2024/06/04 更新

写真a

レチイタントゥイ
LE THI THANH THUY 
LE THI THANH THUY 
担当
大学院医学研究科 臨床医科学専攻 准教授
医学部 医学科
職名
准教授
所属
医学研究院
連絡先
メールアドレス
プロフィール
Dr. Le is an Associate Professor at the Department of Global Education and Medical Sciences, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan. She earned her M.D. at Hanoi Medical University, Hanoi, Vietnam in 2001 with the top-first score. From 2002 to 2007, she has awarded the Japanese Monbusho scholarship for a Ph.D. course at Osaka University, concerning HBV genotypes in Vietnam. From 2007-2014, she was a postdoctoral fellow at Osaka University for 2 years. She started working at the Department of Hepatology, Graduate School of Medicine, Osaka City University from 2009 to present. She is interested in the pathophysiological role of hepatic stellate cells in liver fibrosis, steatohepatitis, cirrhosis, and cancer. Her works are concerned with the function, and mechanism action of Cytoglobin, a recently discovered globin by her professor, Norifumi Kawada. She uncovered the protective role of Cytoglobin in liver fibrosis and cancer which was registered 2 patents. She has published more than 30 peer-review papers including those in Nature Communications, Journal of Hepatology, Hepatology, Journal of Biological Chemistry, American Journal of Pathology, and Redox Biology; and 3 book chapters on Springer Nature, and Elsevier publishing groups. She has continuously got research grants from the Japan Society for the Promotion of Science since 2013. She has awarded other grants from the Liver forum in Kyoto in 2015; the Osaka Medical Research Foundation for Intractable Diseases Grant in 2016, Award of Gilead Science Research Scholar in Liver Diseases Asia, 2019. Currently, her research interests fall into the exploration of therapeutic targets for liver fibrosis and cancer. Education and International Cooperation: She is currently the instructor for 5 doctoral students (6 graduated up to date). She is the liaison for educational and research activities between Osaka Metropolitan University's Department of Hepatology and: Ohio State University; New York Medical College; Stanford University; University of Antwerp, Belgium; University of Fribourg, Switzerland; Hanoi Medical University, Ho Chi Minh City University of Medicine and Pharmacy, 108 Military Central Hospital, Saint-Paul General Hospital, and VinMec International Hospital.
所属キャンパス
阿倍野キャンパス

担当・職階

  • 大学院医学研究科 臨床医科学専攻 

    准教授  2023年04月 - 継続中

  • 医学部 医学科 

    准教授  2023年04月 - 継続中

取得学位

  • 博士(医学) ( 大阪大学 )

研究分野

  • ライフサイエンス / 消化器内科学

  • ライフサイエンス / 消化器内科学

研究キーワード

  • Cytoglobin, liver fibrosis, liver cancer, antioxidant, pancreatic cancer, bone cancer

研究概要

  • 1) Studying on molecular epidemiology of Hepatitis B Virus (HBV) which is one of the most serious viral hepatitis in Vietnam.
    2)Investigating microsatellite loci as biomarkers indicating genetic alterations induced in the germ cells of Chernobyl clean-up workers that were transmitted to the children.
    3) Examine the role of Cytoblogin in the pathophysiology of liver injuries, fibrosis, cirrhosis, and cancer, pancreatic cancer, and vascular diseases.
    4) Investigating the affect of viral and host genetic factors to the diagnosis and treatment response in chronic hepatitis C/B patients.
    5) Examining the role of immune checkpoint proteins in the development of liver cancer, hepatitis B/C.
    6) Exploration of anti-fibrotic and anti-cancer therapies based on single cell RNA sequencing analysis.

研究歴

  • Studying the molecular epidemiology of Hepatitis B Virus (HBV) which is one of the most serious viral hepatitis in Vietnam

    個人研究

    2002年10月 - 2005 

  • Investigating microsatellite loci as biomarkers indicating genetic alterations induced in the germ cells of Chernobyl clean-up workers that were transmitted to the children

    国内共同研究

    2002年10月 - 2005 

  • Examine the role of Cytoblogin in the pathophysiology of liver injuries, fibrosis, cirrhosis, and cancer, pancreatic cancer, and vascular diseases.

    2009年01月 - 継続中 

  • Investigating the affect of viral and host genetic factors to the diagnosis and treatment response in chronic hepatitis C/B patients

    2017 - 継続中 

  • Examining the role of immune checkpoint proteins in the development of liver cancer, hepatitis B/C.

    2017 - 継続中 

  • Exploration of anti-fibrotic and anti-cancer therapies based on single cell RNA sequencing analysis.

    2020 - 継続中 

所属学協会

  • American Association for the Study of Liver Diseases (AASLD)

  • The Japan Society of Gastroenterology (JSGE)

  • The Japan Society of Hepatology (JSH)

  • The Japan Society for Hepatic Sinusoidal Research (SHSR)

  • International Society for Hepatic Sinusoidal Research (ISHSR)

受賞歴

  • Poster award, 22nd International Symposium on Cells of Hepatic Sinusoid (ISCHS), Chicago, US, 4/2024

    2024年04月  

  • Young Investigator Award, 21st International Symposium on Cells of Hepatic Sinusoid (ISCHS), Shanghai, China, 9/2022

    2022年09月   21st International Symposium on Cells of Hepatic Sinusoid (ISCHS)  

  • APEC Science Leadership Program in Chiang Mai, Thailand, 8/2022

    2022年08月  

  • The Ichiro Kanehara Foundation Research Exchange Grant, 3/2022

    2022年03月  

  • Gilead Science Research Scholar Program in Liver Diseases Asia, 2/2019

    2019年02月   Gilead Science Research Scholar Program  

  • The Osaka Medical Research Foundation for Intractable Diseases Grant Award, 7/2016

    2016年07月  

  • The Japan Society of Hepatology (JSH) travel award for attending AASLD 2016 in Boston, USA

    2016   Japan Society of Hepatology (JSH)  

  • 18th International Symposium on Cells of Hepatic Sinusoid (ISCHS) Travel Award, Asilomar, California, USA, 11/2015

    2015年11月  

  • Liver Forum in Kyoto Grant Award, 2015

    2015年03月  

  • Osaka City Medical Association Prize at Osaka City University, 12/2011

    2011年12月  

  • 16th International Symposium on Cells of the Hepatic Sinusoid (ISCHS) Travel Awarded, Florence, Italy, 9/2011

    2011年09月  

  • Marco Foschi Prize for Research in GI Oncology at16th ISCHS meeting in Florence, Italy, 9/2011

    2011年09月  

  • 48th Annual Meeting of Japan Society of Hepatology Travel Awarded, Tokyo, 2011

    2011   Japan Society of Hepatology  

  • The valedictorian (1st) student of a whole course 1995-2001 awarded from Hanoi Medical University (2001)

    2001   Hanoi Medical University  

  • Scholarship granted by Pfizer, Pfizer Inc (1998), Vietnam

    1998   Pfizer  

  • Japan MEXT scholarship awarded for PhD course in Osaka University (2002-2007)

    MEXT  

▼全件表示

学歴

  • 大阪大学   医学研究科   博士課程   卒業・修了

    2003年04月 - 2007年03月

  • ハノイ医科大学   学士課程   卒業・修了

    1995年09月 - 2001年08月

論文

  • Transcriptomics of a cytoglobin knockout mouse: Insights from hepatic stellate cells and brain.

    Porto E, De Backer J, Thuy LTT, Kawada N, Hankeln T

    Journal of inorganic biochemistry   250   112405 - 112405   2024年01月( ISSN:0162-0134

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    掲載種別:研究論文(学術雑誌)   国際・国内誌:国際誌  

    DOI: 10.1016/j.jinorgbio.2023.112405

    PubMed

  • Collaborating with AI in literature search-An important frontier.

    Enomoto M, Tseng CH, Hsu YC, Thuy LTT, Nguyen MH

    Hepatology communications   7 ( 12 )   2023年12月

     詳細を見る

    掲載種別:研究論文(学術雑誌)   国際・国内誌:国際誌  

    DOI: 10.1097/HC9.0000000000000336

    PubMed

  • Nitric Oxide Derived from Cytoglobin-Deficient Hepatic Stellate Cells Causes Suppression of Cytochrome c Oxidase Activity in Hepatocytes.

