Updated on 2024/04/28

写真a

 
SHIBUTANI Masatsune
 
Organization
Graduate School of Medicine Department of Clinical Medical Science Lecturer
School of Medicine Department of Medical Science
Title
Lecturer
Affiliation
Institute of Medicine

Position

  • Graduate School of Medicine Department of Clinical Medical Science 

    Lecturer  2022.04 - Now

  • School of Medicine Department of Medical Science 

    Lecturer  2022.04 - Now

Degree

  • 博士(医学) ( Osaka City University )

Research Areas

  • Life Science / Digestive surgery

  • Life Science / Digestive surgery

Research Interests

  • 大腸癌

  • 化学療法

  • 栄養

  • 炎症

  • 免疫

  • 微小環境

  • 大腸癌

  • 化学療法

  • 免疫

  • 微小環境

  • 栄養

  • 炎症

Research subject summary

  • 大腸癌における癌微小環境、とりわけ癌局所免疫が癌の進行や治療抵抗性に及ぼす影響について研究を行っている。
    また、大腸癌における宿主因子、なかでも炎症・栄養・免疫が予後や治療効果に及ぼす影響について研究を行っている。

Research Career

  • Microenviroment of colorectal cancer

    Individual

    2012.04 - Now 

  • 大腸癌における炎症・栄養・免疫

    Individual

    2012.04 - Now 

Job Career (off-campus)

  • Osaka Metropolitan University School of Medicine Department of Medical Science

    2022.04 - Now

  • Osaka City University   Graduate School of Medicine Clinical Medicine Course

    2016.07 - Now

Education

  • Osaka City University     Graduated/Completed

Papers

  • Prognostic significance of connective tissue growth factor expression in stromal cells in patients with diffuse‑type gastric cancer.

    Miki Y, Yoshii M, Miyauchi R, Kasashima H, Fukuoka T, Tamura T, Shibutani M, Toyokawa T, Lee S, Yashiro M, Maeda K

    Oncology letters   27 ( 6 )   241   2024.06( ISSN:1792-1074

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  • D3 lymph node dissection using intracorporeal ultrasound for robotic right hemicolectomy - a video vignette.

    Fukuoka T, Kasashima H, Kitayama K, Iseki Y, Shibutani M, Maeda K

    Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland   2024.04( ISSN:1462-8910

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  • An 8-mm port site hernia after robotic-assisted ileocecal resection: a case report.

    Ahn C, Shibutani M, Kitayama K, Kasashima H, Miki Y, Yoshii M, Fukuoka T, Tamura T, Toyokawa T, Lee S, Maeda K

    Surgical case reports   10 ( 1 )   75   2024.04( ISSN:2198-7793

  • Large-scale animal model study uncovers altered brain pH and lactate levels as a transdiagnostic endophenotype of neuropsychiatric disorders involving cognitive impairment.

    Hagihara H, Shoji H, Hattori S, Sala G, Takamiya Y, Tanaka M, Ihara M, Shibutani M, Hatada I, Hori K, Hoshino M, Nakao A, Mori Y, Okabe S, Matsushita M, Urbach A, Katayama Y, Matsumoto A, Nakayama KI, Katori S, Sato T, Iwasato T, Nakamura H, Goshima Y, Raveau M, Tatsukawa T, Yamakawa K, Takahashi N, Kasai H, Inazawa J, Nobuhisa I, Kagawa T, Taga T, Darwish M, Nishizono H, Takao K, Sapkota K, Nakazawa K, Takagi T, Fujisawa H, Sugimura Y, Yamanishi K, Rajagopal L, Hannah ND, Meltzer HY, Yamamoto T, Wakatsuki S, Araki T, Tabuchi K, Numakawa T, Kunugi H, Huang FL, Hayata-Takano A, Hashimoto H, Tamada K, Takumi T, Kasahara T, Kato T, Graef IA, Crabtree GR, Asaoka N, Hatakama H, Kaneko S, Kohno T, Hattori M, Hoshiba Y, Miyake R, Obi-Nagata K, Hayashi-Takagi A, Becker LJ, Yalcin I, Hagino Y, Kotajima-Murakami H, Moriya Y, Ikeda K, Kim H, Kaang BK, Otabi H, Yoshida Y, Toyoda A, Komiyama NH, Grant SGN, Ida-Eto M, Narita M, Matsumoto KI, Okuda-Ashitaka E, Ohmori I, Shimada T, Yamagata K, Ageta H, Tsuchida K, Inokuchi K, Sassa T, Kihara A, Fukasawa M, Usuda N, Katano T, Tanaka T, Yoshihara Y, Igarashi M, Hayashi T, Ishikawa K, Yamamoto S, Nishimura N, Nakada K, Hirotsune S, Egawa K, Higashisaka K, Tsutsumi Y, Nishihara S, Sugo N, Yagi T, Ueno N, Yamamoto T, Kubo Y, Ohashi R, Shiina N, Shimizu K, Higo-Yamamoto S, Oishi K, Mori H, Furuse T, Tamura M, Shirakawa H, Sato DX, Inoue YU, Inoue T, Komine Y, Yamamori T, Sakimura K, Miyakawa T

    eLife   12   2024.03

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  • Effects of an artificial pancreas on postoperative inflammation in patients with esophageal cancer.

    Miyauchi R, Miki Y, Kasashima H, Fukuoka T, Yoshii M, Tamura T, Shibutani M, Toyokawa T, Lee S, Maeda K

    BMC surgery   24 ( 1 )   77   2024.03

  • Optimal extent of lymph node dissection for high-risk gastric cancer stratified by a national clinical database risk calculator.

    Kuroda K, Miki Y, Kasashima H, Yoshii M, Fukuoka T, Tamura T, Shibutani M, Toyokawa T, Lee S, Maeda K

    World journal of surgery   2024.02( ISSN:0364-2313

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  • The Effect of Bidirectional Barbed Sutures on the Duration of Common Enterotomy Closure in Intracorporeal Anastomosis.

    Shibutani M, Tanda H, Fukuoka T, Kasashima H, Maeda K

    In vivo (Athens, Greece)   38 ( 1 )   122 - 126   2024.01( ISSN:0258-851X

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  • Evaluation of Intraoperative Neural Monitoring During Thoracoscopic Surgery for Esophageal Cancer.

    Lee S, Fujiwara Y, Gyobu K, Tamura T, Toyokawa T, Miki Y, Yoshii M, Kasashiima H, Fukuoka T, Shibutani M, Osugi H, Maeda K

    Anticancer research   44 ( 1 )   157 - 166   2024.01( ISSN:0250-7005

  • An Improvement of Exertional Dyspnea by the Reintroduction of Anti-EGFR Antibody in Patients with Metastatic Rectal Cancer Who Developed Cancerous Lymphangiopathy: A Case Report.

    Shibutani M, Tanda H, Fukuoka T, Kasashima H, Kashiwagi S, Maeda K

    Case reports in oncology   17 ( 1 )   511 - 516   2024.01( ISSN:1662-6575

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  • Usefulness of intraoperative ultrasound examination for laparoscopic right-side colon cancer surgery: a propensity score-matched study.

    Kasashima H, Fukuoka T, Tsujio G, Sugimoto A, Yonemitsu K, Kitayama K, Iseki Y, Shibutani M, Maeda K

    Scientific reports   13 ( 1 )   22440   2023.12

  • Endoscopic Surgical Skill Qualification System: propensity-score matched cohort analysis of accredited supervisors in laparoscopic rectal cancer surgery

    Kiyozumi Y.

    British Journal of Surgery   110 ( 12 )   1834 - 1839   2023.12( ISSN:00071323

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  • A Case of Sigmoid Colon Cancer with Simultaneous Solitary Adrenal Metastasis Refractory to Preoperative Diagnosis

    Saito T.

    Gan to kagaku ryoho. Cancer & chemotherapy   50 ( 13 )   1557 - 1559   2023.12( ISSN:03850684

  • A Case of Robot-Assisted Abdominoperineal Resection Alongside En Bloc Prostatectomy and Vesico-Urethral Anastomosis for Local Recurrence

    Omori I.

    Gan to kagaku ryoho. Cancer & chemotherapy   50 ( 13 )   1482 - 1484   2023.12( ISSN:03850684

  • A Case of Late Recurrence of Anal Canal Carcinoma after Surgery, Discovered following the Diagnosis of a Subcutaneous Tumor in the Perineal Region

    Naito N.

    Gan to kagaku ryoho. Cancer & chemotherapy   50 ( 13 )   1495 - 1497   2023.12( ISSN:03850684

  • A Case of Advanced Recurrent Rectal Cancer Successfully Treated by Rechallenge Therapy with an Anti-Epidermal Growth Factor Receptor(EGFR)Drug

    Sakuma T.

    Gan to kagaku ryoho. Cancer & chemotherapy   50 ( 13 )   1504 - 1506   2023.12( ISSN:03850684

  • [A Case of Sigmoid Colon Cancer with Simultaneous Solitary Adrenal Metastasis Refractory to Preoperative Diagnosis].

    Saito T, Shibutani M, Fukuoka T, Kasashima H, Kitayama K, Tamura T, Toyokawa T, Ree S, Tanaka H, Kato M, Hirayama Y, Matsue T, Masuda K, Uchida J, Maeda K

    Gan to kagaku ryoho. Cancer & chemotherapy   50 ( 13 )   1557 - 1559   2023.12( ISSN:0385-0684

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  • [A Case of Robot-Assisted Abdominoperineal Resection Alongside En Bloc Prostatectomy and Vesico-Urethral Anastomosis for Local Recurrence].

    Omori I, Shibutani M, Fukuoka T, Kasashima H, Kitayama K, Miki Y, Yoshii M, Tamura T, Toyokawa T, Tanaka H, Lee S, Kato M, Yamazaki T, Uchida J, Maeda K

    Gan to kagaku ryoho. Cancer & chemotherapy   50 ( 13 )   1482 - 1484   2023.12( ISSN:0385-0684

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  • [A Case of Late Recurrence of Anal Canal Carcinoma after Surgery, Discovered following the Diagnosis of a Subcutaneous Tumor in the Perineal Region].

    Naito N, Shibutani M, Fukuoka T, Kasashima H, Miyamoto H, Nishi S, Deguchi S, Kitayama K, Miki Y, Yoshii M, Tamura T, Toyokawa T, Lee S, Tanaka H, Maeda K

    Gan to kagaku ryoho. Cancer & chemotherapy   50 ( 13 )   1495 - 1497   2023.12( ISSN:0385-0684

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  • [A Case of Advanced Recurrent Rectal Cancer Successfully Treated by Rechallenge Therapy with an Anti-Epidermal Growth Factor Receptor(EGFR)Drug].

    Sakuma T, Shibutani M, Fukuoka T, Kasashima H, Nishiyama M, Fukui Y, Natsuki S, Nishiyama T, Maruo K, Miki Y, Yoshii M, Tamura T, Toyokawa T, Lee S, Maeda K

    Gan to kagaku ryoho. Cancer & chemotherapy   50 ( 13 )   1504 - 1506   2023.12( ISSN:0385-0684

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  • Usefulness of Biopsy Specimens for Evaluating CD103(+) Tumor-resident Memory T Cells in Esophageal Cancer.

    Natsuki S, Miki Y, Tanaka H, Nishiyama M, Kasashima H, Fukuoka T, Yoshii M, Tamura T, Shibutani M, Toyokawa T, Lee S, Maeda K

    Anticancer research   43 ( 11 )   4823 - 4832   2023.11( ISSN:0250-7005

  • A Case of Straying of a Ventriculo-peritoneal Shunt Tube into the Intestinal Tract

    Naito Nobuhiro, Kitayama Kishu, Fukuoka Tatsunari, Sasaki Maho, Iseki Yasuhito, Kasashima Hiroaki, Shibutani Masatsune, Maeda Kiyoshi

    Nihon Fukubu Kyukyu Igakkai Zasshi (Journal of Abdominal Emergency Medicine)   43 ( 6 )   949 - 953   2023.09( ISSN:13402242

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    <p>The patient was a 39-year-old woman who had undergone ventriculo-peritoneal shunt implantation following surgery for multiple myeloma. She was brought to our hospital with a history of fever and impaired consciousness. Computed tomography (CT) of the head showed ventricular dilatation on the left side, and abdominal CT showed accidental migration of the ventriculo-peritoneal (VP) catheter into the small intestine. We performed ventricular drainage and examination of cerebrospinal fluid revealed signs of bacterial meningitis. We considered that the fever was due to meningitis caused by retrograde infection via the VP shunt. We treated the patient by removing the VP shunt tube on the ventricular side, fixing the VP shunt tube on the abdominal side to the abdominal wall, and creating a fistula. Two weeks later, after confirming that only the fistula was visible, the tube was removed. Perforation of the VP shunt tube through the gastrointestinal tract is a rare complication. In our case, exosomy was considered to be an effective treatment to avoid surgery under general anesthesia.</p>

    DOI: 10.11231/jaem.43.949

  • A case of a thoracic duct cyst extending from the mediastinum to the cisterna chyli resected using bilateral thoracoscopic surgery in the prone position.

    Miyamoto H, Lee S, Ishidate T, Kuroda K, Kasashima H, Miki Y, Yoshii M, Fukuoka T, Tamura T, Shibutani M, Toyokawa T, Maeda K

    Surgical case reports   9 ( 1 )   171   2023.09( ISSN:2198-7793

  • The Role of Cancer-Associated Fibroblasts in Modulating Tumor Immunity in Colorectal Cancer

    Kasashima H.

    Gan to kagaku ryoho. Cancer &amp; chemotherapy   50 ( 9 )   958 - 959   2023.09( ISSN:03850684

  • 腹臥位での両側胸腔鏡下で縦隔から乳糜槽へと拡大する胸管嚢胞を切除した1例(A case of a thoracic duct cyst extending from the mediastinum to the cisterna chyli resected using bilateral thoracoscopic surgery in the prone position)

    Miyamoto Hironari, Lee Shigeru, Ishidate Takemi, Kuroda Kenji, Kasashima Hiroaki, Miki Yuichiro, Yoshii Mami, Fukuoka Tatsunari, Tamura Tatsuro, Shibutani Masatsune, Toyokawa Takahiro, Maeda Kiyoshi

    Surgical Case Reports   9   1 of 8 - 8 of 8   2023.09

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    症例は77歳男性で、前立腺癌手術後の経過観察中に行われたCT検査で縦隔腫瘍を指摘され、当院紹介となった。造影CTで、第8胸椎から第2腰椎レベルで後縦隔から後腹膜腔にかけて連続した多病巣性嚢胞性病変が認められた。腫瘍の大きさは最大約20mmで、全体的に蛇行していたが、直線距離は約180mmで、内部に脂肪成分が多かった。MRIのT2強調像で高信号域が認められ、放射線学的に脂肪腫または高分化脂肪肉腫と診断した。腹臥位で行ったCTでは、重力によって胸腔が広がり、胸腔から腫瘍の尾側まで切除可能であったため、腹臥位で両側胸腔鏡下手術を行った。手術時間は4時間30分で、出血は少なかった。摘出標本は約20×180mmのsegmental tumorで、手術所見から脂肪腫ではなく胸管嚢胞が示唆された。病理組織学的検査では、線維性壁を持つ嚢胞構造と、嚢胞構造周囲にα-平滑筋アクチンで染色された平滑筋が認められ、胸管嚢胞と診断した。術後経過は良好で、術後4日目で退院した。術後13ヵ月時点のCTでは再発はみられなかった。

  • [The Role of Cancer-Associated Fibroblasts in Modulating Tumor Immunity in Colorectal Cancer].

    Kasashima H, Fukui Y, Kitayama K, Miki Y, Yoshii M, Fukuoka T, Tamura T, Shibutani M, Toyokawa T, Ree S, Tanaka H, Yashiro M, Maeda K

    Gan to kagaku ryoho. Cancer & chemotherapy   50 ( 9 )   958 - 959   2023.09( ISSN:0385-0684

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  • Impact of a circular powered stapler on preventing anastomotic leakage in patients with left-sided colorectal cancer: a retrospective study.

    Shibutani M, Fukuoka T, Iseki Y, Kasashima H, Kitayama K, Maeda K

    BMC surgery   23 ( 1 )   205   2023.07

  • Impact of Preoperative Nutritional Status on Long-term Survival in Patients With Stage I-III Colorectal Cancer.

    Shibutani M, Kashiwagi S, Fukuoka T, Iseki Y, Kasashima H, Maeda K

    In vivo (Athens, Greece)   37 ( 4 )   1765 - 1774   2023.07( ISSN:0258-851X

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  • Efficacy of the polyglycolic acid sheet for preventing anastomotic leakage in double-stapling technique anastomosis for left-sided colon or rectal cancer surgery: a propensity score-matched study.

    Shibutani M, Fukuoka T, Iseki Y, Kasashima H, Maeda K

    BMC surgery   23 ( 1 )   135   2023.05

  • Significance of the Prognostic Immune and Nutritional Index in Patients With Stage I-III Colorectal Cancer.

    Shibutani M, Kashiwagi S, Fukuoka T, Iseki Y, Kasashima H, Maeda K

    Cancer diagnosis & prognosis   3 ( 3 )   354 - 359   2023.05

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  • 連載 Medical Scope クローン病治療における内科と外科の連携

    福岡 達成, 北山 紀州, 笠島 裕明, 青松 直撥, 渋谷 雅常, 前田 清

    Pharma Medica   40 ( 1 )   46 - 49   2023.04( ISSN:02895803

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  • Prognostic significance of the Naples prognostic score in colorectal cancer patients undergoing curative resection: a propensity score matching analysis.

    Sugimoto A, Fukuoka T, Shibutani M, Kasashima H, Kitayama K, Ohira M, Maeda K

    BMC gastroenterology   23 ( 1 )   88   2023.03

  • Impact of oral statin therapy on clinical outcomes in patients with cT1 breast cancer.

    Takada K, Kashiwagi S, Iimori N, Kouhashi R, Yabumoto A, Goto W, Asano Y, Tauchi Y, Morisaki T, Ogisawa K, Shibutani M, Tanaka H, Maeda K

    BMC cancer   23 ( 1 )   224   2023.03

  • Predictive value of the Naples prognostic score on postoperative outcomes in patients with rectal cancer.

    Sugimoto A, Fukuoka T, Nagahara H, Shibutani M, Iseki Y, Kasashima H, Sasaki M, Ohira M, Maeda K

    Langenbeck's archives of surgery   408 ( 1 )   113   2023.03( ISSN:1435-2443

  • Eribulin Treatment Promotes Re-expression of Estrogen Receptor in Endocrine Therapy-resistant Hormone Receptor-positive Breast Cancer Cells.

    Goto W, Kashiwagi S, Iimori N, Kouhashi R, Yabumoto A, Takada K, Asano Y, Tauchi Y, Ogisawa K, Morisaki T, Shibutani M, Tanaka H, Maeda K

    Anticancer research   43 ( 2 )   603 - 611   2023.02( ISSN:0250-7005

  • Prognostic Impact of Smoking on Bevacizumab Combination Chemotherapy for Advanced Breast Cancer.

    Takada K, Kashiwagi S, Iimori N, Kouhashi R, Yabumoto A, Goto W, Asano Y, Tauchi Y, Ogisawa K, Morisaki T, Shibutani M, Tanaka H, Maeda K

    Anticancer research   43 ( 2 )   849 - 856   2023.02( ISSN:0250-7005

  • Clinical verification of the relationship between serum lipid metabolism and immune activity in breast cancer patients treated with neoadjuvant chemotherapy.

    Goto W, Kashiwagi S, Takada K, Asano Y, Ogisawa K, Morisaki T, Shibutani M, Tanaka H, Maeda K

    European journal of medical research   28 ( 1 )   2   2023.01( ISSN:0949-2321

  • Clinical Verification on the Predictors for Febrile Neutropenia in Breast Cancer Patients Treated With Neoadjuvant Chemotherapy.

    Goto W, Kashiwagi S, Matsuoka K, Iimori N, Kouhashi R, Yabumoto A, Takada K, Asano Y, Tauchi Y, Ogisawa K, Morisaki T, Shibutani M, Tanaka H, Maeda K

    Anticancer research   43 ( 1 )   247 - 254   2023.01( ISSN:0250-7005

  • The Significance of the D-Dimer Level as a Prognostic Marker for Survival and Treatment Outcomes in Patients With Stage IV Colorectal Cancer.

    Shibutani M, Kashiwagi S, Fukuoka T, Iseki Y, Kasashima H, Maeda K

    In vivo (Athens, Greece)   37 ( 1 )   440 - 444   2023.01( ISSN:0258-851X

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  • Prognostic Role of Preoperative D-dimer Levels in Patients With Stage I-III Colorectal Cancer.

    Shibutani M, Kashiwagi S, Fukuoka T, Iseki Y, Kasashima H, Kitayama K, Maeda K

    Cancer diagnosis & prognosis   3 ( 1 )   38 - 43   2023.01

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  • Factor Analysis of Intraoperative Bleeding Loss and its Impact on Prognosis in Breast Cancer.

    Takada K, Kashiwagi S, Iimori N, Kouhashi R, Yabumoto A, Goto W, Asano Y, Tauchi Y, Ogisawa K, Morisaki T, Shibutani M, Tanaka H, Maeda K

    Anticancer research   43 ( 1 )   191 - 200   2023.01( ISSN:0250-7005

  • Usefulness of the skeletal muscle index in postoperative ileus of colorectal cancer patients: a retrospective cohort study.

    Sasaki M, Fukuoka T, Shibutani M, Sugimoto A, Maeda K, Ohira M

    BMC surgery   22 ( 1 )   448   2022.12

  • A Case Report of Psoas Abscess Formation Caused by Mucinous Cystadenocarcinoma

    Nishi S.

    Gan to kagaku ryoho. Cancer &amp; chemotherapy   49 ( 8 )   897 - 899   2022.08( ISSN:03850684

  • 腸腰筋膿瘍を契機に発見された粘液性嚢胞腺癌の1例

    西 智史, 福岡 達成, 井関 康仁, 澁谷 雅常, 豊川 貴弘, 田中 浩明, 李 栄柱, 前田 清

    癌と化学療法   49 ( 8 )   897 - 899   2022.08( ISSN:0385-0684

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    症例は65歳、女性。約2ヵ月前からの立位困難感を主訴に、近医を受診した。腹部所見で右下腹部に腫瘤を指摘され、精査加療目的に当科紹介となった。来院時に著明な炎症反応上昇およびCT検査にて後腹膜から右腸腰筋内に連続する膿瘍形成を認めた。また、内視鏡検査でBauhin弁背側に潰瘍を認めた。術前診断は大腸穿通による腸腰筋膿瘍で治療難治性のため、大腸癌合併を考慮し手術を施行した。術中所見では盲腸背側に腫瘍性病変を認め腸腰筋と一塊となり、同部位に膿瘍を認めた。回盲部切除、D3リンパ節郭清を施行した。病理検査結果では盲腸粘液嚢胞腺癌で最終診断はpT4b、N0、M0、pStage IIcであった。術後経過は良好で、退院後に補助化学療法としてFOLFOX6療法を8サイクル施行した。術後1年8ヵ月現在、無再発生存している。腸腰筋膿瘍を合併する大腸癌は非常にまれな病態であり、若干の文献的考察を加え報告する。(著者抄録)

  • The Effect of Smoking on Endocrine Therapy for Stage IV Hormone Receptor Positive Breast Cancer.

    Takada K, Kashiwagi S, Kouhashi R, Iimori N, Yabumoto A, Goto W, Asano Y, Tauchi Y, Morisaki T, Shibutani M, Tanaka H, Ohira M

    Anticancer research   42 ( 8 )   3937 - 3946   2022.08( ISSN:0250-7005

  • [A Case Report of Psoas Abscess Formation Caused by Mucinous Cystadenocarcinoma].

    Nishi S, Fukuoka T, Iseki Y, Shibutani M, Toyokawa T, Tanaka H, Lee S, Maeda K

    Gan to kagaku ryoho. Cancer & chemotherapy   49 ( 8 )   897 - 899   2022.08( ISSN:0385-0684

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  • Validation of the Optimum Timing of Assessment of Tumor Infiltrating Lymphocytes During Preoperative Chemotherapy for Breast Cancer.

    Kashiwagi S, Asano Y, Takada K, Goto W, Kouhashi R, Yabumoto A, Tauchi Y, Morisaki T, Ogisawa K, Shibutani M, Tanaka H, Ohira M

    Cancer diagnosis & prognosis   2 ( 4 )   443 - 451   2022.07

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  • Development and evaluation of a colorectal cancer screening method using machine learning-based gut microbiota analysis.

    Konishi Y, Okumura S, Matsumoto T, Itatani Y, Nishiyama T, Okazaki Y, Shibutani M, Ohtani N, Nagahara H, Obama K, Ohira M, Sakai Y, Nagayama S, Hara E

    Cancer medicine   2022.03

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  • The impact of the surgical Apgar score on oncological outcomes in patients with colorectal cancer: a propensity score-matched study.

    Sugimoto A, Fukuoka T, Nagahara H, Shibutani M, Iseki Y, Sasaki M, Okazaki Y, Maeda K, Ohira M

    World journal of surgical oncology   20 ( 1 )   75   2022.03

  • Optical See-through Head-mounted Display (OST-HMD)-assisted Needle Biopsy for Breast Tumor: A Technical Innovation.

    Kashiwagi S, Asano Y, Goto W, Morisaki T, Shibutani M, Tanaka H, Hirakawa K, Ohira M

    In vivo (Athens, Greece)   36 ( 2 )   848 - 852   2022.03( ISSN:0258-851X

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  • Outcome Prediction After Neoadjuvant Chemotherapy (NAC) for Breast Cancer, Using Tumor-infiltrating Lymphocytes Within Fibrotic Foci of Tumor Stroma (FF-TILs).

    Kashiwagi S, Asano Y, Takada K, Goto W, Morisaki T, Shibutani M, Tanaka H, Hirakawa K, Ohira M

    Anticancer research   42 ( 3 )   1421 - 1431   2022.03( ISSN:0250-7005

  • Severe pancytopenia caused by trifluridine/tipiracil in patients with metastatic colorectal cancer and an impaired renal function: A case report.

    Shibutani M, Okazaki Y, Kashiwagi S, Nagahara H, Fukuoka T, Iseki Y, Maeda K, Hirakawa K, Ohira M

    Clinical case reports   10 ( 3 )   e05544   2022.03

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  • Differences in tumor-infiltrating lymphocyte density and prognostic factors for breast cancer by patient age.

    Takada K, Kashiwagi S, Asano Y, Goto W, Morisaki T, Shibutani M, Tanaka H, Hirakawa K, Ohira M

    World journal of surgical oncology   20 ( 1 )   38   2022.02

  • Utility of Follow-up With Absolute Lymphocyte Count in Patients Undergoing Eribulin Treatment for Early Detection of Progressive Advanced or Metastatic Breast Cancer.

    Goto W, Kashiwagi S, Takada K, Asano Y, Morisaki T, Shibutani M, Tanaka H, Hirakawa K, Ohira M

    Anticancer research   42 ( 2 )   939 - 946   2022.02( ISSN:0250-7005

  • 症例報告 重複下大静脈を伴う直腸癌に対してロボット支援下手術を施行した1例

    吉田 瑞樹, 福岡 達成, 永原 央, 渋谷 雅常, 井関 康仁, 大平 雅一

    日本内視鏡外科学会雑誌   27 ( 1 )   29 - 34   2022.01( ISSN:13446703

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  • Clinical Significance of Expression of Immunoadjuvant Molecules (LAG-3, TIM-3, OX-40) in Neoadjuvant Chemotherapy for Breast Cancer.

    Asano Y, Kashiwagi S, Takada K, Ishihara S, Goto W, Morisaki T, Shibutani M, Tanaka H, Hirakawa K, Ohira M

    Anticancer research   42 ( 1 )   125 - 136   2022.01( ISSN:0250-7005

  • The Effect of Smoking on Progression from Ductal Carcinoma <i>In Situ</i> to Invasive Ductal Breast Carcinoma: A Retrospective Study.

    Takada K, Kashiwagi S, Asano Y, Goto W, Morisaki T, Shibutani M, Tanaka H, Hirakawa K, Ohira M

    Anticancer research   42 ( 1 )   311 - 320   2022.01( ISSN:0250-7005

  • Significance of information obtained during transanal drainage tube placement after anterior resection of colorectal cancer.

    Okazaki Y, Shibutani M, Nagahara H, Fukuoka T, Iseki Y, Wang E, Maeda K, Hirakawa K, Ohira M

    PloS one   17 ( 8 )   e0271496   2022

  • Impact of the COVID-19 Pandemic on Patients with Gastrointestinal Cancer Undergoing Active Cancer Treatment in an Ambulatory Therapy Center: The Patients' Perspective.

    Taira K, Nagahara H, Tanaka H, Kimura A, Nakata A, Iseki Y, Fukuoka T, Shibutani M, Toyokawa T, Lee S, Muguruma K, Ohira M, Kawaguchi T, Fujiwara Y

    Healthcare (Basel, Switzerland)   9 ( 12 )   2021.12

  • A Case of Hyperammonemic Encephalopathy following mFOLFOX6 plus Panitumumab Therapy for Rectal Cancer

    Tsujio G.

    Gan to kagaku ryoho. Cancer &amp; chemotherapy   48 ( 13 )   2073 - 2075   2021.12( ISSN:03850684

  • A Case of Hyperammonemic Encephalopathy following mFOLFOX6 plus Panitumumab Therapy for Rectal Cancer

    Tsujio G

    Gan to kagaku ryoho. Cancer &amp; chemotherapy   48 ( 13 )   2073 - 2075   2021.12( ISSN:0385-0684

  • Prevention of anastomotic leakage using a polyglycolic acid sheet in double-stapling technique anastomosis for rectal surgery.

    Shibutani M, Nagahara H, Fukuoka T, Iseki Y, Okazaki Y, Hirakawa K, Ohira M

    Annals of medicine and surgery (2012)   72   103117   2021.12( ISSN:20490801

  • [A Fatal Case of Meningeal Carcinomatosis in a Rectal Cancer Patient Diagnosed with Pathologic Complete Response after Neoadjuvant Chemoradiotherapy].

    Yokomatsu H, Katsuragi K, Xiang Z, Shibutani M

    Gan to kagaku ryoho. Cancer & chemotherapy   48 ( 13 )   1673 - 1675   2021.12( ISSN:0385-0684

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  • [A Case of Hyperammonemic Encephalopathy following mFOLFOX6 plus Panitumumab Therapy for Rectal Cancer].

    Tsujio G, Muguruma K, Eguchi S, Iseki Y, Miki Y, Yoshii M, Fukuoka T, Tamura T, Shibutani M, Nagahara H, Toyokawa T, Tanaka H, Lee S, Yashiro M, Ohira M

    Gan to kagaku ryoho. Cancer & chemotherapy   48 ( 13 )   2073 - 2075   2021.12( ISSN:0385-0684

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  • Prognostic value of the density of tumor-infiltrating lymphocytes in colorectal cancer liver metastases.

    Wang E, Shibutani M, Nagahara H, Fukuoka T, Iseki Y, Okazaki Y, Kashiwagi S, Tanaka H, Maeda K

    Oncology letters   22 ( 6 )   837   2021.12( ISSN:1792-1074

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  • The Efficacy and Safety of Trifluridine/Tipiracil Treatment for Elderly Patients With Metastatic Colorectal Cancer in a Real-world Setting.

    Shibutani M, En W, Okazaki Y, Kashiwagi S, Fukuoka T, Iseki Y, Hirakawa K, Ohira M

    Anticancer research   41 ( 12 )   6211 - 6216   2021.12( ISSN:0250-7005

  • [A Fatal Case of Meningeal Carcinomatosis in a Rectal Cancer Patient Diagnosed with Pathologic Complete Response after Neoadjuvant Chemoradiotherapy].

    Yokomatsu H, Katsuragi K, Xiang Z, Shibutani M

    Gan to kagaku ryoho. Cancer & chemotherapy   48 ( 13 )   1673 - 1675   2021.12( ISSN:0385-0684

  • [A Case of Hyperammonemic Encephalopathy following mFOLFOX6 plus Panitumumab Therapy for Rectal Cancer].

    Tsujio G, Muguruma K, Eguchi S, Iseki Y, Miki Y, Yoshii M, Fukuoka T, Tamura T, Shibutani M, Nagahara H, Toyokawa T, Tanaka H, Lee S, Yashiro M, Ohira M

    Gan to kagaku ryoho. Cancer & chemotherapy   48 ( 13 )   2073 - 2075   2021.12( ISSN:0385-0684

  • Prediction of survival after eribulin chemotherapy for breast cancer by absolute lymphocyte counts and progression types.

    Morisaki T, Kashiwagi S, Asano Y, Goto W, Takada K, Ishihara S, Shibutani M, Tanaka H, Hirakawa K, Ohira M

    World journal of surgical oncology   19 ( 1 )   324   2021.11

  • Impact of Intraoperative Blood Loss and Blood Transfusion on the Prognosis of Colorectal Liver Metastasis Following Curative Resection.

    Masatsune S, Kimura K, Kashiwagi S, En W, Okazaki Y, Maeda K, Hirakawa K, Ohira M

    Anticancer research   41 ( 11 )   5617 - 5623   2021.11( ISSN:0250-7005

  • Clinical verification of body mass index and tumor immune response in patients with breast cancer receiving preoperative chemotherapy.

    Takada K, Kashiwagi S, Asano Y, Goto W, Ishihara S, Morisaki T, Shibutani M, Tanaka H, Hirakawa K, Ohira M

    BMC cancer   21 ( 1 )   1129   2021.10

  • Efficacy of adjuvant chemotherapy after complete resection of pulmonary metastasis from colorectal cancer.

    Okazaki Y, Shibutani M, Wang E, Nagahara H, Fukuoka T, Iseki Y, Maeda K, Hirakawa K, Ohira M

    Molecular and clinical oncology   15 ( 4 )   205   2021.10( ISSN:2049-9450

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  • The Impact of Intraoperative Blood Loss on the Survival After Laparoscopic Surgery for Colorectal Cancer.

    Shibutani M, Maeda K, Kashiwagi S, Hirakawa K, Ohira M

    Anticancer research   41 ( 9 )   4529 - 4534   2021.09( ISSN:0250-7005

  • The Impact of Tumor-associated Macrophages on Chemoresistance <i>via</i> Angiogenesis in Colorectal Cancer.

    Shibutani M, Nakao S, Maeda K, Nagahara H, Kashiwagi S, Hirakawa K, Ohira M

    Anticancer research   41 ( 9 )   4447 - 4453   2021.09( ISSN:0250-7005

  • Effect of Adjuvant Chemotherapy on Survival of Elderly Patients With Stage III Colorectal Cancer.

    Shibutani M, Maeda K, Kashiwagi S, Hirakawa K, Ohira M

    Anticancer research   41 ( 7 )   3615 - 3624   2021.07( ISSN:0250-7005

  • Lactate Dehydrogenase Is a Useful Marker for Predicting the Efficacy of Bevacizumab-containing Chemotherapy in Patients With Metastatic Colorectal Cancer.

    Shibutani M, Maeda K, Kashiwagi S, Nagahara H, Fukuoka T, Iseki Y, Wang EN, Okazaki Y, Hirakawa K, Ohira M

    Anticancer research   41 ( 7 )   3535 - 3542   2021.07( ISSN:0250-7005

  • Prediction of distant metastatic recurrence by tumor-infiltrating lymphocytes in hormone receptor-positive breast cancer.

    Takada K, Kashiwagi S, Asano Y, Goto W, Kouhashi R, Yabumoto A, Ishihara S, Morisaki T, Shibutani M, Tanaka H, Hirakawa K, Ohira M

    BMC women's health   21 ( 1 )   225   2021.05

  • Elevated Postoperative Levels of Serum C-reactive Protein Are Associated With Shorter Long-term Survival After Resection of Colorectal Liver Metastases, Regardless of the Occurrence of Infectious Complications.

    Shibutani M, Kimura K, Kashiwagi S, Wang EN, Okazaki Y, Maeda K, Hirakawa K, Ohira M

    Anticancer research   41 ( 5 )   2605 - 2610   2021.05( ISSN:0250-7005

  • 特集 消化器・一般外科におけるCommon Diseaseの手術 エルステから高難度まで I 虫垂炎手術 10 虫垂炎に対する開腹手術・開腹移行

    福岡 達成, 永原 央, 渋谷 雅常, 井関 康仁, 小川 正文, 大平 雅一

    手術   75 ( 4 )   445 - 452   2021.04( ISSN:00374423

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  • Prognostic Significance of the Immunological Indices in Patients Who Underwent Complete Resection of Pulmonary Metastases of Colorectal Cancer.

    Okazaki Y, Shibutani M, Wang EN, Nagahara H, Fukuoka T, Iseki Y, Kashiwagi S, Tanaka H, Maeda K, Hirakawa K, Ohira M

    In vivo (Athens, Greece)   35 ( 2 )   1091 - 1100   2021.03( ISSN:0258-851X

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  • A High Postoperative Serum C-reactive Protein Level Has a Negative Impact on Long-term Survival, Regardless of Postoperative Infectious Complications, in Patients Who Undergo Laparoscopic Surgery for Colorectal Cancer.

    Shibutani M, En W, Okazaki Y, Maeda K, Hirakawa K, Ohira M

    Anticancer research   41 ( 3 )   1593 - 1598   2021.03( ISSN:0250-7005

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    Authorship:Lead author  

    DOI: 10.21873/anticanres.14920

    PubMed

  • A Case of the Large Rectal GIST Treated by Laparoscopic Anus Preserving Operation after Neoadjuvant Therapy with Imatinib Mesylate

    Matsuzuka S.

    Japanese Journal of Cancer and Chemotherapy   48 ( 3 )   385 - 387   2021.03( ISSN:03850684

  • [A Case of the Large Rectal GIST Treated by Laparoscopic Anus Preserving Operation after Neoadjuvant Therapy with Imatinib Mesylate].

    Matsuzuka S, Iseki Y, Fukuoka T, Shibutani M, Nagahara H, Miki Y, Yoshii M, Tamura T, Toyokawa T, Tanaka H, Lee S, Muguruma K, Ohira M

    Gan to kagaku ryoho. Cancer & chemotherapy   48 ( 3 )   385 - 387   2021.03( ISSN:0385-0684

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  • A Case of the Large Rectal GIST Treated by Laparoscopic Anus Preserving Operation after Neoadjuvant Therapy with Imatinib Mesylate

    Matsuzuka S

    Japanese Journal of Cancer and Chemotherapy   48 ( 3 )   385 - 387   2021.03( ISSN:0385-0684

  • [A Case of the Large Rectal GIST Treated by Laparoscopic Anus Preserving Operation after Neoadjuvant Therapy with Imatinib Mesylate].

    Matsuzuka S, Iseki Y, Fukuoka T, Shibutani M, Nagahara H, Miki Y, Yoshii M, Tamura T, Toyokawa T, Tanaka H, Lee S, Muguruma K, Ohira M

    Gan to kagaku ryoho. Cancer & chemotherapy   48 ( 3 )   385 - 387   2021.03( ISSN:0385-0684

  • Lymphopenia associated with adjuvant chemotherapy after potentially curative surgery for colorectal cancer correlates with recurrence

    Shibutani M.

    International Surgery   105 ( 1 )   146 - 151   2021( ISSN:00208868

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  • Abundant intratumoral fibrosis prevents lymphocyte infiltration into peritoneal metastases of colorectal cancer.

    Wang E, Shibutani M, Nagahara H, Fukuoka T, Iseki Y, Okazaki Y, Kashiwagi S, Tanaka H, Maeda K, Hirakawa K, Ohira M

    PloS one   16 ( 7 )   e0255049   2021

  • Spontaneous rupture of pancreatic Acinar cell carcinoma: Report of a case

    Yamazoe S.

    International Surgery   105 ( 1-3 )   353 - 358   2021( ISSN:00208868

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  • Inhibitory effects of iron depletion plus eribulin on the breast cancer microenvironment.

    Goto W, Kashiwagi S, Asano Y, Takada K, Morisaki T, Takahashi K, Fujita H, Shibutani M, Amano R, Takashima T, Tomita S, Hirakawa K, Ohira M

    BMC cancer   20 ( 1 )   1215   2020.12

  • A Case of Submucosal-Like Tumor at Cecum That Was Diagnosed as Colon Metastasis from Gastric Cancer

    Okazaki Y.

    Gan to kagaku ryoho. Cancer &amp; chemotherapy   47 ( 13 )   2343 - 2345   2020.12( ISSN:03850684

  • A Case of Submucosal-Like Tumor at Cecum That Was Diagnosed as Colon Metastasis from Gastric Cancer

    Okazaki Y

    Gan to kagaku ryoho. Cancer &amp; chemotherapy   47 ( 13 )   2343 - 2345   2020.12( ISSN:0385-0684

  • A case of advanced rectal cancer with metastasis successfully treated with an anti-vascular endothelial growth factor (VEGF) drug

    Nagao M.

    Japanese Journal of Cancer and Chemotherapy   47 ( 12 )   1719 - 1721   2020.12( ISSN:03850684

  • [A Case of Submucosal-Like Tumor at Cecum That Was Diagnosed as Colon Metastasis from Gastric Cancer].

    Okazaki Y, Shibutani M, Nagahara H, Fukuoka T, Iseki Y, Wang E, Maeda K, Hirakawa K, Ohira M

    Gan to kagaku ryoho. Cancer & chemotherapy   47 ( 13 )   2343 - 2345   2020.12( ISSN:0385-0684

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  • [A Case of Advanced Rectal Cancer with Metastasis Successfully Treated with an Anti-Vascular Endothelial Growth Factor (VEGF) Drug].

    Nagao M, Iseki Y, Nagahara H, Shibutani M, Fukuoka T, Sasaki M, Yoshii M, Tamura T, Toyokawa T, Tanaka H, Ri S, Muguruma K, Ohira M

    Gan to kagaku ryoho. Cancer & chemotherapy   47 ( 12 )   1719 - 1721   2020.12( ISSN:0385-0684

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  • A case of advanced rectal cancer with metastasis successfully treated with an anti-vascular endothelial growth factor (VEGF) drug

    Nagao M

    Japanese Journal of Cancer and Chemotherapy   47 ( 12 )   1719 - 1721   2020.12( ISSN:0385-0684

  • [A Case of Submucosal-Like Tumor at Cecum That Was Diagnosed as Colon Metastasis from Gastric Cancer].

    Okazaki Y, Shibutani M, Nagahara H, Fukuoka T, Iseki Y, Wang E, Maeda K, Hirakawa K, Ohira M

    Gan to kagaku ryoho. Cancer & chemotherapy   47 ( 13 )   2343 - 2345   2020.12( ISSN:0385-0684

  • [A Case of Advanced Rectal Cancer with Metastasis Successfully Treated with an Anti-Vascular Endothelial Growth Factor (VEGF) Drug].

    Nagao M, Iseki Y, Nagahara H, Shibutani M, Fukuoka T, Sasaki M, Yoshii M, Tamura T, Toyokawa T, Tanaka H, Ri S, Muguruma K, Ohira M

    Gan to kagaku ryoho. Cancer & chemotherapy   47 ( 12 )   1719 - 1721   2020.12( ISSN:0385-0684

  • Significance of age-associated quality of life in patients with stage IV breast cancer who underwent endocrine therapy in Japan.

    Takada K, Kashiwagi S, Asano Y, Goto W, Morisaki T, Takahashi K, Shibutani M, Amano R, Takashima T, Tomita S, Hirakawa K, Ohira M

    Oncology letters   20 ( 5 )   180   2020.11( ISSN:1792-1074

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  • Predicting therapeutic efficacy of endocrine therapy for stage IV breast cancer by tumor-infiltrating lymphocytes.

    Asano Y, Kashiwagi S, Goto W, Takada K, Takahashi K, Shibutani M, Amano R, Takashima T, Tomita S, Hirakawa K, Ohira M

    Molecular and clinical oncology   13 ( 2 )   195 - 202   2020.08( ISSN:2049-9450

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  • Combining Bevacizumab With Trifluridine/Thymidine Phosphorylase Inhibitor Improves the Survival Outcomes Regardless of the Usage History of Bevacizumab in Front-line Treatment of Patients With Metastatic Colorectal Cancer. Reviewed

    Shibutani M, Nagahara H, Fukuoka T, Iseki Y, Wang EN, Okazaki Y, Kashiwagi S, Maeda K, Hirakawa K, Ohira M

    Anticancer research   40 ( 7 )   4157 - 4163   2020.07( ISSN:0250-7005

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.21873/anticanres.14415

    PubMed

  • Combining Bevacizumab With Trifluridine/Thymidine Phosphorylase Inhibitor Improves the Survival Outcomes Regardless of the Usage History of Bevacizumab in Front-line Treatment of Patients With Metastatic Colorectal Cancer. Reviewed

    Shibutani M, Nagahara H, Fukuoka T, Iseki Y, Wang EN, Okazaki Y, Kashiwagi S, Maeda K, Hirakawa K, Ohira M

    Anticancer research   40 ( 7 )   4157 - 4163   2020.07( ISSN:0250-7005

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.21873/anticanres.14415

    PubMed

  • Prediction of lymph node metastasis by tumor-infiltrating lymphocytes in T1 breast cancer Reviewed

    Takada Koji, Kashiwagi Shinichiro, Asano Yuka, Goto Wataru, Kouhashi Rika, Yabumoto Akimichi, Morisaki Tamami, Shibutani Masatsune, Takashima Tsutomu, Fujita Hisakazu, Hirakawa Kosei, Ohira Masaichi

    BMC CANCER   20 ( 1 )   598   2020.06

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s12885-020-07101-y

    PubMed

  • Prediction of lymph node metastasis by tumor-infiltrating lymphocytes in T1 breast cancer Reviewed

    Takada Koji, Kashiwagi Shinichiro, Asano Yuka, Goto Wataru, Kouhashi Rika, Yabumoto Akimichi, Morisaki Tamami, Shibutani Masatsune, Takashima Tsutomu, Fujita Hisakazu, Hirakawa Kosei, Ohira Masaichi

    BMC CANCER   20 ( 1 )   598 - 598   2020.06

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    Publishing type:Research paper (scientific journal)   International / domestic magazine:International journal  

    BACKGROUND: Lymph node metastasis is more likely in early-stage breast cancer with lower tumor-infiltrating lymphocyte (TIL) density. Therefore, we investigated the correlation between TILs and lymph node metastasis in cT1 breast cancer patients undergoing surgery and the usefulness of TILs in predicting sentinel lymph node metastasis (SLNM) in cT1N0M0 breast cancer. METHODS: We investigated 332 breast cancer patients who underwent surgery as the first-line treatment after preoperative diagnosis of cT1. A positive diagnosis of SLNM as an indication for axillary clearance was defined as macrometastasis in the sentinel lymph node (SLN) (macrometastasis: tumor diameter > 2 mm). Semi-quantitative evaluation of lymphocytes infiltrating the peritumoral stroma as TILs in primary tumor biopsy specimens prior to treatment was conducted. RESULTS: For SLN biopsy (SLNB), a median of 2 (range, 1-8) SLNs were pathologically evaluated. Sixty cases (19.4%) of SLNM (macrometastasis: 46, micrometastasis: 16) were observed. Metastasis was significantly greater in breast cancers with tumor diameter > 10 mm than in those with diameter ≤ 10 mm (p = 0.016). Metastasis was significantly associated with lymphatic invasion (p < 0.001). These two clinicopathological factors correlated with SLNM even in patients diagnosed with cN0 (tumor size; p = 0.017, lymphatic invasion; p = 0.002). Multivariate analysis for SLNM predictors revealed lymphatic invasion (p = 0.008, odds ratio [OR] = 2.522) and TILs (p < 0.001, OR = 0.137) as independent factors. CONCLUSIONS: Our results suggest a correlation between lymph node metastasis and tumor immune-microenvironment in cT1 breast cancer. TIL density may be a predictor of SLNM in breast cancer without lymph node metastasis on preoperative imaging.

    DOI: 10.1186/s12885-020-07101-y

    PubMed

  • Liver abscess caused by fish bone perforation of Meckel's diverticulum: a case report Reviewed

    Natsuki Seiji, Iseki Yasuhito, Nagahara Hishashi, Fukuoka Tatsunari, Shibutani Masatsune, Ohira Masaichi

    BMC SURGERY   20 ( 1 )   121   2020.06

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s12893-020-00783-y

    PubMed

  • Liver abscess caused by fish bone perforation of Meckel's diverticulum: a case report Reviewed

    Natsuki Seiji, Iseki Yasuhito, Nagahara Hishashi, Fukuoka Tatsunari, Shibutani Masatsune, Ohira Masaichi

    BMC SURGERY   20 ( 1 )   121   2020.06

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s12893-020-00783-y

    PubMed

  • Inflammation caused by surgical stress has a negative impact on the long-term survival outcomes in patients with colorectal cancer

    Shibutani M.

    Anticancer Research   40 ( 6 )   3535 - 3542   2020.06( ISSN:02507005

  • Inflammation Caused by Surgical Stress Has a Negative Impact on the Long-term Survival Outcomes in Patients With Colorectal Cancer Reviewed

    Shibutani Masatsune, Nakao Shigetomi, Maeda Kiyoshi, Nagahara His Ashi, Fukuoka Tatsunari, Iseki Yasuhito, Hirakawa Kosei, Ohira Masaichi

    ANTICANCER RESEARCH   40 ( 6 )   3535 - 3542   2020.06( ISSN:0250-7005

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.21873/anticanres.14342

    PubMed

  • Inflammation Caused by Surgical Stress Has a Negative Impact on the Long-term Survival Outcomes in Patients With Colorectal Cancer Reviewed

    Shibutani Masatsune, Nakao Shigetomi, Maeda Kiyoshi, Nagahara His Ashi, Fukuoka Tatsunari, Iseki Yasuhito, Hirakawa Kosei, Ohira Masaichi

    ANTICANCER RESEARCH   40 ( 6 )   3535 - 3542   2020.06( ISSN:0250-7005

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.21873/anticanres.14342

    PubMed

  • Preoperative Neutrophil-to-lymphocyte Ratio Predicts Tumor-infiltrating CD8(+) T Cells in Biliary Tract Cancer Reviewed

    Tanaka Ryota, Kimura Kenjiro, Eguchi Shinpei, Tauchi Jun, Shibutani Masatune, Shinkawa Hiroji, Ohira Go, Yamazoe Sadaaki, Tanaka Shogo, Amano Ryosuke, Tanaka Hiroaki, Yashiro Masakazu, Kubo Shoji, Ohira Masaichi

    ANTICANCER RESEARCH   40 ( 5 )   2881 - 2887   2020.05( ISSN:0250-7005

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.21873/anticanres.14264

  • Preoperative Neutrophil-to-lymphocyte Ratio Predicts Tumor-infiltrating CD8(+) T Cells in Biliary Tract Cancer Reviewed

    Tanaka Ryota, Kimura Kenjiro, Eguchi Shinpei, Tauchi Jun, Shibutani Masatune, Shinkawa Hiroji, Ohira Go, Yamazoe Sadaaki, Tanaka Shogo, Amano Ryosuke, Tanaka Hiroaki, Yashiro Masakazu, Kubo Shoji, Ohira Masaichi

    ANTICANCER RESEARCH   40 ( 5 )   2881 - 2887   2020.05( ISSN:0250-7005

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.21873/anticanres.14264

  • The effect of smoking on biological change of recurrent breast cancer Reviewed

    Takada Koji, Kashiwagi Shinichiro, Asano Yuka, Goto Wataru, Kouhashi Rika, Yabumoto Akimichi, Morisaki Tamami, Fujita Hisakazu, Shibutani Masatsune, Takashima Tsutomu, Hirakawa Kosei, Ohira Masaichi

    JOURNAL OF TRANSLATIONAL MEDICINE   18 ( 1 )   153   2020.04

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s12967-020-02307-x

    PubMed

  • The effect of smoking on biological change of recurrent breast cancer Reviewed

    Takada Koji, Kashiwagi Shinichiro, Asano Yuka, Goto Wataru, Kouhashi Rika, Yabumoto Akimichi, Morisaki Tamami, Fujita Hisakazu, Shibutani Masatsune, Takashima Tsutomu, Hirakawa Kosei, Ohira Masaichi

    JOURNAL OF TRANSLATIONAL MEDICINE   18 ( 1 )   153 - 153   2020.04

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    Publishing type:Research paper (scientific journal)   International / domestic magazine:International journal  

    BACKGROUND: The selection of treatment for a patient with breast cancer largely relies on the cancer subtype. However, this process is complicated by changes in tumor biology at relapse. Smoking has been identified as a risk factor for breast cancer. The direct effect of a tobacco component delivered via blood circulation on the mammary gland tissue and subsequent DNA damage have been proposed to explain the association between cigarette smoking and breast cancer carcinogenesis. This postulation is supported by both tissue culture and animal studies demonstrating that the associated DNA damage further alters breast cancer cells, as indicated by an increased proliferative capacity and malignant transformation. In this study, we aimed to explore the relationship between changes in Estrogen receptor (ER), progesterone receptor (PgR), and human epidermal growth factor receptor 2 (HER2) each receptor at recurrence, and smoking and the prognosis after recurrence. METHODS: This retrospective study included 989 patients with primary breast cancer who developed relapse after surgery and 50 patients who underwent regenerative biopsy or surgery from December 2007 to March 2018. ER, PgR, and HER2 expression in the primary and recurrent lesions was evaluated using immunohistochemistry, and the correlations of these expression patterns with smoking history (pack-years) were examined. RESULTS: When ER was evaluated in recurrent tumors, negative and positive conversions were recognized in 3 (6.0%) and 1 patient (2.0%), respectively. When PgR was evaluated, negative conversion was recognized in 15 patients (30.0%). When HER2 was evaluated, positive conversion was recognized in 6 patients (12.0%). Consequently, we observed a change in the intrinsic subtype in in 5 patients with recurrent tumors (10.0%). Although most clinical factors were not correlated with smoking, a positive conversion of HER2 in recurrence was significantly more frequent among smokers than among non-smokers (p = 0.024). CONCLUSIONS: Biological changes during breast cancer recurrence should be given careful clinical consideration because they affect treatment after recurrence. Our results suggest that smoking may induce increased HER2 expression in recurrent breast tumors.

