Updated on 2023/05/22

写真a

 
ICHIMURA Tomoyuki
 
Organization
Graduate School of Medicine Department of Clinical Medical Science Associate Professor
School of Medicine Department of Medical Science
Title
Associate Professor
Affiliation
Institute of Medicine

Position

  • Graduate School of Medicine Department of Clinical Medical Science 

    Associate Professor  2022.04 - Now

  • School of Medicine Department of Medical Science 

    Associate Professor  2022.04 - Now

Degree

  • 医学博士 ( Osaka City University )

Research Areas

  • Life Science / Obstetrics and gynecology

  • Life Science / Human pathology

  • Life Science / Obstetrics and gynecology

  • Life Science / Obstetrics and gynecology

  • Life Science / Human pathology

  • Life Science / Human pathology

▼display all

Research Interests

  • Gynecologic oncology, gynecologic pathology, uterine fibroids, minimally invasive surgery

  • Gynecologic oncology, gynecologic pathology, uterine fibroids, minimally invasive surgery

Research subject summary

  • 子宮肉腫の経子宮頚管的針生検による診断を、これまでの形態学的方法のほか分子生物学的な検討を加えることでその診断精度を高める。

Research Career

  • Diagnosis of uterine sarcoma in needle biopsy specimens.

    uterine sarcoma, needle biopsy  Individual

    1995.04 - Now 

Professional Memberships

  • JAPAN SOCIETY OF OBSTETRICS AND GYNECOLOGY

      Domestic

  • 日本婦人科腫瘍学会

      Domestic

  • 日本産婦人科手術学会

      Domestic

  • 日本癌治療学会

      Domestic

  • 日本産科婦人科内視鏡学会

      Domestic

  • 日本臨床細胞学会

      Domestic

  • 日本婦人科腫瘍学会

  • 日本臨床細胞学会

  • 日本臨床細胞学会

  • 日本癌治療学会

  • 日本癌治療学会

  • 日本産科婦人科学会

  • JAPAN SOCIETY OF OBSTETRICS AND GYNECOLOGY

  • 日本産科婦人科内視鏡学会

  • 日本産科婦人科内視鏡学会

  • 日本産婦人科手術学会

  • 日本産婦人科手術学会

  • 日本婦人科腫瘍学会

▼display all

Job Career (off-campus)

  • Osaka Metropolitan University School of Medicine Department of Medical Science

    2022.04 - Now

  • 大阪市立大学大学院医学研究科   女性病態医学講座   医局長

    2018.04 - Now

  • Osaka City University   Graduate School of Medicine Clinical Medicine Course

    2003.04 - Now

Education

  • Osaka City University   Doctor's Course   Graduated/Completed

    - 1999

  • Osaka City University     Graduated/Completed

    - 1993

Papers

  • Correlation between the growth of uterine leiomyomata and estrogen and progesterone receptor content in needle biopsy specimens.

    Fertil Steril.   70 ( 5 )   967 - 971   1998

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    Publishing type:Research paper (scientific journal)  

  • Carcinomatous meningitis from ovarian serous carcinoma: A case report.

    Uchikura E, Fukuda T, Imai K, Yamauchi M, Kasai M, Ichimura T, Yasui T, Kuwae Y, Sumi T

    Oncology letters   25 ( 2 )   66   2023.02( ISSN:1792-1074

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  • The efficacy of human papillomavirus vaccination in young Japanese girls: the interim results of the OCEAN study.

    Hiramatsu K, Ueda Y, Yagi A, Morimoto A, Egawa-Takata T, Nakagawa S, Kobayashi E, Kimura T, Kimura T, Minekawa R, Hori Y, Sato K, Morii E, Nakayama T, Tanaka Y, Terai Y, Ohmichi M, Ichimura T, Sumi T, Murata H, Okada H, Nakai H, Matsumura N, Mandai M, Saito J, Horikoshi Y, Takagi T, Enomoto T, Shimura K

    Human vaccines & immunotherapeutics   18 ( 1 )   1951098   2022.12( ISSN:2164-5515

  • 当科における進行卵巣癌に対するベバシズマブによる維持療法の有効性と安全性

    中島 安紗海, 福田 武史, 柴田 悟, 粟津 祐一朗, 南野 成則, 末包 智紀, 今井 健至, 山内 真, 笠井 真理, 市村 友季, 安井 智代, 角 俊幸

    産婦人科の進歩   74 ( 4 )   509 - 514   2022.10( ISSN:0370-8446

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    2014年4月1日から2020年12月31日までにベバシズマブを投与した卵巣癌、腹膜癌、卵管癌患者計71例(Bev投与群)とベバシズマブを使用していない時期(2008年1月1日から2014年3月31日まで)に治療した76例(Bev非投与群)を対象に、治療効果、予後および有害事象をBev投与群(TC+Bev群)とBev非投与群(TC群)で比較した。対象はTC+Bev群71例、TC群76例で、患者背景に有意差はなかった。最良効果判定では、奏効率および病勢制御率でTC+Bev群で有意に良好であった。無病再発期間では、全観察期間において有意差はなかったが、Bevによる維持療法中は、TC+Bev群で有意に良好であった。全生存期間については、全観察期間および維持療法期間で有意差はなかった。Grade3以上の有害事象の発症率は両群間で有意差はなかった。TC+Bev群におけるベバシズマブに特徴的な有害事象は、尿蛋白5例、高血圧8例、消化管穿孔3例などを認めた。これらの有害事象でベバシズマブ投与を中止した患者は71例中9例であった。

  • Oncologic outcomes in elderly patients who underwent hysterectomy for endometrial cancer: a multi-institutional survey in Kinki District, Japan.

    Tanaka T, Yamashita S, Kuroboshi H, Kamibayashi J, Sugiura A, Yoriki K, Mori T, Tanaka K, Nagashima A, Maeda M, Kamiura S, Mizuno Y, Ohtake N, Ichimura T, Kikuchi T, Nobuta Y, Amano T, Matsumura N, Nakai H, Kobayashi E, Kamei Y, Ukita M, Hamanishi J, Hirayama J, Mabuchi Y, Kato S, Fujita H, Kiyota A, Koyama S, Fukui Y, Kimura M, Takahashi R, Terai Y, Suruga M, Kawanishi M, Nishioka K, Ohmichi M

    International journal of clinical oncology   27 ( 6 )   1084 - 1092   2022.06( ISSN:1341-9625

  • 子宮内膜癌に対する子宮摘出術を受けた高齢患者の腫瘍学的転帰 近畿地区における多施設調査(Oncologic outcomes in elderly patients who underwent hysterectomy for endometrial cancer: a multi-institutional survey in Kinki District, Japan)

    Tanaka Tomohito, Yamashita Suguru, Kuroboshi Haruo, Kamibayashi Junya, Sugiura Atsushi, Yoriki Kaori, Mori Taisuke, Tanaka Kazuharu, Nagashima Aiko, Maeda Michihide, Kamiura Shoji, Mizuno Yukako, Ohtake Noriko, Ichimura Tomoyuki, Kikuchi Taiki, Nobuta Yuri, Amano Tsukuru, Matsumura Noriomi, Nakai Hidekatsu, Kobayashi Eiji, Kamei Yuji, Ukita Masayo, Hamanishi Junzo, Hirayama Junya, Mabuchi Yasushi, Kato Seiko, Fujita Hiroyuki, Kiyota Atsuko, Koyama Shinsuke, Fukui Yosuke, Kimura Mai, Takahashi Ryosuke, Terai Yoshito, Suruga Madoka, Kawanishi Masaru, Nishioka Kazuhiro, Ohmichi Masahide

    International Journal of Clinical Oncology   27 ( 6 )   1084 - 1092   2022.06( ISSN:1341-9625

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    2005〜2020年までの期間内に、近畿地区内医療施設19施設で、子宮内膜癌に対し子宮摘出術が施行された70歳以上の高齢患者1246例(平均年齢75.7±4.9歳)を調査対象とした。対象患者を低リスク群、中等度リスク群、高リスク群に分類し、子宮摘出の術式、リンパ節郭清およびアジュバント療法の有無により、無病生存率と全生存率をKaplan-Meier法で比較し、Cox回帰分析で死亡の相対リスク(RR)を推定した。その結果、死亡の補正RRは、低リスク群の最小侵襲手術(MIS)と開腹術では0.64、リンパ節郭清施行とリンパ節郭清未施行では0.52であった。また、中等度リスク群のMISと開腹術では0.80、リンパ節郭清施行と未施行では0.60で、アジュバント療法施行と未施行では0.89であった。一方、高リスク群のリンパ節郭清施行と未施行では0.56、アジュバント療法施行と未施行では0.60であった。これらの結果から、子宮内膜癌の高齢患者に対しては、子宮に限定したMISの治療転帰は開腹術に劣らないと判断された。

  • A difficult to diagnose case of low-grade endometrial stromal sarcoma with smooth muscle differentiation treated with laparoscopic surgery: A case report.

    Ichimura T, Kasai M, Imai K, Yamauchi M, Fukuda T, Yasui T, Sumi T

    Molecular and clinical oncology   16 ( 4 )   92   2022.04( ISSN:2049-9450

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  • Characteristic of Uterine Rhabdomyosarcoma by Algorithm of Potential Biomarkers for Uterine Mesenchymal Tumor.

    Tamura S, Hayashi T, Ichimura T, Yaegashi N, Abiko K, Konishi I

    Current oncology (Toronto, Ont.)   29 ( 4 )   2350 - 2363   2022.03( ISSN:1198-0052

  • Safety and tolerability of andecaliximab as monotherapy and in combination with an anti-PD-1 antibody in Japanese patients with gastric or gastroesophageal junction adenocarcinoma: a phase 1b study.

    Yoshikawa AK, Yamaguchi K, Muro K, Takashima A, Ichimura T, Sakai D, Kadowaki S, Chin K, Kudo T, Mitani S, Kitano S, Thai D, Zavodovskaya M, Liu J, Boku N, Satoh T

    Journal for immunotherapy of cancer   10 ( 1 )   2022.01

  • Efficacy and safety of maintenance therapy using bevacizumab for advanced ovarian cancer

    NAKAJIMA Asami, FUKUDA Takeshi, SHIBATA Satoshi, AWAZU Yuichiro, NANNO Shigenori, SUEKANE Tomoki, IMAI Kenji, YAMAUCHI Makoto, KASAI Mari, ICHIMURA Tomoyuki, YASUI Tomoyo, SUMI Toshiyuki

    ADVANCES IN OBSTETRICS AND GYNECOLOGY   74 ( 4 )   509 - 514   2022( ISSN:03708446

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  • Uterine metastasis of lobular breast carcinoma under tamoxifen therapy: A case report.

    Awazu Y, Fukuda T, Imai K, Yamauchi M, Kasai M, Ichimura T, Yasui T, Sumi T

    Molecular and clinical oncology   15 ( 6 )   266   2021.12( ISSN:2049-9450

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  • Massive ovarian edema with paraovarian cyst torsion treated with laparoscopic surgery: A case report.

    Fukuda T, Imai K, Yamauchi M, Kasai M, Ichimura T, Yasui T, Sumi T

    Medicine international   1 ( 5 )   17   2021.11( ISSN:2754-3242

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  • Neutrophil-to-lymphocyte ratio is associated with sensitivity to platinum-based chemotherapy and prognosis in patients with advanced serous ovarian carcinoma.

