 International Journal of Hematology   110 ( 6 )   675 - 682   2019.12( ISSN:0925-5710

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  • Unit selection for umbilical cord blood transplantation for adults with acute myeloid leukemia in complete remission: a Japanese experience. Reviewed

    Yanada M, Konuma T, Kuwatsuka Y, Kondo T, Kawata T, Takahashi S, Uchida N, Miyakoshi S, Tanaka M, Ozawa Y, Sawa M, Nakamae H, Aotsuka N, Kanda J, Takanashi M, Kanda Y, Atsuta Y, Yano S

    Bone marrow transplantation   54 ( 11 )   1789 - 1798   2019.11( ISSN:0268-3369

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    DOI: 10.1038/s41409-019-0539-8

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  • Different impact of BCR-ABL transcripts on allogeneic hematopoietic cell transplantation from different graft sources for Ph plus ALL with minimal residual disease Reviewed

    Nishiwaki Satoshi, Mizuta Shuichi, Ohashi Kazuteru, Fukuda Takahiro, Uchida Naoyuki, Tachibana Takayoshi, Onizuka Makoto, Ozawa Yukiyasu, Onishi Yasushi, Takahashi Satoshi, Eto Tetsuya, Nakamae Hirohisa, Tanaka Junji, Ichinohe Tatsuo, Atsuta Yoshiko, Kako Shinichi

    AMERICAN JOURNAL OF HEMATOLOGY   94 ( 11 )   E301 - E305   2019.11( ISSN:0361-8609

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    DOI: 10.1002/ajh.25612

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  • Time-Varying Effects of Graft Type on Outcomes for Patients with Acute Myeloid Leukemia Undergoing Allogeneic Hematopoietic Cell Transplantation. Reviewed

    Yanada M, Konuma T, Yamasaki S, Kuwatsuka Y, Masuko M, Tanaka M, Ozawa Y, Toya T, Fukuda T, Ota S, Sawa M, Uchida N, Nakamae H, Eto T, Kanda J, Takanashi M, Kanda Y, Atsuta Y, Yano S

    Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation   2019.10( ISSN:1083-8791

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    DOI: 10.1016/j.bbmt.2019.09.036

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  • Impact of pretransplant donor-specific anti-HLA antibodies on cord blood transplantation on behalf of the Transplant Complications Working Group of Japan Society for Hematopoietic Cell Transplantation. Reviewed

    Fuji S, Oshima K, Ohashi K, Sawa M, Saito T, Eto T, Tanaka M, Onizuka M, Nakamae H, Shiratori S, Ozawa Y, Hidaka M, Nagamura-Inoue T, Tanaka H, Fukuda T, Ichinohe T, Atsuta Y, Ogata M

    Bone marrow transplantation   2019.10( ISSN:0268-3369

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    DOI: 10.1038/s41409-019-0712-0

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  • Tyrosine kinase inhibitor prophylaxis after transplant for Philadelphia chromosome-positive acute lymphoblastic leukemia Reviewed

    Akahoshi Yu, Nishiwaki Satoshi, Mizuta Shuichi, Ohashi Kazuteru, Uchida Naoyuki, Tanaka Masatsugu, Fukuda Takahiro, Ozawa Yukiyasu, Takahashi Satoshi, Onizuka Makoto, Shiratori Souichi, Nakamae Hirohisa, Kanda Yoshinobu, Ichinohe Tatsuo, Atsuta Yoshiko, Kako Shinichi

    CANCER SCIENCE   110 ( 10 )   3255 - 3266   2019.10( ISSN:1347-9032

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    DOI: 10.1111/cas.14167

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  • Tyrosine kinase inhibitor prophylaxis after transplant for Philadelphia chromosome-positive acute lymphoblastic leukemia(和訳中) Reviewed

    Akahoshi Yu, Nishiwaki Satoshi, Mizuta Shuichi, Ohashi Kazuteru, Uchida Naoyuki, Tanaka Masatsugu, Fukuda Takahiro, Ozawa Yukiyasu, Takahashi Satoshi, Onizuka Makoto, Shiratori Souichi, Nakamae Hirohisa, Kanda Yoshinobu, Ichinohe Tatsuo, Atsuta Yoshiko, Kako Shinichi

    John Wiley & Sons Australia, Ltd Cancer Science   110 ( 10 )   3255 - 3266   2019.10( ISSN:1347-9032

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  • Clinical Impacts of Using Serum IL-6 Level as an Indicator of Cytokine Release Syndrome after HLA-Haploidentical Transplantation with Post-Transplantation Cyclophosphamide Reviewed

    Nishimoto Mitsutaka, Hirose Asao, Koh Hideo, Nakamae Mika, Nanno Satoru, Okamura Hiroshi, Nakane Takahiko, Nakashima Yasuhiro, Hino Masayuki, Nakamae Hirohisa

    BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION   25 ( 10 )   2061 - 2069   2019.10( ISSN:1083-8791

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    DOI: 10.1016/j.bbmt.2019.06.003

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  • Combination of Frailty Status and Comorbidity Score Improves the Stratification of Survival in Patients With Myelodysplastic Syndrome Owing to Good Predictive Capability for Infection-related Mortality. Reviewed

    Sakatoku K, Takeoka Y, Miura A, Araki T, Fujitani Y, Yamamura R, Nakamae H, Ohta K, Hino M

    Clinical lymphoma, myeloma & leukemia   2019.09( ISSN:2152-2650

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    DOI: 10.1016/j.clml.2019.09.610

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  • Phase I study of graft-versus-host disease prophylaxis including bortezomib for allogeneic hematopoietic cell transplantation from unrelated donors with one or two HLA loci mismatches in Japanese patients. Reviewed

    Nakane T, Okamura H, Tagaito Y, Koh S, Yoshimura T, Makuuchi Y, Nanno S, Nakamae M, Hirose A, Nakashima Y, Koh H, Hino M, Nakamae H

    International journal of hematology   2019.09( ISSN:0925-5710

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    DOI: 10.1007/s12185-019-02743-6

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  • Cessation of nilotinib in patients with chronic myelogenous leukemia who have maintained deep molecular responses for 2 years: a multicenter phase 2 trial, stop nilotinib (NILSt). Reviewed

    Nagafuji K, Matsumura I, Shimose T, Kawaguchi T, Kuroda J, Nakamae H, Miyamoto T, Kadowaki N, Ishikawa J, Imamura Y, Yamazaki H, Akashi K, Kanakura Y

    International journal of hematology   2019.09( ISSN:0925-5710

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    DOI: 10.1007/s12185-019-02736-5

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  • A prospective observational study of immune reconstitution following transplantation with post-transplant reduced-dose cyclophosphamide from HLA-haploidentical donors Reviewed

    Nakamae Hirohisa, Fujii Kazuki, Nanno Satoru, Okamura Hiroshi, Nakane Takahiko, Koh Hideo, Nakashima Yasuhiro, Nakamae Mika, Hirose Asao, Teshima Takanori, Hino Masayuki

    TRANSPLANT INTERNATIONAL   2019.09( ISSN:0934-0874

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    DOI: 10.1111/tri.13494

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  • Hematopoietic Stem Cell Transplantation in Solid Organ Recipients with Emphasis on Transplant Complications: A Nationwide Retrospective Survey on Behalf of the Japan Society for Hematopoietic Stem Cell Transplantation Transplant Complications Working Group. Reviewed

    Shinohara A, Oshima K, Fuji S, Umeda K, Kako S, Kurokawa M, Tsukada N, Kasai M, Kondo T, Hashii Y, Nakamae H, Ikegame K, Kosaka Y, Shimada A, Nawa Y, Makoto Y, Yoshiko A, Fukuda T, Tanaka J, Ogata M

    Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation   2019.09( ISSN:1083-8791

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    DOI: 10.1016/j.bbmt.2019.08.021

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  • Bone marrow-derived stromal cells in the tumor microenvironment might be associated with the progression of gastric cancer Reviewed

    Yashiro Masakazu, Kasashima Hiroaki, Kushiyama Syuhei, Nishimura Sadaaki, Kuroda Kenji, Togano Shingo, Okuno Tomohisa, Miki Yuichiro, Fukuoka Tatsunari, Nakamae Hirohisa, Hino Masayuki, Ohira Masaichi

    CANCER RESEARCH   79 ( 13 )   2019.07( ISSN:0008-5472

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    DOI: 10.1158/1538-7445.AM2019-2742

  • BM is preferred over PBSCs in transplantation from an HLA-matched related female donor to a male recipient Reviewed

    Nakasone Hideki, Kawamura Koji, Yakushijin Kimikazu, Shinohara Akihito, Tanaka Masatsugu, Ohashi Kazuteru, Ota Shuichi, Uchida Naoyuki, Fukuda Takahiro, Nakamae Hirohisa, Matsuoka Ken-Ichi, Kanda Junya, Ichinohe Tatsuo, Atsuta Yoshiko, Inamoto Yoshihiro, Seo Sachiko, Kimura Fumihiko, Ogata Masao

    BLOOD ADVANCES   3 ( 11 )   1750 - 1760   2019.06( ISSN:2473-9529

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    DOI: 10.1182/bloodadvances.2019000077

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  • A noninvasive diagnostic approach using per-rectal portal scintigraphy for sinusoidal obstruction syndrome after allogeneic hematopoietic cell transplantation. Reviewed

    Okamura H, Koh H, Takakuwa T, Ido K, Makuuchi Y, Ine S, Nanno S, Nakashima Y, Nakane T, Jogo A, Yamamoto A, Hamuro M, Kotani K, Kawabe J, Higashiyama S, Yoshida A, Shiomi S, Ohsawa M, Hino M, Nakamae H

    Bone marrow transplantation   2019.05( ISSN:0268-3369

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    DOI: 10.1038/s41409-019-0537-x

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  • Aspergillus section Fumigati内の潜在種Aspergillus felisに起因する侵襲性肺アスペルギローシスの治療の成功 症例報告(Successful treatment of invasive pulmonary aspergillosis caused by Aspergillus felis, a cryptic species within the Aspergillus section Fumigati: A case report) Reviewed

    Yamairi Kazushi, Ido Kentaro, Nakamura Shigeki, Niki Makoto, Imoto Waki, Shibata Wataru, Namikawa Hiroki, Fujimoto Hiroki, Yamada Koichi, Nakamae Hirohisa, Hino Masayuki, Kaneko Yukihiro, Miyazaki Yoshitsugu, Kakeya Hiroshi

    エルゼビア・ジャパン(株) Journal of Infection and Chemotherapy   25 ( 3-4 )   307 - 310   2019.04( ISSN:1341-321X

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    41歳女。骨髄異形成症候群と診断されていた。自己末梢血幹細胞移植の施行19日後に発熱し、侵襲性肺アスペルギローシスと診断しボリコナゾール(VRCZ)による治療を開始した。確定診断のため、気管支鏡検査と気管支肺胞洗浄を行った。治療開始1ヵ月後でも患者の肺病変は変化なく、発熱も持続したため、抗菌薬をアンホテリシンBリポソーム製剤に切り替えたところ、副作用の嘔気が出現した。VRCZとカスポファンギン(CPFG)による併用療法を開始した結果、肺病変のサイズが徐々に減少した。気管支肺胞洗浄液から単離した糸状菌のβ-チューブリン遺伝子を、PCR産物からプライマー対を用いて直接配列決定し、Aspergillus felisとの100%の類似性を確認した。次いで実施した感受性試験の結果を基に、抗菌薬をVRCZ+CPFGからミカファンギンに変えると、5ヵ月間で治療が奏効した。

  • Successful treatment of invasive pulmonary aspergillosis caused by Aspergillus felis, a cryptic species within the Aspergillus section Fumigati: A case report Reviewed

    Yamairi Kazushi, Ido Kentaro, Nakamura Shigeki, Niki Makoto, Imoto Waki, Shibata Wataru, Namikawa Hiroki, Fujimoto Hiroki, Yamada Koichi, Nakamae Hirohisa, Hino Masayuki, Kaneko Yukihiro, Miyazaki Yoshitsugu, Kakeya Hiroshi

    JOURNAL OF INFECTION AND CHEMOTHERAPY   25 ( 4 )   307 - 310   2019.04( ISSN:1341-321X

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    DOI: 10.1016/j.jiac.2018.10.016

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  • Short-Term Fasting Induces Cell Cycle Arrest in Immature Hematopoietic Cells and Increases the Number of Naïve T Cells in the Bone Marrow of Mice. Reviewed

    Takakuwa T, Nakashima Y, Koh H, Nakane T, Nakamae H, Hino M

    Acta haematologica   141 ( 3 )   189 - 198   2019.03( ISSN:0001-5792

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    DOI: 10.1159/000496096

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  • Cytomegalovirus reactivation is associated with increased mortality more than 100 days after allogeneic hematopoietic stem cell transplantation for adult T-cell leukemia/lymphoma. Reviewed

    Sawayama Y, Itonaga H, Fukushima T, Nakano N, Fujiwara H, Utsunomiya A, Fukuda T, Miyamoto T, Eto T, Miyashita K, Nakamae H, Ogata M, Yamanoha A, Miyazaki Y, Kanda J, Atsuta Y, Kato K, ATL Working Group of the Japan Society for Hematopoietic Cell Transplantation.

    American journal of hematology   2019.02( ISSN:0361-8609

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    DOI: 10.1002/ajh.25438

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  • The Proportional Relationship between Pre-transplant WT1 mRNA Levels and Risk of Mortality after Allogeneic Hematopoietic Cell Transplantation in Acute Myeloid Leukemia Not in Remission. Reviewed

    Ido K, Nakamae M, Koh H, Okamura H, Nanno S, Nishimoto M, Takeoka Y, Hirose A, Nakashima Y, Hashimoto Y, Nakane T, Hino M, Nakamae H

    Transplantation   2019.02( ISSN:0041-1337

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    DOI: 10.1097/TP.0000000000002662

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  • 末梢性T細胞リンパ腫患者に対する自家造血幹細胞移植の危険因子とタイミング(Risk factors and timing of autologous stem cell transplantation for patients with peripheral T-cell lymphoma) Reviewed

    Yamasaki Satoshi, Chihara Dai, Kim Sung-Won, Kawata Takahito, Mizuta Shuichi, Ago Hiroatsu, Chou Takaaki, Yamane Takahisa, Uchiyama Hitoji, Oyake Tatsuo, Miura Katsuhiro, Saito Bungo, Taji Hirofumi, Nakamae Hirohisa, Miyamoto Toshihiro, Fukuda Takahiro, Kanda Junya, Atsuta Yoshiko, Suzuki Ritsuro

    (一社)日本血液学会 International Journal of Hematology   109 ( 2 )   175 - 186   2019.02( ISSN:0925-5710

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    特定不能末梢性T細胞リンパ腫(PTCL-NOS)と血管免疫芽球性T細胞リンパ腫(AITL)患者での自家造血幹細胞移植(ASCT)のタイミングと転帰に関連する危険因子を解析した。2000年1月〜2015年12月にASCTを受けた患者を後ろ向きに調査した。患者を、frontline consolidationとしてASCTを受けたPTCL-NOS群98例(男性69%、年齢19〜74歳)、AITL群75例(男性65%、年齢22〜73歳)、再発後代替療法としてASCTを受けたPTCL-NOS群112例(男性70%、年齢18〜70歳)、AITL群75例(男性72%、年齢40〜75歳)に分けた。初回寛解導入不能(PIF)後に代替療法としてASCTを受けたPTCL-NOS群127例(男性68%、年齢18〜77歳)、AITL群83例(男性67%、年齢23〜75歳)に分けた。upfront ASCT後の全生存率に対する有意な危険因子は、PTCL-NOS群ではT細胞リンパ腫に対する予後指数α≧2とASCTでの部分寛解、AITL群では>60歳とASCTでの部分寛解であった。PTCL-NOS群のASCTでの活動指標≧2、ASCT前の3以上のレジメン、ASCTでの部分寛解、AITL群のASCT時の>60歳が化学受容性PIF状態のASCT後の全生存率に対する危険因子であった。

  • The outcome and characteristics of patients with relapsed adult T cell leukemia/lymphoma after allogeneic hematopoietic stem cell transplantation Reviewed

    Kato Koji, Uike Naokuni, Wake Atsushi, Yoshimitsu Makoto, Tobai Tomomi, Sawayama Yasushi, Takatsuka Yoshifusa, Fukuda Takahiro, Uchida Naoyuki, Eto Tetsuya, Nakashima Yasuhiro, Kondo Tadakazu, Taguchi Jun, Miyamoto Toshihiro, Nakamae Hirohisa, Ichinohe Tatsuo, Kato Koji, Suzuki Ritsuro, Utsunomiya Atae

    HEMATOLOGICAL ONCOLOGY   37 ( 1 )   54 - 61   2019.02( ISSN:0278-0232

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    DOI: 10.1002/hon.2558

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  • Risk factors and timing of autologous stem cell transplantation for patients with peripheral T-cell lymphoma. Reviewed

    Yamasaki S, Chihara D, Kim SW, Kawata T, Mizuta S, Ago H, Chou T, Yamane T, Uchiyama H, Oyake T, Miura K, Saito B, Taji H, Nakamae H, Miyamoto T, Fukuda T, Kanda J, Atsuta Y, Suzuki R

    International journal of hematology   109 ( 2 )   175 - 186   2019.02( ISSN:0925-5710

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    DOI: 10.1007/s12185-018-2560-x

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  • Induction chemotherapy followed by allogeneic HCT versus upfront allogeneic HCT for advanced myelodysplastic syndrome: A propensity score matched analysis Reviewed

    Konuma Takaaki, Shimomura Yoshimitsu, Ozawa Yukiyasu, Ueda Yasunori, Uchida Naoyuki, Onizuka Makoto, Akiyama Megumi, Mori Takehiko, Nakamae Hirohisa, Ohno Yuju, Shiratori Souichi, Onishi Yasushi, Kanda Yoshinobu, Fukuda Takahiro, Atsuta Yoshiko, Ishiyama Ken

    HEMATOLOGICAL ONCOLOGY   37 ( 1 )   85 - 95   2019.02( ISSN:0278-0232

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    DOI: 10.1002/hon.2566

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  • Impacts of thymoglobulin in patients with acute leukemia in remission undergoing allogeneic HSCT from different donors Reviewed

    Wakamatsu Manabu, Terakura Seitaro, Ohashi Kazuteru, Fukuda Takahiro, Ozawa Yukiyasu, Kanamori Heiwa, Sawa Masashi, Uchida Naoyuki, Ota Shuichi, Matsushita Akiko, Kanda Yoshinobu, Nakamae Hirohisa, Ichinohe Tatsuo, Kato Koji, Murata Makoto, Atsuta Yoshiko, Teshima Takanori

    BLOOD ADVANCES   3 ( 2 )   105 - 115   2019.01( ISSN:2473-9529

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    DOI: 10.1182/bloodadvances.2018025643

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  • Clinical significance of low-dose total body irradiation in HLA-mismatched reduced-intensity stem cell transplantation. Reviewed

    Fujiwara SI, Kanda J, Tatara R, Ogawa H, Fukuda T, Okumura H, Ohashi K, Iwato K, Ueda Y, Ishiyama K, Eto T, Matsuoka KI, Nakamae H, Onizuka M, Atsuta Y, Kanda Y, HLA Working Group of the Japan Society for Hematopoietic Cell Transplantation.

    Bone marrow transplantation   2019.01( ISSN:0268-3369

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    DOI: 10.1038/s41409-019-0434-3

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  • Upfront allogeneic hematopoietic cell transplantation (HCT) versus remission induction chemotherapy followed by allogeneic HCT for acute myeloid leukemia with multilineage dysplasia: A propensity score matched analysis Reviewed

    Konuma Takaaki, Harada Kaito, Yamasaki Satoshi, Mizuno Shohei, Uchida Naoyuki, Takahashi Satoshi, Onizuka Makoto, Nakamae Hirohisa, Hidaka Michihiro, Fukuda Takahiro, Ohashi Kazuteru, Kohno Akio, Matsushita Akiko, Kanamori Heiwa, Ashida Takashi, Kanda Junya, Atsuta Yoshiko, Yano Shingo

    AMERICAN JOURNAL OF HEMATOLOGY   94 ( 1 )   103 - 110   2019.01( ISSN:0361-8609

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    DOI: 10.1002/ajh.25336

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  • 同種造血幹細胞移植後にリンパ還流障害による難治性腹水をきたした急性骨髄性白血病 Reviewed

    高桑 輝人, 奥野 高裕, 西本 光孝, 南野 智, 武岡 康信, 中嶋 康博, 康 秀男, 中根 孝彦, 鰐渕 英機, 日野 雅之, 中前 博久

    (一社)日本血液学会-東京事務局 臨床血液   60 ( 1 )   12 - 16   2019.01( ISSN:0485-1439

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    同種造血幹細胞移植後の難治性腹水の鑑別疾患としては類洞閉塞症候群、感染症、原疾患の再発および浸潤、低栄養などが知られているが、しばしば原因特定が困難な症例に遭遇する。症例は59歳の男性で、急性骨髄性白血病の血液学的再発に対して同種骨髄移植を施行された。移植後3ヵ月頃より乳び腹水が出現し、リンパ管シンチでは乳び槽レベルでのリンパ流停滞がみられたが、腹水に対する有効な治療は見いだせなかった。死後の病理組織から肝臓や消化管にGVHDはみられず、白血病細胞の残存も認めなかった。膵臓については急性膵炎の像に加え、膵実質の線維化や形質細胞の浸潤があり、慢性的な炎症が併存しており、膵炎によるリンパ還流障害が腹水を引き起こしていた可能性が示唆された。本症例は生前には膵炎の確定診断に至らなかった。移植後の無症候性膵炎は少なくない可能性があり、鑑別疾患として、留意する必要があると考えられた。(著者抄録)

  • Current status of HLA haplo-identical transplantation using post-transplantation cyclophosphamide Reviewed

    Nakamae Hirohisa

    The Japan Society for Hematopoietic Stem Cell Transplantation, Journal of Hematopoietic Cell Transplantation   8 ( 1 )   16 - 21   2019

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    <p> Outcomes of HLA haplo-identical transplantation using post-transplantation cyclophosphamide (PT/Cy-haplo) are similar to those of HLA-matched related/unrelated transplantation. Unlike classical HLA haplo-identical transplantation, PT/Cy-haplo does not require expensive T-cell depletion. Furthermore, accumulating evidences, including meta-analysis data, have indicated that PT/Cy-haplo may have a significant advantage over HLA-matched transplantation, concerning the low incidence of clinically significant, moderate-to-severe chronic graft-versus-host disease. This clinical advantage of PT/Cy-haplo could contribute to economic medical benefits by reducing the cost and improve the quality of life of the patients. The establishment of PT/Cy-haplo could necessitate the recalibration of the donor selection algorithm.</p>

    DOI: 10.7889/hct-18-008

    CiNii Article

  • Refractory ascites caused by lymphatic flow disorder after stem cell transplantation for acute myeloid leukemia Reviewed

    TAKAKUWA Teruhito, HINO Masayuki, NAKAMAE Hirohisa, OKUNO Takahiro, NISHIMOTO Mitsutaka, NANNO Satoru, TAKEOKA Yasunobu, NAKASHIMA Yasuhiro, KOH Hideo, NAKANE Takahiko, WANIBUCHI Hideki

    The Japanese Society of Hematology, Rinsho Ketsueki   60 ( 1 )   12 - 16   2019( ISSN:0485-1439

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    <p>In allogeneic hematopoietic stem cell transplantation (HSCT), ascites may develop owing to several causes, including sinusoidal obstruction syndrome, infections, malignancies, and malnutrition. However, it is often difficult to determine its precise cause. Here, a 59-year-old male developed chylous ascites three months post allogeneic bone marrow transplantation for relapsed acute myeloid leukemia. None of the attempted treatments resulted in improvement. Lymphangioscintigraphy revealed a lymphatic flow disorder at the level of the cisterna chyli. Autopsy revealed no leukemic cell infiltration or graft-versus-host disease of the liver or pancreas. The pancreatic specimen revealed parenchymal fibrosis and infiltration of plasma cells, suggesting chronic inflammation in addition to pathological changes caused by acute pancreatitis. These findings indicate that acute or chronic pancreatitis caused a lymphatic flow disorder that developed into refractory ascites. Although we could not diagnose pancreatitis while the patient was alive, it is important to recognize that asymptomatic pancreatitis can develop after HSCT. Furthermore, one should attempt to make an accurate diagnosis as early as possible.</p>

    DOI: 10.11406/rinketsu.60.12

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    CiNii Article

  • HLA discrepancy between graft and host rather than that graft and first donor impact the second transplant outcome. Reviewed

    Maeda Y, Ugai T, Kondo E, Ikegame K, Murata M, Uchida N, Miyamoto T, Takahashi S, Ohashi K, Nakamae H, Fukuda T, Onizuka M, Eto T, Ota S, Hirokawa M, Ichinohe T, Atsuta Y, Kanda Y, Kanda J

    Haematologica   2018.12( ISSN:0390-6078

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    DOI: 10.3324/haematol.2018.204438

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  • Rituximabが有効であったHLA半合致移植後の脊髄長大病変を伴う再発性急性散在性脳脊髄炎 Reviewed

    幕内 陽介, 西本 光孝, 山本 圭一, 高橋 利幸, 久野 雅智, 中嶋 康博, 康 秀男, 中根 孝彦, 日野 雅之, 中前 博久

    (一社)日本血液学会-東京事務局 臨床血液   59 ( 12 )   2588 - 2593   2018.12( ISSN:0485-1439

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    同種造血幹細胞移植後の慢性移植片対宿主病(graft-versus-host disease、GVHD)に起因する中枢神経疾患は稀であり、その病態や治療法には不明な点が多い。我々は急性混合性白血病に対して移植後大量シクロフォスファミドを用いたHLA半合致同種末梢血幹細胞移植を行い、慢性GVHDに起因した脊髄長大病変を伴う再発性の急性散在性脳脊髄炎(acute disseminated encephalomyelitis、ADEM)を合併した1症例を経験した。ステロイド治療に抵抗性を認めたがrituximabの投与が有効であった。我々が知る限り、脊髄長大病変というADEMにおいては非典型的な病変形成に慢性GVHDが寄与し、またこの病態に対してrituximabが有効であった報告は他にない。同種造血細胞移植後の慢性GVHD患者に生じた神経症状の鑑別としてADEMの可能性を考慮するべきと考えられる。(著者抄録)

  • Pre-Transplant Serum Beta-2 Microglobulin Level Is a Potential Novel Prognostic Marker for Overall Survival after Allogeneic Hematopoietic Stem Cell Transplantation Reviewed

    Harada Naonori, Nakane Takahiko, Nakamae Mika, Okamura Hiroshi, Nanno Satoru, Nishimoto Mitsutaka, Takeoka Yasunobu, Hirose Asao, Nakashima Yasuhiro, Koh Hideo, Hino Masayuki, Nakamae Hirohisa

    BLOOD   132   2018.11( ISSN:0006-4971

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    DOI: 10.1182/blood-2018-99-111679

  • Allogeneic hematopoietic cell transplantation in adult acute myeloid leukemia with 11q23 abnormality: a retrospective study of the Adult Acute Myeloid Leukemia Working Group of the Japan Society for Hematopoietic Cell Transplantation (JSHCT) Reviewed

    Konuma Takaaki, Mizuno Shohei, Kondo Tadakazu, Yamaguchi Hiroki, Fukuda Takahiro, Uchida Naoyuki, Najima Yuho, Kanamori Heiwa, Ota Shuichi, Nakamae Hirohisa, Nakamae Mika, Mizuno Ishikazu, Sugita Junichi, Onishi Yasushi, Yokota Akira, Takahashi Satoshi, Kanda Yoshinobu, Ichinohe Tatsuo, Atsuta Yoshiko, Yano Shingo

    ANNALS OF HEMATOLOGY   97 ( 11 )   2173 - 2183   2018.11( ISSN:0939-5555

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00277-018-3419-1

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  • Validation of previous prognostic models for thrombosis and exploration of modified models in patients with essential thrombocythemia Reviewed

    Hashimoto Yoshinori, Nakamae Hirohisa, Tanaka Takayuki, Omura Hiromi, Horiuchi Mirei, Yoshimura Takuro, Takakuwa Teruhito, Mugitani Atsuko, Hirose Asao, Nakamae Mika, Koh Hideo, Hino Masayuki

    EUROPEAN JOURNAL OF HAEMATOLOGY   101 ( 4 )   508 - 513   2018.10( ISSN:0902-4441

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/ejh.13136

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  • Defibrotide for Prophylaxis of Hepatic Veno-Occlusive Disease Hematopoietic Stem Cell Transplantation: Results from the Japanese Prophylactic Use, Phase II, Randomized Trial Reviewed

    Kikuta Atsushi, Fukuda Takahiro, Ohashi Kazuteru, Taniguchi Shuichi, Asano-Mori Yuki, Horibe Keizo, Goto Hiroaki, Nakamae Hirohisa, Ogawa Hiroyasu, Tamaki Hiroya, Takahashi Yoshiyuki, Kimura Toshimi, Yoshimura Kenichi, Umemura Kazuo, Ogawa Chitose

    BONE MARROW TRANSPLANTATION   53   316 - 317   2018.09( ISSN:0268-3369

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  • Defibrotide for Treatment of Hepatic Veno-Occlusive Disease Following Hematopoietic Stem Cell Transplantation: Results from the Japanese Therapeutic Use Protocol Reviewed

    Kikuta Atsushi, Fukuda Takahiro, Ohashi Kazuteru, Taniguchi Shuichi, Asano-Mori Yuki, Horibe Keizo, Goto Hiroaki, Nakamae Hirohisa, Ogawa Hiroyasu, Tamaki Hiroya, Takahashi Yoshiyuki, Kimura Toshimi, Yoshimura Kenichi, Umemura Kazuo, Ogawa Chitose

    BONE MARROW TRANSPLANTATION   53   318 - 319   2018.09( ISSN:0268-3369

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  • Impact of chromosomal abnormality in ATL patients who received allogeneic hematopoietic transplantation. An Analysis on behalf of JSHCT-ATL-WG Reviewed

    Nakano Nobuaki, Utsunomiya Atae, Matsuo Keitaro, Fujiwara Hiroshi, Fuji Sigeo, Takatsuka Yoshifusa, Fukuda Takahiro, Miyamoto Toshihiro, Miyashita Kaname, Nakamae Hirohisa, Sawayama Yasushi, Yuasa Mitsuhiro, Ichinohe Tatsuo, Atsuta Yoshiko, Kato Koji

    BONE MARROW TRANSPLANTATION   53   105 - 106   2018.09( ISSN:0268-3369

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  • Patients with acute myeloid leukemia undergoing allogeneic hematopoietic cell transplantation: trends in survival during the past two decades. Reviewed

    Yanada M, Masuko M, Mori J, Aoki J, Mizuno S, Fukuda T, Kakihana K, Ozawa Y, Ota S, Kanamori H, Mori T, Nakamae H, Eto T, Shiratori S, Maeda T, Iwato K, Ichinohe T, Kanda Y, Tanaka J, Atsuta Y, Yano S

    Bone marrow transplantation   2018.08( ISSN:0268-3369

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    DOI: 10.1038/s41409-018-0301-7

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  • Outcomes of patients who developed subsequent solid cancer after hematopoietic cell transplantation Reviewed

    Inamoto Yoshihiro, Matsuda Tomohiro, Tabuchi Ken, Kurosawa Saiko, Nakasone Hideki, Nishimori Hisakazu, Yamasaki Satoshi, Doki Noriko, Iwato Koji, Mori Takehiko, Takahashi Satoshi, Yabe Hiromasa, Kohno Akio, Nakamae Hirohisa, Sakura Toru, Hashimoto Hisako, Sugita Junichi, Ago Hiroatsu, Fukuda Takahiro, Ichinohe Tatsuo, Atsuta Yoshiko, Yamashita Takuya

    BLOOD ADVANCES   2 ( 15 )   1901 - 1913   2018.08( ISSN:2473-9529

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    DOI: 10.1182/bloodadvances.2018020966

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  • Prophylactic Combined Use of Anticoagulant Agent and Ursodeoxycholic Acid for Sinusoidal Obstruction Syndrome after Allogeneic Myeloablative Hematopoietic Stem Cell Transplantation(和訳中) Reviewed

    Okamura Hiroshi, Koh Hideo, Nishimoto Mitsutaka, Nakane Takahiko, Nakashima Yasuhiro, Nakamae Mika, Hirose Asao, Hino Masayuki, Nakamae Hirohisa

    大阪市医学会 Osaka City Medical Journal   64 ( 1 )   43 - 54   2018.06( ISSN:0030-6096

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  • Final 3-year Results of the Dasatinib Discontinuation Trial in Patients With Chronic Myeloid Leukemia Who Received Dasatinib as a Second-line Treatment Reviewed

    Okada Masaya, Imagawa Jun, Tanaka Hideo, Nakamae Hirohisa, Hino Masayuki, Murai Kazunori, Ishida Yoji, Kumagai Takashi, Sato Seiichi, Ohashi Kazuteru, Sakamaki Hisashi, Wakita Hisashi, Uoshima Nobuhiko, Nakagawa Yasunori, Minami Yosuke, Ogasawara Masahiro, Takeoka Tomoharu, Akasaka Hiroshi, Utsumi Takahiko, Uike Naokuni, Sato Tsutomu, Ando Sachiko, Usuki Kensuke, Mizuta Syuichi, Hashino Satoshi, Nomura Tetsuhiko, Shikami Masato, Fukutani Hisashi, Ohe Yokiko, Kosugi Hiroshi, Shibayama Hirohiko, Maeda Yasuhiro, Fukushima Toshihiro, Yamazaki Hirohito, Tsubaki Kazuo, Kukita Toshimasa, Adachi Yoko, Nataduka Toshiki, Sakoda Hiroto, Yokoyama Hisayuki, Okamoto Takahiro, Shirasugi Yukari, Onishi Yasushi, Nohgawa Masaharu, Yoshihara Satoshi, Morita Satoshi, Sakamoto Junichi, Kimura Shinya

    CLINICAL LYMPHOMA MYELOMA & LEUKEMIA   18 ( 5 )   353 - +   2018.05( ISSN:2152-2650

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    DOI: 10.1016/j.clml.2018.03.004

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  • イマチニブで分子遺伝学的大奏効となったCML-CP患者におけるニロチニブ切り替えの有効性と安全性 多施設共同第II相試験(NILSw試験)の結果(Efficacy and safety of switching to nilotinib in patients with CML-CP in major molecular response to imatinib: results of a multicenter phase II trial(NILSw trial)) Reviewed

    Ishikawa Jun, Matsumura Itaru, Kawaguchi Tatsuya, Kuroda Junya, Nakamae Hirohisa, Miyamoto Toshihiro, Matsuoka Ken-ichi, Shibayama Hirohiko, Hino Masayuki, Hirase Chikara, Kamimura Tomohiko, Shimose Takayuki, Akashi Koichi, Kanakura Yuzuru

    (一社)日本血液学会 International Journal of Hematology   107 ( 5 )   535 - 540   2018.05( ISSN:0925-5710

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    18ヵ月以上のイマチニブ治療で持続検出可能BCR-ABL1転写レベルの分子遺伝学的大奏効(MMR)を達成した日本人の慢性期慢性骨髄性白血病(CML-CP)患者38例(男性29例、女性9例、年齢22〜76歳)を対象に、ニロチニブ(400mg 1日2回)切り替えの有効性と安全性について検討した(NILSw試験)。BCR-ABL1転写レベルを3ヵ月ごとに評価した。27例が24ヵ月のニロチニブ治療を完遂した。20例(52.6%)が深い分子遺伝学的奏効(DMR)を達成し、3、6、9、12、15、18、21ヵ月時の累積DMR達成率はそれぞれ22.9%、37.7%、47.0%、53.7%、53.7%、53.7%、53.7%であった。有害事象は過去のニロチニブの研究における報告と一致し、心血管合併症として、グレード2心房細動、グレード1胸部圧迫感/呼吸困難、グレード2心筋梗塞、グレード3心不全を各1例ずつ認めた。長期イマチニブ治療後にMMRを達成したCML-CP患者において、ニロチニブへの変更によりDMR導入が速やかに得られることが示された。

  • 混合表現型急性白血病、B/myeloid型、非特異型で構成された非白血病性の肉腫の初めての症例(The First Case of Non-leukemic Sarcoma Composed of Mixed-phenotype Acute Leukemia, B/myeloid, Not Otherwise Specified) Reviewed

    Takakuwa Teruhito, Nakane Takahiko, Ohsawa Masahiko, Nagasaki Joji, Aoyama Yasutaka, Nishimoto Mitsutaka, Hayashi Yoshiki, Kuwae Yuko, Hino Masayuki, Nakamae Hirohisa

    (一社)日本内科学会 Internal Medicine   57 ( 8 )   1155 - 1158   2018.04( ISSN:0918-2918

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    症例は61歳女性で、右側の乳癌手術後に放射線照射と20ヵ月間にわたるアロマターゼ阻害薬治療を受けていた。経過観察中のCTで縦隔腫瘍が認められ、PET-CT検査では右側の胸膜、気管前リンパ節、鎖骨上窩リンパ節に高集積病変が示された。血液検査では白血球数が3.6×10^9/L、血小板数が12.4×10^9/Lで、さらに潜在性甲状腺機能低下症も示された。骨髄の分析では軽度の骨髄機能低下が認められたが悪性細胞の浸潤はみられず、骨髄機能低下は甲状腺機能低下に起因するものと推測した。右側胸膜の肥厚病変の生検からび漫性大細胞型B細胞リンパ腫と診断した。神経症状も出現したことから直ちにリツキシマブ併用によるCHOP化学療法を開始したが、その開始後になって検体中に好酸性骨髄球が少数散在してみられることに気がついた。そのためさらなる免疫組織化学的解析を施行し、さらに気管前リンパ節を切除して蛍光in situハイブリダイゼーションなどでの解析も行った結果、先の診断は誤りであり、2008年のWHO分類における混合表現型急性白血病、B/myeloid型、非特異型との最終診断に至った。化学療法のレジメンをhyper-CVAD/MAに変更しリツキシマブを併用して完全寛解を達成した。さらに減量強度前処置による臍帯血移植を施行し、その19ヵ月後の時点で完全寛解にあり生存中である。

  • Outcomes of Patients Who Developed Secondary Solid Cancer after Hematopoietic Cell Transplantation: JSHCT Late Effects and QOL WG Study Reviewed

    Inamoto Yoshihiro, Matsuda Tomohiro, Tabuchi Ken, Kurosawa Saiko, Doki Noriko, Iwato Koji, Mori Takehiko, Takahashi Satoshi, Yabe Hiromasa, Kohno Akio, Nakamae Hirohisa, Fukuda Takahiro, Ichinohe Tatsuo, Atsuta Yoshiko, Yamashita Takuya

    BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION   24 ( 3 )   S27 - S28   2018.03( ISSN:1083-8791

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  • Nilotinib vs. imatinib in Japanese patients with newly diagnosed chronic myeloid leukemia in chronic phase: long-term follow-up of the Japanese subgroup of the randomized ENESTnd trial Reviewed

    Nakamae Hirohisa, Fukuda Tetsuya, Nakaseko Chiaki, Kanda Yoshinobu, Ohmine Ken, Ono Takaaki, Matsumura Itaru, Matsuda Akira, Aoki Makoto, Ito Kazuo, Shibayama Hirohiko

    INTERNATIONAL JOURNAL OF HEMATOLOGY   107 ( 3 )   327 - 336   2018.03( ISSN:0925-5710

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    DOI: 10.1007/s12185-017-2353-7

    PubMed

  • 慢性期に慢性骨髄性白血病と新規診断された日本人患者におけるニロチニブとイマチニブ投与の比較検討 ランダム化ENESTnd試験の日本人サブグループによる長期経過観察(Nilotinib vs. imatinib in Japanese patients with newly diagnosed chronic myeloid leukemia in chronic phase: long-term follow-up of the Japanese subgroup of the randomized ENESTnd trial) Reviewed

    Nakamae Hirohisa, Fukuda Tetsuya, Nakaseko Chiaki, Kanda Yoshinobu, Ohmine Ken, Ono Takaaki, Matsumura Itaru, Matsuda Akira, Aoki Makoto, Ito Kazuo, Shibayama Hirohiko

    (一社)日本血液学会 International Journal of Hematology   107 ( 3 )   327 - 336   2018.03( ISSN:0925-5710

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    国際的な第III相試験であるEvaluating Nilotinib Efficacy and Safety in Clinical Trials? Newly Diagnosed Patients (ENESTnd)において、慢性期に新たに診断された慢性骨髄性白血病(CML-CP)治療におけるニロチニブ300および400mg1日2回投与とイマチニブ400mg1日1回投与の治療効果について比較検討を行った。ENESTndに収集された全846例の治療結果から、ニロチニブはイマチニブよりも高い奏効率が認められ、耐容性も良好であることが確認された。さらに、ENESTndにおける日本人患者の治療成績を1年の経過観察後に解析した結果においても、同様の傾向が示された。また、5年間の経過観察に基づき、日本人サブグループを新たに解析したところ、ニロチニブ300mg投与群が29例、ニロチニブ400mg投与群が23例、イマチニブ投与群が25例の日本人患者において、それぞれ86.2%、78.3%、60.0%の分子遺伝学的効果が得られ、それぞれ65.5%、69.6%、40.0%のMR4.5が達成し、安全性評価においても、前報の治療成績との一致が認められた。なお、ニロチニブ400mgを1日2回投与していた患者1例が治療中に原因不明で死亡したが、ほとんどの患者は加速期/急性転化期に病勢進行はみられなかった。

