医学部 医学科

2024/06/04 更新
大学院医学研究科 臨床医科学専攻
准教授 2023年04月 - 継続中
医学部 医学科
准教授 2023年04月 - 継続中
博士(医学) ( 大阪大学 )
ライフサイエンス / 消化器内科学
ライフサイエンス / 消化器内科学
Cytoglobin, liver fibrosis, liver cancer, antioxidant, pancreatic cancer, bone cancer
1) Studying on molecular epidemiology of Hepatitis B Virus (HBV) which is one of the most serious viral hepatitis in Vietnam.
2)Investigating microsatellite loci as biomarkers indicating genetic alterations induced in the germ cells of Chernobyl clean-up workers that were transmitted to the children.
3) Examine the role of Cytoblogin in the pathophysiology of liver injuries, fibrosis, cirrhosis, and cancer, pancreatic cancer, and vascular diseases.
4) Investigating the affect of viral and host genetic factors to the diagnosis and treatment response in chronic hepatitis C/B patients.
5) Examining the role of immune checkpoint proteins in the development of liver cancer, hepatitis B/C.
6) Exploration of anti-fibrotic and anti-cancer therapies based on single cell RNA sequencing analysis.
Studying the molecular epidemiology of Hepatitis B Virus (HBV) which is one of the most serious viral hepatitis in Vietnam
個人研究
2002年10月 - 2005
Investigating microsatellite loci as biomarkers indicating genetic alterations induced in the germ cells of Chernobyl clean-up workers that were transmitted to the children
国内共同研究
2002年10月 - 2005
Examine the role of Cytoblogin in the pathophysiology of liver injuries, fibrosis, cirrhosis, and cancer, pancreatic cancer, and vascular diseases.
2009年01月 - 継続中
Investigating the affect of viral and host genetic factors to the diagnosis and treatment response in chronic hepatitis C/B patients
2017 - 継続中
Examining the role of immune checkpoint proteins in the development of liver cancer, hepatitis B/C.
2017 - 継続中
Exploration of anti-fibrotic and anti-cancer therapies based on single cell RNA sequencing analysis.
2020 - 継続中
American Association for the Study of Liver Diseases (AASLD)
The Japan Society of Gastroenterology (JSGE)
The Japan Society of Hepatology (JSH)
The Japan Society for Hepatic Sinusoidal Research (SHSR)
International Society for Hepatic Sinusoidal Research (ISHSR)
Poster award, 22nd International Symposium on Cells of Hepatic Sinusoid (ISCHS), Chicago, US, 4/2024
2024年04月
Young Investigator Award, 21st International Symposium on Cells of Hepatic Sinusoid (ISCHS), Shanghai, China, 9/2022
2022年09月 21st International Symposium on Cells of Hepatic Sinusoid (ISCHS)
APEC Science Leadership Program in Chiang Mai, Thailand, 8/2022
2022年08月
The Ichiro Kanehara Foundation Research Exchange Grant, 3/2022
2022年03月
Gilead Science Research Scholar Program in Liver Diseases Asia, 2/2019
2019年02月 Gilead Science Research Scholar Program
The Osaka Medical Research Foundation for Intractable Diseases Grant Award, 7/2016
2016年07月
The Japan Society of Hepatology (JSH) travel award for attending AASLD 2016 in Boston, USA
2016 Japan Society of Hepatology (JSH)
18th International Symposium on Cells of Hepatic Sinusoid (ISCHS) Travel Award, Asilomar, California, USA, 11/2015
2015年11月
Liver Forum in Kyoto Grant Award, 2015
2015年03月
Osaka City Medical Association Prize at Osaka City University, 12/2011
2011年12月
16th International Symposium on Cells of the Hepatic Sinusoid (ISCHS) Travel Awarded, Florence, Italy, 9/2011
2011年09月
Marco Foschi Prize for Research in GI Oncology at16th ISCHS meeting in Florence, Italy, 9/2011
2011年09月
48th Annual Meeting of Japan Society of Hepatology Travel Awarded, Tokyo, 2011
2011 Japan Society of Hepatology
The valedictorian (1st) student of a whole course 1995-2001 awarded from Hanoi Medical University (2001)
2001 Hanoi Medical University
Scholarship granted by Pfizer, Pfizer Inc (1998), Vietnam
1998 Pfizer
Japan MEXT scholarship awarded for PhD course in Osaka University (2002-2007)
MEXT
大阪大学 医学研究科 博士課程 卒業・修了
2003年04月 - 2007年03月
ハノイ医科大学 学士課程 卒業・修了
1995年09月 - 2001年08月
Transcriptomics of a cytoglobin knockout mouse: Insights from hepatic stellate cells and brain.
Porto E, De Backer J, Thuy LTT, Kawada N, Hankeln T
Journal of inorganic biochemistry 250 112405 - 112405 2024年01月( ISSN:0162-0134 )
Collaborating with AI in literature search-An important frontier.
Enomoto M, Tseng CH, Hsu YC, Thuy LTT, Nguyen MH
Hepatology communications 7 ( 12 ) 2023年12月
Okina Y, Sato-Matsubara M, Kido Y, Urushima H, Daikoku A, Kadono C, Nakagama Y, Nitahara Y, Hoang TH, Thuy LTT, Matsubara T, Ohtani N, Ikeda K, Yoshizato K, Kawada N
Antioxidants & redox signaling 38 ( 7-9 ) 463 - 479 2023年03月( ISSN:1523-0864 ) ( eISSN:15577716 )
Global treatment rate and barriers to direct-acting antiviral therapy: A systematic review and meta-analysis of 146 studies and 1 760 352 hepatitis C virus patients 査読 国際共著
V. H. Nguyen; D. Q. Huang; M. H. Le; M. Jin; E. Y. Lee; L. Henry; S. N. Nerurkar; E. Ogawa; K. N. Thin; M. L. P. Teng; K. S. Goh; J. C. Y. Kai; C. Wong; D. J. H. Tan; L. T. T. Thuy; H. Hai; M. Enomoto; R. Cheung; M. H. Nguyen
Liver International. 43 1195 - 1203 2023年02月
In Vitro Models for the Study of Liver Biology and Diseases: Advances and Limitations. 招待 査読 国際共著
Kaur S, Kidambi S, Ortega-Ribera M, Thuy LTT, Nieto N, Cogger VC, Xie WF, Tacke F, Gracia-Sancho J
Cellular and molecular gastroenterology and hepatology 15 ( 3 ) 559 - 571 2023年
Soluble Immune Checkpoint Protein CD27 Is a Novel Prognostic Biomarker of Hepatocellular Carcinoma Development in Hepatitis C Virus-Sustained Virological Response Patients.