    Okina Y, Sato-Matsubara M, Kido Y, Urushima H, Daikoku A, Kadono C, Nakagama Y, Nitahara Y, Hoang TH, Thuy LTT, Matsubara T, Ohtani N, Ikeda K, Yoshizato K, Kawada N

    Antioxidants & redox signaling   38 ( 7-9 )   463 - 479   2023年03月( ISSN:1523-0864

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    掲載種別:研究論文(学術雑誌)   国際・国内誌:国際誌  

    DOI: 10.1089/ars.2021.0279

    PubMed

  • Global treatment rate and barriers to direct-acting antiviral therapy: A systematic review and meta-analysis of 146 studies and 1 760 352 hepatitis C virus patients 査読 国際共著

    V. H. Nguyen; D. Q. Huang; M. H. Le; M. Jin; E. Y. Lee; L. Henry; S. N. Nerurkar; E. Ogawa; K. N. Thin; M. L. P. Teng; K. S. Goh; J. C. Y. Kai; C. Wong; D. J. H. Tan; L. T. T. Thuy; H. Hai; M. Enomoto; R. Cheung; M. H. Nguyen

    Liver International.   43   1195 - 1203   2023年02月

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    掲載種別:研究論文(学術雑誌)   国際・国内誌:国際誌  

  • In Vitro Models for the Study of Liver Biology and Diseases: Advances and Limitations. 招待 査読 国際共著

    Kaur S, Kidambi S, Ortega-Ribera M, Thuy LTT, Nieto N, Cogger VC, Xie WF, Tacke F, Gracia-Sancho J

    Cellular and molecular gastroenterology and hepatology   15 ( 3 )   559 - 571   2023年

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    担当区分:筆頭著者   掲載種別:研究論文(学術雑誌)   国際・国内誌:国際誌  

    DOI: 10.1016/j.jcmgh.2022.11.008

    PubMed

  • Soluble Immune Checkpoint Protein CD27 Is a Novel Prognostic Biomarker of Hepatocellular Carcinoma Development in Hepatitis C Virus-Sustained Virological Response Patients.

    Dong MP, Thuy LTT, Hoang DV, Hai H, Hoang TH, Sato-Matsubara M, Hieu VN, Daikoku A, Hanh NV, Urushima H, Dat NQ, Uchida-Kobayashi S, Enomoto M, Ohtani N, Tamori A, Kawada N

    The American journal of pathology   192 ( 10 )   1379 - 1396   2022年10月( ISSN:0002-9440

     詳細を見る

    掲載種別:研究論文(学術雑誌)   国際・国内誌:国際誌  

    DOI: 10.1016/j.ajpath.2022.07.003

    PubMed

  • Cancer cells produce liver metastasis via gap formation in sinusoidal endothelial cells through proinflammatory paracrine mechanisms.

    Huu Hoang T, Sato-Matsubara M, Yuasa H, Matsubara T, Thuy LTT, Ikenaga H, Phuong DM, Hanh NV, Hieu VN, Hoang DV, Hai H, Okina Y, Enomoto M, Tamori A, Daikoku A, Urushima H, Ikeda K, Dat NQ, Yasui Y, Shinkawa H, Kubo S, Yamagishi R, Ohtani N, Yoshizato K, Gracia-Sancho J, Kawada N

    Science advances   8 ( 39 )   eabo5525   2022年09月

     詳細を見る

    掲載種別:研究論文(学術雑誌)   国際・国内誌:国際誌  

    <jats:p>Intracellular gap (iGap) formation in liver sinusoidal endothelial cells (LSECs) is caused by the destruction of fenestrae and appears under pathological conditions; nevertheless, their role in metastasis of cancer cells to the liver remained unexplored. We elucidated that hepatotoxin-damaged and fibrotic livers gave rise to LSECs-iGap formation, which was positively correlated with increased numbers of metastatic liver foci after intrasplenic injection of Hepa1-6 cells. Hepa1-6 cells induced interleukin-23–dependent tumor necrosis factor–α (TNF-α) secretion by LSECs and triggered LSECs-iGap formation, toward which their processes protruded to transmigrate into the liver parenchyma. TNF-α triggered depolymerization of F-actin and induced matrix metalloproteinase 9 (MMP9), intracellular adhesion molecule 1, and CXCL expression in LSECs. Blocking MMP9 activity by doxycycline or an MMP2/9 inhibitor eliminated LSECs-iGap formation and attenuated liver metastasis of Hepa1-6 cells. Overall, this study revealed that cancer cells induced LSEC-iGap formation via proinflammatory paracrine mechanisms and proposed MMP9 as a favorable target for blocking cancer cell metastasis to the liver.</jats:p>

    DOI: 10.1126/sciadv.abo5525

    PubMed

  • Cancer cells produce liver metastasis via gap formation in sinusoidal endothelial cells 2 through pro-inflammatory paracrine mechanisms 査読

    9. Truong Huu Hoang, Misako Sato-Matsubara, Hideto Yuasa, Tsutomu Matsubara, Le Thi Thanh Thuy, Hiroko Ikenaga, Dong Minh Phuong, Ngo Vinh Hanh, Vu Ngoc Hieu, Dinh Viet Hoang, Hoang Hai, Yoshinori Okina, Masaru Enomoto, Akihiro Tamori, Atsuko Daikoku, Hayato Urushima, Kazuo Ikeda, Ninh Quoc Dat, Yutaka Yasui, Hiroji Shinkawa, Shoji Kubo, Ryota Yamagishi, Naoko Ohtani, Katsutoshi Yoshizato, Jordi Gracia-Sancho, Norifumi Kawada

    Science Advances   8 ( 39 )   eabo5525   2022年09月

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    掲載種別:研究論文(学術雑誌)   国際・国内誌:国際誌  

    DOI: 10.1126/sciadv.abo5525

  • Gasdermin D-mediated release of IL-33 from senescent hepatic stellate cells promotes obesity-associated hepatocellular carcinoma.

    Yamagishi R, Kamachi F, Nakamura M, Yamazaki S, Kamiya T, Takasugi M, Cheng Y, Nonaka Y, Yukawa-Muto Y, Thuy LTT, Harada Y, Arai T, Loo TM, Yoshimoto S, Ando T, Nakajima M, Taguchi H, Ishikawa T, Akiba H, Miyake S, Kubo M, Iwakura Y, Fukuda S, Chen WY, Kawada N, Rudensky A, Nakae S, Hara E, Ohtani N

    Science immunology   7 ( 72 )   eabl7209   2022年06月

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    掲載種別:研究論文(学術雑誌)   国際・国内誌:国際誌  

    DOI: 10.1126/sciimmunol.abl7209

    PubMed

  • Capacity of extracellular globins to reduce liver fibrosis via scavenging reactive oxygen species and promoting MMP-1 secretion.

    Hieu VN, Thuy LTT, Hai H, Dat NQ, Hoang DV, Hanh NV, Phuong DM, Hoang TH, Sawai H, Shiro Y, Sato-Matsubara M, Oikawa D, Tokunaga F, Yoshizato K, Kawada N

    Redox biology   52   102286 - 102286   2022年06月

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    掲載種別:研究論文(学術雑誌)   国際・国内誌:国際誌  

    DOI: 10.1016/j.redox.2022.102286

    PubMed

  • Cytoglobin attenuates pancreatic cancer growth via scavenging reactive oxygen species.

    Hoang DV, Thuy LTT, Hai H, Hieu VN, Kimura K, Oikawa D, Ikura Y, Dat NQ, Hoang TH, Sato-Matsubara M, Dong MP, Hanh NV, Uchida-Kobayashi S, Tokunaga F, Kubo S, Ohtani N, Yoshizato K, Kawada N

    Oncogenesis   11 ( 1 )   23 - 23   2022年05月( ISSN:2157-9024

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    掲載種別:研究論文(学術雑誌)   国際・国内誌:国際誌  

    DOI: 10.1038/s41389-022-00389-4

    PubMed

  • Soluble programmed cell death-1 predicts hepatocellular carcinoma development during nucleoside analogue treatment.

    Kozuka R, Enomoto M, Dong MP, Hai H, Thuy LTT, Odagiri N, Yoshida K, Kotani K, Motoyama H, Kawamura E, Hagihara A, Fujii H, Uchida-Kobayashi S, Tamori A, Kawada N

    Scientific reports   12 ( 1 )   105 - 105   2022年01月

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    掲載種別:研究論文(学術雑誌)   国際・国内誌:国際誌  

    DOI: 10.1038/s41598-021-03706-w

    PubMed

  • 膵星細胞に発現する サイトグロビンの膵癌 における役割 招待 査読

    消化器・肝臓内科    10 ( 3 )   354 - 362   2021年08月( ISSN:2432-3446

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    担当区分:筆頭著者   掲載種別:研究論文(学術雑誌)   国際・国内誌:国内誌  

  • Hexa Histidine-Tagged Recombinant Human Cytoglobin Deactivates Hepatic Stellate Cells and Inhibits Liver Fibrosis by Scavenging Reactive Oxygen Species.