  • Efficacy and safety of switching to nilotinib in patients with CML-CP in major molecular response to imatinib: results of a multicenter phase II trial (NILSw trial). Reviewed

    Ishikawa J, Matsumura I, Kawaguchi T, Kuroda J, Nakamae H, Miyamoto T, Matsuoka KI, Shibayama H, Hino M, Hirase C, Kamimura T, Shimose T, Akashi K, Kanakura Y

    International journal of hematology   2018.01( ISSN:0925-5710

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    DOI: 10.1007/s12185-018-2401-y

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  • Diagnostic value of serum ferritin and cytokine profiles of hemophagocytic syndrome following allogeneic hematopoietic cell transplantation: methodological issues Reviewed

    Koh Hideo, Nanno Satoru, Hino Masayuki, Nakamae Hirohisa

    LEUKEMIA & LYMPHOMA   59 ( 3 )   772 - 773   2018( ISSN:1042-8194

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    DOI: 10.1080/10428194.2017.1361033

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  • Successful treatment with rituximab in acute disseminated encephalomyelitis with whole spinal cord involvement following HLA haploidentical transplantation Reviewed

    MAKUUCHI Yosuke, NAKAMAE Hirohisa, NISHIMOTO Mitsutaka, YAMAMOTO Keiichi, TAKAHASHI Toshiyuki, KUNO Masatomo, NAKASHIMA Yasuhiro, KOH Hideo, NAKANE Takahiko, HINO Masayuki

    The Japanese Society of Hematology, Rinsho Ketsueki   59 ( 12 )   2588 - 2593   2018( ISSN:0485-1439

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    <p>Chronic graft versus host disease (cGVHD) of the central nervous system is a rare condition that could occur after allogeneic hematopoietic stem cell transplantation (SCT) but has been poorly documented. Here, we report a patient diagnosed with recurrent acute disseminated encephalomyelitis (ADEM) with longitudinal extensive transverse myelitis (LETM) as cGVHD after HLA haploidentical peripheral blood SCT using posttransplantation cyclophosphamide for mixed-phenotype acute leukemia. We observed clinical and radiological improvement after the rituximab treatment of the condition that had been refractory to steroids. To the best of our knowledge, no report of cGVHD presented recurrent ADEM with LETM after allogeneic SCT and successfully treated with rituximab. Hence, ADEM should be included in the differential diagnosis of neurological symptoms in posttransplant patients with cGVHD.</p>

    DOI: 10.11406/rinketsu.59.2588

    PubMed

    CiNii Article

  • Homozygous HLA-C1 is Associated with Reduced Risk of Relapse after HLA-Matched Transplantation in Patients with Myeloid Leukemia. Reviewed

    Arima N, Kanda J, Tanaka J, Yabe T, Morishima Y, Kim SW, Najima Y, Ozawa Y, Eto T, Kanamori H, Mori T, Kobayashi N, Kondo T, Nakamae H, Uchida N, Inoue M, Fukuda T, Ichinohe T, Atsuta Y, Kanda Y

    Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation   2017.12( ISSN:1083-8791

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    DOI: 10.1016/j.bbmt.2017.11.029

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  • The First Case of Non-leukemic Sarcoma Composed of Mixed-phenotype Acute Leukemia, B/myeloid, Not Otherwise Specified. Reviewed

    Takakuwa T, Nakane T, Ohsawa M, Nagasaki J, Aoyama Y, Nishimoto M, Hayashi Y, Kuwae Y, Hino M, Nakamae H

    一般社団法人 日本内科学会 Internal medicine (Tokyo, Japan)   2017.12( ISSN:0918-2918

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    <p>Isolated sarcoma with features of mixed-phenotype acute leukemia (MPAL) is an extremely rare disease and it can be easily misdiagnosed as lymphoma or other malignancies. We herein report the case of a 61-year-old woman with non-leukemic sarcoma of the right pleura, pretracheal lymph node, and supraclavicular lymph node with features of MPAL, B/myeloid, not otherwise specified, which was first misdiagnosed as diffuse large B cell lymphoma. After performing a detailed re-examination of the biopsy specimens, few scattered eosinophilic myelocytes allowed us to reach a correct diagnosis of MPAL and the patient was thereafter successfully treated by intensified chemotherapy followed by cord blood transplantation. </p>

    DOI: 10.2169/internalmedicine.9144-17

    PubMed

    CiNii Article

  • Impact of a Low CD34<sup>+</sup> Cell Dose on Allogeneic Peripheral Blood Stem Cell Transplantation. Reviewed

    Yamamoto C, Ogawa H, Fukuda T, Igarashi A, Okumura H, Uchida N, Hidaka M, Nakamae H, Matsuoka KI, Eto T, Ichinohe T, Atsuta Y, Kanda Y

    Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation   2017.11( ISSN:1083-8791

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    DOI: 10.1016/j.bbmt.2017.10.043

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  • Autonomic Nervous System Pretransplant Malfunction Is a Powerful Predictor of Survival After Allogeneic Hematopoietic Cell Transplantation Reviewed

    Nakane Takahiko, Nakamae Mika, Koh Hideo, Nishimoto Mitsutaka, Nakashima Yasuhiro, Hirose Asao, Hino Masayuki, Nakamae Hirohisa

    TRANSPLANTATION   101 ( 11 )   2801 - 2809   2017.11( ISSN:0041-1337

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    DOI: 10.1097/TP.0000000000001813

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  • Ponatinib in Japanese patients with Philadelphia chromosome-positive leukemia, a phase 1/2 study Reviewed

    Tojo Arinobu, Kyo Taiichi, Yamamoto Kazuhito, Nakamae Hirohisa, Takahashi Naoto, Kobayashi Yukio, Tauchi Tetsuzo, Okamoto Shinichiro, Miyamura Koichi, Hatake Kiyohiko, Iwasaki Hiromi, Matsumura Itaru, Usui Noriko, Naoe Tomoki, Tugnait Meera, Narasimhan Narayana I., Lustgarten Stephanie, Farin Heinrich, Haluska Frank, Ohyashiki Kazuma

    INTERNATIONAL JOURNAL OF HEMATOLOGY   106 ( 3 )   385 - 397   2017.09( ISSN:0925-5710

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    DOI: 10.1007/s12185-017-2238-9

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  • Drug interactions and safety profiles with concomitant use of caspofungin and calcineurin inhibitors in allogeneic haematopoietic cell transplantation Reviewed

    Nishimoto Mitsutaka, Koh Hideo, Tokuwame Atsushi, Makuuchi Yosuke, Kuno Masatomo, Takakuwa Teruhito, Okamura Hiroshi, Koh Shiro, Yoshimura Takuro, Nanno Satoru, Nakamae Mika, Hirose Asao, Nakashima Yasuhiro, Nakane Takahiko, Hino Masayuki, Nakamae Hirohisa

    BRITISH JOURNAL OF CLINICAL PHARMACOLOGY   83 ( 9 )   2000 - 2007   2017.09( ISSN:0306-5251

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    DOI: 10.1111/bcp.13303

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  • Clinical impact of pretransplant use of multiple tyrosine kinase inhibitors on the outcome of allogeneic hematopoietic stem cell transplantation for chronic myelogenous leukemia Reviewed

    Kondo Takeshi, Nagamura-Inoue Tokiko, Tojo Arinobu, Nagamura Fumitaka, Uchida Naoyuki, Nakamae Hirohisa, Fukuda Takahiro, Mori Takehiko, Yano Shingo, Kurokawa Mineo, Ueno Hironori, Kanamori Heiwa, Hashimoto Hisako, Onizuka Makoto, Takanashi Minoko, Ichinohe Tatsuo, Atsuta Yoshiko, Ohashi Kazuteru

    AMERICAN JOURNAL OF HEMATOLOGY   92 ( 9 )   902 - 908   2017.09( ISSN:0361-8609

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    DOI: 10.1002/ajh.24793

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  • フィラデルフィア染色体陽性白血病の日本人患者におけるポナチニブ投与に関する第1/2相試験(Ponatinib in Japanese patients with Philadelphia chromosome-positive leukemia, a phase 1/2 study) Reviewed

    Tojo Arinobu, Kyo Taiichi, Yamamoto Kazuhito, Nakamae Hirohisa, Takahashi Naoto, Kobayashi Yukio, Tauchi Tetsuzo, Okamoto Shinichiro, Miyamura Koichi, Hatake Kiyohiko, Iwasaki Hiromi, Matsumura Itaru, Usui Noriko, Naoe Tomoki, Tugnait Meera, Narasimhan Narayana I., Lustgarten Stephanie, Farin Heinrich, Haluska Frank, Ohyashiki Kazuma

    (一社)日本血液学会 International Journal of Hematology   106 ( 3 )   385 - 397   2017.09( ISSN:0925-5710

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    ダサチニブまたはニロチニブに抵抗性/不耐容の慢性骨髄性白血病(CML)患者、または1つ以上のチロシンキナーゼ阻害剤に抵抗性/不耐容のフィラデルフィア染色体陽性急性リンパ芽球性白血病患者を対象に、ポナチニブの安全性と推奨用量を評価する臨床第1/2相試験を行った。対象は、第I相試験では17名(男11名、年齢中央値62歳)、第II相試験では18名(男9名、年齢中央値60歳)とした。その結果、主要細胞遺伝学的応答は、慢性期CML患者の65%で12ヵ月後まで達成/維持された。主要血液学的応答は、進行期患者の61%で6ヵ月後まで達成された。治療中に発生したグレード3/4の非血液学的有害事象(AE)は高血圧で、37%で認められた。グレード3/4の血液学的AEは血小板減少が57%、好中球減少が34%、白血球減少が26%であった。全体では5名の患者で動脈閉塞事象(AOE)が認められたが、グレード5のAOEは報告されなかった。ポナチニブの曲線下面積に基づく定常状態蓄積比は、2.6(15mg/日)〜1.3(45mg/日)の範囲で、安全性データからみた推奨開始用量は45mg/日であった。

  • 高用量メチルプレドニゾロン静注に応答した抗好中球抗体陽性無顆粒球症の高齢女性(An Elderly Woman with Anti-neutrophil Antibody-positive Agranulocytosis Who Responded to High-dose Intravenous Methylprednisolone) Reviewed

    Koh Shiro, Koh Hideo, Kubo Yuki, Kuroda Maiko, Nishimoto Mitsutaka, Yoshimura Takuro, Nakashima Yasuhiro, Nakane Takahiko, Nakamae Hirohisa, Ohsawa Masahiko, Hino Masayuki

    (一社)日本内科学会 Internal Medicine   56 ( 16 )   2199 - 2203   2017.08( ISSN:0918-2918

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    症例は69歳女性で、2ヵ月前に原因不明の皮疹が出現し、その後、高熱、咽喉痛、全身疲労がみられた。今回、進行性白血球減少症と持続性発熱のため入院となった。数年間にわたり降圧薬、抗脂質異常薬、血栓予防目的でアスピリンを服用しており、1年前からは非ウイルス性肝炎に対してウルソデオキシコール酸を処方していた。所見から薬剤誘導性無顆粒球症と仮診断し、全ての処方薬を中止した。4日目にG-CSF投与とラミナエアフロー隔離を行った。広域抗生物質投与により高熱と咽頭痛は改善したが、好中球数は回復しなかった。その後、重度肺炎を発症し、11日目のCTで前縦隔腫瘍が明らかになった。G-CSF投与を継続した上で、20日目から高用量メチルプレドニゾロン静注療法(1g/日を3日間)を開始し、その後プレドニゾロン(1mg/kg)を投与した。40日目には好中球数が次第に正常範囲に改善したが、アスペルギルス肺炎と脳出血により46日目に死亡した。

  • Therapy-related acute myeloid leukemia and myelodysplastic syndrome after hematopoietic cell transplantation for lymphoma Reviewed

    Yamasaki S., Suzuki R., Hatano K., Fukushima K., Iida H., Morishima S., Suehiro Y., Fukuda T., Uchida N., Uchiyama H., Ikeda H., Yokota A., Tsukasaki K., Yamaguchi H., Kuroda J., Nakamae H., Adachi Y., Matsuoka K-I, Nakamura Y., Atsuta Y., Suzumiya J.

    BONE MARROW TRANSPLANTATION   52 ( 7 )   969 - 976   2017.07( ISSN:0268-3369

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    DOI: 10.1038/bmt.2017.52

  • FINAL STUDY RESULTS OF DISCONTINUATION OF DASATINIB IN PATIENTS WITH CML WHO MAINTAINED DEEP MOLECULAR RESPONSE FOR LONGER THAN ONE YEAR (DADI TRIAL) AFTER THREE YEARS OF FOLLOW-UP Reviewed

    Nakamae H., Imagawa J., Tanaka H., Okada M., Hino M., Murai K., Ishida Y., Kumagai T., Sato S., Ohashi K., Sakamaki H., Wakita H., Uoshima N., Nakagawa Y., Minami Y., Ogasawara M., Takeoka T., Akasaka H., Utsumi T., Uike N., Sato T., Ando S., Usuki K., Morita S., Sakamoto J., Kimura S.

    HAEMATOLOGICA   102   77 - 77   2017.06( ISSN:0390-6078

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  • Clinicopathologic significance of the CXCL1-CXCR2 axis in the tumor microenvironment of gastric carcinoma Reviewed

    Kasashima Hiroaki, Yashiro Masakazu, Nakamae Hirohisa, Masuda Go, Kinoshita Haruhito, Morisaki Tamami, Fukuoka Tatsunari, Hasegawa Tsuyoshi, Nakane Takahiko, Hino Masayuki, Hirakawa Kosei, Ohira Masaichi

    PLOS ONE   12 ( 6 )   e0178635   2017.06( ISSN:1932-6203

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    DOI: 10.1371/journal.pone.0178635

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  • Dasatinib versus imatinib in Japanese patients with newly diagnosed chronic phase chronic myeloid leukemia: a subanalysis of the DASISION 5-year final report Reviewed

    Nakamae Hirohisa, Fujisawa Shin, Ogura Michinori, Uchida Toshiki, Onishi Yasushi, Taniwaki Masafumi, Utsunomiya Atae, Matsue Kosei, Takamatsu Yasushi, Usuki Kensuke, Tanimoto Mitsune, Ishida Yoji, Ohashi Kazuteru, Li Li, Miyoshi Masafumi

    INTERNATIONAL JOURNAL OF HEMATOLOGY   105 ( 6 )   792 - 804   2017.06( ISSN:0925-5710

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    DOI: 10.1007/s12185-017-2208-2

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  • Reduced- intensity conditioning allogeneic hematopoietic cell transplantation for younger patients with acute myeloid leukemia: a registry- based study Reviewed

    Yanada M., Kurosawa S., Kobayashi T., Ozawa Y., Kanamori H., Kobayashi N., Sawa M., Nakamae H., Uchida N., Hashimoto H., Fukuda T., Hirokawa M., Atsuta Y., Yano S.

    BONE MARROW TRANSPLANTATION   52 ( 6 )   818 - 824   2017.06( ISSN:0268-3369

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    DOI: 10.1038/bmt.2016.358

  • Immunoprofile Changes during Dasatinib Treatment in Patients with Chronic Myeloid Leukemia: A Prospective Observational Study(和訳中) Reviewed

    Kuno Masatomo, Nakane Takahiko, Katayama Takako, Koh Hideo, Nakashima Yasuhiro, Nishimoto Mitsutaka, Nakamae Mika, Hirose Asao, Hino Masayuki, Nakamae Hirohisa

    大阪市医学会 Osaka City Medical Journal   63 ( 1 )   43 - 55   2017.06( ISSN:0030-6096

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  • 日本人の新規診断慢性期慢性骨髄性白血病に対するダサチニブとイマチニブの比較 DASISION試験から5年後の最終報告のサブ解析(Dasatinib versus imatinib in Japanese patients with newly diagnosed chronic phase chronic myeloid leukemia: a subanalysis of the DASISION 5-year final report) Reviewed

    Nakamae Hirohisa, Fujisawa Shin, Ogura Michinori, Uchida Toshiki, Onishi Yasushi, Taniwaki Masafumi, Utsunomiya Atae, Matsue Kosei, Takamatsu Yasushi, Usuki Kensuke, Tanimoto Mitsune, Ishida Yoji, Ohashi Kazuteru, Li Li, Miyoshi Masafumi

    (一社)日本血液学会 International Journal of Hematology   105 ( 6 )   792 - 804   2017.06( ISSN:0925-5710

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    慢性骨髄性白血病(CML-CP)患者におけるダサチニブ(DA)とイマチニブ(IM)の有効性と安全性をDASISION試験の成績をもとに検討した。日本人患者に限定した場合の両剤の比較と、日本人と全被験者の比較を行った。DA 100mg/日投与群は259例、IM 400mg投与群は260例で、日本人は49例(DA群26例、IM群23例)であった。検討の結果、日本人患者で試験終了時に被験薬を継続していたのは、DA群が20例(77%)、IM群が14例(61%)であった。細胞遺伝学的完全寛解が得られたのはDA群が96%、IM群が87%、分子遺伝学的効果が得られたのはDA群が88%、IM群が74%であった。試験開始から3ヵ月後にBCR-ABLI 10%以下を達成していた患者では、5年無増悪生存率はDA群が96%、IM群が88%、全生存率はDA群が96%、IM群が100%であった。また、グレード3/4の非血液毒性の発現は日本人患者、全被験者ともに少なく、胸水の発現率は日本人DA群(42%)の方が、日本人IM群(4%)および全被験者DA群(28%)よりも高値であった。日本人CML-CP患者に対するDAの安全性と有効性はIMとほぼ同等であることが示された。

  • Pericarditis Associated With Human Herpesvirus-6 Reactivation in a Patient After Unrelated Cord Blood Transplant Reviewed

    Yoshida Masahiro, Nakamae Hirohisa, Okamura Hiroshi, Nishimoto Mitsutaka, Hayashi Yoshiki, Koh Hideo, Nakane Takahiko, Hino Masayuki

    EXPERIMENTAL AND CLINICAL TRANSPLANTATION   15 ( 2 )   235 - 238   2017.04( ISSN:1304-0855

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    DOI: 10.6002/ect.2014.0261

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  • Use of mycophenolate mofetil and a calcineurin inhibitor in allogeneic hematopoietic stem-cell transplantation from HLA-matched siblings or unrelated volunteer donors: Japanese multicenter phase II trials Reviewed

    Nakane Takahiko, Nakamae Hirohisa, Yamaguchi Takuhiro, Kurosawa Saiko, Okamura Atsuo, Hidaka Michihiro, Fuji Shigeo, Kohno Akio, Saito Takeshi, Aoyama Yasutaka, Hatanaka Kazuo, Katayama Yoshio, Yakushijin Kimikazu, Matsui Toshimitsu, Yamamori Motohiro, Takami Akiyoshi, Hino Masayuki, Fukuda Takahiro

    INTERNATIONAL JOURNAL OF HEMATOLOGY   105 ( 4 )   485 - 496   2017.04( ISSN:0925-5710

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    DOI: 10.1007/s12185-016-2154-4

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  • HLA適合血縁者および非血縁ボランティアドナーからの同種造血幹細胞移植におけるミコフェノール酸モフェチルおよびカルシニューリン阻害剤の使用 日本における多施設第II相試験(Use of mycophenolate mofetil and a calcineurin inhibitor in allogeneic hematopoietic stem-cell transplantation from HLA-matched siblings or unrelated volunteer donors: Japanese multicenter phase II trials) Reviewed

    Nakane Takahiko, Nakamae Hirohisa, Yamaguchi Takuhiro, Kurosawa Saiko, Okamura Atsuo, Hidaka Michihiro, Fuji Shigeo, Kohno Akio, Saito Takeshi, Aoyama Yasutaka, Hatanaka Kazuo, Katayama Yoshio, Yakushijin Kimikazu, Matsui Toshimitsu, Yamamori Motohiro, Takami Akiyoshi, Hino Masayuki, Fukuda Takahiro

    (一社)日本血液学会 International Journal of Hematology   105 ( 4 )   485 - 496   2017.04( ISSN:0925-5710

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    HLA適合血縁ドナー(MRD)および非血縁ドナー(HRD)からの同種造血幹細胞移植(HSCT)を実施し、移植片対宿主病(GVHD)予防におけるミコフェノール酸モフェチル(MMF)とカルシニューリン阻害剤(CNI)の実施可能性、ならびにミコフェノール酸(MPA)レベルとGVHDとの関連を調べる2つの多施設前向き第II相試験を実施した。対象はMRD群20例(男性8例、女性12例、年齢中央値47歳、MMFおよびシクロスポリン)、URD群31例(男性17例、女性14例、年齢中央値45歳、MMFおよびタクロリムス)とした。第100日における急性GVHDグレードII〜IVの累積発現率は、MRD群で45.0%、URD群で25.8%であった。3年生存率はMRD群で80.0%、URD群で74.2%であった。非再発死亡率はMRD群で15.0%、URD群で6.5%であった。MMFによるGVHD予防は、メトトレキサートと比較して重症粘膜炎の発現頻度が低く、好中球生着が迅速であった。薬物動態試験では、MPA血漿濃度高値と急性GVHD発現頻度低値との間に関連が認められた。

  • Outcome differences between children and adolescents and young adults with non-Hodgkin lymphoma following stem cell transplantation Reviewed

    Kobayashi Ryoji, Mitsui Tetsuo, Fujita Naoto, Osumi Tomoo, Aoki Tomohiro, Aoki Kazunari, Suzuki Ritsuro, Fukuda Takahiro, Miyamoto Toshihiro, Kato Koji, Nakamae Hirohisa, Goto Hiroaki, Eto Tetsuya, Inoue Masami, Mori Takehiko, Terui Kiminori, Onizuka Masahito, Koh Katsuyoshi, Koga Yuhki, Ichinohe Tatsuo, Sawada Akihisa, Atsuta Yoshiko, Suzumiya Junji

    INTERNATIONAL JOURNAL OF HEMATOLOGY   105 ( 3 )   369 - 376   2017.03( ISSN:0925-5710

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    DOI: 10.1007/s12185-016-2120-1

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  • 幹細胞移植後の非ホジキンリンパ腫の小児および思春期・若年成人における治療成績の差(Outcome differences between children and adolescents and young adults with non-Hodgkin lymphoma following stem cell transplantation) Reviewed

    Kobayashi Ryoji, Mitsui Tetsuo, Fujita Naoto, Osumi Tomoo, Aoki Tomohiro, Aoki Kazunari, Suzuki Ritsuro, Fukuda Takahiro, Miyamoto Toshihiro, Kato Koji, Nakamae Hirohisa, Goto Hiroaki, Eto Tetsuya, Inoue Masami, Mori Takehiko, Terui Kiminori, Onizuka Masahito, Koh Katsuyoshi, Koga Yuhki, Ichinohe Tatsuo, Sawada Akihisa, Atsuta Yoshiko, Suzumiya Junji

    (一社)日本血液学会 International Journal of Hematology   105 ( 3 )   369 - 376   2017.03( ISSN:0925-5710

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    移植登録一元管理プログラム(TRUMP)システムのデータを用いて、1995〜2013年に幹細胞移植(SCT)を施行された30歳以下の非ホジキンリンパ腫(NHL)患者918例(男性593例、女性325例、年齢中央値21歳)の治療成績を解析した。0〜15歳を小児、16〜30歳を思春期・若年成人(AYA世代)とした。同種移植患者において、生存率、無再発生存率、再発率、移植関連死亡率は小児患者とAYA世代の患者間で有意差はなかった。しかし、自己移植患者における5年移植関連死亡率はAYA世代よりも小児で有意に高かった(小児5.1%、AYA世代0.8%、P=0.0043)。AYA世代のNHL患者における移植成績は小児と比較して劣っていないことが明らかになった。

  • Cidofovir Treatment for Adenovirus-Associated Hemorrhagic Cystitis in Adult Recipients of Allogeneic Hematopoietic Stem Cell Transplantation: A Retrospective Comparative Study Reviewed

    Yoshimura Takuro, Nishimoto Mitsutaka, Nakane Takahiko, Koh Hideo, Nakashima Yasuhiro, Takeoka Yasunobu, Nakamae Mika, Hirose Asao, Hino Masayuki, Nakamae Hirohisa

    BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION   23 ( 3 )   S191 - S191   2017.03( ISSN:1083-8791

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  • Low-dose thymoglobulin as second-line treatment for steroid-resistant acute GvHD: an analysis of the JSHCT Reviewed

    Murata M., Ikegame K., Morishita Y., Ogawa H., Kaida K., Nakamae H., Ikeda T., Nishida T., Inoue M., Eto T., Kubo K., Sakura T., Mori T., Uchida N., Ashida T., Matsuhashi Y., Miyazaki Y., Ichinohe T., Atsuta Y., Teshima T.

    BONE MARROW TRANSPLANTATION   52 ( 2 )   252 - 257   2017.02( ISSN:0268-3369

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    DOI: 10.1038/bmt.2016.247

  • Outcomes of Allogeneic Hematopoietic Stem Cell Transplantation in Adult Patients with Myelodysplastic Syndrome Harboring Trisomy 8 Reviewed

    Konuma Takaaki, Miyazaki Yasushi, Uchida Naoyuki, Ohashi Kazuteru, Kondo Tadakazu, Nakamae Hirohisa, Takahashi Satoshi, Mori Takehiko, Ozawa Yukiyasu, Kato Chiaki, Iwato Koji, Fukuda Takahiro, Ichinohe Tatsuo, Atsuta Yoshiko, Ishiyama Ken

    BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION   23 ( 1 )   75 - 80   2017.01( ISSN:1083-8791

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    DOI: 10.1016/j.bbmt.2016.10.015

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  • An Elderly Woman with Anti-neutrophil Antibody-positive Agranulocytosis Who Responded to High-dose Intravenous Methylprednisolone Reviewed

    Koh Shiro, Koh Hideo, Kubo Yuki, Kuroda Maiko, Nishimoto Mitsutaka, Yoshimura Takuro, Nakashima Yasuhiro, Nakane Takahiko, Nakamae Hirohisa, Ohsawa Masahiko, Hino Masayuki

    一般社団法人 日本内科学会 INTERNAL MEDICINE   56 ( 16 )   2199 - 2203   2017( ISSN:0918-2918

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    <p>Although anti-neutrophil antibodies (ANAs) often exist and immunoreaction may be involved in agranulocytosis, few reports have so far described ANA-positive cases of agranulocytosis with an unknown etiology. We herein describe the case of a 69-year-old woman who presented with ANA-positive agranulocytosis. In this case, both the withdrawal of the drugs that had possibly caused neutropenia and the use of granulocyte-colony stimulating factor (G-CSF) were ineffective treatment measures. Approximately 2 weeks after the discontinuation of the suspected drugs, we initiated corticosteroid pulse therapy; the neutrophil count recovered by day 19 of steroid therapy. High-dose methylprednisolone therapy should thus be considered for patients demonstrating ANA-positive agranulocytosis with an unknown etiology that is refractory to G-CSF treatment. </p>

    DOI: 10.2169/internalmedicine.8268-16

    PubMed

    CiNii Article

  • Diagnostic usefulness of plasma presepsin (soluble CD14-subtype) for diagnosing hemophagocytic syndrome in hematological malignancies Reviewed

    Koh Hideo, Nanno Satoru, Katayama Takako, Hirose Asao, Nakamae Mika, Hino Masayuki, Nakamae Hirohisa

    LEUKEMIA & LYMPHOMA   58 ( 10 )   2489 - 2492   2017( ISSN:1042-8194

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    DOI: 10.1080/10428194.2017.1292356

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  • Diagnostic value of serum ferritin and the risk factors and cytokine profiles of hemophagocytic syndrome following allogeneic hematopoietic cell transplantation Reviewed

    Nanno Satoru, Koh Hideo, Nakashima Yasuhiro, Katayama Takako, Okamura Hiroshi, Koh Shiro, Yoshimura Takuro, Nishimoto Mitsutaka, Hayashi Yoshiki, Nakamae Mika, Hirose Asao, Nakane Takahiko, Hino Masayuki, Nakamae Hirohisa

    LEUKEMIA & LYMPHOMA   58 ( 7 )   1664 - 1672   2017( ISSN:1042-8194

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    DOI: 10.1080/10428194.2016.1262034

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  • Dasatinib and Prednisolone Induction Therapy for a Case of Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia with Dilated Cardiomyopathy Accompanied by Life-Threatening Ventricular Tachycardia Reviewed

    Nishimoto Mitsutaka, Nakamae Hirohisa, Matsumoto Kana, Morita Kunihiko, Koga Yuki, Momose Dai, Hino Masayuki

    CASE REPORTS IN HEMATOLOGY   2017   4027908   2017( ISSN:2090-6560

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    DOI: 10.1155/2017/4027908

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  • Prophylactic Use of a Combination of an Anticoagulant and Ursodeoxycholic Acid for Sinusoidal Obstruction Syndrome after Allogeneic Myeloablative Hematopoietic Stem Cell Transplantation Reviewed

    Okamura Hiroshi, Nishimoto Mitsutaka, Nakane Takahiko, Koh Hideo, Nakashima Yasuhiro, Takeoka Yasunobu, Nakamae Mika, Hirose Asao, Hino Masayuki, Nakamae Hirohisa

    BLOOD   128 ( 22 )   2016.12( ISSN:0006-4971

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  • Allogeneic Hematopoietic Cell Transplantation for Leukemic Transformation Preceded by Philadelphia Chromosome Negative Myeloproliferative Neoplasms: A Nationwide Survey by the Adult Acute Myeloid Leukemia Working Group of the Japan Society for Hematopoietic Cell Transplantation Reviewed

    Takagi Shinsuke, Masuoka Kazuhiro, Uchida Naoyuki, Kurokawa Mineo, Nakamae Hirohisa, Imada Kazunori, Iwato Koji, Ichinohe Tatsuo, Atsuta Yoshiko, Takami Akiyoshi, Yano Shingo

    BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION   22 ( 12 )   2208 - 2213   2016.12( ISSN:1083-8791

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    DOI: 10.1016/j.bbmt.2016.09.017

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  • CXCL1-Chemokine (C-X-C Motif) Receptor 2 Signaling Stimulates the Recruitment of Bone Marrow-Derived Mesenchymal Cells into Diffuse-Type Gastric Cancer Stroma Reviewed

    Kasashima Hiroaki, Yashiro Masakazu, Nakamae Hirohisa, Kitayama Kisyu, Masuda Go, Kinoshita Haruhito, Fukuoka Tatsunari, Hasegawa Tsuyoshi, Nakane Takahiko, Hino Masayuki, Hirakawa Kosei, Ohira Masaichi

    AMERICAN JOURNAL OF PATHOLOGY   186 ( 11 )   3028 - 3039   2016.11( ISSN:0002-9440

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    DOI: 10.1016/j.ajpath.2016.07.024

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  • An Open-labeled, Multicenter Phase II Study of Tamibarotene in Patients with Steroid-refractory Chronic Graft-versus-Host Disease Reviewed

    Maeda Yoshinobu, Nishimori Hisakazu, Inamoto Yoshihiro, Nakamae Hirohisa, Sawa Masashi, Mori Yasuo, Ohashi Kazuteru, Fujiwara Shin-Ichiro, Tanimoto Mitsune

    ACTA MEDICA OKAYAMA   70 ( 5 )   409 - 412   2016.10( ISSN:0386-300X

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  • An Open-labeled, Multicenter Phase II Study of Tamibarotene in Patients with Steroid-refractory Chronic Graft-versus-Host Disease. Reviewed

    Maeda Y, Nishimori H, Inamoto Y, Nakamae H, Sawa M, Mori Y, Ohashi K, Fujiwara SI, Tanimoto M

    Acta medica Okayama   70 ( 5 )   409 - 412   2016.10( ISSN:0386-300X

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    DOI: 10.18926/AMO/54603

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  • 発熱を伴う好中球減少症患者の細菌同定に対する23SリボソームRNA遺伝子を標的とするin situハイブリダイゼーションと血液培養との組み合わせアプローチ(Combinational approach using in situ hybridization targeting 23S ribosomal RNA genes and blood cultures for bacterial identification in patients with neutropenia and fever) Reviewed

    Koh Hideo, Aimoto Mizuki, Matsuhisa Akio, Inoue Shin-ichi, Katayama Takako, Okamura Hiroshi, Yoshimura Takuro, Koh Shiro, Nanno Satoru, Nishimoto Mitsutaka, Nakashima Yasuhiro, Hirose Asao, Nakamae Mika, Nakane Takahiko, Hino Masayuki, Nakamae Hirohisa

    エルゼビア・ジャパン(株) Journal of Infection and Chemotherapy   22 ( 9-10 )   697 - 703   2016.10( ISSN:1341-321X

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    化学療法施行中の発熱性好中球減少症(FN)患者において、global bacteria probe(GBプローブ)を用いた新たなin situハイブリダイゼーション法(ISH)の有用性を評価した。患者34例(男18例、女16例、年齢中央値42.5歳)を対象とした。50回の発熱事象を評価した。発熱時におけるISHによる原因菌の特定は原因不明の発熱事象24で21%、局所感染(血液培養陰性)による発熱事象15で13%であった。敗血症7名(血液培養陽性)では発熱時にISH陽性に達したのは71%であった。好中球数0/μLと171/μLの症例では陰性の結果が得られた。この新しいISH法は、化学療法後に好中球減少症と原因不明の発熱を有する血液培養陰性患者における、細菌の早期検出に有用であった。この方法と血液培養との併用は好中球数が極端に低い症例においてでも、FNの良好な管理に寄与する可能性があると考えられた。

  • Prognostic Effect of Low Subcutaneous Adipose Tissue on Survival Outcome in Patients With Multiple Myeloma Reviewed

    Takeoka Yasunobu, Sakatoku Kazuki, Miura Akiko, Yamamura Ryosuke, Araki Taku, Seura Hirotaka, Okamura Terue, Koh Hideo, Nakamae Hirohisa, Hino Masayuki, Ohta Kensuke

    CLINICAL LYMPHOMA MYELOMA & LEUKEMIA   16 ( 8 )   434 - 441   2016.08( ISSN:2152-2650

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    DOI: 10.1016/j.clml.2016.04.010

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  • Disseminated Hormographiella aspergillata infection with involvement of the lung, brain, and small intestine following allogeneic hematopoietic stem cell transplantation: case report and literature review Reviewed

    Nanno S., Nakane T., Okamura H., Nishimoto M., Koh H., Nakamae H., Ohsawa M., Yarita K., Kamei K., Hino M.

    TRANSPLANT INFECTIOUS DISEASE   18 ( 4 )   611 - 616   2016.08( ISSN:1398-2273

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    DOI: 10.1111/tid.12561

  • 慢性移植片対宿主病に関連する多発性筋炎におけるTh1、Th2、Th17サイトカインの血漿中動態(Plasma Kinetics of Th1, Th2 and Th17 Cytokines in Polymyositis Related to Chronic Graft-versus-Host Disease) Reviewed

    Koh Shiro, Koh Hideo, Nakashima Yasuhiro, Katayama Takako, Sakabe Manami, Okamura Hiroshi, Yoshimura Takuro, Nanno Satoru, Nishimoto Mitsutaka, Hayashi Yoshiki, Nakane Takahiko, Nakamae Hirohisa, Ohsawa Masahiko, Hino Masayuki

    (一社)日本内科学会 Internal Medicine   55 ( 16 )   2265 - 2270   2016.08( ISSN:0918-2918

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    症例は36歳男性で、骨髄異形成症候群のため同種造血細胞移植(allo-HCT)を施行されたが、25日後にグレード3の急性移植片対宿主病(GVHD)を発症した。メチルプレドニゾロン投与により症状は消失したが、allo-HCTから1570日後に机の角に右大腿をぶつけてしまった。大腿が腫脹した後、全身疲労と高熱が出現し、筋肉痛のため歩行不能になったため入院した。筋生検で筋線維の破壊およびCD20陽性B細胞とCD4陽性・CD8陽性T細胞の浸潤が明らかとなり、肝生検では慢性GVHDの所見が確認された。血漿サイトカインプロファイル分析で、Tヘルパー(Th)1およびTh2だけでなくTh17サイトカインの上昇を認めた。プレドニゾロン経口投与により症状は消失した。

  • 血液疾患患者の発熱性好中球減少症におけるプレセプシン(可溶性CD14サブタイプ)レベルの診断的価値(Diagnostic value of levels of presepsin(soluble CD14-subtype) in febrile neutropenia in patients with hematological disorders) Reviewed

    Koh Hideo, Aimoto Mizuki, Katayama Takako, Hashiba Masamichi, Sato Ayumi, Kuno Masatomo, Makuuchi Yosuke, Takakuwa Teruto, Okamura Hiroshi, Hirose Asao, Nakamae Mika, Hino Masayuki, Nakamae Hirohisa

    エルゼビア・ジャパン(株) Journal of Infection and Chemotherapy   22 ( 7-8 )   466 - 471   2016.08( ISSN:1341-321X

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    血液疾患に対する化学療法により発熱性好中球減少症(FN)を発症した患者43名(男13名、平均45歳、75エピソード:コホート1)および患者4名(男1名、平均46歳、4エピソード:コホート2)を対象とするプロスペクティブ観察研究を行った。2010年11月〜2012年2月までのサンプルを用いたコホート1にて、プレセプシンとプロカルシトニンの有用性を比較し、2013年11月〜2014年1月までのサンプルを用いたコホート2にて、プロカルシトニン、C反応性タンパク質などとプレセプシンを比較した。その結果、コホート1においてFN発症時の血清プレセプシンは化学療法前と比べて有意に高値であった(P=0.004)。不明熱、局所感染、菌血症および敗血症性ショックにおけるFN発症72時間以内の血清プレセプシンの中央値はそれぞれ、680、763、782、1359pg/mL(基準値314pg/mL)であった。散布図にてプレセプシン値≧500pg/ml、プロカルシトニン値<0.50ng/mlであった。コホート2において、感染が特定されない2例ではFN発症から72時後までの血漿プレセプシンの平均値(175と131pg/mL)が陰性に、臨床的に感染がある2例(346と329pg/mL)では陽性に分類され、プロカルシトニン、C反応性タンパク質値などと相関が見られた。プレセプシンはFNにおける細菌感染を早期に高感度に診断できる指標であると考えられた。

  • 血液悪性腫瘍における血球貪食症候群の新規予後予測マーカーとしての血漿プレセプシン(可溶性CD14サブタイプ)(Plasma Levels of Presepsin(Soluble CD14-subtype) as a Novel Prognostic Marker for Hemophagocytic Syndrome in Hematological Malignancies) Reviewed

    Nanno Satoru, Koh Hideo, Katayama Takako, Hashiba Masamichi, Sato Ayumi, Makuuchi Yosuke, Nagasaki Joji, Kuno Masatomo, Yoshimura Takuro, Okamura Hiroshi, Nishimoto Mitsutaka, Hirose Asao, Nakamae Mika, Nakane Takahiko, Hino Masayuki, Nakamae Hirohisa

    (一社)日本内科学会 Internal Medicine   55 ( 16 )   2173 - 2184   2016.08( ISSN:0918-2918

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    2006年4月〜2014年8月に当院で血球貪食症候群(HPS)と診断した血液悪性腫瘍患者のうち、血液検体が利用可能な14例(男性9例、女性5例、年齢22〜65歳)を後ろ向きに調査し、血清プレセプシンが新規の予後予測マーカーとなりうるか検討した。また、血清プレセプシンと可溶性インターロイキン(IL)-2受容体(sIL-2R)、フェリチン、腫瘍壊死因子-α(TNF-α)、インターフェロン-γ(IFN-γ)、IL-6、IL-10を組み合わせた複合マーカーについても検討した。単変量Coxモデルでは、いずれの因子もHPSの予後および治療反応性との間に有意な関連を認めなかった。しかし、HPS発症時の検体が利用可能であった12例では、HPS発症時にプレセプシン(>1935pg/mL)とsIL-2R(>4585U/mL)の両方が上昇している患者では有意に死亡率が高く、治療反応性も低かった。以上から、HPS発症時の血漿プレプセシンと血清sIL-2Rの両方の高値は、血液悪性腫瘍にHPSを続発した患者における新規予後予測因子となる可能性が示唆された。

  • Lung function score including a parameter of small airway disease as a highly predictive indicator of survival after allogeneic hematopoietic cell transplantation Reviewed

    Nakamae Mika, Yamashita Mariko, Koh Hideo, Nishimoto Mitsutaka, Hayashi Yoshiki, Nakane Takahiko, Nakashima Yasuhiro, Hirose Asao, Hino Masayuki, Nakamae Hirohisa

    TRANSPLANT INTERNATIONAL   29 ( 6 )   707 - 714   2016.06( ISSN:0934-0874

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    DOI: 10.1111/tri.12779

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  • THE ALTERATION OF IMMUNOPROFILE DURING DASATINIB TREATMENT IN PATIENTS WITH CHRONIC MYELOID LEUKEMIA: A PROSPECTIVE OBSERVATIONAL STUDY Reviewed

    Kuno M., Nakamae H., Katayama T., Nishimoto M., Hayashi Y., Hirose A., Nakamae M., Nakashima Y., Koh H., Nakane T., Hino M.

    HAEMATOLOGICA   101   457 - 457   2016.06( ISSN:0390-6078

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  • Validation of a rapid one-step high sensitivity real-time quantitative PCR system for detecting major BCR-ABL1 mRNA on an International Scale Reviewed

    Yoshida Chikashi, Nakamae Hirohisa, Fletcher Linda, Koga Daisuke, Sogabe Takayuki, Matsumura Itaru, Kanakura Yuzuru, Branford Susan, Naoe Tomoki

    SPRINGERPLUS   5   569   2016.05( ISSN:2193-1801

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    DOI: 10.1186/s40064-016-2258-6

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  • Long-term benefits and risks of frontline nilotinib vs imatinib for chronic myeloid leukemia in chronic phase: 5-year update of the randomized ENESTnd trial Reviewed

    Hochhaus A., Saglio G., Hughes T. P., Larson R. A., Kim D-W, Issaragrisil S., le Coutre P. D., Etienne G., Dorlhiac-Llacer P. E., Clark R. E., Flinn I. W., Nakamae H., Donohue B., Deng W., Dalal D., Menssen H. D., Kantarjian H. M.