Dong MP, Thuy LTT, Hoang DV, Hai H, Hoang TH, Sato-Matsubara M, Hieu VN, Daikoku A, Hanh NV, Urushima H, Dat NQ, Uchida-Kobayashi S, Enomoto M, Ohtani N, Tamori A, Kawada N
The American journal of pathology 192 ( 10 ) 1379 - 1396 2022年10月( ISSN:0002-9440 )
Huu Hoang T, Sato-Matsubara M, Yuasa H, Matsubara T, Thuy LTT, Ikenaga H, Phuong DM, Hanh NV, Hieu VN, Hoang DV, Hai H, Okina Y, Enomoto M, Tamori A, Daikoku A, Urushima H, Ikeda K, Dat NQ, Yasui Y, Shinkawa H, Kubo S, Yamagishi R, Ohtani N, Yoshizato K, Gracia-Sancho J, Kawada N
Science advances 8 ( 39 ) eabo5525 2022年09月( eISSN:23752548 )
Cancer cells produce liver metastasis via gap formation in sinusoidal endothelial cells 2 through pro-inflammatory paracrine mechanisms 査読
9. Truong Huu Hoang, Misako Sato-Matsubara, Hideto Yuasa, Tsutomu Matsubara, Le Thi Thanh Thuy, Hiroko Ikenaga, Dong Minh Phuong, Ngo Vinh Hanh, Vu Ngoc Hieu, Dinh Viet Hoang, Hoang Hai, Yoshinori Okina, Masaru Enomoto, Akihiro Tamori, Atsuko Daikoku, Hayato Urushima, Kazuo Ikeda, Ninh Quoc Dat, Yutaka Yasui, Hiroji Shinkawa, Shoji Kubo, Ryota Yamagishi, Naoko Ohtani, Katsutoshi Yoshizato, Jordi Gracia-Sancho, Norifumi Kawada
Science Advances 8 ( 39 ) eabo5525 2022年09月
Gasdermin D-mediated release of IL-33 from senescent hepatic stellate cells promotes obesity-associated hepatocellular carcinoma.
Yamagishi R, Kamachi F, Nakamura M, Yamazaki S, Kamiya T, Takasugi M, Cheng Y, Nonaka Y, Yukawa-Muto Y, Thuy LTT, Harada Y, Arai T, Loo TM, Yoshimoto S, Ando T, Nakajima M, Taguchi H, Ishikawa T, Akiba H, Miyake S, Kubo M, Iwakura Y, Fukuda S, Chen WY, Kawada N, Rudensky A, Nakae S, Hara E, Ohtani N
Science immunology 7 ( 72 ) eabl7209 2022年06月
Capacity of extracellular globins to reduce liver fibrosis via scavenging reactive oxygen species and promoting MMP-1 secretion.
Hieu VN, Thuy LTT, Hai H, Dat NQ, Hoang DV, Hanh NV, Phuong DM, Hoang TH, Sawai H, Shiro Y, Sato-Matsubara M, Oikawa D, Tokunaga F, Yoshizato K, Kawada N
Redox biology 52 102286 - 102286 2022年06月
Cytoglobin attenuates pancreatic cancer growth via scavenging reactive oxygen species.
Hoang DV, Thuy LTT, Hai H, Hieu VN, Kimura K, Oikawa D, Ikura Y, Dat NQ, Hoang TH, Sato-Matsubara M, Dong MP, Hanh NV, Uchida-Kobayashi S, Tokunaga F, Kubo S, Ohtani N, Yoshizato K, Kawada N
Oncogenesis 11 ( 1 ) 23 - 23 2022年05月( ISSN:2157-9024 )
Soluble programmed cell death-1 predicts hepatocellular carcinoma development during nucleoside analogue treatment.
Kozuka R, Enomoto M, Dong MP, Hai H, Thuy LTT, Odagiri N, Yoshida K, Kotani K, Motoyama H, Kawamura E, Hagihara A, Fujii H, Uchida-Kobayashi S, Tamori A, Kawada N
Scientific reports 12 ( 1 ) 105 - 105 2022年01月
膵星細胞に発現する サイトグロビンの膵癌 における役割 招待 査読
消化器・肝臓内科 10 ( 3 ) 354 - 362 2021年08月( ISSN:2432-3446 )
Dat NQ, Thuy LTT, Hieu VN, Hai H, Hoang DV, Thi Thanh Hai N, Thuy TTV, Komiya T, Rombouts K, Dong MP, Hanh NV, Hoang TH, Sato-Matsubara M, Daikoku A, Kadono C, Oikawa D, Yoshizato K, Tokunaga F, Pinzani M, Kawada N
Hepatology (Baltimore, Md.) 73 ( 6 ) 2527 - 2545 2021年06月( ISSN:0270-9139 ) ( eISSN:15273350 )
Hepatocellular carcinoma incidence with tenofovir versus entecavir in chronic hepatitis B: a systematic review and meta-analysis.
Tseng CH, Hsu YC, Chen TH, Ji F, Chen IS, Tsai YN, Hai H, Thuy LTT, Hosaka T, Sezaki H, Borghi JA, Cheung R, Enomoto M, Nguyen MH
The lancet. Gastroenterology & hepatology 5 ( 12 ) 1039 - 1052 2020年12月
TGF-β1-driven reduction of cytoglobin leads to oxidative DNA damage in stellate cells during non-alcoholic steatohepatitis.
Okina Y, Sato-Matsubara M, Matsubara T, Daikoku A, Longato L, Rombouts K, Thanh Thuy LT, Ichikawa H, Minamiyama Y, Kadota M, Fujii H, Enomoto M, Ikeda K, Yoshizato K, Pinzani M, Kawada N
Journal of hepatology 73 ( 4 ) 882 - 895 2020年10月( ISSN:0168-8278 )
Early Change in the Plasma Levels of Circulating Soluble Immune Checkpoint Proteins in Patients with Unresectable Hepatocellular Carcinoma Treated by Lenvatinib or Transcatheter Arterial Chemoembolization.