    DOI: 10.1186/s12967-020-02307-x

    PubMed

  • Prediction of Sentinel Lymph Node Metastasis Using the Platelet-to-lymphocyte Ratio in T1 Breast Cancer Reviewed

    Takada Koji, Kashiwagi Shinichiro, Asano Yuka, Goto Wataru, Kouhashi Rika, Yabumoto Akimichi, Morisaki Tamami, Shibutani Masatsune, Takashima Tsutomu, Fujita Hisakazu, Hirakawa Kosei, Ohira Masaichi

    ANTICANCER RESEARCH   40 ( 4 )   2343 - 2349   2020.04( ISSN:0250-7005

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.21873/anticanres.14202

    PubMed

  • Prediction of Sentinel Lymph Node Metastasis Using the Platelet-to-lymphocyte Ratio in T1 Breast Cancer Reviewed

    Takada Koji, Kashiwagi Shinichiro, Asano Yuka, Goto Wataru, Kouhashi Rika, Yabumoto Akimichi, Morisaki Tamami, Shibutani Masatsune, Takashima Tsutomu, Fujita Hisakazu, Hirakawa Kosei, Ohira Masaichi

    ANTICANCER RESEARCH   40 ( 4 )   2343 - 2349   2020.04( ISSN:0250-7005

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    Publishing type:Research paper (scientific journal)   International / domestic magazine:International journal  

    BACKGROUND/AIM: The host's systemic inflammatory response is thought to affect the progression of cancer and the antitumor effects of chemotherapy. Meta-analyses have reported that the peripheral blood platelet-to-lymphocyte ratio (PLR) is a prognostic indicator of this effect. Therefore, we hypothesized that PLR may differ, depending on sentinel lymph node metastasis (SLNM) in patients diagnosed with cT1N0M0 breast cancer by preoperative imaging. This study investigated the ability of preoperative PLR to predict SLNM in patients diagnosed with cT1N0M0 breast cancer. PATIENTS AND METHODS: This study included 475 patients with cT1N0M0 breast cancer diagnosed by preoperative imaging. Peripheral blood was obtained at diagnosis, i.e., before surgery. PLR was calculated from preoperative blood tests, by dividing the absolute platelet count by the absolute lymphocyte count. RESULTS: The probability of SLNM was significantly higher (p=0.002) in cases where the tumor diameter was larger than 10 mm. The incidence of SLNM was significantly high in the high (preoperative) PLR group (p=0.031). Multivariate analysis revealed that high PLR [compared to low PLR, p=0.021, odds ratio (OR)=1.815, 95% confidence interval (CI)=1.093-3.090] and large tumor size (compared to small tumor size, p=0.001, OR=2.688, 95%CI=1.524-4.997) were independent factors influencing SLNM. CONCLUSION: PLR may act as a predictor of SLNM in cT1N0M0 breast cancer.

    DOI: 10.21873/anticanres.14202

    PubMed

  • Case Report : Five cases of ileal neuroendocrine tumor

    82 ( 1 )   73 - 77   2020.01( ISSN:0016593X

  • Prognostic Significance of Neoadjuvant Rectal Score and Indication for Postoperative Adjuvant Therapy in Rectal Cancer Patients After Neoadjuvant Chemoradiotherapy Reviewed

    Maeda Kiyoshi, Shibutani Masatsune, Tachimori Akiko, Nishii Takafumi, Aomatsu Naoki, Fukuoka Tatsunari, Nagahara Hisashi, Otani Hiroshi, Inoue Toru, Ohira Masaichi

    IN VIVO   34 ( 1 )   283 - 289   2020.01( ISSN:0258-851X

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.21873/invivo.11772

    PubMed

  • Prognostic Significance of Neoadjuvant Rectal Score and Indication for Postoperative Adjuvant Therapy in Rectal Cancer Patients After Neoadjuvant Chemoradiotherapy Reviewed

    Maeda Kiyoshi, Shibutani Masatsune, Tachimori Akiko, Nishii Takafumi, Aomatsu Naoki, Fukuoka Tatsunari, Nagahara Hisashi, Otani Hiroshi, Inoue Toru, Ohira Masaichi

    IN VIVO   34 ( 1 )   283 - 289   2020( ISSN:0258-851X

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.21873/invivo.11772

    PubMed

  • Novel prognostic biomarkers of pouchitis after ileal pouch-anal anastomosis for ulcerative colitis: Neutrophil-to-lymphocyte ratio.

    Nishida Y, Hosomi S, Yamagami H, Fujimoto K, Nakata R, Itani S, Nadatani Y, Fukunaga S, Otani K, Tanaka F, Nagami Y, Taira K, Kamata N, Watanabe T, Iseki Y, Fukuoka T, Shibutani M, Nagahara H, Ohfuji S, Fujiwara Y

    PloS one   15 ( 10 )   e0241322   2020

  • A Case of a Patient with Type Ⅳ Adachi Classification Treated with Laparoscopic Ileocecal Resection

    Sasaki M.

    Gan to kagaku ryoho. Cancer &amp; chemotherapy   46 ( 13 )   2416 - 2418   2019.12( ISSN:03850684

  • A Case of Laparoscopic Abdominoperineal Resection for Rectal Cancer with Left-Sided Inferior Vena Cava

    Maruo K.

    Gan to kagaku ryoho. Cancer &amp; chemotherapy   46 ( 13 )   2443 - 2445   2019.12( ISSN:03850684

  • [A Case of a Patient with Type Ⅳ Adachi Classification Treated with Laparoscopic Ileocecal Resection]. Reviewed

    Sasaki M, Iseki Y, Fukuoka T, Shibutani M, Nagahara H, Ohira M

    Gan to kagaku ryoho. Cancer & chemotherapy   46 ( 13 )   2416 - 2418   2019.12( ISSN:0385-0684

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    Publishing type:Research paper (scientific journal)  

    PubMed

  • [A Case of a Patient with Type Ⅳ Adachi Classification Treated with Laparoscopic Ileocecal Resection]. Reviewed

    Sasaki M, Iseki Y, Fukuoka T, Shibutani M, Nagahara H, Ohira M

    Gan to kagaku ryoho. Cancer & chemotherapy   46 ( 13 )   2416 - 2418   2019.12( ISSN:0385-0684

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    Publishing type:Research paper (scientific journal)  

    PubMed

  • Adachi分類IV型の腹腔動脈、上腸間膜動脈分枝形態を有する症例に対して腹腔鏡下回盲部切除術を施行した1例 Reviewed

    佐々木 麻帆, 井関 康仁, 福岡 達成, 澁谷 雅常, 永原 央, 大平 雅一

    (株)癌と化学療法社 癌と化学療法   46 ( 13 )   2416 - 2418   2019.12( ISSN:0385-0684

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    Publishing type:Research paper (scientific journal)  

    腹腔動脈には様々な分枝形態があり、その分類の一つとしてAdachi分類が知られている。Adachi分類は腹部大動脈からの分枝である腹腔動脈およびその分枝である左胃動脈、総肝動脈、脾動脈、また上腸間膜動脈の分枝形態をI〜VI型、さらに肝動脈の変異を組み合わせて28群に区分し報告されている。このI〜VIの型のうち本症例はIV型に相当し、その頻度は2.4%と極めてまれな分枝形態である。今回われわれは、Adachi分類IV型の分枝形態をもつ患者に対して術前にその分枝形態を診断し、腹腔鏡下回盲部切除術を安全に施行し得た1例を経験したので報告する。(著者抄録)

  • [A Case of Laparoscopic Abdominoperineal Resection for Rectal Cancer with Left-Sided Inferior Vena Cava]. Reviewed

    Maruo K, Iseki Y, Fukuoka T, Shibutani M, Nagahara H, Tamura T, Toyokawa T, Tanaka H, Lee S, Muguruma K, Ohira M

    Gan to kagaku ryoho. Cancer & chemotherapy   46 ( 13 )   2443 - 2445   2019.12( ISSN:0385-0684

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    Publishing type:Research paper (scientific journal)  

    PubMed

  • Adachi分類IV型の腹腔動脈、上腸間膜動脈分枝形態を有する症例に対して腹腔鏡下回盲部切除術を施行した1例 Reviewed

    佐々木 麻帆, 井関 康仁, 福岡 達成, 澁谷 雅常, 永原 央, 大平 雅一

    (株)癌と化学療法社 癌と化学療法   46 ( 13 )   2416 - 2418   2019.12( ISSN:0385-0684

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    Publishing type:Research paper (scientific journal)  

    腹腔動脈には様々な分枝形態があり、その分類の一つとしてAdachi分類が知られている。Adachi分類は腹部大動脈からの分枝である腹腔動脈およびその分枝である左胃動脈、総肝動脈、脾動脈、また上腸間膜動脈の分枝形態をI〜VI型、さらに肝動脈の変異を組み合わせて28群に区分し報告されている。このI〜VIの型のうち本症例はIV型に相当し、その頻度は2.4%と極めてまれな分枝形態である。今回われわれは、Adachi分類IV型の分枝形態をもつ患者に対して術前にその分枝形態を診断し、腹腔鏡下回盲部切除術を安全に施行し得た1例を経験したので報告する。(著者抄録)

  • Adachi分類IV型の腹腔動脈、上腸間膜動脈分枝形態を有する症例に対して腹腔鏡下回盲部切除術を施行した1例

    佐々木 麻帆, 井関 康仁, 福岡 達成, 澁谷 雅常, 永原 央, 大平 雅一

    癌と化学療法   46 ( 13 )   2416 - 2418   2019.12( ISSN:0385-0684

     More details

    腹腔動脈には様々な分枝形態があり、その分類の一つとしてAdachi分類が知られている。Adachi分類は腹部大動脈からの分枝である腹腔動脈およびその分枝である左胃動脈、総肝動脈、脾動脈、また上腸間膜動脈の分枝形態をI〜VI型、さらに肝動脈の変異を組み合わせて28群に区分し報告されている。このI〜VIの型のうち本症例はIV型に相当し、その頻度は2.4%と極めてまれな分枝形態である。今回われわれは、Adachi分類IV型の分枝形態をもつ患者に対して術前にその分枝形態を診断し、腹腔鏡下回盲部切除術を安全に施行し得た1例を経験したので報告する。(著者抄録)

  • [A Case of Laparoscopic Abdominoperineal Resection for Rectal Cancer with Left-Sided Inferior Vena Cava]. Reviewed

    Maruo K, Iseki Y, Fukuoka T, Shibutani M, Nagahara H, Tamura T, Toyokawa T, Tanaka H, Lee S, Muguruma K, Ohira M

    Gan to kagaku ryoho. Cancer & chemotherapy   46 ( 13 )   2443 - 2445   2019.12( ISSN:0385-0684

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    Publishing type:Research paper (scientific journal)  

  • [A Case of Laparoscopic Abdominoperineal Resection for Rectal Cancer with Left-Sided Inferior Vena Cava].

    Maruo K, Iseki Y, Fukuoka T, Shibutani M, Nagahara H, Tamura T, Toyokawa T, Tanaka H, Lee S, Muguruma K, Ohira M

    Gan to kagaku ryoho. Cancer & chemotherapy   46 ( 13 )   2443 - 2445   2019.12( ISSN:0385-0684

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  • [A Case of a Patient with Type Ⅳ Adachi Classification Treated with Laparoscopic Ileocecal Resection]. Reviewed

    Sasaki M, Iseki Y, Fukuoka T, Shibutani M, Nagahara H, Ohira M

    Gan to kagaku ryoho. Cancer & chemotherapy   46 ( 13 )   2416 - 2418   2019.12( ISSN:0385-0684

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    Publishing type:Research paper (scientific journal)  

  • [A Case of a Patient with Type Ⅳ Adachi Classification Treated with Laparoscopic Ileocecal Resection]. Reviewed

    Sasaki M, Iseki Y, Fukuoka T, Shibutani M, Nagahara H, Ohira M

    Gan to kagaku ryoho. Cancer & chemotherapy   46 ( 13 )   2416 - 2418   2019.12( ISSN:0385-0684

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    Publishing type:Research paper (scientific journal)  

  • The efficacy of adjuvant chemotherapy according to the risk classification of recurrence based on the systemic inflammatory markers in patients with colorectal cancer liver metastases Reviewed

    Shibutani M., Nagahara H., Fukuoka T., Iseki Y., Hirakawa K., Ohira M.

    ANNALS OF ONCOLOGY   30   2019.11( ISSN:0923-7534

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  • Preoperative neutrophil-to-lymphocyte ratio is correlated with severe postoperative complications after emergency surgery for ulcerative colitis

    Maeda K.

    International Surgery   104 ( 11-12 )   514 - 521   2019.11( ISSN:00208868

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  • The efficacy of adjuvant chemotherapy according to the risk classification of recurrence based on the systemic inflammatory markers in patients with colorectal cancer liver metastases Reviewed

    Shibutani M, Nagahara H, Fukuoka T, Iseki Y, Hirakawa K, Ohira M

    ANNALS OF ONCOLOGY   30   2019.11( ISSN:0923-7534

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  • Clinical Evaluation of Dynamic Monitoring of Neutrophil-to-lymphocyte and Platelet-to-lymphocyte Ratios in Primary Endocrine Therapy for Advanced Breast Cancer Reviewed

    Takada Koji, Kashiwagi Shinichiro, Asano Yuka, Goto Wataru, Takahashi Katsuyuki, Shibutani Masatsune, Amano Ryosuke, Takashima Tsutomu, Tomita Shuhei, Hirakawa Kosei, Ohira Masaichi

    ANTICANCER RESEARCH   39 ( 10 )   5581 - 5588   2019.10( ISSN:0250-7005

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.21873/anticanres.13752

    PubMed

  • Clinical Evaluation of Dynamic Monitoring of Neutrophil-to-lymphocyte and Platelet-to-lymphocyte Ratios in Primary Endocrine Therapy for Advanced Breast Cancer.

    Takada K, Kashiwagi S, Asano Y, Goto W, Takahashi K, Shibutani M, Amano R, Takashima T, Tomita S, Hirakawa K, Ohira M

    Anticancer research   39 ( 10 )   5581 - 5588   2019.10( ISSN:0250-7005

  • A Case of Intestinal Tuberculosis which Developed a Jejunal Stenosis

    Sugimoto Atsushi, Fukuoka Tatsunari, Nagahara Hisashi, Shibutani Masatsune, Iseki Yasuhito, Matsutani Shinji, Wang En, Ohira Masaichi

    Nihon Fukubu Kyukyu Igakkai Zasshi (Journal of Abdominal Emergency Medicine)   39 ( 6 )   1087 - 1090   2019.09( ISSN:13402242

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    <p>A 45-year-old woman from Peru presented with vomiting and abdominal pain. Colonoscopy revealed erosions and ulceration in the cecum. Double balloon endoscopy revealed jejunal stenosis. Although the patient had no evidence of pulmonary tuberculosis, a T-spot TB test was positive. She developed an intestinal obstruction and required emergency surgery. There was a lower jejunal obstruction 220 cm from the ligament of Treitz. A single-port laparoscopic partial jejunectomy was performed. On day 14 after surgery, Mycobacterium tuberculosis was detected in a mucosal culture, indicating a diagnosis of intestinal tuberculosis. Intestinal tuberculosis frequently develops in the ileocecal area but rarely in the jejunum. As the foreign-born population in Japan increases, people with tuberculosis will increasingly be seen. Intestinal tuberculosis should be considered in the differential diagnosis of non-neoplastic intestinal obstruction in individuals from countries with a high incidence of tuberculosis.</p>

    DOI: 10.11231/jaem.39.1087

    CiNii Article

  • Change in PMI During Neoadjuvant Therapy Is a Predictive Prognostic Marker in Rectal Cancer Reviewed

    Fukuoka Tatsunari, Maeda Kiyoshi, Nagahara Hisashi, Shibutani Masatsune, Iseki Yasuhito, Matsutani Shinji, Hirakawa Kosei, Ohira Masaichi

    ANTICANCER RESEARCH   39 ( 9 )   5157 - 5163   2019.09( ISSN:0250-7005

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.21873/anticanres.13711

    PubMed

  • Efficacy of Adjuvant Chemotherapy According to the Classification of Recurrence Risk Based on Systemic Inflammatory Markers in Patients With Liver Metastases of Colorectal Cancer Reviewed

    Shibutani Masatsune, Nagahara Hisashi, Fukuoka Tatsunari, Iseki Yasuhito, Hirakawa Kosei, Ohira Masaichi

    ANTICANCER RESEARCH   39 ( 9 )   5039 - 5045   2019.09( ISSN:0250-7005

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.21873/anticanres.13695

    PubMed

  • Efficacy of Adjuvant Chemotherapy According to the Classification of Recurrence Risk Based on Systemic Inflammatory Markers in Patients With Liver Metastases of Colorectal Cancer Reviewed

    Shibutani Masatsune, Nagahara Hisashi, Fukuoka Tatsunari, Iseki Yasuhito, Hirakawa Kosei, Ohira Masaichi

    ANTICANCER RESEARCH   39 ( 9 )   5039 - 5045   2019.09( ISSN:0250-7005

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.21873/anticanres.13695

    PubMed

  • Change in PMI During Neoadjuvant Therapy Is a Predictive Prognostic Marker in Rectal Cancer Reviewed

    Fukuoka Tatsunari, Maeda Kiyoshi, Nagahara Hisashi, Shibutani Masatsune, Iseki Yasuhito, Matsutani Shinji, Hirakawa Kosei, Ohira Masaichi

    ANTICANCER RESEARCH   39 ( 9 )   5157 - 5163   2019.09( ISSN:0250-7005

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.21873/anticanres.13711

    PubMed

  • Two cases of small intestinal GIST which showed cavitation and mimicked malignant lymphoma of aneurysmal type Reviewed

    64 ( 9 )   1173 - 1179   2019.08( ISSN:00099252

  • The Effects of Eribulin on Breast Cancer Microenvironment Identified Using Eribulin-resistant Breast Cancer Cell Lines Reviewed

    Goto Wataru, Kashiwagi Shinichiro, Asano Yuka, Takada Koji, Takahashi Katsuyuki, Fujita Hisakazu, Takashima Tsutomu, Shibutani Masatsune, Amano Ryosuke, Tomita Shuhei, Hirakawa Kosei, Ohira Masaichi

    ANTICANCER RESEARCH   39 ( 8 )   4031 - 4041   2019.08( ISSN:0250-7005

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.21873/anticanres.13559

    PubMed

  • 動脈瘤型腸管悪性リンパ腫様のCT所見を呈した小腸GISTの2例 Reviewed

    藤井 啓輔, 植木 愛, 小山 孝一, 小林 彰太郎, 澁谷 雅常, 永原 央, 下野 太郎, 三木 幸雄

    金原出版(株) 臨床放射線   64 ( 9 )   1173 - 1179   2019.08( ISSN:0009-9252

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    症例1は50歳代男性で、1年前から繰り返す黒色便、貧血症状を主訴に前医を受診し、精査目的に当院を受診した。腹部dynamic造影CT所見では、空腸に長径7.5cmの腫瘤を認め、一見、全周性の不整な空腸壁肥厚をきたしているようにみえた。小腸部分切除術が施行され、ミクロ像では紡錘形細胞の増生とCD34陽性細胞を認めた。核分裂像数は高倍率50視野で36個認め、高リスク群のGISTと診断された。症例2は60歳代男性で、3ヵ月前から繰り返す発熱と倦怠感で前医を受診し、腹部CTにて左腹部に腫瘤性病変を認めたため精査目的に当院を受診した。腹部dynamic造影CT所見では、空腸に長径12cmの腫瘤を認め、一見、全周性の不整な空腸壁肥厚をきたしているようにみえた。小腸部分切除術が施行され、ミクロ像では紡錘形細胞の増生とc-kit蛋白陽性細胞を認めた。核分裂像数は高倍率50視野で187個認め、高リスク群のGISTと診断された。

  • The Effects of Eribulin on Breast Cancer Microenvironment Identified Using Eribulin-resistant Breast Cancer Cell Lines.

    Goto W, Kashiwagi S, Asano Y, Takada K, Takahashi K, Fujita H, Takashima T, Shibutani M, Amano R, Tomita S, Hirakawa K, Ohira M

    Anticancer research   39 ( 8 )   4031 - 4041   2019.08( ISSN:0250-7005

  • 動脈瘤型腸管悪性リンパ腫様のCT所見を呈した小腸GISTの2例

    藤井 啓輔, 植木 愛, 小山 孝一, 小林 彰太郎, 澁谷 雅常, 永原 央, 下野 太郎, 三木 幸雄

    臨床放射線   64 ( 9 )   1173 - 1179   2019.08( ISSN:0009-9252

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    症例1は50歳代男性で、1年前から繰り返す黒色便、貧血症状を主訴に前医を受診し、精査目的に当院を受診した。腹部dynamic造影CT所見では、空腸に長径7.5cmの腫瘤を認め、一見、全周性の不整な空腸壁肥厚をきたしているようにみえた。小腸部分切除術が施行され、ミクロ像では紡錘形細胞の増生とCD34陽性細胞を認めた。核分裂像数は高倍率50視野で36個認め、高リスク群のGISTと診断された。症例2は60歳代男性で、3ヵ月前から繰り返す発熱と倦怠感で前医を受診し、腹部CTにて左腹部に腫瘤性病変を認めたため精査目的に当院を受診した。腹部dynamic造影CT所見では、空腸に長径12cmの腫瘤を認め、一見、全周性の不整な空腸壁肥厚をきたしているようにみえた。小腸部分切除術が施行され、ミクロ像では紡錘形細胞の増生とc-kit蛋白陽性細胞を認めた。核分裂像数は高倍率50視野で187個認め、高リスク群のGISTと診断された。

  • 動脈瘤型腸管悪性リンパ腫様のCT所見を呈した小腸GISTの2例 Reviewed

    藤井 啓輔, 植木 愛, 小山 孝一, 小林 彰太郎, 澁谷 雅常, 永原 央, 下野 太郎, 三木 幸雄

    金原出版(株) 臨床放射線   64 ( 9 )   1173 - 1179   2019.08( ISSN:0009-9252

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    Publishing type:Research paper (scientific journal)  

    症例1は50歳代男性で、1年前から繰り返す黒色便、貧血症状を主訴に前医を受診し、精査目的に当院を受診した。腹部dynamic造影CT所見では、空腸に長径7.5cmの腫瘤を認め、一見、全周性の不整な空腸壁肥厚をきたしているようにみえた。小腸部分切除術が施行され、ミクロ像では紡錘形細胞の増生とCD34陽性細胞を認めた。核分裂像数は高倍率50視野で36個認め、高リスク群のGISTと診断された。症例2は60歳代男性で、3ヵ月前から繰り返す発熱と倦怠感で前医を受診し、腹部CTにて左腹部に腫瘤性病変を認めたため精査目的に当院を受診した。腹部dynamic造影CT所見では、空腸に長径12cmの腫瘤を認め、一見、全周性の不整な空腸壁肥厚をきたしているようにみえた。小腸部分切除術が施行され、ミクロ像では紡錘形細胞の増生とc-kit蛋白陽性細胞を認めた。核分裂像数は高倍率50視野で187個認め、高リスク群のGISTと診断された。

  • 症例報告 Persistent descending mesocolonに伴う内ヘルニアを合併した完全内臓逆位の1例

    辻尾 元, 福岡 達成, 永原 央, 渋谷 雅常, 井関 康人, 大平 雅一

    日本内視鏡外科学会雑誌   24 ( 4 )   340 - 344   2019.07( ISSN:13446703

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  • Clinical significance of diffuse-type histological type coexistence in Stage II/III gastric cancer Reviewed

    Tanaka Hiroaki, Muguruma Kazuya, Tamura Tatsuro, Toyokawa Takahiro, Shibutani Masatsune, Fukuoka Tatsunari, Nagahara HIsashi, Ohira Masaichi

    CANCER RESEARCH   79 ( 13 )   2019.07( ISSN:0008-5472

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    DOI: 10.1158/1538-7445.AM2019-4876

  • Clinical significance of diffuse-type histological type coexistence in Stage II/III gastric cancer Reviewed

    Tanaka Hiroaki, Muguruma Kazuya, Tamura Tatsuro, Toyokawa Takahiro, Shibutani Masatsune, Fukuoka Tatsunari, Nagahara HIsashi, Ohira Masaichi

    CANCER RESEARCH   79 ( 13 )   2019.07( ISSN:0008-5472

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    DOI: 10.1158/1538-7445.AM2019-4876

  • Prognostic Value of Quality of Life in Endocrine Therapy for Elderly Patients With Breast Cancer: A Retrospective Study Reviewed

    Takada Koji, Kashiwagi Shinichiro, Asano Yuka, Goto Wataru, Takahashi Katsuyuki, Shibutani Masatsune, Amano Ryosuke, Takashima Tsutomu, Tomita Shuhei, Hirakawa Kosei, Ohira Masaichi

    ANTICANCER RESEARCH   39 ( 6 )   2941 - 2950   2019.06( ISSN:0250-7005

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    DOI: 10.21873/anticanres.13424

    PubMed

  • Prognostic Value of Quality of Life in Endocrine Therapy for Elderly Patients With Breast Cancer: A Retrospective Study.

    Takada K, Kashiwagi S, Asano Y, Goto W, Takahashi K, Shibutani M, Amano R, Takashima T, Tomita S, Hirakawa K, Ohira M

    Anticancer research   39 ( 6 )   2941 - 2950   2019.06( ISSN:0250-7005

  • A Case of Tuberculous Peritonitis Diagnosed after Surgery for an Incarcerated Umbilical Hernia Reviewed

    Sugimoto Atsushi, Fukuoka Tatsunari, Maeda Kiyoshi, Nagahara Hisashi, Shibutani Masatsune, Iseki Yasuhito, Matsutani Shinji, Hirakawa Kosei, Ohira Masaichi

    Nihon Fukubu Kyukyu Igakkai Zasshi (Journal of Abdominal Emergency Medicine)   39 ( 4 )   755 - 758   2019.05( ISSN:13402242

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    Publishing type:Research paper (scientific journal)  

    <p>A 68-year-old man, who had uncontrollable ascites and had been treated with diuretics for 6 months, presented with an umbilical bulge and was referred to our hospital for further examination and treatment. Abdominal contrast enhanced computed tomography (CT) revealed a large amount of ascites and a strangulated umbilical hernia involving the small intestine. We performed an emergency operation comprising partial resection of approximately 10 cm of the small intestine and repair of a 3×2 cm hernia orifice with primary closure. There was no peritoneal nodule and ascitic smear, and culture and polymerase chain reaction (PCR) were negative. The levels of adenosine deaminase (ADA) in the ascites was high and the QuantiFERON–TB (QFT) test was positive. We diagnosed the condition as an umbilical hernia due to tuberculous peritonitis. The patient was treated with anti-tuberculous drugs and the ascites disappeared. Tuberculous peritonitis is so rare that it often needs a prolonged examination before diagnosis can be made. Therefore, it may cause secondary acute abdomen require an emergency operation such as in our case. In acute abdomen with refractory ascites, it is important to exam intraoperatively the ascites and peritoneal nodules to arrive at the diagnosis of tuberculous peritonitis.</p>

    DOI: 10.11231/jaem.39.755

    CiNii Article

  • [Efficacy and Safety of Paclitaxel plus Ramucirumab Therapy for Unresectable or Recurrent Gastric Cancer]. Reviewed

    Tsujio G, Toyokawa T, Fukuoka T, Tamura T, Ohira G, Shibutani M, Yamazoe S, Nagahara H, Kimura K, Amano R, Tanaka H, Muguruma K, Yashiro M, Maeda K, Hirakawa K, Ohira M

    Gan to kagaku ryoho. Cancer & chemotherapy   46 ( 5 )   895 - 899   2019.05( ISSN:0385-0684

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    Publishing type:Research paper (scientific journal)  

    PubMed

  • Crohn病に対する単孔式腹腔鏡下手術に関する報告のレビュー(A review of reports on single-incision laparoscopic surgery for Crohn's disease) Reviewed

    Maeda Kiyoshi, Nagahara Hisashi, Shibutani Masatsune, Fukuoka Tatsunari, Inoue Toru, Ohira Masaichi

    シュプリンガー・ジャパン(株) Surgery Today   49 ( 5 )   361 - 368   2019.05( ISSN:0941-1291

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    Publishing type:Research paper (scientific journal)  

    Crohn病(CD)患者への単孔式腹腔鏡下手術(SILS)に関する文献のシステマティックレビューを行い、手術適応、手術手技、実施可能性、有益性について検討した。PubMedおよびMedlineを用いて2010年1月〜2018年7月に出版された論文を検索し、選択基準を満たす論文における患者年齢、性別、BMI、疾患型、SILS手技、手術手技、切開長、手術時間、開腹移行率、術後合併症、死亡率、入院期間、再手術率を評価した。最終的に患者数369例を含む11論文を抽出した。内訳は症例シリーズ2件、症例対照研究9件であった。手術手技と器具のバリエーションは幅広かった。最も多いSILSの手術適応は、回腸末端または上行結腸の狭窄ならびに閉塞で、瘻孔、腹部膿瘍、腫瘤も9例の報告でSILSの適用であった。SILSの平均手術時間は86〜171分、開腹移行率は0〜15.1%、術後合併症率は4.1〜18.8%、再手術率0〜5.9%、入院期間は4〜11日であった。CDに対するSILSの適応または禁忌は明確に定義できなかったが、当該手術はCD患者に対し実施可能かつ安全であることが示唆された。

  • Clinical Outcomes of Recombinant Human-soluble Thrombomodulin Treatment for Disseminated Intravascular Coagulation in Solid Tumors Reviewed

    Kashiwagi Shinichiro, Asano Yuka, Takahashi Katsuyuki, Shibutani Masatsune, Amano Ryosuke, Tomita Shuhei, Hirakawa Kosei, Ohira Masaichi

    ANTICANCER RESEARCH   39 ( 5 )   2259 - 2264   2019.05( ISSN:0250-7005

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.21873/anticanres.13342

    PubMed

  • A review of reports on single-incision laparoscopic surgery for Crohn's disease Reviewed

    Maeda Kiyoshi, Nagahara Hisashi, Shibutani Masatsune, Fukuoka Tatsunari, Inoue Toru, Ohira Masaichi

    SURGERY TODAY   49 ( 5 )   361 - 368   2019.05( ISSN:0941-1291

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00595-018-1732-x

    PubMed

  • Efficacy and safety of Paclitaxel plus ramucirumab therapy for unresectable or recurrent gastric cancer

    Tsujio G.

    Japanese Journal of Cancer and Chemotherapy   46 ( 5 )   895 - 899   2019.05( ISSN:03850684

  • Crohn病に対する単孔式腹腔鏡下手術に関する報告のレビュー(A review of reports on single-incision laparoscopic surgery for Crohn's disease)

    Maeda Kiyoshi, Nagahara Hisashi, Shibutani Masatsune, Fukuoka Tatsunari, Inoue Toru, Ohira Masaichi

    Surgery Today   49 ( 5 )   361 - 368   2019.05( ISSN:0941-1291

     More details

    Crohn病(CD)患者への単孔式腹腔鏡下手術(SILS)に関する文献のシステマティックレビューを行い、手術適応、手術手技、実施可能性、有益性について検討した。PubMedおよびMedlineを用いて2010年1月〜2018年7月に出版された論文を検索し、選択基準を満たす論文における患者年齢、性別、BMI、疾患型、SILS手技、手術手技、切開長、手術時間、開腹移行率、術後合併症、死亡率、入院期間、再手術率を評価した。最終的に患者数369例を含む11論文を抽出した。内訳は症例シリーズ2件、症例対照研究9件であった。手術手技と器具のバリエーションは幅広かった。最も多いSILSの手術適応は、回腸末端または上行結腸の狭窄ならびに閉塞で、瘻孔、腹部膿瘍、腫瘤も9例の報告でSILSの適用であった。SILSの平均手術時間は86〜171分、開腹移行率は0〜15.1%、術後合併症率は4.1〜18.8%、再手術率0〜5.9%、入院期間は4〜11日であった。CDに対するSILSの適応または禁忌は明確に定義できなかったが、当該手術はCD患者に対し実施可能かつ安全であることが示唆された。

  • Crohn病に対する単孔式腹腔鏡下手術に関する報告のレビュー(A review of reports on single-incision laparoscopic surgery for Crohn's disease) Reviewed

    Maeda Kiyoshi, Nagahara Hisashi, Shibutani Masatsune, Fukuoka Tatsunari, Inoue Toru, Ohira Masaichi

    シュプリンガー・ジャパン(株) Surgery Today   49 ( 5 )   361 - 368   2019.05( ISSN:0941-1291

     More details

    Publishing type:Research paper (scientific journal)  

    Crohn病(CD)患者への単孔式腹腔鏡下手術(SILS)に関する文献のシステマティックレビューを行い、手術適応、手術手技、実施可能性、有益性について検討した。PubMedおよびMedlineを用いて2010年1月〜2018年7月に出版された論文を検索し、選択基準を満たす論文における患者年齢、性別、BMI、疾患型、SILS手技、手術手技、切開長、手術時間、開腹移行率、術後合併症、死亡率、入院期間、再手術率を評価した。最終的に患者数369例を含む11論文を抽出した。内訳は症例シリーズ2件、症例対照研究9件であった。手術手技と器具のバリエーションは幅広かった。最も多いSILSの手術適応は、回腸末端または上行結腸の狭窄ならびに閉塞で、瘻孔、腹部膿瘍、腫瘤も9例の報告でSILSの適用であった。SILSの平均手術時間は86〜171分、開腹移行率は0〜15.1%、術後合併症率は4.1〜18.8%、再手術率0〜5.9%、入院期間は4〜11日であった。CDに対するSILSの適応または禁忌は明確に定義できなかったが、当該手術はCD患者に対し実施可能かつ安全であることが示唆された。

  • Clinical Outcomes of Recombinant Human-soluble Thrombomodulin Treatment for Disseminated Intravascular Coagulation in Solid Tumors.

    Kashiwagi S, Asano Y, Takahashi K, Shibutani M, Amano R, Tomita S, Hirakawa K, Ohira M

    Anticancer research   39 ( 5 )   2259 - 2264   2019.05( ISSN:0250-7005

  • A review of reports on single-incision laparoscopic surgery for Crohn's disease Reviewed

    Maeda Kiyoshi, Nagahara Hisashi, Shibutani Masatsune, Fukuoka Tatsunari, Inoue Toru, Ohira Masaichi

    SURGERY TODAY   49 ( 5 )   361 - 368   2019.05( ISSN:0941-1291

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00595-018-1732-x

    PubMed

  • [Efficacy and Safety of Paclitaxel plus Ramucirumab Therapy for Unresectable or Recurrent Gastric Cancer]. Reviewed

    Tsujio G, Toyokawa T, Fukuoka T, Tamura T, Ohira G, Shibutani M, Yamazoe S, Nagahara H, Kimura K, Amano R, Tanaka H, Muguruma K, Yashiro M, Maeda K, Hirakawa K, Ohira M

    Gan to kagaku ryoho. Cancer & chemotherapy   46 ( 5 )   895 - 899   2019.05( ISSN:0385-0684

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    Publishing type:Research paper (scientific journal)  

  • [Efficacy and Safety of Paclitaxel plus Ramucirumab Therapy for Unresectable or Recurrent Gastric Cancer].

    Tsujio G, Toyokawa T, Fukuoka T, Tamura T, Ohira G, Shibutani M, Yamazoe S, Nagahara H, Kimura K, Amano R, Tanaka H, Muguruma K, Yashiro M, Maeda K, Hirakawa K, Ohira M

    Gan to kagaku ryoho. Cancer & chemotherapy   46 ( 5 )   895 - 899   2019.05( ISSN:0385-0684

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  • The prognostic significance of the advanced lung cancer inflammation index in patients with unresectable metastatic colorectal cancer: a retrospective study Reviewed

    Shibutani Masatsune, Maeda Kiyoshi, Nagahara Hisashi, Fukuoka Tatsunari, Matsutani Shinji, Kimura Kenjiro, Amano Ryosuke, Hirakawa Kosei, Ohira Masaichi

    BMC CANCER   19 ( 1 )   241   2019.03

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s12885-019-5468-9

    PubMed

  • The prognostic significance of the advanced lung cancer inflammation index in patients with unresectable metastatic colorectal cancer: a retrospective study Reviewed

    Shibutani Masatsune, Maeda Kiyoshi, Nagahara Hisashi, Fukuoka Tatsunari, Matsutani Shinji, Kimura Kenjiro, Amano Ryosuke, Hirakawa Kosei, Ohira Masaichi

    BMC CANCER   19 ( 1 )   241   2019.03

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s12885-019-5468-9

    PubMed

  • Prognostic Significance of the C-Reactive Protein-to-Albumin Ratio in Patients With Metastatic Colorectal Cancer Treated With Trifluridine/Thymidine Phosphorylase Inhibitor as Later-line Chemotherapy Reviewed

    Shibutani Masatsune, Nagahara Hisashi, Fukuoka Tatsunari, Iseki Yasuhito, Matsutani Shinji, Wang En, Maeda Kiyoshi, Hirakawa Kosei, Ohira Masaichi

    ANTICANCER RESEARCH   39 ( 2 )   1051 - 1057   2019.02( ISSN:0250-7005

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.21873/anticanres.13212

    PubMed

  • Impact of the occurrence of new lesions on the survival of patients who undergo chemotherapy for metastatic colorectal cancer Reviewed

    Shibutani Masatsune, Maeda Kiyoshi, Nagahara Hisashi, Fukuoka Tatsunari, Matsutani Shinji, Kashiwagi Shinichiro, Hirakawa Kosei, Ohira Masaichi

    MOLECULAR AND CLINICAL ONCOLOGY   10 ( 2 )   285 - 292   2019.02( ISSN:2049-9450

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.3892/mco.2018.1778

    PubMed

  • Impact of the occurrence of new lesions on the survival of patients who undergo chemotherapy for metastatic colorectal cancer Reviewed

    Shibutani Masatsune, Maeda Kiyoshi, Nagahara Hisashi, Fukuoka Tatsunari, Matsutani Shinji, Kashiwagi Shinichiro, Hirakawa Kosei, Ohira Masaichi

    MOLECULAR AND CLINICAL ONCOLOGY   10 ( 2 )   285 - 292   2019.02( ISSN:2049-9450

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.3892/mco.2018.1778

    PubMed

  • A Case of Tuberculous Peritonitis Diagnosed after Surgery for an Incarcerated Umbilical Hernia Reviewed

    Sugimoto Atsushi, Fukuoka Tatsunari, Maeda Kiyoshi, Nagahara Hisashi, Shibutani Masatsune, Iseki Yasuhito, Matsutani Shinji, Hirakawa Kosei, Ohira Masaichi

    Japanese Society for Abdominal Emergency Medicine, Nihon Fukubu Kyukyu Igakkai Zasshi (Journal of Abdominal Emergency Medicine)   39 ( 4 )   755 - 758   2019( ISSN:1340-2242

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    Publishing type:Research paper (scientific journal)  

    <p>A 68-year-old man, who had uncontrollable ascites and had been treated with diuretics for 6 months, presented with an umbilical bulge and was referred to our hospital for further examination and treatment. Abdominal contrast enhanced computed tomography (CT) revealed a large amount of ascites and a strangulated umbilical hernia involving the small intestine. We performed an emergency operation comprising partial resection of approximately 10 cm of the small intestine and repair of a 3×2 cm hernia orifice with primary closure. There was no peritoneal nodule and ascitic smear, and culture and polymerase chain reaction (PCR) were negative. The levels of adenosine deaminase (ADA) in the ascites was high and the QuantiFERON–TB (QFT) test was positive. We diagnosed the condition as an umbilical hernia due to tuberculous peritonitis. The patient was treated with anti-tuberculous drugs and the ascites disappeared. Tuberculous peritonitis is so rare that it often needs a prolonged examination before diagnosis can be made. Therefore, it may cause secondary acute abdomen require an emergency operation such as in our case. In acute abdomen with refractory ascites, it is important to exam intraoperatively the ascites and peritoneal nodules to arrive at the diagnosis of tuberculous peritonitis.</p>

    DOI: 10.11231/jaem.39.755

    CiNii Article

  • Danaparoid Sodium Effectively Treats Portal Vein Thrombosis after Laparoscopic Intersphincteric Resection for Rectal Cancer—A Case Report— Reviewed

    SUGIMOTO Atsushi, FUKUOKA Tatsunari, NAGAHARA Hisashi, SHIBUTANI Masatsune, ISEKI Yasuhito, OHIRA Masaichi

    Japan Surgical Association, Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association)   80 ( 8 )   1508 - 1512   2019( ISSN:1345-2843

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    Publishing type:Research paper (scientific journal)  

    <p>Portal vein thrombosis after laparoscopic colorectal cancer surgery is rare. To date, no reliable criteria are available regarding the optimal anticoagulant and its duration of administration in such cases. We report a case of portal vein thrombosis successfully treated with danaparoid sodium in a patient who underwent laparoscopic surgery for rectal cancer. A 59-year-old man underwent laparoscopic intersphincteric resection and ileostomy for lower rectal cancer (pT1a, N0, M0, pStage 0). Laboratory tests performed on the 29<sup>th</sup> postoperative day revealed mild liver dysfunction. Abdominal ultrasonography and contrast-enhanced computed tomography revealed portal vein thrombosis in the umbilical portion. Complete resolution of the thrombus was observed following 2-week treatment with danaparoid sodium. We had treated the patient with warfarin for 8 weeks, and no recurrence of thrombus was observed. We concluded that thrombosis was attributable to a combination of reduced blood flow through the portal vein secondary to elevated intra-abdominal pressure, carbon dioxide pneumoperitoneum, and the Trendelenburg position used during laparoscopic surgery. Danaparoid sodium effectively treats portal vein thrombosis observed after laparoscopic surgery for colorectal cancer.</p>

    DOI: 10.3919/jjsa.80.1508

    CiNii Article

  • A Case of Invagination due to Small Intestinal Metastasis from a Renal Cell Carcinoma

    Natsuki Seiji, Iseki Yasuhito, Nagahara Hisashi, Fukuoka Tatsunari, Shibutani Masatsune, Ohira Masaichi

    Nihon Gekakei Rengo Gakkaishi (Journal of Japanese College of Surgeons)   44 ( 5 )   921 - 925   2019( ISSN:03857883

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    <p>A 71-years-old man underwent left nephrectomy and received chemotherapy for multiple metastases, in the lung, bone, and skin. He was admitted with vomiting and abdominal distension. Abdominal computed tomography (CT) revealed invagination and small intestine obstruction, and intestinal metastasis from his renal cell carcinoma (RCC) was suspected. We performed surgery after improving the intestinal distension with an ileus tube. A tumor was observed in the ileum 90 cm upstream from the ileocecal valve with anterograde invagination. We partially resected the small intestine together with the tumor, which was pathologically diagnosed as a clear cell carcinoma that metastasized from the RCC. Metastasis of RCC to the small intestine is a rare entity clinically. We report this case with other cases of small intestinal metastasis we have experienced.</p>

    DOI: 10.4030/jjcs.44.921

    CiNii Article

  • Danaparoid Sodium Effectively Treats Portal Vein Thrombosis after Laparoscopic Intersphincteric Resection for Rectal Cancer—A Case Report—

    SUGIMOTO Atsushi, FUKUOKA Tatsunari, NAGAHARA Hisashi, SHIBUTANI Masatsune, ISEKI Yasuhito, OHIRA Masaichi

    Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association)   80 ( 8 )   1508 - 1512   2019( ISSN:13452843

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    Publishing type:Research paper (scientific journal)  

    <p>Portal vein thrombosis after laparoscopic colorectal cancer surgery is rare. To date, no reliable criteria are available regarding the optimal anticoagulant and its duration of administration in such cases. We report a case of portal vein thrombosis successfully treated with danaparoid sodium in a patient who underwent laparoscopic surgery for rectal cancer. A 59-year-old man underwent laparoscopic intersphincteric resection and ileostomy for lower rectal cancer (pT1a, N0, M0, pStage 0). Laboratory tests performed on the 29<sup>th</sup> postoperative day revealed mild liver dysfunction. Abdominal ultrasonography and contrast-enhanced computed tomography revealed portal vein thrombosis in the umbilical portion. Complete resolution of the thrombus was observed following 2-week treatment with danaparoid sodium. We had treated the patient with warfarin for 8 weeks, and no recurrence of thrombus was observed. We concluded that thrombosis was attributable to a combination of reduced blood flow through the portal vein secondary to elevated intra-abdominal pressure, carbon dioxide pneumoperitoneum, and the Trendelenburg position used during laparoscopic surgery. Danaparoid sodium effectively treats portal vein thrombosis observed after laparoscopic surgery for colorectal cancer.</p>

    DOI: 10.3919/jjsa.80.1508

    CiNii Article

  • [A Case of Appendiceal Cancer Wherein the Abdominal Abscess Ruptured into the Urinary Bladder Owing to Obstructive Appendicitis]. Reviewed

    Tsujio G, Nagahara H, Shibutani M, Fukuoka T, Matsutani S, Kusunoki C, Yamazoe S, Kimura K, Toyokawa T, Amano R, Tanaka H, Muguruma K, Yashiro M, Hirakawa K, Ohira M

    Gan to kagaku ryoho. Cancer & chemotherapy   45 ( 13 )   2458 - 2460   2018.12( ISSN:0385-0684

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    Publishing type:Research paper (scientific journal)  

    PubMed

  • Tumor-infiltrating Immune Cells in H&E-stained Sections of Colorectal Cancer Tissue as a Reasonable Immunological Biomarker Reviewed

    Matsutani Shinji, Shibutani Masatsune, Maeda Kiyoshi, Nagahara Hisashi, Fukuoka Tatsunari, Iseki Yasuhito, Kashiwagi Shinichiro, Tanaka Hiroaki, Hirakawa Kosei, Ohira Masaichi

    ANTICANCER RESEARCH   38 ( 12 )   6721 - 6727   2018.12( ISSN:0250-7005

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.21873/anticanres.13041

    PubMed

  • The reasonability of the density of immune cells in H&E sections of colorectal cancer as the the immunological biomarker Reviewed

    Matsutani Shinji, Shibutani Masatsune, Maeda Kiyoshi, Nagahara Hisashi, Fukuoka Tatsunari, Iseki Yasuhito, Kashiwagi Shinichiro, Toyokawa Takahiro, Amano Ryosuke, Tanaka Hiroaki, Muguruma Kazuya, Hirakawa Kosei, Ohira Masaichi

    CANCER SCIENCE   109   1332 - 1332   2018.12( ISSN:1349-7006

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  • Clinical significance of diffuse-type histologic type coexistence in gastric cancer Reviewed

    Tanaka Hiroaki, Muguruma Kazuya, Tamura Tatsuro, Toyokawa Takahiro, Shibutani Masatsune, Nagahara Hisashi, Yashiro Masakazu, Hirakawa Kosei, Ohira Masaichi

    CANCER SCIENCE   109   479 - 479   2018.12( ISSN:1349-7006

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  • [A Case of Appendiceal Cancer Wherein the Abdominal Abscess Ruptured into the Urinary Bladder Owing to Obstructive Appendicitis].