    Fukuda T, Kawanishi M, Awazu Y, Nanno S, Shimomura M, Inoue Y, Matsubara H, Yamauchi M, Kasai M, Hashiguchi Y, Ichimura T, Yasui T, Sumi T

    Molecular and clinical oncology   15 ( 4 )   217   2021.10( ISSN:2049-9450

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  • 当院における75歳以上の高齢子宮体がん患者に対する治療

    菊池 太貴, 橋口 裕紀, 山内 真, 笠井 真理, 福田 武史, 市村 友季, 安井 智代, 角 俊幸

    産婦人科の進歩   73 ( 4 )   382 - 383   2021.10( ISSN:0370-8446

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    当院における75歳以上の高齢子宮体癌患者に対する治療について、2015年1月〜2019年12月に当院で入院加療を行った当該患者44例(75歳〜92歳)を対象に検討した。その結果、44例中40例に手術を施行し、全例に単純子宮全摘出術、両側付属器摘出術を行い、再発中リスク群16例のうち9例では術後化学療法を施行しなかった。術後化学療法を施行しなかった9例中再発例は2例(22%)で、75歳未満の中リスク群で術後化学療法をしなかった5例における再発率(20%)と大差なく、75歳以上の子宮体癌中リスク群においても、術後化学療法を施行しない選択肢も考慮してよいと考えられた。

  • 症例 二次性に卵巣広汎性浮腫を呈した胃癌卵巣転移の1例 Reviewed

    竹内 均, 森本 真美, 田中 里可子, 植木 愛, 市村 友季, 三木 幸雄

    臨床放射線   66 ( 7 )   725 - 728   2021.07( ISSN:00099252

  • 二次性に卵巣広汎性浮腫を呈した胃癌卵巣転移の1例

    竹内 均, 森本 真美, 田中 里可子, 植木 愛, 市村 友季, 三木 幸雄

    臨床放射線   66 ( 7 )   725 - 728   2021.07( ISSN:0009-9252

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    30歳代女性。右内頸静脈血栓で当院循環器内科を紹介受診し、深部静脈血栓の検索目的に施行された腹部造影CTで骨盤内腫瘤を指摘され、婦人科に紹介となった。骨盤部MRIで右卵巣に5×3cmの腫大を認め、内部はT2強調像で全体的に高信号を示し、被膜下に多数の小嚢胞を認めた。捻転を疑わせる卵管の形態変化や卵巣内の出血成分は認めなかった。これらの所見から卵巣広汎性浮腫(MOE)が疑われ、経過観察となった。初回MRIから52日後と104日後のMRIで右卵巣の経時的な増大を認め、左卵巣も軽度増大傾向であった。初回MRIから76日後より両側胸水の増加を認め、106日後に胸水穿刺を行い、腺癌が検出された。卵巣腫瘤との関連が疑われたため試験開腹の方針となり、両側付属器切除術を施行され、病理組織所見から腺癌の両側卵巣転移と診断された。初回MRIから112日後に原発巣の検索目的で上部消化管内視鏡検査を行ったところ胃体下部大彎に陥凹性病変を認めたため生検を施行し、胃癌の卵巣転移による二次性MOEの診断に至った。

  • A survey of 20-year-old Japanese women: how is their intention to undergo cervical cancer screening associated with their childhood HPV vaccination status? Reviewed

    Kakubari R, Egawa-Takata T, Ueda Y, Tanaka Y, Yagi A, Morimoto A, Terai Y, Ohmichi M, Ichimura T, Sumi T, Murata H, Okada H, Nakai H, Matsumura N, Yoshino K, Kimura T, Saito J, Kudo R, Sekine M, Enomoto T, Horikoshi Y, Takagi T, Shimura K

    Hum Vaccin Immunother   17 ( 2 )   434 - 442   2021.02( ISSN:2164-5515

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    Publishing type:Research paper (scientific journal)  

    © 2020 Taylor & Francis Group, LLC. Introduction: In Japan, two groups of women, HPV vaccinated and unvaccinated, are approaching age 20, when they should begin cervical cancer screening. To improve Japan’s current poor cervical cancer screening rate, we need to know how these women are thinking about screening. Methods: We conducted an internet survey of 20-y-old women, exploring their understanding of HPV and cervical cancer screening. We then gave them leaflets with basic information about HPV and cervical cancer, stressing the importance of early detection by screening. We analyzed the leaflet’s effects on their attitudes based on their vaccination status. Results: Our study of 618 women found a significantly higher intention for engagement for cervical cancer screening in women HPV-vaccinated as teenagers (29% versus 17%). They were also more aware that: (1) HPV is transmitted by sexual intercourse (49.1% versus 39.2%); (2) the HPV vaccine prevents cervical cancer (49.0% to 34.0%); and (3) the appropriate cervical cancer screening interval is every 2 y (63.3% versus 56.2%). Women in both groups responded well to the leaflet, with significant improvements in intention to receive screening. However, 65%-67% were not swayed. Discussion: HPV-vaccinated women were more knowledgeable about cervical cancer and had a greater intention to receive screening. Our educational leaflet was moderately effective in both groups for increasing intentions to screen, but the majority in both groups were still resistant to screening. Conclusion: Japan needs to develop more effective educational programs and tools to vigorously impart the importance of cervical cancer screening.

    DOI: 10.1080/21645515.2020.1788326

    PubMed

  • 特集 これでわかる 婦人科稀少腫瘍 外陰腫瘍 悪性黒色腫

    市村 友季, 角 俊幸

    産科と婦人科   88 ( 2 )   223 - 229   2021.02( ISSN:03869792

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  • A survey of 20-year-old Japanese women: how is their intention to undergo cervical cancer screening associated with their childhood HPV vaccination status? Reviewed International coauthorship

    Kakubari R, Egawa-Takata T, Ueda Y, Tanaka Y, Yagi A, Morimoto A, Terai Y, Ohmichi M, Ichimura T, Sumi T, Murata H, Okada H, Nakai H, Matsumura N, Yoshino K, Kimura T, Saito J, Kudo R, Sekine M, Enomoto T, Horikoshi Y, Takagi T, Shimura K

    Hum Vaccin Immunother   17 ( 2 )   434 - 442   2021.02

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    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

  • A case of anti-NMDA receptor encephalitis associated with immature teratoma of the ovary who underwent laparoscopic surgery with suspected microteratoma from imaging examination Reviewed

    Yamauchi M, Nanno S, Shimomura M, Imai K, Fukuda T, Ichimura T, Yasui T, Sumi T

    Advances in obstetrics and gynecology   73 ( 1 )   68 - 72   2021.02

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    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

  • [Rare gynecological tumors understood by this text] Vulvar tumors Malignant melanoma Invited

    Ichimura T, Sumi T

    Obstetrics and gynecology   88 ( 2 )   223 - 229   2021.02

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    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

  • [Rare gynecological tumors understood by this text] Vulvar tumors Malignant melanoma Invited

    Ichimura T, Sumi T

    Obstetrics and gynecology   88 ( 2 )   223 - 229   2021.02

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  • 画像検査から微小な奇形腫を疑い腹腔鏡下手術を行った卵巣未熟奇形腫に伴う抗NMDA受容体脳炎の1例

    山内 真, 南野 成則, 下村 将央, 今井 健至, 福田 武史, 市村 友季, 安井 智代, 角 俊幸

    産婦人科の進歩   73 ( 1 )   68 - 72   2021.02( ISSN:0370-8446

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    抗NMDA受容体脳炎は2007年にDalmauによって提唱された若年女性に好発する自己免疫性辺縁系脳炎であり、腫瘍、とくに卵巣奇形腫に随伴することが多い。今回、明らかな卵巣腫大は認めなかったが、抗NMDA受容体抗体が陽性であり、画像検査にて右卵巣にわずかに脂肪成分を疑う部位を認めたため腹腔鏡手術を施行し、卵巣奇形腫の診断に至った症例を経験したので報告する。19歳1妊未産の女性。当院に入院する11日前から感冒症状が出現。入院4日前の夕に異常行動と全身痙攣を認め前医救急搬送となった。頭部MRIに異常所見は認められなかったが、意識障害の進行と不随意運動を認め脳炎が疑われたため当院神経内科へ紹介となった。その後、ICUへ入室し人工呼吸器管理となった。頭部造影MRIで大脳辺縁系にT2WI高信号域を認め、辺縁系脳炎と考えられた。入院後7日目に抗NMDA受容体抗体が検出され、骨盤部MRIとCTを撮像も明らかな卵巣の腫大は認めなかったが、微小な奇形腫の可能性も考慮し当科紹介となった。当科にて再度MRIと造影CTを撮影したところ、右卵巣に明確ではないがごくわずかに脂肪成分を疑う部位を偶発的に認めたため、腹腔鏡下右付属器摘出術を施行し右卵巣内に割を入れたところ、ごくわずかな脂肪組織を含む腫瘍(大きさ3mm)を認め、摘出標本の病理検査結果は未熟奇形腫grade 1であった。その後、人工呼吸器を離脱し徐々に意識状態は改善した。今回われわれは、微小な卵巣未熟奇形腫に伴う抗NMDA受容体脳炎に対して画像検査を重ねることで微小な病変を疑い、腹腔鏡手術に踏み切り診断と回復に至った1例を経験した。抗NMDA受容体脳炎は意識障害や呼吸障害など重篤な臨床経過をたどることが多く、画像上検出が困難な微小な腫瘍でも本疾患を発症する可能性があることを念頭において、複数回の画像検査実施あるいは撮影条件を変更して画像検査を再検討する必要があると考えられた。(著者抄録)

  • A case of anti-NMDA receptor encephalitis associated with immature teratoma of the ovary who underwent laparoscopic surgery with suspected microteratoma from imaging examination Reviewed

    Yamauchi M, Nanno S, Shimomura M, Imai K, Fukuda T, Ichimura T, Yasui T, Sumi T

    Advances in obstetrics and gynecology   73 ( 1 )   68 - 72   2021.02

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    Publishing type:Research paper (scientific journal)  

  • Atypical endometrial hyperplasia in endometrial polyp diagnosed with resectoscope: A case report

    Nakajima Asami, Ichimura Tomoyuki, Kasai Mari, Yamauchi Makoto, Hashiguchi Yasunori, Yasui Tomoyo, Tamura Kazutomi, Sumi Toshiyuki

    JAPANESE JOURNAL OF GYNECOLOGIC AND OBSTETRIC ENDOSCOPY   37 ( 1 )   149 - 153   2021( ISSN:18849938

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    <p>  Preoperative diagnosis of small uterine endometrial lesions by endometrial curettage biopsy can be difficult because tissue from localized lesions may not be obtained by this procedure. We here report a case of atypical endometrial hyperplasia in an endometrial polyp that was not diagnosed by several endometrial curettage biopsies but was finally diagnosed by resectoscopic partial resection. A 54-year-old woman, gravida 2, para 2 was referred to our hospital because cervical cytology had shown atypical glandular cells-favoring neoplasia. Cervical and endometrial biopsies obtained in our hospital yielded only normal tissue and MRI examination showed no obvious abnormalities. Hysteroscopy revealed a polypoid lesion near the ostium of the left fallopian tube, prompting repeat endometrial curettage biopsy. However, it proved difficult to collect a sample from that polypoid lesion, which was therefore removed via a resectoscope. Histological examination of the specimen thus obtained resulted in a diagnosis of atypical endometrial hyperplasia in an endometrial polyp. Abdominal simple total hysterectomy and bilateral salpingo-oophorectomy was therefore performed. The final pathological diagnosis was also atypical endometrial hyperplasia. We therefore suggest that removal of specimens via a resectoscope may be a useful means of diagnosing endometrial lesions from which it is difficult to collect tissue by endometrial curettage.</p>

    DOI: 10.5180/jsgoe.37.1_149

    CiNii Article

  • レゼクトスコープを用いて診断したatypical endometrial hyperplasia in endometrial polypの1例

    中島 安紗海, 市村 友季, 笠井 真理, 山内 真, 橋口 裕紀, 安井 智代, 田村 一富, 角 俊幸

    日本産科婦人科内視鏡学会雑誌   37 ( 1 )   149 - 153   2021( ISSN:1884-9938

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    症例は2妊2産の54歳女性で、健診の子宮頸部診異常を主訴とした。コルポスコピー観察下の子宮頸管内膜生検、子宮体部内膜生検で診断に至らず、子宮鏡検査で左卵管口付近に10mm大のポリープを認めた。子宮頸管内膜生検を行ったが、判定不可であった。頸部細胞診異常の原因は左卵管口のポリープであるが、10mmとサイズが小さく、掻爬生検では採取されないため、レゼクトスコープを用いてポリープを切除した。術中、子宮穿孔や術後の感染症などの合併症は発生しなかった。摘出したポリープの病理診断はatypical endometrial hyperplasia in endometrial polypであった。腹式単純子宮全摘術と両側付属器摘出術を追加し、病理検査で左卵管口付近の切り出し検体から軽度核異型を伴う腺管を僅かに認めた。それ以外の部位に腫瘍性病変はみられなかった。最終的に子宮体部のatypical endometrial hyperplasia in endometrial polypと診断した。

