Updated on 2023/11/14

写真a

 
AZUMA Hideki
 
Organization
Graduate School of Engineering Division of Science and Engineering for Materials, Chemistry and Biology Lecturer
School of Engineering Department of Chemistry and Bioengineering
Title
Lecturer
Affiliation
Institute of Engineering

Position

  • Graduate School of Engineering Division of Science and Engineering for Materials, Chemistry and Biology 

    Lecturer  2022.04 - Now

  • School of Engineering Department of Chemistry and Bioengineering 

    Lecturer  2022.04 - Now

Degree

  • 博士(工学) ( Osaka City University )

Research Areas

  • Nanotechnology/Materials / Synthetic organic chemistry

  • Nanotechnology/Materials / Bio chemistry

Research Interests

  • antitumor

  • cyclodextrin

  • folic acid

  • anthraquinone

  • endocytosis

Research subject summary

  •  沖縄産の二枚貝の一種 Fragum sp. の共生藻より、Ca2+-ATPaseの作用を活性化する物質として、セラミドの一種であるシンビオラミドが三菱化成生命科学研の小林らによって分離された。Ca2+-ATPaseは、筋小胞体にあって、Ca2+を小胞体中に輸送し、動物の筋収縮において作用する重要な酵素である。  シンビオラミドの構造はアミノアルコール部分(Amino part)がD-エリトロ-ジヒドロスフィンゴシン、脂肪酸部分(Acid part)が2-ヒドロキシ-3-オクタデセン酸である。シンビオラミドの合成方法はいくつか報告されているが、本研究ではAmino part及びAcid part両方をL-セリンから合成した。現在、この化合物を用い、各種細胞に対するアポトーシス誘導効果等の生理活性を調べている。

Research Career

  • リパーゼを用いたシコニン/アルカンニンの光学分割

    リパーゼ 

    2016.04 - Now 

  • Enhancing effect of the metabolite of 1'-acetoxychavicol acetate (ACA) on Photodynamic Therapy

    Acetoxychavicol acetate, Glutathione, Photodynamic therapy  Joint Research in Japan

    2014.04 - Now 

  • 中国産紫根からのシコニンの抽出

    シコニン  Joint Research in Japan

    2014.03 - 2015.03 

  • Combination effect of S-allyl-cysteine derivative and various anti-inflammatory agents on the suppression of macrophage activation

    Allylcysteine, macrophage, antiinflammation  Joint Research in Japan

    2013.04 

  • Synthesis and bioactivity of the marine sphingolipids.

    Marine sphingolipid, Antitumor, Apoptosis  Individual

    2013.04 

  • Lipase-catalyzed Preparation of Optically Active 1'-Acetoxychavicol Acetates and their Structure-Activity Relationships in Apoptotic Activity Against Human Leukemia HL-60 Cells

    Lipase, Apoptosis  Joint Research in Organization

    2004.04 - 2005.03 

Professional Memberships

  • The Chemical Society of Japan

      Domestic

  • The Society of Synthetic Organic Chemistry, Japan

      Domestic

Committee Memberships (off-campus)

  • Officer of Kansai Branch   The Society of Synthetic Organic Chemistry, Japan  

    2012.04 - Now 

Papers

  • Lipase-catalyzed Preparation of Optically Active 1'-Acetoxychavicol Acetates and their Structure-Activity Relationships in Apoptotic Activity Against Human Leukemia HL-60 Cells

    K. Miyasaka, T. Yokotani, T. Tachibana, A. Kojima-Yuasa, I. Matsui-Yuasa, K. Ogino

    Bioorg. Med. Chem.   14   1811 - 1818   2007

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    Publishing type:Research paper (scientific journal)  

  • HER-2-targeted boron neutron capture therapy using an antibody-conjugated boron nitride nanotube/β-1,3-glucan complex Reviewed

    Keita Yamana, Riku Kawasaki, Kousuke Kondo, Hidetoshi Hirano, Shogo Kawamura, Yu Sanada, Kaori Bando, Anri Tabata, Hideki Azuma, Takushi ta, Yoshinori Sakurai, Hiroki Tanaka, Tomoki KTakaodama, Seiji Kawamoto, Takeshi Nagasaki, Atsushi Ikeda

    Nanoscale Advances   5   3857 - 3861   2023.06

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    International / domestic magazine:International journal  

    DOI: 10.1039/D3NA00028A

    Other URL: https://pubs.rsc.org/en/content/articlelanding/2023/na/d3na00028a

  • Carborane bearing pullulan nanogel-boron oxide nanoparticle hybrid for boron neutron capture therapy

    Kawasaki R.

    Nanomedicine: Nanotechnology, Biology, and Medicine   49   2023.04( ISSN:15499634

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  • A new “Mitsunobu homocoupling” reaction using aldol adducts of kojic acid Reviewed

    Hideki Azuma, Yasuhito Morishima, Keijin Nakaguro, Reiko Kato, Takeshi Nagasaki

    Tetrahedron   94   132314   2021.06

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    Publishing type:Research paper (scientific journal)   Kind of work:Single Work  

  • S-allyl-glutathione suppresses liver fibrosis by inhibition of excess skewing polarization of macrophages in rats Reviewed

    Minamiyama Yukiko, Takemura Shigekazu, Azuma Hideki, Osada-Oka Mayuko, Toda Michihito, Kobayashi Hikaru Keiko, Miyamoto, Ichikawa Hiroshi, Kubo Shoji

    FREE RADICAL BIOLOGY AND MEDICINE   120   S133 - S133   2018.05( ISSN:0891-5849

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.freeradbiomed.2018.04.439

  • S-allyl-glutathione improves liver fibrosis by inhibition of excess M1-or M2-polarized macrophage in rats. Reviewed