    Dat NQ, Thuy LTT, Hieu VN, Hai H, Hoang DV, Thi Thanh Hai N, Thuy TTV, Komiya T, Rombouts K, Dong MP, Hanh NV, Hoang TH, Sato-Matsubara M, Daikoku A, Kadono C, Oikawa D, Yoshizato K, Tokunaga F, Pinzani M, Kawada N

    Hepatology (Baltimore, Md.)   73 ( 6 )   2527 - 2545   2021年06月( ISSN:0270-9139

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    掲載種別:研究論文(学術雑誌)   国際・国内誌:国際誌  

    <jats:sec>
    <jats:title>Background and Aims</jats:title>
    <jats:p>Antifibrotic therapy remains an unmet medical need in human chronic liver disease. We report the antifibrotic properties of cytoglobin (CYGB), a respiratory protein expressed in hepatic stellate cells (HSCs), the main cell type involved in liver fibrosis.</jats:p>
    </jats:sec>
    <jats:sec>
    <jats:title>Approach and Results</jats:title>
    <jats:p>
    <jats:italic toggle="yes">Cygb</jats:italic>‐deficient mice that had bile duct ligation–induced liver cholestasis or choline‐deficient amino acid–defined diet–induced steatohepatitis significantly exacerbated liver damage, fibrosis, and reactive oxygen species (ROS) formation. All of these manifestations were attenuated in <jats:italic toggle="yes">Cygb</jats:italic>‐overexpressing mice. We produced hexa histidine–tagged recombinant human CYGB (His‐CYGB), traced its biodistribution, and assessed its function in HSCs or in mice with advanced liver cirrhosis using thioacetamide (TAA) or 3,5‐diethoxycarbonyl‐1,4‐dihydrocollidine (DDC). In cultured HSCs, extracellular His‐CYGB was endocytosed and accumulated in endosomes through a clathrin‐mediated pathway. His‐CYGB significantly impeded ROS formation spontaneously or in the presence of ROS inducers in HSCs, thus leading to the attenuation of collagen type 1 alpha 1 production and α‐smooth muscle actin expression. Replacement the iron center of the heme group with cobalt nullified the effect of His‐CYGB. In addition, His‐CYGB induced interferon‐β secretion by HSCs that partly contributed to its antifibrotic function. Momelotinib incompletely reversed the effect of His‐CYGB. Intravenously injected His‐CYGB markedly suppressed liver inflammation, fibrosis, and oxidative cell damage in mice administered TAA or DDC mice without adverse effects. RNA‐sequencing analysis revealed the down‐regulation of inflammation‐ and fibrosis‐related genes and the up‐regulation of antioxidant genes in both cell culture and liver tissues. The injected His‐CYGB predominantly localized to HSCs but not to macrophages, suggesting specific targeting effects. His‐CYGB exhibited no toxicity in chimeric mice with humanized livers.</jats:p>
    </jats:sec>
    <jats:sec>
    <jats:title>Conclusions</jats:title>
    <jats:p>His‐CYGB could have antifibrotic clinical applications for human chronic liver diseases.</jats:p>
    </jats:sec>

    DOI: 10.1002/hep.31752

    PubMed

  • Hepatocellular carcinoma incidence with tenofovir versus entecavir in chronic hepatitis B: a systematic review and meta-analysis.

    Tseng CH, Hsu YC, Chen TH, Ji F, Chen IS, Tsai YN, Hai H, Thuy LTT, Hosaka T, Sezaki H, Borghi JA, Cheung R, Enomoto M, Nguyen MH

    The lancet. Gastroenterology & hepatology   5 ( 12 )   1039 - 1052   2020年12月

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    掲載種別:研究論文(学術雑誌)   国際・国内誌:国際誌  

    DOI: 10.1016/S2468-1253(20)30249-1

    PubMed

  • TGF-β1-driven reduction of cytoglobin leads to oxidative DNA damage in stellate cells during non-alcoholic steatohepatitis.

    Okina Y, Sato-Matsubara M, Matsubara T, Daikoku A, Longato L, Rombouts K, Thanh Thuy LT, Ichikawa H, Minamiyama Y, Kadota M, Fujii H, Enomoto M, Ikeda K, Yoshizato K, Pinzani M, Kawada N

    Journal of hepatology   73 ( 4 )   882 - 895   2020年10月( ISSN:0168-8278

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    掲載種別:研究論文(学術雑誌)   国際・国内誌:国際誌  

    DOI: 10.1016/j.jhep.2020.03.051

    PubMed

  • Early Change in the Plasma Levels of Circulating Soluble Immune Checkpoint Proteins in Patients with Unresectable Hepatocellular Carcinoma Treated by Lenvatinib or Transcatheter Arterial Chemoembolization.

    Odagiri N, Hai H, Thuy LTT, Dong MP, Suoh M, Kotani K, Hagihara A, Uchida-Kobayashi S, Tamori A, Enomoto M, Kawada N

    Cancers   12 ( 8 )   2020年07月( ISSN:2072-6694

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    掲載種別:研究論文(学術雑誌)   国際・国内誌:国際誌  

    DOI: 10.3390/cancers12082045

    PubMed

  • Role of cytoglobin, a novel radical scavenger, in stellate cell activation and hepatic fibrosis.

    Thuy LTT, Hai H, Kawada N

    Clinical and molecular hepatology   26 ( 3 )   280 - 293   2020年07月( ISSN:2287-2728

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    掲載種別:研究論文(学術雑誌)   国際・国内誌:国際誌  

    DOI: 10.3350/cmh.2020.0037

    PubMed

  • The Antioxidative Role of Cytoglobin in Podocytes: Implications for a Role in Chronic Kidney Disease.

    Randi EB, Vervaet B, Tsachaki M, Porto E, Vermeylen S, Lindenmeyer MT, Thuy LTT, Cohen CD, Devuyst O, Kistler AD, Szabo C, Kawada N, Hankeln T, Odermatt A, Dewilde S, Wenger RH, Hoogewijs D

    Antioxidants & redox signaling   32 ( 16 )   1155 - 1171   2020年06月( ISSN:1523-0864

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    掲載種別:研究論文(学術雑誌)   国際・国内誌:国際誌  

    DOI: 10.1089/ars.2019.7868

    PubMed

  • Clinical significance of circulating soluble immune checkpoint proteins in sorafenib-treated patients with advanced hepatocellular carcinoma.

    Dong MP, Enomoto M, Thuy LTT, Hai H, Hieu VN, Hoang DV, Iida-Ueno A, Odagiri N, Amano-Teranishi Y, Hagihara A, Fujii H, Uchida-Kobayashi S, Tamori A, Kawada N

    Scientific reports   10 ( 1 )   3392 - 3392   2020年02月

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    掲載種別:研究論文(学術雑誌)   国際・国内誌:国際誌  

    DOI: 10.1038/s41598-020-60440-5

    PubMed

  • Selective overexpression of cytoglobin in stellate cells attenuates thioacetamide-induced liver fibrosis in mice.

    Thi Thanh Hai N, Thuy LTT, Shiota A, Kadono C, Daikoku A, Hoang DV, Dat NQ, Sato-Matsubara M, Yoshizato K, Kawada N

    Scientific reports   8 ( 1 )   17860 - 17860   2018年12月

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    掲載種別:研究論文(学術雑誌)   国際・国内誌:国際誌  

    DOI: 10.1038/s41598-018-36215-4

    PubMed

  • Changes in plasma interleukin-8 and tumor necrosis factor-α levels during the early treatment period as a predictor of the response to sorafenib in patients with unresectable hepatocellular carcinoma.

    Iida-Ueno A, Enomoto M, Uchida-Kobayashi S, Hagihara A, Teranishi Y, Fujii H, Morikawa H, Murakami Y, Tamori A, Thuy LTT, Kawada N

    Cancer chemotherapy and pharmacology   82 ( 5 )   857 - 864   2018年11月( ISSN:0344-5704

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    掲載種別:研究論文(学術雑誌)   国際・国内誌:国際誌  

    DOI: 10.1007/s00280-018-3681-x

    PubMed

  • Fibroblast growth factor 2 (FGF2) regulates cytoglobin expression and activation of human hepatic stellate cells via JNK signaling.

    Sato-Matsubara M, Matsubara T, Daikoku A, Okina Y, Longato L, Rombouts K, Thuy LTT, Adachi J, Tomonaga T, Ikeda K, Yoshizato K, Pinzani M, Kawada N

    The Journal of biological chemistry   292 ( 46 )   18961 - 18972   2017年11月( ISSN:0021-9258

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    掲載種別:研究論文(学術雑誌)   国際・国内誌:国際誌  

    DOI: 10.1074/jbc.M117.793794

    PubMed

  • The Hemoglobin Homolog Cytoglobin in Smooth Muscle Inhibits Apoptosis and Regulates Vascular Remodeling.

    Jourd'heuil FL, Xu H, Reilly T, McKellar K, El Alaoui C, Steppich J, Liu YF, Zhao W, Ginnan R, Conti D, Lopez-Soler R, Asif A, Keller RK, Schwarz JJ, Thanh Thuy LT, Kawada N, Long X, Singer HA, Jourd'heuil D

    Arteriosclerosis, thrombosis, and vascular biology   37 ( 10 )   1944 - 1955   2017年10月( ISSN:1079-5642

     詳細を見る

    掲載種別:研究論文(学術雑誌)   国際・国内誌:国際誌  

    <jats:sec><jats:title>Objective—</jats:title><jats:p>The role of hemoglobin and myoglobin in the cardiovascular system is well established, yet other globins in this context are poorly characterized. Here, we examined the expression and function of cytoglobin (CYGB) during vascular injury.</jats:p></jats:sec><jats:sec><jats:title>Approach and Results—</jats:title><jats:p>We characterized CYGB content in intact vessels and primary vascular smooth muscle (VSM) cells and used 2 different vascular injury models to examine the functional significance of CYGB in vivo. We found that CYGB was strongly expressed in medial arterial VSM and human veins. In vitro and in vivo studies indicated that CYGB was lost after VSM cell dedifferentiation. In the rat balloon angioplasty model, site-targeted delivery of adenovirus encoding shRNA specific for CYGB prevented its reexpression and decreased neointima formation. Similarly, 4 weeks after complete ligation of the left common carotid,<jats:italic>Cygb</jats:italic>knockout mice displayed little to no evidence of neointimal hyperplasia in contrast to their wild-type littermates. Mechanistic studies in the rat indicated that this was primarily associated with increased medial cell loss, terminal uridine nick-end labeling staining, and caspase-3 activation, all indicative of prolonged apoptosis. In vitro, CYGB could be reexpressed after VSM stimulation with cytokines and hypoxia and loss of CYGB sensitized human and rat aortic VSM cells to apoptosis. This was reversed after antioxidant treatment or NOS2 (nitric oxide synthase 2) inhibition.</jats:p></jats:sec><jats:sec><jats:title>Conclusions—</jats:title><jats:p>These results indicate that CYGB is expressed in vessels primarily in differentiated medial VSM cells where it regulates neointima formation and inhibits apoptosis after injury.</jats:p></jats:sec>

    DOI: 10.1161/ATVBAHA.117.309410

    PubMed

  • Polymorphisms in MICA, but not in DEPDC5, HCP5 or PNPLA3, are associated with chronic hepatitis C-related hepatocellular carcinoma.