    Tsujio G, Nagahara H, Shibutani M, Fukuoka T, Matsutani S, Kusunoki C, Yamazoe S, Kimura K, Toyokawa T, Amano R, Tanaka H, Muguruma K, Yashiro M, Hirakawa K, Ohira M

    Gan to kagaku ryoho. Cancer & chemotherapy   45 ( 13 )   2458 - 2460   2018.12( ISSN:0385-0684

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  • Clinical significance of diffuse-type histologic type coexistence in gastric cancer Reviewed

    Tanaka Hiroaki, Muguruma Kazuya, Tamura Tatsuro, Toyokawa Takahiro, Shibutani Masatsune, Nagahara Hisashi, Yashiro Masakazu, Hirakawa Kosei, Ohira Masaichi

    CANCER SCIENCE   109   479 - 479   2018.12( ISSN:1349-7006

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    Publishing type:Research paper (scientific journal)  

  • [A Case of Appendiceal Cancer Wherein the Abdominal Abscess Ruptured into the Urinary Bladder Owing to Obstructive Appendicitis]. Reviewed

    Tsujio G, Nagahara H, Shibutani M, Fukuoka T, Matsutani S, Kusunoki C, Yamazoe S, Kimura K, Toyokawa T, Amano R, Tanaka H, Muguruma K, Yashiro M, Hirakawa K, Ohira M

    Gan to kagaku ryoho. Cancer & chemotherapy   45 ( 13 )   2458 - 2460   2018.12( ISSN:0385-0684

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    Publishing type:Research paper (scientific journal)  

  • The reasonability of the density of immune cells in H&E sections of colorectal cancer as the the immunological biomarker Reviewed

    Matsutani Shinji, Shibutani Masatsune, Maeda Kiyoshi, Nagahara Hisashi, Fukuoka Tatsunari, Iseki Yasuhito, Kashiwagi Shinichiro, Toyokawa Takahiro, Amano Ryosuke, Tanaka Hiroaki, Muguruma Kazuya, Hirakawa Kosei, Ohira Masaichi

    CANCER SCIENCE   109   1332 - 1332   2018.12( ISSN:1349-7006

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  • Tumor-infiltrating Immune Cells in H&E-stained Sections of Colorectal Cancer Tissue as a Reasonable Immunological Biomarker Reviewed

    Matsutani Shinji, Shibutani Masatsune, Maeda Kiyoshi, Nagahara Hisashi, Fukuoka Tatsunari, Iseki Yasuhito, Kashiwagi Shinichiro, Tanaka Hiroaki, Hirakawa Kosei, Ohira Masaichi

    ANTICANCER RESEARCH   38 ( 12 )   6721 - 6727   2018.12( ISSN:0250-7005

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.21873/anticanres.13041

    PubMed

  • A Case of a Metastatic Tumor of Small Intestine Originating From an Angiosarcoma of the Head Reviewed

    Eguchi Shinpei, Maeda Kiyoshi, Nakao Shigetomi, Shibutani Masatsune, Nagahara Hisashi, Muguruma Kazuya, Toyokawa Takahiro, Hirakawa Kousei, Ohira Masaichi

    Nihon Fukubu Kyukyu Igakkai Zasshi (Journal of Abdominal Emergency Medicine)   38 ( 7 )   1209 - 1212   2018.11( ISSN:13402242

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    <p>The patient was a 67-year-old male. He presented with abdominal distention and pain during radiotherapy for a cutaneous angiosarcoma of the head at our dermatology department. An abdominal CT scan showed thickening of the ileum wall and dilatation of the proximal small bowel extending from the thickened section. He was diagnosed as having bowel obstruction. Conservative treatment was then performed with an intestinal tube ; however, he subsequently underwent surgery because no improvement was observed. Laparoscopic observation of the abdominal cavity revealed an approximately 5-cm, dark red tumor in the ileum with dilatation of the proximal small bowel. Thus, this site was considered to be the origin of obstruction. The small bowel was partially resected through a minilaparotomy. The patient was diagnosed as having small bowel metastasis from a cutaneous angiosarcoma of the head based on the results of the histopathological tests. Small bowel metastasis from angiosarcomas is rare ; thus, we report on our case along with a review of the relevant literature.</p>

    DOI: 10.11231/jaem.38.1209

    CiNii Article

  • Two Cases of Long-Term Control of Metastatic Colorectal Cancer via FTD/TPI plus Bevacizumab in Elderly Patients Reviewed

    Shibutani Masatsune, Maeda Kiyoshi, Nagahara Hisashi, Fukuoka Tatsunari, Iseki Yasuhito, Matsutani Shinji, Wang En, Hirakawa Kosei, Ohira Masaichi

    CASE REPORTS IN ONCOLOGY   11 ( 3 )   800 - 805   2018.09( ISSN:1662-6575

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    DOI: 10.1159/000493849

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  • Neoadjuvant Radiotherapy with Capecitabine Plus Bevacizumab for Locally Advanced Lower Rectal Cancer: Results of a Single-institute Phase II Study Reviewed

    Maeda Kiyoshi, Shibutani Masatsune, Otani Hiroshi, Fukuoka Tatsunari, Iseki Yasuhito, Matsutani Shinji, Nagahara Hisashi, Inoue Toru, Tachimori Akiko, Nishii Takafumi, Miki Yoshitaka, Hosono Masako, Ohira Masaichi

    ANTICANCER RESEARCH   38 ( 7 )   4193 - 4197   2018.07( ISSN:0250-7005

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    DOI: 10.21873/anticanres.12713

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  • Verification of the methodology for evaluating tumor-infiltrating lymphocytes in colorectal cancer Reviewed

    Matsutani Shinji, Shibutani Masatsune, Maeda Kiyoshi, Nagahara Hisashi, Fukuoka Tatsunari, Tamura Tatsuro, Ohira Go, Yamazoe Sadaaki, Kimura Kenjiro, Toyokawa Takahiro, Amano Ryosuke, Tanaka Hiroaki, Muguruma Kazuya, Hirakawa Kosei, Ohira Masaichi

    CANCER RESEARCH   78 ( 13 )   2018.07( ISSN:0008-5472

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    DOI: 10.1158/1538-7445.AM2018-5701

  • The prognostic value of the systemic inflammatory score in patients with unresectable metastatic colorectal cancer Reviewed

    Shibutani Masatsune, Maeda Kiyoshi, Nagahara Hisashi, Fukuoka Tatsunari, Matsutani Shinji, Kimura Kenjiro, Amano Ryosuke, Hirakawa Kosei, Ohira Masaichi

    ONCOLOGY LETTERS   16 ( 1 )   666 - 672   2018.07( ISSN:1792-1074

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    DOI: 10.3892/ol.2018.8628

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  • Neoadjuvant Radiotherapy with Capecitabine Plus Bevacizumab for Locally Advanced Lower Rectal Cancer: Results of a Single-institute Phase II Study Reviewed

    Maeda Kiyoshi, Shibutani Masatsune, Otani Hiroshi, Fukuoka Tatsunari, Iseki Yasuhito, Matsutani Shinji, Nagahara Hisashi, Inoue Toru, Tachimori Akiko, Nishii Takafumi, Miki Yoshitaka, Hosono Masako, Ohira Masaichi

    ANTICANCER RESEARCH   38 ( 7 )   4193 - 4197   2018.07( ISSN:0250-7005

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    DOI: 10.21873/anticanres.12713

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  • The prognostic value of the systemic inflammatory score in patients with unresectable metastatic colorectal cancer Reviewed

    Shibutani Masatsune, Maeda Kiyoshi, Nagahara Hisashi, Fukuoka Tatsunari, Matsutani Shinji, Kimura Kenjiro, Amano Ryosuke, Hirakawa Kosei, Ohira Masaichi

    ONCOLOGY LETTERS   16 ( 1 )   666 - 672   2018.07( ISSN:1792-1074

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    DOI: 10.3892/ol.2018.8628

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  • Verification of the methodology for evaluating tumor-infiltrating lymphocytes in colorectal cancer Reviewed

    Matsutani Shinji, Shibutani Masatsune, Maeda Kiyoshi, Nagahara Hisashi, Fukuoka Tatsunari, Tamura Tatsuro, Ohira Go, Yamazoe Sadaaki, Kimura Kenjiro, Toyokawa Takahiro, Amano Ryosuke, Tanaka Hiroaki, Muguruma Kazuya, Hirakawa Kosei, Ohira Masaichi

    CANCER RESEARCH   78 ( 13 )   2018.07( ISSN:0008-5472

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    DOI: 10.1158/1538-7445.AM2018-5701

  • Meta-analysis of robot-assisted versus laparoscopic surgery for rectal cancer Reviewed

    Hiroshi Ohtani, Kiyoshi Maeda, Shinya Nomura, Osamu Shinto, Yoko Mizuyama, Hiroji Nakagawa, Hisashi Nagahara, Masatsune Shibutani, Tatsunari Fukuoka, Ryosuke Amano, Kosei Hirakawa, Masaichi Ohira

    In Vivo   32 ( 3 )   611 - 623   2018.05( ISSN:0258-851X

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    Background/Aim: A meta-analysis was conducted to evaluate and compare the short- and long-term outcomes of robot-assisted (RAS) and conventional laparoscopic surgery (LAS) for rectal cancer. Materials and Methods: We searched MEDLINE for relevant papers published between 2010 and December 2017 by using specific search terms. We analyzed outcomes over short- and long-term periods. Results: We identified 23 papers reporting results that compared RAS for rectal cancer with LAS. Our meta-analysis included 4,348 patients with rectal cancer
    2,068 had undergone RAS, and 2,280 had undergone LAS. In the short- and long-term period, 27 and 7 outcome variables were examined, respectively. RAS for rectal cancer was significantly associated with a greater operative time and a lower conversion rate to open surgery in the short-term, and results in almost similar outcomes in the long-term, compared to LAS. Conclusion: RAS may be an acceptable surgical treatment option compared to LAS for rectal cancer.

    DOI: 10.21873/invivo.11283

    PubMed

  • Complete Response of Pulmonary Metastases from Rectal Cancer to Tegafur-Uracil/Leucovorin plus Bevacizumab in an Elderly Patient: A Case Report Reviewed

    Shibutani Masatsune, Maeda Kiyoshi, Nagahara Hisashi, Fukuoka Tatsunari, Iseki Yasuhito, Matsutani Shinji, Wang En, Hirakawa Kosei, Ohira Masaichi

    CASE REPORTS IN ONCOLOGY   11 ( 2 )   461 - 466   2018.05( ISSN:1662-6575

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    DOI: 10.1159/000490698

    PubMed

  • A new method for evaluating tumor-infiltrating lymphocytes (TILs) in colorectal cancer using hematoxylin and eosin (H-E)-stained tumor sections Reviewed

    Iseki Yasuhito, Shibutani Masatsune, Maeda Kiyoshi, Nagahara Hisashi, Fukuoka Tatsunari, Matsutani Shinji, Kashiwagi Shinichiro, Tanaka Hiroaki, Hirakawa Kosei, Ohira Masaichi

    PLOS ONE   13 ( 4 )   e0192744   2018.04( ISSN:1932-6203

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    DOI: 10.1371/journal.pone.0192744

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  • A comparison of the local immune status between the primary and metastatic tumor in colorectal cancer: a retrospective study Reviewed

    Shibutani Masatsune, Maeda Kiyoshi, Nagahara Hisashi, Fukuoka Tatsunari, Matsutani Shinji, Kashiwagi Shinichiro, Tanaka Hiroaki, Hirakawa Kosei, Ohira Masaichi

    BMC CANCER   18 ( 1 )   371   2018.04( ISSN:1471-2407

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s12885-018-4276-y

    PubMed

  • A comparison of the local immune status between the primary and metastatic tumor in colorectal cancer: A retrospective study Reviewed

    Masatsune Shibutani, Kiyoshi Maeda, Hisashi Nagahara, Tatsunari Fukuoka, Shinji Matsutani, Shinichiro Kashiwagi, Hiroaki Tanaka, Kosei Hirakawa, Masaichi Ohira

    BMC Cancer   18 ( 1 )   371   2018.04( ISSN:1471-2407

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    Background: The anticancer immune response has been reported to correlate with cancer progression. Tumor-infiltrating lymphocytes (TILs), which are one of the indicators of host immunity, affect the tumor growth, metastasis and chemoresistance. Both TILs in the primary tumor and those in the metastatic tumor have been reported to be a useful predictor of the survival and therapeutic outcome. However, the correlation between the density of TILs in the primary and metastatic tumor is unclear. The aim of this study was to elucidate the correlation between the density of TILs in the primary and metastatic tumor. Methods: A total of 24 patients with stage IV colorectal cancer who underwent concurrent resection of the primary tumor and liver metastasis were enrolled in order to assess the correlation between the density of TILs in the primary tumor and that in the metastatic tumor. Hematoxylin and eosin (HE)-stained tumor sections were used for the evaluation of TILs. The density of TILs was assessed by the measurement of the area occupied by mononuclear inflammatory cells over the total stromal area at the invasive margin. In addition, to evaluate TIL subsets and the activation/suppression status of the lymphocytes, immunohistochemistry for CD4, CD8, Forkhead boxprotein P3 (FOXP3), programmed cell death 1 (PD-1), cytotoxic T-lymphocyte-associated protein 4 (CTLA4), inducible T-cell co-stimulator (ICOS), Glucocorticoid induced tumor necrosis factor receptor related protein (GITR), Human Leukocyte Antigen - antigen D Related (HLA-DR) and Granzyme B was performed, and the number of immunoreactive lymphocytes was counted. Results: According to the evaluation using the HE-stained sections, the density of tumor-infiltrating mononuclear inflammatory cells in the primary tumor was significantly associated with that in the metastatic tumor. In addition, according to the immunohistochemistry evaluation, the density of CD4+, CD8+ and FOXP3+ TILs in the primary tumor and that in the metastatic tumor were significantly correlated with that in the metastatic tumor. Furthermore, the activation/suppression marker values of the lymphocytes (i.e., such as PD-1, ICOS, Granzyme B and the PD-1/CD8 ratio) in the primary tumor were correlated with values in the metastatic tumor. Conclusions: The local immune status of the primary tumor was revealed to be similar to that of the metastatic tumor. This suggests that the evaluation of the local immunity of the primary tumor may be a substitute for the evaluation of the local immunity of the metastatic lesion. Therefore, information on the primary tumor may be useful when considering treatment strategies for metastatic lesions.

    DOI: 10.1186/s12885-018-4276-y

    PubMed

  • MicroRNA-96 Promotes Tumor Invasion in Colorectal Cancer via RECK Reviewed

    Iseki Yasuhito, Shibutani Masatsune, Maeda Kiyoshi, Nagahara Hisashi, Fukuoka Tatsunari, Matsutani Shinji, Hirakawa Kosei, Ohira Masaichi

    ANTICANCER RESEARCH   38 ( 4 )   2031 - 2035   2018.04( ISSN:0250-7005

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    DOI: 10.21873/anticanres.12442

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  • 直腸癌に対する術前補助療法前後での腫瘍浸潤リンパ球の重要性(Significance of tumor-infiltrating lymphocytes before and after neoadjuvant therapy for rectal cancer) Reviewed

    Matsutani Shinji, Shibutani Masatsune, Maeda Kiyoshi, Nagahara Hisashi, Fukuoka Tatsunari, Nakao Shigetomi, Hirakawa Kosei, Ohira Masaichi

    John Wiley & Sons Australia, Ltd Cancer Science   109 ( 4 )   966 - 979   2018.04( ISSN:1347-9032

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    局所進行性直腸癌患者を対象に、術前補助療法前後の腫瘍浸潤リンパ球(TIL)の密度を比較した。対象は、術前補助療法後(化学療法[CT]または放射線化学療法[CRT])に切除術を行った直腸癌患者64例(男性44例、女性20例、中央値66歳)で、術前補助療法前の生検検体と補助療法後の切除組織を用いてTILの密度を調べた。TILの評価は免疫組織化学染色により行った。術前にCTを実施した対象およびCRTを実施した対象の両方において、治療前の生検検体のCD8+TILの密度が低かった場合、治療への反応が悪い傾向にあった。切除組織におけるCD8+TILの低密度も同様に治療への反応性の低さと関連していた。またCRTを行った群では、CD8+TILの密度が治療後に有意に上昇していた。以上より、直腸癌においてTリンパ球に関連した免疫応答が術前補助療法への反応性に重要な役割を果たしており、療法実施前に生検検体のTILを評価することで治療効果を予測できる可能性が示された。

  • Significance of tumor-infiltrating lymphocytes before and after neoadjuvant therapy for rectal cancer Reviewed

    Matsutani Shinji, Shibutani Masatsune, Maeda Kiyoshi, Nagahara Hisashi, Fukuoka Tatsunari, Nakao Shigetomi, Hirakawa Kosei, Ohira Masaichi

    CANCER SCIENCE   109 ( 4 )   966 - 979   2018.04( ISSN:1349-7006

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    DOI: 10.1111/cas.13542

    PubMed

  • 直腸癌に対する術前補助療法前後での腫瘍浸潤リンパ球の重要性(Significance of tumor-infiltrating lymphocytes before and after neoadjuvant therapy for rectal cancer)

    Matsutani Shinji, Shibutani Masatsune, Maeda Kiyoshi, Nagahara Hisashi, Fukuoka Tatsunari, Nakao Shigetomi, Hirakawa Kosei, Ohira Masaichi

    Cancer Science   109 ( 4 )   966 - 979   2018.04( ISSN:1347-9032

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    局所進行性直腸癌患者を対象に、術前補助療法前後の腫瘍浸潤リンパ球(TIL)の密度を比較した。対象は、術前補助療法後(化学療法[CT]または放射線化学療法[CRT])に切除術を行った直腸癌患者64例(男性44例、女性20例、中央値66歳)で、術前補助療法前の生検検体と補助療法後の切除組織を用いてTILの密度を調べた。TILの評価は免疫組織化学染色により行った。術前にCTを実施した対象およびCRTを実施した対象の両方において、治療前の生検検体のCD8+TILの密度が低かった場合、治療への反応が悪い傾向にあった。切除組織におけるCD8+TILの低密度も同様に治療への反応性の低さと関連していた。またCRTを行った群では、CD8+TILの密度が治療後に有意に上昇していた。以上より、直腸癌においてTリンパ球に関連した免疫応答が術前補助療法への反応性に重要な役割を果たしており、療法実施前に生検検体のTILを評価することで治療効果を予測できる可能性が示された。

  • MicroRNA-96 promotes tumor invasion in colorectal cancer via RECK Reviewed

    Yasuhito Iseki, Masatsune Shibutani, Kiyoshi Maeda, Hisashi Nagahara, Tatsunari Fukuoka, Shinji Matsutani, Kosei Hirakawa, Masaichi Ohira

    Anticancer Research   38 ( 4 )   2031 - 2035   2018.04( ISSN:0250-7005

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    Background: miR-96 is reported to inhibit reversion cysteine-rich Kazal motif (RECK), which is associated with tumor invasion, in solid cancer types (e.g. breast cancer, non-small cell lung cancer, esophageal cancer). The purpose of this study is to clarify whether miR-96 is similarly associated with tumor invasion in colorectal cancer. Materials and Methods: We performed western blotting to investigate the expression of RECK when miR-96 mimics or inhibitors were transferred into HCT-116 colorectal cancer cells. The RECK mRNA level was assessed by a reverse transcription polymerase chain reaction. An invasion assay was used to evaluate tumor invasion. Results: The expression of RECK was inhibited by the transfection of miR-96 mimics. RECK mRNA level was reduced by miR-96 mimics and increased by miR-96 inhibitor. In the invasion assay, miR-96 mimics were shown to promote tumor invasion. Conclusion: miR-96 may be associated with tumor invasion through inhibition of RECK expression in colorectal cancer.

    DOI: 10.21873/anticanres.12442

    PubMed

  • Significance of tumor-infiltrating lymphocytes before and after neoadjuvant therapy for rectal cancer Reviewed

    Shinji Matsutani, Masatsune Shibutani, Kiyoshi Maeda, Hisashi Nagahara, Tatsunari Fukuoka, Shigetomi Nakao, Kosei Hirakawa, Masaichi Ohira

    Cancer Science   109 ( 4 )   966 - 979   2018.04( ISSN:1347-9032

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    Neoadjuvant therapy for locally advanced rectal cancer is becoming increasingly common. However, biomarkers predicting the response to neoadjuvant therapy have not been established. Tumor-infiltrating lymphocytes (TILs) have a crucial effect on tumor progression and survival outcome as the primary host immune response, and an antitumor immune effect has been reported to contribute to the response to radiotherapy and chemotherapy. We investigated the significance of TILs before and after neoadjuvant treatment and the change in the density of those TILs. Sixty-four patients who underwent radical resection after neoadjuvant treatment for locally advanced rectal cancer were enrolled. The number of TIL subsets was examined using immunohistochemical staining of pretreatment biopsy samples and post-treatment resected specimens. In both the neoadjuvant chemotherapy cohort and the neoadjuvant chemoradiotherapy cohort, a low density of CD8+ TILs in pretreatment biopsy samples was associated with a poor response, and a low density of CD8+ TILs in post-treatment resected specimens was similarly associated with a poor response. In the neoadjuvant chemoradiotherapy cohort, the density of CD8+ TILs in post-treatment resected specimens was significantly increased compared with that in pretreatment biopsy samples. We concluded that T lymphocyte-mediated immune reactions play an important role in tumor response to neoadjuvant treatment for rectal cancer, and the evaluation of TILs in pretreatment biopsy samples might be a predictor of the clinical effectiveness of neoadjuvant treatment. Furthermore, neoadjuvant therapy, especially chemoradiotherapy, could induce the activation of the local immune status.

    DOI: 10.1111/cas.13542

    PubMed

  • Verification of the methodology for evaluating tumor-infiltrating lymphocytes in colorectal cancer. Reviewed

    Matsutani S, Shibutani M, Maeda K, Nagahara H, Fukuoka T, Iseki Y, Hirakawa K, Ohira M

    Oncotarget   9 ( 20 )   15180 - 15197   2018.03

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    DOI: 10.18632/oncotarget.24612

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  • Verification of the methodology for evaluating tumor-infiltrating lymphocytes in colorectal cancer Reviewed

    Shinji Matsutani, Masatsune Shibutani, Kiyoshi Maeda, Hisashi Nagahara, Tatsunari Fukuoka, Yasuhito Iseki, Kosei Hirakawa, Masaichi Ohira

    Oncotarget   9 ( 20 )   15180 - 15197   2018.03( ISSN:1949-2553

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    Background: The density of tumor-infiltrating lymphocytes (TILs) have been reported to reflect antitumor immune response and correlate with prognosis in malignancy. However, the methodology for evaluating the density of TILs by an immunohistochemical analysis differs among reports. The aim of this study was to verify the methodology for evaluating the density of TILs by immunohistochemical analysis and thereby identify the optimum methodology in clinical setting. Methods: Three-hundred-thirteen patients who underwent curative operation for stage II/III colorectal cancer were enrolled. We retrospectively examined the density of TILs using immunohistochemical staining according to each method as follows: 1) subset of lymphocytes (i.e. CD4+/CD8+), 2) selected fields (i.e. at random or focusing on hot spots), 3) location in low-power field (i.e. the invasive margin [TILsIM] or the center of the tumor [TILsCT] or the surface of the tumor [TILsST]), and 4) location in high-power field (i.e. in tumor stroma [sTILs] or intra-tumor cells [iTILs] or total TILs [tTILs: sTILs+iTILs]). We then assessed the prognostic value of the density of TILsIM evaluated as described above. We also evaluated the correlation between the density of TILsIM and that of TILsCT/TILsST. Results: Only the densities of CD8+sTILsIM and CD8+tTILsIM evaluated in randomly selected fields were significantly associated with the survival. Furthermore, the density of CD8+TILsIM was significantly associated with that of CD8+TILsCT and CD8+TILsST. Conclusions: We concluded that best and easiest way to evaluate the density of TILs in the clinical setting may be to assess the density of CD8+tTILsIM in randomly selected fields.

    DOI: 10.18632/oncotarget.24612

    PubMed

  • Association of tumor infiltrating CD8 positive T cells and PDL-1 expression with survival after conversion surgery for unresectable gastric cancer. Reviewed

    Tanaka Hiroaki, Nishimura Junya, Miki Yuichiro, Tamura Tatsuro, Muguruma Kazuya, Shibutani Masatsune, Ohira Go, Yamazoe Sadaaki, Nagahara Hisashi, Kimura Kenjiro, Toyokawa Takahiro, Amano Ryosuke, Maeda Kiyoshi, Hirakawa Kosei, Ohira Masaichi

    JOURNAL OF CLINICAL ONCOLOGY   36 ( 4 )   2018.02( ISSN:0732-183X

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  • Association of tumor infiltrating CD8 positive T cells and PDL-1 expression with survival after conversion surgery for unresectable gastric cancer. Reviewed

    Tanaka Hiroaki, Nishimura Junya, Miki Yuichiro, Tamura Tatsuro, Muguruma Kazuya, Shibutani Masatsune, Ohira Go, Yamazoe Sadaaki, Nagahara Hisashi, Kimura Kenjiro, Toyokawa Takahiro, Amano Ryosuke, Maeda Kiyoshi, Hirakawa Kosei, Ohira Masaichi

    JOURNAL OF CLINICAL ONCOLOGY   36 ( 4 )   2018.02( ISSN:0732-183X

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  • The feasibility and short-term clinical outcomes of single-incision laparoscopic surgery for patients with complex Crohn's disease Reviewed

    Maeda Kiyoshi, Nagahara Hisashi, Shibutani Masatsune, Fukuoka Tatsunari, Nakao Shigetomi, Yamagami Hirokazu, Kamata Noriko, Muguruma Kazuya, Tanaka Hiroaki, Toyokawa Takahiro, Hirakawa Kosei, Ohira Masaichi

    SURGERY TODAY   48 ( 2 )   242 - 247   2018.02( ISSN:0941-1291

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    DOI: 10.1007/s00595-017-1581-z

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  • 複雑型クローン病患者に対する単孔式腹腔鏡下手術の実施可能性と短期臨床転帰(The feasibility and short-term clinical outcomes of single-incision laparoscopic surgery for patients with complex Crohn's disease) Reviewed

    Maeda Kiyoshi, Nagahara Hisashi, Shibutani Masatsune, Fukuoka Tatsunari, Nakao Shigetomi, Yamagami Hirokazu, Kamata Noriko, Muguruma Kazuya, Tanaka Hiroaki, Toyokawa Takahiro, Hirakawa Kosei, Ohira Masaichi

    シュプリンガー・ジャパン(株) Surgery Today   48 ( 2 )   242 - 247   2018.02( ISSN:0941-1291

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    瘻孔形成、腹腔内膿瘍形成、再発性クローン病(CD)を有する複雑型CD患者に対して単孔式腹腔鏡下手術(SILS)の安全性と実施可能性を調査し、複雑型CD患者と原発性非浸潤性CDの単純CD患者の臨床結果を比較した。2009年11月〜2016年12月に当施設でSILSを行ったCD患者50例(男性39例、女性11例、年齢中央値36歳、範囲16〜68歳)を調査した。複雑型CD25例と単純CD25例に分け、術前データと臨床転帰を解析して両群間で比較した。手術時間、失血量、開腹切開長は両群間で有意差がなかった。開腹術への変更率と追加ポートの必要性は複雑型CD群で高い傾向があった。術後合併症率と入院期間は両群間で有意差がなかった。開腹術への適切な変更や追加ポートが処理可能な腹腔鏡下手術の施行の十分な経験のある施設であれば、直腸切除、extended嚢胞切除、緊急手術の必要のない複雑型CD患者に対して、SILS技術は施行可能であることが示唆された。

  • 複雑型クローン病患者に対する単孔式腹腔鏡下手術の実施可能性と短期臨床転帰(The feasibility and short-term clinical outcomes of single-incision laparoscopic surgery for patients with complex Crohn's disease)

    Maeda Kiyoshi, Nagahara Hisashi, Shibutani Masatsune, Fukuoka Tatsunari, Nakao Shigetomi, Yamagami Hirokazu, Kamata Noriko, Muguruma Kazuya, Tanaka Hiroaki, Toyokawa Takahiro, Hirakawa Kosei, Ohira Masaichi

    Surgery Today   48 ( 2 )   242 - 247   2018.02( ISSN:0941-1291

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    瘻孔形成、腹腔内膿瘍形成、再発性クローン病(CD)を有する複雑型CD患者に対して単孔式腹腔鏡下手術(SILS)の安全性と実施可能性を調査し、複雑型CD患者と原発性非浸潤性CDの単純CD患者の臨床結果を比較した。2009年11月〜2016年12月に当施設でSILSを行ったCD患者50例(男性39例、女性11例、年齢中央値36歳、範囲16〜68歳)を調査した。複雑型CD25例と単純CD25例に分け、術前データと臨床転帰を解析して両群間で比較した。手術時間、失血量、開腹切開長は両群間で有意差がなかった。開腹術への変更率と追加ポートの必要性は複雑型CD群で高い傾向があった。術後合併症率と入院期間は両群間で有意差がなかった。開腹術への適切な変更や追加ポートが処理可能な腹腔鏡下手術の施行の十分な経験のある施設であれば、直腸切除、extended嚢胞切除、緊急手術の必要のない複雑型CD患者に対して、SILS技術は施行可能であることが示唆された。

  • The feasibility and short-term clinical outcomes of single-incision laparoscopic surgery for patients with complex Crohn’s disease Reviewed

    Kiyoshi Maeda, Hisashi Nagahara, Masatsune Shibutani, Tatsunari Fukuoka, Shigetomi Nakao, Hirokazu Yamagami, Noriko Kamata, Kazuya Muguruma, Hiroaki Tanaka, Takahiro Toyokawa, Kosei Hirakawa, Masaichi Ohira

    Surgery Today   48 ( 2 )   242 - 247   2018.02( ISSN:0941-1291

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    Publishing type:Research paper (scientific journal)  

    Purpose: Single-incision laparoscopic surgery (SILS) offers excellent cosmetic results compared with conventional multi-port laparoscopic surgery. Recently, this technique has been applied to Crohn’s disease (CD) with primary ileocolic strictures
    however, the application of a laparoscopic approach for complex CD, which involves abscess formation, fistula formation, and recurrent CD, is controversial. The aim of this study was to investigate the safety and feasibility of SILS for patients with complex disease and to compare its clinical results in patients with complex disease vs. those with simple stricture disease. Methods: Fifty patients who underwent SILS for CD were divided into two groups: those with complex disease (complex group, n = 25), and those with simple strictures (simple group, n = 25). The preoperative data and clinical outcomes were analyzed and compared between the groups. Results: The operative time, blood loss and length of laparotomy incision were not significantly different between the groups. Although the rate of conversion and need for an additional port tended to be higher in the complex group, the rate of postoperative complications and length of hospital stay did not differ significantly between the groups. Conclusion: SILS may be feasible for carefully selected patients with complex CD.

    DOI: 10.1007/s00595-017-1581-z

    PubMed

  • Comparison of the local immune status between the primary tumor and metastatic tumor in colorectal cancer Reviewed

    Shibutani Masatsune, Maeda Kiyoshi, Nagahara Hisashi, Fukuoka Tatsunari, Nakao Shigetomi, Matsutani Shiniji, Kimura Kenjiro, Toyokawa Takahiro, Amano Ryosuke, Tanaka Hiroaki, Muguruma Kazuya, Hirakawa Kosei, Ohira Masaichi

    CANCER SCIENCE   109   280 - 280   2018.01( ISSN:1349-7006

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  • Verification of the method to evaluate tumor-infiltrating lymphocytes (TILs) in colorectal cancer Reviewed

    Matsutani Shinji, Shibutani Masatsune, Maeda Kiyoshi, Nagahara Hisashi, Fukuoka Tatsunari, Nakao Shigetomi, Kimura Kenjiro, Toyokawa Takahiro, Amano Ryosuke, Tanaka Hiroaki, Muguruma Kazuya, Hirakawa Kosei, Ohira Masaichi

    CANCER SCIENCE   109   290 - 290   2018.01( ISSN:1349-7006

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  • The impact of Tumor-associated macrophage on chemoresistance via angiogenesis in colorectal cancer Reviewed

    Nakao Shigetomi, Shibutani Masatsune, Maeda Kiyoshi, Nagahara Hisashi, Fukuoka Tatsunari, Matsutani Shinji, Kimura Kenjiro, Toyokawa Takahiro, Amano Ryosuke, Tanaka Hiroaki, Muguruma Kazuya, Hirakawa Kosei, Ohira Masaichi

    CANCER SCIENCE   109   63 - 63   2018.01( ISSN:1349-7006

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  • Prognostic significance of inflammation-based and/or nutritional markers in patients with stage II gastric cancer Reviewed

    Toyokawa Takahiro, Muguruma Kazuya, Tamura Tatsuro, Shibutani Masatsune, Yamazoe Sadaaki, Kimura Kenjiro, Nagahara Hisashi, Amano Ryosuke, Yanaka Hiroaki

    CANCER SCIENCE   109   1088 - 1088   2018.01( ISSN:1349-7006

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  • Possibility of inducing tumor infiltrating lymphocytes by B cells in tertiary lymphoid structures in gastric cancer Reviewed

    Tanaka Hiroaki, Sakimura Chie, Kazuya Muguruma, Tamura Tatsuro, Shibutani Masatsune, Kimura Kenjiro, Nagahara Hisashi, Toyokawa Takahiro, Amano Ryosuke, Yashiro Masakazu, Hirakawa Kosei, Ohira Masaichi

    CANCER SCIENCE   109   837 - 837   2018.01( ISSN:1349-7006

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  • Induction of PDL-1 on neutrophils by gastric cancer cells Reviewed

    Hiramatsu Soichiro, Tanaka Hiroaki, Nishimura Jyunya, Sakimura Chie, Tamura Taturo, Shibutani Masatsune, Yamazoe Sadaaki, Toyokawa Takahiro, Amano Ryosuke D, Muguruma Kazuya, Maeda Kiyosi, Hirakawa Kousei, Ohira Masaichi

    CANCER SCIENCE   109   285 - 285   2018.01( ISSN:1349-7006

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  • Comparison of the local immune status between the primary tumor and metastatic tumor in colorectal cancer Reviewed

    Shibutani Masatsune, Maeda Kiyoshi, Nagahara Hisashi, Fukuoka Tatsunari, Nakao Shigetomi, Matsutani Shiniji, Kimura Kenjiro, Toyokawa Takahiro, Amano Ryosuke, Tanaka Hiroaki, Muguruma Kazuya, Hirakawa Kosei, Ohira Masaichi

    CANCER SCIENCE   109   280 - 280   2018.01( ISSN:1349-7006

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    Publishing type:Research paper (scientific journal)  

  • Verification of the method to evaluate tumor-infiltrating lymphocytes (TILs) in colorectal cancer Reviewed

    Matsutani Shinji, Shibutani Masatsune, Maeda Kiyoshi, Nagahara Hisashi, Fukuoka Tatsunari, Nakao Shigetomi, Kimura Kenjiro, Toyokawa Takahiro, Amano Ryosuke, Tanaka Hiroaki, Muguruma Kazuya, Hirakawa Kosei, Ohira Masaichi

    CANCER SCIENCE   109   290 - 290   2018.01( ISSN:1349-7006

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  • The impact of Tumor-associated macrophage on chemoresistance via angiogenesis in colorectal cancer Reviewed

    Nakao Shigetomi, Shibutani Masatsune, Maeda Kiyoshi, Nagahara Hisashi, Fukuoka Tatsunari, Matsutani Shinji, Kimura Kenjiro, Toyokawa Takahiro, Amano Ryosuke, Tanaka Hiroaki, Muguruma Kazuya, Hirakawa Kosei, Ohira Masaichi

    CANCER SCIENCE   109   63 - 63   2018.01( ISSN:1349-7006

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  • Prognostic significance of inflammation-based and/or nutritional markers in patients with stage II gastric cancer Reviewed

    Toyokawa Takahiro, Muguruma Kazuya, Tamura Tatsuro, Shibutani Masatsune, Yamazoe Sadaaki, Kimura Kenjiro, Nagahara Hisashi, Amano Ryosuke, Yanaka Hiroaki

    CANCER SCIENCE   109   1088 - 1088   2018.01( ISSN:1349-7006

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  • Possibility of inducing tumor infiltrating lymphocytes by B cells in tertiary lymphoid structures in gastric cancer Reviewed

    Tanaka Hiroaki, Sakimura Chie, Kazuya Muguruma, Tamura Tatsuro, Shibutani Masatsune, Kimura Kenjiro, Nagahara Hisashi, Toyokawa Takahiro, Amano Ryosuke, Yashiro Masakazu, Hirakawa Kosei, Ohira Masaichi

    CANCER SCIENCE   109   837 - 837   2018.01( ISSN:1349-7006

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  • Induction of PDL-1 on neutrophils by gastric cancer cells Reviewed

    Hiramatsu Soichiro, Tanaka Hiroaki, Nishimura Jyunya, Sakimura Chie, Tamura Taturo, Shibutani Masatsune, Yamazoe Sadaaki, Toyokawa Takahiro, Amano Ryosuke D., Muguruma Kazuya, Maeda Kiyosi, Hirakawa Kousei, Ohira Masaichi

    CANCER SCIENCE   109   285 - 285   2018.01( ISSN:1349-7006

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    Publishing type:Research paper (scientific journal)  

  • Prognostic significance of inflammation-based and/or nutritional markers in patients with stage II gastric cancer Reviewed

    Toyokawa Takahiro, Muguruma Kazuya, Tamura Tatsuro, Shibutani Masatsune, Yamazoe Sadaaki, Kimura Kenjiro, Nagahara Hisashi, Amano Ryosuke, Yanaka Hiroaki

    CANCER SCIENCE   109   1088 - 1088   2018.01( ISSN:1349-7006

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    Publishing type:Research paper (scientific journal)  

  • Possibility of inducing tumor infiltrating lymphocytes by B cells in tertiary lymphoid structures in gastric cancer Reviewed

    Tanaka Hiroaki, Sakimura Chie, Kazuya Muguruma, Tamura Tatsuro, Shibutani Masatsune, Kimura Kenjiro, Nagahara Hisashi, Toyokawa Takahiro, Amano Ryosuke, Yashiro Masakazu, Hirakawa Kosei, Ohira Masaichi

    CANCER SCIENCE   109   837 - 837   2018.01( ISSN:1349-7006

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    Publishing type:Research paper (scientific journal)  

  • Induction of PDL-1 on neutrophils by gastric cancer cells Reviewed

    Hiramatsu Soichiro, Tanaka Hiroaki, Nishimura Jyunya, Sakimura Chie, Tamura Taturo, Shibutani Masatsune, Yamazoe Sadaaki, Toyokawa Takahiro, Amano Ryosuke D, Muguruma Kazuya, Maeda Kiyosi, Hirakawa Kousei, Ohira Masaichi

    CANCER SCIENCE   109   285 - 285   2018.01( ISSN:1349-7006

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    Publishing type:Research paper (scientific journal)  

  • Comparison of the local immune status between the primary tumor and metastatic tumor in colorectal cancer Reviewed

    Shibutani Masatsune, Maeda Kiyoshi, Nagahara Hisashi, Fukuoka Tatsunari, Nakao Shigetomi, Matsutani Shiniji, Kimura Kenjiro, Toyokawa Takahiro, Amano Ryosuke, Tanaka Hiroaki, Muguruma Kazuya, Hirakawa Kosei, Ohira Masaichi

    CANCER SCIENCE   109   280 - 280   2018.01( ISSN:1349-7006

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    Publishing type:Research paper (scientific journal)  

  • The impact of Tumor-associated macrophage on chemoresistance via angiogenesis in colorectal cancer Reviewed

    Nakao Shigetomi, Shibutani Masatsune, Maeda Kiyoshi, Nagahara Hisashi, Fukuoka Tatsunari, Matsutani Shinji, Kimura Kenjiro, Toyokawa Takahiro, Amano Ryosuke, Tanaka Hiroaki, Muguruma Kazuya, Hirakawa Kosei, Ohira Masaichi

    CANCER SCIENCE   109   63 - 63   2018.01( ISSN:1349-7006

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    Publishing type:Research paper (scientific journal)  

  • Verification of the method to evaluate tumor-infiltrating lymphocytes (TILs) in colorectal cancer Reviewed

    Matsutani Shinji, Shibutani Masatsune, Maeda Kiyoshi, Nagahara Hisashi, Fukuoka Tatsunari, Nakao Shigetomi, Kimura Kenjiro, Toyokawa Takahiro, Amano Ryosuke, Tanaka Hiroaki, Muguruma Kazuya, Hirakawa Kosei, Ohira Masaichi

    CANCER SCIENCE   109   290 - 290   2018.01( ISSN:1349-7006

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  • Tumor-infiltrating lymphocytes predict the chemotherapeutic outcomes in patients with stage IV colorectal cancer Reviewed

    Masatsune Shibutani, Kiyoshi Maeda, Hisashi Nagahara, Tatsunari Fukuoka, Yasuhito Iseki, Shinji Matsutani, Shinichiro Kashiwagi, Hiroaki Tanaka, Kosei Hirakawa, Masaichi Ohira

    In Vivo   32 ( 1 )   151 - 158   2018.01( ISSN:0258-851X

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    Background/Aim: The anticancer immune response has been reported to contribute to the success of chemotherapy. The aim of this study was to evaluate the significance of the measurement of tumor-infiltrating lymphocytes (TILs) in the primary tumor using the method proposed by the International TILs Working Group as a prognostic marker of chemotherapeutic outcomes in patients with stage IV colorectal cancer (CRC). Patients and Methods: A total of 57 patients with stage IV CRC who underwent palliative chemotherapy after resection of the primary tumor were enrolled. Hematoxylin and eosin (H-E)-stained tumor sections were used for the evaluation of TILs. The density of TILs was assessed by measuring the area occupied by mononuclear inflammatory cells over the total stromal area at the invasive margin. Immunohistochemistry for CD8 was also performed, and the number of immunoreactive cytotoxic T-lymphocytes (CTLs) at the invasive margin was counted. Results: Thirty patients were classified into the high-TILs group, and 27 patients were classified into the low-TILs group. The high-TILs group had a significantly higher chemotherapeutic response rate (79.3% vs. 48.1%, p=0.025) and better progression-free survival (median survival time: 10.1 m vs. 7.3 m, p=0.0133) than the low-TILs group. Furthermore, the high-TILs group had a significantly better overall survival than the low-TILs group (median survival time: 35.5 m vs. 22.4 m, p=0.0221). The density of TILs evaluated using the H-E-stained sections showed a strong association with the number of CTLs (p&lt
    0.001). Conclusion: The measurement of TILs in the primary tumor using the method proposed by the International TILs Working Group can be used as a prognostic marker of the clinical effectiveness of palliative chemotherapy in patients with stage IV CRC.

    DOI: 10.21873/invivo.11218

    PubMed

  • Meta-analysis of Robot-assisted Versus Laparoscopic Surgery for Rectal Cancer Reviewed

    Ohtani Hiroshi, Maeda Kiyoshi, Nomura Shinya, Shinto Osamu, Mizuyama Yoko, Nakagawa Hiroji, Nagahara Hisashi, Shibutani Masatsune, Fukuoka Tatsunari, Amano Ryosuke, Hirakawa Kosei, Ohira Masaichi

    IN VIVO   32 ( 3 )   611 - 623   2018( ISSN:0258-851X

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    DOI: 10.21873/invivo.11283

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  • A Case of a Metastatic Tumor of Small Intestine Originating From an Angiosarcoma of the Head Reviewed

    Eguchi Shinpei, Maeda Kiyoshi, Nakao Shigetomi, Shibutani Masatsune, Nagahara Hisashi, Muguruma Kazuya, Toyokawa Takahiro, Hirakawa Kousei, Ohira Masaichi

    Japanese Society for Abdominal Emergency Medicine, Nihon Fukubu Kyukyu Igakkai Zasshi (Journal of Abdominal Emergency Medicine)   38 ( 7 )   1209 - 1212   2018( ISSN:1340-2242

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    <p>The patient was a 67-year-old male. He presented with abdominal distention and pain during radiotherapy for a cutaneous angiosarcoma of the head at our dermatology department. An abdominal CT scan showed thickening of the ileum wall and dilatation of the proximal small bowel extending from the thickened section. He was diagnosed as having bowel obstruction. Conservative treatment was then performed with an intestinal tube ; however, he subsequently underwent surgery because no improvement was observed. Laparoscopic observation of the abdominal cavity revealed an approximately 5-cm, dark red tumor in the ileum with dilatation of the proximal small bowel. Thus, this site was considered to be the origin of obstruction. The small bowel was partially resected through a minilaparotomy. The patient was diagnosed as having small bowel metastasis from a cutaneous angiosarcoma of the head based on the results of the histopathological tests. Small bowel metastasis from angiosarcomas is rare ; thus, we report on our case along with a review of the relevant literature.</p>

    DOI: 10.11231/jaem.38.1209

    CiNii Article

  • Two Cases of Long-Term Control of Metastatic Colorectal Cancer via FTD/TPI plus Bevacizumab in Elderly Patients Reviewed

    Shibutani Masatsune, Maeda Kiyoshi, Nagahara Hisashi, Fukuoka Tatsunari, Iseki Yasuhito, Matsutani Shinji, Wang En, Hirakawa Kosei, Ohira Masaichi

    CASE REPORTS IN ONCOLOGY   11 ( 3 )   800 - 805   2018( ISSN:1662-6575

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    DOI: 10.1159/000493849

    PubMed

  • Two Cases of the Low-Grade Appendiceal Mucinous Neoplasm (LAMN) Reviewed

    Fukui Yasuhiro, Fukuoka Tatsunari, Maeda Kiyoshi, Nagahara Hisashi, Shibutani Masatsune, Nakao Shigetomi, Matsutani Shinji, Hirakawa Kosei, Ohira Masaichi

    Japanese College of Surgeons, Nihon Gekakei Rengo Gakkaishi (Journal of Japanese College of Surgeons)   43 ( 1 )   93 - 101   2018( ISSN:0385-7883

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    <p>We report 2 cases of LAMN treated by operation. Case 1: 40 year old male. Elevated CEA level with 6.8ng/dl was pointed out and additional examinations were performed. Abdominal CT showed 85mm cystic lesion in appendix which was suspected of appendiceal mucocele. Ileocecal resection and D2 lymph node dissection was performed and pathological examination revealed LAMN. Case 2: 81 year old female. Colonoscopy showed circumferential elevated lesion at the entrance of appendix. Biopsy examination was performed and the lesion was suspected of sessile serrated adenoma/ polyp. Laparoscopic ileocecal resection with D2 lymph node dissection was performed. The pathological diagnosis was LAMN.</p><p>We underwent ileocecal resection with lymph node dissection for both cases considering potential malignancy. Generally, operative treatment is performed to LAMN because of its malignant aspect. However, thereʼs no definitive criterion of therapeutic method and operative procedure about LAMN. Therefore, further investigation and review of LAMN cases should be considered.</p>

    DOI: 10.4030/jjcs.43.93

    CiNii Article

  • Complete Response of Pulmonary Metastases from Rectal Cancer to Tegafur-Uracil/Leucovorin plus Bevacizumab in an Elderly Patient: A Case Report Reviewed

    Shibutani Masatsune, Maeda Kiyoshi, Nagahara Hisashi, Fukuoka Tatsunari, Iseki Yasuhito, Matsutani Shinji, Wang En, Hirakawa Kosei, Ohira Masaichi

    CASE REPORTS IN ONCOLOGY   11 ( 2 )   461 - 466   2018( ISSN:1662-6575

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    DOI: 10.1159/000490698

    PubMed

  • Tumor-infiltrating Lymphocytes Predict the Chemotherapeutic Outcomes in Patients with Stage IV Colorectal Cancer Reviewed

    Shibutani Masatsune, Maeda Kiyoshi, Nagahara Hisashi, Fukuoka Tatsunari, Iseki Yasuhito, Matsutani Shinji, Kashiwagi Shinichiro, Tanaka Hiroaki, Hirakawa Kosei, Ohira Masaichi

    IN VIVO   32 ( 1 )   151 - 158   2018( ISSN:0258-851X

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    DOI: 10.21873/invivo.11218

    PubMed

  • A new method for evaluating tumor-infiltrating lymphocytes (TILs) in colorectal cancer using hematoxylin and eosin (H-E)stained tumor sections Reviewed

    Yasuhito Iseki, Masatsune Shibutani, Kiyoshi Maeda, Hisashi Nagahara, Tatsunari Fukuoka, Shinji Matsutani, Shinichiro Kashiwagi, Hiroaki Tanaka, Kosei Hirakawa, Masaichi Ohira

    PLoS ONE   13 ( 4 )   e0192744   2018( ISSN:1932-6203

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    Publishing type:Research paper (scientific journal)  

    Purpose Numerous reports indicate that tumor-infiltrating lymphocytes (TILs) are a prognostic factor in various cancers and that they must be good biomarkers. However, the methods of evaluating TILs differ in each study
    thus, there is not yet a standardized methodology for evaluating TILs. The purpose of this study is to evaluate the prognostic significance of tumor-infiltrating lymphocytes (TILs) in patients with colorectal cancer (CRC) using the new method proposed by the International TILs Working Group in breast cancer and to standardize the method of evaluating TILs in CRC. Methods We retrospectively reviewed a database of 160 patients with Stage II or III CRC. The density of TILs was assessed by measuring the area occupied by mononuclear cells over the stromal area on hematoxylin and eosin (H-E)-stained sections. We set 42% as the cut-off percentage of the area occupied by TILs according to the receiver operating characteristic curve, and we classified patients into the high-TILs and the low-TILs groups. Results The rates of relapse-free survival (RFS) and overall survival (OS) in the high-TILs group were significantly higher than those in the low-TILs group. A multivariate analysis showed that the density of TILs was independently associated with RFS and OS. Moreover, the density of TILs assessed by an observer was significantly associated with the density of TILs assessed by the automated imaging software program. Conclusions The new method for evaluating TILs, which was recommended by the International TILs Working Group in breast cancer, might be a useful predictive factor in colorectal cancer patients.

    DOI: 10.1371/journal.pone.0192744

    PubMed

  • Two Cases of the Low-Grade Appendiceal Mucinous Neoplasm (LAMN)

    Fukui Yasuhiro, Fukuoka Tatsunari, Maeda Kiyoshi, Nagahara Hisashi, Shibutani Masatsune, Nakao Shigetomi, Matsutani Shinji, Hirakawa Kosei, Ohira Masaichi

    Nihon Gekakei Rengo Gakkaishi (Journal of Japanese College of Surgeons)   43 ( 1 )   93 - 101   2018( ISSN:03857883

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    <p>We report 2 cases of LAMN treated by operation. Case 1: 40 year old male. Elevated CEA level with 6.8ng/dl was pointed out and additional examinations were performed. Abdominal CT showed 85mm cystic lesion in appendix which was suspected of appendiceal mucocele. Ileocecal resection and D2 lymph node dissection was performed and pathological examination revealed LAMN. Case 2: 81 year old female. Colonoscopy showed circumferential elevated lesion at the entrance of appendix. Biopsy examination was performed and the lesion was suspected of sessile serrated adenoma/ polyp. Laparoscopic ileocecal resection with D2 lymph node dissection was performed. The pathological diagnosis was LAMN.</p><p>We underwent ileocecal resection with lymph node dissection for both cases considering potential malignancy. Generally, operative treatment is performed to LAMN because of its malignant aspect. However, thereʼs no definitive criterion of therapeutic method and operative procedure about LAMN. Therefore, further investigation and review of LAMN cases should be considered.</p>

    DOI: 10.4030/jjcs.43.93

    CiNii Article

  • [A Case of Laparoscopic Surgery Performed for Locally Advanced Rectal Cancer Suspected of Invasion to Prostate]. Reviewed

    Nagahara H, Nakao S, Fukuoka T, Shibutani M, Maeda K, Matsutani S, Doi Y, Ohtani H, Yamazaki T, Amano R, Tanaka H, Muguruma K, Yashiro M, Hirakawa K, Ohira M

    Gan to kagaku ryoho. Cancer & chemotherapy   44 ( 12 )   1523 - 1525   2017.11( ISSN:0385-0684

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  • The impact of the type of progression on survival in patients with metastatic colorectal cancer Reviewed

    Shibutani M, Maeda K, Nagahara H, Fukuoka T, Nakao S, Matsutani S, Kashiwagi S, Hirakawa K, Ohira M

    ANNALS OF ONCOLOGY   28   48 - 48   2017.11( ISSN:0923-7534

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  • The change in the psoas muscle index in neoadjuvant therapy is a predictive prognostic marker in locally advanced rectal cancer Reviewed

    Fukuoka T, Maeda K, Nagahara H, Shibutani M, Nakao S, Matsutani S, Kashiwagi S, Hirakawa K, Ohira M

    ANNALS OF ONCOLOGY   28   54 - 54   2017.11( ISSN:0923-7534

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  • The impact of the type of progression on survival in patients with metastatic colorectal cancer Reviewed

    Shibutani M., Maeda K., Nagahara H., Fukuoka T., Nakao S., Matsutani S., Kashiwagi S., Hirakawa K., Ohira M.

    ANNALS OF ONCOLOGY   28   48 - 48   2017.11( ISSN:0923-7534

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  • The change in the psoas muscle index in neoadjuvant therapy is a predictive prognostic marker in locally advanced rectal cancer Reviewed

    Fukuoka T., Maeda K., Nagahara H., Shibutani M., Nakao S., Matsutani S., Kashiwagi S., Hirakawa K., Ohira M.

    ANNALS OF ONCOLOGY   28   54 - 54   2017.11( ISSN:0923-7534

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  • [Clinical Outcome of the Patients with Anal Squamous Cell Carcinoma]. Reviewed

    Mori T, Maeda K, Fukuoka T, Shibutani M, Nagahara H, Tamura T, Ohira G, Yamazoe S, Kimura K, Toyokawa T, Amano R, Tanaka H, Muguruma K, Hirakawa K, Ohira M

    Gan to kagaku ryoho. Cancer & chemotherapy   44 ( 12 )   1647 - 1649   2017.11( ISSN:0385-0684

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  • [A Case of Small Intestinal Metastasis with Intussusception Due to Barium]. Reviewed

    Tsujio G, Nagahara H, Nakao S, Fukuoka T, Shibutani M, Maeda K, Matsutani S, Kimura K, Toyokawa T, Amano R, Tanaka H, Muguruma K, Yashiro M, Hirakawa K, Ohira M

    Gan to kagaku ryoho. Cancer & chemotherapy   44 ( 12 )   1973 - 1975   2017.11( ISSN:0385-0684

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  • [A Case of Laparoscopic Surgery Performed for Locally Advanced Rectal Cancer Suspected of Invasion to Prostate]. Reviewed

    Nagahara H, Nakao S, Fukuoka T, Shibutani M, Maeda K, Matsutani S, Doi Y, Ohtani H, Yamazaki T, Amano R, Tanaka H, Muguruma K, Yashiro M, Hirakawa K, Ohira M

    Gan to kagaku ryoho. Cancer & chemotherapy   44 ( 12 )   1523 - 1525   2017.11( ISSN:0385-0684

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    PubMed

  • [Clinical Outcome of the Patients with Anal Squamous Cell Carcinoma].

    Mori T, Maeda K, Fukuoka T, Shibutani M, Nagahara H, Tamura T, Ohira G, Yamazoe S, Kimura K, Toyokawa T, Amano R, Tanaka H, Muguruma K, Hirakawa K, Ohira M

    Gan to kagaku ryoho. Cancer & chemotherapy   44 ( 12 )   1647 - 1649   2017.11( ISSN:0385-0684

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  • [Clinical Outcome of the Patients with Anal Squamous Cell Carcinoma]. Reviewed

    Mori T, Maeda K, Fukuoka T, Shibutani M, Nagahara H, Tamura T, Ohira G, Yamazoe S, Kimura K, Toyokawa T, Amano R, Tanaka H, Muguruma K, Hirakawa K, Ohira M

    Gan to kagaku ryoho. Cancer & chemotherapy   44 ( 12 )   1647 - 1649   2017.11( ISSN:0385-0684

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    Publishing type:Research paper (scientific journal)  

    PubMed

  • [A Case of Small Intestinal Metastasis with Intussusception Due to Barium].