    Takemura Shigekazu, Minamiyama Yukiko, Azuma Hideki, Osada-Oka Mayuko, Kubo Shoji

    HEPATOLOGY   66   220A - 220A   2017.10( ISSN:0270-9139

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    Publishing type:Research paper (scientific journal)  

  • Improved isolation procedure for shikonin from the root of the Chinese medicinal plant Lithospermum erythrorhizon and its solubilization with cyclodextrins Reviewed

    Azuma Hideki, Li Jiawei, Youda Ryota, Suzuki Toshio, Miyamoto Kazuhide, Taniguchi Taizo, Nagasaki Takeshi

    JOURNAL OF APPLIED RESEARCH ON MEDICINAL AND AROMATIC PLANTS   3 ( 2 )   58 - 63   2016.05( ISSN:2214-7861

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.jarmap.2016.01.002

  • Anti-inflammatory effect of water-soluble complex of 1 '-acetoxychavicol acetate with highly branched beta-1,3-glucan on contact dermatitis Reviewed

    Li Jiawei, Aizawa Yui, Hiramoto Keiichi, Kasahara Emiko, Tsuruta Daisuke, Suzuki Toshio, Ikeda Atsushi, Azuma Hideki, Nagasaki Takeshi

    BIOMEDICINE & PHARMACOTHERAPY   69   201 - 207   2015.02( ISSN:0753-3322

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.biopha.2014.11.026

  • Therapeutic administration of an ingredient of aged-garlic extracts, <i>S</i>-allyl cysteine resolves liver fibrosis established by carbon tetrachloride in rats Reviewed

    Kodai Shintaro, Takemura Shigekazu, Kubo Shoji, Azuma Hideki, Minamiyama Yukiko

    SOCIETY FOR FREE RADICAL RESEARCH JAPAN Journal of Clinical Biochemistry and Nutrition   0 ( 0 )   2015( ISSN:0912-0009

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    Publishing type:Research paper (scientific journal)  

    <i>S</i>-allyl cysteine (SAC) is the most abundant compound in aged garlic extracts (AGEs). AGE has been reported to ameliorate the oxidative damage implicated in a variety of diseases. However, the effects of SAC have not been established in liver cirrhosis. The aim of this study was to examine the effect of therapeutic administration of SAC in liver cirrhosis by chronic carbon tetrachloride (CCl<sub>4</sub>) administration in rats. SAC or other cysteine compounds were administered from 4 weeks when liver fibrosis was confirmed to be in process. CCl<sub>4</sub> administration elevated plasma alanine aminotransferase, plasma lipid peroxidation, liver hydroxyproline, and liver transforming growth factor (TGF)-β at 12 weeks. SAC prevented these changes induced by CCl<sub>4</sub>. Furthermore, SAC improved survival in a dose-dependent manner following consecutive CCl<sub>4</sub> administration. The inhibitory mechanisms may be associated with a decrease in the profibrogenic cytokine, TGF-β as well as the antioxidative properties of SAC.

    DOI: 10.3164/jcbn.14-108

    CiNii Article

  • The synergistic effect of 1 '-acetoxychavicol acetate and sodium butyrate on the death of human hepatocellular carcinoma cells Reviewed

    Kato Rie, Matsui-Yuasa Isao, Azuma Hideki, Kojima-Yuasa Akiko

    CHEMICO-BIOLOGICAL INTERACTIONS   212   1 - 10   2014.04( ISSN:0009-2797

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.cbi.2014.01.010

  • S-Allyl cysteine improves nonalcoholic fatty liver disease in type 2 diabetes Otsuka Long-Evans Tokushima Fatty rats via regulation of hepatic lipogenesis and glucose metabolism Reviewed

    Takemura Shigekazu, Minamiyama Yukiko, Kodai Shintaro, Shinkawa Hiroji, Tsukioka Takuma, Okada Shigeru, Azuma Hideki, Kubo Shoji

    SOCIETY FOR FREE RADICAL RESEARCH JAPAN JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION   53 ( 2 )   94 - 101   2013.09( ISSN:0912-0009

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    Publishing type:Research paper (scientific journal)  

    It is important to prevent and improve diabetes mellitus and its complications in a safe and low-cost manner. <i>S</i>-Allyl cysteine, an aged garlic extract with antioxidant activity, was investigated to determine whether <i>S</i>-allyl cysteine can improve type 2 diabetes in Otsuka Long-Evans Tokushima Fatty rats with nonalcoholic fatty liver disease. Male Otsuka Long-Evans Tokushima Fatty rats and age-matched Long-Evans Tokushima Otsuka rats were used and were divided into two groups at 29 weeks of age. <i>S</i>-Allyl cysteine (0.45% diet) was administered to rats for 13 weeks. Rats were killed at 43 weeks of age, and detailed analyses were performed. <i>S</i>-Allyl cysteine improved hemoglobinA1c, blood glucose, triglyceride, and low-density lipoprotein cholesterol levels. Furthermore, <i>S</i>-allyl cysteine normalized plasma insulin levels. <i>S</i>-Allyl cysteine activated the mRNA and protein expression of both peroxisome proliferator-activated receptor α and γ, as well as inhibiting pyruvate dehydrogenase kinase 4 in Otsuka Long-Evans Tokushima Fatty rat liver. Sterol regulatory element-binding protein 1c and forkhead box O1 proteins were normalized by <i>S</i>-allyl cysteine in Otsuka Long-Evans Tokushima Fatty rat liver. In conclusions, these findings support the hypothesis that <i>S</i>-allyl cysteine has diabetic and nonalcoholic fatty liver disease therapeutic potential as a potent regulating agent against lipogenesis and glucose metabolism.