Odagiri N, Hai H, Thuy LTT, Dong MP, Suoh M, Kotani K, Hagihara A, Uchida-Kobayashi S, Tamori A, Enomoto M, Kawada N
Cancers 12 ( 8 ) 2020年07月( ISSN:2072-6694 )
Role of cytoglobin, a novel radical scavenger, in stellate cell activation and hepatic fibrosis.
Thuy LTT, Hai H, Kawada N
Clinical and molecular hepatology 26 ( 3 ) 280 - 293 2020年07月( ISSN:2287-2728 )
Randi EB, Vervaet B, Tsachaki M, Porto E, Vermeylen S, Lindenmeyer MT, Thuy LTT, Cohen CD, Devuyst O, Kistler AD, Szabo C, Kawada N, Hankeln T, Odermatt A, Dewilde S, Wenger RH, Hoogewijs D
Antioxidants & redox signaling 32 ( 16 ) 1155 - 1171 2020年06月( ISSN:1523-0864 ) ( eISSN:15577716 )
Clinical significance of circulating soluble immune checkpoint proteins in sorafenib-treated patients with advanced hepatocellular carcinoma.
Dong MP, Enomoto M, Thuy LTT, Hai H, Hieu VN, Hoang DV, Iida-Ueno A, Odagiri N, Amano-Teranishi Y, Hagihara A, Fujii H, Uchida-Kobayashi S, Tamori A, Kawada N
Scientific reports 10 ( 1 ) 3392 - 3392 2020年02月
Selective overexpression of cytoglobin in stellate cells attenuates thioacetamide-induced liver fibrosis in mice.
Thi Thanh Hai N, Thuy LTT, Shiota A, Kadono C, Daikoku A, Hoang DV, Dat NQ, Sato-Matsubara M, Yoshizato K, Kawada N
Scientific reports 8 ( 1 ) 17860 - 17860 2018年12月
Changes in plasma interleukin-8 and tumor necrosis factor-α levels during the early treatment period as a predictor of the response to sorafenib in patients with unresectable hepatocellular carcinoma.
Iida-Ueno A, Enomoto M, Uchida-Kobayashi S, Hagihara A, Teranishi Y, Fujii H, Morikawa H, Murakami Y, Tamori A, Thuy LTT, Kawada N
Cancer chemotherapy and pharmacology 82 ( 5 ) 857 - 864 2018年11月( ISSN:0344-5704 )
Fibroblast growth factor 2 (FGF2) regulates cytoglobin expression and activation of human hepatic stellate cells via JNK signaling.
Sato-Matsubara M, Matsubara T, Daikoku A, Okina Y, Longato L, Rombouts K, Thuy LTT, Adachi J, Tomonaga T, Ikeda K, Yoshizato K, Pinzani M, Kawada N
The Journal of biological chemistry 292 ( 46 ) 18961 - 18972 2017年11月( ISSN:0021-9258 )
Jourd'heuil FL, Xu H, Reilly T, McKellar K, El Alaoui C, Steppich J, Liu YF, Zhao W, Ginnan R, Conti D, Lopez-Soler R, Asif A, Keller RK, Schwarz JJ, Thanh Thuy LT, Kawada N, Long X, Singer HA, Jourd'heuil D
Arteriosclerosis, thrombosis, and vascular biology 37 ( 10 ) 1944 - 1955 2017年10月( ISSN:1079-5642 ) ( eISSN:15244636 )
Polymorphisms in MICA, but not in DEPDC5, HCP5 or PNPLA3, are associated with chronic hepatitis C-related hepatocellular carcinoma.
Hai H, Tamori A, Thuy LTT, Yoshida K, Hagihara A, Kawamura E, Uchida-Kobayashi S, Morikawa H, Enomoto M, Murakami Y, Kawada N
Scientific reports 7 ( 1 ) 11912 - 11912 2017年09月
Cytoglobin regulates blood pressure and vascular tone through nitric oxide metabolism in the vascular wall.
Liu X, El-Mahdy MA, Boslett J, Varadharaj S, Hemann C, Abdelghany TM, Ismail RS, Little SC, Zhou D, Thuy LT, Kawada N, Zweier JL
Nature communications 8 14807 - 14807 2017年04月
Possible Involvement of Nitric Oxide in Enhanced Liver Injury and Fibrogenesis during Cholestasis in Cytoglobin-deficient Mice.
Van Thuy TT, Thuy LT, Yoshizato K, Kawada N
Scientific reports 7 41888 - 41888 2017年02月
Absence of cytoglobin promotes multiple organ abnormalities in aged mice.
Thuy le TT, Van Thuy TT, Matsumoto Y, Hai H, Ikura Y, Yoshizato K, Kawada N
Scientific reports 6 24990 - 24990 2016年05月
Pathophysiological role of cytoglobin, the fourth globin in mammals, in liver diseases.
Thuy Le TT, Hai NT, Hai H, Kawada N
Histology and histopathology 31 ( 3 ) 257 - 67 2016年03月( ISSN:0213-3911 )
Discovery of cytoglobin and its roles in physiology and pathology of hepatic stellate cells.
Katsutoshi Yoshizato, Le Thi Thanh Thuy, Goshi Shiota, Norifumi Kawada
Proceedings of the Japan Academy. Series B, Physical and biological sciences 92 ( 3 ) 77 - 97 2016年
Cytoglobin deficiency promotes liver cancer development from hepatosteatosis through activation of the oxidative stress pathway.
Thuy le TT, Matsumoto Y, Thuy TT, Hai H, Suoh M, Urahara Y, Motoyama H, Fujii H, Tamori A, Kubo S, Takemura S, Morita T, Yoshizato K, Kawada N
The American journal of pathology 185 ( 4 ) 1045 - 60 2015年04月( ISSN:0002-9440 )
Cytoglobin is expressed in hepatic stellate cells, but not in myofibroblasts, in normal and fibrotic human liver.
