Updated on 2024/03/23

写真a

 
WATANABE Toshio
 
Organization
Graduate School of Medicine Department of Clinical Medical Science Professor
School of Medicine Department of Medical Science
Title
Professor
Affiliation
Institute of Medicine

Position

  • Graduate School of Medicine Department of Clinical Medical Science 

    Professor  2022.04 - Now

  • School of Medicine Department of Medical Science 

    Professor  2022.04 - Now

Degree

  • 医学博士 ( Osaka City University )

Research Areas

  • Life Science / Gastroenterology

  • Life Science / Medical management and medical sociology

Research Interests

  • カプセル内視鏡

  • 自然免疫

  • 腸内細菌

  • 小腸

  • ピロリ菌

  • 潰瘍

  • プロスタグランジン

  • ビッグデータ解析

  • バイオマーカー開発

Research subject summary

  • 食道炎、胃炎、ならびに大腸炎は慢性の消化管炎症であり、それぞれの臓器の癌の発生にも関連している。癌ならびに消化管の炎症の病態生理を基礎的ならびに臨床的に研究している。特に最近では薬剤性傷害などの小腸疾患の病態解明と新たな治療法の開発の研究を精力的に行なっている。

  • 人間ドック受診データベースを用いた各種疾患のリスク因子解析などの疫学研究およびバイオバンク試料を用いたバイオマーカー開発を行う

Research Career

  • Roles of prostaglandins and cyclooxygenases in the pathogenesis of gastrointestinal diseases

    prostaglandin, cyclooxygenase, cytokine  Individual

    1997.04 

  • 消化管細菌叢のメタゲノム解析

    2015.01 - Now 

  • 小腸疾患に対する基礎的、臨床的アプローチ

    2004.01 - Now 

  • H. pylori関連疾患の基礎・臨床的研究

    2000.01 - Now 

Professional Memberships

  • American College of Gastroenterology

      Overseas

  • American Gastroenterological Association,

      Overseas

  • 日本消化器免疫学会

      Domestic

  • 日本消化管学会

      Domestic

  • 日本潰瘍学会

      Domestic

  • 日本消化器内視鏡学会

      Domestic

  • 日本消化器病学会

      Domestic

  • 日本内科学会

      Domestic

  • 日本人間ドック学会

      Domestic

  • 日本消化器がん検診学会

      Domestic

  • 日本がん予防学会

      Domestic

  • 日本微小循環学会

  • 日本ヘリコバクター学会

  • 日本総合健診医学会

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Committee Memberships (off-campus)

  • 総合内科専門医   日本内科学会  

  • 試験問題作成委員会委員長   日本ヘリコバクター学会  

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    理事、ピロリ菌感染症認定医、

  • カリキュラム検討部会   日本消化管学会  

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    指導医、専門医、評議員

  • 指導医、専門医、評議員   日本消化器内視鏡学会  

  • 指導医、専門医、評議員   日本消化器病学会  

  • 学会あり方委員会委員長   日本微小循環学会  

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    理事

  • Fellow   American College of Gastroenterology  

  • Fellow   American Gastroenterological Association  

  • 評議員   日本消化器免疫学会  

  • 理事   日本潰瘍学会  

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Awards

  • 大阪市立大学医学部長賞奨励賞

    2016.03  

  • 大阪市立大学医学部長賞特別奨励賞

    2014.03  

  • IGICS, Young Investigators Award

    2008  

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    Country:Japan

  • 日本ヘリコバクター学会上原H. pylori優秀賞

    2001  

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    Country:Japan

  • 大阪市医学会市長賞

    1998  

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    Country:Japan

  • 日本実験潰瘍学会奨励賞

    1996  

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    Country:Japan

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Education

  • Osaka City University     Graduated/Completed

    1983.04 - 1989.03

  • Osaka City University   Doctor's Course   Graduated/Completed

    - 1996

Papers

  • Prevalence and associated metabolic factors of nonalcoholic fatty liver disease in the general population from 2014 to 2018 in Japan: A large-scale multicenter retrospective study. Reviewed

    Fujii H, Suzuki Y, Sawada K, Tatsuta M, Maeshiro T, Tobita H, Tsutsumi T, Akahane T, Hasebe C, Kawanaka M, Kessoku T, Eguchi Y, Syokita H, Nakajima A, Kamada T, Yoshiji H, Kawaguchi T, Sakugawa H, Morishita A, Masaki T, Ohmura T, Watanabe T, Kawada N, Yoda Y, Enomoto N, Ono M, Fuyama K, Okada K, Nishimoto N, Ito YM, Kamada Y, Takahashi H, Sumida Y, Japan Study Group of Nonalcoholic Fatty Liver Disease (JSG-NAFLD)

    Hepatology research : the official journal of the Japan Society of Hepatology   53 ( 11 )   1059 - 1072   2023.11( ISSN:1386-6346

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/hepr.13947

    PubMed

  • Prevalence and associated metabolic factors of nonalcoholic fatty liver disease in the general population from 2014 to 2018 in Japan: A large-scale multicenter retrospective study(タイトル和訳中) Reviewed

    Fujii Hideki, Suzuki Yuichiro, Sawada Koji, Tatsuta Miwa, Maeshiro Tatsuji, Tobita Hiroshi, Tsutsumi Tsubasa, Akahane Takemi, Hasebe Chitomi, Kawanaka Miwa, Kessoku Takaomi, Eguchi Yuichiro, Syokita Hayashi, Nakajima Atsushi, Kamada Tomoari, Yoshiji Hitoshi, Kawaguchi Takumi, Sakugawa Hiroshi, Morishita Asahiro, Masaki Tsutomu, Ohmura Takumi, Watanabe Toshio, Kawada Norifumi, Yoda Yoshioki, Enomoto Nobuyuki, Ono Masafumi, Fuyama Kanako, Okada Kazufumi, Nishimoto Naoki, Ito Yoichi M., Kamada Yoshihiro, Takahashi Hirokazu, Sumida Yoshio

    Hepatology Research   53 ( 11 )   1059 - 1072   2023.11( ISSN:1386-6346

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    Publishing type:Research paper (scientific journal)  

  • Association of plasma xanthine oxidoreductase activity with vascular endothelial function independent of serum uric acid level: MedCity21 health examination registry. Reviewed

    Kurajoh M, Fukumoto S, Akari S, Murase T, Nakamura T, Ihara Y, Imai T, Nagata Y, Morioka T, Mori K, Imanishi Y, Watanabe T, Emoto M

    International journal of cardiology. Heart & vasculature   48   101264   2023.10( ISSN:2352-9067

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.ijcha.2023.101264

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  • Chest radiography as a biomarker of ageing: artificial intelligence-based, multi-institutional model development and validation in Japan. Reviewed

    Mitsuyama Y, Matsumoto T, Tatekawa H, Walston SL, Kimura T, Yamamoto A, Watanabe T, Miki Y, Ueda D

    The lancet. Healthy longevity   4 ( 9 )   e478 - e486   2023.09

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/S2666-7568(23)00133-2

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  • Upper gastrointestinal endoscopic findings in functional constipation and irritable bowel syndrome diagnosed using the Rome IV criteria: a cross-sectional survey during a medical check-up in Japan. Reviewed

    Otani K, Watanabe T, Takahashi K, Nadatani Y, Ominami M, Fukunaga S, Hosomi S, Kamata N, Tanaka F, Nagami Y, Taira K, Kimura T, Fukumoto S, Fujiwara Y

    BMC gastroenterology   23 ( 1 )   140   2023.05

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s12876-023-02784-6

    PubMed

  • Esophageal mast cells may be associated with the perception of symptoms in patients with eosinophilic esophagitis. Reviewed

    Kanamori A, Tanaka F, Takashima S, Sawada A, Ominami M, Nadatani Y, Fukunaga S, Otani K, Hosomi S, Kamata N, Nagami Y, Taira K, Watanabe T, Fujiwara Y

    Esophagus : official journal of the Japan Esophageal Society   20 ( 2 )   333 - 341   2023.04( ISSN:1612-9059

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s10388-022-00967-w

    PubMed

  • 食道の肥満細胞は好酸球性食道炎患者の症状自覚に関連する(Esophageal mast cells may be associated with the perception of symptoms in patients with eosinophilic esophagitis) Reviewed

    Kanamori Atsushi, Tanaka Fumio, Takashima Shingo, Sawada Akinari, Ominami Masaki, Nadatani Yuji, Fukunaga Shusei, Otani Koji, Hosomi Shuhei, Kamata Noriko, Nagami Yasuaki, Taira Koichi, Watanabe Toshio, Fujiwara Yasuhiro

    Esophagus   20 ( 2 )   333 - 341   2023.04( ISSN:1612-9059

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    Publishing type:Research paper (scientific journal)  

    無症候性の食道好酸球浸潤(aEE)患者28名と、症候性の好酸球性食道炎(EoE)患者58名の食道生検標本の免疫蛍光染色により肥満細胞関連分子量を調べ、症状の自覚と肥満細胞量との関係について検討した。臨床的および内視鏡的特徴、および好酸球ピーク値について群間で有意差はなかった。EoE群の肥満細胞トリプターゼ陽性面積はaEE群と比べて有意に大きかった。EoE群のPAR-2陽性細胞数はaEE群と比べて有意に多かった。EoE群のVPAC-1陽性細胞数はaEE群と比べて有意に多かった。PAR-2陽性細胞数とVPAC-1陽性細胞数は正相関した。肥満細胞トリプターゼ陽性面積はPAR-2およびVPAC-1陽性細胞数と正相関した。以上の結果から、食道の肥満細胞とその受容体PAR-2およびVPAC-1はEoE患者の症状自覚に関与すると考えられた。

  • Long-term rebleeding rate and predictive factors of rebleeding after capsule endoscopy in patients with obscure GI bleeding. Reviewed

    Otani K, Shimada S, Watanabe T, Nadatani Y, Higashimori A, Ominami M, Fukunaga S, Hosomi S, Kamata N, Tanaka F, Nagami Y, Taira K, Fujiwara Y

    Gastrointestinal endoscopy   96 ( 6 )   956 - 969.e3   2022.12( ISSN:0016-5107

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.gie.2022.07.012

    PubMed

  • An extra 1-cm margin during endoscopic submucosal dissection can control subsquamous tumor extension of esophagogastric junction adenocarcinoma. Reviewed

    Manabe T, Nagami Y, Tanoue K, Sakai T, Maruyama H, Ominami M, Fukunaga S, Otani K, Hosomi S, Tanaka F, Taira K, Watanabe T, Fujiawaral Y

    Endoscopy international open   10 ( 11 )   E1501 - E1507   2022.11( ISSN:2364-3722

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1055/a-1936-9073

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  • Gastrointestinal IgG4 Deposition Is a New Histopathological Feature of Eosinophilic Gastroenteritis. Reviewed

    Kosaka S, Tanaka F, Nakata A, Nadatani Y, Fukunaga S, Otani K, Hosomi S, Kamata N, Nagami Y, Taira K, Watanabe T, Fujiwara Y

    Digestive diseases and sciences   67 ( 8 )   3639 - 3648   2022.08( ISSN:0163-2116

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s10620-021-07244-3

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  • Evaluation of long-term survival in patients with severe comorbidities after endoscopic submucosal dissection for esophageal squamous cell carcinoma. Reviewed

    Hirano S, Nagami Y, Yamamura M, Tanoue K, Sakai T, Maruyama H, Ominami M, Nadatani Y, Fukunaga S, Otani K, Hosomi S, Tanaka F, Kamata N, Taira K, Shiba M, Watanabe T, Fujiwara Y

    Surgical endoscopy   36 ( 7 )   5011 - 5022   2022.07( ISSN:0930-2794

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00464-021-08859-3

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  • Lustrous White Erosions Surrounded by an Erythematous Mucosa: A Novel Endoscopic Finding of Gastric Lesions in Patients with Wilson Disease. Reviewed

    Kitagawa D, Ominami M, Taira K, Tanoue K, Higashimori A, Maruyama H, Itani S, Nishida Y, Nadatani Y, Fukunaga S, Otani K, Hosomi S, Tanaka F, Nagami Y, Kamata N, Kuwae Y, Watanabe T, Ohsawa M, Fujiwara Y, F-study Group

    Internal medicine (Tokyo, Japan)   61 ( 12 )   1835 - 1841   2022.06( ISSN:0918-2918

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.2169/internalmedicine.8076-21

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  • 紅斑性粘膜に取り囲まれた光沢のある白色びらん Wilson病患者における胃病変の新規内視鏡所見(Lustrous White Erosions Surrounded by an Erythematous Mucosa: A Novel Endoscopic Finding of Gastric Lesions in Patients with Wilson Disease) Reviewed

    Kitagawa Daiki, Ominami Masaki, Taira Koichi, Tanoue Kojiro, Higashimori Akira, Maruyama Hirotsugu, Itani Shigehiro, Nishida Yu, Nadatani Yuji, Fukunaga Shusei, Otani Koji, Hosomi Shuhei, Tanaka Fumio, Nagami Yasuaki, Kamata Noriko, Kuwae Yuko, Watanabe Toshio, Ohsawa Masahiko, Fujiwara Yasuhiro

    Internal Medicine   61 ( 12 )   1835 - 1841   2022.06( ISSN:0918-2918

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    Publishing type:Research paper (scientific journal)  

    症例1は20歳男性で、18歳時にWilson病と診断されていた。心窩部痛を認め、汎血球減少症、肝胆汁酵素の軽度上昇、セルロプラスミンと銅の血清レベル低値、尿中銅排泄量増加が判明した。内視鏡検査では、胃に紅斑に囲まれた白色びらんが認められた。8週のエソメプラゾール治療により、心窩部痛と白色びらんが改善した。症例2は27歳男性で、5歳時にWilson病と診断されていた。心窩部痛、悪心、嘔吐を認め、肝胆汁酵素の軽度上昇、セルロプラスミンと銅の血清レベル低値、尿中銅排泄量増加が判明した。内視鏡検査では、胃に紅斑性粘膜に囲まれた線形白色ビランが認められた。エソメプラゾール治療を開始後、症状が改善した。症例3は42歳男性で、30歳時にWilson病と診断されていた。上腹部症状はなかったが、汎血球減少症、肝胆汁酵素の軽度上昇、プロトロンビン活性低下、セルロプラスミンと銅の血清レベル低下、尿中銅排泄量増加が判明した。内視鏡検査では、胃の紅斑性粘膜上に斑状の白色びらんが認められた。3症例ともに、病変の生検ではオルセイン陽性組織が認められ、銅沈着が示唆された。

  • Pirfenidone prevents esophageal stricture by inhibiting nucleotide binding oligomerization domain like receptor protein 3 inflammasome activation. Reviewed

    Hirano S, Higashimori A, Nagami Y, Nadatani Y, Tanigawa T, Ominami M, Fukunaga S, Otani K, Hosomi S, Tanaka F, Kamata N, Taira K, Watanabe T, Fujiwara Y

    Journal of gastroenterology and hepatology   37 ( 6 )   1096 - 1106   2022.06( ISSN:0815-9319

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/jgh.15861

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  • Angle of covered self-expandable metallic stents after placement is a risk factor for recurrent biliary obstruction. Reviewed

    Tanoue K, Maruyama H, Ishikawa-Kakiya Y, Kinoshita Y, Hayashi K, Yamamura M, Ominami M, Nadatani Y, Fukunaga S, Otani K, Hosomi S, Tanaka F, Kamata N, Nagami Y, Taira K, Watanabe T, Fujiwara Y

    World journal of hepatology   14 ( 5 )   992 - 1005   2022.05( ISSN:1948-5182

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.4254/wjh.v14.i5.992

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  • Lifestyle changes during the coronavirus disease 2019 pandemic impact metabolic dysfunction-associated fatty liver disease. Reviewed

    Fujii H, Nakamura N, Fukumoto S, Kimura T, Nakano A, Nadatani Y, Tauchi Y, Nishii Y, Takashima S, Kamada Y, Watanabe T, Kawada N

    Liver international : official journal of the International Association for the Study of the Liver   42 ( 5 )   995 - 1004   2022.05( ISSN:1478-3223

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/liv.15158

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  • A questionnaire-based survey on the etiopathogenesis of chronic constipation during a medical check-up in Japan. Reviewed

    Otani K, Watanabe T, Takahashi K, Ominami M, Nadatani Y, Fukunaga S, Hosomi S, Kamata N, Tanaka F, Nagami Y, Taira K, Kimura T, Fukumoto S, Fujiwara Y

    Journal of clinical biochemistry and nutrition   70 ( 2 )   205 - 211   2022.03( ISSN:0912-0009

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.3164/jcbn.21-87

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  • Pyogenic Spondylitis Caused by Staphylococcus schleiferi in a Patient with Crohn's Disease. Reviewed

    Fujimoto K, Hosomi S, Nakata R, Sugita N, Nishida Y, Fukunaga S, Nadatani Y, Otani K, Tanaka F, Kamata N, Nagami Y, Taira K, Watanabe T, Fujiwara Y

    Internal medicine (Tokyo, Japan)   61 ( 4 )   577 - 580   2022.02( ISSN:0918-2918

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.2169/internalmedicine.7368-21

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  • クローン病患者におけるStaphylococcus schleiferiにより引き起こされた化膿性脊椎炎(Pyogenic Spondylitis Caused by Staphylococcus schleiferi in a Patient with Crohn's Disease) Reviewed

    Fujimoto Koji, Hosomi Shuhei, Nakata Rieko, Sugita Naoko, Nishida Yu, Fukunaga Shusei, Nadatani Yuji, Otani Koji, Tanaka Fumio, Kamata Noriko, Nagami Yasuaki, Taira Koichi, Watanabe Toshio, Fujiwara Yasuhiro

    Internal Medicine   61 ( 4 )   577 - 580   2022.02( ISSN:0918-2918

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    Publishing type:Research paper (scientific journal)  

    症例は42歳男性で、24年前にクローン病と診断されていた。複数回の腸切除術後に短腸症候群を発症し、9年前から中心静脈(CV)ポートによる在宅中心静脈栄養を行っていた。8年前からアダリムマブとアザチオプリンが投与され、臨床的寛解であった。1週前から持続する頸部痛と高熱により入院し、左手筋の軽度筋力低下を認めた。血液検査では、白血球数の増加とC反応性タンパクの上昇を認めたが、脳・胸部・腹部のCTで感染の徴候は示されなかった。細菌血流感染の疑いで、メロペネムとバンコマイシンの静脈内投与を開始した。入院3日目、入院時に採取した血液培養でコアグラーゼ陰性菌とグラム陽性菌が検出された。カテーテル関連血流感染(CRBSI)と診断し、CVポートを抜去した。血液培養とCVポート先端からStaphylococcus schleiferiが検出された。入院4日目のMRIでC6およびC7椎体の異常造影が判明し、CRBSIによる血行性化膿性脊椎炎と診断した。

  • Interferon-α exerts proinflammatory properties in experimental radiation-induced esophagitis: Possible involvement of plasmacytoid dendritic cells. Reviewed

    Kitamura H, Tanigawa T, Kuzumoto T, Nadatani Y, Otani K, Fukunaga S, Hosomi S, Tanaka F, Kamata N, Nagami Y, Taira K, Uematsu S, Watanabe T, Fujiwara Y

    Life sciences   289   120215   2022.01( ISSN:0024-3205

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.lfs.2021.120215

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  • Prevalence and risk factor for chronic diarrhea in participants of a Japanese medical checkup. Reviewed

    Matsumoto Y, Nadatani Y, Otani K, Higashimori A, Ominami M, Fukunaga S, Hosomi S, Kamata N, Kimura T, Fukumoto S, Tanaka F, Taira K, Nagami Y, Watanabe T, Fujiwara Y

    JGH open : an open access journal of gastroenterology and hepatology   6 ( 1 )   69 - 75   2022.01

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/jgh3.12704

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  • A Questionnaire-Based Survey on the Impact of the COVID-19 Pandemic on Gastrointestinal Endoscopy in Asia. Reviewed

    Otani K, Watanabe T, Higashimori A, Suzuki H, Kamiya T, Shiotani A, Sugimoto M, Nagahara A, Fukudo S, Motoya S, Yamaguchi S, Zhu Q, Chan FKL, Hahm KB, Tablante MC, Prachayakul V, Abdullah M, Ang TL, Murakami K, International Gastrointestinal Consensus Symposium Study Group

    Digestion   103 ( 1 )   7 - 21   2022( ISSN:0012-2823

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1159/000520287

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  • Ovariectomy-Induced Dysbiosis May Have a Minor Effect on Bone in Mice. Reviewed

    Kosaka S, Nadatani Y, Higashimori A, Otani K, Fujimoto K, Nagata Y, Ominami M, Fukunaga S, Hosomi S, Kamata N, Tanaka F, Nagami Y, Taira K, Imoto S, Uematsu S, Watanabe T, Fujiwara Y

    Microorganisms   9 ( 12 )   2021.12( ISSN:2076-2607

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.3390/microorganisms9122563

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  • 人間ドック受診を契機に発見された好酸球性食道炎の臨床像および内視鏡所見の検討 Reviewed

    高嶋 信吾, 灘谷 祐二, 西居 由布子, 田内 幸枝, 大谷 恒史, 田中 史生, 藤井 英樹, 中野 朱美, 木村 達郎, 福本 真也, 藤原 靖弘, 渡邉 俊雄

    人間ドック   36 ( 4 )   545 - 551   2021.12( ISSN:1880-1021

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    Publishing type:Research paper (scientific journal)  

    目的:人間ドック受診者における好酸球性食道(Eosinophilic esophagitis:EoE)の臨床像を明らかにすることを目的とした。方法:2015年4月〜2020年10月の人間ドック受診者延べ33,877人を対象としEoEと診断したEoE群と、年齢・性別を合わせて無作為に抽出した対照群で検討を行った。標準的な健診項目と上部消化管内視鏡所見について単変量解析し、p値が0.1未満の因子に対して多変量解析した。またEoE群でEoEに特徴的な内視鏡所見についての検討も行った。結果:20,145例の解析を行いEoEの発見率は0.47%であった。単変量解析ではEoE群に飲酒歴・つかえ感や胸やけ症状・アレルギー歴があることが有意に多く、内視鏡所見と他の健診項目については有意差を認めなかった。多変量解析の結果、飲酒歴・つかえ感や胸やけ症状・アレルギー歴があること・内視鏡所見でバレット食道がないことがEoEの独立した危険因子であることが明らかになった。EoEに特徴的な内視鏡所見のなかでは縦走溝が93%と最も多く認められた。結論:アレルギー疾患の既往、つかえ感や胸やけ症状、飲酒歴があり、内視鏡所見でバレット食道を認めない受診者には、EoEである可能性を考え特徴的な内視鏡所見を探したうえで積極的に食道粘膜の好酸球数を評価することが人間ドックでのEoEの発見率向上のために重要であると考えられた。(著者抄録)

  • 舌下免疫療法によって誘導された好酸球性食道炎の症例集積研究 中止か吐出か(A case series of sublingual immunotherapy-induced eosinophilic esophagitis: stop or spit) Reviewed

    Fujiwara Yasuhiro, Tanaka Fumio, Sawada Akinari, Nadatani Yuji, Nagami Yasuaki, Taira Koichi, Nakamura Naohiro, Watanabe Toshio, Ohsawa Masahiko, Sakamoto Hirokazu

    Clinical Journal of Gastroenterology   14 ( 6 )   1607 - 1611   2021.12( ISSN:1865-7257

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    アレルギー性鼻炎に対する舌下免疫療法(SLIT)施行中に好酸球性食道炎(EoE)を発症した6例(男女各3例、平均年齢45.7歳)を経験した。症状としては、嚥下困難、胸やけ、胸骨後不快感が認められた。内視鏡検査では典型的なEoEの所見が認められ、生検で有意な好酸球浸潤が確認された。SLITの中止、ないしは吐出を行うことで症状は軽快し、内視鏡的および組織学的寛解が得られた。SLITによりアレルゲンが食道管腔内に侵入することでEoEが誘導されることが示された。また、SLITの際の吐出が、SLIT誘導性EoEの治療法の一つとなる可能性が示唆された。

  • A case series of sublingual immunotherapy-induced eosinophilic esophagitis: stop or spit. Reviewed

    Fujiwara Y, Tanaka F, Sawada A, Nadatani Y, Nagami Y, Taira K, Nakamura N, Watanabe T, Ohsawa M, Sakamoto H

    Clinical journal of gastroenterology   14 ( 6 )   1607 - 1611   2021.12

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    DOI: 10.1007/s12328-021-01520-5

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  • Chronic constipation is negatively associated with colonic diverticula. Reviewed

    Higashimori A, Nakatani M, Jinnai K, Kin D, Maeda N, Nakamura Y, Hashimoto A, Morimoto K, Sasaki E, Fukuda T, Watanabe T, Fujiwara Y

    Scandinavian journal of gastroenterology   56 ( 11 )   1264 - 1270   2021.11( ISSN:0036-5521

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    DOI: 10.1080/00365521.2021.1961307

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  • Heartburn, Functional Dyspepsia, Anxiety/Depression, and Sleep Disturbances Are Associated With Clinically Significant Belching. Reviewed

    Fujiwara Y, Okuyama M, Nagami Y, Taira K, Ishizu H, Takaishi O, Sato H, Watanabe T

    Journal of neurogastroenterology and motility   27 ( 4 )   581 - 587   2021.10( ISSN:2093-0879

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    DOI: 10.5056/jnm20225

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  • A 25 mg rectal dose of diclofenac for prevention of post-ERCP pancreatitis in elderly patients. Reviewed

    Maeda N, Higashimori A, Nakatani M, Mizuno Y, Nakamura Y, Ikeda D, Maruyama H, Morimoto K, Fukuda T, Watanabe T, Fujiwara Y

    Scandinavian journal of gastroenterology   56 ( 9 )   1109 - 1116   2021.09( ISSN:0036-5521

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    DOI: 10.1080/00365521.2021.1946134

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  • Reply to the letter by Ouyang et al. regarding our manuscript "Long-term persistence of gastric dysbiosis after eradication of Helicobacter pylori in patients who underwent endoscopic submucosal dissection for early gastric cancer". Reviewed

    Watanabe T, Nadatani Y, Fujiwara Y

    Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association   24 ( 4 )   980 - 981   2021.07( ISSN:1436-3291

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    DOI: 10.1007/s10120-021-01198-1

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  • 早期胃癌のために内視鏡的粘膜下層剥離術を受けた患者におけるHelicobacter pylori除菌後の胃内ディスバイオシスの長期的持続(Long-term persistence of gastric dysbiosis after eradication of Helicobacter pylori in patients who underwent endoscopic submucosal dissection for early gastric cancer) Reviewed

    Watanabe Toshio, Nadatani Yuji, Suda Wataru, Higashimori Akira, Otani Koji, Fukunaga Shusei, Hosomi Shuhei, Tanaka Fumio, Nagami Yasuaki, Taira Koichi, Tanigawa Tetsuya, Nakatsu Geicho, Hattori Masahira, Fujiwara Yasuhiro

    Gastric Cancer   24 ( 3 )   710 - 720   2021.05( ISSN:1436-3291

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    早期胃癌のために内視鏡的粘膜下層剥離術を受けた患者のペアサンプル(Helicobacter pylori除菌前と除菌後)について、胃粘膜におけるH.pyloriの除菌に伴う微生物叢の変化について検討した。内視鏡的粘膜下層剥離術の対象となった早期胃癌患者でH.pylori感染者19例(年齢中央値67歳)を登録した。H.pylori陰性の患者10例を対照とした。H.pylori陽性患者では、Blautia、Ralstonia、Faecalibacterium、Methylobacterium、Megamonasなどの複数の属が除去されており、細菌の豊富さと均一性が低かった。H.pylori除菌後の追跡期間の中央値13ヵ月において、細菌の多様性が部分的に回復したが、H.pylori除菌患者の細菌は対照群に比べて多様性が低く、前述の5属の存在率も低かった。また、H.pylori除菌により細菌組成が変化したが、対照群と同様の組成ではなかった。さらに、胃内の微生物群は、H.pylori陰性、除菌前、除菌後の三つのグループに分類することができた。以上より、胃癌を発症したことのある患者では、H.pylori除菌後もディスバイオシスが長く続く可能性があった。また、そのような患者では、H.pyloriの除菌後の原発性および異時性胃癌の発症にディスバイオシスが関与している可能性があった。

  • 好酸球性食道炎と無症候性食道好酸球症は似た免疫組織学的プロファイルを呈す(Eosinophilic esophagitis and asymptomatic esophageal eosinophilia display similar immunohistological profiles) Reviewed

    Kitamura Hiroyuki, Tanaka Fumio, Nadatani Yuji, Otani Koji, Hosomi Shuhei, Kamata Noriko, Taira Koichi, Nagami Yasuaki, Tanigawa Tetsuya, Fukumoto Shinya, Watanabe Toshio, Kawada Norifumi, Fujiwara Yasuhiro

    Journal of Clinical Biochemistry and Nutrition   68 ( 3 )   246 - 252   2021.05( ISSN:0912-0009

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    好酸球性食道炎(EoE)患者43名(男性28名、平均46.7歳)および無症候性食道好酸球症(aEE)患者18名(男性10名、平均47.1歳)の食道生検試料を用いて、免疫組織化学染色により免疫関連組織バイオマーカーを定量した。BMIを除き患者群間に臨床的、内視鏡および組織学的な有意差はなかった。免疫関連組織バイオマーカーである主要塩基性タンパク質、好酸球由来ニューロトキシン、エオタキシン-3および免疫グロブリンG4についてEoEとaEEとの間に有意差はなかった。EoEとaEEは同様の免疫組織学的プロファイルを示すことから、両者は共通する病態メカニズムを有する近縁の疾患と考えられた。本研究の結果から、aEE患者でも病理組織学的に食道の炎症を有することが示唆された。

  • 多種アレルゲン特異的IgEの診断的アッセイにより示された感作パターンに基づいた、食道好酸球増多症症例の分類(Classification of patients with esophageal eosinophilia by patterns of sensitization revealed by a diagnostic assay for multiple allergen-specific IgEs) Reviewed

    Nakata Akinobu, Tanaka Fumio, Nadatani Yuji, Fukunaga Shusei, Otani Koji, Hosomi Shuhei, Kamata Noriko, Taira Koichi, Nagami Yasuaki, Watanabe Toshio, Fujiwara Yasuhiro

    Journal of Gastroenterology   56 ( 5 )   422 - 433   2021.05( ISSN:0944-1174

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    食道好酸球増多症(EE)患者における、IgE媒介性アレルギー感作パターンを検討することを目的とした。多種アレルゲン特異的IgE診断パネルによる評価を受けたEE症例を検討対象とした。クラスター解析により統計学的に有意な3群を同定し、アレルゲンを室外、室内、植物および動物アレルゲンと定義した。第1群(62例)は花粉およびハウスダスト以外の殆どのアレルゲンに対して軽度感作されていた。第2群(30例)は屋外および植物アレルゲンに高度感作されていた。第3群(15例)は殆どのアレルゲンに高度感作されており、特に室内および動物アレルゲンに対する反応が高度であった。第1、2、3群における嚥下障害の頻度は、それぞれ35.5%、46.7%、73.3%であった(P=0.028)。好酸球性食道炎(EoE)内視鏡的参照スコア(EREFS)は、それぞれ3.0、6.0、8.0であった(P<0.001)。また第3群では、第1群と比較して嚥下障害の頻度が有意に高く(35.5%対73.3%、P=0.030)、EREFSスコアに関して、輪状溝(0.3対0.9、P=0.003)および狭窄(0.0対0.13、P=0.011)の値が高かった。IgE媒介性アレルギー感作パターンはEE患者の臨床像と関連しており、IgEパネルは患者の特徴を明らかにするために有用であると考えられた。

  • Vonoprazan shows efficacy similar to that of proton pump inhibitors with respect to symptomatic, endoscopic, and histological responses in patients with eosinophilic esophagitis Reviewed

    Kuzumoto Takuya, Tanaka Fumio, Sawada Akinari, Nadatani Yuji, Otani Koji, Hosomi Shuhei, Kamata Noriko, Taira Koichi, Nagami Yasuaki, Tanigawa Tetsuya, Watanabe Toshio, Fujiwara Yasuhiro

    ESOPHAGUS   18 ( 2 )   372 - 379   2021.04( ISSN:1612-9059

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    DOI: 10.1007/s10388-020-00783-0

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  • 好酸球性食道炎患者において、ボノプラザンは症状、内視鏡的および組織学的効果の点で、プロトンポンプ阻害薬と同様の効果を示す(Vonoprazan shows efficacy similar to that of proton pump inhibitors with respect to symptomatic, endoscopic, and histological responses in patients with eosinophilic esophagitis) Reviewed

    Kuzumoto Takuya, Tanaka Fumio, Sawada Akinari, Nadatani Yuji, Otani Koji, Hosomi Shuhei, Kamata Noriko, Taira Koichi, Nagami Yasuaki, Tanigawa Tetsuya, Watanabe Toshio, Fujiwara Yasuhiro

    Esophagus   18 ( 2 )   372 - 379   2021.04( ISSN:1612-9059

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    118例の好酸球性食道炎(EoE)患者に対して、ラベプラゾール10mg(RPZ10、22例、男性68.2%、平均年齢41.2±7.9歳)、ラベプラゾール20mg(RPZ20、34例、男性64.7%、平均年齢45.2±11.2歳)、エスメプラゾール20mg(EPZ20、25例、男性52%、平均年齢46.7±11.2歳)、ボノプラザン20mg(VPZ20、33例、男性72.7%、平均年齢45.4±8.6歳)を投与した。自覚症状は、完全消失、部分消失、無変化の3群に分け、内視鏡的効果は、薬剤投与後の内視鏡的参照スコア(EREFS)で評価した。組織学的反応は、食道生検標本中の好酸球数で、完全寛解(好酸球/高倍率視野(eos/HPF)が0/1)および寛解(<15 eos/HPF)に分けた。群間で治療開始前の臨床的特徴、内視鏡的所見、組織学的所見に差は認められなかった。臨床症状の完全消失はRPZ10群が54.5%、RPZ20群が64.7%、EPZ20群が72.0%、VPZ20群が75.7%であった。治療効果に関しては群間で有意差を認めなかった。同様に、内視鏡的および組織学的完全寛解率も群間で差は認められなかった。ボノプラザンは好酸球性食道炎患者において、プロトンポンプ阻害薬と同様の効果を示した。

  • A case of nivolumab-induced cervical lymphadenopathy in a patient with gastric cancer. Reviewed

    Taira K, Kimura A, Nakata A, Nadatani Y, Fukunaga S, Otani K, Hosomi S, Tanaka F, Kamata N, Nagami Y, Watanabe T, Fujiwara Y

    Journal of gastrointestinal oncology   12 ( 2 )   880 - 884   2021.04( ISSN:2078-6891

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    DOI: 10.21037/jgo-20-315

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  • Comparison of the Diagnostic Efficiency of Radial- and Convex-Arrayed Echoendoscopes for Indirect Findings of Pancreatic Cancer: A Retrospective Comparative Study Using Propensity Score Method Reviewed

    Ishikawa-Kakiya Yuki, Maruyama Hirotsugu, Yamamoto Kei, Yamamura Masafumi, Tanoue Kojiro, Higashimori Akira, Ominami Masaki, Nadatani Yuji, Fukunaga Shusei, Otani Koji, Hosomi Shuhei, Tanaka Fumio, Kamata Noriko, Nagami Yasuaki, Taira Koichi, Shiba Masatsugu, Watanabe Toshio, Fujiwara Yasuhiro

    CANCERS   13 ( 6 )   2021.03

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    DOI: 10.3390/cancers13061217

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  • Role of nucleotide binding oligomerization domain-like receptor protein 3 inflammasome in stress-induced gastric injury Reviewed

    Higashimori Akira, Watanabe Toshio, Nadatani Yuji, Nakata Akinobu, Otani Koji, Hosomi Shuhei, Tanaka Fumio, Kamata Noriko, Taira Koichi, Nagami Yasuaki, Tanigawa Tetsuya, Fujiwara Yasuhiro

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   36 ( 3 )   740 - 750   2021.03( ISSN:0815-9319

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    DOI: 10.1111/jgh.15257

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  • Classification of patients with esophageal eosinophilia by patterns of sensitization revealed by a diagnostic assay for multiple allergen-specific IgEs Reviewed

    Nakata Akinobu, Tanaka Fumio, Nadatani Yuji, Fukunaga Shusei, Otani Koji, Hosomi Shuhei, Kamata Noriko, Taira Koichi, Nagami Yasuaki, Watanabe Toshio, Fujiwara Yasuhiro

    JOURNAL OF GASTROENTEROLOGY   2021.02( ISSN:0944-1174

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    DOI: 10.1007/s00535-021-01766-3

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  • Prevalence and risk factors of functional constipation in the Rome IV criteria during a medical check-up in Japan Reviewed

    Otani Koji, Watanabe Toshio, Takahashi Kanae, Nadatani Yuji, Fukunaga Shusei, Hosomi Shuhei, Tanaka Fumio, Kamata Noriko, Taira Koichi, Nagami Yasuaki, Kimura Tatsuo, Fukumoto Shinya, Kawada Norifumi, Fujiwara Yasuhiro

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   2021.02( ISSN:0815-9319

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    DOI: 10.1111/jgh.15436

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  • Ring-Shaped Thread Counter Traction-Assisted Endoscopic Retrograde Cholangiopancreatography of a Huge Periampullary Diverticula Reviewed

    Ishikawa-Kakiya Yuki, Maruyama Hirotsugu, Yamamoto Kei, Yamamura Masafumi, Tanoue Kojiro, Ominami Masaki, Fukunaga Shusei, Taira Koichi, Nagami Yasuaki, Watanabe Toshio, Fujiwara Yasuhiro

    AMERICAN JOURNAL OF GASTROENTEROLOGY   116 ( 1 )   12 - 12   2021.01( ISSN:0002-9270

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    DOI: 10.14309/ajg.0000000000000842

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  • Rebamipide ameliorates indomethacin-induced small intestinal damage and proton pump inhibitor-induced exacerbation of this damage by modulation of small intestinal microbiota. Reviewed

    Tanigawa T, Watanabe T, Higashimori A, Shimada S, Kitamura H, Kuzumoto T, Nadatani Y, Otani K, Fukunaga S, Hosomi S, Tanaka F, Kamata N, Nagami Y, Taira K, Shiba M, Suda W, Hattori M, Fujiwara Y

    PloS one   16 ( 1 )   e0245995   2021

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    DOI: 10.1371/journal.pone.0245995

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  • A mask-based infection control method for screening endoscopy may prevent SARS-CoV-2 transmission and relieve staff anxiety. Reviewed

    Nadatani Y, Higashimori A, Takashima S, Maruyama H, Otani K, Fukunaga S, Hosomi S, Tanaka F, Fujii H, Nakano A, Taira K, Kamata N, Nagami Y, Kimura T, Fukumoto S, Watanabe T, Kawada N, Fujiwara Y

    2021 ( ISSN:2050-3121

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    Publishing type:Research paper (scientific journal)   International / domestic magazine:International journal  

    DOI: 10.1177/20503121211047060

  • The impact of cytochrome P450 3A genetic polymorphisms on tacrolimus pharmacokinetics in ulcerative colitis patients. Reviewed

    Furuse M, Hosomi S, Nishida Y, Itani S, Nadatani Y, Fukunaga S, Otani K, Tanaka F, Nagami Y, Taira K, Kamata N, Watanabe T, Watanabe K, Fujiwara Y

    PloS one   16 ( 4 )   e0250597   2021

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    DOI: 10.1371/journal.pone.0250597

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  • Protective role of resolvin D1, a pro-resolving lipid mediator, in nonsteroidal anti-inflammatory drug-induced small intestinal damage. Reviewed

    Kuzumoto T, Tanigawa T, Higashimori A, Kitamura H, Nadatani Y, Otani K, Fukunaga S, Hosomi S, Tanaka F, Kamata N, Nagami Y, Taira K, Watanabe T, Fujiwara Y

    PloS one   16 ( 5 )   e0250862   2021

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    DOI: 10.1371/journal.pone.0250862

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  • Impact of the Lockdown Due to the COVID-19 Pandemic on Patients With Inflammatory Bowel Disease. Reviewed

    Nishida Y, Hosomi S, Fujimoto K, Nakata R, Sugita N, Itani S, Nadatani Y, Fukunaga S, Otani K, Tanaka F, Nagami Y, Taira K, Kamata N, Watanabe T, Ohfuji S, Fujiwara Y

    Frontiers in medicine   8   649759   2021( ISSN:2296-858X

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    DOI: 10.3389/fmed.2021.649759

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  • Questionnaire-Based Survey on Epidemiology of Functional Gastrointestinal Disorders and Current Status of Gastrointestinal Motility Testing in Asian Countries. Reviewed

    Kamiya T, Osaga S, Kubota E, Fukudo S, Motoya S, Murakami K, Nagahara A, Shiotani A, Sugimoto M, Suzuki H, Watanabe T, Yamaguchi S, Chan FKL, Hahm KB, Fock KM, Zhu Q, International Gastroenterology Consensus Symposium Study Group.

    Digestion   102 ( 1 )   73 - 89   2020.12( ISSN:0012-2823

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    DOI: 10.1159/000513292

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  • A Rare Case of Clival Metastasis in a Patient with Gastric Cancer(和訳中) Reviewed

    Yoshikawa-Kimura Akie, Taira Koichi, Katanosaka Yuki, Nakata Akinobu, Nadatani Yuji, Fukunaga Shusei, Otani Koji, Hosomi Shuhei, Tanaka Fumio, Kamata Noriko, Nagami Yasuaki, Watanabe Toshio, Fujiwara Yasuhiro

    (一社)日本内科学会 Internal Medicine   59 ( 24 )   3161 - 3164   2020.12( ISSN:0918-2918

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  • Endoscopic findings of gastric lesions in patients with eosinophilic gastrointestinal disorders Reviewed

    Fujiwara Yasuhiro, Tanoue Kojiro, Higashimori Akira, Nishida Yu, Maruyama Masatsugu, Itani Shigehiro, Ominami Masaki, Nadatani Yuji, Fukunaga Shusei, Otani Koji, Hosomi Shuhei, Tanaka Fumio, Kamata Noriko, Nagami Yasuaki, Taira Koichi, Machida Hirohisa, Tanigawa Tetsuya, Watanabe Toshio, Ohsawa Masahiko

    ENDOSCOPY INTERNATIONAL OPEN   08 ( 12 )   E1817 - E1825   2020.12( ISSN:2364-3722

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    DOI: 10.1055/a-1268-7312

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  • The usefulness of serial pancreatic juice aspiration cytological examination for pancreatic cancer not diagnosed by EUS-FNAB Reviewed

    Ishikawa-Kakiya Yuki, Maruyama Hirotsugu, Kinoshita Yosuke, Hayashi Kappei, Yamamura Masafumi, Tanoue Kojiro, Nagami Yasuaki, Tanigawa Tetsuya, Watanabe Toshio, Fujiwara Yasuhiro

    CLINICAL JOURNAL OF GASTROENTEROLOGY   13 ( 6 )   1367 - 1372   2020.12( ISSN:1865-7257

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    DOI: 10.1007/s12328-020-01167-8

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  • The usefulness of serial pancreatic juice aspiration cytological examination for pancreatic cancer not diagnosed by EUS-FNAB(和訳中) Reviewed

    Ishikawa-Kakiya Yuki, Maruyama Hirotsugu, Kinoshita Yosuke, Hayashi Kappei, Yamamura Masafumi, Tanoue Kojiro, Nagami Yasuaki, Tanigawa Tetsuya, Watanabe Toshio, Fujiwara Yasuhiro

    シュプリンガー・ジャパン(株) Clinical Journal of Gastroenterology   13 ( 6 )   1367 - 1372   2020.12( ISSN:1865-7257

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  • Gastrointestinal endoscopic practice during COVID-19 pandemic: a multi-institutional survey. Reviewed

    Maruyama H, Hosomi S, Nebiki H, Fukuda T, Nakagawa K, Okazaki H, Yamagami H, Hara J, Tanigawa T, Machida H, Aomatsu K, Watanabe Y, Sato H, Uno H, Takaishi O, Nomura T, Ochi M, Oshitani N, Adachi K, Higashimori A, Ominami M, Nadatani Y, Fukunaga S, Otani K, Tanaka F, Kamata N, Nagami Y, Taira K, Watanabe T, Fujiwara Y

    Romanian journal of internal medicine = Revue roumaine de medecine interne   2020.11( ISSN:1220-4749

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    DOI: 10.2478/rjim-2020-0038

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  • Effects of Colchicine on NSAID-Induced Severe Small Intestinal Damage: A Pilot Study Reviewed

    Otani Koji, Watanabe Toshio, Higashimori Akira, Nadatani Yuji, Nagami Yasuaki, Taira Koichi, Inui Kentaro, Fujiwara Yasuhiro

    DIGESTION   1 - 6   2020.11( ISSN:0012-2823

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    DOI: 10.1159/000511255

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  • Long-term persistence of gastric dysbiosis after eradication of Helicobacter pylori in patients who underwent endoscopic submucosal dissection for early gastric cancer Reviewed

    Watanabe Toshio, Nadatani Yuji, Suda Wataru, Higashimori Akira, Otani Koji, Fukunaga Shusei, Hosomi Shuhei, Tanaka Fumio, Nagami Yasuaki, Taira Koichi, Tanigawa Tetsuya, Nakatsu Geicho, Hattori Masahira, Fujiwara Yasuhiro

    GASTRIC CANCER   2020.11( ISSN:1436-3291

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    DOI: 10.1007/s10120-020-01141-w

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  • Utility of Kyoto Classification of Gastritis in subjects with a high-negative titer of anti-<i>Helicobacter pylori</i> antibody during a medical check-up. Reviewed

    Otani K, Watanabe T, Kosaka S, Matsumoto Y, Nakata A, Nadatani Y, Fukunaga S, Hosomi S, Tanaka F, Kamata N, Taira K, Nagami Y, Tanigawa T, Kimura T, Fukumoto S, Kawada N, Fujiwara Y

    一般社団法人 日本酸化ストレス学会 Journal of clinical biochemistry and nutrition   67 ( 3 )   317 - 322   2020.11( ISSN:0912-0009

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    <p>Subjects with a high-negative titer (3–9.9 U/ml) of serum anti-<i>Helicobacter pylori</i> (<i>H. pylori</i>) antibody represent a heterogeneous group of currently <i>H. pylori</i>-infected, <i>H. pylori</i>-uninfected, and previously <i>H. pylori</i>-infected cases. We investigated the characteristics of subjects with a high-negative titer during a medical check-up and the utility of <i>H. pylori</i> infection score, the sum of scores of endoscopic findings based on the Kyoto Classification of Gastritis, for diagnosing <i>H. pylori</i> infection. Subjects with <sup>13</sup>C-urea breath test-positive or <i>H. pylori</i> stool antigen test-positive were diagnosed as currently <i>H. pylori</i>-infected. Although around half of subjects with a high-negative titer were after eradication therapy (48.6%), currently <i>H. pylori</i>-infected were considerably confirmed (11.7%). <i>H. pylori</i> infection score showed a high value of area under the receiver operating characteristic curve [0.92; 95% confidence interval (CI), 0.84–1.00] with the most suitable cut-off value of 1.0 (sensitivity: 0.92; specificity: 0.90). Multivariate logistic regression analysis revealed that <i>H. pylori</i> infection score was an independent factor associated with increased prevalence of <i>H. pylori</i> infection (odds ratio, 9.53; 95% CI, 2.64–34.40; <i>p</i><0.001). Currently <i>H. pylori</i>-infected subjects were considerably included among the subjects with a high-negative titer, and the Kyoto Classification of Gastritis was useful to predict current <i>H. pylori</i> infection.</p>

    DOI: 10.3164/jcbn.20-21

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  • Utility of Kyoto Classification of Gastritis in subjects with a high-negative titer of anti-Helicobacter pylori antibody during a medical check-up(和訳中) Reviewed

    Otani Koji, Watanabe Toshio, Kosaka Satoshi, Matsumoto Yuji, Nakata Akinobu, Nadatani Yuji, Fukunaga Shusei, Hosomi Shuhei, Tanaka Fumio, Kamata Noriko, Taira Koichi, Nagami Yasuaki, Tanigawa Tetsuya, Kimura Tatsuo, Fukumoto Shinya, Kawada Norifumi, Fujiwara Yasuhiro

    (一社)日本酸化ストレス学会 Journal of Clinical Biochemistry and Nutrition   67 ( 3 )   317 - 322   2020.11( ISSN:0912-0009

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  • Novel prognostic biomarkers of pouchitis after ileal pouch-anal anastomosis for ulcerative colitis: Neutrophil-to-lymphocyte ratio Reviewed

    Nishida Yu, Hosomi Shuhei, Yamagami Hirokazu, Fujimoto Koji, Nakata Rieko, Itani Shigehiro, Nadatani Yuji, Fukunaga Shusei, Otani Koji, Tanaka Fumio, Nagami Yasuaki, Taira Koichi, Kamata Noriko, Watanabe Toshio, Iseki Yasuhito, Fukuoka Tatsunari, Shibutani Masatsune, Nagahara Hisashi, Ohfuji Satoko, Fujiwara Yasuhiro

    PLOS ONE   15 ( 10 )   e0241322   2020.10( ISSN:1932-6203

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    DOI: 10.1371/journal.pone.0241322

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  • Safety of Endoscopic Mucosal Resection Using a Bipolar Snare for Superficial Nonampullary Duodenal Epithelial Tumors and the Predictive Factors of Piecemeal Resection. Reviewed

    Yamamura M, Nagami Y, Sakai T, Maruyama H, Ominami M, Fukunaga S, Otani K, Hosomi S, Tanaka F, Taira K, Yamagami H, Tanigawa T, Watanabe T, Fujiwara Y

    Digestion   1 - 9   2020.10( ISSN:0012-2823

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    DOI: 10.1159/000510601

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  • Repeated Endoscopic Submucosal Dissection for Esophageal Neoplasia Located Close to a Previous Endoscopic Submucosal Dissection Scar Reviewed

    Nagami Yasuaki, Ominami Masaki, Sakai Taishi, Maruyama Hirotsugu, Fukunaga Shusei, Otani Koji, Hosomi Shuhei, Tanaka Fumio, Taira Koichi, Kamata Noriko, Tanigawa Tetsuya, Shiba Masatsugu, Watanabe Toshio, Fujiwara Yasuhiro

    CLINICAL AND TRANSLATIONAL GASTROENTEROLOGY   11   2020.08

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  • Repeated Endoscopic Submucosal Dissection for Esophageal Neoplasia Located Close to a Previous Endoscopic Submucosal Dissection Scar. Reviewed

    Nagami Y, Ominami M, Sakai T, Maruyama H, Fukunaga S, Otani K, Hosomi S, Tanaka F, Taira K, Kamata N, Tanigawa T, Shiba M, Watanabe T, Fujiwara Y

    Clinical and translational gastroenterology   11 ( 8 )   e00226   2020.08

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    DOI: 10.14309/ctg.0000000000000226

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  • The effect of intervention by an antimicrobial stewardship team on anaerobic bacteremia Reviewed

    Kuwabara Gaku, Yukawa Satomi, Yamada Koichi, Imoto Waki, Yamairi Kazushi, Shibata Wataru, Yoshii Naoko, Watanabe Tetsuya, Asai Kazuhisa, Niki Makoto, Nakaie Kiyotaka, Okada Yasuyo, Fujita Akiko, Kaneko Yukihiro, Kawaguchi Tomoya, Kakeya Hiroshi

    ANAEROBE   64   2020.08( ISSN:1075-9964

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    DOI: 10.1016/j.anaerobe.2020.102214

  • Predictive factors for difficult endoscopic submucosal dissection for esophageal neoplasia including failure of en bloc resection or perforation Reviewed

    Nagami Yasuaki, Ominami Masaki, Sakai Taishi, Maruyama Hirotsugu, Fukunaga Shusei, Otani Koji, Hosomi Shuhei, Tanaka Fumio, Kamata Noriko, Taira Koichi, Tanigawa Tetsuya, Shiba Masatsugu, Watanabe Toshio, Fujiwara Yasuhiro

    SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES   2020.07( ISSN:0930-2794

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    DOI: 10.1007/s00464-020-07777-0

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  • Proton pump inhibitors enhance intestinal permeability via dysbiosis of gut microbiota under stressed conditions in mice Reviewed

    Takashima Shingo, Tanaka Fumio, Kawaguchi Yunoske, Usui Yuki, Fujimoto Kosuke, Nadatani Yuji, Otani Koji, Hosomi Shuhei, Nagami Yasuaki, Kamata Noriko, Taira Koichi, Tanigawa Tetsuya, Watanabe Toshio, Imoto Seiya, Uematsu Satoshi, Fujiwara Yasuhiro

    NEUROGASTROENTEROLOGY AND MOTILITY   32 ( 7 )   e13841   2020.07( ISSN:1350-1925

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    DOI: 10.1111/nmo.13841

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  • AGE-SPECIFIC RISK FACTORS OF INADEQUATE BOWEL PREPARATION FOR COLONOSCOPY: A PROSPECTIVE QUESTIONNAIRE-BASED OBSERVATIONAL STUDY Reviewed

    Higashimori Akira, Natsumi Maeda, Nakatani Masami, Nakamura Yoshihiro, Hashimoto Atsushi, Morimoto Kenichi, Fukuda Takashi, Watanabe Toshio, Fujiwara Yasuhiro

    GASTROINTESTINAL ENDOSCOPY   91 ( 6 )   AB555 - AB555   2020.06( ISSN:0016-5107

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  • LONG-TERM SURVIVAL OF PATIENTS WITH SEVERE COMORBIDITIES WHO RECEIVED ENDOSCOPIC SUBMUCOSAL DISSECTION FOR ESOPHAGEAL SQUAMOUS CELL CARCINOMA: A COMPARATIVE PROPENSITY SCORE ANALYSIS Reviewed

    Hirano Shinji, Nagami Yasuaki, Ominami Masaki, Yamamoto Kei, Manabe Taku, Kakiya Yuki, Tanoue Kojiro, Hayashi Kappei, Yamamura Masafumi, Sakai Taishi, Maruyama Hirotsugu, Fukunaga Shusei, Nadatani Yuji, Otani Koji, Hosomi Shuhei, Tanaka Fumio, Kamata Noriko, Taira Koichi, Tanigawa Tetsuya, Watanabe Toshio, Fujiwara Yasuhiro

    GASTROINTESTINAL ENDOSCOPY   91 ( 6 )   AB147 - AB147   2020.06( ISSN:0016-5107

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  • INCREASED INCIDENCE OF ELECTROCOAGULATION SYNDROME AFTER COROLECTAL ENDOSCOPIC SUBMUCOSAL DISSECTION IN ELDERLY PATIENTS: A RETROSPECTIVE STUDY Reviewed

    Fukunaga Shusei, Nagami Yasuaki, Yamamoto Kei, Manabe Taku, Kakiya Yuki, Tanoue Kojiro, Hayashi Kappei, Yamamura Masafumi, Maruyama Hirotsugu, Ominami Masaki, Nadatani Yuji, Otani Koji, Tanaka Fumio, Taira Koichi, Kamata Noriko, Tanigawa Tetsuya, Shiba Masatsugu, Watanabe Toshio, Fujiwara Yasuhiro

    GASTROINTESTINAL ENDOSCOPY   91 ( 6 )   AB492 - AB492   2020.06( ISSN:0016-5107

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  • HEPARIN BRIDGING THERAPY IS ASSOCIATED WITH DELAYED BLEEDING AFTER ENDOSCOPIC TREATMENT FOR COMMON BILE DUCT STONE IN PATIENTS TREATED WITH ORAL ANTITHROMBOTIC THERAPY Reviewed

    Hayashi Kappei, Maruyama Hirotsugu, Yamamoto Kei, Manabe Taku, Kimura Akie, Kakiya Yuki, Hirano Shinji, Tanoue Kojiro, Yamamura Masafumi, Ominami Masaki, Fukunaga Shusei, Nadatani Yuji, Otani Koji, Hosomi Shuhei, Tanaka Fumio, Kamata Noriko, Taira Koichi, Nagami Yasuaki, Tanigawa Tetsuya, Watanabe Toshio, Fujiwara Yasuhiro

    GASTROINTESTINAL ENDOSCOPY   91 ( 6 )   AB368 - AB369   2020.06( ISSN:0016-5107

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  • EFFECT OF COLCHICINE TREATMENT ON SEVERE NSAID-INDUCED SMALL INTESTINAL DAMAGE: A PILOT STUDY Reviewed

    Otani Koji, Watanabe Toshio, Nadatani Yuji, Fukunaga Shusei, Hosomi Shuhei, Tanaka Fumio, Kamata Noriko, Taira Koichi, Nagami Yasuaki, Tanigawa Tetsuya, Fujiwara Yasuhiro

    GASTROINTESTINAL ENDOSCOPY   91 ( 6 )   AB613 - AB614   2020.06( ISSN:0016-5107

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  • RISK FACTOR OF RECURRENT BILIARY OBSTRUCTION OF COVERED SELF-EXPANDABLE METALLIC STENT FOR UNRESECTABLE DISTAL MALIGNANT BILIARY STRICTURE Reviewed

    Tanoue Kojiro, Maruyama Hirotsugu, Yamamoto Kei, Manabe Taku, Kakiya Yuki, Hayashi Kappei, Yamamura Masafumi, Ominami Masaki, Fukunaga Shusei, Nadatani Yuji, Otani Koji, Tanaka Fumio, Taira Koichi, Kamata Noriko, Nagami Yasuaki, Tanigawa Tetsuya, Watanabe Toshio, Fujiwara Yasuhiro

