Updated on 2025/02/27
Graduate School of Medicine Department of Basic Medical Science
Associate Professor 2022.04 - Now
School of Medicine Department of Medical Science
Associate Professor 2022.04 - Now
博士（農学） （ University of Tsukuba ）
Life Science / Pathological biochemistry
Life Science / Molecular biology
Proteostasis
Heat Shock Protein
Cancer
Proteomics
antibody therapeutic
プロテオスタシス（タンパク質の恒常性維持）は、細胞の生存にとって極めて重要であり、プロテオスタシスの破綻は疾患と深くリンクしている。特にがん細胞は、急速な増殖のために慢性的なストレス状態にあり、その生存はプロテオスタシスの亢進に強く依存している。このプロテオスタシスの制御機構の中心に位置するのが、分子シャペロンである一群の熱ショックタンパク質（HSP）である。 HSPは、タンパク質の適切なフォールディングの触媒、アポトーシス機構の調節、およびストレス条件下での変性タンパク質の修復または分解の選択と、タンパク質分解機構の調節に関わることで、細胞の生存を図っている。そこで、HSPの中でも細胞保護効果の最も強いHSP70に焦点をあて、HSP70が結合することで新生・修復・分解するタンパク質群を包括的に明らかにし、がんの病態や薬剤の治療抵抗性の機序の解明に取り組んでいる。
抗体医薬品としての臨床応用を目指した治療効果を有するモノクローナル抗体の作製を進めている。特に抗腫瘍活性を有する新規抗癌薬の創製を進めている。
抗腫瘍活性を有する抗体の創製
2022.04 - Now
proteostasis and disease
heat shock protein, stress, proteomics Joint Research in Japan
2010.04 - Now
日本分子生物学会
Domestic
日本薬理学会
Domestic
日本癌学会
Domestic
日本臨床ストレス応答学会
Domestic
Characterizing the toxicological responses to inorganic arsenicals and their metabolites in immortalized human bladder epithelial cells. Reviewed
Vachiraarunwong A, Gi M, Kiyono T, Suzuki S, Fujioka M, Qiu G, Guo R, Yamamoto T, Kakehashi A, Shiota M, Wanibuchi H
Archives of toxicology 2024.04（ ISSN:0340-5761 ）
Oikawa D, Gi M, Kosako H, Shimizu K, Takahashi H, Shiota M, Hosomi S, Komakura K, Wanibuchi H, Tsuruta D, Sawasaki T, Tokunaga F
Cell death & disease 13 ( 8 ) 694 2022.08
Matsue T, Gi M, Shiota M, Tachibana H, Suzuki S, Fujioka M, Kakehashi A, Yamamoto T, Kato M, Uchida J, Wanibuchi H
Cancer science 113 ( 8 ) 2642 - 2653 2022.08（ ISSN:1347-9032 ）
Mayuko Osada-Oka, Hikaru Kuwamura, Risa Imamiya, Keiko Kobayashi, Yukiko Minamiyama, Katsuyuki Takahashi, Masako Tanaka, Masayuki Shiota
European journal of pharmacology 920 174845 - 174845 2022.04（ ISSN:0014-2999 ）
ER membrane protein complex 1 interacts with STIM1 and regulates store-operated Ca2+ entry. Reviewed
Kazuhiko Kawata, Akemi Baba, Masayuki Shiota, Hideki Wanibuchi, Yoshihiro Baba
Journal of biochemistry 170 ( 4 ) 483 - 488 2021.12（ ISSN:0021-924X ）
Canopy Homolog 2 as a Novel Molecular Target in Hepatocarcinogenesis. Reviewed
Anna Kakehashi, Shugo Suzuki, Masayuki Shiota, Nina Raymo, Min Gi, Taro Tachibana, Vasily Stefanov, Hideki Wanibuchi
Cancers 13 ( 14 ) 2021.07（ ISSN:2072-6694 ）
Upregulation of PTK7 and β-catenin after vaginal mechanical dilatation: an examination of fibulin-5 knockout mice. Reviewed
Uemura R, Tachibana D, Shiota M, Yoshida K, Kitada K, Hamuro A, Misugi T, Koyama M
International urogynecology journal 2021.02（ ISSN:0937-3462 ）
Effects of orally active hypoxia inducible factor alpha prolyl hydroxylase inhibitor, FG4592 on renal fibrogenic potential in mouse unilateral ureteral obstruction model Reviewed
Kabei Kazuya, Tateishi Yu, Shiota Masayuki, Osada-Oka Mayuko, Nishide Shunji, Uchida Junji, Nakatani Tatsuya, Matsunaga Shinji, Yamaguchi Takehiro, Tomita Shuhei, Miura Katsuyuki
JOURNAL OF PHARMACOLOGICAL SCIENCES 142 ( 3 ) 93 - 100 2020.03（ ISSN:1347-8613 ）
The Autophagy-Related Protein GABARAP Is Induced during Overwintering in the Bean Bug (Hemiptera: Alydidae) Reviewed
Tachibana Shin-Ichiro, Matsuzaki Shinji, Tanaka Masako, Shiota Masayuki, Motooka Daisuke, Nakamura Shota, Goto Shin G.