    DOI: 10.3164/jcbn.13-1

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  • The synergistic effect of 1 '-acetoxychavicol acetate and sodium butyrate on cell death of human hepatocellular carcinoma cells Reviewed

    Kato Rie, Matsui-Yuasa Isao, Azuma Hideki, Kojima-Yuasa Akiko

    FASEB JOURNAL   27   2013.04( ISSN:0892-6638

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    Publishing type:Research paper (scientific journal)  

  • HVJ-E/importin-beta hybrid vector for overcoming cytoplasmic and nuclear membranes as double barrier for non-viral gene delivery Reviewed

    Kawazu Takeshi, Kanzaki Hiroyuki, Uno Atsushi, Azuma Hideki, Nagasaki Takeshi

    BIOMEDICINE & PHARMACOTHERAPY   66 ( 7 )   519 - 524   2012.10( ISSN:0753-3322

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.biopha.2012.02.005

  • Protein recognition of hetero-/homoleptic ruthenium(II) tris(bipyridine)s for alpha-chymotrypsin and cytochrome c Reviewed

    Yamaguchi Yoshinobu, Kato Nobuo, Azuma Hideki, Nagasaki Takeshi, Ohkanda Junko

    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS   22 ( 6 )   2354 - 2358   2012.03( ISSN:0960-894X

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.bmcl.2011.12.087

  • Protein recognition of hetero-/homoleptic ruthenium(II) tris(bipyridine)s for α-chymotrypsin and cytochrome c

    Y. Yamaguchi, N. Kato, H. Azuma, T. Nagasaki, J. Ohkanda

    Bioorg. Med. Chem. Lett.   22   2354 - 2358   2012

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  • Tumor accumulation of ε-poly-lysines-based polyamines conjugated with boron clusters

    M. Umano, K. Uechi, T. Uriuda, S. Murayama, H. Azuma, A. Shinohara, Y. Liu, K. Ono, M. Kirihata, H. Yanagie, T. Nagasaki

    Appl. Radiat. Isot.   69   519 - 524   2012

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  • HVJ-E/importin-β hybrid vector for overcoming cytoplasmic and nuclear membranes as double barrier for non-viral gene delivery

    T. Kawazu, H. Kanzaki, A. Uno, H. Azuma, T. Nagasaki

    Biomed. Pharmacother.   66   519 - 524   2012

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  • Tumor accumulation of epsilon-poly-lysines-based polyamines conjugated with boron clusters Reviewed

    Umano Masayuki, Uechi Kazuhiro, Uriuda Takatoshi, Murayama Sayuri, Azuma Hideki, Shinohara Atsuko, Liu Young, Ono Koji, Kirihata Mitsunori, Yanagie Hironobu, Nagasaki Takeshi

    APPLIED RADIATION AND ISOTOPES   69 ( 12 )   1765 - 1767   2011.12( ISSN:0969-8043

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.apradiso.2011.02.048

  • Biological activity of water-soluble inclusion complexes of 1 '-acetoxychavicol acetate with cyclodextrins Reviewed

    Azuma Hideki, Aizawa Yui, Higashitani Nao, Tsumori Takashi, Kojima-Yuasa Akiko, Matsui-Yuasa Isao, Nagasaki Takeshi

    BIOORGANIC & MEDICINAL CHEMISTRY   19 ( 12 )   3855 - 3863   2011.06( ISSN:0968-0896

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.bmc.2011.04.038

  • Biological activity of water-soluble inclusion complexes of 1'-acetoxychavicol acetate with cyclodextrins

    H. Azuma, Y. Aizawa, N. Higashitani, T. Tsumori, A. Kojima-Yuasa, I. Matsui-Yuasa, T. Nagasaki

    Bioorg. Med. Chem.   19   855 - 3863   2011

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  • Preparation and antitumor activity of water-soluble inclusion complexes of cyclodextrins with 1'-Acetoxychavicol Acetate Reviewed

    Azuma Hideki, Aizawa Yui, HIgashitani Nao, Kojima Akiko, Nagasaki Takeshi

    Association of Research for Host-Guest and Supramolecular Chemistry, Abstracts of Papers: Host-Guest Chemistry Symposium   2011 ( 0 )   33 - 33   2011

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.14916/hgsupra.2011.0.33.0

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  • 1 '-Acetoxychavicol Acetate Enhances the Phase II Enzyme Activities via the Increase in Intranuclear Nrf2 Level and Cytosolic p21 Level Reviewed

    Yaku Keisuke, Matsui-Yuasa Isao, Azuma Hideki, Kojima-Yuasa Akiko

    AMERICAN JOURNAL OF CHINESE MEDICINE   39 ( 4 )   789 - 802   2011( ISSN:0192-415X

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1142/S0192415X11009196

  • 1'-Acetoxychavicol acetate enhances the phase II enzyme activities via the increase in intranuclear Nrf2 level and cytosolic p21 level

    K. Yaku, I. Matsui-Yuasa, H. Azuma, A. Kojima-Yuasa

    Am. J. Chin. Med.   39   789 - 802   2011

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  • Comparison of glutathione reductase activity and the intracellular glutathione reducing effects of 13 derivatives of 1 '-acetoxychavicol acetate in Ehrlich ascites tumor cells Reviewed

    Xu Shenghui, Kojima-Yuasa Akiko, Azuma Hideki, Kennedy David Opare, Konishi Yotaro, Matsui-Yuasa Isao

