Updated on 2024/04/09

写真a

 
NIKI Mamiko
 
Organization
Graduate School of Medicine Department of Basic Medical Science Associate Professor
School of Medicine Department of Medical Science
Title
Associate Professor
Affiliation
Institute of Medicine

Position

  • Graduate School of Medicine Department of Basic Medical Science 

    Associate Professor  2022.04 - Now

  • School of Medicine Department of Medical Science 

    Associate Professor  2022.04 - Now

Degree

  • 歯学博士 ( Kyushu University )

Research Areas

  • Life Science / Bacteriology

Job Career (off-campus)

  • Osaka City University   Graduate School of Medicine Basic Medicine Course

    2019.10 - Now

  • Osaka City University   Graduate School of Medicine Basic Medicine Course

    2006.04 - 2019.09

  • 日本学術振興会   特別研究員(PD)

    2003.04 - 2006.03

Papers

  • A Culture Supernatant from an Actinomycete sp. Affects Biofilm Formation and Virulence Expression of Candida auris.

    Kenshi Yamane, Mamiko Niki, Taishi Tsubouchi, Tetsuya Watanabe, Kazuhisa Asai, Ken-Ichi Oinuma, Arata Sakiyama, Chaogetu Saren, Yuki Matsumoto, Koichi Makimura, Yukihiro Kaneko, Tomoya Kawaguchi

    Medical mycology journal   64 ( 1 )   7 - 17   2023

     More details

    Publishing type:Research paper (scientific journal)   International / domestic magazine:Domestic journal  

    The multidrug-resistant pathogen Candida auris is characterized by its aggregation under certain conditions, which affects its biofilm formation, drug susceptibility, and pathogenicity. Although the innate tendency to aggregate depends on the strain, the mechanism regulating C. auris aggregation remains unclear. We found that the culture supernatant from one of the 95 Actinomyces strains isolated from a deep-sea environment (IMAs2016D-66) inhibited C. auris aggregation. The cells grown in the presence of IMAs2016D-66 exhibited reduced hydrophobicity, biofilm formation, and enhanced proteolytic activity. In addition, the efflux pump activity of the fluconazole-resistant C. auris strain LSEM 3673 was stimulated by IMAs2016D-66, whereas no significant change was observed in the fluconazole-susceptible strain LSEM 0643. As the relationship between aggregative tendency and virulence in C. auris is still unclear, IMAs2016D-66 can serve as a tool for investigating regulatory mechanisms of phenotype switching and virulence expression of C. auris. Understanding of phenotype switching may help us not only to understand the pathogenicity of C. auris, but also to design new drugs that target the molecules regulating virulence factors.

    DOI: 10.3314/mmj.22-00026

    PubMed

  • Rifampicin exerts anti-mucoviscous activity against hypervirulent Klebsiella pneumoniae via binding to the RNA polymerase β subunit.

    Mitsunori Tohda, Ken-Ichi Oinuma, Arata Sakiyama, Taishi Tsubouchi, Mamiko Niki, Hiroki Namikawa, Kenshi Yamane, Koichi Yamada, Tetsuya Watanabe, Kazuhisa Asai, Hiroshi Kakeya, Yukihiro Kaneko, Tomoya Kawaguchi

    Journal of global antimicrobial resistance   32   21 - 28   2022.12

     More details

    Publishing type:Research paper (scientific journal)   International / domestic magazine:International journal  

    OBJECTIVES: In hypervirulent Klebsiella pneumoniae (hvKP), the hypermucoviscous capsule is known to be a major virulence determinant. We previously discovered that rifampicin (RFP), a bactericidal drug that binds to and inhibits the β subunit of RNA polymerase (RpoB), elicits anti-mucoviscous activity against hvKP by suppressing rmpA, a regulator of capsule production. Here, we aimed to determine whether RFP exerts this effect at sub-growth-inhibitory concentrations via its binding to RpoB. METHODS: Five spontaneous RFP-resistant mutants (R1-R5) were prepared from an hvKP clinical isolate and subjected to whole genome sequencing and mucoviscosity analyses. Subsequently, a two-step allelic exchange procedure was used to create a rpoB mutant R6 and revertants with wild-type rpoB from R1-R5 (named R1'-R5'). Transcription levels of rmpA and the capsular polysaccharide polymerase gene magA and capsule thickness of R1-R5 and R1'-R5' grown without or with RFP were evaluated by quantitative reverse transcription polymerase chain reaction and microscopic observation using India ink staining. RESULTS: R1-R5 all had non-synonymous point mutations in rpoB and were highly resistant to the bactericidal effects and anti-mucoviscous activity of RFP. While the properties of R6 were similar to those of R1-R5, the responses of R1'-R5' to RFP were identical to those of the wild type. rmpA and magA transcription levels and capsule thickness correlated well with the mucoviscosity levels. CONCLUSIONS: RFP exerts anti-mucoviscous activity by binding to RpoB. The mechanism of how this causes rmpA suppression remains to be explored.

    DOI: 10.1016/j.jgar.2022.11.018

    PubMed

  • Genomic characterization of triple-carbapenemase-producing Acinetobacter baumannii Reviewed

    Ken-Ichi Oinuma, Masato Suzuki, Arata Sakiyama, Taishi Tsubouchi, Kozo Saeki, Kanako Sato, Mamiko Niki, Koichi Yamada, Keigo Shibayama, Hiroshi Kakeya, Yukihiro Kaneko

    JAC-Antimicrobial Resistance   3 ( 4 )   dlab191   2021.12

     More details

    Publishing type:Research paper (scientific journal)   International / domestic magazine:International journal  

    <title>Abstract</title>
    <sec>
    <title>Objectives</title>
    To characterize Acinetobacter baumannii OCU_Ac16a, a clinical isolate co-harbouring three acquired carbapenemase genes, blaNDM-1, blaTMB-1, and blaOXA-58, and assess the clinical significance of so-called multiple-carbapenemase producers.


    </sec>
    <sec>
    <title>Methods</title>
    OCU_Ac16a and its close relative, OCU_Ac16b, which lacks the blaNDM-1, were isolated from sputum cultures of a patient at Osaka City University Hospital. We subjected these strains to whole-genome analysis, particularly focusing on the genetic context of each carbapenemase gene. The transmissibility and functionality of each carbapenemase gene were analysed by conjugation and transformation experiments and antimicrobial susceptibility tests.