    LEUKEMIA   30 ( 5 )   1044 - 1054   2016.05( ISSN:0887-6924

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    DOI: 10.1038/leu.2016.5

  • A prospective multicenter study of unrelated bone marrow transplants using a reduced-intensity conditioning regimen with low-dose ATG-F Reviewed

    Fuji S., Kim S-W, Yano S., Hagiwara S., Nakamae H., Hidaka M., Ito T., Ohashi K., Hatanaka K., Takami A., Kurosawa S., Yamashita T., Yamaguchi T., Fukuda T.

    BONE MARROW TRANSPLANTATION   51 ( 3 )   451 - 453   2016.03( ISSN:0268-3369

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    DOI: 10.1038/bmt.2015.268

  • Influence of Differently Licensed KIR2DL1-Positive Natural Killer Cells in Transplant Recipients with Acute Leukemia: A Japanese National Registry Study Reviewed

    Arima Nobuyoshi, Nakamura Fumiaki, Yabe Toshio, Tanaka Junji, Fuji Shigeo, Ohashi Kazuteru, Fukuda Takahiro, Miyamura Koichi, Iwato Koji, Eto Tetsuya, Mori Takehiko, Kobayashi Naoki, Hoshino Takumi, Kato Chiaki, Kanamori Heiwa, Nakamae Hirohisa, Atsuta Yoshiko, Morishima Yasuo, Kanda Yoshinobu

    BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION   22 ( 3 )   423 - 431   2016.03( ISSN:1083-8791

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    DOI: 10.1016/j.bbmt.2015.09.029

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  • Impact of MRD and TKI on allogeneic hematopoietic cell transplantation for Ph plus ALL: a study from the adult ALL WG of the JSHCT Reviewed

    Nishiwaki S., Imai K., Mizuta S., Kanamori H., Ohashi K., Fukuda T., Onishi Y., Takahashi S., Uchida N., Eto T., Nakamae H., Yujiri T., Mori S., Nagamura-Inoue T., Suzuki R., Atsuta Y., Tanaka J.

    BONE MARROW TRANSPLANTATION   51 ( 1 )   43 - 50   2016.01( ISSN:0268-3369

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    DOI: 10.1038/bmt.2015.217

  • Risk factors and prognosis of hepatic acute GvHD after allogeneic hematopoietic cell transplantation Reviewed

    Arai Y., Kanda J., Nakasone H., Kondo T., Uchida N., Fukuda T., Ohashi K., Kaida K., Iwato K., Eto T., Kanda Y., Nakamae H., Nagamura-Inoue T., Morishima Y., Hirokawa M., Atsuta Y., Murata M.

    BONE MARROW TRANSPLANTATION   51 ( 1 )   96 - 102   2016.01( ISSN:0268-3369

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    DOI: 10.1038/bmt.2015.205

  • Combinational approach using in situ hybridization targeting 23S ribosomal RNA genes and blood cultures for bacterial identification in patients with neutropenia and fever Reviewed

    Koh Hideo, Aimoto Mizuki, Matsuhisa Akio, Inoue Shin-Ichi, Katayama Takako, Okamura Hiroshi, Yoshimura Takuro, Koh Shiro, Nanno Satoru, Nishimoto Mitsutaka, Nakashima Yasuhiro, Hirose Asao, Nakamae Mika, Nakane Takahiko, Hino Masayuki, Nakamae Hirohisa

    JOURNAL OF INFECTION AND CHEMOTHERAPY   22 ( 9-10 )   697 - 703   2016( ISSN:1341-321X

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    DOI: 10.1016/j.jiac.2016.08.001

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  • Plasma Levels of Presepsin (Soluble CD14-subtype) as a Novel Prognostic Marker for Hemophagocytic Syndrome in Hematological Malignancies Reviewed

    Nanno Satoru, Koh Hideo, Katayama Takako, Hashiba Masamichi, Sato Ayumi, Makuuchi Yosuke, Nagasaki Joji, Kuno Masatomo, Yoshimura Takuro, Okamura Hiroshi, Nishimoto Mitsutaka, Hirose Asao, Nakamae Mika, Nakane Takahiko, Hino Masayuki, Nakamae Hirohisa

    一般社団法人 日本内科学会 INTERNAL MEDICINE   55 ( 16 )   2173 - 2184   2016( ISSN:0918-2918

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    <p><b>Objective </b>Recent studies suggest that presepsin (soluble CD14-subtype) is a useful diagnostic and prognostic marker for sepsis, with secretion by activated macrophages potentially dependent on phagocytosis of microorganisms. As "hemophagocytosis" is one of the major characteristics in patients with hemophagocytic syndrome (HPS), we hypothesized that presepsin may reflect the phagocytic activity and be a useful prognostic marker for HPS. Therefore, we aimed to assess the prognostic potential of presepsin in secondary HPS in adult patients with hematological malignancies. </p><p><b>Methods </b>Between April 2006 and August 2014, we retrospectively examined consecutive patients with HPS whose blood samples were available at our institution and compared the prognostic value of the following in HPS, singly and in combination: plasma presepsin, serum soluble interleukin (IL)-2 receptor (sIL-2R), ferritin, tumor necrosis factor-α (TNF-α), interferon-γ (IFN-γ), IL-6 and IL-10. </p><p><b>Results </b>A total of 14 patients were enrolled. The median age of the patients was 46.5 years (range, 22-65). In univariable Cox models, there were no significant variables associated with the prognosis. However, in 12 evaluable patients, only the combination of higher median values of presepsin (>1,935 pg/mL) and sIL-2R (>4,585 U/mL) at the onset of HPS was significantly associated with the 90-day mortality (hazard ratio 14.5; 95% CI, 1.47-143.36; p=0.02). </p><p><b>Conclusion </b>These results suggest that a composite model of plasma presepsin and serum sIL-2R levels at the onset of HPS might be a novel predictor of the prognosis of patients with hematological malignancies and secondary HPS. </p>

    DOI: 10.2169/internalmedicine.55.6524

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    CiNii Article

  • Plasma Kinetics of Th1, Th2 and Th17 Cytokines in Polymyositis Related to Chronic Graft-versus-Host Disease Reviewed

    Koh Shiro, Koh Hideo, Nakashima Yasuhiro, Katayama Takako, Sakabe Manami, Okamura Hiroshi, Yoshimura Takuro, Nanno Satoru, Nishimoto Mitsutaka, Hayashi Yoshiki, Nakane Takahiko, Nakamae Hirohisa, Ohsawa Masahiko, Hino Masayuki

    一般社団法人 日本内科学会 INTERNAL MEDICINE   55 ( 16 )   2265 - 2270   2016( ISSN:0918-2918

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    <p>We herein describe a case of myelodysplastic syndrome with chronic graft-versus-host disease (cGVHD)-related polymyositis. On approximately day 1,570 post HLA-identical sibling bone marrow transplant, the patient presented with a fever, myalgia and liver dysfunction. A muscle biopsy revealed destruction of the muscle fibers and infiltration of CD20<sup>+</sup> B cells and CD4<sup>+</sup> and CD8<sup>+</sup> T cells, and a liver biopsy confirmed the findings of cGVHD. An analysis of plasma cytokine profiles indicated elevation of not only T-helper (Th)1 and Th2, but also Th17 cytokines. Increases in these cytokines in addition to the invasion of inflammatory cells might be associated with the pathophysiology of cGVHD involving the muscle and liver. </p>

    DOI: 10.2169/internalmedicine.55.6206

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  • Diagnostic value of levels of presepsin (soluble CD14-subtype) in febrile neutropenia in patients with hematological disorders Reviewed

    Koh Hideo, Aimoto Mizuki, Katayama Takako, Hashiba Masamichi, Sato Ayumi, Kuno Masatomo, Makuuchi Yosuke, Takakuwa Teruto, Okamura Hiroshi, Hirose Asao, Nakamae Mika, Hino Masayuki, Nakamae Hirohisa

    JOURNAL OF INFECTION AND CHEMOTHERAPY   22 ( 7-8 )   466 - 471   2016( ISSN:1341-321X

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    DOI: 10.1016/j.jiac.2016.04.002

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  • Efficacy and safety of intra-arterial steroid infusions in patients with steroid-resistant gastrointestinal acute graft-versus-host disease Reviewed

    Nishimoto Mitsutaka, Koh Hideo, Hirose Asao, Nakamae Mika, Nakane Takahiko, Hayashi Yoshiki, Okamura Hiroshi, Yoshimura Takuro, Koh Shiro, Nanno Satoru, Nakashima Yasuhiro, Takeshita Toru, Yamamoto Akira, Sakai Yukimasa, Nishida Norifumi, Matsuoka Toshiyuki, Miki Yukio, Hino Masayuki, Nakamae Hirohisa

    EXPERIMENTAL HEMATOLOGY   43 ( 12 )   995 - 1000   2015.12( ISSN:0301-472X

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    DOI: 10.1016/j.exphem.2015.08.002

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  • Discontinuation of dasatinib in patients with chronic myeloid leukaemia who have maintained deep molecular response for longer than 1 year (DADI trial): a multicentre phase 2 trial Reviewed

    Imagawa Jun, Tanaka Hideo, Okada Masaya, Nakamae Hirohisa, Hino Masayuki, Murai Kazunori, Ishida Yoji, Kumagai Takashi, Sato Seiichi, Ohashi Kazuteru, Sakamaki Hisashi, Wakita Hisashi, Uoshima Nobuhiko, Nakagawa Yasunori, Minami Yosuke, Ogasawara Masahiro, Takeoka Tomoharu, Akasaka Hiroshi, Utsumi Takahiko, Uike Naokuni, Sato Tsutomu, Ando Sachiko, Usuki Kensuke, Morita Satoshi, Sakamoto Junichi, Kimura Shinya

    LANCET HAEMATOLOGY   2 ( 12 )   E528 - E535   2015.12( ISSN:2352-3026

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    DOI: 10.1016/S2352-3026(15)00196-9

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  • Cytomegalovirus Reactivation after Allogeneic Hematopoietic Stem Cell Transplantation is Associated with a Reduced Risk of Relapse in Patients with Acute Myeloid Leukemia Who Survived to Day 100 after Transplantation: The Japan Society for Hematopoietic Cell Transplantation Transplantation-related Complication Working Group Reviewed

    Takenaka Katsuto, Nishida Tetsuya, Asano-Mori Yuki, Oshima Kumi, Ohashi Kazuteru, Mori Takehiko, Kanamori Heiwa, Miyamura Koichi, Kato Chiaki, Kobayashi Naoki, Uchida Naoyuki, Nakamae Hirohisa, Ichinohe Tatsuo, Morishima Yasuo, Suzuki Ritsuro, Yamaguchi Takuhiro, Fukuda Takahiro

    BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION   21 ( 11 )   2008 - 2016   2015.11( ISSN:1083-8791

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    DOI: 10.1016/j.bbmt.2015.07.019

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  • HLA haploidentical peripheral blood stem cell transplantation using reduced dose of posttransplantation cyclophosphamide for poor-prognosis or refractory leukemia and myelodysplastic syndrome Reviewed

    Nakamae Hirohisa, Koh Hideo, Katayama Takako, Nishimoto Mitsutaka, Hayashi Yoshiki, Nakashima Yasuhiro, Nakane Takahiko, Nakamae Mika, Hirose Asao, Hino Masayuki

    EXPERIMENTAL HEMATOLOGY   43 ( 11 )   921 - 929   2015.11( ISSN:0301-472X

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    DOI: 10.1016/j.exphem.2015.07.006

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  • P0344-22-AM 同種造血幹細胞移植におけるカスポファンギンとカルシニューリン阻害剤併用時の薬物相互作用および安全性に関する検討(薬物相互作用,ポスター発表,一般演題,医療薬学の進歩と未来-次の四半世紀に向けて-) Reviewed

    徳和目 篤史, 西本 光孝, 高橋 正也, 中村 安孝, 康 秀男, 中前 博久, 西川 武司, 日野 雅之, 永山 勝也

    日本医療薬学会 日本医療薬学会年会講演要旨集   25   2015.10

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  • Effectiveness of antibacterial prophylaxis with non-absorbable polymyxin B compared to levofloxacin after allogeneic hematopoietic stem cell transplantation Reviewed

    Koh S., Yamada K., Nishimoto M., Hayashi Y., Koh H., Nakashima Y., Nakane T., Hirose A., Nakamae M., Kakeya H., Hino M., Nakamae H.

    TRANSPLANT INFECTIOUS DISEASE   17 ( 5 )   647 - 654   2015.10( ISSN:1398-2273

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    DOI: 10.1111/tid.12416

  • A new diagnostic kit, ODK-1201, for the quantitation of low major BCR-ABL mRNA level in chronic myeloid leukemia: correlation of quantitation with major BCR-ABL mRNA kits Reviewed

    Nakamae Hirohisa, Yoshida Chikashi, Miyata Yasuhiko, Hidaka Michihiro, Uike Naokuni, Koga Daisuke, Sogabe Takayuki, Matsumura Itaru, Kanakura Yuzuru, Naoe Tomoki

    INTERNATIONAL JOURNAL OF HEMATOLOGY   102 ( 3 )   304 - 311   2015.09( ISSN:0925-5710

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    DOI: 10.1007/s12185-015-1826-9

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  • Effect of Granulocyte Colony-Stimulating Factor-Combined Conditioning in Cord Blood Transplantation for Myelodysplastic Syndrome and Secondary Acute Myeloid Leukemia: A Retrospective Study in Japan Reviewed

    Konuma Takaaki, Takahashi Satoshi, Uchida Naoyuki, Kuwatsuka Yachiyo, Yamasaki Satoshi, Aoki Jun, Onishi Yasushi, Aotsuka Nobuyuki, Ohashi Kazuteru, Mori Takehiko, Masuko Masayoshi, Nakamae Hirohisa, Miyamura Kouichi, Kato Koji, Atsuta Yoshiko, Kato Seiko, Asano Shigetaka, Takami Akiyoshi, Miyazaki Yasushi

    BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION   21 ( 9 )   1632 - 1640   2015.09( ISSN:1083-8791

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    DOI: 10.1016/j.bbmt.2015.05.009

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  • 慢性骨髄性白血病における低major BCR-ABL mRNAを定量化するための新規診断キットODK-1201 major BCR-ABL mRNA測定キットによる定量との相関(A new diagnostic kit, ODK-1201, for the quantitation of low major BCR-ABL mRNA level in chronic myeloid leukemia: correlation of quantitation with major BCR-ABL mRNA kits) Reviewed

    Nakamae Hirohisa, Yoshida Chikashi, Miyata Yasuhiko, Hidaka Michihiro, Uike Naokuni, Koga Daisuke, Sogabe Takayuki, Matsumura Itaru, Kanakura Yuzuru, Naoe Tomoki

    (一社)日本血液学会 International Journal of Hematology   102 ( 3 )   304 - 311   2015.09( ISSN:0925-5710

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    慢性骨髄性白血病(CML)患者201例、非CML患者25例、健常者25例を対象に、major BCR-ABL mRNAの定量におけるODK-1201の性能を評価する多施設共同非盲検臨床試験を実施した。ODK-1201の最小検出感度は0.000619%であった。BCR-ABL mRNAの測定範囲は、ODK-1201の方が市販のCML用測定キット(Amp-CML)より広範囲であった。二つの測定値間の相関係数(r)は0.91であった。CML患者の試料224例におけるODK-1201とAmp-CML間の陽性一致率は99.2%であった。Amp-CMLで陰性と評価された92例のうち23例がODK-1201で陽性であり、両者の陰性一致率は75.0%であった。不一致例をIpsogenキットとMolecularMDキットで再評価したところ、全例で陽性と判明した。

  • Eosinophilic Crisisを呈する骨髄異形成症候群を合併した視神経炎(Optic Neuritis Associated with Myelodysplastic Syndrome Accompanied by Eosinophilic Crisis) Reviewed

    Nagasaki Joji, Nishimoto Mitsutaka, Nakamae Hirohisa, Nakane Takahiko, Koh Hideo, Yoshimoto Kumiko, Shiraki Kunihiko, Hino Masayuki

    (一社)日本内科学会 Internal Medicine   54 ( 17 )   2241 - 2244   2015.09( ISSN:0918-2918

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    症例は64歳男性で、主訴は発熱と疲労であった。末梢血では汎血球減少症が認められ、骨髄検査、形態学的検査、細胞遺伝学的検査から、骨髄異形成症候群(MDS)と確定診断した。MDSの治療計画を行ったが、患者が通院を中断してしまったため、実施することが出来なかった。しかし、3ヵ月後に右眼の視力障害を訴えて入院となり、両眼に軽度核白内障、右眼に相対性求心性瞳孔反応欠損が認められた。蛍光眼底撮影、細隙灯顕微鏡検査所見から、虚血性および非虚血性変化に起因する視神経炎と診断した。血液学的検査では汎血球減少症の改善と末梢血および骨髄で好酸球数の著増が認められたが、視神経炎に対してはメチルプレドニゾロンパルス療法を開始したところ、2週間以内に視神経乳頭浮腫が消失し、末梢血の好酸球数も急速に減少し、視野も部分的に改善が得られた。その後、低用量プレドニゾロンの維持療法が行われているが、視野欠損の悪化もみられず、11ヵ月間良好に維持されている。

  • Age influences post-graft-versus-host disease non-relapse mortality in adults with acute graft-versus-host disease of varying severity following allogeneic hematopoietic cell transplant Reviewed

    Nakane Takahiko, Fukuda Takahiro, Kanda Junya, Taniguchi Shuichi, Eto Tetsuya, Ohashi Kazuteru, Nakamae Hirohisa, Kurokawa Mineo, Mori Takehiko, Morishima Yasuo, Nagamura-Inoue Tokiko, Sakamaki Hisashi, Atsuta Yoshiko, Murata Makoto

    LEUKEMIA & LYMPHOMA   56 ( 8 )   2392 - 2397   2015.08( ISSN:1042-8194

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    DOI: 10.3109/10428194.2015.1009056

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  • Bone marrow-derived stromal cells are associated with gastric cancer progression Reviewed

    Kasashima H., Yashiro M., Nakamae H., Masuda G., Kinoshita H., Morisaki T., Fukuoka T., Hasegawa T., Sakurai K., Toyokawa T., Kubo N., Tanaka H., Muguruma K., Ohira M., Nakane T., Hino M., Hirakawa K.

    BRITISH JOURNAL OF CANCER   113 ( 3 )   443 - 452   2015.07( ISSN:0007-0920

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    DOI: 10.1038/bjc.2015.236

  • Efficiency of high-dose cytarabine added to CY/TBI in cord blood transplantation for myeloid malignancy Reviewed

    Arai Yasuyuki, Takeda June, Aoki Kazunari, Kondo Tadakazu, Takahashi Satoshi, Onishi Yasushi, Ozawa Yukiyasu, Aotsuka Nobuyuki, Kouzai Yasuji, Nakamae Hirohisa, Ota Shuichi, Nakaseko Chiaki, Yamaguchi Hiroki, Kato Koji, Atsuta Yoshiko, Takami Akiyoshi

    BLOOD   126 ( 3 )   415 - 422   2015.07( ISSN:0006-4971

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    DOI: 10.1182/blood-2015-04-642652

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  • 初回治療としてCHOP-R療法を選択した縦隔原発大細胞型B細胞性リンパ腫 Reviewed

    田垣内 優美, 西本 光孝, 林 良樹, 幕内 陽介, 久野 雅智, 高桑 輝人, 岡村 浩史, 吉村 卓朗, 康 史朗, 南野 智, 廣瀬 朝生, 中前 美佳, 中嶋 康博, 康 秀男, 中根 孝彦, 中前 博久, 大澤 政彦, 日野 雅之

    「血液診療」編集委員会 血液診療   11 ( 1 )   16 - 20   2015.07

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    症例は43歳、女性。前医にて前縦隔腫瘤を指摘され、胸腺癌の疑いで切除術を施行された。術後病理検査の結果、悪性リンパ腫の診断であった。当院にて精査の結果、縦隔原発大細胞型B細胞性リンパ腫(primary mediastinal large B-cell lymphoma、PMBL)の臨床病期IV期と診断した。初回治療としてCHOP-R療法を選択し、現在3コースまで施行し、経過良好である。PMBLはまれな疾患であり、リスク分類および治療選択に関してはまだ十分に確立されていない。今回我々は若年女性に発症した初発PMBLの1例を経験した。初回治療選択および長期治療戦略に関して文献的考察を加えて報告する。(著者抄録)

  • DIAGNOSTIC VALUE OF PLASMA LEVELS OF PRESEPSIN (SOLUBLE CD14-SUBTYPE) FOR FEBRILE NEUTROPENIA IN PATIENTS WITH HEMATOLOGIC MALIGNANCIES Reviewed

    Koh H., Katayama T., Hashiba M., Sato A., Kuno M., Makuuchi Y., Takakuwa T., Okamura H., Hirose A., Nakamae M., Hino M., Nakamae H.

    HAEMATOLOGICA   100   715 - 715   2015.06( ISSN:0390-6078

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  • PLASMA LEVELS OF PRESEPSIN (SOLUBLE CD14-SUBTYPE) AS A NOVEL PROGNOSTIC MARKER FOR HEMOPHAGOCYTIC SYNDROME Reviewed

    Nanno S., Koh H., Katayama T., Hashiba M., Sato A., Makuuchi Y., Nagasaki J., Yoshimura T., Okamura H., Nishimoto M., Hirose A., Nakamae M., Nakane T., Hino M., Nakamae H.

    HAEMATOLOGICA   100   557 - 557   2015.06( ISSN:0390-6078

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  • Cold autoimmune hemolytic anemia complicated with relapsed myelodysplastic syndrome after allogeneic hematopoietic cell transplantation Reviewed

    OKAMURA Hiroshi, NAKANE Takahiko, FUJINO Keizo, KOH Shiro, YOSHIMURA Takuro, NISHIMOTO Mitsutaka, HAYASHI Yoshiki, KOH Hideo, NAKAO Yoshitaka, NAKAMAE Hirohisa, HINO Masayuki

    The Japanese Society of Hematology, Rinsho Ketsueki   56 ( 4 )   412 - 7   2015.04( ISSN:0485-1439

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    Myelodysplastic syndrome (MDS) is known to often be complicated by a range of autoimmune diseases. We herein present a case with MDS complicated by cold autoimmune hemolytic anemia (cold AIHA). The patient was a 51-year-old woman. She was diagnosed with MDS (refractory cytopenia with multilineage dysplasia) in May 2009. In January 2010, she underwent unrelated allogeneic bone marrow transplantation but was re-admitted in October 2010 for treatment of relapsed MDS. Despite daily transfusions of red blood cells, her anemia failed to improve. Her laboratory examinations showed a low haptoglobin level and elevation of indirect bilirubin and LDH. The direct Coombs test was positive at a low and at room temperature and cold agglutinin was negative. After confirming the diagnosis of cold AIHA, all transfusion fluids were warmed but her anemia still failed to improve. In addition to the warmed transfusion fluids, we administered corticosteroids, immunosuppressive agents and high-dose intravenous immunoglobulin infusions. This management strategy ameliorated the patients hemolytic anemia. To our knowledge, MDS cases complicated by cold AIHA are rare. Our patient thus provides a valuable contribution to medical knowledge.

    DOI: 10.11406/rinketsu.56.412

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  • 骨髄異形成症候群の同種造血幹細胞移植後再発に合併した冷式自己免疫性溶血性貧血 Reviewed

    岡村 浩史, 中根 孝彦, 藤野 恵三, 康 史郎, 吉村 卓朗, 西本 光孝, 林 良樹, 康 秀男, 中尾 吉孝, 中前 博久, 日野 雅之

    (一社)日本血液学会-東京事務局 臨床血液   56 ( 4 )   412 - 417   2015.04( ISSN:0485-1439

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    骨髄異形成症候群(myelodysplastic syndrome,MDS)は様々な自己免疫疾患を合併する事が知られている。我々はMDSに冷式自己免疫性溶血性貧血(cold autoimmune hemolytic anemia,冷式AIHA)を合併した症例を経験した。症例は51歳女性。2009年5月MDS(refractory cytopenia with multilineage dysplasia,RCMD)と診断され2010年1月非血縁者間同種骨髄移植を施行したが,その後MDS再発を来たし同年10月当院入院となった。入院後貧血に対し連日の赤血球輸血を施行も貧血改善は得られず,ハプトグロビン低下,間接ビリルビン上昇,LDH上昇を認めた。直接クームス試験は低温,室温下で陽性であり寒冷凝集素は陰性であった。冷式AIHAの合併と診断し,全ての輸液,輸血を加温したが貧血の改善は認めず,加温に加え副腎皮質ホルモン,免疫抑制剤投与,γグロブリン大量静注療法を施行したところ溶血所見の改善が得られた。MDSと冷式AIHAの合併例の報告はわずかであり貴重な症例と考えられた。(著者抄録)

  • Drug interaction and safety profiles of concomitant use of caspofungin and tacrolimus in allogeneic hematopoietic stem cell transplant recipients Reviewed

    Nishimoto M., Koh H., Tokuwame A., Makuuchi Y., Kuno M., Takakuwa T., Okamura H., Koh S., Yoshimura T., Nanno S., Hayashi Y., Nakamae M., Hirose A., Nakashima Y., Nakane T., Hino M., Nakamae H.

    BONE MARROW TRANSPLANTATION   50   S408 - S408   2015.03( ISSN:0268-3369

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  • Response-guided therapy for steroid-refractory acute GVHD starting with very-low-dose antithymocyte globulin Reviewed

    Nishimoto Mitsutaka, Nakamae Hirohisa, Koh Hideo, Nakamae Mika, Hirose Asao, Hayashi Yoshiki, Nakashima Yasuhiro, Nakane Takahiko, Hino Masayuki

    EXPERIMENTAL HEMATOLOGY   43 ( 3 )   177 - 179   2015.03( ISSN:0301-472X

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    DOI: 10.1016/j.exphem.2014.11.008

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  • Impact of HLA Mismatch Direction on the Outcome of Unrelated Bone Marrow Transplantation: A Retrospective Analysis from the Japan Society for Hematopoietic Cell Transplantation Reviewed

    Kanda Junya, Ichinohe Tatsuo, Fuji Shigeo, Maeda Yoshinobu, Ohashi Kazuteru, Fukuda Takahiro, Miyamura Koichi, Iwato Koji, Eto Tetsuya, Nakamae Hirohisa, Kobayashi Naoki, Mori Takehiko, Mori Shin-ichiro, Morishima Yasuo, Atsuta Yoshiko, Kanda Yoshinobu

    BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION   21 ( 2 )   305 - 311   2015.02( ISSN:1083-8791

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    DOI: 10.1016/j.bbmt.2014.10.015

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  • Optic Neuritis Associated with Myelodysplastic Syndrome Accompanied by Eosinophilic Crisis Reviewed

    Nagasaki Joji, Nishimoto Mitsutaka, Nakamae Hirohisa, Nakane Takahiko, Koh Hideo, Yoshimoto Kumiko, Shiraki Kunihiko, Hino Masayuki

    The Japanese Society of Internal Medicine INTERNAL MEDICINE   54 ( 17 )   2241 - 2244   2015( ISSN:0918-2918

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    Myelodysplastic syndrome (MDS) was diagnosed in a 64-year-old man. Three months later, he presented with right-sided visual loss. A diagnosis of optic neuritis caused by both ischemic and non-ischemic changes was established. Concurrently, prominent eosinophilia was seen in both the peripheral blood and bone marrow. A partial improvement of visual loss was obtained concomitant with a rapid decrease of the eosinophils after treatment with corticosteroids. Optic neuritis related to MDS is a rare condition and its etiology has not yet been identified. We herein report a case of optic neuritis associated with MDS and accompanied by an eosinophilic crisis.<br>

    DOI: 10.2169/internalmedicine.54.4148

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  • Rectal biopsy, rather than ileal, is appropriate to confirm the diagnosis of early gastrointestinal graft-versus-host disease Reviewed

    Minamino Hiroaki, Machida Hirohisa, Tominaga Kazunari, Morimoto Kenichi, Ominami Masaki, Fukunaga Shusei, Hosomi Shuhei, Hayashi Yoshiki, Nagami Yasuaki, Sugimori Satoshi, Kamata Noriko, Shiba Masatsugu, Nakamae Hirohisa, Yamagami Hirokazu, Tanigawa Tetsuya, Watanabe Toshio, Fujiwara Yasuhiro, Ohsawa Masahiko, Hino Masayuki, Arakawa Tetsuo

    SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY   50 ( 11 )   1428 - 1434   2015( ISSN:0036-5521

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    DOI: 10.3109/00365521.2015.1054421

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  • Prognostic Value and Clinical Implication of Serum Ferritin Levels following Allogeneic Hematopoietic Cell Transplantation Reviewed

    Nakamae Mika, Nakamae Hirohisa, Koh Shiro, Koh Hideo, Nishimoto Mitsutaka, Nakashima Yasuhiro, Nakane Takahiko, Hirose Asao, Hino Masayuki

    ACTA HAEMATOLOGICA   133 ( 3 )   310 - 316   2015( ISSN:0001-5792

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    DOI: 10.1159/000365779

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  • Bone marrow-derived stromal cells are associated with gastric cancer progression Reviewed

    Kasashima Hiroaki, Yashiro Masakazu, Nakamae Hirohisa, Yuichiro Miki, Kitayama Kisyu, Masuda Go, Sakurai Katsunobu, Toyokawa Takahiro, Kubo Naoshi, Tanaka Hiroaki, Muguruma Kazuya, Ohira Masaichi, Nakane Takahiko, Hino Masayuki, Hirakawa Kosei

    Japanese Society for Molecular Tumor Marker Research, Japan Journal of Molecular Tumor Marker Research   31 ( 0 )   71 - 72   2015

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    DOI: 10.11241/jsmtmr.31.71

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  • Diagnostic performance of serum high-sensitivity procalcitonin and serum C-reactive protein tests for detecting bacterial infection in febrile neutropenia Reviewed

    Aimoto Mizuki, Koh Hideo, Katayama Takako, Okamura Hiroshi, Yoshimura Takuro, Koh Shiro, Nanno Satoru, Nishimoto Mitsutaka, Hirose Asao, Nakamae Mika, Nakane Takahiko, Nakamae Hirohisa, Kakeya Hiroshi, Hino Masayuki

    INFECTION   42 ( 6 )   971 - 979   2014.12( ISSN:0300-8126

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    DOI: 10.1007/s15010-014-0657-6

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  • Treatment of Patients with Adult T Cell Leukemia/Lymphoma with Cord Blood Transplantation: A Japanese Nationwide Retrospective Survey Reviewed

    Kato Koji, Choi Ilseung, Wake Atsushi, Uike Naokuni, Taniguchi Shuichi, Moriuchi Yukiyoshi, Miyazaki Yasushi, Nakamae Hirohisa, Oku Eijirou, Murata Makoto, Eto Tetsuya, Akashi Koichi, Sakamaki Hisashi, Kato Koji, Suzuki Ritsuro, Yamanaka Takeharu, Utsunomiya Atae

    BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION   20 ( 12 )   1968 - 1974   2014.12( ISSN:1083-8791

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    DOI: 10.1016/j.bbmt.2014.08.012

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  • Allogeneic Hematopoietic Stem Cell Transplantation for Patients with Acute Myeloid Leukemia Transformed from Ph-Negative Myeloproliferative Neoplasm: A Study from the Adult AML Working Group of the Japan Society for Hematopoietic Cell Transplantation (JSHCT) Reviewed

    Shinsuke Takagi, Kazuhiro Masuoka, Naoyuki Uchida, Mineo Kurokawa, Hirohisa Nakamae, Mitsuru Tsudo, Koji Iwato, Tatsuo Ichinohe, Yoshiko Atsuta, Akiyoshi Takami

    BLOOD   124 ( 21 )   2014.12( ISSN:0006-4971

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    56th Annual Meeting of the American-Society-of-Hematology, San Francisco, CA, DEC 06-09, 2014

  • Donor Lymphocyte Infusion for the Treatment of Relapsed Acute Myeloid Leukemia after Allogeneic Hematopoietic Stem Cell Transplantation: A Retrospective Analysis by the Adult Acute Myeloid Leukemia Working Group of the Japan Society for Hematopoietic Cell Transplantation Reviewed

    Takami Akiyoshi, Yano Shingo, Yokoyama Hiroki, Kuwatsuka Yachiyo, Yamaguchi Takuhiro, Kanda Yoshinobu, Morishima Yasuo, Fukuda Takahiro, Miyazaki Yasushi, Nakamae Hirohisa, Tanaka Junji, Atsuta Yoshiko, Kanamori Heiwa

    BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION   20 ( 11 )   1785 - 1790   2014.11( ISSN:1083-8791

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    DOI: 10.1016/j.bbmt.2014.07.010

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  • Efficacy and safety of dasatinib versus imatinib in the East Asian subpopulation of the DASISION trial of newly diagnosed chronic myeloid leukemia in chronic phase Reviewed

    Chuah Charles T., Nakamae Hirohisa, Shen Zhixiang X., Bradley-Garelik M. Brigid, Kim Dong-Wook

    LEUKEMIA & LYMPHOMA   55 ( 9 )   2093 - 2100   2014.09( ISSN:1042-8194

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    DOI: 10.3109/10428194.2013.866663

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  • Prospective long-term study of hepatitis B virus reactivation in patients with hematologic malignancy Reviewed

    Tamori Akihiro, Hino Masayuki, Kawamura Etsushi, Fujii Hideki, Uchida-Kobayashi Sawako, Morikawa Hiroyasu, Nakamae Hirohisa, Enomoto Masaru, Murakami Yoshiki, Kawada Norifumi

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   29 ( 9 )   1715 - 1721   2014.09( ISSN:0815-9319

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    DOI: 10.1111/jgh.12604

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  • Feasibility of umbilical cord blood transplantation with a myeloablative, reduced toxicity-conditioning regimen Reviewed

    Nishimoto M., Nakamae H., Nakamae M., Hirose A., Hagihara K., Koh H., Nakane T., Terada Y., Hino M.

    BONE MARROW TRANSPLANTATION   49 ( 7 )   980 - 981   2014.07( ISSN:0268-3369

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    DOI: 10.1038/bmt.2014.60

  • DISCONTINUATION OF DASATINIB IN PATIENTS WITH CML WHO HAVE MAINTAINED COMPLETE MOLECULAR RESPONSE FOR AT LEAST ONE YEAR: RESULTS FROM A PROSPECTIVE DISCONTINUATION (DADI) TRIAL Reviewed

    Kimura S., Imagawa J., Okada M., Nakamae H., Hino M., Murai K., Ishida Y., Kumagai T., Sato S., Ohashi K., Sakamaki H., Wakita H., Uoshima N., Nakagawa Y., Minami Y., Ogasawara M., Takeoka T., Akasaka H., Utsumi T., Uike N., Sato T., Ando S., Morita S., Sakamoto J., Tanaka H.

    HAEMATOLOGICA   99   78 - 79   2014.06( ISSN:0390-6078

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  • UNRELATED BONE MARROW TRANSPLANTATION WITH REDUCED INTENSITY CONDITIONING REGIMEN FOR ELDERLY PATIENTS WITH ADULT T-CELL LEUKEMIA/LYMPHOMA, FEASIBILITY STUDY WITH TWO-YEAR FOLLOW UP DATA Reviewed

    Choi I., Eto T., Tanosaki R., Shimokawa M., Takatsuka Y., Utsunomiya A., Takemoto S., Taguchi J., Fukushima T., Kato K., Teshima T., Nakamae H., Suehiro Y., Yamanaka T., Okamura J., Uike N.

    HAEMATOLOGICA   99   425 - 425   2014.06( ISSN:0390-6078

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  • Posterior reversible encephalopathy syndrome following acute pancreatitis during chemotherapy for acute monocytic leukemia. Reviewed

    Nishimoto M, Koh H, Bingo M, Yoshida M, Nanno S, Hayashi Y, Nakane T, Nakamae H, Shimono T, Hino M

    [Rinsho ketsueki] The Japanese journal of clinical hematology   55 ( 5 )   552 - 7   2014.05( ISSN:0485-1439

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  • Diffuse large B-cell lymphoma with hemolytic crisis developed twenty years after the onset of Evans syndrome. Reviewed

    Yoshimura T, Nakane T, Kamesaki T, Inaba A, Nishimoto M, Mukai S, Sakabe M, Ohsawa M, Fujino K, Koh H, Nakao Y, Nakamae H, Hino M

    [Rinsho ketsueki] The Japanese journal of clinical hematology   55 ( 5 )   546 - 51   2014.05( ISSN:0485-1439

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  • Evans症候群罹患後20年を経過して発症した溶血発作を伴うdiffuse large B-cell lymphoma Reviewed

    吉村 卓朗, 中根 孝彦, 亀崎 豊実, 稲葉 晃子, 西本 光孝, 向井 悟, 坂部 真奈美, 大澤 政彦, 藤野 惠三, 康 秀男, 中尾 吉孝, 中前 博久, 日野 雅之

    (一社)日本血液学会-東京事務局 臨床血液   55 ( 5 )   546 - 551   2014.05( ISSN:0485-1439

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    症例は65歳女性,1992年5月にクームス試験陽性自己免疫性溶血性貧血と赤芽球癆の合併と診断された。その後赤芽球癆は改善したが,新たに血小板減少を認め,骨髄検査にて特発性血小板減少性紫斑病の合併と考えられ,Evans症候群と診断された。Prednisoloneおよびazathioprineを投与し軽快,以後約20年に渡り投薬を漸減しつつ寛解増悪を繰り返していた。2012年10月,溶血発作の再増悪とB症状及びリンパ節腫脹が出現した。リンパ節生検の結果DLBCLと診断された。一方クームス試験は陰性,精査にてクームス陰性自己免疫性溶血性貧血も否定的であり,リンパ腫に関連した他の原因による溶血の可能性が疑われた。CHOP療法を施行したところ,溶血およびB症状は改善し,リンパ節病変も縮小を認めた。Evans症候群後DLBCLの発症の報告は稀であり,示唆に富む症例と考えられ,今回報告する。(著者抄録)

  • 化学療法中の急性膵炎に続発して可逆性後頭葉白質脳症を発症した急性単球性白血病 Reviewed

    西本 光孝, 康 秀男, 備後 真登, 吉田 全宏, 南野 智, 林 良樹, 中根 孝彦, 中前 博久, 下野 太郎, 日野 雅之

    (一社)日本血液学会-東京事務局 臨床血液   55 ( 5 )   552 - 557   2014.05( ISSN:0485-1439

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    症例は18歳男性。急性白血病に対して,大量シタラビンによる3回目の地固め療法を開始した。Day 15に発熱性好中球減少症を発症,翌日には敗血症性ショックによる急性呼吸窮迫症候群を合併し,抗菌薬に加えステロイドパルス療法を施行した。Day 22には薬剤性急性腎不全に対し人工透析を単回施行した。Day 24にステロイドが誘因と考えられる急性膵炎を発症,翌日に突然の痙攣発作を認め,人工呼吸管理となった。髄液検査は正常。頭部MRI検査で両側頭頂後頭葉にT2強調画像,FLAIR像で高信号病変を認め,みかけの拡散係数値の上昇から血管性浮腫を疑い,可逆性後頭葉白質脳症(PRES,posterior reversible encephalopathy syndrome)と診断した。痙攣,血圧ならびに体液量管理により改善を認め,day 49に軽快退院となった。高血圧やカルシニューリン阻害薬によるPRES以外に,報告は極めて稀であるが,急性膵炎後の発症も念頭に置いておく必要がある。(著者抄録)

  • CLINICAL CHARACTERISTICS OF HEPATITIS B VIRUS REACTIVATION IN A PROSPECTIVE LONG-TERM STUDY FOR PATIENTS WITH HEMATOLOGIC MALIGNANCY Reviewed

    Tamori A., Hino M., Kawamura E., Hagihara A., Fujii H., Uchida-Kobayashi S., Iwai S., Morikawa H., Nakamae H., Enomoto M., Murakami Y., Kawada N.