    CHEMICO-BIOLOGICAL INTERACTIONS   185 ( 3 )   235 - 240   2010.05( ISSN:0009-2797

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.cbi.2010.03.018

  • Enhanced internalization and endosomal escape of dual-functionalized poly(ethyleneimine)s polyplex with diphtheria toxin T and R domains Reviewed

    Kakimoto Shinji, Tanabe Toshizumi, Azuma Hideki, Nagasaki Takeshi

    BIOMEDICINE & PHARMACOTHERAPY   64 ( 4 )   296 - 301   2010.04( ISSN:0753-3322

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.biopha.2009.06.017

  • Structure-activity relationships of (1' S)-acetoxychavicol acetate for the decrease in intracellular glutathione level in Ehrlich ascites tumor cells Reviewed

    Matusi-Yuasa Isao, Xu Shenghui, Kojima-Yuasa Akiko, Azuma Hideki, Kennedy David Opare

    FASEB JOURNAL   24   2010.04( ISSN:0892-6638

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  • Comparison of glutathione reductase activity and the intracellular glutathione reducing effects of 13 derivatives of 1'-acetoxychavicol acetate in Ehrlich ascites tumor cells

    S. Xu, A. Kojima-Yuasa, H. Azuma, D. O. Kennedy, Y. Konishi, I. Matsui-Yuasa

    Chem. Biol. Interact.   185   235 - 240   2010

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  • Enhanced Internalization and Endosomal Escape of Dual-Functinalized Poly(ethylenimine)s Polyplex with Diphtheria toxin T and R Domains

    S. Kakimoto, T. Tanabe, H. Azuma, T. Nagasaki

    Biomed. Pharmacother.   64   296 - 301   2010

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  • (1\#8217;S)-Acetoxychavicol acetate and its enantiomer cause the inhibition of tumor cell growth via different mechanisms Reviewed

    Xu Shenghui, Kojima-Yuasa Akiko, Azuma Hideki, Matsui-Yuasa Isao

    CANCER RESEARCH   69   2009.05( ISSN:0008-5472

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  • The conjugation of diphtheria toxin T domain to poly(ethylenimine) based vectors for enhanced endosomal escape during gene transfection Reviewed

    Kakimoto Shinji, Hamada Tsutomu, Komatsu Yuuki, Takagi Masahiro, Tanabe Toshizumi, Azuma Hideki, Shinkai Seiji, Nagasaki Takeshi

    BIOMATERIALS   30 ( 3 )   402 - 408   2009.01( ISSN:0142-9612

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.biomaterials.2008.09.042

  • The conjugation of diphtheria toxin T domain to poly(ethylenimine) based vectors for enhanced endosomal escape during gene transfection

    S. Kakimoto, T. Hamada, Y. Komatsu, M. Takagi,T. Tanabe, H. Azuma, S. Shinkai, T. Nagasaki

    Biomaterials   30   402 - 408   2009

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  • Cytochrome c-binding "proteo-dendrimers" as a new type of apoptosis inhibitors working in HeLa cells system Reviewed

    Azuma Hideki, Yoshida Yuuka, Paul Dharam, Shinoda Satoshi, Tsukube Hiroshi, Nagasaki Takeshi

    Association of Research for Host-Guest and Supramolecular Chemistry, Abstracts of Papers: Host-Guest Chemistry Symposium   2009 ( 0 )   13 - 13   2009

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.14916/hgsupra.2009.0.13.0

    CiNii Article

  • Cytochrome c-binding "proteo-dendrimers" as new types of apoptosis inhibitors working in HeLa cell systems Reviewed

    Azuma Hideki, Yoshida Yuuka, Paul Dharam, Shinoda Satoshi, Tsukube Hiroshi, Nagasaki Takeshi

    ORGANIC & BIOMOLECULAR CHEMISTRY   7 ( 8 )   1700 - 1704   2009( ISSN:1477-0520

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1039/b900154a

  • Cytochrome c-binding "proteo-dendrimers" as new types of apoptosis inhibitors working in HeLa cell systems

    Y. Yoshida, D. Paul, S. Shinoda, H. Tsukube, T. Nagasaki

    Org. Biomol. Chem.   7   1700 - 1704   2009

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  • (1'S)-acetoxychavicol acetate and its enantiomer inhibit tumor cells proliferation via different mechanisms Reviewed

    Xu Shenghui, Kojima-Yuasa Akiko, Azuma Hideki, Huang Xuedan, Norikura Toshio, Kennedy David Opare, Matsui-Yuasa Isao

    CHEMICO-BIOLOGICAL INTERACTIONS   172 ( 3 )   216 - 223   2008.04( ISSN:0009-2797

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.cbi.2008.01.002

  • (1’S)-Acetoxychavicol Acetate and its Enantiomer Inhibit Tumor Cells Proliferation via Different Mechanisms

    S. Xu, A. Kojima-Yuasa, H. Azuma, X. Huang, T. Norikura, D. O. Kennedy, I. Matsui-Yuasa

    Chem. Biol. Interact.   172   216 - 223   2008

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  • (1'-S)- Acetoxychavicol Acetate and its Enantiomer Enhances the Cytotoxic Activity of Cisplatin in Ehrlich Ascites Tumor Cells Reviewed

    Xu Shenghui, Yuasa-Kojima Akiko, Azuma Hideki, Yuasa-Matsui Isao

    Osaka City University, Journal of human life science   7   13 - 20   2008( ISSN:13486926

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  • Short-chain 3-ketoceramides, strong apoptosis inducers against human leukemia HL-60 cells Reviewed