    </sec>
    <sec>
    <title>Results</title>
    bla TMB-1 was located in a class 1 integron on the chromosome, whereas blaNDM-1 and blaOXA-58 were found on plasmids named pOCU_Ac16a_2 and pOCU_Ac16a_3, respectively. pOCU_Ac16a_2 (which exhibited highly efficient self-transmissibility) and pOCU_Ac16a_3 (which did not show transmissibility but could be introduced into another A. baumannii strain via electroporation) could both confer carbapenem resistance (MICs ≥512 and ≥32 mg/L, respectively) on the recipient strain. The functionality of blaTMB-1 was evident from the high resistance of OCU_Ac16b to ceftazidime and cefepime (MICs ≥256 and 48 mg/L, respectively), and the high resistance of OCU_Ac16a to cefiderocol (MIC 32 mg/L) could be explained by the additive effect of blaNDM-1 and blaTMB-1.


    </sec>
    <sec>
    <title>Conclusions</title>
    Our data revealed the genomic organization of OCU_Ac16a and demonstrated that all the carbapenemase genes are functional, each contributing to the extremely high broad-spectrum resistance of OCU_Ac16a to β-lactams. As multiple-carbapenemase producers can be serious health threats as drug-resistant pathogens and disseminators of carbapenemase genes, close attention should be paid to their emergence.


    </sec>

    DOI: 10.1093/jacamr/dlab191

    PubMed

  • Complete Genome Sequence of a Clinical Isolate of Acinetobacter baumannii Harboring 11 Plasmids

    Arata Sakiyama, Yuki Matsumoto, Taishi Tsubouchi, Masato Suzuki, Makoto Niki, Mamiko Niki, Ken-Ich Oinuma, Hiroshi Kakeya, Yukihiro Kaneko

    Microbiology Resource Announcements   10 ( 39 )   2021.09

     More details

    Publishing type:Research paper (scientific journal)  

    Here, we report the complete genome sequence of an
    <named-content content-type="genus-species">Acinetobacter baumannii</named-content>
    isolate harboring 11 plasmids, obtained at a hospital in Japan in 2016. The complete 4.07-Mbp genome sequence (1 chromosome and 11 plasmids) was analyzed by a combination of long-read (Flongle) and short-read (NovaSeq 6000) sequencing.

    DOI: 10.1128/mra.00695-21

  • Complete Genome Sequence of Acinetobacter pittii OCU_Ac17, Isolated from Human Venous Blood

    Yuki Matsumoto, Arata Sakiyama, Taishi Tsubouchi, Masato Suzuki, Makoto Niki, Mamiko Niki, Hiroshi Kakeya, Yukihiro Kaneko

    Microbiology Resource Announcements   10 ( 39 )   2021.09

     More details

    Publishing type:Research paper (scientific journal)  

    <named-content content-type="genus-species">Acinetobacter pittii</named-content>
    isolate OCU_Ac17 was obtained from the venous blood of a patient at a hospital in Japan. We present its complete 4.108-Mbp genome sequence (1 chromosome plus 3 plasmids), analyzed by combining long-read (Flongle) and short-read (MiniSeq) sequencing.

    DOI: 10.1128/mra.00696-21

  • Siderophore production as a biomarker for Klebsiella pneumoniae strains that cause sepsis: A pilot study.

    Hiroki Namikawa, Makoto Niki, Mamiko Niki, Ken-Ichi Oinuma, Koichi Yamada, Kiyotaka Nakaie, Taishi Tsubouchi, Yoshihiro Tochino, Yasuhiko Takemoto, Yukihiro Kaneko, Hiroshi Kakeya, Taichi Shuto

    Journal of the Formosan Medical Association = Taiwan yi zhi   121 ( 4 )   848 - 855   2021.07

     More details

    Publishing type:Research paper (scientific journal)   International / domestic magazine:International journal  

    BACKGROUND/PURPOSE: Klebsiella pneumoniae bacteremia-induced sepsis is a clinically important condition with a high mortality rate and various known virulence factors. However, studies on the association of these virulence factors with the occurrence of K. pneumoniae bacteremia-induced sepsis are scarce. We aimed to investigate clinical variables and virulence factors in patients with K. pneumoniae bacteremia-induced sepsis. METHODS: We retrospectively reviewed the medical records of 76 patients with K. pneumoniae bacteremia between January 2012 and July 2017. Patients were divided into sepsis (n = 25) and non-sepsis (n = 51) groups. Patient background characteristics, antimicrobial regimens, and prognosis were evaluated. We assessed the distribution of virulence factors related to K. pneumoniae, such as mucoviscosity, capsular polysaccharide, and siderophores. Siderophore production levels were determined by measuring the orange halo zone on chrome azurol S agar plate assay. RESULTS: There were no intergroup differences in male-to-female ratio and age. Multivariable analysis revealed that siderophore production level (p < 0.01) was an independent predictor of K. pneumoniae bacteremia-induced sepsis. Furthermore, the optimal cut-off point of siderophore production to predict sepsis was 9.6 mm (sensitivity, 86%; specificity, 76%; AUC, 0.81). CONCLUSION: Siderophore production was an independent predictor of sepsis caused by K. pneumoniae bacteremia. The optimal cut-off point for siderophore production for sepsis occurrence prediction was 9.6 mm. To improve outcomes, patients with K. pneumoniae bacteremia-induced sepsis with high siderophore production levels should be managed prudently.

    DOI: 10.1016/j.jfma.2021.06.027

    PubMed

  • Complete Genome Sequence of Acinetobacter baumannii ATCC 19606T, a Model Strain of Pathogenic Bacteria Causing Nosocomial Infection. Reviewed

    Taishi Tsubouchi, Masato Suzuki, Makoto Niki, Ken-Ichi Oinuma, Mamiko Niki, Hiroshi Kakeya, Yukihiro Kaneko

    Microbiology resource announcements   9 ( 20 )   2020.05

     More details

    Publishing type:Research paper (scientific journal)  

    Acinetobacter baumannii ATCC 19606T, which is often used in genetic studies as a routine model microorganism, belongs to sequence type 52 (ST52), showing beta-lactam resistance. We present the complete 3.996-Mbp genome sequence (1 chromosome plus 2 plasmids), generated by combining long-read (MinION) and short-read (MiniSeq) sequencing data.