    Tsujio G, Nagahara H, Nakao S, Fukuoka T, Shibutani M, Maeda K, Matsutani S, Kimura K, Toyokawa T, Amano R, Tanaka H, Muguruma K, Yashiro M, Hirakawa K, Ohira M

    Gan to kagaku ryoho. Cancer & chemotherapy   44 ( 12 )   1973 - 1975   2017.11( ISSN:0385-0684

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  • [A Case of Small Intestinal Metastasis with Intussusception Due to Barium]. Reviewed

    Tsujio G, Nagahara H, Nakao S, Fukuoka T, Shibutani M, Maeda K, Matsutani S, Kimura K, Toyokawa T, Amano R, Tanaka H, Muguruma K, Yashiro M, Hirakawa K, Ohira M

    Gan to kagaku ryoho. Cancer & chemotherapy   44 ( 12 )   1973 - 1975   2017.11( ISSN:0385-0684

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  • [A Case of Laparoscopic Surgery Performed for Locally Advanced Rectal Cancer Suspected of Invasion to Prostate].

    Nagahara H, Nakao S, Fukuoka T, Shibutani M, Maeda K, Matsutani S, Doi Y, Ohtani H, Yamazaki T, Amano R, Tanaka H, Muguruma K, Yashiro M, Hirakawa K, Ohira M

    Gan to kagaku ryoho. Cancer & chemotherapy   44 ( 12 )   1523 - 1525   2017.11( ISSN:0385-0684

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  • The change in the psoas muscle index in neoadjuvant therapy is a predictive prognostic marker in locally advanced rectal cancer Reviewed

    Fukuoka T, Maeda K, Nagahara H, Shibutani M, Nakao S, Matsutani S, Kashiwagi S, Hirakawa K, Ohira M

    ANNALS OF ONCOLOGY   28   54 - 54   2017.11( ISSN:0923-7534

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  • The impact of the type of progression on survival in patients with metastatic colorectal cancer Reviewed

    Shibutani M, Maeda K, Nagahara H, Fukuoka T, Nakao S, Matsutani S, Kashiwagi S, Hirakawa K, Ohira M

    ANNALS OF ONCOLOGY   28   48 - 48   2017.11( ISSN:0923-7534

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  • The Prognostic Significance of the Tumor-infiltrating Programmed Cell Death-1(+) to CD8(+) Lymphocyte Ratio in Patients with Colorectal Cancer Reviewed

    Shibutani Masatsune, Maeda Kiyoshi, Nagahara Hisashi, Fukuoka Tatsunari, Nakao Shigetomi, Matsutani Shinji, Hirakawa Kosei, Ohira Masaichi

    ANTICANCER RESEARCH   37 ( 8 )   4165 - 4172   2017.08( ISSN:0250-7005

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    DOI: 10.21873/anticanres.11804

    PubMed

  • The Prognostic Significance of the Tumor-infiltrating Programmed Cell Death-1(+) to CD8(+) Lymphocyte Ratio in Patients with Colorectal Cancer Reviewed

    Masatsune Shibutani, Kiyoshi Maeda, Hisashi Nagahara, Tatsunari Fukuoka, Shigetomi Nakao, Shinji Matsutani, Kosei Hirakawa, Masaichi Ohira

    ANTICANCER RESEARCH   37 ( 8 )   4165 - 4172   2017.08( ISSN:0250-7005

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    Background/Aim: Tumor-infiltrating lymphocytes (TILs) have been reported to reflect the antitumor immunity of the host and correlate with the therapeutic outcomes and survival. Nowadays TILs are attracting attention as new biomarkers of diseases such as colorectal cancer. TILs are classified into several subsets, among which CD8(+) T cells directly attack cancer cells and play a central role in antitumor immunity. A high density of CD8(+) TILs has been reported to correlate with a better clinical outcome. Programmed cell death-1 (PD-1) is recognized to be a surface marker for dysfunction of T lymphocytes. However, the prognostic significance of PD-1(+) TILs remains unclear. The aim of this study was to evaluate the prognostic significance of the number of PD-1(+) TILs and the tumor-infiltrating PD-1(+) to CD8(+) lymphocyte ratio (PD-1/CD8 ratio) in patients with colorectal cancer (CRC). Patients and Methods: A total of 90 patients with stage II/III CRC who underwent curative surgery were enrolled in this study. Immunohistochemistry was used to assess the densities of PD-1(+) TILs and CD8(+) TILs. The PD-1/CD8 ratio was defined as the number of PD-1(+) TILs divided by the number of CD8(+) TILs. The optimum cut-off value for the number of PD-1(+) TILs and the PD-1/CD8 ratio was determined via a receiver operating characteristic analysis. We then assessed the prognostic significance of the number of PD-1(+) TILs and the PD-1/CD8 ratio. Results: The relapse-free and overall survival rates were significantly worse in the high-PD-1/CD8 ratio group than in the low-PD-1/CD8 ratio group (relapse-free survival: p=0.0257, overall survival: p=0.0363), although the number of PD-1(+) TILs showed no prognostic significance. Conclusion: The PD-1/CD8 ratio may, therefore, be a useful prognostic marker for stage II/III CRC. What is important for predicting the prognosis may be the PD-1/CD8 ratio rather than the absolute number of PD-1(+) TILs.

    DOI: 10.21873/anticanres.11804

    PubMed

  • A case of bowel perforation due to traumatic hernia at a pelvic fracture site: a case report and review of the literature Reviewed

    Tanaka Ryota, Nagahara Hisashi, Maeda Kiyoshi, Ohtani Hiroshi, Shibutani Masatsune, Tamura Tatsuro, Ikeya Tetsuro, Sugano Kenji, Iseki Yasuhito, Sakurai Katsunobu, Yamazoe Sadaaki, Kimura Kenjiro, Toyokawa Takahiro, Amano Ryosuke, Kubo Naoshi, Tanaka Hiroaki, Muguruma Kazuya, Hirakawa Kosei, Ohira Masaichi

    BMC SURGERY   17 ( 1 )   81   2017.07( ISSN:1471-2482

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    DOI: 10.1186/s12893-017-0278-y

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  • A case of bowel perforation due to traumatic hernia at a pelvic fracture site: a case report and review of the literature Reviewed

    Ryota Tanaka, Hisashi Nagahara, Kiyoshi Maeda, Hiroshi Ohtani, Masatsune Shibutani, Tatsuro Tamura, Tetsuro Ikeya, Kenji Sugano, Yasuhito Iseki, Katsunobu Sakurai, Sadaaki Yamazoe, Kenjiro Kimura, Takahiro Toyokawa, Ryosuke Amano, Naoshi Kubo, Hiroaki Tanaka, Kazuya Muguruma, Kosei Hirakawa, Masaichi Ohira

    BMC SURGERY   17 ( 1 )   81   2017.07( ISSN:1471-2482

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    Background: Common complications of pelvic fractures include visceral injury, large-volume hemorrhage, genitourinary injury, rectal injury, and pulmonary embolism. On the other hand, traumatic hernia is a rare complication, especially in association with pelvic fractures. We report a case of bowel perforation due to traumatic hernia at a pelvic fracture site.
    Case presentation: A 65-year-old female was presented at our hospital for further examination and treatment of ileus. She was diagnosed with bowel perforation due to traumatic hernia at a pelvic fracture site, and an emergency operation was thus immediately performed. We performed segmental jejunum resection and constructed jejunostomy, and the iliac bone fracture was fixed with four pins. In the postoperative course, she received antibiotics and vasopressors for septic shock. However, there was no need for either a ventilator, dialysis or admission to the ICU. At seven days after the operation, a residual abscess was detected in the pouch of Douglas. We performed percutaneous drainage (Clavien-Dindo IIIa) and jejunostomy closedown 35 days after the first operation. The postoperative course was without complication, but she received rehabilitation until she was able to walk unaided. She was discharged 64 days after the first operation.
    Conclusion: The occurrence of traumatic hernia is rare, especially in association with pelvic fractures. Although its rarity, traumatic hernia follows a severe course. Thus, proper diagnosis and effective treatment are necessary. Surgeons treating patients with pelvic injuries should consider the possibility of any complications and perform a work-up examination in order to achieve an accurate diagnosis at an earlier time point.

    DOI: 10.1186/s12893-017-0278-y

    PubMed

  • Significance of E-cadherin and CD44 expression in patients with unresectable metastatic colorectal cancer Reviewed

    Iseki Yasuhito, Shibutani Masatsune, Maeda Kiyoshi, Nagahara Hisashi, Ikeya Tetsuro, Hirakawa Kosei

    ONCOLOGY LETTERS   14 ( 1 )   1025 - 1034   2017.07( ISSN:1792-1074

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    DOI: 10.3892/ol.2017.6269

    PubMed

  • Significance of E-cadherin and CD44 expression in patients with unresectable metastatic colorectal cancer Reviewed

    Yasuhito Iseki, Masatsune Shibutani, Kiyoshi Maeda, Hisashi Nagahara, Tetsuro Ikeya, Kosei Hirakawa

    ONCOLOGY LETTERS   14 ( 1 )   1025 - 1034   2017.07( ISSN:1792-1074

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    The loss of adhesion molecules is reported to be associated with tumor invasion and metastasis in numerous types of cancer. Epithelial (E)-cadherin is an important molecule for cell-to-cell adhesion, while cluster of differentiation (CD)44 is an important molecule for cell-to-extracellular matrix adhesion. The focus of the present study was to evaluate the significance of the expression of E-cadherin and CD44 in patients with the unresectable metastatic colorectal cancer (CRC) who are undergoing palliative chemotherapy. Formalin-fixed, paraffin-embedded samples were obtained from 49 patients who underwent primary tumor resection and who were receiving palliative chemotherapy for unresectable metastatic CRC. The expression of E-cadherin and CD44 was evaluated using immunohistochemistry. The expression of E-cadherin was not significantly associated with progression-free survival (PFS; P=0.2825) or overall survival (OS; P=0.6617). The expression of CD44 was not associated with PFS (P=0.4365), but it did exhibit a certain level of association with OS (P=0.0699). However, the combined low expression of E-cadherin and CD44 demonstrated a significant association with decreased PFS (P=0.0101) and OS (P=0.0009). The combined loss of E-cadherin and CD44 expression also led to a reduction in the objective response rate and disease control rate (P=0.0076 and P=0.0294, respectively). A univariate analysis indicated that the combined low expression of E-cadherin and CD44 (P=0.0474) and sex (P=0.0330) were significantly associated with decreased PFS, and multivariate analysis confirmed combined low expression of E-cadherin and CD44 as an independent risk factor for decreased PFS [hazard ratio (HR), 8.276; 95% confidence interval (CI), 1.383-43.311; P=0.0227]. Univariate and multivariate analyses also indicated that the combined low expression of E-cadherin and CD44 expression was a significant prognostic factor for poor OS (HR, 15.118; 95% CI, 2.645-77.490; P=0.0039). Therefore the current study suggests that the combined low expression of E-cadherin and CD44 is an effective independent predictor of decreased chemotherapeutic outcome and survival in patients with unresectable metastatic CRC.

    DOI: 10.3892/ol.2017.6269

    PubMed

  • 特集 潰瘍性大腸炎・クローン病手術のすべて 潰瘍性大腸炎 中毒性巨大結腸症を伴う潰瘍性大腸炎に対する緊急手術

    福岡 達成, 前田 清, 渋谷 雅常, 永原 央, 中尾 重富, 大平 雅一

    手術   71 ( 7 )   965 - 969   2017.06( ISSN:00374423

  • The peripheral monocyte count is associated with the density of tumor-associated macrophages in the tumor microenvironment of colorectal cancer: a retrospective study Reviewed

    Shibutani Masatsune, Maeda Kiyoshi, Nagahara Hisashi, Fukuoka Tatsunari, Nakao Shigetomi, Matsutani Shinji, Hirakawa Kosei, Ohira Masaichi

    BMC CANCER   17 ( 1 )   404   2017.06( ISSN:1471-2407

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    DOI: 10.1186/s12885-017-3395-1

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  • The peripheral monocyte count is associated with the density of tumor-associated macrophages in the tumor microenvironment of colorectal cancer: a retrospective study Reviewed

    Masatsune Shibutani, Kiyoshi Maeda, Hisashi Nagahara, Tatsunari Fukuoka, Shigetomi Nakao, Shinji Matsutani, Kosei Hirakawa, Masaichi Ohira

    BMC CANCER   17 ( 1 )   404   2017.06( ISSN:1471-2407

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    Background: Inflammation is widely recognized to play an important role in cancer progression, and the peripheral monocyte count has been reported to correlate with the prognosis in patients with colorectal cancer. This is based on the hypothesis that the peripheral monocyte level and the density of tumor-associated macrophages (TAMs) in the cancer microenvironment correlate with each other. However, the influence of TAMs on the prognosis and the correlation between the peripheral monocyte count and the density of TAMs have not yet been elucidated.
    Methods: A total of 168 patients with stage II/III colorectal cancer were enrolled in this study. Preoperative blood samples were obtained at the time of the diagnosis before surgery. The expression of TAMs in the cancer microenvironment was assessed by immunohistochemistry.
    Results: The progression-free and overall survival rate were significantly worse in the high-TAMs group than in the low-TAMs group (p = 0.0012 and p = 0.0207, respectively). The peripheral monocyte count was significantly associated with the number of TAMs (correlation coefficients: 0.202, p = 0.047).
    Conclusions: The peripheral monocyte count was associated with the density of the TAMs, which created a microenvironment favorable for cancer development and were correlated with a poor prognosis. Therefore, the peripheral monocyte count is a useful prognostic marker reflecting the status of the tumor microenvironment.

    DOI: 10.1186/s12885-017-3395-1

    PubMed

  • The impact of the preoperative peripheral lymphocyte count and lymphocyte percentage in patients with colorectal cancer Reviewed

    Iseki Yasuhito, Shibutani Masatsune, Maeda Kiyoshi, Nagahara Hisashi, Tamura Tatsuro, Ohira Go, Yamazoe Sadaaki, Kimura Kenjiro, Toyokawa Takahiro, Amano Ryosuke, Tanaka Hiroaki, Muguruma Kazuya, Hirakawa Kosei, Ohira Masaichi

    SURGERY TODAY   47 ( 6 )   743 - 754   2017.06( ISSN:0941-1291

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    DOI: 10.1007/s00595-016-1433-2

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  • 大腸癌患者における術前末梢血リンパ球数およびリンパ球割合の影響(The impact of the preoperative peripheral lymphocyte count and lymphocyte percentage in patients with colorectal cancer) Reviewed

    Iseki Yasuhito, Shibutani Masatsune, Maeda Kiyoshi, Nagahara Hisashi, Tamura Tatsuro, Ohira Go, Yamazoe Sadaaki, Kimura Kenjiro, Toyokawa Takahiro, Amano Ryosuke, Tanaka Hiroaki, Muguruma Kazuya, Hirakawa Kosei, Ohira Masaichi

    シュプリンガー・ジャパン(株) Surgery Today   47 ( 6 )   743 - 754   2017.06( ISSN:0941-1291

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    大腸癌患者において、術前免疫能を反映する末梢血リンパ球数およびリンパ球割合が有用な生存予測因子となり得るかについて検討した。さらに、それらの生存予測因子としての正確度を比較した。ステージII/IIIの大腸癌患者362例のデータを後向きに調査し、術前末梢血リンパ球数およびリンパ球割合に基づき患者を分類した。高リンパ球数群では低リンパ球数群に比べ(カットオフ値1700/mm3)、5年無再発生存率が高い傾向を示した(p=0.0583)。また高リンパ球数群では低リンパ球数群に比べ(カットオフ値1100/mm3)、5年全生存率が有意に高かった(p=0.0021)。高リンパ球割合群では低リンパ球割合群に比べ(カットオフ値32.4%)、5年無再発生存率および5年全生存率が有意に高かった(ともにp=0.0003)。多変量解析において、リンパ球割合が全生存と独立した関連を示した(オッズ比2.168、p=0.0308)。大腸癌患者において術前末梢血リンパ球数およびリンパ球割合はともに良好な予後因子であることが示された。またリンパ球割合はリンパ球数よりも優れた生存予測因子であることが示唆された。

  • The impact of the preoperative peripheral lymphocyte count and lymphocyte percentage in patients with colorectal cancer Reviewed

    Yasuhito Iseki, Masatsune Shibutani, Kiyoshi Maeda, Hisashi Nagahara, Tatsuro Tamura, Go Ohira, Sadaaki Yamazoe, Kenjiro Kimura, Takahiro Toyokawa, Ryosuke Amano, Hiroaki Tanaka, Kazuya Muguruma, Kosei Hirakawa, Masaichi Ohira

    SURGERY TODAY   47 ( 6 )   743 - 754   2017.06( ISSN:0941-1291

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    Purpose We evaluated the prognostic significance of the peripheral lymphocyte count and lymphocyte percentage, which reflect the preoperative immune status, in patients with colorectal cancer (CRC) and then compared their accuracy as predictors of the survival.
    Methods We retrospectively reviewed a database of 362 patients. We classified the patients into high lymphocyte count and low lymphocyte count groups. We also classified the patients into high lymphocyte percentage and low lymphocyte percentage groups.
    Results The 5-year relapse-free survival (RFS) rate in the high lymphocyte count group tended to be higher than that in the low lymphocyte count group. The 5-year overall survival (OS) rate in the high lymphocyte count group was significantly higher than that in the low lymphocyte count group. In contrast, the 5-year RFS and OS rates in the high lymphocyte percentage group were both significantly higher than those in the low lymphocyte percentage group. A multivariate analysis showed that the lymphocyte percentage was independently associated with the OS.
    Conclusions These findings suggest that the lymphocyte percentage is a good predictor of the OS and may be a stronger predictor of survival than the lymphocyte count in CRC patients.

    DOI: 10.1007/s00595-016-1433-2

    PubMed

  • 大腸癌患者における術前末梢血リンパ球数およびリンパ球割合の影響(The impact of the preoperative peripheral lymphocyte count and lymphocyte percentage in patients with colorectal cancer)

    Iseki Yasuhito, Shibutani Masatsune, Maeda Kiyoshi, Nagahara Hisashi, Tamura Tatsuro, Ohira Go, Yamazoe Sadaaki, Kimura Kenjiro, Toyokawa Takahiro, Amano Ryosuke, Tanaka Hiroaki, Muguruma Kazuya, Hirakawa Kosei, Ohira Masaichi

    Surgery Today   47 ( 6 )   743 - 754   2017.06( ISSN:0941-1291

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    大腸癌患者において、術前免疫能を反映する末梢血リンパ球数およびリンパ球割合が有用な生存予測因子となり得るかについて検討した。さらに、それらの生存予測因子としての正確度を比較した。ステージII/IIIの大腸癌患者362例のデータを後向きに調査し、術前末梢血リンパ球数およびリンパ球割合に基づき患者を分類した。高リンパ球数群では低リンパ球数群に比べ(カットオフ値1700/mm3)、5年無再発生存率が高い傾向を示した(p=0.0583)。また高リンパ球数群では低リンパ球数群に比べ(カットオフ値1100/mm3)、5年全生存率が有意に高かった(p=0.0021)。高リンパ球割合群では低リンパ球割合群に比べ(カットオフ値32.4%)、5年無再発生存率および5年全生存率が有意に高かった(ともにp=0.0003)。多変量解析において、リンパ球割合が全生存と独立した関連を示した(オッズ比2.168、p=0.0308)。大腸癌患者において術前末梢血リンパ球数およびリンパ球割合はともに良好な予後因子であることが示された。またリンパ球割合はリンパ球数よりも優れた生存予測因子であることが示唆された。

  • Clinical experience of S-1 and oxaliplatin (SOX) as the first-line chemotherapy for metastatic/recurrent gastric cancer Reviewed

    Takahiro Toyokawa, Tatsuro Tamura, Masatsune Shibutani, Goh Ohira, Sadaaki Yamazoe, Kenjiro Kimura, Hisashi Nagahara, Ryosuke Amano, Hiroaki Tanaka, Kazuya Muguruma, Masakazu Yashiro, Kosei Hirakawa, Masaichi Ohira

    Japanese Journal of Cancer and Chemotherapy   44 ( 5 )   405 - 408   2017.05( ISSN:0385-0684

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    We retrospectively investigated the efficacy and safety of S-1 and oxaliplatin (SOX) as the first-line chemotherapy in patients with metastatic/recurrent gastric cancer. A total of 27 patients who received SOX as the first-line chemotherapy in our hospital were considered for the study. The SOX chemotherapy schedule consisted of 1 course every 3 weeks. S-1 was administered orally, at 80-120 mg-body, every day for 14 days. Oxaliplatin was infused at 100mg/m2 on day 1 of each course. The median number of treatment courses was 7. The response rate and disease control rate were 47.6% and 76.2%, respectively. The observed adverse events of Grade 3 or more included neutropenia (33.3%)
    peripheral neuropathy and anorexia (11.1%)
    thrombocytopenia (7.4%)
    and anemia, diarrhea, fatigue, and hypercalcemia (3.7%). The median overall survival was not achieved, and the 1-year survival rate was 63.2%. Therefore, SOX is an effective and feasible first-line chemotherapy that is easily available for ambulatory treatment of patients with metastatic/recurrent gastric cancer.

    PubMed

  • [Clinical Experience of S-1 and Oxaliplatin(SOX)as the First-Line Chemotherapy for Metastatic/Recurrent Gastric Cancer]. Reviewed

    Toyokawa T, Tamura T, Shibutani M, Ohira G, Yamazoe S, Kimura K, Nagahara H, Amano R, Tanaka H, Muguruma K, Yashiro M, Hirakawa K, Ohira M

    Gan to kagaku ryoho. Cancer & chemotherapy   44 ( 5 )   405 - 408   2017.05( ISSN:0385-0684

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  • [Clinical Experience of S-1 and Oxaliplatin(SOX)as the First-Line Chemotherapy for Metastatic/Recurrent Gastric Cancer].

    Toyokawa T, Tamura T, Shibutani M, Ohira G, Yamazoe S, Kimura K, Nagahara H, Amano R, Tanaka H, Muguruma K, Yashiro M, Hirakawa K, Ohira M

    Gan to kagaku ryoho. Cancer & chemotherapy   44 ( 5 )   405 - 408   2017.05( ISSN:0385-0684

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  • Role of systemic immune-inflammatory index, tumor infiltrating neutrophils and PD-1+T cells to predict the postoperative recurrence after S-1 adjuvant chemotherapy for gastric cancer: A retrospective study. Reviewed

    Tanaka Hiroaki, Tamura Tatsuro, Hiramatsu Soichiro, Muguruma Kazuya, Miki Yuichiro, Shibutani Masatsune, Yamazoe Sadaaki, Kimura Kenjiro, Nagahara Hisashi, Toyokawa Takahiro, Amano Ryosuke, Maeda Kiyoshi, Hirakawa Kosei, Ohira Masaichi

    JOURNAL OF CLINICAL ONCOLOGY   35 ( 4 )   2017.02( ISSN:0732-183X

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  • Role of systemic immune-inflammatory index, tumor infiltrating neutrophils and PD-1+T cells to predict the postoperative recurrence after S-1 adjuvant chemotherapy for gastric cancer: A retrospective study. Reviewed

    Tanaka Hiroaki, Tamura Tatsuro, Hiramatsu Soichiro, Muguruma Kazuya, Miki Yuichiro, Shibutani Masatsune, Yamazoe Sadaaki, Kimura Kenjiro, Nagahara Hisashi, Toyokawa Takahiro, Amano Ryosuke, Maeda Kiyoshi, Hirakawa Kosei, Ohira Masaichi

    JOURNAL OF CLINICAL ONCOLOGY   35 ( 4 )   2017.02( ISSN:0732-183X

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  • Prognostic significance of the preoperative lymphocyte-to-monocyte ratio in patients with colorectal cancer Reviewed

    Shibutani Masatsune, Maeda Kiyoshi, Nagahara Hisashi, Iseki Yasuhito, Ikeya Tetsuro, Hirakawa Kosei

    ONCOLOGY LETTERS   13 ( 2 )   1000 - 1006   2017.02( ISSN:1792-1074

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    DOI: 10.3892/ol.2016.5487

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  • Prognostic significance of the preoperative lymphocyte-to-monocyte ratio in patients with colorectal cancer Reviewed

    Masatsune Shibutani, Kiyoshi Maeda, Hisashi Nagahara, Yasuhito Iseki, Tetsuro Ikeya, Kosei Hirakawa

    ONCOLOGY LETTERS   13 ( 2 )   1000 - 1006   2017.02( ISSN:1792-1074

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    A correlation between the lymphocyte-to-monocyte ratio (LMR) and the survival of patients with hematological malignancies has been reported previously. However, there have been few studies investigating the prognostic significance of LMR in patients with solid tumors. The aim of the present study was to evaluate the prognostic significance of preoperative LMR in patients with colorectal cancer (CRC). A total of 189 patients undergoing potentially curative surgery for CRC were enrolled. The LMR was calculated from preoperative blood samples by dividing absolute lymphocyte count by absolute monocyte count. A cut-off value of 4.8 was set based on the receiver operating characteristic curve; 116 patients were classified as high-LMR, and 73 patients classified as low-LMR. The high-LMR group exhibited significantly better relapse-free survival (P=0.0018) and overall survival (P=0.0127) rates than the low-LMR group. According to the multivariate analysis of survival, preoperative LMR was identified as an independent prognostic factor for relapse-free survival (P=0.041) and overall survival (P=0.031). Therefore, preoperative LMR is a useful prognostic marker in patients with CRC.

    DOI: 10.3892/ol.2016.5487

    PubMed

  • Tumor-infiltrating lymphocytes predict the chemotherapeutic outcomes in patients with stage IV colorectal cancer Reviewed

    Shibutani M, Maeda K, Nagahara H, Fukuoka T, Iseki Y, Matsutani S, Tamura T, Ohira G, Yamazoe S, Kimura K, Toyokawa T, Amano R, Tanaka H, Muguruma K, Hirakawa K, Ohira M

    ANNALS OF ONCOLOGY   27   2016.12( ISSN:0923-7534

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  • Tumor-infiltrating lymphocytes predict the chemotherapeutic outcomes in patients with stage IV colorectal cancer Reviewed

    Shibutani M., Maeda K., Nagahara H., Fukuoka T., Iseki Y., Matsutani S., Tamura T., Ohira G., Yamazoe S., Kimura K., Toyokawa T., Amano R., Tanaka H., Muguruma K., Hirakawa K., Ohira M.

    ANNALS OF ONCOLOGY   27   2016.12( ISSN:0923-7534

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  • Tumor-infiltrating lymphocytes predict the chemotherapeutic outcomes in patients with stage IV colorectal cancer Reviewed

    Shibutani M, Maeda K, Nagahara H, Fukuoka T, Iseki Y, Matsutani S, Tamura T, Ohira G, Yamazoe S, Kimura K, Toyokawa T, Amano R, Tanaka H, Muguruma K, Hirakawa K, Ohira M

    ANNALS OF ONCOLOGY   27   2016.12( ISSN:0923-7534

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  • [A Case of Metastatic Lung Cancer from Colon Cancer with a Long Partial Response with Regorafenib Treatment]. Reviewed

    Iseki Y, Yashiro M, Shibutani M, Nagahara H, Maeda K, Matsutani S, Tamura T, Ohira G, Yamazoe S, Kimura K, Toyokawa T, Amano R, Tanaka H, Muguruma K, Hirakawa K, Ohira M

    Gan to kagaku ryoho. Cancer & chemotherapy   43 ( 12 )   2338 - 2340   2016.11( ISSN:0385-0684

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  • [A Case of Metastatic Lung Cancer from Colon Cancer with a Long Partial Response with Regorafenib Treatment]. Reviewed

    Iseki Y, Yashiro M, Shibutani M, Nagahara H, Maeda K, Matsutani S, Tamura T, Ohira G, Yamazoe S, Kimura K, Toyokawa T, Amano R, Tanaka H, Muguruma K, Hirakawa K, Ohira M

    Gan to kagaku ryoho. Cancer & chemotherapy   43 ( 12 )   2338 - 2340   2016.11( ISSN:0385-0684

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  • [A Case of Metastatic Lung Cancer from Colon Cancer with a Long Partial Response with Regorafenib Treatment].

    Iseki Y, Yashiro M, Shibutani M, Nagahara H, Maeda K, Matsutani S, Tamura T, Ohira G, Yamazoe S, Kimura K, Toyokawa T, Amano R, Tanaka H, Muguruma K, Hirakawa K, Ohira M

    Gan to kagaku ryoho. Cancer & chemotherapy   43 ( 12 )   2338 - 2340   2016.11( ISSN:0385-0684

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  • The significance of the C-reactive protein to albumin ratio as a marker for predicting survival and monitoring chemotherapeutic effectiveness in patients with unresectable metastatic colorectal cancer Reviewed

    Shibutani Masatsune, Maeda Kiyoshi, Nagahara Hisashi, Iseki Yasuhito, Hirakawa Kosei, Ohira Masaichi

    SPRINGERPLUS   5 ( 1 )   1798   2016.10( ISSN:2193-1801

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    DOI: 10.1186/s40064-016-3529-y

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  • Prognostic Significance of MicroRNA-21 Expression in Patients with Unresectable Metastatic Colon Cancer Reviewed

    Iseki Yasuhito, Shibutani Masatsune, Maeda Kiyoshi, Nagahara Hisashi, Fukuoka Tatsunari, Ikeya Tetsuro, Matsutani Shinji, Kimura Kenjiro, Toyokawa Takahiro, Amano Ryosuke, Tanaka Hiroaki, Muguruma Kazuya, Hirakawa Kosei, Ohira Masaichi

    ANTICANCER RESEARCH   36 ( 10 )   5145 - 5151   2016.10( ISSN:0250-7005

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    DOI: 10.21873/anticanres.11084

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  • Prognostic Significance of MicroRNA-21 Expression in Patients with Unresectable Metastatic Colon Cancer Reviewed

    Yasuhito Iseki, Masatsune Shibutani, Kiyoshi Maeda, Hisashi Nagahara, Tatsunari Fukuoka, Tetsuro Ikeya, Shinji Matsutani, Kenjiro Kimura, Takahiro Toyokawa, Ryosuke Amano, Hiroaki Tanaka, Kazuya Muguruma, Kosei Hirakawa, Masaichi Ohira

    ANTICANCER RESEARCH   36 ( 10 )   5145 - 5151   2016.10( ISSN:0250-7005

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    Background/Aim: MicroRNA (miR)-21 is overexpressed in most solid tumors and a high expression of miR-21 in tumor tissue is associated with a poor clinical outcome. The aim of this study was to clarify the association between the miR-21 expression in the tumor and the chemotherapeutic outcomes and survival for unresectable metastatic colon cancer (CC). Materials and Methods: Formalin-fixed, paraffin-embedded (FFPE) samples of primary tumor were obtained from 32 patients who underwent primary tumor resection and received palliative chemotherapy for unresectable metastatic CC. MiR-21 was extracted from the FFPE and the expression of miR-21 was evaluated using quantitative real time-polymerase chain reaction (RT-PCR). The expression of miR-21 was calculated with 2-Delta Delta CT. Results: A high miR-21 expression was associated with reduced progression-free survival (PFS) (p=0.0109) and tended to reduce overall survival (OS) (p=0.0675). Conclusion: miR-21 expression might be a useful prognostic marker for chemotherapeutic outcome and survival in patients with unresectable metastatic CC.

    DOI: 10.21873/anticanres.11084

    PubMed

  • The combined expression of Semaphorin4D and PlexinB1 predicts disease recurrence in colorectal cancer Reviewed

    Ikeya Tetsuro, Maeda Kiyoshi, Nagahara Hisashi, Shibutani Masatsune, Iseki Yasuhito, Hirakawa Kosei

    BMC CANCER   16   525   2016.07( ISSN:1471-2407

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    DOI: 10.1186/s12885-016-2577-6

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  • The combined expression of Semaphorin4D and PlexinB1 predicts disease recurrence in colorectal cancer Reviewed

    Tetsuro Ikeya, Kiyoshi Maeda, Hisashi Nagahara, Masatsune Shibutani, Yasuhito Iseki, Kosei Hirakawa

    BMC CANCER   16   525   2016.07( ISSN:1471-2407

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    Background: Binding to Sema4D and PlexinB1 induce angiogenesis and invasive growth in colorectal cancer (CRC). The expression of Semaphorin4D (Sema4D) and PlexinB1 has been shown to be related to the prognosis of patients with various malignancies. However, the correlation between the expression of Sema4D and PlexinB1 and the relapse-free survival in patients with colorectal cancer remains controversial.
    Methods: The study population included patients who underwent surgery for colorectal cancer (n = 226). The expression of Sema4D and PlexinB1 were analyzed by immunohistochemistry in tissue of stage I, II, and III colon cancers.
    Results: The immunohistochemical staining of colorectal cancer tissue specimens revealed that 95 (42 %) and 105 (46.4 %) of the specimens were positive for Sema4D and PlexinB1. The expression of Sema4D and PlexinB1 respectively were both found to be significantly related to stage, depth of tumor invasion, lymph node metastasis, lymphatic invasion, and venous invasion, respectively. Sixty-three patients (27.9 %) expressed both Sema4D and PlexinB1. The positive expression of both Sema4D and PlexinB1 was found to be an independent risk factor for a worse survival (HR 1.079, CI 1.013-2.868; P = 0.044).
    Conclusion: The combination of Sema4D and PlexinB1 protein detected by immunohistochemistry was therefore useful for predicting disease recurrence in CRC patients.

    DOI: 10.1186/s12885-016-2577-6

    PubMed

  • Prognostic Significance of the Preoperative Ratio of C-Reactive Protein to Albumin in Patients with Colorectal Cancer.

    Anticancer Res.   2016.05

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  • Prognostic Significance of the Preoperative Ratio of C-Reactive Protein to Albumin in Patients with Colorectal Cancer. Reviewed

    Anticancer Res.   2016.05

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  • Prognostic Significance of the Preoperative Ratio of C-Reactive Protein to Albumin in Patients with Colorectal Cancer Reviewed

    Shibutani Masatsune, Maeda Kiyoshi, Nagahara Hisashi, Iseki Yasuhito, Ikeya Tetsuro, Hirakawa Kosei

    ANTICANCER RESEARCH   36 ( 3 )   995 - 1001   2016.03( ISSN:0250-7005

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  • Prognostic Significance of the Preoperative Ratio of C-Reactive Protein to Albumin in Patients with Colorectal Cancer. Reviewed

    Shibutani M, Maeda K, Nagahara H, Iseki Y, Ikeya T, Hirakawa K

    Anticancer research   36 ( 3 )   995 - 1001   2016.03( ISSN:0250-7005

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  • Prognostic Significance of the Preoperative Ratio of C-Reactive Protein to Albumin in Patients with Colorectal Cancer.

    Shibutani M, Maeda K, Nagahara H, Iseki Y, Ikeya T, Hirakawa K

    Anticancer research   36 ( 3 )   995 - 1001   2016.03( ISSN:0250-7005

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  • Prognostic Significance of the Preoperative Ratio of C-Reactive Protein to Albumin in Patients with Colorectal Cancer Reviewed

    Masatsune Shibutani, Kiyoshi Maeda, Hisashi Nagahara, Yasuhito Iseki, Tetsuro Ikeya, Kosei Hirakawa

    ANTICANCER RESEARCH   36 ( 3 )   995 - 1001   2016.03( ISSN:0250-7005

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    Background: Inflammation has been reported to play an important role in cancer progression, and several inflammatory markers, such as the neutrophil to lymphocyte ratio (NLR) and modified Glasgow prognostic score (mGPS), have been reported to be prognostic markers. The aim of this retrospective study was to evaluate the prognostic significance of the ratio of C-reactive protein to albumin (CRP/ALB ratio) in patients with colorectal cancer who undergo potentially curative surgery. Patients and Methods: A total of 705 patients who underwent potentially curative surgery for colorectal cancer were enrolled. The CRP/ALB ratio was calculated form the preoperative samples by dividing the serum C-reactive protein level by the serum albumin level. We evaluated the correlation between the CRP/ALB ratio and survival. Furthermore, we compared the accuracy of the CRP/ALB ratio as a predictor for survival with the mGPS. Results: We set 0.0271 as the cut-off value for the CRP/ALB ratio according to a receiver operating characteristic curve analysis. Based on the cutoff value of 0.0271, 347 patients were classified into the low CRP/ALB ratio group and 358 patients were classified into the high CRP/ALB ratio group. The group with high CRP/ALB ratio had significantly worse relapse-free survival (p=0.0003) and cancer-specific survival (p=0.0026) rates than those of the low CRP/ALB ratio group. According to a multivariate analysis, the CRP/ALB ratio was identified as an independent prognostic factor for relapse-free survival (p=0.025) and cancer-specific survival (p=0.045). Moreover, even in a sub-analysis limited to patients with an mGPS of 0, the high CRP/ALB ratio group had significantly worse relapse-free survival (p=0.0015) and cancer-specific survival (p=0.0131) rates than the low CRP/ALB ratio group. Conclusion: The preoperative CRP/ALB ratio is a useful prognostic marker in patients with colorectal cancer who undergo potentially curative surgery. Moreover, the CRP/ALB ratio may be superior to the mGPS for predicting survival.

    PubMed

  • Prognostic Significance of the Preoperative Ratio of C-Reactive Protein to Albumin in Patients with Colorectal Cancer Reviewed

    Masatsune Shibutani, Kiyoshi Maeda, Hisashi Nagahara, Yasuhito Iseki, Tetsuro Ikeya, Kosei Hirakawa

    ANTICANCER RESEARCH   36 ( 3 )   995 - 1001   2016.03( ISSN:0250-7005

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    Background: Inflammation has been reported to play an important role in cancer progression, and several inflammatory markers, such as the neutrophil to lymphocyte ratio (NLR) and modified Glasgow prognostic score (mGPS), have been reported to be prognostic markers. The aim of this retrospective study was to evaluate the prognostic significance of the ratio of C-reactive protein to albumin (CRP/ALB ratio) in patients with colorectal cancer who undergo potentially curative surgery. Patients and Methods: A total of 705 patients who underwent potentially curative surgery for colorectal cancer were enrolled. The CRP/ALB ratio was calculated form the preoperative samples by dividing the serum C-reactive protein level by the serum albumin level. We evaluated the correlation between the CRP/ALB ratio and survival. Furthermore, we compared the accuracy of the CRP/ALB ratio as a predictor for survival with the mGPS. Results: We set 0.0271 as the cut-off value for the CRP/ALB ratio according to a receiver operating characteristic curve analysis. Based on the cutoff value of 0.0271, 347 patients were classified into the low CRP/ALB ratio group and 358 patients were classified into the high CRP/ALB ratio group. The group with high CRP/ALB ratio had significantly worse relapse-free survival (p=0.0003) and cancer-specific survival (p=0.0026) rates than those of the low CRP/ALB ratio group. According to a multivariate analysis, the CRP/ALB ratio was identified as an independent prognostic factor for relapse-free survival (p=0.025) and cancer-specific survival (p=0.045). Moreover, even in a sub-analysis limited to patients with an mGPS of 0, the high CRP/ALB ratio group had significantly worse relapse-free survival (p=0.0015) and cancer-specific survival (p=0.0131) rates than the low CRP/ALB ratio group. Conclusion: The preoperative CRP/ALB ratio is a useful prognostic marker in patients with colorectal cancer who undergo potentially curative surgery. Moreover, the CRP/ALB ratio may be superior to the mGPS for predicting survival.

  • A Case of Leiomyoma of the Small Intestine with Massive Bleeding Detected by Double-Balloon Endoscopy Reviewed

    Kitayama Kishu, Shibutani Masatsune, Maeda Kiyoshi, Nagahara Hisashi, Otani Hiroshi, Ohira Masaichi, Hirakawa Kosei

    Japanese Society for Abdominal Emergency Medicine, Nihon Fukubu Kyukyu Igakkai Zasshi (Journal of Abdominal Emergency Medicine)   36 ( 6 )   1081 - 1084   2016

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    <p>A 41-year-old woman visited a local doctor with the chief complaint of massive melena. Upper and lower gastrointestinal endoscopy as well as abdominal computed tomography failed to reveal the source of the bleeding. Therefore, she was transferred to our hospital for more detailed evaluation. A double-balloon endoscopy was performed under the suspicion of small intestinal hemorrhage, which revealed a minute submucosal tumor with a visible vessel was observed in the middle part of the ileum. After tattooing, laparoscopy-assisted partial resection of the small intestine was performed. Immunohistopathological analysis of the resected tissue revealed that the tumor was a leiomyoma of the small intestine. While preoperative diagnosis of the source of hemorrhage from the small intestine is thought to be difficult, some cases of successful preoperative diagnosis have been reported in recent years because of the popularization of double-balloon endoscopy and capsule endoscopy. We report a case of leiomyoma of the small intestine, that was successfully identified by double-balloon endoscopy;the tumor was subsequently resected by laparoscopic surgery.</p>

    DOI: 10.11231/jaem.36.1081

    CiNii Article

  • A Case of Goblet Cell Carcinoid with Recurrence of Peritoneal Dissemination which Was Successfully Treated by Chemotherapy Reviewed

    Ikeya Tetsuro, Shibutani Masatune, Maeda Kiyoshi, Ohtani Hiroshi, Nagahara Hisashi, Iseki Yasuhito, Hirakawa Kousei

    The Japan Society of Coloproctology, Nippon Daicho Komonbyo Gakkai Zasshi   69 ( 6 )   309 - 313   2016( ISSN:0047-1801

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    A 72-year-old man with the chief complaint of constant abdominal pain was admitted to our hospital and was later diagnosed to have ileocecal cancer. He thereafter underwent laparoscopic ileocecal resection and D3 lymphanectomy.<BR>Since the operative findings showed the presence of peritoneal dissemination around the transverse mesocolon, we resected it. The pathological findings showed the presence of goblet cell carcinoid of the appendix, pSE, int, INFc, ly1, v0, pN0, pPM0, pDM0, pRM0, P2, H0, CYX, M0. The patient was recommended to undergo adjuvant chemotherapy, but he refused. At one year after the operation, peritoneal dissemination was detected, so we began to administer chemotherapy with mFOFOX6+Bevacizumab.<BR>After 9 courses of mFOFOX6+Bevacizumab and 3 courses of LV5FU2+Bevacizumab, the dissemination was found to have remarkably decreased and no progression was observed for 12 months after the detection of recurrence. Goblet cell carcinoid is rare and its prognosis is poor. Nevertheless, there is still no established therapeutic strategy. Our findings suggest that FOFOX6+Bevacizumab combination therapy is effective for the treatment of patients demonstrating goblet cell carcinoid with a recurrence of peritoneal dissemination.

    DOI: 10.3862/jcoloproctology.69.309

    CiNii Article

  • A Case of Goblet Cell Carcinoid with Recurrence of Peritoneal Dissemination which Was Successfully Treated by Chemotherapy

    Ikeya Tetsuro, Shibutani Masatune, Maeda Kiyoshi, Ohtani Hiroshi, Nagahara Hisashi, Iseki Yasuhito, Hirakawa Kousei

    Nippon Daicho Komonbyo Gakkai Zasshi   69 ( 6 )   309 - 313   2016( ISSN:00471801

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    A 72-year-old man with the chief complaint of constant abdominal pain was admitted to our hospital and was later diagnosed to have ileocecal cancer. He thereafter underwent laparoscopic ileocecal resection and D3 lymphanectomy.<BR>Since the operative findings showed the presence of peritoneal dissemination around the transverse mesocolon, we resected it. The pathological findings showed the presence of goblet cell carcinoid of the appendix, pSE, int, INFc, ly1, v0, pN0, pPM0, pDM0, pRM0, P2, H0, CYX, M0. The patient was recommended to undergo adjuvant chemotherapy, but he refused. At one year after the operation, peritoneal dissemination was detected, so we began to administer chemotherapy with mFOFOX6+Bevacizumab.<BR>After 9 courses of mFOFOX6+Bevacizumab and 3 courses of LV5FU2+Bevacizumab, the dissemination was found to have remarkably decreased and no progression was observed for 12 months after the detection of recurrence. Goblet cell carcinoid is rare and its prognosis is poor. Nevertheless, there is still no established therapeutic strategy. Our findings suggest that FOFOX6+Bevacizumab combination therapy is effective for the treatment of patients demonstrating goblet cell carcinoid with a recurrence of peritoneal dissemination.

    DOI: 10.3862/jcoloproctology.69.309

    CiNii Article

  • The significance of the C-reactive protein to albumin ratio as a marker for predicting survival and monitoring chemotherapeutic effectiveness in patients with unresectable metastatic colorectal cancer Reviewed

    Masatsune Shibutani, Kiyoshi Maeda, Hisashi Nagahara, Yasuhito Iseki, Kosei Hirakawa, Masaichi Ohira

    SPRINGERPLUS   5 ( 1 )   1798   2016( ISSN:2193-1801

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    Inflammation has been reported to play an important role in cancer progression and various inflammatory markers have been reported to be useful prognostic markers. The aim of this retrospective study was to evaluate the significance of the C-reactive protein to albumin (CRP/ALB) ratio in colorectal cancer patients who received palliative chemotherapy. We performed a retrospective review of 99 patients who underwent palliative chemotherapy for unresectable colorectal cancer between 2005 and 2010. The cutoff value of the CRP/ALB ratio was determined based on a receiver operating characteristics curve analysis. The relationship between the CRP/ALB ratio and survival was assessed. The cutoff value for the CRP/ALB ratio was 0.183. The high pretreatment CRP/ALB ratio group showed significantly worse overall survival. Patients with a high pretreatment CRP/ALB ratio and in whom the CRP/ALB ratio normalized after chemotherapy tended to have better overall survival than those in whom both the pretreatment and posttreatment CRP/ALB ratios were high. The CRP/ALB ratio is a useful marker for predicting survival and monitoring chemotherapeutic effectiveness in patients with unresectable metastatic colorectal cancer.

    DOI: 10.1186/s40064-016-3529-y

    PubMed

  • A Case of Leiomyoma of the Small Intestine with Massive Bleeding Detected by Double-Balloon Endoscopy Reviewed

    Kitayama Kishu, Shibutani Masatsune, Maeda Kiyoshi, Nagahara Hisashi, Otani Hiroshi, Ohira Masaichi, Hirakawa Kosei

    Nihon Fukubu Kyukyu Igakkai Zasshi (Journal of Abdominal Emergency Medicine)   36 ( 6 )   1081 - 1084   2016( ISSN:13402242

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    <p>A 41-year-old woman visited a local doctor with the chief complaint of massive melena. Upper and lower gastrointestinal endoscopy as well as abdominal computed tomography failed to reveal the source of the bleeding. Therefore, she was transferred to our hospital for more detailed evaluation. A double-balloon endoscopy was performed under the suspicion of small intestinal hemorrhage, which revealed a minute submucosal tumor with a visible vessel was observed in the middle part of the ileum. After tattooing, laparoscopy-assisted partial resection of the small intestine was performed. Immunohistopathological analysis of the resected tissue revealed that the tumor was a leiomyoma of the small intestine. While preoperative diagnosis of the source of hemorrhage from the small intestine is thought to be difficult, some cases of successful preoperative diagnosis have been reported in recent years because of the popularization of double-balloon endoscopy and capsule endoscopy. We report a case of leiomyoma of the small intestine, that was successfully identified by double-balloon endoscopy;the tumor was subsequently resected by laparoscopic surgery.</p>

    DOI: 10.11231/jaem.36.1081

    CiNii Article

  • Efficacy of intracorporeal reinforcing sutures for anastomotic leakage after laparoscopic surgery for rectal cancer Reviewed

    Maeda Kiyoshi, Nagahara Hisashi, Shibutani Masatsune, Ohtani Hiroshi, Sakurai Katsunobu, Toyokawa Takahiro, Muguruma Kazuya, Tanaka Hiroaki, Amano Ryosuke, Kimura Kenjiro, Sugano Kenji, Ikeya Teturo, Iseki Yasuhito, Hirakawa Kosei

    SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES   29 ( 12 )   3535 - 3542   2015.12( ISSN:0930-2794

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    DOI: 10.1007/s00464-015-4104-2

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  • Efficacy of intracorporeal reinforcing sutures for anastomotic leakage after laparoscopic surgery for rectal cancer Reviewed

    Kiyoshi Maeda, Hisashi Nagahara, Masatsune Shibutani, Hiroshi Ohtani, Katsunobu Sakurai, Takahiro Toyokawa, Kazuya Muguruma, Hiroaki Tanaka, Ryosuke Amano, Kenjiro Kimura, Kenji Sugano, Teturo Ikeya, Yasuhito Iseki, Kosei Hirakawa

    SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES   29 ( 12 )   3535 - 42   2015.12( ISSN:0930-2794

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    The aim of the present study was to investigate the efficacy of intracorporeal reinforcing sutures for preventing anastomotic leakage (AL) after laparoscopic surgery for rectal cancer.
    This was a retrospective single-institution study consisting of 201 consecutive patients who underwent laparoscopic proctectomy with double-stapling anastomosis for primary rectal cancer between August 2007 and December 2013. The data for patients who received intracorporeal reinforcing sutures were compared with those of patients who did not receive reinforcing sutures. Patient-, tumor- and surgery-related variables were collected and examined using univariate and multivariate analyses.
    The overall incidence of AL was 9.0 % (18/201). No significant correlations were observed between the various clinicopathological factors and the use of reinforcing sutures. The multivariate analyses revealed the distance of the tumor from the anal verge, tumor size and presence of reinforcing sutures to be independent risk factors for AL. We classified the patients into two risk groups using a combination of the tumor site and tumor size: a low-risk group (patients without any risk factors, n = 134) and a high-risk group (patients with one or two risk factors, n = 67). The frequency of AL was significantly lower (p &lt; 0.02) in the patients treated with reinforcing sutures than in those treated without reinforcing sutures in the high-risk group. However, no significant differences were observed in the low-risk group.
    The use of intracorporeal reinforcing sutures may reduce the incidence of AL. A prospective randomized trial is required to evaluate the effects of reinforcing sutures in preventing AL.

    DOI: 10.1007/s00464-015-4104-2

    PubMed

  • [A Case of Demonstrating the Difficulties in Deciding How to Manage the Clinical Results after Rectal Resection]. Reviewed

    Nagashima D, Shibutani M, Maeda K, Nagahara H, Ohtani H, Sakurai K, Yamazoe S, Kimura K, Toyokawa T, Amano R, Kubo N, Tanaka H, Muguruma K, Ohira M, Hirakawa K

    Gan to kagaku ryoho. Cancer & chemotherapy   42 ( 12 )   2259 - 61   2015.11( ISSN:0385-0684

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  • クローン病患者における術前の低い予後栄養指数は腸切除後の切開部手術部位感染の発生と相関する(A preoperative low nutritional prognostic index correlates with the incidence of incisional surgical site infections after bowel resection in patients with Crohn's disease) Reviewed

    Maeda Kiyoshi, Nagahara Hisashi, Shibutani Masatsune, Otani Hiroshi, Sakurai Katsunobu, Toyokawa Takahiro, Tanaka Hiroaki, Kubo Naoshi, Muguruma Kazuya, Kamata Noriko, Yamagami Hirokazu, Hirakawa Kosei

    シュプリンガー・ジャパン(株) Surgery Today   45 ( 11 )   1366 - 1372   2015.11( ISSN:0941-1291

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    2005年1月〜2013年12月に腸切除を施行したクローン病患者177例(男性138例、女性39例、年齢16〜73歳)を対象に、各種臨床病理学的因子、術前の小野寺式栄養指数(OPNI)、手術部位感染(SSI)発生の相関を後向きに検討した。177例のうち56.5%が狭窄性疾患、残り43.5%は穿孔性疾患であった。SSIの全発生率は25.9%で、このうち切開部SSIは19.8%、臓器/体腔SSIは10.2%であった。臓器/体腔SSIの4例は吻後部漏出が原因であった。全SSIおよび切開部SSIの発生率は低OPNI患者の方が高OPNI患者よりも有意に高かった。しかし、臓器/体腔SSIの発生率とOPNIの間に有意な相関はみられなかった。多変量解析により、OPNIは切開部SSIの独立危険因子であることが示された。

  • Is Anaplastic Pancreatic Cancer Originated from Invasive Ductal Carcinoma of Pancreas? Reviewed

    Miura K., Kimura K., Amano R., Yamazoe S., Ohira G., Nishio K., Shibutani M., Sakurai K., Nagahara H., Toyokawa T., Kubo N., Tanaka H., Muguruma K., Otani H., Yashiro M., Maeda K., Ohira M., Hirakawa K.