    GASTROINTESTINAL ENDOSCOPY   91 ( 6 )   AB344 - AB345   2020.06( ISSN:0016-5107

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  • THE EFFECT OF PIRFENIDONE FOR ESOPHAGEAL STRICTURE AFTER CIRCUMFEREENTIAL ESOPHAGEAL ENDOSCOPIC SUBMUCOSAL DISSECTION IN A PORCINE MODEL Reviewed

    Hirano Shinji, Nagami Yasuaki, Sakai Taishi, Kakiya Yuki, Tanoue Kojiro, Hayashi Kappei, Sawada Akinari, Maruyama Hirotsugu, Ominami Masaki, Fukunaga Shusei, Nadatani Yuji, Otani Koji, Hosomi Shuhei, Tanaka Fumio, Kamata Noriko, Taira Koichi, Tanigawa Tetsuya, Watanabe Toshio, Fujiwara Yasuhiro

    GASTROINTESTINAL ENDOSCOPY   91 ( 6 )   AB420 - AB420   2020.06( ISSN:0016-5107

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  • RISK FACTORS OF MALIGNANT PROGRESSION AND FOLLOW-UP INTERVAL IN ELDERLY PATIENTS WITH BRANCH DUCT-INTRADUCTAL PAPILLARY MUCINOUS NEOPLASM Reviewed

    Yamamoto Kei, Maruyama Hirotsugu, Manabe Taku, Kimura Akie, Kakiya Yuki, Tanoue Kojiro, Hayashi Kappei, Yamamura Masafumi, Ominami Masaki, Fukunaga Shusei, Nadatani Yuji, Otani Koji, Tanaka Fumio, Taira Koichi, Kamata Noriko, Nagami Yasuaki, Tanigawa Tetsuya, Watanabe Toshio, Fujiwara Yasuhiro

    GASTROINTESTINAL ENDOSCOPY   91 ( 6 )   AB181 - AB181   2020.06( ISSN:0016-5107

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  • Endoscopic closure of refractory esophageal fistula after esophagectomy using polyglycolic acid sheets: a pilot study Reviewed

    Nagami Yasuaki, Ominami Masaki, Sakai Taishi, Fukunaga Shusei, Tanaka Fumio, Taira Koichi, Tanigawa Tetsuya, Lee Shigeru, Watanabe Toshio, Fujiwara Yasuhiro

    ENDOSCOPY INTERNATIONAL OPEN   8 ( 5 )   E591 - E595   2020.05( ISSN:2364-3722

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    DOI: 10.1055/a-1119-6352

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  • Slco2a1 deficiency exacerbates experimental colitis via inflammasome activation in macrophages: a possible mechanism of chronic enteropathy associated with SLCO2A1 gene Reviewed

    Nakata Rieko, Nakamura Yoshinobu, Hosomi Shuhei, Okuda Hiroaki, Nishida Yu, Sugita Naoko, Itani Shigehiro, Nadatani Yuji, Otani Koji, Tanaka Fumio, Kamata Noriko, Taira Koichi, Nagami Yasuaki, Tanigawa Tetsuya, Watanabe Toshio, Yamagami Hirokazu, Nakanishi Takeo, Fujiwara Yasuhiro

    SCIENTIFIC REPORTS   10 ( 1 )   4883   2020.03( ISSN:2045-2322

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    DOI: 10.1038/s41598-020-61775-9

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  • Exosomal hsa-miR-933 in Gastric Juice as a Potential Biomarker for Functional Dyspepsia. Reviewed

    Tanaka F, Takashima S, Nadatani Y, Otani K, Hosomi S, Kamata N, Taira K, Nagami Y, Tanigawa T, Fukumoto S, Watanabe T, Murakami Y, Kawada N, Fujiwara Y

    Digestive diseases and sciences   2020.01( ISSN:0163-2116

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    DOI: 10.1007/s10620-020-06096-7

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  • Endoscopic Submucosal Dissection for Esophageal Cancer Close to the Previous ESD Scar Reviewed

    Nagami Yasuaki, Ominami Masaki, Fukunaga Shusei, Sakai Taishi, Otani Koji, Hosomi Shuhei, Tanaka Fumio, Taira Koichi, Yamagami Hirokazu, Tanigawa Tetsuya, Shiba Masatsugu, Watanabe Toshio, Fujiwara Yasuhiro

    DIGESTION   101 ( 1 )   89 - 89   2020.01( ISSN:0012-2823

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  • Endoscopic Submucosal Dissection for Esophageal Cancer Close to the Previous ESD Scar Reviewed

    Nagami Yasuaki, Ominami Masaki, Fukunaga Shusei, Sakai Taishi, Otani Koji, Hosomi Shuhei, Tanaka Fumio, Taira Koichi, Yamagami Hirokazu, Tanigawa Tetsuya, Shiba Masatsugu, Watanabe Toshio, Fujiwara Yasuhiro

    DIGESTION   101 ( 1 )   89 - 89   2020.01( ISSN:0012-2823

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  • Management of Gastroesophageal Reflux Disease in Asian Countries: Results of a Questionnaire Survey Reviewed

    Hojo Mariko, Nagahara Akihito, Hahm Ki-Baik, Iwakiri Ryuichi, Watanabe Toshio, Rani Abdul Aziz, Zhu Qi, Chan Francis K. L., Sollano Jose D., Kamiya Takeshi, Yamaguchi Satoru, Motoya Satoshi, Fock Kwong Ming, Fukudo Shin, Kachintorn Udom, Suzuki Hidekazu, Murakami Kazunari

    DIGESTION   101 ( 1 )   66 - 79   2020.01( ISSN:0012-2823

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    DOI: 10.1159/000504749

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  • A Rare Case of Clival Metastasis in a Patient with Gastric Cancer Reviewed

    Yoshikawa-Kimura Akie, Taira Koichi, Katanosaka Yuki, Nakata Akinobu, Nadatani Yuji, Fukunaga Shusei, Otani Koji, Hosomi Shuhei, Tanaka Fumio, Kamata Noriko, Nagami Yasuaki, Watanabe Toshio, Fujiwara Yasuhiro

    一般社団法人 日本内科学会 INTERNAL MEDICINE   59 ( 24 )   3161 - 3164   2020( ISSN:0918-2918

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    <p>We report a rare case of clival metastasis from gastric cancer. A 73-year-old man with advanced gastric cancer treated with nivolumab as a third-line chemotherapy experienced headache, tongue deviation, and difficulties in speaking clearly. We suspected stroke or brain metastasis, but brain contrast-enhanced magnetic resonance imaging demonstrated a clival mass, diagnosed as clival metastasis from gastric cancer. The tumor could not be identified by plain computed tomography and plain magnetic resonance imaging alone. He received palliative radiotherapy (30 Gy/10 fr); his symptoms improved gradually. Although metastasis from gastric cancer to other organs is common, bone metastases are rare. </p>

    DOI: 10.2169/internalmedicine.5457-20

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  • Eosinophilic esophagitis and asymptomatic esophageal eosinophilia display similar immunohistological profiles Reviewed

    Kitamura Hiroyuki, Fukumoto Shinya, Watanabe Toshio, Kawada Norifumi, Fujiwara Yasuhiro, Tanaka Fumio, Nadatani Yuji, Otani Koji, Hosomi Shuhei, Kamata Noriko, Taira Koichi, Nagami Yasuaki, Tanigawa Tetsuya

    一般社団法人 日本酸化ストレス学会 Journal of Clinical Biochemistry and Nutrition   2020( ISSN:0912-0009

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    <p>Patients with asymptomatic esophageal eosinophilia (aEE) do not exhibit clinical symptoms because of esophageal dysfunction, although they have endoscopic and histological findings similar to those of eosinophilic esophagitis (EoE). The cause of the symptoms and the differences between aEE and EoE are unclear. The aim of this study is to determine whether aEE and EoE are same disease entities by comparing immune-related tissue biomarkers using immunohistological staining. Esophageal biopsy specimens from 61 patients, including 18 with aEE and 43 with EoE, were analyzed. Immunofluorescence staining was performed to quantify the immune-related tissue biomarkers such as major basic protein, eosinophil-derived neurotoxin, eotaxin-3, and immunoglobulin G4. Data are presented as median (interquartile range). There were no significant differences in clinical, endoscopic, or histological features, between patients with aEE and EoE, with the exception of body mass index. There were no significant differences in all immune-related tissue biomarkers between both groups. In conclusions, EoE and aEE displayed similar immunohistological profiles. Hence, they may be similar disease entities with some common pathogenic mechanisms. Our findings suggest that patients with aEE also have histopathological esophageal inflammation.</p>

    DOI: 10.3164/jcbn.20-49

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  • Current knowledge on non-steroidal anti-inflammatory drug-induced small-bowel damage: a comprehensive review. Reviewed

    Watanabe T, Fujiwara Y, Chan FKL

    Journal of gastroenterology   2019.12( ISSN:0944-1174

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    DOI: 10.1007/s00535-019-01657-8

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  • NOD-Like Receptor Family Pyrin Domain-Containing 3 Inflammasome Activation Exacerbates 5-Fluorouracil-Induced Small Intestinal Mucositis via Interleukin-1β Activation. Reviewed

    Nakata A, Nadatani Y, Watanabe T, Matsumoto Y, Kosaka S, Higashimori A, Otani K, Hosomi S, Tanaka F, Kamata N, Taira K, Nagami Y, Tanigawa T, Fujiwara Y

    Digestion   1 - 15   2019.12( ISSN:0012-2823

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    DOI: 10.1159/000504974

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  • Gastric acid inhibitor aggravates indomethacin-induced small intestinal injury via reducing Lactobacillus johnsonii Reviewed

    Nadatani Yuji, Watanabe Toshio, Suda Wataru, Nakata Akinobu, Matsumoto Yuji, Kosaka Satoshi, Higashimori Akira, Otani Koji, Hosomi Shuhei, Tanaka Fumio, Nagami Yasuaki, Kamata Noriko, Taira Koichi, Yamagami Hirokazu, Tanigawa Tetsuya, Hattori Masahira, Fujiwara Yasuhiro

    SCIENTIFIC REPORTS   9 ( 1 )   17490   2019.11( ISSN:2045-2322

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    DOI: 10.1038/s41598-019-53559-7

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  • High-fat diet-mediated dysbiosis exacerbates NSAID-induced small intestinal damage through the induction of interleukin-17A Reviewed

    Sugimura Naoki, Otani Koji, Watanabe Toshio, Nakatsu Geicho, Shimada Sunao, Fujimoto Kosuke, Nadatani Yuji, Hosomi Shuhei, Tanaka Fumio, Kamata Noriko, Taira Koichi, Nagami Yasuaki, Tanigawa Tetsuya, Uematsu Satoshi, Fujiwara Yasuhiro

    SCIENTIFIC REPORTS   9 ( 1 )   16796   2019.11( ISSN:2045-2322

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    DOI: 10.1038/s41598-019-52980-2

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  • Successful Eradication of Helicobacter pylori Could Prevent Metachronous Gastric Cancer: A Propensity Matching Analysis. Reviewed

    Nakata R, Nagami Y, Hashimoto A, Sakai T, Ominami M, Fukunaga S, Otani K, Hosomi S, Tanaka F, Ohira M, Taira K, Yamagami H, Tanigawa T, Watanabe T, Fujiwara Y

    Digestion   1 - 10   2019.11( ISSN:0012-2823

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    DOI: 10.1159/000504132

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  • Positive correlation between pancreatic volume and post-endoscopic retrograde cholangiopancreatography pancreatitis. Reviewed

    Maruyama H, Shiba M, Ishikawa-Kakiya Y, Kato K, Ominami M, Fukunaga S, Otani K, Hosomi S, Tanaka F, Kamata N, Taira K, Nagami Y, Yamagami H, Tanigawa T, Watanabe T, Yamamoto A, Kabata D, Shintani A, Fujiwara Y

    Journal of gastroenterology and hepatology   2019.10( ISSN:0815-9319

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    DOI: 10.1111/jgh.14878

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  • Endoscopic closure using polyglycolic acid sheets for delayed perforation after colonic endoscopic submucosal dissection. Reviewed

    Nagami Y, Fukunaga S, Kanamori A, Sakai T, Ominami M, Watanabe T, Fujiwara Y

    Endoscopy   2019.08( ISSN:0013-726X

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    DOI: 10.1055/a-0978-4501

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  • アザチオプリンは、潰瘍性大腸炎治療に対するタクロリムス投与で誘導される長期寛解の維持に有用である 治療の逆確率重み付け解析(Azathioprine Is Useful for Maintaining Long-term Remission Induced by Tacrolimus for the Treatment of Ulcerative Colitis: An Inverse Probability of a Treatment Weighing Analysis) Reviewed

    Nishida Yu, Hosomi Shuhei, Yamagami Hirokazu, Sugita Naoko, Itani Shigehiro, Yukawa Tomomi, Otani Koji, Nagami Yasuaki, Tanaka Fumio, Taira Koichi, Kamata Noriko, Kakimoto Kazuki, Tanigawa Tetsuya, Watanabe Toshio, Fujiwara Yasuhiro

    Internal Medicine   58 ( 16 )   2305 - 2313   2019.08( ISSN:0918-2918

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    経口タクロリムス投与を開始した中等度-重度の活動性潰瘍性大腸炎(UC)患者63例(男性35例、女性28例、中央値39.8歳)を対象に、寛解維持のための免疫調節薬(IM)の有効性を後向きに評価した。主要評価項目はUCの臨床的再発とした。45例(71.4%)が維持療法としてIMが投与された(アザチオプリン43例、6-メルカプトプリン2例)。追跡期間中(中央値14.2ヵ月)に30例(47.6%)が再発し、このうちIM投与群は18例(40.0%)、非投与群は12例(66.7%)であった(p=0.093)。IM非投与群は投与群に比べて2年無再発生存率が有意に低かった(22.5 vs 63.6%)。多変量調整後、IMは臨床的再発の独立した保護因子であった(調整ハザード比0.35,95%CI 0.16〜0.78,p=0.01)。治療の逆確率重み付けを用いたCox回帰解析でも同様であった(ハザード比0.31,95%CI 0.15〜0.64,p<0.01)。タクロリムスやIMによる重篤な有害事象(AE)は認めず、IMはタクロリムスにより引き起こされるAEの発生率を上昇させなかった。

  • Obesity and hiatal hernia may be non-allergic risk factors for esophageal eosinophilia in Japanese adults Reviewed

    Tanaka Fumio, Fukumoto Shinya, Morisaki Tamami, Otani Koji, Hosomi Shuhei, Nagami Yasuaki, Kamata Noriko, Taira Koichi, Nakano Akemi, Kimura Tatsuo, Yamagami Hirokazu, Tanigawa Tetsuya, Morikawa Hiroyasu, Watanabe Toshio, Kawada Norifumi, Hirata Kazuto, Fujiwara Yasuhiro

    ESOPHAGUS   16 ( 3 )   309 - 315   2019.07( ISSN:1612-9059

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    DOI: 10.1007/s10388-019-00662-3

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  • 日本人成人における肥満と裂孔ヘルニアは食道好酸球浸潤の非アレルギー性危険因子である可能性がある(Obesity and hiatal hernia may be non-allergic risk factors for esophageal eosinophilia in Japanese adults) Reviewed

    Tanaka Fumio, Fukumoto Shinya, Morisaki Tamami, Otani Koji, Hosomi Shuhei, Nagami Yasuaki, Kamata Noriko, Taira Koichi, Nakano Akemi, Kimura Tatsuo, Yamagami Hirokazu, Tanigawa Tetsuya, Morikawa Hiroyasu, Watanabe Toshio, Kawada Norifumi, Hirata Kazuto, Fujiwara Yasuhiro

    Esophagus   16 ( 3 )   309 - 315   2019.07( ISSN:1612-9059

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    食道好酸球浸潤(EE)の非アレルギー性危険因子について横断研究により検討した。健康診断において消化管内視鏡検査を受けた被検者を対象とした。EE被験者(男性15名、女性12名、年齢中央値45歳)と非EE被験者(男性2803名、女性3134名、年齢中央値51歳)の臨床的特徴を比較した。EEの検出率は0.45%であった。EE被験者の20名は症候性、7名は無症候性であった。単変量解析の結果、非EE被験者と比較してEE被検者はBMIが有意に高かった。内視鏡所見において、EE被検者は裂孔ヘルニアの割合が有意に高かった。EE被検者は年齢が有意に若く、気管支喘息の割合が高かった。多変量解析の結果、非EE被験者と比較してEE被検者はBMIおよび裂孔ヘルニアと正に関連していた。傾向検定において、高いBMI分類は有意なEE有病率増加傾向を示した。

  • 重症併存症がみられる患者の早期胃癌に対する内視鏡的粘膜下層剥離術の晩期成績 傾向スコアを用いた比較解析(Long-term outcome of endoscopic submucosal dissection for early gastric cancer in patients with severe comorbidities: a comparative propensity score analysis) Reviewed

    Tanoue Kojiro, Fukunaga Shusei, Nagami Yasuaki, Sakai Taishi, Maruyama Hirotsugu, Ominami Masaki, Otani Koji, Hosomi Shuhei, Tanaka Fumio, Taira Koichi, Kamata Noriko, Yamagami Hirokazu, Tanigawa Tetsuya, Shiba Masatsugu, Watanabe Toshio, Fujiwara Yasuhiro

    シュプリンガー・ジャパン(株) Gastric Cancer   22 ( 3 )   558 - 566   2019.05( ISSN:1436-3291

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    早期胃癌の患者に対し内視鏡的粘膜下層剥離術(ESD)を施行した場合の晩期成績を重症併存症の有無で比較する後ろ向きコホート研究を施行した。早期胃癌に罹患し、当院にて2004年2月〜2013年6月にESDを施行され、2016年7月まで経過観察が続けられた患者488名を解析対象とした。そのうち、米国麻酔科学会術前全身状態分類(ASA-PS)にてクラス1または2と分類された患者は375名(対照群)、3と分類され重症併存症を有すると定義された患者は113名(重症併存症群)であった。傾向スコア分析にて比較した結果、重症併存症群の5年全生存率は79.1%であり、対照群での87.7%よりも有意に低かった。Cox比例ハザード回帰分析およびinverse probability of treatment weighting法による分析を施行した結果、どちらの分析方法を用いた場合でも重症併存症群に属することは死亡に関し有意な危険因子となることが示された。有害事象については、傾向スコアマッチングを行った後の両群間において有意差は認められなかった。重症の併存症を有する早期胃癌患者では、重症併存症がみられない患者に比べESDの長期予後が悪化することが示された。

  • 重症併存症がみられる患者の早期胃癌に対する内視鏡的粘膜下層剥離術の晩期成績 傾向スコアを用いた比較解析(Long-term outcome of endoscopic submucosal dissection for early gastric cancer in patients with severe comorbidities: a comparative propensity score analysis) Reviewed

    Tanoue Kojiro, Fukunaga Shusei, Nagami Yasuaki, Sakai Taishi, Maruyama Hirotsugu, Ominami Masaki, Otani Koji, Hosomi Shuhei, Tanaka Fumio, Taira Koichi, Kamata Noriko, Yamagami Hirokazu, Tanigawa Tetsuya, Shiba Masatsugu, Watanabe Toshio, Fujiwara Yasuhiro

    シュプリンガー・ジャパン(株) Gastric Cancer   22 ( 3 )   558 - 566   2019.05( ISSN:1436-3291

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    早期胃癌の患者に対し内視鏡的粘膜下層剥離術(ESD)を施行した場合の晩期成績を重症併存症の有無で比較する後ろ向きコホート研究を施行した。早期胃癌に罹患し、当院にて2004年2月〜2013年6月にESDを施行され、2016年7月まで経過観察が続けられた患者488名を解析対象とした。そのうち、米国麻酔科学会術前全身状態分類(ASA-PS)にてクラス1または2と分類された患者は375名(対照群)、3と分類され重症併存症を有すると定義された患者は113名(重症併存症群)であった。傾向スコア分析にて比較した結果、重症併存症群の5年全生存率は79.1%であり、対照群での87.7%よりも有意に低かった。Cox比例ハザード回帰分析およびinverse probability of treatment weighting法による分析を施行した結果、どちらの分析方法を用いた場合でも重症併存症群に属することは死亡に関し有意な危険因子となることが示された。有害事象については、傾向スコアマッチングを行った後の両群間において有意差は認められなかった。

  • Long-term outcome of endoscopic submucosal dissection for early gastric cancer in patients with severe comorbidities: a comparative propensity score analysis. Reviewed

    Tanoue K, Fukunaga S, Nagami Y, Sakai T, Maruyama H, Ominami M, Otani K, Hosomi S, Tanaka F, Taira K, Kamata N, Yamagami H, Tanigawa T, Shiba M, Watanabe T, Fujiwara Y

    Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association   22 ( 3 )   558 - 566   2019.05( ISSN:1436-3291

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    DOI: 10.1007/s10120-018-0889-8

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  • 日本人被験者においてBarrett食道は好酸球性食道炎と負に関連する(Barrett's esophagus is negatively associated with eosinophilic esophagitis in Japanese subjects) Reviewed

    Takashima Shingo, Tanaka Fumio, Otani Koji, Hosomi Shuhei, Nagami Yasuaki, Kamata Noriko, Taira Koichi, Yamagami Hirokazu, Tanigawa Tetsuya, Fukumoto Shinya, Watanabe Toshio, Fujiwara Yasuhiro

    シュプリンガー・ジャパン(株) Esophagus   16 ( 2 )   168 - 173   2019.04( ISSN:1612-9059

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    好酸球性食道炎(EoF)とBarrett食道(BE)との臨床的関係性を調査した。2015年1月〜2017年9月に当施設に来院した日本人EoF患者95例(女性38例、男性57例、平均45.9±10.5歳)と当施設で人間ドックを受けた非EoF対照190名(女性76名、男性114名、平均45.9±10.5歳)を後ろ向きに調査した。臨床的特徴と、BE、逆流性食道炎(RE)、食道裂孔ヘルニア、萎縮性胃炎の有病率をEoF患者と対照で比較し、これらの因子とEoFとの関連を調査した。BEの有病率はEoF患者が2.1%で、対照の13.2%よりも有意に低かった。REの有病率は対照よりもEoF患者で高かったが有意ではなかった。食道裂孔ヘルニア、萎縮性胃炎の有病率は2群間で有意差がなかった。多変量解析ではBEはEoFと有意に負に関連し、BMIはEoFと正に関連した。

  • 日本人被験者においてBarrett食道は好酸球性食道炎と負に関連する(Barrett's esophagus is negatively associated with eosinophilic esophagitis in Japanese subjects) Reviewed

    Takashima Shingo, Tanaka Fumio, Otani Koji, Hosomi Shuhei, Nagami Yasuaki, Kamata Noriko, Taira Koichi, Yamagami Hirokazu, Tanigawa Tetsuya, Fukumoto Shinya, Watanabe Toshio, Fujiwara Yasuhiro

    シュプリンガー・ジャパン(株) Esophagus   16 ( 2 )   168 - 173   2019.04( ISSN:1612-9059

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    好酸球性食道炎(EoF)とBarrett食道(BE)との臨床的関係性を調査した。2015年1月〜2017年9月に当施設に来院した日本人EoF患者95例(女性38例、男性57例、平均45.9±10.5歳)と当施設で人間ドックを受けた非EoF対照190名(女性76名、男性114名、平均45.9±10.5歳)を後ろ向きに調査した。臨床的特徴と、BE、逆流性食道炎(RE)、食道裂孔ヘルニア、萎縮性胃炎の有病率をEoF患者と対照で比較し、これらの因子とEoFとの関連を調査した。BEの有病率はEoF患者が2.1%で、対照の13.2%よりも有意に低かった。REの有病率は対照よりもEoF患者で高かったが有意ではなかった。食道裂孔ヘルニア、萎縮性胃炎の有病率は2群間で有意差がなかった。多変量解析ではBEはEoFと有意に負に関連し、BMIはEoFと正に関連した。

  • Association between endoscopic findings of eosinophilic esophagitis and responsiveness to proton pump inhibitors Reviewed

    Sawada Akinari, Hashimoto Atsushi, Uemura Risa, Otani Koji, Tanaka Fumio, Nagami Yasuaki, Yamagami Hirokazu, Tanigawa Tetsuya, Watanabe Toshio, Fujiwara Yasuhiro

    ENDOSCOPY INTERNATIONAL OPEN   7 ( 4 )   E433 - E439   2019.04( ISSN:2364-3722

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    DOI: 10.1055/a-0859-7276

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  • Effect of EP1 Receptor Antagonist on Transient Lower Esophageal Sphincter Relaxations in Humans. Reviewed

    Sawada A, Hashimoto A, Uemura R, Yamagami H, Tanigawa T, Watanabe T, Fujiwara Y

    Digestion   1 - 9   2019.03( ISSN:0012-2823

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    DOI: 10.1159/000499333

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  • Pretreatment neutrophil-to-lymphocyte ratio predicts clinical relapse of ulcerative colitis after tacrolimus induction Reviewed

    Nishida Yu, Hosomi Shuhei, Yamagami Hirokazu, Sugita Naoko, Itani Shigehiro, Yukawa Tomomi, Otani Koji, Nagami Yasuaki, Tanaka Fumio, Taira Koichi, Kamata Noriko, Tanigawa Tetsuya, Watanabe Toshio, Fujiwara Yasuhiro

    PLOS ONE   14 ( 3 )   e0213505   2019.03( ISSN:1932-6203

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    DOI: 10.1371/journal.pone.0213505

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  • Endoscopic technique for closure of a large gastric tube perforation by using endoclips with line-assisted complete closure Reviewed

    Ominami Masaki, Nagami Yasuaki, Tanaka Chieko, Sakai Taishi, Fukunaga Shusei, Watanabe Toshio, Fujiwara Yasuhiro

    ENDOSCOPY   51 ( 3 )   E49 - E50   2019.03( ISSN:0013-726X

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    DOI: 10.1055/a-0800-8502

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  • Cannulation into the minor papilla using the bile duct guidewire method Reviewed

    Maruyama Hirotsugu, Watanabe Toshio, Fujiwara Yasuhiro

    DIGESTIVE ENDOSCOPY   31 ( 2 )   e44 - e45   2019.03( ISSN:0915-5635

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    DOI: 10.1111/den.13331

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  • Changes in Clock Genes Expression in Esophagus in Rat Reflux Esophagitis. Reviewed

    Hashimoto A, Uemura R, Sawada A, Nadatani Y, Otani K, Hosomi S, Nagami Y, Tanaka F, Kamata N, Taira K, Yamagami H, Tanigawa T, Watanabe T, Fujiwara Y

    Digestive diseases and sciences   2019.02( ISSN:0163-2116

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    DOI: 10.1007/s10620-019-05546-1

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  • Involvement of gliadin, a component of wheat gluten, in increased intestinal permeability leading to non-steroidal anti-inflammatory drug-induced small-intestinal damage Reviewed

    Shimada Sunao, Tanigawa Tetsuya, Watanabe Toshio, Nakata Akinobu, Sugimura Naoki, Itani Shigehiro, Higashimori Akira, Nadatani Yuji, Otani Koji, Taira Koichi, Hosomi Shuhei, Nagami Yasuaki, Tanaka Fumio, Kamata Noriko, Yamagami Hirokazu, Shiba Masatsugu, Fujiwara Yasuhiro

    PLOS ONE   14 ( 2 )   e0211436   2019.02( ISSN:1932-6203

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    DOI: 10.1371/journal.pone.0211436

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  • 日本人被験者における機能性ディスペプシアと陥凹型胃びらんとの関連性(Association between Functional Dyspepsia and Gastric Depressive Erosions in Japanese Subjects) Reviewed

    Tanaka Fumio, Tominaga Kazunari, Fujikawa Yoshiko, Morisaki Tamami, Otani Koji, Hosomi Shuhei, Nagami Yasuaki, Kamata Noriko, Taira Koichi, Nakano Akemi, Kimura Tatsuo, Yamagami Hirokazu, Tanigawa Tetsuya, Morikawa Hiroyasu, Fukumoto Shinya, Watanabe Toshio, Kawada Norifumi, Hirata Kazuto, Fujiwara Yasuhiro

    (一社)日本内科学会 Internal Medicine   58 ( 3 )   321 - 328   2019.02( ISSN:0918-2918

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    機能性ディスペプシア(FD)の自験例を対象に、FDに関連する内視鏡所見を胃炎の京都分類に従って調査する横断研究を施行した。当院にて上部消化管内視鏡検査を施行された健診受診者のうち、器質的疾患がみられた例などを除外した456名を解析対象とした。そのうち5.5%に当たる25名(女性14名、年齢中央値47.0歳)がFDと診断され(罹患群)、残りの431名は健康と判定された(健康対照群)。両群の内視鏡検査所見を単変量解析にて比較した結果、稜線状発赤がみられた被験者の割合は罹患群で0%、健康対照群で18.6%と罹患群の方が有意に低く、逆に陥凹型びらんの割合はそれぞれ20.0%、7.9%と罹患群の方が高く、そのp値は0.0522であった。びらんが陽性の集団におけるFD罹患者の割合は12.8%で、びらん陰性集団での4.8%よりも高かった。胃炎の京都分類に記載されているその他の内視鏡所見に関しては両群間で有意差は示されなかった。単変量解析で関連性が示された2種の所見に関し多変量解析を行ったところ、陥凹型びらん所見陽性のみがFD罹患に対する独立関連因子であることが有意に示された(オッズ比2.92、95%信頼区間1.03〜8.26)。以上の結果から、陥凹型びらん所見はFDと関連していると考えられた。

  • 日本人被験者における機能性ディスペプシアと陥凹型胃びらんとの関連性(Association between Functional Dyspepsia and Gastric Depressive Erosions in Japanese Subjects) Reviewed

    Tanaka Fumio, Tominaga Kazunari, Fujikawa Yoshiko, Morisaki Tamami, Otani Koji, Hosomi Shuhei, Nagami Yasuaki, Kamata Noriko, Taira Koichi, Nakano Akemi, Kimura Tatsuo, Yamagami Hirokazu, Tanigawa Tetsuya, Morikawa Hiroyasu, Fukumoto Shinya, Watanabe Toshio, Kawada Norifumi, Hirata Kazuto, Fujiwara Yasuhiro

    (一社)日本内科学会 Internal Medicine   58 ( 3 )   321 - 328   2019.02( ISSN:0918-2918

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    機能性ディスペプシア(FD)の自験例を対象に、FDに関連する内視鏡所見を胃炎の京都分類に従って調査する横断研究を施行した。当院にて上部消化管内視鏡検査を施行された健診受診者のうち、器質的疾患がみられた例などを除外した456名を解析対象とした。そのうち5.5%に当たる25名(女性14名、年齢中央値47.0歳)がFDと診断され(罹患群)、残りの431名は健康と判定された(健康対照群)。両群の内視鏡検査所見を単変量解析にて比較した結果、稜線状発赤がみられた被験者の割合は罹患群で0%、健康対照群で18.6%と罹患群の方が有意に低く、逆に陥凹型びらんの割合はそれぞれ20.0%、7.9%と罹患群の方が高く、そのp値は0.0522であった。びらんが陽性の集団におけるFD罹患者の割合は12.8%で、びらん陰性集団での4.8%よりも高かった。胃炎の京都分類に記載されているその他の内視鏡所見に関しては両群間で有意差は示されなかった。単変量解析で関連性が示された2種の所見に関し多変量解析を行ったと

  • Comparison Between the Efficacy of Radial- and Convex-Arrayed Echoendoscopes for Indirect Findings of Pancreatic Cancer at an Early Stage Reviewed

    Ishikawa-Kakiya Y., Maruyama H., Tanoue K., Hayashi K., Yamamura M., Taira K., Nagami Y., Tanigawa T., Watanabe T., Fujiwara Y.

    PANCREAS   48 ( 10 )   1451 - 1451   2019( ISSN:0885-3177

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  • Comparison Between the Efficacy of Radial- and Convex-Arrayed Echoendoscopes for Indirect Findings of Pancreatic Cancer at an Early Stage Reviewed

    Ishikawa-Kakiya Y, Maruyama H, Tanoue K, Hayashi K, Yamamura M, Taira K, Nagami Y, Tanigawa T, Watanabe T, Fujiwara Y

    PANCREAS   48 ( 10 )   1451 - 1451   2019( ISSN:0885-3177

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  • Fluorouracil(5-FU)起因性小腸粘膜傷害はNLRP3 inflammasomeによるIL-1<i>β</i>の活性化により誘導される Reviewed

    中田 晃暢, 灘谷 祐二, 小阪 聡, 松本 侑士, 大谷 恒史, 谷川 徹也, 渡辺 俊雄, 藤原 靖弘

    日本小腸学会 日本小腸学会学術集会プログラム・抄録集   3 ( 0 )   42_2 - 42_2   2019( ISSN:2434-2912

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    <p>【背景】 NLRP3 inflammasomeはNLRP3およびpro-Caspase-1、ASCから構成され、cleaved Caspase-1を介してpro-IL-1<i>β</i>・IL-18を活性型であるmature IL-1<i>β</i>・IL-18に変換することで炎症を惹起する。5-FUは炎症性サイトカイン上昇を伴う小腸粘膜傷害を惹起することが知られているが、NLRP3 inflammasomeの5-FU起因性小腸粘膜傷害における役割は現在明らかではない。</p><p>【目的】 5-FU起因性小腸粘膜傷害におけるNLRP3 inflammasomeの役割を明らかにする。</p><p>【方法】 小腸粘膜傷害は雄性Wild Type(WT)、Caspase-1<sup>-/-</sup>、NLRP3<sup>-/-</sup>マウスに5-FUを腹腔内投与(500mg/kg)することによって惹起した。同WTモデルマウスにrecombinant IL-1<i>β</i>またはIL-18(0.1μgまたは1μg/kg/日)を腹腔内投与した。抗IL-1<i>β</i>中和抗体(100<i>μ</i>g/匹/日)を投与した。Caspase-1阻害薬(Ac-YVAD-CMK; 1mgまたは10mg/kg/日)を投与した。マウス各群の体重変化・下痢の程度や、小腸組織の組織学的検討、炎症及びNLRP3 inflammasome関連分子の発現解析を行った。</p><p>【結果】 組織学的検討では、5-FU投与後3日目を最大として絨毛高が低下し、強い炎症性変化を認めた。それはKCとTNF-<i>α</i>のmRNA発現量の増加を伴った。5-FU投与後3日目に、mature-IL-1<i>β</i>、cleaved Caspase-1、並びにNLRP3の蛋白質発現量の増加を認めた。しかし、5-FU投与後3日目にmature IL-18の増加は認めなかった。Recombinant IL-1<i>β</i>投与群で小腸粘膜傷害は増悪したが、中和抗体投与群では粘膜傷害は改善した。一方、recombinant IL-18投与群では粘膜傷害の程度に有意な変化は無かった。Ac-YVAD-cmk投与群、Caspase-1<sup>-/-</sup>とNLRP3<sup>-/-</sup>マウス群では小腸粘膜傷害は軽減した。5-FU投与はmature IL-1<i>β</i>とNLRP3 inflammasome関連分子の発現を増加させ、小腸粘膜傷害を惹起した。そして、IL-1<i>β</i>の投与は小腸粘膜傷害を増悪させ、IL-1<i>β</i>、Caspase-1、並びNLRP3の阻害は小腸粘膜傷害を抑制した。</p><p>【結語】 5-FU起因性小腸粘膜傷害はNLRP3 inflammasomeによるIL-1<i>β</i>の活性化により誘導されることが明らかになった。</p>

    DOI: 10.32264/shocho.3.0_42_2

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  • Azathioprine Is Useful for Maintaining Long-term Remission Induced by Tacrolimus for the Treatment of Ulcerative Colitis: An Inverse Probability of a Treatment Weighing Analysis Reviewed

    Nishida Yu, Hosomi Shuhei, Yamagami Hirokazu, Sugita Naoko, Otani Koji, Nagami Yasuaki, Tanaka Fumio, Taira Koichi, Kamata Noriko, Kakimoto Kazuki, Tanigawa Tetsuya, Watanabe Toshio, Fujiwara Yasuhiro

    一般社団法人 日本内科学会 INTERNAL MEDICINE   58 ( 16 )   2305 - 2313   2019( ISSN:0918-2918

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    <p><b>Objective </b>The need for and efficacy of immunomodulators for maintaining remission after tacrolimus therapy have not been sufficiently defined. This study evaluated the efficacy of immunomodulators for maintaining remission in patients with ulcerative colitis after tacrolimus therapy. </p><p><b>Methods </b>Patients with active ulcerative colitis who started oral tacrolimus between January 2009 and September 2017 and were responsive were retrospectively evaluated. Long-term outcomes were compared using Cox proportional hazard regression with inverse probability of treatment weighting. </p><p><b>Results </b>Among the 63 patients in the study, 45 received immunomodulators. During the follow-up, 30 patients (47.6%) experienced a relapse. The relapse-free survival rate was significantly worse in the group that did not receive immunomodulators than in those that did (p=0.01, log-rank test); the 2-year relapse-free rates were 22.5% and 63.6% in the non-immunomodulator and immunomodulator groups, respectively. A multivariate analysis showed immunomodulator treatment to be an independent protective factor for clinical relapse (adjusted hazard ratio: 0.35, 95% confidence interval: 0.16-0.78, p=0.01). A Cox regression analysis using inverse probability of treatment weighting also showed that immunomodulator maintenance therapy was correlated with a longer relapse-free survival (hazard ratio: 0.31, 95% confidence interval: 0.15-0.64, p<0.01), A similar response was also observed in non-steroid-dependent patients (hazard ratio: 0.36, 95% confidence interval: 0.14-0.99, p=0.047). No serious adverse events occurred due to tacrolimus or immunomodulator, and immunomodulator use did not increase the incidence of adverse events caused by tacrolimus. </p><p><b>Conclusion </b>Our data suggest that the use of immunomodulators to maintain remission after tacrolimus therapy is beneficial for patients with ulcerative colitis. </p>

    DOI: 10.2169/internalmedicine.2632-19

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  • [Current knowledge of mechanisms of drugs-induced gastrointestinal damage]. Reviewed

    Watanabe T, Fujiwara Y

    Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology   116 ( 6 )   468 - 478   2019( ISSN:0446-6586

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    DOI: 10.11405/nisshoshi.116.468

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  • Questionnaire-Based Survey on Management of Ulcerative Colitis-Associated Cancer in East Asian Countries. Reviewed

    Yamaguchi S, Sasaki K, Kato H, Fukudo S, Iwakiri R, Kamiya T, Motoya S, Murakami K, Nagahara A, Suzuki H, Watanabe T, Takahashi S, Chan FKL, Hahm KB, Kachintorn U, Ming FK, Rani AA, Sollano JD, Zhu Q

    Digestion   99 ( 1 )   86 - 94   2019( ISSN:0012-2823

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    DOI: 10.1159/000494419

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  • Colorectal polyps located across a fold are difficult to resect completely using endoscopic mucosal resection: A propensity score analysis Reviewed

    Minamino Hiroaki, Nagami Yasuaki, Shiba Masatsugu, Hayashi Kappei, Sakai Taishi, Ominami Masaki, Fukunaga Shusei, Hayakawa Tsuyoshi, Aomatsu Kazuki, Sugimori Satoshi, Tanigawa Tetsuya, Yamagami Hirokazu, Watanabe Toshio, Fujiwara Yasuhiro

    UNITED EUROPEAN GASTROENTEROLOGY JOURNAL   6 ( 10 )   1547 - 1555   2018.12( ISSN:2050-6406

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    DOI: 10.1177/2050640618797854

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  • Optimal Biopsy Protocol to Evaluate Histological Effectiveness of Proton Pump Inhibitor Therapy in Patients with Eosinophilic Esophagitis. Reviewed

    Fujiwara Y, Hashimoto A, Uemura R, Sawada A, Otani K, Tanaka F, Yamagami H, Tanigawa T, Watanabe T, Kabata D, Kuwae Y, Shintani A, Ohsawa M

    Digestion   1 - 8   2018.11( ISSN:0012-2823

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    DOI: 10.1159/000494253

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  • Heparin-bridging therapy is associated with post-colorectal polypectomy bleeding in patients whose oral anticoagulation therapy is interrupted Reviewed

    Sakai Taishi, Nagami Yasuaki, Shiba Masatsugu, Hayashi Kappei, Kinoshita Yosuke, Maruyama Hirotsugu, Kato Kunihiro, Minamino Hiroaki, Ominami Masaki, Fukunaga Shusei, Otani Koji, Hosomi Shuhei, Tanaka Fumio, Taira Koichi, Kamata Noriko, Yamagami Hirokazu, Tanigawa Tetsuya, Watanabe Toshio, Fujiwara Yasuhiro

    SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY   53 ( 10-11 )   1304 - 1310   2018.11( ISSN:0036-5521

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    DOI: 10.1080/00365521.2018.1503325

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  • A retrospective study comparing the Franseen and Lancet needles in EUS-FNA of solid pancreatic lesions Reviewed

    Ishikawa-Kakiya Yuki, Maruyama Hirotsugu, Hayashi Kappei, Kinoshita Yosuke, Tanoue Kojirou, Yamamura Masafumi, Ominami Masaki, Fukunaga Shusei, Nagami Yasuaki, Taira Koichi, Yamagami Hirokazu, Tanigawa Tetsuya, Watanabe Toshio, Fujiwara Yasuhiro

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   33   279 - 279   2018.11( ISSN:0815-9319

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  • Barrett's esophagus is negatively associated with eosinophilic esophagitis in Japanese subjects. Reviewed

    Takashima S, Tanaka F, Otani K, Hosomi S, Nagami Y, Kamata N, Taira K, Yamagami H, Tanigawa T, Fukumoto S, Watanabe T, Fujiwara Y

    Esophagus : official journal of the Japan Esophageal Society   2018.10( ISSN:1612-9059

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    DOI: 10.1007/s10388-018-0648-2

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  • Lymph Node Metastasis of Mixed Adenoneuroendocrine Carcinoma after Curative Resection Using the Expanded Criteria for Early Gastric Cancer(和訳中) Reviewed

    Ochiai Tadashi, Ominami Masaki, Nagami Yasuaki, Fukunaga Shusei, Toyokawa Takahiro, Yamagami Hirokazu, Tanigawa Tetsuya, Watanabe Toshio, Ohira Masaichi, Ohsawa Masahiko, Fujiwara Yasuhiro

    (一社)日本内科学会 Internal Medicine   57 ( 19 )   2837 - 2842   2018.10( ISSN:0918-2918

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  • Association between Functional Dyspepsia and Gastric Depressive Erosions in Japanese Subjects. Reviewed

    Tanaka F, Tominaga K, Fujikawa Y, Morisaki T, Otani K, Hosomi S, Nagami Y, Kamata N, Taira K, Nakano A, Kimura T, Yamagami H, Tanigawa T, Morikawa H, Fukumoto S, Watanabe T, Kawada N, Hirata K, Fujiwara Y

    Internal medicine (Tokyo, Japan)   2018.09( ISSN:0918-2918

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    DOI: 10.2169/internalmedicine.1325-18

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  • Impact of preoperative biopsy on severe submucosal fibrosis on endoscopic submucosal dissection for colorectal laterally spreading tumors: a propensity score analysis. Reviewed

    Fukunaga S, Nagami Y, Shiba M, Sakai T, Maruyama H, Ominami M, Otani K, Hosomi S, Tanaka F, Taira K, Tanigawa T, Yamagami H, Watanabe T, Fujiwara Y

    Gastrointestinal endoscopy   2018.09( ISSN:0016-5107

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    DOI: 10.1016/j.gie.2018.08.051

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  • Microbiome and intestinal ischemia/reperfusion injury Reviewed

    Nadatani Yuji, Watanabe Toshio, Shimada Sunao, Otani Koji, Tanigawa Tetsuya, Fujiwara Yasuhiro

    SOCIETY FOR FREE RADICAL RESEARCH JAPAN, J. Clin. Biochem. Nutr.   63 ( 1 )   26 - 32   2018.07( ISSN:0912-0009

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    <p>Intestinal ischemia/reperfusion injury is a severe disease associated with a high mortality. The mechanisms that cause ischemia/reperfusion injury are complex and many factors are involved in the injury formation process; however, the only available treatment is surgical intervention. Recent studies demonstrated that the intestinal microbiome plays a key role in intestinal ischemia/reperfusion injury and there are many factors associated with intestinal bacteria during the formation of the intestinal ischemia/reperfusion injury. Among the Toll-like receptors (TLR), TLR2, TLR4, and their adaptor protein, myeloid differentiation primary-response 88 (MyD88), have been reported to be involved in intestinal ischemia/reperfusion injury. Oxidative stress and nitric oxide are also associated with intestinal bacteria during the formation of the intestinal ischemia/reperfusion injury. This review focuses on our current understanding of the impact of the microbiome, including the roles of the TLRs, oxidative stress, and nitric oxide, on intestinal ischemia/reperfusion injury.</p>

    DOI: 10.3164/jcbn.17-137

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  • Usefulness of small bowel reexamination in obscure gastrointestinal bleeding patients with negative capsule endoscopy findings: Comparison of repeat capsule endoscopy and double-balloon enteroscopy Reviewed

    Otani Koji, Watanabe Toshio, Shimada Sunao, Nadatani Yuji, Hosomi Shuhei, Nagami Yasuaki, Tanaka Fumio, Kamata Noriko, Taira Koichi, Yamagami Hirokazu, Tanigawa Tetsuya, Shiba Masatsugu, Fujiwara Yasuhiro

    UNITED EUROPEAN GASTROENTEROLOGY JOURNAL   6 ( 6 )   879 - 887   2018.07( ISSN:2050-6406

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    DOI: 10.1177/2050640618767600

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  • Misoprostol Heals Small Bowel Ulcers in Aspirin Users With Small Bowel Bleeding. Reviewed

    Kyaw MH, Otani K, Ching JYL, Higashimori A, Kee KM, Watanabe T, Tse YK, Lee V, Tanigawa T, Cheong PK, Suen BY, Fujiwara Y, Lam K, Arakawa T, Chan FKL

    Gastroenterology   2018.06( ISSN:0016-5085

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    DOI: 10.1053/j.gastro.2018.06.056

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  • ADVERSE EVENTS OF ENDOSCOPIC BALLOON DILATATION FOR ESOPHAGEAL STRICTURE CAUSED BY ENDOSCOPIC SUBMUCOSAL DISSECTION Reviewed

    Nakamura Yoshihiro, Nagami Yasuaki, Yamamura Masafumi, Hayashi Kappei, Kinoshita Yosuke, Tanoue Koujiro, Sakai Taishi, Maruyama Hirotsugu, Kato Kunihiro, Ominami Masaki, Fukunaga Shusei, Sugimori Satoshi, Otani Koji, Hosomi Shuhei, Tanaka Fumio, Taira Koichi, Kamata Noriko, Yamagami Hirokazu, Tanigawa Tetsuya, Shiba Masatsugu, Watanabe Toshio, Fujiwara Yasuhiro

    GASTROINTESTINAL ENDOSCOPY   87 ( 6 )   AB88 - AB89   2018.06( ISSN:0016-5107

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  • SUCCESSFUL ERADICATION OF HELICOBACTER PYLORI REDUCES THE DEVELOPMENT OF METACHRONOUS GASTRIC CANCER AFTER ENDOSCOPIC SUBMUCOSAL DISSECTION FOR EARLY GASTRIC CANCER: A PROPENSITY MATCHING ANALYSIS Reviewed

    Nakata Rieko, Nagami Yasuaki, Hashimoto Atsushi, Sakai Taishi, Ominami Masaki, Fukunaga Shusei, Otani Koji, Hosomi Shuhei, Tanaka Fumio, Ohira Mizuki, Kamata Noriko, Taira Koichi, Yamagami Hirokazu, Tanigawa Tetsuya, Shiba Masatsugu, Watanabe Toshio, Fujiwara Yasuhiro

    GASTROINTESTINAL ENDOSCOPY   87 ( 6 )   AB52 - AB53   2018.06( ISSN:0016-5107

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  • Combined Infection of Human Herpes Viruses: A Risk Factor for Subsequent Colectomy in Ulcerative Colitis Reviewed

    Hosomi Shuhei, Watanabe Kenji, Nishida Yu, Yamagami Hirokazu, Yukawa Tomomi, Otani Koji, Nagami Yasuaki, Tanaka Fumio, Taira Koichi, Kamata Noriko, Tanigawa Tetsuya, Shiba Masatsugu, Watanabe Toshio, Nagahara Hisashi, Maeda Kiyoshi, Fujiwara Yasuhiro

    INFLAMMATORY BOWEL DISEASES   24 ( 6 )   1307 - 1315   2018.06( ISSN:1078-0998

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    DOI: 10.1093/ibd/izy005

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  • CAN THE ORBIT SCORE PREDICT DELAYED BLEEDING AFTER COLORECTAL ENDOSCOPIC SUBMUCOSAL DISSECTION IN PATIENTS RECEIVING ORAL ANTICOAGULATION THERAPY? Reviewed

    Fukunaga Shusei, Nagami Yasuaki, Sakai Taishi, Ominami Masaki, Sugimori Satoshi, Otani Koji, Hosomi Shuhei, Tanaka Fumio, Taira Koichi, Kamata Noriko, Yamagami Hirokazu, Tanigawa Tetsuya, Shiba Masatsugu, Watanabe Toshio, Fujiwara Yasuhiro

    GASTROINTESTINAL ENDOSCOPY   87 ( 6 )   AB399 - AB399   2018.06( ISSN:0016-5107

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  • Lymph Node Metastasis of Mixed Adenoneuroendocrine Carcinoma after Curative Resection Using the Expanded Criteria for Early Gastric Cancer. Reviewed

    Ochiai T, Ominami M, Nagami Y, Fukunaga S, Toyokawa T, Yamagami H, Tanigawa T, Watanabe T, Ohira M, Ohsawa M, Fujiwara Y

    一般社団法人 日本内科学会 Internal medicine (Tokyo, Japan)   2018.05( ISSN:0918-2918

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    <p>Endoscopic submucosal dissection (ESD) of lesions using expanded indications for early gastric cancer (EGC) has been accepted as an alternative treatment for cases without lymph node metastasis. We herein report a rare case of metastatic lymph node tissue in mixed adenoneuroendocrine carcinoma (MANEC) after curative ESD using the expanded pathological criteria. A 70-year-old man underwent ESD for two EGC lesions. A pathological examination revealed lesions that required curative resection based on the expanded pathological criteria of the Japanese classification of gastric carcinoma. However, lymph node metastasis was detected at 26 months after ESD. Additional surgical resection was performed and MANEC was pathologically diagnosed in the metastatic lymph node. The patient subsequently underwent additional chemotherapy and remains alive at 2 years after surgery. Even though MANEC is a rare tumor, this case suggests that periodic follow-up is important when patients undergo curative resection by ESD based on the expanded indications because of the high malignant potential and the poor prognosis. </p>

    DOI: 10.2169/internalmedicine.0311-17

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  • Use of a Laparoscopic Bag for the Endoscopic Retrieval of a Large Gastric Tumor After Endoscopic Submucosal Dissection Reviewed

    Nagami Yasuaki, Ominami Masaki, Sawada Akinari, Sakai Taishi, Fukunaga Shusei, Watanabe Toshio, Fujiwara Yasuhiro

    AMERICAN JOURNAL OF GASTROENTEROLOGY   113 ( 4 )   463 - 463   2018.04( ISSN:0002-9270

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    DOI: 10.1038/ajg.2018.31

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  • Efficacy of a concomitant elemental diet to reduce the loss of response to adalimumab in patients with intractable Crohn's disease. Reviewed

    Sugita N, Watanabe K, Kamata N, Yukawa T, Otani K, Hosomi S, Nagami Y, Tanaka F, Taira K, Yamagami H, Tanigawa T, Shiba M, Watanabe T, Tominaga K, Kabata D, Shintani A, Arakawa T, Fujiwara

    J Gastroenterol Hepatol.   2018.03

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  • Comparison of propofol with midazolam in endoscopic submucosal dissection for esophageal squamous cell carcinoma: a randomized controlled trial Reviewed

    Ominami Masaki, Nagami Yasuaki, Shiba Masatsugu, Tominaga Kazunari, Sakai Taishi, Maruyama Hirotsugu, Kato Kunihiro, Minamino Hiroaki, Fukunaga Shusei, Tanaka Fumio, Sugimori Satoshi, Kamata Noriko, Machida Hirohisa, Yamagami Hirokazu, Tanigawa Tetsuya, Watanabe Toshio, Fujiwara Yasuhiro, Arakawa Tetsuo

    JOURNAL OF GASTROENTEROLOGY   53 ( 3 )   397 - 406   2018.03( ISSN:0944-1174

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    DOI: 10.1007/s00535-017-1358-6

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  • Prediction of esophageal stricture in patients given locoregional triamcinolone injections immediately after endoscopic submucosal dissection Reviewed

    Nagami Yasuaki, Ominami Masaki, Shiba Masatsugu, Sakai Taishi, Fukunaga Shusei, Sugimori Satoshi, Otani Koji, Hosomi Shuhei, Tanaka Fumio, Taira Koichi, Kamata Noriko, Yamagami Hirokazu, Tanigawa Tetsuya, Watanabe Toshio, Ishihara Takuma, Yamamoto Kouji, Fujiwara Yasuhiro

    DIGESTIVE ENDOSCOPY   30 ( 2 )   198 - 205   2018.03( ISSN:0915-5635

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    DOI: 10.1111/den.12946

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  • Serum interleukin-6 level predicts future outcomes of infliximab for ulcerative colitis Reviewed

    Nishida Y., Hosomi S., Yukawa T., Otani K., Nagami Y., Tanaka F., Taira K., Kamata N., Yamagami H., Tanigawa T., Watanabe T., Fujiwara Y.

    JOURNAL OF CROHNS & COLITIS   12   S482 - S482   2018.02( ISSN:1873-9946

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  • A comparison of thiopurines vs. anti-TNF-alpha therapy in steroid-dependent ulcerative colitis Reviewed

    Hosomi S., Ohira M., Yamagami H., Nakata R., Sugita N., Nishida Y., Itani S., Yukawa T., Kamata N., Otani K., Nagami Y., Tanaka F., Taira K., Tanigawa T., Watanabe T., Fujiwara Y.

    JOURNAL OF CROHNS & COLITIS   12   S341 - S341   2018.02( ISSN:1873-9946

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  • Risk of pancreatitis after pancreatic duct guidewire placement during endoscopic retrograde cholangiopancreatography Reviewed

    Ishikawa-Kakiya Yuki, Shiba Masatsugu, Maruyama Hirotsugu, Kato Kunihiro, Fukunaga Shusei, Sugimori Satoshi, Otani Koji, Hosomi Shuhei, Tanaka Fumio, Nagami Yasuaki, Taira Koichi, Yamagami Hirokazu, Tanigawa Tetsuya, Watanabe Toshio, Fujiwara Yasuhiro

    PLOS ONE   13 ( 1 )   e0190379   2018.01( ISSN:1932-6203

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    DOI: 10.1371/journal.pone.0190379

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  • Isoliquiritigenin Ameliorates Indomethacin-Induced Small Intestinal Damage by Inhibiting NOD-Like Receptor Family, Pyrin Domain-Containing 3 Inflammasome Activation. Reviewed

    Nakamura S, Watanabe T, Tanigawa T, Shimada S, Nadatani Y, Miyazaki T, Iimuro M, Fujiwara Y

    Pharmacology.   2018.01

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  • Sepsis Markers Soluble IL-2 Receptor and Soluble CD14 Subtype as Potential Biomarkers for Complete Mucosal Healing in Patients With Inflammatory Bowel Disease. Reviewed

    Hosomi S, Yamagami H, Itani S, Yukawa T, Otani K, Nagami Y, Tanaka F, Taira K, Kamata N, Tanigawa T, Shiba M, Watanabe T, Fujiwara Y.