    Azuma Hideki, Ijichi So, Kataoka Mayuko, Masuda Akira, Izumi Takayuki, Yoshimoto Tetsuya, Tachibana Taro

    BIOORGANIC & MEDICINAL CHEMISTRY   15 ( 8 )   2860 - 2867   2007.04( ISSN:0968-0896

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.bmc.2007.02.008

  • Short-chain 3-Ketoceramides, strong apoptosis inducers against human leukemia HL-60 Cells

    S. Ijichi, M. Kataoka, A. Masuda, T. Izumi, T. Yoshimoto, T. Tachibana

    Bioorg. Med. Chem   15   2860 - 2867   2007

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    Publishing type:Research paper (scientific journal)  

  • Lipase-catalyzed preparation of optically active 1 '-acetoxychavicol acetates and their structure-activity relationships in apoptotic activity against human leukemia HL-60 cells Reviewed

    Azuma H, Miyasaka K, Yokotani T, Tachibana T, Kojima-Yuasa A, Matsui-Yuasa I, Ogino K

    BIOORGANIC & MEDICINAL CHEMISTRY   14 ( 6 )   1811 - 1818   2006.03( ISSN:0968-0896

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.bmc.2005.10.029

  • (3Z)-2-Acetylamino-3-octadecen-1-ol as A Potent Apoptotic Agent Against HL-60 Cells

    Hayato Niiro, Hideki Azuma, Sinsuke Tanago, Taro Tachibana, Kenji Ogino

    Bioorg. Med. Chem.   12   45 - 52   2004

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    Publishing type:Research paper (scientific journal)  

  • Total Syntheses of Symbioramide Derivatives from L-Serine and their Antileukemic Activities

    H. Azuma, R. Takao, H. Niiro, K. Shikata, S. Tamagaki

    The Journal of Organic Chemistry   68 ( 7 )   2790 - 2797   2003

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    Publishing type:Research paper (scientific journal)  

  • Synthesis and Potent Antileukemic Activities of N-Lactyl-sphingosine and N-Lactyl-dihydrosphingosine

    Journal of Medicinal Chemistry   46   3445&#8211;3447   2003

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    Publishing type:Research paper (scientific journal)  

  • Apoptotic Activities of C2-Ceramide and C2-Dihydroceramide Homologues Against HL-60 Cells

    Bioorganic and Medicinal Chemistry   11   2723&#8211;2728   2003

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    Publishing type:Research paper (scientific journal)  

  • Synthesis of Non-natural C2-Homo-Ceramide and its Apoptotic Activity against HL-60 Cells

    Bioorganic and Medicinal Chemistry Letters   13   613&#8211;616   2003

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    Publishing type:Research paper (scientific journal)  

  • Synthesis of Novel and Non-natural Ceramide Analogues Derived from L-glutamic Acid

    Tetrahedron   58   5803&#8211;5809   2002

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    Publishing type:Research paper (scientific journal)  

  • Stereospecific Total Syntheses of Sphingosine and Its Analogues from L-Serine

    Journal of Organic Chemistry   65   3538 - 3541   2000

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    Publishing type:Research paper (scientific journal)  

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Presentations

  • 糖鎖抗原用の糖セラミドLex-C12Lの合成 Domestic conference

    竹林尚志、東秀紀、長崎健

    第43回有機合成学会若手セミナー  2023.08 

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    Venue:京都工芸繊維大学  

  • 4-((E)-3-Hydroxyprop-1-enyl)phenyl acetate修飾ALAを基にした メラノーマ治療薬の開発 Domestic conference

    松枝蒼弥、東秀紀、長崎健

    第43回有機合成学会若手セミナー  2023.08  有機合成化学協会関西支部

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    Venue:京都工芸繊維大学  

  • Design and synthesis of new chiral derivatization agent for simultaneous analysis of D- and L-amino acids Domestic conference

    2023.03 

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    Presentation type:Poster presentation  

  • キラル誘導体化試薬の開発とD,L-アミノ酸一斉分析への応用 Domestic conference

    佐藤 俊, 佐々木 一謹, 東 秀紀

    新アミノ酸分析研究会 第12回学術講演会  2022.12  新アミノ酸分析研究会

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    Presentation type:Oral presentation (general)  

    Venue:大田区産業プラザ PiO  

  • Development of chiral derivatizing reagent: Application to simultaneous analysis of D,L-amino acids Domestic conference

    2022.09  Institute for Advanced Biosciences, Keio University

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    Presentation type:Poster presentation  

  • ガレクチン-3及びアシアロ糖タンパクレセプターをターゲットとしたラクトース提示型シクロデキストリンベシクルの作製 Domestic conference

    立石奈央, 東 秀紀, 長崎 健

    第18回 ホスト-ゲスト・超分子化学シンポジウム  2021.06 

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    Presentation type:Poster presentation  

  • コウジ酸アルドール付加体を用いた光延条件下における新規ホモカップリング反応 Domestic conference

    東 秀紀, 森島康仁, 中畔慶人, 加藤麗子, 長崎 健

    日本化学会第101春季年会  2021.03 

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    Presentation type:Oral presentation (general)  

  • Preparation and intracellular migration of self-assembled and folic-acid modified vesicles composed of anthraquinone-bearing cyclodextrin and 1’-acetoxychavicol acetate Domestic conference

    Hideki Azuma, Chisa Fukuda, Akiko Kojima, Takeshi Nagasaki

    The 45th Symposium on Biomolecular Science  2018.06 

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    Presentation type:Oral presentation (general)  