    PANCREAS   44 ( 8 )   1398 - 1398   2015.11( ISSN:0885-3177

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  • A preoperative low nutritional prognostic index correlates with the incidence of incisional surgical site infections after bowel resection in patients with Crohn's disease Reviewed

    Maeda Kiyoshi, Nagahara Hisashi, Shibutani Masatsune, Otani Hiroshi, Sakurai Katsunobu, Toyokawa Takahiro, Tanaka Hiroaki, Kubo Naoshi, Muguruma Kazuya, Kamata Noriko, Yamagami Hirokazu, Hirakawa Kosei

    SURGERY TODAY   45 ( 11 )   1366 - 1372   2015.11( ISSN:0941-1291

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    DOI: 10.1007/s00595-014-1044-8

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  • [A Patient with Recurrent Ulcerative Colitis-Associated Rectal Cancer Attaining a Complete Response with FOLFIRI plus Bevacizumab]. Reviewed

    Iseki Y, Maeda K, Shibutani M, Nagahara H, Ikeya T, Tamura T, Ohira G, Sakurai K, Yamazoe S, Kimura K, Toyokawa T, Kubo N, Tanaka H, Muguruma K, Hirakawa K

    Gan to kagaku ryoho. Cancer & chemotherapy   42 ( 12 )   2205 - 7   2015.11( ISSN:0385-0684

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  • [A Case of Small Intestinal Metastases from Renal Cell Carcinoma with Massive Bleeding]. Reviewed

    Shibutani M, Maeda K, Nagahara H, Ohtani H, Sakurai K, Yamazoe S, Kimura K, Toyokawa T, Amano R, Kubo N, Tanaka H, Muguruma K, Ohira M, Ohsawa M, Hirakawa K

    Gan to kagaku ryoho. Cancer & chemotherapy   42 ( 12 )   2251 - 3   2015.11( ISSN:0385-0684

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  • [A Case of Demonstrating the Difficulties in Deciding How to Manage the Clinical Results after Rectal Resection]. Reviewed

    Nagashima D, Shibutani M, Maeda K, Nagahara H, Ohtani H, Sakurai K, Yamazoe S, Kimura K, Toyokawa T, Amano R, Kubo N, Tanaka H, Muguruma K, Ohira M, Hirakawa K

    Gan to kagaku ryoho. Cancer & chemotherapy   42 ( 12 )   2259 - 61   2015.11( ISSN:0385-0684

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  • Is Anaplastic Pancreatic Cancer Originated from Invasive Ductal Carcinoma of Pancreas? Reviewed

    K. Miura, K. Kimura, R. Amano, S. Yamazoe, G. Ohira, K. Nishio, M. Shibutani, K. Sakurai, H. Nagahara, T. Toyokawa, N. Kubo, H. Tanaka, K. Muguruma, H. Otani, M. Yashiro, K. Maeda, M. Ohira, K. Hirakawa

    PANCREAS   44 ( 8 )   1398 - 1398   2015.11( ISSN:0885-3177

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  • A preoperative low nutritional prognostic index correlates with the incidence of incisional surgical site infections after bowel resection in patients with Crohn's disease Reviewed

    Kiyoshi Maeda, Hisashi Nagahara, Masatsune Shibutani, Hiroshi Otani, Katsunobu Sakurai, Takahiro Toyokawa, Hiroaki Tanaka, Naoshi Kubo, Kazuya Muguruma, Noriko Kamata, Hirokazu Yamagami, Kosei Hirakawa

    SURGERY TODAY   45 ( 11 )   1366 - 72   2015.11( ISSN:0941-1291

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    The incidence of incisional surgical site infections (SSIs) is reported to be higher among patients with Crohn's disease (CD) than among those with colorectal cancer. It has also been reported that the preoperative nutritional and inflammatory status is associated with the frequency of postoperative complications. Onodera's prognostic nutritional index (OPNI) is a simple and useful parameter for determining the nutritional and inflammatory status. In the present study, we retrospectively investigated the correlation between the OPNI and the incidence of incisional SSI in patients with CD who had undergone bowel resection.
    A total of 177 CD patients who underwent abdominal surgery were enrolled. Various clinical factors and the OPNI values were evaluated to identify risk factors for incisional SSIs.
    The incidence of incisional SSIs was 19.8 %. A multivariate analysis indicated that the OPNI was an independent risk factor for incisional SSIs.
    The results of this retrospective study suggest that the OPNI is an independent risk factor for incisional SSIs in patients with a history of bowel resection for CD.

    DOI: 10.1007/s00595-014-1044-8

    PubMed

  • [A Patient with Recurrent Ulcerative Colitis-Associated Rectal Cancer Attaining a Complete Response with FOLFIRI plus Bevacizumab].

    Iseki Y, Maeda K, Shibutani M, Nagahara H, Ikeya T, Tamura T, Ohira G, Sakurai K, Yamazoe S, Kimura K, Toyokawa T, Kubo N, Tanaka H, Muguruma K, Hirakawa K

    Gan to kagaku ryoho. Cancer & chemotherapy   42 ( 12 )   2205 - 7   2015.11( ISSN:0385-0684

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  • [A Patient with Recurrent Ulcerative Colitis-Associated Rectal Cancer Attaining a Complete Response with FOLFIRI plus Bevacizumab]. Reviewed

    Iseki Y, Maeda K, Shibutani M, Nagahara H, Ikeya T, Tamura T, Ohira G, Sakurai K, Yamazoe S, Kimura K, Toyokawa T, Kubo N, Tanaka H, Muguruma K, Hirakawa K

    Gan to kagaku ryoho. Cancer & chemotherapy   42 ( 12 )   2205 - 7   2015.11( ISSN:0385-0684

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  • [A Case of Small Intestinal Metastases from Renal Cell Carcinoma with Massive Bleeding].

    Shibutani M, Maeda K, Nagahara H, Ohtani H, Sakurai K, Yamazoe S, Kimura K, Toyokawa T, Amano R, Kubo N, Tanaka H, Muguruma K, Ohira M, Ohsawa M, Hirakawa K

    Gan to kagaku ryoho. Cancer & chemotherapy   42 ( 12 )   2251 - 3   2015.11( ISSN:0385-0684

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  • [A Case of Small Intestinal Metastases from Renal Cell Carcinoma with Massive Bleeding]. Reviewed

    Shibutani M, Maeda K, Nagahara H, Ohtani H, Sakurai K, Yamazoe S, Kimura K, Toyokawa T, Amano R, Kubo N, Tanaka H, Muguruma K, Ohira M, Ohsawa M, Hirakawa K

    Gan to kagaku ryoho. Cancer & chemotherapy   42 ( 12 )   2251 - 3   2015.11( ISSN:0385-0684

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  • [A Case of Demonstrating the Difficulties in Deciding How to Manage the Clinical Results after Rectal Resection].

    Nagashima D, Shibutani M, Maeda K, Nagahara H, Ohtani H, Sakurai K, Yamazoe S, Kimura K, Toyokawa T, Amano R, Kubo N, Tanaka H, Muguruma K, Ohira M, Hirakawa K

    Gan to kagaku ryoho. Cancer & chemotherapy   42 ( 12 )   2259 - 61   2015.11( ISSN:0385-0684

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  • クローン病患者における術前の低い予後栄養指数は腸切除後の切開部手術部位感染の発生と相関する(A preoperative low nutritional prognostic index correlates with the incidence of incisional surgical site infections after bowel resection in patients with Crohn's disease)

    Maeda Kiyoshi, Nagahara Hisashi, Shibutani Masatsune, Otani Hiroshi, Sakurai Katsunobu, Toyokawa Takahiro, Tanaka Hiroaki, Kubo Naoshi, Muguruma Kazuya, Kamata Noriko, Yamagami Hirokazu, Hirakawa Kosei

    Surgery Today   45 ( 11 )   1366 - 1372   2015.11( ISSN:0941-1291

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    2005年1月〜2013年12月に腸切除を施行したクローン病患者177例(男性138例、女性39例、年齢16〜73歳)を対象に、各種臨床病理学的因子、術前の小野寺式栄養指数(OPNI)、手術部位感染(SSI)発生の相関を後向きに検討した。177例のうち56.5%が狭窄性疾患、残り43.5%は穿孔性疾患であった。SSIの全発生率は25.9%で、このうち切開部SSIは19.8%、臓器/体腔SSIは10.2%であった。臓器/体腔SSIの4例は吻後部漏出が原因であった。全SSIおよび切開部SSIの発生率は低OPNI患者の方が高OPNI患者よりも有意に高かった。しかし、臓器/体腔SSIの発生率とOPNIの間に有意な相関はみられなかった。多変量解析により、OPNIは切開部SSIの独立危険因子であることが示された。

  • Programmed Death-1 Ligand-1 (PDL1) Expression Is Associated with the Prognosis of Patients with Stage II/III Gastric Cancer Reviewed

    Tamura Tatsuro, Ohira Masaichi, Tanaka Hiroaki, Muguruma Kazuya, Toyokawa Takahiro, Kubo Naoshi, Sakurai Katsunobu, Amano Ryosuke, Kimura Kenjiro, Shibutani Masatsune, Maeda Kiyoshi, Hirakawa Kosei

    ANTICANCER RESEARCH   35 ( 10 )   5369 - 5376   2015.10( ISSN:0250-7005

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  • Programmed Death-1 Ligand-1 (PDL1) Expression Is Associated with the Prognosis of Patients with Stage II/III Gastric Cancer. Reviewed

    Tamura T, Ohira M, Tanaka H, Muguruma K, Toyokawa T, Kubo N, Sakurai K, Amano R, Kimura K, Shibutani M, Maeda K, Hirakawa K

    Anticancer research   35 ( 10 )   5369 - 76   2015.10( ISSN:0250-7005

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  • Programmed Death-1 Ligand-1 (PDL1) Expression Is Associated with the Prognosis of Patients with Stage II/III Gastric Cancer Reviewed

    Tatsuro Tamura, Masaichi Ohira, Hiroaki Tanaka, Kazuya Muguruma, Takahiro Toyokawa, Naoshi Kubo, Katsunobu Sakurai, Ryosuke Amano, Kenjiro Kimura, Masatsune Shibutani, Kiyoshi Maeda, Kosei Hirakawa

    ANTICANCER RESEARCH   35 ( 10 )   5369 - 5376   2015.10( ISSN:0250-7005

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    Background/Aim: The cell surface receptor programmed death-1 (PD1) and its ligand (PDL1) have been detected in various cancer types. It has been reported that expression of PDL1 and PD1 in a tumor is associated with poor prognosis of the patient. In the present study, we retrospectively examined tumor expression of PDL1 and intratumoral PD1(+) cell infiltration, and assessed their relationship with patient prognosis according to the pathological stage of gastric cancer. Materials and Methods: PDL1 and PD1 expression in primary tumors from 431 patients was evaluated using immuno histochemistry. The association between the expression of PDL1/PD1 and clinicopathological features was assessed. Results: High expression of PDL1 was observed in 128 (29.6%) patients. PDL1 expression was correlated with tumor infiltration of PD1(+) cells. In multivariate analysis, PDL1 expression was associated with worse overall survival. In subset analysis, PDL1 expression was significantly associated with survival in patients with stage II/III gastric cancer. In conclusion, PDL1 was an independent prognostic factor for patients with stage II/III gastric cancer. Our results suggested that patients with stage II/III gastric cancer might be appropriate for PD1/PDL1targeted therapy.

  • Programmed Death-1 Ligand-1 (PDL1) Expression Is Associated with the Prognosis of Patients with Stage II/III Gastric Cancer.

    Tamura T, Ohira M, Tanaka H, Muguruma K, Toyokawa T, Kubo N, Sakurai K, Amano R, Kimura K, Shibutani M, Maeda K, Hirakawa K

    Anticancer research   35 ( 10 )   5369 - 76   2015.10( ISSN:0250-7005

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  • Programmed Death-1 Ligand-1 (PDL1) Expression Is Associated with the Prognosis of Patients with Stage II/III Gastric Cancer. Reviewed

    Tamura T, Ohira M, Tanaka H, Muguruma K, Toyokawa T, Kubo N, Sakurai K, Amano R, Kimura K, Shibutani M, Maeda K, Hirakawa K

    Anticancer research   35 ( 10 )   5369 - 76   2015.10( ISSN:0250-7005

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  • Prognostic significance of the lymphocyte-to-monocyte ratio in patients with metastatic colorectal cancer Reviewed

    Shibutani Masatsune, Maeda Kiyoshi, Nagahara Hisashi, Ohtani Hiroshi, Sakurai Katsunobu, Yamazoe Sadaaki, Kimura Kenjiro, Toyokawa Takahiro, Amano Ryosuke, Tanaka Hiroaki, Muguruma Kazuya, Hirakawa Kosei

    WORLD JOURNAL OF GASTROENTEROLOGY   21 ( 34 )   9966 - 9973   2015.09( ISSN:1007-9327

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    DOI: 10.3748/wjg.v21.i34.9966

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  • Prognostic significance of the lymphocyte-to-monocyte ratio in patients with metastatic colorectal cancer.

    Shibutani M, Maeda K, Nagahara H, Ohtani H, Sakurai K, Yamazoe S, Kimura K, Toyokawa T, Amano R, Tanaka H, Muguruma K, Hirakawa K

    World journal of gastroenterology   21 ( 34 )   9966 - 73   2015.09( ISSN:1007-9327

  • Prognostic significance of the lymphocyte-to-monocyte ratio in patients with metastatic colorectal cancer.

    World J gastroenterology   2015.09

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  • Significance of Markers of Systemic Inflammation for Predicting Survival and Chemotherapeutic Outcomes and Monitoring Tumor Progression in Patients with Unresectable Metastatic Colorectal Cancer. Reviewed

    Anticancer Res.   2015.09

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    Publishing type:Research paper (scientific journal)   Kind of work:Single Work  

  • Significance of Markers of Systemic Inflammation for Predicting Survival and Chemotherapeutic Outcomes and Monitoring Tumor Progression in Patients with Unresectable Metastatic Colorectal Cancer. Reviewed

    Shibutani M, Maeda K, Nagahara H, Ohtani H, Sakurai K, Yamazoe A, Kimura K, Toyokawa T, Amano R, Kubo N, Tanaka H, Muguruma K, Ohira M, Hirakawa K

    Anticancer research   35 ( 9 )   5037 - 46   2015.09( ISSN:0250-7005

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  • Significance of Markers of Systemic Inflammation for Predicting Survival and Chemotherapeutic Outcomes and Monitoring Tumor Progression in Patients with Unresectable Metastatic Colorectal Cancer Reviewed

    Shibutani Masatsune, Maeda Kiyoshi, Nagahara Hisashi, Ohtani Hiroshi, Sakurai Katsunobu, Yamazoe Sadaaki, Kimura Kenjiro, Toyokawa Takahiro, Amano Ryosuke, Kubo Naoshi, Tanaka Hiroaki, Muguruma Kazuya, Ohira Masaichi, Hirakawa Kosei

    ANTICANCER RESEARCH   35 ( 9 )   5037 - 5046   2015.09( ISSN:0250-7005

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  • Significance of Markers of Systemic Inflammation for Predicting Survival and Chemotherapeutic Outcomes and Monitoring Tumor Progression in Patients with Unresectable Metastatic Colorectal Cancer.

    Anticancer Res.   2015.09

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  • Prognostic significance of the lymphocyte-to-monocyte ratio in patients with metastatic colorectal cancer Reviewed

    Masatsune Shibutani, Kiyoshi Maeda, Hisashi Nagahara, Hiroshi Ohtani, Katsunobu Sakurai, Sadaaki Yamazoe, Kenjiro Kimura, Takahiro Toyokawa, Ryosuke Amano, Hiroaki Tanaka, Kazuya Muguruma, Kosei Hirakawa

    WORLD JOURNAL OF GASTROENTEROLOGY   21 ( 34 )   9966 - 9973   2015.09( ISSN:1007-9327

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    AIM: To evaluate the prognostic significance of the lymphocyte to monocyte ratio (LMR) in patients with unresectable metastatic colorectal cancer who received palliative chemotherapy.
    METHODS: A total of 104 patients with unresectable metastatic colorectal cancer who underwent palliative chemotherapy were enrolled. The LMR was calculated from blood samples by dividing the absolute lymphocyte count by the absolute monocyte count. Pretreatment LMR values were measured within one week before the initiation of chemotherapy, while post-treatment LMR values were measured eight weeks after the initiation of chemotherapy.
    RESULTS: The median pre-treatment LMR was 4.16 (range: 0.58-14.06). We set 3.38 as the cut-off level based on the receiver operating characteristic curve. Based on the cut-off level of 3.38, 66 patients were classified into the high pre-treatment LMR group and 38 patients were classified into the low pretreatment LMR group. The low pre-treatment LMR group had a significantly worse overall survival rate (P = 0.0011). Moreover, patients who demonstrated low pre-treatment LMR and normalization after treatment exhibited a better overall survival rate than the patients with low pre-treatment and post-treatment LMR values.
    CONCLUSION: The lymphocyte to monocyte ratio is a useful prognostic marker in patients with unresectable metastatic colorectal cancer who receive palliative chemotherapy.

    DOI: 10.3748/wjg.v21.i34.9966

    PubMed

  • Prognostic significance of the lymphocyte-to-monocyte ratio in patients with metastatic colorectal cancer

    Masatsune Shibutani, Kiyoshi Maeda, Hisashi Nagahara, Hiroshi Ohtani, Katsunobu Sakurai, Sadaaki Yamazoe, Kenjiro Kimura, Takahiro Toyokawa, Ryosuke Amano, Hiroaki Tanaka, Kazuya Muguruma, Kosei Hirakawa

    WORLD JOURNAL OF GASTROENTEROLOGY   21 ( 34 )   9966 - 9973   2015.09( ISSN:1007-9327

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    AIM: To evaluate the prognostic significance of the lymphocyte to monocyte ratio (LMR) in patients with unresectable metastatic colorectal cancer who received palliative chemotherapy.
    METHODS: A total of 104 patients with unresectable metastatic colorectal cancer who underwent palliative chemotherapy were enrolled. The LMR was calculated from blood samples by dividing the absolute lymphocyte count by the absolute monocyte count. Pretreatment LMR values were measured within one week before the initiation of chemotherapy, while post-treatment LMR values were measured eight weeks after the initiation of chemotherapy.
    RESULTS: The median pre-treatment LMR was 4.16 (range: 0.58-14.06). We set 3.38 as the cut-off level based on the receiver operating characteristic curve. Based on the cut-off level of 3.38, 66 patients were classified into the high pre-treatment LMR group and 38 patients were classified into the low pretreatment LMR group. The low pre-treatment LMR group had a significantly worse overall survival rate (P = 0.0011). Moreover, patients who demonstrated low pre-treatment LMR and normalization after treatment exhibited a better overall survival rate than the patients with low pre-treatment and post-treatment LMR values.
    CONCLUSION: The lymphocyte to monocyte ratio is a useful prognostic marker in patients with unresectable metastatic colorectal cancer who receive palliative chemotherapy.

    DOI: 10.3748/wjg.v21.i34.9966

  • Significance of Markers of Systemic Inflammation for Predicting Survival and Chemotherapeutic Outcomes and Monitoring Tumor Progression in Patients with Unresectable Metastatic Colorectal Cancer Reviewed

    Masatsune Shibutani, Kiyoshi Maeda, Hisashi Nagahara, Hiroshi Ohtani, Katsunobu Sakurai, Sadaaki Yamazoe, Kenjiro Kimura, Takahiro Toyokawa, Ryosuke Amano, Naoshi Kubo, Hiroaki Tanaka, Kazuya Muguruma, Masaichi Ohira, Kosei Hirakawa

    ANTICANCER RESEARCH   35 ( 9 )   5037 - 5046   2015.09( ISSN:0250-7005

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    Background: Markers of systemic inflammation, such as the neutrophil to lymphocyte ratio (NLR), C-reactive protein (CRP) level and Glasgow prognostic score (GPS), have been reported to be useful prognostic indicators for various types of cancers. However, most of the existing reports investigated the preoperative status, and the significance of markers of systemic inflammation remains unclear in patients with unresectable metastatic colorectal cancer. The aim of the present retrospective study was to evaluate the significance of markers of systemic inflammation for predicting the prognosis and chemotherapeutic outcomes and monitoring the progression of the tumor in patients with unresectable metastatic colorectal cancer receiving palliative chemotherapy. Patients and Methods: A total of 110 patients with unresectable metastatic colorectal cancer who underwent palliative chemotherapy for metastatic tumors were enrolled in the study. We evaluated the relationships between the survival/chemotherapeutic response and pre-/post-treatment markers of systemic inflammation. The pre-treatment markers of systemic inflammation were measured within one week before the initiation of chemotherapy and the post-treatment markers of systemic inflammation were measured eight weeks after initiation of chemotherapy. Results: The overall survival rates were significantly worse in the group with high pre-treatment NLR/CRP/GPS, and that with high post-treatment CRP/GPS; the progression-free survival rate was significantly worse in the high post-treatment CRP group. As for chemotherapeutic response, patients with a low post-treatment CRP level had a significantly higher disease control rate than those with a high post-treatment CRP level. Moreover, the patients with a high pre-treatment CRP level and normalization after treatment exhibited better overall and progression-free survival rates and had a significantly higher disease control rate than those with high pre-and posttreatment CRP levels. Conclusion: Pre-treatment markers of systemic inflammation are useful for predicting prognosis in patients with unresectable metastatic colorectal cancer who receive palliative chemotherapy. Moreover, the CRP level can be used as a marker for predicting chemotherapeutic outcome and monitoring the progression of the tumor.

  • Significance of Markers of Systemic Inflammation for Predicting Survival and Chemotherapeutic Outcomes and Monitoring Tumor Progression in Patients with Unresectable Metastatic Colorectal Cancer.

    Shibutani M, Maeda K, Nagahara H, Ohtani H, Sakurai K, Yamazoe A, Kimura K, Toyokawa T, Amano R, Kubo N, Tanaka H, Muguruma K, Ohira M, Hirakawa K

    Anticancer research   35 ( 9 )   5037 - 46   2015.09( ISSN:0250-7005

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  • Significance of Markers of Systemic Inflammation for Predicting Survival and Chemotherapeutic Outcomes and Monitoring Tumor Progression in Patients with Unresectable Metastatic Colorectal Cancer. Reviewed

    Shibutani M, Maeda K, Nagahara H, Ohtani H, Sakurai K, Yamazoe A, Kimura K, Toyokawa T, Amano R, Kubo N, Tanaka H, Muguruma K, Ohira M, Hirakawa K

    Anticancer research   35 ( 9 )   5037 - 46   2015.09( ISSN:0250-7005

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  • Significance of Markers of Systemic Inflammation for Predicting Survival and Chemotherapeutic Outcomes and Monitoring Tumor Progression in Patients with Unresectable Metastatic Colorectal Cancer.

    Anticancer Res.   2015.09

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  • Inflammation-based factors and prognosis in patients with colorectal cancer Reviewed

    Maeda Kiyoshi, Shibutani Masatusne, Otani Hiroshi, Nagahara Hisashi, Ikeya Tetsuro, Iseki Yasuhito, Tanaka Hiroaki, Muguruma Kazuya, Hirakawa Kosei

    WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY   7 ( 8 )   111 - 117   2015.08( ISSN:1948-5204

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    DOI: 10.4251/wjgo.v7.i8.111

  • Epithelial mesenchymal transition may contribute to anaplastic change of pancreatic ductal adenocarcinoma Reviewed

    Miura Kotaro, Kimura Kenjiro, Amano Ryosuke, Yamazoe Sadaaki, Ohira Go, Nishio Kohei, Shibutani Masatsune, Sakurai Katsunobu, Nagahara Hisashi, Toyokawa Takahiro, Kubo Naoshi, Tanaka Hiroaki, Muguruma Kazuya, Otani Hiroshi, Yashiro Masakazu, Maeda Kiyoshi, Ohira Masaichi, Hirakawa Kosei

    CANCER RESEARCH   75   2015.08( ISSN:0008-5472

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    DOI: 10.1158/1538-7445.AM2015-5276

  • The albumin to globulin ratio predicts chemotherapeutic outcomes in patients with unresectable metastatic CRC Reviewed

    Shibutani Masatsune, Maeda Kiyoshi, Nagahara Hisashi, Ohtani Hiroshi, Iseki Yasuhito, Ikeya Tetsuro, Sugano Kenji, Sakurai Katsunobu, Yamazoe Sadaaki, Kimura Kenjiro, Toyokawa Takahiro, Amano Ryosuke, Kubo Naoshi, Tanaka Hiroaki, Muguruma Kazuya, Ohira Masaichi, Hirakawa Kosei

    CANCER RESEARCH   75   2015.08( ISSN:0008-5472

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    DOI: 10.1158/1538-7445.AM2015-577

  • Impact of the preoperative Controlling Nutritional Status (CONUT) score on the clinical outcome after curative surgery for colorectal cancer Reviewed

    Iseki Yasuhito, Shibutani Masatsune, Maeda Kiyoshi, Nagahara Hisashi, Ohtani Hiroshi, Ikeya Tetsuro, Sugano Kenji, Yamazoe Sadaaki, Sakurai Katsinobu, Kimura Kenjiro, Toyokawa Takahiro, Amano Ryosuke, Kubo Naoshi, Tanaka Hiroaki, Muguruma Kazuya, Ohira Masaichi, Hirakawa Kosei

    CANCER RESEARCH   75   2015.08( ISSN:0008-5472

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    DOI: 10.1158/1538-7445.AM2015-3418

  • Epithelial mesenchymal transition may contribute to anaplastic change of pancreatic ductal adenocarcinoma Reviewed

    Kotaro Miura, Kenjiro Kimura, Ryosuke Amano, Sadaaki Yamazoe, Go Ohira, Kohei Nishio, Masatsune Shibutani, Katsunobu Sakurai, Hisashi Nagahara, Takahiro Toyokawa, Naoshi Kubo, Hiroaki Tanaka, Kazuya Muguruma, Hiroshi Otani, Masakazu Yashiro, Kiyoshi Maeda, Masaichi Ohira, Kosei Hirakawa

    CANCER RESEARCH   75   2015.08( ISSN:0008-5472

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    DOI: 10.1158/1538-7445.AM2015-5276

  • Inflammation-based factors and prognosis in patients with colorectal cancer Reviewed

    Kiyoshi Maeda, Masatusne Shibutani, Hiroshi Otani, Hisashi Nagahara, Tetsuro Ikeya, Yasuhito Iseki, Hiroaki Tanaka, Kazuya Muguruma, Kosei Hirakawa

    WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY   7 ( 8 )   111 - 117   2015.08( ISSN:1948-5204

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    Several parameters for predicting survival in patients with colorectal cancer have been identified, including the performance status, age, gender and tumor-node-metastasis (TNM) stage. Although the TNM stage is important and useful for predicting the prognosis and determining the appropriate treatment, it is well known that the survival time varies widely, even in patients with the same stage of disease. Therefore, the identification of new parameters capable of more precisely predicting patient survival is needed to help select the optimal treatment, especially in patients in the advanced stage of disease. Although the TNM stage reflects the tumor characteristics, cancer progression and survival are not determined solely based on the local characteristics of the tumor, but also the host systemic immune/inflammatory response. Therefore, using a combination of parameters that reflect both tumor characteristics and the host systemic inflammatory status is thought to be important for accurately predicting patient survival.

    DOI: 10.4251/wjgo.v7.i8.111

  • Impact of the preoperative Controlling Nutritional Status (CONUT) score on the clinical outcome after curative surgery for colorectal cancer Reviewed

    Yasuhito Iseki, Masatsune Shibutani, Kiyoshi Maeda, Hisashi Nagahara, Hiroshi Ohtani, Tetsuro Ikeya, Kenji Sugano, Sadaaki Yamazoe, Katsinobu Sakurai, Kenjiro Kimura, Takahiro Toyokawa, Ryosuke Amano, Naoshi Kubo, Hiroaki Tanaka, Kazuya Muguruma, Masaichi Ohira, Kosei Hirakawa

    CANCER RESEARCH   75   2015.08( ISSN:0008-5472

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    DOI: 10.1158/1538-7445.AM2015-3418

  • The albumin to globulin ratio predicts chemotherapeutic outcomes in patients with unresectable metastatic CRC Reviewed

    Masatsune Shibutani, Kiyoshi Maeda, Hisashi Nagahara, Hiroshi Ohtani, Yasuhito Iseki, Tetsuro Ikeya, Kenji Sugano, Katsunobu Sakurai, Sadaaki Yamazoe, Kenjiro Kimura, Takahiro Toyokawa, Ryosuke Amano, Naoshi Kubo, Hiroaki Tanaka, Kazuya Muguruma, Masaichi Ohira, Kosei Hirakawa

    CANCER RESEARCH   75   2015.08( ISSN:0008-5472

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    DOI: 10.1158/1538-7445.AM2015-577

  • The prognostic significance of the postoperative prognostic nutritional index in patients with colorectal cancer Reviewed

    Shibutani Masatsune, Maeda Kiyoshi, Nagahara Hisashi, Ohtani Hiroshi, Iseki Yasuhito, Ikeya Tetsuro, Sugano Kenji, Hirakawa Kosei

    BMC CANCER   15   521   2015.07( ISSN:1471-2407

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    DOI: 10.1186/s12885-015-1537-x

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  • The prognostic significance of the postoperative prognostic nutritional index in patients with colorectal cancer.

    Shibutani M, Maeda K, Nagahara H, Ohtani H, Iseki Y, Ikeya T, Sugano K, Hirakawa K

    BMC cancer   15   521   2015.07

  • Impact of the Preoperative Controlling Nutritional Status (CONUT) Score on the Survival after Curative Surgery for Colorectal Cancer Reviewed

    Iseki Yasuhito, Shibutani Masatsune, Maeda Kiyoshi, Nagahara Hisashi, Ohtani Hiroshi, Sugano Kenji, Ikeya Tetsuro, Muguruma Kazuya, Tanaka Hiroaki, Toyokawa Takahiro, Sakurai Katsunobu, Hirakawa Kosei

    PLOS ONE   10 ( 7 )   e0132488   2015.07( ISSN:1932-6203

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    DOI: 10.1371/journal.pone.0132488

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  • The prognostic significance of the postoperative prognostic nutritional index in patients with colorectal cancer.

    BMC cancer   2015.07

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  • The prognostic significance of the postoperative prognostic nutritional index in patients with colorectal cancer Reviewed

    Masatsune Shibutani, Kiyoshi Maeda, Hisashi Nagahara, Hiroshi Ohtani, Yasuhito Iseki, Tetsuro Ikeya, Kenji Sugano, Kosei Hirakawa

    BMC CANCER   15   521   2015.07( ISSN:1471-2407

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    Background: The preoperative prognostic nutritional index (PNI) has been reported to correlate with the prognosis in patents with various carcinomas. However, the prognostic significance of the postoperative PNI is unknown. The aim of this study was to evaluate the prognostic significance of the postoperative PNI in patients with colorectal cancer (CRC).
    Methods: Two hundred and eighteen patients who underwent potentially curative surgery for stage II/III CRC were enrolled in this study. The PNI was calculated as 10 x serum albumin concentration (g/dl) + 0.005 x lymphocyte count (/mm(3)). The preoperative PNI was measured within two weeks before the operation and the postoperative PNI were measured at the first visit after leaving the hospital. We then examined the correlations between the preoperative/postoperative PNI and the prognosis for survival.
    Results: In the validation study, the median preoperative PNI was 47.90 (range: 32.45-61.36) and the median postoperative PNI was 48.69 (range: 32.62-66.96). According to the receiver operating characteristic (ROC) curve, we set 43.0 as the cut-off value in the validation study. For both the preoperative and postoperative PNI, the overall survival rates were significantly worse in the low PNI group in the validation study (preoperative PNI, rho = 0.0374; postoperative PNI, rho = 0.0005). In the multivariate analysis of the validation study, the combination of pre- and postoperative PNI was an independent predictor of poor overall survival (rho = 0.006).
    Conclusions: The postoperative PNI is, in addition to the preoperative PNI, a useful prognostic marker. The combination of pre- and postoperative PNI was an independent prognostic factor in patients with CRC who underwent potentially curative surgery and is important for considering the long-term outcome in patients with CRC.

    DOI: 10.1186/s12885-015-1537-x

    PubMed

  • The prognostic significance of the postoperative prognostic nutritional index in patients with colorectal cancer

    Masatsune Shibutani, Kiyoshi Maeda, Hisashi Nagahara, Hiroshi Ohtani, Yasuhito Iseki, Tetsuro Ikeya, Kenji Sugano, Kosei Hirakawa

    BMC CANCER   15   2015.07( ISSN:1471-2407

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    Background: The preoperative prognostic nutritional index (PNI) has been reported to correlate with the prognosis in patents with various carcinomas. However, the prognostic significance of the postoperative PNI is unknown. The aim of this study was to evaluate the prognostic significance of the postoperative PNI in patients with colorectal cancer (CRC).
    Methods: Two hundred and eighteen patients who underwent potentially curative surgery for stage II/III CRC were enrolled in this study. The PNI was calculated as 10 x serum albumin concentration (g/dl) + 0.005 x lymphocyte count (/mm(3)). The preoperative PNI was measured within two weeks before the operation and the postoperative PNI were measured at the first visit after leaving the hospital. We then examined the correlations between the preoperative/postoperative PNI and the prognosis for survival.
    Results: In the validation study, the median preoperative PNI was 47.90 (range: 32.45-61.36) and the median postoperative PNI was 48.69 (range: 32.62-66.96). According to the receiver operating characteristic (ROC) curve, we set 43.0 as the cut-off value in the validation study. For both the preoperative and postoperative PNI, the overall survival rates were significantly worse in the low PNI group in the validation study (preoperative PNI, rho = 0.0374; postoperative PNI, rho = 0.0005). In the multivariate analysis of the validation study, the combination of pre- and postoperative PNI was an independent predictor of poor overall survival (rho = 0.006).
    Conclusions: The postoperative PNI is, in addition to the preoperative PNI, a useful prognostic marker. The combination of pre- and postoperative PNI was an independent prognostic factor in patients with CRC who underwent potentially curative surgery and is important for considering the long-term outcome in patients with CRC.

    DOI: 10.1186/s12885-015-1537-x

  • The prognostic significance of a postoperative systemic inflammatory response in patients with colorectal cancer Reviewed

    Shibutani Masatsune, Maeda Kiyoshi, Nagahara Hisashi, Ohtani Hiroshi, Iseki Yasuhito, Ikeya Tetsuro, Sugano Kenji, Hirakawa Kosei

    WORLD JOURNAL OF SURGICAL ONCOLOGY   13   194   2015.06( ISSN:1477-7819

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    DOI: 10.1186/s12957-015-0609-3

    PubMed

  • The prognostic significance of a postoperative systemic inflammatory response in patients with colorectal cancer.

    Shibutani M, Maeda K, Nagahara H, Ohtani H, Iseki Y, Ikeya T, Sugano K, Hirakawa K

    World journal of surgical oncology   13   194   2015.06

  • The prognostic significance of a postoperative systemic inflammatory response in patients with colorectal cancer.

    World J Surg Oncology   2015.06

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  • The pretreatment Controlling Nutritional Status (CONUT) score as an independent prognostic factor in patients with clinical Stage I-III esophageal squamous cell carcinoma Reviewed

    Toyokawa T., Kubo N., Shibutani M., Sakurai K., Nagahara H., Tanaka H., Muguruma K., Ohtani H., Yashiro M., Maeda K., Ohira M., Hirakawa K.

    ANNALS OF ONCOLOGY   26   2015.06( ISSN:0923-7534

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    DOI: 10.1093/annonc/mdv233.45

  • The pretreatment Controlling Nutritional Status (CONUT) score as an independent prognostic factor in patients with clinical Stage I-III esophageal squamous cell carcinoma Reviewed

    T. Toyokawa, N. Kubo, M. Shibutani, K. Sakurai, H. Nagahara, H. Tanaka, K. Muguruma, H. Ohtani, M. Yashiro, K. Maeda, M. Ohira, K. Hirakawa

    ANNALS OF ONCOLOGY   26   2015.06( ISSN:0923-7534

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    DOI: 10.1093/annonc/mdv233.45

  • The prognostic significance of a postoperative systemic inflammatory response in patients with colorectal cancer Reviewed

    Masatsune Shibutani, Kiyoshi Maeda, Hisashi Nagahara, Hiroshi Ohtani, Yasuhito Iseki, Tetsuro Ikeya, Kenji Sugano, Kosei Hirakawa

    WORLD JOURNAL OF SURGICAL ONCOLOGY   13   194   2015.06( ISSN:1477-7819

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    Background: Recently, a preoperative systemic inflammatory response has been reported to be a prognostic factor in patients with colorectal cancer (CRC). However, the prognostic significance of a systemic inflammatory response in the early stage after surgery in patients with CRC is unknown. The aim of this retrospective study was to evaluate the prognostic significance of a postoperative systemic inflammatory response in patients with CRC.
    Methods: Two hundred and fifty-four patients who underwent potentially curative surgery for stage II/III CRC were enrolled in this study. Univariate and multivariate analyses were performed to evaluate the relationship between the prognosis and clinicopathological factors, including the neutrophil-to-lymphocyte ratio (NLR) and Glasgow Prognostic Score (GPS), which were measured within two weeks before operation and at the first visit after leaving the hospital.
    Results: The overall survival rates were significantly worse in the high preoperative NLR/preoperative GPS/postoperative NLR group. A multivariate analysis indicated that only preoperative GPS, postoperative NLR, and the number of lymph node metastases were independent prognostic factors for a poor survival.
    Conclusions: The postoperative NLR is an independent prognostic factor in patients with CRC who underwent potentially curative surgery.

    DOI: 10.1186/s12957-015-0609-3

    PubMed

  • The prognostic significance of a postoperative systemic inflammatory response in patients with colorectal cancer

    Masatsune Shibutani, Kiyoshi Maeda, Hisashi Nagahara, Hiroshi Ohtani, Yasuhito Iseki, Tetsuro Ikeya, Kenji Sugano, Kosei Hirakawa

    WORLD JOURNAL OF SURGICAL ONCOLOGY   13   2015.06( ISSN:1477-7819

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    Background: Recently, a preoperative systemic inflammatory response has been reported to be a prognostic factor in patients with colorectal cancer (CRC). However, the prognostic significance of a systemic inflammatory response in the early stage after surgery in patients with CRC is unknown. The aim of this retrospective study was to evaluate the prognostic significance of a postoperative systemic inflammatory response in patients with CRC.
    Methods: Two hundred and fifty-four patients who underwent potentially curative surgery for stage II/III CRC were enrolled in this study. Univariate and multivariate analyses were performed to evaluate the relationship between the prognosis and clinicopathological factors, including the neutrophil-to-lymphocyte ratio (NLR) and Glasgow Prognostic Score (GPS), which were measured within two weeks before operation and at the first visit after leaving the hospital.
    Results: The overall survival rates were significantly worse in the high preoperative NLR/preoperative GPS/postoperative NLR group. A multivariate analysis indicated that only preoperative GPS, postoperative NLR, and the number of lymph node metastases were independent prognostic factors for a poor survival.
    Conclusions: The postoperative NLR is an independent prognostic factor in patients with CRC who underwent potentially curative surgery.

    DOI: 10.1186/s12957-015-0609-3

  • The pretreatment albumin to globulin ratio predicts chemotherapeutic outcomes in patients with unresectable metastatic colorectal cancer Reviewed

    Shibutani Masatsune, Maeda Kiyoshi, Nagahara Hisashi, Ohtani Hiroshi, Iseki Yasuhito, Ikeya Tetsuro, Sugano Kenji, Hirakawa Kosei

    BMC CANCER   15   347   2015.05( ISSN:1471-2407

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    DOI: 10.1186/s12885-015-1375-x

    PubMed

  • The pretreatment albumin to globulin ratio predicts chemotherapeutic outcomes in patients with unresectable metastatic colorectal cancer.

    Shibutani M, Maeda K, Nagahara H, Ohtani H, Iseki Y, Ikeya T, Sugano K, Hirakawa K

    BMC cancer   15   347   2015.05

  • The pretreatment albumin to globulin ratio predicts chemotherapeutic outcomes in patients with unresectable metastatic colorectal cancer.

    BMC cancer   2015.05

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  • The pretreatment albumin to globulin ratio predicts chemotherapeutic outcomes in patients with unresectable metastatic colorectal cancer Reviewed

    Masatsune Shibutani, Kiyoshi Maeda, Hisashi Nagahara, Hiroshi Ohtani, Yasuhito Iseki, Tetsuro Ikeya, Kenji Sugano, Kosei Hirakawa

    BMC CANCER   15   347   2015.05( ISSN:1471-2407

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    Background: The pretreatment albumin to globulin ratio (AGR) has been reported to correlate with the long-term survival in patients with various cancers. However, there are no reports regarding the correlation between the pretreatment AGR and chemotherapeutic outcomes in patients with unresectable metastatic colorectal cancer. The aim of this study was to evaluate the prognostic significance of the pretreatment AGR in patients with unresectable metastatic colorectal cancer.
    Methods: A total of 66 patients with unresectable metastatic colorectal cancer who underwent palliative chemotherapy for metastatic tumors were enrolled. The AGR was calculated as follows: Albumin/(Total protein - Albumin).
    Results: The median pretreatment AGR was 1.254 (range: 0.849-1.840). We set 1.25 as the cut-off value based on the receiver operating characteristic curve. Based on the cut-off value of 1.25, 34 patients were classified into the high-AGR group and 32 patients were classified into the low-AGR group. The high-AGR group had a significantly higher chemotherapeutic disease control rate (p = 0.040) and better progression-free survival (p = 0.0171) and overall survival (p = 0.0360) rates than the low-AGR group. According to a multivariate analysis of survival, the AGR was identified to be an independent prognostic factor for progression-free survival (Hazard Ratio: 2.662, 95% Confidence Interval: 1.085-6.631, p = 0.033) and overall survival (Hazard Ratio: 2.247, 95% Confidence Interval: 1.069-4.722, p = 0.033).
    Conclusions: The pretreatment AGR is a useful prognostic marker in patients with unresectable metastatic colorectal cancer who receive palliative chemotherapy.

    DOI: 10.1186/s12885-015-1375-x

    PubMed

  • The pretreatment albumin to globulin ratio predicts chemotherapeutic outcomes in patients with unresectable metastatic colorectal cancer

    Masatsune Shibutani, Kiyoshi Maeda, Hisashi Nagahara, Hiroshi Ohtani, Yasuhito Iseki, Tetsuro Ikeya, Kenji Sugano, Kosei Hirakawa

    BMC CANCER   15   2015.05( ISSN:1471-2407

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    Background: The pretreatment albumin to globulin ratio (AGR) has been reported to correlate with the long-term survival in patients with various cancers. However, there are no reports regarding the correlation between the pretreatment AGR and chemotherapeutic outcomes in patients with unresectable metastatic colorectal cancer. The aim of this study was to evaluate the prognostic significance of the pretreatment AGR in patients with unresectable metastatic colorectal cancer.
    Methods: A total of 66 patients with unresectable metastatic colorectal cancer who underwent palliative chemotherapy for metastatic tumors were enrolled. The AGR was calculated as follows: Albumin/(Total protein - Albumin).
    Results: The median pretreatment AGR was 1.254 (range: 0.849-1.840). We set 1.25 as the cut-off value based on the receiver operating characteristic curve. Based on the cut-off value of 1.25, 34 patients were classified into the high-AGR group and 32 patients were classified into the low-AGR group. The high-AGR group had a significantly higher chemotherapeutic disease control rate (p = 0.040) and better progression-free survival (p = 0.0171) and overall survival (p = 0.0360) rates than the low-AGR group. According to a multivariate analysis of survival, the AGR was identified to be an independent prognostic factor for progression-free survival (Hazard Ratio: 2.662, 95% Confidence Interval: 1.085-6.631, p = 0.033) and overall survival (Hazard Ratio: 2.247, 95% Confidence Interval: 1.069-4.722, p = 0.033).
    Conclusions: The pretreatment AGR is a useful prognostic marker in patients with unresectable metastatic colorectal cancer who receive palliative chemotherapy.

    DOI: 10.1186/s12885-015-1375-x

  • Prognostic significance of the preoperative serum C-reactive protein level in patients with stage IV colorectal cancer.

    Surg Today   2015.03

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  • IV期結腸直腸癌患者における術前血清C反応性蛋白値の予後的意義(Prognostic significance of the preoperative serum C-reactive protein level in patients with stage IV colorectal cancer) Reviewed

    Shibutani Masatsune, Maeda Kiyoshi, Nagahara Hisashi, Noda Eiji, Ohtani Hiroshi, Nishiguchi Yukio, Hirakawa Kosei

    シュプリンガー・ジャパン(株) Surgery Today   45 ( 3 )   315 - 321   2015.03( ISSN:0941-1291

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    IV期結腸直腸癌患者における術前血清C反応性蛋白(CRP)値の臨床的意義について検討した。IV期結腸直腸癌に対する手術を受けた144症例を対象とした。血清CRP値が1.0mg/dLの患者53例を高CRP患者に分類した。術前血清CRP値と生存との関連性を後向きに評価した。CRP値が高い患者の癌特異的生存は、CRP値が低い患者より有意に不良であった。多変量解析により、治癒可能性(非根治的手術)、転移臓器数(複数臓器)、腫瘍の直径(5cm以上)、リンパ管浸潤、組織学的分化度(未分化型)、CRP値高値(1.0mg/dL以上)が、生存転帰不良の独立危険因子であった。

  • Prognostic significance of the preoperative serum C-reactive protein level in patients with stage IV colorectal cancer Reviewed

    Shibutani Masatsune, Maeda Kiyoshi, Nagahara Hisashi, Noda Eiji, Ohtani Hiroshi, Nishiguchi Yukio, Hirakawa Kosei

    SURGERY TODAY   45 ( 3 )   315 - 321   2015.03( ISSN:0941-1291

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00595-014-0909-1

    PubMed

  • Prognostic significance of the preoperative serum C-reactive protein level in patients with stage IV colorectal cancer.

    Shibutani M, Maeda K, Nagahara H, Noda E, Ohtani H, Nishiguchi Y, Hirakawa K

    Surgery today   45 ( 3 )   315 - 21   2015.03( ISSN:0941-1291

  • Prognostic significance of the preoperative serum C-reactive protein level in patients with stage IV colorectal cancer

    Masatsune Shibutani, Kiyoshi Maeda, Hisashi Nagahara, Eiji Noda, Hiroshi Ohtani, Yukio Nishiguchi, Kosei Hirakawa

    SURGERY TODAY   45 ( 3 )   315 - 321   2015.03( ISSN:0941-1291

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    Purpose Previous studies have revealed that an elevated preoperative serum C-reactive protein (CRP) level is associated with a poor prognosis in patients with various malignant tumors. The aim of this study was to determine the clinical significance of the preoperative serum CRP level in patients with stage IV colorectal cancer.
    Methods We enrolled 144 patients who underwent surgery for stage IV colorectal cancer. A total of 53 patients with a serum CRP level of &gt;= 1.0 mg/dl were classified as the high CRP individuals. The association between the preoperative serum CRP level and survival was retrospectively assessed.
    Results The cancer-specific survival of the patients with a high CRP level was significantly worse than that of the patients with a low CRP level. A multivariate analysis indicated that the curability (non-curative surgery), the number of organs with metastasis (more than one organ), the tumor diameter (&gt;= 5 cm), lymphatic involvement, histological differentiation (non-differentiated) and a high CRP level (&gt;= 1.0 mg/dl) were independent risk factors for a poor survival.
    Conclusions A high preoperative serum CRP level is a convenient biomarker for identifying patients with a poor prognosis for stage IV colorectal cancer.

    DOI: 10.1007/s00595-014-0909-1

  • Prognostic significance of the preoperative serum C-reactive protein level in patients with stage IV colorectal cancer Reviewed

    Masatsune Shibutani, Kiyoshi Maeda, Hisashi Nagahara, Eiji Noda, Hiroshi Ohtani, Yukio Nishiguchi, Kosei Hirakawa

    SURGERY TODAY   45 ( 3 )   315 - 321   2015.03( ISSN:0941-1291

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    Purpose Previous studies have revealed that an elevated preoperative serum C-reactive protein (CRP) level is associated with a poor prognosis in patients with various malignant tumors. The aim of this study was to determine the clinical significance of the preoperative serum CRP level in patients with stage IV colorectal cancer.
    Methods We enrolled 144 patients who underwent surgery for stage IV colorectal cancer. A total of 53 patients with a serum CRP level of &gt;= 1.0 mg/dl were classified as the high CRP individuals. The association between the preoperative serum CRP level and survival was retrospectively assessed.
    Results The cancer-specific survival of the patients with a high CRP level was significantly worse than that of the patients with a low CRP level. A multivariate analysis indicated that the curability (non-curative surgery), the number of organs with metastasis (more than one organ), the tumor diameter (&gt;= 5 cm), lymphatic involvement, histological differentiation (non-differentiated) and a high CRP level (&gt;= 1.0 mg/dl) were independent risk factors for a poor survival.
    Conclusions A high preoperative serum CRP level is a convenient biomarker for identifying patients with a poor prognosis for stage IV colorectal cancer.

    DOI: 10.1007/s00595-014-0909-1

    PubMed

  • IV期結腸直腸癌患者における術前血清C反応性蛋白値の予後的意義(Prognostic significance of the preoperative serum C-reactive protein level in patients with stage IV colorectal cancer)

    Shibutani Masatsune, Maeda Kiyoshi, Nagahara Hisashi, Noda Eiji, Ohtani Hiroshi, Nishiguchi Yukio, Hirakawa Kosei

    Surgery Today   45 ( 3 )   315 - 321   2015.03( ISSN:0941-1291

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    IV期結腸直腸癌患者における術前血清C反応性蛋白(CRP)値の臨床的意義について検討した。IV期結腸直腸癌に対する手術を受けた144症例を対象とした。血清CRP値が1.0mg/dLの患者53例を高CRP患者に分類した。術前血清CRP値と生存との関連性を後向きに評価した。CRP値が高い患者の癌特異的生存は、CRP値が低い患者より有意に不良であった。多変量解析により、治癒可能性(非根治的手術)、転移臓器数(複数臓器)、腫瘍の直径(5cm以上)、リンパ管浸潤、組織学的分化度(未分化型)、CRP値高値(1.0mg/dL以上)が、生存転帰不良の独立危険因子であった。

  • Expression of xCT as a Predictor of Disease Recurrence in Patients with Colorectal Cancer Reviewed

    Sugano Kenji, Maeda Kiyoshi, Ohtani Hiroshi, Nagahara Hisashi, Shibutani Masatsune, Hirakawa Kosei

    ANTICANCER RESEARCH   35 ( 2 )   677 - 682   2015.02( ISSN:0250-7005

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  • Maintenance of the nutritional prognostic index predicts survival in patients with unresectable metastatic colorectal cancer Reviewed

    Ikeya Tetsuro, Shibutani Masatsune, Maeda Kiyoshi, Sugano Kenji, Nagahara Hisashi, Ohtani Hiroshi, Hirakawa Kosei

    JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY   141 ( 2 )   307 - 313   2015.02( ISSN:0171-5216

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    DOI: 10.1007/s00432-014-1799-8

    PubMed

  • Impact of Body Mass Index on Surgical Outcomes after Esophagectomy for Patients with Esophageal Squamous Cell Carcinoma Reviewed

    Hasegawa Tsuyoshi, Kubo Naoshi, Ohira Masaichi, Sakurai Katsunobu, Toyokawa Takahiro, Yamashita Yoshito, Yamazoe Sadaaki, Kimura Kenjiro, Nagahara Hisashi, Amano Ryosuke, Shibutani Masatsune, Tanaka Hiroaki, Muguruma Kazuya, Ohtani Hiroshi, Yashiro Masakazu, Maeda Kiyoshi, Hirakawa Kosei

    JOURNAL OF GASTROINTESTINAL SURGERY   19 ( 2 )   226 - 233   2015.02( ISSN:1091-255X

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    DOI: 10.1007/s11605-014-2686-y

    PubMed

  • Expression of xCT as a predictor of disease recurrence in patients with colorectal cancer. Reviewed

    Sugano K, Maeda K, Ohtani H, Nagahara H, Shibutani M, Hirakawa K

    Anticancer research   35 ( 2 )   677 - 82   2015.02( ISSN:0250-7005

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    PubMed

  • Maintenance of the nutritional prognostic index predicts survival in patients with unresectable metastatic colorectal cancer Reviewed

    Tetsuro Ikeya, Masatsune Shibutani, Kiyoshi Maeda, Kenji Sugano, Hisashi Nagahara, Hiroshi Ohtani, Kosei Hirakawa

    JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY   141 ( 2 )   307 - 13   2015.02( ISSN:0171-5216

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    Nutrition and immunity significantly affect the progression of cancer in cancer patients. Therefore, the evaluation of the nutritional and immune status would be useful as a prognostic factor and to determine the optimal treatment strategy for patients with unresectable metastatic colorectal cancer who are receiving chemotherapy. The aim of this retrospective study was to evaluate the prognostic significance of the nutritional and immune status in patients with unresectable metastatic colorectal cancer treated with chemotherapy.
    We retrospectively reviewed 80 patients with colorectal cancer. A total of 22 patients had metachronous unresectable cancer, and 58 patients had synchronous unresectable cancer. All patients underwent combination chemotherapy with oxaliplatin or irinotecan plus 5-fluorouracil/leucovorin as first-line chemotherapy. We then examined the correlations between the Onodera's prognostic nutritional index (OPNI) and the patients' clinicopathological features. The OPNI was calculated as follows: 10 x serum albumin (g/dl) + 0.005 x total lymphocyte count (per mm(3)). According to the receiver operating characteristic (ROC) curve analysis, the cutoff value for OPNI was 44.5.
    Patients with a pretreatment OPNI of a parts per thousand 44.5 demonstrated a longer OS than those with a pretreatment OPNI of &lt; 44.5. Moreover, we categorized these patients into four groups according to the combination of the pre- and post-treatment OPNI. The patients in the group with both OPNIs a parts per thousand yen44.5 exhibited a better prognosis compared to the other group (p = 0.001).
    The OPNI is considered to be a useful marker for predicting the long-term outcome in patients who receive chemotherapy for unresectable metastatic colorectal cancer.