    Hai H, Tamori A, Thuy LTT, Yoshida K, Hagihara A, Kawamura E, Uchida-Kobayashi S, Morikawa H, Enomoto M, Murakami Y, Kawada N

    Scientific reports   7 ( 1 )   11912 - 11912   2017年09月

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    掲載種別:研究論文(学術雑誌)   国際・国内誌:国際誌  

    DOI: 10.1038/s41598-017-10363-5

    PubMed

  • Cytoglobin regulates blood pressure and vascular tone through nitric oxide metabolism in the vascular wall.

    Liu X, El-Mahdy MA, Boslett J, Varadharaj S, Hemann C, Abdelghany TM, Ismail RS, Little SC, Zhou D, Thuy LT, Kawada N, Zweier JL

    Nature communications   8   14807 - 14807   2017年04月

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    掲載種別:研究論文(学術雑誌)   国際・国内誌:国際誌  

    DOI: 10.1038/ncomms14807

    PubMed

  • Possible Involvement of Nitric Oxide in Enhanced Liver Injury and Fibrogenesis during Cholestasis in Cytoglobin-deficient Mice.

    Van Thuy TT, Thuy LT, Yoshizato K, Kawada N

    Scientific reports   7   41888 - 41888   2017年02月

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    掲載種別:研究論文(学術雑誌)   国際・国内誌:国際誌  

    DOI: 10.1038/srep41888

    PubMed

  • Absence of cytoglobin promotes multiple organ abnormalities in aged mice.

    Thuy le TT, Van Thuy TT, Matsumoto Y, Hai H, Ikura Y, Yoshizato K, Kawada N

    Scientific reports   6   24990 - 24990   2016年05月

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    掲載種別:研究論文(学術雑誌)   国際・国内誌:国際誌  

    DOI: 10.1038/srep24990

    PubMed

  • Pathophysiological role of cytoglobin, the fourth globin in mammals, in liver diseases.

    Thuy Le TT, Hai NT, Hai H, Kawada N

    Histology and histopathology   31 ( 3 )   257 - 67   2016年03月( ISSN:0213-3911

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  • Discovery of cytoglobin and its roles in physiology and pathology of hepatic stellate cells.

    Katsutoshi Yoshizato, Le Thi Thanh Thuy, Goshi Shiota, Norifumi Kawada

    Proceedings of the Japan Academy. Series B, Physical and biological sciences   92 ( 3 )   77 - 97   2016年

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    掲載種別:研究論文(学術雑誌)   国際・国内誌:国内誌  

    Cytoglobin (CYGB), a new member of the globin family, was discovered in 2001 as a protein associated with stellate cell activation (stellate cell activation-associated protein [STAP]). Knowledge of CYGB, including its crystal, gene, and protein structures as well as its physiological and pathological importance, has increased progressively. We investigated the roles of oxygen (O2)-binding CYGB as STAP in hepatic stellate cells (HSCs) to understand the part played by this protein in their pathophysiological activities. Studies involving CYGB-gene-deleted mice have led us to suppose that CYGB functions as a regulator of O2 homeostasis; when O2 homeostasis is disrupted, HSCs are activated and play a key role(s) in hepatic fibrogenesis. In this review, we discuss the rationale for this hypothesis.

    DOI: 10.2183/pjab.92.77

    PubMed

  • Cytoglobin deficiency promotes liver cancer development from hepatosteatosis through activation of the oxidative stress pathway.

    Thuy le TT, Matsumoto Y, Thuy TT, Hai H, Suoh M, Urahara Y, Motoyama H, Fujii H, Tamori A, Kubo S, Takemura S, Morita T, Yoshizato K, Kawada N

    The American journal of pathology   185 ( 4 )   1045 - 60   2015年04月( ISSN:0002-9440

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    掲載種別:研究論文(学術雑誌)   国際・国内誌:国際誌  

    DOI: 10.1016/j.ajpath.2014.12.017

    PubMed

  • Cytoglobin is expressed in hepatic stellate cells, but not in myofibroblasts, in normal and fibrotic human liver.

    Motoyama H, Komiya T, Thuy le TT, Tamori A, Enomoto M, Morikawa H, Iwai S, Uchida-Kobayashi S, Fujii H, Hagihara A, Kawamura E, Murakami Y, Yoshizato K, Kawada N

    Laboratory investigation; a journal of technical methods and pathology   94 ( 2 )   192 - 207   2014年02月( ISSN:0023-6837

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    掲載種別:研究論文(学術雑誌)   国際・国内誌:国際誌  

    DOI: 10.1038/labinvest.2013.135

    PubMed

  • Relationship between inosine triphosphate genotype and outcome of extended therapy in hepatitis C virus patients with a late viral response to pegylated-interferon and ribavirin.

    Hai H, Tamori A, Enomoto M, Morikawa H, Uchida-Kobayashi S, Fujii H, Hagihara A, Kawamura E, Thuy le TT, Tanaka Y, Kawada N

    Journal of gastroenterology and hepatology   29 ( 1 )   201 - 7   2014年01月( ISSN:0815-9319

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    掲載種別:研究論文(学術雑誌)   国際・国内誌:国際誌  

    <jats:title>Abstract</jats:title><jats:sec><jats:title>Background and Aim</jats:title><jats:p>It is not yet clear which factors are associated with the outcome of 72‐week treatment with pegylated‐interferon and ribavirin (<jats:styled-content style="fixed-case">RBV</jats:styled-content>) in patients with chronic hepatitis <jats:styled-content style="fixed-case">C</jats:styled-content> virus (<jats:styled-content style="fixed-case">HCV</jats:styled-content>) infection.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>In 66 patients with <jats:styled-content style="fixed-case">HCV</jats:styled-content> genotype 1 who had a late viral response (<jats:styled-content style="fixed-case">LVR</jats:styled-content>) to 72‐week treatment of pegylated‐interferon and <jats:styled-content style="fixed-case">RBV</jats:styled-content>, we examined the factors that determined the outcome, including single nucleotide polymorphisms of interleukin‐28<jats:styled-content style="fixed-case">B</jats:styled-content> and inosine triphosphatase (<jats:styled-content style="fixed-case"><jats:italic>ITPA</jats:italic></jats:styled-content>) genes.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Thirty seven of 66 (56%) patients with <jats:styled-content style="fixed-case">LVR</jats:styled-content> achieved a sustained viral response (<jats:styled-content style="fixed-case">SVR</jats:styled-content>). The mean age of these 37 <jats:styled-content style="fixed-case">SVR</jats:styled-content> patients was 55, compared with 61 in 29 relapsed patients (<jats:italic>P</jats:italic> = 0.009). Twenty six of 54 (48%) patients with the <jats:styled-content style="fixed-case">CC</jats:styled-content> genotype and 11 of 12 (92%) with the <jats:styled-content style="fixed-case">CA</jats:styled-content>/<jats:styled-content style="fixed-case">AA</jats:styled-content> genotype of <jats:styled-content style="fixed-case"><jats:italic>ITPA</jats:italic></jats:styled-content> rs1127354 achieved <jats:styled-content style="fixed-case">SVR</jats:styled-content> (<jats:italic>P</jats:italic> = 0.006). The <jats:styled-content style="fixed-case">SVR</jats:styled-content> rates were 79%, 40%, 60%, and 33% in patients with undetectable <jats:styled-content style="fixed-case">HCV RNA</jats:styled-content> on weeks 16, 20, 24, and 28 or later, respectively (<jats:italic>P</jats:italic> = 0.014). Finally, serum <jats:styled-content style="fixed-case">RBV</jats:styled-content> concentration at week 44 of treatment was significantly higher in the <jats:styled-content style="fixed-case">SVR</jats:styled-content> group (2651 ng/mL) than in the relapse group (1989 ng/mL, <jats:italic>P</jats:italic> = 0.002). In contrast, the rate of the interleukin‐28<jats:styled-content style="fixed-case">B</jats:styled-content> genotype was not different between the groups. Multiple regression analysis showed that age < 60 years, <jats:styled-content style="fixed-case"><jats:italic>ITPA</jats:italic> CA</jats:styled-content>/<jats:styled-content style="fixed-case">AA</jats:styled-content> genotype, and serum <jats:styled-content style="fixed-case">RBV</jats:styled-content> concentration were significant independent predictive factors for <jats:styled-content style="fixed-case">SVR</jats:styled-content>.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>Our findings elucidated the association of four factors, including <jats:styled-content style="fixed-case"><jats:italic>ITPA</jats:italic></jats:styled-content> genotype, with the outcome of 72‐week treatment in <jats:styled-content style="fixed-case">LVR</jats:styled-content> patients.</jats:p></jats:sec>

    DOI: 10.1111/jgh.12376

    PubMed

  • A pregnant woman with acute hepatitis B in whom vertical transmission was prevented by tenofovir disoproxil fumarate.