Motoyama H, Komiya T, Thuy le TT, Tamori A, Enomoto M, Morikawa H, Iwai S, Uchida-Kobayashi S, Fujii H, Hagihara A, Kawamura E, Murakami Y, Yoshizato K, Kawada N
Laboratory investigation; a journal of technical methods and pathology 94 ( 2 ) 192 - 207 2014年02月( ISSN:0023-6837 )
Hai H, Tamori A, Enomoto M, Morikawa H, Uchida-Kobayashi S, Fujii H, Hagihara A, Kawamura E, Thuy le TT, Tanaka Y, Kawada N
Journal of gastroenterology and hepatology 29 ( 1 ) 201 - 7 2014年01月( ISSN:0815-9319 ) ( eISSN:14401746 )
A pregnant woman with acute hepatitis B in whom vertical transmission was prevented by tenofovir disoproxil fumarate.
Tooyama M, Tamori A, Nakano A, Hai H, Thuy le TT, Enomoto M, Kawada N
Clinical journal of gastroenterology 6 ( 2 ) 173 - 6 2013年04月( ISSN:1865-7257 )
Antifibrotic role of macrophage migration inhibitory factor: discovery of an unexpected function.
Thuy le TT, Kawada N
Hepatology (Baltimore, Md.) 55 ( 4 ) 1295 - 7 2012年04月( ISSN:0270-9139 )
A point-prevalence study on healthcare-associated infections in Vietnam: public health implications.
Truong Anh Thu, Nguyen Viet Hung, Nguyen Ngo Quang, Lennox K Archibald, Le Thi Thanh Thuy, Harun-Or-Rashid, Junichi Sakamoto
Infection control and hospital epidemiology 32 ( 10 ) 1039 - 41 2011年10月
Promotion of liver and lung tumorigenesis in DEN-treated cytoglobin-deficient mice.
Thuy le TT, Morita T, Yoshida K, Wakasa K, Iizuka M, Ogawa T, Mori M, Sekiya Y, Momen S, Motoyama H, Ikeda K, Yoshizato K, Kawada N
The American journal of pathology 179 ( 2 ) 1050 - 60 2011年08月( ISSN:0002-9440 )
Distribution of genotype/subtype and mutational spectra of the surface gene of hepatitis B virus circulating in Hanoi, Vietnam.
Le Thi Thanh Thuy, Haruko Ryo, Le Van Phung, Katsumi Furitsu, Taisei Nomura
Journal of medical virology 76 ( 2 ) 161 - 9 2005年06月( ISSN:0146-6615 )
Microsatellite mutations show no increases in the children of the Chernobyl liquidators.
Katsumi Furitsu, Haruko Ryo, Klaudiya G Yeliseeva, Le Thi Thanh Thuy, Hiroaki Kawabata, Evelina V Krupnova, Valentina D Trusova, Valery A Rzheutsky, Hiroo Nakajima, Nikolai Kartel, Taisei Nomura
Mutation research 581 ( 1-2 ) 69 - 82 2005年03月( ISSN:0027-5107 )
The Evolving Landscape of Liver Cirrhosis Management. Chapter 15: Antifibrotic therapy for liver cirrhosis 査読
1. Le Thi Thanh Thuy, Hoang Hai, Vu Ngoc Hieu, Ninh Quoc Dat, Dinh Viet Hoang, and Norifumi Kawada
Springer Nature Singapore Pte Ltd 2019年 ( ISBN:978-981-13-7979-6 )
Liver Pathophysiology: Therapies and Antioxidants. Chapter 17. Role of Oxidative and Nitrosative Stress in Hepatic Fibrosis. 査読
2. Le Thi Thanh Thuy, Tuong Thi Van Thuy, Hoang Hai, and Norifumi Kawada
Elsevier publishing group 2016年
Studies on Hepatic Disorders. Oxidative Stress in Applied Basic Research and Clinical Practice. Chapter 18: Antioxidant Approach to the Therapy of Chronic Liver Diseases 査読
Le Thi Thanh Thuy, Hoang Hai, and Norifumi Kawada
Springer International Publishing Switzerland 2015年
In Vitro Models for the Study of Liver Biology and Diseases: Advances and Limitations 招待 査読 国際共著
Kaur S*, Kidambi S*, Ortega-Ribera M*, Thuy LTT*, Nieto N, Cogger V, Xie WF, Frank Tacke, Gracia-Sancho J.
Cellular and Molecular Gastroenterology and Hepatology 15 559 - 571 2022年
Role of Cytoglobin, a Novel Radical Scavenger, in Stellate Cell Activation and Hepatic Fibrosis 招待 査読
Thuy LTT, Hai H, and Kawada N
Clin Mol Hepatol 26 280 - 293 2020年
Pathophysiological role of cytoglobin, the fourth globin in mammals, in liver diseases 招待 査読
Thuy le TT, Hai NT, Hai H, Kawada N
Histol Histopathol 31 257 - 267 2016年
Discovery of cytoglobin and its roles in physiology and pathology of hepatic stellate cells 招待 査読
Yoshizato K, Thuy le TT, Shiota G, Kawada N
Proc Jpn Acad Ser B Phys Biol Sci 2016年
Antifibrotic role of macrophage migration inhibitory factor: discovery of an unexpected function 招待 査読
Thuy le TT, Kawada N
Hepatology 55 ( 4 ) 1295 - 1297 2012年04月
Insight profiling of non-parenchymal cells in liver fibrosis progression and regression by single-cell RNA sequencing analysis
Le Thi Thanh Thuy, Pham Minh Duc, Hoang Hai, Nguyen Thi Ha, Norifumi Kawada
22nd International Symposium on Cells of Hepatic Sinusoid (ISCHS) 2024年04月
Metabolic-Associated Fatty Liver Disease-Clinical 招待 国際会議
Le Thi Thanh Thuy as Chairman
the Asian Pacific Association for the Study of the Liver 2024年03月
Single-cell RNA sequencing analysis of non-parenchymal cells in liver fibrosis progression and regression
Pham Minh Duc, Le Thi Thanh Thuy, Hoang Hai, Nguyen Thi Ha, Norifumi Kawada
Asian Pacific Association for the Study of the Liver (APASL) 2024年03月
. Cell-cell interaction of LSECs-HSCs in the microenvironment of Diethyl nitrosamine treated Cytoglobin Knock-out mice
Nguyen Thi Ha, Le Thi Thanh Thuy, Hoang Hai, Pham Minh Duc, Ngo Vinh Hanh, Nguyen Van Khanh, Nguyen Tran, Quang Sang, Inoue Mana, Norifumi Kawada
Asian Pacific Association for the Study of the Liver (APASL) 2024年03月
Single-cell RNA sequencing analysis of non-parenchymal cells in liver fibrosis progression and regression 国内会議
Pham Minh Duc, Le Thi Thanh Thuy, Hoang Hai, Nguyen Thi Ha and Norifumi Kawada
37th Annual Meetings for Hepatic Sinusoidal Research Japan 2023年12月
Characteristics of consultation contents of Vietnamese migrants receiving free health consultations in Tokyo and Osaka