    DOI: 10.1007/s00432-014-1799-8

    PubMed

  • Impact of Body Mass Index on Surgical Outcomes after Esophagectomy for Patients with Esophageal Squamous Cell Carcinoma Reviewed

    Tsuyoshi Hasegawa, Naoshi Kubo, Masaichi Ohira, Katsunobu Sakurai, Takahiro Toyokawa, Yoshito Yamashita, Sadaaki Yamazoe, Kenjiro Kimura, Hisashi Nagahara, Ryosuke Amano, Masatsune Shibutani, Hiroaki Tanaka, Kazuya Muguruma, Hiroshi Ohtani, Masakazu Yashiro, Kiyoshi Maeda, Kosei Hirakawa

    JOURNAL OF GASTROINTESTINAL SURGERY   19 ( 2 )   226 - 33   2015.02( ISSN:1091-255X

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    Patients with overweight reportedly have more comorbidities, including diabetes mellitus and cardiovascular disease, and longer operating times as well as more blood loss during surgery compared with those with normal weight. However, the impact of overweight on the short-term outcome after transthoracic esophagectomy for patients with esophageal squamous cell carcinoma (ESCC) remains unclear. We hypothesized that overweight has a negative impact on short-term surgical outcomes after esophagectomy for patients with ESCC.
    A total of 304 patients who underwent transthoracic esophagectomy for ESCC were included in this study. Body mass index (BMI) was classified into three categories, &lt; 18.49, 18.50-24.99, and &gt; 25.00 (kg/m(2)), defined as low, normal, and high BMI, respectively, according to the World Health Organization criteria. We investigated the association of BMI status with patient demographics and surgical outcomes after esophagectomy for patients with ESCC. In addition, overall survival and relapse-free survival stratified by BMI were compared.
    Fifty-nine (19.4 %) and 41 (13.4 %) patients were classified to low BMI and high BMI, respectively. The high-BMI group had significantly higher comorbidity rates of diabetes mellitus (p &lt; 0.01) and anastomotic leakage (p = 0.011) than the normal-BMI group. There were no significant association between high BMI and another various complications except for an anastomotic leakage, severe complications defined by Clavien-Dindo classification and in-hospital mortality. In multivariate analysis, high BMI was a significant risk factor for anastomotic leakage (p = 0.030, hazard ratio; 3.423, 95%CI; 1.128-10.38). On the other hand, no significant association was observed between low BMI and short surgical outcomes. There were no significant differences in overall and relapse-free survival among the three BMI groups in univariate and multivariate analysis (p = 0.128 and p = 0.584, respectively).
    The surgical treatment should not be denied for patients with ESCC due to overweight and underweight. However, intraoperative prevention and postoperative careful monitoring for anastomotic leakage might be required after esophagectomy for overweight patients with ESCC.

    DOI: 10.1007/s11605-014-2686-y

    PubMed

  • Expression of xCT as a predictor of disease recurrence in patients with colorectal cancer.

    Sugano K, Maeda K, Ohtani H, Nagahara H, Shibutani M, Hirakawa K

    Anticancer research   35 ( 2 )   677 - 82   2015.02( ISSN:0250-7005

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  • Expression of xCT as a predictor of disease recurrence in patients with colorectal cancer. Reviewed

    Sugano K, Maeda K, Ohtani H, Nagahara H, Shibutani M, Hirakawa K

    Anticancer research   35 ( 2 )   677 - 82   2015.02( ISSN:0250-7005

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    PubMed

  • Expression of xCT as a Predictor of Disease Recurrence in Patients with Colorectal Cancer Reviewed

    Kenji Sugano, Kiyoshi Maeda, Hiroshi Ohtani, Hisashi Nagahara, Masatsune Shibutani, Kosei Hirakawa

    ANTICANCER RESEARCH   35 ( 2 )   677 - 682   2015.02( ISSN:0250-7005

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    Background: The function of a cysteine-glutamate exchanger (xCT) transporter is to increase the intracellular concentration of glutathione in order to protect cells from oxidative stress. In several types of cancer, xCT is thought to play a role in the onset of resistance to chemotherapy and radiotherapy. xCT is stabilized on the tumor cell surface after combining with cluster of differentiation 44 variant (CD44v). Materials and Methods: We examined the xCT and CD44v6 expression in 304 primary tumor samples obtained from patients with colorectal cancer using immunohistochemical analysis. Results: Immunoreactivity for xCT was observed in 208 (68.4%) tumors. Among 218 patients with stage I-III disease who underwent curative surgery, the postoperative recurrence rate was 32.9% in those with xCT-positive tumors, which was significantly (p = 0.003) higher than in those with xCT-negative tumors (10.7%). Immunoreactivity for CD44v6 was observed in 101 cases (33.2%), although the rate of postoperative recurrence in patients with CD44v6-positive tumors did not exhibit any significant correlation. Multivariate analyses revealed increased xCT expression to be an independent significant predictor of disease recurrence, in addition to depth of tumor invasion, lymph node metastasis and venous invasion.

  • Clinical significance of node infiltrating tumor–associated macrophage in gastric cancer Reviewed

    Tauchi Yukie, Tanaka Hiroaki, Sakimura Chie, Tokumoto Mao, Shibutani Masatsune, Yamazoe Sadaaki, Sakurai Katsunobu, Nagahara Hisashi, Kimura Kenjiro, Toyokawa Takahiro, Amano Ryousuke, Kubo Naoshi, Muguruma Kazuya, Ohtani Hiroshi, Yashiro Masakazu, Maeda Kiyoshi, Ohira Masaichi, Hirakawa Kosei

    Japanese Society for Molecular Tumor Marker Research, Japan Journal of Molecular Tumor Marker Research   30 ( 0 )   27 - 28   2015

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    DOI: 10.11241/jsmtmr.30.27

    CiNii Article

  • Preoperative Neutrophil–to–lymphocyte Ratio is a prognostic factor of patients with colorectal cancer Reviewed

    Ikeya Tetsuro, Shibutani Masatsune, Maeda Kiyoshi, Ohtani Hiroshi, Nagahara Hisashi, Sugano Kenji, Iseki Yasuhito, Sakurai Katsunobu, Yamazoe Sadaaki, Kimura Kenjiro, Toyokawa Takahiro, Amano Ryosuke, Kubo Naoshi, Tanaka Hiroaki, Muguruma Kazuya, Ohira Masaichi, Hirakawa Kosei

    Japanese Society for Molecular Tumor Marker Research, Japan Journal of Molecular Tumor Marker Research   30 ( 0 )   25 - 26   2015

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    DOI: 10.11241/jsmtmr.30.25

    CiNii Article

  • A Case of Meckel's Diverticulum Perforation Caused by Deviation of the Ileus Tube Reviewed

    TOGANO Shingo, SHIBUTANI Masatsune, MAEDA Kiyoshi, NAGAHARA Hisashi, OHTANI Hiroshi, HIRAKAWA Kosei

    Japan Surgical Association, The journal of the Japanese Practical Surgeon Society   76 ( 5 )   1048 - 1052   2015( ISSN:1345-2843

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    A 65-year-old man who had been hospitalized for a detailed examination to assess lung cancer, developed ileus. An ileus tube was placed, and the patient reported abdominal pain with signs of peritoneal irritation on the ninth day after placement. Abdominal computed tomography was performed, which showed the presence of intra-abdominal free air. We therefore diagnosed peritonitis due to intestinal perforation and thus performed emergency surgery. During the surgery, deviation of the ileus tube from the top of Meckel's diverticulum was observed, and the diverticulum was found to adhere to the distal ileum, with pus production. We therefore diagnosed diverticulitis, adhesion ileus, and Meckel's diverticulum perforation and performed a local enterectomy including the diverticulum. Meckel's diverticulum is a congenital intestinal abnormality. Most patients are a symptomatic ; however, rarely, diverticulitis, ileus, and/or perforation may be noted. We present an extremely rare case of Meckel's diverticulum perforation by an ileus tube placed to treat the adhesion ileus due to Meckel's diverticulitis. We herein report this case with a review of the previous literature.

    DOI: 10.3919/jjsa.76.1048

    CiNii Article

  • Impact of the Preoperative Controlling Nutritional Status (CONUT) Score on the Survival after Curative Surgery for Colorectal Cancer Reviewed

    Yasuhito Iseki, Masatsune Shibutani, Kiyoshi Maeda, Hisashi Nagahara, Hiroshi Ohtani, Kenji Sugano, Tetsuro Ikeya, Kazuya Muguruma, Hiroaki Tanaka, Takahiro Toyokawa, Katsunobu Sakurai, Kosei Hirakawa

    PLOS ONE   10 ( 7 )   e0132488   2015( ISSN:1932-6203

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    Background
    Recently, the preoperative immune-nutritional status has been reported to correlate with the survival rate in patients with colorectal cancer (CRC). However, there have been no reports on the relationship between the controlling nutritional status (CONUT) score and the clinical outcome after curative surgery for CRC. We herein evaluated the prognostic significance of the CONUT score in patients with CRC, and then compared the accuracy of the CONUT score and the prognostic nutritional index (PNI) as a predictor of survival.
    Methods
    We retrospectively reviewed a database of 204 patients who underwent curative surgery for Stage II/ III CRC. Patients were divided into two groups according to the CONUT score and the PNI.
    Results
    The five-year cancer-specific survival (CSS) rate was significantly higher at 92.7% in the low CONUT group, compared to a rate of 81.0% in the high CONUT group (p=0.0016). The five-year CSS was 71.2% in the low PNI group and 92.3% in the high PNI group, which showed a significant difference (p=0.0155). A multivariate analysis showed that lymph node metastasis and the CONUT score were independent risk factors for CSS.
    Conclusion
    This study suggested that the CONUT score is a strong independent predictor of the survival among CRC patients.

    DOI: 10.1371/journal.pone.0132488

    PubMed

  • Clinical significance of node infiltrating tumor–associated macrophage in gastric cancer Reviewed

    Tauchi Yukie, Tanaka Hiroaki, Sakimura Chie, Tokumoto Mao, Shibutani Masatsune, Yamazoe Sadaaki, Sakurai Katsunobu, Nagahara Hisashi, Kimura Kenjiro, Toyokawa Takahiro, Amano Ryousuke, Kubo Naoshi, Muguruma Kazuya, Ohtani Hiroshi, Yashiro Masakazu, Maeda Kiyoshi, Ohira Masaichi, Hirakawa Kosei

    Japan Journal of Molecular Tumor Marker Research   30 ( 0 )   27 - 28   2015

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    DOI: 10.11241/jsmtmr.30.27

    CiNii Article

  • A Case of Meckel's Diverticulum Perforation Caused by Deviation of the Ileus Tube

    TOGANO Shingo, SHIBUTANI Masatsune, MAEDA Kiyoshi, NAGAHARA Hisashi, OHTANI Hiroshi, HIRAKAWA Kosei

    Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association)   76 ( 5 )   1048 - 1052   2015( ISSN:13452843

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    Publishing type:Research paper (scientific journal)  

    A 65-year-old man who had been hospitalized for a detailed examination to assess lung cancer, developed ileus. An ileus tube was placed, and the patient reported abdominal pain with signs of peritoneal irritation on the ninth day after placement. Abdominal computed tomography was performed, which showed the presence of intra-abdominal free air. We therefore diagnosed peritonitis due to intestinal perforation and thus performed emergency surgery. During the surgery, deviation of the ileus tube from the top of Meckel's diverticulum was observed, and the diverticulum was found to adhere to the distal ileum, with pus production. We therefore diagnosed diverticulitis, adhesion ileus, and Meckel's diverticulum perforation and performed a local enterectomy including the diverticulum. Meckel's diverticulum is a congenital intestinal abnormality. Most patients are a symptomatic ; however, rarely, diverticulitis, ileus, and/or perforation may be noted. We present an extremely rare case of Meckel's diverticulum perforation by an ileus tube placed to treat the adhesion ileus due to Meckel's diverticulitis. We herein report this case with a review of the previous literature.

    DOI: 10.3919/jjsa.76.1048

    CiNii Article

  • Preoperative Neutrophil–to–lymphocyte Ratio is a prognostic factor of patients with colorectal cancer Reviewed

    Ikeya Tetsuro, Shibutani Masatsune, Maeda Kiyoshi, Ohtani Hiroshi, Nagahara Hisashi, Sugano Kenji, Iseki Yasuhito, Sakurai Katsunobu, Yamazoe Sadaaki, Kimura Kenjiro, Toyokawa Takahiro, Amano Ryosuke, Kubo Naoshi, Tanaka Hiroaki, Muguruma Kazuya, Ohira Masaichi, Hirakawa Kosei

    Japan Journal of Molecular Tumor Marker Research   30 ( 0 )   25 - 26   2015

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    DOI: 10.11241/jsmtmr.30.25

    CiNii Article

  • A case of desmoid tumor and advanced sigmoid colon cancer with liver metastasis in familial adenomatous polyposis (FAP) Reviewed

    Koji Takada, Kiyoshi Maeda, Hiroshi Otani, Hisashi Nagahara, Eiji Noda, Masatsune Shibutani, Mao Tokumoto, Sadaaki Yamazoe, Kenjiro Kimura, Takahiro Toyokawa, Ryosuke Amano, Naosi Kubo, Hiroaki Tanaka, Kazuya Muguruma, Masaichi Ohira, Kosei Hirakawa

    Japanese Journal of Cancer and Chemotherapy   41 ( 12 )   1767 - 1769   2014.11( ISSN:0385-0684

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    We report on a 30-year-old man with familial adenomatous polyposis (FAP) who developed advanced sigmoid colon cancer with desmoid tumors. The patient initially presented with melena. FAP advanced sigmoid colon cancer was diagnosed following a laparoscopy-assisted proctocolectomy in 2007. A computed tomography (CT) scan, conducted 7 months later, revealed a tumor around the branch of the common iliac artery. We diagnosed sigmoid colon cancer recurrence and attempted treatment by surgical removal. However, there were many smooth tumors within the patient's abdomen, which were diagnosed as desmoid tumors using rapid intraoperative pathological diagnosis. Although the patient was administered a COX-2 inhibitor and tamoxifen after surgery, the tumor grew. Dacarbazine (DTIC) and doxorubicin (DOX) were subsequently administered to the patient, and after 4 courses, the tumor was reduced by 60% and stable disease (SD) was achieved. In 2009, a CT scan indicated sigmoid colon cancer recurrence in the liver. The patient underwent a left hepatic lobectomy by laparoscopy-assisted surgery. To date, 4 years and 6 months after surgery, we have been unable to find new disease or desmoid tumor growth.

    PubMed

  • Effect of recombinant human soluble thrombomodulin in patients with solid carcinoma with DIC Reviewed

    Yuka Asano, Shinichiro Kashiwagi, Masatsune Shibutani, Sadaaki Yamazoe, Satoru Noda, Katsunobu Sakurai, Hisashi Nagahara, Kenjiro Kimura, Hidemi Kawajiri, Takahiro Toyokawa, Ryosuke Amano, Naoshi Kubo, Hiroaki Tanaka, Kazuya Muguruma, Hiroshi Ohtani, Tsutomu Takashima, Masakazu Yashiro, Naoyoshi Onoda, Kiyoshi Maeda, Masaichi Ohira, Kosei Hirakawa

    Japanese Journal of Cancer and Chemotherapy   41 ( 12 )   2503 - 2505   2014.11( ISSN:0385-0684

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    There are only a few reports in the literature about the effect of recombinant human soluble thrombomodulin (rTM) in Patients with solid carcinoma with disseminated intravascular coagulation (DIC). A retrospective study of 40 patients with solid carcinoma with DIC was performed between February 2009 and April 2013. The withdrawal rate was 32.5% (13/40 Patients) and the 28-day survival rate was 40.0% (16/40 patients). Patients with successful withdrawal of DIC had significantly better outcomes (p&lt
    0.001). Therapy with rTM is one of the treatment options for patients with solid carcinoma with DIC.

    PubMed

  • A case of lymph node recurrence occurring nine years after surgery for sigmoid colon cancer Reviewed

    Shingo Togano, Masatsune Shibutani, Kiyoshi Maeda, Masakazu Yashiro, Hisashi Nagahara, Hiroshi Ohtani, Katsunobu Sakurai, Sadaaki Yamazoe, Kenjiro Kimura, Takahiro Toyokawa, Ryosuke Amano, Naoshi Kubo, Hiroaki Tanaka, Kazuya Muguruma, Masaichi Ohira, Kosei Hirakawa

    Japanese Journal of Cancer and Chemotherapy   41 ( 12 )   1614 - 1616   2014.11( ISSN:0385-0684

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    A 64-year-old man underwent sigmoidectomy for sigmoid colon cancer 9 years ago. We attempted to discontinue surveillance, as the postoperative course was event free for 5 years
    however, we continued the follow-up on the patient's request. Nine years after the operation, elevation of the serum carcinoembryonic antigen (CEA) level was detected, and positron emission tomography-computed tomography (PET-CT) showed a 35-mm mass with an abnormal signal (SUVmax 18.6 Bq/mL). We performed an abdominal CT and magnetic resonance imaging and found the mass invading the sigmoid colon. We suspected lymph node recurrence of the sigmoid colon cancer and considered curative surgery to be appropriate as there were no other signs of recurrence. We therefore excised the tumor by sigmoidectomy. A histopathological examination revealed metastatic adenocarcinoma in the lymph node. One year after the second operation, there was no evidence of recurrence on imaging and the levels of tumor markers were within the normal limits. Few reports have documented recurrence over 5 years after surgery. We herein describe our case and report the characteristics of a recurrent lesion and also suggest a protocol for surveillance, taking into consideration the previous literature.

    PubMed

  • Elevated preoperative serum C-reactive protein levels are associated with poor survival in patients with colorectal cancer.

    Hepatogastroenterology   2014.11

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  • Significance of Ductal Region in Anaplastic Pancreatic Cancer Reviewed

    Miura K., Kimura K., Amano R., Yamazoe S., Ohira G., Nishio K., Shibutani M., Sakurai K., Nagahara H., Toyokawa T., Kubo N., Tanaka H., Muguruma K., Otani H., Yashiro M., Maeda K., Ohira M., Hirakawa K.

    PANCREAS   43 ( 8 )   1391 - 1391   2014.11( ISSN:0885-3177

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  • Importance of the Invasive Distance in Invasive IPMN as a Prognostic Factor Reviewed

    Kimura K., Amano R., Yamazoe S., Miura K., Ohira G., Nishio K., Shibutani M., Sakurai K., Nagahara H., Toyokawa T., Kubo N., Tanaka H., Muguruma K., Otani H., Maeda K., Ohira M., Hirakawa K.

    PANCREAS   43 ( 8 )   1379 - 1379   2014.11( ISSN:0885-3177

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  • Elevated preoperative serum C-reactive protein levels are associated with poor survival in patients with colorectal cancer. Reviewed

    Shibutani M, Maeda K, Nagahara H, Ohtani H, Sugano K, Ikeya T, Kimura K, Amano R, Kubo N, Tanaka H, Muguruma K, Ohira M, Hirakawa K

    Hepato-gastroenterology   61 ( 136 )   2236 - 40   2014.11( ISSN:0172-6390

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    PubMed

  • [Stage IV small cell esophageal carcinoma that responded to various chemotherapeutic regimens with relative longevity - a case report]. Reviewed

    Yamakoshi Y, Kubo N, Ohira M, Sakurai K, Toyokawa T, Shibutani M, Yamazoe S, Nagahara H, Kimura K, Amano R, Tanaka H, Muguruma K, Ohtani H, Yashiro M, Maeda K, Hirakawa K

    Gan to kagaku ryoho. Cancer & chemotherapy   41 ( 12 )   2021 - 3   2014.11( ISSN:0385-0684

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    PubMed

  • [Effect of recombinant human soluble thrombomodulin in patients with solid carcinoma with DIC]. Reviewed

    Asano Y, Kashiwagi S, Shibutani M, Yamazoe S, Noda S, Sakurai K, Nagahara H, Kimura K, Kawajiri H, Toyokawa T, Amano R, Kubo N, Tanaka H, Muguruma K, Ohtani H, Takashima T, Yashiro M, Onoda N, Maeda K, Ohira M, Hirakawa K

    Gan to kagaku ryoho. Cancer & chemotherapy   41 ( 12 )   2503 - 5   2014.11( ISSN:0385-0684

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    PubMed

  • [A case of lymph node recurrence occurring nine years after surgery for sigmoid colon cancer]. Reviewed

    Togano S, Shibutani M, Maeda K, Yashiro M, Nagahara H, Ohtani H, Sakurai K, Yamazoe S, Kimura K, Toyokawa T, Amano R, Kubo N, Tanaka H, Muguruma K, Ohira M, Hirakawa K

    Gan to kagaku ryoho. Cancer & chemotherapy   41 ( 12 )   1614 - 6   2014.11( ISSN:0385-0684

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    Publishing type:Research paper (scientific journal)  

    PubMed

  • [A case of desmoid tumor and advanced sigmoid colon cancer with liver metastasis in familial adenomatous polyposis (FAP)]. Reviewed

    Takada K, Maeda K, Otani H, Nagahara H, Noda E, Shibutani M, Tokumoto M, Yamazoe S, Kimura K, Toyokawa T, Amano R, Kubo N, Tanaka H, Muguruma K, Ohira M, Hirakawa K

    Gan to kagaku ryoho. Cancer & chemotherapy   41 ( 12 )   1767 - 9   2014.11( ISSN:0385-0684

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    Publishing type:Research paper (scientific journal)  

    PubMed

  • [A case of desmoid tumor and advanced sigmoid colon cancer with liver metastasis in familial adenomatous polyposis (FAP)].

    Takada K, Maeda K, Otani H, Nagahara H, Noda E, Shibutani M, Tokumoto M, Yamazoe S, Kimura K, Toyokawa T, Amano R, Kubo N, Tanaka H, Muguruma K, Ohira M, Hirakawa K

    Gan to kagaku ryoho. Cancer & chemotherapy   41 ( 12 )   1767 - 9   2014.11( ISSN:0385-0684

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  • Importance of the Invasive Distance in Invasive IPMN as a Prognostic Factor Reviewed

    K. Kimura, R. Amano, S. Yamazoe, K. Miura, G. Ohira, K. Nishio, M. Shibutani, K. Sakurai, H. Nagahara, T. Toyokawa, N. Kubo, H. Tanaka, K. Muguruma, H. Otani, K. Maeda, M. Ohira, K. Hirakawa

    PANCREAS   43 ( 8 )   1379 - 1379   2014.11( ISSN:0885-3177

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    Publishing type:Research paper (scientific journal)  

  • Elevated preoperative serum C-reactive protein levels are associated with poor survival in patients with colorectal cancer.

    Shibutani M, Maeda K, Nagahara H, Ohtani H, Sugano K, Ikeya T, Kimura K, Amano R, Kubo N, Tanaka H, Muguruma K, Ohira M, Hirakawa K

    Hepato-gastroenterology   61 ( 136 )   2236 - 40   2014.11( ISSN:0172-6390

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  • Elevated Preoperative Serum C-Reactive Protein Levels are Associated with Poor Survival in Patients with Colorectal Cancer Reviewed

    Masatsune Shibutani, Kiyoshi Maeda, Hisashi Nagahara, Hiroshi Ohtani, Kenji Sugano, Tetsuro Ikeya, Kenjiro Kimura, Ryosuke Amano, Naoshi Kubo, Hiroaki Tanaka, Kazuya Muguruma, Masaichi Ohira, Kosei Hirakawa

    HEPATO-GASTROENTEROLOGY   61 ( 136 )   2236 - 2240   2014.11( ISSN:0172-6390

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    Background/Aims: Previous studies have reported that elevated preoperative serum C-reactive protein (CRP) levels are associated with a poor prognosis in patients with various types of cancer. The aim of this study was to evaluate the prognostic significance of the preoperative serum CRP levels in patients with colorectal cancer and determine an appropriate cutoff value of the serum CRP level. Methodology: We enrolled 855 patients who underwent surgery for stage I-IV colorectal cancer. The median serum CRP level was 0.13 (range: 0.01-22.8). We set 0.6 as the cutoff value of the serum CRP level based on the receiver operating characteristic curve. The patients were classified into two groups according to the serum CRP level. The prognostic significance of an elevated serum CRP level was evaluated using a multivariate analysis. Results: The cancer-specific survival was significantly worse in the patients with a high serum CRP level. In particular, more significant differences were observed in the patients with stage IV disease. The multivariate analysis indicated that a high serum CRP level was an independent risk factor for poor survival. Conclusions: The preoperative serum CRP level is a convenient biomarker and predictor of a poor prognosis after surgery for colorectal cancer.

    DOI: 10.5754/hge13770

  • Elevated Preoperative Serum C-Reactive Protein Levels are Associated with Poor Survival in Patients with Colorectal Cancer

    Masatsune Shibutani, Kiyoshi Maeda, Hisashi Nagahara, Hiroshi Ohtani, Kenji Sugano, Tetsuro Ikeya, Kenjiro Kimura, Ryosuke Amano, Naoshi Kubo, Hiroaki Tanaka, Kazuya Muguruma, Masaichi Ohira, Kosei Hirakawa

    HEPATO-GASTROENTEROLOGY   61 ( 136 )   2236 - 2240   2014.11( ISSN:0172-6390

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    Background/Aims: Previous studies have reported that elevated preoperative serum C-reactive protein (CRP) levels are associated with a poor prognosis in patients with various types of cancer. The aim of this study was to evaluate the prognostic significance of the preoperative serum CRP levels in patients with colorectal cancer and determine an appropriate cutoff value of the serum CRP level. Methodology: We enrolled 855 patients who underwent surgery for stage I-IV colorectal cancer. The median serum CRP level was 0.13 (range: 0.01-22.8). We set 0.6 as the cutoff value of the serum CRP level based on the receiver operating characteristic curve. The patients were classified into two groups according to the serum CRP level. The prognostic significance of an elevated serum CRP level was evaluated using a multivariate analysis. Results: The cancer-specific survival was significantly worse in the patients with a high serum CRP level. In particular, more significant differences were observed in the patients with stage IV disease. The multivariate analysis indicated that a high serum CRP level was an independent risk factor for poor survival. Conclusions: The preoperative serum CRP level is a convenient biomarker and predictor of a poor prognosis after surgery for colorectal cancer.

    DOI: 10.5754/hge13770

  • [Stage IV small cell esophageal carcinoma that responded to various chemotherapeutic regimens with relative longevity - a case report].

    Yamakoshi Y, Kubo N, Ohira M, Sakurai K, Toyokawa T, Shibutani M, Yamazoe S, Nagahara H, Kimura K, Amano R, Tanaka H, Muguruma K, Ohtani H, Yashiro M, Maeda K, Hirakawa K

    Gan to kagaku ryoho. Cancer & chemotherapy   41 ( 12 )   2021 - 3   2014.11( ISSN:0385-0684

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  • [Effect of recombinant human soluble thrombomodulin in patients with solid carcinoma with DIC].

    Asano Y, Kashiwagi S, Shibutani M, Yamazoe S, Noda S, Sakurai K, Nagahara H, Kimura K, Kawajiri H, Toyokawa T, Amano R, Kubo N, Tanaka H, Muguruma K, Ohtani H, Takashima T, Yashiro M, Onoda N, Maeda K, Ohira M, Hirakawa K

    Gan to kagaku ryoho. Cancer & chemotherapy   41 ( 12 )   2503 - 5   2014.11( ISSN:0385-0684

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  • [A case of lymph node recurrence occurring nine years after surgery for sigmoid colon cancer].

    Togano S, Shibutani M, Maeda K, Yashiro M, Nagahara H, Ohtani H, Sakurai K, Yamazoe S, Kimura K, Toyokawa T, Amano R, Kubo N, Tanaka H, Muguruma K, Ohira M, Hirakawa K

    Gan to kagaku ryoho. Cancer & chemotherapy   41 ( 12 )   1614 - 6   2014.11( ISSN:0385-0684

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  • Significance of Ductal Region in Anaplastic Pancreatic Cancer Reviewed

    K. Miura, K. Kimura, R. Amano, S. Yamazoe, G. Ohira, K. Nishio, M. Shibutani, K. Sakurai, H. Nagahara, T. Toyokawa, N. Kubo, H. Tanaka, K. Muguruma, H. Otani, M. Yashiro, K. Maeda, M. Ohira, K. Hirakawa

    PANCREAS   43 ( 8 )   1391 - 1391   2014.11( ISSN:0885-3177

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  • Effect of cancer associated fibroblast on gastric cancer cells under hypoxia Reviewed

    Kinoshita Haruhito, Yashiro Masakazu, Masuda Go, Kasashima Hiroaki, Morisaki Tamami, Fukuoka Tatsunari, Shibutani Masatune, Yamazoe Sadaaki, Sakurai Katsunobu, Nagahara Hisashi, Kimura Kenjiro, Toyokawa Takahiro, Amano Ryosuke, Kubo Naoshi, Tanaka Hiroaki, Muguruma Kazuya, Otani Hiroshi, Maeda Kiyoshi, Ohira Masaichi, Hirakawa Kosei

    CANCER RESEARCH   74 ( 19 )   2014.10( ISSN:0008-5472

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    DOI: 10.1158/1538-7445.AM2014-3612

  • The effect of PGE2 receptor inhibitor on the microenviroment of scirrhous gastric cancer Reviewed

    Fukuoka Tatsunari, Yashiro Masakazu, Takeda Hiroshi, Maruyama Takayuki, Kasashima Hiroaki, Masuda Go, Kinoshita Haruhito, Morisaki Tamami, Sakurai Katsunobu, Shibutani Masatsune, Yamazoe Sadaaki, Kimura Kenjiro, Nagahara Hisashi, Toyokawa Takahiro, Amano Ryosuke, Kubo Naoshi, Tanaka Hiroaki, Muguruma Kazuya, Otani Hiroshi, Maeda Kiyoshi, Ohira Masaichi, Hirakawa Kosei

    CANCER RESEARCH   74 ( 19 )   2014.10( ISSN:0008-5472

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    DOI: 10.1158/1538-7445.AM2014-3606

  • Extent of intranodal macrophage correlates with lymph node metastasis of gastric cancer Reviewed

    Go Yukie, Tanaka Hiroaki, Tokumoto Mao, Okita Yoshihiro, Shibutani Masatsune, Yamazoe Sadaaki, Sakurai Katsunobu, Nagahara Hisashi, Kimura Kenjiro, Toyokawa Takahiro, Amano Ryosuke, Kubo Naoshi, Muguruma Kazuya, Otani Hiroshi, Yashiro Masakazu, Maeda Kiyoshi, Ohira Masaichi, Hirakawa Kosei

    CANCER RESEARCH   74 ( 19 )   2014.10( ISSN:0008-5472

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    DOI: 10.1158/1538-7445.AM2014-1081

  • Establishment and characterization of two cell lines of anaplastic pancreatic cancer Reviewed

    Miura Kotaro, Kimura Kenjiro, Amano Ryosuke, Yamazoe Sadaaki, Hirata Keiichiro, Shibutani Masatsune, Sakurai Katsunobu, Nagahara Hisashi, Toyokawa Takahiro, Kubo Naoshi, Tanaka Hiroaki, Muguruma Kazuya, Otani Hiroshi, Yashiro Masakazu, Maeda Kiyoshi, Ohira Masaichi, Hirakawa Kosei

    CANCER RESEARCH   74 ( 19 )   2014.10( ISSN:0008-5472

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    DOI: 10.1158/1538-7445.AM2014-3924

  • Effect of cancer associated fibroblast on gastric cancer cells under hypoxia Reviewed

    Haruhito Kinoshita, Masakazu Yashiro, Go Masuda, Hiroaki Kasashima, Tamami Morisaki, Tatsunari Fukuoka, Masatune Shibutani, Sadaaki Yamazoe, Katsunobu Sakurai, Hisashi Nagahara, Kenjiro Kimura, Takahiro Toyokawa, Ryosuke Amano, Naoshi Kubo, Hiroaki Tanaka, Kazuya Muguruma, Hiroshi Otani, Kiyoshi Maeda, Masaichi Ohira, Kosei Hirakawa

    CANCER RESEARCH   74 ( 19 )   2014.10( ISSN:0008-5472

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    DOI: 10.1158/1538-7445.AM2014-3612

  • Extent of intranodal macrophage correlates with lymph node metastasis of gastric cancer Reviewed

    Yukie Go, Hiroaki Tanaka, Mao Tokumoto, Yoshihiro Okita, Masatsune Shibutani, Sadaaki Yamazoe, Katsunobu Sakurai, Hisashi Nagahara, Kenjiro Kimura, Takahiro Toyokawa, Ryosuke Amano, Naoshi Kubo, Kazuya Muguruma, Hiroshi Otani, Masakazu Yashiro, Kiyoshi Maeda, Masaichi Ohira, Kosei Hirakawa

    CANCER RESEARCH   74 ( 19 )   2014.10( ISSN:0008-5472

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    DOI: 10.1158/1538-7445.AM2014-1081

  • Establishment and characterization of two cell lines of anaplastic pancreatic cancer Reviewed

    Kotaro Miura, Kenjiro Kimura, Ryosuke Amano, Sadaaki Yamazoe, Keiichiro Hirata, Masatsune Shibutani, Katsunobu Sakurai, Hisashi Nagahara, Takahiro Toyokawa, Naoshi Kubo, Hiroaki Tanaka, Kazuya Muguruma, Hiroshi Otani, Masakazu Yashiro, Kiyoshi Maeda, Masaichi Ohira, Kosei Hirakawa

    CANCER RESEARCH   74 ( 19 )   2014.10( ISSN:0008-5472

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    DOI: 10.1158/1538-7445.AM2014-3924

  • The effect of PGE2 receptor inhibitor on the microenviroment of scirrhous gastric cancer Reviewed

    Tatsunari Fukuoka, Masakazu Yashiro, Hiroshi Takeda, Takayuki Maruyama, Hiroaki Kasashima, Go Masuda, Haruhito Kinoshita, Tamami Morisaki, Katsunobu Sakurai, Masatsune Shibutani, Sadaaki Yamazoe, Kenjiro Kimura, Hisashi Nagahara, Takahiro Toyokawa, Ryosuke Amano, Naoshi Kubo, Hiroaki Tanaka, Kazuya Muguruma, Hiroshi Otani, Kiyoshi Maeda, Masaichi Ohira, Kosei Hirakawa

    CANCER RESEARCH   74 ( 19 )   2014.10( ISSN:0008-5472

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    DOI: 10.1158/1538-7445.AM2014-3606

  • Prognostic Significance of the Preoperative Ratio of C-Reactive Protein to Albumin in Patients with Colorectal Cancer.

    Anticancer Res.   2014.07

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  • Prognostic Significance of the Preoperative Ratio of C-Reactive Protein to Albumin in Patients with Colorectal Cancer. Reviewed

    Anticancer Res.   2014.07

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  • Significance of CEA and CA19-9 combination as a prognostic indicator and for recurrence monitoring in patients with stage II colorectal cancer. Reviewed

    Shibutani M, Maeda K, Nagahara H, Ohtani H, Sakurai K, Toyokawa T, Kubo N, Tanaka H, Muguruma K, Ohira M, Hirakawa K

    Anticancer research   34 ( 7 )   3753 - 8   2014.07( ISSN:0250-7005

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    PubMed

  • Significance of CEA and CA19-9 Combination as a Prognostic Indicator and for Recurrence Monitoring in Patients with Stage II Colorectal Cancer Reviewed

    Shibutani Masatsune, Maeda Kiyoshi, Nagahara Hisashi, Ohtani Hiroshi, Sakurai Katsunobu, Toyokawa Takahiro, Kubo Naoshi, Tanaka Hiroaki, Muguruma Kazuya, Ohira Masaichi, Hirakawa Kosei

    ANTICANCER RESEARCH   34 ( 7 )   3753 - 3758   2014.07( ISSN:0250-7005

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  • Prognostic Significance of the Preoperative Ratio of C-Reactive Protein to Albumin in Patients with Colorectal Cancer. Reviewed

    澁谷 雅常

    Anticancer Res.   2014.07

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  • Significance of CEA and CA19-9 Combination as a Prognostic Indicator and for Recurrence Monitoring in Patients with Stage II Colorectal Cancer Reviewed

    Masatsune Shibutani, Kiyoshi Maeda, Hisashi Nagahara, Hiroshi Ohtani, Katsunobu Sakurai, Takahiro Toyokawa, Naoshi Kubo, Hiroaki Tanaka, Kazuya Muguruma, Masaichi Ohira, Kosei Hirakawa

    ANTICANCER RESEARCH   34 ( 7 )   3753 - 3758   2014.07( ISSN:0250-7005

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    Background: The purpose of this study was to evaluate the significance of the combination of the carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA19-9) levels as a prognostic indicator and for monitoring for recurrence and metastasis after potentially curative surgery for patients with stage II colorectal cancer. Patients and Methods: A total of 238 patients with stage II colorectal cancer who underwent potentially curative surgery were enrolled in the study. A high CEA level was defined as a level exceeding 5 ng/ml and a high CA19-9 level was defined as a level exceeding 37 U/ml. Results: Out of these 238 patients, 92 (38.7%) patients had high CEA levels, 23 (9.7%) patients had high CA19-9 levels and 15 (6.3%) patients had both high CEA and CA19-9 levels. The disease-free and overall survival rates were significantly worse in patients with both a high CEA level and high CA19-9 level. Tumor marker(s) elevated before the operation tended to be elevated again at the time of relapse. Conclusion: The combination of preoperative CEA and CA19-9 levels was useful for predicting the prognosis and for monitoring recurrence and metastasis after potentially curative surgery in patents with stage II colorectal cancer.

  • Significance of CEA and CA19-9 combination as a prognostic indicator and for recurrence monitoring in patients with stage II colorectal cancer.

    Shibutani M, Maeda K, Nagahara H, Ohtani H, Sakurai K, Toyokawa T, Kubo N, Tanaka H, Muguruma K, Ohira M, Hirakawa K

    Anticancer research   34 ( 7 )   3753 - 8   2014.07( ISSN:0250-7005

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  • Significance of CEA and CA19-9 combination as a prognostic indicator and for recurrence monitoring in patients with stage II colorectal cancer. Reviewed

    Shibutani M, Maeda K, Nagahara H, Ohtani H, Sakurai K, Toyokawa T, Kubo N, Tanaka H, Muguruma K, Ohira M, Hirakawa K

    Anticancer research   34 ( 7 )   3753 - 8   2014.07( ISSN:0250-7005

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    PubMed

  • Low Nutritional Prognostic Index Correlates with Poor Survival in Patients with Stage IV Colorectal Cancer Following Palliative Resection of the Primary Tumor Reviewed

    Maeda Kiyoshi, Shibutani Masatsune, Otani Hiroshi, Nagahara Hisashi, Sugano Kenji, Ikeya Teturo, Kubo Naoshi, Amano Ryosuke, Kimura Kenjiro, Muguruma Kazuya, Tanaka Hiroaki, Hirakawa Kosei

    WORLD JOURNAL OF SURGERY   38 ( 5 )   1217 - 1222   2014.05( ISSN:0364-2313

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    DOI: 10.1007/s00268-013-2386-x

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  • The impact of combined thoracoscopic and laparoscopic surgery on pulmonary complications after radical esophagectomy in patients with resectable esophageal cancer. Reviewed

    Kubo N, Ohira M, Yamashita Y, Sakurai K, Toyokawa T, Tanaka H, Muguruma K, Shibutani M, Yamazoe S, Kimura K, Nagahara H, Amano R, Ohtani H, Yashiro M, Maeda K, Hirakawa K

    Anticancer research   34 ( 5 )   2399 - 404   2014.05( ISSN:0250-7005

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  • The Impact of Combined Thoracoscopic and Laparoscopic Surgery on Pulmonary Complications After Radical Esophagectomy in Patients With Resectable Esophageal Cancer Reviewed

    Kubo Naoshi, Ohira Masaichi, Yamashita Yoshito, Sakurai Katsunobu, Toyokawa Takahiro, Tanaka Hiroaki, Muguruma Kazuya, Shibutani Masatsune, Yamazoe Sadaaki, Kimura Kenjiro, Nagahara Hisashi, Amano Ryosuke, Ohtani Hiroshi, Yashiro Masakazu, Maeda Kiyoshi, Hirakawa Kosei

    ANTICANCER RESEARCH   34 ( 5 )   2399 - 2404   2014.05( ISSN:0250-7005

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  • Low Nutritional Prognostic Index Correlates with Poor Survival in Patients with Stage IV Colorectal Cancer Following Palliative Resection of the Primary Tumor Reviewed

    Kiyoshi Maeda, Masatsune Shibutani, Hiroshi Otani, Hisashi Nagahara, Kenji Sugano, Teturo Ikeya, Naoshi Kubo, Ryosuke Amano, Kenjiro Kimura, Kazuya Muguruma, Hiroaki Tanaka, Kosei Hirakawa

    WORLD JOURNAL OF SURGERY   38 ( 5 )   1217 - 22   2014.05( ISSN:0364-2313

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    We retrospectively investigated the prognostic significance of various clinicopathological factors and preoperative nutritional status to select patients with stage IV colorectal cancer (CRC) who will have a poor prognosis after palliative resection of the primary tumor.
    A total of 100 stage IV CRC patients who underwent palliative resection were enrolled. Various clinicopathological factors and Onodera's prognostic nutritional index (OPNI) were evaluated to identify any possible relationship with the prognosis.
    At the time of the analysis, 83 patients had died, and the median survival time was 21 months. Of the 100 patients, 24 had primary tumor-related symptoms such as obstruction or bleeding. No significant correlation was noted between the OPNI and various clinicopathological factors. The multivariate analysis of patients without primary tumor-related symptoms revealed that the OPNI was an independent prognostic factor. The overall survival of the low-OPNI group was significantly worse than that of the high-OPNI group.
    This retrospective study suggested that patients with a low OPNI may not be candidates for palliative resection, because it provides no survival benefit to these patients.

    DOI: 10.1007/s00268-013-2386-x

    PubMed

  • The Impact of Combined Thoracoscopic and Laparoscopic Surgery on Pulmonary Complications After Radical Esophagectomy in Patients With Resectable Esophageal Cancer Reviewed

    Naoshi Kubo, Masaichi Ohira, Yoshito Yamashita, Katsunobu Sakurai, Takahiro Toyokawa, Hiroaki Tanaka, Kazuya Muguruma, Masatsune Shibutani, Sadaaki Yamazoe, Kenjiro Kimura, Hisashi Nagahara, Ryosuke Amano, Hiroshi Ohtani, Masakazu Yashiro, Kiyoshi Maeda, Kosei Hirakawa

    ANTICANCER RESEARCH   34 ( 5 )   2399 - 2404   2014.05( ISSN:0250-7005

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    Background: Pulmonary complications (PCs) after esophagectomy for patients with esophageal cancer have been correlated with prolonged hospital stays and in-hospital mortality. Previous studies have shown that minimally-invasive esophagectomy (MIE) is associated with a lower rate of PCs compared to conventional open surgery. Although PCs were reportedly associated with many factors, including surgical approaches, patients' demographics, and perioperative variables, the predictive factors for PCs including MIE, have not been fully evaluated. Patients and Methods: A total of 209 patients with resectable esophageal cancer who underwent three types of esophagectomy were included in the present study; (i) 93 cases who underwent the combined thoracoscopic MIE and laparoscopic MIE; (ii) 42 cases who underwent the combined open thoracotomy and laparoscopic MIE; (iii) 74 cases who underwent the combined open thoracotomy and open laparotomy, which were defined as the total MIE group, hybrid MIE group, and total open group, respectively. We compared clinical outcomes of the three groups and identified postoperative predictive factors of PCs using multivariate analysis. Results: The incidence of PCs was significantly reduced (p=0.015) in the total-MIE group (8193: 8.5%) compared with the total-open group (16/74: 21.6%), but it was not significantly reduced in the hybrid MIE group (5142: 11.9%) compared with the total open group (p=0.19). The multivariate analysis showed that the presence of cardiac comorbidity [odds ratio (OR)=5.90; p=0.013], lung comorbidity (OR=3.95; p=0.031), and anastomotic leakage (OR=6.00; p&lt;0.01) were independent risk factors for PCs after esophagectomy. In contrast, total MIE reduced the risk of PCs (OR=0.328; p=0.036). Conclusion: The combination of thoracoscopic and laparoscopic MIE presents as an excellent surgical procedure for the reduction of PCs after esophagectomy.

  • The impact of combined thoracoscopic and laparoscopic surgery on pulmonary complications after radical esophagectomy in patients with resectable esophageal cancer.