    JOURNAL OF HEPATOLOGY   60 ( 1 )   S285 - S286   2014.04( ISSN:0168-8278

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  • Cerebral toxoplasmosis after umbilical cord blood transplantation diagnosed by the detection of anti-toxoplasma specific IgM antibody in cerebrospinal fluid. Reviewed

    Inaba A, Koh H, Nakashima Y, Nishimoto M, Hayashi Y, Okamura H, Inoue A, Nanno S, Nakane T, Shimono T, Nakamae H, Hino M

    [Rinsho ketsueki] The Japanese journal of clinical hematology   55 ( 4 )   456 - 60   2014.04( ISSN:0485-1439

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  • 髄液中特異的IgM抗体が診断に有用であった臍帯血移植後トキソプラズマ脳症 Reviewed

    稲葉 晃子, 康 秀男, 中嶋 康博, 西本 光孝, 林 良樹, 岡村 浩史, 井上 敦司, 南野 智, 中根 孝彦, 下野 太郎, 中前 博久, 日野 雅之

    (一社)日本血液学会-東京事務局 臨床血液   55 ( 4 )   456 - 460   2014.04( ISSN:0485-1439

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    症例は60歳女性。骨髄異形成症候群に対して,臍帯血移植を施行した。再発消化管急性GVHD(Grade 2)に対してtacrolimus/mPSLによる治療を行っていたところ,day 210に発熱と意識障害を発症し,頭部造影MRI検査で,左視床や基底核,脳幹,皮質下白質にリング状造影効果を認める多発結節影を認めた。髄液と血中の抗トキソプラズマIgM,IgG抗体価はともに上昇しており,特にIgM抗体価は髄液の方が高く,トキソプラズマ脳症と診断した。sulfamethoxazole/trimethoprim合剤内服,clindamycin点滴と抗浮腫治療を開始したところ,症状,画像所見とも改善傾向となり,day 229の血清抗体価は不変であったが,髄液中抗体価は明らかに低下し,軽快退院となった。移植後トキソプラズマ脳症は発症時の確定診断が難しいため,治療の遅れが懸念される致死的合併症であるが,髄液中の特異的IgM抗体測定は早期診断に有用であり,また髄液中抗体価の推移は治療効果を反映する可能性が示唆された。(著者抄録)

  • PROMISING OUTCOMES FROM INTRA-ARTERIAL STEROID INFUSIONS IN PATIENTS WITH TREATMENT-RESISTANT ACUTE GASTROINTESTINAL GRAFT-VERSUS-HOST DISEASE Reviewed

    Nishimoto M., Koh H., Nakamae H., Hirose A., Nakamae M., Nakane T., Hayashi Y., Okamura H., Yoshimura T., Koh S., Nanno S., Nakashima Y., Takeshita T., Yamamoto A., Sakai Y., Nishida N., Matsuoka T., Miki Y., Hino M.

    BONE MARROW TRANSPLANTATION   49   S278 - S279   2014.03( ISSN:0268-3369

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  • DIAGNOSTIC VALUE OF SERUM FERRITIN AND RISK FACTORS FOR HEMOPHAGOCYTIC SYNDROME FOLLOWING ALLOGENEIC HEMATOPOIETIC CELL TRANSPLANTATION Reviewed

    Nanno S., Koh H., Nakashima Y., Katayama T., Kuno M., Makuuchi Y., Nagasaki J., Takakuwa T., Okamura H., Koh S., Yoshimura T., Nishimoto M., Nakamae M., Hirose A., Nakane T., Nakao Y., Nakamae H., Hino M.

    BONE MARROW TRANSPLANTATION   49   S472 - S473   2014.03( ISSN:0268-3369

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  • Efficacy and safety of dasatinib versus imatinib in Japanese patients with newly diagnosed chronic-phase chronic myeloid leukemia (CML-CP): Subset analysis of the DASISION trial with 2-year follow-up Reviewed

    Fujisawa Shin, Nakamae Hirohisa, Ogura Michinori, Ishizawa Ken-ichi, Taniwaki Masafumi, Utsunomiya Atae, Matsue Kosei, Takamatsu Yasushi, Usuki Kensuke, Tanimoto Mitsune, Ishida Yoji, Akiyama Hideki, Onishi Shintaro

    INTERNATIONAL JOURNAL OF HEMATOLOGY   99 ( 2 )   141 - 153   2014.02( ISSN:0925-5710

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    DOI: 10.1007/s12185-013-1470-1

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  • Voriconazole Vs. Itraconazole for Antifungal Prophylaxis in Patients with GVHD: A Randomized Trial Reviewed

    Hayashi Yoshiki, Kanda Yoshinobu, Nakamae Hirohisa, Kanamori Heiwa, Ohashi Kazuteru, Hidaka Michihiro, Yano Shingo, Hatanaka Kazuo, Kohno Akio, Moriuchi Yukiyoshi, Ago Hiroatsu, Yamashita Takuya, Takata Tohru, Yoshida Minoru, Hino Masayuki, Yamaguchi Takuhiro, Fukuda Takahiro

    BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION   20 ( 2 )   S91 - S91   2014.02( ISSN:1083-8791

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  • Diffuse large B-cell lymphoma with hemolytic crisis developed twenty years after the onset of Evans syndrome Reviewed

    YOSHIMURA Takuro, NAKANE Takahiko, KAMESAKI Toyomi, INABA Akiko, NISHIMOTO Mitsutaka, MUKAI Satoru, SAKABE Manami, OHSAWA Masahiko, FUJINO Keizo, KOH Hideo, NAKAO Yoshitaka, NAKAMAE Hirohisa, HINO Masayuki

    The Japanese Society of Hematology, Rinsho Ketsueki   55 ( 5 )   546 - 551   2014( ISSN:0485-1439

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    A 65-year-old woman was diagnosed with Coombs-positive autoimmune hemolytic anemia (AIHA) and pure red cell aplasia (PRCA) in May 1992. One month later, her PRCA went into remission following treatment but she developed idiopathic thrombocytopenic purpura and was diagnosed with Evans syndrome. Although her condition resolved with administration of prednisolone and azathioprine, it was necessary to continue treatment with gradual tapering over the following two decades. In October 2012, her hemolytic anemia again worsened, and lymph node swelling, splenomegaly and B symptoms developed. She was diagnosed as having diffuse large B-cell lymphoma (DLBCL) based on lymph node biopsy. However, AIHA was not considered to be the cause of her hemolytic anemia, but rather to be related to DLBCL. This was because a Coombs test and other extensive investigations for Coombs negative-AIHA yielded negative results. The patient underwent CHOP therapy, and all of her symptoms improved. Herein, we report this rare case in which DLBCL developed after the onset of Evans syndrome.

    DOI: 10.11406/rinketsu.55.546

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  • Posterior reversible encephalopathy syndrome following acute pancreatitis during chemotherapy for acute monocytic leukemia Reviewed

    NISHIMOTO Mitsutaka, KOH Hideo, BINGO Masato, YOSHIDA Masahiro, NANNO Satoru, HAYASHI Yoshiki, NAKANE Takahiko, NAKAMAE Hirohisa, SHIMONO Taro, HINO Masayuki

    The Japanese Society of Hematology, Rinsho Ketsueki   55 ( 5 )   552 - 557   2014( ISSN:0485-1439

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    We describe an 18-year-old man with acute leukemia who presented with posterior reversible encephalopathy syndrome (PRES) shortly after developing acute pancreatitis. On day 15 after the third consolidation course with high-dose cytarabine, treatment with broad-spectrum antibiotics was initiated for febrile neutropenia. On day 16, he developed septic shock, and subsequently, acute respiratory distress syndrome (ARDS). After adding vancomycin, micafungin and high-dose methylprednisolone (mPSL) to his treatment regimen, these manifestations subsided. On day 22, he received hemodialysis for drug-induced acute renal failure. On day 24, he developed acute pancreatitis possibly due to mPSL; the following day he had generalized seizures, and was intubated. Cerebrospinal fluid findings were normal. Brain MRI revealed hyperintense signals on FLAIR images and increased apparent diffusion coefficient values in the sub-cortical and deep white matter areas of the bilateral temporal and occipital lobes, indicative of vasogenic edema. Thus, we diagnosed PRES. Blood pressure, seizures and volume status were controlled, with MRI findings showing improvement by day 42. He was extubated on day 32 and discharged on day 49 without complications. Although little is known about PRES following acute pancreatitis, clinicians should be aware that this condition may develop.

    DOI: 10.11406/rinketsu.55.552

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  • Cerebral toxoplasmosis after umbilical cord blood transplantation diagnosed by the detection of anti-toxoplasma specific IgM antibody in cerebrospinal fluid Reviewed

    INABA Akiko, KOH Hideo, NAKASHIMA Yasuhiro, NISHIMOTO Mitsutaka, HAYASHI Yoshiki, OKAMURA Hiroshi, INOUE Atsushi, NANNO Satoru, NAKANE Takahiko, SHIMONO Taro, NAKAMAE Hirohisa, HINO Masayuki

    The Japanese Society of Hematology, Rinsho Ketsueki   55 ( 4 )   456 - 460   2014( ISSN:0485-1439

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    Cerebral toxoplasmosis is a rare, potentially fatal, complication of hematopoietic cell transplantation. Early definitive diagnosis is very difficult and it may be associated with a poor prognosis. Herein, we describe a 60-year-old woman who developed cerebral toxoplasmosis after cord blood transplantation for myelodysplastic syndrome. During treatment with tacrolimus and methylprednisolone for relapsed grade 2 acute gut GVHD, fever and disturbance of consciousness occurred on day 210. Brain MRI showed multiple ring-enhancing nodular lesions in the thalamus, basal ganglia, brainstem, and subcortical white matter. Cerebrospinal fluid (CSF) assessment revealed elevations of both anti-to-xoplasma IgM and IgG, which were also elevated in serum, but no evidence of other infections or malignancies. Notably, the IgM level was higher in the CSF than in serum. Thus, cerebral toxoplasmosis was diagnosed. Soon after administration of oral sulfamethoxazole/trimethoprim and intravenous clindamycin in combination with short-term dexamethasone for the cerebral edema, her symptoms and signs began to improve. On day 229, both IgM and IgG titers in CSF had clearly decreased but remained essentially constant in serum. She was discharged without clinically significant neurological disorders. This case suggests that CSF specific anti-toxoplasma IgM titers might be useful for early diagnosis of cerebral toxoplasmosis after transplantation.

    DOI: 10.11406/rinketsu.55.456

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  • Reduced-intensity vs myeloablative conditioning allogeneic hematopoietic SCT for patients aged over 45 years with ALL in remission: a study from the Adult ALL Working Group of the Japan Society for Hematopoietic Cell Transplantation (JSHCT) Reviewed

    Tanaka J., Kanamori H., Nishiwaki S., Ohashi K., Taniguchi S., Eto T., Nakamae H., Minagawa K., Miyamura K., Sakamaki H., Morishima Y., Kato K., Suzuki R., Nishimoto N., Oba K., Masauzi N.

    BONE MARROW TRANSPLANTATION   48 ( 11 )   1389 - 1394   2013.11( ISSN:0268-3369

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    DOI: 10.1038/bmt.2013.68

  • Reduced-intensity allogeneic stem cell transplantation for patients aged 50 years or older with B-cell ALL in remission: a retrospective study by the Adult ALL Working Group of the Japan Society for Hematopoietic Cell Transplantation Reviewed

    Kanamori H., Mizuta S., Kako S., Kato H., Nishiwaki S., Imai K., Shigematsu A., Nakamae H., Tanaka M., Ikegame K., Yujiri T., Fukuda T., Minagawa K., Eto T., Nagamura-Inoue T., Morishima Y., Suzuki R., Sakamaki H., Tanaka J.

    BONE MARROW TRANSPLANTATION   48 ( 12 )   1513 - 1518   2013.11( ISSN:0268-3369

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    DOI: 10.1038/bmt.2013.140

  • Refractoriness to platelet transfusion in acute myeloid leukemia correlated with the optical density of anti-platelet factor 4/heparin antibodies Reviewed

    Aimoto Mizuki, Yamane Takahisa, Shiomoto Kazumasa, Sakamoto Chikahiko, Nakashima Yasuhiro, Koh Hideo, Nakane Takahiko, Takeoka Yasunobu, Hirose Asao, Nakamae Mika, Hagihara Kiyoyuki, Terada Yoshiki, Nakao Yoshitaka, Nakamae Hirohisa, Hino Masayuki, Miyata Shigeki

    INTERNATIONAL JOURNAL OF HEMATOLOGY   98 ( 4 )   472 - 477   2013.10( ISSN:0925-5710

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    DOI: 10.1007/s12185-013-1427-4

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  • 急性骨髄性白血病における血小板輸血不応状態は抗血小板第4因子/ヘパリン複合体抗体の吸光度と相関する(Refractoriness to platelet transfusion in acute myeloid leukemia correlated with the optical density of anti-platelet factor 4/heparin antibodies) Reviewed

    Aimoto Mizuki, Yamane Takahisa, Shiomoto Kazumasa, Sakamoto Chikahiko, Nakashima Yasuhiro, Koh Hideo, Nakane Takahiko, Takeoka Yasunobu, Hirose Asao, Nakamae Mika, Hagihara Kiyoyuki, Terada Yoshiki, Nakao Yoshitaka, Nakamae Hirohisa, Hino Masayuki, Miyata Shigeki

    (一社)日本血液学会 International Journal of Hematology   98 ( 4 )   472 - 477   2013.10( ISSN:0925-5710

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    66歳女性。10日前に発熱および上気道症状が出現し、他院にて肺炎および急性骨髄性白血病(AML)と診断され、当院に転院となった。血小板輸血を行うも血小板数低値が持続し、ヒト白血球抗原(HLA)適合血小板輸血、副腎皮質ステロイド投与、高用量免疫グロブリン静注を行っても血小板輸血不応状態は改善しなかった。へパリン起因性血小板減少症の可能性を考慮し、9日目にヘパリンフラッシュを中止、ELISA法にて抗血小板第4因子(PF4)/ヘパリン複合体抗体を測定したところ、吸光度(OD)は2.1と高値を示した。21日目(ヘパリンフラッシュ中止12日後)に血小板輸血不応状態は消散し、AMLに対する化学療法を開始した。2コース実施後に完全寛解が得られたが、地固め療法実施下で再発をきたし死亡した。その後の検討で、抗PF4/ヘパリン複合体抗体のOD値の漸減と、OD値が1.0未満へ至ったときに血小板輸血不応状態が消散していた。

  • A multicenter clinical study evaluating the confirmed complete molecular response rate in imatinib-treated patients with chronic phase chronic myeloid leukemia by using the international scale of real-time quantitative polymerase chain reaction Reviewed

    Shinohara Yoshinori, Takahashi Naoto, Nishiwaki Kaichi, Hino Masayuki, Kashimura Makoto, Wakita Hisashi, Hatano Yoshiaki, Hirasawa Akira, Nakagawa Yasuaki, Itoh Kuniaki, Masuoka Hidekazu, Aotsuka Nobuyuki, Matsuura Yasuhiro, Takahara Sinobu, Sano Koji, Kuroki Jun, Hata Tomoko, Nakamae Hirohisa, Mugitani Atsuko, Nakane Takahiko, Miyazaki Yasushi, Niioka Takenori, Miura Masatomo, Sawada Kenichi

    HAEMATOLOGICA   98 ( 9 )   1407 - 1413   2013.09( ISSN:0390-6078

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    DOI: 10.3324/haematol.2013.085167

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  • Successful Treatment of Both Acute Leukemia and Active Crohn's Disease After Allogeneic Hematopoietic Stem Cell Transplantation Using Reduced-Intensity Conditioning With Fludarabine and Busulfan: A Case Report Reviewed

    Nishimoto M., Nakamae H., Watanabe K., Koh H., Nakane T., Ohsawa M., Arakawa T., Hino M.

    TRANSPLANTATION PROCEEDINGS   45 ( 7 )   2854 - 2857   2013.09( ISSN:0041-1345

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    DOI: 10.1016/j.transproceed.2013.03.049

  • Angioimmunoblastic T cell lymphoma complicated with endocapillary proliferative glomerulonephritis Reviewed

    NANNO Satoru, MAKAMAE Hirohisa, KUWAMURA Yukinobu, ISHIMURA Eiji, SAKABE Manami, INABA Akiko, KOH Shiro, YOSHIMURA Takuro, NISHIMOTO Mitsutaka, HAYASHI Yoshiki, TERADA Yoshiki, NAKANE Takahiko, KOH Hideo, NAKAO Yoshitaka, OHSAWA Masahiko, HINO Masayuki

    The Japanese Society of Hematology, Rinsho Ketsueki   54 ( 7 )   658 - 663   2013.07( ISSN:04851439

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    A 30-year-old female developed fever and multiple lymphadenopathy in September 2011. Her symptoms improved with antibiotic treatment. However, she again presented with fever and multiple lymphadenopathy in December 2011. In addition, she suffered from nephrotic syndrome with severe edema. She was therefore hospitalized to undergo detailed examinations. Renal biopsy revealed endocapillary proliferative glomerulonephritis. Since her renal function deteriorated rapidly, she was given steroid pulse therapy with methylprednisolone, followed by maintenance therapy with prednisolone. After treatment, her renal function improved but multiple lymphadenopathy persisted. Biopsy of a left axillary lymph node was then performed and revealed angioimmunoblastic T-cell lymphoma (AITL). She received CHOP therapy but showed no response. Therefore, she was given ESHAP therapy. A partial response was achieved and the nephrotic syndrome also resolved completely. We report this extremely rare case of renal dysfunction due to endocapillary proliferative glomerulonephritis complicated by AITL.

    DOI: 10.11406/rinketsu.54.658

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  • [Angioimmunoblastic T cell lymphoma complicated with endocapillary proliferative glomerulonephritis]. Reviewed

    Nanno S, Nakamae H, Kuwamura Y, Ishimura E, Sakabe M, Inaba A, Koh S, Yoshimura T, Nishimoto M, Hayashi Y, Terada Y, Nakane T, Koh H, Nakao Y, Ohsawa M, Hino M

    [Rinsho ketsueki] The Japanese journal of clinical hematology   54 ( 7 )   658 - 63   2013.07( ISSN:0485-1439

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  • 管内増殖性糸球体腎炎を合併した血管免疫芽球性T細胞性リンパ腫 Reviewed

    南野 智, 中前 博久, 桑村 幸伸, 石村 栄治, 坂部 真奈美, 稲葉 晃子, 康 史朗, 吉村 卓朗, 西本 光孝, 林 良樹, 寺田 芳樹, 中根 孝彦, 康 秀男, 中尾 吉孝, 大澤 政彦, 日野 雅之

    (一社)日本血液学会-東京事務局 臨床血液   54 ( 7 )   658 - 663   2013.07( ISSN:0485-1439

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    症例は30歳,女性。2011年9月より発熱,多発リンパ節腫脹を認めた。抗菌薬の投与により症状が軽快したが,同年12月より再び発熱,多発リンパ節腫脹が出現し,著明な浮腫を認め,ネフローゼ症状が出現した。精査加療目的で入院となり,腎生検で管内増殖性糸球体腎炎と診断。入院後,腎機能の悪化を認めたため,ステロイドパルス療法を行った後,ステロイドの継続投与を行った。腎機能は改善するも,リンパ節腫脹が残存したため,リンパ節生検を行い,血管免疫芽球性T細胞リンパ腫と診断した。診断後,CHOP療法を行ったが治療抵抗性で,サルベージ治療としてESHAP療法を行ったところ腎病変を含め奏効が得られた。その後,ネフローゼの再燃を認めていない。血管免疫芽球性T細胞リンパ腫に発症する腎障害の原因として,管内増殖性糸球体腎炎で発症することは稀であり,貴重な症例と考え報告する。(著者抄録)

  • Prognostic factors and outcomes of unrelated bone marrow transplantation for Philadelphia chromosome positive acute lymphoblastic leukemia (Ph+ALL) pre-treated with tyrosine kinase inhibitors. Reviewed

    Yoshimura T, Nakane T, Hirose A, Koh H, Nakamae M, Aimoto M, Nishimoto M, Hayashi Y, Terada Y, Nakamae H, Hino M

    Osaka city medical journal   59 ( 1 )   9 - 21   2013.06( ISSN:0030-6096

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  • チロシンキナーゼ阻害薬で事前治療を受けていたフィラデルフィア染色体陽性急性リンパ芽球性白血病(Ph+ALL)に対する非血縁者からの骨髄移植の予後予測因子と治療成績(Prognostic Factors and Outcomes of Unrelated Bone Marrow Transplantation for Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia(Ph+ALL) Pre-treated with Tyrosine Kinase Inhibitors) Reviewed

    Yoshimura Takuro, Nakane Takahiko, Hirose Asao, Koh Hideo, Nakamae Mika, Aimoto Mizuki, Nishimoto Mitsutaka, Hayashi Yoshiki, Terada Yoshiki, Nakamae Hirohisa, Hino Masayuki

    大阪市医学会 Osaka City Medical Journal   59 ( 1 )   9 - 21   2013.06( ISSN:0030-6096

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  • 消化管急性移植片対宿主病に対するベクロメタゾンプロピオン酸エステル製剤の有効性 Reviewed

    中前 博久, 西本 光孝, 徳和目 篤史, 日野 雅之

    (公財)臨床薬理研究振興財団 臨床薬理の進歩   ( 34 )   93 - 98   2013.06( ISSN:0914-4366

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    消化管急性移植片対宿主病に対するベクロメタゾンプロピオン酸エステル製剤(BDP)の有効性について検討した。同種造血幹細胞移植後に消化管急性GVHDを発症した血液悪性疾患4例を対象とした。4例中、少なくとも2例に完全寛解、部分寛解を認めた。4例中3例は非血縁臍帯血移植症例であった。全身ステロイド投与により感染症が併発あるいは、悪化することを懸念してBDPを投与し、感染症が併発あるいは、悪化した症例は認めなかった。BDP投与の効果を十分認めなった2例のうち1例は、一度、消化管GVHD grade 4まで進展を認め、下部消化管内視鏡での生検でもGVHDが持続していることを確認した。また、1例は、BDPによって一旦、消化管GVHD症状の改善が得られたが、急速なBDPの中止によって消化管GVHD症状の悪化を認め、その後、BDPの漸減を行うことで、消化管GVHDのコントロールが可能になった。

  • Double-Unit Cord Blood Transplantation after Myeloablative Conditioning for Patients with Hematologic Malignancies: A Multicenter Phase II Study in Japan Reviewed

    Kai Shunro, Wake Atsushi, Okada Masaya, Kurata Mio, Atsuta Yoshiko, Ishikawa Jun, Nakamae Hirohisa, Aotsuka Nobuyuki, Kasai Masaharu, Misawa Mahito, Taniguchi Shuichi, Kato Shunichi

    BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION   19 ( 5 )   812 - 819   2013.05( ISSN:1083-8791

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    DOI: 10.1016/j.bbmt.2013.02.011

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  • Acute myeloid leukemia with monosomy 7 and inv(3) (q21q26.2) complicated with central diabetes insipidus Reviewed

    NANNO Satoru, HAGIHARA Kiyoyuki, SAKABE Manami, OKAMURA Hiroshi, INABA Akiko, NAGATA Yuki, NISHIMOTO Mitsutaka, KOH Hideo, NAKAO Yoshitaka, NAKANE Takahiko, NAKAMAE Hirohisa, SHIMONO Taro, HINO Masayuki

    The Japanese Society of Hematology, Rinsho Ketsueki   54 ( 4 )   397 - 402   2013.04( ISSN:04851439

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    A 20-year-old female presented with thirst, polyposia, and polyuria and was referred to our hospital because of leukocytosis and anemia. Bone marrow aspiration revealed 66.8% myeloperoxidase-positive blasts and trilineage myelodysplasia. The karyotype was 45, XX, inv(3)(q21q26.2), -7[19]. Therefore, a diagnosis of AML with inv(3)(q21q26.2) complicated by -7 was made. Moreover, hyposthenuria and a low anti-diuretic hormone (ADH) level were observed. Although cerebrospinal fluid analysis was normal, magnetic resonance imaging (MRI) revealed the absence of hyperintensity in the neurohypophysis in T1-weighted images. Therefore, she was also diagnosed with diabetes insipidus. After she was administered a desmopressin nasal spray, the volume of urine produced decreased. Following treatment with second induction therapy containing high-dose cytarabine for AML, she achieved complete remission in the bone marrow. Moreover, when the abnormality on MRI and the volume of urine were normalized, she discontinued desmopressin. Although diabetes insipidus is a rare complication of AML, the majority of AML patients who have diabetes insipidus have the abnormal karyotypes with inv(3)(q21q26.2)/t(3;3)(q21;q26.2) and monosomy 7. Further study is required to clarify the pathogenesis and develop a strategy for the treatment of this category of AML.

    DOI: 10.11406/rinketsu.54.397

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  • Potential Contribution of a Novel Tax Epitope-Specific CD4(+) T Cells to Graft-versus-Tax Effect in Adult T Cell Leukemia Patients after Allogeneic Hematopoietic Stem Cell Transplantation Reviewed

    Tamai Yotaro, Hasegawa Atsuhiko, Takamori Ayako, Sasada Amane, Tanosaki Ryuji, Choi Ilseung, Utsunomiya Atae, Maeda Yasuhiro, Yamano Yoshihisa, Eto Tetsuya, Koh Ki-Ryang, Nakamae Hirohisa, Suehiro Youko, Kato Koji, Takemoto Shigeki, Okamura Jun, Uike Naokuni, Kannagi Mari

    JOURNAL OF IMMUNOLOGY   190 ( 8 )   4382 - 4392   2013.04( ISSN:0022-1767

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    DOI: 10.4049/jimmunol.1202971

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  • [Acute myeloid leukemia with monosomy 7 and inv(3)(q21q26.2) complicated with central diabetes insipidus]. Reviewed

    Nanno S, Hagihara K, Sakabe M, Okamura H, Inaba A, Nagata Y, Nishimoto M, Koh H, Nakao Y, Nakane T, Nakamae H, Shimono T, Hino M

    [Rinsho ketsueki] The Japanese journal of clinical hematology   54 ( 4 )   397 - 402   2013.04( ISSN:0485-1439

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  • [Acute transverse myelitis after allogeneic bone marrow transplantation for acute lymphoblastic leukemia--a case report]. Reviewed

    Manabe M, Nishimoto M, Ito K, Okamura H, Bingo M, Yoshida M, Inoue A, Aimoto M, Hayashi Y, Koh H, Nakane T, Nakamae M, Terada Y, Nakamae H, Nakao T, Koh KR, Hirai M, Nakao Y, Yamane T, Hino M

    Gan to kagaku ryoho. Cancer & chemotherapy   40 ( 4 )   529 - 32   2013.04( ISSN:0385-0684

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  • 中枢性尿崩症を合併した染色体-7とinv(3)(q21q26.2)を有する急性骨髄性白血病 Reviewed

    南野 智, 萩原 潔通, 坂部 真奈美, 岡村 浩史, 稲葉 晃子, 永田 友貴, 西本 光孝, 康 秀男, 中尾 吉孝, 中根 孝彦, 中前 博久, 下野 太郎, 日野 雅之

    (一社)日本血液学会-東京事務局 臨床血液   54 ( 4 )   397 - 402   2013.04( ISSN:0485-1439

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    症例は20歳女性。口渇,多飲,多尿が出現し,近医で白血球増多と貧血を認めたため当科に転院となった。骨髄検査ではミエロペルオキシダーゼ陽性芽球66.8%と3系統の異形成を認め,染色体検査ではinv(3)(q21q26.2),-7を認めたため,染色体-7を有したinv(3)(q21q26.2)を伴うAMLと診断した。一方,低張性多尿とADH低値を認め,髄液検査には異常所見を認めなかったが,頭部MRIではT1で下垂体後葉の高信号が消失していた。これらより中枢性尿崩症と診断し,デスモプレッシン点鼻を開始したところ尿量は減少した。AMLに対して2度の大量AraC療法を施行した結果,骨髄は寛解となった。さらに頭部MRIでは下垂体後葉の高信号が回復し,尿量は正常化した。その後デスモプレッシンを中止するも尿崩症の再燃は認めていない。中枢性尿崩症を合併したAMLは稀であるが,その中ではinv(3)(q21q26.2)/t(3;3)(q21;q26.2)と-7を有する症例が多く,今後,この疾患の病態・治療法の解明が望まれる。(著者抄録)

  • Risk factors affecting cardiac left-ventricular hypertrophy and systolic and diastolic function in the chronic phase of allogeneic hematopoietic cell transplantation Reviewed

    Nishimoto M., Nakamae H., Koh H., Nakane T., Nakamae M., Hirose A., Hagihara K., Nakao Y., Terada Y., Ohsawa M., Hino M.

    BONE MARROW TRANSPLANTATION   48 ( 4 )   581 - 586   2013.04( ISSN:0268-3369

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    DOI: 10.1038/bmt.2012.179

  • 同種骨髄移植後に急性横断性脊髄炎を合併した急性リンパ性白血病 Reviewed

    間部 賢寛, 西本 光孝, 伊藤 和博, 岡村 浩史, 備後 真登, 吉田 全宏, 井上 敦司, 相本 瑞樹, 林 良樹, 康 秀男, 中根 孝彦, 中前 美佳, 寺田 芳樹, 中前 博久, 中尾 隆文, 高 起良, 平井 学, 中尾 吉孝, 山根 孝久, 日野 雅之

    (株)癌と化学療法社 癌と化学療法   40 ( 4 )   529 - 532   2013.04( ISSN:0385-0684

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    症例は40歳、女性。分子学的寛解を得たPhiladelphia染色体陽性急性リンパ性白血病に対して、非血縁者間骨髄移植を実施した。day 90ごろより知覚異常、膀胱直腸障害および下肢筋力低下を認め、MRI所見も含めて急性横断性脊髄炎と診断した。ステロイドパルスおよび免疫グロブリン製剤投与を行い、症状の改善を得た。横断性脊髄炎は運動、知覚および自律神経系に異常を来す炎症性疾患であるが、造血幹細胞移植での合併例は比較的まれである。早期の診断および治療開始が機能的予後に影響するため、移植後の脊髄症には急性横断性脊髄炎を鑑別診断として念頭に置く必要性がある。(著者抄録)

  • Dasatinib Maintenance Therapy after Allogeneic Hematopoietic Stem Cell Transplantation for an Isolated Central Nervous System Blast Crisis in Chronic Myelogenous Leukemia Reviewed

    Nishimoto Mitsutaka, Nakamae Hirohisa, Koh Ki-Ryang, Kosaka Saori, Matsumoto Kana, Morita Kunihiko, Koh Hideo, Nakane Takahiko, Ohsawa Masahiko, Hino Masayuki

    ACTA HAEMATOLOGICA   130 ( 2 )   111 - 114   2013( ISSN:0001-5792

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    DOI: 10.1159/000347158

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  • Use of per Rectal Portal Scintigraphy to Detect Portal Hypertension in Sinusoidal Obstructive Syndrome following Unrelated Cord Blood Transplantation Reviewed

    Okamura Hiroshi, Hayashi Yoshiki, Nakamae Hirohisa, Shiomi Susumu, Nishimoto Mitsutaka, Koh Hideo, Nakane Takahiko, Hino Masayuki

    ACTA HAEMATOLOGICA   130 ( 2 )   83 - 86   2013( ISSN:0001-5792

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    DOI: 10.1159/000346438

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  • Fatal BK virus pneumonia following stem cell transplantation Reviewed

    Akazawa Y., Terada Y., Yamane T., Tanaka S., Aimoto M., Koh H., Nakane T., Koh K. -R., Nakamae H., Ohsawa M., Wakasa K., Hino M.

    TRANSPLANT INFECTIOUS DISEASE   14 ( 6 )   E142 - E146   2012.12( ISSN:1398-2273

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    DOI: 10.1111/tid.12011

  • IMMUNOGLOBULIN PROPHYLAXIS AGAINST CYTOMEGALOVIRUS INFECTION IN PATIENTS AT HIGH RISK OFINFECTION FOLLOWING ALLOGENEIC HEMATOPOIETIC CELL TRANSPLANTATION Reviewed

    Ichihara H., Nakamae H., Hirose A., Nakane T., Koh H., Hayashi Y., Nisimoto M., Nakamae M., Terada Y., Koh S., Yoshimura T., Aimoto M., Manabe M., Hagiwara K., Hino M.

    ANNALS OF ONCOLOGY   23   167 - 167   2012.10( ISSN:0923-7534

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  • MULTICENTER CLINICAL STUDY EVALUATING THE CONFIRMED CMR TO MMR RATIO AMONG IMATINIB-TREATED CHRONIC PHASE CHRONIC MYELOID LEUKEMIA PATIENTS USING INTERNATIONAL STANDARD RQ-PCR Reviewed

    Shinohara Y., Takahashi N., Nishiwaki K., Miura M., Nakamae H., Hino M., Miyazaki Y., Wakita H., Sawada K.

    HAEMATOLOGICA   97   309 - 309   2012.07( ISSN:0390-6078

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  • Different immunoprofiles in patients with chronic myeloid leukemia treated with imatinib, nilotinib or dasatinib Reviewed

    Hayashi Yoshiki, Nakamae Hirohisa, Katayama Takako, Nakane Takahiko, Koh Hideo, Nakamae Mika, Hirose Asao, Hagihara Kiyoyuki, Terada Yoshiki, Nakao Yoshitaka, Hino Masayuki

    LEUKEMIA & LYMPHOMA   53 ( 6 )   1084 - 1089   2012.06( ISSN:1042-8194

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    DOI: 10.3109/10428194.2011.647017

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  • Prognosis of acute myeloid leukemia harboring monosomal karyotype in patients treated with or without allogeneic hematopoietic cell transplantation after achieving complete remission Reviewed

    Yanada Masamitsu, Kurosawa Saiko, Yamaguchi Takuhiro, Yamashita Takuya, Moriuchi Yukiyoshi, Ago Hiroatsu, Takeuchi Jin, Nakamae Hirohisa, Taguchi Jun, Sakura Toru, Takamatsu Yasushi, Waki Fusako, Yokoyama Hiroki, Watanabe Masato, Emi Nobuhiko, Fukuda Takahiro

    HAEMATOLOGICA-THE HEMATOLOGY JOURNAL   97 ( 6 )   915 - 918   2012.06( ISSN:0390-6078

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    DOI: 10.3324/haematol.2011.058289

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  • Nilotinib versus imatinib in patients (pts) with newly diagnosed chronic myeloid leukemia in chronic phase (CML-CP): ENESTnd 3-year (yr) follow-up (f/u) Reviewed

    Kantarjian Hagop, Flinn Ian W., Goldberg Stuart, Bunworasate Udomsak, Zanichelli Maria Aparecida, Nakamae Hirohisa, Hughes Timothy P., Hochhaus Andreas, Saglio Giuseppe, Woodman Richard Charles, Blakesley Rick E., Kemp Charisse N., Kalaycio Matt E., Larson Richard A.

    JOURNAL OF CLINICAL ONCOLOGY   30 ( 15 )   2012.05( ISSN:0732-183X

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  • Population pharmacokinetic and exposure-response analysis of nilotinib in patients with newly diagnosed Ph plus chronic myeloid leukemia in chronic phase Reviewed

    Larson Richard A., Yin Ophelia Q. P., Hochhaus Andreas, Saglio Giuseppe, Clark Richard E., Nakamae Hirohisa, Gallagher Neil J., Demirhan Eren, Hughes Timothy P., Kantarjian Hagop M., le Coutre Philipp D.

    EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY   68 ( 5 )   723 - 733   2012.05( ISSN:0031-6970

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    DOI: 10.1007/s00228-011-1200-7

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  • 同種骨髄移植後のヒトヘルペスウイルス6(HHV6)脳脊髄炎による遷延性洞性頻脈(Prolonged Sinus Tachycardia Caused by Human Herpesvirus 6 (HHV6) Encephalomyelitis after Allogeneic Bone Marrow Transplantation) Reviewed

    Nishimoto Mitsutaka, Nakamae Hirohisa, Hayashi Yoshiki, Koh Hideo, Nakane Takahiko, Yoshida Masahiro, Bingo Masato, Okamura Hiroshi, Aimoto Mizuki, Nanno Satoru, Yoshimura Takuro, Inaba Akiko, Hagihara Kiyoyuki, Nakamae Mika, Hirose Asao, Nakao Yoshitaka, Terada Yoshiki, Hino Masayuki

    (一社)日本内科学会 Internal Medicine   51 ( 10 )   1265 - 1267   2012.05( ISSN:0918-2918

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    症例はフィラデルフィア染色体陽性の急性リンパ性白血病の19歳男性で、非血縁骨髄ドナーからの同種造血幹細胞移植を受けた。移植後20日めに意識障害および見当識障害が出現した。脳脊髄液検査にてHHV6Bが検出され、下肢の電撃痛・そう痒や排尿困難・排便困難などの症状がみられたことからHHV6脳脊髄炎と診断された。同時に洞性頻脈がみられた。ホスカルネット治療により血漿および脳脊髄液からHHV6ゲノムが消失しても、洞性頻脈は更に100日間続いた。HHV6脳脊髄炎による自律神経障害により遷延性の洞性頻脈が発生したと考えられた。

  • 好酸球増加症は重症度に関係なく同種造血幹細胞移植後の良好な転帰に関連する(Eosinophilia, Regardless of Degree, is Related to Better Outcomes after Allogeneic Hematopoietic Stem Cell Transplantation) Reviewed

    Nakane Takahiko, Nakamae Hirohisa, Hirose Asao, Nakamae Mika, Koh Hideo, Hayashi Yoshiki, Nishimoto Mitsutaka, Umemoto Yukari, Yoshimura Takuro, Bingo Masato, Okamura Hiroshi, Yoshida Masahiro, Ichihara Hiroyoshi, Aimoto Mizuki, Terada Yoshiki, Nakao Yoshitaka, Ohsawa Masahiko, Hino Masayuki

    (一社)日本内科学会 Internal Medicine   51 ( 8 )   851 - 858   2012.04( ISSN:0918-2918

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    好酸球増加症の重症度が同種造血幹細胞移植(allo-HCT)後の転帰に及ぼす影響について検討した。allo-HCTを実施した血液悪性腫瘍の患者144例を対象とした。幹細胞源は84例が骨髄、32例が末梢血幹細胞、28例が臍帯血であった。112例が骨髄破壊的前処置を受け、49例はハイリスク疾患であった。Semi-landmark解析を行って好酸球増加症の影響を検討した。移植後47日(中央値)で63例(44%)に好酸球増加症が発現した。好酸球増加症を発現した患者の3年全生存率(OS)は、好酸球増加症のない患者よりも有意に高く、3年再発率は有意に低かった。好酸球増加症を軽度群と重度群に分類した後の解析では、3年OSがそれぞれ68%と65%、3年再発率が31%と28%であった。多変量解析の結果、好酸球増加症は再発率の低さと有意に関連しており、同様の傾向は軽度群と重度群別の解析でも認められた。allo-HCT後の好酸球増加症は、重症度に関係なく、高いOSと低い再発率に関連することが示唆された。

  • Reagents for astatination of biomolecules. 6. An intact antibody conjugated with a maleimido-closo-decaborate(2-) reagent via sulfhydryl groups had considerably higher kidney concentrations than the same antibody conjugated with an isothiocyanato-closo-decaborate(2-) reagent via lysine amines. Reviewed

    Wilbur DS, Chyan MK, Nakamae H, Chen Y, Hamlin DK, Santos EB, Kornblit BT, Sandmaier BM

    Bioconjugate chemistry   23 ( 3 )   409 - 20   2012.03( ISSN:1043-1802

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    DOI: 10.1021/bc200401b

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  • Prolonged sinus tachycardia caused by human herpesvirus 6 (HHV6) encephalomyelitis after allogeneic bone marrow transplantation. Reviewed

    Nishimoto M, Nakamae H, Hayashi Y, Koh H, Nakane T, Yoshida M, Bingo M, Okamura H, Aimoto M, Nanno S, Yoshimura T, Inaba A, Hagihara K, Nakamae M, Hirose A, Nakao Y, Terada Y, Hino M

    Internal medicine (Tokyo, Japan)   51 ( 10 )   1265 - 7   2012( ISSN:0918-2918

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  • Prolonged Sinus Tachycardia Caused by Human Herpesvirus 6 (HHV6) Encephalomyelitis after Allogeneic Bone Marrow Transplantation Reviewed

    Nishimoto Mitsutaka, Nakamae Hirohisa, Hayashi Yoshiki, Koh Hideo, Nakane Takahiko, Yoshida Masahiro, Bingo Masato, Okamura Hiroshi, Aimoto Mizuki, Nanno Satoru, Yoshimura Takuro, Inaba Akiko, Hagihara Kiyoyuki, Nakamae Mika, Hirose Asao, Nakao Yoshitaka, Terada Yoshiki, Hino Masayuki

    The Japanese Society of Internal Medicine INTERNAL MEDICINE   51 ( 10 )   1265 - 1267   2012( ISSN:0918-2918

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    A 19-year-old man with Philadelphia chromosome-positive acute lymphoblastic leukemia received an allogeneic hematopoietic cell transplant with unrelated bone marrow. On day 20, the patient developed impaired consciousness and disorientation. Examination of the cerebrospinal fluid showed 2×10<sup>4</sup> copies/mL of HHV6B. HHV6 encephalitis was diagnosed, as had HHV6 myelitis based on symptoms that included lancinating pain/pruritus in the lower limbs and dysuria/dyschezia. Concurrently, he showed sinus tachycardia. Even after clearance of the HHV6 genome from the plasma and CSF was achieved by treatment with foscarnet, sinus tachycardia persisted for another 100 days. We suspected prolonged sinus tachycardia due to dysautonomia caused by HHV6 encephalomyelitis.<br>

    DOI: 10.2169/internalmedicine.51.6640

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  • Eosinophilia, regardless of degree, is related to better outcomes after allogeneic hematopoietic stem cell transplantation. Reviewed

    Nakane T, Nakamae H, Hirose A, Nakamae M, Koh H, Hayashi Y, Nishimoto M, Umemoto Y, Yoshimura T, Bingo M, Okamura H, Yoshida M, Ichihara H, Aimoto M, Terada Y, Nakao Y, Ohsawa M, Hino M

    Internal medicine (Tokyo, Japan)   51 ( 8 )   851 - 8   2012( ISSN:0918-2918

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  • Eosinophilia, Regardless of Degree, is Related to Better Outcomes after Allogeneic Hematopoietic Stem Cell Transplantation Reviewed

    Nakane Takahiko, Nakamae Hirohisa, Hirose Asao, Nakamae Mika, Koh Hideo, Hayashi Yoshiki, Nishimoto Mitsutaka, Umemoto Yukari, Yoshimura Takuro, Bingo Masato, Okamura Hiroshi, Yoshida Masahiro, Ichihara Hiroyoshi, Aimoto Mizuki, Terada Yoshiki, Nakao Yoshitaka, Ohsawa Masahiko, Hino Masayuki

    The Japanese Society of Internal Medicine INTERNAL MEDICINE   51 ( 8 )   851 - 858   2012( ISSN:0918-2918

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    <b>Objective</b> Several recent studies report that, after allogeneic hematopoietic cell transplantation (allo-HCT), eosinophilia is a favorable factor for transplant outcomes. However, whether the degree of eosinophilia influences transplant outcomes is yet to be established.<br> <b>Methods</b> We studied 144 patients with hematological malignancy who received allo-HCT at our institution. The stem cell sources were bone marrow in 84 patients, peripheral blood stem cells in 32 patients, and cord blood in 28 patients. One hundred and twelve patients underwent myeloablative conditioning and 49 patients had high-risk disease. We performed semi-landmark analysis to examine the influence of eosinophilia.<br> <b>Results</b> Eosinophilia developed at a median of 47 days after transplantation in 63 patients (44%). The patients with eosinophilia showed significantly better overall survival (OS) and a lower relapse rate at three years, compared to those without eosinophilia (66% vs 55%, p=0.04 and 30% vs 50%, p=0.002). On analysis following division into groups with mild (500-1,500×10<sup>6</sup>/L) and hyper- (>1,500×10<sup>6</sup>/L) eosinophilia, three-year OS and relapse rates were 68% and 65% (p=0.92), and 31% and 28% (p=0.90), respectively. On multivariate analysis, eosinophilia was significantly associated with lower relapse rates [HR: 0.5 (95% CI: 0.3-0.9), p=0.01] and the same trend was preserved in the analysis of the mild and hyper-eosinophilic groups.<br> <b>Conclusion</b> The results suggest that eosinophilia after allo-HCT was associated with better OS and a lower relapse rate, regardless of the levels. The mechanism of this effect is still unclear, and requires study of the pathophysiological process to clarify the relationship between the higher levels of eosinophilia after allo-HCT and organ infiltration.<br>

    DOI: 10.2169/internalmedicine.51.6726

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  • Serum Cytokine Profiles in Hemophagocytic Syndrome following Allogeneic Hematopoietic Stem Cell Transplantation Reviewed

    Koh Hideo, Nakane Takahiko, Sakamoto Erina, Katayama Takako, Nakamae Hirohisa, Ohsawa Masahiko, Hino Masayuki

    ACTA HAEMATOLOGICA   127 ( 3 )   182 - 185   2012( ISSN:0001-5792

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    DOI: 10.1159/000335536

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  • Cytopenias after day 28 in allogeneic hematopoietic cell transplantation: impact of recipient/donor factors, transplant conditions and myelotoxic drugs Reviewed

    Nakamae Hirohisa, Storer Barry, Sandmaier Brenda M., Maloney David G., Davis Chris, Corey Lawrence, Storb Rainer, Boeckh Michael

    HAEMATOLOGICA-THE HEMATOLOGY JOURNAL   96 ( 12 )   1838 - 1845   2011.12( ISSN:0390-6078

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    DOI: 10.3324/haematol.2011.044966

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  • Immunoglobulin Prophylaxis Against Cytomegalovirus Infection in Patients at High Risk of Infection Following Allogeneic Hematopoietic Cell Transplantation Reviewed

    Ichihara H., Nakamae H., Hirose A., Nakane T., Koh H., Hayashi Y., Nishimoto M., Nakamae M., Yoshida M., Bingo M., Okamura H., Aimoto M., Manabe M., Hagihara K., Terada Y., Nakao Y., Hino M.