    J Crohns Colitis.   2018.01

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  • A Metastatic Gastric Tumor from Ovarian Cancer Reviewed

    Kono Mitsuhiro, Nagami Yasuaki, Ominami Masaki, Sakai Taishi, Fukuda Takeshi, Fukunaga Shusei, Tanaka Fumio, Sugimori Satoshi, Yamagami Hirokazu, Tanigawa Tetsuya, Shiba Masatsugu, Tominaga Kazunari, Watanabe Toshio, Fujiwara Yasuhiro, Arakawa Tetsuo

    一般社団法人 日本内科学会 INTERNAL MEDICINE   57 ( 3 )   345 - 349   2018( ISSN:0918-2918

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    <p>Gastric metastasis from ovarian cancer has rarely been reported. We herein report the case of a 64-year-old woman with gastric metastasis from ovarian cancer that was diagnosed as surgical stage IA. Diagnostic and staging laparotomy showed mucinous carcinoma of the right ovary. At one month after surgery, bone metastasis was detected via scintigraphy. On esophagogastroduodenoscopy, a 10-mm elevated lesion with ulceration on the top was seen in the stomach. The immunohistochemical analysis of biopsy specimens showed that these metastases arose from ovarian cancer. We recommend that physicians remain aware of the possibility of gastric metastasis in patients with ovarian cancer. </p>

    DOI: 10.2169/internalmedicine.9147-17

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  • A CASE OF MULTIPLE SUPERFICIAL ESOPHAGEAL CANCERS ASSOCIATED WITH ACHALASIA OF THE ESOPHAGUS TREATED BY ENDOSCOPIC SUBMUCOSAL DISSECTION Reviewed

    MARUYAMA Hirotsugu, TOMINAGA Kazunari, SAKAI Taishi, OMINAMI Masaki, NAGAMI Yasuaki, SUGIMORI Satoshi, SHIBA Masatsugu, WATANABE Toshio, FUJIWARA Yasuhiro, ARAKAWA Tetsuo

    Japan Gastroenterological Endoscopy Society, GASTROENTEROLOGICAL ENDOSCOPY   60 ( 5 )   1076 - 1082   2018

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    <p>We performed endoscopic submucosal dissection (ESD) for multiple superficial esophageal cancers in a case coexisting with esophageal achalasia. The patient was a 55-year-old man who suffered from dysphagia for the past 18 years. He was diagnosed as having esophageal achalasia by various imaging examinations that revealed the morphology and function of the esophagus. Then, screening esophagogastroduodenoscopy detected multiple superficial esophageal cancers at the upper part (1 lesion) and the middle part (5 lesions) of the esophagus. All esophageal lesions at the upper and middle parts of the esophagus in the patient who had already been diagnosed with esophageal achalasia, were successfully removed by ESD. Pathological examination showed squamous cell carcinoma for three lesions and high-grade intraepithelial neoplasia for the other three lesions. Immunostaining for p53 showed positivity in not only cancer cells but also non-cancerous cells. In this case, it is likely that prolonged mechanical and chemical irritations due to achalasia led to a p53 mutation and resulted in the development of cancer. It is important to carry out careful long-term follow-up for patients with achalasia to detect esophageal cancer as soon as possible. We herein report such a patient with a review of the relevant literature.</p>

    DOI: 10.11280/gee.60.1076

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  • Serum interleukin-6 level is associated with response to infliximab in ulcerative colitis Reviewed

    Nishida Yu, Hosomi Shuhei, Watanabe Kenji, Watanabe Kimihiko, Yukawa Tomomi, Otani Koji, Nagami Yasuaki, Tanaka Fumio, Taira Koichi, Kamata Noriko, Yamagami Hirokazu, Tanigawa Tetsuya, Watanabe Toshio, Fujiwara Yasuhiro

    SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY   53 ( 5 )   579 - 585   2018( ISSN:0036-5521

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    DOI: 10.1080/00365521.2017.1403647

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  • Questionnaire-Based Survey on Gastrointestinal Bleeding and Management of Antithrombotic Agents during Endoscopy Among Asian Countries Reviewed

    Tsuruoka Nanae, Iwakiri Ryuichi, Sakata Yasuhisa, Fujimoto Kazuma, Kamiya Takeshi, Joh Takashi, Tokunaga Kengo, Takahashi Shin'ichi, Kinoshita Yoshikazu, Uchiyama Kazuhiko, Naito Yuji, Nagahara Akihito, Watanabe Toshio, Chan Francis K. L., Hahm Ki-Baik, Kachintorn Udom, Fock Kwong Ming, Syam Ari Fahrial, Rani Abdul Aziz, Sollano Jose D., Zhu Qi

    DIGESTION   97 ( 1 )   97 - 106   2018( ISSN:0012-2823

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    DOI: 10.1159/000484228

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  • Endoscopic Submucosal Dissection for Adenocarcinomas of the Esophagogastric Junction Reviewed

    Nagami Yasuaki, Ominami Masaki, Otani Koji, Hosomi Shuhei, Tanaka Fumio, Taira Koichi, Kamata Noriko, Yamagami Hirokazu, Tanigawa Tetsuya, Shiba Masatsugu, Watanabe Toshio, Fujiwara Yasuhiro

    DIGESTION   97 ( 1 )   38 - 44   2018( ISSN:0012-2823

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    DOI: 10.1159/000484111

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  • Does discontinuation of antithrombotics affect the diagnostic yield of small bowel capsule endoscopy in patients demonstrating obscure gastrointestinal bleeding? Reviewed

    Nakamura Shiro, Watanabe Toshio, Shimada Sunao, Nadatani Yuji, Otani Koji, Tanigawa Tetsuya, Miyazaki Takako, Iimuro Masaki, Fujiwara Yasuhiro

    日本酸化ストレス学会 Journal of Clinical Biochemistry and Nutrition   2018

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    <p>A large proportion of patients demonstrating obscure gastrointestinal bleeding (OGIB) are antithrombotic users and need to undergo small bowel capsule endoscopy (SBCE). We examined the effect of discontinuation of antithrombotics on the diagnostic yield of SBCE. Additionally, we assessed predictive factors associated with positive SBCE findings. Our study included 130 patients using antithrombotics who underwent SBCE for overt OGIB. The primary endpoint was the difference in the rate of positive SBCE findings between patients who continued and those who discontinued antithrombotics. Secondary endpoints were to investigate the effect of discontinuation of antithrombotics using a propensity score analysis, and to assess predictive factors associated with a positive SBCE. Among the 73 patients who continued use of antithrombotics, 36 (49.3%) patients demonstrated positive findings, while among the 57 patients who discontinued antithrombotics, 35 (61.4%) patients showed positive findings. Rates of positive SBCE findings didn't differ between the two groups. After we performed propensity score matching, discontinuation didn't affect the rate of positive SBCE findings. The lowest hemoglobin level was the only independent predictive factor associated with positive SBCE findings. In conclusion, discontinuation of antithrombotic therapy didn't affect the diagnostic yield of SBCE in patients presenting with overt OGIB.</p>

    DOI: 10.3164/jcbn.17-142

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  • Clinical Utility of Capsule Endoscopy and Double-Balloon Enteroscopy in the Management of Obscure Gastrointestinal Bleeding Reviewed

    Otani Koji, Watanabe Toshio, Shimada Sunao, Hosomi Shuhei, Nagami Yasuaki, Tanaka Fumio, Kamata Noriko, Taira Koichi, Yamagami Hirokazu, Tanigawa Tetsuya, Shiba Masatsugu, Fujiwara Yasuhiro

    DIGESTION   97 ( 1 )   52 - 58   2018( ISSN:0012-2823

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    DOI: 10.1159/000484218

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  • Safety and efficacy of transpapillary bridged bilateral side-by-side stenting for unresectable malignant hilar biliary obstruction Reviewed

    Maruyama Hirotsugu, Tominaga Kazunari, Kato Kunihiro, Sugimori Satoshi, Shiba Masatsugu, Watanabe Toshio, Fujiwara Yasuhiro

    HEPATOBILIARY & PANCREATIC DISEASES INTERNATIONAL   16 ( 6 )   659 - 661   2017.12( ISSN:1499-3872

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    DOI: 10.1016/S1499-3872(17)60072-9

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  • Serum interleukin-6 level is associated with response to infliximab in ulcerative colitis. Reviewed

    Nishida Y, Hosomi S, Watanabe K, Watanabe K, Yukawa T, Otani K, Nagami Y, Tanaka F, Taira K, Kamata N, Yamagami H, Tanigawa T, Watanabe T, Fujiwara Y

    Scand J Gastroenterol.   2017.11

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  • Brushing the distal biliary stricture in the surrounding of the papilla increased the risk of post-endoscopic retrograde cholangiopancreatography pancreatitis: A retrospective study using propensity score analysis Reviewed

    Kato Kunihiro, Sugimori Satoshi, Kakiya Yuki, Maruyama Hirotsugu, Fukunaga Shusei, Nagami Yasuaki, Shiba Masatsugu, Tanigawa Tetsuya, Watanabe Toshio, Fujiwara Yasuhiro

    UNITED EUROPEAN GASTROENTEROLOGY JOURNAL   5 ( 7 )   1015 - 1023   2017.11( ISSN:2050-6406

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    DOI: 10.1177/2050640617694279

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  • Distal esophageal spasm with multiple esophageal diverticula successfully treated by peroral endoscopic myotomy Reviewed

    Otani Koji, Tanaka Shinwa, Kawara Fumiaki, Fujikawa Junichi, Sawada Akinari, Uemura Risa, Tanigawa Tetsuya, Watanabe Toshio, Azuma Takeshi, Fujiwara Yasuhiro

    CLINICAL JOURNAL OF GASTROENTEROLOGY   10 ( 5 )   442 - 446   2017.10( ISSN:1865-7257

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    DOI: 10.1007/s12328-017-0768-6

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  • A comparison of short-term therapeutic efficacy between infliximab and tacrolimus for moderate to severe ulcerative colitis Reviewed

    Yamagami Hirokazu, Nishida Yu, Nagami Yasuaki, Hosomi Shuhei, Yukawa Tomomi, Otani Koji, Tanaka Fumio, Taira Koichi, Kamata Noriko, Tanigawa Tetsuya, Shiba Masatsugu, Watanabe Toshio, Fujiwara Yasuhiro

    ROMANIAN JOURNAL OF INTERNAL MEDICINE   55 ( 3 )   151 - 157   2017.09( ISSN:1582-3296

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    DOI: 10.1515/rjim-2017-0012

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  • Celecoxib Oral Administration for Prevention of Post-Endoscopic Retrograde Cholangiopancreatography Pancreatitis A Randomized Prospective Trial Reviewed

    Kato Kunihiro, Shiba Masatsugu, Kakiya Yuki, Maruyama Hirotsugu, Ominami Masaki, Fukunaga Shusei, Sugimori Satoshi, Nagami Yasuaki, Watanabe Toshio, Tominaga Kazunari, Fujiwara Yasuhiro

    PANCREAS   46 ( 7 )   880 - 886   2017.08( ISSN:0885-3177

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    DOI: 10.1097/MPA.0000000000000852

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  • Expression of Serum Exosomal and Esophageal MicroRNA in Rat Reflux Esophagitis Reviewed

    Uemura Risa, Murakami Yoshiki, Hashimoto Atsushi, Sawada Akinari, Otani Koji, Taira Koichi, Hosomi Shuhei, Nagami Yasuaki, Tanaka Fumio, Kamata Noriko, Yamagami Hirokazu, Tanigawa Tetsuya, Watanabe Toshio, Taguchi Y-h, Fujiwara Yasuhiro

    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES   18 ( 8 )   2017.08( ISSN:1422-0067

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    DOI: 10.3390/ijms18081611

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  • The Predictive Factor for Esophageal Stricture in Patients Who Received Locoregional Triamcinolone Injection Immediately After ESD Reviewed

    Nagami Yasuaki, Ominami Masaki, Shiba Masatsugu, Sakai Taishi, Fukunaga Shusei, Sugimori Satoshi, Otani Koji, Hosomi Shuhei, Tanaka Fumio, Kamata Noriko, Yamagami Hirokazu, Tanigawa Tetsuya, Watanabe Toshio, Fujiwara Yasuhiro

    GASTROINTESTINAL ENDOSCOPY   85 ( 5 )   AB577 - AB577   2017.05( ISSN:0016-5107

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  • Does Discontinuation of Antithrombotic Agents Affect Diagnostic Yield of Small Bowel Capsule Endoscopy in Patients With Obscure Gastrointestinal Bleeding? Reviewed

    Watanabe Toshio, Shimada Sunao, Nadatani Yuji, Otani Koji, Tanaka Fumio, Nagami Yasuaki, Kamata Noriko, Yamagami Hirokazu, Tanigawa Tetsuya, Shiba Masatsugu, Miyazaki Takako, Nakamura Shiro, Fujiwara Yasuhiro

    GASTROINTESTINAL ENDOSCOPY   85 ( 5 )   AB293 - AB294   2017.05( ISSN:0016-5107

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  • Long-Term Outcome of Endoscopic Submucosal Dissection for Early Gastric Cancer in Patients With Severe Comorbidities: A Comparative Propensity Score Analysis Reviewed

    Tanoue Koujiro, Fukunaga Shusei, Nagami Yasuaki, Nakamura Yoshihiro, Kakiya Yuki, Hayashi Kappei, Kinoshita Yosuke, Sakai Taishi, Maruyama Hirotsugu, Kato Kunihiro, Ominami Masaki, Sugimori Satoshi, Otani Koji, Hosomi Shuhei, Tanaka Fumio, Taira Koichi, Kamata Noriko, Yamagami Hirokazu, Tanigawa Tetsuya, Shiba Masatsugu, Watanabe Toshio, Fujiwara Yasuhiro

    GASTROINTESTINAL ENDOSCOPY   85 ( 5 )   AB429 - AB430   2017.05( ISSN:0016-5107

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  • The Predictive Factor for Esophageal Stricture in Patients Who Received Locoregional Triamcinolone Injection Immediately After ESD Reviewed

    Nagami Yasuaki, Ominami Masaki, Shiba Masatsugu, Sakai Taishi, Fukunaga Shusei, Sugimori Satoshi, Otani Koji, Hosomi Shuhei, Tanaka Fumio, Kamata Noriko, Yamagami Hirokazu, Tanigawa Tetsuya, Watanabe Toshio, Fujiwara Yasuhiro

    GASTROINTESTINAL ENDOSCOPY   85 ( 5 )   AB577 - AB577   2017.05( ISSN:0016-5107

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  • The five-year survival rate after endoscopic submucosal dissection for superficial esophageal squamous cell neoplasia Reviewed

    Nagami Yasuaki, Ominami Masaki, Shiba Masatsugu, Minamino Hiroaki, Fukunaga Shusei, Kameda Natsuhiko, Sugimori Satoshi, Machida Hirohisa, Tanigawa Tetsuya, Yamagami Hirokazu, Watanabe Toshio, Tominaga Kazunari, Fujiwara Yasuhiro, Arakawa Tetsuo

    DIGESTIVE AND LIVER DISEASE   49 ( 4 )   427 - 433   2017.04( ISSN:1590-8658

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    DOI: 10.1016/j.dld.2016.12.009

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  • Neutrophil-to-lymphocyte ration in ulcerative colitis predicts sustained response to infliximab Reviewed

    Nishida Y., Hosomi S., Watanabe K., Yukawa T., Otani K., Nagami Y., Tanaka F., Taira K., Kamata N., Shiba M., Yamagami H., Tanigawa T., Watanabe T., Tominaga K., Fujiwara Y.

    JOURNAL OF CROHNS & COLITIS   11   S294 - S294   2017.02( ISSN:1873-9946

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  • Single Locoregional Triamcinolone Injection Immediately After Esophageal Endoscopic Submucosal Dissection Prevents Stricture Formation Reviewed

    Nagami Yasuaki, Shiba Masatsugu, Ominami Masaki, Sakai Taishi, Minamino Hiroaki, Fukunaga Shusei, Sugimori Satoshi, Tanaka Fumio, Kamata Noriko, Tanigawa Tetsuya, Yamagami Hirokazu, Watanabe Toshio, Tominaga Kazunari, Fujiwara Yasuhiro, Arakawa Tetsuo

    CLINICAL AND TRANSLATIONAL GASTROENTEROLOGY   8 ( 2 )   e75   2017.02( ISSN:2155-384X

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    DOI: 10.1038/ctg.2017.5

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  • Neutrophil-to-Lymphocyte Ratio for Predicting Loss of Response to Infliximab in Ulcerative Colitis Reviewed

    Nishida Yu, Hosomi Shuhei, Yamagami Hirokazu, Yukawa Tomomi, Otani Koji, Nagami Yasuaki, Tanaka Fumio, Taira Koichi, Kamata Noriko, Tanigawa Tetsuya, Shiba Masatsugu, Watanabe Kenji, Watanabe Toshio, Tominaga Kazunari, Fujiwara Yasuhiro

    PLOS ONE   12 ( 1 )   e0169845   2017.01( ISSN:1932-6203

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    DOI: 10.1371/journal.pone.0169845

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  • Similar Efficacy of Proton-Pump Inhibitors vs H2-Receptor Antagonists in Reducing Risk of Upper Gastrointestinal Bleeding or Ulcers in High-Risk Users of Low-Dose Aspirin Reviewed

    Chan Francis K. L., Kyaw Moe, Tanigawa Tetsuya, Higuchi Kazuhide, Fujimoto Kazuma, Cheong Pui Kuan, Lee Vivian, Kinoshita Yoshikazu, Naito Yuji, Watanabe Toshio, Ching Jessica Y. L., Lam Kelvin, Lo Angeline, Chan Heyson, Lui Rashid, Tang S. Y., Sakata Yasuhisa, Tse Yee Kit, Takeuchi Toshihisa, Handa Osamu, Nebiki Hiroko, Wu Justin C. Y., Abe Takashi, Mishiro Tsuyoshi, Ng Siew C., Arakawa Tetsuo

    GASTROENTEROLOGY   152 ( 1 )   105 - +   2017.01( ISSN:0016-5085

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    DOI: 10.1053/j.gastro.2016.09.006

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  • Long-term prognosis of expanded-indication differentiated-type early gastric cancer treated with endoscopic submucosal dissection or surgery using propensity score analysis Reviewed

    Fukunaga Shusei, Nagami Yasuaki, Shiba Masatsugu, Ominami Masaki, Tanigawa Tetsuya, Yamagami Hirokazu, Tanaka Hiroaki, Muguruma Kazuya, Watanabe Toshio, Tominaga Kazunari, Fujiwara Yasuhiro, Ohira Masaichi, Hirakawa Kosei, Arakawa Tetsuo

    GASTROINTESTINAL ENDOSCOPY   85 ( 1 )   143 - 152   2017.01( ISSN:0016-5107

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    DOI: 10.1016/j.gie.2016.06.049

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  • A comparison between capsule endoscopy and double balloon enteroscopy using propensity score-matching analysis in patients with previous obscure gastrointestinal bleeding Reviewed

    Kakiya Yuki, Shiba Masatsugu, Okamoto Junichi, Kato Kunihiro, Minamino Hiroaki, Ominami Masaki, Fukunaga Shusei, Nagami Yasuaki, Sugimori Satoshi, Tanigawa Tetsuya, Yamagami Hirokazu, Watanabe Toshio, Tominaga Kazunari, Fujiwara Yasuhiro, Arakawa Tetsuo

    SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY   52 ( 3 )   306 - 311   2017( ISSN:0036-5521

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    DOI: 10.1080/00365521.2016.1253766

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  • Postprandial Symptoms Felt at the Lower Part of the Epigastrium and a Possible Association of Pancreatic Exocrine Dysfunction with the Pathogenesis of Functional Dyspepsia Reviewed

    Fujikawa Yoshiko, Tominaga Kazunari, Tanaka Fumio, Kamata Noriko, Yamagami Hirokazu, Tanigawa Tetsuya, Watanabe Toshio, Fujiwara Yasuhiro, Arakawa Tetsuo

    一般社団法人 日本内科学会 INTERNAL MEDICINE   56 ( 13 )   1629 - 1635   2017( ISSN:0918-2918

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    <p><b>Objective </b>In symptom-dependent diseases such as functional dyspepsia (FD), matching the pattern of epigastric symptoms, including severity, kind, and perception site, between patients and physicians is critical. Additionally, a comprehensive examination of the stomach, duodenum, and pancreas is important for evaluating the origin of such symptoms. </p><p><b>Methods </b>FD-specific symptoms (epigastric pain, epigastric burning, early satiety, and postprandial fullness) and other symptoms (regurgitation, nausea, belching, and abdominal bloating) as well as the perception site of the above symptoms were investigated in healthy subjects using a new questionnaire with an illustration of the human body. A total of 114 patients with treatment-resistant dyspeptic symptoms were evaluated for their pancreatic exocrine function using N-benzoyl-L-tyrosyl-p-aminobenzoic acid. </p><p><b>Results </b>A total of 323 subjects (men:women, 216:107; mean age, 52.1 years old) were initially enrolled. Most of the subjects felt the FD-specific symptoms at the epigastrium, while about 20% felt them at other abdominal sites. About 30% of expressed as epigastric symptoms were FD-nonspecific symptoms. At the epigastrium, epigastric pain and epigastric burning were mainly felt at the upper part, and postprandial fullness and early satiety were felt at the lower part. The prevalence of patients with pancreatic exocrine dysfunction was 71% in the postprandial fullness group, 68% in the epigastric pain group, and 82% in the diarrhea group. </p><p><b>Conclusion </b>We observed mismatch in the perception site and expression between the epigastric symptoms of healthy subjects and FD-specific symptoms. Postprandial symptoms were often felt at the lower part of the epigastrium, and pancreatic exocrine dysfunction may be involved in the FD symptoms, especially for treatment-resistant dyspepsia patients. </p>

    DOI: 10.2169/internalmedicine.56.8193

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  • Present issues and measures for NSAID-induced small intestinal damage Reviewed

    Otani Koji, Watanabe Toshio, Fujiwara Yasuhiro

    The Japanese Society for Clinical Rheumatology and Related Research, Clinical Rheumatology and Related Research   29 ( 2 )   77 - 84   2017

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    <p>&nbsp;&nbsp;&nbsp;&nbsp;Non-steroidal anti-inflammatory drugs (NSAIDs) are currently the drugs most frequently used for osteoarthritis and rheumatoid arthritis (RA). It has become a major problem that NSAIDs damage the mucosa of the upper gastrointestinal tract and eventually cause gastric and duodenal ulcer. Moreover, recent studies using video capsule endoscopy and balloon-assisted enteroscopy have clarified that NSAIDs frequently damage the mucosa of small intestine. Although selective COX-2 inhibitors prevent NSAID-induced small intestinal damage in short-term use, it has been shown that the preventive effect is eliminated in long-term use. The use of disease-modifying anti-rheumatic drugs with NSAIDs is considered to aggravate the small intestinal damage. On the other hand, it has been proven that RA patients who receive anti-TNF-α therapy have less severe NSAID-induced small intestinal damage than those who does not receive the therapy. It is clinically significant that proton pump inhibitors (PPIs) cannot protect the small intestine from NSAIDs as hydrochloric acid is not produced in the small intestine. Moreover, some studies have raised the possibility that PPIs might exacerbate the small intestinal damage. Although mucoprotective drug and prostaglandin analogue are expected to be effective for NSAID-induced small intestinal damage at the present, we consider that anti-TNF-α therapy, probiotics, and colchicine could be new candidates for therapeutic agents for the damage. Thus, therapeutic strategies for NSAID-induced gastrointestinal damage need to be established based on these new findings.</p>

    DOI: 10.14961/cra.29.77

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  • Microbiota Plays a Key Role in Non-Steroidal Anti-Inflammatory Drug-Induced Small Intestinal Damage Reviewed

    Otani Koji, Tanigawa Tetsuya, Watanabe Toshio, Shimada Sunao, Nadatani Yuji, Nagami Yasuaki, Tanaka Fumio, Kamata Noriko, Yamagami Hirokazu, Shiba Masatsugu, Tominaga Kazunari, Fujiwara Yasuhiro, Arakawa Tetsuo

    DIGESTION   95 ( 1 )   22 - 28   2017( ISSN:0012-2823

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    DOI: 10.1159/000452356

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  • Clinical factors associated with positive capsule endoscopy findings in patients with obscure gastrointestinal bleeding: a single-center study Reviewed

    Shimada Sunao, Watanabe Toshio, Nadatani Yuji, Otani Koji, Taira Koichi, Hosomi Shuhei, Nagami Yasuaki, Tanaka Fumio, Kamata Noriko, Yamagami Hirokazu, Tanigawa Tetsuya, Shiba Masatsugu, Fujiwara Yasuhiro

    SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY   52 ( 11 )   1219 - 1223   2017( ISSN:0036-5521

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    DOI: 10.1080/00365521.2017.1349174

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  • Analysis of the Risk Factors of Surgery after Endoscopic Balloon Dilation for Small Intestinal Strictures in Crohn's Disease Using Double-balloon Endoscopy Reviewed

    Nishida Yu, Hosomi Shuhei, Yamagami Hirokazu, Yukawa Tomomi, Nagami Yasuaki, Tanaka Fumio, Kamata Noriko, Tanigawa Tetsuya, Shiba Masatsugu, Watanabe Toshio, Tominaga Kazunari, Fujiwara Yasuhiro, Arakawa Tetsuo

    一般社団法人 日本内科学会 INTERNAL MEDICINE   56 ( 17 )   2245 - 2252   2017( ISSN:0918-2918

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    <p><b>Objective </b>Balloon-assisted endoscopy enables access to and treatment of strictures in the small intestine using endoscopic balloon dilation (EBD); however, the long-term outcomes of EBD have not been sufficiently evaluated. This study evaluated the long-term outcomes of EBD in Crohn's disease to identify the risk factors associated with the need for subsequent surgical intervention. </p><p><b>Methods </b>We retrospectively analyzed patients with Crohn's disease who had undergone EBD with double-balloon endoscopy (DBE) for small intestinal strictures at a single center between 2006 and 2015. The long-term outcomes were assessed based on the cumulative surgery-free rate following initial EBD. </p><p><b>Results </b>Seventy-two EBD with DBE sessions and 112 procedures were performed for 37 patients during this period. Eighteen patients (48.6%) required surgery during follow-up. Significant factors associated with the need for surgery in a multivariate analysis were multiple strictures (adjusted hazard ratio, 14.94; 95% confidence interval, 1.91-117.12; p=0.010). One patient (6.7%) required surgery among 15 who had single strictures compared to 17 (77.3%) among 22 patients with multiple strictures. </p><p><b>Conclusion </b>In a multivariate analysis, the presence of multiple strictures was a significant risk factor associated with the need for surgery; therefore, a single stricture might be a good indication for EBD using DBE for small intestinal strictures in Crohn's disease patients. </p>

    DOI: 10.2169/internalmedicine.8224-16

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  • NLRP3 inflammasome has a protective effect against oxazolone-induced colitis: a possible role in ulcerative colitis Reviewed

    Itani Shigehiro, Watanabe Toshio, Nadatani Yuji, Sugimura Naoki, Shimada Sunao, Takeda Shogo, Otani Koji, Hosomi Shuhei, Nagami Yasuaki, Tanaka Fumio, Kamata Noriko, Yamagami Hirokazu, Tanigawa Tetsuya, Shiba Masatsugu, Tominaga Kazunari, Fujiwara Yasuhiro, Arakawa Tetsuo

    SCIENTIFIC REPORTS   6   39075   2016.12( ISSN:2045-2322

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    DOI: 10.1038/srep39075

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  • Concentration of Glial Cell Line-Derived Neurotrophic Factor Positively Correlates with Symptoms in Functional Dyspepsia Reviewed

    Tanaka Fumio, Tominaga Kazunari, Fujikawa Yoshiko, Nagami Yasuaki, Kamata Noriko, Yamagami Hirokazu, Tanigawa Tetsuya, Shiba Masatsugu, Watanabe Toshio, Fujiwara Yasuhiro, Arakawa Tetsuo

    DIGESTIVE DISEASES AND SCIENCES   61 ( 12 )   3478 - 3485   2016.12( ISSN:0163-2116

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    DOI: 10.1007/s10620-016-4329-5

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  • Roles of NLRP3 inflammasome in the pathogenesis of Th2-mediated colitis Reviewed

    Itani Shigehiro, Watanabe Toshio, Nadatani Yuji, Sugimura Naoki, Hosomi Shuhei, Yamagami Hirokazu, Tanigawa Tetsuya, Tominaga Kazunari, Fujiwara Yasuhiro, Arakawa Tetsuo

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   31   150 - 150   2016.11( ISSN:0815-9319

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  • Lithotomy is associated with moderate to severe post-endoscopic retrograde cholangiopancreatography pancreatitis using inverse probability of treatment weighting Reviewed

    Sugimori Satoshi, Shiba Masatsugu, Maruyama Hirotsugu, Kato Kunihiro, Nagami Yasuaki, Tanigawa Tetsuya, Watanabe Toshio, Tominaga Kazunari, Fujiwara Yasuhiro

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   31   249 - 249   2016.11( ISSN:0815-9319

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  • Inflammasome has an aggravating effect against gastric ulcer healing Reviewed

    Nadatani Yuji, Watanabe Toshio, Sugimura Naoki, Shimada Sunao, Otani Koji, Yamagami Hirokazu, Tanigawa Tetsuya, Tominaga Kazunari, Fujiwara Yasuhiro, Arakawa Tetsuo

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   31   59 - 59   2016.11( ISSN:0815-9319

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  • Alteration of Esophageal Microbiome by Antibiotic Treatment Does Not Affect Incidence of Rat Esophageal Adenocarcinoma Reviewed

    Sawada Akinari, Fujiwara Yasuhiro, Nagami Yasuaki, Tanaka Fumio, Yamagami Hirokazu, Tanigawa Tetsuya, Shiba Masatsugu, Tominaga Kazunari, Watanabe Toshio, Gi Min, Wanibuchi Hideki, Arakawa Tetsuo

    DIGESTIVE DISEASES AND SCIENCES   61 ( 11 )   3161 - 3168   2016.11( ISSN:0163-2116

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    DOI: 10.1007/s10620-016-4263-6

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  • Colchicine has preventive effect on nonsteroidal anti-inflammatory drug-induced small intestinal damage Reviewed

    Otani Koji, Watanabe Toshio, Sugimura Naoki, Shimada Sunao, Itani Shigehiro, Higashimori Akira, Nadatani Yuji, Tanigawa Tetsuya, Tominaga Kazunari, Fujiwara Yasuhiro

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   31   125 - 125   2016.11( ISSN:0815-9319

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  • Sleep disturbances in Japanese patients with inflammatory bowel disease and their impact on disease flare Reviewed

    Uemura Risa, Fujiwara Yasuhiro, Iwakura Narika, Shiba Masatsugu, Watanabe Kenji, Kamata Noriko, Yamagami Hirokazu, Tanigawa Tetsuya, Watanabe Toshio, Tominaga Kazunari, Arakawa Tetsuo

    SPRINGERPLUS   5 ( 1 )   1792   2016.10( ISSN:2193-1801

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    DOI: 10.1186/s40064-016-3408-6

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  • Double-balloon endoscopy WAS effective in diagnosing small intestinal duplication: a case report Reviewed

    Nadatani Yuji, Watanabe Toshio, Sugawa Takashi, Eguchi Shinpei, Shimada Sunao, Otani Koji, Yamagami Hirokazu, Tanigawa Tetsuya, Shiba Masatsugu, Tominaga Kazunari, Fujiwara Yasuhiro, Arakawa Tetsuo

    SPRINGERPLUS   5 ( 1 )   1598   2016.09( ISSN:2193-1801

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    DOI: 10.1186/s40064-016-3256-4

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  • Colchicine prevents NSAID-induced small intestinal injury by inhibiting activation of the NLRP3 inflammasome Reviewed

    Otani Koji, Watanabe Toshio, Shimada Sunao, Takeda Shogo, Itani Shigehiro, Higashimori Akira, Nadatani Yuji, Nagami Yasuaki, Tanaka Fumio, Kamata Noriko, Yamagami Hirokazu, Tanigawa Tetsuya, Shiba Masatsugu, Tominaga Kazunari, Fujiwara Yasuhiro, Arakawa Tetsuo

    SCIENTIFIC REPORTS   6   32587   2016.09( ISSN:2045-2322

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    DOI: 10.1038/srep32587

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  • Hybrid therapy with locoregional steroid injection and polyglycolic acid sheets to prevent stricture after esophageal endoscopic submucosal dissection Reviewed

    Nagami Yasuaki, Shiba Masatsugu, Tominaga Kazunari, Ominami Masaki, Fukunaga Shusei, Sugimori Satoshi, Tanaka Fumio, Kamata Noriko, Tanigawa Tetsuya, Yamagami Hirokazu, Watanabe Toshio, Fujiwara Yasuhiro, Arakawa Tetsuo

    ENDOSCOPY INTERNATIONAL OPEN   4 ( 9 )   E1017 - E1022   2016.09( ISSN:2364-3722

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    DOI: 10.1055/s-0042-111906

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  • A Case of Non-Swelling Autoimmune Pancreatitis with Multiple Pancreatic Pseudocysts Reviewed

    Maruyama Hirotsugu, Tominaga Kazunari, Kato Kunihiro, Nagami Yasuaki, Sugimori Satoshi, Shiba Masatsugu, Watanabe Toshio, Fujiwara Yasuhiro, Kubo Yuki, Ohsawa Masahiko

    JOURNAL OF THE PANCREAS   17 ( 5 )   543 - 548   2016.09( ISSN:1590-8577

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  • NOD-Like Receptor Protein 3 Inflammasome Priming and Activation in Barrett's Epithelial Cells. Reviewed

    Nadatani Y, Huo X, Zhang X, Yu C, Cheng E, Zhang Q, Dunbar KB, Theiss A, Pham TH, Wang DH, Watanabe T, Fujiwara Y, Arakawa T, Spechler SJ, Souza RF

    Cellular and molecular gastroenterology and hepatology   2 ( 4 )   439 - 453   2016.07

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    DOI: 10.1016/j.jcmgh.2016.03.006

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  • Effect of Preoperative Biopsy on Colorectal Endoscopic Submucosal Dissection for Laterally Spreading Tumors: Using Propensity Score Matching Reviewed

    Fukunaga Shusei, Nagami Yasuaki, Shiba Masatsugu, Tanoue Koujiro, Hayashi Kappei, Kinoshita Yosuke, Sakai Taishi, Maruyama Hirotsugu, Kato Kunihiro, Minamino Hiroaki, Ominami Masaki, Sugimori Satoshi, Tanaka Fumio, Kamata Noriko, Yamagami Hirokazu, Tanigawa Tetsuya, Watanabe Toshio, Tominaga Kazunari, Fujiwara Yasuhiro, Arakawa Tetsuo

    GASTROINTESTINAL ENDOSCOPY   83 ( 5 )   AB118 - AB118   2016.05( ISSN:0016-5107

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  • Lithotripsy Is the Risk Factor of Post-Endoscopic Retrograde Cholangiopancreatography (PEP) Using Propensity Score Matching Analysis Reviewed

    Sugimori Satoshi, Shiba Masatsugu, Tanoue Koujiro, Kinoshita Yosuke, Hayashi Kappei, Sakai Taishi, Maruyama Hirotsugu, Minamino Hiroaki, Kato Kunihiro, Ominami Masaki, Fukunaga Shusei, Nagami Yasuaki, Tanaka Fumio, Tanigawa Tetsuya, Watanabe Toshio, Tominaga Kazunari, Fujiwara Yasuhiro, Arakawa Tetsuo

    GASTROINTESTINAL ENDOSCOPY   83 ( 5 )   AB260 - AB260   2016.05( ISSN:0016-5107

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  • Randomized Controlled Trial of Sedation: Comparing Propofol With Midazolam in Endoscopic Submucosal Dissection for Esophageal Squamous Cell Carcinoma Reviewed

    Ominami Masaki, Nagami Yasuaki, Shiba Masatsugu, Sakai Taishi, Maruyama Hirotsugu, Kato Kunihiro, Minamino Hiroaki, Fukunaga Shusei, Tanaka Fumio, Sugimori Satoshi, Kamata Noriko, Machida Hirohisa, Yamagami Hirokazu, Tanigawa Tetsuya, Watanabe Toshio, Tominaga Kazunari, Fujiwara Yasuhiro, Arakawa Tetsuo

    GASTROINTESTINAL ENDOSCOPY   83 ( 5 )   AB571 - AB572   2016.05( ISSN:0016-5107

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  • Predictive Endoscopic Findings of Positive Vertical Margin in Endoscopic Submucosal Dissection for Submucosal Invasive Colorectal Carcinoma: Towards Expanded Indications for Endoscopic Resection Reviewed

    Kinoshita Yosuke, Fukunaga Shusei, Nagami Yasuaki, Shiba Masatsugu, Tanoue Koujiro, Hayashi Kappei, Sakai Taishi, Maruyama Hirotsugu, Kato Kunihiro, Minamino Hiroaki, Ominami Masaki, Sugimori Satoshi, Tanaka Fumio, Kamata Noriko, Yamagami Hirokazu, Tanigawa Tetsuya, Watanabe Toshio, Tominaga Kazunari, Fujiwara Yasuhiro, Arakawa Tetsuo

    GASTROINTESTINAL ENDOSCOPY   83 ( 5 )   AB364 - AB365   2016.05( ISSN:0016-5107

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  • Mechanisms of NLRP3 inflammasome activation and its role in NSAID-induced enteropathy Reviewed

    Higashimori A., Watanabe T., Nadatani Y., Takeda S., Otani K., Tanigawa T., Yamagami H., Shiba M., Tominaga K., Fujiwara Y., Arakawa T.

    MUCOSAL IMMUNOLOGY   9 ( 3 )   659 - 668   2016.05( ISSN:1933-0219

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    DOI: 10.1038/mi.2015.89

  • Randomized Controlled Trial of Sedation: Comparing Propofol With Midazolam in Endoscopic Submucosal Dissection for Esophageal Squamous Cell Carcinoma Reviewed

    Ominami Masaki, Nagami Yasuaki, Shiba Masatsugu, Sakai Taishi, Maruyama Hirotsugu, Kato Kunihiro, Minamino Hiroaki, Fukunaga Shusei, Tanaka Fumio, Sugimori Satoshi, Kamata Noriko, Machida Hirohisa, Yamagami Hirokazu, Tanigawa Tetsuya, Watanabe Toshio, Tominaga Kazunari, Fujiwara Yasuhiro, Arakawa Tetsuo

    GASTROINTESTINAL ENDOSCOPY   83 ( 5 )   AB571 - AB572   2016.05( ISSN:0016-5107

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  • Single Locoregional Triamcinolone Injection Immediately After ESD for Superficial Esophageal Cancer Prevents Stricture Formation: A Propensity Score Matching Analysis Reviewed

    Nagami Yasuaki, Ominami Masaki, Shiba Masatsugu, Sakai Taishi, Minamino Hiroaki, Fukunaga Shusei, Sugimori Satoshi, Tanaka Fumio, Kamata Noriko, Yamagami Hirokazu, Tanigawa Tetsuya, Watanabe Toshio, Tominaga Kazunari, Fujiwara Yasuhiro, Arakawa Tetsuo

    GASTROINTESTINAL ENDOSCOPY   83 ( 5 )   AB583 - AB583   2016.05( ISSN:0016-5107

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  • Characteristics of nighttime reflux assessed using multichannel intraluminal impedance pH monitoring and a portable electroencephalograph Reviewed

    Fujiwara Y., Kohata Y., Nakahara K., Tanigawa T., Yamagami H., Shiba M., Watanabe K., Tominaga K., Watanabe T., Arakawa T.

    DISEASES OF THE ESOPHAGUS   29 ( 3 )   278 - 284   2016.04( ISSN:1120-8694

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    DOI: 10.1111/dote.12324

  • Locoregional steroid injection prevents stricture formation after endoscopic submucosal dissection for esophageal cancer: a propensity score matching analysis Reviewed

    Nagami Yasuaki, Shiba Masatsugu, Tominaga Kazunari, Minamino Hiroaki, Ominami Masaki, Fukunaga Shusei, Sugimori Satoshi, Tanigawa Tetsuya, Yamagami Hirokazu, Watanabe Kenji, Watanabe Toshio, Fujiwara Yasuhiro, Arakawa Tetsuo

    SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES   30 ( 4 )   1441 - 1449   2016.04( ISSN:0930-2794

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    DOI: 10.1007/s00464-015-4348-x

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  • Disorder of autonomic nervous system and its vulnerability to external stimulation in functional dyspepsia Reviewed

    Tominaga Kazunari, Fujikawa Yoshiko, Tsumoto Chikako, Kadouchi Kaori, Tanaka Fumio, Kamata Noriko, Yamagami Hirokazu, Tanigawa Tetsuya, Watanabe Toshio, Fujiwara Yasuhiro, Arakawa Tetsuo

    日本酸化ストレス学会 JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION   58 ( 2 )   161 - 165   2016.03( ISSN:0912-0009

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    To elucidate the role of autonomic nervous system in functional dyspepsia patients, we examined 24-h heart rate variability: the basal levels, responses after lunch, cold pressor and mental arithmetic tests, and the efficacy of an autonomic drug (tofisopam). The high-frequency component (HF: 0.15–0.40 Hz) and the ratio of HF to the low-frequency component (LF: 0.04–0.15 Hz; LF/HF ratio) were used as indicators of parasympathetic and sympathetic autonomic nervous system function. The HF component in the 24-h, daytime, and nighttime was low in 86.7%, 97.8%, and 66.7% of patients (<i>n</i> = 45) and the LF/HF ratio was high in 51.1%, 73.3%, and 26.6% of patients. Gastrointestinal symptom tended to be severe in patients with autonomic nervous system disorder (<i>p</i> = 0.085). The abnormal response in HF component after lunch occurred in 38.2% (13/34) of patients who revealed a greater tendency towards in indigestion score (<i>p</i> = 0.061). Delays in recovery to the basal autonomic nervous system level after stimulus of the cold pressor and the mental arithmetic tests occurred in parts of patients. Tofisopam partially improved autonomic nervous system dysfunction and abdominal pain/indigestion. Imbalanced autonomic nervous system function and vulnerability for recovery from external stimuli were observed in functional dyspepsia patients, which was associated with dyspeptic symptoms.

    DOI: 10.3164/jcbn.15-140

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  • Structural changes in gastric glial cells and delayed gastric emptying as responses to early life stress and acute adulthood stress in rats Reviewed

    Tominaga Kazunari, Fujikawa Yoshiko, Tanaka Fumio, Kamata Noriko, Yamagami Hirokazu, Tanigawa Tetsuya, Watanabe Toshio, Fujiwara Yasuhiro, Arakawa Tetsuo

    LIFE SCIENCES   148   254 - 259   2016.03( ISSN:0024-3205

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    DOI: 10.1016/j.lfs.2016.02.025

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  • Long-Term Benefits of Smoking Cessation on Gastroesophageal Reflux Disease and Health-Related Quality of Life Reviewed

    Kohata Yukie, Fujiwara Yasuhiro, Watanabe Takanori, Kobayashi Masanori, Takemoto Yasuhiko, Kamata Noriko, Yamagami Hirokazu, Tanigawa Tetsuya, Shiba Masatsugu, Watanabe Toshio, Tominaga Kazunari, Shuto Taichi, Arakawa Tetsuo

    PLOS ONE   11 ( 2 )   e0147860   2016.02( ISSN:1932-6203

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    DOI: 10.1371/journal.pone.0147860

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  • Comparison of Risk Factors Between Small Intestinal Ulcerative and Vascular Lesions in Occult Versus Overt Obscure Gastrointestinal Bleeding Reviewed

    Okamoto Junichi, Tominaga Kazunari, Sugimori Satoshi, Kato Kunihiro, Minamino Hiroaki, Ominami Masaki, Fukunaga Shusei, Nagami Yasuaki, Kamata Noriko, Yamagami Hirokazu, Tanigawa Tetsuya, Shiba Masatsugu, Watanabe Toshio, Fujiwara Yasuhiro, Arakawa Tetsuo

    DIGESTIVE DISEASES AND SCIENCES   61 ( 2 )   533 - 541   2016.02( ISSN:0163-2116

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    DOI: 10.1007/s10620-015-3904-5

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  • Reduction of prostaglandin transporter predicts poor prognosis associated with angiogenesis in gastric adenocarcinoma Reviewed

    Takeda Shogo, Tanigawa Tetsuya, Watanabe Toshio, Tatsuwaki Hiroshi, Nadatani Yuji, Otani Koji, Nagami Yasuaki, Tanaka Fumio, Kamata Noriko, Yamagami Hirokazu, Shiba Masatsugu, Tominaga Kazunari, Fujiwara Yasuhiro, Muguruma Kazuya, Ohira Masaichi, Hirakawa Kosei, Arakawa Tetsuo

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   31 ( 2 )   376 - 383   2016.02( ISSN:0815-9319

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    DOI: 10.1111/jgh.13079

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  • A novel endoscopic technique for closure of a large esophageal perforation using the clip-and-snare method with the prelooping technique Reviewed

    Nagami Yasuaki, Shiba Masatsugu, Ominami Masaki, Tominaga Kazunari, Watanabe Toshio, Fujiwara Yasuhiro, Arakawa Tetsuo

    ENDOSCOPY   48   E250 - E251   2016( ISSN:0013-726X

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    DOI: 10.1055/s-0042-110488

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  • Prediction of Poor Response to Modified Neuroleptanalgesia with Midazolam for Endoscopic Submucosal Dissection for Esophageal Squamous Cell Carcinoma Reviewed

    Ominami Masaki, Nagami Yasuaki, Shiba Masatsugu, Tominaga Kazunari, Maruyama Hirotsugu, Okamoto Junichi, Kato Kunihiro, Minamino Hiroaki, Fukunaga Shusei, Sugimori Satoshi, Yamagami Hirokazu, Tanigawa Tetsuya, Watanabe Toshio, Fujiwara Yasuhiro, Arakawa Tetsuo

    DIGESTION   94 ( 2 )   73 - 81   2016( ISSN:0012-2823

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    DOI: 10.1159/000447666

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  • The Japanese Guideline for Functional Dyspepsia in 2014 Reviewed

    Tominaga Kazunari, Fujikawa Yoshiko, Tanaka Fumio, Tanigawa Tetsuya, Watanabe Toshio, Fujiwara Yasuhiro, Arakawa Tetsuo

    Japanese Society of Psychosomatic Medicine, Japanese Journal of Psychosomatic Medicine   56 ( 10 )   977 - 985   2016( ISSN:0385-0307

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    <p>Recently, the Japanese guideline for functional dyspepsia (FD) has been published in 2014, which introduces many papers including randomized placebo controlled studies showing accumulating evidences about the pathogenesis of FD in Japan. However, the pathogenesis of FD still remains unknown. Physiological dysfunctions of gastric acid secretion and gastrointestinal motility may cause dyspeptic symptoms. Therefore, it is focused on the efficacy of acid suppressant and prokinetic agents for the treatment of FD. In addition, it proposes the diagnostic and therapeutic flow for management of patients with dyspepsia. Although this is based on the useful data derived from multiple clinical trials, this flow alone cannot be always effective for all patients with FD. If poor outcomes occur after the recommended treatment using such standard drugs, alternative therapy is required. As a next step after the gastroenterological treatment, psychosomatic treatment is often selected. However, gastroenterologists are generally unfamiliar with psychosomatic treatment. This review summarizes the Japanese guideline for FD and proposes present clinical problems including visceral hypersensitivity in relation to the role of psychology.</p>

    DOI: 10.15064/jjpm.56.10_977

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  • Correction: Long-Term Benefits of Smoking Cessation on Gastroesophageal Reflux Disease and Health-Related Quality of Life. Reviewed

    Kohata Y, Fujiwara Y, Watanabe T, Kobayashi M, Takemoto Y, Kamata N, Yamagami H, Tanigawa T, Shiba M, Watanabe T, Tominaga K, Shuto T, Arakawa T

    PloS one   11 ( 3 )   e0150554   2016

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    DOI: 10.1371/journal.pone.0150554

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  • Characteristics of Sleep Disturbances in Patients with Gastroesophageal Reflux Disease Reviewed

    Iwakura Narika, Fujiwara Yasuhiro, Shiba Masatsugu, Ochi Masahiro, Fukuda Takashi, Tanigawa Tetsuya, Yamagami Hirokazu, Tominaga Kazunari, Watanabe Toshio, Arakawa Tetsuo

    一般社団法人 日本内科学会 INTERNAL MEDICINE   55 ( 12 )   1511 - 1517   2016( ISSN:0918-2918

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    <b>Objective </b>Gastroesophageal reflux disease (GERD) is strongly associated with sleep disturbances; however, the detailed differences in the characteristics of sleep disturbances between GERD and non-GERD patients are unknown. The aim of the present study was to analyze the clinical characteristics as well as health-related quality of life in GERD and non-GERD patients with sleep disturbances. <b>Methods </b>Three hundred and fifty patients, including 124 patients with GERD and 226 patients without GERD, completed a self-administered questionnaire that evaluated clinical information. The Pittsburg Sleep Quality Index (PSQI), Hospital Anxiety and Depression Scale (HADS), Insomnia Severity Index (ISI), Epworth Sleepiness Scale (ESS) and 8-item Short-Form Health Survey (SF-8) were also used. Sleep disturbance was considered to be present if the PSQI was >5.5. <b>Results </b>The prevalence of sleep disturbances was significantly higher in the GERD patients (66/124, 53.9%) than in the non-GERD patients (89/226, 39.3%). Depression and anxiety were significantly more common in the subjects with sleep disturbances than in those without sleep disturbances, although there were no differences between the GERD and non-GERD patients. Among the subjects with sleep disturbances, daytime sleepiness was more common in the GERD patients than in the non-GERD patients. The subjects with sleep disturbances had a poorer health-related quality of life. The physical components of quality of life were impaired, particularly in the GERD patients with sleep disturbances. <b>Conclusion </b>GERD patients with sleep disturbances commonly experience daytime sleepiness and an impaired health-related quality of life, especially in terms of physical components.

    DOI: 10.2169/internalmedicine.55.5454

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  • A Case of Rapidly Progressed Primary Pleural Synovial Sarcoma Reviewed

    Asai Kazuhisa, Sato Kanako, Kubo Yuko, Okamoto Atsuko, Yamada Kazuhiro, Yoshii Naoko, Watanabe Tetsuya, Konishi Kazuhisa, Uji Masato, Hirata Kazuto

    CHEST   148 ( 4 )   2015.10( ISSN:0012-3692

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    DOI: 10.1378/chest.2233073

  • Regional brain disorders of serotonin neurotransmission are associated with functional dyspepsia Reviewed

    Tominaga Kazunari, Tsumoto Chikako, Ataka Suzuka, Mizuno Kei, Takahashi Kayo, Yamagami Hirokazu, Tanigawa Tetsuya, Kawabe Joji, Watanabe Toshio, Fujiwara Yasuhiro, Shiomi Susumu, Watanabe Yasuyoshi, Arakawa Tetsuo

    LIFE SCIENCES   137   150 - 157   2015.09( ISSN:0024-3205

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    DOI: 10.1016/j.lfs.2015.07.023

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  • Mechanisms of Activation of the NLRP3 Inflammasome and Its Role in NSAID-Induced Small Intestinal Damage Reviewed

    Watanabe Toshio, Higashimori Akira, Nadatani Yuji, Tanigawa Tetsuya, Tominaga Kazunari, Fujiwara Yasuhiro, Arakawa Tetsuo

    DIGESTIVE DISEASES AND SCIENCES   60 ( 9 )   2563 - 2563   2015.09( ISSN:0163-2116

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  • Small Bowel Injury Caused by NSAIDs/Aspirin: From Bases to Clinical Site Reviewed

    Arakawa Tetsuo, Watanabe Toshio, Tanigawa Tetsuya

    DIGESTIVE DISEASES AND SCIENCES   60 ( 9 )   2562 - 2562   2015.09( ISSN:0163-2116

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  • Inhibitory Effect of Rebamipide on Indomethacin-Induced Experimental Small Intestinal Injury and Exacerbation of the Injury Induced by Proton Pump Inhibitor: Possible Involvement of Modulation of Intestinal Microbiota by Rebamipide Reviewed

    Tanigawa Tetsuya, Watanabe Toshio, Takeda Shogo, Higashimori Akira, Shimada Sunao, Nadatani Yuji, Otani Koji, Tanaka Fumio, Kamata Noriko, Nagami Yasuaki, Yamagami Hirokazu, Shiba Masatsugu, Tominaga Kazunari, Fujiwara Yasuhiro, Arakawa Tetsuo

    DIGESTIVE DISEASES AND SCIENCES   60 ( 9 )   2562 - 2562   2015.09( ISSN:0163-2116

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  • Rebamipide Alters the Esophageal Microbiome and Reduces the Incidence of Barrett's Esophagus in a Rat Model Reviewed

    Kohata Yukie, Nakahara Kenichi, Tanigawa Tetsuya, Yamagami Hirokazu, Shiba Masatsugu, Watanabe Toshio, Tominaga Kazunari, Fujiwara Yasuhiro, Arakawa Tetsuo

    DIGESTIVE DISEASES AND SCIENCES   60 ( 9 )   2654 - 2661   2015.09( ISSN:0163-2116

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    DOI: 10.1007/s10620-015-3662-4

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  • Booster influenza vaccination does not improve immune response in adult inflammatory bowel disease patients treated with immunosuppressives: a randomized controlled trial Reviewed

    Matsumoto Hiroko, Ohfuji Satoko, Watanabe Kenji, Yamagami Hirokazu, Fukushima Wakaba, Maeda Kazuhiro, Kamata Noriko, Sogawa Mitsue, Shiba Masatsugu, Tanigawa Tetsuya, Tominaga Kazunari, Watanabe Toshio, Fujiwara Yasuhiro, Hirota Yoshio, Arakawa Tetsuo

    JOURNAL OF GASTROENTEROLOGY   50 ( 8 )   876 - 886   2015.08( ISSN:0944-1174

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    DOI: 10.1007/s00535-015-1042-7

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  • NERVE GROWTH FACTOR INJECTED INTO THE GASTRIC ULCER BASE INCORPORATES INTO ENDOTHELIAL, NEURONAL, GLIAL AND EPITHELIAL CELLS: IMPLICATIONS FOR ANGIOGENESIS, MUCOSAL REGENERATION AND ULCER HEALING Reviewed

    Tanigawa T., Ahluwalia A., Watanabe T., Arakawa T., Tarnawski A. S.

    JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY   66 ( 4 )   617 - 621   2015.08( ISSN:0867-5910

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  • [Kampo medicine (rikkunshito)]. Reviewed

    Tominaga K, Tanigawa T, Watanabe T, Fujiwara Y, Arakawa T

    Nihon rinsho. Japanese journal of clinical medicine   73 ( 7 )   1179 - 84   2015.07( ISSN:0047-1852

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  • Enteric glial cells are associated with stress-induced colonic hyper-contraction in maternally separated rats Reviewed

    Fujikawa Y., Tominaga K., Tanaka F., Tanigawa T., Watanabe T., Fujiwara Y., Arakawa T.

    NEUROGASTROENTEROLOGY AND MOTILITY   27 ( 7 )   1010 - 1023   2015.07( ISSN:1350-1925

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    DOI: 10.1111/nmo.12577

  • Associations between endoscopic findings and functional assessment via multichannel intraluminal impedance-pH monitoring in patients with non-erosive reflux disease refractory to proton-pump inhibitors Reviewed

    Fujiwara Yasuhiro, Kohata Yukie, Tanigawa Tetsuya, Yamagami Hirokazu, Shiba Masatsugu, Tominaga Kazunari, Watanabe Toshio, Arakawa Tetsuo

    ESOPHAGUS   12 ( 3 )   244 - 250   2015.07( ISSN:1612-9059

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    DOI: 10.1007/s10388-014-0480-2

  • [Significances and issues for capsule endoscopy in patients with Crohn's disease -toward the appropriate use]. Reviewed

    Watanabe K, Hosomi S, Noguchi A, Yukawa T, Kamata N, Yamagami H, Tominaga K, Watanabe T, Fujiwara Y, Nebiki H, Arakawa T

    Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology   112 ( 7 )   1259 - 69   2015.07( ISSN:0446-6586

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    DOI: 10.11405/nisshoshi.112.1259

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  • Long-term efficacy and safety of rabeprazole in patients taking low-dose aspirin with a history of peptic ulcers: a phase 2/3, randomized, parallel group, multicenter, extension clinical trial Reviewed

    Fujishiro Mitsuhiro, Higuchi Kazuhide, Kato Mototsugu, Kinoshita Yoshikazu, Iwakiri Ryuichi, Watanabe Toshio, Takeuchi Toshihisa, Sugisaki Nobuyuki, Okada Yasushi, Ogawa Hisao, Arakawa Tetsuo, Fujimoto Kazuma

    日本酸化ストレス学会 JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION   56 ( 3 )   228 - 239   2015.05( ISSN:0912-0009

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    A 24-week, double-blind, clinical trial of rabeprazole for the prevention of recurrent peptic ulcers caused by low-dose aspirin (LDA) has been reported, but trials for longer than 24 weeks have not been reported. The aim of this study is to assess the long-term efficacy and safety of rabeprazole for preventing peptic ulcer recurrence on LDA therapy. Eligible patients had a history of peptic ulcers on long-term LDA (81 or 100 mg/day) therapy. Patients with no recurrence of peptic ulcers at the end of the 24-week double-blind phase with rabeprazole (10- or 5-mg once daily) or teprenone (50 mg three times daily) entered the extension phase. Rabeprazole doses were maintained for a maximum of 76 weeks, including the double-blind 24-week period and the extension phase period (long-term rabeprazole 10- and 5-mg groups). Teprenone was randomly switched to rabeprazole 10 or 5 mg for a maximum of 52 weeks in the extension phase (newly-initiated rabeprazole 10- and 5-mg groups). The full analysis set consisted of 151 and 150 subjects in the long-term rabeprazole 10- and 5-mg groups, respectively, and the cumulative recurrence rates of peptic ulcers were 2.2 and 3.7%, respectively. Recurrent peptic ulcers were not observed in the newly-initiated rabeprazole 10- and 5-mg groups. No bleeding ulcers were reported. No clinically significant safety findings, including cardiovascular events, emerged. The use of long-term rabeprazole 10- and 5-mg once daily prevents the recurrence of peptic ulcers in subjects on low-dose aspirin therapy, and both were well-tolerated.