JOURNAL OF ECONOMIC ENTOMOLOGY 113 ( 1 ) 427 - 434 2020.02（ ISSN:0022-0493 ）
Generation of Rat Monoclonal Antibodies Specific for Human Stromal Cell-Derived Factor-2 Reviewed
Tanaka M, Shiota M, Koyama M, Nakayama J, Yashiro M, Semba K, Goda N
Monoclon Antib Immunodiagn Immunother 39 ( 1 ) 23 - 26 2020.01
Effects of orally active hypoxia inducible factor alpha prolyl hydroxylase inhibitor, FG4592 on renal fibrogenic potential in mouse unilateral ureteral obstruction model. Reviewed
Kabei K, Tateishi Y, Shiota M, Osada-Oka M, Nishide S, Uchida J, Nakatani T, Matsunaga S, Yamaguchi T, Tomita S, Miura K.
J Pharmacol Sci. 142 ( 3 ) 93 - 100 2019.12
The Autophagy-Related Protein GABARAP Is Induced during Overwintering in the Bean Bug (Hemiptera: Alydidae). Reviewed
Tachibana SI, Matsuzaki S, Tanaka M, Shiota M, Motooka D, Nakamura S, Goto SG
Journal of Economic Entomology pii: toz287. 2019.11
Controlling the Phenotype of Tumor-Infiltrating Macrophages via the PHD-HIF Axis Inhibits Tumor Growth in a Mouse Model. Reviewed
Nishide S, Matsunaga S, Shiota M, Yamaguchi T, Kitajima S, Maekawa Y, Takeda N, Tomura M, Uchida J, Miura K, Nakatani T, Tomita S
iScience. 19 940 - 954 2019.08
Therapeutic Silencing of Centromere Protein X Ameliorates Hyperglycemia in Zebrafish and Mouse Models of Type 2 Diabetes Mellitus. Reviewed
Zang L, Shimada Y, Nakayama H, Chen W, Okamoto A, Koide H, Oku N, Dewa T, Shiota M, Nishimura N.
Frontiers in Genetics 10 693 2019.07
A dipeptidyl peptidase-4 (DPP-4) inhibitor, linagliptin, attenuates cardiac dysfunction after myocardial infarction independently of DPP-4. Reviewed
Yamaguchi T, Watanabe A, Tanaka M, Shiota M, Osada-Oka M, Sano S, Yoshiyama M, Miura K, Kitajima S, Matsunaga S, Tomita S, Iwao H, Izumi Y.