Sangnim Lee, Xuyen Thi Nguyen, Quy Pham Nguyen, Shori Takaoka, Tadashi Yamashita, Yusaku Kusaba, Nhan Huu Thanh Nguyen, Oanh Thi Hoang Nguyen, Phu Dao Ngoc, Tomoki Saito, Trang Nguyen, Vu Hoang, Le Thi Thanh Thuy, Ha Ngoc Nguyen, Daisuke Shiojiri, Masao Hashimoto, Jin Takasaki
The Global Health Joint Conference 2023年11月
Interaction between HSC and LSEC populations in the premalignant environment of DEN-treated Cytoglobin knock-out mice
Nguyen Thi Ha, Le Thi Thanh Thuy, Pham Minh Duc, Ngo Vinh Hanh, Nguyen Van Khanh, Nguyen Tran, Quang Sang, Inoue Mana, Norifumi Kawada
Asian Pacific Association for the Study of the Liver (APASL) STC Oncology 2023年10月
The flow of the times - Towards the future 招待 国際会議
Le Thi Thanh Thuy
Vietnam Summit in Japan 2023年10月
The promising therapeutics of recombinant human cytoglobin against acetaminophen-induced liver injury
Pham Minh Duc, Le Thi Thanh Thuy, Hoang Hai, Nguyen Thi Ha, Vu Ngoc Hieu, Norifumi Kawada
The 3rd Japan Society of Hepatology International Liver Conference 2023年09月
Role of Cytoglobin in Liver Fibrosis and Steatohepatitis 招待 国際会議
Le Thi Thanh Thuy
The 3rd Japan Society of Hepatology International Liver Conference 2023年09月
CD40 expression in liver cancer cells is upregulated by CD4+T cells through IFN gamma and ERK 1/2 pathway 国際会議
Ngo Vinh Hanh, Le Thi Thanh Thuy, Hoang Hai, Vu Ngoc Hieu, Sawako Uchida-Kobayashi, Masaru Enomoto, Akihiro Tamori and Norifumi Kawada
European Association for the Study of Liver Annual Congress (EASL) 2023年06月
Therapeutic effect of recombinant human Cytoglobin against mouse liver fibrosis and stellate cell activation via ROS scavenger function and activation of JAK-STAT1 pathway 国際会議
Norifumi Kawada, Pham Minh Duc, Le Thi Thanh Thuy, and Hoang Hai
European Association for the Study of Liver Annual Congress (EASL), 2023年06月
Baseline sCD27, sCD28, and sCD40 levels - novel predictors of HCC development in HCV-SVR patients 国際会議
Le Thi Thanh Thuy, Minh Phuong Dong, Hoang Hai, Sawako Uchida-Kobayashi, Masaru Enomoto, Akihiro Tamori and Norifumi Kawada
Asian Pacific Association for the Study of the Liver (APASL) 2023年02月
Interaction between CD4+T cells and tumor cells in hepatocellular carcinoma microenvironment 国内会議
Ngo Vinh Hanh, Le Thi Thanh Thuy, Hoang Hai, Vu Ngoc Hieu, Sawako Uchida-Kobayashi, Masaru Enomoto, Akihiro Tamori, and Norifumi Kawada
35th Annual Meetings for Hepatic Sinusoidal Research Japan 2022年12月
Extracellular Globin Therapy as a New Strategy to Combat Fibrotic Liver Diseases 招待 国際会議
Le Thi Thanh Thuy
The 10th Asian Biological Inorganic Chemistry Conference (AsBIC 10) 2022年11月
Soluble immune checkpoint protein CD27 is a novel prognostic predictor of HCC development in HCV-SVR patients 国際会議
Le Thi Thanh Thuy, Minh Phuong Dong, Hoang Hai, Vu Ngoc Hieu, Dinh Viet Hoang, Sawako Uchida-Kobayashi, Masaru Enomoto, Akihiro Tamori and Norifumi Kawada
Annual Meeting of American Association for the Study of Liver Diseases (AASLD) 2022年11月
Anti-fibrotic Capacity of Extracellular Globins via Scavenging Reactive Oxygen Species 国際会議
Le Thi Thanh Thuy, Vu Ngoc Hieu, Hoang Hai, and Norifumi Kawada
XXI International Conference on Oxygen Binding and Sensing Proteins (O2BIP) 2022年09月
Endogenous and exogenous globin proteins presenting in Hepatic stellate cell suppress its activation and inhibit liver fibrosis via scavenging reactive oxygen species 国際会議
Le Thi Thanh Thuy, Hoang Hai, and Norifumi Kawada
21th International Symposium on Cells of Hepatic Sinusoid (ISCHS) 2022年09月
Cytoglobin, Neuroglobin, Myoglobin, but not Hemoglobin Exhibited Anti-Fibrotic Properties In Vitro and In Vivo 国内会議
Le Thi Thanh Thuy, Vu Ngoc Hieu, Hoang Hai, Dinh Viet Hoang, and Norifumi Kawada
The 58th Annual Meeting of the Japan Society of Hepatology 2022年06月
Novel Anti-Fibrotic Function of Neuroglobin in vitro and in vivo 国内会議
Vu Ngoc Hieu, Le Thi Thanh Thuy, Hoang Hai, Dinh Viet Hoang, Ninh Quoc Dat, Katsutoshi Yoishizato and Norifumi Kawada
35th Annual Meetings for Hepatic Sinusoidal Research Japan 2021年12月
Anti-fibrosis application of overexpression and recombinant human CYGB in multiple models of advanced fibrosis 国内会議
Le Thi Thanh Thuy, Ninh Quoc Dat, Vu Ngoc Hieu, Hoang Hai, Dinh Viet Hoang, Katsutoshi Yoishizato and Norifumi Kawada
The 29th Japan Gastroenterological Society Week 2021年11月
The way to the science of a Vietnamese doctor 招待 国内会議
Le Thi Thanh Thuy
Western Branch of The Japan Society of Hepatology 2019年12月
Cytoglobin in Liver Biology 招待 国際会議
Le Thi Thanh Thuy
Osaka Metropolitan University International Liver Forum 2019年09月
Le ThiThanhThuy, Hoang Hai, 吉里 勝利, 河田 則文
日本門脈圧亢進症学会雑誌 2019年09月 (一社)日本門脈圧亢進症学会
Cytoglobin in Liver Injury and Fibrosis 招待 国際会議
Le Thi Thanh Thuy
Research Seminar in the Division of Gastroenterology and Hepatology and Liver Transplant Program at Stanford University Medical Center 2018年11月
Role of Cytoglobin, the Fourth Globin in Mammals, in Liver Diseases 招待 国際会議
Le Thi Thanh Thuy
Vietnamese and Japanese Student Scientific Exchange Meeting 2016年09月
Cytoglobin Prevents Fibrosis Development via Suppression of HSCs Activation and Inhibition of Oxidative Stress Pathway 招待 国内会議
Le Thi Thanh Thuy
Liver Forum in Kyoto 2016年03月
Role of macrophage derived cytokines at the onset of steatohepatitis in Cytoglobin deficient mice 招待 国内会議
Le Thi Thanh Thuy
Liver Immunity Forum 2015年02月
慢性肝疾患において肝線維化が改善すると門脈圧は低下するか?その限界はどこか?