    TRANSPLANTATION PROCEEDINGS   43 ( 10 )   3927 - 3932   2011.12( ISSN:0041-1345

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    DOI: 10.1016/j.transproceed.2011.08.104

  • Nilotinib versus imatinib for the treatment of patients with newly diagnosed chronic phase, Philadelphia chromosome-positive, chronic myeloid leukaemia: 24-month minimum follow-up of the phase 3 randomised ENESTnd trial Reviewed

    Kantarjian Hagop M., Hochhaus Andreas, Saglio Giuseppe, De Souza Carmino, Flinn Ian W., Stenke Leif, Goh Yeow-Tee, Rosti Gianantonio, Nakamae Hirohisa, Gallagher Neil J., Hoenekopp Albert, Blakesley Rick E., Larson Richard A., Hughes Timothy P.

    LANCET ONCOLOGY   12 ( 9 )   841 - 851   2011.09( ISSN:1470-2045

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    DOI: 10.1016/S1470-2045(11)70201-7

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  • Membranous nephropathy with nephrotic syndrome developed after allogeneic hematopoietic stem cell transplantation for acute lymphoblastic leukemia Reviewed

    AIMOTO Mizuki, YAMANE Takahisa, ICHII Mitsuru, MORI Katsuhito, MORIGUCHI AIMOTO Ran, WADA INOUE Eri, KOH Hideo, NAKANE Takahiko, TAKEOKA Yasunobu, AKAHORI NAKAMAE Mika, NISHIKI KOSAKA Saori, TERADA Yoshiki, NAKAMAE Hirohisa, KOH Ki-Ryang, NAKAO Takafumi, OHSAWA Masahiko, WAKASA Kenichi, ISHIMURA Eiji, INABA Masaaki, HINO Masayuki

    The Japanese Society of Hematology, Rinsho Ketsueki   52 ( 7 )   556 - 562   2011.07( ISSN:04851439

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    A 38-year-old man was diagnosed with acute lymphoblastic leukemia. We performed myeloablative bone marrow transplantation from an unrelated donor during the patient's first complete remission. After engraftment, he developed acute graft-versus-host disease involving the gastrointestinal tract on day 32. Steroids and mycophenolate mofetil were initiated from day 39. His symptoms improved and the dose of immunosuppressants was tapered and then discontinued on day 421. On day 491, he developed nephrotic syndrome (NS). Based on renal biopsy, membranous nephropathy was diagnosed. There were no apparent symptoms or abnormal laboratory data suggestive of chronic graft-versus-host disease (cGVHD). Steroid therapy was initiated from day 518 and proteinuria improved significantly. NS is very rare following allogeneic hematopoietic stem cell transplantation (allo-HSCT). When there is no concomitant cGVHD, as in this case, allo-HSCT-associated NS is difficult to distinguish from idiopathic NS.

    DOI: 10.11406/rinketsu.52.556

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  • [Membranous nephropathy with nephrotic syndrome developed after allogeneic hematopoietic stem cell transplantation for acute lymphoblastic leukemia]. Reviewed

    Aimoto M, Yamane T, Ichii M, Mori K, Moriguchi-Aimoto R, Wada-Inoue E, Koh H, Nakane T, Takeoka Y, Akahori-Nakamae M, Nishiki-Kosaka S, Terada Y, Nakamae H, Koh KR, Nakao T, Ohsawa M, Wakasa K, Ishimura E, Inaba M, Hino M

    [Rinsho ketsueki] The Japanese journal of clinical hematology   52 ( 7 )   556 - 62   2011.07( ISSN:0485-1439

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  • 同種造血幹細胞移植後に膜性腎症によるネフローゼ症候群を発症した急性リンパ性白血病 Reviewed

    相本 瑞樹, 山根 孝久, 一居 充, 森 克仁, 相本 蘭, 井上 恵里, 康 秀男, 中根 孝彦, 武岡 康信, 中前 美佳, 小坂 さおり, 寺田 芳樹, 中前 博久, 高 起良, 中尾 隆文, 大澤 政彦, 若狭 研一, 石村 栄治, 稲葉 雅章, 日野 雅之

    (一社)日本血液学会-東京事務局 臨床血液   52 ( 7 )   556 - 562   2011.07( ISSN:0485-1439

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    症例は38歳男性。急性リンパ性白血病(第一寛解期)に対して骨髄破壊的非血縁者間骨髄移植を行った。生着確認後,移植後第32病日に上部消化管の急性移植片対宿主病を発症し,第39病日よりステロイド及びmycophenolate mofetil投与を開始した。症状が改善したため,免疫抑制剤を漸減,第421病日に全ての免疫抑制剤を中止した。第491病日にネフローゼ症候群を発症,腎生検にて膜性腎症と診断した。この間,慢性移植片対宿主病を疑わせる症状,臨床検査値異常は認められなかった。第518病日よりステロイドの投与を開始したところ,尿蛋白は著明に改善した。同種造血幹細胞移植後のネフローゼ症候群は非常に稀であり,本症例のように慢性移植片対宿主病を伴わない場合は特発性ネフローゼ症候群との鑑別は困難である。(著者抄録)

  • Chronic myelogenous leukemia complicated by drug-induced agranulocytosis Reviewed

    NAKAO Takafumi, YOSHIDA Noriko, NAKANE Takahiko, TERADA Yoshiki, NAKAMAE Hirohisa, KOH Ki-Ryang, YAMANE Takahisa, HINO Masayuki

    The Japanese journal of clinical hematology   52 ( 5 )   278 - 281   2011.05( ISSN:04851439

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  • Nilotinib as frontline therapy for patients with newly diagnosed Ph+ chronic myeloid leukemia in chronic phase : results from the Japanese subgroup of ENESTnd Reviewed

    NAKAMAE Hirohisa, SHIBAYAMA Hirohiko, KUROKAWA Mineo, FUKUDA Tetsuya, NAKASEKO Chiaki, KANDA Yoshinobu, NAGAI Tadashi, OHNISHI Kazunori, MAEDA Yasuhiro, MATSUDA Akira, AMAGASAKI Taro, YANADA Masamitsu

    International journal of hematology   93 ( 5 )   624 - 632   2011.05( ISSN:09255710

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  • Nilotinib as frontline therapy for patients with newly diagnosed Ph plus chronic myeloid leukemia in chronic phase: results from the Japanese subgroup of ENESTnd Reviewed

    Nakamae Hirohisa, Shibayama Hirohiko, Kurokawa Mineo, Fukuda Tetsuya, Nakaseko Chiaki, Kanda Yoshinobu, Nagai Tadashi, Ohnishi Kazunori, Maeda Yasuhiro, Matsuda Akira, Amagasaki Taro, Yanada Masamitsu

    INTERNATIONAL JOURNAL OF HEMATOLOGY   93 ( 5 )   624 - 632   2011.05( ISSN:0925-5710

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    DOI: 10.1007/s12185-011-0841-8

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  • [Chronic myelogenous leukemia complicated by drug-induced agranulocytosis]. Reviewed

    Nakao T, Yoshida N, Nakane T, Terada Y, Nakamae H, Koh KR, Yamane T, Hino M

    [Rinsho ketsueki] The Japanese journal of clinical hematology   52 ( 5 )   278 - 81   2011.05( ISSN:0485-1439

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    PubMed

  • 新たに診断されたPh+慢性骨髄性白血病患者の慢性期におけるニロチニブによる第一線の治療法 新たに診断された日本人患者におけるニロチニブの有効性と安全性評価の成績(Nilotinib as frontline therapy for patients with newly diagnosed Ph+ chronic myeloid leukemia in chronic phase: results from the Japanese subgroup of ENESTnd) Reviewed

    Nakamae Hirohisa, Shibayama Hirohiko, Kurokawa Mineo, Fukuda Tetsuya, Nakaseko Chiaki, Kanda Yoshinobu, Nagai Tadashi, Ohnishi Kazunori, Maeda Yasuhiro, Matsuda Akira, Amagasaki Taro, Yanada Masamitsu

    (一社)日本血液学会 International Journal of Hematology   93 ( 5 )   624 - 632   2011.05( ISSN:0925-5710

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    第3相ENESTnd(Evaluating Nilotinib Efficacy and Safety in Clinical Trials-Newly Diagnosed Patient)研究の最近の知見として、慢性期のフィラデルフィア染色体陽性慢性骨髄性白血病患者(CML-CP)の治療において、ニロチニブ(NT)はイマチニブ(IM)より優れていることが示された。日本人集団の成績が全体集団のそれと一致するかどうか評価した。日本人患者79例をランダムにNT300mgまたは400mgを1日2回投与、またはIM400mgを1日1回投与の3群に分け、各群の12ヵ月時点での分子遺伝学的緩解率(MRR)を比較した。NT群のMRRはIM群の2倍以上高く、日本人集団においても全体集団と同様の成績であった。NT300mgの1日2回投与が新規CML-CPにおいても支持される。

  • 薬剤性無顆粒球症を発症した慢性骨髄性白血病 Reviewed

    中尾 隆文, 吉田 典子, 中根 孝彦, 寺田 芳樹, 中前 博久, 高 起良, 山根 孝久, 日野 雅之

    (一社)日本血液学会-東京事務局 臨床血液   52 ( 5 )   278 - 281   2011.05( ISSN:0485-1439

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    症例は75歳,女性。2000年5月に慢性骨髄性白血病の慢性期と診断,2001年の12月よりイマチニブの投与を受けていた。2007年の8月に発熱が見られたため当院外来を受診したところ,血液検査にて白血球数が600/μl(好中球0%)と低下しており,骨髄では顆粒球系細胞が著減していたため無顆粒球症と診断。受診当日より入院となり,抗生剤とG-CSF製剤の投与を受け症状は軽快した。G-CSF製剤の投与による慢性骨髄性白血病の芽球の増加は認められなかった。無顆粒球症は発熱の約2週間前に受けた下部消化管内視鏡検査の前投薬(臭化ブチルスコポラミン,フルマゼニル)によって引き起こされた可能性が高いと考えられた。慢性骨髄性白血病症例における無顆粒症の合併は非常にまれであるので,ここに報告する。(著者抄録)

  • Factors that contribute to long-term survival in patients with leukemia not in remission at allogeneic hematopoietic cell transplantation Reviewed

    Koh Hideo, Nakamae Hirohisa, Hagihara Kiyoyuki, Nakane Takahiko, Manabe Masahiro, Hayashi Yoshiki, Nishimoto Mitsutaka, Umemoto Yukari, Nakamae Mika, Hirose Asao, Inoue Eri, Inoue Atsushi, Yoshida Masahiro, Bingo Masato, Okamura Hiroshi, Aimoto Ran, Aimoto Mizuki, Terada Yoshiki, Koh Ki-Ryang, Yamane Takahisa, Ohsawa Masahiko, Hino Masayuki

    JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH   30   36   2011.04( ISSN:1756-9966

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    DOI: 10.1186/1756-9966-30-36

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  • Reduced-intensity conditioning by fludarabine/busulfan without additional irradiation or T-cell depletion leads to low non-relapse mortality in unrelated bone marrow transplantation Reviewed

    NAKANE Takahiko, NAKAMAE Hirohisa, KOH Hideo, NAKAMAE Mika, HAYASHI Yoshiki, NISHIMOTO Mitsutaka, YOSHIMURA Takuro, INOUE Eri, INOUE Atsushi, AIMOTO Ran, AIMOTO Mizuki, TERADA Yoshiki, KOH Ki-Ryang, YAMANE Takahisa, HINO Masayuki

    International journal of hematology   93 ( 4 )   509 - 516   2011.04( ISSN:09255710

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    CiNii Article

  • Reduced-intensity conditioning by fludarabine/busulfan without additional irradiation or T-cell depletion leads to low non-relapse mortality in unrelated bone marrow transplantation Reviewed

    Nakane Takahiko, Nakamae Hirohisa, Koh Hideo, Nakamae Mika, Hayashi Yoshiki, Nishimoto Mitsutaka, Yoshimura Takuro, Inoue Eri, Inoue Atsushi, Aimoto Ran, Aimoto Mizuki, Terada Yoshiki, Koh Ki-Ryang, Yamane Takahisa, Hino Masayuki

    INTERNATIONAL JOURNAL OF HEMATOLOGY   93 ( 4 )   509 - 516   2011.04( ISSN:0925-5710

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    DOI: 10.1007/s12185-011-0805-z

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  • 非血縁者間骨髄移植における追加的放射線照射およびT細胞除去を伴わないフルダラビン/ブスルファンによる骨髄非破壊的前処置は無再発死亡率を低下させる(Reduced-intensity conditioning by fludarabine/busulfan without additional irradiation or T-cell depletion leads to low non-relapse mortality in unrelated bone marrow transplantation) Reviewed

    Nakane Takahiko, Nakamae Hirohisa, Koh Hideo, Nakamae Mika, Hayashi Yoshiki, Nishimoto Mitsutaka, Yoshimura Takuro, Inoue Eri, Inoue Atsushi, Aimoto Ran, Aimoto Mizuki, Terada Yoshiki, Koh Ki-Ryang, Yamane Takahisa, Hino Masayuki

    (一社)日本血液学会 International Journal of Hematology   93 ( 4 )   509 - 516   2011.04( ISSN:0925-5710

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    全身照射(TBI)およびT細胞除去を行わない、フルダラビンとブスルファンによる前処置に続く骨髄を用いた非血縁ドナーからの骨髄非破壊的同種幹細胞移植(u-RIST)の成績を報告した。患者31名(年齢中央値53歳)をレトロスペクティブに検討した。25名(81%)はHLA-A、-Bおよび-DRB1アレル一致ドナーから移植された。全例で好中球生着が確認された。グレードII〜IVの急性GVHDの発現率は42%であった。急性GVHD患者の77%は初回の高用量ステロイド全身投与のみで改善した。2年全生存率および無再発生存率はそれぞれ62%、53%であった。2年間の無再発死亡率は10%と、比較的低かった。ある患者集団においてTBIおよびT細胞除去を用いないu-RISTは移植の予後を改善する。

  • Chronic myelogenous leukemia complicated by drug-induced agranulocytosis Reviewed

    NAKAO Takafumi, YOSHIDA Noriko, NAKANE Takahiko, TERADA Yoshiki, NAKAMAE Hirohisa, KOH Ki-Ryang, YAMANE Takahisa, HINO Masayuki

    The Japanese Society of Hematology, Rinsho Ketsueki   52 ( 5 )   278 - 281   2011

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    We describe a patient with chronic myelogenous leukemia (CML) who developed drug-induced agranulocytosis. A 75-year-old female was diagnosed with CML in December 2001. She had been receiving imatinib therapy for more than five years. In August 2007, she was hospitalized due to a severe neutropenia 10 days after colonoscopy. She was diagnosed as having agranulocytosis induced by colonoscopy premedication including scopolamine butylbromide and flumazenil. Severe neutropenia was resolved by G-CSF treatment without CML progression. Agranulocytosis in patients with CML is rare, but potentially lethal. Here, we report the clinical course in this patient.

    DOI: 10.11406/rinketsu.52.278

    CiNii Article

  • Epstein-Barr virus-associated post-transplant lymphoproliferative disorder diagnosed by the episode of intestinal perforation following allogeneic hematopoietic stem cell transplantation Reviewed

    AIMOTO Mizuki, YAMANE Takahisa, INOUE Atushi, MOMOSE Dai, MORIGUCHI AIMOTO Ran, WADA INOUE Eri, OKAMOTO Syuuichirou, KOH Hideo, NAKANE Takahiko, TAKEOKA Yasunobu, AKAHORI NAKAME Mika, NISHIKI KOSAKA Saori, TERADA Yoshiki, NAKAMAE Hirohisa, KOH Ki-Ryang, NAKAO Takafumi, OHSAWA Masahiko, HINO Masayuki

    The Japanese journal of clinical hematology   51 ( 12 )   1775 - 1780   2010.12( ISSN:04851439

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  • [Epstein-Barr virus-associated post-transplant lymphoproliferative disorder diagnosed by the episode of intestinal perforation following allogeneic hematopoietic stem cell transplantation]. Reviewed

    Aimoto M, Yamane T, Inoue A, Momose D, Moriguchi-Aimoto R, Wada-Inoue E, Okamoto S, Koh H, Nakane T, Takeoka Y, Akahori-Nakamae M, Nishiki-Kosaka S, Terada Y, Nakamae H, Koh KR, Nakao T, Ohsawa M, Hino M

    [Rinsho ketsueki] The Japanese journal of clinical hematology   51 ( 12 )   1775 - 80   2010.12( ISSN:0485-1439

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  • Cytosine-arabinoside Stimulates the Capablity of Human Marrow Stromal Cells to Support Normal Hematopoiesis Reviewed

    Li HongZhang, Koh Ki-Ryang, Toramoto Takuya, Nakamae Hirohisa, Yamane Takahisa, Ohta Kensuke, Hino Masayuki

    大阪市立大学 Osaka City Medical journal   56 ( 2 )   11 - 20   2010.12( ISSN:00306096

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  • Cytosine-arabinoside stimulates the capability of human marrow stromal cells to support normal hematopoiesis. Reviewed

    Li H, Koh KR, Toramoto T, Nakamae H, Yamane T, Ohta K, Hino M

    Osaka city medical journal   56 ( 2 )   11 - 20   2010.12( ISSN:0030-6096

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  • 同種造血幹細胞移植後の小腸穿孔で診断されたEpstein-Barr virus関連移植後リンパ増殖性疾患 Reviewed

    相本 瑞樹, 山根 孝久, 井上 敦司, 百瀬 大, 相本 蘭, 井上 恵里, 岡本 秀一郎, 康 秀男, 中根 孝彦, 武岡 康信, 中前 美佳, 小坂 さおり, 寺田 芳樹, 中前 博久, 高 起良, 中尾 隆文, 大澤 政彦, 日野 雅之

    (一社)日本血液学会-東京事務局 臨床血液   51 ( 12 )   1775 - 1780   2010.12( ISSN:0485-1439

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    症例は64歳男性。非寛解急性骨髄性白血病を化学療法により腫瘍量減量させた後に骨髄非破壊的同種骨髄移植を行った。生着確認後,移植後第42病日に消化管急性移植片対宿主病を発症,ステロイド投与を開始した。その後下痢の一時的な再燃はあったものの徐々に改善傾向がみられ,ステロイドを漸減した。第159病日に突然左下腹部痛を訴え,CTにて消化管穿孔と診断し回腸切除を施行した。術中所見では小腸の所々に潰瘍による硬結があり,潰瘍の一つに穿孔認めた。病理診断にて潰瘍部の腸管壁全層にN/C比の高い異型細胞のびまん性増殖認め,CD20およびEpstein-Barr-virus(EBV) encoded RNA陽性より同種造血幹細胞移植後のEBV関連移植後リンパ増殖性疾患と診断した。免疫抑制剤減量とrituximab投与により完全寛解となった。同種造血幹細胞移植後のEBV関連移植後リンパ増殖性疾患は比較的少なく,本症例のように消化管穿孔で発症する例は極めて稀である。(著者抄録)

  • Cytosine-arabinosideはヒト骨髄間質細胞の正常な造血を補助する能力を高める(Cytosine-arabinoside Stimulates the Capability of Human Marrow Stromal Cells to Support Normal Hematopoiesis) Reviewed

    Li Hong Zhang, Koh Ki-Ryang, Toramoto Takuya, Nakamae Hirohisa, Yamane Takahisa, Ohta Kensuke, Hino Masayuki

    大阪市医学会 Osaka City Medical Journal   56 ( 2 )   11 - 20   2010.12( ISSN:0030-6096

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    急性白血病(AL)治療に重要な薬剤であるcytosine arabinoside(Ara-C)がヒト非白血病骨髄間質細胞に及ぼす直接的活性を、Ara-Cが遺伝子発現に及ぼす影響を解析して調べた。間質細胞は、骨髄中に腫瘍性造血前駆細胞が含まれない患者11名から樹立した。細胞は、Ara-Cで1週間処理し、同種CD34陽性細胞と共培養し、細胞の支持的機能を評価する目的でcolony assay法を行った。間質細胞内の遺伝子発現においてAra-Cに誘発された変化を明らかにするため、ゲノムワイドDNAマイクロアレイ解析を行った。Ara-Cによる間質細胞の処理により、用量依存的に細胞の支持的機能が増加した。これらの作用は、CD34陽性細胞との共培養初期より晩期の方が顕著であったことから、Ara-Cで処理した間質細胞が、方向づけられた前駆細胞よりもむしろ極めて未熟な細胞を支えていることが示唆された。さらに、DNAマイクロアレイによる遺伝子発現プロファイリングの結果、コロニー刺激因子1受容体(CSF-1R)の下方調節と同時に、形質転換増殖因子βスーパーファミリーの分岐メンバーである成長分化因子15(GDF15)の著しい上方調節が判明し、どちらも主にマクロファージ上に発現した。骨髄微小環境におけるマクロファージの機能を調整することによって、未熟な造血細胞の成長を支える間質細胞の能力をAra-Cが直接高めることが示された。骨髄微小環境におけるAra-Cのこの新たな作用は、ALに対する化学療法の理解と管理の向上に寄与する可能性が示唆された。

  • Prognostic factors and outcomes of adult patients with acute myeloid leukemia after first relapse Reviewed

    Kurosawa Saiko, Yamaguchi Takuhiro, Miyawaki Shuichi, Uchida Naoyuki, Sakura Toru, Kanamori Heiwa, Usuki Kensuke, Yamashita Takuya, Okoshi Yasushi, Shibayama Hirohiko, Nakamae Hirohisa, Mawatari Momoko, Hatanaka Kazuo, Sunami Kazutaka, Shimoyama Manabu, Fujishima Naohito, Maeda Yoshinobu, Miura Ikuo, Takaue Yoichi, Fukuda Takahiro

    HAEMATOLOGICA-THE HEMATOLOGY JOURNAL   95 ( 11 )   1857 - 1864   2010.11( ISSN:0390-6078

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    DOI: 10.3324/haematol.2010.027516

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  • 同種造血幹細胞移植後のリポソーマルアムホテリシンB投与中に新規発症したトリコスポロン血症の一例 Reviewed

    康 秀男, 井上 恵里, 中根 孝彦, 武岡 康信, 相本 蘭, 相本 瑞樹, 寺田 芳樹, 中前 博久, 高 起良, 山根 孝久, 大澤 政彦, 日野 雅之

    (株)医薬ジャーナル社 血液フロンティア   20 ( 12 )   2176 - 2179   2010.11( ISSN:1344-6940

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    63歳女。骨髄異形成症候群からの急性骨髄性白血病と診断され、化学療法で寛解後に非血縁骨髄移植を施行したが骨髄再発した。再寛解導入療法を施行し、第2寛解後に再度非血縁骨髄移植を施行した。day28に好中球生着を確認したが、day32以降にアデノウイルスによる出血性膀胱炎およびウイルス血症、サイトメガロウイルス抗原血症、腎出血を発症し、ribavirin、gancyclovir、血小板輸血などを使用した。day83にCRP高値が続き、liposomal amphoptericin B(L-AMB)を5mg/kg/dayに変更した。いったん改善したが、day104より発熱が出現し、β-Dグルカン著明上昇を認め、静脈血液培養で酵母様真菌が検出され、後日Trichosporon spp.と判明した。day108よりvoriconazole 400mg/dayとmicafungin 300mg/dayの点滴に変更したところ、翌日には解熱し、β-Dグルカンも減少し、血液培養陰性を確認した。しかし、day 122より再び発熱し、翌日Stenotrophomonas maltophilia敗血症で死亡した。

  • [A modified myeloablative conditioning regimen for allogeneic hematopoietic stem cell transplantation, consisting of intravenous busulfan, cyclophosphamide and total lymphoid irradiation, in advanced leukemia]. Reviewed

    Nakamae H, Terada Y, Nakane T, Koh H, Nakamae M, Aimoto R, Hirose A, Hayashi Y, Nishimoto M, Inoue E, Yoshimura T, Inoue A, Koh KR, Yamane T, Hino M

    Gan to kagaku ryoho. Cancer & chemotherapy   37 ( 9 )   1691 - 5   2010.09( ISSN:0385-0684

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  • 同種骨髄移植後の内臓播種性水痘帯状疱疹ウイルス感染症に合併した血球貪食症候群の診断に血清フェリチンが有用であった1例 Reviewed

    宮本 奈津子, 康 秀男, 中根 孝彦, 和田 恵里, 相本 瑞樹, 相本 蘭, 武岡 康信, 寺田 芳樹, 中前 博久, 高 起良, 山根 孝久, 大澤 政彦, 日野 雅之

    (株)診断と治療社 診断と治療   98 ( 9 )   1539 - 1542   2010.09( ISSN:0370-999X

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    24歳女。急性骨髄性白血病にて骨髄移植を受けたが再発し、再移植目的で入院となった。同種増血幹細胞移植を受け寛解状態であったが、下剤抵抗性の便秘、上腹部痛が出現し、更には汎血球減少、肝逸脱酵素の上昇、フェリチン高値を認めた。骨髄検査を行ったが、血球貪食像は認めなかった。その後、全身に散在性の水疱が出現したためアシクロビル投与を開始したが、翌日に血球減少の進行、肝逸脱酵素、フェリチンの急激な上昇を認めた。高熱なく、診断基準を十分に満たしていなかったが血球貪食症候群と診断し、メチルプレドニゾロンを追加したところ、翌日より肝機能、フェリチン値ともに改善を認めた。後日、皮疹の生検で巨細胞を認め、VZV-DNA高値であり、内臓播種性水痘帯状疱疹ウイルス感染症と確定診断した。ウイルス量は次第に減少し、難治性であった腹痛も改善して退院となった。

  • 進行期白血病に対する静注Busulfan(Busulfex)+Cyclophosphamide+Total Lymphoid Irradiationを用いたModified Myeloablative Conditioningによる同種造血幹細胞移植 Reviewed

    中前 博久, 寺田 芳樹, 中根 孝彦, 康 秀男, 中前 美佳, 相本 蘭, 廣瀬 朝生, 林 良樹, 西本 光孝, 井上 恵里, 吉村 卓朗, 井上 敦司, 高 起良, 山根 孝久, 日野 雅之

    (株)癌と化学療法社 癌と化学療法   37 ( 9 )   1691 - 1695   2010.09( ISSN:0385-0684

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    同種造血幹細胞移植の移植前処置の強度の最適化を検討する目的で静注busulfan 8mg/kg+cyclophosphamide 120mg/kg+total lymphoid irradiation(TLI)7.5Gyによるmodified myeloablative conditioning regimenにて進行期の急性、慢性白血病9例に対して同種造血幹細胞移植を行った。年齢の中央値は30(18〜59)歳。造血幹細胞源は血縁骨髄2例、血縁末梢血幹細胞1例、非血縁骨髄6例。急性graft-versus-host disease(GVHD)予防はcyclosporin+短期methotrexate療法で行った。急性GVHDは9人中6例(67%)に出現し、全例でgrade 2であった。広範型慢性GVHDは評価可能症例7例中3例に認められた。移植後観察期間中央値は813(248〜1702)日で、9例中5例で移植後に原疾患の再発、再燃を認めたが、移植後100日以内の再発例はなかった。移植全観察期間を通じて移植関連死亡は認めなかった。2年の全生存率は88.9%、無病生存率は50.0%であった。今回の結果から骨髄破壊的前処置を最適化することによって、移植関連死亡を減少させると同時に病勢をコントロールし得る至適な移植前処置が存在する可能性があると考えられた。(著者抄録)

  • Dasatinib versus Imatinib in Newly Diagnosed Chronic-Phase Chronic Myeloid Leukemia Reviewed

    Kantarjian Hagop, Shah Neil P., Hochhaus Andreas, Cortes Jorge, Shah Sandip, Ayala Manuel, Moiraghi Beatriz, Shen Zhixiang, Mayer Jiri, Pasquini Ricardo, Nakamae Hirohisa, Huguet Francoise, Boque Concepcion, Chuah Charles, Bleickardt Eric, Bradley-Garelik M. Brigid, Zhu Chao, Szatrowski Ted, Shapiro David, Baccarani Michele

    NEW ENGLAND JOURNAL OF MEDICINE   362 ( 24 )   2260 - 2270   2010.06( ISSN:0028-4793

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    DOI: 10.1056/NEJMoa1002315

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  • Pilot Study of a (213)Bismuth-Labeled Anti-CD45 mAb as a Novel Nonmyeloablative Conditioning for DLA-Haploidentical Littermate Hematopoietic Transplantation Reviewed

    Nakamae Hirohisa, Kerbauy Fabio R., Wilbur D. Scott, Bethge Wolfgang, Hamlin Donald K., Santos Erlinda B., Storb Rainer, Sandmaier Brenda M.

    TRANSPLANTATION   89 ( 11 )   1336 - 1340   2010.06( ISSN:0041-1337

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    DOI: 10.1097/TP.0b013e3181d98c3d

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  • Heart rate variability during and after peripheral blood stem cell leukapheresis in autologous transplant patients and allogeneic transplant donors Reviewed

    NAKANE Takahiko, NAKAMAE Hirohisa, KOH Hideo, NAKAMAE Mika, AIMOTO Ran, TERADA Yoshiki, KOH Ki-Ryang, YAMANE Takahisa, HINO Masayuki

    International journal of hematology   91 ( 3 )   478 - 484   2010.04( ISSN:09255710

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  • Heart rate variability during and after peripheral blood stem cell leukapheresis in autologous transplant patients and allogeneic transplant donors Reviewed

    Nakane Takahiko, Nakamae Hirohisa, Koh Hideo, Nakamae Mika, Aimoto Ran, Terada Yoshiki, Koh Ki-Ryang, Yamane Takahisa, Hino Masayuki

    INTERNATIONAL JOURNAL OF HEMATOLOGY   91 ( 3 )   478 - 484   2010.04( ISSN:0925-5710

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    DOI: 10.1007/s12185-010-0543-7

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  • 自己移植患者および同種移植ドナーにおける末梢血幹細胞白血球除去療法中および療法後の心拍変動(Heart rate variability during and after peripheral blood stem cell leukapheresis in autologous transplant patients and allogeneic transplant donors) Reviewed

    Nakane Takahiko, Nakamae Hirohisa, Koh Hideo, Nakamae Mika, Aimoto Ran, Terada Yoshiki, Koh Ki-Ryang, Yamane Takahisa, Hino Masayuki

    (一社)日本血液学会 International Journal of Hematology   91 ( 3 )   478 - 484   2010.04( ISSN:0925-5710

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    末梢血幹細胞採取(PBSCH)時には種々の合併症がみられ、致死的な合併症も報告されている。交感神経のバランスおよび心血管の自律性調節を反映する心拍変動(HRV)は突然死を引き起こす種々の疾患で非常に興味が持たれている。自己造血幹細胞移植患者および健常ドナーでHRVに及ぼす白血球除去療法の影響をプロスペクティブに評価した。その結果、洞調律R-R間隔の標準偏差(SDNN)、連続した洞調律RR間隔の差の自乗の平均値の平方根(r-MSSD)、総周波数(TF)、高周波数および低周波数(LF)パワーが白血球除去療法中有意に低下し、病的レベルになった。SDNN、TFおよびLFパワーの病的変化は白血球除去療法後6〜9時間持続した。白血球除去療法前のTFおよびLFパワーは症候性低血圧患者の方が他の患者に比べて有意に低かった。HRV分析はPBSCHにおける心血管系合併症の評価および予測に使用できると思われた。

  • Low-dose total body irradiation and fludarabine conditioning for HLA class I-mismatched donor stem cell transplantation and immunologic recovery in patients with hematologic malignancies: a multicenter trial. Reviewed

    Nakamae H, Storer BE, Storb R, Storek J, Chauncey TR, Pulsipher MA, Petersen FB, Wade JC, Maris MB, Bruno B, Panse J, Petersdorf E, Woolfrey A, Maloney DG, Sandmaier BM

    Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation   16 ( 3 )   384 - 94   2010.03( ISSN:1083-8791

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    DOI: 10.1016/j.bbmt.2009.11.004

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  • Epstein-Barr virus-associated post-transplant lymphoproliferative disorder diagnosed by the episode of intestinal perforation following allogeneic hematopoietic stem cell transplantation Reviewed

    AIMOTO Mizuki, YAMANE Takahisa, INOUE Atushi, MOMOSE Dai, MORIGUCHI-AIMOTO Ran, WADA-INOUE Eri, OKAMOTO Syuuichirou, KOH Hideo, NAKANE Takahiko, TAKEOKA Yasunobu, AKAHORI-NAKAMAE Mika, NISHIKI-KOSAKA Saori, TERADA Yoshiki, NAKAMAE Hirohisa, KOH Ki-Ryang, NAKAO Takafumi, OHSAWA Masahiko, HINO Masayuki

    The Japanese Society of Hematology, Rinsho Ketsueki   51 ( 12 )   1775 - 1780   2010( ISSN:0485-1439

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    A 64-year-old man was diagnosed as having acute myeloid leukemia. We performed sequential treatment with chemotherapy and reduced-intensity stem cell transplantation from an unrelated donor while the patient was in partial remission. After engraftment, he developed acute graft-versus-host disease of the gut on day 42 and steroid therapy was started. Despite transient aggravation of diarrhea, his symptoms slowly improved and the dose of steroid was tapered. On day 159, he complained of acute left lower abdominal pain. A CT scan showed perforation of the digestive tract and ileectomy was performed. At surgery, multiple ulcers of the intestine were found and one of the ulcers was perforated. Pathologically, transmural and diffuse proliferation of atypical cells in the ulcer were confirmed. Since these cells were positive for CD20 and Epstein-Barr-virus (EBV) encoded RNA, we made a diagnosis of EBV-associated post-transplant lymphoproliferative disorder (PTLD). Reduction in the dose of immunosuppressive agents and rituximab led to complete remission of PTLD. PTLD after allogeneic hematopoietic stem cell transplantation (allo-HSCT) is relatively rare, and the development of gastrointestinal perforation after allo-HSCT is very rare.

    DOI: 10.11406/rinketsu.51.1775

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  • Serum Cytokine Profiles at the Onset of Severe, Diffuse Alveolar Hemorrhage Complicating Allogeneic Hematopoietic Stem Cell Transplantation, Treated Successfully with Pulse Intravenous Cyclophosphamide Reviewed

    Koh Hideo, Nakamae Hirohisa, Koh Ki-Ryang, Ohsawa Masahiko, Nakane Takahiko, Takeoka Yasunobu, Aimoto Ran, Aimoto Mizuki, Wada-Inoue Eri, Terada Yoshiki, Yamane Takahisa, Hino Masayuki

    ACTA HAEMATOLOGICA   124 ( 3 )   171 - 175   2010( ISSN:0001-5792

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    DOI: 10.1159/000318013

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  • Reagents for astatination of biomolecules. 4. Comparison of maleimido-closo-decaborate(2-) and meta-[(211)At]astatobenzoate conjugates for labeling anti-CD45 antibodies with [(211)At]astatine. Reviewed

    Wilbur DS, Thakar MS, Hamlin DK, Santos EB, Chyan MK, Nakamae H, Pagel JM, Press OW, Sandmaier BM

    Bioconjugate chemistry   20 ( 10 )   1983 - 91   2009.10( ISSN:1043-1802

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    DOI: 10.1021/bc9000799

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  • Cardiac and autonomic nerve function after reduced-intensity stem cell transplantation for hematologic malignancy in patients with pre-transplant cardiac dysfunction Reviewed

    Nakane Takahiko, Nakamae Hirohisa, Muro Takashi, Yamagishi Hiroyuki, Kobayashi Yoshiki, Aimoto Mizuki, Sakamoto Erina, Terada Yoshiki, Nakamae Mika, Koh Ki-Ryang, Yamane Takahisa, Yoshiyama Minoru, Hino Masayuki

    ANNALS OF HEMATOLOGY   88 ( 9 )   871 - 879   2009.09( ISSN:0939-5555

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    DOI: 10.1007/s00277-009-0695-9

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  • Impact of relative dose intensity (RDI) in CHOP combined with rituximab (R-CHOP) on survival in diffuse large B-cell lymphoma Reviewed

    Terada Yoshiki, Nakamae Hirohisa, Aimoto Ran, Kanashima Hiroshi, Sakamoto Erina, Aimoto Mizuki, Inoue Eri, Koh Hideo, Nakane Takahiko, Takeoka Yasunobu, Ohsawa Masahiko, Koh Ki-Ryang, Yamane Takahisa, Nakao Yoshitaka, Ohta Kensuke, Mugitani Atsuko, Teshima Hirofumi, Hino Masayuki

    JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH   28   116   2009.08( ISSN:1756-9966

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    DOI: 10.1186/1756-9966-28-116

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  • Effect of conditioning regimen intensity on CMV infection in allogeneic hematopoietic cell transplantation. Reviewed

    Nakamae H, Kirby KA, Sandmaier BM, Norasetthada L, Maloney DG, Maris MB, Davis C, Corey L, Storb R, Boeckh M

    Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation   15 ( 6 )   694 - 703   2009.06( ISSN:1083-8791

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    DOI: 10.1016/j.bbmt.2009.02.009

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  • Biodistributions, myelosuppression, and toxicities in mice treated with an anti-CD45 antibody labeled with the alpha-emitting radionuclides bismuth-213 or astatine-211. Reviewed

    Nakamae H, Wilbur DS, Hamlin DK, Thakar MS, Santos EB, Fisher DR, Kenoyer AL, Pagel JM, Press OW, Storb R, Sandmaier BM

    Cancer research   69 ( 6 )   2408 - 15   2009.03( ISSN:0008-5472

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    DOI: 10.1158/0008-5472.CAN-08-4363

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  • Chronic myeloid leukemia in two patients with gastrointestinal stromal tumor Reviewed

    SAKAMOTO Erina, SAWADA Tetsuji, OSUGI Harushi, NAKAMAE Hirohisa, KOH Ki-Ryang, YAMANE Takahisa, OHSAWA Masahiko, WAKASA Kenichi, HINO Masayuki

    International journal of hematology   88 ( 3 )   348 - 350   2008.10( ISSN:09255710

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  • Prognostic value of serum surfactant protein D level prior to transplant for the development of bronchiolitis obliterans syndrome and idiopathic pneumonia syndrome following allogeneic hematopoietic stem cell transplantation Reviewed

    Nakane T., Nakamae H., Kamoi H., Koh H., Takeoka Y., Sakamoto E., Kanashima H., Nakamae M., Ohta K., Terada Y., Koh K-R, Yamane T., Hino M.