    DOI: 10.1128/MRA.00289-20

    PubMed

  • Detection of Rhizopus-specific antigen in human and murine serum and bronchoalveolar lavage. Reviewed

    Wataru Shibata, Mamiko Niki, Kanako Sato, Hiroki Fujimoto, Koichi Yamada, Tetsuya Watanabe, Yoshitsugu Miyazaki, Kazuhisa Asai, Yoko Obata, Taro Tachibana, Tomoya Kawaguchi, Yukihiro Kaneko, Hiroshi Kakeya

    Medical mycology   2020.02

     More details

    Publishing type:Research paper (scientific journal)  

    Mucormycosis is a deep-seated fungal infection that mainly develops in patients with severe immunodeficiencies such as those with malignant hematological diseases. Despite poor prognosis, there is no reliable and minimally invasive diagnostic method-such as serodiagnosis-for making a clinical decision regarding the condition. As early diagnosis and early treatment improve the prognosis of mucormycosis, the development of a sensitive early diagnostic method is important. We had previously identified a Rhizopus-specific antigen (RSA) by signal sequence trapping and retrovirus-mediated expression (SST-REX), and evaluated its utility as a diagnostic antigen by constructing a sandwich enzyme-linked immunosorbent assay (ELISA) system to detect serum RSA levels in inoculated mice. In this study, we used the RSA-specific rabbit monoclonal antibodies generated by novel hybridoma technology to improve the sensitivity of the ELISA system. We observed an increase in serum and bronchoalveolar lavage fluid (BALF) levels of RSA in mouse model 1 day after inoculation, suggesting that this newly developed monoclonal antibody-based ELISA system may be useful for the diagnosis of mucormycosis in the early stages of infection. In addition, we measured RSA levels in human serum and BALF, and found that serum RSA level was higher in mucormycosis patients (15.1 ng/ml) than that in invasive pulmonary aspergillosis patients (0.53 ng/ml) and the negative control (0.49 ng/ml). Our results suggest that RSA may be a powerful tool for the diagnosis of pulmonary mucormycosis, and its differentiation from other deep-seated mycoses such as aspergillosis.

    DOI: 10.1093/mmy/myaa001

    PubMed

  • Nutritional status positively impacts humoral immunity against its Mycobacterium tuberculosis, disease progression, and vaccine development. Reviewed

    Mamiko Niki, Takashi Yoshiyama, Hideaki Nagai, Yuji Miyamoto, Makoto Niki, Ken-Ichi Oinuma, Taishi Tsubouchi, Yukihiro Kaneko, Sohkichi Matsumoto, Yuka Sasaki, Yoshihiko Hoshino

    PloS one   15 ( 8 )   e0237062   2020

     More details

    Publishing type:Research paper (scientific journal)  

    Nutritional status contributes to the regulation of immune responses against pathogens, and malnutrition has been considered as a risk factor for tuberculosis (TB). Mycobacterium tuberculosis (Mtb), the causative agent of TB, can modulate host lipid metabolism and induce lipid accumulation in macrophages, where the bacilli adopt a dormant phenotype. In addition, serum lipid components play dual roles in the regulation of and protection from Mtb infection. We analyzed the relationship between nutritional status and the humoral immune response in TB patients. We found that serum HDL levels are positively correlated with the serum IgA specific for Mtb antigens. Analysis of the relationship between serum nutritional parameters and clinical parameters in TB patients showed that serum albumin and CRP levels were negatively correlated before treatment. We also observed reduced serum LDL levels in TB patients following treatment. These findings may provide insight into the role of serum lipids in host immune responses against Mtb infection. Furthermore, improving the nutritional status may enhance vaccination efficacy.

    DOI: 10.1371/journal.pone.0237062

    PubMed

  • Clinical and virulence factors related to the 30-day mortality of Klebsiella pneumoniae bacteremia at a tertiary hospital: a case-control study Reviewed

    Namikawa Hiroki, Niki Makoto, Niki Mamiko, Yamada Koichi, Nakaie Kiyotaka, Sakiyama Arata, Oinuma Ken-Ichi, Tsubouchi Taishi, Tochino Yoshihiro, Takemoto Yasuhiko, Kaneko Yukihiro, Shuto Taichi, Kakeya Hiroshi

    EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES   38 ( 12 )   2291 - 2297   2019.10( ISSN:0934-9723

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s10096-019-03676-y

    PubMed

  • Clinical characteristics of bacteremia caused by hypermucoviscous Klebsiella pneumoniae at a tertiary hospital Reviewed

    Namikawa Hiroki, Yamada Koichi, Sakiyama Arata, Imoto Waki, Yamairi Kazushi, Shibata Wataru, Yoshii Naoko, Niki Makoto, Nakaie Kiyotaka, Oinuma Ken-Ichi, Tsubouchi Taishi, Niki Mamiko, Tochino Yoshihiro, Takemoto Yasuhiko, Kaneko Yukihiro, Shuto Taichi, Kakeya Hiroshi

    DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE   95 ( 1 )   84 - 88   2019.09( ISSN:0732-8893

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.diagmicrobio.2019.04.008

    PubMed

  • Mortality caused by extended-spectrum beta-lactamase-producing Enterobacteriaceae bacteremia; a case control study: alert to Enterobacteriaceae strains with high minimum inhibitory concentrations of piperacillin/tazobactam. Reviewed

    Namikawa H, Yamada K, Yamairi K, Shibata W, Fujimoto H, Takizawa E, Niki M, Nakaie K, Oinuma KI, Niki M, Takemoto Y, Kaneko Y, Shuto T, Kakeya H

    Diagnostic microbiology and infectious disease   94 ( 3 )   287 - 292   2019.07( ISSN:0732-8893

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.diagmicrobio.2019.01.018

    PubMed

  • Characteristic profile of antibody responses to PPD, ESAT-6, and CFP-10 of Mycobacterium tuberculosis in pulmonary tuberculosis suspected cases in Surabaya, Indonesia

    Desak Nyoman Surya Suameitria Dewi, Ni Made Mertaniasih, Soedarsono, Yuriko Ozeki, Wayan Tunas Artama, Fihiruddin, Mamiko Niki, Yoshitaka Tateishi, Manabu Ato, Sohkichi Matsumoto

    The Brazilian Journal of Infectious Diseases   23 ( 4 )   246 - 253   2019.07( ISSN:1413-8670

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.bjid.2019.07.001

  • Discovery of anti-mucoviscous activity of rifampicin and its potential as a candidate anti-virulence agent against hypervirulent Klebsiella pneumoniae. Reviewed