基盤研究(C) 2025年
Novel anti-fibrotic properties of heme binding proteins including Neuroglobin, Myoglobin, and Hemoglobin in comparison with Cytoglobin in vitro and in vivo
基盤研究(C) 2024年
肝細胞のがん化における細胞間相互作用を介した星細胞の役割
基盤研究(B) 2024年
慢性肝疾患において肝線維化が改善すると門脈圧は低下するか?その限界はどこか?
基盤研究(C) 2024年
慢性肝疾患において肝線維化が改善すると門脈圧は低下するか?その限界はどこか?
基盤研究(C) 2023年04月
Novel anti-fibrotic properties of heme binding proteins including Neuroglobin, Myoglobin, and Hemoglobin in comparison with Cytoglobin in vitro and in vivo
基盤研究(C) 2022年04月
肝細胞のがん化における細胞間相互作用を介した星細胞の役割
基盤研究(B) 2022年04月
Molecular understanding and therapy development of liver cirrhosis based on bioinformatics analysis of genes associated with hepatic microvascular cell-derived secretome.
2022年04月
B型肝炎の治療抵抗性および病態進展における免疫チェックポイント分子の関与
基盤研究(C) 2021年04月
Cytoglobin (CYGB)-overexpression and targeted demethylation of CYGB promoter impair liver and pancreatic tumor growth
基盤研究(C) 2021年04月
慢性肝疾患において肝線維化が改善すると門脈圧は低下するか?
基盤研究(C) 2020年04月
Research on the development of therapeutic agent for anti-fibrosis using recombinant cytoglobin
AMED 2019年04月
Cytoglobin overexpression inhibits liver fibrosis and cancer development via anti-oxidant function
基盤研究(C) 2019年04月
Are activated stellate cells producing Cytoglobin directly involved in hepatocarcinogenesis?
基盤研究(B) 2019年04月
Role of red blood cells and platelets in the development of chronic inflammation of nonalcoholic steatohepatitis
基盤研究(C) 2017年04月
Improvement of liver function and prevention of liver carcinogenesis of liver cirrhosis by developing hepatic stellate cell deactivating agent
AMED 2016年04月
Development of anti-fibrotic therapy for liver disease by establishing technologies that regulate cytoglobin expression in hepatic stellate cells
基盤研究(B) 2016年04月
Protective role of CYGB in prevention of liver fibrosis development in vitro and in vivo
若手研究(B) 2016年04月
Involvement of Cytoglobin expressed in hepatic stellate cells in the development of cancer derived from inflamed liver
基盤研究(B) 2013年04月
Loss of Cytoglobin Exacerbates Liver Fibrosis and Cancer Development in Steatohepatitis by Activating the Oxidative Stress Pathaway
若手研究(B) 2013年04月
Preventive and improvement of liver cirrhosis and cancer by de-activating HSCs
Welfare and labor Science Research Grant for Hepatitis 2013年
Involvement of cytoglobin-expressing mesenchymal cells in cancer development
挑戦的研究(開拓・萌芽) 2010年
Exploration of the novel role of Cytoglobin as a therapeutic approach for liver fibrosis and cancer
Gilead Science Research Scholar Program Exploration of the novel role of Cytoglobin as a therapeutic approach for liver fibrosis and cancer 2019年06月
全学のグローバル教育、COIL(Collaborative Online International Learning)型教育、留学生の受入、医学部医学英語
(1) COIL プログラムは、本学の学生がグローバル化された世界で効果的に機能するために必要な知識、スキル、および態度を開発するのに役立ちます。全学におけるグローバル教育をけん引し、大学の世界展開力強化事業であるCOIL型教育(ICTを駆使して海外学生との地球規模のコミュニケーションにより、新しい観点や知識とより深い学びを得る教育方法)を促進していく。
(2) 留学生の受入: 学生の受け入れを継続し、促進することは、OMU にとって非常に重要です。
1) 学生人口の多様化を増やす
2) 文化交流の促進
3) 留学生の貢献による経済成長の促進
4) 教育の目的地としての大学の世界的な評判を高める
5) 将来の国際協力と外交の機会を創出します。
(3) 医学部医学英語: COILプログラムに医学生専用の英語コースを設置; 医学研究推進コースの授業と修業実習。
グローバル教育と医学の応用実践: 英語で科学論文を書いて出版する方法
2024年度 大学院
シングルセルRNAシーケンシングセミナー:アプリケーション、サンプル調製、およびデータ分析
2024年度 大学院
抗線維化・抗がん治療セミナー
2024年度 大学院
組織線維化と発がんの病態生物学セミナー
2024年度 大学院
臨床医科学演習(グローバル教育・医療学)
2024年度 大学院
臨床医科学(グローバル教育・医療学)
2024年度 大学院
2024後 ソーシャル・イノベーション研修: SIGLOC /S 【その他】
2024年度 集中講義 大学
2024前 ソーシャル・イノベーション研修: SIGLOC /S 【その他】
2024年度 集中講義 大学
2024後 ソーシャル・イノベーション研修: SIGLOC /S 【その他】
2024年度 集中講義 大学
2024後 国際協働演習: ICW /S 【水5】
2024年度 週間授業 大学
2024 医学研究推進コース1
2024年度 週間授業 大学
2024 医学研究推進コース3
2024年度 実習 大学
ソーシャル・イノベーション研修: SIGLOC
2024年度 集中講義 大学院
ソーシャル・イノベーション研修: SIGLOC
2024年度 集中講義 大学院
ソーシャル・イノベーション研修: SIGLOC
2024年度 集中講義 大学院
国際協働演習: ICW
2024年度 週間授業 大学院
ソーシャル・イノベーション研修: SIGLOC
2023年度 集中講義 大学
ソーシャル・イノベーション研修: SIGLOC
2023年度 集中講義 大学
2022後 プログレッシブ・スピーキング 【金1】
2022年度 週間授業 大学
2024年度
所属大学院生発表数:1件
2022年度
所属大学院生発表数:3件
2021年度
所属大学院生発表数:2件
2019年度
所属大学院生発表数:1件
2017年度
所属大学院生発表数:1件
2015年度
学部・学域生発表数:1件
2014年度
学部・学域生発表数:1件
Meeting with the President of Vietnam at the Embassy of Vietnam in Tokyo
役割:出演, インタビュアー