  • Clinical treatment of 75 years and over patients with endometrial cancer

    KIKUCHI Taiki, HASHIGUCHI Yasunori, YAMAUCHI Makoto, KASAI Mari, FUKUDA Takeshi, ICHIMURA Tomoyuki, YASUI Tomoyo, SUMI Toshiyuki

    ADVANCES IN OBSTETRICS AND GYNECOLOGY   73 ( 4 )   382 - 383   2021( ISSN:03708446

  • A case of lipoleiomyoma performed total laparoscopic hysterectomy that was preoperatively diagnosed as ovarian mature teratoma Reviewed

    Ichimura T, Kasai M, Shimomura M, Yamauchi M, Fukuda T, Hashiguchi Y, Yasui T, Sumi T

    Japanese journal of gynecologic and obstetric endoscopy   36 ( 2 )   198 - 203   2020.12

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    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

  • A case of lipoleiomyoma performed total laparoscopic hysterectomy that was preoperatively diagnosed as ovarian mature teratoma Reviewed

    Ichimura T, Kasai M, Shimomura M, Yamauchi M, Fukuda T, Hashiguchi Y, Yasui T, Sumi T

    Japanese journal of gynecologic and obstetric endoscopy   36 ( 2 )   198 - 203   2020.12

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  • 卵巣成熟奇形腫の術前診断で手術を行うも子宮腫瘍と判明し腹腔鏡下子宮全摘出術を行った脂肪平滑筋腫の1例

    市村 友季, 笠井 真理, 下村 将央, 山内 真, 福田 武史, 橋口 裕紀, 安井 智代, 角 俊幸

    日本産科婦人科内視鏡学会雑誌   36 ( 2 )   198 - 203   2020.12( ISSN:1884-9938

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    症例は71歳3妊3産で、画像所見より左卵巣成熟奇形腫を疑って腹腔鏡下両側付属器摘出術を開始したところ、漿膜下に子宮腫瘍および腹膜に癒着した左卵巣を認めた。術中所見およびMRI所見より子宮脂肪平滑筋腫と判断し、腹腔鏡下単純子宮全摘術および両側付属器摘出術を行った。

  • Tuberculous peritonitis with elevated serum CA125 levels mimicking peritoneal cancer

    Taniwaki A.

    Clinical and Experimental Obstetrics and Gynecology   47 ( 6 )   994 - 996   2020.12( ISSN:03906663

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  • Digenic mutations in ALDH2 and ADH5 impair formaldehyde clearance and cause a multisystem disorder, AMeD syndrome

    Oka Y.

    Science Advances   6 ( 51 )   2020.12

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  • Corona and non-disease New coronavirus infection that spreads Why bats infect humans with the virus Invited

    Pre-illness and anti-aging   29   56 - 61   2020.11

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    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

  • Corona and non-disease New coronavirus infection that spreads Why bats infect humans with the virus Invited

    Pre-illness and anti-aging   29   56 - 61   2020.11( ISSN:1347-667X

  • Secondary small cell vaginal cancer after operative therapy for endometrial cancer

    Shimazaki I.

    European Journal of Gynaecological Oncology   41 ( 5 )   821 - 823   2020.10( ISSN:03922936

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  • A survey of Japanese mothers on the effectiveness of the Ministry of Health, Labor and Welfare's revised HPV vaccine leaflet Reviewed International coauthorship

    Shiomi M, Ueda Y, Abe H, Yagi A, Sakiyama K, Kimura T, Tanaka Y, Ohmichi M, Ichimura T, Sumi T, Murata H, Okada H, Nakai H, Matsumura N, Saito J, Takagi T, Horikoshi Y, Shimura K

    Hum Vaccin Immunother   16 ( 10 )   2555 - 2558   2020.10( ISSN:2164-5515

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    Publishing type:Research paper (scientific journal)   International / domestic magazine:International journal  

    Introduction: In June of 2013, Japan's Ministry of Health, Labor and Welfare (MHLW) suspended its position of strong recommendation for the routine immunization of young girls against the Human Papilloma Virus (HPV) because of reports of adverse reactions after the vaccination. For the next four years, the MHLW's website warned about the significance of these adverse events. In January of 2018, MHLW's website was modified to reflect a less negative stance. We have studied public awareness of MHLW's revised leaflet in Japanese women whose daughters were of the targeted age for receiving the HPV vaccine and how this awareness influenced their intentions to get their daughters vaccinated. Materials and Methods: From June to December of 2018, a survey was conducted through the Departments of Obstetrics and Gynecology at 14 different medical facilities. The questionnaire was distributed to women whose daughters were of the HPV-vaccine-targeted age. The survey measured their responses before and after being presented with the 2018-revised MHLW leaflet. Responses from 384 mothers were analyzed. Results: Before being presented with the leaflet, the survey found that the percentage of responder's daughters already vaccinated was 6.5% (24/372). After reading the MHLW leaflet, an additional 6.9% (24/346) responded "I want to get my daughter vaccinated immediately", and 37.6% (130/346) responded "I have positive feelings about HPV vaccination". Discussion: By presenting the new MHLW leaflet at obstetrics and gynecology facilities, we expect to be able to effectively increase the HPV vaccination rate in Japan.

    DOI: 10.1080/21645515.2020.1723362

    PubMed

  • A survey of Japanese mothers on the effectiveness of the Ministry of Health, Labor and Welfare's revised HPV vaccine leaflet Reviewed International coauthorship

    Shiomi M, Ueda Y, Abe H, Yagi A, Sakiyama K, Kimura T, Tanaka Y, Ohmichi M, Ichimura T, Sumi T, Murata H, Okada H, Nakai H, Matsumura N, Saito J, Takagi T, Horikoshi Y, Shimura K

    Hum Vaccin Immunother   16 ( 10 )   2555 - 2558   2020.10

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  • Characteristics of Leiomyosarcoma: Induction of Hematogenous Metastasis by Isolated Uterine Mesenchymal Tumor Stem-like Cells. Reviewed

    Hayashi T, Sano K, Ichimura T, Kanai Y, Zharhary D, Aburatani H, Yaegashi N, Konishi I

    Anticancer research   40 ( 3 )   1255 - 1265   2020.03( ISSN:0250-7005

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.21873/anticanres.14067

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  • Transcervical needle biopsy: Diagnosis of lesions occurring in the non-epithelial region of the uterus with biopsied specimens Invited

    Tomoyuki Ichimura

    48 ( 3 )   301 - 308   2020.03

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  • Characteristics of Leiomyosarcoma: Induction of Hematogenous Metastasis by Isolated Uterine Mesenchymal Tumor Stem-like Cells. Reviewed

    Hayashi T, Sano K, Ichimura T, Kanai Y, Zharhary D, Aburatani H, Yaegashi N, Konishi I

    Anticancer research   40 ( 3 )   1255 - 1265   2020.03( ISSN:0250-7005

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    Publishing type:Research paper (scientific journal)   International / domestic magazine:International journal  

    BACKGROUND/AIM: Uterine leiomyosarcoma (Ut-LMS) is a refractory tumor that repeatedly recurs with hematogenous metastasis, which may be due to the presence of drug-resistant tumor stem cells. Its treatment is limited to surgical procedures. We previously reported that Ut-LMS spontaneously developed in mice deficient in the proteasome component low-molecular mass polypeptide 2 (LMP2). We showed that LMP2 expression was significantly attenuated specifically in human Ut-LMS. The aim of this study was to investigate the role of LMP2 in hematogenous metastasis using xenograft models with tumor stem-like cells. MATERIALS AND METHODS: We isolated tumor stem-like cells from LMP2-negative primary human Ut-LMS cells established from a human Ut-LMS tissue using the side population (SP) procedure. These cells were used to develop xenograft models with tumor stem-like cells. RESULTS: Human Ut-LMS stem-like cells showed stronger hematogenous metastatic potential than normal Ut-LMS cells. Tumor stem-like cells also had the potential to differentiate into vascular endothelial cells through VEGF-A signaling. CONCLUSION: These results reflect frequent hematogenous metastasis by human Ut-LMS in clinical settings, and may lead to the development of treatments that inhibit hematogenous metastasis in Ut-LMS.

    DOI: 10.21873/anticanres.14067

    PubMed

  • Transcervical needle biopsy: Diagnosis of lesions occurring in the non-epithelial region of the uterus with biopsied specimens Invited

    Tomoyuki Ichimura

    48 ( 3 )   301 - 308   2020.03

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  • HMGCR antibody-associated myopathy in patient with endometrial cancer: A rare case

    Wada T.

    European Journal of Gynaecological Oncology   41 ( 1 )   148 - 150   2020.02( ISSN:03922936

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  • Secondary small cell carcinoma of the endometrium after concurrent chemoradiotherapy for cervical cancer: A rare case

    Tasaka R.

    European Journal of Gynaecological Oncology   41 ( 1 )   142 - 144   2020.02( ISSN:03922936

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  • A case of lipoleiomyoma, preoperatively diagnosed as ovarian mature teratoma, treated with total laparoscopic hysterectomy

    Ichimura Tomoyuki, Kasai Mari, Shimomura Masahiro, Yamauchi Makoto, Fukuda Takeshi, Hashiguchi Yasunori, Yasui Tomoyo, Sumi Toshiyuki

    JAPANESE JOURNAL OF GYNECOLOGIC AND OBSTETRIC ENDOSCOPY   36 ( 2 )   198 - 203   2020( ISSN:18849938

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    <p>  Ovarian mature teratomas present various risks, such as acute abdomen, and hence surgery is the usual protocol. On the other hand, uterine lipoleiomyoma is a variant of uterine leiomyoma, and surgery is not always performed in postmenopausal cases. We report a case of postmenopausal uterine lipoleiomyoma, preoperatively diagnosed as ovarian mature teratoma, and treated surgically. A 71-year-old woman presented a 5.5-cm mass on the left dorsal side of the uterus that was fat suppressed on magnetic resonance imaging. The preoperative diagnosis was mature teratoma of the left ovary.</p><p>  Laparoscopic bilateral salpingo-oophorectomy was planned, but we changed the operative procedure to laparoscopic hysterectomy and bilateral salpingo-oophorectomy. This was because the mass was identified as a uterine mass as no swelling was observed in either ovary during surgery. Pathological examination of the excised specimen revealed lipoleiomyoma. It may be difficult to distinguish uterine lipoleiomyomas from ovarian mature teratomas when the lipoleiomyomas are subserosal. In this case, the tumor was presumed to have originated from the uterus based on the findings of the pelvic examination, and we were able to discuss the operative procedure options in advance. One of the merits of laparoscopic surgery in this case was that the burden of changing the surgical procedure was less than that with laparotomy; however, at the same time, preoperative exclusion of malignant disease was considered important. In the diagnosis of tumors containing fat, the differential diagnosis of lipoleiomyoma should be considered.</p><p></p>

    DOI: 10.5180/jsgoe.36.2_198

    CiNii Article

  • Anti-NMDAreceptorencephalitiswithamicro,undetectableovarianimmature teratoma that led to a definitive diagnosis by laparoscopic surgery

    YAMAUCHI Makoto, NANNO Shigenori, SHIMOMURA Masahiro, IMAI Kenji, FUKUDA Takeshi, ICHIMURA Tomoyuki, YASUI Tomoyo, SUMI Toshiyuki