J Pharmacol Sci. 132 ( 2 ) 112 - 119 2018.12
Generation of Rat Monoclonal Antibodies Against a Deubiquitinase, Ovarian Tumor Domain-Containing Protein 1. Reviewed
Oikawa D, Shiota M, Goto E, Komakura K, Wanibuchi H, Tokunaga F
Monoclonal antibodies in immunodiagnosis and immunotherapy 37 ( 4 ) 180 - 184 2018.08
Generation of Rat Monoclonal Antibodies Specific for DZIP3. Reviewed
Oikawa D, Shiota M, Tokunaga F, Wanibuchi H
Monoclonal antibodies in immunodiagnosis and immunotherapy 37 ( 3 ) 153 - 157 2018.06
Role of hypoxia-inducible factor-1 in the development of renal fibrosis in mouse obstructed kidney: Special references to HIF-1 dependent gene expression of profibrogenic molecules. Reviewed
Kabei K, Tateishi Y, Nozaki M, Tanaka M, Shiota M, Osada-Oka M, Nishide S, Uchida J, Nakatani T, Tomita S, Miura K
Journal of pharmacological sciences 136 31 - 38 2017.12（ ISSN:1347-8613 ）
Heat shock protein 70 inhibitors suppress androgen receptor expression in LNCaP95 prostate cancer cells Reviewed
Kita Kazuaki, Shiota Masayuki, Tanaka Masako, Otsuka Asuka, Matsumoto Masaki, Kato Minoru, Tamada Satoshi, Iwao Hiroshi, Miura Katsuyuki, Nakatani Tatsuya, Tomita Shuhei
CANCER SCIENCE 108 ( 9 ) 1820 - 1827 2017.09（ ISSN:1349-7006 ）
Macrophage-derived exosomes induce inflammatory factors in endothelial cells under hypertensive conditions Reviewed
Osada-Oka Mayuko, Shiota Masayuki, Izumi Yasukatsu, Nishiyama Masaki, Tanaka Masako, Yamaguchi Takehiro, Sakurai Emi, Miura Katsuyuki, Iwao Hiroshi
HYPERTENSION RESEARCH 40 ( 4 ) 353 - 360 2017.04（ ISSN:0916-9636 ）
Protection of stromal cell-derived factor 2 by heat shock protein 72 prevents oxaliplatin-induced cell death in oxaliplatin-resistant human gastric cancer cells Reviewed
Takahashi Katsuyuki, Tanaka Masako, Yashiro Masakazu, Matsumoto Masaki, Ohtsuka Asuka, Nakayama Keiichi I., Izumi Yasukatsu, Nagayama Katsuya, Miura Katsuyuki, Iwao Hiroshi, Shiota Masayuki
CANCER LETTERS 378 ( 1 ) 8 - 15 2016.08（ ISSN:0304-3835 ）
Identification of low-abundance proteins in serum via the isolation of HSP72 complexes Reviewed
Tanaka Masako, Shiota Masayuki, Nakao Takafumi, Uemura Ryo, Nishi Satoshi, Ohkawa Yasuyuki, Matsumoto Masaki, Yamaguchi Maki, Osada-Oka Mayuko, Inagaki Azusa, Takahashi Katsuyuki, Nakayama Keiichi I., Gi Min, Izumi Yasukatsu, Miura Katsuyuki, Iwao Hiroshi
JOURNAL OF PROTEOMICS 136 214 - 221 2016.05（ ISSN:1874-3919 ）
Percutaneous Carbon Dioxide Treatment Using a Gas Mist Generator Attenuates the Development of Right Ventricular Dysfunction in Monocrotaline-induced Pulmonary Hypertensive Rats. Reviewed
Yamaguchi T, Izumi Y, Yamazaki T, Nakamura Y, Sano S, Shiota M, Miura K, Iwao H, Yoshiyama M
Osaka city medical journal 61 ( 1 ) 31 - 41 2015.06（ ISSN:0030-6096 ）