    Namikawa H, Oinuma KI, Sakiyama A, Tsubouchi T, Tahara YO, Yamada K, Niki M, Takemoto Y, Miyata M, Kaneko Y, Shuto T, Kakeya H

    International journal of antimicrobial agents   2019.06( ISSN:0924-8579

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.ijantimicag.2019.05.018

    PubMed

  • Genome-based epidemiological analysis of 13 Acinetobacter strains isolated from blood cultures of hospitalized patients from a university hospital in Japan. Reviewed

    Oinuma KI, Suzuki M, Nakaie K, Sato K, Saeki K, Sakiyama A, Takizawa E, Niki M, Niki M, Yamada K, Shibayama K, Kakeya H, Kaneko Y

    Japanese journal of infectious diseases   2019.02( ISSN:1344-6304

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.7883/yoken.JJID.2018.403

    PubMed

  • Successful Treatment of Intestinal Mycosis Caused by a Simultaneous Infection with Lichtheimia ramosa and Aspergillus calidoustus. Reviewed

    Kaneko Y, Oinuma KI, Terachi T, Arimura Y, Niki M, Yamada K, Kakeya H, Mizutani T

    Internal medicine (Tokyo, Japan)   57 ( 16 )   2421 - 2424   2018.08( ISSN:0918-2918

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.2169/internalmedicine.0254-17

    PubMed

  • High-density lipoprotein suppresses tumor necrosis factor alpha production by mycobacteria-infected human macrophages. Reviewed

    Inoue M, Niki M, Ozeki Y, Nagi S, Chadeka EA, Yamaguchi T, Osada-Oka M, Ono K, Oda T, Mwende F, Kaneko Y, Matsumoto M, Kaneko S, Ichinose Y, Njenga SM, Hamano S, Matsumoto S

    Scientific reports   8 ( 1 )   6736   2018.04

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41598-018-24233-1

    PubMed

  • Longitudinal Evaluation of Humoral Immunity and Bacterial and Clinical Parameters Reveals That Antigen-Specific Antibodies Suppress Inflammatory Responses in Active Tuberculosis Patients. Reviewed

    Niki M, Yoshiyama T, Miyamoto Y, Okumura M, Niki M, Oinuma KI, Kaneko Y, Matsumoto S, Sasaki Y, Ogata H, Goto H, Kudoh S, Hoshino Y

    Journal of immunology research   2018   4928757   2018( ISSN:2314-8861

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.1155/2018/4928757

    PubMed

  • Clinical Characteristics and Low Susceptibility to Daptomycin in Enterococcus faecium Bacteremia. Reviewed

    Namikawa H, Yamada K, Shibata W, Fujimoto H, Takizawa E, Niki M, Nakaie K, Nakamura Y, Oinuma KI, Niki M, Takemoto Y, Kaneko Y, Shuto T, Kakeya H

    The Tohoku journal of experimental medicine   243 ( 3 )   211 - 218   2017.11( ISSN:0040-8727

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.1620/tjem.243.211

    PubMed

  • Identification of a Novel Rhizopus-specific Antigen by Screening with a Signal Sequence Trap and Evaluation as a Possible Diagnostic Marker of Mucormycosis. Reviewed

    Sato K, Oinuma KI, Niki M, Yamagoe S, Miyazaki Y, Asai K, Yamada K, Hirata K, Kaneko Y, Kakeya H

    Medical mycology   55 ( 7 )   713 - 719   2017.10( ISSN:1369-3786

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/mmy/myw146

    PubMed

  • Effects of nutritional and ambient oxygen condition on biofilm formation in Mycobacterium avium subsp. hominissuis via altered glycolipid expression. Reviewed

    Totani T, Nishiuchi Y, Tateishi Y, Yoshida Y, Kitanaka H, Niki M, Kaneko Y, Matsumoto S

    Scientific reports   7   41775   2017.02

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/srep41775

    PubMed

  • Genome Sequence of an Acinetobacter baumannii Strain Carrying Three Acquired Carbapenemase Genes. Reviewed

    Oinuma KI, Suzuki M, Sato K, Nakaie K, Niki M, Takizawa E, Niki M, Shibayama K, Yamada K, Kakeya H, Kaneko Y

    Genome announcements   4 ( 6 )   2016.11

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.1128/genomeA.01290-16

    PubMed

  • An Intrinsic Strain of Colistin-resistant Acinetobacter Isolated from a Japanese Patient. Reviewed

    Takizawa E, Yamada K, Oinuma K, Sato K, Niki M, Namikawa H, Fujimoto H, Asai K, Kaneko Y, Kakeya H

    Internal medicine (Tokyo, Japan)   55 ( 16 )   2301 - 2306   2016( ISSN:0918-2918

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.2169/internalmedicine.55.6807

    PubMed

  • A New Screen for Tuberculosis Drug Candidates Utilizing a Luciferase-Expressing Recombinant Mycobacterium bovis Bacillus Calmette-Guéren. Reviewed

    Ozeki Y, Igarashi M, Doe M, Tamaru A, Kinoshita N, Ogura Y, Iwamoto T, Sawa R, Umekita M, Enany S, Nishiuchi Y, Osada-Oka M, Hayashi T, Niki M, Tateishi Y, Hatano M, Matsumoto S

    PloS one   10 ( 11 )   e0141658   2015

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.1371/journal.pone.0141658

    PubMed

  • Proteome analysis identifies the Dpr protein of Streptococcus mutans as an important factor in the presence of early streptococcal colonizers of tooth surfaces. Reviewed

    Yoshida A, Niki M, Yamamoto Y, Yasunaga A, Ansai T

    PloS one   10 ( 3 )   e0121176   2015

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.1371/journal.pone.0121176

    PubMed

  • Evaluation of Humoral Immunity to Mycobacterium tuberculosis-Specific Antigens for Correlation with Clinical Status and Effective Vaccine Development. Reviewed

    Niki M, Suzukawa M, Akashi S, Nagai H, Ohta K, Inoue M, Niki M, Kaneko Y, Morimoto K, Kurashima A, Kitada S, Matsumoto S, Suzuki K, Hoshino Y

    Journal of immunology research   2015   527395   2015( ISSN:2314-8861

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.1155/2015/527395

    PubMed

  • Potent drugs that attenuate anti-Candida albicans activity of fluconazole and their possible mechanisms of action. Reviewed

    Urai M, Kaneko Y, Niki M, Inoue M, Tanabe K, Umeyama T, Fukazawa H, Ohno H, Miyazaki Y

    Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy   20 ( 10 )   612 - 615   2014.10( ISSN:1341-321X

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.jiac.2014.06.004

    PubMed

  • Direct detection of Mycobacterium avium in environmental water and scale samples by loop-mediated isothermal amplification. Reviewed

    Nishiuchi Y, Tamaru A, Suzuki Y, Kitada S, Maekura R, Tateishi Y, Niki M, Ogura H, Matsumoto S

    Journal of water and health   12 ( 2 )   211 - 219   2014.06( ISSN:1477-8920

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.2166/wh.2013.007

    PubMed

  • Case of trichomycosis axillaris caused by Corynebacterium propinquum. Reviewed

    Kimura Y, Nakagawa K, Imanishi H, Ozawa T, Tsuruta D, Niki M, Ezaki T

    The Journal of dermatology   41 ( 5 )   467 - 469   2014.05( ISSN:0385-2407

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/1346-8138.12468

    PubMed

  • Serological surveillance development for tropical infectious diseases using simultaneous microsphere-based multiplex assays and finite mixture models. Reviewed

    Fujii Y, Kaneko S, Nzou SM, Mwau M, Njenga SM, Tanigawa C, Kimotho J, Mwangi AW, Kiche I, Matsumoto S, Niki M, Osada-Oka M, Ichinose Y, Inoue M, Itoh M, Tachibana H, Ishii K, Tsuboi T, Yoshida LM, Mondal D, Haque R, Hamano S, Changoma M, Hoshi T, Kamo K, Karama M, Miura M, Hirayama K

    PLoS neglected tropical diseases   8 ( 7 )   e3040   2014( ISSN:1935-2727

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.1371/journal.pntd.0003040

    PubMed

  • T cell and B cell immunological responses by tuberculous antigens in Japanese populations with different bacterial antigen expressions Reviewed

    Sakakibara Yumi, Niki Mamiko, Sakagami Takuro, Ariga Haruyuki, Matsumoto Sohkichi, Inase Naohiko, Nagai Hideaki, Reche Pedro A, Hoshino Yoshihiko

    EUROPEAN RESPIRATORY JOURNAL   42   2013.09( ISSN:0903-1936

     More details

    Publishing type:Research paper (scientific journal)  

  • Whole-Genome Sequence of the Potentially Hypertransmissible Multidrug-Resistant Mycobacterium tuberculosis Beijing Strain OM-V02_005. Reviewed

    Tateishi Y, Tamaru A, Ogura Y, Niki M, Wada T, Yamamoto T, Hirata K, Hayashi T, Matsumoto S

    Genome announcements   1 ( 4 )   2013.08

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.1128/genomeA.00608-13

    PubMed

  • Antigen 85A and mycobacterial DNA-binding protein 1 are targets of immunoglobulin G in individuals with past tuberculosis. Reviewed

    Osada-Oka M, Tateishi Y, Hirayama Y, Ozeki Y, Niki M, Kitada S, Maekura R, Tsujimura K, Koide Y, Ohara N, Yamamoto T, Kobayashi K, Matsumoto S

    Microbiology and immunology   57 ( 1 )   30 - 37   2013.01( ISSN:0385-5600

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/j.1348-0421.2012.12005.x

    PubMed

  • Whole-genome sequence of the hypervirulent clinical strain Mycobacterium intracellulare M.i.198. Reviewed

    Tateishi Y, Kitada S, Miki K, Maekura R, Ogura Y, Ozeki Y, Nishiuchi Y, Niki M, Hayashi T, Hirata K, Kobayashi K, Matsumoto S

    Journal of bacteriology   194 ( 22 )   6336   2012.11( ISSN:0021-9193

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.1128/JB.01439-12

    PubMed

  • A novel mechanism of growth phase-dependent tolerance to isoniazid in mycobacteria. Reviewed

    Niki M, Niki M, Tateishi Y, Ozeki Y, Kirikae T, Lewin A, Inoue Y, Matsumoto M, Dahl JL, Ogura H, Kobayashi K, Matsumoto S

    The Journal of biological chemistry   287 ( 33 )   27743 - 27752   2012.08( ISSN:0021-9258

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.1074/jbc.M111.333385

    PubMed

  • Hydrogen Sulfide: Sources, Detection and Health Hazards; Oral disease and hydrogen sulfide production by oral bacteria. Reviewed

    Yoshida A, Niki M, Ansai T, Nakayama K

    Advances in Medicine and Biology   57   131 - 145   2012

     More details

    Publishing type:Research paper (scientific journal)  

  • Lipid phenotype of two distinct subpopulations of Mycobacterium bovis Bacillus Calmette-Guerin Tokyo 172 substrain. Reviewed

    Naka T, Maeda S, Niki M, Ohara N, Yamamoto S, Yano I, Maeyama J, Ogura H, Kobayashi K, Fujiwara N

    The Journal of biological chemistry   286 ( 51 )   44153 - 44161   2011.12( ISSN:0021-9258

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.1074/jbc.M111.310037

    PubMed

  • Structure and host recognition of serotype 13 glycopeptidolipid from Mycobacterium intracellulare. Reviewed

    Naka T, Nakata N, Maeda S, Yamamoto R, Doe M, Mizuno S, Niki M, Kobayashi K, Ogura H, Makino M, Fujiwara N

    Journal of bacteriology   193 ( 20 )   5766 - 5774   2011.10( ISSN:0021-9193

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.1128/JB.05412-11

    PubMed

  • Changes in salivary antimicrobial peptides, immunoglobulin A and cortisol after prolonged strenuous exercise. Reviewed

    Usui T, Yoshikawa T, Orita K, Ueda SY, Katsura Y, Fujimoto S, Yoshimura M

    European journal of applied physiology   111 ( 9 )   2005 - 2014   2011.09( ISSN:1439-6319

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00421-011-1830-6

    PubMed

  • Effects of non-iron metalloporphyrins on growth and gene expression of Porphyromonas gingivalis. Reviewed

    Yukitake H, Naito M, Sato K, Shoji M, Ohara N, Yoshimura M, Sakai E, Nakayama K

    Microbiology and immunology   55 ( 3 )   141 - 53   2011.03( ISSN:0385-5600

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/j.1348-0421.2010.00299.x

    PubMed

  • Porphyromonas gingivalisの増殖と遺伝子発現に対する非鉄メタロポルフィリンの作用(Effects of non-iron metalloporphyrins on growth and gene expression of Porphyromonas gingivalis) Reviewed