    DOI: 10.3164/jcbn.15-1

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  • The Five-Year Survival Rate After Endoscopic Submucosal Dissection for Superficial Esophageal Squamous Cell Carcinoma Reviewed

    Ominami Masaki, Nagami Yasuaki, Shiba Masatsugu, Sakai Taishi, Maruyama Hirotsugu, Okamoto Junichi, Kato Kunihiro, Minamino Hiroaki, Fukunaga Shusei, Tanaka Fumio, Sugimori Satoshi, Kamata Noriko, Yamagami Hirokazu, Tanigawa Tetsuya, Watanabe Toshio, Tominaga Kazunari, Fujiwara Yasuhiro, Arakawa Tetsuo

    GASTROINTESTINAL ENDOSCOPY   81 ( 5 )   AB516 - AB517   2015.05( ISSN:0016-5107

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  • Efficacy of Concomitant Elemental Diet Therapy in Scheduled Infliximab Therapy in Patients with Crohn's Disease to Prevent Loss of Response Reviewed

    Kamata Noriko, Oshitani Nobuhide, Watanabe Kenji, Watanabe Kimihiko, Hosomi Shuhei, Noguchi Atsushi, Yukawa Tomomi, Yamagami Hirokazu, Shiba Matsatsugu, Tanigawa Tetsuya, Watanabe Toshio, Tominaga Kazunari, Fujiwara Yasuhiro, Arakawa Tetsuo

    DIGESTIVE DISEASES AND SCIENCES   60 ( 5 )   1382 - 1388   2015.05( ISSN:0163-2116

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    DOI: 10.1007/s10620-014-3493-8

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  • Long-Term Prognosis of Expanded-Indication Lesions of Differentiated-Type Early Gastric Cancer: a Comparative Analysis Using Propensity Score Matching Between Endoscopic Submucosal Dissection and Surgery Reviewed

    Fukunaga Shusei, Nagami Yasuaki, Shiba Masatsugu, Tanaka Hiroaki, Muguruma Kazuya, Minamino Hiroaki, Ominami Masaki, Sugimori Satoshi, Tanigawa Tetsuya, Yamagami Hirokazu, Watanabe Toshio, Tominaga Kazunari, Fujiwara Yasuhiro, Ohira Masaichi, Hirakawa Kosei, Arakawa Tetsuo

    GASTROINTESTINAL ENDOSCOPY   81 ( 5 )   AB197 - AB197   2015.05( ISSN:0016-5107

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  • Novel Diagnostic Findings on Capsule Endoscopy in the Small Bowel of Patients With Crohn's Disease Reviewed

    Watanabe Kenji, Noguchi Atsushi, Miyazaki Takako, Morimoto Kenichi, Hosomi Shuhei, Yukawa Tomomi, Kamata Noriko, Yamagami Hirokazu, Tominaga Kazunari, Watanabe Toshio, Fujiwara Yasuhiro, Nakamura Shiro, Nebiki Hiroko, Arakawa Tetsuo

    GASTROINTESTINAL ENDOSCOPY   81 ( 5 )   AB473 - AB473   2015.05( ISSN:0016-5107

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  • Safety and Long-Term Survival of Endoscopic Submucosal Dissection for Superficial Esophageal Squamous Cell Carcinoma in Elderly Patients Reviewed

    Nagami Yasuaki, Ominami Masaki, Shiba Masatsugu, Sakai Taishi, Maruyama Hirotsugu, Okamoto Junichi, Kato Kunihiro, Minamino Hiroaki, Fukunaga Shusei, Tanaka Fumio, Sugimori Satoshi, Kamata Noriko, Yamagami Hirokazu, Tanigawa Tetsuya, Watanabe Toshio, Tominaga Kazunari, Fujiwara Yasuhiro, Arakawa Tetsuo

    GASTROINTESTINAL ENDOSCOPY   81 ( 5 )   AB516 - AB516   2015.05( ISSN:0016-5107

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  • Evaluation of Clinical Factors Associated With Positive Capsule Endoscopy Findings in Patients With Obscure Gastrointestinal Bleeding: a Single-Center Analysis Reviewed

    Shimada Sunao, Watanabe Toshio, Nadatani Yuji, Takeda Shogo, Otani Koji, Tanaka Fumio, Kamata Noriko, Yamagami Hirokazu, Tanigawa Tetsuya, Shiba Masatsugu, Tominaga Kazunari, Fujiwara Yasuhiro, Arakawa Tetsuo

    GASTROINTESTINAL ENDOSCOPY   81 ( 5 )   AB478 - AB479   2015.05( ISSN:0016-5107

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  • A Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial of High-Dose Rebamipide Treatment for Low-Dose Aspirin-Induced Moderate-to-Severe Small Intestinal Damage Reviewed

    Watanabe Toshio, Takeuchi Toshihisa, Handa Osamu, Sakata Yasuhisa, Tanigawa Tetsuya, Shiba Masatsugu, Naito Yuji, Higuchi Kazuhide, Fujimoto Kazuma, Yoshikawa Toshikazu, Arakawa Tetsuo

    PLOS ONE   10 ( 4 )   e0122330   2015.04( ISSN:1932-6203

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    DOI: 10.1371/journal.pone.0122330

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  • Basophil infiltration in eosinophilic oesophagitis and proton pump inhibitor-responsive oesophageal eosinophilia Reviewed

    Iwakura N., Fujiwara Y., Tanaka F., Tanigawa T., Yamagami H., Shiba M., Tominaga K., Watanabe T., Iijima K., Koike T., Walls A. F., Arakawa T.

    ALIMENTARY PHARMACOLOGY & THERAPEUTICS   41 ( 8 )   776 - 784   2015.04( ISSN:0269-2813

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    DOI: 10.1111/apt.13141

  • Association between chronic use of proton pump inhibitors and small- intestinal bacterial overgrowth assessed using lactulose hydrogen breath tests. Reviewed

    Fujiwara Y, Watanabe T, Muraki M, Yamagami H, Tanigawa T, Shiba M, Tominaga K, Arakawa T

    Hepato-gastroenterology   62 ( 138 )   268 - 72   2015.03( ISSN:0172-6390

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  • Usefulness of baseline impedance in patients with proton pump inhibitor-refractory nonerosive reflux disease Reviewed

    Kohata Yukie, Fujiwara Yasuhiro, Yamagami Hirokazu, Tanigawa Tetsuya, Shiba Masatsugu, Watanabe Kenji, Watanabe Toshio, Tominaga Kazunari, Arakawa Tetsuo

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   30   36 - 40   2015.03( ISSN:0815-9319

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    DOI: 10.1111/jgh.12743

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  • Clinical impact of ultrathin colonoscopy for Crohn's disease patients with strictures Reviewed

    Morimoto Kenichi, Watanabe Kenji, Noguchi Atsushi, Miyazaki Takako, Nagami Yasuaki, Sugimori Satoshi, Kamata Noriko, Sogawa Mitsue, Tanigawa Tetsuya, Yamagami Hirokazu, Shiba Masatsugu, Tominaga Kazunari, Watanabe Toshio, Fujiwara Yasuhiro, Arakawa Tetsuo

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   30   66 - 70   2015.03( ISSN:0815-9319

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    DOI: 10.1111/jgh.12739

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  • Tumor Necrosis Factor alpha Decreases Glucagon-Like Peptide-2 Expression by Up-Regulating G-Protein-Coupled Receptor 120 in Crohn Disease Reviewed

    Tsukahara Takuya, Watanabe Kenji, Watanabe Toshio, Yamagami Hirokazu, Sogawa Mitsue, Tanigawa Tetsuya, Shiba Masatsugu, Tominaga Kazunari, Fujiwara Yasuhiro, Maeda Kiyoshi, Hirakawa Kosei, Arakawa Tetsuo

    AMERICAN JOURNAL OF PATHOLOGY   185 ( 1 )   185 - 196   2015.01( ISSN:0002-9440

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    DOI: 10.1016/j.ajpath.2014.09.010

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  • Association between Chronic Use of Proton Pump Inhibitors and Small-Intestinal Bacterial Overgrowth Assessed using Lactulose Hydrogen Breath Tests Reviewed

    Fujiwara Yasuhiro, Watanabe Toshio, Muraki Motoko, Yamagami Hirokazu, Tanigawa Tetsuya, Shiba Masatsugu, Tominaga Kazunari, Arakawa Tetsuo

    HEPATO-GASTROENTEROLOGY   62 ( 138 )   268 - 272   2015( ISSN:0172-6390

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    DOI: 10.5754/hge14878

  • Gastric Glial Cells as Responses to Early Life Stress (Maternal Separation) and Acute Stress in Adulthood in Rats Reviewed

    Tominaga Kazunari, Fujikawa Yoshiko, Tanaka Fumio, Sogawa Mitsue, Yamagami Hirokazu, Tanigawa Tetsuya, Shiba Masatsugu, Watanabe Kenji, Watanabe Toshio, Fujiwara Yasuhiro, Arakawa Tetsuo

    DIGESTION   91 ( 1 )   87 - 87   2015( ISSN:0012-2823

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  • Treatment for Functional Dyspepsia with Various Kinds of Drug of the Gastroenterological Field(Searching Optimal Treatment for Functional Gastrointestinal Disorders) Reviewed

    Tominaga Kazunari, Fujikawa Yoshiko, Tanaka Fumio, Tanigawa Tetsuya, Watanabe Toshio, Fujiwara Yasuhiro, Arakawa Tetsuo

    Japanese Society of Psychosomatic Medicine, Japanese Journal of Psychosomatic Medicine   55 ( 3 )   224 - 232   2015( ISSN:0385-0307

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    Pathogenesis of functional dyspepsia (FD) is not far from the aspect of psychosomatic medicine. Various disorders of physiological function of the gastrointestinal tract such as gastric acid secretion and motility are associated with pathogenesis of FD. Hence, on the basis of brain-gut-interaction, gastrointestinal physiological functions are also regulated by psychosomatic effects. Clinical guideline of FD was published in 2014 in Japan. It comprehensively reveals the concept, etiology, pathogenesis, and treatment of FD. However, it has not been a complete one, particularly because, the treatment flow chart is not always adapted to every patient with FD. In general, placebo effect is often high in clinical trials of FD treatment. Therefore, efficacy of specific type of drugs or individual drug has not been completely proven by randomized placebo-control studies. Thus, further clinical evidences will be needed for seeking definite therapeutic strategy for FD management.

    DOI: 10.15064/jjpm.55.3_224

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  • SUCCESSFUL TREATMENT OF LOCALIZED EOSINOPHILIC ESOPHAGITIS WITH A PROTON PUMP INHIBITOR Reviewed

    FUJIWARA Yasuhiro, IWAKURA Narika, HASHIMOTO Atsushi, UEMURA Risa, SAWADA Akinari, HIRAMOTO Keiko, SUGAWA Takashi, TOMINAGA Kazunari, WATANABE Toshio, ARAKAWA Tetsuo

    Japan Gastroenterological Endoscopy Society, GASTROENTEROLOGICAL ENDOSCOPY   57 ( 10 )   2436 - 2440   2015

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    A 44-year-old woman had a two-year history of food impaction. Esophago-gastro-duodenoscopy showed white exudates with fine furrows localized at the esophago-gastric junction. Examination of biopsy specimens showed marked intraepithelial infiltration of eosinophils (50 per high power field) in the esophageal mucosa. She was diagnosed as having localized eosinophilic esophagitis and received rabeprazole for 8 weeks. After treatment, her symptoms as well as endoscopic images and esophageal eosinophil infiltration improved. Here, we presented a patient with localized eosinophilic esophagitis that was successfully treated with a proton pump inhibitor.

    DOI: 10.11280/gee.57.2436

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  • Successful Treatment of Early-Diagnosed Primary Phlegmonous Gastritis Reviewed

    Kato Kunihiro, Tominaga Kazunari, Sugimori Satoshi, Nagami Yasuaki, Kamata Noriko, Yamagami Hirokazu, Tanigawa Tetsuya, Shiba Masatsugu, Watanabe Toshio, Fujiwara Yasuhiro, Arakawa Tetsuo

    一般社団法人 日本内科学会 INTERNAL MEDICINE   54 ( 22 )   2863 - 2866   2015( ISSN:0918-2918

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    A 64-year-old man presented with epigastralgia and nausea after an acute exacerbation of chronic pancreatitis. Abdominal computed tomography revealed remarkable thickening of the gastric wall and intramural hypodense areas. Esophagogastroduodenoscopy showed a large gastric ulcer surrounded by an edematous mucosa and mucopus. The results of a culture from a biopsy of the lesion indicated phlegmonous gastritis. The patient was successfully treated with an antibiotic without gastrectomy.<br>

    DOI: 10.2169/internalmedicine.54.4257

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  • Rectal biopsy, rather than ileal, is appropriate to confirm the diagnosis of early gastrointestinal graft-versus-host disease Reviewed

    Minamino Hiroaki, Machida Hirohisa, Tominaga Kazunari, Morimoto Kenichi, Ominami Masaki, Fukunaga Shusei, Hosomi Shuhei, Hayashi Yoshiki, Nagami Yasuaki, Sugimori Satoshi, Kamata Noriko, Shiba Masatsugu, Nakamae Hirohisa, Yamagami Hirokazu, Tanigawa Tetsuya, Watanabe Toshio, Fujiwara Yasuhiro, Ohsawa Masahiko, Hino Masayuki, Arakawa Tetsuo

    SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY   50 ( 11 )   1428 - 1434   2015( ISSN:0036-5521

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    DOI: 10.3109/00365521.2015.1054421

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  • Pharmacological Treatment for Functional Dyspepsia and Irritable Bowel Syndrome : Current Standards and Promising Therapies Reviewed

    Tominaga Kazunari, Fujikawa Yoshiko, Tanaka Fumio, Tanigawa Tetsuya, Watanabe Toshio, Fujiwara Yasuhiro, Arakawa Tetsuo

    一般社団法人 日本プライマリ・ケア連合学会 Journal of General and Family Medicine   16 ( 4 )   242 - 251   2015

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    Functional dyspepsia (FD) and irritable bowel syndrome (IBS) are functional diseases without identified organic cause and intruduced as part of the Rome III criteria published in 2006. Because of non-organic diseases, pharmacological treatment (not invasive surgical treatment) is the preferred therapy for such diseases. Meanwhile, evidence-based clinical practice guidelines for FD and IBS have been published in Japan. However, no definite therapeutic strategy for FD and IBS has yet been established. To understand more appropriate treatments according to the respective pathophysiology, this review introduces the several pharmacological treatments including current standards and proposes future promising therapies based on these guidelines. First, this review covered clinical evidence for standard and recommended drugs such as acid suppressants, prokinetics, probiotics, and bulking polymers for the management of FD and IBS. Next, this review progressed to propose future promising treatments for their managements. A comprehensive understanding of relevant therapeutic regimens and pharmacological treatment using drug candidates including future promising drugs is required for the optimal and more effective treatment of FD and IBS.

    DOI: 10.14442/jgfm.16.4_242

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  • Effects of Esomeprazole on Sleep in Patients with Gastroesophageal Reflux Disease as Assessed on Actigraphy Reviewed

    Hiramoto Keiko, Fujiwara Yasuhiro, Ochi Masahiro, Okuyama Masatsugu, Tanigawa Tetsuya, Yamagami Hirokazu, Shiba Masatsugu, Watanabe Kenji, Watanabe Toshio, Tominaga Kazunari, Arakawa Tetsuo

    一般社団法人 日本内科学会 INTERNAL MEDICINE   54 ( 6 )   559 - 565   2015( ISSN:0918-2918

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    <b>Objective</b> Gastroesophageal reflux disease (GERD) is strongly associated with sleep disturbances. Although treatment with proton pump inhibitors (PPIs) helps to improve GERD symptoms and subjective sleep parameters, the effects of PPI therapy on objective sleep parameters are conflicting. The aim of this study was to examine the effects of esomeprazole treatment on GERD symptoms and sleep parameters assessed using actigraphs and questionnaires.<br> <b>Methods</b> Thirteen patients with GERD received 20 mg of esomeprazole once daily for two weeks. The patients wore actigraphs from three days before the initiation of PPI treatment to the end of therapy. They were also asked to answer the following self-reported questionnaires: Frequency Scale for the Symptoms of GERD (FSSG), Pittsburg Sleep Quality Index (PSQI) and Epworth Sleepiness Scale (ESS). Objective sleep parameters were evaluated using actigraphy.<br> <b>Results</b> Treatment with esomeprazole significantly decreased the total FSSG score, including the scores for reflux and dysmotility, as well as the ESS score, although it had no effect on the PSQI score. After the second week of treatment, esomeprazole significantly decreased the wake time (from 47.5&plusmn;39.6 min to 36.0&plusmn;27.1 min) and sleep latency period (from 19.5&plusmn;19.8 min to 9.9&plusmn;10.2 min) and increased the percentage of sleep time (from 89.1&plusmn;8.8% to 91.9&plusmn;6.3%); however, improvements were not noted in all objective parameters.<br> <b>Conclusion</b> Esomeprazole treatment significantly improves various objective sleep parameters in Japanese patients with GERD. Further placebo-controlled randomized trials are needed to obtain detailed results.<br>

    DOI: 10.2169/internalmedicine.54.3718

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  • Toll-Like Receptor 2 Mediates Ischemia-Reperfusion Injury of the Small Intestine in Adult Mice Reviewed

    Watanabe Toshio, Tanigawa Tetsuya, Kobata Atsushi, Takeda Shogo, Nadatani Yuji, Otani Koji, Yamagami Hirokazu, Shiba Masatsugu, Tominaga Kazunari, Fujiwara Yasuhiro, Arakawa Tetsuo

    PLOS ONE   9 ( 10 )   e110441   2014.10( ISSN:1932-6203

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    DOI: 10.1371/journal.pone.0110441

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  • Randomised clinical trial: prevention of recurrence of peptic ulcers by rabeprazole in patients taking low-dose aspirin Reviewed

    Iwakiri R., Higuchi K., Kato M., Fujishiro M., Kinoshita Y., Watanabe T., Takeuchi T., Yamauchi M., Sanomura M., Nakagawa H., Sugisaki N., Okada Y., Ogawa H., Arakawa T., Fujimoto K.

    ALIMENTARY PHARMACOLOGY & THERAPEUTICS   40 ( 7 )   780 - 795   2014.10( ISSN:0269-2813

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    DOI: 10.1111/apt.12907

  • Acid Reflux Directly Causes Sleep Disturbances in Rat with Chronic Esophagitis Reviewed

    Nakahara Kenichi, Fujiwara Yasuhiro, Tsukahara Takuya, Yamagami Hirokazu, Tanigawa Tetsuya, Shiba Masatsugu, Tominaga Kazunari, Watanabe Toshio, Urade Yoshihiro, Arakawa Tetsuo

    PLOS ONE   9 ( 9 )   e106969   2014.09( ISSN:1932-6203

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    DOI: 10.1371/journal.pone.0106969

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  • The prevalence of adverse events associated with double-balloon enteroscopy from a single-centre dataset in Japan Reviewed

    Nakayama Sayoko, Tominaga Kazunari, Obayashi Tomoko, Okamoto Junichi, Minamino Hiroaki, Ominami Masaki, Fukunaga Shusei, Nagami Yasuaki, Sugimori Satoshi, Machida Hirohisa, Okazaki Hirotoshi, Sogawa Mitsue, Yamagami Hirokazu, Tanigawa Tetsuya, Watanabe Kenji, Watanabe Toshio, Fujiwara Yasuhiro, Arakawa Tetsuo

    DIGESTIVE AND LIVER DISEASE   46 ( 8 )   706 - 709   2014.08( ISSN:1590-8658

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    DOI: 10.1016/j.dld.2014.03.016

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  • [Rome III classification and characteristics of Japanese patients with functional dyspepsia]. Reviewed

    Tominaga K, Fujikawa Y, Tanaka F, Tanigawa T, Shiba M, Watanabe T, Fujiwara Y, Arakawa T

    Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology   111 ( 6 )   1079 - 87   2014.06( ISSN:0446-6586

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  • Usefulness of Non-Magnifying Narrow-Band Imaging in Screening of Early Esophageal Squamous Cell Carcinoma: A Prospective Comparative Study Using Propensity Score Matching Reviewed

    Nagami Yasuaki, Tominaga Kazunari, Machida Hirohisa, Nakatani Masami, Kameda Natsuhiko, Sugimori Satoshi, Okazaki Hirotoshi, Tanigawa Tetsuya, Yamagami Hirokazu, Kubo Naoshi, Shiba Masatsugu, Watanabe Kenji, Watanabe Toshio, Iguchi Hiroyoshi, Fujiwara Yasuhiro, Ohira Masaichi, Hirakawa Kosei, Arakawa Tetsuo

    AMERICAN JOURNAL OF GASTROENTEROLOGY   109 ( 6 )   845 - 854   2014.06( ISSN:0002-9270

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    DOI: 10.1038/ajg.2014.94

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  • Endoscopic resection of a vocal cord polyp with a bipolar snare in a patient with cervical disc herniation. Reviewed

    Minamino H, Nagami Y, Tominaga K, Matsushita N, Sugimori S, Shiba M, Watanabe T, Iguchi H, Fujiwara Y, Arakawa T

    Clinical journal of gastroenterology   7 ( 2 )   136 - 9   2014.04( ISSN:1865-7257

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    DOI: 10.1007/s12328-014-0469-3

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  • Infliximab and/or immunomodulators inhibit immune responses to trivalent influenza vaccination in adults with inflammatory bowel disease Reviewed

    Hagihara Yoshie, Ohfuji Satoko, Watanabe Kenji, Yamagami Hirokazu, Fukushima Wakaba, Maeda Kazuhiro, Karnata Noriko, Sogawa Mitsue, Shiba Masatsugu, Tanigawa Tetsuya, Tominaga Kazunari, Watanabe Toshio, Fujiwara Yasuhiro, Hirota Yoshio, Arakawa Tetsuo

    JOURNAL OF CROHNS & COLITIS   8 ( 3 )   223 - 233   2014.03( ISSN:1873-9946

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    DOI: 10.1016/j.crohns.2013.08.008

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  • Anti-tumour necrosis factor agents reduce non-steroidal anti-inflammatory drug-induced small bowel injury in rheumatoid arthritis patients Reviewed

    Watanabe Toshio, Tanigawa Tetsuya, Shiba Masatsugu, Nadatani Yuji, Nagami Yasuaki, Sugimori Satoshi, Yamagami Hirokazu, Watanabe Kenji, Tominaga Kazunari, Fujiwara Yasuhiro, Koike Tatsuya, Arakawa Tetsuo

    GUT   63 ( 3 )   409 - 414   2014.03( ISSN:0017-5749

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    DOI: 10.1136/gutjnl-2013-304713

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  • Successful Treatment of Betamethasone Syrup on Autoimmune Esophagitis Reviewed

    Kohata Yukie, Fujiwara Yasuhiro, Kato Kunihiro, Tanaka Fumio, Yamagami Hirokazu, Tanigawa Tetsuya, Shiba Masatsugu, Watanabe Kenji, Watanabe Toshio, Tominaga Kazunari, Tateishi Chiharu, Tsuruta Daisuke, Arakawa Tetsuo

    AMERICAN JOURNAL OF GASTROENTEROLOGY   109 ( 3 )   451 - 453   2014.03( ISSN:0002-9270

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    DOI: 10.1038/ajg.2013.455

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  • Role of small intestinal bacterial overgrowth in severe small intestinal damage in chronic non-steroidal anti-inflammatory drug users Reviewed

    Muraki Motoko, Fujiwara Yasuhiro, Machida Hirohisa, Okazaki Hirotoshi, Sogawa Mitsue, Yamagami Hirokazu, Tanigawa Tetsuya, Shiba Masatsugu, Watanabe Kenji, Tominaga Kazunari, Watanabe Toshio, Arakawa Tetsuo

    SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY   49 ( 3 )   267 - 273   2014.03( ISSN:0036-5521

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    DOI: 10.3109/00365521.2014.880182

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  • Clinical Efficacy of Endoscopic Submucosal Dissection for Adenocarcinomas of the Esophagogastric Junction. Reviewed

    Nagami Y, Machida H, Shiba M, Obayashi T, Ominami M, Fukunaga S, Sugimori S, Yamagami H, Tanigawa T, Watanabe K, Watanabe T, Tominaga K, Fujiwara Y, Arakawa T

    Endoscopy international open   2 ( 1 )   E15 - 20   2014.03( ISSN:2364-3722

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    DOI: 10.1055/s-0034-1365276

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  • Preventive Effect of Rebamipide of Indomethacin-Induced Small Intestinal Injury: Possible Involvement of Modulation of Bacterial Flora via Upregulation of alpha-Defensin 5 Reviewed

    Tanigawa Tetsuya, Otani Koji, Watanabe Toshio, Nadatani Yuji, Yamagami Hirokazu, Shiba Masatsugu, Watanabe Kenji, Tominaga Kazunari, Fujiwara Yasuhiro, Arakawa Tetsuo

    DIGESTION   89 ( 1 )   86 - 86   2014( ISSN:0012-2823

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  • Rome III classification and characteristics of Japanese patients with functional dyspepsia Reviewed

    TOMINAGA Kazunari, FUJIKAWA Yoshiko, TANAKA Fumio, TANIGAWA Tetsuya, SHIBA Masatsugu, WATANABE Toshio, FUJIWARA Yasuhiro, ARAKAWA Tetsuo

    The Japanese Society of Gastroenterology, Nippon Shokakibyo Gakkai Zasshi   111 ( 6 )   1079 - 1087   2014

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    DOI: 10.11405/nisshoshi.111.1079

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  • Primary small intestinal mucosa-associated lymphoid tissue lymphoma diagnosed by balloon-assisted enteroscopy. Reviewed

    Nadatani Y, Tanigawa T, Fukunaga S, Kinoshita Y, Ominami M, Obayashi T, Morimoto K, Sogawa M, Yamagami H, Shiba M, Watanabe K, Watanabe T, Tominaga K, Fujiwara Y, Arakawa T

    Internal medicine (Tokyo, Japan)   53 ( 23 )   2671 - 4   2014( ISSN:0918-2918

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  • Eosinophilic esophagitis-like endoscopic findings in patients with erosive esophagitis Reviewed

    Fujiwara Yasuhiro, Tanigawa Tetsuya, Yamagami Hirokazu, Watanabe Kenji, Tominaga Kazunari, Watanabe Toshio, Arakawa Tetsuo

    ESOPHAGUS   10 ( 4 )   199 - 204   2013.12( ISSN:1612-9059

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    DOI: 10.1007/s10388-013-0383-7

  • High-Mobility Group Box 1 Inhibits Gastric Ulcer Healing through Toll-Like Receptor 4 and Receptor for Advanced Glycation End Products Reviewed

    Nadatani Yuji, Watanabe Toshio, Tanigawa Tetsuya, Ohkawa Fumikazu, Takeda Shogo, Higashimori Akira, Sogawa Mitsue, Yamagami Hirokazu, Shiba Masatsugu, Watanabe Kenji, Tominaga Kazunari, Fujiwara Yasuhiro, Takeuchi Koji, Arakawa Tetsuo

    PLOS ONE   8 ( 11 )   e80130   2013.11( ISSN:1932-6203

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    DOI: 10.1371/journal.pone.0080130

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  • Mesenchymal stem cells administered in the early phase of tumorigenesis inhibit colorectal tumor development in rats Reviewed

    Katsuno Takayuki, Ochi Masahiro, Tominaga Kazunari, Tanaka Fumio, Sogawa Mitsue, Tanigawa Tetsuya, Yamagami Hirokazu, Shiba Masatsugu, Watanabe Kenji, Watanabe Toshio, Fujiwara Yasuhiro, Arakawa Tetsuo

    日本酸化ストレス学会 JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION   53 ( 3 )   170 - 175   2013.11( ISSN:0912-0009

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    To investigate the differences between the effects of mesenchymal stem cells (MSCs) administered in the early and late phases of tumorigenesis, MSCs were isolated from bone marrow and colorectal tumors were produced by exposing 7-week-old F344 rats to 1,2-dimethylhydrazine and dextran sulfate sodium. We evaluated tumor number and volume (week 25), MSC localization, number of aberrant crypt foci (ACF), transforming growth factor (TGF)-β1 protein levels in the rectum after administration of MSCs (week 5 or 15), and the effects of MSC-conditioned medium on ACL15 cell proliferation. Administered MSCs labeled with PKH26 were observed in the rectum. Administered MSCs in the early phase (week 5) before tumor occurrence (week 12) significantly decreased tumor number and volume (1.5 vs 4 and 21 mm<sup>3</sup> vs 170 mm<sup>3</sup>; <i>p</i><0.01), but not administered MSCs in the late phase (week 15). Administered MSCs in the early phase reduced ACF number on days 14 and 35 (1.9 vs 4.1 and 3.7 vs 7.3; <i>p</i><0.01). Rectal TGF-β1 increased 1.3 fold on day 3, and MSC-conditioned medium containing TGF-β1 abundantly inhibited ACL15 cell proliferation. MSCs administered in the early phase but not late phase inhibited colorectal tumor development in a rat model.

    DOI: 10.3164/jcbn.13-68

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  • Spontaneously Occurring Widespread Laceration and Bleeding in a Patient with Gastric Sarcoidosis during an Endoscopic Examination Reviewed

    OBAYASHI Tomoko, TOMINAGA Kazunari, FUKUNAGA Shusei, NAGAMI Yasuaki, SUGIMORI Satoshi, TANIGAWA Tetsuya, SHIBA Masatsugu, WATANABE Toshio, FUJIWARA Yasuhiro, ARAKAWA Tetsuo

    Japan Gastroenterological Endoscopy Society, GASTROENTEROLOGICAL ENDOSCOPY   55 ( 9 )   "3102 - 8"   2013.09( ISSN:03871207

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    A 68-year-old woman had visited a medical clinic because of abdominal bloating. Endoscopic examination had shown diffuse granular lesions in the entire stomach. Histological examination of the lesions revealed non-caseous granulomas. After clinically differentiation such as various diseases such as Crohn's disease, tuberculosis, or histoplasmosis, she had been diagnosed as having gastric sarcoidosis. Esophagogastrodudenoscopy (EGD) had been performed once a year as an annual screening. During a follow-up EGD on April 2011, lacerations with bleeding spontaneously occurred at the lesser curvature from the middle to the upper parts of the stomach. Thus, she was admitted to our hospital. Three days later, follow-up EGD examination showed improvement in the gastric lesions, and she was discharged from our hospital. It is important to gently manipulate the scope without excessive air insufflation in patients with gastric sarcoidosis because of mucosal friability.

    DOI: 10.11280/gee.55.3102

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  • The association between nighttime reflux and sleep Reviewed

    FUJIWARA Yasuhiro, HIRAMOTO Keiko, PARK Narika, NAKAHARA Kenichi, KOHATA Yukie, TANIGAWA Tetsuya, WATANABE Kenji, TOMINAGA Kazunari, WATANABE Toshio, ARAKAWA Tetsuo

    The Japanese Society of Gastroenterology, Nippon Shokakibyo Gakkai Zasshi   110 ( 6 )   965 - 970   2013.06( ISSN:04466586

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    DOI: 10.11405/nisshoshi.110.965

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  • [The association between nighttime reflux and sleep]. Reviewed

    Fujiwara Y, Hiramoto K, Park N, Nakahara K, Kohata Y, Tanigawa T, Watanabe K, Tominaga K, Watanabe T, Arakawa T

    Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology   110 ( 6 )   965 - 70   2013.06( ISSN:0446-6586

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  • CLINICAL EFFICACY OF INFLIXIMAB IN PATIENTS WITH ULCERATIVE COLITIS Reviewed

    NOGUCHI Atsushi, WATANABE Kenji, TANIGAWA Tetsuya, TOMINAGA Kazunari, WATANABE Toshio, FUJIWARA Yasuhiro, ARAKAWA Tetsuo

    40 ( 1 )   44 - 46   2013.05( ISSN:09163301

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  • THE ROLE OF KLOTHO, AN AGING SUPPRESSOR, IN GASTRIC ULCER HEALING Reviewed

    TANIGAWA Tetsuya, WATANABE Toshio, NADATANI Yuji, OTANI Koji, SOGAWA Mitsue, YAMAGAMI Hirokazu, SHIBA Masatsugu, WATANABE Kenji, TOMINAGA Kazunari, FUJIWARA Yasuhiro, ARAKAWA Tetsuo

    40 ( 1 )   64 - 68   2013.05( ISSN:09163301

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  • Cytoglobin May Be Involved in the Healing Process of Gastric Mucosal Injuries in the Late Phase Without Angiogenesis Reviewed

    Tanaka Fumio, Tominaga Kazunari, Sasaki Eiji, Sogawa Mitsue, Yamagami Hirokazu, Tanigawa Tetsuya, Shiba Masatsugu, Watanabe Kenji, Watanabe Toshio, Fujiwara Yasuhiro, Kawada Norifumi, Yoshizato Katsutoshi, Arakawa Tetsuo

    DIGESTIVE DISEASES AND SCIENCES   58 ( 5 )   1198 - 1206   2013.05( ISSN:0163-2116

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    DOI: 10.1007/s10620-012-2514-8

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  • Risk factors for severe nonsteroidal anti-inflammatory drug-induced small intestinal damage Reviewed

    Watanabe Toshio, Tanigawa Tetsuya, Nadatani Yuji, Nagami Yasuaki, Sugimori Satoshi, Okazaki Hirotoshi, Yamagami Hirokazu, Watanabe Kenji, Tominaga Kazunari, Fujiwara Yasuhiro, Koike Tatsuya, Arakawa Tetsuo

    DIGESTIVE AND LIVER DISEASE   45 ( 5 )   390 - 395   2013.05( ISSN:1590-8658

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    DOI: 10.1016/j.dld.2012.12.005

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  • Rebamipide inhibits indomethacin-induced small intestinal injury: Possible involvement of intestinal microbiota modulation by upregulation of alpha-defensin 5 Reviewed

    Tanigawa Tetsuya, Watanabe Toshio, Otani Koji, Nadatani Yuji, Ohkawa Fumikazu, Sogawa Mitsue, Yamagami Hirokazu, Shiba Masatsugu, Watanabe Kenji, Tominaga Kazunari, Fujiwara Yasuhiro, Takeuchi Koji, Arakawa Tetsuo

    EUROPEAN JOURNAL OF PHARMACOLOGY   704 ( 1-3 )   64 - 69   2013.03( ISSN:0014-2999

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    DOI: 10.1016/j.ejphar.2013.02.010

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  • Endoscopic radial incision and cutting method for refractory esophageal stricture after endoscopic submucosal dissection of superficial esophageal carcinoma Reviewed

    Minamino Hiroaki, Machida Hirohisa, Tominaga Kazunari, Sugimori Satoshi, Okazaki Hirotoshi, Tanigawa Tetsuya, Yamagami Hirokazu, Watanabe Kenji, Watanabe Toshio, Fujiwara Yasuhiro, Arakawa Tetsuo

    DIGESTIVE ENDOSCOPY   25 ( 2 )   200 - 203   2013.03( ISSN:0915-5635

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    DOI: 10.1111/j.1443-1661.2012.01348.x

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  • Incidence and risk factors of gastrointestinal bleeding in patients on low-dose aspirin therapy after percutaneous coronary intervention in Japan Reviewed

    Nadatani Yuji, Watanabe Toshio, Tanigawa Tetsuya, Sogawa Mitsue, Yamagami Hirokazu, Shiba Masatsugu, Watanabe Kenji, Tominaga Kazunari, Fujiwara Yasuhiro, Yoshiyama Minoru, Arakawa Tetsuo

    SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY   48 ( 3 )   320 - 325   2013.03( ISSN:0036-5521

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    DOI: 10.3109/00365521.2012.758771

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  • [Functional gastrointestinal disorders (FGID): progress in diagnosis and treatments. Topic III. Recent topics; 1. Promising pharmacological therapy for FGID in the future]. Reviewed

    Tominaga K, Fujikawa Y, Tanaka F, Sogawa M, Yamagami H, Tanigawa T, Shiba M, Watanabe K, Watanabe T, Fujiwara Y, Arakawa T

    Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine   102 ( 1 )   96 - 104   2013.01( ISSN:0021-5384

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  • Promising pharmacological therapy for FGID in the future Reviewed

    TOMINAGA Kaztunari, FUJIKAWA Yoshiko, TANAKA Fumio, SOGAWA Mitsue, YAMAGAMI Hirokazu, TANIGAWA Tetsuya, SHIBA Masatsugu, WATANABE Kenji, WATANABE Toshio, FUJIWARA Yasuhiro, ARAKAWA Tetsuo

    The Japanese Society of Internal Medicine, Nihon Naika Gakkai Zasshi   102 ( 1 )   96 - 104   2013.01( ISSN:00215384

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    DOI: 10.2169/naika.102.96

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  • Clinical Classification of Subgroups According to the Rome III Criteria Cannot be Used to Distinguish the Associated Respective Pathophysiology in Japanese Patients with Functional Dyspepsia Reviewed

    Ochi Masahiro, Tominaga Kazunari, Tanaka Fumio, Tanigawa Tetsuya, Yamagami Hirokazu, Watanabe Kenji, Watanabe Toshio, Fujiwara Yasuhiro, Arakawa Tetsuo

    一般社団法人 日本内科学会 INTERNAL MEDICINE   52 ( 12 )   1289 - 1293   2013( ISSN:0918-2918

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    <b>Objective</b> Patients who meet the Rome III criteria for functional dyspepsia (FD) are generally classified into the following two subgroups, those with postprandial distress syndrome (PDS) and those with epigastric pain syndrome (EPS), in order to treat the dyspeptic symptoms caused by the respective pathophysiological conditions. However, whether simple classification of FD can accurately distinguish the pathophysiological differences between PDS and EPS remains to be clarified because the pathophysiology of FD is characterized and complicated by various factors.<br> <b>Methods</b> After classifying FD patients who were not receiving medication at the initial visit, we assessed and compared the following pathophysiological factors between the PDS and EPS groups: (1) the gastric reservoir and emptying functions using a radioisotope method (n=75), (2) the autonomic nervous system (ANS) function using electrocardiography (n=45), (3) gastric mucosal atrophy and intestinal metaplasia using histological examinations (n=47), (4) endoscopic findings of the stomach, such as superficial changes, abnormal gastroesophageal flap valves (n=67) and (5) <i>Helicobacter pylori</i> infection (n=48).<br> <b>Results</b> The FD patients exhibited higher rates of an impaired reservoir function (49.3%), gastric emptying disorders (54.7%) and relative hyperactivity of the sympathetic nervous system (31.9%) than the control subjects. However, endoscopic and histological changes of the stomach were similar in both the FD patients and control subjects. In addition, no differences were observed in the above-mentioned factors between the PDS and EPS groups.<br> <b>Conclusion</b> The simple classification of FD patients into two subgroups according to the Rome III criteria following diagnosis does not indicate any differences in the pathophysiology related to the respective dyspeptic symptoms of FD patients.<br>

    DOI: 10.2169/internalmedicine.52.9205

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  • Structure of gastric glial cells and stress response Reviewed

    Fujikawa Yoshiko, Tominaga Kazunari, Tanaka Fumio, Watanabe Toshio, Fujiwara Yasuhiro, Arakawa Tetsuo

    Japanese Society of Psychosomatic Medicine on Digestive Diseases, Journal of Psychosomatic Medicine on Digestive Diseases   20 ( 1 )   30 - 32   2013

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    DOI: 10.11415/jpdd.20.30

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  • Precise Endoscopic and Pathologic Features in a Crohn's Disease Case with Two Fistula-associated Small Bowel Adenocarcinomas Complicated by an Anal Canal Adenocarcinoma Reviewed

    Sogawa Mitsue, Watanabe Kenji, Egashira Yutaro, Maeda Kiyoshi, Morimoto Kenichi, Noguchi Atsushi, Kamata Noriko, Yamagami Hirokazu, Watanabe Toshio, Tominaga Kazunari, Fujiwara Yasuhiro, Oshitani Nobuhide, Arakawa Tetsuo

    一般社団法人 日本内科学会 INTERNAL MEDICINE   52 ( 4 )   445 - 449   2013( ISSN:0918-2918

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    The patient was a 40-year-old man who had suffered from Crohn's disease (CD) for 19 years and developed an intractable perianal fistula and two strictures in the small bowel. Dilatation of the two strictures using double-balloon endoscopy did not improve the subileus symptoms. An anal canal adenocarcinoma was also detected using double-balloon endoscopy. The ileum and rectoperianal area were partially resected, and a precise immunohistochemical pathologic assessment revealed that all three lesions were fistula-associated adenocarcinomas. Accumulating endoscopic findings of CD-associated cancer and precise pathologic diagnostic findings will help to establish a suitable surveillance method.<br>

    DOI: 10.2169/internalmedicine.52.9021

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  • Toll-like receptor 9 signaling has anti-inflammatory effects on the early phase of Helicobacter pylori-induced gastritis Reviewed

    Otani Koji, Tanigawa Tetsuya, Watanabe Toshio, Nadatani Yuji, Sogawa Mitsue, Yamagami Hirokazu, Shiba Masatsugu, Watanabe Kenji, Tominaga Kazunari, Fujiwara Yasuhiro, Arakawa Tetsuo

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   426 ( 3 )   342 - 349   2012.09( ISSN:0006-291X

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    DOI: 10.1016/j.bbrc.2012.08.080

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  • Quality of ulcer healing in gastrointestinal tract: Its pathophysiology and clinical relevance Reviewed

    Arakawa Tetsuo, Watanabe Toshio, Tanigawa Tetsuya, Tominaga Kazunari, Fujiwara Yasuhiro, Morimoto Ken'ichi

    WORLD JOURNAL OF GASTROENTEROLOGY   18 ( 35 )   4811 - 4822   2012.09( ISSN:1007-9327

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    DOI: 10.3748/wjg.v18.i35.4811

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  • Activation of the MyD88 signaling pathway inhibits ischemia-reperfusion injury in the small intestine Reviewed

    Watanabe Toshio, Kobata Atsushi, Tanigawa Tetsuya, Nadatani Yuji, Yamagami Hirokazu, Watanabe Kenji, Tominaga Kazunari, Fujiwara Yasuhiro, Takeuchi Koji, Arakawa Tetsuo

    AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY   303 ( 3 )   G324 - G334   2012.08( ISSN:0193-1857

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    DOI: 10.1152/ajpgi.00075.2012

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  • Complete Remission of Protein-Losing Gastroenteropathy Associated With Sjogren's Syndrome by B Cell-Targeted Therapy With Rituximab Reviewed

    Uraoka Yoshika, Tanigawa Tetsuya, Watanabe Kimihiko, Machida Hirohisa, Okazaki Hirotoshi, Yamagami Hirokazu, Watanabe Kenji, Tominaga Kazunari, Watanabe Toshio, Fujiwara Yasuhiro, Arakawa Tetsuo

    AMERICAN JOURNAL OF GASTROENTEROLOGY   107 ( 8 )   1266 - 1268   2012.08( ISSN:0002-9270

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    DOI: 10.1038/ajg.2012.92

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  • High Mobility Group Box 1 Promotes Small Intestinal Damage Induced by Nonsteroidal Anti-Inflammatory Drugs through Toll-Like Receptor 4 Reviewed

    Nadatani Yuji, Watanabe Toshio, Tanigawa Tetsuya, Machida Hirohisa, Okazaki Hirotoshi, Yamagami Hirokazu, Watanabe Kenji, Tominaga Kazunari, Fujiwara Yasuhiro, Arakawa Tetsuo

    AMERICAN JOURNAL OF PATHOLOGY   181 ( 1 )   98 - 110   2012.07( ISSN:0002-9440

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    DOI: 10.1016/j.ajpath.2012.03.039

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  • Locoregional mitomycin C injection for esophageal stricture after endoscopic submucosal dissection Reviewed

    Machida H., Tominaga K., Minamino H., Sugimori S., Okazaki H., Yamagami H., Tanigawa T., Watanabe K., Watanabe T., Fujiwara Y., Arakawa T.

    ENDOSCOPY   44 ( 6 )   622 - 625   2012.06( ISSN:0013-726X

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    DOI: 10.1055/s-0032-1306775

  • INHIBITORY EFFECT OF REBAMIPIDE ON INDOMETHACIN-INDUCED SMALL INTESTINAL INJURY : POSSIBLE MECHANISM VIA MODULATION OF BACTERIAL FLORA THROUGH DEFENSIN UPREGULATION Reviewed

    TANIGAWA Tetsuya, OTANI Koji, WATANABE Toshio, NADATANI Yuji, MACHIDA Hirohisa, OKAZAKI Hirotoshi, YAMAGAMI Hirokazu, WATANABE Kenji, TOMINAGA Kazunari, FUJIWARA Yasuhiro, ARAKAWA Tetsuo

    39 ( 1 )   94 - 97   2012.05( ISSN:09163301

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  • THE INCIDENCE AND THE RISK FACTOR OF GASTROINTESTINAL BLEEDING IN PATIENT UNDERGOING LOW-DOSE ASPIRIN THERAPY FOLLOWING PERCUTANEOUS CORONARY INTERVENTION Reviewed

    NADATANI Yuji, WATANABE Toshio, TANIGAWA Tetsuya, OTANI Koji, MACHIDA Hirohisa, OKAZAKI Hirotoshi, YAMAGAMI Hirokazu, WATANABE Kenji, TOMINAGA Kazunari, FUJIWARA Yasuhiro, ARAKAWA Tetsuo

    39 ( 1 )   42 - 46   2012.05( ISSN:09163301

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  • The Optimum Interval Period of an Appropriate Management for Gastrointestinal Mesenchymal Tumors (GIMTs) on the Basis of Tumor Growth Reviewed

    Sugimori Satoshi, Tominaga Kazunari, Onishi Miho, Nagami Yasuaki, Machida Hirohisa, Okazaki Hirotoshi, Tanigawa Tetsuya, Watanabe Toshio, Fujiwara Yasuhiro, Arakawa Tetsuo

    GASTROINTESTINAL ENDOSCOPY   75 ( 4 )   435 - 435   2012.04( ISSN:0016-5107

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  • Short- and Long-Term Prognosis of Patients With Early Gastric Cancer: Comparative Analysis Between Endoscopic Submucosal Dissection and Surgical Operation Reviewed

    Fukunaga Shusei, Machida Hirohisa, Tominaga Kazunari, Tanaka Hiroaki, Muguruma Kazuya, Ohira Masaichi, Nagami Yasuaki, Sugimori Satoshi, Okazaki Hirotoshi, Tanigawa Tetsuya, Yamagami Hirokazu, Watanabe Kenji, Watanabe Toshio, Fujiwara Yasuhiro, Hirakawa Kosei, Arakawa Tetsuo

    GASTROINTESTINAL ENDOSCOPY   75 ( 4 )   234 - 235   2012.04( ISSN:0016-5107

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  • Internal hypoechoic feature by EUS as a possible predictive marker for the enlargement potential of gastric GI stromal tumors Reviewed

    Onishi Miho, Tominaga Kazunari, Sugimori Satoshi, Machida Hirohisa, Okazaki Hirotoshi, Yamagami Hirokazu, Tanigawa Tetsuya, Watanabe Kenji, Watanabe Toshio, Fujiwara Yasuhiro, Arakawa Tetsuo

    GASTROINTESTINAL ENDOSCOPY   75 ( 4 )   731 - 738   2012.04( ISSN:0016-5107

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    DOI: 10.1016/j.gie.2011.10.036

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  • The Prevalence of Various Complications Associated With Double-Balloon Endoscopy Reviewed

    Nakayama Sayoko, Tominaga Kazunari, Obayashi Tomoko, Okamoto Junichi, Minamino Hiroaki, Ominami Masaki, Fukunaga Shusei, Nagami Yasuaki, Sugimori Satoshi, Machida Hirohisa, Okazaki Hirotoshi, Yamagami Hirokazu, Tanigawa Tetsuya, Watanabe Kenji, Watanabe Toshio, Fujiwara Yasuhiro, Arakawa Tetsuo

    GASTROINTESTINAL ENDOSCOPY   75 ( 4 )   255 - 255   2012.04( ISSN:0016-5107

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  • Final Result of a Prospective Non-Randomized Study for Accuracy of Detection and Diagnosis of Esophageal Squamous Cell Carcinoma by Tandem Non-Magnifying Endoscopy With Narrow-Band Imaging and Iodine Staining Reviewed

    Nagami Yasuaki, Machida Hirohisa, Tominaga Kazunari, Nakatani Masami, Kameda Natsuhiko, Sugimori Satoshi, Okazaki Hirotoshi, Tanigawa Tetsuya, Kubo Naoshi, Shiba Masatsugu, Watanabe Kenji, Watanabe Toshio, Fujiwara Yasuhiro, Ohira Masaichi, Arakawa Tetsuo

    GASTROINTESTINAL ENDOSCOPY   75 ( 4 )   169 - 169   2012.04( ISSN:0016-5107

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  • Is It Possible to Predict the Enlargement Potential of Gastric GISTs by the Internal Hypoechoic Feature At Initial EUS Examination? Reviewed

    Onishi Miho, Tominaga Kazunari, Sugimori Satoshi, Machida Hirohisa, Okazaki Hirotoshi, Yamagami Hirokazu, Tanigawa Tetsuya, Watanabe Kenji, Watanabe Toshio, Fujiwara Yasuhiro, Arakawa Tetsuo

    GASTROINTESTINAL ENDOSCOPY   75 ( 4 )   442 - 442   2012.04( ISSN:0016-5107

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  • Pathogenesis of proton-pump inhibitor-refractory non-erosive reflux disease according to multichannel intraluminal impedance-pH monitoring Reviewed

    Kohata Yukie, Fujiwara Yasuhiro, Machida Hirohisa, Okazaki Hirotoshi, Yamagami Hirokazu, Tanigawa Tetsuya, Watanabe Kenji, Watanabe Toshio, Tominaga Kazunari, Arakawa Tetsuo

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   27   58 - 62   2012.04( ISSN:0815-9319

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    DOI: 10.1111/j.1440-1746.2012.07074.x

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  • Clinical Feasibility and Safety of Modified Neuroleptanalgesia With Midazolam and Pethidine Hydrochloride in Endoscopic Submucosal Dissection for Esophageal Squamous Cell Carcinoma Reviewed

    Ominami Masaki, Machida Hirohisa, Tominaga Kazunari, Minamino Hiroaki, Nakayama Sayoko, Fukunaga Shusei, Nagami Yasuaki, Sugimori Satoshi, Okazaki Hirotoshi, Yamagami Hirokazu, Tanigawa Tetsuya, Watanabe Kenji, Watanabe Toshio, Fujiwara Yasuhiro, Arakawa Tetsuo

    GASTROINTESTINAL ENDOSCOPY   75 ( 4 )   465 - 466   2012.04( ISSN:0016-5107

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  • Small Intestinal Injury Caused by NSAIDs/Aspirin: Finding New from Old Reviewed

    Arakawa T., Watanabe T., Tanigawa T., Tominaga K., Otani K., Nadatani Y., Fujiwara Y.

    CURRENT MEDICINAL CHEMISTRY   19 ( 1 )   77 - 81   2012.01( ISSN:0929-8673

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  • The Successful Attempt to Perform ESD for Low Grade Dysplasia in Patients with Ulcerative Colitis Reviewed

    Morimoto Kenichi, Watanabe K., Ajioka Y., Nishishita M., Noguchi A., Sugimori S., Kamata N., Sogawa M., Machida H., Okazaki H., Yamagami H., Tanigawa T., Tominaga K., Watanabe T., Fujiwara Y., Arakawa T.

    DIGESTION   85 ( 2 )   168 - 168   2012( ISSN:0012-2823

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  • A Multicenter Study on the Prevalence of Eosinophilic Esophagitis and PPI-Responsive Esophageal Eosinophilic Infiltration Reviewed

    Fujiwara Yasuhiro, Sugawa Takashi, Tanaka Fumio, Tatsuwaki Hiroshi, Okuyama Masatsugu, Hayakawa Tsuyoshi, Yamamori Kazuki, Wada Rikimon, Ohtani Kenjiro, Uno Hironori, Tanigawa Tetsuya, Watanabe Yoshihisa, Tominaga Kazunari, Watanabe Toshio, Takaishi Osamu, Saeki Yoshihiko, Nebiki Hiroko, Oshitani Nobuhide, Sato Hiroshi, Arakawa Tetsuo

    一般社団法人 日本内科学会 INTERNAL MEDICINE   51 ( 23 )   3235 - 3239   2012( ISSN:0918-2918

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    <b>Objective</b> Eosinophilic esophagitis (EoE) is diagnosed by the presence of dysphagia and intraepithelial eosinophilic infiltration of &ge;15 per high-power field (HPF). EoE should be distinguished from proton pump inhibitor-responsive esophageal eosinophilic infiltration (PPI-R EEI) in patients that are responsive to PPI treatment. The aim of this study was to determine the prevalence of EoE and PPI-R EEI in Japanese patients in a multicenter study.<br> <b>Methods</b> Ten hospitals participated in this study. Esophageal biopsy was performed when the patients had typical EoE symptoms or when endoscopic findings revealed a typical EoE appearance. EEI was defined as the intraepithelial eosinophilic infiltration of &ge;15 per HPF. Patients with EEI received rabeprazole for 8 weeks to distinguish EoE from PPI-R EEI.<br> <b>Results</b> A total of 13,634 subjects that underwent upper gastrointestinal endoscopy because of further examination or as a routine checkup were enrolled. Seventy-one (0.5%) patients suspected with EoE were examined by biopsy. A histological examination of 7 (9.9%) cases revealed EEI. Two of these 7 patients showed no symptoms and the other 5 were treated with PPI. Two (0.01%) patients were diagnosed with EoE and 3 (0.02%) with PPI-R EEI.<br> <b>Conclusion</b> EoE and PPI-R EEI were rare in Japanese patients that underwent upper gastrointestinal endoscopy.<br>

    DOI: 10.2169/internalmedicine.51.8670

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  • High Prevalence of Gastroesophageal Reflux Symptoms in Patients with Non-Alcoholic Fatty Liver Disease Associated with Serum Levels of Triglyceride and Cholesterol but Not Simple Visceral Obesity Reviewed

    Fujikawa Yoshiko, Tominaga Kazunari, Fujii Hideki, Machida Hirohisa, Okazaki Hirotoshi, Yamagami Hirokazu, Tanigawa Tetsuya, Watanabe Kenji, Watanabe Toshio, Fujiwara Yasuhiro, Matsuura Toshifumi, Kawada Norifumi, Arakawa Tetsuo

    DIGESTION   86 ( 3 )   228 - 237   2012( ISSN:0012-2823

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    DOI: 10.1159/000341418

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  • The Usefulness of Double-balloon Enteroscopy in Gastrointestinal Stromal Tumors of the Small Bowel with Obscure Gastrointestinal Bleeding Reviewed

    Nakatani Masami, Fujiwara Yasuhiro, Nagami Yasuaki, Sugimori Satoshi, Kameda Natsuhiko, Machida Hirohisa, Okazaki Hirotoshi, Yamagami Hirokazu, Tanigawa Tetsuya, Watanabe Kenji, Watanabe Toshio, Tominaga Kazunari, Noda Eiji, Maeda Kiyoshi, Ohsawa Masahiko, Wakasa Kenichi, Hirakawa Kosei, Arakawa Tetsuo

    一般社団法人 日本内科学会 INTERNAL MEDICINE   51 ( 19 )   2675 - 2682   2012( ISSN:0918-2918

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    <b>Objective</b> Gastrointestinal stromal tumors (GISTs) are the most frequently occurring mesenchymal tumors of the GI tract. Double-balloon enteroscopy (DBE) and capsule endoscopy (CE) promise the detection and accurate diagnosis of small bowel diseases in patients with obscure GI bleeding (OGIB). The aim of the present study was to analyze the clinical characteristics of small bowel GISTs and the usefulness of DBE, CE and computed tomography (CT).<br> <b>Methods</b> Among 705 cases with OGIB examined between December 2003 and January 2011, 12 (1.7%) cases of small bowel GIST were identified. We analyzed endoscopic appearance, tumor-size and location, detection rate by DBE, CE and CT and clinical course in each of these cases.<br> <b>Results</b> Of the 12 patients with GIST, eight were men. The mean patient age was 53.6 years. The presenting symptoms in most patients included tarry stools and/or anemia. Six patients required blood transfusions. The detection rates of DBE, CE and CT were 92%, 60% and 67%, respectively. All cases, except for one incomplete study, were identified using DBE; however, one case was not diagnosed as a tumor because of the presence of extramural growth. A pathological diagnosis of GIST was obtained using biopsies during DBE in three (45%) of seven cases. Lower detection rates were found in cases with intramural and extramural growth, larger tumors (&ge;35 mm) detected by CE and intraluminal growth and smaller tumors (<35 mm) detected by CT.<br> <b>Conclusion</b> DBE or a combination of CE and CT are thus considered to be useful for detecting small bowel GISTs.<br>

    DOI: 10.2169/internalmedicine.51.7847

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  • [Pathophysiology and treatment of drug-induced injury in gastrointestinal tract]. Reviewed

    Arakawa T, Fujiwara Y, Tominaga K, Watanabe T, Tanigawa T

    Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine   100 ( 12 )   3655 - 63   2011.12( ISSN:0021-5384

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  • Pathophysiology and treatment of drug-induced injury in gastrointestinal tract Reviewed

    ARAKAWA Tetsuo, FUJIWARA Yasuhiro, TOMINAGA Kazunari, WATANABE Toshio, TANIGAWA Tetsuya

    The Japanese Society of Internal Medicine, Nihon Naika Gakkai Zasshi   100 ( 12 )   3655 - 3663   2011.12( ISSN:00215384

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    DOI: 10.2169/naika.100.3655

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  • A CASE REPORT OF EOSINOPHILIC ESOPHAGITIS WITH A STRICTURE SUCCESSFULLY TREATED USING FLUTICASONE SWALLOWING THERAPY Reviewed

    FUJIWARA Yasuhiro, MURAKI Motoko, KOHATA Yukie, SUGIMORI Satoshi, YAMAGAMI Hirokazu, TANIGAWA Tetsuya, WATANABE Kenji, WATANABE Toshio, TOMINAGA Kazunari, ARAKAWA Tetsuo

    Japan Gastroenterological Endoscopy Society, GASTROENTEROLOGICAL ENDOSCOPY   53 ( 11 )   3523 - 3528   2011.11( ISSN:03871207

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    A 31-year-old woman was referred to our department because of dysphagia and food impaction for more than 6 years. Upper gastrointestinal endoscopy revealed a marked stricture at the esophagogastric junction without tumor. Endosonography revealed mucosal thickening of the esophagus and pathological examination of biopsied specimens showed marked infiltration of eosinophils (&ge;100/high-power field, HPF) and microabscess in the esophageal epithelium. Blood chemistry revealed an increase in the number of peripheral eosinophils and total immunoglobulin E (IgE) levels, and patch tests were positive for foods, including eggs and fish. The diagnosis of eosinophilic esophagitis was confirmed on the basis of the clinical symptoms and endoscopic and pathological findings. The patient was started on fluticasone swallowing therapy. Improvement in the symptoms, stricture, and histology was noted 2 months after the topical steroid therapy.