種別:対話型集会・市民会議
Meeting with the President of Vietnam at the Embassy of Vietnam in Tokyo 2023年11月
Meeting with the delegate of Bac Giang province at the General Consulate of Vietnam in Osaka
役割:出演, 情報提供
種別:行政・教育機関等との連携事業
2023年04月
Special event celebrates decades of exchanges with Vietnam 会誌・広報誌
OMU homepage 2024年03月
Bac Giang delegate visited OMU and Japan テレビ・ラジオ番組
Bac Giang province TV news Bac Giang delegate visited OMU and have signed MoU 2024年02月
Bac Giang delegate visited OMU and have signed MoU テレビ・ラジオ番組
Bac Giang province TV news Bac Giang delegate visited OMU and have signed MoU 2024年02月
Building a bridge of knowledge and collaboration: OMU holds joint seminar at Hanoi Medical University, Vietnam 会誌・広報誌
OMU homepage 2023年10月
Vietnamese Consul General in Osaka pays courtesy visit to OMU 会誌・広報誌
OMU homepage 2023年06月
Consul General of Vietnam in Osaka visits OMU and Graduate School of Medicine co-host a seminar with Vinmec 会誌・広報誌
OMU homepage 2023年01月
OMU holds grand opening ceremony for Hanoi office 会誌・広報誌
OMU homepage 2022年11月
OMU pays courtesy visit to VinUni, Vinmec, and Hanoi Medical University 会誌・広報誌
OMU homepage 2022年07月
Vin大学、Vinmecとハノイ医科大学を表敬訪問 会誌・広報誌
2022年07月
VinMec and VinUni established laboratory at OMU 会誌・広報誌
VinUni and VinMec hospital homepage 2022年
Ho Chi Minh days in Osaka on 2024/05/17 to 19
分野:経済学, 理学(数学,物理学,化学,生物学,地球学,生物化学), 医学(医療,リハビリテーション,健康運動科学,体力・トレーニング,スポーツ実践科学)
2023年度
留学生受入数 :1名
2022年度
留学生受入数 :5名
2021年度
留学生受入数 :1名
2019年度
留学生受入数 :1名
2018年度
留学生受入数 :2名
2017年度
留学生受入数 :2名
2016年度
留学生受入数 :1名
2014年度
留学生受入数 :1名
2012年度
留学生受入数 :1名
Exchange with Vietnam in the field of medicine at Osaka Metropolitan University
1) The exchange with Vietnam in the field of medicine at Osaka Metropolitan University (Osaka City University) was promoted by Dr. Le Thi Thanh Thuy, who graduated from Hanoi Medical University with honors and completed a doctoral program as a MEXT government-sponsored student at the Graduate School of Medicine, Osaka University. It began in 2009 when Professor Norifumi Kawada hired her as a postdoctoral researcher in the Department of Hepatobiliary and Pancreatic Pathology at the Osaka City University Graduate School of Medicine.
2) In October 2009, Dr. Le Thuy traveled to Hanoi, Vietnam, accompanied by Prof. Kawada, and met with leaders from the Ministry of Health of Vietnam, Hanoi Medical University, K Hospital (specializing in cancer treatment), and Nguyen Binh Kiem Central Traditional Medicine Hospital. Prof. Kawada realized that hepatitis B, liver fibrosis, and liver cancer have become major health problems in Vietnam. Since then, Prof. Kawada has expressed his desire to support the development of young researchers in Vietnam, the exchange of students and young doctors, and the transfer of advanced medical technology.
3) Exchange with Hanoi Medical University: In particular, Dr. Ta Thanh Van, President of Hanoi Medical University, has studied abroad in Japan and has served as a postdoc under Professor Tasuku Honjo of Kyoto University, and is a pro-Japanese person. Hanoi Medical University and Osaka City University (OCU, now Osaka Metropolitan University) has signed MOU since 2012. As a result, by 2023, 9 students, mainly from Hanoi Medical University, have taken advantage of the MEXT Government Scholarship Program and 10 have enrolled in doctoral programs at Osaka Metropolitan University (Osaka City University) as privately financed international students, and 8 of them have obtained the degree of Doctor of Medicine. All of these students have been firstly selected by Dr. Thuy, introduced to Prof. Kawada. Dr. Thuy support them to PhD entry, mentor them during PhD course, and help them for both private life and scientific research. Due to these facts, Osaka Metropolitan University School of Medicine has the largest number of Vietnamese doctors and medical students in Japan. In 2022, Osaka Metropolitan University opened an office within Hanoi Medical University with the aim of promoting comprehensive and long-term cooperation with universities in Hanoi and Vietnam.