    BONE MARROW TRANSPLANTATION   42 ( 1 )   43 - 49   2008.07( ISSN:0268-3369

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    DOI: 10.1038/bmt.2008.73

  • Hematopoietic cell transplantation and clinical chemistry Reviewed

    HINO Masayuki, NAKAMAE Hirohisa, KOH Ki-ryang, YAMANE Takahisa

    37 ( 2 )   107 - 115   2008.04( ISSN:03705633

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  • Hematopoietic cell transplantation and clinical chemistry Reviewed

    Hino Masayuki, Nakamae Hirohisa, Koh Ki-ryang, Yamane Takahisa

    Japan Society of Clinical Chemistry, Ikagaku Shinpojumu   37 ( 2 )   107 - 115   2008( ISSN:0370-5633

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    DOI: 10.14921/jscc1971b.37.2_107

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  • Possible involvement of gamma delta-t cells in the development of chronic graft-versus-host disease after allogeneic hematopoietic stem cell transplantation Reviewed

    Koh Ki-Ryang, Nakamae Hirohisa, Ohta Kensuke, Li Hongzhang, Koh Hideo, Nakane Takahiko, Takeoka Yasunobu, Hirose Asao, Hagihara Kiyoyuki, Sakamoto Erina, Nakamae Mika, Terada Yoshiki, Yamane Takahisa, Hino Masayuki

    BLOOD   110 ( 11 )   586A - 587A   2007.11( ISSN:0006-4971

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  • The impact of relative dose intensity (RDI) of CHOP on outcome of diffuse large B-cell lymphoma: Results of a single center study Reviewed

    Terada Yoshiki, Nakamae Hirohisa, Nakane Takahiko, Koh Hideo, Takeoka Yasunobu, Moriguchi Ran, Aimoto Mizuki, Akazawa Yuki, Wada Eri, Kanashima Hiroshi, Sakamoto Erma, Koh Ki-Ryang, Yamane Takahisa, Ohta Kensuke, Nakao Yoshitaka, Teshima Hirofumi, Hino Masayuki

    BLOOD   110 ( 11 )   184B - 184B   2007.11( ISSN:0006-4971

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  • Necrotizing fasciitis caused by Staphylococcus aureus in chronic myeloproliferative disease

    61 ( 7 )   558 - 561   2007.06( ISSN:00214973

  • [Improved outcome in brain abscess during induction in acute myelocytic leukemia]. Reviewed

    Nakane T, Yamane T, Nakamae H, Ichihara H, Koh H, Takeoka Y, Kanashima H, Sakamoto E, Koh KR, Hino M

    Gan to kagaku ryoho. Cancer & chemotherapy   34 ( 5 )   789 - 92   2007.05( ISSN:0385-0684

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  • Allogeneic hematopoietic stem cell transplantation for adult T cell leukemia: Result of a single center study Reviewed

    Koh Hideo H., Koh Ki-Ryang K., Hagihara Kiyoyuki K., Nakane Takahiko K., Takeoka Yasunobu K., Kanashima Hiroshi K., Sakamoto Erina K., Nakamae Mika K., Ichihara Hiroyoshi K., Terada Yoshiki K., Nakamae Hirohisa K., Ohta Kensuke K., Yamane Takahisa K., Watanabe Toshiki K., Hino Masayuki K.

    AIDS RESEARCH AND HUMAN RETROVIRUSES   23 ( 4 )   604 - 605   2007.04( ISSN:0889-2229

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  • A multicentric Castleman disease-like case characterized by lymphadenopathy and polyclonal hypergammaglobulinemia associated with so-called Mikulicz disease Reviewed

    OHTA Tadanobu, FURUKAWA Yoshio, AOYAMA Yasutaka, KUMURA Takeo, MUGITANI Atsuko, NAKAMAE Hirohisa, KOH Kyron, YAMANE Takahisa, HINO Masayuki

    The Japanese Society of Hematology, Rinsho Ketsueki   48 ( 3 )   229 - 234   2007.03( ISSN:04851439

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    A 73-year-old male was admitted in January 1999 with hyperimmunoglobulinemia with a serum IgG level of 6530 mg/d<i>l</i>, bilateral eyelid tumors, bilateral submandibular swelling, and swelling of the superficial lymph nodes. A left submandibular gland biopsy showed severe chronic sialoadenitis with fibrosis. A left cervical lymph node biopsy showed invasion by many mature lymphocytes and plasma cells, but no lymphoma cells. The patient was diagnosed as having so-called Mikulicz disease associated with a disease similar to multicentric Castleman disease (MCD) characterized by multicentric lymphadenopathy and polyclonal hyperimmunoglobulinemia. Steroid therapy (prednisolone, 20 mg/day) was effective in reducing the symptoms, the bilateral eyelid tumors and the swelling of the bilateral submandibular glands and superficial lymph nodes. The lack of any increase of serum IL-6 suggested that this case had a hitherto unknown etiology, other than MCD.

    DOI: 10.11406/rinketsu.48.229

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  • [Multicentric Castleman disease-like case characterized by lymphadenopathy and polyclonal hypergammaglobulinemia associated with so-called Mikulicz disease]. Reviewed

    Ohta T, Furukawa Y, Aoyama Y, Kumura T, Mugitani A, Nakamae H, Koh K, Yamane T, Hino M

    [Rinsho ketsueki] The Japanese journal of clinical hematology   48 ( 3 )   229 - 34   2007.03( ISSN:0485-1439

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  • 妊娠により重症化した難治性特発性血小板減少性紫斑病に対して摘脾が有効であった1例 Reviewed

    市原 弘善, 山根 孝久, 康 秀男, 中根 孝彦, 武岡 康信, 坂本 恵利奈, 金島 広, 中前 博久, 高 起良, 山田 靖哉, 松本 万紀子, 橘 大介, 石河 修, 日野 雅之

    血液診療   4 ( 2 )   46 - 48   2007.02

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    36歳女。めまいを主訴に近医を受診し、特発性血小板減少性紫斑病(ITP)と診断された。出血症状は認められず、無治療で経過観察していた。妊娠第10週第3日の受診時、血小板数は5.9万であったが、次第に減少し、減少傾向を認めた。ステロイドおよびH.pylori除菌療法を施行したが無効であった。本人および配偶者が妊娠の継続・出産を希望し、ガンマグロブリン大量療法で血小板数を増加させた後に摘脾を行うこととなった。妊娠38週2日目に経腟分娩にて健児を得ることができた。

  • Two cases of ampulla (takotsubo-shaped) cardiomyopathy associated with hemophagocytic lymphohistiocytosis Reviewed

    Takeoka Yasunobu, Nakamae Mika, Nakamae Hirohisa, Hagihara Kiyoyuki, Sakamoto Erina, Nakane Takahiko, Koh Hideo, Koh Ki-Ryang, Ohta Kensuke, Yamane Takahisa, Hino Masayuki

    ACTA HAEMATOLOGICA   117 ( 4 )   205 - 210   2007( ISSN:0001-5792

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    DOI: 10.1159/000098461

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  • Myelodysplastic syndrome with cyclosporine A-induced encephalopathy presenting with a mass effect on the right basal ganglia after cord blood transplantation Reviewed

    KOH Hideo, YAMANE Takahisa, NAKANE Takahiko, TAKEOKA Yasunobu, SAKAMOTO Erina, KANASHIMA Hiroshi, NAKAMAE Mika, NAKAMAE Hirohisa, KOH Ki-ryang, MOCHIZUKI Kunizo, HAYASHI Noriko, HINO Masayuki

    The Japanese Society of Hematology, Rinsho Ketsueki   47 ( 12 )   1539 - 1543   2006.12( ISSN:04851439

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    An 18-year-old female with myelodysplastic syndrome underwent an allogeneic cord blood transplantation in May 2005. The conditioning regimen consisted of total body irradiation, cytarabine and cyclophosphamide. The day of the cord stem cell transfusion was counted as Day 0. For acute GVHD prophylaxis, cyclosporine A (CsA) and methotrexate were used. Engraftment was achieved on Day 30, acute GVHD grade II developed on Day 45 and treatment with methylprednisolone for acute GVHD was started. On Day 68 the patient had generalized seizures accompanied by loss of consciousness, hypertension and left hemiparesis, and was intubated. A cranial CT scan showed a mass effect on the right basal ganglia, and high signal intensities on the T2-weighted and FLAIR images of a MR examination were detected in the bilateral basal ganglia and posterior lobes, the findings of which were compatible with a brain tumor or infectious disease. Since an increased level of apparent diffusion coefficient (ADC) values on the bilateral basal ganglia was noted, we suspected that vasogenic edema had caused the mass effect. She went into remission immediately after CsA treatment was discontinued. Therefore, this case was diagnosed as atypical reversible posterior leukoencephalopathy syndrome (RPLS) associated with CsA. CsA-induced encephalopathy presenting a mass effect in clinical imaging findings is very rare, and an ADC map may be useful for the diagnosis of RPLS.

    DOI: 10.11406/rinketsu.47.1539

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  • [Myelodysplastic syndrome with cyclosporine A-induced encephalopathy presenting with a mass effect on the right basal ganglia after cord blood transplantation]. Reviewed

    Koh H, Yamane T, Nakane T, Takeoka Y, Sakamoto E, Kanashima H, Nakamae M, Nakamae H, Koh KR, Mochizuki K, Hayashi N, Hino M

    [Rinsho ketsueki] The Japanese journal of clinical hematology   47 ( 12 )   1539 - 43   2006.12( ISSN:0485-1439

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  • Expression of cyclooxygenase-2 in Hodgkin's lymphoma: Its role in cell proliferation and angiogenesis Reviewed

    Ohsawa Masahiko, Fukushima Hiroko, Ikura Yoshihiro, Inoue Takeshi, Shirai Nobuyuki, Sugama Yoshimi, Suekane Takehisa, Kitabayashi Chizuko, Nakamae Hirohisa, Hino Masayuki, Ueda Makiko

    LEUKEMIA & LYMPHOMA   47 ( 9 )   1863 - 1871   2006.09( ISSN:1042-8194

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    DOI: 10.1080/10428190600685442

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  • Risk factor analysis for thrombotic microangiopathy after reduced-intensity or myeloablative allogeneic hematopoietic stem cell transplantation Reviewed

    Nakamae H, Yamane T, Hasegawa T, Nakamae M, Terada Y, Hagihara K, Ohta K, Hino M

    AMERICAN JOURNAL OF HEMATOLOGY   81 ( 7 )   525 - 531   2006.07( ISSN:0361-8609

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/ajh.20648

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  • T-lymphocyte subset analysis using the automated hematology analyser CELL-DYN 4000 for patients with hematological disorders Reviewed

    Yamane T, Hagihara K, Nakamae H, Hasegawa T, Hino M

    LEUKEMIA & LYMPHOMA   47 ( 3 )   503 - 506   2006.03( ISSN:1042-8194

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    DOI: 10.1080/10428190500353612

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  • [High-dose chemotherapy with autologous hematopoietic stem cell transplantation for non-Hodgkin's lymphoma in complete response as consolidation therapy, second report]. Reviewed

    Yamane T, Hirose A, Nakajima Y, Nakane T, Koh H, Takeoka Y, Nakamae M, Yamamura R, Nakamae H, Nakao Y, Mugitani A, Yagi T, Teshima H, Hino M

    Gan to kagaku ryoho. Cancer & chemotherapy   33 ( 2 )   193 - 8   2006.02( ISSN:0385-0684

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  • Adult T-cell leukemia blast crisis in a patient with acute liver failure. Reviewed

    Kawamura E, Habu D, Kurooka H, Hayashi T, Oe A, Kotani J, Higashiyama S, Nakamae H, Torii K, Kawabe J, Shiomi S

    Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology   25 ( 1 )   49   2006.01( ISSN:0254-8860

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  • T-lymphocyte subset analysis using the automated hematology analyser CELL-DYN 4000 for patients with hematological disorders

    47 ( 3 )   503 - 506   2006

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    Publishing type:Research paper (scientific journal)   Kind of work:Single Work  

  • Notable effects of angiotensin II receptor blocker, valsartan, on acute cardiotoxic changes after standard chemotherapy with cyclophosphamide, doxorubicin, vincristine, and prednisolone Reviewed

    Nakamae H, Tsumura K, Terada Y, Nakane T, Nakamae M, Ohta K, Yamane T, Hino M

    CANCER   104 ( 11 )   2492 - 2498   2005.12( ISSN:0008-543X

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    DOI: 10.1002/cncr.21478

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  • Cord Blood Transplantation for Adult Patients with Hematological Malignancies Reviewed

    山根 孝久, 中前 博久, 長谷川 太郎 [他]

    大阪市立大学 Osaka City Medical journal   51 ( 2 )   83 - 88   2005.12( ISSN:00306096

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  • Cord blood transplantation for adult patients with hematological malignancies. Reviewed

    Yamane T, Nakamae H, Hasegawa T, Terada Y, Hagihara K, Ohta K, Hino M

    Osaka city medical journal   51 ( 2 )   83 - 8   2005.12( ISSN:0030-6096

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  • Chronic GVHD with polymyositis after non-myeloablative stem cell transplantation Reviewed

    NAKAMAE Hirohisa, HIMURO Kimihide, HAGIHARA Kiyoyuki, TERADA Yoshiki, SAKAMOTO Erina, TAKEOKA Yasunobu, NAKANE Takahiko, NAKAMAE Mika, OHTA Kensuke, YAMANE Takahisa, SHIMADA Hiroyuki, MIKI Takami, HINO Masayuki

    The Japanese Society of Hematology, Rinsho Ketsueki   46 ( 11 )   1213 - 1217   2005.11( ISSN:04851439

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    A 57-year-old man underwent an autologous hematopoietic stem cell transplant for mantle cell lymphoma in August 1999. Anemia and thrombocytopenia appeared in November 2001. He was diagnosed with further hematological examination as having acute myeloid leukemia with multilineage dysplasia following secondary myelodysplastic syndrome. He received the allogeneic hematopoietic stem cell transplant from his HLA DRB1 locus mismatched brother in May 2002. The non-myeloablative preparative regimen consisted of fludarabine 30mg/m<sup>2</sup> for 6 days and busulfan 4mg/kg for 2 days. Eosinophilia, decrease of lacrimal fluid and liver dysfunction appeared on Day 104. We diagnosed this as chronic GVHD and treated the patient with prednisolone 10 mg/day. Thereafter, his chronic GVHD gradually improved. He had fever and myalgia in the extremities and lumbar region with elevated serum CPK and aldolase in January 2003. Histological examination led to a diagnosis of polymyositis simultaneously with chronic GVHD. Prednisolone 50 mg/day as an initial dose was started for the polymyositis following which the prednisolone dose was gradually tapered off. The polymyositis improved promptly after the administration of prednisolone and remains in remission with a current maintenance program of prednisolone 5 mg/day.

    DOI: 10.11406/rinketsu.46.1213

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  • [Temporary effective treatment with L-asparaginase for a patient with refractory nasal NK/T-cell lymphoma]. Reviewed

    Sakamoto E, Yamane T, Nakane T, Takeoka Y, Hirose A, Hagihara K, Nakamae H, Ohta K, Hirayama M, Ikura Y, Ohsawa M, Sawada T, Kitoh T, Hino M

    Gan to kagaku ryoho. Cancer & chemotherapy   32 ( 12 )   1993 - 6   2005.11( ISSN:0385-0684

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    PubMed

  • [Chronic GVHD with polymyositis after non-myeloablative stem cell transplantation]. Reviewed

    Nakamae H, Himuro K, Hagihara K, Terada Y, Sakamoto E, Takeoka Y, Nakane T, Nakamae M, Ohta K, Yamane T, Shimada H, Miki T, Hino M

    [Rinsho ketsueki] The Japanese journal of clinical hematology   46 ( 11 )   1213 - 7   2005.11( ISSN:0485-1439

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    Publishing type:Research paper (scientific journal)  

    PubMed

  • [Clinical analysis of antibiotic treatment for febrile neutropenia]. Reviewed

    Shibata H, Yamane T, Sakamoto E, Nakamae H, Ohta K, Hino M

    The Japanese journal of antibiotics   58 ( 4 )   382 - 7   2005.08( ISSN:0368-2781

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    Publishing type:Research paper (scientific journal)  

    PubMed

  • [Acute myelomonocytic leukemia complicated with multiple lower intestinal ulcers induced by nonsteroidal anti-inflammatory drugs]. Reviewed

    Koh G, Yamane T, Aoyama Y, Sakamoto C, Nakamae H, Hasegawa T, Terada Y, Hino M

    Gan to kagaku ryoho. Cancer & chemotherapy   32 ( 1 )   111 - 3   2005.01( ISSN:0385-0684

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    Publishing type:Research paper (scientific journal)  

    PubMed

  • Evaluation of an automated hematology analyzer (CELL-DYN 4000) for counting CD4+ T helper cells at low concentrations Reviewed

    Hagihara K, Yamane T, Aoyama Y, Nakamae H, Hino M

    ANNALS OF CLINICAL AND LABORATORY SCIENCE   35 ( 1 )   31 - 36   2005( ISSN:0091-7370

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    Publishing type:Research paper (scientific journal)  

  • Evaluation of an automated hematology analyzer (CELL-DYN 4000) for counting CD4+ T helper cells at low concentrations

    Annals of Clinical and Laboratory Science   35 ( 1 )   31 - 36   2005

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  • Notable effects of angiotensin II receptor blocker, Valsartan, on acute cardiotoxic changes after standard chemotherapy with cyclosphamide, doxorubicin, vincristine, and prednisolone

    Cancer   104 ( 11 )   2492 - 2498   2005

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    Publishing type:Research paper (scientific journal)  

  • CLINICAL ANALYSIS OF ANTIBIOTIC TREATMENT FOR FEBRILE NEUTROPENIA Reviewed

    SHIBATA HISAKO, YAMANE TAKAHISA, SAKAMOTO ERINA, NAKAMAE HIROHISA, OHTA KENSUKE, HINO MASAYUKI

    Japan Antibiotics Research Association, The Japanese Journal of Antibiotics   58 ( 4 )   382 - 387   2005( ISSN:0368-2781

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    Publishing type:Research paper (scientific journal)  

    Patients with hematological malignancies and aplastic anemia become complicated by critical infections, which are one of the common causes of death in many cases. This is a retrospective investigation of the factors that affect the efficacy of antibiotic treatment of febrile neutropenia (FN). The subjects consisted of 98 cases that developed FN during their hospitalization in this department and received antibiotics as a first-line treatment. Parameters evaluated were age, gender, with or without administration of granulocyte-colony stimulating factor (G-CSF), with or without hematopoietic transplantation, the number of antibiotics, the type of antibiotics, the highest level of C-reactive protein (CRP), with or without antifungal prophylaxis, the duration of neutropenia, and the number of neutrophils before and after the administration of antibiotics. Logistic analysis was used for statistical evaluation. With univariate analysis, significant clinical efficacy was observed with the use of carbapenems (p=0.0009, Odds;4.58) when the number of neutrophils was not less than 500/μL (P<0.0001, Odds: 14.1) after administration of antibiotics. Furthermore, even when multivariate analysis was performed, 3ignificant clinical efficacy was observed independently in the use of carbapenems (P=0.02, Odds: 3.73) and when the number of neutrophils was not less than 500/μL (P<0.0001, Odds: 10.4) after administration of antibiotics. In this investigation, as a first-line treatment of FN, carbapenem antibiotic is recommended as a primary chaice, when the number of neutrophils was expected to decrease after administration.

    DOI: 10.11553/antibiotics1968b.58.382

    CiNii Article

  • Predictive value of QT dispersion for acute heart failure after autologous and allogeneic hematopoietic stem cell transplantation

    American Journal of Hematology   76 ( 1 )   1 - 7   2004

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  • Conditioning regimens including high-dose busulfan cause a high incidence of transplant-related mortality after myeloablative stem cell transplantation

    Chemotherapy   504 ( 4 )   178 - 183   2004

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    Publishing type:Research paper (scientific journal)  

  • QT dispersion correlates with systolic rather than diastolic parameters in patients receiving anthracycline treatment

    Internal Medicine   43 ( 5 )   379 - 387   2004

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    Publishing type:Research paper (scientific journal)  

  • A case of a long-time survivor with chronic active Epstein-Barr virus infection

    European Journal of Haematology   72 ( 1 )   73 - 76   2004

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  • Pericarditis associated with Epstein-Barr virus reactivation in a patient following allogeneic peripheral blood stem cell transplantation from an HLA Genotypic 1-locus mismatched sibling donor

    Leukemia and Lymphoma   45 ( 2 )   393 - 395   2004

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  • QT dispersion as a predictor of acute heart failure after high-dose cyclophosphamide.

    LANCET   355   805 - 806   2000

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    Publishing type:Research paper (scientific journal)  

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MISC

  • HLA一致同種造血幹細胞移植と移植後シクロホスファミド投与の系統的概観(Systematic overview of HLA-matched allogeneic hematopoietic cell transplantation with post-transplantation cyclophosphamide) International journal

    Nakamae Hirohisa

    International Journal of Hematology   116 ( 4 )   465 - 481   2022.10( ISSN:0925-5710

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    Authorship:Lead author, Corresponding author   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)   International / domestic magazine:International journal  

  • 【造血器腫瘍治療の進歩】造血幹細胞移植と細胞療法の現状と展望 同種造血幹細胞移植 Invited International journal

    中前 博久

    腫瘍内科   29 ( 4 )   462 - 468   2022.04( ISSN:1881-6568

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    Authorship:Lead author, Corresponding author   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)   International / domestic magazine:Domestic journal  

  • TMAとaHUS(第7回) 骨髄移植後TMAとaHUS

    岡村 浩史, 中前 博久

    Thrombosis Medicine   11 ( 3 )   227 - 231   2021.09( ISSN:2186-0327

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    <Points>■近年、骨髄移植後TMA(TA-TMA)の発症病態として補体経路活性化の機序が注目されており、エクリズマブを始めとした様々な抗補体薬の検討がなされている。■TA-TMAの臨床診断基準には様々なものが提案されているが、いずれの診断基準を満たす場合においても、移植予後に悪影響がある。■非典型溶血性尿毒症症候群(aHUS)は第二経路の異常活性化がその病態の本質であることが明らかにされ、エクリズマブの高い奏効率が報告されている。■aHUSとTA-TMAの病態には未だ不明な点も残されており、さらなる病態の解明と各病態に応じた病型分類、治療法の確立が望まれる。(著者抄録)

  • 【急性リンパ芽球性白血病】TKI時代におけるPh陽性急性リンパ芽球性白血病の化学療法の動向

    南野 智, 中前 博久

    血液内科   82 ( 4 )   454 - 460   2021.04( ISSN:2185-582X

  • 移植後の大量シクロホスファミドを用いたHLAハプロ一致同種造血細胞移植における今後の戦略

    中前 博久

    日本造血細胞移植学会雑誌   10 ( 1 )   48 - 57   2021.01

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    移植後大量シクロホスファミドを用いたHLA半合致血縁間移植(PTCy-haplo)は、HLA半合致移植のプラットホームとなりつつある。しかしながら、近年の一連のメタ解析にはHLA適合移植と比較して、慢性GVHDのリスクは低いものの、HLA適合非血縁と比べると再発が多いとする報告がある。再発率の低減のためには、PTCy-haploによるgraft-versus-leukemia(GVL)効果の機序に関する分析が重要である。PTCy-haploにおいてはGVL効果には、NK細胞による同種反応が大きな役割を果たしていることを示唆するいくつかの報告がある。しかしながら、PTCyがNK細胞の回復に影響を与えるという報告もある。今後さらなる成績改善のために、ドナー選択方法、移植片の細胞輸注量、PTCyの至適用量やタイミング、および免疫抑制剤の投与方法など、さまざまな角度からの検討の必要があると考える。(著者抄録)

  • 【造血器腫瘍】造血幹細胞移植と細胞療法の展開 HLA不適合血縁者間移植 Reviewed

    中前 博久

    (有)科学評論社 腫瘍内科   26 ( 6 )   643 - 649   2020.12( ISSN:1881-6568

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  • 【慢性骨髄性白血病(CML)診療の最近の進歩】移行期/急性転化期CML治療の現状 Reviewed

    中前 博久

    (有)科学評論社 血液内科   78 ( 5 )   612 - 618   2019.05( ISSN:2185-582X

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  • Current status of HLA haplo-identical transplantation using post-transplantation cyclophosphamide(和訳中) Reviewed

    Nakamae Hirohisa

    (一社)日本造血細胞移植学会 日本造血細胞移植学会雑誌   8 ( 1 )   16 - 21   2019.01

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  • Comparable Survival Outcomes of Haploidentical Stem Cell Transplantation and Unrelated Bone Marrow Transplantation

    Junichi Sugita, Yoshiko Atsuta, Mio Kurata, Hirohisa Nakamae, Naoki Kurita, Ken Ishiyama, Souichi Shiratori, Takahiro Fukuda, Kazuteru Ohashi, Yukiyasu Ozawa, Junya Kanda, Tatsuo Ichinohe, Takanori Teshima

    BLOOD   132   2018.11( ISSN:0006-4971 ( eISSN:1528-0020

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    Publishing type:Research paper, summary (international conference)  

    0

    DOI: 10.1182/blood-2018-99-114770

  • 【白血病学(下)-最新の基礎、臨床研究-】 白血病の治療 総論 造血幹細胞移植(理論、方法) GVL(graft versus leukemia)効果のメカニズム Reviewed

    中前 博久

    (株)日本臨床社 日本臨床   74 ( 増刊10 白血病学(下) )   31 - 35   2016.12( ISSN:0047-1852

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  • PostCY大量療法を用いたハプロ移植 Reviewed

    中前 博久

    (有)科学評論社 血液内科   73 ( 5 )   697 - 702   2016.11( ISSN:2185-582X

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  • ステロイド抵抗性慢性移植片対宿主病患者におけるタミバロテンの非盲検多施設共同第II相試験(An Open-labeled, Multicenter Phase II Study of Tamibarotene in Patients with Steroid-refractory Chronic Graft-versus-Host Disease) Reviewed

    Maeda Yoshinobu, Nishimori Hisakazu, Inamoto Yoshihiro, Nakamae Hirohisa, Sawa Masashi, Mori Yasuo, Ohashi Kazuteru, Fujiwara Shin-ichiro, Tanimoto Mitsune

    岡山大学医学部 Acta Medica Okayama   70 ( 5 )   409 - 412   2016.10( ISSN:0386-300X

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  • 【同種造血幹細胞移植の多様性:細胞ソースと血縁・非血縁】 血縁者間HLAハプロ一致移植 移植後大量シクロホスファミドを用いた血縁者間HLAハプロ一致移植 Reviewed

    中前 博久

    (株)医薬ジャーナル社 血液フロンティア   26 ( 5 )   689 - 695   2016.04( ISSN:1344-6940

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    2008年の移植後大量シクロホスファミド(PT/Cy)を用いた血縁者間HLA半合致移植の報告以降、PT/Cy HLAハプロ一致移植は急速に世界的に広がりを見せている。また、最近の報告では、非血縁間移植との比較において、PT/Cy HLAハプロ一致移植は生存率を低下させることなく、慢性GVHDの発症率を有意に低下させることが示された。この利点から、PT/Cy HLAハプロ一致移植を良性の血液疾患に適応拡大する試みも行われており、将来、移植ソースの選択における、パラダイムシフトが起こる可能性を予感させる。(著者抄録)

  • 【免疫症候群(第2版)-その他の免疫疾患を含めて-】 続発性免疫不全症候群 各種疾患・病態にみられる免疫異常 造血器疾患にみられる免疫異常 慢性骨髄性白血病 Reviewed

    中前 博久

    (株)日本臨床社 日本臨床   別冊 ( 免疫症候群II )   743 - 746   2016.01( ISSN:0047-1852

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  • 造血幹細胞 移植後シクロホスファミド大量療法を用いたHLA半合致造血幹細胞移植 Reviewed

    中前 博久

    (株)中外医学社 Annual Review血液   2015   41 - 47   2015.01

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    近年,Luznik Lらにより,移植後の大量のシクロホスファミド(PT/Cy)を用いることで,選択的な同種反応性T細胞の除去により,GVHDおよび,拒絶の双方向の免疫寛容の誘導が可能となることが示された.続いて,シアトルとボルチモアのグループにより,PT/Cyの免疫寛容の誘導効果により,血縁HLA半合致造血細胞移植が比較的安全に行えることが報告された.この方法は,従来の生体内外でのT細胞除去による移植に比べて,複雑な操作を必要とせず,安価であるため,近年,世界的に広がりを見せている.また,移植前処置を強化することで,非寛解症例でも比較的良好な成績が得られることも示されてきている.さらに,後方視的な解析により,PT/Cyを用いた場合は,血縁HLA半合致ドナーが代替幹細胞源に,十分なりうることを示した複数の報告が発表され,この移植方法の今後の発展が期待されている.(著者抄録)

  • 移植後のシクロフォスファミド大量療法を用いたHLA半合致同種造血細胞移植法(ハプロ移植) Reviewed

    中前 博久, 日野 雅之

    「血液診療」編集委員会 血液診療   10 ( Suppl. )   37 - 38   2013.12

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  • 【慢性骨髄性白血病診療の現状と新たな展開2013】 CMLに対する予後予測スコア 日常診療における有用性 Reviewed

    中前 博久

    (有)科学評論社 血液内科   67 ( 2 )   138 - 143   2013.08( ISSN:2185-582X

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  • 真菌感染症情報 Risk factor and prophylaxis of invasive fungal disease on allo-SCT Reviewed

    神田 善伸, de la Camara Rafael, 森 毅彦, 中前 博久, 賀古 真一, 仲宗根 秀樹, 西本 光孝

    (株)メディカルレビュー社 深在性真菌症: SFI Forum   6 ( 2 )   63 - 71   2010.10( ISSN:1880-4810

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  • 【発熱性好中球減少症】 同種造血幹細胞移植における発熱性好中球減少症時の真菌感染対策 Reviewed

    中前 博久

    (株)医薬ジャーナル社 血液フロンティア   20 ( 8 )   1185 - 1195   2010.07( ISSN:1344-6940

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    深在性真菌症は確定診断が容易ではないため、ハイリスク患者への予防に加え、診断レベルに応じて経験的治療、先制攻撃的治療、推定治療が段階的に試みられているが、アゾール系薬剤の予防に加え新規抗真菌薬剤の使用拡大で、non-albicans Candida、接合菌類やフサリウムなどの、以前にはほとんど見られなかった菌種が同種造血幹細胞移植後の深在性真菌症で増加しており問題となっている。深在性真菌症の可能性の高い患者に絞って、早期に菌種特異的で効果的な治療が開始できるようになるためには、さらなるエビデンスの集積が必要である。(著者抄録)

  • L-Asparaginaseが一時的に有効であったNasal NK/T-Cell Lymphoma

    坂本 恵利奈, 山根 孝久, 中根 孝彦, 武岡 康信, 廣瀬 朝生, 萩原 潔通, 中前 博久, 太田 健介, 平山 道彦, 伊倉 義弘, 大澤 政彦, 澤田 達, 鬼頭 敏幸, 日野 雅之

    癌と化学療法   32 ( 12 )   1993 - 1996   2005.11( ISSN:0385-0684

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    症例は48歳,男性.持続する鼻炎症状および右顔面腫脹を主訴に市立堺病院を受診,鼻腔内生検にてnasal NK/T-cell lymphomaと診断され,加療目的にて当科に紹介入院.CHOP療法を行ったが病巣は拡大したため,顔面および頸部に放射線照射を開始するとともにDeVIC療法を併用したが効果は認められなかった.腫瘍パラフィン標本のasparagine synthetase免疫染色が弱陽性であったことより,L-asparaginase投与を2コース行ったところ,症状改善とおよび腫瘍の縮小を認めた.3コース目開始直前より再び発熱が出現.L-asparaginaseを投与したがLDH,AST,ALTの上昇を認め急激な呼吸,循環不全のため永眠された.剖検では,血球貪食症候群および原疾患の多臓器への浸潤を認めた.放射線療法および多剤抵抗性のnasal NK/T-cell lymphomaに対しL-asparaginaseが有効であったが,単剤投与による効果は持続しなかった.今後,asparagine synthetase低発現NK/T-cell lymphomaに対しては初回治療として積極的にL-asparaginaseを組み込んだ化学療法を考慮する必要がある(著者抄録)

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Presentations

  • Acquired angioedema as a late-onset complication after allogeneic stem cell transplantation Domestic conference

    2024.03 

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  • Effect of conditioning regimens and GVHD prophylaxis on UCBT performed with CY/TBI-based regimens Domestic conference

    2024.03 

  • Relationship between PTCy Dosage and Effects of HLA-B Leader in HLA-Haploidentical SCT Domestic conference

    2024.03 

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    Presentation type:Oral presentation (general)  

  • Letermovir prophylaxis for cytomegalovirus reactivation after allo-HCT Domestic conference

    2024.03 

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    Presentation type:Oral presentation (general)  

  • Comparison of CBT and unrelated BMT for CMML Domestic conference

    2024.03 

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  • Usefulness of web-based application for health status monitoring before and after PBSCH Domestic conference

    2024.03 

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  • HSCT from haploidentical offspring using PTCY versus matched sibling in older patients with MDS Domestic conference

    2024.03 

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    Presentation type:Oral presentation (general)  

  • Bleeding events with ibrutinib for cGVHD due to collagen-mediated platelet aggregation disorder Domestic conference

    2024.03 

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    Presentation type:Oral presentation (general)  

  • PBSCT using haploidentical donor with PTCy versus matched sibling donor for lymphoma Domestic conference

    2024.03 

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    Presentation type:Oral presentation (general)  

  • Aggressive NK-cell leukemiaの治療過程で眼窩腫瘤性病変を生じた症例 Domestic conference

    田上 瑞記, 坂井 淳, 春名 優甫, 三澤 宜彦, 冨田 真未, 中前 博久, 本田 茂

    眼科臨床紀要  2024.01  眼科臨床紀要会

  • Thrombotic and Bleeding Events in Japanese Adolescent and Young Adult PV and ET: Results from Japanese Multicenter Retrospective Study International conference

    65th ASH (American Society of Hematology)   2023.12 

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    Venue: San Diego, California, USA  

  • Interim Phase I Safety Study of Anti-Transferrin Receptor Antibody(PPMX-T003) in Patients with Polycythemia Vera International conference

    65th ASH (American Society of Hematology)   2023.12 

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    Venue: San Diego, California, USA  

  • Comparison of Non-Relapse Mortality after Haploidentical Hematopoietic Stem Cell Transplantation with Post-Transplant Cyclophosphamide Versus Single Umbilical Cord Blood Transplantation for Hematologic Disease International conference

    65th ASH (American Society of Hematology)   2023.12  San Diego, California, USA

  • CR1 Favors PTCy-haplo over UCB in Allogeneic Stem Cell Transplantation for Adult Patients with AL International conference

    65th ASH (American Society of Hematology)   2023.12 

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    Venue: San Diego, California, USA  

  • Effect of Early Cytomegalovirus Reactivation on Relapse in Adult Patients with Myelodysplastic Syndromes after Allogeneic Hematopoietic Stem Cell Transplantation: A Registry Study from the Japan Society for Transplantation and Cellular Therapy International conference

    65th ASH (American Society of Hematology)   2023.12 

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    Venue: San Diego, California, USA  

  • Impact of Letermovir Prophylaxis for Cytomegalovirus Reactivation on Post-Transplant Outcomes 100 Days before and after Allogeneic Hematopoietic Cell Transplantation International conference

    65th ASH (American Society of Hematology)   2023.12 

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    Presentation type:Poster presentation  

    Venue: San Diego, California, USA  

  • ダサチニブと強力化学療法で寛解を得たcryptic Philadelphia染色体を伴う骨髄異形成症候群 Domestic conference

    第119回近畿血液学地方会  2023.11 

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    Venue:千里ライフサイエンスセンター  

  • 高強度な初期治療により救命し得た進行性EBウイルス関連リンパ増殖性疾患 Domestic conference

    第119回 近畿血液学地方会  2023.11  日本血液学会

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    Venue:千里ライフサイエンスセンター  

  • 2度のICU管理を経てイサツキシマブ・デキサメサゾンで良好な病勢制御を得た多発性骨髄腫 Domestic conference

    第119回 近畿血液学地方会  2023.11  日本血液学会

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    Venue:千里ライフサイエンスセンター  

  • The Dose Impacts of Post-transplant Cyclophosphamide on Outcomes After HLA-haploidentical Allogeneic Hematopoietic Cell Transplantation International conference

    Asia Pacific Blood and Marrow Transplantation (APBMT)  2023.10  Asia Pacific Blood and Marrow Transplantation (APBMT)

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    Venue:Indonesia  

  • Clinical utility of isatuximab ± dexamethasone: Insights from a real-world multicenter study Invited Domestic conference

    2023.10 

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  • Direct antiglobulin test negative AIHA after PTCy based haploidentical PBSCT for MDS Domestic conference

    2023.10 

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  • Immunomodulatory and direct activities of ropeginterferon alfa-2b in mouse models of leukemia Domestic conference

    2023.10 

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  • Immunosuppression with steroids, cyclophosphamideand tacrolimus for pulmonary complication of MDS Domestic conference

    2023.10 

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  • CMV reactivation is associated with a reduced risk of relapse in acute leukemia after HCT Domestic conference

    2023.10 

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  • Prediction of emergency admissions with allo-HCT complications using an ePRO mobile app Domestic conference

    2023.10 

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  • HSCT for children and adolescents/young adults with de novo blast phase CML in the TKI era Domestic conference

    2023.10 

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  • Efficacy and safety of IsaPd for relapsed/refractory multiple myeloma: a retrospective study Domestic conference

    2023.10 

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  • A multi-institutional real-world outcome of IsaKd therapy for RRMM Domestic conference

    2023.10 

  • Effect of donor characteristics on haploidentical transplantation is modulated by GVHD prophylaxis Domestic conference

    2023.10 

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  • Impact of Bcl-2 high expressed T cells induced by venetoclax on graft-versus-leukemia effects Domestic conference

    2023.10 

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  • Antibody-mediated immunity to DBY/HLA class II complex formation in chronic GVHD and GVL effect Domestic conference

    2023.10 

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  • Effect of infused cell dose on second transplant with PTCy-haplo for R/R acute leukemia Domestic conference

    2023.10 

  • Haploidentical peripheral blood stem cell transplant vs matched unrelated donor transplant for MDS Domestic conference

    2023.10 

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  • Prognostic factors in haploidentical transplantation with post-transplant cyclophosphamide for AML Domestic conference

    2023.10 

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  • 脳出血により急激な転機を辿った二次性中枢神経リンパ腫の一例 Domestic conference

    第241回 日本内科学会近畿地方会  2023.09  日本内科学会近畿支部

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    Venue:梅田スカイビルタワーウエスト・web開催  

  • B細胞性急性リンパ性白血病の同種造血幹細胞移植後の髄外再発に対してBlinatumomabとドナーリンパ球輸注の併用療法で長期生存を獲得した1例 Domestic conference

    第241回 日本内科学会近畿地方会  2023.09  日本内科学会近畿支部

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    Venue:梅田スカイビルタワーウエスト・web開催  

  • 同種移植後に抗真菌薬不応性の播種性Candida guilliermondii感染を認め、Blastobotrys mokoenaiiのブレイクスルー感染を併存して致死的経過を辿った一例 Domestic conference

    第118回 近畿血液学地方会  2023.05  日本血液学会

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    Venue:大阪国際交流センター  

  • BRAFV600E変異が陰性であった古典的有毛細胞白血病の1例 Domestic conference

    第239回 日本内科学会近畿地方会  2023.03  日本内科学会近畿支部

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    Venue:大阪国際交流センター  

  • 胆管炎類似症状を来たし難渋したものの皮膚生検で診断がついた血管内リンパ腫の1例 Domestic conference

    第239回 日本内科学会近畿地方会  2023.03  日本内科学会近畿支部

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    Venue:大阪国際交流センター  

  • 頭蓋内混合性胚細胞腫瘍の治療中に急性骨髄性白血病と診断された1例 Domestic conference

    第239回 日本内科学会近畿地方会  2023.03  日本内科学会近畿支部

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    Venue:大阪国際交流センター  

  • Pathogenesis and Biomarkers for SOS Invited Domestic conference

    Hirohisa Nakamae

    2023.02 

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  • Association between candidemia and non-infectious interstitial pneumonia after allogeneic HCT Domestic conference

    2023.02 

  • Impact of early CMV reactivation on relapse in adult patients with MDS after allogeneic HSCT Domestic conference

    2023.02 

  • Fatal picornaviral pneumonia that was difficult to differentiate from IPS after DLI Domestic conference

    2023.02 

  • The usefulness of web application to record ePRO for outpatients after allo-HCT Domestic conference

    2023.02 

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  • Usefulness of autotaxin for predicting sinusoidal obstruction syndrome after allogenic HCT Domestic conference

    2023.02 

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  • Time-varying predictive power of WT1mRNA for post-SCT relapse in AML/MDS and dynamic prediction Domestic conference

    2023.02 

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  • Impact of transplantation procedure on long-term transplantation outcome of ATL Domestic conference

    2023.02 

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  • Time-Sequential Change of the Predictive Power of Peripheral Blood WT1mRNA Levels after Allogeneic Stem Cell Transplantation for Myeloid Neoplasm Relapse and Development of a Dynamic Relapse Prediction Model International conference