Percutaneous carbon dioxide mist treatment has protective effects in experimental myocardial infarction Reviewed
Yamaguchi Takehiro, Yamazaki Takanori, Nakamura Yasuhiro, Shiota Masayuki, Shimada Kenei, Miura Katsuyuki, Iwao Hiroshi, Yoshiyama Minoru, Izumi Yasukatsu
JOURNAL OF PHARMACOLOGICAL SCIENCES 127 ( 4 ) 474 - 480 2015.04（ ISSN:1347-8613 ）
Myeloid HIF-1 attenuates the progression of renal fibrosis in murine obstructive nephropathy Reviewed
Tateishi Yu, Osada-Oka Mayuko, Tanaka Masako, Shiota Masayuki, Izumi Yasukatsu, Ishimura Eiji, Motoyama Koka, Inaba Masaaki, Miura Katsuyuki
JOURNAL OF PHARMACOLOGICAL SCIENCES 127 ( 2 ) 181 - 189 2015.02（ ISSN:1347-8613 ）
Repeated remote ischemic conditioning attenuates left ventricular remodeling via exosome-mediated intercellular communication on chronic heart failure after myocardial infarction Reviewed
Yamaguchi Takehiro, Izumi Yasukatsu, Nakamura Yasuhiro, Yamazaki Takanori, Shiota Masayuki, Sano Soichi, Tanaka Masako, Osada-Oka Mayuko, Shimada Kenei, Miura Katuyuki, Yoshiyama Minoru, Iwao Hiroshi
INTERNATIONAL JOURNAL OF CARDIOLOGY 178 239 - 246 2015.01（ ISSN:0167-5273 ）
Izumi Yasukatsu, Yamaguchi Takehiro, Yamazaki Takanori, Yamashita Naoto, Nakamura Yasuhiro, Shiota Masayuki, Tanaka Masako, Sano Soichi, Osada-Oka Mayuko, Shimada Kenei, Wanibuchi Hideki, Miura Katsuyuki, Yoshiyama Minoru, Iwao Hiroshi
Japan Atherosclerosis Society Journal of Atherosclerosis and Thrombosis 22 ( 1 ) 38 - 51 2015（ ISSN:1340-3478 ）
A Noninvasive Metabolic Syndrome Model Using an Extremely Small Minipig, the Microminipig Reviewed
Yamaguchi Takehiro, Yamazaki Takanori, Kawaguchi Hiroaki, Tawa Masashi, Nakamura Yasuhiro, Shiota Masayuki, Osada-Oka Mayuko, Tanimoto Akihide, Okamura Tomio, Miura Katsuyuki, Iwao Hiroshi, Yoshiyama Minoru, Izumi Yasukatsu
The Japanese Pharmacological Society JOURNAL OF PHARMACOLOGICAL SCIENCES 126 ( 2 ) 168 - 171 2014.10（ ISSN:1347-8613 ）
Establishment of neutralizing rat monoclonal antibodies for fibroblast growth factor-2. Reviewed
Tanaka M, Yamaguchi M, Shiota M, Kawamoto Y, Takahashi K, Inagaki A, Osada-Oka M, Harada A, Wanibuchi H, Izumi Y, Miura K, Iwao H, Ohkawa Y
Monoclonal antibodies in immunodiagnosis and immunotherapy 33 ( 4 ) 261 - 9 2014.08
Hsc70 Contributes to Cancer Cell Survival by Preventing Rab1A Degradation under Stress Conditions Reviewed
Tanaka Masako, Mun Saya, Harada Akihito, Ohkawa Yasuyuki, Inagaki Azusa, Sano Soichi, Takahashi Katsuyuki, Izumi Yasukatsu, Osada-Oka Mayuko, Wanibuchi Hideki, Yamagata Masayo, Yukimura Tokihito, Miura Katsuyuki, Shiota Masayuki, Iwao Hiroshi
PLOS ONE 9 ( 5 ) e96785 2014.05（ ISSN:1932-6203 ）
Lipid synthesis is promoted by hypoxic adipocyte-derived exosomes in 3T3-L1 cells Reviewed