    Yukitake Hideharu, Naito Mariko, Sato Keiko, Shoji Mikio, Ohara Naoya, Yoshimura Mamiko, Sakai Eiko, Nakayama Koji

    John Wiley & Sons Australia, Ltd Microbiology and Immunology   55 ( 3 )   141 - 153   2011.03( ISSN:0385-5600

     More details

    Publishing type:Research paper (scientific journal)  

    慢性歯周炎の病原菌P.gingivalisは増殖するためにはヘムが必要なので、非鉄メタロポルフィリンIn-PPIXとGa-PPIXの抗菌効果を検討した。In-PPIXとGa-PPIXは用量依存性にP.gingivalisの増殖を遅延させた。マイクロアレイおよびqPCR分析により、In-PPIX処理は、C1pファミリーに属するC1pBとC1pC、aRNR、aRNR活性化蛋白質とチオレドキシンレダクターゼを含む蛋白質をコードする遺伝子発現を上方制御することが分かった。しかし、In-PPIX処理ではヘム取り込み経路であるHmu介在性、Iht介在性、Tlr介在性経路に関与する蛋白質をコードする遺伝子発現には影響を与えなかった。P.gingivalisのihtAとihtB変異株は野生株よりもIn-PPIXに抵抗性を示したが、hmuRとtlr変異株は抵抗性を示さなかった。In-PPIXはIht介在性ヘム取り込み経路によってP.gingivalisに取り込まれ、蛋白質品質管理とヌクレオチド代謝に影響を与え、増殖を遅らせることが示唆された。

  • A histone-like protein of mycobacteria possesses ferritin superfamily protein-like activity and protects against DNA damage by Fenton reaction. Reviewed

    Takatsuka M, Osada-Oka M, Satoh EF, Kitadokoro K, Nishiuchi Y, Niki M, Inoue M, Iwai K, Arakawa T, Shimoji Y, Ogura H, Kobayashi K, Rambukkana A, Matsumoto S

    PloS one   6 ( 6 )   e20985   2011

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.1371/journal.pone.0020985

    PubMed

  • Tetratricopeptide repeat protein-associated proteins contribute to the virulence of Porphyromonas gingivalis. Reviewed

    Kondo Y, Ohara N, Sato K, Yoshimura M, Yukitake H, Naito M, Fujiwara T, Nakayama K

    Infection and immunity   78 ( 6 )   2846 - 2856   2010.06( ISSN:0019-9567

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.1128/IAI.01448-09

    PubMed

  • Hydrogen sulfide production from cysteine and homocysteine by periodontal and oral bacteria. Reviewed

    Yoshida A, Yoshimura M, Ohara N, Yoshimura S, Nagashima S, Takehara T, Nakayama K

    Journal of periodontology   80 ( 11 )   1845 - 1851   2009.11( ISSN:0022-3492

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.1902/jop.2009.090012

    PubMed

  • Mycobacteria exploit host hyaluronan for efficient extracellular replication. Reviewed

    Hirayama Y, Yoshimura M, Ozeki Y, Sugawara I, Udagawa T, Mizuno S, Itano N, Kimata K, Tamaru A, Ogura H, Kobayashi K, Matsumoto S

    PLoS pathogens   5 ( 10 )   e1000643   2009.10( ISSN:1553-7366

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.1371/journal.ppat.1000643

    PubMed

  • Mycobacterium avium Complex Organisms Predominantly Colonize in the Bathtub Inlets of Patients' Bathrooms Reviewed

    Nishiuchi Yukiko, Tamaru Aki, Kitada Seigo, Taguri Takahiro, Matsumoto Sohkichi, Tateishi Yoshitaka, Yoshimura Mamiko, Ozeki Yuriko, Matsumura Narumi, Ogura Hisashi, Maekura Ryoji

    JAPANESE JOURNAL OF INFECTIOUS DISEASES   62 ( 3 )   182 - 186   2009.05( ISSN:1344-6304

     More details

    Publishing type:Research paper (scientific journal)  

  • Mycobacterium avium complex organisms predominantly colonize in the bathtub inlets of patients' bathrooms. Reviewed

    Nishiuchi Y, Tamura A, Kitada S, Taguri T, Matsumoto S, Tateishi Y, Yoshimura M, Ozeki Y, Matsumura N, Ogura H, Maekura R

    Japanese journal of infectious diseases   62 ( 3 )   182 - 6   2009.05( ISSN:1344-6304

     More details

    Publishing type:Research paper (scientific journal)  

    PubMed

  • Virulence of Mycobacterium avium complex strains isolated from immunocompetent patients. Reviewed

    Tateishi Y, Hirayama Y, Ozeki Y, Nishiuchi Y, Yoshimura M, Kang J, Shibata A, Hirata K, Kitada S, Maekura R, Ogura H, Kobayashi K, Matsumoto S

    Microbial pathogenesis   46 ( 1 )   6 - 12   2009.01( ISSN:0882-4010

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.micpath.2008.10.007

    PubMed

  • Control of cell wall assembly by a histone-like protein in Mycobacteria. Reviewed

    Katsube T, Matsumoto S, Takatsuka M, Okuyama M, Ozeki Y, Naito M, Nishiuchi Y, Fujiwara N, Yoshimura M, Tsuboi T, Torii M, Oshitani N, Arakawa T, Kobayashi K

    Journal of bacteriology   189 ( 22 )   8241 - 8249   2007.11( ISSN:0021-9193

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.1128/JB.00550-07

    PubMed

  • The hemoglobin receptor protein of porphyromonas gingivalis inhibits receptor activator NF-kappaB ligand-induced osteoclastogenesis from bone marrow macrophages. Reviewed

    Fujimura Y, Hotokezaka H, Ohara N, Naito M, Sakai E, Yoshimura M, Narita Y, Kitaura H, Yoshida N, Nakayama K

    Infection and immunity   74 ( 5 )   2544 - 51   2006.05( ISSN:0019-9567

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.1128/IAI.74.5.2544-2551.2006

    PubMed

  • Homogeneous enzymatic assay for L-cysteine with betaC-S lyase. Reviewed

    Nishiya Y, Yoshida Y, Yoshimura M, Fukamachi H, Nakano Y

    Bioscience, biotechnology, and biochemistry   69 ( 11 )   2244 - 6   2005.11( ISSN:0916-8451

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.1271/bbb.69.2244

    PubMed

  • Novel stationary-phase-upregulated protein of Porphyromonas gingivalis influences production of superoxide dismutase, thiol peroxidase and thioredoxin. Reviewed