  • Application of self-assembled vesicles prepared from anthraquinone-modified cyclodextrins as carriers of 1’-acetoxychavicol acetate and presentation of folic acid on the surfaces Domestic conference

    Hideki Azuma, Chisa Fukuda, Takeshi Nagasaki

    The 98th CSJ Annual Meeting  2018.03 

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    Presentation type:Poster presentation  

  • Study on melanoma selective uptake of kojic acid using its fluorescent labeled analogues Domestic conference

    Yasuhito Morishima, Takuya Oofuji, Hideki Azuma, Takeshi Nagasaki

    The 47th Congress of Heterocyclic Chemistry  2017.10 

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    Presentation type:Poster presentation  

  • アントラキノン修飾シクロデキストリンへの葉酸レセプターをターゲットにした細胞選択性 の付与 Domestic conference

    東秀紀, 福田千紗, 長崎健

    第33回日本DDS学会学術集会  2017.07 

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    Presentation type:Poster presentation  

  • Lipase-catalyzed optical resolution of shikonin/alkannin Domestic conference

    Hideki AZUMA, kyosuke Enomoto, Toshio SUZUKI, Taizo TANIGUCHI, Takeshi NAGASAKI

    The Society of Physical Organic Chemistry, Japan  2017.06 

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    Presentation type:Poster presentation  

  • Preparation of self-assembled vesicles from anthraquinone-modified cyclodextrin/1’-acetoxychavicol acetate complexes and presentation of folic acids on the vesicle surfaces Domestic conference

    Chisa Fukuda, Hideki AZUMA, Takeshi NAGASAKI

    The Society of Physical Organic Chemistry, Japan  2017.06 

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    Presentation type:Poster presentation  

  • 1’―アセトキシチャビコールアセテート/シクロデキストリン複合体の抗炎症効果 Domestic conference

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    第33回 シクロデキストリンシンポジウム  2016.09 

  • アントラキノン修飾β-シクロデキストリンより調製した1'-acetoxychavicol acetateに対するキャリアとしての応用 Domestic conference

    -

    第33回シクロデキストリンシンポジウム  2016.09 

  • 1’-アセトキシチャビコールアセテート/シクロデキストリン複合体の抗炎症効果 Domestic conference

    -

    第14回ホスト・ゲスト化学シンポジウム  2016.06 

  • Preparation of the water-soluble inclusion complex of coumaryl alcohol derivative with 2-hydroxypropyl-beta-cyclodextrin and its enhancing effect on photodynamic therapy Domestic conference

    Host−Guest Chemistry Symposium 2016  2016.06 

  • アントラキノン修飾シクロデキストリンより調製した自己集積性ベシクルの 1’-acetoxychavicol acetate に対するキャリアとしての応用(阪市大 Domestic conference

    -

    第14回ホスト・ゲスト化学シンポジウム  2016.06 

  • Enhancing effect of coumaryl alcohol derivative on Photodynamic Therapy Domestic conference

    2016.03 

  • Anti-inflammatory effect of water-soluble inclusion complexes of 1'-acetoxychavicol acetate with cyclodextrins Domestic conference

    2015.06 

  • Enhancing effect of the metabolite of 1'-acetoxychavicol acetate (ACA) on photodynamic therapy Domestic conference

    2015.03 

  • Enhancing effect of the metabolite of 1'-acetoxychavicol acetate (ACA) on mitochondrial apoptosis Domestic conference

    The 93rd Annual Meeting of The Chemical Society of Japan  2014.03 

  • 玉造黒門越瓜に含まれる新規アルコール性肝障害抑制物質の同定 1'-Acetoxychavicol acetateのシクロデキストリンによる水溶化及び抗炎症効果に関する研究 Domestic conference

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    第33回有機合成若手セミナー  2013.08 

  • ミトコンドリア経由アポトーシスを制御する新規化合物の探索及び水溶化の検討 Domestic conference

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    第29回日本DDS学会学術集会  2013.07 

  • Anti-inflammation effect of water-soluble inclusion complexes of 1'-acetoxychavicol acetate with cyclodextrins Domestic conference

    The 93rd Annual Meeting of The Chemical Society of Japan  2013.03 

  • 低酸素細胞をターゲットとした新規シクロデキストリンキャリアの合成 アポトーシスを制御する新規化合物の探索 Domestic conference

    -

    第32回有機合成若手セミナー  2012.11 

  • Preparation and apoptogenic potency of Mcl-1 siRNA-encapsulated liposome containing short-chain 3-ketoceramide International conference

    The International Symposium on Nucleic Acid Chemistry  2011.11 

  • Mcl-1 siRNA を包埋したケトセラミドリポソームの作製及びアポトーシス誘導活性評価 Domestic conference

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    アンチセンス・遺伝子・デリバリー シンポジウム2011  2011.09 

  • 抗体作製におけるα-ガラクトシルセラミド類含有リポソームのアジュバント効果 Domestic conference

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    第5回バイオ関連化学シンポジウム  2011.09 

  • シクロデキストリンを用いた水溶性1’-Acetoxychavicol Acetate複合体の作製及び抗腫瘍効果に関する研究 Domestic conference

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    第7回ホスト・ゲスト化学シンポジウム  2011.05 