    DOI: 10.11280/gee.53.3523

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  • A CASE OF DELAYED PERFORATION OF A GASTRIC ULCER INDUCED BY ENDOSCOPIC SUBMUCOSAL DISSECTION FOR EARLY GASTRIC CANCER Reviewed

    KATO Kunihiro, TOMINAGA Kazunari, NAGAMI Yasuaki, MACHIDA Hirohisa, OKAZAKI Hirotoshi, TANIGAWA Tetsuya, WATANABE Toshio, FUJIWARA Yasuhiro, OHSAWA Masahiko, ARAKAWA Tetsuo

    Japan Gastroenterological Endoscopy Society, GASTROENTEROLOGICAL ENDOSCOPY   53 ( 10 )   3280 - 3285   2011.10( ISSN:03871207

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    Under a follow-up after a treatment of peptic ulcer of the stomach, a 64-year-old male underwent endoscopic submucosal dissection (ESD) for an early gastric cancer at a different site from the ulcer. He was followed by administration of proton pump inhibitor (PPI) for three weeks without symptoms. However he underwent emergency surgery 49 days after the ESD because of perforation at the site of ulceration, induced by the ESD. Despite some findings of healing of the gastric ulcer on the pathology report, the ulcer had reached the muscle layers and perforated. The reason for the delayed perforation was possibly due to the interruption of the PPI, and the effect of the PPI was not enough to decrease acid secretion because the PPI was rapidly metabolized.

    DOI: 10.11280/gee.53.3280

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  • PATHOGENESIS AND TREATMENT STRATEGY OF PPI-REFRACTORY NON-EROSIVE REFLUX DISEASE BY USING MULTICHANNEL INTRALUMINAL IMPEDANCE-pH MONITORING Reviewed

    KOHATA Yukie, FUJIWARA Yasuhiro, MACHIDA Hirohisa, OKAZAKI Hirotoshi, YAMAGAMI Hirokazu, TANIGAWA Tetsuya, WATANABE Kenji, WATANABE Toshio, TOMINAGA Kazunari, ARAKAWA Tetsuo

    38 ( 2 )   166 - 169   2011.09( ISSN:09163301

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  • CHEMOKINE RECEPTOR EXPRESSION ON PERIPHERAL IMMATURE PLASMA CELLS IN PATIENTS WITH ULCERATIVE COLITIS Reviewed

    HOSOMI Shuhei, WATANABE Kenji, SHINDO Masayoshi, TSUKAHARA Takuya, ITO Yoshie, MORIMOTO Kenichi, KAMEDA Natsuhiko, KAMATA Noriko, MACHIDA Hirohisa, OKAZAKI Hirotoshi, SOGAWA Mitsue, YAMAGAMI Hirokazu, TOMINAGA Kazunari, WATANABE Toshio, FUJIWARA Yasuhiro, ARAKAWA Tetsuo

    38 ( 2 )   139 - 141   2011.09( ISSN:09163301

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  • 実験潰瘍懇話会から日本潰瘍学会まで : 温故治新 Reviewed

    荒川 哲男, 竹本 忠良, 小林 絢三, 桑山 肇, 渡辺 俊雄

    潰瘍 = Ulcer research   38 ( 2 )   iii - x   2011.09( ISSN:09163301

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  • Role of Th-2 cytokines in the development of Barrett's esophagus in rats Reviewed

    KOHATA Yukie, FUJIWARA Yasuhiro, MACHIDA Hirohisa, OKAZAKI Hirotoshi, YAMAGAMI Hirokazu, TANIGAWA Tetsuya, WATANABE Kenji, WATANABE Toshio, TOMINAGA Kazunari, WEI Min, WANIBUCHI Hideki, ARAKAWA Tetsuo

    Journal of gastroenterology   46 ( 7 )   883 - 893   2011.07( ISSN:09441174

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  • Risk Factors Associated With Dyspepsia in Japanese Adults Reviewed

    Fujiwara Yasuhiro, Kubo Makiko, Kohata Yukie, Yamagami Hirokazu, Tanigawa Tetsuya, Watanabe Kenji, Watanabe Toshio, Tominaga Kazunari, Arakawa Tetsuo

    JOURNAL OF CLINICAL GASTROENTEROLOGY   45 ( 6 )   567 - 568   2011.07( ISSN:0192-0790

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    DOI: 10.1097/MCG.0b013e31820c63a9

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  • [Efficacy of prostaglandin derivatives and mucoprotective drugs in treatment and prevention for NSAIDs-induced ulcer]. Reviewed

    Fujikawa Y, Watanabe T, Tominaga K, Fujiwara Y, Sato H, Arakawa T

    Nihon rinsho. Japanese journal of clinical medicine   69 ( 6 )   1039 - 43   2011.06( ISSN:0047-1852

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  • Dysregulated upregulation of T-cell immunoglobulin and mucin domain-3 on mucosal T helper 1 cells in patients with Crohn's disease Reviewed

    Morimoto Kenichi, Hosomi Shuhei, Yamagami Hirokazu, Watanabe Kenji, Kamata Noriko, Sogawa Mitsue, Machida Hirohisa, Okazaki Hirotoshi, Tanigawa Tetsuya, Nagahara Hisashi, Noda Eiji, Tominaga Kazunari, Watanabe Toshio, Fujiwara Yasuhiro, Maeda Kiyoshi, Hirakawa Kosei, Arakawa Tetsuo

    SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY   46 ( 6 )   701 - 709   2011.06( ISSN:0036-5521

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    DOI: 10.3109/00365521.2011.568518

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  • HIGH-MOBILITY GROUP BOX1 IS A PROMOTING FACTOR FOR SMALL INTESTINAL DAMAGE INDUCED BY NON-STEROIDAL ANTI-INFLAMMATORY DRUGS Reviewed

    NADATANI Yuji, WATANABE Toshio, TANIGAWA Tetsuya, OTANI Koji, MACHIDA Hirohisa, OKAZAKI Hirotoshi, YAMAGAMI Hirokazu, WATANABE Kenji, TOMINAGA Kazunari, FUJIWARA Yasuhiro, ARAKAWA Tetsuo

    38 ( 1 )   16 - 19   2011.05( ISSN:09163301

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  • REBAMIPIDE INHIBITS INDOMETHACIN-INDUCFD SMALL INTESTINAL INJURY THROUGH THE MODULATION OF BACTERIAL FLORA Reviewed

    OTANI Koji, TANIGAWA Tetsuya, WATANABE Toshio, NADATANI Yuji, MACHIDA Hirohisa, OKAZAKI Hirotoshi, YAMAGAMI Hirokazu, WATANABE Kenji, TOMINAGA Kazunari, FUJIWARA Yasuhiro, ARAKAWA Tetsuo

    38 ( 1 )   90 - 93   2011.05( ISSN:09163301

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  • Mitochondrial disorders in NSAIDs-induced small bowel injury Reviewed

    Watanabe Toshio, Tanigawa Tetsuya, Nadatani Yuji, Otani Koji, Machida Hirohisa, Okazaki Hirotoshi, Yamagami Hirokazu, Watanabe Kenji, Tominaga Kazunari, Fujiwara Yasuhiro, Arakawa Tetsuo

    日本酸化ストレス学会 JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION   48 ( 2 )   117 - 121   2011.03( ISSN:0912-0009

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    Recent studies using small bowel endoscopy revealed that non-steroidal anti-inflammatory drugs including low-dose aspirin, can often induce small bowel injury. Non-steroidal anti-inflammatory drugs-induced small bowel mucosal injury involves various factors such as enterobacteria, cytokines, and bile. Experimental studies demonstrate that both mitochondrial disorders and inhibition of cyclooxygenases are required for development of non-steroidal anti-inflammatory drugs-induced small bowel injury. Mitochondrion is an organelle playing a central role in energy production in organisms. Many non-steroidal anti-inflammatory drugs directly cause mitochondrial disorders, which are attributable to uncoupling of oxidative phosphorylation induced by opening of the mega channel called mitochondrial permeability transition pore on the mitochondrial membrane by non-steroidal anti-inflammatory drugs. Bile acids and tumor necrosis factor-&alpha; also can open the permeability transition pore. The permeability transition pore opening induces the release of cytochrome <i>c</i> from mitochondrial matrix into the cytosol, which triggers a cascade of events that will lead to cell death. Therefore these mitochondrial disorders may cause disturbance of the mucosal barrier function and elevation of the small bowel permeability, and play particularly important roles in early processes of non-steroidal anti-inflammatory drugs-induced small bowel injury. Although no valid means of preventing or treating non-steroidal anti-inflammatory drugs-induced small bowel injury has been established, advances in mitochondrial studies may bring about innovation in the prevention and treatment of this kind of injury.<br>

    DOI: 10.3164/jcbn.10-73

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  • Rebamipide, a mucoprotective drug, inhibits NSAIDs-induced gastric mucosal injury: possible involvement of the downregulation of 15-hydroxyprostaglandin dehydrogenase Reviewed

    Tanigawa Tetsuya, Watanabe Toshio, Ohkawa Fumikazu, Nadatani Yuji, Otani Koji, Machida Hirohisa, Okazaki Hirotoshi, Yamagami Hirokazu, Watanabe Kenji, Tominaga Kazunari, Fujiwara Yasuhiro, Takeuchi Koji, Arakawa Tetsuo

    日本酸化ストレス学会 JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION   48 ( 2 )   149 - 153   2011.03( ISSN:0912-0009

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    Prostaglandin E<sub>2</sub> plays an important role in the maintenance of gastric mucosal integrity. The level of biologically active prostaglandin E<sub>2</sub> in the tissue is regulated by the balanced expression of its synthetic enzymes, such as cyclooxygenase, and its catabolic enzyme, 15-hydroxyprostaglandin dehydrogenase. We examined the effect of rebamipide, a mucoprotective drug, on prostaglandin E<sub>2</sub> production and metabolism in the gastric tissue and its effect on indomethacin-induced gastric mucosal injury in mice. Rebamipide suppressed indomethacin-induced gastric mucosal injury. Suppressive effect of rebamipide on indomethacin-induced gastric mucosal injury was also observed in cyclooxygenase-2-knockout mice. The mice that were treated with rebamipide showed a 2-fold increase in cyclooxygenase-2 mRNA expression in the gastric tissue, whereas 15-hydroxyprostaglandin dehydrogenase mRNA expression markedly decreased as compared to vehicle-treated control mice. Rebamipide did not affect the expression of cyclooxygenase-1 in the gastric tissue. Rebamipide did not increase prostaglandin E<sub>2</sub> production in the gastric tissue; however, it induced a 1.4-fold increase in the concentration of prostaglandin E<sub>2</sub> in the gastric tissue as compared to vehicle-treated control mice. These results suggest that the suppressive effect of rebamipide on non-steroidal anti-inflammatory drugs-induced gastric mucosal injury can be attributed to reduced 15-hydroxyprostaglandin dehydrogenase expression, which increases the prostaglandin E<sub>2</sub> concentration in the gastric tissue.<br>

    DOI: 10.3164/jcbn.10-75

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  • Differences between risk factors among irritable bowel syndrome subtypes in Japanese adults Reviewed

    Kubo M., Fujiwara Y., Shiba M., Kohata Y., Yamagami H., Tanigawa T., Watanabe K., Watanabe T., Tominaga K., Arakawa T.

    NEUROGASTROENTEROLOGY AND MOTILITY   23 ( 3 )   249 - 254   2011.03( ISSN:1350-1925

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    DOI: 10.1111/j.1365-2982.2010.01640.x

  • A CASE REPORT ON PRIMARY GASTRIC ACTINOMYCOSIS Reviewed

    MINAMINO Hiroaki, MACHIDA Hirohisa, TOMINAGA Kazunari, KAMEDA Natsuhiko, OKAZAKI Hirotoshi, TANIGAWA Tetsuya, WATANABE Kenji, WATANABE Toshio, FUJIWARA Yasuhiro, OSAWA Masahiko, ARAKAWA Tetsuo

    Japan Gastroenterological Endoscopy Society, GASTROENTEROLOGICAL ENDOSCOPY   53 ( 2 )   262 - 269   2011.02( ISSN:03871207

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    Primary gastric actinomycosis is an extremely rare condition, and just over 20 cases have been reported in the literature. In most cases, the diagnosis was made by performing histopathological examination of surgical specimens. We report on a 37-year-old woman with B-cell prolymphocytic leukemia who underwent second-line chemotherapy. After 2 weeks, she developed nausea and epigastralgia. Esophagogastroduodenoscopy (EGD) revealed a large ulceration, mucosal edema, and thickening of the gastric lining. Histopathological examination of biopsy specimens obtained by endoscopy revealed actinomycotic granules with typical features of <I>Actinomyces </I>species. Gastric actinomycosis was diagnosed, and the patient underwent treatment with an intravenous dose of ABPC/SBT for 35 days and a subsequent oral dose of AMPC. EGD findings at 65 days after treatment revealed disappearance of both ulceration and thickening of the gastric mucosal lining. The patient was discharged, but the antibiotherapy was continued. A Definitive diagnosis of primary gastric actinomycosis wihtout surgical treatment is relatively difficult because there are no specific endoscopic findings for this condition ; the endoscopic findings may sometimes indicate a malignant tumor. Furthermore, histopathological examination of biopsy specimens may not often provide typical and suspicious findings of the disease. The ideal duration and selection of the standard antibiotherapy for actinomycosis have not yet been established. Antibiotherapy was continued for almost 6-12 months in the reported cases. We report this case on account of its rarity with regard to the diagnosis of primary gastric actinomycosis based on endoscopic findings and promising results of conservative therapy with antibiotics.

    DOI: 10.11280/gee.53.262

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  • 機能性ディスペプシア(FD)-ストレス・自律神経機能の視点より Reviewed

    富永 和作, 越智 正博, 谷川 徹也, 渡辺 俊雄, 藤原 靖弘, 荒川 哲男

    日本心療内科学会誌   15 ( 1 )   11 - 16   2011.02( ISSN:13429558

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  • Increased numbers of immature plasma cells in peripheral blood specifically overexpress chemokine receptor CXCR3 and CXCR4 in patients with ulcerative colitis Reviewed

    Hosomi S., Oshitani N., Kamata N., Sogawa M., Okazaki H., Tanigawa T., Yamagami H., Watanabe K., Tominaga K., Watanabe T., Fujiwara Y., Maeda K., Hirakawa K., Arakawa T.

    CLINICAL AND EXPERIMENTAL IMMUNOLOGY   163 ( 2 )   215 - 224   2011.02( ISSN:0009-9104

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    DOI: 10.1111/j.1365-2249.2010.04290.x

  • [The small bowel pathologies for overt bleeding]. Reviewed

    Watanabe K, Kamata N, Sogawa M, Kameda N, Tanigawa T, Yamagami H, Watanabe T, Tominaga K, Fujiwara Y, Arakawa T

    Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine   100 ( 1 )   58 - 64   2011.01( ISSN:0021-5384

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  • The small bowel pathologies for overt bleeding Reviewed

    WATANABE Kenji, KAMATA Noriko, SOGAWA Mitsue, KAMEDA Natsuhiko, TANIGAWA Tetsuya, YAMAGAMI Hirokazu, WATANABE Toshio, TOMINAGA Kazunari, FUJIWARA Yasuhiro, ARAKAWA Tetsuo

    The Japanese Society of Internal Medicine, Nihon Naika Gakkai Zasshi   100 ( 1 )   58 - 64   2011.01( ISSN:00215384

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    DOI: 10.2169/naika.100.58

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  • Association between Left-Handedness and Gastrointestinal Symptoms Reviewed

    Fujiwara Yasuhiro, Kubo Makiko, Kohata Yukie, Yamagami Hirokazu, Tanigawa Tetsuya, Watanabe Kenji, Watanabe Toshio, Tominaga Kazunari, Arakawa Tetsuo

    DIGESTION   84 ( 2 )   114 - 118   2011( ISSN:0012-2823

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    DOI: 10.1159/000324680

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  • Gastrointestinal Bleeding after Percutaneous Coronary Intervention Reviewed

    Tanigawa Tetsuya, Watanabe Toshio, Nadatani Yuji, Otani Koji, Machida Hirohisa, Okazaki Hirotoshi, Yamagami Hirokazu, Watanabe Kenji, Tominaga Kazunari, Fujiwara Yasuhiro, Arakawa Tetsuo

    DIGESTION   83 ( 3 )   153 - 160   2011( ISSN:0012-2823

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    DOI: 10.1159/000321813

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  • The Traditional Japanese Medicine Rikkunshito Promotes Gastric Emptying via the Antagonistic Action of the 5-HT3 Receptor Pathway in Rats Reviewed

    Tominaga K., Kido T., Ochi M., Sadakane C., Mase A., Okazaki H., Yamagami H., Tanigawa T., Watanabe K., Watanabe T., Fujiwara Y., Oshitani N., Arakawa T.

    EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE   1 - 8   2011( ISSN:1741-427X

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    DOI: 10.1093/ecam/nep173

  • Cigarette Smoking and its Association with Overlapping Gastroesophageal Reflux Disease, Functional Dyspepsia, or Irritable Bowel Syndrome Reviewed

    Fujiwara Yasuhiro, Kubo Makiko, Kohata Yukie, Machida Hirohisa, Okazaki Hirotoshi, Yamagami Hirokazu, Tanigawa Tetsuya, Watanabe Kenji, Watanabe Toshio, Tominaga Kazunari, Arakawa Tetsuo

    一般社団法人 日本内科学会 INTERNAL MEDICINE   50 ( 21 )   2443 - 2447   2011( ISSN:0918-2918

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    <b>Background</b> Gastroesophageal reflux disease (GERD), functional dyspepsia (FD), and irritable bowel syndrome (IBS) are common gastrointestinal diseases. Several studies have shown a significant occurrence of overlap among these 3 diseases. The purpose of this study was to examine the factors associated with such disease overlap in Japanese adults.<br> <b>Methods</b> We performed a cross-sectional study on Japanese workers who visited a clinic for a routine health check-up and asked them to fill out a self-report questionnaire. GERD was defined as episodes of heartburn and/or acid regurgitation at least once a week, and the diagnosis of FD and IBS was based on Rome III criteria. A logistic regression model was used to identify risk factors, and odds ratio (OR) was calculated with 95% confidence intervals (CIs).<br> <b>Results</b> Disease overlaps were found in 160 (6.0%) of the 2680 eligible subjects. Female gender was associated with GERD + IBS (OR=1.99; 95% CI, 1.06-3.75), and FD + IBS (OR=1.72; 95% CI, 1.03-2.85), and lower body mass index was negatively associated with FD + IBS (OR=0.54; 96% CI, 0.34-0.87). Cigarette smoking was a common factor associated with the overlaps: GERD + FD (OR=2.14; 95% CI, 1.22-3.76), GERD + IBS (OR=3.16; 95% CI, 1.75-3.71), FD + IBS (OR=2.26; 95% CI, 1.40-3.66), and GERD + FD + IBS (OR=4.08; 95% CI, 1.66-10.07). The associations between smoking habits and overlaps were stronger in smokers who smoked &ge;1 pack per day as compared to those who smoked <1 pack per day.<br> <b>Conclusion</b> Cigarette smoking was significantly associated with overlaps among GERD, FD, and IBS in Japanese adults.<br>

    DOI: 10.2169/internalmedicine.50.6012

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  • [Gastric ulcer in the elderly: general concept and clinical features]. Reviewed

    Kubo M, Tanigawa T, Machida H, Okazaki H, Yamagami H, Watanabe K, Watanabe T, Tominaga K, Fujiwara Y, Arakawa T

    Nihon rinsho. Japanese journal of clinical medicine   68 ( 11 )   1967 - 72   2010.11( ISSN:0047-1852

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  • Long-term Efficacy of Proton-Pump Inhibitors in Japanese Elderly Patients with Gastroesophageal Reflux Disease Reviewed

    Arakawa Tetsuo, Fujiwara Yasuhiro, Tominaga Kazunari, Watanabe Toshio

    AMERICAN JOURNAL OF GASTROENTEROLOGY   105   S6 - S6   2010.10( ISSN:0002-9270

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  • Angioleiomyoma of the small intestine detected by double-balloon enteroscopy Reviewed

    Nakatani Masami, Fujiwara Yasuhiro, Kameda Natsuhiko, Okazaki Hirotoshi, Watanabe Toshio, Tominaga Kazunari, Arakawa Tetsuo, Noda Eiji, Inoue Toru, Maeda Kiyoshi, Hirakawa Kosei, Wakasa Kenichi

    GASTROINTESTINAL ENDOSCOPY   72 ( 1 )   187 - 187   2010.07( ISSN:0016-5107

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    DOI: 10.1016/j.gie.2009.12.037

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  • Prevalence of overlaps between GERD, FD and IBS and impact on health-related quality of life Reviewed

    Kaji Makiko, Fujiwara Yasuhiro, Shiba Masatsugu, Kohata Yukie, Yamagami Hirokazu, Tanigawa Tetsuya, Watanabe Kenji, Watanabe Toshio, Tominaga Kazunari, Arakawa Tetsuo

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   25 ( 6 )   1151 - 1156   2010.06( ISSN:0815-9319

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    DOI: 10.1111/j.1440-1746.2010.06249.x

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  • NSAIDs ULCER : NEW ASPECTS BORN FROM OLD KNOWLEDGE Reviewed

    ARAKAWA Tetsuo, WATANABE Toshio, TANIGAWA Tetsuya, SUGIMORI Satoshi, OKAZAKI Hirotoshi, TOMINAGA Kazunari, FUJIWARA Yasuhiro

    37 ( 1 )   1 - 6   2010.05( ISSN:09163301

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  • REBAMIPIDE-MEDIATED INCREASE IN GASTRIC PROSTAGLANDIN E_2 LEVELS VIA REDUCED EXPRESSION OF 15-HYDROXYPROSTAGLANDIN DEHYDROGENASE : POSSIBLE MECHANISM OF MUCOPROTECTION IN GASTRIC TISSUES Reviewed

    TANIGAWA Tetsuya, OHKAWA Fumikazu, WATANABE Toshio, NADATANI Yuji, OTANI Koji, MACHIDA Hirohisa, OKAZAKI Hirotoshi, YAMAGAMI Hirokazu, WATANABE Kenji, TOMINAGA Kazunari, FUJIWARA Yasuhiro, TAKEUCHI Koji, ARAKAWA Tetsuo

    37 ( 1 )   85 - 88   2010.05( ISSN:09163301

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  • ROLE OF ENTERIC BACTERIA IN THE PATHOGENESIS OF NSAIDs-INDUCED SMALL INTESTINAL DAMAGE-EFFECT OF PROBIOTIC BACTERIA ON PREVENTION OF DAMAGE Reviewed

    WATANABE Toshio, TANIGAWA Tetsuya, YAMAGAMI Hirokazu, OKAZAKI Hirotoshi, WATANABE Kenji, TOMINAGA Kazunari, FUJIWARA Yasuhiro, ARAKAWA Tetsuo

    37 ( 1 )   12 - 14   2010.05( ISSN:09163301

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  • Photodynamic diagnosis of endoscopically invisible flat dysplasia in patients with ulcerative colitis by visualization using local 5-aminolevulinic acid-induced photosensitization Reviewed

    Watanabe Kenji, Hida Nobuyuki, Ajioka Yoichi, Hori Kazutoshi, Kamata Noriko, Sogawa Mitsue, Yamagami Hirokazu, Tominaga Kazunari, Watanabe Toshio, Fujiwara Yasuhiro, Matsumoto Takayuki, Arakawa Tetsuo

    GASTROINTESTINAL ENDOSCOPY   71 ( 6 )   1094 - 1096   2010.05( ISSN:0016-5107

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    DOI: 10.1016/j.gie.2009.10.016

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  • Sofalcone, a gastroprotective drug, promotes gastric ulcer healing following eradication therapy for Helicobacter pylori: A randomized controlled comparative trial with cimetidine, an H-2-receptor antagonist Reviewed

    Higuchi Kazuhide, Watanabe Toshio, Tanigawa Tetsuya, Tominaga Kazunari, Fujiwara Yasuhiro, Arakawa Tetsuo

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   25   S155 - S160   2010.05( ISSN:0815-9319

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    DOI: 10.1111/j.1440-1746.2010.06232.x

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  • Reduction of 15-hydroxyprostaglandin dehydrogenase expression is an independent predictor of poor survival associated with enhanced cell proliferation in gastric adenocarcinoma Reviewed

    Tatsuwaki Hiroshi, Tanigawa Tetsuya, Watanabe Toshio, Machida Hirohisa, Okazaki Hirotoshi, Yamagami Hirokazu, Shiba Masatsugu, Watanabe Kenji, Tominaga Kazunari, Fujiwara Yasuhiro, Oshitani Nobuhide, Muguruma Kazuya, Sawada Tetsuji, Hirakawa Kosei, Higuchi Kazuhide, Arakawa Tetsuo

    CANCER SCIENCE   101 ( 2 )   550 - 558   2010.02( ISSN:1347-9032

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    DOI: 10.1111/j.1349-7006.2009.01390.x

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  • Bile acids induce cdx2 expression through the farnesoid x receptor in gastric epithelial cells. Reviewed

    Xu Y, Watanabe T, Tanigawa T, Machida H, Okazaki H, Yamagami H, Watanabe K, Tominaga K, Fujiwara Y, Oshitani N, Arakawa T

    日本酸化ストレス学会 Journal of clinical biochemistry and nutrition   46 ( 1 )   81 - 6   2010.01( ISSN:0912-0009

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    Clinical and experimental studies showed that the reflux of bile into the stomach contributes to the induction of intestinal metaplasia of the stomach and gastric carcinogenesis. Caudal-type homeobox 2 (Cdx2) plays a key role in the exhibition of intestinal phenotypes by regulating the expression of intestine-specific genes such as goblet-specific gene mucin 2 (MUC2). We investigated the involvement of the farnesoid X receptor (FXR), a nuclear receptor for bile acids, in the chenodeoxycholic acid (CDCA)-induced expression of Cdx2 and MUC2 in normal rat gastric epithelial cells (RGM-1 cells). RGM-1 cells were treated with CDCA or GW4064, an FXR agonist, in the presence or absence of guggulsterone, an FXR antagonist. CDCA induced dose-dependent expression of Cdx2 and MUC2 at both the mRNA and protein levels. The maximum stimulation of Cdx2 and MUC2 mRNA induced by CDCA was observed at 3&nbsp;h and by 6&nbsp;h, respectively. GW4064 also induced expression of these molecules. The effects of CDCA and GW4064 on expression of Cdx2 and MUC2 were abolished by guggulsterone. These findings suggest that bile acids may induce gastric intestinal metaplasia and carcinogenesis through the FXR.<br>

    DOI: 10.3164/jcbn.09-71

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  • Bile Acids Induce Cdx2 Expression Through the Farnesoid X Receptor in Gastric Epithelial Cells Reviewed

    Xu Yingji, Watanabe Toshio, Tanigawa Tetsuya, Machida Hirohisa, Okazaki Hirotoshi, Yamagami Hirokazu, Watanabe Kenji, Tominaga Kazunari, Fujiwara Yasuhiro, Oshitani Nobuhide, Arakawa Tetsuo

    JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION   46 ( 1 )   81 - 86   2010.01( ISSN:0912-0009

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  • Sleep Dysfunction in Japanese Patients with Gastroesophageal Reflux Disease: Prevalence, Risk Factors, and Efficacy of Rabeprazole Reviewed

    Fujiwara Yasuhiro, Kohata Yukie, Kaji Makiko, Nebiki Hiroko, Yamasaki Tomoaki, Sasaki Eiji, Hayakawa Tsuyoshi, Machida Hirohisa, Tanigawa Tetsuya, Watanabe Kenji, Watanabe Toshio, Tominaga Kazunari, Arakawa Tetsuo

    DIGESTION   81 ( 3 )   135 - 141   2010( ISSN:0012-2823

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    DOI: 10.1159/000253849

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  • Leptin Promotes Gastric Ulcer Healing via Upregulation of Vascular Endothelial Growth Factor Reviewed

    Tanigawa Tetsuya, Watanabe Toshio, Otani Koji, Nadatani Yuji, Machida Hirohisa, Okazaki Hirotoshi, Yamagami Hirokazu, Watanabe Kenji, Tominaga Kazunari, Fujiwara Yasuhiro, Oshitani Nobuhide, Higuchi Kazuhide, Arakawa Tetsuo

    DIGESTION   81 ( 2 )   86 - 95   2010( ISSN:0012-2823

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    DOI: 10.1159/000243719

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  • A Case of Primary Malignant Lymphoma of the Esophagus Treated with CHOP-R Reviewed

    NAKATANI Masami, FUJIWARA Yasuhiro, NAGAMI Yasuaki, KAMEDA Natsuhiko, MACHIDA Hirohisa, OKAZAKI Hirotoshi, WATANABE Toshio, TOMINAGA Kazunari, OHSAWA Masahiko, ARAKAWA Tetsuo

    Japan Gastroenterological Endoscopy Society, GASTROENTEROLOGICAL ENDOSCOPY   51 ( 12 )   3070 - 3077   2009.12( ISSN:03871207

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    A 50-year-old man with appetite loss and high fever was admitted to our hospital. Endoscopic examination revealed anodular lesion covered with thick white coat. Biopsy findings confirmed diffuse large B-cell lymphoma. The patient was treated with combined immunochemotherapy consisting of rituximab plus cyclophosphamide, vincristine, adriablastin, and prednisone (CHOP-R). A complete response was achieved. The patient was disease-free at 10 months after treatement.

    DOI: 10.11280/gee.51.3070

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  • Dislocation of Rab13 and vasodilator-stimulated phosphoprotein in inactive colon epithelium in patients with Crohn's disease. Reviewed

    Ohira M, Oshitani N, Hosomi S, Watanabe K, Yamagami H, Tominaga K, Watanabe T, Fujiwara Y, Maeda K, Hirakawa K, Arakawa T

    International journal of molecular medicine   24 ( 6 )   829 - 35   2009.12( ISSN:1107-3756

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  • [Gastroenterology and FSS]. Reviewed

    Tominaga K, Ochi M, Watanabe T, Fujiwara Y, Arakawa T

    Nihon rinsho. Japanese journal of clinical medicine   67 ( 9 )   1731 - 40   2009.09( ISSN:0047-1852

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  • Probiotic Lactobacillus casei strain Shirota prevents indomethacin-induced small intestinal injury: involvement of lactic acid Reviewed

    Watanabe Toshio, Nishio Hikaru, Tanigawa Tetsuya, Yamagami Hirokazu, Okazaki Hirotoshi, Watanabe Kenji, Tominaga Kazunari, Fujiwara Yasuhiro, Oshitani Nobuhide, Asahara Takashi, Nomoto Koji, Higuchi Kazuhide, Takeuchi Koji, Arakawa Tetsuo

    AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY   297 ( 3 )   G506 - G513   2009.09( ISSN:0193-1857

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    DOI: 10.1152/ajpgi.90553.2008

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  • Present status and strategy of NSAIDs-induced small bowel injury Reviewed

    Higuchi Kazuhide, Umegaki Eiji, Watanabe Toshio, Yoda Yukiko, Morita Eijiro, Murano Mitsuyuki, Tokioka Satoshi, Arakawa Tetsuo

    JOURNAL OF GASTROENTEROLOGY   44 ( 9 )   879 - 888   2009.09( ISSN:0944-1174

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    DOI: 10.1007/s00535-009-0102-2

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  • Predictive Factors of Worsening of Esophageal Varices After Balloon-Occluded Retrograde Transvenous Obliteration in Patients With Gastric Varices Reviewed

    Elsamman Mahmoud K., Fujiwara Yasuhiro, Kameda Natsuhiko, Okazaki Hirotoshi, Tanigawa Tetsuya, Shiba Masatsugu, Tominaga Kazunari, Watanabe Toshio, Oshitani Nobuhide, Arafa Usama A., El-Sayed Adel A., Nakamura Kenji, Arakawa Tetsuo

    AMERICAN JOURNAL OF GASTROENTEROLOGY   104 ( 9 )   2214 - 2221   2009.09( ISSN:0002-9270

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    DOI: 10.1038/ajg.2008.140

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  • Novel Management of Chronic Idiopathic Intestinal Pseudo-Obstruction Reviewed

    Kamata Noriko, Oshitani Nobuhide, Suekane Takehisa, Sogawa Mitsue, Yamagami Hirokazu, Watanabe Kenji, Okazaki Hirotoshi, Watanabe Toshio, Tominaga Kazunari, Fujiwara Yasuhiro, Arakawa Tetsuo

    AMERICAN JOURNAL OF GASTROENTEROLOGY   104 ( 9 )   2360 - 2362   2009.09( ISSN:0002-9270

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    DOI: 10.1038/ajg.2009.283

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  • Long-term efficacy of Helicobacter pylori eradication in patients with idiopathic thrombocytopenic purpura: 7-year follow-up prospective study Reviewed

    Tsumoto C., Tominaga K., Okazaki H., Tanigawa T., Yamagami H., Watanabe K., Nakao T., Koh K., Watanabe T., Fujiwara Y., Yamane T., Oshitani N., Hino M., Higuchi K., Arakawa T.

    ANNALS OF HEMATOLOGY   88 ( 8 )   789 - 793   2009.08( ISSN:0939-5555

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    DOI: 10.1007/s00277-008-0667-5

  • Lansoprazole, a Proton Pump Inhibitor, Suppresses Production of Tumor Necrosis Factor-alpha and Interleukin-1 beta Induced by Lipopolysaccharide and Helicobacter Pylori Bacterial Components in Human Monocytic Cells via Inhibition of Activation of Nuclear Reviewed

    Tanigawa Tetsuya, Watanabe Toshio, Higuchi Kazuhide, Machida Hirohisa, Okazaki Hirotoshi, Yamagami Hirokazu, Watanabe Kenji, Tominaga Kazunari, Fujiwara Yasuhiro, Oshitani Nobuhide, Arakawa Tetsuo

    JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION   45 ( 1 )   86 - 92   2009.07( ISSN:0912-0009

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  • Development of Pouchitis With Combination Therapy With Peg-Interferon alpha-2b and Ribavirin for Chronic Hepatitis C in a Patient With Ulcerative Colitis Who Underwent Pouch Surgery Reviewed

    Morimoto Kenichi, Yamagami Hirokazu, Hosomi Shuhei, Ohira Mizuki, Suekane Takehisa, Kamata Noriko, Sogawa Mitsue, Watanabe Kenji, Tominaga Kazunari, Watanabe Toshio, Fujiwara Yasuhiro, Tamori Akihiro, Oshitani Nobuhide, Arakawa Tetsuo

    AMERICAN JOURNAL OF GASTROENTEROLOGY   104 ( 6 )   1609 - 1610   2009.06( ISSN:0002-9270

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    DOI: 10.1038/ajg.2009.120

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  • Prevalence of mid-gastrointestinal bleeding in patients with acute overt gastrointestinal bleeding: multi-center experience with 1,044 consecutive patients Reviewed

    Okazaki Hirotoshi, Fujiwara Yasuhiro, Sugimori Satoshi, Nagami Yasuaki, Kameda Natsuhiko, Machida Hirohisa, Yamagami Hirokazu, Tanigawa Tetsuya, Shiba Masatsugu, Watanabe Kenji, Tominaga Kazunari, Watanabe Toshio, Oshitani Nobuhide, Arakawa Tetsuo

    JOURNAL OF GASTROENTEROLOGY   44 ( 6 )   550 - 555   2009.06( ISSN:0944-1174

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    DOI: 10.1007/s00535-009-0039-5

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  • 15-HYDROXYPROSTAGLANDIN DEHYDROGENASE IS DOWN-REGULATED DURING GASTRIC ULCER HEALING Reviewed

    TANIGAWA Tetsuya, WATANABE Toshio, TATSUWAKI Hiroshi, OKAZAKI Hirotoshi, TOMINAGA Kazunari, FUJIWARA Yasuhiro, OSHITANI Nobuhide, ARAKAWA Tetsuo

    36 ( 1 )   87 - 90   2009.05( ISSN:09163301

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  • ASSOCIATION BETWEEN GASTROESOPHAGEAL REFLUX DISEASE AND BRONCHIAL ASTHMA Reviewed

    FUJIWARA Yasuhiro, SUGAWA Takashi, TANIGAWA Tetsuya, WATANABE Toshio, TOMINAGA Kazunari, ARAKAWA Tetsuo

    36 ( 1 )   13 - 16   2009.05( ISSN:09163301

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  • Long-term use of nonsteroidal anti-inflammatory drugs normalizes the kinetics of gastric epithelial cells in patients with Helicobacter pylori infection via attenuation of gastric mucosal inflammation Reviewed

    TANIGAWA TETSUYA, WATANABE TOSHIO, HIGUCHI KAZUHIDE, TOMINAGA KAZUNARI, FUJIWARA YASUHIRO, OSHITANI NOBUHIDE, TARNAWSKI ANDRZEJ S., ARAKAWA TETSUO

    Journal of gastroenterology   44 ( 19 )   8 - 17   2009.05( ISSN:09441174

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  • Anti-inflammatory effects of IL-17A on Helicobacter pylori-induced gastritis Reviewed

    Otani Koji, Watanabe Toshio, Tanigawa Tetsuya, Okazaki Hirotoshi, Yarnagami Hirokazu, Watanabe Kenji, Tominaga Kazunari, Fujiwara Yasuhiro, Oshitani Nobuhide, Arakawa Tetsuo

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   382 ( 2 )   252 - 258   2009.05( ISSN:0006-291X

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    DOI: 10.1016/j.bbrc.2009.02.107

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  • Long-term use of nonsteroidal anti-inflammatory drugs normalizes the kinetics of gastric epithelial cells in patients with Helicobacter pylori infection via attenuation of gastric mucosal inflammation Reviewed

    Tanigawa Tetsuya, Watanabe Toshio, Higuchi Kazuhide, Tominaga Kazunari, Fujiwara Yasuhiro, Oshitani Nobuhide, Tarnawski Andrzej S., Arakawa Tetsuo

    JOURNAL OF GASTROENTEROLOGY   44   8 - 17   2009.01( ISSN:0944-1174

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    DOI: 10.1007/s00535-008-2287-1

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  • Association of Brain-gut Axis and the Autonomic Nervous System with the Pathogenesis and its Therapy of Functional Dyspepsia(Symposium/Brain-gut Interaction in the Pathophysiology of Functional Dyspepsia) Reviewed

    Tominaga Kazunari, Ochi Masahiro, Tanigawa Tetsuya, Watanabe Toshio, Fujiwara Yasuhiro, Oshitani Nobuhide, Arakawa Tetsuo

    Japanese Society of Psychosomatic Medicine, Japanese Journal of Psychosomatic Medicine   49 ( 7 )   783 - 790   2009( ISSN:03850307

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    Aim: As the pathogenesis of functional dyspepsia (FD) considering brain-gut axis, it is thought that daily stressors affect the autonomic nervous system (ANS), gastrointestinal motility, and various chemical mediators thereafter causing abdominal symptoms. We examined the effects of external stresses on gastric emptying in rats and the association of ANS with FD patients. Methods: 1. We examined various parameters: body weight, relative organ weight, catecholamine levels, and gastric emptying in 8-weeks old rats after water immersion stress restraint for 5 days. 2. We analyzed the 24hrs heart rate variability for FD patients after obtaining the questionnaire of daily stressors: component of high frequency (HF: 0.15-0.40Hz) for parasympathetic function and ratio of component of low frequency (LF: 0.04-0.15Hz) to HF component for sympathetic function. We examined 1) 24hrs balance, 2) changes after meal and cold or mental mathematical stressors, 3) effects of tofisopam, a psychovegetative regulator. Results: Stress significantly decreased body weight and relative weight of thymus, and increased relative weight of adrenal glands. Stress increased serum ACTH, corticosterone, adrenalin, and noradrenalin levels. Gastric emptying was decreased in the early phase of the stress restraint and increased in the late phase. Plasma total and inactive ghrelin levels were increased at 24hrs stress restraint and thereafter gradually decreased. Active ghrelin level began to increase at that time. Basal levels of parasympathetic tone were lower and the levels of sympathetic tone were higher in FD patients compared to those of controls. Parasympathetic tone levels of all controls during 30min after meal were higher than their basal condition. But those levels were increased in about half of FD patients. Sympathetic tone levels from 90 to 120 minutes after meal were increased in almost controls but in half of FD patients. Treatment with tofisopam ameliorated the basal imbalance to the normal balanced levels of ANS followed by improving dyspeptic symptoms of FD patients. Conclusions: Fragility of ANS and external stress may be associated with the gastric emptying and abdominal symptoms in FD patients. Treatment with tofisopam, a psychovegetative regulator, may be effective for FD patients.

    DOI: 10.15064/jjpm.49.7_783

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  • Exogenous administration of mesenchymal stem cells ameliorates dextran sulfate sodium-induced colitis via anti-inflammatory action in damaged tissue in rats Reviewed

    Tanaka Fumio, Tominaga Kazunari, Ochi Masahiro, Tanigawa Tetsuya, Watanabe Toshio, Fujiwara Yasuhiro, Ohta Kensuke, Oshitani Nobuhide, Higuchi Kazuhide, Arakawa Tetsuo

    LIFE SCIENCES   83 ( 23-24 )   771 - 779   2008.12( ISSN:0024-3205

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    DOI: 10.1016/j.lfs.2008.09.016

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  • Small Bowel Injury by Low-Dose Enteric-Coated Aspirin and Treatment With Misoprostol: A Pilot Study Reviewed

    Watanabe Toshio, Sugimori Satoshi, Kameda Natsuhiko, Machida Hirohisa, Okazaki Hirotoshi, Tanigawa Tetsuya, Watanabe Kenji, Tominaga Kazunari, Fujiwara Yasuhiro, Oshitani Nobuhide, Higuchi Kazuhide, Arakawa Tetsuo

    CLINICAL GASTROENTEROLOGY AND HEPATOLOGY   6 ( 11 )   1279 - 1282   2008.11( ISSN:1542-3565

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    DOI: 10.1016/j.cgh.2008.06.021

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  • Usefulness of Double-Balloon Endoscopy in the Diagnosis of Malignant Small-Bowel Tumors Reviewed

    Yamagami Hirokazu, Oshitani Nobuhide, Hosomi Shuhei, Suekane Takehisa, Kamata Noriko, Sogawa Mitsue, Okazaki Hirotoshi, Watanabe Kenji, Tominaga Kazunari, Watanabe Toshio, Fujiwara Yasuhiro, Arakawa Tetsuo

    CLINICAL GASTROENTEROLOGY AND HEPATOLOGY   6 ( 11 )   1202 - 1205   2008.11( ISSN:1542-3565

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    DOI: 10.1016/j.cgh.2008.05.014

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  • Perfectionism underlying psychological background correlated with the symptoms of functional dyspepsia Reviewed

    OCHI MASAHIRO, TOMINAGA KAZUNARI, IKETANI TOSHIYA, KADOUCHI KAORI, TANIGAWA TETSUYA, SHIBA MASATSUGU, WATANABE TOSHIO, FUJIWARA YASUHIRO, OSHITANI NOBUHIDE, HIGUCHI KAZUHIDE, KIRIIKE NOBUO, ARAKAWA TETSUO

    Journal of gastroenterology   43 ( 9 )   699 - 704   2008.09( ISSN:09441174

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  • Phenotypical and functional study of ghrelin and its receptor in the pathogenesis of Crohn's disease Reviewed

    Hosomi Shuhei, Oshitani Nobuhide, Kamata Noriko, Sogawa Mitsue, Yamagami Hirokazu, Watanabe Kenji, Tominaga Kazunari, Watanabe Toshio, Fujiwara Yosuhiro, Maeda Kiyoshi, Hirakawa Kosei, Arakawa Tetsuo

    INFLAMMATORY BOWEL DISEASES   14 ( 9 )   1205 - 1213   2008.09( ISSN:1078-0998

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    DOI: 10.1002/ibd.20477

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  • Proliferation of immature plasma cells in pouchitis mucosa in patients with ulcerative colitis Reviewed

    Hirata Naoto, Oshitani Nobuhide, Kamata Noriko, Sogawa Mitsue, Yamagami Hirokazu, Watanabe Kenji, Watanabe Toshio, Tominaga Kazunari, Fujiwara Yasuhiro, Maeda Kiyoshi, Hirakawa Kosei, Arakawa Tetsuo

    INFLAMMATORY BOWEL DISEASES   14 ( 8 )   1084 - 1090   2008.08( ISSN:1078-0998

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    DOI: 10.1002/ibd.20447

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  • A prospective, single-blind trial comparing wireless capsule endoscopy and double-balloon enteroscopy in patients with obscure gastrointestinal bleeding Reviewed

    KAMEDA NATSUHIKO, HIGUCHI KAZUHIDE, SHIBA MASATSUGU, MACHIDA HIROHISA, OKAZAKI HIROTOSHI, YAMAGAMI HIROKAZU, TANIGAWA TETSUYA, WATANABE KENJI, WATANABE TOSHIO, TOMINAGA KAZUNARI, FUJIWARA YASUHIRO, OSHITANI NOBUHIDE, ARAKAWA TETSUO

    Journal of gastroenterology   43 ( 6 )   434 - 440   2008.06( ISSN:09441174

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  • A novel rat model to determine interaction between reflux oesophagitis and bronchial asthma Reviewed

    Sugawa T., Fujiwara Y., Yamagami H., Watanabe K., Tanigawa T., Shiba M., Watanabe T., Tominaga K., Oshitani N., Higuchi K., Arakawa T.

    GUT   57 ( 5 )   575 - 581   2008.05( ISSN:0017-5749

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    DOI: 10.1136/gut.2007.138461

  • Effect of chronic stress on gastric emptying and plasma ghrelin levels in rats Reviewed

    Ochi Masahiro, Tominaga Kazunari, Tanaka Fumio, Tanigawa Tetsuya, Shiba Masatsugu, Watanabe Toshio, Fujiwara Yasuhiro, Oshitani Nobuhide, Higuchi Kazuhide, Arakawa Tetsuo

    LIFE SCIENCES   82 ( 15-16 )   862 - 868   2008.04( ISSN:0024-3205

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    DOI: 10.1016/j.lfs.2008.01.020

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  • ACTIVATION OF TOLL-LIKE RECEPTOR 4/MYD88 SIGNALING PATHWAY BY GRAM NEGATIVE BACTERIA PLAYS AN IMPORTANT ROLE IN THE PATHOGENESIS OF NSAIDS-INDUCED SMALL INTESTINAL DAMAGE Reviewed

    WATANABE Toshio, TANIGAWA Tetsuya, SHIBA Masatsugu, TOMINAGA Kazunari, FUJIWARA Yasuhiro, OSHITANI Nobuhide, HIGUCHI Kazuhide, ARAKAWA Tetsuo

    35 ( 1 )   35 - 38   2008.03( ISSN:09163301

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  • ACTIVE GHRELIN, AUTONOMIC NERVOUS SYSTEM, AND NITRIC OXIDE INDUCED BY iNOS HAVE INFLUENCED FOR GASTRIC EMPTYING UNDER CONTINUOUS STRESS IN RATS Reviewed

    OCHI Masahiro, TOMINAGA Kazunari, TANIGAWA Tetsuya, SHIBA Masatsugu, WATANABE Toshio, FUJIWARA Yasuhiro, OSHITANI Nobuhide, HIGUCHI Kazuhide, ARAKAWA Tetsuo

    35 ( 1 )   13 - 16   2008.03( ISSN:09163301

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  • Concurrent assessment of reservoir and emptying of the stomach for dyspepsia patients. Reviewed

    Tominaga K, Higuchi K, Ochi M, Kadouchi K, Kawamura E, Tanigawa T, Shiba M, Watanabe T, Fujiwara Y, Oshitani N, Shiomi S, Arakawa T

    Hepato-gastroenterology   55 ( 82-83 )   744 - 9   2008.03( ISSN:0172-6390

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  • Enhanced expressions of endothelin-converting enzyme and endothelin receptors in human colonic tissues of Crohn's disease. Reviewed

    Suekane T, Ikura Y, Arimoto J, Nakagawa M, Kitabayashi C, Naruko T, Watanabe T, Fujiwara Y, Oshitani N, Maeda K, Tanzawa K, Hirakawa K, Arakawa T, Ueda M

    日本酸化ストレス学会 Journal of clinical biochemistry and nutrition   42 ( 2 )   126 - 32   2008.03( ISSN:0912-0009

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    Endothelin-1, a powerful vasoconstrictor, forms the endothelin system together with endothelin-converting enzyme and endothelin type A and type B receptors. These endothelin system components are considered to participate in inflammatory and wound healing responses. Previous reports have suggested a role for the endothelin-1 in the pathology of Crohn&rsquo;s disease. In the present study, we immunohistochemically investigated the expressions of the endothelin system components in affected human intestinal tissues of Crohn&rsquo;s disease. Eighteen surgical specimens of colonic tissue obtained from patients with Crohn&rsquo;s disease and 12 normal colonic tissues as controls were examined. Frozen tissue sections cut from the samples were subjected to the immunohistochemical single and double staining. The endothelin system components were expressed mainly in the muscular layers and blood vessels. In diseased colonic tissues, inflammatory infiltration and fibrotic tissue reactions with marked smooth muscle cell proliferation were frequently seen, and were closely associated with increased expressions of the endothelin system components. These results strongly suggest that endothelin-converting enzyme and endothelin type A and type B receptors collectively play a role in the inflammatory and fibrogenic processes of Crohn&rsquo;s disease. Especially, submucosal smooth muscle proliferation, a histological hallmark of strictures, may be attributable to the upregulated endothelin system.<br>

    DOI: 10.3164/jcbn.2008018

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  • Non-steroidal anti-inflammatory drug-induced small intestinal damage is Toll-like receptor 4 dependent Reviewed

    Watanabe T., Higuchi K., Kobata A., Nishio H., Tanigawa T., Shiba M., Tominaga K., Fujiwara Y., Oshitani N., Asahara T., Nomoto K., Takeuchi K., Arakawa T.

    GUT   57 ( 2 )   181 - 187   2008.02( ISSN:0017-5749

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    DOI: 10.1136/gut.2007.125963

  • Management of gastric fundal varices without gastro-renal shunt in 15 patients. Reviewed

    Kameda N, Higuchi K, Shiba M, Kadouchi K, Machida H, Okazaki H, Tanigawa T, Watanabe T, Tominaga K, Fujiwara Y, Nakamura K, Arakawa T

    World journal of gastroenterology   14 ( 3 )   448 - 53   2008.01( ISSN:1007-9327

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  • Interleukin-10 gene transfer to peritoneal mesothelial cells suppresses peritoneal dissemination of gastric cancer cells due to a persistently high concentration in the peritoneal cavity Reviewed

    Tanaka F., Tominaga K., Shiota M., Ochi M., Kuwamura H., Tanigawa T., Watanabe T., Fujiwara Y., Oshitani N., Higuchi K., Iwao H., Arakawa T.

    CANCER GENE THERAPY   15 ( 1 )   51 - 59   2008.01( ISSN:0929-1903

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    DOI: 10.1038/sj.cgt.7701104

  • Small bowel injury in patients with rheumatoid arthritis by capsule endoscopy - Effect of nonsteroidal anti-inflammatory drugs Reviewed

    Xu Y., Watanabe T., Sugimori S., Tabuchi M., Kameda N., Kadouchi K., Machida H., Okazaki H., Sogawa M., Yamagami H., Tanigawa T., Shiba M., Watanabe K., Tominaga K., Fujiwara Y., Oshitani N., Koike T., Higuchi K., Arakawa T.

    DIGESTION   77   62 - 62   2008( ISSN:0012-2823

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  • SIV-2 脳腸相関性と自律神経系からみたFD病態とその治療(シンポジウムIV 機能性胃腸症(Functional Dyspepsia)の病態を巡る脳腸相関,情動ストレス研究の進歩と心身医学,第49回日本心身医学会総会ならびに学術講演会) Reviewed

    富永 和作, 越智 正博, 谷川 徹也, 渡辺 俊雄, 藤原 靖弘, 押谷 伸英, 荒川 哲男

    一般社団法人 日本心身医学会 心身医学   48 ( 6 )   2008

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    DOI: 10.15064/jjpm.48.6_459_2

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  • Indomethacin may injure the small intestine through a toll-like receptor 4/MyD88-dependent pathway Reviewed

    Watanabe T., Fujiwara Y., Kobata A., Nishio H., Tanigawa T., Shiba M., Tominaga K., Oshitani N., Asahara T., Nomoto K., Takeuchi K., Higuchi K., Arakawa T.