    ADVANCES IN OBSTETRICS AND GYNECOLOGY   73 ( 1 )   68 - 72   2020( ISSN:03708446

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    <p>Anti-N-methyl-D-aspartate (NMDA) receptor encephalitis is an autoimmune limbic encephalitis that is prevalent in young women with ovarian teratoma. In the present study, we report a case of symptomatic improvement after laparoscopic right salpingo-oophorectomy for anti-NMDA receptor antibody encephalitis associated with a micro ovarian immature teratoma without obvious ovarian enlargement on imaging. A 19-year-old woman was admitted due to seizures to our hospital. She was transferred to our neurology department due to the progression of disorientation and involuntary movements, and encephalitis was suspected. Seventh day of hospitalization, anti-NMDA receptor antibodies were found to be positive. MRI and CT showed an area in the right ovary that was undefined but very faintly suspicious of fatty components, suggesting the presence of a micro ovarian teratoma. The patient underwent a laparoscopic right salpingo-oophorectomy. Pathological examination was immature teratoma, Grade1. Macroscopically, a right ovarian tumor (three mm in size) containing a small amount of fatty tissue was observed. The patient was weaned off the respirator on the fourth postoperative day. Her conscious level gradually improved and she was able to communicate. Careful scrutiny is necessary, bearing in mind that even microscopic teratomas that are difficult to detect on imaging can cause the disease. [Adv Obstet Gynecol, 73 (1) : 68-72, 2021 (R3.2)]</p>

    DOI: 10.11437/sanpunosinpo.73.68

    CiNii Article

  • Comparison of MR imaging features of uterine neuroendocrine carcinoma and uterine malignant lymphoma Reviewed

    Sugimoto Michiko, Koyama Koichi, Ichimura Tomoyuki, Shimono Taro, Hashiguchi Yasunori, Miki Yukio

    ABDOMINAL RADIOLOGY   44 ( 10 )   3377 - 3387   2019.10( ISSN:2366-004X

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00261-019-02201-1

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  • Comparison of MR imaging features of uterine neuroendocrine carcinoma and uterine malignant lymphoma Reviewed

    Sugimoto Michiko, Koyama Koichi, Ichimura Tomoyuki, Shimono Taro, Hashiguchi Yasunori, Miki Yukio

    ABDOMINAL RADIOLOGY   44 ( 10 )   3377 - 3387   2019.10( ISSN:2366-004X

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00261-019-02201-1

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  • SERUM CA125 IN PATIENTS WITH ENDOMETRIAL CANCER Reviewed

    Hashiguchi Y., Yamauchi M., Kasai M., Fukuda T., Ichimura T., Yasui T., Sumi T.

    INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER   29   A170 - A170   2019.09( ISSN:1048-891X

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1136/ijgc-2019-IGCS.409

  • SERUM CA125 IN PATIENTS WITH ENDOMETRIAL CANCER Reviewed

    Hashiguchi Y, Yamauchi M, Kasai M, Fukuda T, Ichimura T, Yasui T, Sumi T

    INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER   29   A170 - A170   2019.09( ISSN:1048-891X

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1136/ijgc-2019-IGCS.409

  • Profiling of Target Molecules for Immunotherapy in Mesenchymal Tumors. Reviewed

    Hayashi T, Ichimura T, Sano K, Tonegawa S, Kanai Y, Zharhary D, Aburatani H, Yaegashi N, Konishi I

    Journal of clinical medicine research   11 ( 8 )   609 - 613   2019.08( ISSN:1918-3003

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    DOI: 10.14740/jocmr3886

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  • Profiling of Target Molecules for Immunotherapy in Mesenchymal Tumors. Reviewed

    Hayashi T, Ichimura T, Sano K, Tonegawa S, Kanai Y, Zharhary D, Aburatani H, Yaegashi N, Konishi I

    Journal of clinical medicine research   11 ( 8 )   609 - 613   2019.08( ISSN:1918-3003

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    DOI: 10.14740/jocmr3886

    PubMed

  • Serous endometrial intraepithelial carcinoma diagnosed by hysteroscopic transcervical resection Reviewed

    Matsubara H., Hashiguchi Y., Kasai M., Fukuda T., Ichimura T., Yasui T., Sumi T.

    EUROPEAN JOURNAL OF GYNAECOLOGICAL ONCOLOGY   40 ( 5 )   889 - 891   2019( ISSN:0392-2936

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.12892/ejgo4645.2019

  • Perivascular epithelioid cell tumor of vulva: a rare case Reviewed

    Tasaka R., Hashiguchi Y., Kasai M., Fukuda T., Ichimura T., Yasui T., Sumi T.

    EUROPEAN JOURNAL OF GYNAECOLOGICAL ONCOLOGY   40 ( 1 )   148 - 150   2019( ISSN:0392-2936

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.12892/ejgo4158.2019

  • Ovarian actinomycosis mimicking ovarian malignant tumor with no history of intra-uterine device: a rare case Reviewed

    Oki E., Hashiguchi Y., Yamauchi M., Kasai M., Fukuda T., Ichimura T., Yasui T., Sumi T.

    CLINICAL AND EXPERIMENTAL OBSTETRICS & GYNECOLOGY   46 ( 6 )   1011 - 1013   2019( ISSN:0390-6663

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.12891/ceog4900.2019

  • Cervical cancer metastatic to the upper part of the ureter: a rare case Reviewed

    Kawanishi M., Hashiguchi Y., Kasai M., Fukuda T., Ichimura T., Yasui T., Sumi T.

    EUROPEAN JOURNAL OF GYNAECOLOGICAL ONCOLOGY   40 ( 2 )   345 - 347   2019( ISSN:0392-2936

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.12892/ejgo4549.2019

  • Serous endometrial intraepithelial carcinoma diagnosed by hysteroscopic transcervical resection Reviewed

    Matsubara H, Hashiguchi Y, Kasai M, Fukuda T, Ichimura T, Yasui T, Sumi T

    EUROPEAN JOURNAL OF GYNAECOLOGICAL ONCOLOGY   40 ( 5 )   889 - 891   2019( ISSN:0392-2936

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.12892/ejgo4645.2019

  • Perivascular epithelioid cell tumor of vulva: a rare case Reviewed

    Tasaka R, Hashiguchi Y, Kasai M, Fukuda T, Ichimura T, Yasui T, Sumi T

    EUROPEAN JOURNAL OF GYNAECOLOGICAL ONCOLOGY   40 ( 1 )   148 - 150   2019( ISSN:0392-2936

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.12892/ejgo4158.2019

  • Ovarian actinomycosis mimicking ovarian malignant tumor with no history of intra-uterine device: a rare case Reviewed

    Oki E, Hashiguchi Y, Yamauchi M, Kasai M, Fukuda T, Ichimura T, Yasui T, Sumi T

    CLINICAL AND EXPERIMENTAL OBSTETRICS & GYNECOLOGY   46 ( 6 )   1011 - 1013   2019( ISSN:0390-6663

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.12891/ceog4900.2019

  • Cervical cancer metastatic to the upper part of the ureter: a rare case Reviewed

    Kawanishi M, Hashiguchi Y, Kasai M, Fukuda T, Ichimura T, Yasui T, Sumi T

    EUROPEAN JOURNAL OF GYNAECOLOGICAL ONCOLOGY   40 ( 2 )   345 - 347   2019( ISSN:0392-2936

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.12892/ejgo4549.2019

  • Primary small cell ovarian carcinoma of the pulmonary type Reviewed

    Hashiguchi Yasunori, Yamauchi Makoto, Kasai Mari, Fukuda Takeshi, Ichimura Tomoyuki, Yasui Tomoyo, Sumi Toshiyuki

    INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER   28   48 - 48   2018.10( ISSN:1048-891X

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  • Primary small cell ovarian carcinoma of the pulmonary type Reviewed

    Hashiguchi Yasunori, Yamauchi Makoto, Kasai Mari, Fukuda Takeshi, Ichimura Tomoyuki, Yasui Tomoyo, Sumi Toshiyuki

    INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER   28   48 - 48   2018.10( ISSN:1048-891X

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  • Age-related differences in prognosis and prognostic factors among patients with epithelial ovarian cancer Reviewed

    Yoshikawa Kenji, Fukuda Takeshi, Uemura Ryo, Matsubara Hiroaki, Wada Takuma, Kawanishi Masaru, Tasaka Reiko, Kasai Mari, Hashiguchi Yasunori, Ichimura Tomoyuki, Yasui Tomoyo, Sumi Toshiyuki

    MOLECULAR AND CLINICAL ONCOLOGY   9 ( 3 )   329 - 334   2018.09( ISSN:2049-9450

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.3892/mco.2018.1668

    PubMed

  • 当院におけるAGCの管理 Reviewed

    笠井 真理, 植村 遼, 松原 裕明, 川西 勝, 和田 卓磨, 田坂 玲子, 福田 武史, 市村 友季, 橋口 裕紀, 安井 智代, 角 俊幸

    「産婦人科の進歩」編集室 産婦人科の進歩   70 ( 4 )   349 - 352   2018.09( ISSN:0370-8446

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    ベセスダシステムではAGC(異型腺細胞)の判定は特定の前癌病変を指すのではなく、癌へのリスクの高さを示す診断カテゴリーとされるが、基準が定まらず管理に苦慮することが多い。当院におけるAGCの管理(精査・フォローアップの方針)は、コルポ下生検と頸管内膜生検に加え体部内膜生検も積極的に行い、AGCを反復する症例で生検を複数回行っても診断がつかない場合には診断的円錐切除術を考慮する。今回、当院がベセスダシステムに完全移行した2015年から2017年までにAGCと判定された症例の転帰と臨床的取り扱いについて後方視的に検討した結果、当院のAGC管理は妥当と考えられた。

  • NEUTROPHIL-TO-LYMPHOCYTE RATIO IS ASSOCIATED WITH SENSITIVITY TO PLATINUM-BASED CHEMOTHERAPY AND PROGNOSIS FOR ADVANCED OVARIAN SEROUS CARCINOMA Reviewed

    Shimomura M., Fukuda T., Yamauchi M., Kasai M., Hashiguchi Y., Ichimura T., Yasui T., Sumi T.

    INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER   28   834 - 834   2018.09( ISSN:1048-891X

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  • EVALUATION OF EFFICACY AND SAFETY OF BEVACIZUMAB FOR ADVANCE AND RECURRENT M.LLERIAN CARCINOMA IN OUR INSTITUTION Reviewed

    Matsubara H., Fukuda T., Yamauchi M., Kasai M., Hashiguchi Y., Ichimura T., Yasui T., Sumi T.

    INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER   28   762 - 762   2018.09( ISSN:1048-891X

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  • CERVICAL CLEAR CELL CARCINOMA: REPORT OF A CASE Reviewed

    Yamauchi M., Takeshi F., Kasai M., Hashiguchi Y., Ichimura T., Yasui T., Sumi T.

    INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER   28   579 - 579   2018.09( ISSN:1048-891X

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  • Age-related differences in prognosis and prognostic factors among patients with epithelial ovarian cancer Reviewed

    Yoshikawa Kenji, Fukuda Takeshi, Uemura Ryo, Matsubara Hiroaki, Wada Takuma, Kawanishi Masaru, Tasaka Reiko, Kasai Mari, Hashiguchi Yasunori, Ichimura Tomoyuki, Yasui Tomoyo, Sumi Toshiyuki

    MOLECULAR AND CLINICAL ONCOLOGY   9 ( 3 )   329 - 334   2018.09( ISSN:2049-9450

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.3892/mco.2018.1668

    PubMed

  • NEUTROPHIL-TO-LYMPHOCYTE RATIO IS ASSOCIATED WITH SENSITIVITY TO PLATINUM-BASED CHEMOTHERAPY AND PROGNOSIS FOR ADVANCED OVARIAN SEROUS CARCINOMA Reviewed

    Shimomura M, Fukuda T, Yamauchi M, Kasai M, Hashiguchi Y, Ichimura T, Yasui T, Sumi T

    INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER   28   834 - 834   2018.09( ISSN:1048-891X

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  • EVALUATION OF EFFICACY AND SAFETY OF BEVACIZUMAB FOR ADVANCE AND RECURRENT M.LLERIAN CARCINOMA IN OUR INSTITUTION Reviewed

    Matsubara H, Fukuda T, Yamauchi M, Kasai M, Hashiguchi Y, Ichimura T, Yasui T, Sumi T

    INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER   28   762 - 762   2018.09( ISSN:1048-891X

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  • CERVICAL CLEAR CELL CARCINOMA: REPORT OF A CASE Reviewed

    Yamauchi M, Takeshi F, Kasai M, Hashiguchi Y, Ichimura T, Yasui T, Sumi T

    INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER   28   579 - 579   2018.09( ISSN:1048-891X

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  • 当院におけるAGCの管理

    笠井 真理, 植村 遼, 松原 裕明, 川西 勝, 和田 卓磨, 田坂 玲子, 福田 武史, 市村 友季, 橋口 裕紀, 安井 智代, 角 俊幸

    産婦人科の進歩   70 ( 4 )   349 - 352   2018.09( ISSN:0370-8446

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    ベセスダシステムではAGC(異型腺細胞)の判定は特定の前癌病変を指すのではなく、癌へのリスクの高さを示す診断カテゴリーとされるが、基準が定まらず管理に苦慮することが多い。当院におけるAGCの管理(精査・フォローアップの方針)は、コルポ下生検と頸管内膜生検に加え体部内膜生検も積極的に行い、AGCを反復する症例で生検を複数回行っても診断がつかない場合には診断的円錐切除術を考慮する。今回、当院がベセスダシステムに完全移行した2015年から2017年までにAGCと判定された症例の転帰と臨床的取り扱いについて後方視的に検討した結果、当院のAGC管理は妥当と考えられた。

  • Examination of the use of needle biopsy to perform laparoscopic surgery safely on uterine smooth muscle tumors Reviewed

    Murakami Makoto, Ichimura Tomoyuki, Kasai Mari, Matsuda Makiko, Kawamura Naoki, Fukuda Takeshi, Sumi Toshiyuki

    ONCOLOGY LETTERS   15 ( 6 )   8647 - 8651   2018.06( ISSN:1792-1074

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    DOI: 10.3892/ol.2018.8425

    PubMed

  • Examination of the use of needle biopsy to perform laparoscopic surgery safely on uterine smooth muscle tumors.

    Murakami M, Ichimura T, Kasai M, Matsuda M, Kawamura N, Fukuda T, Sumi T

    Oncology letters   15 ( 6 )   8647 - 8651   2018.06( ISSN:1792-1074

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  • 20歳の娘に子宮頸癌スクリーニングを薦めるための母親への動機づけ ランダム化研究(Motivating Mothers to Recommend Their 20-Year-Old Daughters Receive Cervical Cancer Screening: A Randomized Study) Reviewed

    Egawa-Takata Tomomi, Ueda Yutaka, Morimoto Akiko, Tanaka Yusuke, Yagi Asami, Terai Yoshito, Ohmichi Masahide, Ichimura Tomoyuki, Sumi Toshiyuki, Murata Hiromi, Okada Hidetaka, Nakai Hidekatsu, Mandai Masaki, Matsuzaki Shinya, Kobayashi Eiji, Yoshino Kiyoshi, Kimura Tadashi, Saito Junko, Hori Yumiko, Morii Eiichi, Nakayama Tomio, Asai-Sato Mikiko, Miyagi Etsuko, Sekine Masayuki, Enomoto Takayuki, Horikoshi Yorihiko, Takagi Tetsu, Shimura Kentaro, OCEAN Study Group(Obstetrical Gynecological Society of Osaka)

    日本疫学会 Journal of Epidemiology   28 ( 3-4 )   156 - 160   2018.04( ISSN:0917-5040

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    <Highlight>・日本の子宮頸がん検診受診率は特に20代で低い。・子宮頸がん検診未受診の20歳女性に対して、様々な受診勧奨の方法について効果を検証した。・20歳女性に対する子宮頸がん検診受診勧奨の方法として、母親を介した受診勧奨が効果的であることが明らかとなった。(著者抄録)

  • 20歳の娘に子宮頸癌スクリーニングを薦めるための母親への動機づけ ランダム化研究(Motivating Mothers to Recommend Their 20-Year-Old Daughters Receive Cervical Cancer Screening: A Randomized Study)

    Egawa-Takata Tomomi, Ueda Yutaka, Morimoto Akiko, Tanaka Yusuke, Yagi Asami, Terai Yoshito, Ohmichi Masahide, Ichimura Tomoyuki, Sumi Toshiyuki, Murata Hiromi, Okada Hidetaka, Nakai Hidekatsu, Mandai Masaki, Matsuzaki Shinya, Kobayashi Eiji, Yoshino Kiyoshi, Kimura Tadashi, Saito Junko, Hori Yumiko, Morii Eiichi, Nakayama Tomio, Asai-Sato Mikiko, Miyagi Etsuko, Sekine Masayuki, Enomoto Takayuki, Horikoshi Yorihiko, Takagi Tetsu, Shimura Kentaro, OCEAN Study Group(Obstetrical Gynecological Society of Osaka)

    Journal of Epidemiology   28 ( 3-4 )   156 - 160   2018.04( ISSN:0917-5040

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    <Highlight>・日本の子宮頸がん検診受診率は特に20代で低い。・子宮頸がん検診未受診の20歳女性に対して、様々な受診勧奨の方法について効果を検証した。・20歳女性に対する子宮頸がん検診受診勧奨の方法として、母親を介した受診勧奨が効果的であることが明らかとなった。(著者抄録)

  • 20歳の娘に子宮頸癌スクリーニングを薦めるための母親への動機づけ ランダム化研究(Motivating Mothers to Recommend Their 20-Year-Old Daughters Receive Cervical Cancer Screening: A Randomized Study) Reviewed

    Egawa-Takata Tomomi, Ueda Yutaka, Morimoto Akiko, Tanaka Yusuke, Yagi Asami, Terai Yoshito, Ohmichi Masahide, Ichimura Tomoyuki, Sumi Toshiyuki, Murata Hiromi, Okada Hidetaka, Nakai Hidekatsu, Mandai Masaki, Matsuzaki Shinya, Kobayashi Eiji, Yoshino Kiyoshi, Kimura Tadashi, Saito Junko, Hori Yumiko, Morii Eiichi, Nakayama Tomio, Asai-Sato Mikiko, Miyagi Etsuko, Sekine Masayuki, Enomoto Takayuki, Horikoshi Yorihiko, Takagi Tetsu, Shimura Kentaro, OCEAN Study Group(Obstetrical Gynecological Societ

    日本疫学会 Journal of Epidemiology   28 ( 3-4 )   156 - 160   2018.04( ISSN:0917-5040

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    Publishing type:Research paper (scientific journal)  

    <Highlight>・日本の子宮頸がん検診受診率は特に20代で低い。・子宮頸がん検診未受診の20歳女性に対して、様々な受診勧奨の方法について効果を検証した。・20歳女性に対する子宮頸がん検診受診勧奨の方法として、母親を介した受診勧奨が効果的であることが明らかとなった。(著者抄録)

  • Motivating Mothers to Recommend Their 20-Year-Old Daughters Receive Cervical Cancer Screening: A Randomized Study

    Egawa-Takata Tomomi, Ueda Yutaka, Morimoto Akiko, Tanaka Yusuke, Yagi Asami, Terai Yoshito, Ohmichi Masahide, Ichimura Tomoyuki, Sumi Toshiyuki, Murata Hiromi, Okada Hidetaka, Nakai Hidekatsu, Mandai Masaki, Matsuzaki Shinya, Kobayashi Eiji, Yoshino Kiyoshi, Kimura Tadashi, Saito Junko, Hori Yumiko, Morii Eiichi, Nakayama Tomio, Asai-Sato Mikiko, Miyagi Etsuko, Sekine Masayuki, Enomoto Takayuki, Horikoshi Yorihiko, Takagi Tetsu, Shimura Kentaro

    Journal of Epidemiology   28 ( 3 )   156 - 160   2018.03( ISSN:0917-5040

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    Publishing type:Research paper (scientific journal)   International / domestic magazine:Domestic journal  

    <p><b>Background:</b> In Japan, the rate of cervical cancer screening is remarkably low, especially among women in their twenties and thirties, when cervical cancer is now increasing dramatically. The aim of this study was to test whether a modified government reminder for 20-year-old women to engage in cervical cancer screening, acting through maternal education and by asking for a maternal recommendation to the daughter to receive the screening, could increase their participation rate.</p><p><b>Methods:</b> In two Japanese cities, 20-year-old girls who had not received their first cervical cancer screening before October of fiscal year 2014 were randomized into two study arms. One group of 1,274 received only a personalized daughter-directed reminder leaflet for cervical cancer screening. In the second group of 1,274, the daughters and their mothers received a combination package containing the same reminder leaflet as did the first group, plus an additional informational leaflet for the mother, which requested that the mother recommend that her daughter undergo cervical cancer screening. The subsequent post-reminder screening rates of these two study arms were compared.</p><p><b>Results:</b> The cervical cancer screening rate of 20-year-old women whose mothers received the information leaflet was significantly higher than that for women who received only a leaflet for themselves (11% vs 9%, <i>P</i> = 0.0049).</p><p><b>Conclusions:</b> An intervention with mothers, by sending them a cervical cancer information leaflet with a request that they recommend that their daughter receive cervical cancer screening, significantly improved their daughters’ screening rate.</p>

    DOI: 10.2188/jea.JE20160155

    PubMed

    CiNii Article

  • Possibility of preoperative diagnosis using exosomes for uterine leiomyosarcoma Reviewed

    Hayashi Takuma, Ichimura Tomoyuki, Aburatani Hiroyuki, Tonegawa Susumu, Yaegashi Nobuo, Konishi Ikuo

    CANCER SCIENCE   109   341 - 341   2018.01( ISSN:1349-7006

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  • Possibility of preoperative diagnosis using exosomes for uterine leiomyosarcoma Reviewed

    Hayashi Takuma, Ichimura Tomoyuki, Aburatani Hiroyuki, Tonegawa Susumu, Yaegashi Nobuo, Konishi Ikuo

    CANCER SCIENCE   109   341 - 341   2018.01( ISSN:1349-7006

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  • Management of AGC Reviewed

    KASAI Mari, YASUI Tomoyo, SUMI Toshiyuki, UEMURA Ryo, MATSUBARA Hiroaki, KAWANISHI Masaru, WADA Takuma, TASAKA Reiko, FUKUDA Takeshi, ICHIMURA Tomoyuki, HASHIGUCHI Yasunori

    THE OBSTETRICAL GYNECOLOGICAL SOCIETY OF KINKI DISTRICT JAPAN, ADVANCES IN OBSTETRICS AND GYNECOLOGY   70 ( 4 )   349 - 352   2018( ISSN:0370-8446

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    DOI: 10.11437/sanpunosinpo.70.349

    CiNii Article

  • Time-dependent changes of the intention of mothers in Japan to inoculate their daughters with the HPV vaccine after suspension of governmental recommendation Reviewed

    Yagi Asami, Ueda Yutaka, Tanaka Yusuke, Nakae Ruriko, Kakubari Reisa, Morimoto Akiko, Terai Yoshito, Ohmichi Masahide, Ichimura Tomoyuki, Sumi Toshiyuki, Murata Hiromi, Okada Hidetaka, Nakai Hidekatsu, Matsumura Noriomi, Yoshino Kiyoshi, Kimura Tadashi, Saito Junko, Ikeda Sayaka, Asai-Sato Mikiko, Miyagi Etsuko, Sekine Masayuki, Enomoto Takayuki, Hirai Kei, Horikoshi Yorihiko, Takagi Tetsu, Shimura Kentaro

    HUMAN VACCINES & IMMUNOTHERAPEUTICS   14 ( 10 )   2497 - 2502   2018( ISSN:2164-5515

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1080/21645515.2018.1480240

    PubMed

  • Small cell ovarian carcinoma of the pulmonary type: a rare case Reviewed

    Kawanishi M., Hashiguchi Y., Kasai M., Fukuda T., Ichimura T., Yasui T., Sumi T.