    Kubo N, Ohira M, Yamashita Y, Sakurai K, Toyokawa T, Tanaka H, Muguruma K, Shibutani M, Yamazoe S, Kimura K, Nagahara H, Amano R, Ohtani H, Yashiro M, Maeda K, Hirakawa K

    Anticancer research   34 ( 5 )   2399 - 404   2014.05( ISSN:0250-7005

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  • The impact of combined thoracoscopic and laparoscopic surgery on pulmonary complications after radical esophagectomy in patients with resectable esophageal cancer. Reviewed

    Kubo N, Ohira M, Yamashita Y, Sakurai K, Toyokawa T, Tanaka H, Muguruma K, Shibutani M, Yamazoe S, Kimura K, Nagahara H, Amano R, Ohtani H, Yashiro M, Maeda K, Hirakawa K

    Anticancer research   34 ( 5 )   2399 - 404   2014.05( ISSN:0250-7005

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  • OP-007-7 膵切除後耐糖能悪化の危険因子に関する検討(OP-007 膵 合併症-2,一般演題,第114回日本外科学会定期学術集会) Reviewed

    平田 啓一郎, 天野 良亮, 木村 健二郎, 山添 定明, 永原 央, 桜井 克宜, 渋谷 雅常, 豊川 貴弘, 久保 尚士, 田中 浩明, 六車 一哉, 大谷 博, 前田 清, 大平 雅一, 平川 弘聖

    一般社団法人日本外科学会 日本外科学会雑誌   115 ( 2 )   2014.03( ISSN:18801129

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  • PS-216-2 進行胃癌に対するMDCTを用いた術前リンパ節転移診断(PS-216 胃 手術適応-2,ポスターセッション,第114回日本外科学会定期学術集会) Reviewed

    豊川 貴弘, 六車 一哉, 田中 浩明, 渋谷 雅常, 山添 定明, 櫻井 克宣, 永原 央, 木村 健二郎, 天野 良亮, 久保 尚士, 山本 篤, 大谷 博, 山下 好人, 前田 清, 澤田 鉄二, 大平 雅一, 平川 弘聖

    一般社団法人日本外科学会 日本外科学会雑誌   115 ( 2 )   2014.03( ISSN:18801129

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  • PS-210-7 併存疾患を有する胃癌患者に対する鏡視下手術の周術期成績(PS-210 胃 高齢者-2・その他,ポスターセッション,第114回日本外科学会定期学術集会) Reviewed

    櫻井 克宣, 六車 一哉, 石原 沙江, 西尾 康平, 田村 達郎, 平田 啓一郎, 渋谷 雅常, 山添 定明, 木村 健二郎, 永原 央, 豊川 貴弘, 天野 良亮, 久保 尚士, 田中 浩明, 大谷 博, 八代 正和, 山下 好人, 前田 清, 澤田 鉄二, 大平 雅一, 平川 弘聖

    一般社団法人日本外科学会 日本外科学会雑誌   115 ( 2 )   2014.03( ISSN:18801129

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  • PS-207-3 胸部食道癌に対する腹臥位胸腔鏡下食道切除術の有用性(PS-207 食道 鏡視下手術-1,ポスターセッション,第114回日本外科学会定期学術集会) Reviewed

    久保 尚士, 大平 雅一, 櫻井 克宣, 豊川 貴弘, 田中 浩明, 六車 一哉, 渋谷 雅常, 山添 定明, 永原 央, 木村 健二郎, 天野 良亮, 山下 好人, 八代 正和, 前田 清, 平川 弘聖

    一般社団法人日本外科学会 日本外科学会雑誌   115 ( 2 )   2014.03( ISSN:18801129

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  • PS-185-7 十二指腸GISTの臨床病理学的検討(PS-185 消化管 GIST,ポスターセッション,第114回日本外科学会定期学術集会) Reviewed

    田村 達郎, 豊川 貴弘, 六車 一哉, 渋谷 雅常, 山添 定明, 櫻井 克宣, 永原 央, 木村 健二郎, 天野 良亮, 久保 尚士, 田中 浩明, 大谷 博, 山下 好人, 前田 清, 澤田 鉄二, 大平 雅一, 平川 弘聖

    一般社団法人日本外科学会 日本外科学会雑誌   115 ( 2 )   2014.03( ISSN:18801129

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  • PS-178-2 胃癌所属リンパ節内ヘルパーT細胞分画と転移の影響(PS-178 基礎 腫瘍免疫,ポスターセッション,第114回日本外科学会定期学術集会) Reviewed

    大北 仁裕, 田中 浩明, 呉 幸枝, 渡邊 真央, 澁谷 雅常, 櫻井 克宜, 山添 定明, 木村 健二郎, 永原 央, 豊川 貴弘, 天野 良亮, 久保 尚士, 六車 一哉, 大谷 博, 前田 清, 澤田 鉄二, 大平 雅一, 平川 弘聖

    一般社団法人日本外科学会 日本外科学会雑誌   115 ( 2 )   2014.03( ISSN:18801129

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  • PS-178-1 胃癌の所属リンパ節内浸潤好中球とリンパ管新生との関連(PS-178 基礎 腫瘍免疫,ポスターセッション,第114回日本外科学会定期学術集会) Reviewed

    渡邊 真央, 田中 浩明, 呉 幸枝, 大北 仁裕, 渋谷 雅常, 櫻井 克宣, 山添 定明, 永原 央, 木村 健二郎, 豊川 貴弘, 天野 良亮, 六車 一哉, 大谷 博, 前田 清, 澤田 鉄二, 大平 雅一, 平川 弘聖

    一般社団法人日本外科学会 日本外科学会雑誌   115 ( 2 )   2014.03( ISSN:18801129

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  • PS-114-5 大腸癌における再発予測因子としてのxCT発現の検討(PS-114 大腸 基礎-2,ポスターセッション,第114回日本外科学会定期学術集会) Reviewed

    菅野 兼史, 前田 清, 大谷 博, 永原 央, 渋谷 雅常, 池谷 哲郎, 櫻井 克宣, 山添 定明, 野田 諭, 木村 健二郎, 川尻 成美, 豊川 貴弘, 天野 良亮, 久保 尚士, 田中 浩明, 六車 一哉, 高島 勉, 小野田 尚佳, 大平 雅一, 平川 弘聖

    一般社団法人日本外科学会 日本外科学会雑誌   115 ( 2 )   2014.03( ISSN:18801129

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  • PS-086-2 当科におけるincidental gallbladder carcinomaの治療成績(PS-086 胆 悪性-5,ポスターセッション,第114回日本外科学会定期学術集会) Reviewed

    山添 定明, 天野 良亮, 木村 健二郎, 平田 啓一郎, 渋谷 雅常, 櫻井 克宣, 永原 央, 豊川 貴弘, 久保 尚士, 田中 浩明, 六車 一哉, 大谷 博, 前田 清, 澤田 鉄二, 仲田 文造, 大平 雅一, 平川 弘聖

    一般社団法人日本外科学会 日本外科学会雑誌   115 ( 2 )   2014.03( ISSN:18801129

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  • PS-053-3 胃癌に対する腹腔鏡下胃全摘術後の食道空腸吻合術の変遷と工夫(PS-053 胃 手術手技-1,ポスターセッション,第114回日本外科学会定期学術集会) Reviewed

    六車 一哉, 田中 浩明, 櫻井 克宣, 豊川 貴弘, 渋谷 雅常, 山添 定明, 木村 健二郎, 永原 央, 天野 良亮, 久保 尚士, 大谷 博, 山本 篤, 山下 好人, 前田 清, 澤田 鉄二, 大平 雅一, 平川 弘聖

    一般社団法人日本外科学会 日本外科学会雑誌   115 ( 2 )   2014.03( ISSN:18801129

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  • PS-016-3 当科において経験した膵神経内分泌腫瘍33例の治療成績(PS-016 膵 腫瘍 NET-2,ポスターセッション,第114回日本外科学会定期学術集会) Reviewed

    木村 健二郎, 天野 良亮, 山添 定明, 平田 啓一郎, 櫻井 克亘, 渋谷 雅常, 永原 央, 豊川 貴弘, 久保 尚士, 田中 浩明, 六車 一哉, 大谷 博, 前田 清, 仲田 文造, 大平 雅一, 平川 弘聖

    一般社団法人日本外科学会 日本外科学会雑誌   115 ( 2 )   2014.03( ISSN:18801129

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  • PD-11-7 クローン病術前抗TNF-α抗体薬治療症例における周術期合併症の検討(PD-11 パネルディスカッション(11)薬物療法の進歩に応じた炎症性腸疾患の外科治療,第114回日本外科学会定期学術集会) Reviewed

    前田 清, 永原 央, 大谷 博, 渋谷 雅常, 菅野 兼史, 池谷 哲郎, 天野 良亮, 六車 一哉, 田中 浩明, 木村 健二郎, 平川 弘聖

    一般社団法人日本外科学会 日本外科学会雑誌   115 ( 2 )   2014.03( ISSN:18801129

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  • OP-126-4 StageII/III胃癌における根治切除後再発と術後好中球リンパ球比との関係(OP-126 胃 集学的治療,一般演題,第114回日本外科学会定期学術集会) Reviewed

    田中 浩明, 六車 一哉, 櫻井 克宜, 豊川 貴弘, 久保 尚士, 山添 定明, 渋谷 雅常, 永原 央, 木村 健二郎, 天野 良亮, 大谷 博, 山本 篤, 山下 好人, 前田 清, 澤田 鉄二, 大平 雅一, 平川 弘聖

    一般社団法人日本外科学会 日本外科学会雑誌   115 ( 2 )   2014.03( ISSN:18801129

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  • OP-048-1 大腸癌における術前CEA・CA19-9値の意義(OP-048 大腸 その他,一般演題,第114回日本外科学会定期学術集会) Reviewed

    渋谷 雅常, 前田 清, 永原 央, 大谷 博, 池谷 哲郎, 菅野 兼史, 櫻井 克宜, 山添 定明, 木村 健二郎, 天野 良亮, 久保 尚士, 田中 浩明, 六車 一哉, 大平 雅一, 平川 弘聖

    一般社団法人日本外科学会 日本外科学会雑誌   115 ( 2 )   2014.03( ISSN:18801129

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    CiNii Article

  • OP-045-5 予後因子からみたStageIV大腸癌に対する治療戦略(OP-045 大腸 大腸癌 stageIV,一般演題,第114回日本外科学会定期学術集会) Reviewed

    大谷 博, 前田 清, 永原 央, 渋谷 雅常, 大平 雅一, 六車 一哉, 田中 浩明, 久保 尚士, 豊川 貴弘, 櫻井 克宣, 天野 良亮, 木村 健二郎, 山添 定明, 平川 弘聖

    一般社団法人日本外科学会 日本外科学会雑誌   115 ( 2 )   2014.03( ISSN:18801129

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  • OP-007-7 膵切除後耐糖能悪化の危険因子に関する検討(OP-007 膵 合併症-2,一般演題,第114回日本外科学会定期学術集会) Reviewed

    平田 啓一郎, 天野 良亮, 木村 健二郎, 山添 定明, 永原 央, 桜井 克宜, 渋谷 雅常, 豊川 貴弘, 久保 尚士, 田中 浩明, 六車 一哉, 大谷 博, 前田 清, 大平 雅一, 平川 弘聖

    一般社団法人日本外科学会 日本外科学会雑誌   115 ( 2 )   2014.03( ISSN:1880-1129

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  • PD-11-7 クローン病術前抗TNF-α抗体薬治療症例における周術期合併症の検討(PD-11 パネルディスカッション(11)薬物療法の進歩に応じた炎症性腸疾患の外科治療,第114回日本外科学会定期学術集会)

    前田 清, 永原 央, 大谷 博, 渋谷 雅常, 菅野 兼史, 池谷 哲郎, 天野 良亮, 六車 一哉, 田中 浩明, 木村 健二郎, 平川 弘聖

    日本外科学会雑誌   115 ( 2 )   196   2014.03( ISSN:18801129

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  • PD-11-7 クローン病術前抗TNF-α抗体薬治療症例における周術期合併症の検討(PD-11 パネルディスカッション(11)薬物療法の進歩に応じた炎症性腸疾患の外科治療,第114回日本外科学会定期学術集会) Reviewed

    前田 清, 永原 央, 大谷 博, 渋谷 雅常, 菅野 兼史, 池谷 哲郎, 天野 良亮, 六車 一哉, 田中 浩明, 木村 健二郎, 平川 弘聖

    一般社団法人日本外科学会 日本外科学会雑誌   115 ( 2 )   2014.03( ISSN:1880-1129

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  • OP-126-4 StageII/III胃癌における根治切除後再発と術後好中球リンパ球比との関係(OP-126 胃 集学的治療,一般演題,第114回日本外科学会定期学術集会)

    田中 浩明, 六車 一哉, 櫻井 克宜, 豊川 貴弘, 久保 尚士, 山添 定明, 渋谷 雅常, 永原 央, 木村 健二郎, 天野 良亮, 大谷 博, 山本 篤, 山下 好人, 前田 清, 澤田 鉄二, 大平 雅一, 平川 弘聖

    日本外科学会雑誌   115 ( 2 )   537   2014.03( ISSN:18801129

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  • OP-126-4 StageII/III胃癌における根治切除後再発と術後好中球リンパ球比との関係(OP-126 胃 集学的治療,一般演題,第114回日本外科学会定期学術集会) Reviewed

    田中 浩明, 六車 一哉, 櫻井 克宜, 豊川 貴弘, 久保 尚士, 山添 定明, 渋谷 雅常, 永原 央, 木村 健二郎, 天野 良亮, 大谷 博, 山本 篤, 山下 好人, 前田 清, 澤田 鉄二, 大平 雅一, 平川 弘聖

    一般社団法人日本外科学会 日本外科学会雑誌   115 ( 2 )   2014.03( ISSN:1880-1129

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  • OP-048-1 大腸癌における術前CEA・CA19-9値の意義(OP-048 大腸 その他,一般演題,第114回日本外科学会定期学術集会)

    渋谷 雅常, 前田 清, 永原 央, 大谷 博, 池谷 哲郎, 菅野 兼史, 櫻井 克宜, 山添 定明, 木村 健二郎, 天野 良亮, 久保 尚士, 田中 浩明, 六車 一哉, 大平 雅一, 平川 弘聖

    日本外科学会雑誌   115 ( 2 )   400   2014.03( ISSN:18801129

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  • OP-048-1 大腸癌における術前CEA・CA19-9値の意義(OP-048 大腸 その他,一般演題,第114回日本外科学会定期学術集会) Reviewed

    渋谷 雅常, 前田 清, 永原 央, 大谷 博, 池谷 哲郎, 菅野 兼史, 櫻井 克宜, 山添 定明, 木村 健二郎, 天野 良亮, 久保 尚士, 田中 浩明, 六車 一哉, 大平 雅一, 平川 弘聖

    一般社団法人日本外科学会 日本外科学会雑誌   115 ( 2 )   2014.03( ISSN:1880-1129

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  • OP-045-5 予後因子からみたStageIV大腸癌に対する治療戦略(OP-045 大腸 大腸癌 stageIV,一般演題,第114回日本外科学会定期学術集会)

    大谷 博, 前田 清, 永原 央, 渋谷 雅常, 大平 雅一, 六車 一哉, 田中 浩明, 久保 尚士, 豊川 貴弘, 櫻井 克宣, 天野 良亮, 木村 健二郎, 山添 定明, 平川 弘聖

    日本外科学会雑誌   115 ( 2 )   395   2014.03( ISSN:18801129

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  • OP-045-5 予後因子からみたStageIV大腸癌に対する治療戦略(OP-045 大腸 大腸癌 stageIV,一般演題,第114回日本外科学会定期学術集会) Reviewed

    大谷 博, 前田 清, 永原 央, 渋谷 雅常, 大平 雅一, 六車 一哉, 田中 浩明, 久保 尚士, 豊川 貴弘, 櫻井 克宣, 天野 良亮, 木村 健二郎, 山添 定明, 平川 弘聖

    一般社団法人日本外科学会 日本外科学会雑誌   115 ( 2 )   2014.03( ISSN:1880-1129

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  • OP-007-7 膵切除後耐糖能悪化の危険因子に関する検討(OP-007 膵 合併症-2,一般演題,第114回日本外科学会定期学術集会)

    平田 啓一郎, 天野 良亮, 木村 健二郎, 山添 定明, 永原 央, 桜井 克宜, 渋谷 雅常, 豊川 貴弘, 久保 尚士, 田中 浩明, 六車 一哉, 大谷 博, 前田 清, 大平 雅一, 平川 弘聖

    日本外科学会雑誌   115 ( 2 )   324   2014.03( ISSN:18801129

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  • PS-016-3 当科において経験した膵神経内分泌腫瘍33例の治療成績(PS-016 膵 腫瘍 NET-2,ポスターセッション,第114回日本外科学会定期学術集会) Reviewed

    木村 健二郎, 天野 良亮, 山添 定明, 平田 啓一郎, 櫻井 克亘, 渋谷 雅常, 永原 央, 豊川 貴弘, 久保 尚士, 田中 浩明, 六車 一哉, 大谷 博, 前田 清, 仲田 文造, 大平 雅一, 平川 弘聖

    一般社団法人日本外科学会 日本外科学会雑誌   115 ( 2 )   2014.03( ISSN:1880-1129

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  • PS-216-2 進行胃癌に対するMDCTを用いた術前リンパ節転移診断(PS-216 胃 手術適応-2,ポスターセッション,第114回日本外科学会定期学術集会)

    豊川 貴弘, 六車 一哉, 田中 浩明, 渋谷 雅常, 山添 定明, 櫻井 克宣, 永原 央, 木村 健二郎, 天野 良亮, 久保 尚士, 山本 篤, 大谷 博, 山下 好人, 前田 清, 澤田 鉄二, 大平 雅一, 平川 弘聖

    日本外科学会雑誌   115 ( 2 )   1006   2014.03( ISSN:18801129

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  • PS-216-2 進行胃癌に対するMDCTを用いた術前リンパ節転移診断(PS-216 胃 手術適応-2,ポスターセッション,第114回日本外科学会定期学術集会) Reviewed

    豊川 貴弘, 六車 一哉, 田中 浩明, 渋谷 雅常, 山添 定明, 櫻井 克宣, 永原 央, 木村 健二郎, 天野 良亮, 久保 尚士, 山本 篤, 大谷 博, 山下 好人, 前田 清, 澤田 鉄二, 大平 雅一, 平川 弘聖

    一般社団法人日本外科学会 日本外科学会雑誌   115 ( 2 )   2014.03( ISSN:1880-1129

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  • PS-210-7 併存疾患を有する胃癌患者に対する鏡視下手術の周術期成績(PS-210 胃 高齢者-2・その他,ポスターセッション,第114回日本外科学会定期学術集会)

    櫻井 克宣, 六車 一哉, 石原 沙江, 西尾 康平, 田村 達郎, 平田 啓一郎, 渋谷 雅常, 山添 定明, 木村 健二郎, 永原 央, 豊川 貴弘, 天野 良亮, 久保 尚士, 田中 浩明, 大谷 博, 八代 正和, 山下 好人, 前田 清, 澤田 鉄二, 大平 雅一, 平川 弘聖

    日本外科学会雑誌   115 ( 2 )   995   2014.03( ISSN:18801129

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  • PS-210-7 併存疾患を有する胃癌患者に対する鏡視下手術の周術期成績(PS-210 胃 高齢者-2・その他,ポスターセッション,第114回日本外科学会定期学術集会) Reviewed

    櫻井 克宣, 六車 一哉, 石原 沙江, 西尾 康平, 田村 達郎, 平田 啓一郎, 渋谷 雅常, 山添 定明, 木村 健二郎, 永原 央, 豊川 貴弘, 天野 良亮, 久保 尚士, 田中 浩明, 大谷 博, 八代 正和, 山下 好人, 前田 清, 澤田 鉄二, 大平 雅一, 平川 弘聖

    一般社団法人日本外科学会 日本外科学会雑誌   115 ( 2 )   2014.03( ISSN:1880-1129

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  • PS-207-3 胸部食道癌に対する腹臥位胸腔鏡下食道切除術の有用性(PS-207 食道 鏡視下手術-1,ポスターセッション,第114回日本外科学会定期学術集会)

    久保 尚士, 大平 雅一, 櫻井 克宣, 豊川 貴弘, 田中 浩明, 六車 一哉, 渋谷 雅常, 山添 定明, 永原 央, 木村 健二郎, 天野 良亮, 山下 好人, 八代 正和, 前田 清, 平川 弘聖

    日本外科学会雑誌   115 ( 2 )   988   2014.03( ISSN:18801129

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  • PS-207-3 胸部食道癌に対する腹臥位胸腔鏡下食道切除術の有用性(PS-207 食道 鏡視下手術-1,ポスターセッション,第114回日本外科学会定期学術集会) Reviewed

    久保 尚士, 大平 雅一, 櫻井 克宣, 豊川 貴弘, 田中 浩明, 六車 一哉, 渋谷 雅常, 山添 定明, 永原 央, 木村 健二郎, 天野 良亮, 山下 好人, 八代 正和, 前田 清, 平川 弘聖

    一般社団法人日本外科学会 日本外科学会雑誌   115 ( 2 )   2014.03( ISSN:1880-1129

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  • PS-185-7 十二指腸GISTの臨床病理学的検討(PS-185 消化管 GIST,ポスターセッション,第114回日本外科学会定期学術集会)

    田村 達郎, 豊川 貴弘, 六車 一哉, 渋谷 雅常, 山添 定明, 櫻井 克宣, 永原 央, 木村 健二郎, 天野 良亮, 久保 尚士, 田中 浩明, 大谷 博, 山下 好人, 前田 清, 澤田 鉄二, 大平 雅一, 平川 弘聖

    日本外科学会雑誌   115 ( 2 )   945   2014.03( ISSN:18801129

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  • PS-185-7 十二指腸GISTの臨床病理学的検討(PS-185 消化管 GIST,ポスターセッション,第114回日本外科学会定期学術集会) Reviewed

    田村 達郎, 豊川 貴弘, 六車 一哉, 渋谷 雅常, 山添 定明, 櫻井 克宣, 永原 央, 木村 健二郎, 天野 良亮, 久保 尚士, 田中 浩明, 大谷 博, 山下 好人, 前田 清, 澤田 鉄二, 大平 雅一, 平川 弘聖

    一般社団法人日本外科学会 日本外科学会雑誌   115 ( 2 )   2014.03( ISSN:1880-1129

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  • PS-178-2 胃癌所属リンパ節内ヘルパーT細胞分画と転移の影響(PS-178 基礎 腫瘍免疫,ポスターセッション,第114回日本外科学会定期学術集会) Reviewed

    大北 仁裕, 田中 浩明, 呉 幸枝, 渡邊 真央, 澁谷 雅常, 櫻井 克宜, 山添 定明, 木村 健二郎, 永原 央, 豊川 貴弘, 天野 良亮, 久保 尚士, 六車 一哉, 大谷 博, 前田 清, 澤田 鉄二, 大平 雅一, 平川 弘聖

    一般社団法人日本外科学会 日本外科学会雑誌   115 ( 2 )   2014.03( ISSN:1880-1129

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  • PS-178-1 胃癌の所属リンパ節内浸潤好中球とリンパ管新生との関連(PS-178 基礎 腫瘍免疫,ポスターセッション,第114回日本外科学会定期学術集会)

    渡邊 真央, 田中 浩明, 呉 幸枝, 大北 仁裕, 渋谷 雅常, 櫻井 克宣, 山添 定明, 永原 央, 木村 健二郎, 豊川 貴弘, 天野 良亮, 六車 一哉, 大谷 博, 前田 清, 澤田 鉄二, 大平 雅一, 平川 弘聖

    日本外科学会雑誌   115 ( 2 )   930   2014.03( ISSN:18801129

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  • PS-178-1 胃癌の所属リンパ節内浸潤好中球とリンパ管新生との関連(PS-178 基礎 腫瘍免疫,ポスターセッション,第114回日本外科学会定期学術集会) Reviewed

    渡邊 真央, 田中 浩明, 呉 幸枝, 大北 仁裕, 渋谷 雅常, 櫻井 克宣, 山添 定明, 永原 央, 木村 健二郎, 豊川 貴弘, 天野 良亮, 六車 一哉, 大谷 博, 前田 清, 澤田 鉄二, 大平 雅一, 平川 弘聖

    一般社団法人日本外科学会 日本外科学会雑誌   115 ( 2 )   2014.03( ISSN:1880-1129

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  • PS-114-5 大腸癌における再発予測因子としてのxCT発現の検討(PS-114 大腸 基礎-2,ポスターセッション,第114回日本外科学会定期学術集会)

    菅野 兼史, 前田 清, 大谷 博, 永原 央, 渋谷 雅常, 池谷 哲郎, 櫻井 克宣, 山添 定明, 野田 諭, 木村 健二郎, 川尻 成美, 豊川 貴弘, 天野 良亮, 久保 尚士, 田中 浩明, 六車 一哉, 高島 勉, 小野田 尚佳, 大平 雅一, 平川 弘聖

    日本外科学会雑誌   115 ( 2 )   803   2014.03( ISSN:18801129

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  • PS-114-5 大腸癌における再発予測因子としてのxCT発現の検討(PS-114 大腸 基礎-2,ポスターセッション,第114回日本外科学会定期学術集会) Reviewed

    菅野 兼史, 前田 清, 大谷 博, 永原 央, 渋谷 雅常, 池谷 哲郎, 櫻井 克宣, 山添 定明, 野田 諭, 木村 健二郎, 川尻 成美, 豊川 貴弘, 天野 良亮, 久保 尚士, 田中 浩明, 六車 一哉, 高島 勉, 小野田 尚佳, 大平 雅一, 平川 弘聖

    一般社団法人日本外科学会 日本外科学会雑誌   115 ( 2 )   2014.03( ISSN:1880-1129

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  • PS-086-2 当科におけるincidental gallbladder carcinomaの治療成績(PS-086 胆 悪性-5,ポスターセッション,第114回日本外科学会定期学術集会)

    山添 定明, 天野 良亮, 木村 健二郎, 平田 啓一郎, 渋谷 雅常, 櫻井 克宣, 永原 央, 豊川 貴弘, 久保 尚士, 田中 浩明, 六車 一哉, 大谷 博, 前田 清, 澤田 鉄二, 仲田 文造, 大平 雅一, 平川 弘聖

    日本外科学会雑誌   115 ( 2 )   746   2014.03( ISSN:18801129

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  • PS-086-2 当科におけるincidental gallbladder carcinomaの治療成績(PS-086 胆 悪性-5,ポスターセッション,第114回日本外科学会定期学術集会) Reviewed

    山添 定明, 天野 良亮, 木村 健二郎, 平田 啓一郎, 渋谷 雅常, 櫻井 克宣, 永原 央, 豊川 貴弘, 久保 尚士, 田中 浩明, 六車 一哉, 大谷 博, 前田 清, 澤田 鉄二, 仲田 文造, 大平 雅一, 平川 弘聖

    一般社団法人日本外科学会 日本外科学会雑誌   115 ( 2 )   2014.03( ISSN:1880-1129

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    CiNii Article

  • PS-053-3 胃癌に対する腹腔鏡下胃全摘術後の食道空腸吻合術の変遷と工夫(PS-053 胃 手術手技-1,ポスターセッション,第114回日本外科学会定期学術集会)

    六車 一哉, 田中 浩明, 櫻井 克宣, 豊川 貴弘, 渋谷 雅常, 山添 定明, 木村 健二郎, 永原 央, 天野 良亮, 久保 尚士, 大谷 博, 山本 篤, 山下 好人, 前田 清, 澤田 鉄二, 大平 雅一, 平川 弘聖

    日本外科学会雑誌   115 ( 2 )   680   2014.03( ISSN:18801129

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  • PS-053-3 胃癌に対する腹腔鏡下胃全摘術後の食道空腸吻合術の変遷と工夫(PS-053 胃 手術手技-1,ポスターセッション,第114回日本外科学会定期学術集会) Reviewed

    六車 一哉, 田中 浩明, 櫻井 克宣, 豊川 貴弘, 渋谷 雅常, 山添 定明, 木村 健二郎, 永原 央, 天野 良亮, 久保 尚士, 大谷 博, 山本 篤, 山下 好人, 前田 清, 澤田 鉄二, 大平 雅一, 平川 弘聖

    一般社団法人日本外科学会 日本外科学会雑誌   115 ( 2 )   2014.03( ISSN:1880-1129

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    CiNii Article

  • PS-016-3 当科において経験した膵神経内分泌腫瘍33例の治療成績(PS-016 膵 腫瘍 NET-2,ポスターセッション,第114回日本外科学会定期学術集会)

    木村 健二郎, 天野 良亮, 山添 定明, 平田 啓一郎, 櫻井 克亘, 渋谷 雅常, 永原 央, 豊川 貴弘, 久保 尚士, 田中 浩明, 六車 一哉, 大谷 博, 前田 清, 仲田 文造, 大平 雅一, 平川 弘聖

    日本外科学会雑誌   115 ( 2 )   606   2014.03( ISSN:18801129

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  • Successful Resection of Esophageal Carcinoma with Aberrant Right Subclavian Artery Using Video-assisted Thoracoscopic Surgery: Report of Two Cases Reviewed

    Kasashima Hiroaki, Kubo Naoshi, Ohira Masaichi, Sakurai Katsunobu, Toyokawa Takahiro, Tanaka Hiroaki, Muguruma Kazuya, Shibutani Masatsune, Yamazoe Sadaaki, Keviura Kenjiro, Nagahara Hisashi, Amano Ryosuke, Ohtani Hiroshi, Yashiro Masakazu, Maeda Kiyoshi, Hirakawa Kosei

    ANTICANCER RESEARCH   34 ( 2 )   899 - 904   2014.02( ISSN:0250-7005

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  • Successful resection of esophageal carcinoma with aberrant right subclavian artery using video-assisted thoracoscopic surgery: report of two cases. Reviewed

    Kasashima H, Kubo N, Ohira M, Sakurai K, Toyokawa T, Tanaka H, Muguruma K, Shibutani M, Yamazoe S, Kimura K, Nagahara H, Amano R, Ohtani H, Yashiro M, Maeda K, Hirakawa K

    Anticancer research   34 ( 2 )   899 - 904   2014.02( ISSN:0250-7005

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    PubMed

  • Successful Resection of Esophageal Carcinoma with Aberrant Right Subclavian Artery Using Video-assisted Thoracoscopic Surgery: Report of Two Cases Reviewed

    Hiroaki Kasashima, Naoshi Kubo, Masaichi Ohira, Katsunobu Sakurai, Takahiro Toyokawa, Hiroaki Tanaka, Kazuya Muguruma, Masatsune Shibutani, Sadaaki Yamazoe, Kenjiro Keviura, Hisashi Nagahara, Ryosuke Amano, Hiroshi Ohtani, Masakazu Yashiro, Kiyoshi Maeda, Kosei Hirakawa

    ANTICANCER RESEARCH   34 ( 2 )   899 - 904   2014.02( ISSN:0250-7005

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    The right non-recurrent inferior laryngeal nerve (NRILN) is a rare nerve anomaly that communicates the laryngeal nerve to the right vagal nerve trunk directly in the neck, which is usually accompanied by aberrant right subclavian artery (ARSA). We report on two cases of thoracic esophageal carcinoma undertaken in patients with these abnormalities: a 73-year-old woman with progressive dysphagia and a 63-year-old asymptomatic man. Although there have been 10 cases of thoracic esophageal carcinomas associated with ARSA and NRILN in literature, as far as we are aware of, this is the first report to describe successful resection using video-assisted thoracoscopic surgery (VATS). We found that the combination of preoperative recognition of the ARSA using three-dimensional computed tomography (3D-CT) and VATS in the prone position allowed for visual magnification with an excellent thoracoscopic view and facilitated successful tumor resection and preservation of NRILN.

  • Successful resection of esophageal carcinoma with aberrant right subclavian artery using video-assisted thoracoscopic surgery: report of two cases.

    Kasashima H, Kubo N, Ohira M, Sakurai K, Toyokawa T, Tanaka H, Muguruma K, Shibutani M, Yamazoe S, Kimura K, Nagahara H, Amano R, Ohtani H, Yashiro M, Maeda K, Hirakawa K

    Anticancer research   34 ( 2 )   899 - 904   2014.02( ISSN:0250-7005

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  • Successful Resection of Esophageal Carcinoma with Aberrant Right Subclavian Artery Using Video-assisted Thoracoscopic Surgery: Report of Two Cases Reviewed

    Hiroaki Kasashima, Naoshi Kubo, Masaichi Ohira, Katsunobu Sakurai, Takahiro Toyokawa, Hiroaki Tanaka, Kazuya Muguruma, Masatsune Shibutani, Sadaaki Yamazoe, Kenjiro Keviura, Hisashi Nagahara, Ryosuke Amano, Hiroshi Ohtani, Masakazu Yashiro, Kiyoshi Maeda, Kosei Hirakawa

    ANTICANCER RESEARCH   34 ( 2 )   899 - 904   2014.02( ISSN:0250-7005

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    Publishing type:Research paper (scientific journal)  

    The right non-recurrent inferior laryngeal nerve (NRILN) is a rare nerve anomaly that communicates the laryngeal nerve to the right vagal nerve trunk directly in the neck, which is usually accompanied by aberrant right subclavian artery (ARSA). We report on two cases of thoracic esophageal carcinoma undertaken in patients with these abnormalities: a 73-year-old woman with progressive dysphagia and a 63-year-old asymptomatic man. Although there have been 10 cases of thoracic esophageal carcinomas associated with ARSA and NRILN in literature, as far as we are aware of, this is the first report to describe successful resection using video-assisted thoracoscopic surgery (VATS). We found that the combination of preoperative recognition of the ARSA using three-dimensional computed tomography (3D-CT) and VATS in the prone position allowed for visual magnification with an excellent thoracoscopic view and facilitated successful tumor resection and preservation of NRILN.

    PubMed

  • Elevated Preoperative Serum C-Reactive Protein Levels are Associated with Poor Survival in Patients with Colorectal Cancer Reviewed

    Shibutani Masatsune, Maeda Kiyoshi, Nagahara Hisashi, Ohtani Hiroshi, Sugano Kenji, Ikeya Tetsuro, Kimura Kenjiro, Amano Ryosuke, Kubo Naoshi, Tanaka Hiroaki, Muguruma Kazuya, Ohira Masaichi, Hirakawa Kosei

    HEPATO-GASTROENTEROLOGY   61 ( 136 )   2236 - 2240   2014( ISSN:0172-6390

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    DOI: 10.5754/hge13770

  • A Case of Pneumatosis Cystoides Intestinalis with Intraabdominal Free Air that was Difficult to Differentiate from an Intestinal Perforation Reviewed

    Togano Shingo, Shibutani Masatsune, Nagahara Hisashi, Ohtani Hiroshi, Sakurai Katsunobu, Tanaka Hiroaki, Muguruma Kazuya, Maeda Kiyoshi, Hirakawa Kosei

    Japanese Society for Abdominal Emergency Medicine, Progress in Acute Abdominal Medicine   34 ( 6 )   1205 - 1208   2014( ISSN:1340-2242

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    An 83-year-old woman had been hospitalized with symptoms of dementia. She consulted our department because abdominal plain computed tomography (CT) showed the presence of intraabdominal free air. We therefore performed an emergency operation because we could not rule out an intestinal perforation despite the absence of abdominal pain, a slight elevation of the inflammatory response and only a small degree of intestinal expansion on the CT findings. During surgery, a small degree of intestinal expansion and pneumatosis changes was observed over the tract and mesentery although no intra peritoneal contamination could be seen. Endoscopy was therefore performed during surgery and numerous sores and small ulcers were identified. We suspected pneumatosis cystoides intestinalis caused by ischemic changes in the mucous membrane and the presence of a nonsteroidal antiinflammatory drug-related ulcer, however, no definite diagnosis could be made. We finally diagnosed the patient as having intraabdominal free air caused by pneumatosis cystoides intestinalis and thus finished the operation as an exploratory laparotomy. It is difficult to decide whether or not to perform an operation in patients demonstrating pneumatosis cystoides intestinalis with intraabdominal free air because of the possibility of an intestinal perforation. It is therefore important to carefully evaluate the diagnostic data based on the physical, laboratory and imaging findings.

    DOI: 10.11231/jaem.34.1205

    CiNii Article

  • A Case of Appendectomy for Acute Appenidicitis that Occurred in the Bone Marrow Inhibition Stage of Acute Myelogenous Leukemia Reviewed

    NISHIO Kouhei, SHIBUTANI Masatsune, NAGAHARA Hisashi, OTANI Hiroshi, MAEDA Kiyoshi, HIRAKAWA Kosei

    Japan Surgical Association, The journal of the Japanese Practical Surgeon Society   75 ( 6 )   1616 - 1620   2014( ISSN:1345-2843

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    A 46-year-old male was diagnosed as having acute myelogenous leukemia. Anti-leukemic treatment was administered starting four days prior to the surgery. However, the patient complained of right lower abdominal pain one day prior to the surgery and was diagnosed on the same day as having acute appendicitis. The laboratory data showed pancytopenia, while abdominal examination revealed evidence of peritonitis. Therefore, laparoscopic appendectomy was performed. For approximately two weeks after the surgery, the pancytopenia and inflammation persisted. On the sixth day after the surgery, an abdominal CT showed abdominal wall cellulitis. Conservative treatment, including administration of antibiotics, was initiated. Starting on the 14th day after the surgery, the pancytopenia, inflammation and abdominal wall cellulitis began to improve. The patient was discharged on the 28th day after the surgery. Herein, we report our experience with a review of the pertinent literature.

    DOI: 10.3919/jjsa.75.1616

    CiNii Article

  • A Case of True Enterolith Accompanied by Stenosis of Anastomotic Part Reviewed

    Nishimura Junya, Nagahara Hisashi, Maeda Kiyoshi, Shibutani Masatsune, Noda Eiji, Hirakawa Kosei

    Japanese Society for Abdominal Emergency Medicine, Progress in Acute Abdominal Medicine   34 ( 4 )   915 - 918   2014( ISSN:1340-2242

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    Periodic computed tomography in a 76-year-old man under treatment for chronic HCV incidentally revealed the existence of a foreign object in the intestine. Double-balloon enteroscopy showed two strictures in the small intestine located 50 cm on the oral side from the end of the ileum together with bowel fluid accumulation and some enteroliths. Surgery was performed, because endoscopic extraction was impossible. During surgery, we observed two strictures and cystic dilation due to the previous partial resection of the small intestine caused by ileus which had been performed about 60 years previously. In the area of stenosis, three enteroliths measuring 2-4 cm were observed. Calculus analysis revealed that the main component of the enteroliths was deoxycholic acid and calcium oxalate. Most of the reported cases with true enteroliths have been accompanied by stenosis, diverticula or blind loops which obstructed intestinal emptying. In this paper we discussed 62 case reports of true enteroliths in the Japanese literature, including our case.

    DOI: 10.11231/jaem.34.915

    CiNii Article

  • A Case of Colon Perforation due to Cytomegalovirus Infection in a Patient Receiving Immunosuppressive Therapy Reviewed

    Shibutani Masatsune, Maeda Kiyoshi, Nagahara Hisashi, Ohtani Hiroshi, Tanaka Hiroaki, Muguruma Kazuya, Hirakawa Kosei

    Japanese Society for Abdominal Emergency Medicine, Progress in Acute Abdominal Medicine   34 ( 7 )   1369 - 1373   2014( ISSN:1340-2242

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    A 76-year-old man receiving immunosuppressive therapy for a skin disease had disseminated intravascular coagulation (DIC) caused by a pulmonary infection. He was transferred to our department under the diagnosis of perforation following bleeding from a gastric ulcer. Abdominal computed tomography revealed not only abdominal free air but also widespread subcutaneous emphysema and retroperitoneal emphysema. On the other hand, the patient had no abdominal symptoms and a laboratory examination indicated a minor inflammatory response. Based on these findings, we chose conservative therapy with a diagnosis of intramesenteric perforation of the colon. However, lower abdominal pain gradually appeared 5 days after starting conservative therapy and an emergency operation was therefore performed. On laparotomy, a perforation was present in the mesenteric side of the colon. Hartmann's operation was performed with resection of the perforated sigmoid colon. Histopathological and immunohistochemical examination revealed perforation due to cytomegalovirus infection. The patient's general condition improved gradually with intensive care, and finally he was able to be discharged. Although cytomegalovirus infection is often seen in patients receiving immunosuppressive therapy, gastrointestinal perforation due to cytomegalovirus infection is rare.

    DOI: 10.11231/jaem.34.1369

    CiNii Article

  • A Case of Appendectomy for Acute Appenidicitis that Occurred in the Bone Marrow Inhibition Stage of Acute Myelogenous Leukemia

    NISHIO Kouhei, SHIBUTANI Masatsune, NAGAHARA Hisashi, OTANI Hiroshi, MAEDA Kiyoshi, HIRAKAWA Kosei

    Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association)   75 ( 6 )   1616 - 1620   2014( ISSN:13452843

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    Publishing type:Research paper (scientific journal)  

    A 46-year-old male was diagnosed as having acute myelogenous leukemia. Anti-leukemic treatment was administered starting four days prior to the surgery. However, the patient complained of right lower abdominal pain one day prior to the surgery and was diagnosed on the same day as having acute appendicitis. The laboratory data showed pancytopenia, while abdominal examination revealed evidence of peritonitis. Therefore, laparoscopic appendectomy was performed. For approximately two weeks after the surgery, the pancytopenia and inflammation persisted. On the sixth day after the surgery, an abdominal CT showed abdominal wall cellulitis. Conservative treatment, including administration of antibiotics, was initiated. Starting on the 14th day after the surgery, the pancytopenia, inflammation and abdominal wall cellulitis began to improve. The patient was discharged on the 28th day after the surgery. Herein, we report our experience with a review of the pertinent literature.

    DOI: 10.3919/jjsa.75.1616

    CiNii Article

  • A Case of Pneumatosis Cystoides Intestinalis with Intraabdominal Free Air that was Difficult to Differentiate from an Intestinal Perforation Reviewed

    Togano Shingo, Shibutani Masatsune, Nagahara Hisashi, Ohtani Hiroshi, Sakurai Katsunobu, Tanaka Hiroaki, Muguruma Kazuya, Maeda Kiyoshi, Hirakawa Kosei

    Nihon Fukubu Kyukyu Igakkai Zasshi (Journal of Abdominal Emergency Medicine)   34 ( 6 )   1205 - 1208   2014( ISSN:13402242

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    Publishing type:Research paper (scientific journal)  

    An 83-year-old woman had been hospitalized with symptoms of dementia. She consulted our department because abdominal plain computed tomography (CT) showed the presence of intraabdominal free air. We therefore performed an emergency operation because we could not rule out an intestinal perforation despite the absence of abdominal pain, a slight elevation of the inflammatory response and only a small degree of intestinal expansion on the CT findings. During surgery, a small degree of intestinal expansion and pneumatosis changes was observed over the tract and mesentery although no intra peritoneal contamination could be seen. Endoscopy was therefore performed during surgery and numerous sores and small ulcers were identified. We suspected pneumatosis cystoides intestinalis caused by ischemic changes in the mucous membrane and the presence of a nonsteroidal antiinflammatory drug-related ulcer, however, no definite diagnosis could be made. We finally diagnosed the patient as having intraabdominal free air caused by pneumatosis cystoides intestinalis and thus finished the operation as an exploratory laparotomy. It is difficult to decide whether or not to perform an operation in patients demonstrating pneumatosis cystoides intestinalis with intraabdominal free air because of the possibility of an intestinal perforation. It is therefore important to carefully evaluate the diagnostic data based on the physical, laboratory and imaging findings.

    DOI: 10.11231/jaem.34.1205

    CiNii Article

  • A Case of Colon Perforation due to Cytomegalovirus Infection in a Patient Receiving Immunosuppressive Therapy Reviewed

    Shibutani Masatsune, Maeda Kiyoshi, Nagahara Hisashi, Ohtani Hiroshi, Tanaka Hiroaki, Muguruma Kazuya, Hirakawa Kosei

    Nihon Fukubu Kyukyu Igakkai Zasshi (Journal of Abdominal Emergency Medicine)   34 ( 7 )   1369 - 1373   2014( ISSN:13402242

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    Publishing type:Research paper (scientific journal)  

    A 76-year-old man receiving immunosuppressive therapy for a skin disease had disseminated intravascular coagulation (DIC) caused by a pulmonary infection. He was transferred to our department under the diagnosis of perforation following bleeding from a gastric ulcer. Abdominal computed tomography revealed not only abdominal free air but also widespread subcutaneous emphysema and retroperitoneal emphysema. On the other hand, the patient had no abdominal symptoms and a laboratory examination indicated a minor inflammatory response. Based on these findings, we chose conservative therapy with a diagnosis of intramesenteric perforation of the colon. However, lower abdominal pain gradually appeared 5 days after starting conservative therapy and an emergency operation was therefore performed. On laparotomy, a perforation was present in the mesenteric side of the colon. Hartmann’s operation was performed with resection of the perforated sigmoid colon. Histopathological and immunohistochemical examination revealed perforation due to cytomegalovirus infection. The patient’s general condition improved gradually with intensive care, and finally he was able to be discharged. Although cytomegalovirus infection is often seen in patients receiving immunosuppressive therapy, gastrointestinal perforation due to cytomegalovirus infection is rare.

    DOI: 10.11231/jaem.34.1369

    CiNii Article

  • A Case of True Enterolith Accompanied by Stenosis of Anastomotic Part Reviewed

    Nishimura Junya, Nagahara Hisashi, Maeda Kiyoshi, Shibutani Masatsune, Noda Eiji, Hirakawa Kosei

    Nihon Fukubu Kyukyu Igakkai Zasshi (Journal of Abdominal Emergency Medicine)   34 ( 4 )   915 - 918   2014( ISSN:13402242

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    Publishing type:Research paper (scientific journal)  

    Periodic computed tomography in a 76-year-old man under treatment for chronic HCV incidentally revealed the existence of a foreign object in the intestine. Double-balloon enteroscopy showed two strictures in the small intestine located 50 cm on the oral side from the end of the ileum together with bowel fluid accumulation and some enteroliths. Surgery was performed, because endoscopic extraction was impossible. During surgery, we observed two strictures and cystic dilation due to the previous partial resection of the small intestine caused by ileus which had been performed about 60 years previously. In the area of stenosis, three enteroliths measuring 2-4 cm were observed. Calculus analysis revealed that the main component of the enteroliths was deoxycholic acid and calcium oxalate. Most of the reported cases with true enteroliths have been accompanied by stenosis, diverticula or blind loops which obstructed intestinal emptying. In this paper we discussed 62 case reports of true enteroliths in the Japanese literature, including our case.

    DOI: 10.11231/jaem.34.915

    CiNii Article

  • Prognostic Value of Preoperative Inflammation-based Prognostic Scores in Patients with Stage IV Colorectal Cancer who Undergo Palliative Resection of Asymptomatic Primary Tumors Reviewed

    Maeda Kiyoshi, Shibutani Masatsune, Otani Hiroshi, Nagahara Hisashi, Sugano Kenji, Ikeya Tetsuro, Amano Ryosuke, Kimura Kenjiro, Sakurai Katsunobu, Kubo Naoshi, Muguruma Kazuya, Tanaka Hiroaki, Inoue Toru, Hirakawa Kosei

    ANTICANCER RESEARCH   33 ( 12 )   5567 - 5573   2013.12( ISSN:0250-7005

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  • 子宮頸癌術後に腹腔内膿瘍を契機に発見された転移性大腸癌の1例 Reviewed

    田内 潤, 永原 央, 澁谷 雅常, 野田 英児, 前田 清, 平川 弘聖

    日本臨床外科学会 日本臨床外科学会雑誌   74 ( 12 )   3405 - 3409   2013.12( ISSN:1345-2843

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    症例は44歳,女性.不正性器出血を契機に子宮頸癌IIb期,T2bN0M0と診断され,広汎子宮全摘術,両側卵巣吊り上げ術を施行された.術後7ヵ月頃から右側腹部痛を自覚し,CT検査所見にて右傍結腸溝に腹腔内膿瘍を認め,膿瘍腔造影では膿瘍腔と上行結腸の間に瘻孔を形成していた.膿瘍ドレナージを施行するも改善を認めず,右半結腸切除術,腹腔ドレナージ術を施行した.上行結腸に穿孔部位を認め,盲腸から上行結腸の外背側にかけて壁硬化像を認め,膿瘍腔を形成していた.病理診断にて穿孔部粘膜下層,漿膜側腫瘤付着部にsquamous cell carcinomaを認め,腫瘤には卵巣と卵管の組織が含まれていた.子宮頸癌上行結腸転移と診断された.悪性腫瘍の大腸転移は比較的稀な病態であり,今回われわれは子宮頸癌大腸転移の1例を経験したので若干の文献的考察をふまえて報告する.(著者抄録)

  • Prognostic value of preoperative inflammation-based prognostic scores in patients with stage IV colorectal cancer who undergo palliative resection of asymptomatic primary tumors. Reviewed

    Maeda K, Shibutani M, Otani H, Nagahara H, Sugano K, Ikeya T, Amano R, Kimura K, Sakurai K, Kubo N, Muguruma K, Tanaka H, Inoue T, Hirakawa K

    Anticancer research   33 ( 12 )   5567 - 73   2013.12( ISSN:0250-7005

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    PubMed

  • Prognostic Value of Preoperative Inflammation-based Prognostic Scores in Patients with Stage IV Colorectal Cancer who Undergo Palliative Resection of Asymptomatic Primary Tumors Reviewed

    Kiyoshi Maeda, Masatsune Shibutani, Hiroshi Otani, Hisashi Nagahara, Kenji Sugano, Tetsuro Ikeya, Ryosuke Amano, Kenjiro Kimura, Katsunobu Sakurai, Naoshi Kubo, Kazuya Muguruma, Hiroaki Tanaka, Toru Inoue, Kosei Hirakawa

    ANTICANCER RESEARCH   33 ( 12 )   5567 - 5573   2013.12( ISSN:0250-7005

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    Background: The need for palliative resection of asymptomatic primary tumor in patients with unresectable metastatic colorectal cancer (CRC) is still controversial. In order to identify predictors of survival after palliative resection, we investigated the correlations between clinicopathological factors, preoperative Glasgow prognostic score (GPS) and neutrophil-to-lymphocyte ratio (NLR), and survival. Patients and Methods: A total of 94 patients were enrolled in the present study. The prognostic value of the clinicopathological factors, GPS and NLR were analyzed retrospectively. Results: A multivariate analysis revealed that both the GPS and NLR were independent predictors of survival along with the preoperative Eastern Cooperative Oncology Group performance status (PS) and extent of distant metastasis. We classified the patients using a combination of these factors, and categorized them into three risk groups. The median survival time was five months in the high-risk group, compared to 21.5 months in the intermediate-risk group and 37 months in the low-risk group. Conclusion: Sub-classification based on the GPS, NLR, PS and extent of distant metastasis can classify patients into three independent groups. There may be no survival benefits associated with palliative resection in the high risk group.

  • Prognostic value of preoperative inflammation-based prognostic scores in patients with stage IV colorectal cancer who undergo palliative resection of asymptomatic primary tumors.

    Maeda K, Shibutani M, Otani H, Nagahara H, Sugano K, Ikeya T, Amano R, Kimura K, Sakurai K, Kubo N, Muguruma K, Tanaka H, Inoue T, Hirakawa K

    Anticancer research   33 ( 12 )   5567 - 73   2013.12( ISSN:0250-7005

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  • Prognostic value of preoperative inflammation-based prognostic scores in patients with stage IV colorectal cancer who undergo palliative resection of asymptomatic primary tumors. Reviewed

    Maeda K, Shibutani M, Otani H, Nagahara H, Sugano K, Ikeya T, Amano R, Kimura K, Sakurai K, Kubo N, Muguruma K, Tanaka H, Inoue T, Hirakawa K

    Anticancer research   33 ( 12 )   5567 - 73   2013.12( ISSN:0250-7005

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    PubMed

  • 子宮頸癌術後に腹腔内膿瘍を契機に発見された転移性大腸癌の1例

    田内 潤, 永原 央, 澁谷 雅常, 野田 英児, 前田 清, 平川 弘聖

    日本臨床外科学会雑誌   74 ( 12 )   3405 - 3409   2013.12( ISSN:1345-2843

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    症例は44歳,女性.不正性器出血を契機に子宮頸癌IIb期,T2bN0M0と診断され,広汎子宮全摘術,両側卵巣吊り上げ術を施行された.術後7ヵ月頃から右側腹部痛を自覚し,CT検査所見にて右傍結腸溝に腹腔内膿瘍を認め,膿瘍腔造影では膿瘍腔と上行結腸の間に瘻孔を形成していた.膿瘍ドレナージを施行するも改善を認めず,右半結腸切除術,腹腔ドレナージ術を施行した.上行結腸に穿孔部位を認め,盲腸から上行結腸の外背側にかけて壁硬化像を認め,膿瘍腔を形成していた.病理診断にて穿孔部粘膜下層,漿膜側腫瘤付着部にsquamous cell carcinomaを認め,腫瘤には卵巣と卵管の組織が含まれていた.子宮頸癌上行結腸転移と診断された.悪性腫瘍の大腸転移は比較的稀な病態であり,今回われわれは子宮頸癌大腸転移の1例を経験したので若干の文献的考察をふまえて報告する.(著者抄録)

  • [A case of familial adenomatous polyposis presenting with thyroid cancer]. Reviewed

    Shibutani M, Maeda K, Nagahara H, Noda E, Ohtani H, Takii M, Kimura K, Toyokawa T, Amano R, Kubo N, Tanaka H, Muguruma K, Onoda N, Ohira M, Higashiyama T, Hirakawa K

    Gan to kagaku ryoho. Cancer & chemotherapy   40 ( 12 )   2074 - 6   2013.11( ISSN:0385-0684

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  • Tumor Budding and E-Cadherin Expression Are Useful Predictors of Nodal Involvement in T1 Esophageal Squamous Cell Carcinoma Reviewed

    Nakagawa Yasuo, Ohira Masaichi, Kubo Naoshi, Yamashita Yoshito, Sakurai Katsunobu, Toyokawa Takahiro, Tanaka Hiroaki, Muguruma Kazuya, Shibutani Masatsune, Yamazoe Sadaaki, Kimura Kenjiro, Nagahara Hisashi, Amano Ryosuke, Ohtani Hiroshi, Yashiro Masakazu, Maeda Kiyoshi, Hirakawa Kosei

    ANTICANCER RESEARCH   33 ( 11 )   5023 - 5029   2013.11( ISSN:0250-7005

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  • Tumor budding and E-cadherin expression are useful predictors of nodal involvement in T1 esophageal squamous cell carcinoma. Reviewed

    Nakagawa Y, Ohira M, Kubo N, Yamashita Y, Sakurai K, Toyokawa T, Tanaka H, Muguruma K, Shibutani M, Yamazoe S, Kimura K, Nagahara H, Amano R, Ohtani H, Yashiro M, Maeda K, Hirakawa K

    Anticancer research   33 ( 11 )   5023 - 9   2013.11( ISSN:0250-7005

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  • Tumor Budding and E-Cadherin Expression Are Useful Predictors of Nodal Involvement in T1 Esophageal Squamous Cell Carcinoma Reviewed

    Nakagawa Yasuo, Ohira Masaichi, Kubo Naoshi, Yamashita Yoshito, Sakurai Katsunobu, Toyokawa Takahiro, Tanaka Hiroaki, Muguruma Kazuya, Shibutani Masatsune, Yamazoe Sadaaki, Kimura Kenjiro, Nagahara Hisashi, Amano Ryosuke, Ohtani Hiroshi, Yashiro Masakazu, Maeda Kiyoshi, Hirakawa Kosei

    ANTICANCER RESEARCH   33 ( 11 )   5023 - 5029   2013.11( ISSN:0250-7005

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  • Meta-analysis of Laparoscopic and Open Surgery for Gastric Gastrointestinal Stromal Tumor Reviewed

    Ohtani Hiroshi, Maeda Kiyoshi, Noda Eiji, Nagahara Hisashi, Shibutani Masatune, Ohira Masaichi, Muguruma Kazuya, Tanaka Hiroaki, Kubo Naoshi, Toyokawa Takahiro, Sakurai Katsunori, Yamashita Yoshito, Yamamoto Atsushi, Hirakawa Kosei

    ANTICANCER RESEARCH   33 ( 11 )   5031 - 5041   2013.11( ISSN:0250-7005

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  • [Successful treatment of locally advanced squamous cell carcinoma of the esophagus by combination chemotherapy with 5-fluorouracil plus nedaplatin following tracheal stent tube placement-a case report]. Reviewed

    Nishimura J, Kubo N, Lee T, Shinto O, Sakurai K, Toyokawa T, Tanaka H, Muguruma K, Shibutani M, Yamazoe S, Nagahara H, Kimura K, Amano R, Ohtani H, Yashiro M, Maeda K, Ohira M, Hirakawa K

    Gan to kagaku ryoho. Cancer & chemotherapy   40 ( 12 )   2112 - 4   2013.11( ISSN:0385-0684

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  • [Significance of preoperative neutrophil-to-lymphocyte ratio as a predictor of prognosis in patients with stage IV colorectal cancer]. Reviewed

    Shibutani M, Maeda K, Nagahara H, Noda E, Ohtani H, Sugano K, Takii M, Kimura K, Toyokawa T, Amano R, Kubo N, Tanaka H, Muguruma K, Ohira M, Hirakawa K

    Gan to kagaku ryoho. Cancer & chemotherapy   40 ( 12 )   1603 - 5   2013.11( ISSN:0385-0684

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  • [Five cases of severe radiation pneumonitis after chemoradiotherapy for esophageal cancer]. Reviewed

    Sakurai K, Kubo N, Shibutani M, Yamazoe S, Kimura K, Nagahara H, Toyokawa T, Amano R, Tanaka H, Muguruma K, Ohtani H, Yashiro M, Maeda K, Ohira M, Hirakawa K

    Gan to kagaku ryoho. Cancer & chemotherapy   40 ( 12 )   2139 - 42   2013.11( ISSN:0385-0684

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  • [A case of familial adenomatous polyposis presenting with thyroid cancer]. Reviewed

    Shibutani M, Maeda K, Nagahara H, Noda E, Ohtani H, Takii M, Kimura K, Toyokawa T, Amano R, Kubo N, Tanaka H, Muguruma K, Onoda N, Ohira M, Higashiyama T, Hirakawa K

    Gan to kagaku ryoho. Cancer & chemotherapy   40 ( 12 )   2074 - 6   2013.11( ISSN:0385-0684

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  • Meta-analysis of Laparoscopic and Open Surgery for Gastric Gastrointestinal Stromal Tumor Reviewed

    Hiroshi Ohtani, Kiyoshi Maeda, Eiji Noda, Hisashi Nagahara, Masatune Shibutani, Masaichi Ohira, Kazuya Muguruma, Hiroaki Tanaka, Naoshi Kubo, Takahiro Toyokawa, Katsunori Sakurai, Yoshito Yamashita, Atsushi Yamamoto, Kosei Hirakawa

    ANTICANCER RESEARCH   33 ( 11 )   5031 - 5041   2013.11( ISSN:0250-7005

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    Aim: A meta-analysis was conducted to evaluate and compare the short- and long-term outcomes of laparoscopic and conventional open surgery for gastric gastrointestinal stromal tumors (GISTs). Materials and Methods: We searched MEDLINE, EMBASE, Science Citation Index, and the Cochrane Controlled Trial Register for relevant articles published between 2000 and July 2013 by using the search terms "laparoscopic", "laparoscopy-assisted", "surgery", "gastrointestinal tumor", "GIST" and "gastric". Results: We identified 12 articles reporting results that compared laparoscopic surgery with open surgery for gastric GISTs. Our meta-analysis included 644 patients with GISTs; 312 had undergone laparoscopic surgery, and 332 had undergone open surgery. In the short-term period, 14 outcome variables were examined. In the long-term period, six oncological variables were analyzed. Laparoscopic surgery for gastric GIST was associated with a reduction in intraoperative blood loss, shorter period to flatus, earlier resumption of oral intake, and shorter duration of hospital stay over the short-term, and with a significantly lower rate of overall recurrence, metastatic recurrence and local recurrence in the long-term compared to open surgery. Conclusion: Laparoscopic surgery may be an acceptable surgical treatment option compared to open surgery for gastric GIST.