    Tooyama M, Tamori A, Nakano A, Hai H, Thuy le TT, Enomoto M, Kawada N

    Clinical journal of gastroenterology   6 ( 2 )   173 - 6   2013年04月( ISSN:1865-7257

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    掲載種別:研究論文(学術雑誌)   国際・国内誌:国内誌  

    DOI: 10.1007/s12328-013-0370-5

    PubMed

  • Antifibrotic role of macrophage migration inhibitory factor: discovery of an unexpected function.

    Thuy le TT, Kawada N

    Hepatology (Baltimore, Md.)   55 ( 4 )   1295 - 7   2012年04月( ISSN:0270-9139

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    掲載種別:研究論文(学術雑誌)   国際・国内誌:国際誌  

    DOI: 10.1002/hep.25605

    PubMed

  • A point-prevalence study on healthcare-associated infections in Vietnam: public health implications.

    Truong Anh Thu, Nguyen Viet Hung, Nguyen Ngo Quang, Lennox K Archibald, Le Thi Thanh Thuy, Harun-Or-Rashid, Junichi Sakamoto

    Infection control and hospital epidemiology   32 ( 10 )   1039 - 41   2011年10月

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    掲載種別:研究論文(学術雑誌)   国際・国内誌:国際誌  

    During 2008, a point-prevalence survey of healthcare-associated infections (HAIs) was conducted in 36 Vietnamese hospitals. Of 7,571 inpatients, 590 (7.8%) had HAIs, including pneumonia (41.9%) and surgical-site infections (27.5%). Device use was a significant risk factor; gram-negative microorganisms predominated. A national reporting system needs to be established for monitoring HAIs and enhancing patient outcomes.

    DOI: 10.1086/661915

    PubMed

  • Promotion of liver and lung tumorigenesis in DEN-treated cytoglobin-deficient mice.

    Thuy le TT, Morita T, Yoshida K, Wakasa K, Iizuka M, Ogawa T, Mori M, Sekiya Y, Momen S, Motoyama H, Ikeda K, Yoshizato K, Kawada N

    The American journal of pathology   179 ( 2 )   1050 - 60   2011年08月( ISSN:0002-9440

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    掲載種別:研究論文(学術雑誌)   国際・国内誌:国際誌  

    DOI: 10.1016/j.ajpath.2011.05.006

    PubMed

  • Distribution of genotype/subtype and mutational spectra of the surface gene of hepatitis B virus circulating in Hanoi, Vietnam.

    Le Thi Thanh Thuy, Haruko Ryo, Le Van Phung, Katsumi Furitsu, Taisei Nomura

    Journal of medical virology   76 ( 2 )   161 - 9   2005年06月( ISSN:0146-6615

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    掲載種別:研究論文(学術雑誌)   国際・国内誌:国際誌  

    In order to ascertain the molecular epidemiological features and mutational spectra of hepatitis B virus (HBV) in Hanoi, Vietnam, direct sequencing of the 219-nucleotide fragment of the surface (S) gene of HBV from the sera of 40 patients mostly with chronic hepatitis were carried out. The samples were classified into genotypes by phylogenetic and genotype-specific analysis, and subtypes by the deduced amino acid sequences. The results showed that genotype B with ayw1 was predominant genotype/subtype (63%), followed by genotype C with adr (18%). The quasi-species nature of the HBV in the sera was observed in 24 of 40 samples examined. One sample (HN109) showed mixture of genotypes B and C. Among 26 amino acid substitutions, 16 were the variants and the remainders were mutations. In the "a" determinant region, three mutations with methionine to leucine (L) changes at the 133 amino acid residue were in the first loop and no mutations were in the second loop. A new mutation, threonine to methionine at 126 amino acid residue, was observed in one sample. In conclusion, the analysis of the S gene region of HBV showed that in Hanoi, genotype B with ayw1 was prevalent and the quasi-species nature of HBV was also common.

    PubMed

  • Microsatellite mutations show no increases in the children of the Chernobyl liquidators.

    Katsumi Furitsu, Haruko Ryo, Klaudiya G Yeliseeva, Le Thi Thanh Thuy, Hiroaki Kawabata, Evelina V Krupnova, Valentina D Trusova, Valery A Rzheutsky, Hiroo Nakajima, Nikolai Kartel, Taisei Nomura

    Mutation research   581 ( 1-2 )   69 - 82   2005年03月( ISSN:0027-5107

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    掲載種別:研究論文(学術雑誌)   国際・国内誌:国際誌  

    We performed a study on Belarusian "liquidators", exploring whether increase in the frequencies of germline mutations at microsatellite loci could be found in their progeny. The liquidators, mostly young males, were those involved (during 1986 and 1987) in clean-up operations in the radioactively contaminated area following the Chernobyl nuclear power plant accident in 1986. Many liquidators fathered children during the clean-up period and after the work had been terminated. The numbers of families studied were 64 (liquidators) and 66 (controls). A total of 72 loci (31 autosomal, one X-linked and 40 Y-linked) were used. DNA was isolated from peripheral blood lymphocytes and the microsatellite loci were amplified by the polymerase chain reaction with fluorescence-labelled primers. Mutations were detected as variations in the length of the loci. At the Y-linked loci, the mutation rates (expressed as number of mutations among the total number of loci for the individuals included) are 2.9 x 10(-3) (4/1392) and 2.1 x 10(-3) (3/1458) in the children of exposed and control parents, respectively. This difference is not statistically significant. At the autosomal loci, the corresponding estimates are 5.9 x 10(-3) (11/1862; exposed group) and 8.5 x 10(-3) (18/2108; control). Again, the difference is not significant. The possibility that the Belarusian population might have been unexpectedly exposed to some chemical contaminants in the environment appears unlikely in view of the finding that the spontaneous mutation rates at the same set of loci in several non-Belarusian populations were similar to those in Belarus. The estimated mean radiation dose to the liquidators was small, being about 39 mSv, and this might be one reason why no increases in mutation rates due to radiation could be found.

    PubMed

▼全件表示

書籍等出版物

  • The Evolving Landscape of Liver Cirrhosis Management. Chapter 15: Antifibrotic therapy for liver cirrhosis 査読

    1. Le Thi Thanh Thuy, Hoang Hai, Vu Ngoc Hieu, Ninh Quoc Dat, Dinh Viet Hoang, and Norifumi Kawada

    Springer Nature Singapore Pte Ltd  2019年  ( ISBN:978-981-13-7979-6

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    参加形態:ファーストオーサー

  • Liver Pathophysiology: Therapies and Antioxidants. Chapter 17. Role of Oxidative and Nitrosative Stress in Hepatic Fibrosis. 査読

    2. Le Thi Thanh Thuy, Tuong Thi Van Thuy, Hoang Hai, and Norifumi Kawada

    Elsevier publishing group  2016年 

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    参加形態:ファーストオーサー

  • Studies on Hepatic Disorders. Oxidative Stress in Applied Basic Research and Clinical Practice. Chapter 18: Antioxidant Approach to the Therapy of Chronic Liver Diseases 査読

    Le Thi Thanh Thuy, Hoang Hai, and Norifumi Kawada

    Springer International Publishing Switzerland  2015年 

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    参加形態:ファーストオーサー

MISC(その他記事)

  • In Vitro Models for the Study of Liver Biology and Diseases: Advances and Limitations 招待 査読 国際共著

    Kaur S*, Kidambi S*, Ortega-Ribera M*, Thuy LTT*, Nieto N, Cogger V, Xie WF, Frank Tacke, Gracia-Sancho J.

    Cellular and Molecular Gastroenterology and Hepatology   15   559 - 571   2022年

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    担当区分:筆頭著者   掲載種別:記事・総説・解説・論説等(学術雑誌)   国際・国内誌:国際誌  

  • Role of Cytoglobin, a Novel Radical Scavenger, in Stellate Cell Activation and Hepatic Fibrosis 招待 査読

    Thuy LTT, Hai H, and Kawada N

    Clin Mol Hepatol   26   280 - 293   2020年

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    担当区分:筆頭著者   掲載種別:記事・総説・解説・論説等(学術雑誌)   国際・国内誌:国際誌  

  • Pathophysiological role of cytoglobin, the fourth globin in mammals, in liver diseases 招待 査読

    Thuy le TT, Hai NT, Hai H, Kawada N

    Histol Histopathol   31   257 - 267   2016年

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    担当区分:筆頭著者   掲載種別:記事・総説・解説・論説等(学術雑誌)   国際・国内誌:国際誌  

  • Discovery of cytoglobin and its roles in physiology and pathology of hepatic stellate cells 招待 査読

    Yoshizato K, Thuy le TT, Shiota G, Kawada N

    Proc Jpn Acad Ser B Phys Biol Sci   2016年

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    掲載種別:記事・総説・解説・論説等(学術雑誌)  

  • Antifibrotic role of macrophage migration inhibitory factor: discovery of an unexpected function 招待 査読