    EUROPEAN JOURNAL OF GYNAECOLOGICAL ONCOLOGY   39 ( 2 )   297 - 299   2018( ISSN:0392-2936

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.12892/ejgo3609.2018

  • Motivating Mothers to Recommend Their 20-Year-Old Daughters Receive Cervical Cancer Screening: A Randomized Study Reviewed

    Egawa-Takata Tomomi, Ueda Yutaka, Morimoto Akiko, Tanaka Yusuke, Yagi Asami, Terai Yoshito, Ohmichi Masahide, Ichimura Tomoyuki, Sumi Toshiyuki, Murata Hiromi, Okada Hidetaka, Nakai Hidekatsu, Mandai Masaki, Matsuzaki Shinya, Kobayashi Eiji, Yoshino Kiyoshi, Kimura Tadashi, Saito Junko, Hori Yumiko, Morii Eiichi, Nakayama Tomio, Asai-Sato Mikiko, Miyagi Etsuko, Sekine Masayuki, Enomoto Takayuki, Horikoshi Yorihiko, Takagi Tetsu, Shimura Kentaro

    日本疫学会 JOURNAL OF EPIDEMIOLOGY   28 ( 3 )   156 - 160   2018( ISSN:0917-5040

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    Publishing type:Research paper (scientific journal)  

    <p><b>Background:</b> In Japan, the rate of cervical cancer screening is remarkably low, especially among women in their twenties and thirties, when cervical cancer is now increasing dramatically. The aim of this study was to test whether a modified government reminder for 20-year-old women to engage in cervical cancer screening, acting through maternal education and by asking for a maternal recommendation to the daughter to receive the screening, could increase their participation rate.</p><p><b>Methods:</b> In two Japanese cities, 20-year-old girls who had not received their first cervical cancer screening before October of fiscal year 2014 were randomized into two study arms. One group of 1,274 received only a personalized daughter-directed reminder leaflet for cervical cancer screening. In the second group of 1,274, the daughters and their mothers received a combination package containing the same reminder leaflet as did the first group, plus an additional informational leaflet for the mother, which requested that the mother recommend that her daughter undergo cervical cancer screening. The subsequent post-reminder screening rates of these two study arms were compared.</p><p><b>Results:</b> The cervical cancer screening rate of 20-year-old women whose mothers received the information leaflet was significantly higher than that for women who received only a leaflet for themselves (11% vs 9%, <i>P</i> = 0.0049).</p><p><b>Conclusions:</b> An intervention with mothers, by sending them a cervical cancer information leaflet with a request that they recommend that their daughter receive cervical cancer screening, significantly improved their daughters' screening rate.</p>

    DOI: 10.2188/jea.JE20160155

    PubMed

    CiNii Article

  • Small cell ovarian carcinoma of the pulmonary type: A rare case Reviewed

    M. Kawanishi, Y. Hashiguchi, M. Kasai, T. Fukuda, T. Ichimura, T. Yasui, T. Sumi

    European Journal of Gynaecological Oncology   39 ( 2 )   297 - 299   2018( ISSN:0392-2936

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    Background: Small cell ovarian carcinoma of the pulmonary type is extremely rare. It is extremely aggressive and progressive, and there are no established treatment guidelines. Case: A 55-year-old woman presented with small cell ovarian carcinoma of the pulmonary type. Postoperatively the patient received chemotherapy combining cisplatin and irinotecan. To date, nine months after operation, the patient is alive with no evidence of recurrence or metastasis. Conclusion: In case of small cell ovarian carcinoma of the pulmonary type, chemotherapy regimen used for small cell lung cancer, such as chemotherapy combining cisplatin and irinotecan, should be considered.

    DOI: 10.12892/ejgo3609.2018

  • Time-dependent changes of the intention of mothers in Japan to inoculate their daughters with the HPV vaccine after suspension of governmental recommendation. Reviewed

    Asami Yagi, Yutaka Ueda, Yusuke Tanaka, Ruriko Nakae, Reisa Kakubari, Akiko Morimoto, Yoshito Terai, Masahide Ohmichi, Tomoyuki Ichimura, Toshiyuki Sumi, Hiromi Murata, Hidetaka Okada, Hidekatsu Nakai, Noriomi Matsumura, Kiyoshi Yoshino, Tadashi Kimura, Junko Saito, Sayaka Ikeda, Mikiko Asai-Sato, Etsuko Miyagi, Masayuki Sekine, Takayuki Enomoto, Kei Hirai, Yorihiko Horikoshi, Tetsu Takagi, Kentaro Shimura

    Human vaccines & immunotherapeutics   14 ( 10 )   2497 - 2502   2018( ISSN:2164-5515

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    Publishing type:Research paper (scientific journal)   International / domestic magazine:International journal  

    In Japan, the trend for cervical cancer at younger ages has been increasing. As a countermeasure, the HPV vaccine was introduced as a routine vaccination in April 2013. However, the Ministry of Health, Labour and Welfare (MHLW) announced a "Suspension of its active inoculation recommendation for HPV vaccine" in June 2013. In 2016, 32 months after that suspension, we conducted survey via Internet and compared the results with our previous ones conducted at 9 and 23 months after suspension (in 2014 and 2015, respectively). We examined the 'time-dependent change' of the 'intention of mothers to inoculate their daughters with the HPV vaccine' in terms of efficacy of external decision-making support. 17.5% of mothers in the first survey replied that they would inoculate their daughters under the current circumstances, 12.1% in the second survey, and 6.7% in the third, showing a consistent decrease in willingness over time (p = 0.03, p < 0.01). If the government recommendation were to be reintroduced, 22.5% of mothers in the first survey replied they would inoculate their daughters, 21.0% in the second survey, which indicated no significant difference (p = 0.65) over the first interval; however, this was significantly decreased to 12.2% in the third survey (p < 0.01). Our study revealed that the intention to inoculate their daughters has been declining among Japanese mothers over time triggered by the suspension.

    DOI: 10.1080/21645515.2018.1480240

    PubMed

  • Management of AGC

    KASAI Mari, UEMURA Ryo, MATSUBARA Hiroaki, KAWANISHI Masaru, WADA Takuma, TASAKA Reiko, FUKUDA Takeshi, ICHIMURA Tomoyuki, HASHIGUCHI Yasunori, YASUI Tomoyo, SUMI Toshiyuki

    ADVANCES IN OBSTETRICS AND GYNECOLOGY   70 ( 4 )   349 - 352   2018( ISSN:03708446

  • Serum CA19-9 in patients with endometrial cancer. Reviewed

    Hashiguchi Y, Kasai M, Fukuda T, Ichimura T, Yasui T, Sumi T

    Annals of oncology : official journal of the European Society for Medical Oncology   28 Suppl 9   ix94   2017.10( ISSN:0923-7534

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    DOI: 10.1093/annonc/mdx697.086

    PubMed

  • Serum CA19-9 in patients with endometrial cancer Reviewed

    Hashiguchi Yasunori, Kasai Mari, Fukuda Takeshi, Ichimura Tomoyuki, Yasui Tomoyo, Sumi Toshiyuki

    ANNALS OF ONCOLOGY   28   2017.10( ISSN:0923-7534

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  • Serum CA19-9 in patients with endometrial cancer. Reviewed

    Hashiguchi Y, Kasai M, Fukuda T, Ichimura T, Yasui T, Sumi T

    Annals of oncology : official journal of the European Society for Medical Oncology   28 Suppl 9   ix94   2017.10( ISSN:0923-7534

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/annonc/mdx697.086

  • Serum CA19-9 in patients with endometrial cancer Reviewed

    Hashiguchi Yasunori, Kasai Mari, Fukuda Takeshi, Ichimura Tomoyuki, Yasui Tomoyo, Sumi Toshiyuki

    ANNALS OF ONCOLOGY   28   2017.10( ISSN:0923-7534

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  • 当院におけるリンパ嚢胞の発生因子についての検討 Reviewed

    笠井 真理, 和田 卓磨, 川西 勝, 田坂 玲子, 今井 健至, 福田 武史, 橋口 裕紀, 市村 友季, 安井 智代, 角 俊幸

    「産婦人科の進歩」編集室 産婦人科の進歩   69 ( 3 )   318 - 320   2017.08( ISSN:0370-8446

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    当院で後腹膜リンパ節生検または郭清を含む婦人科悪性腫瘍手術を施行した95例(年齢中央値55歳)を対象に、リンパ嚢胞発生のリスクファクターについて検討した。その結果、リンパ嚢胞発生率は35%、症候性リンパ嚢胞の発生率は4%であった。リンパ嚢胞発生のリスクファクターとしては年齢、BMI、摘出リンパ節数、鼠径上リンパ節摘出の有無、傍大動脈リンパ節摘出の有無、リンパ節転移の有無が明らかになった。リンパ浮腫のリスク因子はリンパ嚢胞のリスク因子と重複しており、リンパ浮腫を管理すると同時にリンパ嚢胞の有無を確認し、症候性リンパ嚢胞に対しては速やかに適切に対応することで、QOLを損ねず、がん治療がスムーズに継続できると考えられた。

  • 当院におけるリンパ嚢胞の発生因子についての検討

    笠井 真理, 和田 卓磨, 川西 勝, 田坂 玲子, 今井 健至, 福田 武史, 橋口 裕紀, 市村 友季, 安井 智代, 角 俊幸

    産婦人科の進歩   69 ( 3 )   318 - 320   2017.08( ISSN:0370-8446

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    当院で後腹膜リンパ節生検または郭清を含む婦人科悪性腫瘍手術を施行した95例(年齢中央値55歳)を対象に、リンパ嚢胞発生のリスクファクターについて検討した。その結果、リンパ嚢胞発生率は35%、症候性リンパ嚢胞の発生率は4%であった。リンパ嚢胞発生のリスクファクターとしては年齢、BMI、摘出リンパ節数、鼠径上リンパ節摘出の有無、傍大動脈リンパ節摘出の有無、リンパ節転移の有無が明らかになった。リンパ浮腫のリスク因子はリンパ嚢胞のリスク因子と重複しており、リンパ浮腫を管理すると同時にリンパ嚢胞の有無を確認し、症候性リンパ嚢胞に対しては速やかに適切に対応することで、QOLを損ねず、がん治療がスムーズに継続できると考えられた。

  • Realistic fear of cervical cancer risk in Japan depending on birth year. Reviewed

    Asami Yagi, Yutaka Ueda, Tomomi Egawa-Takata, Yusuke Tanaka, Ruriko Nakae, Akiko Morimoto, Yoshito Terai, Masahide Ohmichi, Tomoyuki Ichimura, Toshiyuki Sumi, Hiromi Murata, Hidetaka Okada, Hidekatsu Nakai, Masaki Mandai, Shinya Matsuzaki, Eiji Kobayashi, Kiyoshi Yoshino, Tadashi Kimura, Junko Saito, Yumiko Hori, Eiichi Morii, Tomio Nakayama, Yukio Suzuki, Yoko Motoki, Akiko Sukegawa, Mikiko Asai-Sato, Etsuko Miyagi, Manako Yamaguchi, Risa Kudo, Sosuke Adachi, Masayuki Sekine, Takayuki Enomoto, Yorihiko Horikoshi, Tetsu Takagi, Kentaro Shimura

    Human vaccines & immunotherapeutics   13 ( 7 )   1700 - 1704   2017.07( ISSN:2164-5515

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    Publishing type:Research paper (scientific journal)   International / domestic magazine:International journal  

    OBJECTIVE: In Japan, the possible adverse events upon HPV vaccination was widely reported in the media. MHLW announced the suspension of aggressively encouraging HPV vaccination in 2013, and inoculation rate has sharply declined. The aim of the present study was estimation of future cervical cancer risk. METHODS: The latest data on vaccination rate at each age in Sakai City were first investigated. The rate of experiencing sexual intercourse at the age of 12, 13, 14, 15, 16, 17 and throughout lifetime is assumed to be 0%, 1%, 2%, 5%, 15%, 25%, and 85% respectively. The cervical cancer risk was regarded to be proportional to the relative risk of HPV infection over the lifetime. The risk in those born in 1993 whom HPV vaccination was not available yet for was defined to be 1.0000. RESULTS: The cumulative vaccination rates were 65.8% in those born in 1994, 72.7% in 1995, 72.8% in 1996, 75.7% in 1997, 75.0% in 1998, 66.8% in 1999, 4.1% in 2000, 1.5% in 2001, 0.1% in 2002, and 0.1% in 2003. The relative cervical cancer risk in those born in 1994-1999 was reduced to 0.56-0.70, however, the rate in those born in 2000-2003 was 0.98-1.0, almost the same risk as before introduction of the vaccine. DISCUSSION: The cumulative initial vaccination rates were different by the year of birth. It is confirmed that the risk of future cervical cancer differs in accordance with the year of birth. For these females, cervical cancer screening should be recommended more strongly.