    64th ASH (American Society of Hematology)   2022.12 

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    Venue: New Orleans, LA. USA  

  • S. maltophilia-associated fulminant metastatic cellulitis and Candida fungemia in a CBT recipient Domestic conference

    2022.10 

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  • A case of catastrophic disseminated toxoplasmosis mimicking late-onset SOS after unrelated PBSCT Domestic conference

    2022.10 

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  • Posttransplantation cyclophosphamide leads to well-developed long-term memory B cell reconstitution Domestic conference

    2022.10 

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  • Primary tracheal adult T-cell leukemia/lymphoma resected using a rigid bronchoscope Domestic conference

    2022.10 

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  • CMV gastroenteritis after acute GVHD Domestic conference

    2022.10 

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  • Pretransplant hepatomegaly predicts relapse in patients with acute leukemia and MDS in non-remission Domestic conference

    2022.10 

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  • A non-infectious fever and pulmonary events before HCT are prognostic risk factors for MDS patients Domestic conference

    2022.10 

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  • Ibrutinib monotherapy in an elderly patient with Richter syndrome Domestic conference

    2022.10 

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  • Shunt index by per-rectal portal scintigraphy can predict SOS development Domestic conference

    2022.10 

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  • Prognostic impact of complex karyotype on post-transplant outcomes of myelofibrosis Domestic conference

    2022.10 

  • Prognostic impact of complex karyotype on post-transplant outcomes of myelofibrosis Domestic conference

    2022.10 

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  • Identifying the optimal conditioning intensity of HSCT in patients with MDS Domestic conference

    2022.10 

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  • Intensified intensity of conditioning regimens improved DFS and engraftment after single CBT Domestic conference

    2022.10 

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  • Isatuximab-based treatment outside the clinical trial in our multiple institutes Domestic conference

    2022.10 

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  • 末梢血リンパ球増多を呈したMYD88変異陽性非分泌型リンパ形質細胞性リンパ腫 Domestic conference

    第113回 近畿血液学地方会  2022.06  日本血液学会

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    Venue:Web開催  

  • 急性前骨髄球性白血病の寛解導入療法中に分化症候群の一つとして急性膵炎を発症した1例 Domestic conference

    枡谷彩耶,仲子聡一郎,幕内陽介,久野雅智,高桑輝人,西本光孝,中嶋康博,康 秀男,中前博久,日野雅之

    第234回内科学会近畿地方会  2021.12 

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  • A Prospective Comparison Analysis of Blood Biomarkers for the Diagnosis and Prediction of Sinusoidal Obstruction Syndrome International conference

    63th ASH (American Society of Hematology)   2021.12 

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    Venue:virtual  

  • The Outcomes of Systemic Chronic Active EBV Infection Treatment By Allogeneic Hematopoietic Stem Cell Transplantation: An Analysis of Japanese Registry Data International conference

    65th ASH (American Society of Hematology)   2021.12 

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    Venue:virtual  

  • Cytomegalovirus Gastroenteritis in Patients with Acute Graft-Versus-Host Disease International conference

    63th ASH (American Society of Hematology)   2021.12 

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  • Outcomes of Haploidentical Salvage Transplantation Using Post-Transplant Cyclophosphamide for Graft Failure Following Allogeneic Hematopoietic Stem Cell Transplantation International conference

    63th ASH (American Society of Hematology)   2021.12 

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  • 成熟B細胞性腫瘍の経過観察中にCOVID-19ワクチンを接種し、自己免疫性溶血性貧血を発症した症例

    曽我部信広、久野雅智、幕内陽介、高桑輝人、岡村浩史、西本光孝、中嶋康博、康 秀男、中前博久、日野雅之

    第116回近畿血液学地方会  2021.11 

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  • チロシンキナーゼ阻害剤治療注慢性骨髄性白血病の心血管有害事象に対する臨床検査パラメータによる予測 Domestic conference

    中前美佳、中前博久、橋本深香、廣瀬朝生、中嶋康博、久保田 浩、日野雅之

    第68回日本臨床検査医学会  2021.11 

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  • MGUSから多発性骨髄腫に進行し急速な多臓器不全を呈したアミロイドーシスの一例(A case of rapid multi-organ failure with amyloidosis that progressed from MGUS to multiple myeloma)

    田添 久実代, 高桑 輝人, 幕内 陽介, 久野 雅智, 岡村 浩史, 南野 智, 西本 光孝, 中嶋 康博, 康 秀男, 中前 博久, 日野 雅之

    日本血液学会学術集会  2021.09  (一社)日本血液学会

  • ペンブロリズマブ中止4ヶ月後に発症した遅発性免疫関連好中球減少症

    仲子聡一郎、中嶋康博、岡村浩史、幕内陽介、久野雅智、高桑輝人、西本光孝、康 秀男、中前博久、日野雅之

    第232回内科学会近畿地方会  2021.06 

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  • Pretransplant Plasma Brain Natriuretic Peptide and N-Terminal Pro-Brain Natriuretic Peptide Are More Useful Prognostic Markers of Overall Survival after Allogeneic Hematopoietic Cell Transplantation Than Echocardiography International conference

    62th ASH (American Society of Hematology)   2020.12 

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    Venue: San Diego, California, USA  

  • 血縁HLA半合致造血細胞移植後のGVHD/GVL効果の制御 Domestic conference

    中前 博久

    移植  2020.10  (一社)日本移植学会

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  • 同種造血細胞移植後早期の補体Ba上昇は移植関連血栓性微小血管症の発症予測マーカーになり得る Domestic conference

    岡村 浩史, 中前 博久, 進藤 岳郎, 大谷 克城, 日高 義彦, 大塚 泰史, 南野 智, 中嶋 康博, 康 秀男, 廣瀬 朝生, 中前 美佳, 日野 雅之, 若宮 伸隆, 井上 徳光

    移植  2020.10  (一社)日本移植学会

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  • 原発性皮膚CD8陽性急速進行性表皮向性細胞傷害性T細胞リンパ腫の1例 Domestic conference

    中井 久実代, 中根 孝彦, 田垣内 優美, 岡村 浩史, 南野 智, 中前 博久, 日野 雅之, 桑江 優子, 大澤 政彦

    臨床血液  2020.02  (一社)日本血液学会-東京事務局

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  • Impact of Donor KIR and HLA Genotypes on Clinical Outcomes According to Pre-Transplant Remission Status after HLA-Haploidentical Transplantation with Post-Transplantation Cyclophosphamide International conference

    Ido K, Koh H, Okamura H, Koh S, Nanno S, Nishimoto M, Hirose A, Nakamae M, Nakashima Y, Nakane T, Hino M, Nakamae H

    61th ASH (American Society of Hematology)   2019.12 

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  • Pretransplant Risk Factors for Calcineurin Inhibitor-Induced Encephalopathy and Limbic Encephalitis Following Allogeneic Hematopoietic Cell Transplantation International conference

    Tanizawa N, Koh H, Okamura H, Shiro K, Nanno S, Nishimoto M, Hirose A, Nakamae M, Nakashima Y, Nakane T, Hino M, Nakamae H

    61th ASH (American Society of Hematology)   2019.12 

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  • 非寛解期急性骨髄性白血病において同種造血細胞移植前末梢血WT1 mRNAレベルに比例して移植後の死亡リスクが増加する Domestic conference

    井戸 健太郎, 中前 美佳, 康 秀男, 岡村 浩史, 南野 智, 西本 光孝, 武岡 康信, 廣瀬 朝生, 中嶋 康博, 橋本 由徳, 中根 孝彦, 日野 雅之, 中前 博久

    大阪市医学会雑誌  2019.12  大阪市医学会

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  • 機械学習とR/shinyを用いた患者個別の予測生存曲線描出アプリケーションの開発 Domestic conference

    岡村 浩史, 中前 美佳, 橋本 匡生, 森口 慎, 谷澤 直, 木村 友美, 中井 久実代, 田垣内 優美, 林 哲哉, 酒徳 一希, 井戸 健太郎, 原田 尚憲, 康 史朗, 南野 智, 中嶋 康博, 康 秀男, 中根 孝彦, 廣瀬 朝生, 中前 博久, 島崎 伸裕, 平松 武士, 下岸 亮祥, 下野 直美, 竹本 恭彦, 日野 雅之

    医療情報学連合大会論文集  2019.11  (一社)日本医療情報学会

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  • 巨脾で発症したアグレッシブNK細胞白血病の1例 Domestic conference

    森口 慎, 中嶋 康博, 岡村 浩史, 南野 智, 康 秀男, 中根 孝彦, 中前 博久, 日野 雅之, 大澤 政彦

    臨床血液  2019.10  (一社)日本血液学会-東京事務局

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  • 気管食道瘻合併の未分化大細胞リンパ腫に対し、自家造血幹細胞移植後に外科的再建術を施行した1例 Domestic conference

    林 哲哉, 南野 智, 中嶋 康博, 中前 博久, 日野 雅之, 中 亮子, 藤原 有史, 形部 憲, 李 栄柱, 岡本 幸美

    臨床血液  2019.01  (一社)日本血液学会-東京事務局

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  • Noninvasive diagnostic approach by per rectal portal scintigraphy for sinusoidal obstruction syndrome after allogeneic hematopoietic cell transplantation International conference

    Okamura H, Koh H, Ido K, Makuuchi Y, Takakuwa T, Ine S, Nanno S, Nakashima Y, Nakane T, Jogo A, Yamamoto A, Hamuro M, Yoshida A, Kotani K, Higashiyama S, Kawabe J, Shiomi S, Ohsawa M, Hino M, Nakamae H

    60th ASH (American Society of Hematology)   2018.12 

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  • The Proportional Association between WT1 mRNA level in Peripheral Blood before Allogeneic Hematopoietic Cell Transplantation and Risk of Mortality in Acute Myeloid Leukemia Not in Remission International conference

    Ido K, Nakamae M, Koh H, Okamura H, Nanno S, Nishimoto M, Hashimoto Y, Takeoka Y, Hirose A, Nakashima Y, Nakane T, Hino M, Nakamae H

    60th ASH (American Society of Hematology)   2018.12 

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  • Pre-transplant Serum Beta-2 Microglobulin Level is**a Potential Novel Prognostic Marker for **Overall Survival after Allogeneic Hematopoietic Stem Cell Transplantation International conference

    Harada H, Nakane T, Nakamae M, Okamura H, Nanno S, Nishimoto M, Takeoka Y, Hirose A, Nakashima Y, Koh H, Hino M, Nakamae H

    60th ASH (American Society of Hematology)   2018.12 

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  • 経気管支肺胞生検による病理学的診断により治療し得た肺浸潤を伴う急性単球性白血病 Domestic conference

    原田 尚憲, 中根 孝彦, 岡村 浩史, 南野 智, 中嶋 康博, 康 秀男, 中前 博久, 日野 雅之

    臨床血液  2018.11  (一社)日本血液学会-東京事務局

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  • 自己免疫症状を呈する血液疾患におけるB細胞性免疫異常の検討 Domestic conference

    武田 真一, 中前 美佳, 廣瀬 朝生, 中根 孝彦, 中前 博久, 日野 雅之

    臨床病理  2018.10  日本臨床検査医学会

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  • 慢性骨髄性白血病患者の心血管系合併症に対するABI、CAVI、頸部エコー検査の意義に関する包括的検討 Domestic conference

    中前 美佳, 中前 博久, 橋本 深香, 吉川 淳一, 藤岡 一也, 日野 雅之

    臨床病理  2018.10  日本臨床検査医学会

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  • 非再発死亡から見た血縁者間性別不一致移植におけるドナーソース選択(Impact of PB vs BM on NRM and survival in female to male HCT from HLA-matched related donors) Domestic conference

    仲宗根 秀樹, 河村 浩二, 藥師神 公和, 篠原 明仁, 金森 平和, 大橋 一輝, 福田 隆浩, 内田 直之, 中前 博久, 諫田 淳也, 一戸 辰夫, 熱田 由子, 稲本 賢弘, 瀬尾 幸子, 木村 文彦, 緒方 正男

    臨床血液  2018.09  (一社)日本血液学会-東京事務局

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  • 精巣原発PTCL, NOSの1例(A rare case of peripheral T-cell lymphoma, not otherwise specified(PTCL-NOS) of testis) Domestic conference

    田垣内 優美, 中嶋 康博, 岡村 浩史, 南野 智, 康 秀男, 中根 孝彦, 中前 博久, 日野 雅之

    臨床血液  2018.09  (一社)日本血液学会-東京事務局

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  • 本態性血小板血症患者のリスク層別(Risk stratification in patients with essential thrombocythemia) Domestic conference

    橋本 由徳, 中前 博久, 田中 孝幸, 小村 裕美, 堀内 美令, 吉村 卓朗, 高桑 輝人, 麥谷 安津子, 廣瀬 朝生, 中前 美佳, 康 秀男, 日野 雅之

    臨床血液  2018.09  (一社)日本血液学会-東京事務局

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  • 急性骨髄性白血病に対する同種造血幹細胞移植成績の過去20年間の変遷(Trends in survival of AML patients undergoing related and unrelated HCT during the past two decades) Domestic conference

    柳田 正光, 増子 正義, 森 甚一, 青木 淳, 水野 昌平, 福田 隆浩, 垣花 和彦, 小澤 幸泰, 太田 秀一, 金森 平和, 森 毅彦, 中前 博久, 衛藤 徹也, 白鳥 聡一, 前田 哲生, 岩戸 康治, 一戸 辰夫, 神田 善伸, 田中 淳司, 熱田 由子, 矢野 真吾

    臨床血液  2018.09  (一社)日本血液学会-東京事務局

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  • 再生不良性貧血に対するフルダラビン、メルファラン、TBI 4Gy前処置による臍帯血移植(Fludarabine/Melphalan/4-Gy TBI followed by umbilical cord blood transplantation for aplastic anemia) Domestic conference

    康 秀男, 吉村 卓朗, 田垣内 優美, 林 哲哉, 原田 尚憲, 岡村 浩史, 南野 智, 廣瀬 朝生, 中前 美佳, 中嶋 康博, 中根 孝彦, 日野 雅之, 中前 博久

    臨床血液  2018.09  (一社)日本血液学会-東京事務局

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  • スキルス胃癌由来エキソソームが腹膜微小環境におよぼす影響 Domestic conference

    奥野 倫久, 八代 正和, 三木 友一朗, 黒田 顕慈, 栂野 真吾, 笠島 裕明, 中前 博久, 中根 孝彦, 日野 雅之, 平川 弘聖, 大平 雅一

    日本外科学会定期学術集会抄録集  2018.04  (一社)日本外科学会

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  • 血縁者間同種末梢血幹細胞移植におけるCD34陽性細胞数低値例の移植成績 Domestic conference

    山本 千裕, 小川 啓恭, 福田 隆浩, 五十嵐 愛子, 奥村 廣和, 内田 直之, 日高 道弘, 中前 博久, 松岡 賢市, 衛藤 徹也, 一戸 辰夫, 熱田 由子, 神田 善伸

    日本輸血細胞治療学会誌  2018.04  (一社)日本輸血・細胞治療学会

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  • スキルス胃癌由来エキソソームが腹膜中皮細胞におよぼす影響(Effect of exosomes from scirrhous gastric cancer cells on the peritoneal mesothelial cells) Domestic conference

    奥野 倫久, 八代 正和, 三木 友一朗, 栂野 真吾, 黒田 顕慈, 北山 紀州, 笠島 裕明, 中前 博久, 中根 孝彦, 日野 雅之, 平川 弘聖, 大平 雅一

    日本胃癌学会総会記事  2018.03  (一社)日本胃癌学会

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  • 腸間膜腫瘤で発症した限局期節外性NK/T細胞リンパ腫、鼻型(ENKL)の1例 Domestic conference

    川添 麻衣, 田垣内 優美, 南野 智, 西本 光孝, 武岡 康信, 中嶋 康博, 中根 孝彦, 康 秀男, 中前 博久, 日野 雅之

    臨床血液  2018.02  (一社)日本血液学会-東京事務局

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  • Pre-Transplant Transferrin Saturation Levels As a Predictive Marker for Invasive Fungal Disease Following Allogeneic Hematopoietic Stem Cell Transplantation International conference

    Nanno S, Koh H, Nishimoto M, Nakane T, Nakashima Y, Takeoka Y, Nakamae M, Hirose A, Hino M, Nakamae H

    59th ASH (American Society of Hematology)   2017.12 

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  • Post-Transplant Cyclophosphamide Contributes to Impaired Graft-Versus-Leukemia Effects and Regulates Graft-Versus-Host Disease in the Murine Stem Cell Transplant Model International conference

    Makuuchi Y, Nakashima Y, Koh H, Nakane T, Nakamae H, Hino M

    59th ASH (American Society of Hematology)   2017.12 

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  • 移植前サイトメガロウイルスIgG陰性を呈したサイトメガロウイルス潜伏感染レシピエント Domestic conference

    井戸 健太郎, 康 史朗, 市原 弘善, 青山 泰孝, 麥谷 安津子, 中前 博久, 日野 雅之, 谷 慶彦

    臨床血液  2017.11  (一社)日本血液学会-東京事務局

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  • スキルス胃癌細胞由来エキソソームが腹膜組織におよぼす影響 Domestic conference

    奥野 倫久, 八代 正和, 三木 友一朗, 北山 紀州, 笠島 裕明, 中前 博久, 中根 孝彦, 日野 雅之, 平川 弘聖, 大平 雅一

    日本癌治療学会学術集会抄録集  2017.10  (一社)日本癌治療学会

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  • Ph+白血病の日本人患者におけるponatinibの第1/2相試験 3年間の経過観察の結果(Phase 1/2 study of Ponatinib in Japanese patients(Pts) with Ph+leukemia: 3-year follow-up results) Domestic conference

    Kyo Kohei, Tojo Arinobu, Kyo Taiichi, Yamamoto Kazuhito, Nakamae Hirohisa, Takahashi Naoto, Kobayashi Yukio, Tauchi Tetsuzo, Okamoto Shinichiro, Miyamura Koichi, Hatake Kiyohiko, Iwasaki Hiromi, Matsumura Itaru, Usui Noriko, Naoe Tomoki, Farin Heinrich, Ohyashiki Kazuma

    臨床血液  2017.09  (一社)日本血液学会-東京事務局

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  • 若年急性骨髄性白血病患者における移植前処置強度と同種移植成績との関連(Reduced-intensity conditioning allogeneic HCT for younger patients with acute myeloid leukemia) Domestic conference

    Yanada Masamitsu, Kurosawa Saiko, Kobayashi Takeshi, Ozawa Yukiyasu, Kanamori Heiwa, Kobayashi Naoki, Sawa Masashi, Nakamae Hirohisa, Uchida Naoyuki, Hashimoto Hisako, Fukuda Takahiro, Hirokawa Makoto, Atsuta Yoshiko, Yano Shingo

    臨床血液  2017.09  (一社)日本血液学会-東京事務局

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  • 真性多血症および本態性血小板血症におけるサイトカインプロファイルの分析(Different cytokine profiles in patients with polycythemia vera and essential thrombocythemia) Domestic conference

    Takakuwa Teruhito, Nakamae Mika, Nanno Satoru, Nishimoto Mitsutaka, Nakashima Yasuhiro, Koh Hideo, Nakane Takahiko, Takeoka Yasunobu, Hino Masayuki, Nakamae Hirohisa

    臨床血液  2017.09  (一社)日本血液学会-東京事務局

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  • 発作性夜間血色素尿症患者における活性酸素と血栓症(Oxidative stress and thrombotic complication in patients with paroxysmal nocturnal hemoglobinuria) Domestic conference

    Koh Shiro, Koh Hideo, Tsuchiya Masahiko, Katayama Takako, Nishimoto Mitsutaka, Nakane Takahiko, Hirose Asao, Nakamae Mika, Aoyama Yasutaka, Hirai Manabu, Mugitani Atsuko, Nakamae Hirohisa, Hino Masayuki

    臨床血液  2017.09  (一社)日本血液学会-東京事務局

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  • 日本人DLBCL患者におけるオビヌツズマブの有効性及び安全性 GOYA試験部分集団解析(Efficacy and safety of obinutuzumab in Japanese patients with DLBCL: A subgroup analysis of GOYA) Domestic conference

    Rai Shinya, Nakamae Hirohisa, Uchida Toshiki, Teshima Takanori, Nakaseko Chiaki, Izutsu Koji, Hatake Kiyohiko, Kitano Toshiyuki, Akashi Koichi, Tsurumi Hisashi, Kanakura Yuzuru, Nakajima Hideaki, Ueda Yasunori, Nagafuji Koji, Ohmine Ken, Tobinai Kensei, Suzumiya Junji, Ishida Yoji, Chou Takaaki, Tamura Hideto, Ishikawa Takayuki, Ueda Eisuke, Kuriki Hiroshi, Tatsumi Yoichi

    臨床血液  2017.09  (一社)日本血液学会-東京事務局

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  • クラドリビンが奏功したHairy Cell Leukemia-Japanese variantの一例(Successful cladribine treatment in a patient with hairy cell leukemia-Japanese variant) Domestic conference

    Nakane Takahiko, Okamura Hiroshi, Sakaida Noriko, Fujii Kazuki, Nakashima Yasuhiro, Koh Hideo, Nakamae Hirohisa, Ohsawa Masahiko, Hino Masayuki

    臨床血液  2017.09  (一社)日本血液学会-東京事務局

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  • Cidofovir treatment for adenovirus-associated hemorrhagic cystitis in adult recipients of allogeneic hematopoietic stem cell transplantation: a retrospective comparative study International conference

    Yoshimura T, Nishimono M, Nakane T, Koh H, Nakashima Y, Takeoka Y, Nakamae M, Hirose A, Hino M, Nakamae H

    BMT tandem meeting 2017  2017.02 

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  • AIHと非感染性肺炎を伴うMDSに同種造血幹細胞移植を施行した1例 Domestic conference

    浦上 実季, 岡村 浩史, 西本 光孝, 南野 智, 武岡 康信, 中嶋 康博, 康 秀男, 中根 孝彦, 中前 博久, 日野 雅之

    臨床血液  2017.01  (一社)日本血液学会-東京事務局

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  • Combination of Frailty Status and Comorbidity Score Improves the Prediction of Survival in Patients with Myelodysplastic Syndrome Due to Good Predictive Capability for Infection-Related Mortality International conference

    Sakatoku K, Takeoka Y, Araki T, Yamamura R, Nakane T, Nakamae H, Hino M, Ohta K

    58th ASH (American Society of Hematology)   2016.12 

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  • Discontinuation of Nilotinib in Patients with Chronic Myeloid Leukemia Who Have Maintained Deep Molecular Responses for at Least 2 Years: A Multicenter Phase 2 Stop Nilotinib (Nilst) Trial International conference

    Kadowaki N, Kawaguchi T, Kuroda J, Nakamae H, Matsumura I, Miyamoto T, Ishikawa J, Nagafuji K, Imamura Y, Yamazaki H, Shimokawa M, Akashi K, Kanakura Y

    58th ASH (American Society of Hematology)   2016.12 

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  • 心臓ペースメーカーを留置し化学療法を施行した心臓原発DLBCLの1例 Domestic conference

    幕内 陽介, 西本 光孝, 久野 雅智, 林 良樹, 中前 博久, 日野 雅之, 武坂 絢, 石井 英

    臨床血液  2016.11  (一社)日本血液学会-東京事務局

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  • 重度不整脈を伴うCML2症例の治療に対するdasatinib増量(Dose escalation of dasatinib for the treatment of two cases of CML with severe arrhythmia) Domestic conference

    Makuuchi Yosuke, Nishimoto Mitsutaka, Kuno Masatomo, Nagasaki Joji, Hayashi Yoshiki, Nakashima Yasuhiro, Koh Hideo, Nakane Takahiko, Nakamae Hirohisa, Hino Masayuki

    臨床血液  2016.09  (一社)日本血液学会-東京事務局

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  • 血球貪食症候群の診断におけるpresepsinと他のバイオマーカーの比較(Comparison between presepsin and other biomarkers for diagnosing hemophagocytic syndrome) Domestic conference

    Koh Hideo, Nanno Satoru, Katayama Takako, Hirose Asao, Nakamae Mika, Hino Masayuki, Nakamae Hirohisa

    臨床血液  2016.09  (一社)日本血液学会-東京事務局

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  • 自己免疫症状を呈する血液疾患におけるB細胞性免疫異常の検証のための基礎的検討 Domestic conference

    武田 真一, 中前 美佳, 中前 博久, 日野 雅之

    日本医学検査学会抄録集  2016.09  (一社)日本臨床衛生検査技師会

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  • 症例報告 大腸癌を合併した腫瘍随伴性免疫性血小板減少性紫斑病(Case report: Paraneoplastic immune thrombocytopenic purpura concurrent with colon cancer) Domestic conference

    Koh Shiro, Nakane Takahiko, Koga Yuki, Nishimoto Mitsutaka, Hayashi Yoshiki, Tauchi Yukie, Nagahara Hisashi, Koh Hideo, Nakashima Yasuhiro, Nakamae Hirohisa, Hirakawa Kosei, Hino Masayuki

    臨床血液  2016.09  (一社)日本血液学会-東京事務局

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  • 成人T細胞白血病/リンパ腫に対する臍帯血移植の実現可能性試験(A feasibility study of cord blood cell transplantation for adult T cell leukemia/lymphoma) Domestic conference

    Choi Ilseung, Miyazaki Yasuhiko, Moriuchi Yukiyoshi, Nagafuji Koji, Hidaka Michihiro, Nakamae Hirohisa, Kato Koji, Eto Tetsuya, Shigematsu Akio, Shimokawa Mototsugu, Watanabe Nobukazu, Fukushima Takuya, Wake Atsushi, Takatsuka Yoshifusa, Uchida Naoyuki, Taniguchi Shuichi, Utsunomiya Atae, Suehiro Youko, Fukuda Takahiro, Okamura Jun, Uike Naokuni

    臨床血液  2016.09  (一社)日本血液学会-東京事務局

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  • ステロイド抵抗性急性GVHDに対するセカンドライン治療としての低用量thymoglobulin JSHCT分析(Low-dose thymoglobulin as second-line treatment for steroid-resistant acute GVHD: a JSHCT analysis) Domestic conference

    Murata Makoto, Ikegame Kazuhiro, Morishita Yoshihisa, Ogawa Hiroyasu, Nakamae Hirohisa, Ikeda Takashi, Nishida Tetsuya, Inoue Masami, Eto Tetsuya, Ichinohe Tatsuo, Atsuta Yoshiko, Teshima Takanori

    臨床血液  2016.09  (一社)日本血液学会-東京事務局

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  • Ph+白血病の日本人患者におけるponatinibの第I/II相試験(Ponatinib phase 1/2 study in Japanese patients(pts) with Ph+ leukemia) Domestic conference

    Tojo Arinobu, Kyo Taiichi, Yamamoto Kazuhito, Takahashi Naoto, Nakamae Hirohisa, Kobayashi Yukio, Tauchi Tetsuzo, Okamoto Shinichiro, Miyamura Koichi, Iwasaki Hiromi, Hatake Kiyohiko, Matsumura Itaru, Usui Noriko, Yanase Kumiko, Hu Simin, Farin Heinrich, Naoe Tomoki, Ohyashiki Kazuma

    臨床血液  2016.09  (一社)日本血液学会-東京事務局

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  • CML患者におけるdasatinibとimatinibの比較 DASISIONの5年間追跡調査における日本人のサブ解析(Dasatinib versus imatinib in patients with CML: Japanese subanalysis of DASISION 5-year follow-up) Domestic conference

    Onishi Yasushi, Fujisawa Shin, Nakamae Hirohisa, Ogura Michinori, Uchida Toshiki, Taniwaki Masafumi, Utsunomiya Atae, Matsue Kosei, Takamatsu Yasushi, Usuki Kensuke, Tanimoto Mitsune, Ishida Yoji, Ohashi Kazuteru, Li Li, Miyoshi Masafumi

    臨床血液  2016.09  (一社)日本血液学会-東京事務局

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  • CD6を用いたTreg解析パネルの有用性について Domestic conference

    藤原 牧子, 藤井 一貴, 池本 彩, 今井 重良, 髭野 泰博, 中前 美佳, 中前 博久, 日野 雅之

    日本医学検査学会抄録集  2016.09  (一社)日本臨床衛生検査技師会

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  • 細胞透過剤PerFix-nc処理による細胞表面抗原への影響 Domestic conference

    藤井 一貴, 藤原 牧子, 池本 彩, 今井 重良, 久保田 浩, 髭野 泰博, 中前 美佳, 中前 博久, 日野 雅之

    日本検査血液学会雑誌  2016.07  (一社)日本検査血液学会

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  • 皮下脂肪量の低値は、新規発症の多発性骨髄腫において予後不良因子となる Domestic conference

    武岡 康信, 酒徳 一希, 三浦 晃子, 山村 亮介, 荒木 拓, 瀬浦 宏崇, 岡村 光英, 康 秀男, 中前 博久, 日野 雅之, 太田 健介

    International Journal of Myeloma  2016.04  日本骨髄腫学会

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  • 胃癌微小環境の骨髄由来細胞は癌の進展に関与する Domestic conference

    笠島 裕明, 八代 正和, 中前 博久, 三木 友一朗, 北山 紀州, 増田 剛, 櫻井 克宣, 豊川 貴弘, 久保 尚士, 田中 浩明, 六車 一哉, 大平 雅一, 中根 孝彦, 日野 雅之, 平川 弘聖

    日本胃癌学会総会記事  2016.03  (一社)日本胃癌学会

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  • Potential Value of Low-Dose ATG Treatment for Steroid-Resistant Acute GVHD International conference

    Murata M, Ikegame K, Ogawa H, Nakamae H, Ikeda T, Nishida T, Inoue M, Eto T, Ichinohe T, Atsuta Y, Teshima T, Morishita Y

    BMT tandem meeting 2016  2016.02 

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  • DLBCL長期寛解後に発症したBCL2、BCL6、MYC転座陽性のIntermediate BL/DLBCL Domestic conference

    駒倉 啓大, 高桑 輝人, 西本 光孝, 岡村 浩史, 林 良樹, 中嶋 康博, 康 秀男, 中根 孝彦, 中前 博久, 日野 雅之, 桑江 優子, 大澤 政彦

    臨床血液  2016.02  (一社)日本血液学会-東京事務局

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  • Pre-Transplant Autonomic Nervous System Malfunction Is a Powerful Predictor for Survival after Allogeneic Hematopoietic Cell Transplantation International conference

    Nakane T, NakamaeM, Koh H, Nishimoto M, Hayashi Y, Hirose A, Nakashima Y, Hino M, Nakamae H

    57th ASH (American Society of Hematology)   2015.12 

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  • 胃癌微小環境の骨髄由来細胞は癌の進展に関与する Domestic conference

    笠島 裕明, 八代 正和, 中前 博久, 三木 友一朗, 北山 紀州, 増田 剛, 櫻井 克宜, 豊川 貴弘, 久保 尚士, 田中 浩明, 六車 一哉, 大平 雅一, 中根 孝彦, 日野 雅之, 平川 弘聖

    日本分子腫瘍マーカー研究会誌  2015.12  日本分子腫瘍マーカー研究会

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  • B細胞性マーカー陽性を示した孤立性顆粒球肉腫 Domestic conference

    江崎 麻衣子, 高桑 輝人, 西本 光孝, 中根 孝彦, 岡村 浩史, 林 良樹, 中嶋 康博, 康 秀男, 中前 博久, 桑江 優子, 大澤 政彦, 日野 雅之

    臨床血液  2015.11  (一社)日本血液学会-東京事務局

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  • 発熱性好中球減少症の感染検出におけるバイオマーカーとしてのpresepsinとprocalcitoninの比較(Comparison of presepsin and procalcitonin as biomarkers to detect infection in febrile neutropenia) Domestic conference

    Koh Hideo, Aimoto Mizuki, Katayama Takako, Hirose Asao, Nakamae Mika, Hino Masayuki, Nakamae Hirohisa

    臨床血液  2015.09  (一社)日本血液学会-東京事務局

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  • 造血幹細胞移植におけるドナーの選択 ハプロと臍帯血の比較 移植後cyclophosphamide(PT/Cy)を減量用量で投与するHLAハプロタイプ一致同種造血細胞移植(Donor selection in hematopoietic stem cell transplantation: haplo versus cord blood HLA haplo-identical allogeneic hematopoietic cell transplantation using reduced dose post-transplantation cyclophosphamide(PT/Cy)) Domestic conference

    Nakamae Hirohisa

    臨床血液  2015.09  (一社)日本血液学会-東京事務局

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  • 胃癌微小環境の骨髄由来細胞は癌の進展に関与する Domestic conference

    笠島 裕明, 八代 正和, 中前 博久, 三木 友一朗, 北山 紀州, 増田 剛, 櫻井 克宜, 豊川 貴弘, 久保 尚士, 田中 浩明, 六車 一哉, 大平 雅一, 中根 孝彦, 日野 雅之, 平川 弘聖

    日本分子腫瘍マーカー研究会プログラム・講演抄録  2015.09  日本分子腫瘍マーカー研究会

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  • 胃 胃がんのゲノム解析 胃癌の進展に及ぼす骨髄由来間質細胞の関与の検討 Domestic conference

    笠島 裕明, 八代 正和, 中前 博久, 北山 紀州, 増田 剛, 木下 春人, 櫻井 克宣, 豊川 貴弘, 久保 尚士, 田中 浩明, 六車 一哉, 大平 雅一, 中根 孝彦, 日野 雅之, 平川 弘聖

    日本癌治療学会誌  2015.09  (一社)日本癌治療学会

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  • Ph+白血病の日本人患者におけるponatinibの安全性と有効性に関する第I/II相試験(Phase 1/2 study of ponatinib safety and efficacy in Japanese patients(pts) with Ph+ leukemia) Domestic conference

    Yamamoto Kazuhito, Tojo Arinobu, Kyo Taiichi, Takahashi Naoto, Nakamae Hirohisa, Kobayashi Yukio, Tauchi Tetsuzo, Okamoto Shinichiro, Miyamura Koichi, Iwasaki Hiromi, Hatake Kiyohiko, Matsumura Itaru, Usui Noriko, Yanase Kumiko, Hu Simin, Conlan Maureen, Naoe Tomoki, Ohyashiki Kazuma

    臨床血液  2015.09  (一社)日本血液学会-東京事務局

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  • NILSw試験の中間解析 IMでMMRがみられたCML-CP患者におけるNILの安全性と有効性(Interim analysis of NILSw trial: the safety and efficacy of NIL in pts with CML-CP showing MMR to IM) Domestic conference

    Kamimura Tomohiko, Kawaguchi Tatsuya, Kuroda Junya, Nakamae Hirohisa, Matsumura Itaru, Miyamoto Toshihiro, Ishikawa Jun, Fukushima Kentaro, Eto Tetsuya, Akashi Koichi, Kanakura Yuzuru

    臨床血液  2015.09  (一社)日本血液学会-東京事務局

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  • B細胞マーカーの発現を認めた非白血病性骨髄肉腫の稀な1症例(A rare case of nonleukemic myeloid sarcoma with expression of B-cell markers) Domestic conference

    Takakuwa Teruhito, Nakane Takahiko, Kuwae Yuko, Nishimoto Mitsutaka, Hayashi Yoshiki, Nakashima Yasuhiro, Koh Hideo, Nakamae Hirohisa, Ohsawa Masahiko, Hino Masayuki

    臨床血液  2015.09  (一社)日本血液学会-東京事務局

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  • Plasma levels of presepsin (soluble CD14-subtype) as a novel prognostic marker for hemophagocytic syndrome International conference

    Nanno S, Koh H, Katayama T, Hashiba M, Sato A, Makuuchi Y, Nagasaki J, Yoshimura T, Okamura H, Nishimoto M, Hirose A, Nakamae M, Nakane T, Hino M, Nakamae H

    20th Congress of EHA (European Hematology Association)   2015.06 

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  • Diagnostic value of plasma levels of presepsin (soluble CD14-subtype) for febrile neutropenia in patients with hematologic malignancies International conference

    Koh H, Katayama T, Hashiba M, Sato A, Kuno M, Makuuchi Y, Takakuwa T, Okamura H, Hirose A, Nakamae M, Hino M, Nakamae H

    20th Congress of EHA (European Hematology Association)   2015.06 

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  • 初発の非胚中心B細胞様びまん性大細胞型B細胞性リンパ腫患者を対象としたブルトン型チロシンキナーゼ(BTK)阻害薬PCI-32765(ibrutinib)の国際共同第III相試験 Domestic conference

    頼 晋也, 豊嶋 崇徳, 福原 規子, 飛内 賢正, 畠 清彦, 下山 達, 安藤 潔, 内田 俊樹, 永井 宏和, 谷脇 雅史, 柴山 浩彦, 中前 博久, 松村 到, 石川 隆之, 一戸 辰夫, 加藤 光次, 日高 道弘

    日本リンパ網内系学会会誌  2015.06  (一社)日本リンパ網内系学会

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  • Drug interaction and safety profiles of concomitant use of caspofungin and tacrolimus in allogeneic hematopoietic stem cell transplant recipients. International conference

    Nishimoto M, Koh H, Tokuwame A, Makuuchi Y, Kuno M, Takakuwa T, Okamura H, Koh S, Yoshimura T, Nanno S, Hayashi Y, Nakamae M, Hirose A, Nakashima Y, Nakane T, Hino M, Nakamae H

    41th EBMT (European Society for Blood and Marrow Transplantation)  2015.03 

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  • HLA半合致移植後再発時に肝胆道系酵素上昇を呈し、デフェラシロクスがDLSTで陽性となった症例 Domestic conference

    吉村 卓朗, 中前 博久, 岡村 浩史, 康 史朗, 西本 光孝, 康 秀男, 高田 さゆり, 萩原 淳司, 日野 雅之

    臨床血液  2015.01  (一社)日本血液学会-東京事務局

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  • Effectiveness of Antibacterial Prophylaxis with Non-Absorbable Polymyxin B Compared to Levofloxacin after Allogeneic Hematopoietic Stem Cell Transplantation International conference

    Koh S, Nakamae H, Yamada K, Nishimoto M, Hayashi Y, Koh H, Nakashima Y, Nakane T, Hirose A, Nakamae M, Kakeya H, Hino M

    56th American Society of Hematology  2014.12 

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  • Efficacy and Safety of Nilotinib (NIL) vs Imatinib (IM) in Patients (pts) With Newly Diagnosed Chronic Myeloid Leukemia in Chronic Phase (CML-CP): Long-Term Follow-Up (f/u) of ENESTnd International conference

    Larson AR, Kim D-W, Issaragrilsil S, le Coutre P, Llacer PDE, Etienne G, Clark ER, Flinn I, Nakamae H, Hochhaus A, Saglio G, Kantarjian MH, Donohue B, Deng W, Menssen DH, Hughes PT

    56th American Society of Hematology  2014.12 

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  • Allogeneic Peripheral Blood Stem Cell Transplantation Using Reduced-Intensity Conditioning Regimen with Fludarabine and Busulfan from HLA-Matched Related Donor for Elderly Adult T-Cell Leukemia/Lymphoma: Results of Multicenter Phase II Study (ATL-NST-3) International conference

    Tanosaki R, Choi I, Shimokawa M, Utsunomiya A, Tokunaga M, Nakano N, Fukuda T, Nakamae H, Takemoto S, Kusumoto S, Tomoyose T, Sueoka E, Shiratsuchi M, Suehiro Y, Yamanaka T, Okamura J, Uike N

    56th American Society of Hematology  2014.12 

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  • Azacitidine (AZA) Combination Therapy with Low-Dose AraC Is Well Tolerated and Highly Effective for MDS with Overt Leukemia International conference

    Hirai M, Aimoto M, Inoue A, Hashimura M, Sakamoto E, Nakamae H, Hino M

    56th American Society of Hematology  2014.12 

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  • A Detailed Analysis of Myelodysplastic Syndrome Complicated By Autoimmune or Inflammatory Disorders: A Possible Efficacy of Low-Dose Lenalidomide International conference

    Takeoka Y, Miura A, Nakamura K, Nakamura J, Yamamura R, Araki T, Nakamae H, Hino M, Ohta K

    56th American Society of Hematology   2014.12 

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  • The V50/V25 Ratio, a Marker of Small Airway Disease, Is Highly Predictive of Survival after Allogeneic Hematopoietic Cell Transplantation International conference

    Nakamae M, Nakamae H, Yamashita M, Nishimoto M, Hayashi Y, Koh H, Nakane T, Nakashima Y, Hirose A, Hino M

    56th American Society of Hematology  2014.12 

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  • トリソミー8を伴うMDS(RCMD)に合併した好酸球性視神経炎 Domestic conference

    長崎 譲慈, 西本 光孝, 中根 孝彦, 康 秀男, 幕内 陽介, 康 史朗, 中前 博久, 日野 雅之

    臨床血液  2014.11  (一社)日本血液学会-東京事務局

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  • Multi-color flow cytometryを用いた健常人の末梢血免疫担当細胞比率 Domestic conference

    藤井 一貴, 藤原 牧子, 山下 亘, 久保田 浩, 髭野 泰博, 中前 美佳, 中前 博久, 日野 雅之

    臨床病理  2014.10  日本臨床検査医学会

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  • 造血幹細胞移植患者における呼吸機能の推移や予後との関連 Domestic conference

    山下 真理子, 木村 信勲, 中前 美佳, 中前 博久, 髭野 泰博, 日野 雅之

    臨床病理  2014.10  日本臨床検査医学会

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  • 腸管の重度の移植片対宿主病に対するsteroid動脈内注入の有望なアウトカム(Promising outcomes from intra-arterial steroid infusions for severe gut graft-versus-host disease) Domestic conference