    Thuy le TT, Kawada N

    Hepatology   55 ( 4 )   1295 - 1297   2012年04月

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    担当区分:筆頭著者   掲載種別:記事・総説・解説・論説等(学術雑誌)   国際・国内誌:国際誌  

講演・口頭発表等

  • Insight profiling of non-parenchymal cells in liver fibrosis progression and regression by single-cell RNA sequencing analysis

    Le Thi Thanh Thuy, Pham Minh Duc, Hoang Hai, Nguyen Thi Ha, Norifumi Kawada

    22nd International Symposium on Cells of Hepatic Sinusoid (ISCHS)  2024年04月 

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    会議種別:ポスター発表  

  • Metabolic-Associated Fatty Liver Disease-Clinical 招待 国際会議

    Le Thi Thanh Thuy as Chairman

    the Asian Pacific Association for the Study of the Liver  2024年03月 

  • Single-cell RNA sequencing analysis of non-parenchymal cells in liver fibrosis progression and regression

    Pham Minh Duc, Le Thi Thanh Thuy, Hoang Hai, Nguyen Thi Ha, Norifumi Kawada

    Asian Pacific Association for the Study of the Liver (APASL)  2024年03月 

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    会議種別:口頭発表(一般)  

  • . Cell-cell interaction of LSECs-HSCs in the microenvironment of Diethyl nitrosamine treated Cytoglobin Knock-out mice

    Nguyen Thi Ha, Le Thi Thanh Thuy, Hoang Hai, Pham Minh Duc, Ngo Vinh Hanh, Nguyen Van Khanh, Nguyen Tran, Quang Sang, Inoue Mana, Norifumi Kawada

    Asian Pacific Association for the Study of the Liver (APASL)  2024年03月 

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    会議種別:口頭発表(一般)  

  • Single-cell RNA sequencing analysis of non-parenchymal cells in liver fibrosis progression and regression 国内会議

    Pham Minh Duc, Le Thi Thanh Thuy, Hoang Hai, Nguyen Thi Ha and Norifumi Kawada

    37th Annual Meetings for Hepatic Sinusoidal Research Japan  2023年12月 

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    会議種別:口頭発表(一般)  

  • Characteristics of consultation contents of Vietnamese migrants receiving free health consultations in Tokyo and Osaka

    Sangnim Lee, Xuyen Thi Nguyen, Quy Pham Nguyen, Shori Takaoka, Tadashi Yamashita, Yusaku Kusaba, Nhan Huu Thanh Nguyen, Oanh Thi Hoang Nguyen, Phu Dao Ngoc, Tomoki Saito, Trang Nguyen, Vu Hoang, Le Thi Thanh Thuy, Ha Ngoc Nguyen, Daisuke Shiojiri, Masao Hashimoto, Jin Takasaki

    The Global Health Joint Conference  2023年11月 

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    会議種別:口頭発表(一般)  

  • Interaction between HSC and LSEC populations in the premalignant environment of DEN-treated Cytoglobin knock-out mice

    Nguyen Thi Ha, Le Thi Thanh Thuy, Pham Minh Duc, Ngo Vinh Hanh, Nguyen Van Khanh, Nguyen Tran, Quang Sang, Inoue Mana, Norifumi Kawada

    Asian Pacific Association for the Study of the Liver (APASL) STC Oncology  2023年10月 

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    会議種別:口頭発表(一般)  

  • The flow of the times - Towards the future 招待 国際会議

    Le Thi Thanh Thuy

    Vietnam Summit in Japan  2023年10月 

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    会議種別:シンポジウム・ワークショップ パネル(公募)  

  • The promising therapeutics of recombinant human cytoglobin against acetaminophen-induced liver injury

    Pham Minh Duc, Le Thi Thanh Thuy, Hoang Hai, Nguyen Thi Ha, Vu Ngoc Hieu, Norifumi Kawada

    The 3rd Japan Society of Hepatology International Liver Conference  2023年09月 

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    会議種別:口頭発表(一般)  

  • Role of Cytoglobin in Liver Fibrosis and Steatohepatitis 招待 国際会議

    Le Thi Thanh Thuy

    The 3rd Japan Society of Hepatology International Liver Conference   2023年09月 

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    会議種別:口頭発表(招待・特別)  

  • CD40 expression in liver cancer cells is upregulated by CD4+T cells through IFN gamma and ERK 1/2 pathway 国際会議

    Ngo Vinh Hanh, Le Thi Thanh Thuy, Hoang Hai, Vu Ngoc Hieu, Sawako Uchida-Kobayashi, Masaru Enomoto, Akihiro Tamori and Norifumi Kawada

    European Association for the Study of Liver Annual Congress (EASL)  2023年06月 

  • Therapeutic effect of recombinant human Cytoglobin against mouse liver fibrosis and stellate cell activation via ROS scavenger function and activation of JAK-STAT1 pathway 国際会議

    Norifumi Kawada, Pham Minh Duc, Le Thi Thanh Thuy, and Hoang Hai

    European Association for the Study of Liver Annual Congress (EASL),  2023年06月 

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    会議種別:ポスター発表  

  • Baseline sCD27, sCD28, and sCD40 levels - novel predictors of HCC development in HCV-SVR patients 国際会議

    Le Thi Thanh Thuy, Minh Phuong Dong, Hoang Hai, Sawako Uchida-Kobayashi, Masaru Enomoto, Akihiro Tamori and Norifumi Kawada

    Asian Pacific Association for the Study of the Liver (APASL)  2023年02月 

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    会議種別:口頭発表(一般)  

  • Interaction between CD4+T cells and tumor cells in hepatocellular carcinoma microenvironment 国内会議

    Ngo Vinh Hanh, Le Thi Thanh Thuy, Hoang Hai, Vu Ngoc Hieu, Sawako Uchida-Kobayashi, Masaru Enomoto, Akihiro Tamori, and Norifumi Kawada

    35th Annual Meetings for Hepatic Sinusoidal Research Japan  2022年12月 

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    会議種別:口頭発表(一般)  

  • Extracellular Globin Therapy as a New Strategy to Combat Fibrotic Liver Diseases 招待 国際会議

    Le Thi Thanh Thuy

    The 10th Asian Biological Inorganic Chemistry Conference (AsBIC 10)   2022年11月 

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    会議種別:口頭発表(招待・特別)  

  • Soluble immune checkpoint protein CD27 is a novel prognostic predictor of HCC development in HCV-SVR patients 国際会議

    Le Thi Thanh Thuy, Minh Phuong Dong, Hoang Hai, Vu Ngoc Hieu, Dinh Viet Hoang, Sawako Uchida-Kobayashi, Masaru Enomoto, Akihiro Tamori and Norifumi Kawada

    Annual Meeting of American Association for the Study of Liver Diseases (AASLD)   2022年11月 

     詳細を見る

    会議種別:ポスター発表  

  • Anti-fibrotic Capacity of Extracellular Globins via Scavenging Reactive Oxygen Species 国際会議

    Le Thi Thanh Thuy, Vu Ngoc Hieu, Hoang Hai, and Norifumi Kawada

    XXI International Conference on Oxygen Binding and Sensing Proteins (O2BIP)   2022年09月 

     詳細を見る

    会議種別:口頭発表(一般)  

  • Endogenous and exogenous globin proteins presenting in Hepatic stellate cell suppress its activation and inhibit liver fibrosis via scavenging reactive oxygen species 国際会議

    Le Thi Thanh Thuy, Hoang Hai, and Norifumi Kawada

    21th International Symposium on Cells of Hepatic Sinusoid (ISCHS)  2022年09月 

     詳細を見る

    会議種別:口頭発表(一般)  

  • Cytoglobin, Neuroglobin, Myoglobin, but not Hemoglobin Exhibited Anti-Fibrotic Properties In Vitro and In Vivo 国内会議

    Le Thi Thanh Thuy, Vu Ngoc Hieu, Hoang Hai, Dinh Viet Hoang, and Norifumi Kawada

    The 58th Annual Meeting of the Japan Society of Hepatology  2022年06月 

     詳細を見る

    会議種別:口頭発表(一般)  

  • Novel Anti-Fibrotic Function of Neuroglobin in vitro and in vivo 国内会議

    Vu Ngoc Hieu, Le Thi Thanh Thuy, Hoang Hai, Dinh Viet Hoang, Ninh Quoc Dat, Katsutoshi Yoishizato and Norifumi Kawada

    35th Annual Meetings for Hepatic Sinusoidal Research Japan  2021年12月 

     詳細を見る

    会議種別:口頭発表(一般)  

  • Anti-fibrosis application of overexpression and recombinant human CYGB in multiple models of advanced fibrosis 国内会議

    Le Thi Thanh Thuy, Ninh Quoc Dat, Vu Ngoc Hieu, Hoang Hai, Dinh Viet Hoang, Katsutoshi Yoishizato and Norifumi Kawada

    The 29th Japan Gastroenterological Society Week   2021年11月 

     詳細を見る

    会議種別:口頭発表(一般)  

  • The way to the science of a Vietnamese doctor 招待 国内会議

    Le Thi Thanh Thuy

    Western Branch of The Japan Society of Hepatology  2019年12月 

     詳細を見る

    会議種別:口頭発表(招待・特別)  