    DOI: 10.1080/21645515.2017.1292190

    PubMed

  • A novel diagnostic biomarker for human uterine leiomyosarcoma: PSMB9/beta 1i Reviewed

    Hayashi Takuma, Kawano Miki, Sano Kenji, Ichimura Tomoyuki, Gur Gal, Yaish Pnina, Zharhary Dorit, Kanai Yae, Tonegawa Susumu, Shiozawa Tanri, Yaegashi Nobuo, Konishi Ikuo

    CHINESE CLINICAL ONCOLOGY   6 ( 2 )   22   2017.04( ISSN:2304-3865

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    DOI: 10.21037/cco.2017.04.03

    PubMed

  • Characterization of Leiomyomatoid Angiomatous Neuroendocrine Tumour (LANT)-like Tumour in the Myometrium with Histopathological Examination Reviewed

    Hayashi Takuma, Ichimura Tomoyuki, Kasai Mari, Sano Kenji, Zharhary Dorit, Shiozawa Tanri, Yaegashi Nobuo, Konishi Ikuo

    ANTICANCER RESEARCH   37 ( 4 )   1765 - 1772   2017.04( ISSN:0250-7005

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.21873/anticanres.11509

    PubMed

  • Characterization of leiomyomatoid angiomatous neuroendocrine tumour (LANT)-like tumour in the myometrium with histopathological examination Reviewed

    Takuma Hayashi, Tomoyuki Ichimura, Mari Kasai, Kenji Sano, Dorit Zharhary, Tanri Shiozawa, Nobuo Yaegashi, Ikuo Konishi

    Anticancer Research   37 ( 4 )   1765 - 1772   2017.04( ISSN:0250-7005

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    Publishing type:Research paper (scientific journal)  

    Leiomyomatoid angiomatous neuroendocrine tumour (LANT) is possibly a new disease entity that was reported as a dimorphic neurosecretory tumour with a leiomyomatous vascular component
    it was found in the pituitary. We describe uterine LANT-like malignant tumour in a 45-year-old woman with uterine mesenchymal tumour, diagnosed clinically as uterine leiomyoma. She underwent laparoscopic myomectomy. The tumour consisted of hyalinized vasculature, containing factor VIII-positive endothelium and α-smooth muscle actin-positive vascular smooth muscle cells, and stromal cells, expressing neuroadhesion molecules. Both vascular and stromal components diffusely expressed chromogranin A. Histopathological examinations of uterine LANT-like malignant tumour revealed the common characteristic abnormalities of malignant uterine mesenchymal tumours, i.e. leiomyosarcomas. From our research, defective expression of calponin H1 and proteasome ß9 (PSMB9)/ß1i is observed in uterine LANT-like malignant tumour similarly to immunopathological findings of uterine leiomyosarcoma. These findings meet the definition of uterine LANT-like malignant tumour, and the research findings of our clinical case suggest that LANT is a special type of neuroendocrine neoplasm and is not organ specific.

    DOI: 10.21873/anticanres.11509

    PubMed

  • A novel diagnostic biomarker for human uterine leiomyosarcoma: PSMB9/beta 1i Reviewed

    Hayashi Takuma, Kawano Miki, Sano Kenji, Ichimura Tomoyuki, Gur Gal, Yaish Pnina, Zharhary Dorit, Kanai Yae, Tonegawa Susumu, Shiozawa Tanri, Yaegashi Nobuo, Konishi Ikuo

    CHINESE CLINICAL ONCOLOGY   6 ( 2 )   22   2017.04( ISSN:2304-3865

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.21037/cco.2017.04.03

    PubMed

  • A retrospective clinical analysis of 5 cases of vaginal melanoma Reviewed

    Tasaka Reiko, Fukuda Takeshi, Wada Takuma, Kawanishi Masaru, Imai Kenji, Kasai Mari, Hashiguchi Yasunori, Ichimura Tomoyuki, Yasui Tomoyo, Sumi Toshiyuki

    MOLECULAR AND CLINICAL ONCOLOGY   6 ( 3 )   373 - 376   2017.03( ISSN:2049-9450

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.3892/mco.2017.1158

    PubMed

  • A retrospective clinical analysis of 5 cases of vaginal melanoma Reviewed

    Tasaka Reiko, Fukuda Takeshi, Wada Takuma, Kawanishi Masaru, Imai Kenji, Kasai Mari, Hashiguchi Yasunori, Ichimura Tomoyuki, Yasui Tomoyo, Sumi Toshiyuki

    MOLECULAR AND CLINICAL ONCOLOGY   6 ( 3 )   373 - 376   2017.03( ISSN:2049-9450

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.3892/mco.2017.1158

    PubMed

  • Serum CA19-9 as a tumor marker in patients with endometrial cancer Reviewed

    Hashiguchi Y., Kasai M., Fukuda T., Ichimura T., Yasui T., Sumi T.

    EUROPEAN JOURNAL OF CANCER   72   S88 - S88   2017.02( ISSN:0959-8049

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  • Serum CA19-9 as a tumor marker in patients with endometrial cancer Reviewed

    Hashiguchi Y, Kasai M, Fukuda T, Ichimura T, Yasui T, Sumi T

    EUROPEAN JOURNAL OF CANCER   72   S88 - S88   2017.02( ISSN:0959-8049

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    Publishing type:Research paper (scientific journal)  

  • Malignant melanoma Reviewed

    ICHIMURA Tomoyuki

    THE OBSTETRICAL GYNECOLOGICAL SOCIETY OF KINKI DISTRICT JAPAN, ADVANCES IN OBSTETRICS AND GYNECOLOGY   69 ( 1 )   60 - 62   2017( ISSN:0370-8446

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    Publishing type:Research paper (scientific journal)   Kind of work:Single Work  

    DOI: 10.11437/sanpunosinpo.69.60

    CiNii Article

  • A retrospective study of the risk factors of lymphocyst in our hospital Reviewed

    KASAI Mari, SUMI Toshiyuki, WADA Takuma, KAWANISHI Masaru, TASAKA Reiko, IMAI Kenji, FUKUDA Takeshi, HASHIGUCHI Yasunori, ICHIMURA Tomoyuki, YASUI Tomoyo

    THE OBSTETRICAL GYNECOLOGICAL SOCIETY OF KINKI DISTRICT JAPAN, ADVANCES IN OBSTETRICS AND GYNECOLOGY   69 ( 3 )   318 - 320   2017( ISSN:0370-8446

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.11437/sanpunosinpo.69.318

    CiNii Article

  • Realistic fear of cervical cancer risk in Japan depending on birth year Reviewed

    Yagi Asami, Ueda Yutaka, Egawa-Takata Tomomi, Tanaka Yusuke, Nakae Ruriko, Morimoto Akiko, Terai Yoshito, Ohmichi Masahide, Ichimura Tomoyuki, Sumi Toshiyuki, Murata Hiromi, Okada Hidetaka, Nakai Hidekatsu, Mandai Masaki, Matsuzaki Shinya, Kobayashi Eiji, Yoshino Kiyoshi, Kimura Tadashi, Saito Junko, Hori Yumiko, Morii Eiichi, Nakayama Tomio, Suzuki Yukio, Motoki Yoko, Sukegawa Akiko, Asai-Sato Mikiko, Miyagi Etsuko, Yamaguchi Manako, Kudo Risa, Adachi Sosuke, Sekine Masayuki, Enomoto Takayuki, Horikoshi Yorihiko, Takagi Tetsu, Shimura Kentaro

    HUMAN VACCINES & IMMUNOTHERAPEUTICS   13 ( 7 )   1700 - 1704   2017( ISSN:2164-5515

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1080/21645515.2017.1292190

    PubMed

  • A retrospective study of the risk factors of lymphocyst in our hospital

    KASAI Mari, WADA Takuma, KAWANISHI Masaru, TASAKA Reiko, IMAI Kenji, FUKUDA Takeshi, HASHIGUCHI Yasunori, ICHIMURA Tomoyuki, YASUI Tomoyo, SUMI Toshiyuki

    ADVANCES IN OBSTETRICS AND GYNECOLOGY   69 ( 3 )   318 - 320   2017( ISSN:03708446

  • Malignant melanoma Reviewed

    ICHIMURA Tomoyuki

    ADVANCES IN OBSTETRICS AND GYNECOLOGY   69 ( 1 )   60 - 62   2017( ISSN:03708446

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.11437/sanpunosinpo.69.60

    CiNii Article

  • 20歳の日本人における子宮頸癌検診受診率改善を目的に枚方市で実施されたプロジェクト 自分の娘に子宮頸癌検診を勧める気を親に起こさせる(Project conducted in Hirakata to improve cervical cancer screening rates in 20-year-old Japanese: Influencing parents to recommend that their daughters undergo cervical cancer screening) Reviewed

    Yagi Asami, Ueda Yutaka, Egawa-Takata Tomomi, Tanaka Yusuke, Terai Yoshito, Ohmichi Masahide, Ichimura Tomoyuki, Sumi Toshiyuki, Murata Hiromi, Okada Hidetaka, Nakai Hidekatsu, Mandai Masaki, Matsuzaki Shinya, Kobayashi Eiji, Yoshino Kiyoshi, Kimura Tadashi, Saito Junko, Hori Yumiko, Morii Eiichi, Nakayama Tomio, Suzuki Yukio, Motoki Yoko, Sukegawa Akiko, Asai-Sato Mikiko, Miyagi Etsuko, Yamaguchi Manako, Kudo Risa, Adachi Sosuke, Sekine Masayuki, Enomoto Takayuki, Horikoshi Yorihiko, Takagi Tetsu, Shimura Kentaro

    John Wiley & Sons Australia, Ltd The Journal of Obstetrics and Gynaecology Research   42 ( 12 )   1802 - 1807   2016.12( ISSN:1341-8076

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    Publishing type:Research paper (scientific journal)  

    親が自分の20歳の娘に子宮頸癌検診を勧める意思を効果的に惹起する方法について検討した。20歳の娘と同居している親を対象とした。2013年度に彼らの娘に子宮頸癌検診の無料クーポンを郵送してから数ヵ月後に通知葉書を郵送した。2014年度には、対象となった親に、子宮頸癌に関する情報が記載されたパンフレットと娘に見せるための子宮頸癌に関する漫画を郵送し、自分の娘に子宮頸癌検診を進めるよう要請した。2013年度および2014年度の検診受診率を比較した。2014年度に親にパンフレットを郵送した20歳女性の子宮頸癌検診受診率は、2013年度に簡素な通知葉書のみを郵送した女性より有意に高かった。2014年度全体で見ると、20歳女性の全検診受診率は、2013年度より有意に増加した。20歳の娘を持つ親に対して、娘に初めての子宮頸癌検診を勧める気を起こさせることは可能であった。

  • Project conducted in Hirakata to improve cervical cancer screening rates in 20-year-old Japanese: Influencing parents to recommend that their daughters undergo cervical cancer screening Reviewed