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Industrial Property Rights

  • 2-(2-オキソ-4-置換ピペラジニル)シクロアルキルカルバメート化合物又はその塩、当該化合物を用いる鏡像異性体の分析方法

    佐藤 俊, 佐々木 一謹, 東 秀紀

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    property_type:Patent 

    Application no:特願2021-103757 

  • 白血球活性化抑制剤

    竹村 茂一,岡 真優子,新川 寛二,新川 寛二,東 秀紀,南山 幸子

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    property_type:Patent 

    【課題】これまでの炎症抑制剤は、安全性や有効性の面で十分ではなかった。特に、慢性炎症に対して効果的な炎症抑制剤が求められていた。
    【解決手段】本発明は、S―アリルグルタチオン、S―アリルグルタチオン誘導体、及びそれらの塩からなる群から選ばれる一又は複数を含有する白血球活性化抑制剤である。また、本発明の白血球活性化抑制剤は、炎症性サイトカインの産出を抑制するものであってもよく、炎症反応を抑制するものであってもよい。

  • 水難溶性薬理活性物質の薬理活性を維持しながら水溶性を付与する方法

    鈴木 利雄、植田 秀昭、長崎 健,東 秀紀、小島 明子、湯浅 勲

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    property_type:Patent 

    【課題】実用上十分な水溶性を有するとともに薬理活性が維持された水難溶性薬理活性物質複合体を提供する。
    【解決手段】水難溶性薬理活性物質と、β-1,3結合に対するβ-1,6結合の分岐度が50~100%であるβ-1,3-1,6-D-グルカンとの複合体。

  • 抗肥満剤

    湯浅 勲、小島 明子、東 秀紀

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    property_type:Patent 

    【課題】抗肥満作用に優れ、しかも、安全性の高い成分を有効成分とする抗肥満剤を提供する。
    【解決手段】1’-アセトキシチャビコールアセテート、1-アセトキシ-1-(2,4-ジアセトキシフェニル)-2-プロペン、及び1-アセトキシ-1-(3,4-ジアセトキシフェニル)-2-プロペン及びその誘導体と4-((E)-3-ヒドロキシ-1-プロペニル)フェニルアセテート、及び2-アセトキシ-4-((E)-3-ヒドロキシ-1-プロペニル)フェニルアセテート、及び3-アセトキシ-4-((E)-3-ヒドロキシ-1-プロペニル)フェニルアセテート及びその誘導体を有効成分とする抗肥満剤。

  • コラーゲン産生促進剤

    小島 明子、東 秀紀

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    property_type:Patent 

    【課題】コラーゲン産生を促進させる作用に優れ、合成も簡便であり、かつ水溶液中でも安定な産生促進剤の提供。
    【解決手段】一般式(1)
    (式中、R1、R2、R4、R5は、水素、水酸基、アルキル基、又は-O-C(=O)R6を示す。R6はアルキル基を示す。R3は、水素、アルキル基又は-C(=O)R7を示す。R7はアルキル基を示す。)で表される化合物を有効成分とするコラーゲン産生促進剤。

  • シトクロムc捕捉型アポトーシス抑制剤

    長崎 健、東 秀紀、築部 浩、篠田哲史

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    property_type:Patent 

    Patent/Registration no:4767295 

    【課題】これまで知られていない作用機序に基づく新しいアポトーシス抑制剤を提供する。
    【解決手段】アポトーシス時にミトコンドリアから漏出するシトクロムcをポルフィリンカルボン酸にデンドリティックペンタキスグルタミン酸ペプチドを付加して作製したポルフィリンのアニオン性デンドリマー化合物で捕捉することによりアポトーシスを抑制するアポトーシス抑制剤。

  • コラーゲン産生促進剤

    湯浅 勲、小島 明子、東 秀紀

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    property_type:Patent 

    Patent/Registration no:5207227 

    【課題】コラーゲン産生促進剤乃至組成物の提供。
    【解決手段】1-アセトキシ-1-(2,4-ジアセトキシフェニル)-2-プロペン(1-Acetoxy-1-(2,4-diacetoxyphenyl)-2-propene、以下、2,4-ACAとも称する)、1-アセトキシ-1-(3,4-ジアセトキシフェニル)-2-プロペン(1-Acetoxy-1-(3,4-diacetoxyphenyl)-2-propene、以下、3,4-ACAとも称する)、及び1-アセトキシ-1-(4-アセトキシフェニル)-2 ヘプチンで表される化合物を有効成分とするコラーゲン産生促進剤。並びに、当該コラーゲン促進剤を含有してなる化粧用組成物、細胞培養用組成物及び創傷治癒用医薬組成物。

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Outline of collaborative research (seeds)

  • Synthese of the bioactive compounds of sphingolipids

    2001.1-

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    Application fields / methods etc:For the significance of sphingolipids for skin function, we will contribute for product development in the cosmetic industry to elucidate the difference of activities by the structural features.

    Sphingolipuds are abundantly located in plasma membranes and composed of sphingosine, a fatty acid and a polar head group. We synthesize these analogs and investigate the bioactivities of them.

Other subsidies, etc.

  • コウジ酸修飾ホウ素クラスターを用いた中性子捕捉療法のメラノーマへの適用を目指した基礎研究

    未設定  2011.07

  • チャビコールフラグメントを基にした新規コラーゲン産生促進剤の開発

    未設定  2010.10

Outline of education staff

  • 化学バイオ工学科の教育では、生物や生命システムを理解するだけでなく、化学や物理学、情報処理などの広い範囲の工学的な知識をもち、社会や産業に貢献できる新しい技術やものを生み出せる人材の育成が目的となる。従って、生物学のみならず、化学、物理学にまたがる広範な教育が必要とされ、講座全体で効率の良い教育方法を考えていかなければならない。現在、学部では分析化学Ⅱ及び情報バイオ演習を担当しており、分析化学Ⅱでは様々な分析機器から得られるデータの読み取り方について講義し、情報バイオ演習では今日の研究者に必須のパソコンを用いた情報処理能力の向上を目指した教育を行っている。これらの講義・演習により、基礎知識やプレゼンテーション能力に加え、得られたデータから次になすべき実験を的確に考えるといった研究遂行能力の高い人材を育成したいと考えている。