  • Cytoglobin in Liver Biology 招待 国際会議

    Le Thi Thanh Thuy

    Osaka Metropolitan University International Liver Forum   2019年09月 

     詳細を見る

    会議種別:口頭発表(招待・特別)  

  • 門亢症の病態解明~基礎から臨床へ~ マウスにおいてサイトグロビンの欠損は散発性およびBDL誘発性肝障害を一酸化窒素の増加を介して促進する(Absence of Cytoglobin Promotes Spontaneous and BDL Induced Liver Injury in Mice via Increased Nitric Oxide)

    Le ThiThanhThuy, Hoang Hai, 吉里 勝利, 河田 則文

    日本門脈圧亢進症学会雑誌  2019年09月  (一社)日本門脈圧亢進症学会

  • Cytoglobin in Liver Injury and Fibrosis 招待 国際会議

    Le Thi Thanh Thuy

    Research Seminar in the Division of Gastroenterology and Hepatology and Liver Transplant Program at Stanford University Medical Center   2018年11月 

     詳細を見る

    会議種別:シンポジウム・ワークショップ パネル(指名)  

  • Role of Cytoglobin, the Fourth Globin in Mammals, in Liver Diseases 招待 国際会議

    Le Thi Thanh Thuy

    Vietnamese and Japanese Student Scientific Exchange Meeting  2016年09月 

     詳細を見る

    会議種別:口頭発表(招待・特別)  

  • Cytoglobin Prevents Fibrosis Development via Suppression of HSCs Activation and Inhibition of Oxidative Stress Pathway 招待 国内会議

    Le Thi Thanh Thuy

    Liver Forum in Kyoto   2016年03月 

     詳細を見る

    会議種別:口頭発表(招待・特別)  

  • Role of macrophage derived cytokines at the onset of steatohepatitis in Cytoglobin deficient mice 招待 国内会議

    Le Thi Thanh Thuy

    Liver Immunity Forum   2015年02月 

     詳細を見る

    会議種別:公開講演,セミナー,チュートリアル,講習,講義等  

▼全件表示

科研費

  • 慢性肝疾患において肝線維化が改善すると門脈圧は低下するか?その限界はどこか?

    基盤研究(C)  2023年04月

  • Novel anti-fibrotic properties of heme binding proteins including Neuroglobin, Myoglobin, and Hemoglobin in comparison with Cytoglobin in vitro and in vivo

    基盤研究(C)  2022年04月

  • 肝細胞のがん化における細胞間相互作用を介した星細胞の役割

    基盤研究(B)  2022年04月

  • Molecular understanding and therapy development of liver cirrhosis based on bioinformatics analysis of genes associated with hepatic microvascular cell-derived secretome.

    2022年04月

  • B型肝炎の治療抵抗性および病態進展における免疫チェックポイント分子の関与

    基盤研究(C)  2021年04月

  • Cytoglobin (CYGB)-overexpression and targeted demethylation of CYGB promoter impair liver and pancreatic tumor growth

    基盤研究(C)  2021年04月

  • 慢性肝疾患において肝線維化が改善すると門脈圧は低下するか?

    基盤研究(C)  2020年04月

  • Research on the development of therapeutic agent for anti-fibrosis using recombinant cytoglobin

    AMED  2019年04月

  • Cytoglobin overexpression inhibits liver fibrosis and cancer development via anti-oxidant function

    基盤研究(C)  2019年04月

  • Are activated stellate cells producing Cytoglobin directly involved in hepatocarcinogenesis?

    基盤研究(B)  2019年04月

  • Role of red blood cells and platelets in the development of chronic inflammation of nonalcoholic steatohepatitis

    基盤研究(C)  2017年04月

  • Improvement of liver function and prevention of liver carcinogenesis of liver cirrhosis by developing hepatic stellate cell deactivating agent

    AMED  2016年04月

  • Development of anti-fibrotic therapy for liver disease by establishing technologies that regulate cytoglobin expression in hepatic stellate cells

    基盤研究(B)  2016年04月

  • Protective role of CYGB in prevention of liver fibrosis development in vitro and in vivo

    若手研究(B)  2016年04月

  • Loss of Cytoglobin Exacerbates Liver Fibrosis and Cancer Development in Steatohepatitis by Activating the Oxidative Stress Pathaway

    若手研究(B)  2013年04月

  • Involvement of Cytoglobin expressed in hepatic stellate cells in the development of cancer derived from inflamed liver

    基盤研究(B)  2013年04月

  • Preventive and improvement of liver cirrhosis and cancer by de-activating HSCs

    Welfare and labor Science Research Grant for Hepatitis  2013年

  • Involvement of cytoglobin-expressing mesenchymal cells in cancer development

    挑戦的研究(開拓・萌芽)  2010年

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受託研究

  • Exploration of the novel role of Cytoglobin as a therapeutic approach for liver fibrosis and cancer

    Gilead Science Research Scholar Program   Exploration of the novel role of Cytoglobin as a therapeutic approach for liver fibrosis and cancer  2019年06月

担当教育概要

  • 全学のグローバル教育、COIL(Collaborative Online International Learning)型教育、留学生の受入、医学部医学英語
    (1) COIL プログラムは、本学の学生がグローバル化された世界で効果的に機能するために必要な知識、スキル、および態度を開発するのに役立ちます。全学におけるグローバル教育をけん引し、大学の世界展開力強化事業であるCOIL型教育(ICTを駆使して海外学生との地球規模のコミュニケーションにより、新しい観点や知識とより深い学びを得る教育方法)を促進していく。
    (2) 留学生の受入: 学生の受け入れを継続し、促進することは、OMU にとって非常に重要です。
    1) 学生人口の多様化を増やす
    2) 文化交流の促進
    3) 留学生の貢献による経済成長の促進
    4) 教育の目的地としての大学の世界的な評判を高める
    5) 将来の国際協力と外交の機会を創出します。
    (3) 医学部医学英語: COILプログラムに医学生専用の英語コースを設置; 医学研究推進コースの授業と修業実習。

担当授業科目

  • 2024後 ソーシャル・イノベーション研修: SIGLOC /S 【その他】

    2024年度   集中講義   大学

  • 2024前 ソーシャル・イノベーション研修: SIGLOC /S 【その他】

    2024年度   集中講義   大学

  • 2024後 ソーシャル・イノベーション研修: SIGLOC /S 【その他】

    2024年度   集中講義   大学

  • 2024後 国際協働演習: ICW /S 【水5】

    2024年度   週間授業   大学

  • 2024 医学研究推進コース1

    2024年度   週間授業   大学

  • 2024 医学研究推進コース3

    2024年度   実習   大学

  • ソーシャル・イノベーション研修: SIGLOC

    2023年度   集中講義   大学

  • ソーシャル・イノベーション研修: SIGLOC

    2023年度   集中講義   大学

  • 2022後 プログレッシブ・スピーキング 【金1】

    2022年度   週間授業   大学

▼全件表示

所属院生等の論文発表集計

  • 2024年度

    所属大学院生発表数:1件

  • 2022年度

    所属大学院生発表数:3件

  • 2021年度

    所属大学院生発表数:2件

  • 2019年度

    所属大学院生発表数:1件

  • 2017年度

    所属大学院生発表数:1件

  • 2015年度

    学部・学域生発表数:1件 

  • 2014年度

    学部・学域生発表数:1件 

▼全件表示

社会貢献活動

  • Meeting with the President of Vietnam at the Embassy of Vietnam in Tokyo

    役割:出演, インタビュアー

    Meeting with the President of Vietnam at the Embassy of Vietnam in Tokyo  2023年11月

     詳細を見る

    種別:対話型集会・市民会議

  • Meeting with the delegate of Bac Giang province at the General Consulate of Vietnam in Osaka

    役割:出演, 情報提供

    2023年04月

     詳細を見る

    種別:行政・教育機関等との連携事業

メディア報道

  • Special event celebrates decades of exchanges with Vietnam 会誌・広報誌

    OMU homepage  2024年03月

  • Bac Giang delegate visited OMU and Japan テレビ・ラジオ番組

    Bac Giang province TV news  Bac Giang delegate visited OMU and have signed MoU  2024年02月

  • Bac Giang delegate visited OMU and have signed MoU テレビ・ラジオ番組

    Bac Giang province TV news  Bac Giang delegate visited OMU and have signed MoU  2024年02月

  • Building a bridge of knowledge and collaboration: OMU holds joint seminar at Hanoi Medical University, Vietnam 会誌・広報誌

    OMU homepage  2023年10月

  • Vietnamese Consul General in Osaka pays courtesy visit to OMU 会誌・広報誌

    OMU homepage  2023年06月

  • Consul General of Vietnam in Osaka visits OMU and Graduate School of Medicine co-host a seminar with Vinmec 会誌・広報誌

    OMU homepage  2023年01月

  • OMU holds grand opening ceremony for Hanoi office 会誌・広報誌

    OMU homepage  2022年11月

  • OMU pays courtesy visit to VinUni, Vinmec, and Hanoi Medical University 会誌・広報誌

    OMU homepage  2022年07月

  • Vin大学、Vinmecとハノイ医科大学を表敬訪問 会誌・広報誌

    2022年07月

  • VinMec and VinUni established laboratory at OMU 会誌・広報誌

    VinUni and VinMec hospital homepage  2022年

▼全件表示

出張講義テーマ ⇒ 出張講義一覧へ

  • Ho Chi Minh days in Osaka on 2024/05/17 to 19

    分野:経済学, 理学(数学,物理学,化学,生物学,地球学,生物化学), 医学(医療,リハビリテーション,健康運動科学,体力・トレーニング,スポーツ実践科学)

     詳細を見る

    対象:研究者, 学術団体, 企業, 市民団体, 行政機関, メディア

    Participate in giving comments and proposing solutions to implement the Ho Chi Minh City's science and technology development programs and projects.