Sano Soichi, Izumi Yasukatsu, Yamaguchi Takehiro, Yamazaki Takanori, Tanaka Masako, Shiota Masayuki, Osada-Oka Mayuko, Nakamura Yasuhiro, Wei Min, Wanibuchi Hideki, Iwao Hiroshi, Yoshiyama Minoru
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 445 ( 2 ) 327 - 333 2014.03（ ISSN:0006-291X ）
A novel feature of the HSP70 family Reviewed
Shiota Masayuki, Tanaka Masako
The Japanese Pharmacological Society, Folia Pharmacologica Japonica 143 ( 6 ) 310 - 312 2014（ ISSN:0015-5691 ）
Establishment of neutralizing rat monoclonal antibodies for fibroblast growth factor-2 Reviewed
Monoclonal Antibodies Immunodiagn. Immunother. 33 261 - 269 2014
Establishment of a 5-fluorouracil-resistant triple-negative breast cancer cell line Reviewed
Takahashi Katsuyuki, Tanaka Masako, Inagaki Azusa, Wanibuchi Hideki, Izumi Yasukatsu, Miura Katsuyuki, Nagayama Katsuya, Shiota Masayuki, Iwao Hiroshi
INTERNATIONAL JOURNAL OF ONCOLOGY 43 ( 6 ) 1985 - 1991 2013.12（ ISSN:1019-6439 ）
Tolvaptan Attenuates Left Ventricular Fibrosis Afer Acute Myocardial Infarction in Rats Reviewed
Yamazaki Takanori, Nakamura Yasuhiro, Shiota Masayuki, Osada-Oka Mayuko, Fujiki Hiroyuki, Hanataani Akihisa, Shimada kenei, Miura Katsuyuki, Yoshiyama Minoru, Iwao Hiroshi, Izumi Yasukatsu
The Japanese Pharmacological Society, The Japanese Journal of Pharmacology 123 ( 1 ) 58 - 66 2013.09（ ISSN:1347-8613 ）
Tolvaptan Improves Left Ventricular Dysfunction after Myocardial Infarction in Rats Reviewed
Yamazaki Takanori, Izumi Yasukatsu, Nakamura Yasuhiro, Yamashita Naoto, Fujiki Hiroyuki, Osada-Oka Mayuko, Shiota Masayuki, Hanatani Akihisa, Shimada Kenei, Iwao Hiroshi, Yoshiyama Minoru
CIRCULATION-HEART FAILURE 5 ( 6 ) 794 - 802 2012.11（ ISSN:1941-3289 ）
Pravastatin-induced proangiogenic effects depend upon extracellular FGF-2 Reviewed
Shiota Masayuki, Hikita Yuko, Kawamoto Yukiko, Kusakabe Hiromi, Tanaka Masako, Izumi Yasukatsu, Nakao Takafumi, Miura Katsuyuki, Funae Yoshihiko, Iwao Hiroshi
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE 16 ( 9 ) 2001 - 2009 2012.09（ ISSN:1582-1838 ）
Surf4 modulates STIM1-dependent calcium entry Reviewed
Fujii Yoko, Shiota Masayuki, Ohkawa Yasuyuki, Baba Akemi, Wanibuchi Hideki, Kinashi Tatsuo, Kurosaki Tomohiro, Baba Yoshihiro
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 422 ( 4 ) 615 - 620 2012.06（ ISSN:0006-291X ）
Dexmedetomidine infusion for sedation in the intensive care setting in an infant with airway compromise due to congenital mediastinal neuroblastoma Reviewed
Shiota Mitsutaka, Oda Yutaka, Taniguchi Masashi, Hamabata Takayuki, Mizumoto Hiroshi, Hata Daisuke
PEDIATRIC ANESTHESIA 22 ( 6 ) 603 - 605 2012.06（ ISSN:1155-5645 ）
Novel Device That Produces Carbon Dioxide Mist for Myocardial Infarction Treatment in Rats Reviewed