  • [Successful treatment of locally advanced squamous cell carcinoma of the esophagus by combination chemotherapy with 5-fluorouracil plus nedaplatin following tracheal stent tube placement-a case report].

    Nishimura J, Kubo N, Lee T, Shinto O, Sakurai K, Toyokawa T, Tanaka H, Muguruma K, Shibutani M, Yamazoe S, Nagahara H, Kimura K, Amano R, Ohtani H, Yashiro M, Maeda K, Ohira M, Hirakawa K

    Gan to kagaku ryoho. Cancer & chemotherapy   40 ( 12 )   2112 - 4   2013.11( ISSN:0385-0684

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  • [Successful treatment of locally advanced squamous cell carcinoma of the esophagus by combination chemotherapy with 5-fluorouracil plus nedaplatin following tracheal stent tube placement-a case report]. Reviewed

    Nishimura J, Kubo N, Lee T, Shinto O, Sakurai K, Toyokawa T, Tanaka H, Muguruma K, Shibutani M, Yamazoe S, Nagahara H, Kimura K, Amano R, Ohtani H, Yashiro M, Maeda K, Ohira M, Hirakawa K

    Gan to kagaku ryoho. Cancer & chemotherapy   40 ( 12 )   2112 - 4   2013.11( ISSN:0385-0684

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    Publishing type:Research paper (scientific journal)  

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  • [Significance of preoperative neutrophil-to-lymphocyte ratio as a predictor of prognosis in patients with stage IV colorectal cancer].

    Shibutani M, Maeda K, Nagahara H, Noda E, Ohtani H, Sugano K, Takii M, Kimura K, Toyokawa T, Amano R, Kubo N, Tanaka H, Muguruma K, Ohira M, Hirakawa K

    Gan to kagaku ryoho. Cancer & chemotherapy   40 ( 12 )   1603 - 5   2013.11( ISSN:0385-0684

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  • [Significance of preoperative neutrophil-to-lymphocyte ratio as a predictor of prognosis in patients with stage IV colorectal cancer]. Reviewed

    Shibutani M, Maeda K, Nagahara H, Noda E, Ohtani H, Sugano K, Takii M, Kimura K, Toyokawa T, Amano R, Kubo N, Tanaka H, Muguruma K, Ohira M, Hirakawa K

    Gan to kagaku ryoho. Cancer & chemotherapy   40 ( 12 )   1603 - 5   2013.11( ISSN:0385-0684

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    Publishing type:Research paper (scientific journal)  

    PubMed

  • [Five cases of severe radiation pneumonitis after chemoradiotherapy for esophageal cancer].

    Sakurai K, Kubo N, Shibutani M, Yamazoe S, Kimura K, Nagahara H, Toyokawa T, Amano R, Tanaka H, Muguruma K, Ohtani H, Yashiro M, Maeda K, Ohira M, Hirakawa K

    Gan to kagaku ryoho. Cancer & chemotherapy   40 ( 12 )   2139 - 42   2013.11( ISSN:0385-0684

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  • [Five cases of severe radiation pneumonitis after chemoradiotherapy for esophageal cancer]. Reviewed

    Sakurai K, Kubo N, Shibutani M, Yamazoe S, Kimura K, Nagahara H, Toyokawa T, Amano R, Tanaka H, Muguruma K, Ohtani H, Yashiro M, Maeda K, Ohira M, Hirakawa K

    Gan to kagaku ryoho. Cancer & chemotherapy   40 ( 12 )   2139 - 42   2013.11( ISSN:0385-0684

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    PubMed

  • [A case of familial adenomatous polyposis presenting with thyroid cancer].

    Shibutani M, Maeda K, Nagahara H, Noda E, Ohtani H, Takii M, Kimura K, Toyokawa T, Amano R, Kubo N, Tanaka H, Muguruma K, Onoda N, Ohira M, Higashiyama T, Hirakawa K

    Gan to kagaku ryoho. Cancer & chemotherapy   40 ( 12 )   2074 - 6   2013.11( ISSN:0385-0684

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  • Tumor Budding and E-Cadherin Expression Are Useful Predictors of Nodal Involvement in T1 Esophageal Squamous Cell Carcinoma Reviewed

    Nakagawa Yasuo, Ohira Masaichi, Kubo Naoshi, Yamashita Yoshito, Sakurai Katsunobu, Toyokawa Takahiro, Tanaka Hiroaki, Muguruma Kazuya, Shibutani Masatsune, Yamazoe Sadaaki, Kimura Kenjiro, Nagahara Hisashi, Amano Ryosuke, Ohtani Hiroshi, Yashiro Masakazu, Maeda Kiyoshi, Hirakawa Kosei

    ANTICANCER RESEARCH   33 ( 11 )   5023 - 5029   2013.11( ISSN:0250-7005

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  • Tumor budding and E-cadherin expression are useful predictors of nodal involvement in T1 esophageal squamous cell carcinoma.

    Nakagawa Y, Ohira M, Kubo N, Yamashita Y, Sakurai K, Toyokawa T, Tanaka H, Muguruma K, Shibutani M, Yamazoe S, Kimura K, Nagahara H, Amano R, Ohtani H, Yashiro M, Maeda K, Hirakawa K

    Anticancer research   33 ( 11 )   5023 - 9   2013.11( ISSN:0250-7005

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  • Tumor budding and E-cadherin expression are useful predictors of nodal involvement in T1 esophageal squamous cell carcinoma Reviewed

    Yasuo Nakagawa, Masaichi Ohira, Naoshi Kubo, Yoshito Yamashita, Katsunobu Sakurai, Takahiro Toyokawa, Hiroaki Tanaka, Kazuya Muguruma, Masatsune Shibutani, Sadaaki Yamazoe, Kenjiro Kimura, Hisashi Nagahara, Ryosuke Amano, Hiroshi Ohtani, Masakazu Yashiro, Kiyoshi Maeda, Kosei Hirakawa

    Anticancer Research   33 ( 11 )   5023 - 5030   2013.11( ISSN:0250-7005

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    Background: Endoscopic treatment has been increasingly used for T1 esophageal squamous cell carcinoma (ESCC). However, this therapy is sometimes incomplete if the depth of the T1 primary tumor reaches the muscularis mucosae or submucosal layer because these tumors have a relatively high incidence of lymph node metastasis. However, to our knowledge, no previous reports on the prediction of nodal metastasis determined by evaluating primary tumor specimens of patients with ESCC are available. Patients and Methods: A total of 55 patients with T1 ESCC invading as deep as the submucosal layer who underwent curative esophagectomy were examined. We investigated the significance of the immunohistochemical staining of Vascular endothelial growth factor-C (VEGF-C) and E-cadherin in the primary tumor and Tumor budding for prediction of nodal metastasis. Results: Metastasis to the regional lymph nodes was observed in 26 cases (47.3%) in this setting. VEGF-C expression and reduced E-Cadherin expression in the primary tumor was observed in 32 (58.1%) and 38 cases (69.1%), respectively. High-grade tumor budding was observed in 29 cases (52.7%). E-cadherin expression and tumor budding were closely correlated with nodal metastasis (p=0.04 and &lt
    0.01 respectively), whereas VEGF-C expression tended to correlate with lymph node metastasis (p=0.06). In addition, high-grade tumor budding was significantly correlated (p&lt
    0.01) with reduced E-cadherin expression. The accuracy of tumor budding and E-cadherin expression for nodal metastasis were 67.3% and 65.4% respectively, comparable with the one of lymphatic involvement (63%). Tumor budding (p&lt
    0.01), but not E-cadherin and VEGF-C expression, was significantly correlated with poor survival. Conclusion: After the endoscopic treatment, additional therapy, such as surgery or chemoradiotherapy, may be required if reduced E-cadherin expression and high-grade tumor budding are observed in primary tumor specimen.

    PubMed

  • Meta-analysis of laparoscopic and open surgery for gastric gastrointestinal stromal tumor.

    Ohtani H, Maeda K, Noda E, Nagahara H, Shibutani M, Ohira M, Muguruma K, Tanaka H, Kubo N, Toyokawa T, Sakurai K, Yamashita Y, Yamamoto A, Hirakawa K

    Anticancer research   33 ( 11 )   5031 - 41   2013.11( ISSN:0250-7005

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  • [Promising effects of pregabalin in the treatment of oxaliplatin-induced sensory neuropathy in patients with colorectal carcinoma]. Reviewed

    Nagahara H, Noda E, Maeda K, Inoue T, Hirakawa T, Hasegawa T, Shibutani M, Hirakawa K

    Gan to kagaku ryoho. Cancer & chemotherapy   40 ( 9 )   1181 - 3   2013.09( ISSN:0385-0684

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  • [Promising effects of pregabalin in the treatment of oxaliplatin-induced sensory neuropathy in patients with colorectal carcinoma].

    Nagahara H, Noda E, Maeda K, Inoue T, Hirakawa T, Hasegawa T, Shibutani M, Hirakawa K

    Gan to kagaku ryoho. Cancer & chemotherapy   40 ( 9 )   1181 - 3   2013.09( ISSN:0385-0684

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  • A high preoperative neutrophil-to-lymphocyte ratio is associated with poor survival in patients with colorectal cancer.

    Anticancer Res.   2013.08

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  • A high preoperative neutrophil-to-lymphocyte ratio is associated with poor survival in patients with colorectal cancer. Reviewed

    Anticancer Res.   2013.08

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    Publishing type:Research paper (scientific journal)   Kind of work:Single Work  

  • Low expression of claudin-1 and presence of poorly-differentiated tumor clusters correlate with poor prognosis in colorectal cancer. Reviewed

    Shibutani M, Noda E, Maeda K, Nagahara H, Ohtani H, Hirakawa K

    Anticancer research   33 ( 8 )   3301 - 6   2013.08( ISSN:0250-7005

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  • Low Expression of Claudin-1 and Presence of Poorly-differentiated Tumor Clusters Correlate with Poor Prognosis in Colorectal Cancer Reviewed

    Shibutani Masatsune, Noda Eiji, Maeda Kiyoshi, Nagahara Hisashi, Ohtani Hiroshi, Hirakawa Kosei

    ANTICANCER RESEARCH   33 ( 8 )   3301 - 3306   2013.08( ISSN:0250-7005

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  • A high preoperative neutrophil-to-lymphocyte ratio is associated with poor survival in patients with colorectal cancer. Reviewed

    Shibutani M, Maeda K, Nagahara H, Noda E, Ohtani H, Nishiguchi Y, Hirakawa K

    Anticancer research   33 ( 8 )   3291 - 4   2013.08( ISSN:0250-7005

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  • A High Preoperative Neutrophil-to-lymphocyte Ratio Is Associated with Poor Survival in Patients with Colorectal Cancer Reviewed

    Shibutani Masatsune, Maeda Kiyoshi, Nagahara Hisashi, Noda Eiji, Ohtani Hiroshi, Nishiguchi Yukio, Hirakawa Kosei

    ANTICANCER RESEARCH   33 ( 8 )   3291 - 3294   2013.08( ISSN:0250-7005

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  • A High Preoperative Neutrophil-to-lymphocyte Ratio Is Associated with Poor Survival in Patients with Colorectal Cancer Reviewed

    Masatsune Shibutani, Kiyoshi Maeda, Hisashi Nagahara, Eiji Noda, Hiroshi Ohtani, Yukio Nishiguchi, Kosei Hirakawa

    ANTICANCER RESEARCH   33 ( 8 )   3291 - 3294   2013.08( ISSN:0250-7005

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    Background: Previous studies have reported that an elevated preoperative neutrophil-to-lymphocyte ratio (NLR) is associated with a poor prognosis in patients with various types of cancers. The aim of this study was to determine the prognostic significance of preoperative NLR in patients with colorectal cancer and to determine an appropriate cut-off value of the NLR. Patients and Methods: We enrolled 674 patients who underwent surgery for stage I-IV colorectal cancer. The mean NLR was 2.74 +/- 2.20. To determine the appropriate cut-off value of the NLR, we used a receiver operating characteristic curve. A total of 262 patients with an NLR of 2.5 or more were classified as high-NLR individuals in this study. The prognostic significance of a high NLR was evaluated using a multivariate analysis. Results: The cancer-specific survival was significantly (p&lt;0.001) worse in the patients with a high NLR. The multivariate analysis indicated that the tumor diameter, the presence of lymph node or distant metastasis, and a high NLR were independent risk factors for poor survival. Conclusion: Preoperative NLR measurement is a convenient biomarker and predictor of a poor prognosis after surgery for colorectal cancer.

  • Low expression of claudin-1 and presence of poorly-differentiated tumor clusters correlate with poor prognosis in colorectal cancer.

    Shibutani M, Noda E, Maeda K, Nagahara H, Ohtani H, Hirakawa K

    Anticancer research   33 ( 8 )   3301 - 6   2013.08( ISSN:0250-7005

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  • Low expression of claudin-1 and presence of poorly-differentiated tumor clusters correlate with poor prognosis in colorectal cancer. Reviewed

    澁谷 雅常

    Anticancer Res.   33 ( 8 )   3301 - 6   2013.08( ISSN:0250-7005

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  • Low expression of claudin-1 and presence of poorly-differentiated tumor clusters correlate with poor prognosis in colorectal cancer. Reviewed

    Shibutani M, Noda E, Maeda K, Nagahara H, Ohtani H, Hirakawa K

    Anticancer research   33 ( 8 )   3301 - 6   2013.08( ISSN:0250-7005

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  • Low Expression of Claudin-1 and Presence of Poorly-differentiated Tumor Clusters Correlate with Poor Prognosis in Colorectal Cancer Reviewed

    Masatsune Shibutani, Eiji Noda, Kiyoshi Maeda, Hisashi Nagahara, Hiroshi Ohtani, Kosei Hirakawa

    ANTICANCER RESEARCH   33 ( 8 )   3301 - 3306   2013.08( ISSN:0250-7005

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    Background: Claudins are integral membrane proteins that constitute tight junctions. The aim of this study was to determine the clinical significance of claudin-1 in terms of the cell-cell adhesion, considering the poorly-differentiated tumor component. Patients and Methods: A total of 344 cases of stage II and III colorectal cancer were enrolled. We evaluated the expression of claudin-1 by immunohistochemistry and the extent of the poorly differentiated component. Results: Low expression of claudin-1 was associated with lymphatic involvement, histological differentiation, extent of poorly-differentiated component, reduced disease-free and overall survival. Multivariate analysis indicated that lymph node metastasis, venous involvement and low claudin-1 expression were independent predictors of recurrence, and that lymph node metastasis, venous involvement and low claudin-1 expression were associated with poor survival. Conclusion: Our study not only showed the significance of low expression of claudin-1 as a predictor of poor prognosis of colorectal cancer but also supported the concept of grading of the poorly-differentiated component.

  • A high preoperative neutrophil-to-lymphocyte ratio is associated with poor survival in patients with colorectal cancer.

    Shibutani M, Maeda K, Nagahara H, Noda E, Ohtani H, Nishiguchi Y, Hirakawa K

    Anticancer research   33 ( 8 )   3291 - 4   2013.08( ISSN:0250-7005

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  • A high preoperative neutrophil-to-lymphocyte ratio is associated with poor survival in patients with colorectal cancer. Reviewed

    Shibutani M, Maeda K, Nagahara H, Noda E, Ohtani H, Nishiguchi Y, Hirakawa K

    Anticancer research   33 ( 8 )   3291 - 4   2013.08( ISSN:0250-7005

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    PubMed

  • A high preoperative neutrophil-to-lymphocyte ratio is associated with poor survival in patients with colorectal cancer.

    Anticancer Res.   2013.08

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  • Low expression of claudin-1 and presence of poorly-differentiated tumor clusters correlate with poor prognosis in colorectal cancer.

    Anticancer Res.   2013.06

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  • Low expression of claudin-1 and presence of poorly-differentiated tumor clusters correlate with poor prognosis in colorectal cancer. Reviewed

    Anticancer Res.   2013.06

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  • A CASE OF UNDIFFERNTIATED CARCINOMA OF SIGMOID COLON WITH EXTRALUMINAL GROWTH IN WHICH THE PATIENT DIED SHORTLY AFTER CURATIVE OPERATION Reviewed

    SHIBUTANI Masatsune, MAEDA Kiyoshi, NAGAHARA Hisashi, NODA Eiji, OHTANI Hiroshi, OHSAWA Masahiko, HIRAKAWA Kosei

    Japan Surgical Association, The journal of the Japanese Practical Surgeon Society   74 ( 5 )   1321 - 1325   2013.05( ISSN:13452843

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    A 69-year-old man was admitted for left lower abdominal pain computed tomography (CT) scan found a tumor of the sigmoid colon with extraluminal growth. Based on a diagnosis of malignat tumor-like gastrointestinal stromal tumor (GIST), we conducted a sigmoidectomy. Histopathological examination showed no findings suggestive of endocrine cell carcinoma, so that undifferentiated carcinoma was diagnosed. The depth of tumor invasion was SE, no lymph node metastasis were seen, and it was in stage II. He developed peritoneal metastasis after about 1 month and died of cancer 2 months after the curative operation without chemotherapy.<BR>An undifferentiated colorectal carcinoma is very rare and its prognosis is very poor. Colorectal cancer with extraluminal growth is also rare and often detected after progression because of poor symptoms.<BR>We report a case of undifferentiated carcinoma of the sigmoid colon with extraluminal growth who died only 2 months after a curative operation.

    DOI: 10.3919/jjsa.74.1321

    CiNii Article

  • PS-071-3 深達度pT1,pT2直腸癌における局所再発危険因子の検討(PS ポスターセッション,第113回日本外科学会定期学術集会) Reviewed

    菅野 兼史, 野田 英児, 前田 清, 永原 央, 渋谷 雅常, 柏木 伸一郎, 木村 健二郎, 川尻 成美, 天野 良亮, 久保 尚士, 田中 浩明, 六車 一哉, 高島 勉, 小野田 尚佳, 仲田 文造, 大平 雅一, 平川 弘聖

    一般社団法人日本外科学会 日本外科学会雑誌   114 ( 2 )   2013.03( ISSN:18801129

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  • PS-198-3 大腸癌における予後予測因子としての術前好中球・リンパ球比の有用性(PS ポスターセッション,第113回日本外科学会定期学術集会) Reviewed

    渋谷 雅常, 前田 清, 野田 英児, 永原 央, 菅野 兼史, 木村 健二郎, 天野 良亮, 久保 尚士, 田中 浩明, 六車 一哉, 井上 透, 西口 幸雄, 大平 雅一, 平川 弘聖

    一般社団法人日本外科学会 日本外科学会雑誌   114 ( 2 )   2013.03( ISSN:18801129

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    CiNii Article

  • PS-182-6 切除不能進行・再発原発性小腸癌に対する化学療法(PS ポスターセッション,第113回日本外科学会定期学術集会) Reviewed

    奥野 倫久, 前田 清, 野田 英児, 永原 央, 渋谷 雅常, 菅野 兼史, 柏木 伸一郎, 川尻 成美, 木村 健二郎, 天野 良亮, 久保 尚士, 田中 浩明, 六車 一哉, 高島 勉, 井上 透, 西口 幸雄, 仲田 文造, 大平 雅一, 池原 照幸, 平川 弘聖

    一般社団法人日本外科学会 日本外科学会雑誌   114 ( 2 )   2013.03( ISSN:18801129

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  • PS-076-3 大腸癌早期再発症例の臨床病理学的検討(PS ポスターセッション,第113回日本外科学会定期学術集会) Reviewed

    野田 英児, 前田 清, 永原 央, 渋谷 雅常, 菅野 兼史, 木村 健二郎, 天野 良亮, 久保 尚士, 田中 浩明, 六車 一哉, 柏木 伸一郎, 川尻 成美, 高島 勉, 小野田 尚佳, 井上 透, 西口 幸雄, 仲田 文造, 大平 雅一, 池原 照幸, 平川 弘聖

    一般社団法人日本外科学会 日本外科学会雑誌   114 ( 2 )   2013.03( ISSN:18801129

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    CiNii Article

  • PS-071-3 深達度pT1,pT2直腸癌における局所再発危険因子の検討(PS ポスターセッション,第113回日本外科学会定期学術集会) Reviewed

    菅野 兼史, 野田 英児, 前田 清, 永原 央, 渋谷 雅常, 柏木 伸一郎, 木村 健二郎, 川尻 成美, 天野 良亮, 久保 尚士, 田中 浩明, 六車 一哉, 高島 勉, 小野田 尚佳, 仲田 文造, 大平 雅一, 平川 弘聖

    一般社団法人日本外科学会 日本外科学会雑誌   114 ( 2 )   2013.03( ISSN:1880-1129

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    CiNii Article

  • PS-198-3 大腸癌における予後予測因子としての術前好中球・リンパ球比の有用性(PS ポスターセッション,第113回日本外科学会定期学術集会)

    渋谷 雅常, 前田 清, 野田 英児, 永原 央, 菅野 兼史, 木村 健二郎, 天野 良亮, 久保 尚士, 田中 浩明, 六車 一哉, 井上 透, 西口 幸雄, 大平 雅一, 平川 弘聖

    日本外科学会雑誌   114 ( 2 )   797   2013.03( ISSN:18801129

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  • PS-198-3 大腸癌における予後予測因子としての術前好中球・リンパ球比の有用性(PS ポスターセッション,第113回日本外科学会定期学術集会) Reviewed

    渋谷 雅常, 前田 清, 野田 英児, 永原 央, 菅野 兼史, 木村 健二郎, 天野 良亮, 久保 尚士, 田中 浩明, 六車 一哉, 井上 透, 西口 幸雄, 大平 雅一, 平川 弘聖

    一般社団法人日本外科学会 日本外科学会雑誌   114 ( 2 )   2013.03( ISSN:1880-1129

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    CiNii Article

  • PS-182-6 切除不能進行・再発原発性小腸癌に対する化学療法(PS ポスターセッション,第113回日本外科学会定期学術集会) Reviewed

    奥野 倫久, 前田 清, 野田 英児, 永原 央, 渋谷 雅常, 菅野 兼史, 柏木 伸一郎, 川尻 成美, 木村 健二郎, 天野 良亮, 久保 尚士, 田中 浩明, 六車 一哉, 高島 勉, 井上 透, 西口 幸雄, 仲田 文造, 大平 雅一, 池原 照幸, 平川 弘聖

    一般社団法人日本外科学会 日本外科学会雑誌   114 ( 2 )   2013.03( ISSN:1880-1129

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    Publishing type:Research paper (scientific journal)  

    CiNii Article

  • PS-182-6 切除不能進行・再発原発性小腸癌に対する化学療法(PS ポスターセッション,第113回日本外科学会定期学術集会)

    奥野 倫久, 前田 清, 野田 英児, 永原 央, 渋谷 雅常, 菅野 兼史, 柏木 伸一郎, 川尻 成美, 木村 健二郎, 天野 良亮, 久保 尚士, 田中 浩明, 六車 一哉, 高島 勉, 井上 透, 西口 幸雄, 仲田 文造, 大平 雅一, 池原 照幸, 平川 弘聖

    日本外科学会雑誌   114 ( 2 )   774   2013.03( ISSN:18801129

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  • PS-076-3 大腸癌早期再発症例の臨床病理学的検討(PS ポスターセッション,第113回日本外科学会定期学術集会)

    野田 英児, 前田 清, 永原 央, 渋谷 雅常, 菅野 兼史, 木村 健二郎, 天野 良亮, 久保 尚士, 田中 浩明, 六車 一哉, 柏木 伸一郎, 川尻 成美, 高島 勉, 小野田 尚佳, 井上 透, 西口 幸雄, 仲田 文造, 大平 雅一, 池原 照幸, 平川 弘聖

    日本外科学会雑誌   114 ( 2 )   625   2013.03( ISSN:18801129

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  • PS-076-3 大腸癌早期再発症例の臨床病理学的検討(PS ポスターセッション,第113回日本外科学会定期学術集会) Reviewed

    野田 英児, 前田 清, 永原 央, 渋谷 雅常, 菅野 兼史, 木村 健二郎, 天野 良亮, 久保 尚士, 田中 浩明, 六車 一哉, 柏木 伸一郎, 川尻 成美, 高島 勉, 小野田 尚佳, 井上 透, 西口 幸雄, 仲田 文造, 大平 雅一, 池原 照幸, 平川 弘聖

    一般社団法人日本外科学会 日本外科学会雑誌   114 ( 2 )   2013.03( ISSN:1880-1129

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    CiNii Article

  • PS-071-3 深達度pT1,pT2直腸癌における局所再発危険因子の検討(PS ポスターセッション,第113回日本外科学会定期学術集会)

    菅野 兼史, 野田 英児, 前田 清, 永原 央, 渋谷 雅常, 柏木 伸一郎, 木村 健二郎, 川尻 成美, 天野 良亮, 久保 尚士, 田中 浩明, 六車 一哉, 高島 勉, 小野田 尚佳, 仲田 文造, 大平 雅一, 平川 弘聖

    日本外科学会雑誌   114 ( 2 )   618   2013.03( ISSN:18801129

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  • Six Cases of Colorectal and Small Bowel Cancer Associated with Crohn's Disease Reviewed

    Takii Mamiko, Maeda Kiyoshi, Nagahara Hisashi, Noda Eiji, Shibutani Masatsune, Kamata Noriko, Mitsue Sogawa, Yamagami Hirokazu, Watanabe Kenji, Hirakawa Kousei

    The Japan Society of Coloproctology, The Japanese journal of proctology   66 ( 4 )   229 - 233   2013( ISSN:0047-1801

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    Although the number of reports of colorectal and small bowel cancer associated with Crohn's disease (CD) has been increasing, there have been few studies on the characteristics and clinical outcomes of CD-associated cancer. We herein report six cases of colorectal and small bowel cancer associated with Crohn's disease treated from January 2001 to May 2011. Their average age was 40.0 years. All of them had been suffering from Crohn's disease for more than 10 years. There was one patient with stage I cancer, three patients with stage II, and one patient with stage IV. We were able to perform a curative resection in five cases, and disease recurrence was observed in one patient. The recent remarkable progress in medical treatments has contributed to improvements in the clinical outcome; however, careful surveillance for the occurrence of CD-associated cancer is necessary. Surveillance for the early diagnosis of neoplastic lesions can enable treatment and thus a better outcome.

    DOI: 10.3862/jcoloproctology.66.229

    CiNii Article

  • A Case of Metastatic Colon Cancer Detected due to an Intra-abdominal Abscess following Surgery for Cervical Cancer Reviewed

    TAUCHI Jun, NAGAHARA Hisashi, SHIBUTANI Masatune, NODA Eiji, MAEDA Kiyoshi, HIRAKAWA Kosei

    Japan Surgical Association, The journal of the Japanese Practical Surgeon Society   74 ( 12 )   3405 - 3409   2013( ISSN:1345-2843

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    A woman 44 years old was diagnosed with stage IIb, T2bN0M0 cervical cancer following atypical genital bleeding, and she underwent radical hysterectomy and bilateral ovarian lift surgery. The patient developed right-sided abdominal pain from around seven months postoperatively, and computed tomography (CT) examination showed an intra-abdominal abscess in the right paracolic gutter, while imaging of the abscess cavity showed formation of a fistula between the abscess cavity and the ascending colon. Since no improvements were seen following abscess drainage, right hemicolectomy and peritoneal drainage were performed. A perforation was found in the ascending colon, and wall hardening was seen from the cecum to the lateral posterior side of the ascending colon, with formation of an abscess cavity. The pathological diagnosis was squamous cell carcinoma in the submucosa of the perforation site and the attachment site of the tumor on the serosal side, and the tumor contained tissues from the ovaries and the oviduct. A diagnosis of cervical cancer metastasis to the ascending colon was made. Since colonic metastasis of malignant tumors is a relatively rare condition, this case of colonic metastasis of cervical cancer is reported in the context of the relevant literature.

    DOI: 10.3919/jjsa.74.3405

    CiNii Article

  • A Case of Adrenal Crisis after Operation due to Bilateral Adrenal Metastasis of Undifferentiated Carcinoma of the Small Intestine Reviewed

    SHIBUTANI Masatsune, MAEDA Kiyoshi, OHTANI Hiroshi, NAGAHARA Hisashi, NODA Eiji, SAKABE Manami, OSAWA Masahiko, HIRAKAWA Kosei

    Japan Surgical Association, The journal of the Japanese Practical Surgeon Society   74 ( 10 )   2901 - 2905   2013( ISSN:1345-2843

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    An 81-year-old man was admitted to our hospital because of bleeding from carcinoma of the small intestine. Although an abdominal computed tomography (CT) scan showed bilateral adrenal metastasis and paraaortic lymph node metastasis, partial resection of the small intestine was performed to control the bleeding. The morning after the operation, he entered a state of shock. Adrenal insufficiency was suspected because of low blood pressure, hypoglycemia and hyperkalemia. His symptoms were dramatically improved by hydrocortisone treatment.<BR>He was diagnosed with undifferentiated carcinoma of the small intestine by histopathological and immunohistochemical examination.<BR>An undifferentiated carcinoma of the small intestine is rare and adrenal crisis due to adrenal metastasis is also extremely rare. We report a case of undifferentiated carcinoma of the small intestine and adrenal crisis due to bilateral adrenal metastasis. Adrenal function tests should be done in patients with bilateral adrenal metastasis.

    DOI: 10.3919/jjsa.74.2901

    CiNii Article

  • A Case of Undifferntiated Carcinoma of Sigmoid Colon with Extraluminal Growth in which the Patient Died Shortly after Curative Operation

    SHIBUTANI Masatsune, MAEDA Kiyoshi, NAGAHARA Hisashi, NODA Eiji, OHTANI Hiroshi, OHSAWA Masahiko, HIRAKAWA Kosei

    Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association)   74 ( 5 )   1321 - 1325   2013( ISSN:13452843

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    A 69-year-old man was admitted for left lower abdominal pain computed tomography (CT) scan found a tumor of the sigmoid colon with extraluminal growth. Based on a diagnosis of malignat tumor-like gastrointestinal stromal tumor (GIST), we conducted a sigmoidectomy. Histopathological examination showed no findings suggestive of endocrine cell carcinoma, so that undifferentiated carcinoma was diagnosed. The depth of tumor invasion was SE, no lymph node metastasis were seen, and it was in stage II. He developed peritoneal metastasis after about 1 month and died of cancer 2 months after the curative operation without chemotherapy.<BR>An undifferentiated colorectal carcinoma is very rare and its prognosis is very poor. Colorectal cancer with extraluminal growth is also rare and often detected after progression because of poor symptoms.<BR>We report a case of undifferentiated carcinoma of the sigmoid colon with extraluminal growth who died only 2 months after a curative operation.

    DOI: 10.3919/jjsa.74.1321

    CiNii Article

  • Promising effects of pregabalin in the treatment of oxaliplatin-induced sensory neuropathy in patients with colorectal carcinoma Reviewed

    Hisashi Nagahara, Eiji Noda, Kiyoshi Maeda, Toru Inoue, Toshiki Hirakawa, Tsuyoshi Hasegawa, Masatsune Shibutani, Kosei Hirakawa

    Japanese Journal of Cancer and Chemotherapy   40 ( 9 )   1181 - 1183   2013( ISSN:0385-0684

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    Thirteen patients with metastatic colorectal cancer who suffered from oxaliplatin-induced sensory neuropathy were evaluated to determine the neuropathy Grade before and after the administration of pregabalin. All patients received oxaliplatin as adjuvant or first-line chemotherapy. The mFOLFOX6 and CapeOX groups included 3 and 10 cases, respectively, and the average treatment regimens were 8 and 5 doses, respectively. Before receiving pregabalin, sensory neuropathy was classified as Grade 3 in 2 patients, as Grade 2 in 8 patients, and as Grade 1 in 3 patient. The average amount of pregabalin administered to patients was 237 (range: 150-450) mg. After administering pregabalin, we observed improvements in 8 neuropathy cases (61. 5%) within approximately 2 weeks. All side effects were mild. In this study, pregabalin was shown to positively impact sensory neuropathy resulting from oxaliplatin treatment and to enable the long-term use of oxaliplatin-based chemotherapy.

    PubMed

  • A Case of Metastatic Colon Cancer Detected due to an Intra-abdominal Abscess following Surgery for Cervical Cancer

    TAUCHI Jun, NAGAHARA Hisashi, SHIBUTANI Masatune, NODA Eiji, MAEDA Kiyoshi, HIRAKAWA Kosei

    Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association)   74 ( 12 )   3405 - 3409   2013( ISSN:13452843

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    Publishing type:Research paper (scientific journal)  

    A woman 44 years old was diagnosed with stage IIb, T2bN0M0 cervical cancer following atypical genital bleeding, and she underwent radical hysterectomy and bilateral ovarian lift surgery. The patient developed right-sided abdominal pain from around seven months postoperatively, and computed tomography (CT) examination showed an intra-abdominal abscess in the right paracolic gutter, while imaging of the abscess cavity showed formation of a fistula between the abscess cavity and the ascending colon. Since no improvements were seen following abscess drainage, right hemicolectomy and peritoneal drainage were performed. A perforation was found in the ascending colon, and wall hardening was seen from the cecum to the lateral posterior side of the ascending colon, with formation of an abscess cavity. The pathological diagnosis was squamous cell carcinoma in the submucosa of the perforation site and the attachment site of the tumor on the serosal side, and the tumor contained tissues from the ovaries and the oviduct. A diagnosis of cervical cancer metastasis to the ascending colon was made. Since colonic metastasis of malignant tumors is a relatively rare condition, this case of colonic metastasis of cervical cancer is reported in the context of the relevant literature.

    DOI: 10.3919/jjsa.74.3405

    CiNii Article

  • A Case of Adrenal Crisis after Operation due to Bilateral Adrenal Metastasis of Undifferentiated Carcinoma of the Small Intestine

    SHIBUTANI Masatsune, MAEDA Kiyoshi, OHTANI Hiroshi, NAGAHARA Hisashi, NODA Eiji, SAKABE Manami, OSAWA Masahiko, HIRAKAWA Kosei

    Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association)   74 ( 10 )   2901 - 2905   2013( ISSN:13452843

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    Publishing type:Research paper (scientific journal)  

    An 81-year-old man was admitted to our hospital because of bleeding from carcinoma of the small intestine. Although an abdominal computed tomography (CT) scan showed bilateral adrenal metastasis and paraaortic lymph node metastasis, partial resection of the small intestine was performed to control the bleeding. The morning after the operation, he entered a state of shock. Adrenal insufficiency was suspected because of low blood pressure, hypoglycemia and hyperkalemia. His symptoms were dramatically improved by hydrocortisone treatment.<BR>He was diagnosed with undifferentiated carcinoma of the small intestine by histopathological and immunohistochemical examination.<BR>An undifferentiated carcinoma of the small intestine is rare and adrenal crisis due to adrenal metastasis is also extremely rare. We report a case of undifferentiated carcinoma of the small intestine and adrenal crisis due to bilateral adrenal metastasis. Adrenal function tests should be done in patients with bilateral adrenal metastasis.

    DOI: 10.3919/jjsa.74.2901

    CiNii Article

  • Six Cases of Colorectal and Small Bowel Cancer Associated with Crohn's Disease

    Takii Mamiko, Maeda Kiyoshi, Nagahara Hisashi, Noda Eiji, Shibutani Masatsune, Kamata Noriko, Mitsue Sogawa, Yamagami Hirokazu, Watanabe Kenji, Hirakawa Kousei

    Nippon Daicho Komonbyo Gakkai Zasshi   66 ( 4 )   229 - 233   2013( ISSN:00471801

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    Although the number of reports of colorectal and small bowel cancer associated with Crohn's disease (CD) has been increasing, there have been few studies on the characteristics and clinical outcomes of CD-associated cancer. We herein report six cases of colorectal and small bowel cancer associated with Crohn's disease treated from January 2001 to May 2011. Their average age was 40.0 years. All of them had been suffering from Crohn's disease for more than 10 years. There was one patient with stage I cancer, three patients with stage II, and one patient with stage IV. We were able to perform a curative resection in five cases, and disease recurrence was observed in one patient. The recent remarkable progress in medical treatments has contributed to improvements in the clinical outcome; however, careful surveillance for the occurrence of CD-associated cancer is necessary. Surveillance for the early diagnosis of neoplastic lesions can enable treatment and thus a better outcome.

    DOI: 10.3862/jcoloproctology.66.229

    CiNii Article

  • PS-018-1 大腸癌同時性腹膜播種症例の臨床病理学的検討(PS-018 大腸 腹膜播種,ポスターセッション,第112回日本外科学会定期学術集会) Reviewed

    野田 英児, 前田 清, 永原 央, 井上 透, 木村 健二郎, 天野 良亮, 渋谷 雅常, 久保 尚士, 田中 浩明, 六車 一哉, 八代 正和, 山田 靖哉, 高島 勉, 小野田 尚佳, 仲田 文造, 川尻 成美, 西口 幸男, 大平 雅一, 石川 哲郎, 池原 照幸, 平川 弘聖

    一般社団法人日本外科学会 日本外科学会雑誌   113 ( 2 )   2012.03( ISSN:03014894

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    CiNii Article

  • VD-009-5 腹腔鏡下大腸癌手術における縫合不全ゼロを目指したDST吻合法の工夫(VD-009 ビデオセッション(9)直腸 鏡視下-1,第112回日本外科学会定期学術集会) Reviewed

    永原 央, 前田 清, 野田 英児, 渋谷 雅常, 木村 健二郎, 天野 良亮, 久保 尚士, 田中 浩明, 六車 一哉, 山田 靖哉, 八代 正和, 仲田 文造, 大平 雅一, 石川 哲郎, 平川 弘聖

    一般社団法人日本外科学会 日本外科学会雑誌   113 ( 2 )   2012.03( ISSN:03014894

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  • SF-093-3 大腸癌先進部における低分化胞巣の臨床的意義(SF-093 サージカルフォーラム(93)大腸 病理,第112回日本外科学会定期学術集会) Reviewed

    渋谷 雅常, 野田 英児, 前田 清, 永原 央, 井上 透, 川尻 成美, 木村 健二郎, 天野 良亮, 久保 尚士, 田中 浩明, 六車 一哉, 山田 靖哉, 八代 正和, 小野田 尚佳, 仲田 文造, 西口 幸雄, 大平 雅一, 石川 哲郎, 平川 弘聖

    一般社団法人日本外科学会 日本外科学会雑誌   113 ( 2 )   2012.03( ISSN:03014894

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    CiNii Article

  • PS-018-1 大腸癌同時性腹膜播種症例の臨床病理学的検討(PS-018 大腸 腹膜播種,ポスターセッション,第112回日本外科学会定期学術集会)

    野田 英児, 前田 清, 永原 央, 井上 透, 木村 健二郎, 天野 良亮, 渋谷 雅常, 久保 尚士, 田中 浩明, 六車 一哉, 八代 正和, 山田 靖哉, 高島 勉, 小野田 尚佳, 仲田 文造, 川尻 成美, 西口 幸男, 大平 雅一, 石川 哲郎, 池原 照幸, 平川 弘聖

    日本外科学会雑誌   113 ( 2 )   528   2012.03( ISSN:03014894

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  • VD-009-5 腹腔鏡下大腸癌手術における縫合不全ゼロを目指したDST吻合法の工夫(VD-009 ビデオセッション(9)直腸 鏡視下-1,第112回日本外科学会定期学術集会)

    永原 央, 前田 清, 野田 英児, 渋谷 雅常, 木村 健二郎, 天野 良亮, 久保 尚士, 田中 浩明, 六車 一哉, 山田 靖哉, 八代 正和, 仲田 文造, 大平 雅一, 石川 哲郎, 平川 弘聖

    日本外科学会雑誌   113 ( 2 )   463   2012.03( ISSN:03014894

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  • VD-009-5 腹腔鏡下大腸癌手術における縫合不全ゼロを目指したDST吻合法の工夫(VD-009 ビデオセッション(9)直腸 鏡視下-1,第112回日本外科学会定期学術集会) Reviewed

    永原 央, 前田 清, 野田 英児, 渋谷 雅常, 木村 健二郎, 天野 良亮, 久保 尚士, 田中 浩明, 六車 一哉, 山田 靖哉, 八代 正和, 仲田 文造, 大平 雅一, 石川 哲郎, 平川 弘聖

    一般社団法人日本外科学会 日本外科学会雑誌   113 ( 2 )   2012.03( ISSN:0301-4894

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    Publishing type:Research paper (scientific journal)  

    CiNii Article

  • SF-093-3 大腸癌先進部における低分化胞巣の臨床的意義(SF-093 サージカルフォーラム(93)大腸 病理,第112回日本外科学会定期学術集会) Reviewed

    渋谷 雅常, 野田 英児, 前田 清, 永原 央, 井上 透, 川尻 成美, 木村 健二郎, 天野 良亮, 久保 尚士, 田中 浩明, 六車 一哉, 山田 靖哉, 八代 正和, 小野田 尚佳, 仲田 文造, 西口 幸雄, 大平 雅一, 石川 哲郎, 平川 弘聖

    一般社団法人日本外科学会 日本外科学会雑誌   113 ( 2 )   2012.03( ISSN:0301-4894

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  • SF-093-3 大腸癌先進部における低分化胞巣の臨床的意義(SF-093 サージカルフォーラム(93)大腸 病理,第112回日本外科学会定期学術集会)

    渋谷 雅常, 野田 英児, 前田 清, 永原 央, 井上 透, 川尻 成美, 木村 健二郎, 天野 良亮, 久保 尚士, 田中 浩明, 六車 一哉, 山田 靖哉, 八代 正和, 小野田 尚佳, 仲田 文造, 西口 幸雄, 大平 雅一, 石川 哲郎, 平川 弘聖

    日本外科学会雑誌   113 ( 2 )   411   2012.03( ISSN:03014894

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  • PS-018-1 大腸癌同時性腹膜播種症例の臨床病理学的検討(PS-018 大腸 腹膜播種,ポスターセッション,第112回日本外科学会定期学術集会) Reviewed

    野田 英児, 前田 清, 永原 央, 井上 透, 木村 健二郎, 天野 良亮, 渋谷 雅常, 久保 尚士, 田中 浩明, 六車 一哉, 八代 正和, 山田 靖哉, 高島 勉, 小野田 尚佳, 仲田 文造, 川尻 成美, 西口 幸男, 大平 雅一, 石川 哲郎, 池原 照幸, 平川 弘聖

    一般社団法人日本外科学会 日本外科学会雑誌   113 ( 2 )   2012.03( ISSN:0301-4894

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  • Predictive Value of Expression of ERCC 1 and GST-p for 5-Fluorouracil/Oxaliplatin Chemotheraphy in Advanced Colorectal Cancer Reviewed

    Eiji Noda, Kiyoshi Maeda, Toru Inoue, Shinya Fukunaga, Hisashi Nagahara, Masatsune Shibutani, Ryosuke Amano, Bunzo Nakata, Hiroaki Tanaka, Kazuya Muguruma, Nobuya Yamada, Masakazu Yashiro, Masaichi Ohira, Tetsuro Ishikawa, Kosei Hirakawa

    HEPATO-GASTROENTEROLOGY   59 ( 113 )   130 - 3   2012.01( ISSN:0172-6390

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    Background/Aims: The aim of this study was to determine whether expression of the excision repair cross complementing protein (ERCC1), glutathione S-transferase pi (GST-p) and thymidylate synthase (TS) predict response in patients with advanced colorectal cancer treated with 5-fluorouracil/oxaliplatin chemotherapy. Methodology: The study population consisted of 39 patients with advanced colorectal cancer (median age, 65 years). Patients were treated with the modified FOLFOX 6 regimen. The expression of ERCC-1, GST-p and TS of primary tumors were examined by immunohistochemistry. Results: The response rate of modified FOLFOX 6 chemotherapy was 51.3%. The positive rates of ERCC-1, GST-p and TS were 43.6%, 33.3% and 66.7%, respectively. The patients without ERCC-1 (p=0.0248) or GST-p (p=0.0019) expression were more likely to respond to chemotherapy. TS expression did not correlate with chemotherapeutic response. Conclusions: Immunohistochemical studies for ERCC-1 and GST-p may be useful in prediction of the response to 5-fluorouracil/oxaliplatin chemotherapy in advanced colorectal cancer patients.

    DOI: 10.5754/hge11022

    PubMed

  • Predictive Value of Expression of ERCC 1 and GST-p for 5-Fluorouracil/Oxaliplatin Chemotheraphy in Advanced Colorectal Cancer Reviewed

    Noda Eiji, Maeda Kiyoshi, Inoue Toru, Fukunaga Shinya, Nagahara Hisashi, Shibutani Masatsune, Amano Ryosuke, Nakata Bunzo, Tanaka Hiroaki, Muguruma Kazuya, Yamada Nobuya, Yashiro Masakazu, Ohira Masaichi, Ishikawa Tetsuro, Hirakawa Kosei

    HEPATO-GASTROENTEROLOGY   59 ( 113 )   130 - 133   2012( ISSN:0172-6390

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    DOI: 10.5754/hge11022

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  • [Two resected cases of extragastric gastric cancer growth with gastrocolic fistula]. Reviewed

    Kashiwagi S, Teraoka H, Ohira G, Shibutani M, Sakashita K, Kanehara I, Tamamori Y, Nitta A, Hirakawa K

    Gan to kagaku ryoho. Cancer & chemotherapy   38 ( 12 )   2125 - 7   2011.11( ISSN:0385-0684

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    PubMed

  • [Two resected cases of extragastric gastric cancer growth with gastrocolic fistula]. Reviewed

    Kashiwagi S, Teraoka H, Ohira G, Shibutani M, Sakashita K, Kanehara I, Tamamori Y, Nitta A, Hirakawa K

    Gan to kagaku ryoho. Cancer & chemotherapy   38 ( 12 )   2125 - 7   2011.11( ISSN:0385-0684

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    PubMed

  • [Two resected cases of extragastric gastric cancer growth with gastrocolic fistula].

    Kashiwagi S, Teraoka H, Ohira G, Shibutani M, Sakashita K, Kanehara I, Tamamori Y, Nitta A, Hirakawa K

    Gan to kagaku ryoho. Cancer & chemotherapy   38 ( 12 )   2125 - 7   2011.11( ISSN:0385-0684

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  • A CASE OF PHEOCHROMOCYTOMA ASSOCIATED WITH PREGNANCY Reviewed

    NAKAMURA Masanori, ONODA Naoyoshi, SHIBUTANI Masatsune, YAMAGATA Shigehito, YAMAMASU Seiichi, NISHIO Junko, TAHARA Hideki, ISHIMURA Eiji, ISHIKAWA Tetsuro, HIRAKAWA Kosei

    66 ( 4 )   945 - 949   2005.04( ISSN:13452843

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  • A CASE OF PHEOCHROMOCYTOMA ASSOCIATED WITH PREGNANCY Reviewed

    NAKAMURA Masanori, ONODA Naoyoshi, SHIBUTANI Masatsune, YAMAGATA Shigehito, YAMAMASU Seiichi, NISHIO Junko, TAHARA Hideki, ISHIMURA Eiji, ISHIKAWA Tetsuro, HIRAKAWA Kosei

    Japan Surgical Association 日本臨床外科学会雑誌   66 ( 4 )   945 - 949   2005.04( ISSN:1345-2843

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    38歳女性.平成14年4月妊婦検診にて高血圧を指摘された.精査にて左腎門部に腫瘤を認め,血中,尿中のカテコラミンが高値を示したため,褐色細胞腫と診断された.診断時妊娠23週であり,ラベタロール150mg/日,ドキサゾシン2mg/日にて血圧をコントロールできたため,妊娠28週にて待機手術を施行した.全身麻酔下に,帝王切開術を施行後,開腹下に左副腎腫瘍摘出術を施行した.術後経過は母児共に良好であった.妊娠に合併した褐色細胞腫の本邦報告例は47例に過ぎず,過去の検討では母児ともに高い死亡率を示していた.しかし,最近の症例では十分な術前管理により良好な成績が得られている.治療においては,手術時期を十分に考慮しなければならないが,降圧薬によるコントロールが良好であれば,妊娠第28週以降に一期的な手術が安全に施行し得ると考えられた.

    DOI: 10.3919/jjsa.66.945

    CiNii Article

  • A CASE OF PHEOCHROMOCYTOMA ASSOCIATED WITH PREGNANCY Reviewed

    NAKAMURA Masanori, ONODA Naoyoshi, SHIBUTANI Masatsune, YAMAGATA Shigehito, YAMAMASU Seiichi, NISHIO Junko, TAHARA Hideki, ISHIMURA Eiji, ISHIKAWA Tetsuro, HIRAKAWA Kosei

    Japan Surgical Association, The journal of the Japanese Practical Surgeon Society   66 ( 4 )   945 - 949   2005( ISSN:1345-2843

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    A 38-year-old pregnant woman was pointed out to have hypertension at examination of her first trimester. She was diagnosed as having pheochromocytoma at 23th week of gestation, based on findings of high serum and urinary catecholamine levels with a left adrenal mass demonstrated by ultrasonography and MRI. Her blood pressure was able to be controlled with daily medication of labetalol 150mg and doxazosin 2mg, and the pregnancy was maintained without any problems for both the mother and fetus. At the 28th week of gestation, a cesarean section was electively performed followed by a left partial adrenalectomy under general anesthesia. The baby had no abnormal findings and the postoperative course of the mother was uneventful. Pheochromocytoma rarely associated with pregnancy. Only 47 cases have been reported in the Japanese literature. The mortality of the mother and fetus in this condition had been reported very high. However in the recent series, no fatal cases have been reported according to the development of the diagnostic procedure and appropriate preoperative management. We suggest that a term-operation can be performed safely after the 28th week gestation, with the careful management of preoperative blood pressure with medication.

    DOI: 10.3919/jjsa.66.945

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  • 大腸癌

Charge of on-campus class subject

  • Colorectal cancer, Anal cancal cancer

    2018     Undergraduate