外国人受入実績

  • 2023年度

    留学生受入数 :1名

  • 2022年度

    留学生受入数 :5名

  • 2021年度

    留学生受入数 :1名

  • 2019年度

    留学生受入数 :1名

  • 2018年度

    留学生受入数 :2名

  • 2017年度

    留学生受入数 :2名

  • 2016年度

    留学生受入数 :1名

  • 2014年度

    留学生受入数 :1名

  • 2012年度

    留学生受入数 :1名

▼全件表示

国際交流活動

  • Exchange with Vietnam in the field of medicine at Osaka Metropolitan University
    1) The exchange with Vietnam in the field of medicine at Osaka Metropolitan University (Osaka City University) was promoted by Dr. Le Thi Thanh Thuy, who graduated from Hanoi Medical University with honors and completed a doctoral program as a MEXT government-sponsored student at the Graduate School of Medicine, Osaka University. It began in 2009 when Professor Norifumi Kawada hired her as a postdoctoral researcher in the Department of Hepatobiliary and Pancreatic Pathology at the Osaka City University Graduate School of Medicine.
    2) In October 2009, Dr. Le Thuy traveled to Hanoi, Vietnam, accompanied by Prof. Kawada, and met with leaders from the Ministry of Health of Vietnam, Hanoi Medical University, K Hospital (specializing in cancer treatment), and Nguyen Binh Kiem Central Traditional Medicine Hospital. Prof. Kawada realized that hepatitis B, liver fibrosis, and liver cancer have become major health problems in Vietnam. Since then, Prof. Kawada has expressed his desire to support the development of young researchers in Vietnam, the exchange of students and young doctors, and the transfer of advanced medical technology.
    3) Exchange with Hanoi Medical University: In particular, Dr. Ta Thanh Van, President of Hanoi Medical University, has studied abroad in Japan and has served as a postdoc under Professor Tasuku Honjo of Kyoto University, and is a pro-Japanese person. Hanoi Medical University and Osaka City University (OCU, now Osaka Metropolitan University) has signed MOU since 2012. As a result, by 2023, 9 students, mainly from Hanoi Medical University, have taken advantage of the MEXT Government Scholarship Program and 10 have enrolled in doctoral programs at Osaka Metropolitan University (Osaka City University) as privately financed international students, and 8 of them have obtained the degree of Doctor of Medicine. All of these students have been firstly selected by Dr. Thuy, introduced to Prof. Kawada. Dr. Thuy support them to PhD entry, mentor them during PhD course, and help them for both private life and scientific research. Due to these facts, Osaka Metropolitan University School of Medicine has the largest number of Vietnamese doctors and medical students in Japan. In 2022, Osaka Metropolitan University opened an office within Hanoi Medical University with the aim of promoting comprehensive and long-term cooperation with universities in Hanoi and Vietnam.
    In 2023, Dr. Le Thuy was appointed as an associate professor in the Department of Global Education and Medicine at the Graduate School of Medicine, Osaka Metropolitan University, where she will devote herself to international exchange with a focus on international education and medicine. For this reason, it is expected that there will be further personnel exchanges with Hanoi Medical University and Vietnam in the future.
    4) Exchange with 108 Hospital in Hanoi: On May 7, 2019, Prof. Norifumi Kawada, Dr. Le Thi Thanh Thuy and Dr. Hoang Hai visited the 108 Military Hospital. After a one-hour meeting to introduce each other and build a collaborative relationship in research, education, and medicine, we visited the hospital. Following this meeting, a memorandum of understanding was signed between Osaka City University School of Medicine (OCU) and 108 hospitals, which was signed in July 2019. Based on this, OCU trained two PhD students (Dr. Luu Viet Tien) and three young doctors in the Department of Radiology and Radiation Therapy from 108 hospitals for six months and were awarded certificates of completion. This year (2024), representatives of 108 hospitals are reportedly hoping to visit Osaka Metropolitan University (OMU) for the renewal of the memorandum of understanding and further cooperation in the future.
    5) Exchange with Saint Paul Hospital, Hanoi: Dr. Thuy has supported one invited Professor (Professor Tran Trung Dung) and other more than 20 young doctors from Saint Paul Hospital to visit OCU hospital for short-term training from 2 weeks to 3 months.
    6) Exchange with VinMec International Hospital and VinUni, Hanoi: Dr. Thuy, Professor Kawada and Professor Tran Trung Dung has started collaboration research at OMU which granted by VinMec International Hospital. The funding is 1,000,000 USD for 4 years from 2022/4 to 2026/12 with a PhD sandwich program for 4 young Vietnamese doctors. As a result, the VinMec Healthcare Innovation Laboratory was established in the Advanced Interdisciplinary Laboratory on the third basement floor of the OMU School of Medicine. Before, VinMec International Hospital and VinUni has started MoU with Osaka Metropolitan University (OMU) from 2021. From then, OMU's team and VinMec's team have conducted many seminars in both Hanoi and Osaka, and visit each other for promoting research activities.
    January 11, 2023: The 1st Vinmec Healthcare Innovation Science Seminar was held on the 12th floor of the seminar room of OMU School of Medicine.
    On September 29, 2023, the 2nd seminar "Innovation in Orthopedic Surgery and Rheumatology Symposium" was held at VinMec International Hospital in Hanoi, Vietnam.
    On December 18 and 19, 2023, a comprehensive medical checkup training program was held at VinMec International Hospital in Hanoi, Vietnam. The program was designed by Dr. Thuy, and funded by VinMec International Hospital. OMU's team included Prof. Kawada, Dr. Thuy, and other 3 doctors came to VinMec to give 9 lectures for this whole 2 days-course.
    On January 25 and 26, 2024, OMU's team including Prof. Kawada, Dr. Thuy, and Dr. Hoang Hai performed the public lectures on "liver diseases" and medical advice for the public at VinMec International Hospital in Hanoi, Vietnam.
    During the three visits to VinMec International Hospital in 2023-2024, CEO Le Thuy Anh asked if OMU doctors could regularly visit VinMec Hospital to provide medical advice. As a result, since Prof. Kawada and Associate Prof. Le Thuy are engaged in clinical and research on the liver, they suggested that we start by establishing a liver-related center, the VinMec-OMU Liver Center. Discussions are underway to obtain an agreement and establish a new structure.
    With regard to VinUni, OMU signed a Memorandum of Understanding (MoU) with VinMec and VinUni on December 25, 2021. This activity was reported on the VinUni website.
    OMU representatives, including Prof. Norifumi Kawada, Prof. Takashi Motomura, Dr. Le Thi Thanh Thuy, and Dr. Hoang Hai, visited VinUni and its 3D lab on November 14, 2022.
    On September 29, 2023, OMU professors Motomu Hashimoto, Hidetomi Terai, and Associate Professor Le Thi Thanh Thuy were appointed as faculty members of VinUni's Faculty of Global Studies for a two-year term from 2023 to 2025.

    7) Exchange activities with Bac Giang Province: Associate Professor Le Thuy met the president of Anh Quat Hospital in Bac Giang Province, and this led to the decision of Prof. Kawada and Associate Professor Sawako Uchida of the Department of Hepatobiliary and Pancreatic Pathology to give practical instruction on ultrasound (October 26-28, 2023).
    At the invitation of Mr. Mai Son, Deputy Governor of Bac Giang Province, OMU's team visited the Bac Giang Provincial Government Building and held talks. It was decided to sign a memorandum of understanding (MoU) with the commitment of Osaka Metropolitan University to support medicine and medical care. The meeting was reported in local newspapers and news programs. Deputy Governor Mai Son has a strong interest in collaborating with Osaka Metropolitan University, and a project has been planning to promote cooperation with hospitals in Bac Giang Province.
    8) With Vietnam National University School of Medicine: Thanks to the connection by Dr. Le Thuy, on September 27, 2023, an OMU delegation, including the President, Vice President, and 16 professors, visited the Faculty of Medicine of Vietnam National University. Subsequently, preparations for the signing of an MoU between the two universities began. On December 20, 2023, representatives of the Faculty of Medicine of Vietnam National University visited the OMU Graduate School of Medicine and signed a memorandum of understanding (MoU) to start cooperation. Currently, the two universities are building a joint online education program for both undergraduate and graduate students.
    9) With Vietnam Association of Private Hospitals: Dr. Nguyen Van De, director of Hop Luc General Hospital in Thanh Hoa Province and president of the Vietnam Private Medical Association, informed Prof. Le Thuy of his request to visit OMU and establish a cooperative relationship. Osaka Metropolitan University Hospital has accepted the proposal, and the Vietnam Private Physicians Association will visit us on June 12, 2024, with 25 Directors of private hospitals in Vietnam in attendance.



    活動区分 :教育

    活動国 :Vietnam   2009年10月 - 継続中