    Kikuchi Y, Ohara N, Sato K, Yoshimura M, Yukitake H, Sakai E, Shoji M, Naito M, Nakayama K

    Microbiology (Reading, England)   151 ( Pt 3 )   841 - 53   2005.03( ISSN:1350-0872

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.1099/mic.0.27589-0

    PubMed

▼display all

Books and Other Publications

  • 医学部生のために作った細菌学講義

    金子 幸弘, 仁木 満美子, 老沼 研一( Role: Sole author)

    大阪市立大学大学院医学研究科細菌学  2016 

     More details

    Book type:Scholarly book

    CiNii Books

  • BCG-Vaccine and Adjuvant

    仁木 満美子( Role: Joint author ,  p215-238)

    2011.09 

MISC

  • Acinetobacter baumannii OCU_Ac16aが保持するblaTMB-1とblaOXA-58の機能性の検討

    榮山 新, 老沼 研一, 鈴木 仁人, 佐伯 康匠, 坪内 泰志, 仁木 満美子, 山田 康一, 柴山 恵吾, 掛屋 弘, 金子 幸弘

    緑膿菌感染症研究会講演記録   55回   18 - 19   2021.09( ISSN:1340-6477

  • 【高齢者の肺炎-日常診療に役立つ最新知見-】診断 肺炎原因菌の迅速診断法の有効活用 Reviewed

    仁木 満美子, 仁木 誠, 金子 幸弘

    (株)日本臨床社 日本臨床   78 ( 4 )   601 - 608   2020.04( ISSN:0047-1852

     More details

    Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 嫌気性菌研究の最前線 真菌のバイオフィルム形成における嫌気性菌の役割

    仁木 満美子, 山入 和志, 老沼 研一, 坪内 泰志, 掛屋 弘, 金子 幸弘

    日本嫌気性菌感染症学会雑誌   50 ( 1 )   23 - 23   2020.03( ISSN:2188-7365

  • 結核菌感染における液性免疫の役割

    仁木 満美子, 星野 仁彦, 仁木 誠, 老沼 研一, 金子 幸弘

    感染症学雑誌   92 ( 2 )   287 - 287   2018.03( ISSN:0387-5911

  • 結核菌感染における液性免疫の役割

    仁木満美子, 仁木満美子, 星野仁彦, 仁木誠, 仁木誠, 老沼研一, 老沼研一, 金子幸弘, 金子幸弘

    日本化学療法学会西日本支部総会プログラム・講演抄録   65th   362   2017.09

     More details

  • 【感染症診断の新たなツール】 遺伝子検査の応用 腸管感染症における遺伝子検査の応用 Reviewed

    仁木 誠, 仁木 満美子, 金子 幸弘

    (株)医薬ジャーナル社 化学療法の領域   31 ( 増刊 )   1113 - 1122   2015.04( ISSN:0913-2384

     More details

    Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

    腸管感染症の診断法として現在用いられている培養法およびイムノクロマト法には、分離培養が困難もしくは培養に長時間を有する、感度や特異度が不十分である、作業が繁雑であるなどの多くの問題点があり、治療は一般に、臨床情報から推定し、原因菌を特定する前に開始せざるを得ないのが現状である。本稿では、感度・特異度に優れ、かつ迅速な診断が可能である遺伝子検査に着目し、特に近年開発された複数標的遺伝子を同時に検出することが可能であるマルチプレックスPCR(ポリメラーゼ連鎖反応)法について、世界における腸管感染症診断キットの開発の現状と、将来的なわが国での臨床応用への展望について述べる。(著者抄録)

  • ケニア共和国Mbita地区の児童における結核菌感染と鉤虫感染の関連 Reviewed

    井上学, 岡真優子, 仁木満美子, 尾関百合子, 一ノ瀬休生, 濱野真二郎, 松本壮吉

    日本熱帯医学会大会プログラム抄録集   54th   129 - 130   2013.09

     More details

    Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

    J-GLOBAL

  • 私達の研究 鉄代謝およびイソニアジド耐性にかかわる結核菌分子の機能と治療法開発の可能性 Reviewed

    仁木 満美子, 松本 壮吉

    (株)医薬ジャーナル社 化学療法の領域   29 ( 2 )   301 - 306   2013.01( ISSN:0913-2384

     More details

    Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

    結核菌は宿主に感染後、休眠状態で長期間、潜伏感染することが知られている。また、これらの潜伏感染菌は抗菌薬に対する抵抗性を有しており、結核治療を困難にしている。筆者らは、定常期以降の結核菌体内に大量に発現する分子である抗酸菌特異的ヒストン様タンパク質Mycobacterial DNA-binding protein 1(MDP1)は生体にとって必須の元素である鉄の貯蔵および解毒に関与することで宿主内での長期生存に寄与するのみならず、抗結核薬であるイソニアジド(INH)の活性化酵素の発現を抑制することにより定常期以降にみられる結核菌のINH抵抗性の獲得に関与することを明らかにしている。本稿では、この分子をターゲットとした結核治療法開発の可能性について述べる。(著者抄録)

  • 私達の研究 鉄代謝およびイソニアジド耐性にかかわる結核菌分子の機能と治療法開発の可能性

    仁木 満美子, 松本 壮吉

    化学療法の領域   29 ( 2 )   301 - 306   2013.01( ISSN:0913-2384

     More details

    結核菌は宿主に感染後、休眠状態で長期間、潜伏感染することが知られている。また、これらの潜伏感染菌は抗菌薬に対する抵抗性を有しており、結核治療を困難にしている。筆者らは、定常期以降の結核菌体内に大量に発現する分子である抗酸菌特異的ヒストン様タンパク質Mycobacterial DNA-binding protein 1(MDP1)は生体にとって必須の元素である鉄の貯蔵および解毒に関与することで宿主内での長期生存に寄与するのみならず、抗結核薬であるイソニアジド(INH)の活性化酵素の発現を抑制することにより定常期以降にみられる結核菌のINH抵抗性の獲得に関与することを明らかにしている。本稿では、この分子をターゲットとした結核治療法開発の可能性について述べる。(著者抄録)