In 2023, Dr. Le Thuy was appointed as an associate professor in the Department of Global Education and Medicine at the Graduate School of Medicine, Osaka Metropolitan University, where she will devote herself to international exchange with a focus on international education and medicine. For this reason, it is expected that there will be further personnel exchanges with Hanoi Medical University and Vietnam in the future.
4) Exchange with 108 Hospital in Hanoi: On May 7, 2019, Prof. Norifumi Kawada, Dr. Le Thi Thanh Thuy and Dr. Hoang Hai visited the 108 Military Hospital. After a one-hour meeting to introduce each other and build a collaborative relationship in research, education, and medicine, we visited the hospital. Following this meeting, a memorandum of understanding was signed between Osaka City University School of Medicine (OCU) and 108 hospitals, which was signed in July 2019. Based on this, OCU trained two PhD students (Dr. Luu Viet Tien) and three young doctors in the Department of Radiology and Radiation Therapy from 108 hospitals for six months and were awarded certificates of completion. This year (2024), representatives of 108 hospitals are reportedly hoping to visit Osaka Metropolitan University (OMU) for the renewal of the memorandum of understanding and further cooperation in the future.
5) Exchange with Saint Paul Hospital, Hanoi: Dr. Thuy has supported one invited Professor (Professor Tran Trung Dung) and other more than 20 young doctors from Saint Paul Hospital to visit OCU hospital for short-term training from 2 weeks to 3 months.
6) Exchange with VinMec International Hospital and VinUni, Hanoi: Dr. Thuy, Professor Kawada and Professor Tran Trung Dung has started collaboration research at OMU which granted by VinMec International Hospital. The funding is 1,000,000 USD for 4 years from 2022/4 to 2026/12 with a PhD sandwich program for 4 young Vietnamese doctors. As a result, the VinMec Healthcare Innovation Laboratory was established in the Advanced Interdisciplinary Laboratory on the third basement floor of the OMU School of Medicine. Before, VinMec International Hospital and VinUni has started MoU with Osaka Metropolitan University (OMU) from 2021. From then, OMU's team and VinMec's team have conducted many seminars in both Hanoi and Osaka, and visit each other for promoting research activities.
January 11, 2023: The 1st Vinmec Healthcare Innovation Science Seminar was held on the 12th floor of the seminar room of OMU School of Medicine.
On September 29, 2023, the 2nd seminar "Innovation in Orthopedic Surgery and Rheumatology Symposium" was held at VinMec International Hospital in Hanoi, Vietnam.
On December 18 and 19, 2023, a comprehensive medical checkup training program was held at VinMec International Hospital in Hanoi, Vietnam. The program was designed by Dr. Thuy, and funded by VinMec International Hospital. OMU's team included Prof. Kawada, Dr. Thuy, and other 3 doctors came to VinMec to give 9 lectures for this whole 2 days-course.
On January 25 and 26, 2024, OMU's team including Prof. Kawada, Dr. Thuy, and Dr. Hoang Hai performed the public lectures on "liver diseases" and medical advice for the public at VinMec International Hospital in Hanoi, Vietnam.
During the three visits to VinMec International Hospital in 2023-2024, CEO Le Thuy Anh asked if OMU doctors could regularly visit VinMec Hospital to provide medical advice. As a result, since Prof. Kawada and Associate Prof. Le Thuy are engaged in clinical and research on the liver, they suggested that we start by establishing a liver-related center, the VinMec-OMU Liver Center. Discussions are underway to obtain an agreement and establish a new structure.
With regard to VinUni, OMU signed a Memorandum of Understanding (MoU) with VinMec and VinUni on December 25, 2021. This activity was reported on the VinUni website.
OMU representatives, including Prof. Norifumi Kawada, Prof. Takashi Motomura, Dr. Le Thi Thanh Thuy, and Dr. Hoang Hai, visited VinUni and its 3D lab on November 14, 2022.
On September 29, 2023, OMU professors Motomu Hashimoto, Hidetomi Terai, and Associate Professor Le Thi Thanh Thuy were appointed as faculty members of VinUni's Faculty of Global Studies for a two-year term from 2023 to 2025.
7) Exchange activities with Bac Giang Province: Associate Professor Le Thuy met the president of Anh Quat Hospital in Bac Giang Province, and this led to the decision of Prof. Kawada and Associate Professor Sawako Uchida of the Department of Hepatobiliary and Pancreatic Pathology to give practical instruction on ultrasound (October 26-28, 2023).
At the invitation of Mr. Mai Son, Deputy Governor of Bac Giang Province, OMU's team visited the Bac Giang Provincial Government Building and held talks. It was decided to sign a memorandum of understanding (MoU) with the commitment of Osaka Metropolitan University to support medicine and medical care. The meeting was reported in local newspapers and news programs. Deputy Governor Mai Son has a strong interest in collaborating with Osaka Metropolitan University, and a project has been planning to promote cooperation with hospitals in Bac Giang Province.
8) With Vietnam National University School of Medicine: Thanks to the connection by Dr. Le Thuy, on September 27, 2023, an OMU delegation, including the President, Vice President, and 16 professors, visited the Faculty of Medicine of Vietnam National University. Subsequently, preparations for the signing of an MoU between the two universities began. On December 20, 2023, representatives of the Faculty of Medicine of Vietnam National University visited the OMU Graduate School of Medicine and signed a memorandum of understanding (MoU) to start cooperation. Currently, the two universities are building a joint online education program for both undergraduate and graduate students.
9) With Vietnam Association of Private Hospitals: Dr. Nguyen Van De, director of Hop Luc General Hospital in Thanh Hoa Province and president of the Vietnam Private Medical Association, informed Prof. Le Thuy of his request to visit OMU and establish a cooperative relationship. Osaka Metropolitan University Hospital has accepted the proposal, and the Vietnam Private Physicians Association will visit us on June 12, 2024, with 25 Directors of private hospitals in Vietnam in attendance.
活動区分 :教育
活動国 :Vietnam 2009年10月 - 継続中