Yamazaki Takanori, Izumi Yasukatsu, Nakamura Yasuhiro, Hanatani Akihisa, Shimada Kenei, Muro Takashi, Shiota Masayuki, Iwao Hiroshi, Yoshiyama Minoru
The Japanese Circulation Society CIRCULATION JOURNAL 76 ( 5 ) 1203 - 1212 2012.05（ ISSN:1346-9843 ）
Samukawa Keiichi, Izumi Yasukatsu, Shiota Masayuki, Nakao Takafumi, Osada-Oka Mayuko, Miura Katsuyuki, Iwao Hiroshi
The Japanese Pharmacological Society JOURNAL OF PHARMACOLOGICAL SCIENCES 118 ( 3 ) 391 - 400 2012.03（ ISSN:1347-8613 ）
The antifibrotic agent pirfenidone inhibits angiotensin II-induced cardiac hypertrophy in mice Reviewed
YAMAZAKI Takanori, YAMASHITA Naoto, IZUMI Yasukatsu, NAKAMURA Yasuhiro, SHIOTA Masayuki, HANATANI Akihisa, SHIMADA Kenei, MURO Takashi, IWAO Hiroshi, YOSHIYAMA Minoru
Hypertension research : clinical and experimental : official journal of the Japanese Society of Hypertension 35 ( 1 ) 34 - 40 2012.01（ ISSN:09169636 ）
The antifibrotic agent pirfenidone inhibits angiotensin II-induced cardiac hypertrophy in mice Reviewed
Yamazaki Takanori, Yamashita Naoto, Izumi Yasukatsu, Nakamura Yasuhiro, Shiota Masayuki, Hanatani Akihisa, Shimada Kenei, Muro Takashi, Iwao Hiroshi, Yoshiyama Minoru
HYPERTENSION RESEARCH 35 ( 1 ) 34 - 40 2012.01（ ISSN:0916-9636 ）
Generation of a Rat Monoclonal Antibody Specific for Hsp72 Reviewed
Tanaka Masako, Shiota Masayuki, Okada Seiji, Harada Akihito, Odawara Jun, Mun Saya, Iwao Hiroshi, Ohkawa Yasuyuki
HYBRIDOMA 30 ( 4 ) 397 - 400 2011.08（ ISSN:1554-0014 ）
Severe prekallikrein deficiency due to a homozygous Trp499Stop nonsense mutation Reviewed
Nakao Takafumi, Yamane Takahisa, Katagami Tomoko, Shiota Masayuki, Izumi Yasukatsu, Samori Tomohiro, Hino Masayuki, Iwao Hiroshi
BLOOD COAGULATION & FIBRINOLYSIS 22 ( 4 ) 337 - 339 2011.06（ ISSN:0957-5235 ）
Machida Yuichi, Kitamoto Koichiro, Izumi Yasukatsu, Shiota Masayuki, Uchida Junji, Kira Yukimi, Nakatani Tatsuya, Miura Katsuyuki
The Japanese Pharmacological Society JOURNAL OF PHARMACOLOGICAL SCIENCES 114 ( 4 ) 464 - 473 2010.12（ ISSN:1347-8613 ）
Generation of a Rat Monoclonal Antibody Specific for Heat Shock Cognate Protein 70 Reviewed
Shiota Masayuki, Saiwai Hirokazu, Mun Saya, Harada Akihito, Okada Seiji, Odawara Jun, Tanaka Masako, Iwao Hiroshi, Ohkawa Yasuyuki
HYBRIDOMA 29 ( 5 ) 453 - 456 2010.10（ ISSN:1554-0014 ）
Heat Shock Cognate Protein 70 is essential for Akt signaling in Endothelial Function Reviewed
SHIOTA Masayuki, IZUMI Yasukatsu, NAKAO Takafumi, IWAO Hiroshi
33 ( 2 ) 49 - 54 2010.07（ ISSN:09114637 ）
内皮機能におけるHeat shock cognate protein 70(Hsc70)の役割 Reviewed
塩田 正之, 泉 康雄, 中尾 隆文, 岩尾 洋
日本心脈管作動物質学会 血管 33 ( 2 ) 49 - 54 2010.07（ ISSN:0911-4637 ）
Heat Shock Cognate Protein 70 Is Essential for Akt Signaling in Endothelial Function Reviewed