    DIGESTION   77   63 - 64   2008( ISSN:0012-2823

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  • Evaluation of Small Bowel Injury in Patients with Rheumatoid Arthritis by Capsule Endoscopy: Effects of Anti-Rheumatoid Arthritis Drugs Reviewed

    Sugimori Satoshi, Watanabe Toshio, Tabuchi Masahiko, Kameda Natsuhiko, Machida Hirohisa, Okazaki Hirotoshi, Tanigawa Tetsuya, Yamagami Hirokazu, Shiba Masatsugu, Watanabe Kenji, Tominaga Kazunari, Fujiwara Yasuhiro, Oshitani Nobuhide, Koike Tatsuya, Higuchi Kazuhide, Arakawa Tetsuo

    DIGESTION   78 ( 4 )   208 - 213   2008( ISSN:0012-2823

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    DOI: 10.1159/000190403

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  • A prospective, single-blind trial comparing wireless capsule endoscopy and double-balloon enteroscopy in patients with obscure gastrointestinal bleeding Reviewed

    Kameda Natsuhiko, Higuchi Kazuhide, Shiba Masatsugu, Machida Hirohisa, Okazaki Hirotoshi, Yamagami Hirokazu, Tanigawa Tftsuya, Watanabe Kenji, Watanabe Toshio, Tominaga Kazunari, Fujiwara Yasuhiro, Oshitani Nobuhide, Arakawa Tetsuo

    JOURNAL OF GASTROENTEROLOGY   43 ( 6 )   434 - 440   2008( ISSN:0944-1174

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    DOI: 10.1007/s00535-008-2182-9

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  • Concurrent assessment of reservoir and emptying of the stomach for dyspepsia patients Reviewed

    Tominaga Kazunari, Higuchi Kazuhide, Ochi Masahiro, Kadouchi Kaori, Kawamura Etsushi, Tanigawa Tetsuya, Shiba Masatsugu, Watanabe Toshio, Fujiwara Yasuhiro, Shiomi Nobuhide Oshitani Susumu, Arakawa Tetsuo

    HEPATO-GASTROENTEROLOGY   55 ( 82-83 )   744 - 749   2008( ISSN:0172-6390

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  • Plummer-Vinson syndrome successfully treated by endoscopic dilatation. Reviewed

    Enomoto M, Kohmoto M, Arafa UA, Shiba M, Watanabe T, Tominaga K, Fujiwara Y, Saeki Y, Higuchi K, Nishiguchi S, Shiomi S, Osugi H, Kinoshita H, Arakawa T

    Journal of gastroenterology and hepatology   22 ( 12 )   2348 - 51   2007.12( ISSN:0815-9319

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    DOI: 10.1111/j.1440-1746.2006.03430.x

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  • [Side effects of gastric muco-protective agents]. Reviewed

    Sugimori S, Watanabe T, Arakawa T

    Nihon rinsho. Japanese journal of clinical medicine   65 Suppl 8   193 - 7   2007.10( ISSN:0047-1852

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  • [Clinical features of NSAID-induced small intestinal damage]. Reviewed

    Sugimori S, Watanabe T, Shiba M, Higuchi K, Arakawa T

    Nihon rinsho. Japanese journal of clinical medicine   65 ( 10 )   1862 - 5   2007.10( ISSN:0047-1852

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  • Synergistic antitumor effect of combined 5-fluorouracil (5-FU) with 5-chloro-2,4-dihydroxypyridine on 5-FU-resistant gastric cancer cells: possible role of a dihydropyrimidine dehydrogenase-independent mechanism Reviewed

    Sasaki Eiji, Tominaga Kazunari, Kuwamura Hikaru, Watanabe Toshio, Fujiwara Yasuhiro, Oshitani Nobuhide, Higuchi Kazuhide, Arakawa Tetsuo

    JOURNAL OF GASTROENTEROLOGY   42 ( 10 )   816 - 822   2007.10( ISSN:0944-1174

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    DOI: 10.1007/s00535-007-2101-5

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  • Anti-inflammatory effects of pravastatin on Helicobacter pylori-induced gastritis in mice Reviewed

    Yamato Masanori, Watanabe Toshio, Higuchi Kazuhide, Taira Koichi, Tanigawa Tetsuya, Shiba Masatsugu, Tominaga Kazunari, Fujiwara Yasuhiro, Oshitani Nobuhide, Takeuchi Koji, Arakawa Tetsuo

    DIGESTIVE DISEASES AND SCIENCES   52 ( 10 )   2833 - 2839   2007.10( ISSN:0163-2116

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    DOI: 10.1007/s10620-006-9638-7

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  • [The role of mucoprotective drugs in a treatment and prevention for NSAID-induced gastric ulcer]. Reviewed

    Okuyama M, Tominaga K, Tanigawa T, Shiba M, Watanabe T, Fujiwara Y, Oshitani N, Higuchi K, Arakawa T

    Nihon rinsho. Japanese journal of clinical medicine   65 ( 10 )   1850 - 5   2007.10( ISSN:0047-1852

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  • Primary duodenal lymphoma: Successful rituximab treatment and evaluation by FDG-PET Reviewed

    Tanaka Fumio, Tominaga Kazunari, Ochi Masahiro, Yamada Takao, Sasaki Eiji, Shiba Masatsugu, Watanabe Toshio, Fujiwara Yasuhiro, Uchida Toshiyuki, Oshitani Nobuhide, Higuchi Kazuhide, Arakawa Tetsuo

    HEPATO-GASTROENTEROLOGY   54 ( 78 )   1658 - 1661   2007.09( ISSN:0172-6390

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  • LAFUTIDINE PROMOTES HEALING OF GASTRIC ULCER IN STREPTOZOTOCIN-INDUCED DIABETIC RATS Reviewed

    TANIGAWA Tetsuya, WATANABE Toshio, OCHI Masahiro, TANAKA Fumio, SUGAWA Takashi, HAYAKAWA Tsuyoshi, SASAKI Eiji, SHIBA Masatsugu, TOMINAGA Kazunari, FUJIWARA Yasuhiro, OSHITANI Nobuhide, HIGUCHI Kazuhide, ARAKAWA Tetsuo

    34 ( 1 )   38 - 41   2007.05( ISSN:09163301

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  • GASTROESOPHAGEAL REFLUX DISEASE AND SLEEP DISTURBANCE IN JAPAN Reviewed

    FUJIWARA Yasuhiro, HIGUCHI Kazuhide, TANIGAWA Tetsuya, WATANABE Toshio, TOMINAGA Kazunari, ARAKAWA Tetsuo

    34 ( 1 )   7 - 10   2007.05( ISSN:09163301

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  • [Prevalence, diagnosis and treatment of extraesophageal manifestations of GERD]. Reviewed

    Sugawa T, Fujiwara Y, Okuyama M, Tanigawa T, Shiba M, Tominaga K, Watanabe T, Oshitani N, Higuchi K, Arakawa T

    Nihon rinsho. Japanese journal of clinical medicine   65 ( 5 )   946 - 50   2007.05( ISSN:0047-1852

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  • Four-year follow-up of the first case of gastroesophageal reflux disease treated with endoluminal gastroplication in Japan Reviewed

    HIGUCHI Kazuhide, SHIBA Masatsugu, OKAZAKI Hirotoshi, TABUCHI Masahiko, KAMEDA Natsuhiko, KADOUCHI Kaori, TOMINAGA Kazunari, WATANABE Toshio, FUJIWARA Yasuhiro, OSHITANI Nobuhide, ARAKAWA Tetsuo

    Journal of gastroenterology   42 ( 4 )   325 - 326   2007.04( ISSN:09441174

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  • Growth inhibition of colon cancer cells by transfection of dominant-negative apoptosis signal-regulating kinase-1 Reviewed

    Kuwamura Hikaru, Tominaga Kazunari, Shiota Masayuki, Ashida Reiko, Nakao Takafumi, Sasaki Eiji, Watanabe Toshio, Fujiwara Yasuhiro, Oshitani Nobuhide, Higuchi Kazuhide, Ichijo Hidenori, Arakawa Tetsuo, Iwao Hiroshi

    ONCOLOGY REPORTS   17 ( 4 )   781 - 786   2007.04( ISSN:1021-335X

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  • A case of mucosa-associated lymphoid tissue lymphoma forming multiple lymphomatous polyposis in the small intestine Reviewed

    Hirata Naoto, Tominaga Kazunari, Ohta Kensuke, Kadouchi Kaori, Okazaki Hirotoshi, Tanigawa Tetsuya, Shiba Masatsugu, Watanabe Toshio, Fujiwara Yasuhiro, Nakamura Shiro, Oshitani Nobuhide, Higuchi Kazuhide, Arakawa Tetsuo

    WORLD JOURNAL OF GASTROENTEROLOGY   13 ( 9 )   1453 - 1457   2007.03( ISSN:1007-9327

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  • Feasibility, safety, and efficacy of the Stretta procedure in Japanese patients with gastroesophageal reflux disease: first report from Asia Reviewed

    Higuchi Kazuhide, Fujiwara Yasuhiro, Okazaki Hirotoshi, Tabuchi Masahiko, Kameda Natsuhiko, Kadouchi Kaori, Machida Hirohisa, Tanigawa Tetsuya, Shiba Masatsugu, Watanabe Toshio, Tominaga Kazunari, Oshitani Nobuhide, Arakawa Tetsuo

    JOURNAL OF GASTROENTEROLOGY   42 ( 3 )   205 - 210   2007.03( ISSN:0944-1174

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    DOI: 10.1007/s00535-006-1944-5

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  • What are the risk factors for aggravation of esophageal varices in patients with hepatocellular carcinoma? Reviewed

    Kadouchi Kaori, Higuchi Kazuhide, Shiba Masatsugu, Okazaki Hirotoshi, Yamamori Kazuki, Sasaki Eiji, Tominaga Kazunari, Watanabe Toshio, Fujiwara Yasuhiro, Oshitani Nobuhide, Arakawa Tetsuo

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   22 ( 2 )   240 - 246   2007.02( ISSN:0815-9319

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    DOI: 10.1111/j.1440-1746.2006.04418.x

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  • Laparoscopic observation of 2 cases of nodular regenerative hyperplasia of the liver. Reviewed

    Fujii H, Sakaguchi H, Enomoto M, Yamamori K, Inagawa M, Watanabe T, Kawada N, Seki S, Arakawa T

    Gastrointestinal endoscopy   65 ( 1 )   171 - 3   2007.01( ISSN:0016-5107

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    DOI: 10.1016/j.gie.2006.08.001

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  • Roles of ZO-1 and epidermal growth factor in esophageal epithelial defense against acid. Reviewed

    Okuyama M, Fujiwara Y, Tanigawa T, Watanabe K, Shiba M, Tominaga K, Watanabe T, Oshitani N, Higuchi K, Arakawa T

    Digestion   75 ( 2-3 )   135 - 41   2007( ISSN:0012-2823

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    DOI: 10.1159/000106454

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  • ENDOLUMINAL THERAPIES FOR REFLUX ESOPHAGITIS Reviewed

    HIGUCHI Kazuhide, OKAZAKI Hirotoshi, TABUCHI Masahiko, SHIBA Masatsugu, WATANABE Toshio, TOMINAGA Kazunari, FUJIWARA Yasuhiro, ARAKAWA Tetsuo

    Japan Gastroenterological Endoscopy Society, GASTROENTEROLOGICAL ENDOSCOPY   48 ( 12 )   2763 - 2771   2006.12( ISSN:03871207

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    Gastroesophageal reflux disease is a common medical condition that typically requires lifelong medical therapy or surgery for the management of patients with frequent symptoms. The standard of care for patients with GERD is to begin treatment with acid suppressants. Currently, three endoluminal therapies for GERD are approved for use in the western countries. Clinical trials have examined either an endoscopic suturing, injection intervention, or thermal approach in the area of the lower esophageal sphincter. They are found to be useful for the treatment of GERD. However, the reported follow-up periods are short. The risk/benefit profile must be carefully evaluated for each of these interventions for a long-term.

    DOI: 10.11280/gee1973b.48.2763

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  • Interactions between the grading of gastric atrophy associated with Helicobacter pylori infection and the severity of clinical symptoms and delay in gastric emptying in patients with functional dyspepsia Reviewed

    Kadouchi K., Tominaga K., Ochi M., Kawamura E., Sasaki E., Shiba M., Watanabe T., Fujiwara Y., Oshitani N., Higuchi K., Shiomi S., Arakawa T.

    ALIMENTARY PHARMACOLOGY & THERAPEUTICS   24   49 - 57   2006.12( ISSN:0269-2813

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    DOI: 10.1111/j.1365-2036.2006.00025.x

  • ANTI-INFLAMMATORY FUNCTIONS INDUCED BY BONE MARROW-DERIVED MESENCHYMAL STEM CELLS FOR DEXTRAN SULFATE SODIUM-INDUCED COLITIS IN RATS Reviewed

    TANAKA Fumio, TOMINAGA Kazunari, OCHI Masahiro, TANIGAWA Tetsuya, SASAKI Eiji, WATANABE Toshio, FUJIWARA Yasuhiro, OSHITANI Nobuhide, HIGUCHI Kazuhide, ARAKAWA Tetsuo

    33 ( 2 )   135 - 138   2006.09( ISSN:09163301

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  • Successful treatment of giant rectal varices by modified percutaneous transhepatic obliteration with sclerosant: Report of a case Reviewed

    Okazaki Hirotoshi, Higuchi Kazuhide, Shiba Masatsugu, Nakamura Shirou, Wada Tomoko, Yamamori Kazuki, Machida Ai, Kadouchi Kaori, Tamori Akihiro, Tominaga Kazunari, Watanabe Toshio, Fujiwara Yasuhiro, Nakamura Kenji, Arakawa Tetsuo

    WORLD JOURNAL OF GASTROENTEROLOGY   12 ( 33 )   5408 - 5411   2006.09( ISSN:1007-9327

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  • Production of reactive oxygen species in peripheral blood is increased in individuals with Helicobacter pylori infection and decreased after its eradication Reviewed

    Mashimo Masayuki, Nishikawa Manabu, Higuchi Kazuhide, Hirose Masaki, Wei Qian, Haque Anwarul, Sasaki Eiji, Shiba Masatsugu, Tominaga Kazunari, Watanabe Toshio, Fujiwara Yasuhiro, Arakawa Tetsuo, Inoue Masayasu

    HELICOBACTER   11 ( 4 )   266 - 271   2006.08( ISSN:1083-4389

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  • Rumination syndrome in an adult with normal intelligence Reviewed

    SUGAWA Takashi, FUJIWARA Yasuhiro, OKUYAMA Masatsugu, HAYAKAWA Tsuyoshi, YAMAGAMI Hirokazu, WATANABE Kenji, SASAKI Eiji, SHIBA Masatsugu, WATANABE Toshio, TOMINAGA Kazunari, OSHITANI Nobuhide, HIGUCHI Kazuhide, ARAKAWA Tetsuo

    The Japanese Society of Gastroenterology, Nippon Shokakibyo Gakkai Zasshi   103 ( 6 )   631 - 635   2006.06( ISSN:04466586

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    A 32-year-old woman visited our department because of repeated regurgitation of foodC and was diagnosed with rumination syndrome based on possession of symptoms typical for it. Although rumination syndrome is classified as a functional esophageal disorder according to the Rome II criteriaC it is not well known in JapanC and there have been no previous reports of it in an adult with normal intelligence. Since patients with rumination syndrome are often misdiagnosed and receive unnecessary treatmentC awareness of it by physicians is important.<br>

    DOI: 10.11405/nisshoshi.103.631

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  • [Rumination syndrome in an adult with normal intelligence]. Reviewed

    Sugawa T, Fujiwara Y, Okuyama M, Hayakawa T, Yamagami H, Watanabe K, Sasaki E, Shiba M, Watanabe T, Tominaga K, Oshitani N, Higuchi K, Arakawa T

    Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology   103 ( 6 )   631 - 5   2006.06( ISSN:0446-6586

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  • PHARMACOLOGICAL THERAPY FOR GASTROINTESTINAL HEMORRHAGE Reviewed

    HIGUCHI Kazuhide, WATANABE Toshio, TOMINGA Kazunari, FUJIWARA Yasuhiro, ARAKAWA Tetsuo

    33 ( 1 )   37 - 40   2006.05( ISSN:09163301

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  • LEPTIN PROMOTES ANGIOGENESIS VIA UPREGULATION OF PROANGIOGENIC GROWTH FACTORS DURING GASTRIC ULCER HEALING Reviewed

    TANIGAWA Tetsuya, WATANABE Toshio, SASAKI Eiji, TOMINAGA Kazunari, FUJIWARA Yasuhiro, OSHITANI Nobuhide, HIGUCHI Kazuhide, ARAKAWA Tetsuo

    33 ( 1 )   30 - 33   2006.05( ISSN:09163301

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  • Roles of cyclooxygenase 2 and microsomal prostaglandin E synthase 1 in rat acid reflux oesophagitis Reviewed

    Hayakawa T, Fujiwara Y, Hamaguchi M, Sugawa T, Okuyama M, Sasaki E, Watanabe T, Tominaga K, Oshitani N, Higuchi K, Arakawa T

    GUT   55 ( 4 )   450 - 456   2006.04( ISSN:0017-5749

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    DOI: 10.1136/gut.2005.081943

  • Roles of epidermal growth factor and Na+/H+ exchanger-1 in esophageal epithelial defense against acid-induced injury Reviewed

    Fujiwara Y, Higuchi K, Takashima T, Hamaguchi M, Hayakawa T, Tominaga K, Watanabe T, Oshitani N, Shimada Y, Arakawa T

    AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY   290 ( 4 )   G665 - G673   2006.04( ISSN:0193-1857

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    DOI: 10.1152/ajpgi.00238.2005

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  • Regression of primary low-grade mucosa-associated lymphoid tissue lymphoma of duodenum after long-term treatment with clarithromycin Reviewed

    Ochi M, Tominaga K, Okazaki H, Yamamori K, Wada T, Shiba M, Sasaki E, Watanabe T, Fujiwara Y, Oshitani N, Higuchi K, Arakawa T

    SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY   41 ( 3 )   365 - 369   2006.03( ISSN:0036-5521

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  • Prophylactic effect of Lactobacillus casei strain Shirota on NSAID-induced small intestinal damage Reviewed

    Nishio H, Watanabe T, Higuchi K, Asahara T, Nomoto K, Kato S, Arakawa T, Takeuchi K

    JOURNAL OF PHARMACOLOGICAL SCIENCES   100   84P - 84P   2006( ISSN:1347-8613

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  • Risk factors for bleeding after endoscopic mucosal resection Reviewed

    Shiba Masatsugu, Higuchi Kazuhide, Kadouchi Kaori, Montani Ai, Yamamori Kazuki, Okazaki Hirotoshi, Taguchi Makiko, Wada Tomoko, Itani Atsushi, Watanabe Toshio, Tominaga Kazunari, Fujiwara Yoshihiro, Hayashi Tomoshige, Tsumura Kei, Arakawa Tetsuo

    WORLD JOURNAL OF GASTROENTEROLOGY   11 ( 46 )   7335 - 7339   2005.12( ISSN:1007-9327

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  • Association between dinner-to-bed time and gastro-esophageal reflux disease Reviewed

    Fujiwara Y, Machida A, Watanabe Y, Shiba M, Tominaga K, Watanabe T, Oshitani N, Higuchi K, Arakawa T

    AMERICAN JOURNAL OF GASTROENTEROLOGY   100 ( 12 )   2633 - 2636   2005.12( ISSN:0002-9270

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    DOI: 10.1111/j.1572-0241.2005.00354.x

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  • Association of psychological factors with the pathophysiology of functional dyspepsia Reviewed

    TOMINAGA Kazunari, HIGUCHI Kazuhide, IKETANI Toshiya, OCHI Masahiro, KADOUCHI Kaori, SASAKI Eiji, SHIBA Masatsugu, WATANABE Toshio, FUJIWARA Yasuhiro, OSHITANI Nobuhide, NAGATA Toshihiko, KIRIIKE Nobuo, ARAKAWA Tetsuo

    9 ( 4 )   200 - 204   2005.11( ISSN:13429558

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  • EFFECT OF LANSOPRAZOLE ON REGULATION OF CYTOKINE PRODUCTION IN HUMAN MONOCYTES Reviewed

    TAKASHIMA Takashi, FUJIWARA Yasuhiho, HAMAGUCHI Masaki, SASAKI Eiji, WATANABE Toshio, TOMINAGA Kazunari, HIGUCHI Kazuhide, ARAKAWA Tetsuo

    32 ( 2 )   188 - 190   2005.11( ISSN:09163301

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  • [Antibacterial activity of a Chinese herbal medicine, Gosyuyu (Wu-Chu-Yu), against Helicobacter pylori]. Reviewed

    Tominaga K, Higuchi K, Hamasaki N, Tanigawa T, Sasaki E, Watanabe T, Fujiwara Y, Oshitani N, Arakawa T, Ishii E, Tezuka Y, Nagaoka T, Kadota S

    Nihon rinsho. Japanese journal of clinical medicine   63 Suppl 11   592 - 9   2005.11( ISSN:0047-1852

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  • [Roles of cyclooxygenase-2 in gastric mucosal defense in Helicobacter pylori-infected gastric mucosa]. Reviewed

    Taira K, Watanabe T, Tanigawa T, Higuchi K, Arakawa T

    Nihon rinsho. Japanese journal of clinical medicine   63 Suppl 11   123 - 6   2005.11( ISSN:0047-1852

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  • [Quality of ulcer healing and rebamipide]. Reviewed

    Fujiwara Y, Higuchi K, Tominaga K, Watanabe T, Arakawa T

    Nihon rinsho. Japanese journal of clinical medicine   63 Suppl 11   397 - 400   2005.11( ISSN:0047-1852

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  • 15th anniversary of rebamipide: Looking ahead to the new mechanisms and new applications Reviewed

    Arakawa T, Higuchi K, Fujiwara Y, Watanabe T, Tominaga K, Sasaki E, Oshitani N, Yoshikawa T, Tarnawski AS

    DIGESTIVE DISEASES AND SCIENCES   50   S3 - S11   2005.10( ISSN:0163-2116

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    DOI: 10.1007/s10620-005-2800-9

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  • Rebamipide reduces delay in gastric ulcer healing in cyclooxygenase-2-deficient mice Reviewed

    Watanabe T, Higuchi K, Taira K, Sasaki E, Shiba M, Tominaga K, Fujiwara Y, Oshitani N, Arakawa T

    DIGESTIVE DISEASES AND SCIENCES   50   S63 - S69   2005.10( ISSN:0163-2116

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    DOI: 10.1007/s10620-005-2808-1

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  • Famotidine vs. omeprazole: a prospective randomized multicentre trial to determine efficacy in non-erosive gastro-oesophageal reflux disease Reviewed

    Fujiwara Y, Higuchi K, Nebiki H, Chono S, Uno H, Kitada K, Satoh H, Nakagawa K, Kobayashi K, Tominaga K, Watanabe T, Oshitani N, Arakawa T

    ALIMENTARY PHARMACOLOGY & THERAPEUTICS   21   10 - 18   2005.06( ISSN:0269-2813

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  • Relationship between peroxisome proliferator-activated receptor-gamma expression and differentiation of human esophageal squamous cell carcinoma Reviewed

    Takashima T, Fujiwara Y, Hamaguchi M, Sasaki E, Tominaga K, Watanabe T, Oshitani N, Higuchi K, Arakawa T

    ONCOLOGY REPORTS   13 ( 4 )   601 - 606   2005.04( ISSN:1021-335X

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  • Differences in clinical characteristics between patients with endoscopy-negative reflux disease and erosive esophagitis in Japan Reviewed

    Fujiwara Y, Higuchi K, Shiba M, Yamamori K, Watanabe Y, Sasaki E, Tominaga K, Watanabe T, Oshitani N, Arakawa T

    AMERICAN JOURNAL OF GASTROENTEROLOGY   100 ( 4 )   754 - 758   2005.04( ISSN:0002-9270

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    DOI: 10.1111/j.1572-0241.2005.40966.x

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  • Successful Treatment with Cyclophosphamide Pulse Therapy in a Case of Autoimmune Protein-losing Enteropaty Reviewed

    HOTTA Kiyoshi, FUJIWARA Yasuhiro, YAMAMORI Kazuki, ITANI Atushi, SASAKI Eiji, WATANABE Kenji, SHIBA Masatsugu, TOMINAGA Kazunari, WATANABE Toshio, NAKAMURA Shiro, OSHITANI Nobuhide, HIGUCHI Kazuhide, ARAKAWA Tetsuo

    47 ( 2 )   200 - 205   2005.02( ISSN:03871207

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    CiNii Article

  • Filamin A-bound PEBP2beta/CBFbeta is retained in the cytoplasm and prevented from functioning as a partner of the Runx1 transcription factor. Reviewed

    Yoshida N, Ogata T, Tanabe K, Li S, Nakazato M, Kohu K, Takafuta T, Shapiro S, Ohta Y, Satake M, Watanabe T

    Molecular and cellular biology   25 ( 3 )   1003 - 12   2005.02( ISSN:0270-7306

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    DOI: 10.1128/MCB.25.3.1003-1012.2005

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  • Prevalence of gastroesophageal reflux disease and gastroesophageal reflux disease symptoms in Japan. Reviewed

    Fujiwara Y, Higuchi K, Watanabe Y, Shiba M, Watanabe T, Tominaga K, Oshitani N, Matsumoto T, Nishikawa H, Arakawa T

    Journal of gastroenterology and hepatology   20 ( 1 )   26 - 9   2005.01( ISSN:0815-9319

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    DOI: 10.1111/j.1440-1746.2004.03521.x

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  • AP-1 and colorectal cancer. Reviewed

    Ashida R, Tominaga K, Sasaki E, Watanabe T, Fujiwara Y, Oshitani N, Higuchi K, Mitsuyama S, Iwao H, Arakawa T

    Inflammopharmacology   13 ( 1-3 )   113 - 25   2005( ISSN:0925-4692

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    DOI: 10.1163/156856005774423935

    PubMed

  • Lansoprazole binding to the neutrophils in dextran sulfate sodium-induced rat colitis. Reviewed

    Nakamura M, Asada M, Atsuda K, Matsui H, Watanabe T, Higuchi K, Arakawa T, Hibi N, Tsuchimoto K

    Inflammopharmacology   13 ( 1-3 )   303 - 15   2005( ISSN:0925-4692

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    DOI: 10.1163/156856005774423980

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  • Functional oesophageal epithelial defense against acid. Reviewed

    Fujiwara Y, Higuchi K, Tominaga K, Watanabe T, Oshitani N, Arakawa T

    Inflammopharmacology   13 ( 1-3 )   1 - 13   2005( ISSN:0925-4692

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    DOI: 10.1163/156856005774423953

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  • SUCCESSFUL TREATMENT WITH CYCLOPHOSPHAMIDE PULSE THERAPY IN A CASE OF AUTOIMMUNE PROTEIN-LOSING ENTEROPATY Reviewed

    HOTTA Kiyoshi, FUJIWARA Yasuhiro, YAMAMORI Kazuki, ITANI Atushi, SASAKI Fiji, WATANABE Kenji, SHIBA Masatsugu, TOMINAGA Kazunari, WATANABE Toshio, NAKAMURA Shiro, OSHITANI Nobuhide, HIGUCHI Kazuhide, ARAKAWA Tetsuo

    Japan Gastroenterological Endoscopy Society, GASTROENTEROLOGICAL ENDOSCOPY   47 ( 2 )   200 - 205   2005

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    A 41-year-old man was admitted to our hospital because of face and leg edema. Blood examination revealed hypoalbuminemia and positive reaction for anti-nuclear antibodies and anti-Sm antibodies. Abdominal scintigram using 99mTc-labeled human albumin revealed abnormal radioactivity in the ascending and transverse colon, suggesting albumin losing from terminal ileum or ascending colon. Colonoscopy revealed slight reddish mucosa and histology of biopsy specimen showed mild edema and inflammatory cell infiltration. Immunofluorescense study revealed deposition of C3 in the endothelium of colonic mucosa. Diagnosis of autoimmune protein-losing enteropathy was made. Steroid therapy was not effective and cyclophosphamide pulse therapy resulted in a significant recovery of serum albumin level and improvement of clinical symptoms.

    DOI: 10.11280/gee1973b.47.200

    CiNii Article

  • Biomarkers in patients with gastric inflammation: A systematic review Reviewed

    Naito Y, Ito M, Watanabe T, Suzuki H

    DIGESTION   72 ( 2-3 )   164 - 180   2005( ISSN:0012-2823

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    DOI: 10.1159/000088396

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  • Effects of ranitidine on quality of gastric ulcer healing compared with famotidine: A randomized, controlled, multicenter trial Reviewed

    Higuchi K, Watanabe T, Tominaga K, Shiba M, Nakagawa K, Uno H, Kitada K, Satoh H, Chono S, Uchida T, Fujiwara Y, Arakawa T

    INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY RESEARCH   25 ( 4 )   187 - 194   2005( ISSN:0251-1649

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  • Monocyte chemotactic protein-1 regulates leukocyte recruitment during gastric ulcer recurrence induced by tumor necrosis factor-alpha Reviewed

    Watanabe T, Higuchi K, Hamaguchi M, Shiba M, Tominaga K, Fujiwara Y, Matsumoto T, Arakawa T

    AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY   287 ( 4 )   G919 - G928   2004.10( ISSN:0193-1857

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    DOI: 10.1152/ajpgi.00372.2003

  • Correlation of MAP kinases with COX-2 induction differs between MKN45 and HT29 cells Reviewed

    Tominaga K, Higuchi K, Sasaki E, Suto R, Watanabe T, Fujiwara Y, Oshitani N, Matsumoto T, Kim S, Iwao H, Arakawa T

    ALIMENTARY PHARMACOLOGY & THERAPEUTICS   20   143 - 150   2004.07( ISSN:0269-2813

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  • Prevalence of symptomatic gastro-oesophageal reflux disease in Japanese patients with peptic ulcer disease after eradication of Helicobacter pylori infection Reviewed

    Yamamori K, Fujiwara Y, Shiba M, Watanabe T, Tominaga K, Oshitani N, Matsumoto T, Higuchi K, Arakawa T

    ALIMENTARY PHARMACOLOGY & THERAPEUTICS   20   107 - 111   2004.07( ISSN:0269-2813

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  • Increased expression of transforming growth factor-alpha and epidermal growth factor receptors in rat chronic reflux esophagitis Reviewed

    Fujiwara Y, Higuchi K, Hamaguchi M, Takashima T, Watanabe T, Tominaga K, Oshitani N, Matsumoto T, Arakawa T

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   19 ( 5 )   521 - 527   2004.05( ISSN:0815-9319

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  • Has Helicobacter pylori eradication for peptic ulcer been overrated? Reviewed

    Arakawa T, Higuchi K, Fujiwara Y, Tominaga K, Watanabe T, Shiba M, Oshitani N, Matsumoto T

    INTERNAL MEDICINE   43 ( 3 )   179 - 183   2004.03( ISSN:0918-2918

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  • Anti-inflammatory effect of two isoforms of COX in H-pylori-induced gastritis in mice: possible involvement of PGE(2) Reviewed

    Tanigawa T, Watanabe T, Hamaguchi M, Sasaki E, Tominaga K, Fujiwara Y, Oshitani N, Matsumoto T, Higuchi K, Arakawa T

    AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY   286 ( 1 )   G148 - G156   2004.01( ISSN:0193-1857

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    DOI: 10.1152/ajpgi.00137.2003

  • Indomethacin, but not Helicobacter pylori, inhibits adaptive relaxation in isolated guinea-pig stomach Reviewed

    Higuchi K, Tominaga K, Watanabe T, Uno H, Shiba M, Sasaki E, Tanigawa T, Takashima T, Hamaguchi M, Oshitani N, Matsumoto T, Iwanaga Y, Fukuda T, Fujiwara Y, Arakawa T

    DRUGS UNDER EXPERIMENTAL AND CLINICAL RESEARCH   30 ( 5-6 )   235 - 241   2004( ISSN:0378-6501

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  • Safety and efficacy of S-1, a novel oral fluorouracil antitumor drug, for a chronic renal failure patient maintained on hemodialysis Reviewed

    Tominaga K, Higuchi K, Okazaki H, Suto R, Hamaguchi M, Tanigawa T, Sasaki E, Shiba M, Watanabe T, Fujiwara Y, Oshitani N, Matsumoto T, Arakawa T

    ONCOLOGY   66 ( 5 )   358 - 364   2004( ISSN:0030-2414

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    DOI: 10.1159/000079483

  • COX-2 is essential for EGF induction of cell proliferation in gastric RGM1 cells Reviewed

    Sasaki E, Tominaga K, Watanabe T, Fujiwara Y, Oshitani N, Matsumoto T, Higuchi K, Tarnawski AS, Arakawa T

    DIGESTIVE DISEASES AND SCIENCES   48 ( 12 )   2257 - 2262   2003.12( ISSN:0163-2116

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  • Esophagogastric varices due to arterioportal shunt in a serous cystadenoma of the pancreas in von Hippel-Lindau disease Reviewed

    Okuyama M, Fujiwara Y, Hayakawa T, Shiba M, Watanabe T, Tominaga K, Tamori A, Oshitani N, Higuchi K, Matsumoto T, Nakamura K, Wakasa K, Hirohashi K, Ashida S, Shuin T, Arakawa T

    DIGESTIVE DISEASES AND SCIENCES   48 ( 10 )   1948 - 1954   2003.10( ISSN:0163-2116

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  • Cigarette smoking and alcohol consumption associated with gastro-oesophageal reflux disease in Japanese men Reviewed

    Watanabe Y, Fujiwara Y, Shiba M, Watanabe T, Tominaga K, Oshitani N, Matsumoto T, Nishikawa H, Higuchi K, Arakawa T

    SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY   38 ( 8 )   807 - 811   2003.08( ISSN:0036-5521

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    DOI: 10.1080/00365520310004506

  • Comparison of the effects of rebamipide with those of cimetidine on chronic gastritis associated with Helicobacter pylori in Mongolian gerbils Reviewed

    Higuchi K, Tanigawa T, Hamaguchi M, Takashima T, Sasaki E, Shiba M, Tominaga K, Fujiwara Y, Oshitani N, Matsumoto T, Watanabe T, Arakawa T

    ALIMENTARY PHARMACOLOGY & THERAPEUTICS   18   1 - 7   2003.07( ISSN:0269-2813

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  • Is eradication sufficient to heal gastric ulcers in patients infected with Helicobacter pylori? A randomized, controlled, prospective study Reviewed

    Higuchi K, Fujiwara Y, Tominaga K, Watanabe T, Shiba M, Nakamura S, Oshitani N, Matsumoto T, Arakawa T

    ALIMENTARY PHARMACOLOGY & THERAPEUTICS   17 ( 1 )   111 - 117   2003.01( ISSN:0269-2813

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    DOI: 10.1046/j.0269-2813.2003.01402.x

  • No additive effect between Helicobacter pylori infection and portal hypertensive gastropathy on inducible nitric oxide synthase expression in gastric mucosa of cirrhotic patients Reviewed

    Arafa UA, Fujiwara Y, Higuchi K, Shiba M, Uchida T, Watanabe T, Tominaga K, Oshitani N, Matsumoto T, Arakawa T

    DIGESTIVE DISEASES AND SCIENCES   48 ( 1 )   162 - 168   2003.01( ISSN:0163-2116

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  • Association between gastroesophageal flap valve, reflux esophagitis, Barrett's epithelium, and atrophic gastritis assessed by endoscopy in Japanese patients Reviewed

    Fujiwara Y, Higuchi K, Shiba M, Watanabe T, Tominaga K, Oshitani N, Matsumoto T, Arakawa T

    JOURNAL OF GASTROENTEROLOGY   38 ( 6 )   533 - 539   2003( ISSN:0944-1174

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    DOI: 10.1007/s00535-002-1100-9

  • Increased expression of cytokines and adhesion molecules in rat chronic esophagitis Reviewed

    Hamaguchi M, Fujiwara Y, Takashima T, Hayakawa T, Sasaki E, Shiba M, Watanabe T, Tominaga K, Oshitani N, Matsumoto T, Higuchi K, Arakawa T

    DIGESTION   68 ( 4 )   189 - 197   2003( ISSN:0012-2823

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    DOI: 10.1159/000075698

  • Ulcerogenic influence of selective cyclooxygenase-2 inhibitors in the rat stomach with adjuvant-induced arthritis Reviewed

    Kato S, Ogawa Y, Kanatsu K, Okayama M, Watanabe T, Arakawa T, Takeuchi K

    JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS   303 ( 2 )   503 - 509   2002.11( ISSN:0022-3565

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    DOI: 10.1124/jpet.102.040659

  • In vivo action of novel alkyl methyl quinolone alkaloids against Helicobacter pylori Reviewed

    Tominaga K, Higuchi K, Hamasaki N, Hamaguchi M, Takashima T, Tanigawa T, Watanabe T, Fujiwara Y, Tezuka Y, Nagaoka T, Kadota S, Ishii E, Kobayashi K, Arakawa T

    JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY   50 ( 4 )   547 - 552   2002.10( ISSN:0305-7453

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    DOI: 10.1093/jac/dkf159

  • Rebamipide prevents delay of acetic acid-induced gastric ulcer healing caused by Helicobacter pylori infection in Mongolian gerbils Reviewed

    Watanabe T, Higuchi K, Hamaguchi M, Tanigawa T, Wada R, Tominaga K, Fujiwara Y, Arakawa T

    DIGESTIVE DISEASES AND SCIENCES   47 ( 7 )   1582 - 1589   2002.07( ISSN:0163-2116

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  • High molecular protein of Helicobacter pylori responsible for inhibition of ornithine decarboxylase activity of human gastric cultured cells Reviewed

    Takashima T, Fujiwara Y, Watanabe T, Tominaga K, Oshitani N, Higuchi K, Matsumoto T, Arakawa T, Hasuma T, Yano Y, Otani S

    ALIMENTARY PHARMACOLOGY & THERAPEUTICS   16   167 - 173   2002.04( ISSN:0269-2813

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  • Increased expression of epidermal growth factor receptors in basal cell hyperplasia of the oesophagus after acid reflux oesophagitis in rats Reviewed

    Fujiwara Y, Higuchi K, Takashima T, Hamaguchi M, Watanabe T, Tominaga K, Oshitani N, Matsumoto T, Arakawa T

    ALIMENTARY PHARMACOLOGY & THERAPEUTICS   16   52 - 58   2002.04( ISSN:0269-2813

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  • Effects of ecabet sodium, an antiulcer drug, on gastric adaptive relaxation in isolated guinea-pig stomachs Reviewed

    Higuchi K, Tominaga K, Uno H, Yasuda M, Hashiume M, Matsumoto M, Watanabe T, Fujiwara Y, Oshitani N, Matsumoto T, Arakawa T

    DRUGS UNDER EXPERIMENTAL AND CLINICAL RESEARCH   28 ( 2-3 )   105 - 111   2002( ISSN:0378-6501

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  • Long-term effect of Helicobacter pylori eradication on quality of life, body mass index, and newly developed diseases in Japanese patients with peptic ulcer disease Reviewed

    Fujiwara Y, Higuchi K, Arafa UA, Uchida T, Tominaga K, Watanabe T, Arakawa T

    HEPATO-GASTROENTEROLOGY   49 ( 47 )   1298 - 1302   2002( ISSN:0172-6390

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  • Mechanisms and roles of neutrophil infiltration in stress-induced gastric injury in rats Reviewed

    Hamaguchi M, Watanabe T, Higuchi K, Tominaga K, Fujiwara Y, Arakawa T

    DIGESTIVE DISEASES AND SCIENCES   46 ( 12 )   2708 - 2715   2001.12( ISSN:0163-2116

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  • Risk associated with reprocessed reusable endoscopic instruments Reviewed

    Shiba M, Higuchi K, Fujiwara Y, Tominaga K, Watanabe T, Itani A, Oshitani N, Matsumoto T, Arakawa T

    AMERICAN JOURNAL OF GASTROENTEROLOGY   96 ( 12 )   3465 - 3467   2001.12( ISSN:0002-9270

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  • Sildenafil-induced esophageal ulcers Reviewed

    Higuchi K, Ando K, Kim SR, Fujiwara Y, Tominaga K, Watanabe T, Shiba M, Oshitani N, Matsumoto T, Arakawa T

    AMERICAN JOURNAL OF GASTROENTEROLOGY   96 ( 8 )   2516 - 2518   2001.08( ISSN:0002-9270

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  • Acid regulates inflammatory response in a rat model of induction of gastric ulcer recurrence by interleukin 1 beta Reviewed

    Watanabe T, Higuchi K, Tominaga K, Fujiwara Y, Arakawa T

    GUT   48 ( 6 )   774 - 781   2001.06( ISSN:0017-5749

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  • Combined balloon-occluded embolization for treatment of concurrent duodenal, gastric, and esophageal varices: a case report Reviewed

    Tominaga K, Montani A, Kuga T, Shiba M, Watanabe T, Fujiwara Y, Uchida T, Saeki Y, Higuchi K, Nakamura K, Arakawa T, Yamada R

    GASTROINTESTINAL ENDOSCOPY   53 ( 6 )   665 - 668   2001.05( ISSN:0016-5107

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  • Association between gastroesophageal flap valve, reflux esophagitis, Barrett's epithelium, and atrophic gastritis assessed by endoscopy in Japanese patients. Reviewed

    Fujiwara Y, Higuchi K, Tominaga K, Watanabe T, Arafa UA, Uchida T, Arakawa T

    GASTROINTESTINAL ENDOSCOPY   53 ( 5 )   AB142 - AB142   2001.04( ISSN:0016-5107

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  • Neutrophils delay gastric ulcer healing by inhibiting angiogenesis in rats: Involvement of antiangiogenic effect of tumor necrosis factor-alpha. Reviewed

    Watanabe T, Higuchi K, Hamaguchi M, Tominaga K, Fujiwara Y, Arakawa T

    GASTROENTEROLOGY   120 ( 5 )   A148 - A148   2001.04( ISSN:0016-5085

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  • Marked enhancement of gastric ulcer healing by peroxisome proliferator-activated receptor gamma ligands in rats Reviewed

    Hamaguchi M, Watanabe T, Higuchi K, Tominaga K, Fujiwara Y, Arakawa T

    GASTROENTEROLOGY   120 ( 5 )   A149 - A149   2001.04( ISSN:0016-5085

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  • Induction of gastric lesions by cyclooxygenase (COX-2) inhibitors in the stomach of adjuvant-induced arthritic rats Reviewed

    Kato S, Ogawa Y, Kunikata T, Watanabe T, Arakawa T, Takeuchi K

    GASTROENTEROLOGY   120 ( 5 )   A143 - A144   2001.04( ISSN:0016-5085

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  • Indomethacin, but not H. pylori, inhibited adaptive relaxation in isolated guinea-pig stomachs. Reviewed

    Fukuda T, Arakawa T, Uno H, Higuchi K, Tominaga K, Watanabe T, Iwanaga Y

    GASTROENTEROLOGY   120 ( 5 )   A461 - A461   2001.04( ISSN:0016-5085

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  • Epidermal growth factor protects human esophageal epithelial cells against acid-induced damage through the activation of Na+/H+ exchangers Reviewed

    Fujiwara Y, Higuchi K, Takashima T, Tominaga K, Watanabe T, Arakawa T

    GASTROENTEROLOGY   120 ( 5 )   A145 - A145   2001.04( ISSN:0016-5085

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  • Effect of Helicobacter pylori infection on expression of inducible nitric oxide synthase in gastric mucosa of patients with liver cirrhosis Reviewed

    Arafa UA, Fujiwara Y, Uchida T, Watanabe T, Tominaga K, Higuchi K, Arakawa T

    GASTROENTEROLOGY   120 ( 5 )   A709 - A709   2001.04( ISSN:0016-5085

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  • Expression of gene for EIIIA- and EIIIB-fibronectin, fetal types of fibronectin, during gastric ulcer healing in rats Reviewed

    Tominaga K, Higuchi K, Watanabe T, Fujiwara Y, Kim S, Arakawa T, Iwao H, Kuroki T

    DIGESTIVE DISEASES AND SCIENCES   46 ( 2 )   311 - 317   2001.02( ISSN:0163-2116

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  • Effect of Helicobacter pylori culture supernatant on acute reflux esophagitis in a rat model Reviewed

    Fujiwara Y, Higuchi K, Tominaga K, Matsuo T, Watanabe T, Uchida T, Saeki Y, Arakawa T, Fujiwara Y

    HEPATO-GASTROENTEROLOGY   48 ( 42 )   1611 - 1615   2001( ISSN:0172-6390

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  • Inhibitory effect of sofalcone on tumor necrosis factor-alpha and interleukin-1 beta production in human monocytes stimulated by Helicobacter pylori water extract Reviewed

    Fujiwara Y, Higuchi K, Fukuda T, Watanabe T, Tominaga K, Arakawa T

    DRUGS UNDER EXPERIMENTAL AND CLINICAL RESEARCH   27 ( 3 )   103 - 106   2001( ISSN:0378-6501

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  • Immuno-inflammatory responses in recurrence of ulcer: Role of inflammatory cytokines and acid. Reviewed

    Arakawa T, Higuchi K, Watanabe T, Tominaga K, Fujiwara Y

    PROCEEDINGS OF THE SOCIETY FOR EXPERIMENTAL BIOLOGY AND MEDICINE   225 ( 2 )   161 - 161   2000.11( ISSN:0037-9727

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  • Secondary esophageal tuberculosis in a patient with thymoma Reviewed

    Tominaga K, Higuchi K, Watanabe T, Fujiwara Y, Uchida T, Arakawa T, Kuroki T

    GASTROINTESTINAL ENDOSCOPY   52 ( 4 )   543 - 545   2000.10( ISSN:0016-5107

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  • Neutrophil accumulation in development of gastric ulcer induced by submucosal injection of endothelin-1 in rats Reviewed

    Watanabe T, Arakawa T, Tominaga K, Fujiwara Y, Higuchi K, Kuroki T

    DIGESTIVE DISEASES AND SCIENCES   45 ( 5 )   880 - 888   2000.05( ISSN:0163-2116

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  • Both gastric acid and neutrophil infiltration are required for development of stress-induced gastric mucosal injuries in rats. Reviewed

    Higuchi K, Hamaguchi M, Watanabe T, Tominaga K, Uchida T, Fujiwara Y, Arakawa T

    GASTROENTEROLOGY   118 ( 4 )   A1246 - A1246   2000.04( ISSN:0016-5085

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  • No relation was found between inflammation and intestinal metaplasia of gastric mucosa and the development of gastroesophageal reflux disease among Japanese patients. Reviewed

    Uchida T, Fujiwara Y, Matsuo T, Tominaga K, Watanabe T, Saeki Y, Arafa UA, Higuchi K, Arakawa T

    GASTROENTEROLOGY   118 ( 4 )   A1317 - A1317   2000.04( ISSN:0016-5085

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  • Neutrophils at the early phase of healing serve as a significant source of tumor necrosis factor-A and delay healing of experimental gastric ulcer. Reviewed

    Arakawa T, Watanabe T, Shimizu N, Tominaga K, Fujiwara Y, Higuchi K

    GASTROENTEROLOGY   118 ( 4 )   A231 - A231   2000.04( ISSN:0016-5085

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  • Induction of signal transduction pathways in rat gastric epithelial cells stimulated with interleukin-1 beta Reviewed

    Tominaga K, Higuchi K, Tsuno M, Watanabe T, Fujiwara Y, Kim S, Arakawa T, Iwao H, Kuroki T

    ALIMENTARY PHARMACOLOGY & THERAPEUTICS   14   101 - 108   2000.04( ISSN:0269-2813

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  • Histological estimation of the efficacy of endoscopic laser coagulation therapy for diffuse antral vascular ectasia Reviewed

    Tominaga K, Arakawa T, Taguchi M, Kuga T, Ando K, Shiba M, Watanabe T, Takaishi O, Fujiwara Y, Uchida T, Higuchi K, Kuroki T

    EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY   12 ( 4 )   469 - 472   2000.04( ISSN:0954-691X

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  • Has Helicobacter pylori eradication for large gastric ulcers been overrated? Reviewed

    Higuchi K, Arakawa T, Fujiwara Y, Tominaga K, Watanabe T, Uchida T, Kuroki T

    GASTROENTEROLOGY   118 ( 4 )   A497 - A497   2000.04( ISSN:0016-5085

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  • Gastric acid reflux triggers activation of epidermal growth factor receptor gene and proliferation in injured esophageal mucosa in rats. Reviewed

    Fujiwara Y, Higuchi K, Takashima T, Uchida T, Watanabe T, Tominaga K, Arakawa T, Tarnawski AS

    GASTROENTEROLOGY   118 ( 4 )   A1235 - A1235   2000.04( ISSN:0016-5085

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  • Follicle-associated epithelium of the gastric mucosae infected with Helicobacter pylori in Mongolian gerbils. Reviewed

    Wada R, Watanabe T, Hamasaki N, Tominaga K, Fujiwara Y, Higuchi K, Arakawa T, Kaneda K

    GASTROENTEROLOGY   118 ( 4 )   A747 - A747   2000.04( ISSN:0016-5085

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  • Does eradication of Helicobacter pylori predispose to hyperlipidemia in patients with peptic ulcer disease? Reviewed

    Fujiwara Y, Higuchi K, Uchida T, Arafa UA, Watanabe T, Kazunari T, Arakawa T, Kuroki T

    GASTROENTEROLOGY   118 ( 4 )   A1235 - A1235   2000.04( ISSN:0016-5085

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  • Roles of angiotensin II in acute gastric mucosal injuries in rats: Involvement of angiotensin II type I receptor. Reviewed

    Watanabe T, Higuchi K, Hamaguchi M, Tominaga K, Fujiwara Y, Arakawa T

    GASTROENTEROLOGY   118 ( 4 )   A1321 - A1321   2000.04( ISSN:0016-5085

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  • Unique antibacterial mechanism(S) and in vivo efficacy of novel alkyl quinolone alkaloids against Helicobacter pylori. Reviewed

    Tominaga K, Higuchi K, Hamasaki N, Watanabe T, Fujiwara Y, Ishii E, Tezuka Y, Nagaoka T, Kadota S, Arakawa T

    GASTROENTEROLOGY   118 ( 4 )   A502 - A502   2000.04( ISSN:0016-5085

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  • TNF-A is a key cytokine in the pathogenesis of stress-induced gastropathy in rats. Reviewed

    Hamaguchi M, Higuchi K, Watanabe T, Tominaga K, Uchida T, Fujiwara Y, Arakawa T

    GASTROENTEROLOGY   118 ( 4 )   A1243 - A1243   2000.04( ISSN:0016-5085

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  • Oesophageal cavernous haemangioma diagnosed histologically, not by endoscopic procedures Reviewed

    Tominaga K, Arakawa T, Ando K, Umeda S, Shiba M, Suzuki N, Watanabe T, Takaishi O, Fujiwara Y, Uchida T, Fukuda T, Higuchi K, Kuroki T

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   15 ( 2 )   215 - 219   2000.02( ISSN:0815-9319

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  • Cytoprotective effect of rabeprazole against ethanol-induced gastric mucosal damage: Possible involvement of nitric oxide Reviewed

    Watanabe T, Higuchi K, Tominaga K, Fujiwara Y, Arakawa T

    DRUGS UNDER EXPERIMENTAL AND CLINICAL RESEARCH   26 ( 2 )   41 - 45   2000( ISSN:0378-6501

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  • Pentoxifylline accelerates gastric ulcer healing in rats: Roles of tumor necrosis factor alpha and neutrophils during the early phase of ulcer healing Reviewed

    Shimizu N, Watanabe T, Arakawa T, Fujiwara Y, Higuchi K, Kuroki T

    DIGESTION   61 ( 3 )   157 - 164   2000( ISSN:0012-2823

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  • Effect of culture conditions on morphological changes of Helicobacter pylori Reviewed

    Tominaga K, Hamasaki N, Watanabe T, Uchida T, Fujiwara Y, Takaishi O, Higuchi K, Arakawa T, Ishii E, Kobayashi K, Yano I, Kuroki T

    JOURNAL OF GASTROENTEROLOGY   34   28 - 31   1999.12( ISSN:0944-1174

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    Publishing type:Research paper (scientific journal)  

  • Endoscopic resection of two granular cell tumours of the oesophagus Reviewed

    Fujiwara Y, Watanabe T, Hamasaki N, Wada T, Shiba M, Uchida T, Takaishi O, Tominaga K, Higuchi K, Fukuda T, Arakawa T, Kuroki T

    EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY   11 ( 12 )   1413 - 1416   1999.12( ISSN:0954-691X

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  • Is Helicobacter pylori-negative duodenal ulcer masked by the high prevalence of H-pylori infection in the general population? Reviewed

    Higuchi K, Arakawa T, Fujiwara Y, Uchida T, Tominaga K, Watanabe T, Kuroki T

    AMERICAN JOURNAL OF GASTROENTEROLOGY   94 ( 10 )   3083 - 3084   1999.10( ISSN:0002-9270

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    Publishing type:Research paper (scientific journal)  

  • Complete regression of recurrent esophageal carcinoma with reduced expression of glutathione S-transferase-pi by treatment with continuous infusion of 5-fluorouracil and low-dose cisplatin infusion Reviewed

    Tominaga K, Arakawa T, Imano M, Kato M, Hamaguchi Y, Watanabe T, Takaishi O, Fujiwara Y, Fukuda T, Higuchi K, Osugi H, Chono S, Kuroki T

    AMERICAN JOURNAL OF GASTROENTEROLOGY   94 ( 6 )   1664 - 1668   1999.06( ISSN:0002-9270

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    Publishing type:Research paper (scientific journal)  

  • Change in localization of HNRNP S1 proteins C2 and D2 associated with increase in various mRNA levels in the conformational changed fibroblasts during in vitro and in vivo wound healing Reviewed

    Tominaga K, Arakawa T, Shimizu N, Watanabe T, Uchida T, Takaishi O, Fujiwara Y, Higuchi K, Inoue A, Kuroki T

    GASTROENTEROLOGY   116 ( 4 )   A335 - A335   1999.04( ISSN:0016-5085

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  • Relation between portal hypertensive gastropathy and Helicobacter pylori colonization in Japanese patients with liver cirrhosis arising from hepatitis B or C virus Reviewed

    Higuchi K, Arakawa T, Uchida T, Shiba M, Hamasaki N, Kuga T, Ando K, Watanabe T, Tominaga K, Takaishi O, Fujiwara Y, Kobayashi K

    GASTROINTESTINAL ENDOSCOPY   49 ( 4 )   AB166 - AB166   1999.04( ISSN:0016-5107

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    Publishing type:Research paper (scientific journal)  

  • Rebamipide accelerates healing of gastric ulcer in mongolian gerbils infected with Helicobacter pylori Reviewed

    Arakawa T, Watanabe T, Wada R, Hamasaki N, Tominaga K, Takaishi O, Fujiwara Y, Higuchi K, Kuroki T

    GASTROENTEROLOGY   116 ( 4 )   A114 - A114   1999.04( ISSN:0016-5085

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    Publishing type:Research paper (scientific journal)  

  • Possible role of adhesion molecules in stress-induced gastropathy Reviewed

    Higuchi K, Hamaguchi M, Watanabe T, Tominaga K, Uchida T, Takaishi O, Fujiwara Y, Arakawa T, Kuroki T

    GASTROENTEROLOGY   116 ( 4 )   A187 - A187   1999.04( ISSN:0016-5085

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    Publishing type:Research paper (scientific journal)  

  • Pentoxifylline accelerates gastric ulcer healing in rats: Role of tumor necrosis factor-A and neutrophils at the early phase of ulcer healing Reviewed

    Shimizu N, Arakawa T, Watanabe T, Tominago K, Takaishi O, Fujiwara Y, Higuchi K, Kuroki T

    GASTROENTEROLOGY   116 ( 4 )   A310 - A310   1999.04( ISSN:0016-5085

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    Publishing type:Research paper (scientific journal)  

  • Newly purified compounds of two quinolone alkaloids from 'Gosyu-yu' have a specific antibacterial activity against Helicobacter pylori Reviewed

    Hamasaki N, Arakawa T, Tominaga K, Watanabe T, Fujiwara Y, Higuchi K, Kuroki T, Ishii E, Tezuka Y, Nagaoka T, Kadota S, Yano I

    GASTROENTEROLOGY   116 ( 4 )   A181 - A181   1999.04( ISSN:0016-5085

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  • Helicobacter pylori-negative duodenal ulcer disease in Japan Reviewed

    Arakawa T, Fujiwara Y, Uchida T, Takaishi O, Tominaga K, Watanabe T, Higuchi K, Kobayashi K, Kuroki K

    GASTROENTEROLOGY   116 ( 4 )   A113 - A113   1999.04( ISSN:0016-5085

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  • Helicobacter pylori in peptic ulcer disease: A criminal or an innocent bystander? Reviewed

    Arakawa T, Fujiwara Y, Uchida T, Takaishi O, Tominaga K, Watanabe T, Higuchi K, Kobayashi K, Kuroki K

    GASTROENTEROLOGY   116 ( 4 )   A113 - A113   1999.04( ISSN:0016-5085

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  • Effect of Helicobacter pylori culture supernatant on acute reflux esophagitis in a rat model. Reviewed

    Fujiwara Y, Tominaga K, Metsuo T, Watanabe T, Uchida T, Higuchi K, Arakawa T, Kuroki T, Tamawaki A

    GASTROENTEROLOGY   116 ( 4 )   A165 - A165   1999.04( ISSN:0016-5085

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    Publishing type:Research paper (scientific journal)  

  • Different roles for neutrophils in the pathogenesis of NSAID-induced and stress-induced gastropathy Reviewed

    Arakawa T, Higuchi K, Hamaguchi M, Watanabe T, Tominaga K, Uchida T, Takaishi O, Fujiwara Y, Kuroki T

    GASTROENTEROLOGY   116 ( 4 )   A113 - A113   1999.04( ISSN:0016-5085

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  • Roles of gastric acid during the development of gastric ulcer recurrence caused by interleukin-1 beta in rats Reviewed

    Watanabe T, Arakawa T, Higuchi K, Shimizu N, Tominaga K, Fujiwara Y, Takaishi O, Kuroki T

    GASTROENTEROLOGY   116 ( 4 )   A351 - A351   1999.04( ISSN:0016-5085

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    Publishing type:Research paper (scientific journal)  

  • Endoscopic ultrasonography images of gastric mucosa-associated lymphoid tissue type (MALT) lymphoma after Helicobacter pylori eradication Reviewed

    Fujiwara Y, Tominaga K, Watanabe T, Ohtani K, Uchida T, Takaishi O, Higuchi K, Fukuda T, Arakawa T, Kuroki T

    ENDOSCOPY   31 ( 2 )   S3 - S3   1999.02( ISSN:0013-726X

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    Publishing type:Research paper (scientific journal)  

  • Gastroprotection by Liu-Jun-Zi-Tang (TJ-43): Possible mediation of nitric oxide but not prostaglandins or sulfhydryls Reviewed

    Arakawa T, Higuchi K, Fujiwara Y, Watanabe T, Tominaga K, Hayakawa T, Kuroki T

    DRUGS UNDER EXPERIMENTAL AND CLINICAL RESEARCH   25 ( 5 )   207 - 210   1999( ISSN:0378-6501

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  • Increased mRNA levels of transforming growth factor-beta 1 and monocyte chemoattractant protein-1 in ulcer relapse caused by interleukin-1 beta in rats Reviewed

    Tominaga K, Arakawa T, Watanabe T, Tanaka M, Takaishi O, Fujiwara Y, Fukuda T, Higuchi K, Kim S, Yamasaki K, Iwao H, Kobayashi K, Kuroki T

    DIGESTIVE DISEASES AND SCIENCES   43 ( 9 )   134S - 138S   1998.09( ISSN:0163-2116

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  • Protective effect of rebamipide against ammonia-induced gastric mucosal lesions Reviewed

    Takaishi O, Arakawa T, Yamasaki K, Fujiwara Y, Uchida T, Tominaga K, Watanabe T, Higuchi K, Fukuda T, Kobayashi K, Kuroki T

    DIGESTIVE DISEASES AND SCIENCES   43 ( 9 )   78S - 82S   1998.09( ISSN:0163-2116

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    Publishing type:Research paper (scientific journal)  

  • Ulcer recurrence - Cytokines and inflammatory response-dependent process Reviewed

    Arakawa T, Watanabe T, Fukuda T, Higuchi K, Fujiwara Y, Kobayashi K, Tarnawski A

    DIGESTIVE DISEASES AND SCIENCES   43 ( 9 )   61S - 66S   1998.09( ISSN:0163-2116

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  • Inhibition by rebamipide of proinflammatory cytokine production by human monocytes stimulated with Helicobacter pylori without prostaglandin. Reviewed

    Fukuda T, Arakawa T, Watanabe T, Tominaga K, Takaishi O, Fujiwara Y, Higuchi K, Kobayashi K, Kuroki T

    GASTROENTEROLOGY   114 ( 4 )   A125 - A125   1998.04( ISSN:0016-5085

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    Publishing type:Research paper (scientific journal)  

  • Effect of omeprazole and amoxicillin plus Goshuyu-to on the eradication of Helicobacter pylori. Reviewed

    Higuchi K, Arakawa T, Ando K, Shiba S, Hamazaki K, Uno H, Watanabe T, Tominaga K, Fujiwara Y, Takaishi O, Uchida T, Ito H, Fukuda T, Yamasaki K, Ishii E, Kobayashi K

    GASTROENTEROLOGY   112 ( 4 )   A148 - A148   1997.04( ISSN:0016-5085

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  • Increased gene expression of transforming growth factor-beta 1 and macrophage chemotacting protein-1 in ulcer relapse caused by interleukin 1 beta in rats. Reviewed