  • 国際共同基盤研究に応用する抗酸菌感染症研究の整備 結核病態に関する分子生物学的研究 Reviewed

    松本壮吉, 井上学, 仁木満美子, 濱野真二郎, 嶋田雅曉, 一瀬休生, 凪幸世, 岡真優子, 尾関百合子, 岡部真裕子, 小林和夫, 野内英樹, 原田登之

    国際共同基盤研究に応用する抗酸菌感染症研究の整備 平成24年度 総括・分担研究報告書   83 - 87   2013

     More details

    Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

    J-GLOBAL

  • 潜在性抗酸菌感染症の病態機構の解明及び診断・治療・予防に関する研究 潜在性結核の成立を担う菌と宿主双方の分子とその機能解明 Reviewed

    松本壮吉, 井上学, 仁木満美子, 濱野真二郎, 嶋田雅暁, 一瀬休生, 凪幸世, 岡真優子, 尾関百合子, 岡部真裕子, 小林和夫

    潜在性抗酸菌感染症の病態機構の解明及び診断・治療・予防に関する研究 平成24年度 総括・分担研究報告書   15 - 19   2013

     More details

    Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

    J-GLOBAL

  • ケニア共和国における,学生の潜在性結核菌感染と様々な寄生虫感染 Reviewed

    井上学, 岡真優子, 仁木満美子, 尾関百合子, 小野賢司, 松本真, 凪幸世, KALENDA Yombo, Dan Justin, 濱野真二郎, 一瀬休生, 小林和夫, 松本壮吉

    日本熱帯医学会大会プログラム抄録集   53rd   83   2012.09

     More details

    Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

    J-GLOBAL

  • 結核研究の新たな展開 潜在性結核と結核菌 休眠現象の分子メカニズム Reviewed

    仁木 満美子, 仁木 誠, 尾関 百合子, 岡 真優子, 松本 壮吉

    (株)最新医学社 最新医学   66 ( 3 )   511 - 517   2011.03( ISSN:0370-8241

     More details

    Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

    結核は,年間180万人の命を奪う最大級の細菌感染症である.結核菌はヒトの寄生菌であり,中間宿主は存在しないことから,活動性結核に加え,病原体の源泉である潜在性結核の対処が疾患のコントロールに重要である.潜在期において結核菌は休眠しており,現行の薬剤に抵抗性である.休眠は,結核菌の長期間生存を保証する高次生命現象である.休眠のメカニズムを明らかにすることが,結核の抜本的対策に寄与すると考えられる.(著者抄録)

  • 結核研究の新たな展開 潜在性結核と結核菌 休眠現象の分子メカニズム

    仁木 満美子, 仁木 誠, 尾関 百合子, 岡 真優子, 松本 壮吉

    最新医学   66 ( 3 )   511 - 517   2011.03( ISSN:0370-8241

     More details

    結核は,年間180万人の命を奪う最大級の細菌感染症である.結核菌はヒトの寄生菌であり,中間宿主は存在しないことから,活動性結核に加え,病原体の源泉である潜在性結核の対処が疾患のコントロールに重要である.潜在期において結核菌は休眠しており,現行の薬剤に抵抗性である.休眠は,結核菌の長期間生存を保証する高次生命現象である.休眠のメカニズムを明らかにすることが,結核の抜本的対策に寄与すると考えられる.(著者抄録)

  • 結核研究の新たな展開:潜在性結核と結核菌—休眠現象の分子メカニズム

    仁木 満美子, 尾関 百合子, 岡 真優子, 松本 壮吉

    最新医学   66 ( 3 )   2011

▼display all

Presentations

▼display all

Industrial Property Rights

  • 口腔細菌の迅速検出法の開発

     More details

    property_type:Patent 

    Application no:4792585 

  • ホモシステインの測定方法及び測定用試薬

     More details

    property_type:Patent 

    Application no:4288334 

Grant-in-Aid for Scientific Research

  • 薬剤耐性アシネトバクター属細菌を打ち砕く深海性放線菌由来活性物質の創製

    Grant-in-Aid for Challenging Research (Pioneering)/(Exploratory)  2023

  • 深海性放線菌が生産する天然物に着目したスキルス胃癌を特異的に排除する抗癌剤の開発

    Grant-in-Aid for Scientific Research(B)  2023

  • 深海放線菌由来の新規抗Candida auris物質の特性解析

    Grant-in-Aid for Scientific Research(C)  2023

  • 偏性嫌気性菌-真菌共存下における病原因子発現調節の解析

    Grant-in-Aid for Scientific Research(C)  2023

  • 偏性嫌気性菌-真菌共存下における病原因子発現調節の解析

    Grant-in-Aid for Scientific Research(C)  2022

  • 深海放線菌由来の新規抗Candida auris物質の特性解析

    Grant-in-Aid for Scientific Research(C)  2021.04

  • 深海性放線菌が生産する天然物に着目したスキルス胃癌を特異的に排除する抗癌剤の開発

    Grant-in-Aid for Scientific Research(B)  2021.04

  • 偏性嫌気性菌-真菌共存下における病原因子発現調節の解析

    Grant-in-Aid for Scientific Research(C)  2021.04

  • 薬剤耐性アシネトバクター属細菌を打ち砕く深海性放線菌由来活性物質の創製

    Grant-in-Aid for Challenging Research (Pioneering)/(Exploratory)  2021.04

  • Molecular epidemiology of drug-resistant Acinetobacter

    Grant-in-Aid for Scientific Research(C)  2017.04

  • 液性免疫誘導型新規抗結核ワクチンの開発

    Grant-in-Aid for Scientific Research(C)  2016.04

  • 潜在性結核対策を想定した、抗酸菌の長期生存を可能にする分子メカニズムの解明

    Grant-in-Aid for Scientific Research on Priority Areas  2009

  • Screening and Identification of anti-mycobacterial compounds from polyphenols.

    Grant-in-Aid for Scientific Research(C)  2009

  • Molecular mechanism of drug tolerance in dormant mycobacteria and identification of the drug target

    Grant-in-Aid for Scientific Research(C)  2009

  • Mechanism of mycobacterial growth using host hyaluronan and novel antitubercular drug development targeting mycobacterial hyaluronidase.

    Grant-in-Aid for Young Scientists(B)  2009

▼display all

Outline of education staff

  • M3細菌・真菌コースにおいて「腸内細菌科とビブリオ科」「芽胞形成菌と嫌気性菌」「抗酸菌感染症」を担当
    同コースにおいて細菌学実習を担当

Charge of on-campus class subject

  • 細菌学

    2023     Undergraduate

Charge of off-campus class subject

  • 生化学実習

    2017
    -
    Now
    Institution:Tezukayama University

     More details

    Level:Undergraduate (specialized)