Shiota Masayuki, Kusakabe Hiromi, Izumi Yasukatsu, Hikita Yuko, Nakao Takafumi, Funae Yoshihiko, Miura Katsuyuki, Iwao Hiroshi
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 30 ( 3 ) 491 - U279 2010.03（ ISSN:1079-5642 ）
Kitamoto Koichiro, Machida Yuichi, Uchida Junji, Izumi Yasukatsu, Shiota Masayuki, Nakao Takafumi, Iwao Hiroshi, Yukimura Tokihito, Nakatani Tatsuya, Miura Katsuyuki
The Japanese Pharmacological Society JOURNAL OF PHARMACOLOGICAL SCIENCES 111 ( 3 ) 285 - 292 2009.11（ ISSN:1347-8613 ）
Pravastatin accelerates ischemia-induced angiogenesis through AMP-activated protein kinase Reviewed
Izumi Yasukatsu, Shiota Masayuki, Kusakabe Hiromi, Hikita Yuko, Nakao Takafumi, Nakamura Yasuhiro, Muro Takashi, Miura Katsuyuki, Yoshiyama Minoru, Iwao Hiroshi
HYPERTENSION RESEARCH 32 ( 8 ) 675 - 679 2009.08（ ISSN:0916-9636 ）
IZUMI Yasukatsu, OKATANI Hideaki, SHIOTA Masayuki, NAKAO Takafumi, ISE Ryota, KITO Go, MIURA Katsuyuki, IWAO Hiroshi
Hypertension research : clinical and experimental : official journal of the Japanese Society of Hypertension 32 ( 5 ) 339 - 346 2009.05（ ISSN:09169636 ）
Effects of metoprolol on epinephrine-induced takotsubo-like left ventricular dysfunction in non-human primates Reviewed
Izumi Yasukatsu, Okatani Hideaki, Shiota Masayuki, Nakao Takafumi, Ise Ryota, Kito Go, Miura Katsuyuki, Iwao Hiroshi
HYPERTENSION RESEARCH 32 ( 5 ) 339 - 346 2009.05（ ISSN:0916-9636 ）
Shiota Masayuki, Kusakabe Hiromi, Hikita Yuko, Nakao Takafumi, Izumi Yasukatsu, Iwao Hiroshi
The Japanese Pharmacological Society JOURNAL OF PHARMACOLOGICAL SCIENCES 107 ( 1 ) 15 - 19 2008.05（ ISSN:1347-8613 ）
Protein phosphatase 4 catalytic subunit regulates Cdk1 activity and microtubule organization via NDEL1 dephosphorylation. Reviewed
Toyo-oka K, Mori D, Yano Y, Shiota M, Iwao H, Goto H, Inagaki M, Hiraiwa N, Muramatsu M, Wynshaw-Boris A, Yoshiki A, Hirotsune S
The Journal of cell biology 180 ( 6 ) 1133 - 47 2008.03（ ISSN:0021-9525 ）
Protein phosphatase 4 catalytic subunit regulates Cdk1 activity and microtubule organization via NDEL1 dephosphorylation Reviewed
Toyo-oka Kazuhito, Mori Daisuke, Yano Yoshihisa, Shiota Masayuki, Iwao Hiroshi, Goto Hidemasa, Inagaki Masaki, Hiraiwa Noriko, Muramatsu Masami, Wynshaw-Boris Anthony, Yoshiki Atsushi, Hirotsune Shinji
JOURNAL OF CELL BIOLOGY 180 ( 6 ) 1133 - 1147 2008.03（ ISSN:0021-9525 ）
Interleukin-10 gene transfer to peritoneal mesothelial cells suppresses peritoneal dissemination of gastric cancer cells due to a persistently high concentration in the peritoneal cavity Reviewed
Tanaka F., Tominaga K., Shiota M., Ochi M., Kuwamura H., Tanigawa T., Watanabe T., Fujiwara Y., Oshitani N., Higuchi K., Iwao H., Arakawa T.