    Tominaga K, Arakawa T, Watanabe T, Tanaka M, Takaishi O, Fujiwara Y, Fukuda T, Higuchi K, Kim S, Yamasaki K, Iwao H, Kobayashi K

    GASTROENTEROLOGY   112 ( 4 )   A313 - A313   1997.04( ISSN:0016-5085

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  • Epiregulin stimulates proliferation of rabbit cultured gastric cells via tyrosine kinase pathway Reviewed

    Sasaki E, Arakawa T, Fujiwara Y, Kawada N, Watanabe T, Tominaga K, Fukuda T, Higuchi K, Komurasaki T, Kobayashi K

    GASTROENTEROLOGY   112 ( 4 )   A904 - A904   1997.04( ISSN:0016-5085

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  • Role of neutrophils in a rat model of gastric ulcer recurrence caused by interleukin-1 beta Reviewed

    Watanabe T, Arakawa T, Fukuda T, Higuchi K, Kobayashi K

    AMERICAN JOURNAL OF PATHOLOGY   150 ( 3 )   971 - 979   1997.03( ISSN:0002-9440

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  • Indomethacin treatment during initial period of acetic acid-induced rat gastric ulcer healing promotes persistent polymorphonuclear cell-infiltration and increases future ulcer recurrence - Possible mediation of prostaglandins Reviewed

    Arakawa T, Watanabe T, Fukuda T, Higuchi K, Takaishi O, Yamasaki K, Kobayashi K, Tarnawski A

    DIGESTIVE DISEASES AND SCIENCES   41 ( 10 )   2055 - 2061   1996.10( ISSN:0163-2116

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  • Nitric oxide induces apoptosis in gastric mucosal cells in vitro Reviewed

    Fukuda T, Arakawa T, Fujiwara Y, Nakagawa K, Uno H, Watanabe T, Ohtani K, Itani A, Higuchi K, Kobayashi K

    GASTROENTEROLOGY   110 ( 4 )   A111 - A111   1996.04( ISSN:0016-5085

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  • Role of neutrophils in ulcer relapse caused by interleukin 1 beta in rats. Reviewed

    Watanabe T, Arakawa T, Fukuda T, Higuchi K, Kobayashi K

    GASTROENTEROLOGY   110 ( 4 )   A293 - A293   1996.04( ISSN:0016-5085

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    Publishing type:Research paper (scientific journal)  

  • REBAMIPIDE, NOVEL PROSTAGLANDIN-INDUCER, ACCELERATES HEALING AND REDUCES RELAPSE OF ACETIC ACID-INDUCED RAT GASTRIC-ULCER - COMPARISON WITH CIMETIDINE Reviewed

    ARAKAWA T, WATANABE T, FUKUDA T, YAMASAKI K, KOBAYASHI K

    DIGESTIVE DISEASES AND SCIENCES   40 ( 11 )   2469 - 2472   1995.11( ISSN:0163-2116

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  • ZINC-DEFICIENCY DELAYS GASTRIC-ULCER HEALING IN RATS Reviewed

    WATANABE T, ARAKAWA T, FUKUDA T, HIGUCHI K, KOBAYASHI K

    DIGESTIVE DISEASES AND SCIENCES   40 ( 6 )   1340 - 1344   1995.06( ISSN:0163-2116

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  • RELAPSE CAUSED BY INTERLEUKIN-1-BETA OF EXPERIMENTAL GASTRIC-ULCER VIA ICAM-1-DEPENDENT AND LFA-1-DEPENDENT MECHANISM Reviewed

    WATANABE T, ARAKAWA T, FUKUDA T, HIGUCHI K, KOBAYASHI K

    GASTROENTEROLOGY   108 ( 4 )   A254 - A254   1995.04( ISSN:0016-5085

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    Publishing type:Research paper (scientific journal)  

  • EFFECTS OF ENDOTHELIN ON SERUM GASTRIN LEVEL AND ACID-SECRETION IN RATS Reviewed

    SAEKI Y, ARAKAWA T, HIGUCHI K, UNO H, WATANABE T, TOMINAGA K, NAKAMURA S, FUKUDA T, NAGURA H, KOBAYASHI K

    JOURNAL OF CARDIOVASCULAR PHARMACOLOGY   26   S123 - S125   1995( ISSN:0160-2446

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  • ULCEROGENICITY AND EFFECT ON INHIBITION OF PROSTAGLANDIN GENERATION OF INDOMETHACIN FARNESIL, A PRODRUG OF INDOMETHACIN, IN RAT GASTRIC-MUCOSA - COMPARISON WITH INDOMETHACIN OR LOXOPROFEN Reviewed

    ARAKAWA T, FUKUDA T, NAKAGAWA K, HIGUCHI K, WATANABE T, TOMINAGA K, KOBAYASHI K

    DRUGS UNDER EXPERIMENTAL AND CLINICAL RESEARCH   21 ( 3 )   85 - 88   1995( ISSN:0378-6501

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  • EXPRESSION OF ADHESION MOLECULES IN CHRONIC GASTRIC-ULCERS IN RATS Reviewed

    WATANABE T, ARAKAWA T, WATANABE Y, NAKAMURA S, HIGUCHI K, FUKUDA T, KOBAYASHI K

    GASTROENTEROLOGY   106 ( 4 )   A210 - A210   1994.04( ISSN:0016-5085

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  • PROSTAGLANDIN-E1-ANALOG DURING INITIAL PERIOD OF EXPERIMENTAL GASTRIC-ULCER REVERSES INCREASE IN FUTURE ULCER RELAPSE CAUSED BY INDOMETHACIN Reviewed

    ARAKAWA T, WATANABE T, FUKUDA T, HIGUCHI K, TARNAWSKI A, KOBAYASHI K

    GASTROENTEROLOGY   106 ( 4 )   A41 - A41   1994.04( ISSN:0016-5085

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  • INTERACTIONS BETWEEN PROSTACYCLIN, NITRIC-OXIDE, AND ENDOTHELIN IN THE REGULATION OF GASTRIC-MUCOSAL BLOOD-FLOW IN RATS Reviewed

    FUKUDA T, WATANABE T, UNO H, YU H, TOMINAGA K, OTANI K, HIGUCHI K, ARAKAWA T, KOBAYASHI K

    GASTROENTEROLOGY   106 ( 4 )   A234 - A234   1994.04( ISSN:0016-5085

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  • EXPRESSION OF GENE FOR FETAL TYPES OF FIBRONECTIN DURING HEALING OF GASTRIC-ULCERS IN RATS Reviewed

    FUKUDA T, TOMINAGA K, ARAKAWA T, KIM S, WATANABE T, HIGUCHI K, NAKAMURA H, IWAO H, KOBAYASHI K

    GASTROENTEROLOGY   106 ( 4 )   A78 - A78   1994.04( ISSN:0016-5085

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Books and Other Publications

  • 腸内微生物叢最前線―健康・疾病の制御システムを理解する

    渡辺俊雄、藤原靖弘( Role: Joint author ,  非ステロイド系抗炎症薬による小腸粘膜傷害と腸内微生物叢)

    診断と治療社  2021 

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    Total pages:142   Responsible for pages:45-48   Book type:Scholarly book

  • 専門医のための消化器病学(第3版)

    渡邉俊雄、藤原靖弘( Role: Joint author ,  薬剤性腸炎)

    医学書院  2021 

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    Total pages:710   Responsible for pages:185-187   Book type:Scholarly book

  • 腸内微生物叢最前線:非ステロイド性抗炎症薬による小腸粘膜傷害と腸内微生物叢

    渡邉俊雄 藤原靖弘( Role: Joint author)

    診断と治療社  2020.12 

  • 1361専門家による私の治療2019−20年度版: 胃十二指腸潰瘍

    渡邉 俊雄( Role: Sole author)

    日本医事新報社  2019 

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    Responsible for pages:352-353  

  • 薬剤起因性小腸傷害と腸内細菌の関係性

    渡辺俊雄( Role: Sole author ,  第2章疾患を引き起こす、進展させる腸内細菌叢とそのメカニズム第8節薬剤起因性小腸傷害と腸内細菌の関係性)

    科学技術協会  2018.09 

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    Total pages:477   Responsible for pages:93-100   Book type:Scholarly book Participation form:First Author

  • 1336専門家による~私の治療~2017年

    渡辺俊雄、荒川哲男( Role: Joint author ,  胃十二指腸潰瘍)

    日本医事新報社  2017 

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    Responsible for pages:372-373   Book type:Scholarly book

  • レジデント・コンパス消化器病編(監修: 鈴木 秀和, 渡辺 俊雄, 佐々木 誠人)

    渡辺 俊雄( Role: Sole author ,  III病棟編2.消化管腫瘍1)消化管ポリープa)胃ポリープ)

    ライフ・サイエンス  2011  ( ISBN:9784898013755

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    Total pages:219   Responsible for pages:119-120   Book type:Scholarly book

    CiNii Books

  • 別冊 日本臨床 消化管症候群(第2版)

    渡辺俊雄, 荒川哲男( Role: Joint author ,  I食道 37. 食道放線症)

    日本臨床社  2009 

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    Total pages:644   Book type:Scholarly book Participation form:First Author

  • FD診療のてびき

    富永和作, 樋口和秀, 越智正博, 門内かおり, 谷川徹也, 斯波将次, 渡辺俊雄, 藤原靖弘, 押谷伸英,  荒川哲男( Role: Joint author ,  FDの原因と発症機序-運動機能障害,知覚障害,心理的・社会的要因)

    ヴァン メディカル  2008 

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    Book type:Scholarly book

  • プライマリケアの時代の症候の診かた

    富永和作, 谷川徹也, 渡辺俊雄, 藤原靖弘, 押谷伸英, 荒川哲男( Role: Joint author ,  36) 悪心・嘔吐)

    診断と治療社  2008 

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    Book type:Scholarly book

  • Annual Review 消化器2008

    荒川哲男, 富永和作, 渡辺俊雄, 藤原靖弘( Role: Sole author ,  FD-Rome III以来の展開)

    中外医学社  2008 

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    Responsible for pages:35-40   Book type:Scholarly book

  • レジデント・コンパス(監修:鈴木秀和, 渡辺俊雄)

    渡辺俊雄( Role: Sole author)

    ライフ・サイエンス  2006  ( ISBN:4898012396

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    Book type:Scholarly book

    CiNii Books

  • サイトプロテクション-生体防御機構の解明と最先端医療への道

    渡辺俊雄, 樋口和秀, 富永和作, 藤原靖弘, 押谷伸英, 荒川哲男( Role: Sole author ,  情報伝達とサイトプロテクション, cox-2と胃粘膜)

    癌と化学療法社  2006 

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    Total pages:164   Responsible for pages:86-90   Book type:Scholarly book

  • 消化器病学の進歩2005―モノグラフ― 消化管編

    渡辺俊雄, 樋口和秀, 大和正典( Role: Joint author ,  Indomethacin誘発性小腸潰瘍の発生過程におけるToll-like receptor4の役割)

    メディカルレビュー社  2005 

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    Total pages:276   Responsible for pages:219-221   Book type:Scholarly book Participation form:First Author

  • 21世紀の胃の炎症学

    平良高一, 渡辺俊雄, 谷川徹也, 富永和作, 藤原靖弘, 樋口和秀, 荒川哲男( Role: Sole author ,  胃炎に対する防御機構)

    メディカルレビュー社  2005 

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    Total pages:373   Responsible for pages:291-299   Book type:Scholarly book

  • 消化器病学の進歩2005―モノグラフ― 消化器病学のニューフロンティア

    富永和作, 樋口和秀, 門内かおり, 越智正博, 佐々木英二, 斯波将次, 渡辺俊雄, 藤原靖弘, 押谷伸英, 荒川哲男( Role: Sole author ,  六君子湯治療におけるfunctional dyspepsia患者の胃排出能および自覚症状変化)

    メディカルレビュー社  2005 

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    Total pages:415   Responsible for pages:94-97   Book type:Scholarly book

  • GERD治療のQ & A 「胸やけ」症状はどのように理解すべきでしょう

    藤原靖弘, 樋口和秀, 内田俊之, 高石 修, 斯波将次, 富永和作, 渡辺俊雄, 押谷伸英, 松本誉之, 荒川哲男( Role: Joint author ,  GERD治療の新たなストラテジー)

    先端医学社  2004 

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    Responsible for pages:154-155   Book type:Scholarly book

  • ~実地医家のための~Helicobacter pylori除菌方法 Q&A

    荒川哲男, 樋口和秀, 藤原靖弘, 渡辺俊雄, 富永和作( Role: Joint author ,  感染診断と除菌判定の問題点)

    先端医学社  2004 

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    Responsible for pages:31-32   Book type:Scholarly book

  • サイトプロテクション-生体防御機構の源流を探る

    荒川哲男, 樋口和秀, 藤原靖弘, 渡辺俊雄, 富永和作, 押谷伸英, 松本誉之( Role: Joint author ,  IV. 臓器特異的防御特性 COXとプロスタグランジン)

    癌と化学療法社  2002 

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    Total pages:212   Responsible for pages:112-131   Book type:Scholarly book

  • プロトンポンプ阻害薬のすべて

    樋口和秀, 藤原靖弘, 斯波将次, 富永和作, 渡辺俊雄, 内田俊之, 荒川哲男( Role: Joint author ,  Helicobacter pylori 除菌後の長期予後と生活習慣病発症への影響)

    先端医学社  2002 

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    Total pages:284   Responsible for pages:220-223   Book type:Scholarly book

  • 消化器診療ポケットブック

    樋口和秀, 渡辺俊雄, 富永和作, 斯波将次, 内田俊之, 藤原靖弘, 荒川哲男( Role: Joint author ,  上部消化管:胃炎に関わる問題)

    ヴァン メディカル  2002 

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    Total pages:206   Responsible for pages:185-192   Book type:Scholarly book

  • H. pylori時代の消化性潰瘍学

    富永和作, 樋口和秀, 渡辺俊雄, 内田俊之, 藤原靖弘, 荒川哲男( Role: Joint author ,  第XVII編 消化性潰瘍治療薬概要ー除菌治療の立場から)

    日本臨牀社  2002 

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    Total pages:806   Responsible for pages:721-726   Book type:Scholarly book

  • H. pylori時代の消化性潰瘍学

    荒川哲男, 樋口和秀, 松本誉之, 押谷伸英, 藤原靖弘, 富永和作, 渡辺俊雄,( Role: Joint author ,  第XXI編 消化性潰瘍治療の将来)

    日本臨牀社  2002 

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    Total pages:806   Responsible for pages:799-806   Book type:Scholarly book

  • 合併症としての上部消化管疾患治療指針

    渡辺俊雄( Role: Sole author ,  原疾患に合併する消化器症状。2)熱傷・外傷疾患)

    トーレラザール・マッキャン・ヘルスケアワールドワイド  2002 

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    Total pages:57   Responsible for pages:28-29   Book type:Scholarly book Participation form:First Author

  • TECHNICAL TERM消化管

    渡辺俊雄, 樋口和秀( Role: Joint author ,  ストレス潰瘍)

    先端医学社  2002 

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    Total pages:330   Responsible for pages:226-227   Book type:Scholarly book Participation form:First Author

  • 産婦人科の実際

    樋口和秀, 渡辺俊雄, 斯波將次, 富永和作, 藤原靖弘, 荒川哲男( Role: Joint author ,  2. 疼痛 5)胃炎・消化性潰瘍・逆流性食道炎)

    金原出版  2002 

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    Responsible for pages:1605-1614   Book type:Scholarly book Participation form:Second Author

  • Oxidative Stress and Digestive Diseases

    Watanabe T, Higuchi K, Tominaga K, Fujiwara Y, Arakawa T( Role: Joint author ,  Role of neutrophils in development, healing and recurrence of gastric ulcer in rats)

    KARGER  2001 

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    Responsible for pages:41-50   Book type:Scholarly book Participation form:First Author

  • ミレニアム消化器2000

    藤原靖弘, 樋口和秀, 内田俊之, 富永和作, 渡辺俊雄, 荒川哲男( Role: Joint author ,  成人病発症およびQuality of lifeよりみた除菌療法の長期予後)

    日本メディカルセンター  2001 

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    Total pages:199   Responsible for pages:84-86   Book type:Scholarly book

  • 上部消化管内視鏡研修のskill & spirit

    渡辺俊雄( Role: Sole author ,  知識編。3. 胃癌の肉眼分類)

    メディカル朝日  2000 

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    Total pages:77   Responsible for pages:46-49   Book type:Scholarly book Participation form:First Author

  • 基本的な薬の使い方 Consensus & Controversy

    荒川哲男, 樋口和秀, 藤原靖弘, 内田俊之, 佐伯善彦, 富永和作, 渡辺俊雄( Role: Joint author ,  プロスタグランジン製剤)

    診断と治療社  2000 

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    Responsible for pages:256-264   Book type:Scholarly book

  • KEY WORD 2000-2001消化管

    樋口和秀,渡辺俊雄, 荒川哲男, 黒木哲夫( Role: Joint author ,  接着分子)

    先端医学社  1999 

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    Total pages:215   Responsible for pages:128-129   Book type:Scholarly book Participation form:Second Author

  • 領域別症候群 23

    渡辺俊雄, 荒川哲男, 黒木哲夫( Role: Joint author ,  感染症症候群I:食道放線菌症)

    日本臨牀社  1999 

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    Total pages:638   Responsible for pages:500-502   Book type:Scholarly book Participation form:First Author

  • 潰瘍の本質にせまる

    渡辺俊雄( Role: Sole author ,  炎症性サイトカインと出血,穿孔の病態)

    医学図書出版  1999 

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    Total pages:268   Responsible for pages:163-169   Book type:Scholarly book Participation form:First Author

  • 消化器研究の新たな進歩

    内田俊之, 根引浩子, 富永和作,渡辺俊雄,藤原靖弘,佐伯善彦, 樋口和秀,荒川哲男, 黒木哲夫( Role: Joint author ,  H. pylori陰性胃潰瘍とH. pylori除菌後の胃潰瘍再発)

    ヴァン メディカル  1999 

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    Responsible for pages:26-28   Book type:Scholarly book

  • 消化器研究の新たな進歩

    安藤健治, 久我武広, 斯波將次, 樋口和秀, 渡辺俊雄, 富永和作, 内田俊之, 藤原靖弘, 福田隆, 荒川哲男, 黒木哲夫, 高石修, 山崎勝也, 小林絢三( Role: Joint author ,  消化性潰瘍再発に及ぼすH. pylori除菌療法の影響に関する検討)

    ヴァン メディカル  1998 

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    Total pages:95   Responsible for pages:32-35   Book type:Scholarly book

  • Bioregulation and Its Disorders in the Gastrointestinal Tract

    Watanabe T, Arakawa T, Fukuda T, Kuroki T( Role: Joint author ,  Inflammatory cytokines: key factor of ulcer)

    Blackwell Science Japan  1998 

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    Responsible for pages:219-230   Book type:Scholarly book Participation form:First Author

  • Regulation of acid secretion and peptic ulcer formation by inflammatory cytokines

    Arakawa T, Watanabe T, Kobayashi K( Role: Joint author ,  The Immunobiology of H. pylori - From Pathogenesis to Prevention)

    Lippincott Raven Publishers  1997 

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    Responsible for pages:183-190   Book type:Scholarly book Participation form:Second Author

  • 合併症としての上部消化管疾患治療指針

    渡辺俊雄( Role: Sole author ,  原疾患に合併する消化器症状。2)熱傷・外傷疾患)

    スタンダード・マッキンタイヤ  1997 

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    Total pages:54   Responsible for pages:22-23   Book type:Scholarly book Participation form:First Author

  • 消化器病セミナー68 Helicobacter pylori時代の胃疾患の治療

    渡辺俊雄, 荒川哲男( Role: Joint author ,  新しい潰瘍再発モデルとその意義)

    へるす出版  1997 

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    Total pages:162   Responsible for pages:133-142   Book type:Scholarly book Participation form:First Author

  • 消化器疾患の基礎と臨床-最新のあゆみ

    渡辺俊雄, 福田 隆, 荒川哲男( Role: Joint author ,  Ⅰ. 消化管疾患 基礎. 4. 慢性潰瘍再発の機序 C. サイトカインネットワーク)

    東京医学社  1997 

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    Total pages:496   Responsible for pages:68-70   Book type:Scholarly book Participation form:First Author

  • 消化器疾患の基礎と臨床-最新のあゆみ

    荒川哲男, 福田隆, 樋口和秀, 藤原靖弘, 渡辺俊雄, 小林絢三( Role: Joint author ,  Ⅰ. 消化管疾患 基礎. 4. 慢性潰瘍再発の機序 A. 研究のあゆみ)

    東京医学社  1997 

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    Total pages:496   Responsible for pages:61-63   Book type:Scholarly book

  • 消化器疾患の基礎と臨床-最新のあゆみ

    荒川哲男, 渡辺俊雄, 小林絢三( Role: Joint author ,  Ⅰ. 消化管疾患 基礎. 4. 慢性潰瘍再発の機序 B. プロスタグランジン欠乏)

    東京医学社  1997 

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    Total pages:496   Responsible for pages:64-68   Book type:Scholarly book Participation form:Second Author

  • 消化器病態学の最前線

    荒川哲男, 渡辺俊雄, 福田 隆, 樋口和秀, 小林絢三( Role: Joint author ,  潰瘍再発のメカニズムからみたQOUHの意義)

    杏林書院  1996 

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    Total pages:391   Responsible for pages:310-320   Book type:Scholarly book Participation form:Second Author

  • プロスタグランジンと消化性潰瘍

    渡辺俊雄, 福田 隆, 荒川哲男, 小林絢三( Role: Joint author ,  10)H2ブロッカー抵抗性潰瘍 病態)

    医薬ジャーナル  1994 

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    Total pages:154   Responsible for pages:134-135   Book type:Scholarly book Participation form:First Author

  • 領域別症候群 5 消化管症候群(上巻)

    渡辺俊雄, 樋口和秀, 荒川哲男, 小林絢三( Role: Joint author ,  食道放線菌症)

    日本臨牀社  1994 

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    Total pages:826   Responsible for pages:166-167   Book type:Scholarly book Participation form:First Author

  • QOUHの評価をめぐって - 消化性潰瘍の最前線 -

    荒川哲男, 福田 隆, 渡辺俊雄, 小林絢三( Role: Joint author ,  酢酸潰瘍モデルにみるQOUH)

    東京医学社  1993 

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    Total pages:116   Responsible for pages:11-19   Book type:Scholarly book Participation form:Second Author

▼display all

MISC

  • 【胃内細菌叢の最新の話題を知る】Helicobacter pylori除菌後でも残存するdysbiosisについて Reviewed

    灘谷 祐二, 渡邉 俊雄

    Helicobacter Research   27 ( 2 )   159 - 162   2023.12( ISSN:1342-4319

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    日本では,Helicobacter pylori(H.pylori)除菌治療が保険適用となったことにより除菌後症例が増加してきている.それに伴い,除菌後胃がんが注目されてきている.最近のさまざまな研究により,当然H.pyloriが胃がん発症の危険因子であることは疑いがないが,それ以外の胃細菌叢も胃発がんに対して影響を与えることが明らかになってきた.われわれの報告した胃がん治療症例を対象におこなったH.pylori除菌前後の胃細菌叢の研究では,α多様性などの変化を伴う胃のdysbiosisは,除菌後長期間経過しても顕著な改善がみられなかった.この研究は除菌後胃がんの高リスク群を対象にしていることより,除菌後に持続していた胃dysbiosisが除菌後胃発がんの病態に関与している可能性を示唆していると考えている.(著者抄録)

  • 【Helicobacter pylori除菌後胃癌のいま】除菌後胃癌と胃内細菌叢 Reviewed

    渡邉 俊雄, 灘谷 祐二

    Helicobacter Research   27 ( 1 )   66 - 70   2023.06( ISSN:1342-4319

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    Helicobacter pylori除菌治療の普及に伴い,除菌後胃癌に対する関心が高まっている.現時点では臨床疫学的な検討が中心であるが,分子生物学的な手法を用いた病態解析もおこなわれるようになっている.胃癌モデル動物を用いた検討では,胃癌発症にはH.pyloriが第一義的に重要であるものの,H.pylori以外の胃内共生細菌も発癌過程に関与している可能性が示されている.早期胃癌内視鏡治療症例を対象におこなった検討では,α多様性やBlautiaやFaecalibacteriumの減少に特徴付けられるH.pylori惹起性胃dysbiosisは,除菌後長期間経過しても顕著な改善がみられなかった.これらの症例は除菌後胃癌の高リスク群であることから,持続的なdysbiosisが除菌後胃発癌の病態に関与している可能性が想定される.(著者抄録)

  • 【PPIの功罪(PCABを含む)】抗血栓剤,NSAIDs使用者に対するPPI治療の注意点 Reviewed

    渡邉 俊雄

    日本内科学会雑誌   112 ( 1 )   32 - 38   2023.01( ISSN:0021-5384

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  • ストレス負荷マウスの腸管バリアに対するプロトンポンプ阻害剤の影響について Reviewed

    高嶋 信吾, 灘谷 祐二, 東森 啓, 大谷 恒史, 田中 史生, 渡邉 俊雄, 藤原 靖弘

    日本ヘリコバクター学会誌   24 ( 2 )   117 - 119   2023.01( ISSN:2187-8005

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  • 【Helicobacter Year Book 2022-Helicobacter研究はここまで進展した-】Helicobacter pylori感染と非悪性疾患とのかかわり Reviewed

    大谷 恒史, 渡邉 俊雄

    Helicobacter Research   26 ( 2 )   157 - 161   2022.12( ISSN:1342-4319

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    Helicobacter pyloriに関連する非悪性胃外疾患としては鉄欠乏性貧血,ビタミンB12欠乏性貧血の他,一次性免疫性血小板減少症による血小板低下があり,非悪性胃疾患としては胃炎以外に,薬剤性潰瘍を含む消化性潰瘍,過形成性ポリープ,ディスペプシアがある.非ステロイド性抗炎症薬の長期内服を予定している場合には,除菌治療は消化性潰瘍の発症予防に有用である.またディスペプシアについては,除菌6ヵ月〜1年後に症状の改善が持続するものはH.pylori関連ディスペプシアといい,機能性ディスペプシアとは異なるが,両者を事前に区別することはできないため,まずは除菌治療を考慮する.(著者抄録)

  • 何でも答えます!Helicobacter pylori感染症(No 18) 抗凝固薬や抗血小板薬を服用している患者さんに除菌治療をおこなう場合、注意すべきことはありますか? Reviewed

    灘谷 祐二, 高嶋 信吾, 渡邉 俊雄

    Helicobacter Research   26 ( 1 )   113 - 115   2022.06( ISSN:1342-4319

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  • 非ステロイド系抗炎症薬による消化管傷害の病態と治療 Reviewed

    渡邉 俊雄

    大阪市医学会雑誌   70   23 - 31   2021.12( ISSN:0386-4103

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    低用量アスピリンを含む非ステロイド系抗炎症薬(NSAIDs)は、全消化管に高頻度に糜爛や潰瘍などの粘膜傷害を惹起する。NSAIDsは、cyclooxygenaseを阻害して粘膜のprostaglandin量を低下させるとともに、topical effectと呼ばれるミトコンドリアを標的とする上皮細胞傷害を起こし、消化管粘膜のバリアー機能を破綻させる。その結果、胃では胃酸、小腸では腸内細菌などの傷害因子が粘膜内に浸潤して炎症反応が誘導され、組織傷害が発症する。NSAIDs起因性上部消化管傷害に対しては、プロトンポンプ阻害薬などの強力な胃酸分泌抑制薬が開発された結果コントロールが比較的容易になった。一方、下部消化管傷害に対しては一部の薬剤の有効が報告されているが、エビデンスは十分ではなく、有効な予防・治療法の活立が急務である。(著者抄録)

  • 我々の論文「早期胃癌に対して内視鏡的粘膜下層剥離術を施行した患者におけるHelicobacter pylori除菌後の長期胃内菌共生バランス失調」に対するOuyangらのレターに対する返信(Reply to the letter by Ouyang et al. regarding our manuscript "Long-term persistence of gastric dysbiosis after eradication of Helicobacter pylori in patients who underwent endoscopic submucosal dissection for early gastric cancer") Reviewed

    Watanabe Toshio, Nadatani Yuji, Fujiwara Yasuhiro

    Gastric Cancer   24 ( 4 )   980 - 981   2021.07( ISSN:1436-3291

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  • 【酸分泌抑制薬の功罪】小腸・大腸 PPI投与とアスピリン小腸傷害 Reviewed

    渡邉 俊雄, 東森 啓, 灘谷 祐二, 大谷 恒史, 藤原 靖弘

    (株)東京医学社 消化器内視鏡   32 ( 8 )   1191 - 1195   2020.08( ISSN:0915-3217

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    カプセル内視鏡を用いた検討により、低用量アスピリン(LDA)が高頻度に小腸傷害を惹起することが明らかになった。LDAを含む非ステロイド性抗炎症薬(NSAIDs)による小腸傷害の機序には、腸内細菌が関与すると想定されている。一方、最近のげっ歯類を用いた検討により、プロトンポンプ阻害薬(PPI)が小腸細菌叢のdysbiosisを惹起し、NSAIDs起因性小腸傷害を増悪させる可能性が示唆されている。実際、PPIの併用によりNSAIDsあるいはLDAによる小腸傷害が増悪したとの臨床研究の結果が複数報告されているが、両者併用の小腸病変に及ぼす影響についてはいまだ結論が得られていない。両者併用の臨床的意義を評価するためには、PPIが出血性潰瘍や狭窄など臨床的重要度の高い小腸病変を増加させるか否かを検討する必要がある。(著者抄録)

  • 【消化器疾患と免疫系】薬剤起因性小腸傷害の基礎ならびに臨床研究 Reviewed

    渡邉 俊雄, 灘谷 祐二, 大谷 恒史, 谷川 徹也, 藤原 靖弘

    (有)科学評論社 臨床免疫・アレルギー科   74 ( 1 )   22 - 29   2020.07( ISSN:1881-1930

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  • 【薬剤性消化器疾患の診療】薬剤性消化器疾患のメカニズム 下部消化管(小腸・大腸) Reviewed

    渡邉 俊雄, 灘谷 祐二, 大谷 恒史, 谷川 徹也, 藤原 靖弘

    (株)日本メディカルセンター 臨床消化器内科   35 ( 7 )   683 - 688   2020.06( ISSN:0911-601X

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    <文献概要>非ステロイド性抗炎症薬(NSAID)は粘膜のプロスタグランジン量の低下作用に加えて,topical effectと呼ばれる上皮細胞に対する直接傷害作用により,粘膜バリア機能を破綻させる.その結果,腸内細菌などが粘膜内に浸潤して自然免疫系が活性化され,引き続き起こる好中球浸潤により小腸傷害が発症する.Toll-like receptor 4シグナルが炎症の起点となり,NLRP3インフラマソームなどが炎症ネットワークをさらに活性化する.また,フルオロウラシルやイリノテカンなどの殺細胞性抗がん剤による消化管傷害においてもこれらの自然免疫系が活性化され,傷害機序の中心的な役割を果たす.一方,vascular endothelialgrowth factor経路を標的とする分子標的治療薬は比較的高頻度に消化管穿孔を惹起するが,その機序には腸管虚血などの複数の要因が関与している可能性が示唆されている.

  • 【Helicobacter Year Book 2020-Helicobacter研究の進歩-】Helicobacter pylori除菌による胃がん抑制の新知見 Reviewed

    渡邉 俊雄, 藤原 靖弘

    (株)先端医学社 Helicobacter Research   24 ( 1 )   47 - 51   2020.05( ISSN:1342-4319

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    多くの臨床試験の結果、Helicobacter pylori除菌の胃がん予防効果については世界的にコンセンサスが得られつつある。しかし、高齢者や胃がん既往歴のある症例は胃粘膜の萎縮が高度で、腸上皮化生の合併例も多いため、これらの症例に対する除菌の効果については懐疑的な意見が存在する。2018年以降に、高齢者における除菌の胃がんの一次予防効果を示すコホート研究の結果、さらには早期胃がん内視鏡治療症例に対する除菌の二次予防効果を示す2つのランダム化比較試験の結果が報告され、ハイリスク症例に対しても除菌の有用性が明確に示された。一方、日常臨床では多くの除菌後胃がん症例を経験するが、除菌後胃がんのリスクをプロトンポンプ阻害薬などの一部の薬剤が修飾する可能性が報告された。(著者抄録)

  • 非ステロイド性抗炎症薬による小腸損傷に関する現在の知識 包括的レビュー(Current knowledge on non-steroidal anti-inflammatory drug-induced small-bowel damage: a comprehensive review) Reviewed

    Watanabe Toshio, Fujiwara Yasuhiro, Chan Francis K.L.

    シュプリンガー・ジャパン(株) Journal of Gastroenterology   55 ( 5 )   481 - 495   2020.05( ISSN:0944-1174

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  • 【薬剤性消化管障害の現況と展望】薬剤性消化管傷害のメカニズムの最新知見 Reviewed

    渡邉 俊雄, 藤原 靖弘

    (一財)日本消化器病学会 日本消化器病学会雑誌   116 ( 6 )   468 - 478   2019.06( ISSN:0446-6586

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    消化管傷害を惹起する代表的な薬剤は、非ステロイド性抗炎症薬(NSAIDs)である。NSAIDsは、粘膜のprostaglandin量を低下させるとともに、topical effectと呼ばれるミトコンドリアを標的とする上皮細胞傷害をおこし、粘膜のバリアー機能を破綻させる。その結果、炎症反応が誘導され、組織傷害が発症する。小腸では、グラム陰性菌によるToll-like receptor 4の活性化が炎症の起点となる。その他、抗がん剤、特に免疫チェックポイント阻害剤による大腸炎、microscopic colitis、スプルー様腸疾患などが注目されており、それぞれの発症機序の解明が望まれている。(著者抄録)

  • 【薬剤性消化管障害の現況と展望】薬剤性消化管傷害のメカニズムの最新知見 Reviewed

    渡邉 俊雄, 藤原 靖弘

    (一財)日本消化器病学会 日本消化器病学会雑誌   116 ( 6 )   468 - 478   2019.06( ISSN:0446-6586

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    消化管傷害を惹起する代表的な薬剤は、非ステロイド性抗炎症薬(NSAIDs)である。NSAIDsは、粘膜のprostaglandin量を低下させるとともに、topical effectと呼ばれるミトコンドリアを標的とする上皮細胞傷害をおこし、粘膜のバリアー機能を破綻させる。その結果、炎症反応が誘導され、組織傷害が発症する。小腸では、グラム陰性菌によるToll-like receptor 4の活性化が炎症の起点となる。その他、抗がん剤、特に免疫チェックポイント阻害剤による大腸炎、microscopic colitis、スプルー様腸疾患などが注目されており、それぞれの発症機序の解明が望まれている。(著者抄録)

  • 胆管ガイドワイヤ法を用いた小乳頭へのカニューレ挿入(Cannulation into the minor papilla using the bile duct guidewire method) Reviewed

    Maruyama Hirotsugu, Watanabe Toshio, Fujiwara Yasuhiro

    John Wiley & Sons Australia, Ltd Digestive Endoscopy   31 ( 2 )   e44 - e45   2019.03( ISSN:0915-5635

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  • 胆管ガイドワイヤ法を用いた小乳頭へのカニューレ挿入(Cannulation into the minor papilla using the bile duct guidewire method) Reviewed

    Maruyama Hirotsugu, Watanabe Toshio, Fujiwara Yasuhiro

    John Wiley & Sons Australia, Ltd Digestive Endoscopy   31 ( 2 )   e44 - e45   2019.03( ISSN:0915-5635

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  • 全国除菌レジストリー観察研究から発信できる成果・科学的視点 Invited

    渡辺俊雄、藤原靖弘

    Helicobacter Research   2018.02

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  • NSAIDs起因性小腸傷害の病態とプロバイオティクスの活用 Invited

    渡辺俊雄、谷川徹也、灘谷祐二、大谷恒史、藤原靖弘

    薬局   2017.09

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  • 腸内細菌とNSAIDs Invited

    渡辺俊雄, 東森啓, 灘谷祐二, 大谷恒史, 谷川徹也, 藤原靖弘

    PROGRESS IN MEDICINE   2017.06

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Presentations

  • 健診受診者における安静時体温の分布とその影響因子に関する研究 Domestic conference

    灘谷 祐二, 高嶋 信吾, 金森 厚志, 田内 幸枝, 中野 朱美, 打田 佐和子, 木村 達郎, 福本 真也, 中村 淳, 渡邉 俊雄

    人間ドック  2023.08  (公社)日本人間ドック学会

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  • COVID-19の大流行が及ぼす当院の肺がん検診への影響 Domestic conference

    木村 達郎, 福本 真也, 打田 佐和子, 中野 朱美, 灘谷 祐二, 田内 幸枝, 高嶋 信吾, 金森 厚志, 揚塩 直美, 渡邉 俊雄

    人間ドック  2023.08  (公社)日本人間ドック学会

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  • 消化管細菌叢と胃の疾患 胃神経内分泌腫瘍の発症と関連した、A型胃炎における胃粘膜関連細菌叢の変化について Domestic conference

    大谷 恒史, 渡邉 俊雄, 灘谷 祐二, 東森 啓, 田中 史生, 藤原 靖弘

    日本ヘリコバクター学会学術集会プログラム・抄録集  2023.06  (一社)日本ヘリコバクター学会

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  • 我が国の便通異常の実態と腸内細菌叢異常からみた病態 Domestic conference

    榎本 信幸, 渡邉 俊雄

    ENDOSCOPIC FORUM for digestive disease  2022.12  (株)癌と化学療法社

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  • 人間ドック受診者におけるアミノインデックス(胃)と既知の胃がんリスクとの関連について Domestic conference

    高嶋 信吾, 灘谷 祐二, 西居 由布子, 田内 幸枝, 藤井 英樹, 中野 朱美, 木村 達郎, 福本 真也, 藤原 靖弘, 渡邉 俊雄

    人間ドック  2022.08  (公社)日本人間ドック学会

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  • 機能性便秘と過敏性腸症候群におけるヘリコバクター・ピロリ感染状態と上部消化管内視鏡所見について Domestic conference

    大谷 恒史, 渡邉 俊雄, 灘谷 祐二, 東森 啓, 田中 史生, 藤原 靖弘

    日本ヘリコバクター学会学術集会プログラム・抄録集  2022.06  (一社)日本ヘリコバクター学会

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  • ディスペプシアと消化管細菌叢 ストレス負荷マウスの腸管バリアに対するプロトンポンプ阻害剤の影響について Domestic conference

    高嶋 信吾, 灘谷 祐二, 東森 啓, 大谷 恒史, 田中 史生, 渡邉 俊雄, 藤原 靖弘

    日本ヘリコバクター学会学術集会プログラム・抄録集  2022.06  (一社)日本ヘリコバクター学会

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  • 除菌後胃癌と胃細菌叢異常との関連 Domestic conference

    渡邉 俊雄

    日本胃癌学会総会記事  2022.03  (一社)日本胃癌学会

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  • 薬剤性およびアレルギー性消化管疾患の病態と診療 健診を契機に発見された好酸球性食道炎の特徴 Domestic conference

    高嶋 信吾, 灘谷 祐二, 渡邉 俊雄

    日本消化器病学会雑誌  2022.03  (一財)日本消化器病学会

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  • 脂肪肝炎:今後の展開 脂肪肝の各サブタイプにおける臨床背景ならびに生活習慣の差異 Domestic conference

    藤井 英樹, 灘谷 祐二, 渡邉 俊雄

    日本消化器病学会雑誌  2022.03  (一財)日本消化器病学会

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  • NAFLDからMAFLDへ-脂肪性肝疾患の新たなコンセプト形成に向けて FAST-scoreを用いた健診受診者におけるMAFLD・NAFLDの重症度予測 Domestic conference

    藤井 英樹, 渡邉 俊雄, 河田 則文

    肝臓  2021.11  (一社)日本肝臓学会

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  • 便秘患者の腸管洗浄における1-L PEG-Ascとリナクロチドまたはセンノシドの併用に関する比較検討(Comparison of 1-L PEG-Asc with linaclotide versus sennoside for colon cleaning in constipated patients) Domestic conference

    Maeda Natsumi, Nakatani Masami, Higashimori Akira, Jinnai Kagami, Kin Daiyu, Nakamura Yoshihiro, Morimoto Kenichi, Sasaki Eiji, Fukuda Takashi, Watanabe Toshio, Fujiwara Yasuhiro

    日本消化器病学会雑誌  2021.10  (一財)日本消化器病学会

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  • 便秘患者における腸洗浄のためのlinaclotideとsennosideを含む1-L PEG-Ascの比較検討(Comparison of 1-L PEG-Asc with linaclotide versus sennoside for colon cleaning in constipated patients) Domestic conference

    Maeda Natsumi, Nakatani Masami, Higashimori Akira, Jinnai Kagami, Kin Daiyu, Nakamura Yoshihiro, Morimoto Kenichi, Sasaki Eiji, Fukuda Takashi, Watanabe Toshio, Fujiwara Yasuhiro

    日本消化器がん検診学会雑誌  2021.10  (一社)日本消化器がん検診学会

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  • 便秘患者における結腸洗浄のためのリナクロチドとセンノシドを含む1-LPEG-Ascの比較(Comparison of 1-L PEG-Asc with linaclotide versus sennoside for colon cleaning in constipated patients) Domestic conference

    Maeda Natsumi, Nakatani Masami, Higashimori Akira, Jinnai Kagami, Kin Daiyu, Nakamura Yoshihiro, Morimoto Kenichi, Sasaki Eiji, Fukuda Takashi, Watanabe Toshio, Fujiwara Yasuhiro

    Gastroenterological Endoscopy  2021.10  (一社)日本消化器内視鏡学会

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  • より安全なトリアムシノロン浸水下局注 食道ESD後狭窄予防 Domestic conference

    落合 正, 永見 康明, 河野 光泰, 眞鍋 琢, 田上 光治郎, 山村 匡史, 丸山 紘嗣, 大南 雅揮, 福永 周生, 灘谷 祐二, 大谷 恒史, 細見 周平, 田中 史生, 鎌田 紀子, 平良 高一, 渡邉 俊雄, 藤原 靖弘

    Gastroenterological Endoscopy  2021.10  (一社)日本消化器内視鏡学会

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  • 内視鏡による経時的評価しえた食道壁内血腫の2例 Domestic conference

    住田 真衣子, 落合 正, 大南 雅揮, 平野 慎二, 眞鍋 琢, 河野 光泰, 山村 匡史, 田上 光治郎, 丸山 紘嗣, 灘谷 祐二, 福永 周生, 大谷 恒史, 細見 周平, 田中 史生, 鎌田 紀子, 永見 康明, 平良 高一, 渡邉 俊雄, 藤原 靖弘

    日本消化器病学会近畿支部例会プログラム・抄録集  2021.09  日本消化器病学会-近畿支部

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  • 胸部単純X線検査における要精密検査判定の経年変化について Domestic conference

    木村 達郎, 福本 真也, 中野 朱美, 藤井 英樹, 灘谷 祐二, 田内 幸枝, 高嶋 信吾, 西居 由布子, 河田 則文, 渡邉 俊雄

    人間ドック  2021.08  (公社)日本人間ドック学会

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  • 肝線維化進展NAFLDの100%の拾い上げを目指した際の費用対効果の検討 Domestic conference

    藤井 英樹, 福本 真也, 木村 達郎, 中野 朱美, 灘谷 祐二, 田内 幸枝, 高嶋 信吾, 西居 由布子, 河田 則文, 渡邉 俊雄

    人間ドック  2021.08  (公社)日本人間ドック学会

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  • 大学病院附属健診施設MedCity21におけるCOVID-19感染対策の取り組み Domestic conference

    灘谷 祐二, 高嶋 信吾, 西居 由布子, 田内 幸枝, 藤井 英樹, 中野 朱美, 木村 達郎, 福本 真也, 渡邉 俊雄

    人間ドック  2021.08  (公社)日本人間ドック学会

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  • 人間ドックを契機に発見された好酸球性食道炎の臨床的特徴の検討 Domestic conference

    高嶋 信吾, 灘谷 祐二, 藤井 英樹, 西居 由布子, 田内 幸枝, 中野 朱美, 木村 達郎, 福本 真也, 藤原 靖弘, 渡邉 俊雄

    人間ドック  2021.08  (公社)日本人間ドック学会

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  • 出血性過形成性ポリープ様形態を呈し、内視鏡的粘膜切除術により完全切除および診断し得た淡明細胞型腎細胞癌胃転移の一例 Domestic conference

    田島 光, 眞鍋 琢, 大谷 恒史, 田上 光治郎, 沢田 明也, 東森 啓, 西田 裕, 丸山 紘嗣, 大南 雅揮, 灘谷 祐二, 福永 周生, 細見 周平, 田中 史生, 鎌田 紀子, 永見 康明, 平良 高一, 渡邉 俊雄, 藤原 靖弘

    日本消化器内視鏡学会近畿支部例会プログラム・抄録集  2021.07  日本消化器内視鏡学会-近畿支部

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  • 胃粘膜下腫瘍様の形態を呈した早期胃癌の一例 Domestic conference

    竹下 雅浩, 田上 光治郎, 山本 圭以, 眞鍋 琢, 河野 光泰, 落合 正, 山村 匡史, 東森 啓, 丸山 紘嗣, 大南 雅揮, 灘谷 祐二, 福永 周生, 大谷 恒史, 細見 周平, 田中 史生, 鎌田 紀子, 永見 康明, 平良 高一, 渡邉 俊雄, 藤原 靖弘

    日本消化器内視鏡学会近畿支部例会プログラム・抄録集  2021.07  日本消化器内視鏡学会-近畿支部

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  • 食道ESD後狭窄予防におけるトリアムシノロンの浸水下局注法 Domestic conference

    落合 正, 永見 康明, 藤原 靖弘, 平良 高一, 渡邉 俊雄

    Gastroenterological Endoscopy  2021.04  (一社)日本消化器内視鏡学会

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  • 超高齢者における早期胃癌に対するESDの妥当性 Domestic conference

    大南 雅揮, 永見 康明, 藤原 靖弘, 山本 圭以, 平野 慎二, 河野 光泰, 眞鍋 琢, 落合 正, 垣谷 有紀, 山村 匡史, 田上 光治郎, 丸山 紘嗣, 灘谷 祐二, 福永 周生, 大谷 恒史, 細見 周平, 田中 史生, 鎌田 紀子, 平良 高一, 渡邉 俊雄

    Gastroenterological Endoscopy  2021.04  (一社)日本消化器内視鏡学会

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  • 悪性胆道狭窄の胆汁粘度とその後の胆道ステントの再閉塞の検討 Domestic conference

    山本 圭以, 丸山 紘嗣, 藤原 靖弘, 眞鍋 琢, 河野 光泰, 落合 正, 垣谷 有紀, 中田 晃暢, 山村 匡史, 田上 光治郎, 東森 啓, 大南 雅揮, 灘谷 祐二, 福永 周生, 大谷 恒史, 細見 周平, 田中 史生, 鎌田 紀子, 永見 康明, 平良 高一, 渡邉 俊雄

    Gastroenterological Endoscopy  2021.04  (一社)日本消化器内視鏡学会

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  • ESDで切除したsessile serrated adenoma/polyp(SSA/P)由来の早期大腸癌の検討 Domestic conference

    原田 優介, 河野 光泰, 福永 周生, 田上 光治郎, 丸山 紘嗣, 大南 雅揮, 灘谷 祐二, 大谷 恒史, 細見 周平, 田中 史生, 鎌田 紀子, 永見 康明, 平良 高一, 渡邉 俊雄, 藤原 靖弘

    日本消化管学会雑誌  2021.01  (一社)日本消化管学会

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  • 高脂肪食によるディスバイオシスは、インターロイキン17Aの中和によって改善した非ステロイド性抗炎症薬起因性小腸傷害を増悪させる(High-fat diet-mediated dysbiosis increases susceptibility to NSAID-induced small intestinal damage that is rescued by IL-17A neutralization) Domestic conference

    Sugimura Naoki, Otani Koji, Watanabe Toshio, Nakatsu Geicho, Shimada Sunao, Fujimoto Kosuke, Nadatani Yuji, Hosomi Shuhei, Tanaka Fumio, Kamata Noriko, Taira Koichi, Nagami Yasuaki, Tanigawa Tetsuya, Uematsu Satoshi, Fujiwara Yasuhiro

    日本消化管学会雑誌  2021.01  (一社)日本消化管学会

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  • 食道扁平上皮癌患者に対する食道ESD後は重篤な併存疾患によって予後が悪化する(Severe comorbidities influenced poor prognosis after endoscopic submucosal dissection for esophageal squamous cell carcinoma) Domestic conference

    平野 慎二, 永見 康明, 坂井 大志, 河野 光泰, 眞鍋 琢, 落合 正, 山村 匡史, 田上 光治郎, 丸山 紘嗣, 大南 雅揮, 灘谷 祐二, 福永 周生, 大谷 恒史, 細見 周平, 田中 史生, 鎌田 紀子, 平良 高一, 渡邉 俊雄, 藤原 靖弘

    日本消化管学会雑誌  2021.01  (一社)日本消化管学会

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  • 通院化学療法中の消化管癌患者に対するCOVID-19流行の影響 Domestic conference

    平良 高一, 岩見 明子, 平良 瑞姫, 木村 明恵, 中田 晃暢, 田中 浩明, 李 栄柱, 六車 一哉, 井関 康仁, 福岡 達成, 渋谷 雅常, 永原 央, 大平 雅一, 永見 康明, 渡邉 俊雄, 藤原 靖弘

    日本消化管学会雑誌  2021.01  (一社)日本消化管学会

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  • 胃内視鏡検診をふまえた経鼻内視鏡の新展開 コロナ流行期における上部消化管内視鏡検査のニューノーマル 経鼻内視鏡とマスクを用いた簡便な感染予防策 Domestic conference

    東森 啓, 灘谷 祐二, 高嶋 信吾, 丸山 紘嗣, 福永 周生, 大谷 恒史, 細見 周平, 田中 史生, 永見 康明, 平良 高一, 渡邉 俊雄, 藤原 靖弘

    日本消化管学会雑誌  2021.01  (一社)日本消化管学会

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  • 消化管疾患とマイクロバイオームのクロストーク 胃がん高リスク患者におけるH. pylori除菌前後の変化に注目した胃細菌叢についての検討 Domestic conference

    灘谷 祐二, 渡邉 俊雄, 大谷 恒史, 東森 啓, 藤原 靖弘

    日本消化管学会雑誌  2021.01  (一社)日本消化管学会

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  • 消化管内視鏡診療とCOVID-19 多施設アンケート Domestic conference

    丸山 紘嗣, 細見 周平, 根引 浩子, 福田 隆, 仲川 浩一郎, 岡崎 博俊, 山上 博一, 原 順一, 谷川 徹也, 町田 浩久, 青松 和輝, 渡邊 芳久, 佐藤 博之, 宇野 裕典, 高石 修, 野村 勉, 越智 正博, 押谷 伸英, 足立 賢治, 東森 啓, 大南 雅揮, 灘谷 祐二, 福永 周生, 大谷 恒史, 田中 史生, 鎌田 紀子, 氷見 康明, 平良 高一, 渡邉 俊雄, 藤原 靖弘

    日本消化管学会雑誌  2021.01  (一社)日本消化管学会

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  • 消化管におけるtranslational research 非ステロイド性抗炎症薬起因性重症小腸傷害に対するコルヒチン治療の有効性についてのパイロット試験 Domestic conference

    大谷 恒史, 渡邉 俊雄, 東森 啓, 灘谷 祐二, 藤原 靖弘

    日本消化管学会雑誌  2021.01  (一社)日本消化管学会

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  • 当院における切除不能再発胃癌に対するnivolumabの使用経験 Domestic conference

    木村 明恵, 平良 高一, 中田 晃暢, 田上 光治郎, 東森 啓, 鋳谷 成弘, 西田 裕, 丸山 紘嗣, 大南 雅揮, 大谷 恒史, 灘谷 祐二, 福永 周生, 細見 周平, 田中 史生, 鎌田 紀子, 永見 康明, 渡邉 俊雄, 藤原 靖弘

    日本消化管学会雑誌  2021.01  (一社)日本消化管学会

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  • 十二指腸uncovered metallic stent留置後の腫瘍出血に対してcovered metallic stentが止血に有効であった一例 Domestic conference

    高橋 駿介, 山村 匡史, 丸山 紘嗣, 山本 圭以, 眞鍋 琢, 河野 光泰, 落合 正, 垣谷 有紀, 田上 光治郎, 東森 啓, 大南 雅揮, 福永 周生, 大谷 恒史, 細見 周平, 田中 史生, 鎌田 紀子, 永見 康明, 平良 高一, 渡邉 俊雄, 藤原 靖弘

    日本消化管学会雑誌  2021.01  (一社)日本消化管学会

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  • 内視鏡的活動性を指標としたアダリムマブ増量はクローン病治療戦略として有用か? Domestic conference

    細見 周平, 藤本 晃士, 中田 理恵子, 西田 裕, 鋳谷 成弘, 福永 周生, 灘谷 祐二, 大谷 恒史, 田中 史生, 鎌田 紀子, 永見 康明, 平良 高一, 渡邉 俊雄, 藤原 靖弘

    日本消化管学会雑誌  2021.01  (一社)日本消化管学会

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  • インドメタシン誘発小腸障害に対するレバミピドの阻害効果とプロトンポンプ阻害剤による傷害の悪化における、小腸細菌叢の重要性(The Significance of Small Intestinal Microbiota in the Inhibitory Effect of Rebamipide against Indomethacin-induced Small Intestinal Damage and Exacerbation of the Damage by Proton Pump Inhibitor) Domestic conference

    Tanigawa Tetsuya, Watanabe Toshio, Higashimori Akira, Shimada Sunao, Kitamura Hiroyuki, Kuzumoto Takuya, Nadatani Yuji, Otani Koji, Fukunaga Shusei, Hosomi Shuhei, Tanaka Fumio, Kamata Noriko, Nagami Yasuaki, Taira Koichi, Shiba Masatsugu, Suda Wataru, Hattori Masahira, Fujiwara Yasuhiro

    日本消化管学会雑誌  2021.01  (一社)日本消化管学会

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  • より安全で確実な十二指腸ESDを行うための工夫 Domestic conference

    河野 光泰, 永見 康明, 眞鍋 琢, 落合 正, 山村 匡史, 大南 雅揮, 灘谷 祐二, 福永 周生, 大谷 恒史, 細見 周平, 田中 史生, 平良 高一, 渡邉 俊雄, 藤原 靖弘, 木村 健二郎

    日本消化管学会雑誌  2021.01  (一社)日本消化管学会

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  • Nivolumab長期加療中に斜台転移を認めた進行胃癌の一例 Domestic conference

    中田 晃暢, 木村 明恵, 平良 高一, 田上 光治郎, 東森 啓, 西田 裕, 鋳谷 成弘, 丸山 紘嗣, 大南 雅揮, 福永 周生, 灘谷 祐二, 大谷 恒史, 細見 周平, 田中 史生, 永見 康明, 鎌田 紀子, 渡邉 俊雄, 藤原 靖弘

    日本消化管学会雑誌  2021.01  (一社)日本消化管学会

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  • Nivolumab長期加療中に斜台転移を認めた進行胃癌の一例 Domestic conference

    中田 晃暢, 木村 明恵, 平良 高一, 田上 光治郎, 東森 啓, 西田 裕, 鋳谷 成弘, 丸山 紘嗣, 大南 雅揮, 福永 周生, 灘谷 祐二, 大谷 恒史, 細見 周平, 田中 史生, 永見 康明, 鎌田 紀子, 渡邉 俊雄, 藤原 靖弘

    日本消化管学会雑誌  2021.01  (一社)日本消化管学会

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  • 高脂肪食によるディスバイオシスは、インターロイキン17Aの中和によって改善した非ステロイド性抗炎症薬起因性小腸傷害を増悪させる(High-fat diet-mediated dysbiosis increases susceptibility to NSAID-induced small intestinal damage that is rescued by IL-17A neutralization) Domestic conference

    Sugimura Naoki, Otani Koji, Watanabe Toshio, Nakatsu Geicho, Shimada Sunao, Fujimoto Kosuke, Nadatani Yuji, Hosomi Shuhei, Tanaka Fumio, Kamata Noriko, Taira Koichi, Nagami Yasuaki, Tanigawa Tetsuya, Uematsu Satoshi, Fujiwara Yasuhiro

    日本消化管学会雑誌  2021.01  (一社)日本消化管学会

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  • 通院化学療法中の消化管癌患者に対するCOVID-19流行の影響 Domestic conference

    平良 高一, 岩見 明子, 平良 瑞姫, 木村 明恵, 中田 晃暢, 田中 浩明, 李 栄柱, 六車 一哉, 井関 康仁, 福岡 達成, 渋谷 雅常, 永原 央, 大平 雅一, 永見 康明, 渡邉 俊雄, 藤原 靖弘

    日本消化管学会雑誌  2021.01  (一社)日本消化管学会

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  • 胃内視鏡検診をふまえた経鼻内視鏡の新展開 コロナ流行期における上部消化管内視鏡検査のニューノーマル 経鼻内視鏡とマスクを用いた簡便な感染予防策 Domestic conference

    東森 啓, 灘谷 祐二, 高嶋 信吾, 丸山 紘嗣, 福永 周生, 大谷 恒史, 細見 周平, 田中 史生, 永見 康明, 平良 高一, 渡邉 俊雄, 藤原 靖弘

    日本消化管学会雑誌  2021.01  (一社)日本消化管学会

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  • 消化管疾患とマイクロバイオームのクロストーク 胃がん高リスク患者におけるH. pylori除菌前後の変化に注目した胃細菌叢についての検討 Domestic conference