    Nishimoto Mitsutaka, Koh Hideo, Nakamae Hirohisa, Hirose Asao, Nakamae Mika, Nakane Takahiko, Hayashi Yoshiki, Okamura Hiroshi, Yoshimura Takurou, Koh Shirou, Nanno Satoru, Nakashima Yasuhiro, Toru Takeshit, Yamamoto Akira, Sakai Yukimasa, Nishida Norifumi, Matsuoka Toshiyuki, Miki Yukio, Hino Masayuki

    臨床血液  2014.09  (一社)日本血液学会-東京事務局

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  • 胃癌微小環境が及ぼす骨髄由来間質系幹細胞の誘導に関する検討(Bone Marrow Derived Mesenchymal Stem Cells Are Attracted into the Gastric Cancer Microenvironment) Domestic conference

    笠島 裕明, 八代 正和, 増田 剛, 木下 春人, 森崎 珠実, 福岡 達成, 中根 孝彦, 中前 博久, 日野 雅之, 大平 雅一, 平川 弘聖

    日本癌学会総会記事  2014.09  日本癌学会

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  • 経直腸門脈シンチグラフィーの同種HSCTにおける肝機能障害の原因診断における有用性(Usefulness of per rectal portal scintigraphy to diagnose the cause of liver dysfunction in allo-HSCT) Domestic conference

    Okamura Hiroshi, Koh Hideo, Takakuwa Teruhito, Nanno Satoru, Nishimoto Mitsutaka, Hayashi Yoshiki, Nakashima Yasuhiro, Nakane Takahiko, Hirose Asao, Nakamae Mika, Nakamae Hirohisa, Hino Masayuki, Osawa Masahiko, Yamamoto Akira, Kotani Kohei, Higashiyama Shigeaki, Kawabe Joji, Shiomi Susumu

    臨床血液  2014.09  (一社)日本血液学会-東京事務局

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  • 抗好中球抗体陽性無顆粒球症の成人症例(Adult case of anti-neutrophil antibody-positive agranulocytosis) Domestic conference

    Koh Shiro, Koh Hideo, Kuroda Maiko, Kubo Yuki, Inaba Mayumi, Kuno Masatomo, Makuuchi Yosuke, Okamura Hiroshi, Yoshimura Takuro, Nanno Satoru, Nishimoto Mitsutaka, Nakashima Yasuhiro, Nakamae Hirohisa, Ueda Makiko, Hino Masayuki

    臨床血液  2014.09  (一社)日本血液学会-東京事務局

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  • フィラデルフィア陽性白血病を有する日本人患者におけるponatinibの第I/II相試験に関する最新情報(Update of a phase 1/2 study of ponatinib in Japanese patients with Philadelphia positive leukemias) Domestic conference

    Tojo Arinobu, Kyo Taiichi, Yamamoto Kazuhito, Takahashi Naoto, Nakamae Hirohisa, Kobayashi Yukio, Tauchi Tetsuzo, Okamoto Shinichiro, Miyamura Koichi, Iwasaki Hiromi, Hatake Kiyohiko, Matsumura Itaru, Usui Noriko, Yanase Kumiko, Hu Simin, Turner Christopher, Naoe Tomoki, Ohyashiki Kazuma

    臨床血液  2014.09  (一社)日本血液学会-東京事務局

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  • 10カラーフローサイトメトリーによる正常骨髄細胞の表面抗原解析 Domestic conference

    藤原 牧子, 藤井 一貴, 池本 彩, 山下 亘, 久保田 浩, 髭野 泰博, 中前 美佳, 中前 博久, 日野 雅之

    Cytometry Research  2014.06  (一社)日本サイトメトリー学会

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  • 注射用ブスルファン投与時の痙攣発作予防に対するバルプロ酸ナトリウムの有効性および安全性に関する検討 Domestic conference

    徳和目 篤史, 高橋 正也, 光川 康子, 康 秀男, 中前 博久, 西川 武司, 日野 雅之, 永山 勝也

    日本薬学会年会要旨集  2014.03  (公社)日本薬学会

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  • Voriconazole vs. itraconazole for antifungal prophylaxis in patients with GVHD:A prospective randomized trial International conference

    Hayashi Y, Kanda Y, Nakamae H, Kanamori H, Ohashi K, Hidaka M, Yano S, Hatanaka K, Kono A, Moriuchi Y, Ago H, Yamashita T, Takata T, Yoshida M, Hino M, Yamaguchi T, Fukuda T

    2014 BMT tandem meeting   2014.02 

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  • 臍帯血移植後Coprinopsis Cinerea(Hormgraphiella Aspergillata)による播種性感染症を発症した1例 Domestic conference

    南野 智, 中根 孝彦, 岡村 浩史, 西本 光孝, 康 秀男, 中前 博久, 日野 雅之, 大澤 政彦, 村長 保憲, 亀井 克彦

    臨床血液  2014.02  (一社)日本血液学会-東京事務局

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  • HLA Haplo-Identical Peripheral Blood Stem Cell Transplantation Using High-Dose Cyclophosphamide Post-Transplantation For Poor Prognosis Or Refractory Acute Leukemia and Myelodysplastic Syndrome: A Prospective Pilot Study At a Single Center International conference

    Nakamae H, Koh H, Nishimoto M, Nakashima Y, Nanno S, Yoshimura T, Koh S, Okamura H, Nagasaki J, Nakane T, Nakamae M, Hirose A, Hino M

    55th American Society of Hematology  2013.12 

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  • Discontinuation Of Dasatinib In Patients With CML Who Have Maintained Complete Molecular Response For At Least One Year: Results From a Prospective Discontinuation (DADI) Trial International conference

    Tanaka H, Imagawa J, Okada M, Nakamae H, Hino M, Murai K, Ishida Y, Kumagai T, Sato S, Ohashi K, Sakamaki H, Wakita H, Uoshima N, Nakagawa Y, Minami Y, Ogasawara M, Takeoka T, Akasaka H, Morita S, Sakamoto J, Kimura S

    55th American Society of Hematology   2013.12 

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  • Gvhd Prophylaxis With Mycophenolate Mofetil and Calcineurin Inhibitor In Allogeneic Hematopoietic Cell Transplantation From HLA-Matched Siblings Or 7–8/8 HLA-Matched Unrelated Volunteer Donors: A Japanese, Multicenter, Phase II Trial International conference

    Nakane T, Nakamae H, Kurosawa S, Okamura A, Hidaka M, Yamashita T, Kohno A, Saito T, Aoyama Y, Hatanaka K, Katayama Y, Yakushijin K, Matsui T, Takami A, Yamaguchi T, Hino M, FukudaT

    55th American Society of Hematology   2013.12 

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  • A New Strategy Of MDS Treatment With Azacitidine (AZA): Induction With AZA Combined With Low Dose AraC Followed By Maintenance Therapy With AZA International conference

    Hirai M, Nakane T, Inoue A, Hashimura M, Aimoto M, Sakamoto E, Nakamae H, Hino M

    55th American Society of Hematology  2013.12 

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  • Diagnostic usefulness of a new in situ hybridization method for detection of global bacterial DNA in febrile neutropenia International conference

    Aimoto M, Koh, H, Matsuhisa A, Inoue S, Katayama T, Nagasaki J, Sakabe M, Okamura H, Yoshimura T, Inaba A, Koh S, Nanno S, Nishimoto M, Nakashima Y, Hirose A, Nakamae M, Hagihara K, Terada Y, Nakane T, Nakamae H, Hino M

    IDWeek 2013  2013.10 

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  • 血管内増殖性糸球体腎炎を合併する血管免疫芽球性T細胞リンパ腫(Angioimmunoblastic T cell lymphoma complicated by endocapillary proliferative glomerulonephritis) Domestic conference

    Nanno Satoru, Nakamae Hirohisa, Kuwamura Yukinobu, Ishimura Eiji, Sakabe Manami, Inaba Akiko, Koh Shiro, Yoshimura Takuro, Nishimoto Mitsutaka, Hayashi Yoshiki, Terada Yoshiki, Nakane Takahiko, Koh Hideo, Nakao Yoshitaka, Ohsawa Masahiko, Hino Masayuki

    臨床血液  2013.09  (一社)日本血液学会-東京事務局

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  • 有望な新規治療法 限局期形質転換FLに対する短期BR後のRT(New encouraging treatment strategy: Short cycles BR followed by RT for limited stage transformed FL) Domestic conference

    Terada Yoshiki, Inaba Akiko, Yoshida Atsushi, Kuwae Yuuko, Koh Hideo, Nakane Takahiko, Nakamae Hirohisa, Hosono Masako, Ohosawa Masahiko, Shiomi Susumu, Hino Masayuki

    臨床血液  2013.09  (一社)日本血液学会-東京事務局

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  • 新規診断CML-CPに対するnilotinibとimatinibの比較 日本人患者におけるENESTnd 48ヵ月時の最新情報(Nilotinib vs. imatinib for newly-diagnosed CML-CP: ENESTnd 48-month update in Japanese patients) Domestic conference

    Fukuda Tetsuya, Nakamae Hirohisa, Shibayama Hirohiko, Kurokawa Mineo, Nakaseko Chiaki, Kanda Yoshinobu, Nagai Tadashi, Ohnishi Kazunori, Matsumura Itaru, Matsuda Akira, Amagasaki Taro, Ito Kazuo

    臨床血液  2013.09  (一社)日本血液学会-東京事務局

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  • 同種造血細胞移植後の血球貪食症候群に関する危険因子(Risk factors for hemophagocytic syndrome following allogeneic hematopoietic cell transplantation) Domestic conference

    Nanno Satoru, Koh Hideo, Sakabe Manami, Nagasaki Joji, Okamura Hiroshi, Koh Shiro, Yoshimura Takuro, Inaba Akiko, Aimoto Mizuki, Nishimoto Mitsutaka, Hirose Asao, Nakamae Mika, Nakashima Yasuhiro, Hagihara Kiyoyuki, Nakao Yoshitaka, Nakane Takahiko, Terada Yoshiki, Nakamae Hirohisa, Hino Masayuki

    臨床血液  2013.09  (一社)日本血液学会-東京事務局

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  • 低用量ATG-Fを併用したuRIST 多施設共同第II相試験(uRIST with low-dose ATG-F: multicenter phase II trial) Domestic conference

    Fuji Shigeo, Kim Sung-Won, Yano Shingo, Hagiwara Shotaro, Nakamae Hirohisa, Hidaka Michihiro, Ito Toshiro, Ohashi Kazuteru, Hatanaka Kazuo, Takami Akiyoshi, Kurosawa Saiko, Yamashita Takuya, Yamaguchi Takuhiro, Fukuda Takahiro

    臨床血液  2013.09  (一社)日本血液学会-東京事務局

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  • アザシチジン治療中に急性白血病化した2例 Domestic conference

    平井 学, 坂本 恵利奈, 橋村 光晴, 井上 敦司, 相本 瑞樹, 市原 弘善, 中前 博久, 日野 雅之

    臨床血液  2013.09  (一社)日本血液学会-東京事務局

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  • Ph+白血病の日本人患者におけるponatinib第I/II相試験の予備的研究(Preliminary report of a phase 1/2 study of ponatinib in Japanese patients with Ph+ Leukemias) Domestic conference

    Tauchi Tetsuzo, Tojo Arinobu, Nakamae Hirohisa, Kobayashi Yukio, Okamoto Shinichiro, Miyamura Koichi, Kyo Taiichi, Iwasaki Hiromi, Hatake Kiyohiko, Usui Noriko, Narashimhan Narayana I., Hu Simin, Yanase Kumiko, Zhang Joshua, Naoe Tomoki, Ohyashiki Kazuma

    臨床血液  2013.09  (一社)日本血液学会-東京事務局

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  • GVHD患者への抗真菌薬予防に関するvoriconazoleとitraconazoleの比較(Voriconazole vs. itraconazole for antifungal prophylaxis in patients with GVHD: A randomized trial) Domestic conference

    Hayashi Yoshiki, Kanda Yoshinobu, Nakamae Hirohisa, Kanamori Heiwa, Ohashi Kazuteru, Hidaka Michihiro, Yano Shingo, Hatanaka Kazuo, Kohno Akio, Moriuchi Yukiyoshi, Ago Hiroatsu, Yamashita Takuya, Hino Masayuki, Yamaguchi Takuhiro, Fukuda Takahiro

    臨床血液  2013.09  (一社)日本血液学会-東京事務局

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    Presentation type:Oral presentation (general)  

  • dasatinib内服によりCMLクローンによると考えられる重度の骨髄抑制を脱した症例 Domestic conference

    中嶋 康博, 中前 博久, 坂部 真奈美, 西本 光孝, 康 秀男, 日野 雅之

    臨床血液  2013.09  (一社)日本血液学会-東京事務局

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  • Evans症候群発症後20年の経過を経てクームス陰性溶血性貧血を伴うDLBCLを合併した1例 Domestic conference

    吉村 卓朗, 中根 孝彦, 稲葉 晃子, 康 秀男, 中尾 吉孝, 中前 博久, 日野 雅之, 藤野 惠三, 向井 悟, 亀崎 豊実

    臨床血液  2013.08  (一社)日本血液学会-東京事務局

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  • 中枢病変に伴う尿崩症を合併した3q21q26および7染色体異常を有するAMLの1例 Domestic conference

    南野 智, 萩原 潔通, 坂部 真奈美, 稲葉 晃子, 西本 光孝, 康 秀男, 中前 博久, 日野 雅之, 永田 友貴, 下野 太郎

    臨床血液  2013.02  (一社)日本血液学会-東京事務局

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  • Tolerated, Low-Dose Deferasirox : Successful Three Cases of Aplastic Anemia and 34 Cases of MDS International conference

    Hirai M, Yamamura R, Nakamae H, Terada Y, Inoue A, Hashimura M, Ichihara H, Sakamoto E, Hino M

    54th American Society of Hematology  2012.12 

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  • Reduced-Intensity Versus Myeloablative Conditioning Allogeneic Hematopoietic Stem Cell Transplantation for Patients Aged Over 45 Years with Acute Lymphoblastic Leukemia (ALL) in Remission: A Study From the ALL Working Group of the Japan Society for Hematopoietic Cell Transplantation (JSHCT) International conference

    Tanaka J, Kanamori H, Nishiwaki S, Ohashi K, Taniguchi S, Nakamae H, Katayama Y, Morishima Y, Suzuki R, Kato K, Sakamaki H, Nishimoto N, Masauzi N

    54th American Society of Hematology  2012.12 

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    Presentation type:Poster presentation  

  • 同種造血幹細胞移植前および、移植後の血清フェリチン値が予後に与える影響の包括的検討 Domestic conference

    中前 美佳, 中前 博久, 康 秀男, 中根 孝彦, 廣瀬 朝生, 中嶋 康博, 日野 雅之

    臨床病理  2012.10  日本臨床検査医学会

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  • Usefulness of Procalcitonin and C-Reactive Protein as Diagnostic Markers of Bacterial Infection in Febrile Neutropenia International conference

    Aimoto M, Koh H, Bingo M, Yoshida M, Okamura H, Yoshimura T, Inaba A, Koh S, Nanno S, Nishimoto M, Hayashi Y, Hirose A, Nakamae M, Hagihara K, Terada Y, Nakane T, Nakamae H, Hino M

    52nd Interscience Conference on Antimicrobial Agents and Chemotherapy   2012.09 

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  • 血球貪食と合併したMDSを伴う急性線維素性器質性肺炎(AFOP)(Acute fibrinous and organizing pneumonia (AFOP) associated with MDS complicated by hemophagocytosis) Domestic conference

    Nanno Satoru, Koh Hideo, Manabe Masahiro, Yoshida Masahiro, Okamura Hiroshi, Bingo Masato, Koh Shiro, Yoshimura Takuro, Inaba Akiko, Aimoto Mizuki, Nishimoto Mitsutaka, Hayashi Yoshiki, Hirose Asao, Nakamae Mika, Hagihara Kiyoyuki, Nakao Yoshitaka, Nakane Takahiko, Terada Yoshiki, Nakamae Hirohisa, Ohsawa Masahiko, Hino Masayuki

    臨床血液  2012.09  (一社)日本血液学会-東京事務局

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  • 新規にCML-CPと診断された患者に対するnilotinibとimatinibの比較 日本人症例におけるPK解析を加えた36ヵ月の経過報告(Nilotinib vs. imatinib for newly-diagnosed CML-CP: 36-month update with PK analysis in Japanese pts) Domestic conference

    Kanda Yoshinobu, Nakamae Hirohisa, Shibayama Hirohiko, Kurokawa Mineo, Nakaseko Chiaki, Fukuda Tetsuya, Nagai Tadashi, Ohnishi Kazunori, Matsumura Itaru, Matsuda Akira, Amagasaki Taro, Kojo Naoko, Kawahara Eiji

    臨床血液  2012.09  (一社)日本血液学会-東京事務局

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  • 大腿部打撲傷に続発した慢性GVHD関連多発性筋炎と肝炎(Chronic GVHD-related polymyositis and hepatitis that occurred subsequent to a bruise of the thigh) Domestic conference

    Koh Shiro, Koh Hideo, Sakabe Manami, Yoshida Masahiro, Okamura Hiroshi, Inaba Akiko, Bingo Masato, Yoshimura Takuro, Nanno Satoru, Nishimoto Mitsutaka, Hayashi Yoshiki, Hirose Asao, Nakamae Mika, Hagihara Kiyoyuki, Nakane Takahiko, Terada Yoshiki, Nakamae Hirohisa, Ohsawa Masahiko, Hino Masayuki

    臨床血液  2012.09  (一社)日本血液学会-東京事務局

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  • アザシチジン治療を行った24症例 Domestic conference

    平井 学, 百瀬 大, 橋村 光晴, 井上 敦司, 市原 弘善, 坂本 恵利奈, 朴 勤植, 高 起良, 中尾 吉孝, 萩原 潔通, 中根 孝彦, 山根 隆久, 中前 博久, 日野 雅之

    臨床血液  2012.09  (一社)日本血液学会-東京事務局

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  • 移植後汎血球減少を来たした骨髄パルボウィルス感染症の1例 Domestic conference

    吉村 卓朗, 中根 孝彦, 岡村 浩史, 稲葉 晃子, 康 史朗, 南野 智, 西本 光孝, 康 秀男, 中前 博久, 日野 雅之

    臨床血液  2012.08  (一社)日本血液学会-東京事務局

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  • 臍帯血移植後に心タンポナーデを発症し心嚢液からHHV-6DNAが検出された1例 Domestic conference

    吉田 全宏, 康 秀男, 岡村 浩史, 備後 真登, 西本 光孝, 林 良樹, 間部 賢寛, 中根 孝彦, 中前 博久, 日野 雅之

    臨床血液  2012.01  (一社)日本血液学会-東京事務局

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  • Risk Factors Affecting Cardiac Left Ventricular Systolic and Diastolic Function and Hypertrophy in the Chronic Phase Post-Allogeneic Hematopietic Cell Transplantation International conference

    Nishimoto M, Nakamae H, Nakane T, Koh H, Hayashi Y, Nakamae M, Yoshida M, Bingo M, Okamura H, Aimoto M, Manabe M, Yoshimura T, Inaba A, Nanno S, Hirose A, Hagihara K, Nakao Y, Terada Y, Hino M

    53th American Society of Hematology   2011.12 

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  • Fludarabine-Based Reduced Intensity Hematopoietic Stem Cell Transplantation (RIST) for Patients Aged 50-70 Years with Acute Lymphoblastic Leukemia (ALL) in Remission: A Study From the ALL Working Group of the Japan Society for Hematopoietic Cell Transplantation (JSHCT) International conference

    Kanamori H, Kako S, Kato H, Nishiwaki S, Furukawa T, Saito M, Taniguchi S, Nakamae H, Yujiri T, Naganuma-Inoue T, Morishima Y, Suzuki R, Sakamaki H, Tanaka J

    53th American Society of Hematology  2011.12 

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  • Nilotinib Versus Imatinib in Patients (pts) with Newly Diagnosed Philadelphia Chromosome-Positive (Ph+) Chronic Myeloid Leukemia in Chronic Phase (CML-CP): ENESTnd 36-Month (mo) Follow-up International conference

    Saglio G, LeCoutre PD, Pasquini R, Jootar S, Nakamae H, Flinn IW, Hochhaus A, Hughes TP, Larson RA, Hoenekopp A, Gallagher NJ, Yu R, Blakesley RE, Kim DW, Kantarjian HM

    53th American Society of Hematology  2011.12 

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  • Immunoprofile of Patients with Chronic Myeloid Leukemia Treated with Imatinib, Nilotinib or Dasatinib International conference

    Hayashi Y, Nakamae H, Katayama T, Nakane T, Koh H, Nishimoto M, Nakamae M, Yoshida M, Bingo M, Okamura H, Aimoto M, Manabe M, Yoshimura T, Inaba A, Nanno S, Hagihara K, Nakao Y, Terada Y, Hino M

    53th American Society of Hematology   2011.12 

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  • 高感度IS-Q-PCR検査によるCML-CPのCMR/MMR比を評価する多施設共同臨床試験(Multi-center clinical study evaluating the CMR/MMR ratio of CML-CP by high-sensitive IS-Q-PCR test) Domestic conference

    Nishiwaki Kaichi, Takahashi Naoto, Wakita Hisashi, Shinohara Yoshinori, Takahara Shinobu, Sano Koji, Masuoka Hidekazu, Aotsuka Nobuyuki, Matsuura Yasuhiro, Hirasawa Akira, Nakamura Hirotoshi, Kashimura Makoto, Fukazawa Motoharu, Tanaka Hiroaki, Nakagawa Yasunori, Matsue Kosei, Itoh Kuniaki, Hatano Yoshiaki, Kuroki Jun, Nakayama Yutaka, Ichikawa Yoshikazu, Chubachi Akihiko, Nimura Takashi, Motegi Mutsuhito, Mugitani Atsuko, Nakane Takahiko, Nakamae Hirohisa, Hino Masayuki, Sawada Kenichi, Miyazaki Yasushi, The Shimousa Hematology Study Group

    臨床血液  2011.09  (一社)日本血液学会-東京事務局

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  • 白血病患者1例における急性膵炎後に発症した可逆性後白質脳症(Reversible posterior leukoencephalopathy following acute pancreatitis in a patient with leukemia) Domestic conference

    Nishimoto Mitsutaka, Koh Hideo, Hayashi Yoshiki, Manabe Masahiro, Bingo Masato, Yoshida Masahiro, Okamura Hiroshi, Hirose Asao, Nakamae Mika, Hagihara Kiyoyuki, Nakane Takahiko, Terada Yoshiki, Nakamae Hirohisa, Hino Masayuki

    臨床血液  2011.09  (一社)日本血液学会-東京事務局

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  • 新規診断CML-CPに対するnilotinib対imatinibの比較 日本人患者におけるENESTndの24ヵ月時最新結果(Nilotinib versus imatinib for newly-diagnosed CML-CP: ENESTnd 24-month update in Japanese patients) Domestic conference

    Nakaseko Chiaki, Nakamae Hirohisa, Shibayama Hirohiko, Kurokawa Mineo, Fukuda Tetsuya, Kanda Yoshinobu, Nagai Tadashi, Ohnishi Kazunori, Matsumura Itaru, Matsuda Akira, Amagasaki Taro, Kojo Naoko, Ito Kazuo, AMN107/2303 Study Group

    臨床血液  2011.09  (一社)日本血液学会-東京事務局

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  • 慢性期CMLの新規診断患者でのdasatinib対imatinibの比較 日本人におけるサブ解析(Dasatinib versus imatinib in patients with newly diagnosed chronic-phase CML: Japanese sub-analysis) Domestic conference

    Ogura Michinori, Nakamae Hirohisa, Fujisawa Shin, Ishizawa Ken-ichi, Taniwaki Masafumi, Utsunomiya Atae, Matsue Kosei, Tamura Kazuo, Usuki Kensuke, Tanimoto Mitsune, Ishida Yoji, Akiyama Hideki, Sakai Rika, Kasai Masanobu, Hino Masayuki, Takeyama Kunihiko, Seriu Taku, Bradley-Garelik M. Brigid, Zhu Chao, Dasatinib Study Group

    臨床血液  2011.09  (一社)日本血液学会-東京事務局

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  • 同種骨髄移植後に再発したMDSの1症例におけるcold-AIHA(Cold-AIHA in a case of MDS relapsed after allogenic bone marrow transplantation) Domestic conference

    Okamura Hiroshi, Nakane Takahiko, Yoshida Masahiro, Bingo Masato, Aimoto Mizuki, Nishimoto Mitutaka, Hayashi Yoshiki, Manabe Masahiro, Koh Hideo, Nakamae Mika, Terada Yoshiki, Nakamae Hirohisa, Hino Masayuki

    臨床血液  2011.09  (一社)日本血液学会-東京事務局

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  • 同種造血細胞移植後の血球貪食症候群における血清サイトカインプロフィール(Serum cytokine profiles in hemophagocytic syndrome after allogeneic hematopoietic cell transplant) Domestic conference

    Koh Hideo, Koh Ki-Ryang, Nakane Takahiko, Sakamoto Erina, Katayama Takako, Nakamae Mika, Terada Yoshiki, Nakamae Hirohisa, Yamane Takahisa, Hino Masayuki

    臨床血液  2011.09  (一社)日本血液学会-東京事務局

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  • ヒトT細胞性白血病ウイルス1型を伴わない原発性胃T細胞性リンパ腫 1症例報告(Primary gastric T-cell lymphoma without Human T-cell Leukemia Virus Type 1: a case report) Domestic conference

    Manabe Masahiro, Yamane Takahisa, Inaba Akiko, Nanno Satoru, Inoue Atsushi, Aimoto Mizuki, Okamura Hiroshi, Yoshida Masahiro, Bingo Masato, Nishimoto Mitsutaka, Hayashi Yoshiki, Koh Hideo, Nakane Takahiko, Nakamae Mika, Hagihara Kiyoyuki, Terada Yoshiki, Nakamae Hirohisa, Nakao Yoshitaka, Nakamura Masanori, Muguruma Kazuya, Ohsawa Masahiko, Hino Masayuki

    臨床血液  2011.09  (一社)日本血液学会-東京事務局

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  • Imatinib、nilotinib、dasatinib治療を受けたCML患者の免疫プロファイル(The Immunoprofile of patients with CML treated with imatinib, nilotinib or dasatinib) Domestic conference

    Hayashi Yoshiki, Nakamae Hirohisa, Katayama Takako, Nakane Takahiko, Koh Hideo, Nishimoto Mitsutaka, Nakamae Mika, Yoshida Masahiro, Bingo Masato, Okamura Hiroshi, Aimoto Mizuki, Manabe Masahiro, Hagihara Kiyoyuki, Nakao Yoshitaka, Terada Yoshiki, Hino Masayuki

    臨床血液  2011.09  (一社)日本血液学会-東京事務局

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  • CD7+、CD56+、Ph陽性早期前駆細胞B-ALLの稀な1症例(A rare case of CD7+, CD56+ and Ph-positive early precursor B-ALL) Domestic conference

    Yoshida Masahiro, Nakane Takahiko, Okamura Hiroshi, Bingo Masato, Aimoto Mizuki, Nishimoto Mitsutaka, Hayashi Yoshiki, Manabe Masahiro, Koh Hideo, Hagihara Kiyoyuki, Nakamae Mika, Terada Yoshiki, Nakamae Hirohisa, Hino Masayuki

    臨床血液  2011.09  (一社)日本血液学会-東京事務局

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  • 非血縁者間同種造血幹細胞移植後、自律神経障害を呈したHHV6脳炎・脊髄炎の1例 Domestic conference

    西本 光孝, 中前 博久, 林 良樹, 間部 賢寛, 康 秀男, 中根 孝彦, 廣瀬 朝生, 中前 美佳, 寺田 芳樹, 日野 雅之

    臨床血液  2011.08  (一社)日本血液学会-東京事務局

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  • Factors That Contribute to Long-Term Survival In Patients with Leukemia Not In Remission at Allogeneic Hematopoietic Cell Transplantation International conference

    Koh H, Nakamae H, Nakane T, Manabe M, Hayashi Y, Nishimoto M, Umemoto K, Nakamae M, Hirose A, Inoue E, Inoue A, Yoshida M, Bingo M, Okamura H, Aimoto R, Aimoto M, Terada Y, Koh KR, Yamane T, Hino M

    52th American Society of Hematology  2010.12 

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  • HLA一致同胞からの骨髄移植後再燃の重症再生不良性貧血に対し、同一ドナーからRIC-PBSCTを施行した一例 Domestic conference

    林 良樹, 中根 孝彦, 中前 博久, 康 秀男, 中前 美佳, 西本 光孝, 井上 恵里, 井上 敦司, 相本 蘭, 相本 瑞樹, 吉田 全宏, 寺田 芳樹, 高 起良, 山根 孝久, 日野 雅之

    臨床血液  2010.09  (一社)日本血液学会-東京事務局

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  • 新規に診断された慢性期の慢性骨髄性白血病におけるダサチニブとイマチニブの比較(Dasatinib compared with imatinib in newly diagnosed chronic myelogenous leukemia in chronic phase) Domestic conference

    Nakamae Hirohisa, Shah Neil, Hochhaus Andreas, Cortes Jorge, Shah Sandip, Ayala Manuel, Moiraghi Beatriz, Bradley-Garelik M. Brigid, Zhu Chao, Baccarani Michele, Kantarjian Hagop

    臨床血液  2010.09  (一社)日本血液学会-東京事務局

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  • 新規に診断されたCML-CPの日本人患者におけるニロチニブとイマチニブの有効性と安全性の比較(Efficacy and safety of nilotinib versus imatinib in Japanese patients with newly diagnosed CML-CP) Domestic conference

    Shibayama Hirohiko, Nakamae Hirohisa, Kurokawa Mineo, Fukuda Tetsuya, Nakaseko Chiaki, Kanda Yoshinobu, Ohnishi Kazunori, Matsuda Akira, Nagai Tadashi, Maeda Yasuhiro, Amagasaki Taro, Kawahara Eiji, Yanada Masamitsu

    臨床血液  2010.09  (一社)日本血液学会-東京事務局

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  • 新規に診断されたCML-CPに対するニロチニブおよびイマチニブ治療時のBCR-ABLレベルの変化(Change of BCR-ABL levels during nilotinib and imatinib treatment for newly diagnosed CML-CP) Domestic conference

    Imai Yoichi, Nakamae Hirohisa, Shibayama Hirohiko, Fukuda Tetsuya, Nakaseko Chiaki, Kanda Yoshinobu, Ohnishi Kazunori, Matsuda Akira, Nagai Tadashi, Maeda Yasuhiro, Amagasaki Taro, Kawahara Eiji, Yanada Masamitsu

    臨床血液  2010.09  (一社)日本血液学会-東京事務局

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  • クローン病治療中に発症した、CD13、33陰性の急性骨髄単球性白血病の1例 Domestic conference

    西本 光孝, 中前 博久, 井上 敦司, 井上 恵理, 相本 蘭, 相本 瑞樹, 林 良樹, 康 秀男, 中根 孝彦, 廣瀬 朝生, 中前 美佳, 寺田 芳樹, 高 起良, 山根 孝久, 渡辺 憲治, 日野 雅之

    臨床血液  2010.09  (一社)日本血液学会-東京事務局

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  • B細胞性急性リンパ性白血病の同種造血幹細胞移植後の髄外再発に対してBlinatumomabとドナーリンパ球輸注の併用療法で長期生存を獲得した1例 Domestic conference

    第241回 日本内科学会近畿地方会 

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Industrial Property Rights

  • 造血幹細胞移植後の合併症リスクの検出方法,予防診断薬及びキット

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    property_type:Patent 

    Application no:2020-015285 

  • スキルス性胃癌の治療剤、及び胃癌の予後の予測方法

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    property_type:Patent 

    Application no:2016-098055 

  • プレセプシン測定による発熱性好中球減少症の診断

    中前博久、康 秀男

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    property_type:Patent 

    Application no:PCT/JP2014/061897 

    Announcement no:WO2014178383A1 

    Publication no:WO2014178383A1 

Grant-in-Aid for Scientific Research

  • PTCyによる造血細胞移植の国際標準化に向けて:抗腫瘍効果を効果的に誘導するには?

    Grant-in-Aid for Scientific Research(C)  2023

  • 移植前検査に基づく造血幹細胞移植後の予後予測モデルの開発

    Grant-in-Aid for Scientific Research(C)  2023

  • 血液疾患コホートを利用した治療標的分子探索および数理モデリングによる病態解析

    2022

  • 移植前検査に基づく造血幹細胞移植後の予後予測モデルの開発

    Grant-in-Aid for Scientific Research(C)  2022

  • 移植前検査に基づく造血幹細胞移植後の予後予測モデルの開発

    Grant-in-Aid for Scientific Research(C)  2020.04

  • 血液疾患コホートを利用した治療標的分子探索および数理モデリングによる病態解析

    Grant-in-Aid for Scientific Research(C)  2020.04

  • スキルス胃癌組織構築機序の解明と治療開発:骨髄細胞と癌幹細胞による間質形成の解析

    Grant-in-Aid for Scientific Research(B)  2018.04

  • 造血幹細胞移植治療の合併症克服と有効率向上に関する研究

    Grant-in-Aid for Scientific Research(C)  2011.04

  • 造血幹細胞移植後の急性移植片対宿主病、非感染性肺合併症の予測、予防に関する研究

    Grant-in-Aid for Scientific Research(C)  2010.04

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Joint research

  • 造血幹細胞移植後患者における、ウェアラブルデバイスとモバイルアプリケーションを用いた移植合併症予測支援システムの開発と外来フォローアップ体制の構築

    国立研究開発法人日本医療研究開発機構  予防・健康づくりの社会実装に向けた研究開発基盤整備事業(健康・医療情報活用技術開発課題)  2023.04

  • アグレッシブ成人T細胞白血病リンパ腫を対象とした全国一元化レジストリ・バイオレポジトリ研究

    国立研究開発法人日本医療研究開発機構  革新的がん医療実用化研究事業(日本医療研究開発機構研究費)  2023.04

  • 成人T細胞白血病に対する移植後シクロフォスファミドを用いた非血縁者間末梢血幹細胞移植法の確立と移植後再発への対策に関する研究

    国立研究開発法人日本医療研究開発機構  革新的がん医療実用化研究事業(日本医療研究開発機構研究費)  2020.04

Contract research

  • Analysis of cellular, humoral immune abnormality and immunological modulation of tumor microenvironment during development of plasma cell line tumor

    2019.07

  • 発熱性好中球減少症における末梢血プレセプシン動態の前方視的検討

    2013.11

  • 骨髄移植患者のおけるプレセプシンに関する検討

    2012.11

Incentive donations / subsidies

  • 難治性造血器悪性腫瘍に対するHLA半合致同種造血幹細胞移植

    公益財団法人 がん集学的治療研究財団   2013

Other subsidies, etc.

  • 革新的GVHD予防法による造血幹細胞移植のドナープールの拡大と予後改善のためのGVHD予防機序の解明

    財団法人 日本対がん協会  2022年度リレー・フォー・ライフ・ジャパン(RFLJ) 「プロジェクト未来」研究助成金  2022.12

  • 成人T細胞白血病に対する移植後シクロフォスファミドを用いた非血縁者間末梢血幹細胞移植法の確立と移植後再発への対策に関する研究

    国立研究開発法人日本医療研究開発機構  日本医療研究開発機構研究費  2020.04

  • 急性骨髄性白血病幹細胞を標的としたCAR T細胞療法の開発

    厚生労働省  2019.04

  • 急性型およびリンパ腫型成人T細胞白血病に対する標準治療としての同種造血幹細胞移植法の確立

    厚生労働省  2017.04

  • 成人T細胞白血病に対する標準治療としての同種造血幹細胞移植法の確立およびゲノム解析に基づく治療法の最適化に関する研究

    国立研究開発法人日本医療研究開発機構   2015.04

  • 成人T細胞白血病に対する標準治療としての同種造血幹細胞移植法の確立およびゲノム解析に基づく治療法の最適化に関する研究

    厚生労働省  2014.04

  • 難治性造血器腫瘍に対する造血幹細胞移植の治療成績向上を目指した未承認・適応外薬のエビデンス確立に関する研究

    厚生労働省  2013.04

  • 造血幹細胞移植の有効性と安全性向上のための薬剤のエビデンスの確立に関する研究

    厚生労働省  2010.04

  • BDPによる消化管GVHDの早期介入

    財団法人 臨床薬理研究振興財団  2010

  • 同種造血幹細胞移植後の遅発性非感染症肺合併症の予測因子の確立

    財団法人 大阪対ガン協会   2005

  • 同種造血幹細胞移植後の遅発性非感染症 肺合併症の予測因子の確立

    財団法人 大阪対ガン協会  ガン研究助成奨励金  2005

  • 造血器悪性腫瘍に対する超大量化学療法に伴う心不全予測因子の解析

    財団法人 大阪対ガン協会  ガン研究助成奨励金  2000

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Original item・Special report (Research Activity)

  • 2023

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    Original item:国際共同治験を責任医師16試験、分担医師39試験を施行

  • 2022

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    Original item:国際共同治験を責任医師15試験、分担医師38試験を施行

Charge of on-campus class subject

  • Practice in clinical research planning

    2023     Graduate school

  • M4 ユニット型臨床臓器別講義(血液・造血器)

    2023     Undergraduate

  • 血液内科 M5ユニット型CC

    2023     Undergraduate

  • 臨床検査・情報

    2023     Undergraduate

  • Practice in clinical research planning

    2022     Graduate school

  • M4ユニット型臨床臓器別講義(血液・造血器)

    2022     Undergraduate

  • 臨床病態学(血液代謝内分泌系)

    2022     Graduate school

  • 血液内科 M5ユニット型CC

    2022     Undergraduate

  • 血液内科

    2021     Graduate school

  • 血液内科

    2021     Undergraduate

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Number of papers published by graduate students

  • 2023

    Number of graduate students presentations:5

  • 2022

    Number of graduate students presentations:2

Original item・Special report (Education Activity)

  • 2023

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    Original item:阪神5大学サステナブル がん人材育成プラン委員(TF3)として大学院の指導に従事

  • 2023

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    Original item:日本血液学会血液指導医としての血液疾患診療の指導

  • 2022

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    Original item:日本血液学会血液指導医としての血液疾患診療の指導

Social Activities

  • 移植拠点病院セミナー

    Role(s): Lecturer

    大阪公立大学医学部附属病院  血液内科・造血細胞移植科  2024.03

  • 市民公開講座

    Role(s): Lecturer

    ブリストル・マイヤーズ スクイブ株式会社 慢性骨髄性白血病患者・家族の会 いずみの会  2022.03

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    Type:Lecture

  • 東成区医師会生涯教育講演会

    Role(s): Lecturer

    東成区医師会・大塚製薬株式会社  2021.02

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    Type:Lecture

    Number of participants:20(人)

    CML治療の発展の歴史について講演

  • 移植拠点病院セミナー

    Role(s): Lecturer

    大阪市立大学医学部附属病院  血液内科・造血細胞移植科  2016.08

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    Type:Seminar, workshop

    PT/CYを用いた同種造血細胞移植の現状と今後の展望について講演を行う。

  • 移植拠点病院セミナー

    Role(s): Lecturer

    大阪市立大学医学部附属病院  血液内科・造血細胞移植科  2016.01

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    Type:Seminar, workshop

    Post CY大量療法によるハプロ移植の講演を行う。

  • 移植拠点病院セミナー

    Role(s): Lecturer

    大阪市立大学医学部附属病院  血液内科・造血細胞移植科  2014.10

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    Type:Seminar, workshop

    再発後治療・再移植ドナーの選択について講演を行う。

  • 第155回 大阪市市民講座 講演

    Role(s): Lecturer

    2011.09

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    Audience: General public

    Type:Lecture

    Number of participants:134(人)

    :骨髄移植について市民に向けた分かりやすい講演を行った。

  • つばさの会 講演

    Role(s): Lecturer

    患者会 つばさの会   2011.06

     More details

    Audience: General public

    Type:Lecture

    移植療法の基本理解について一般の方、患者さんに向けた分かりやすい講演を行った。

  • 日本骨髄バンク調整医師

    Role(s): Logistic support

    公益財団法人 日本骨髄バンク  2009.06 - Now

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    Type:Other

  • 第13回医療セミナー 悪性リンパ腫における造血幹細胞移植の位置づけ

    Role(s): Lecturer

    ネクサス  2006.09

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Academic Activities

  • 論文査読

    Role(s): Peer review

    2023.04 - 2024.03

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    Type:Peer review 

  • Frontires In Oncology Associate Editor

    2023.04 - 2024.03

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    Type:Peer review 

  • Frontires In Oncology Associate Editor

    Role(s): Peer review

    2022.04 - 2023.03

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    Type:Peer review 

International exchange activities

  • 28th Congress of Asia-Pacific Blood and Marrow Transplantation(APBMT 2023)

    Field category :Research

    Country name :Indonesia   2023.10

  • 海外留学生として台湾大学から医学部生1名の短期臨床実習を受け入れ、指導を行った。

    Field category :Education

    Country name :台湾   2023.10

Job title

  • Job title within the department

    School of Medicine 附属病院 血液内科・造血細胞移植科 

    2023.04 - 2024.03

  • Job title within the department

    School of Medicine 附属病院 血液内科・造血細胞移植科 

    2022.04 - 2023.03

  • Manager within the university

    2012.10

  • Manager within the university

    2011.04

Original item / Special report (Management administration)

  • 2020

      More details

    Original item:日本臨床検査医学会臨床検査管理医