CANCER GENE THERAPY 15 ( 1 ) 51 - 59 2008.01（ ISSN:0929-1903 ）
Nakao Takafumi, Shiota Masayuki, Tatemoto Yasuyoshi, Izumi Yasukatsu, Iwao Hiroshi
The Japanese Pharmacological Society JOURNAL OF PHARMACOLOGICAL SCIENCES 105 ( 4 ) 334 - 341 2007.12（ ISSN:1347-8613 ）
Growth inhibition of colon cancer cells by transfection of dominant-negative apoptosis signal-regulating kinase-1. Reviewed
Kuwamura H, Tominaga K, Shiota M, Ashida R, Nakao T, Sasaki E, Watanabe T, Fujiwara Y, Oshitani N, Higuchi K, Ichijo H, Arakawa T, Iwao H
Oncology reports 17 ( 4 ) 781 - 6 2007.04（ ISSN:1021-335X ）
Pleiotropic effects of statins on endothelium and signaling mechanisms
SHIOTA Masayuki, IZUMI Yasukatsu, NAKAO Takafumi, IWAO Hiroshi
The Japanese Pharmacological Society, Folia Pharmacologica Japonica 128 ( 3 ) 161 - 166 2006.09（ ISSN:00155691 ）
Important role of apoptosis signal-regulating kinase 1 in ischemia-induced angiogenesis Reviewed
Izumi Y, Kim-Mitsuyama S, Yoshiyama M, Omura T, Shiota M, Matsuzawa A, Yukimura T, Murohara T, Takeya M, Ichijo H, Yoshikawa J, Iwao H
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 25 ( 9 ) 1877 - 1883 2005.09（ ISSN:1079-5642 ）
Beneficial Effect of Candesartan on Rat Diastolic Heart Failure Reviewed
Wake R, Kim-Mitsuyama S, Izumi Y, Yoshida K, Izumiya Y, Yukimura T, Shiota M, Yoshiyama M, Yoshikawa J, Iwao H.
The Japanese Pharmacological Society Journal of pharmacological sciences 98 ( 4 ) 372 - 379 2005.08（ ISSN:13478613 ）
Heat stress diminishes gonadotropin receptor expression and enhances susceptibility to apoptosis of rat granulosa cells. Reviewed
Shimizu T, Ohshima I, Ozawa M, Takahashi S, Tajima A, Shiota M, Miyazaki H, Kanai Y
Reproduction (Cambridge, England) 129 ( 4 ) 463 - 72 2005.04（ ISSN:1470-1626 ）
Gene, biosynthesis, and function of angiotensinogen. Invited
Shiota M, Izumi Y, Yukimura T, Iwao H
Nihon rinsho. Japanese journal of clinical medicine 63 Suppl 3 17 - 21 2005.03（ ISSN:0047-1852 ）
Protein tyrosine phosphatase LMW-PTP exhibits distinct roles between vascular endothelial and smooth muscle cells. Reviewed
Shimizu H, Toyama O, Shiota M, Kim-Mitsuyama S, Miyazaki H
Journal of receptor and signal transduction research 25 ( 1 ) 19 - 33 2005（ ISSN:1079-9893 ）
Tyrosine phosphatase epsilonm stimulates migration and survival of porcine aortic endothelial cells by activating c-src. Reviewed
Nakagawa Y, Yamada N, Shimizu H, Shiota M, Tamura M, Kim-Mitsuyama S, Miyazaki H.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 325 314 - 319 2004
Feeding is not a more potent zeitgeber than the light-dark cycle in drosophila. Reviewed
Shiota M, Oishi K, Sakamoto K, Kasamatsu M, Ishida N.
Neuroreport 15 739 - 743 2004
Gene expression profile in experimental mesangial proliferative glomerulonephritis. Reviewed
Izumi Y, Izumiya Y, Shiota M, Yukimura T, Shiojima S, Yamada M, Kadowaki T, Katsuma S, Hirasawa A, Tsujimoto G, Iwao H.
JOURNAL OF PHARMACOLOGICAL SCIENCES 96 91 - 94 2004
Correlation of mitogen-activated protein kinase activities with cell survival and apoptosis in porcine granulosa cells. Reviewed
Shiota M, Sugai N, Tamura M, Yamaguchi R, Fukushima N, Miyano T, Miyazaki H.
Zoological Science 20 193 - 201 2003
Protein tyrosine phosphatase PTP20 induces actin cytoskeleton reorganization by dephosphorylating p190 rhogap in rat ovarian granulosa cells stimulated with follicle-stimulating hormone. Reviewed
Shiota M, Tanihiro T, Nakagawa Y, Aoki N, Ishida N, Miyazaki K, Ullrich A, Miyazaki H.
Molecular Endocrinology 17 534 - 549 2003
Low m(r) protein tyrosine phosphatase inhibits growth and migration of vascular smooth muscle cells induced by platelet-derived growth factor. Reviewed
Shimizu H, Shiota M, Yamada N, Miyazaki K, Ishida N, Kim S, Miyazaki H.
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