    灘谷 祐二, 渡邉 俊雄, 大谷 恒史, 東森 啓, 藤原 靖弘

    日本消化管学会雑誌  2021.01  (一社)日本消化管学会

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  • 消化管内視鏡診療とCOVID-19 多施設アンケート Domestic conference

    丸山 紘嗣, 細見 周平, 根引 浩子, 福田 隆, 仲川 浩一郎, 岡崎 博俊, 山上 博一, 原 順一, 谷川 徹也, 町田 浩久, 青松 和輝, 渡邊 芳久, 佐藤 博之, 宇野 裕典, 高石 修, 野村 勉, 越智 正博, 押谷 伸英, 足立 賢治, 東森 啓, 大南 雅揮, 灘谷 祐二, 福永 周生, 大谷 恒史, 田中 史生, 鎌田 紀子, 氷見 康明, 平良 高一, 渡邉 俊雄, 藤原 靖弘

    日本消化管学会雑誌  2021.01  (一社)日本消化管学会

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  • 消化管におけるtranslational research 非ステロイド性抗炎症薬起因性重症小腸傷害に対するコルヒチン治療の有効性についてのパイロット試験 Domestic conference

    大谷 恒史, 渡邉 俊雄, 東森 啓, 灘谷 祐二, 藤原 靖弘

    日本消化管学会雑誌  2021.01  (一社)日本消化管学会

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  • 当院における切除不能再発胃癌に対するnivolumabの使用経験 Domestic conference

    木村 明恵, 平良 高一, 中田 晃暢, 田上 光治郎, 東森 啓, 鋳谷 成弘, 西田 裕, 丸山 紘嗣, 大南 雅揮, 大谷 恒史, 灘谷 祐二, 福永 周生, 細見 周平, 田中 史生, 鎌田 紀子, 永見 康明, 渡邉 俊雄, 藤原 靖弘

    日本消化管学会雑誌  2021.01  (一社)日本消化管学会

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  • 十二指腸uncovered metallic stent留置後の腫瘍出血に対してcovered metallic stentが止血に有効であった一例 Domestic conference

    高橋 駿介, 山村 匡史, 丸山 紘嗣, 山本 圭以, 眞鍋 琢, 河野 光泰, 落合 正, 垣谷 有紀, 田上 光治郎, 東森 啓, 大南 雅揮, 福永 周生, 大谷 恒史, 細見 周平, 田中 史生, 鎌田 紀子, 永見 康明, 平良 高一, 渡邉 俊雄, 藤原 靖弘

    日本消化管学会雑誌  2021.01  (一社)日本消化管学会

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  • 内視鏡的活動性を指標としたアダリムマブ増量はクローン病治療戦略として有用か? Domestic conference

    細見 周平, 藤本 晃士, 中田 理恵子, 西田 裕, 鋳谷 成弘, 福永 周生, 灘谷 祐二, 大谷 恒史, 田中 史生, 鎌田 紀子, 永見 康明, 平良 高一, 渡邉 俊雄, 藤原 靖弘

    日本消化管学会雑誌  2021.01  (一社)日本消化管学会

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  • ESDで切除したsessile serrated adenoma/polyp(SSA/P)由来の早期大腸癌の検討 Domestic conference

    原田 優介, 河野 光泰, 福永 周生, 田上 光治郎, 丸山 紘嗣, 大南 雅揮, 灘谷 祐二, 大谷 恒史, 細見 周平, 田中 史生, 鎌田 紀子, 永見 康明, 平良 高一, 渡邉 俊雄, 藤原 靖弘

    日本消化管学会雑誌  2021.01  (一社)日本消化管学会

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  • インドメタシン誘発小腸障害に対するレバミピドの阻害効果とプロトンポンプ阻害剤による傷害の悪化における、小腸細菌叢の重要性(The Significance of Small Intestinal Microbiota in the Inhibitory Effect of Rebamipide against Indomethacin-induced Small Intestinal Damage and Exacerbation of the Damage by Proton Pump Inhibitor) Domestic conference

    Tanigawa Tetsuya, Watanabe Toshio, Higashimori Akira, Shimada Sunao, Kitamura Hiroyuki, Kuzumoto Takuya, Nadatani Yuji, Otani Koji, Fukunaga Shusei, Hosomi Shuhei, Tanaka Fumio, Kamata Noriko, Nagami Yasuaki, Taira Koichi, Shiba Masatsugu, Suda Wataru, Hattori Masahira, Fujiwara Yasuhiro

    日本消化管学会雑誌  2021.01  (一社)日本消化管学会

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  • より安全で確実な十二指腸ESDを行うための工夫 Domestic conference

    河野 光泰, 永見 康明, 眞鍋 琢, 落合 正, 山村 匡史, 大南 雅揮, 灘谷 祐二, 福永 周生, 大谷 恒史, 細見 周平, 田中 史生, 平良 高一, 渡邉 俊雄, 藤原 靖弘, 木村 健二郎

    日本消化管学会雑誌  2021.01  (一社)日本消化管学会

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  • 胆管静脈瘤出血に対してfull covered金属ステントを留置し止血に成功した一例 Domestic conference

    高嶋 遼太, 山本 圭以, 丸山 紘嗣, 落合 正, 中田 晃暢, 垣谷 有紀, 山村 匡史, 田上 光治郎, 東森 啓, 大南 雅揮, 灘谷 祐二, 福永 周生, 大谷 恒史, 細見 周平, 田中 史生, 鎌田 紀子, 永見 康明, 平良 高一, 渡邉 俊雄, 藤原 靖弘

    日本消化器内視鏡学会近畿支部例会プログラム・抄録集  2020.12  日本消化器内視鏡学会-近畿支部

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  • 放射線性食道炎におけるinterferon-αの役割 Domestic conference

    北村 寛之, 谷川 徹也, 灘谷 祐二, 大谷 恒史, 細見 周平, 田中 史生, 平良 高一, 永見 康明, 渡邉 俊雄, 藤原 靖弘

    日本食道学会学術集会プログラム・抄録集  2020.12  (NPO)日本食道学会

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  • 胆管静脈瘤出血に対してfull covered金属ステントを留置し止血に成功した一例 Domestic conference

    高嶋 遼太, 山本 圭以, 丸山 紘嗣, 落合 正, 中田 晃暢, 垣谷 有紀, 山村 匡史, 田上 光治郎, 東森 啓, 大南 雅揮, 灘谷 祐二, 福永 周生, 大谷 恒史, 細見 周平, 田中 史生, 鎌田 紀子, 永見 康明, 平良 高一, 渡邉 俊雄, 藤原 靖弘

    日本消化器内視鏡学会近畿支部例会プログラム・抄録集  2020.12  日本消化器内視鏡学会-近畿支部

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  • Nivolumab加療中に斜台転移を認めた進行胃癌の1例 Domestic conference

    片之坂 友喜, 木村 明恵, 平良 高一, 大谷 恒史, 灘谷 祐二, 福永 周生, 細見 周平, 田中 史生, 鎌田 紀子, 永見 康明, 渡邉 俊雄, 藤原 靖弘

    日本消化器病学会近畿支部例会プログラム・抄録集  2020.10  日本消化器病学会-近畿支部

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  • Nivolumab加療中に斜台転移を認めた進行胃癌の1例 Domestic conference

    片之坂 友喜, 木村 明恵, 平良 高一, 大谷 恒史, 灘谷 祐二, 福永 周生, 細見 周平, 田中 史生, 鎌田 紀子, 永見 康明, 渡邉 俊雄, 藤原 靖弘

    日本消化器病学会近畿支部例会プログラム・抄録集  2020.10  日本消化器病学会-近畿支部

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  • ブタモデルを用いた内視鏡的粘膜下層剥離術後の食道狭窄モデルに対するピルフェニドンの効果(The effect of Pirfenidone for esophageal stricture after endoscopic submucosal dissection in a porcine model) Domestic conference

    Hirano Shinji, Nagami Yasuaki, Sakai Taishi, Kakiya Yuki, Tanoue Kojirou, Hayashi Kappei, Yamamura Masafumi, Sawada Akinari, Maruyama Hirotsugu, Ominami Masaki, Fukunaga Shusei, Nadatani Yuji, Otani Koji, Hosomi Shuhei, Tanaka Fumio, Kamata Noriko, Noriko Koichi, Tanigawa Tetsuya, Watanabe Toshio, Fujiwara Yasuhiro

    Gastroenterological Endoscopy  2020.08  (一社)日本消化器内視鏡学会

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  • ブタモデルを用いた内視鏡的粘膜下層剥離術後の食道狭窄モデルに対するピルフェニドンの効果(The effect of Pirfenidone for esophageal stricture after endoscopic submucosal dissection in a porcine model) Domestic conference

    Hirano Shinji, Nagami Yasuaki, Sakai Taishi, Kakiya Yuki, Tanoue Kojirou, Hayashi Kappei, Yamamura Masafumi, Sawada Akinari, Maruyama Hirotsugu, Ominami Masaki, Fukunaga Shusei, Nadatani Yuji, Otani Koji, Hosomi Shuhei, Tanaka Fumio, Kamata Noriko, Noriko Koichi, Tanigawa Tetsuya, Watanabe Toshio, Fujiwara Yasuhiro

    Gastroenterological Endoscopy  2020.08  (一社)日本消化器内視鏡学会

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  • IgG4関連硬化性胆管炎に胆管癌を合併した一例 Domestic conference

    上村 拓也, 林 克平, 垣谷 有紀, 山村 匡史, 田上 光治郎, 西田 裕, 鋳谷 成弘, 丸山 紘嗣, 大南 雅揮, 福永 周生, 灘谷 祐二, 大谷 恒史, 細見 周平, 田中 史生, 鎌田 紀子, 平良 高一, 永見 康明, 谷川 徹也, 渡邉 俊雄, 藤原 靖弘

    日本消化器内視鏡学会近畿支部例会プログラム・抄録集  2020.06  日本消化器内視鏡学会-近畿支部

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  • IgG4関連硬化性胆管炎に胆管癌を合併した一例 Domestic conference

    上村 拓也, 林 克平, 垣谷 有紀, 山村 匡史, 田上 光治郎, 西田 裕, 鋳谷 成弘, 丸山 紘嗣, 大南 雅揮, 福永 周生, 灘谷 祐二, 大谷 恒史, 細見 周平, 田中 史生, 鎌田 紀子, 平良 高一, 永見 康明, 谷川 徹也, 渡邉 俊雄, 藤原 靖弘

    日本消化器内視鏡学会近畿支部例会プログラム・抄録集  2020.06  日本消化器内視鏡学会-近畿支部

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  • 胃の細菌叢に対するH.pylori除去の影響(Effect of eradication of H. pylori in gastric microbiome) Domestic conference

    Kosaka Satoshi, Nadatani Yuji, Watanabe Toshio, Suda Wataru, Nakata Akinobu, Matsumoto Yuji, Higashimori Akira, Otani Koji, Hosomi Shuhei, Tanaka Fumio, Nagami Yasuaki, Kamata Noriko, Taira Koichi, Tanigawa Tetsuya, Hattori Masahira, Fujiwara Yasuhiro

    日本消化管学会雑誌  2020.01  (一社)日本消化管学会

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  • 薬剤による消化管傷害の病態研究の進歩と最近の疾患の傾向と対策 非ステロイド系抗炎症薬誘発小腸傷害における抗炎症性脂質メディエーター レゾルビンD1の意義 Domestic conference

    葛本 琢哉, 谷川 徹也, 北村 寛之, 灘谷 祐二, 大谷 恒史, 細見 周平, 田中 史生, 鎌田 紀子, 平良 高一, 永見 康明, 渡邉 俊雄, 藤原 靖弘

    日本消化管学会雑誌  2020.01  (一社)日本消化管学会

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  • 胃の細菌叢に対するH.pylori除去の影響(Effect of eradication of H. pylori in gastric microbiome) Domestic conference

    Kosaka Satoshi, Nadatani Yuji, Watanabe Toshio, Suda Wataru, Nakata Akinobu, Matsumoto Yuji, Higashimori Akira, Otani Koji, Hosomi Shuhei, Tanaka Fumio, Nagami Yasuaki, Kamata Noriko, Taira Koichi, Tanigawa Tetsuya, Hattori Masahira, Fujiwara Yasuhiro

    日本消化管学会雑誌  2020.01  (一社)日本消化管学会

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  • 薬剤による消化管傷害の病態研究の進歩と最近の疾患の傾向と対策 非ステロイド系抗炎症薬誘発小腸傷害における抗炎症性脂質メディエーター レゾルビンD1の意義 Domestic conference

    葛本 琢哉, 谷川 徹也, 北村 寛之, 灘谷 祐二, 大谷 恒史, 細見 周平, 田中 史生, 鎌田 紀子, 平良 高一, 永見 康明, 渡邉 俊雄, 藤原 靖弘

    日本消化管学会雑誌  2020.01  (一社)日本消化管学会

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  • PPI長期内服とSIBOとの関連 Domestic conference

    藤原 靖弘, 谷川 徹也, 渡邉 俊雄

    日本小腸学会学術集会プログラム・抄録集  2019.11  日本小腸学会

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  • 胃切除後Roux-enY再建における総胆管結石に対するEI-580BTの有用性の検討 Domestic conference

    林 克平, 丸山 紘嗣, 垣谷 有紀, 木下 陽亮, 山村 匡史, 坂井 大志, 大南 雅揮, 灘谷 祐二, 福永 周生, 大谷 恒史, 細見 周平, 田中 史生, 永見 康明, 鎌田 紀子, 平良 高一, 山上 博一, 谷川 徹也, 渡邉 俊雄, 藤原 靖広

    Gastroenterological Endoscopy  2019.10  (一社)日本消化器内視鏡学会

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  • Peutz-Jegehers syndromeに膵癌を発症した一例 Domestic conference

    三崎 絢子, 山村 匡史, 丸山 紘嗣, 垣谷 有紀, 田上 光治郎, 林 克平, 西田 裕, 鋳谷 成弘, 大南 雅揮, 福永 周生, 灘谷 祐二, 大谷 恒史, 細見 周平, 田中 史生, 鎌田 紀子, 平良 高一, 永見 康明, 谷川 徹也, 渡邉 俊雄, 藤原 靖弘

    日本消化器病学会近畿支部例会プログラム・抄録集  2019.10  日本消化器病学会-近畿支部

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  • 薬剤性消化管障害の内視鏡診断 Invited Domestic conference

    渡邉 俊雄

    第36回 日本消化器内視鏡学会近畿セミナー  2019.08 

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  • 薬剤性消化管障害の内視鏡診断 Domestic conference

    渡邉 俊雄

    第36回 日本消化器内視鏡学会近畿セミナー  2019.08 

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  • 好酸球性食道炎患者におけるアレルギー性共存症の診断のための検査セットであるView allergy 39の活用(Utility of View allergy 39 for the diagnosis of allergic comorbidities in patients with eosinophilic esophagitis) Domestic conference

    Nakata Akinobu, Tanaka Fumio, Takashima Shingo, Hashimoto Atsushi, Yamagami Hirokazu, Tanigawa Tetsuya, Watanabe Toshio, Fujiwara Yasuhiro

    日本食道学会学術集会プログラム・抄録集  2019.06  (NPO)日本食道学会

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  • 当院での肝門部領域胆管狭窄に対するInside Stentの有用性と安全性の検討 Domestic conference

    林 克平, 丸山 紘嗣, 藤原 靖弘, 渡邉 俊雄, 谷川 徹也, 山上 博一, 平良 高一, 鎌田 紀子, 永見 康明, 田中 史生, 細見 周平, 大谷 恒史, 福永 周生, 灘谷 祐二, 大南 雅揮, 坂井 大志, 木下 陽亮, 田上 光治郎, 山村 匡史, 垣谷 有紀, 平野 慎二

    Gastroenterological Endoscopy  2019.05  (一社)日本消化器内視鏡学会

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  • シンポジウム4胃癌撲滅を達成する胃癌検診体制のこれから:全国除菌レジストリーの目的および意義 Domestic conference

    渡辺俊雄, 半田修, 杉山敏郎, 鈴木秀和

    第15回日本消化管学会総会学術集会  2019.02 

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  • 以前のESD創痕に近接した食道癌に対する内視鏡的粘膜下層剥離術(Endoscopic submucosal dissection for esophageal cancer close to the previous ESD scar) Domestic conference

    Nagami Yasuaki, Ominami Masaki, Fukunaga Shusei, Sakai Taishi, Otani Koji, Hosomi Shuhei, Tanaka Fumio, Taira Koichi, Yamagami Hirokazu, Tanigawa Tetsuya, Shiba Masatsugu, Watanabe Toshio, Fujiwara Yasuhiro

    日本消化管学会雑誌  2019.02  (一社)日本消化管学会

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  • PPI反応性好酸球性食道炎における自覚症状、内視鏡像、組織所見の改善度についての検討 Domestic conference

    藤原 靖弘, 橋本 篤, 上村 理沙, 沢田 明也, 大谷 恒史, 田中 史生, 山上 博一, 谷川 徹也, 渡邉 俊雄

    日本消化管学会雑誌  2019.02  (一社)日本消化管学会

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  • 小腸出血性疾患診断と治療 Invited Domestic conference

    渡辺俊雄

    第34回日本消化器内視鏡学会近畿セミナー  2018.08 

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  • 薬剤性腸管傷害 Invited Domestic conference

    渡辺俊雄

    第104会日本消化器病学会総会  2018.04 

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  • 全国除菌レジストリーの目的・意義 Invited Domestic conference

    渡辺俊雄

    第1回 全国除菌レジストリー 近畿地区説明会・倫理講習会  2018.02 

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  • PPI治療 ~オンデマンドか?少量維持療法か?~ 少量維持療法を推奨する立場から Invited Domestic conference

    渡辺俊雄

    第14回日本消化管学会総会学術集会  2018.02 

  • 薬剤性小腸傷害とマイクロバイオーム Invited Domestic conference

    渡辺俊雄

    第21回腸内細菌学会  2017.06 

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    Presentation type:Symposium, workshop panel (nominated)  

  • ヘリコバクター・ピロリ感染の影響を含めたヒト胃細菌叢の検討 Domestic conference

    灘谷 祐二、渡辺 俊雄、大谷 恒史、谷川 徹也、藤原 靖弘

    第23回日本ヘリコバクター学会学術集会  2017.06 

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  • 166. Does discontinuation of antithrombotic agents affect diagnostic yield of small bowel capsule endoscopy in patients with obscure gastrointestinal bleeding International conference

    Watanabe T, Shimada S, Nadatani Y, Otani K, Tanaka F, Nagami Y, Kamata N, Yamagami H, Tanigawa T, Shiba M, Miyazaki T, Nakamura S, Fujiwara Y

    DDW2017  2017.05 

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  • Roles of innate immune system in mice small intestinal ischemia-reperfusion injury Domestic conference

    灘谷 祐二、渡辺俊雄、大谷恒史、谷川徹也、藤原靖弘,

    第42回日本微小循環学会総会シンポジウム  2017.03 

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  • Does discontinuation of antithrombotic agents affect diagnostic yield of small bowel capsule endoscopy in patients with obscure gastrointestinal bleeding? International conference

    Watanabe T, Shimada S, Nadatani Y, Otani K, Tanaka F, Nagami Y, Kamata N, Yamagami H, Tanigawa T, Shiba M, Miyazaki T, Nakamura S, Fujiwara Y

    The 118th Annual Meeting of the AGA (Chicago)   2017 

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  • カプセル内視鏡にて病変非検出OGIB症例に対する再検小腸内視鏡検査の有用性:ダブルバルーン内視鏡とカプセル内視鏡の比較 Domestic conference

    大谷恒史, 渡辺俊雄, 斯波将次, 島田直, 灘谷祐二, 細見周平, 永見康明, 田中史生, 鎌田紀子, 山上博一, 谷川徹也, 富永和作, 藤原靖弘

    第13回日本消化管学会総会学術集会  2017 

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  • 新規プロトンポンプ阻害薬ボノプラザン投与による小腸細菌叢の変化とNSAIDs起因性小腸傷害に対する影響の検討 Domestic conference

    灘谷 祐二、渡辺俊雄、藤原靖弘

    第103回日本消化器病学会総会  2017 

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  • カプセル内視鏡でも原因不明の消化管出血に対する,再検小腸内視鏡検査の意義について Domestic conference

    大谷 恒史,渡辺 俊雄,藤原 靖弘

    第103回日本消化器病学会総会  2017 

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  • 16S rRNA解析によるプロトンポンプ阻害薬投与後の小腸細菌叢の変化とNSAIDs起因性小腸傷害に与える影響の検討 Domestic conference

    谷 祐二, 渡辺俊雄, 杉村直毅, 島田直, 大谷恒史, 谷川徹也, 永見康明, 田中史生, 鎌田紀子, 斯波将次, 山上博一, 富永和作, 藤原靖弘

    第13回日本消化管学会総会学術集会  2017 

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  • 上部消化管内視鏡を用いた胃マイクロバイオームの検討ーH.pylori除菌による変化の検討を含めてー. Domestic conference

    灘谷 祐二、渡辺俊雄、藤原靖弘

    第93回日本消化器内視鏡学会総会  2017 

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  • NLRP3インフラマソーム活性化阻害剤としてのコルヒチン-NSAIDs起因性小腸傷害の治療薬としての可能性 Invited Domestic conference

    渡辺俊雄, 大谷恒史, 東森啓, 灘谷祐二, 谷川徹也, 富永和作, 藤原靖弘,  荒川哲男

    第44回日本潰瘍学会  2016.09 

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  • ヒト胃マイクロバイオームの検討―H. pylori 除菌による変化の検討を含めて Domestic conference

    灘谷 祐二, 渡辺 俊雄, 武田 翔伍, 島田 直, 大谷 恒史, 谷川 徹也, 永見 康明, 田中 史生, 鎌田 紀子, 斯波 将次, 山上 博一, 富永 和作, 藤原 靖弘

    第53回消化器免疫学会総会  2016.07 

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  • NSAID enteropathy: New aspects of pathophysiology Invited International conference

    Watanabe T

    The 1st International Meeting on Intestinal Diseases (Seoul)   2016.04 

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  • レバミピドは非ステロイド系抗炎症薬起因性小腸傷害に対して、傷害抑制的な小腸フローラを形成する Domestic conference

    大谷恒史, 谷川徹也, 渡辺俊雄, 武田翔伍, 東森啓, 島田直, 灘谷祐二, 永見康明, 田中史生, 鎌田紀子, 山上博一, 斯波将次, 富永和作, 藤原靖弘, 荒川哲

    第12回日本消化管学会総会  2016 

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  • 原因不明の消化管出血患者に対して施行したカプセル内視鏡検査での陽性所見検出率に関連する因子の検討;単独施設後ろ向き研究 Domestic conference

    島田 直, 渡辺 俊雄, 灘谷 祐二, 武田 翔伍, 大谷 恒史, 田中 史生, 永見 康明, 鎌田 紀子, 山上 博一, 谷川 徹也, 斯波 将次, 富永 和作, 藤原 靖弘, 荒川 哲男

    第12回日本消化管学会総会学術集会  2016 

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  • NSAID起因性小腸傷害の現状と対策 Invited Domestic conference

    大谷恒史, 渡辺俊雄, 藤原靖弘

    第26回日本リウマチ学会近畿支部学術集会  2016 

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  • Overt OGIB患者における抗血栓薬の中止がカプセル内視鏡での有病変率に及ぼす影響 Domestic conference

    島田直, 斯波将次, 渡辺俊雄

    第92回日本消化器内視鏡学会総会  2016 

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  • 胃がんリスクを考えるー内視鏡的胃炎診断を中心にー Invited Domestic conference

    渡辺俊雄

    第44会日本消化器がん検診学会近畿地方会  2015.08 

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  • MECHANISMS OF ACTIVATION OF THE NLRP3 INFLAMMASOME AND ITS ROLE IN NSAID-INDUCED SMALL INTESTINAL DAMAGE The 15th International International conference

    Watanabe T, Higashimori A, Nadatani Y, Tanigawa T, Tominaga K, Fujiwara Y, Arakaw T

    Conference on Ulcer Research(Otawa)   2015 

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  • 抗血栓薬内服中のOGIB症例の小腸病変の特徴と薬剤中止が病変検出に及ぼす影響 Invited Domestic conference

    島田直, 谷川徹也, 渡辺俊雄

    第89回日本消化器内視鏡学会総会  2015 

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  • レバミピドの小腸フローラ調節作用と非ステロイド系抗炎症薬起因性小腸傷害抑制作用およびプロトンポンプ阻害薬による本傷害の増悪に対する作用について Domestic conference

    谷川徹也, 武田翔伍, 渡辺俊雄

    第101回消化器病学会総会  2015 

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  • Non-steroidal anti-inflammatory drugs injure the small intestine through NLRP3 inflammasome activation International conference

    Watanabe T, Higashimori A, Nadatani Y, Tanigawa T, Tominaga K, Fujiwara Y, Arakawa T

    22nd United European Gastroenterology Week (Vienna)  2014.10 

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  • Prevention of Recurrence of Gastric and Duodenal Ulcers by Rabeprazole in Patients Taking Low-Dose Aspirin International conference

    Watanabe T, Higuchi K, Kato M, Fujishiro M, Kinoshita Y, Iwakiri R, Umegaki E, Sugisaki N, Okada Y, Ogawa H, Arakawa T, Fujimoto K.

    Digestive Disease Week 2014 (Chicago)  2014.05 

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  • Importance of TLR4-dependent pathways for the pathogenesis and treatment of NSAID-induced enteropathy Invited International conference

    Toshio Watanabe, Tetsuo Arakawa

    The 100th Annual Meeting of the Japanese Societ y of Gastroenterology, The 4th International Forum  2014.04 

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  • 胃潰瘍治癒過程におけるプロスタグランジン代謝酵素:15-hydroxyprostaglandin dehydrogenaseの発現動態とその調節因子について Domestic conference

    谷川 徹也, 渡辺 俊雄, 荒川 哲男

    第56回日本消化器病学会大会  2014 

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  • NSAIDsによる重症小腸傷害のリスクファクターについての臨床的検討 Domestic conference

    大谷恒史, 灘谷祐二, 渡辺俊雄

    第101回日本消化器病学会近畿支部例会  2014 

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  • 薬剤性消化管傷害と腸内細菌 Invited Domestic conference

    渡辺俊雄, 谷川徹也, 荒川哲男

    第12回日本機能性食品医用学会  2014 

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    Presentation type:Symposium, workshop panel (nominated)  

  • Helicobacter pylori誘発胃炎におけるToll-like receptor 9の意義 Domestic conference

    大谷恒史, 渡辺俊雄, 谷川徹也, 灘谷祐二, 田中史生, 鎌田紀子, 山上博一, 斯波将次, 富永和作, 藤原靖弘, 荒川哲

    第20回日本ヘリコバクター学会総会  2014 

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  • 非ステロイド系抗炎症薬起因性小腸傷害におけるインフラマソームおよびinterleukin-1βの意義 Domestic conference

    谷川徹也, 東森啓, 渡辺俊雄

    第100回日本消化器病学会総会  2014 

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  • レバミピドの小腸内フローラ調節作用と非ステロイド系抗炎症薬起因性小腸傷害抑制作用およびプロトンポンプ阻害薬による本傷害の増悪に対する作用について Domestic conference

    谷川徹也, 東森啓, 渡辺俊雄,

    第56回日本消化器病学会大会  2014 

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  • NSAID起因性小腸傷害の病態からみた治療戦略 Invited Domestic conference

    渡辺俊雄

    第50回日本消化器免疫学会総会  2013.08 

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    Presentation type:Public lecture, seminar, tutorial, course, or other speech  

  • Reduction of NSAID-induced enteropathy in rheumatoid arthritis patients receiving anti-tumor necrosis factor therapy: A propensity-matched analysis The 21th United  International conference

    T. Watanabe, T. Tanigawa, M. Shiba, Y. Nadatani, Y. Nagami, S. Sugimori, K. Tominaga, Y. Fujiwara, T.Arakawa

    European Gastroenterogy week (Berlin)  2013 

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  • Propensity-score マッチング解析を用いた非ステロイド系抗炎症薬服用関節リウマチ患者における小腸傷害の発症と高年齢との関連性の検討 Domestic conference

    谷川徹也, 斯波将次, 渡辺俊雄

    第86回日本消化器内視鏡学会総会  2013 

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  • 小腸におけるレバミピドの腸内フローラ調節作用:非ステロイド性抗炎症薬起因性小腸傷害予防薬としての可能性 Domestic conference

    谷川徹也, 渡辺俊雄, 荒川哲男

    第41回日本潰瘍学会  2013 

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  • Reduction of NSAID-induced small intestinal damage in rheumatoid arthritis patients receiving anti-tumor necrosis factor therapy: A cohort study and propensity-matched analysis International conference

    Watanabe T, Tanigawa T, Shiba M, Nadatani Y, Nagami Y, Sugimori S, Yamagami H, Watanabe K, Tominaga K, Fujiwara Y, Koike T, Arakawa T

    The 114th Annual Meeting of the AGA (Orland)   2013 

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  • Activation of the MyD88 signaling pathway inhibits ischemia-reperfusion injury in the small intestine International conference

    Watanabe T, Kobata A,Tanigawa T, Yuji Nadatani,Yamagami H, Watanabe K, Tominaga K, Fujiwara Y, Takeuchi K, Arakawa T Activation of the MyD88 signaling pathway inhibits ischemia-reperfusion injury in the small intestine

    7th International Symposium on Cell/Tissue Injury and Cytoprotection/Organo-protection (Honolulu)   2012.09 

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  • Prevalence and risk factors of severe non-steroidal anti-inflammatory drug-induced small intestinal damage in patients with rheumatoid arthritis International conference

    Watanabe T, Tanigawa T, Nadatani Y, Nagami Y,Sugimori S, Okazaki H, Machida H, Yamagami H,Watanabe K, Tominaga K, Fujiwara Y, Koike T, Arakawa T

    The 113th Annual Meeting of the AGA (San Diego)   2012 

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  • 関節リウマチ患者における非ステロイド系抗炎症薬起因性小腸傷害発症の危険因子の検討 Domestic conference

    灘谷祐二, 谷川徹也, 渡辺俊雄

    第83回 日本消化器内視鏡学会総会  2012 

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  • Activation of the MyD88 signaling pathway inhibits ischemia-reperfusion injury in the small intestine International conference

    Watanabe T, Kobata A,Tanigawa T, Yuji Nadatani,Yamagami H, Watanabe K, Tominaga K, Fujiwara Y, Takeuchi K, Arakawa T

    国際薬理学会(IUPHAR)GIサテライト会議(Tokyo)  2012 

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  • 経皮的冠動脈形成術後の消化管出血に関する検討 Domestic conference

    灘谷 祐二, 渡辺 俊雄, 谷川 徹也, 大谷 恒史, 町田 浩久, 岡崎 博俊, 山上 博一, 渡辺 憲治, 富永 和作, 藤原 靖弘, 荒川 哲男

    第39回日本潰瘍学会  2011 

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  • 経皮的冠動脈形成術後における消化管出血の頻度ならびに患者背景に関する検討 Domestic conference

    灘谷祐二,  渡辺俊雄, 荒川哲男

    第6回日本消化管学会総会学術集会  2010 

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  • PATHOGENESIS AND MANAGEMENT OF NSAID-INDUCED SMALL INTESTINAL DAMAGE Invited International conference

    Watanabe T, Tanigawa T, Tominaga K, Fujiwara Y, Arakawa T

    The 13th International Conference on Ulcer Research (Split, Croatia)   2009.09 

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  • NSAID-induced small bowel injury is reduced in patients with rheumatoid arthritis receiving anti-tumor necrosis factor-alpha therapy International conference

    Watanabe T, Nagami Y, Sugimori S, Kameda N, Okazaki H, Machida H, Yamagam Hi, Tanigawa T, Watanabe K, Tominaga K, Fujiwara Y, Oshitani N, Koike T, Arakawa T

    The 110th Annual Meeting of the AGA (Chicago)   2009 

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  • NSAIDsと抗リウマチ薬の併用による小腸傷害の発症頻度に関する研究 Domestic conference

    渡辺俊雄, 杉森聖司, 永見康明

    第95回日本消化器病学会総会  2009 

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  • 経皮的冠動脈形成術後の消化管出血に関する検討 Domestic conference

    灘谷祐二, 渡辺俊雄, 藤原靖弘

    第51回日本消化器病学会大会  2009 

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  • 低用量アスピリン製剤による小腸粘膜傷害とミソプロストールの治療効果の検討 Domestic conference

    渡辺俊雄,杉森聖司, 永見康明, 亀田夏彦, 岡崎博俊, 町田浩久, 山上博一, 谷川徹也, 渡辺憲治, 富永和作, 藤原靖弘, 押谷伸英, 荒川哲男

    第5回日本消化管学会総会  2009 

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  • カプセル内視鏡による低用量アスピリン起因性小腸粘膜傷害の検討 Domestic conference

    渡辺俊雄, 永見康明, 岡崎博俊

    第77回日本消化器内視鏡学会総会  2009 

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  • Incidence of small bowel injury by low-dose enteric-coated aspirin and efficacy of misoprostol in treating it-a pilot study with capsule endoscopy International conference

    Watanabe T, Sugimori S, Kameda N, Okazaki H, Tanigawa T, Watanabe K, Tominaga K, Fujiwara Y, Oshitani N, Higuchi K, Arakawa T

    The 109th Annual Meeting of the AGA (Washington DC)   2008 

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  • NSAIDs起因性小腸傷害に対する治療戦略 Invited Domestic conference

    渡辺俊雄, 荒川哲男

    日本薬学会第128年会  2008 

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    Presentation type:Symposium, workshop panel (nominated)  

  • 小腸虚血再灌流傷害におけるMyD88の役割 Domestic conference

    渡辺俊雄, 谷川徹也, 荒川哲男

    第94回日本消化器病学会総会  2008 

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  • NSAID起因性小腸潰瘍に対するLactobacillus casei strain Shirotaの予防効果の基礎的検討 Domestic conference

    渡辺俊雄, 藤原靖弘, 荒川哲男

    第50回日本消化器病学会大会  2008 

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  • Indomethacin may injure the small intestine through a Toll-like receptor 4/MyD88-dependent pathway International conference

    Watanabe T, Fujiwara Y,Kobata A, Nishio H, Tanigawa T, Shiba M, Tominaga K, Oshitani N, Asahara T, Nomoto K, Takeuchi K, Higuchi K, Arakawa T

    1st International Gastrointestinal Consensus Symposium (Osaka)   2008 

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  • Ischemia-reperfusion injury in small intestine is mediated by toll-like receptor 2 International conference

    Watanabe T, Tanigawa T,Tominaga K, Watanabe K, Fujiwara Y, Oshitani N, Takeuchi K, Arakawa T

    The 109th Annual Meeting of the AGA (Washington DC)  2008 

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  • Prostaglandin E2 derived from cyclooxygenase-2 suppresses expression of Th1 cytokine in gastric mucosa infected with Helicobacter pylori. International conference

    Watanabe T, Higuchi K, Taira K, Tanigawa T, Shiba M, Tominaga K, Fujiwara Y, Oshitani N, Arakawa T

    The 13th International Congress of Mucosal Immunology (Tokyo)   2007 

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  • 慢性疲労ストレスが胃排出機能におよぼす影響と介在因子の検討 Domestic conference

    富永和作, 越智正博, 谷川徹也, 斯波将次, 渡辺俊雄, 藤原靖弘, 押谷伸英, 樋口和秀, 荒川哲男

    第39回胃病態機能研究会  2007 

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  • カプセル内視鏡を用いた低用量アスピリン製剤による小腸粘膜傷害とミソプロストールの治療効果の検討 Domestic conference

    渡辺俊雄, 杉森聖司, 樋口和秀

    第49回日本消化器病学会大会  2007 

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  • 小腸粘膜傷害はグラム陰性菌によるToll-like receptor 4/MyD88経路の活性化により惹起される Domestic conference

    渡辺俊雄, 谷川徹也, 斯波将次, 富永和作, 藤原靖弘, 押谷伸英, 樋口和秀, 荒川哲男

    第35回日本潰瘍学会  2007 

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  • カプセル内視鏡を用いた低用量アスピリン腸溶剤による小腸粘膜傷害の検討 Domestic conference

    渡辺俊雄, 杉森聖司, 樋口和秀

    第73回日本消化器内視鏡総会  2007 

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  • Toll-like receptor (TLR)2-and TLR4-mediated signals delay healing of gastric ulcer in mice International conference

    Watanabe T, Higuchi K, Kobata A, Tanigawa T, Shiba M, Tominaga K, Fujiwara Y, Oshitani N, Arakawa T

    The 108th Annual Meeting of the AGA (Washington DC)   2007 

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  • Proinflammatory effects of endothelial nitric oxide synthase in Helicobacter pylori infection. International conference

    Watanabe T, Higuchi K, Tanigawa T, Sasaki E.J., Shiba M, Tominaga K, Fujiwara Y, Oshitani N, Arakawa T

    The 107th Annual Meeting of the AGA (Los Angeles)   2006 

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  • 治療の過去・現在・未来, 防御因子製剤 Domestic conference

    荒川哲男, 樋口和秀, 渡辺俊雄

    第48回日本消化器病学会大会  2006 

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  • NSAIDs惹起性小腸潰瘍に対するLactobacillus casei strain Shirotaの予防効果 Domestic conference

    渡辺俊雄, 樋口和秀, 西尾光, 谷川徹也, 佐々木英二, 斯波将次, 富永和作, 藤原靖弘, 押谷伸英, 朝原崇, 野本康二, 竹内孝治, 荒川哲男

    第2回日本消化管学会総会  2006 

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  • Role of toll-like receptor 4 in indomethacin-induced small intestinal damage. International conference

    Watanabe T, Higuchi K, Tanigawa T, Sasaki E, Shiba M, Tominaga K, Fujiwara Y, Oshitani N, Arakawa T

    The 12th International Conference on Ulcer Research (Osaka)  2006 

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  • Susceptibility of gastric mucosa to indomethacin after eradication of H. pylori - Effect of prostaglandin E-2 and rebamipide. International conference

    Watanabe T, Higuchi K, Taira K, Sasaki E, Shiba M, Tominaga K, Fujiwara Y, Oshitani N, Arakawa T

    The 106th Annual Meeting of the AGA (Chicago)   2005 

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  • NSAIDsに対する胃粘膜の感受性の亢進はH. pylori除菌早期では低下しない-有効な除菌後維持療法に関する検討 Domestic conference

    渡辺俊雄, 平良高一, 樋口和秀

    第91回日本消化器病学会総会  2005 

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  • 六君子湯治療によるFunctional dyspepsia患者の胃排出能および自覚症状変化 Domestic conference

    富永和作,  渡辺俊雄, 樋口和秀

    第69回日本消化器内視鏡学会総会  2005 

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  • Indomethacin誘発性小腸潰瘍の発生過程におけるToll-like receptor 4の役割 Domestic conference

    渡辺俊雄,  大和正典, 樋口和秀

    第91回日本消化器病学会総会  2005 

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  • Involvement of Toll-like receptor 4 in indomethacin-induced small intestinal damage and prevention of damage by probiotic Lactobacillus casei. International conference

    Watanabe T, Higuchi K, Yamato M, Sasaki E, Shiba M, Tominaga K, Fujiwara Y, Oshitani N, Takeuchi K, Arakawa T

    The 106th Annual Meeting of the AGA (Chicago)   2005 

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  • Regulation of gastric prostaglandin E-2 synthesis by acid in mice infected with Helicobacter pylori - Role of vanilloid type-1 receptors. International conference

    Watanabe T, Higuchi K, Taira K, Hamaguchi M, Tanigawa T, Shiba M, Tominaga K, Fujiwara Y, Oshitani N, Matsumoto T, Arakawa T

    The 105th Annual Meeting of the AGA (New Orleans)   2004 

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  • 胃粘膜防御機構からみたH. pylori感染胃粘膜におけるcyclooxygenase-2の意義 Domestic conference

    平良高一 渡辺俊雄, 樋口和秀

    第90回日本消化器病学会総会  2004 

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  • 胃癌組織のVEGF産生におけるPGE2とそのレセプターの役割に関する検討 Domestic conference

    渡辺俊雄, 藤田春紀, 樋口和秀

    第90回日本消化器病学会総会  2004 

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  • Immunoneutralization of monocyte chemotactic protein-1 inhibited recurrence of gastric ulcer induced by tnf-a in rats. International conference

    Watanabe T, Higuchi K, Hamaguchi M, Shiba M, Tominaga K, Fujiwara Y, Oshitani N, Matsumoto T, Arakawa T

    The 104th Annual Meeting of the AGA (Orlando)   2003 

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  • 特発性血小板減少性紫斑病 (ITP) に対するH. pylori除菌療法の意義 Domestic conference

    樋口和秀, 藤原靖弘, 渡辺俊雄

    第89回日本消化器病学会総会  2003 

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  • H. pylori感染診断におよぼす抗潰瘍薬の影響について-7種類の防御因子系薬剤に関するprospective randomized study Domestic conference

    樋口和秀, 藤原靖弘, 渡辺俊雄

    第45回日本消化器病学会大会  2003 

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  • NSAIDsはH. pyloriによる胃粘膜傷害を増悪させるか Domestic conference

    渡辺俊雄, 樋口和秀, 荒川哲男

    第45回日本消化器病学会大会  2003 

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  • H. pylori除菌後の胃潰瘍再発の頻度とその背景因子に関する検討 Domestic conference

    渡辺俊雄, 富永和作, 藤原靖弘

    第70回日本消化器内視鏡学会近畿地方会  2003 

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  • Helicobacter pylori感染胃粘膜における粘膜防御機構-バニロイド受容体の役割 Domestic conference

    浜口正輝, 渡辺俊雄, 樋口和秀

    第45回日本消化器病学会大会  2003 

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  • GERD症例に対するオーダーメイド医療 Domestic conference

    富永和作, 渡辺俊雄, 藤原靖弘

    第78回日本消化器病学会近畿支部例会  2003 

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  • Induction of Gastric Ulcer Recurrence by Tumor Necrosis Factor-a: Roles of Chemokines International conference

    T Watanabe, K Higuchi, M Hamaguchi, K Tominaga, T Uchida, Y Fujiwara, T Matsumoto, T Arakawa.

    The 103th Annual Meeting of The American Gastroenterological Association (SanFrancisco)   2002 

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  • H. pylori除菌後の胃潰瘍再発症例の検討 Domestic conference

    渡辺俊雄, 藤原靖弘, 樋口和秀

    第68回日本消化器内視鏡学会近畿地方会  2002 

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  • H. pylori除菌成功後の抗潰瘍治療は必要か Domestic conference

    樋口和秀, 藤原靖弘, 渡辺俊雄

    第88回日本消化器病学会総会  2002 

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    Presentation type:Symposium, workshop panel (public)  

  • Helicobacter pylori培養上清液のラット急性逆流性食道炎に及ぼす影響 Domestic conference

    藤原靖弘, 樋口和秀, 富永和作, 渡辺俊雄, 内田俊之, 荒川哲男

    第8回日本ヘリコバクター学会  2002 

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    Presentation type:Symposium, workshop panel (public)  

  • Helicobacter pylori感染マウスにおける胃粘膜の炎症反応に対するNSAIDsの影響 Domestic conference

    谷川徹也, 渡辺俊雄, 浜口正輝, 佐々木英二, 富永和作, 内田俊之, 藤原靖弘, 押谷伸英, 樋口和秀, 松本誉之, 荒川哲男

    第39回日本消化器免疫学会総会  2002 

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    Presentation type:Symposium, workshop panel (public)  

  • 特発性血小板減少性紫斑病に対するH. pylori除菌療法の効果 Domestic conference

    樋口和秀, 藤原靖弘, 富永和作, 渡辺俊雄, 内田俊之, 荒川哲男

    第8回日本ヘリコバクター学会  2002 

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    Presentation type:Symposium, workshop panel (public)  

  • Helicobacter pylori感染マウスにおける胃粘膜の好中球浸潤に対するNSAIDsの影響 Domestic conference

    谷川徹也, 渡辺俊雄, 浜口正輝, 佐々木英二, 富永和作, 内田俊之, 藤原靖弘, 押谷伸英, 樋口和秀, 松本誉之, 荒川哲男

    第8回日本ヘリコバクター学会  2002 

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    Presentation type:Symposium, workshop panel (public)  

  • 除菌後に発生するsymptomatic GERDの頻度とその背景因子についての検討 Domestic conference

    山森一樹, 藤原靖弘, 斯波将次, 渡辺俊雄, 富永和作, 内田俊之, 樋口和秀, 荒川哲男

    第8回日本ヘリコバクター学会  2002 

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  • Requirement for gastric acid in a rat model of gastric ulcer relapse caused by interleukin-1β International conference

    Watanabe T, Higuchi K, Hamaguchi M, Tanigawa T,Sasaki E, Tominaga K, Uchida T, Fujiwara Y, Arakawa T

    第14回世界薬理学学サテライトシンポジウム (Hawaii)   2002 

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    Presentation type:Symposium, workshop panel (public)  

  • Neutrophils delay gastric ulcer healing by inhibiting angiogenesis in rats: Involvement of antiangiogenic effect of tumor necrosis factor-a. International conference

    Watanabe T, Higuchi K, Hamaguchi M, Tominaga K, Fujiwara Y, Arakawa T

    The 102th Annual Meeting of The American Gastroenterological Association (Atlanta)  2001 

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    Presentation type:Poster presentation  

  • Helicobacter pylori感染スナネズミの粘膜固有層に発達するリンパ濾胞と付随粘膜上皮の構造 Domestic conference

    渡辺俊雄, 樋口和秀, 荒川哲男

    第74回日本消化器病学会近畿支部例会  2001 

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    Presentation type:Symposium, workshop panel (public)  

  • ラット食道炎モデルにおけるEpidermal growth factor receptor, Transforming growth factor-αの動態, Domestic conference

    藤原靖弘, 樋口和秀, 浜口正輝, 高島隆, 渡辺俊雄, 富永和作, 押谷伸英, 松本誉之, 荒川哲男

    第29回実験潰瘍学会  2001 

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    Presentation type:Symposium, workshop panel (public)  

  • ラット酢酸胃潰瘍治癒に対する外因性15-deoxy-Δ12, 14-prostaglandin J2の影響 Domestic conference

    浜口正輝, 渡辺俊雄, 樋口和秀, 谷川徹也, 高島隆, 佐々木英二, 富永和作, 藤原靖弘, 荒川哲男

    29回実験潰瘍学会  2001 

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    Presentation type:Symposium, workshop panel (public)  

  • 胃潰瘍治癒過程における好中球および炎症性サイトカインの役割 Domestic conference

    渡辺俊雄, 樋口和秀, 浜口正輝, 富永和作, 藤原靖弘, 荒川哲男

    第28回日本実験潰瘍学会大会  2000 

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  • T Roles of gastric acid during the development of gastric ulcer recurrence caused by interleukin-1β in rats. International conference

    Watanabe T, Arakawa T, Higuchi K, Shimizu N, Tominaga K, Fujiwara Y, Takaishi O, Kuroki

    The 100th Annual Meeting of The American Gastroenterological Association (Orland)  1999 

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    Presentation type:Poster presentation  

  • Role of gastric acid in rat model of gastric ulcer relapse caused by interleukin-1β International conference

    T.Watanabe, T.Arakawa, K.Tominaga, T.Fukuda, K.Higuchi, Y.Fujiwara, O.Takaishi, K.Yamasaki, K.Kobayashi, T.Kuroki

    The 11th World Congress of Gastroenterology (Viena)  1998 

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    Presentation type:Poster presentation  

  • 胃粘膜傷害の初期治癒過程におけるDNA合成とポリアミン動態 Domestic conference

    大谷健二郎, 富永和作,  渡辺俊雄, 藤原靖弘, 高石修, 内田俊之, 福田隆, 樋口和秀, 荒川哲男, 黒木哲夫

    第26回日本実験潰瘍学会  1998 

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    Presentation type:Symposium, workshop panel (public)  

  • Role of neutrophil and its adhesion molecules in the development of gastric ulcer induced by submucosal injection of endothelin-1 in rats International conference

    T.Watanabe, T.Arakawa, T.Fukuda, K.Tominaga, Y.Fujiwara, K.Higuchi, O.Takaishi, K.Yamasaki, K.Kobayashi, T.Kuroki

    The 99th Annual Meeting of The American Gastroenterological Association (New Oleans)  1998 

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    Presentation type:Poster presentation  

  • Inhibition of gastric acid secretion by omeprazole prevents gastric ulcer relapse caused by interrleukin-1β in rats International conference

    T.Watanabe, T.Arakawa, T.Fukuda, K.Higuchi, Y.Fujiwara, O.Takaishi, K.Yamasaki, K.Kobayashi, T.Kuroki

    The 99th Annual Meeting of The American Gastroenterological Association (New Oleans)  1998 

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    Presentation type:Poster presentation  

  • REBAMIPIDE ACCERERATES HEALING AND REDUCES RELAPSE OF ACETIC ACID-INDUCED GASTRIC ULCER IN RAT International conference

    Watanabe T, Arakawa T, Fukuda T, Higuchi K, Takaishi O, Yamasaki K, Kuroki T, Kobayashi K

    9th International Conference on Ulcer Research (HongKong)  1997 

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    Presentation type:Poster presentation  

  • Requirement for gastric acid in a rat model of gastric ulcer relapse by Interleukin-1β International conference

    T.Watanabe, T.Arakawa, T.Fukuda, K.Higuchi, Y.Fujiwara, K.Kobayashi, T.Kuroki 

    International Symposium on Inflammation and Mucosal Injury.  (Hawaii)  1997 

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    Presentation type:Poster presentation  

  • IL-1βによる酢酸潰瘍再発とその機序に関する検討 Domestic conference

    渡辺俊雄, 荒川哲男, 樋口和秀, 福田隆,  小林絢三

    第24回日本実験潰瘍学会  1996.12 

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    Presentation type:Symposium, workshop panel (public)  

  • ROLE OF NEUTROPHILS IN A RAT MODEL OF ULCER RELAPSE CAUSED BY INTERLEUKIN 1β International conference

    Watanabe T, Arakawa T, Fukuda T, Higuchi K, Kobayashi K

    he 10th Asian-Pacific Congress of Gastroenterology (Yokohama)  1996 

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    Presentation type:Poster presentation  

  • ROLES OF ADHESION MOLECULES IN A RAT MODEL OF ULCER RELAPSE CAUSED BY INTERLEUKIN 1β International conference

    Watanabe T, Arakawa T

    第82回日本消化器病学会総会  1996 

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    Presentation type:Symposium, workshop panel (nominated)  

  • 炎症の観点からみた防御因子増強剤のQOUHにおける意義 Domestic conference

    樋口和秀, 渡辺俊雄

    第38回日本消化器病学会大会  1996 

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    Presentation type:Symposium, workshop panel (public)  

  • Role of neutrophils in ulcer relapse caused by interleukin 1β in rats International conference

    T.Watanabe, T.Arakawa, T.Fukuda, K.Higuchi, K.Kobayashi 

    The 97th Annual Meeting of The American Gastroenterological Association (San Francisco)  1996 

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    Presentation type:Poster presentation  

  • Relapse caused by interleukin 1β of experimental gastric ulcer via ICAM-1- and LFA-1-dependent mechanism International conference

    T.Watanabe, T.Arakawa, T.Fukuda, K.Higuchi, K.Kobayashi

    The 96th Annual Meeting of The American Gastroenterological Association (SanDiego)  1995 

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    Presentation type:Poster presentation  

  • 消化性潰瘍再発予防に対する新しい試み Domestic conference

    樋口和秀, 渡辺俊雄

    第37回日本消化器病学会大会  1995 

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    Presentation type:Symposium, workshop panel (public)  

  • Expression of adhesion molecules in experimental gastric ulcer in rats International conference

    T.Watanabe, T.Arakawa, K.Higuchi, T.Fukuda, K.Kobayashi 

    The 8th International Conference on Ulcer Research (Kyoto)  1994 

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    Presentation type:Oral presentation (general)  

  • Expression of adhesion molecules in chronic gastric ulcers in rat International conference

    T.Watanabe, T.Arakawa, Y.Watanabe, S.Nakamura, K.Higuchi, T.Fukuda, K.Kobayashi

    The 95th Annual Meeting of The American Gastroenterological Association (NewOrleans)  1994 

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    Presentation type:Poster presentation  

  • Effect of low dose of indomethacin on healing and recurrence of acetic acid-induced gastric ulcers in rats International conference

    T.Watanabe, T.Arakawa, H.Nebiki, K.Higuchi, T.Fukuda, K.Kobayashi 

    Second Osaka International Symposium on Gastroenterology (Osaka)   1993 

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    Presentation type:Oral presentation (general)  

  • 酢酸潰瘍治癒過程および潰瘍瘢痕における赤外線電子内視鏡およびfluorescein蛍光内視鏡所見の比較-胃粘膜血流, 再生粘膜成熟度からみた両検査法の意義 Domestic conference

    渡辺俊雄, 福田隆

    第43回日本消化器内視鏡学会総会  1992 

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    Presentation type:Symposium, workshop panel (public)  

  • 胃粘膜プロスタグランジン欠乏とQOU Domestic conference

    荒川哲男,  渡辺俊雄, 小林絢三

    第20回日本実験潰瘍学会  1992 

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    Presentation type:Symposium, workshop panel (public)  

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Grant-in-Aid for Scientific Research

  • Development of prophylaxis and therapeutics for autoimmune gastritis targeting gastric mucosa-associated microbiota and follicular regulatory T cell

    Grant-in-Aid for Scientific Research(C)  2024

  • https://www-kofu.jsps.go.jp/kofu1/shinsei/shoriKanri/kadaiKanriList.do

    Grant-in-Aid for Scientific Research(C)  2024

  • 胃粘膜関連細菌叢と濾胞性制御性T細胞を標的とした自己免疫性胃炎の予防・治療法開発

    Grant-in-Aid for Scientific Research(C)  2023

  • 胃細菌叢変容作用からみた胃癌の化学予防法の確立

    Grant-in-Aid for Scientific Research(C)  2023

  • NSAIDs起因性小腸傷害における好中球細胞外トラップの役割と診断・治療法確立

    Grant-in-Aid for Scientific Research(C)  2023

  • 胃粘膜関連細菌叢と濾胞性制御性T細胞を標的とした自己免疫性胃炎の予防・治療法開発

    Grant-in-Aid for Scientific Research(C)  2022

  • 胃細菌叢変容作用からみた胃癌の化学予防法の確立

    Grant-in-Aid for Scientific Research(C)  2022

  • NSAIDs起因性小腸傷害における好中球細胞外トラップの役割と診断・治療法確立

    Grant-in-Aid for Scientific Research(C)  2019.04

  • インフラマソームからみたバレット食道の発生ならびに発癌機序の解明と予防法の確立

    Grant-in-Aid for Scientific Research(C)  2016.04

  • 胃内細菌叢をターゲットとした胃癌の予防・早期発見法の開発

    Grant-in-Aid for Scientific Research(C)  2013.04

  • プロスタグランジンの輸送・代謝機構からの胃癌の病態生理の解明

    Grant-in-Aid for Scientific Research(C)  2007.04

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Outline of education staff

  • 消化器内科学

Charge of on-campus class subject

  • Trainig (2) in Premier Preventive Medicine

    2024     Graduate school

  • Trainig (1) in Premier Preventive Medicine

    2024     Graduate school

  • Clinical conference in Premier Preventive Medicine

    2024     Graduate school

  • Journal club in Premier Preventive Medicine

    2024     Graduate school

  • Seminar in Premier Preventive Medicine

    2024     Graduate school

  • Basic Course of Clinical Medicine

    2024     Graduate school

  • Clinical Medicine

    2024     Graduate school

  • 選択型クリニカルクラークシップ

    2022   Practical Training   Undergraduate

  • 上部消化管疾患の病態と治療

    2020     Undergraduate

  • 臨床推論:食欲低下、体重減少、体重増加

    2020     Undergraduate

  • 臓器別講義:消化管

    2020     Undergraduate

  • 臨床推論

    2019     Undergraduate

  • 臓器別講義:消化管

    2019     Undergraduate

  • 生体と薬物コース講義:消化器疾患治療薬

    2019     Undergraduate

  • 生体と薬物コース講義:消化器疾患治療薬

    2018     Undergraduate

  • 臨床推論

    2018     Undergraduate

  • 臓器別講義:消化管

    2018     Undergraduate

  • 臨床病態学(消化器系・運動器系)

    2017     Graduate school

  • 臓器別講義:消化管

    2017     Undergraduate

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Number of instructed thesis, researches

  • 2023

    Number of instructed the graduation thesis:

    [Number of instructed the Master's Program] (letter term):3

  • 2022

    Number of instructed the graduation thesis:

    [Number of doctoral thesis reviews] (vice-chief):2

  • 2021

    Number of instructed the graduation thesis:

    [Number of doctoral thesis reviews] (vice-chief):1

  • 2020

    Number of instructed the graduation thesis:

  • 2019

    Number of instructed the graduation thesis:

Original item・Special report (Social Activity)

  • 2023

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    Original item:消化器関連学会や医師会主催の研修会などで、「便秘」や「腸内細菌」に関する講演を10回程度行った。

Job title

  • Job title within the department

    School of Medicine 附属病院 先端予防医療部 

    所長  2022.04

Other

  • Job Career

    2009.10 - Now

  • Job Career

    2008.04 - 2009.09

  • Job Career

    2001.04 - 2003.03

  • Job Career

    1999.07 - 2001.03