Charge of on-campus class subject

  • Exercises in Bioinformatics

    2023   Weekly class   Undergraduate

  • Analytical chemistry II

    2023   Weekly class   Undergraduate

  • 情報バイオ演習

    2022   Weekly class   Undergraduate

  • 分析化学Ⅱ

    2021   Weekly class   Undergraduate

  • バイオ工学実験Ⅰ

    2021   Weekly class   Undergraduate

  • 化学バイオ工学演習A

    2021   Weekly class   Undergraduate

  • 情報バイオ演習

    2021   Weekly class   Undergraduate

  • 分析化学Ⅱ

    2020     Undergraduate

  • バイオ工学実験Ⅰ

    2020     Undergraduate

  • 化学バイオ工学演習A

    2020     Undergraduate

  • 情報バイオ演習

    2020     Undergraduate

  • Analytical Chemistry II

    2019     Undergraduate

  • バイオ工学実験Ⅰ

    2019     Undergraduate

  • Exercises in Applied Chemistry and Bioengineering A

    2019     Undergraduate

  • IT Exercises in Bioengineering

    2019     Undergraduate

  • Analytical Chemistry II

    2018     Undergraduate

  • バイオ工学実験Ⅰ

    2018     Undergraduate

  • IT Exercises in Bioengineering

    2018     Undergraduate

  • Exercises in Applied Chemistry and Bioengineering A

    2018     Undergraduate

  • Exercises in Applied Chemistry and Bioengineering A

    2017     Undergraduate

  • バイオ工学実験Ⅰ

    2017     Undergraduate

  • Analytical Chemistry II

    2017     Undergraduate

  • IT Exercises in Bioengineering

    2017     Undergraduate

  • バイオ工学実験Ⅰ

    2016     Undergraduate

  • 分析化学Ⅱ

    2016     Undergraduate

  • 情報バイオ演習

    2016     Undergraduate

  • 化学バイオ工学演習A

    2016     Undergraduate

  • 技術と生命(第9回&第10回)

    2015     Undergraduate

  • 分析化学Ⅱ

    2015     Undergraduate

  • 情報バイオ演習

    2015     Undergraduate

  • バイオ工学実験Ⅰ

    2015     Undergraduate

  • 化学バイオ工学演習Ⅱ

    2015     Undergraduate

  • 情報バイオ演習

    2014     Undergraduate

  • 分析化学Ⅱ

    2014     Undergraduate

  • バイオ工学実験Ⅰ

    2014     Undergraduate

  • 情報バイオ演習

    2013     Undergraduate

  • 分析化学Ⅱ

    2013     Undergraduate

  • バイオ工学実験Ⅰ

    2013     Undergraduate

  • バイオ工学実験Ⅰ

    2012     Undergraduate

  • 分析化学Ⅱ

    2012     Undergraduate

  • 情報バイオ演習

    2012     Undergraduate

  • バイオ工学実験Ⅰ

    2011     Undergraduate

  • 情報バイオ演習

    2011     Undergraduate

  • 分析化学Ⅱ

    2011     Undergraduate

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Faculty development activities

  • 工学部FD集会  2022

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    2022年9月2日にオンライン開催された工学部FD集会に参加した。

  • FD活動への貢献  2011

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    2011年度工学部FD集会「授業のこつとひけつ」に参加。

Number of instructed thesis, researches

  • 2022

    Number of instructed the graduation thesis:Number of graduation thesis reviews:2

    [Number of instructed the Master's Program] (previous term):[Number of instructed the Master's Program] (letter term):0

    [Number of master's thesis reviews] (chief):[Number of master's thesis reviews] (vice-chief):0

    [Number of doctoral thesis reviews] (chief):[Number of doctoral thesis reviews] (vice-chief):0

  • 2021

    Number of instructed the graduation thesis:Number of graduation thesis reviews:2

    [Number of instructed the Master's Program] (previous term):

    [Number of master's thesis reviews] (chief):[Number of master's thesis reviews] (vice-chief):0

    [Number of doctoral thesis reviews] (chief):[Number of doctoral thesis reviews] (vice-chief):0

  • 2020

    Number of instructed the graduation thesis:Number of graduation thesis reviews:3

    [Number of instructed the Master's Program] (previous term):[Number of instructed the Master's Program] (letter term):0

    [Number of master's thesis reviews] (chief):[Number of master's thesis reviews] (vice-chief):0

    [Number of doctoral thesis reviews] (chief):[Number of doctoral thesis reviews] (vice-chief):0

  • 2011

    Number of instructed the graduation thesis:Number of graduation thesis reviews:3

    [Number of instructed the Master's Program] (previous term):[Number of instructed the Master's Program] (letter term):0

    [Number of master's thesis reviews] (chief):[Number of master's thesis reviews] (vice-chief):0

    [Number of doctoral thesis reviews] (chief):[Number of doctoral thesis reviews] (vice-chief):0

Academic Activities

  • 論文査読

    Role(s): Peer review

    2022.04 - 2023.03

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    Type:Peer review 

Original item / Special report (Management administration)

  • 2022

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    Original item:危険物保安監督者(工学研究科危険物倉庫)

  • 2021

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    Original item:危険物保安監督者(工学研究科危険物倉庫)

Other

  • Job Career

    2007.04 - Now

  • Job Career

    2002.04 - 2007.03

  • Job Career

    1998.10 - 2002.03