    Yagi Asami, Ueda Yutaka, Egawa-Takata Tomomi, Tanaka Yusuke, Terai Yoshito, Ohmichi Masahide, Ichimura Tomoyuki, Sumi Toshiyuki, Murata Hiromi, Okada Hidetaka, Nakai Hidekatsu, Mandai Masaki, Matsuzaki Shinya, Kobayashi Eiji, Yoshino Kiyoshi, Kimura Tadashi, Saito Junko, Hori Yumiko, Morii Eiichi, Nakayama Tomio, Suzuki Yukio, Motoki Yoko, Sukegawa Akiko, Asai-Sato Mikiko, Miyagi Etsuko, Yamaguchi Manako, Kudo Risa, Adachi Sosuke, Sekine Masayuki, Enomoto Takayuki, Horikoshi Yorihiko, Takagi Tetsu, Shimura Kentaro

    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH   42 ( 12 )   1802 - 1807   2016.12( ISSN:1341-8076

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/jog.13122

    PubMed

  • 20歳の日本人における子宮頸癌検診受診率改善を目的に枚方市で実施されたプロジェクト 自分の娘に子宮頸癌検診を勧める気を親に起こさせる(Project conducted in Hirakata to improve cervical cancer screening rates in 20-year-old Japanese: Influencing parents to recommend that their daughters undergo cervical cancer screening) Reviewed

    Yagi Asami, Ueda Yutaka, Egawa-Takata Tomomi, Tanaka Yusuke, Terai Yoshito, Ohmichi Masahide, Ichimura Tomoyuki, Sumi Toshiyuki, Murata Hiromi, Okada Hidetaka, Nakai Hidekatsu, Mandai Masaki, Matsuzaki Shinya, Kobayashi Eiji, Yoshino Kiyoshi, Kimura Tadashi, Saito Junko, Hori Yumiko, Morii Eiichi, Nakayama Tomio, Suzuki Yukio, Motoki Yoko, Sukegawa Akiko, Asai-Sato Mikiko, Miyagi Etsuko, Yamaguchi Manako, Kudo Risa, Adachi Sosuke, Sekine Masayuki, Enomoto Takayuki, Horikoshi Yorihiko, Takagi Tet

    John Wiley & Sons Australia, Ltd The Journal of Obstetrics and Gynaecology Research   42 ( 12 )   1802 - 1807   2016.12( ISSN:1341-8076

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    Publishing type:Research paper (scientific journal)  

    親が自分の20歳の娘に子宮頸癌検診を勧める意思を効果的に惹起する方法について検討した。20歳の娘と同居している親を対象とした。2013年度に彼らの娘に子宮頸癌検診の無料クーポンを郵送してから数ヵ月後に通知葉書を郵送した。2014年度には、対象となった親に、子宮頸癌に関する情報が記載されたパンフレットと娘に見せるための子宮頸癌に関する漫画を郵送し、自分の娘に子宮頸癌検診を進めるよう要請した。2013年度および2014年度の検診受診率を比較した。2014年度に親にパンフレットを郵送した20歳女性の子宮頸癌検診受診率は、2013年度に簡素な通知葉書のみを郵送した女性より有意に高かった。2014年度全体で見ると、20歳女性の全検診受診率は、2013年度より有意に増加した。20歳の娘を持つ親に対して、娘に初めての子宮頸癌検診を勧める気を起こさせることは可能であった。

  • Project conducted in Hirakata to improve cervical cancer screening rates in 20-year-old Japanese: Influencing parents to recommend that their daughters undergo cervical cancer screening. Reviewed

    Asami Yagi, Yutaka Ueda, Tomomi Egawa-Takata, Yusuke Tanaka, Yoshito Terai, Masahide Ohmichi, Tomoyuki Ichimura, Toshiyuki Sumi, Hiromi Murata, Hidetaka Okada, Hidekatsu Nakai, Masaki Mandai, Shinya Matsuzaki, Eiji Kobayashi, Kiyoshi Yoshino, Tadashi Kimura, Junko Saito, Yumiko Hori, Eiichi Morii, Tomio Nakayama, Yukio Suzuki, Yoko Motoki, Akiko Sukegawa, Mikiko Asai-Sato, Etsuko Miyagi, Manako Yamaguchi, Risa Kudo, Sosuke Adachi, Masayuki Sekine, Takayuki Enomoto, Yorihiko Horikoshi, Tetsu Takagi, Kentaro Shimura

    The journal of obstetrics and gynaecology research   42 ( 12 )   1802 - 1807   2016.12( ISSN:1341-8076

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    Publishing type:Research paper (scientific journal)   International / domestic magazine:International journal  

    AIM: In Japan, the rate of routine cervical cancer screening is quite low, and the incidence of cervical cancer has recently been increasing. Our objective was to investigate ways to effectively influence parental willingness to recommend that their 20-year-old daughters undergo cervical cancer screening. METHODS: We targeted parents whose 20-year-old daughters were living with them. In fiscal year 2013, as usual, the daughter received a reminder postcard several months after they had received a free coupon for cervical cancer screening. In fiscal year 2014, the targeted parents received a cervical cancer information leaflet, as well as a cartoon about cervical cancer to show to their daughters, with a request that they recommend to their daughter that she undergo cervical cancer screening. The subsequent screening rates for fiscal years 2013 and 2014 were compared. RESULTS: The cervical cancer screening rate of 20-year-old women whose parents received the information packet in fiscal year 2014 was significantly higher than for the women who, in fiscal year 2013, received only a simple reminder postcard (P < 0.001). As a result, the total screening rate for 20-year-old women for the whole of the 2014 fiscal year was significantly increased over 2013 (P < 0.001). CONCLUSION: For the first time, we have shown that the parents of 20-year-old daughters can be motivated to recommend that their daughters receive their first cervical cancer screening. This was achieved by sending a cervical cancer information leaflet and a cartoon about cervical cancer for these parents to show to their daughters. This method was significantly effective for improving cervical cancer screening rates.

    DOI: 10.1111/jog.13122

    PubMed

  • 20歳の日本人における子宮頸癌検診受診率改善を目的に枚方市で実施されたプロジェクト 自分の娘に子宮頸癌検診を勧める気を親に起こさせる(Project conducted in Hirakata to improve cervical cancer screening rates in 20-year-old Japanese: Influencing parents to recommend that their daughters undergo cervical cancer screening)

    Yagi Asami, Ueda Yutaka, Egawa-Takata Tomomi, Tanaka Yusuke, Terai Yoshito, Ohmichi Masahide, Ichimura Tomoyuki, Sumi Toshiyuki, Murata Hiromi, Okada Hidetaka, Nakai Hidekatsu, Mandai Masaki, Matsuzaki Shinya, Kobayashi Eiji, Yoshino Kiyoshi, Kimura Tadashi, Saito Junko, Hori Yumiko, Morii Eiichi, Nakayama Tomio, Suzuki Yukio, Motoki Yoko, Sukegawa Akiko, Asai-Sato Mikiko, Miyagi Etsuko, Yamaguchi Manako, Kudo Risa, Adachi Sosuke, Sekine Masayuki, Enomoto Takayuki, Horikoshi Yorihiko, Takagi Tetsu, Shimura Kentaro

    The Journal of Obstetrics and Gynaecology Research   42 ( 12 )   1802 - 1807   2016.12( ISSN:1341-8076

     More details

    親が自分の20歳の娘に子宮頸癌検診を勧める意思を効果的に惹起する方法について検討した。20歳の娘と同居している親を対象とした。2013年度に彼らの娘に子宮頸癌検診の無料クーポンを郵送してから数ヵ月後に通知葉書を郵送した。2014年度には、対象となった親に、子宮頸癌に関する情報が記載されたパンフレットと娘に見せるための子宮頸癌に関する漫画を郵送し、自分の娘に子宮頸癌検診を進めるよう要請した。2013年度および2014年度の検診受診率を比較した。2014年度に親にパンフレットを郵送した20歳女性の子宮頸癌検診受診率は、2013年度に簡素な通知葉書のみを郵送した女性より有意に高かった。2014年度全体で見ると、20歳女性の全検診受診率は、2013年度より有意に増加した。20歳の娘を持つ親に対して、娘に初めての子宮頸癌検診を勧める気を起こさせることは可能であった。

  • Molecular Pathology and Novel Clinical Therapy for Uterine Leiomyosarcoma Reviewed

    Hayashi Takuma, Kawano Miki, Ichimura Tomoyuki, Ida Koichi, Ando Hirofumi, Zharhary Dorit, Kanai Yae, Aburatani Hiroyuki, Tonegawa Susumu, Shiozawa Tanri, Yaegashi Nobuo, Konishi Ikuo

    ANTICANCER RESEARCH   36 ( 10 )   4997 - 5007   2016.10( ISSN:0250-7005

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.21873/anticanres.11068

    PubMed

  • 子宮頸癌スクリーニングに関する日本の母親の態度は、娘に対する子宮頸癌スクリーニングを推奨する意向と相関する(Mothers' attitudes in Japan regarding cervical cancer screening correlates with intention to recommend cervical cancer screening for daughters) Reviewed

    Egawa-Takata Tomomi, Ueda Yutaka, Tanaka Yusuke, Morimoto Akiko, Kubota Satoshi, Yagi Asami, Terai Yoshito, Ohmichi Masahide, Ichimura Tomoyuki, Sumi Toshiyuki, Murata Hiromi, Okada Hidetaka, Nakai Hidekatsu, Mandai Masaki, Yoshino Kiyoshi, Kimura Tadashi, Saito Junko, Kudo Risa, Sekine Masayuki, Enomoto Takayuki, Horikoshi Yorihiko, Takagi Tetsu, Shimura Kentaro

    シュプリンガー・ジャパン(株) International Journal of Clinical Oncology   21 ( 5 )   962 - 968   2016.10( ISSN:1341-9625

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    Publishing type:Research paper (scientific journal)  

    2015年2月20日〜25日にかけて、インターネットによるe-メールで、同居の20歳の娘を持つ母親を対象に、母親の子宮頸癌に対する知識、最近の子宮頸癌スクリーニング(CCS)歴と娘へのCCSに関する助言との関連性について、アンケート調査を実施した。有効回答が得られた618例のデータを用いて解析を行い、2年以内にCCSを受けていた275例をA群、CCSを受けていなかった343例をB群として、アンケートには子宮頸癌、CCSおよびヒトパピロマウイルス(HPV)に関する知識、子宮頸癌および他の癌を含む癌スクリーニングに対する態度についての質問も含まれた。その結果、A群はB群に比べ、子宮頸癌やCCSに関する知識が有意に高く、娘にしばしばCCSを受けるよう勧める傾向にあった。また、A群の娘はB群の娘に比べ、高頻度にHPVワクチン接種を受けており、さらに、本調査で子宮頸癌の情報を知った前後における娘に対するCCSを勧める割合は、A群では68%が78%に、B群では48%が59%に増加したが、いずれもA群の方が高い傾向であった。

  • The retrospective analysis of the patients with positive surgical margin who underwent the uterine cervical conization. Reviewed

    Fukuda T., Wada T., Kawanishi M., Tasaka R., Imai K., Kasai M., Nishimura S., Hashiguchi Y., Ichimura T., Yasui T., Sumi T.

    INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER   26   359 - 359   2016.10( ISSN:1048-891X

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  • Serum carcinoembryonic antigen as a tumour marker in patients with endometrial cancer Reviewed

    Hashiguchi Y., Kasai M., Fukuda T., Ichimura T., Yasui T., Sumi T.

    CURRENT ONCOLOGY   23 ( 5 )   E439 - E442   2016.10( ISSN:1198-0052

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.3747/co.23.3153

  • Mothers' attitudes in Japan regarding cervical cancer screening correlates with intention to recommend cervical cancer screening for daughters Reviewed

    Egawa-Takata Tomomi, Ueda Yutaka, Tanaka Yusuke, Morimoto Akiko, Kubota Satoshi, Yagi Asami, Terai Yoshito, Ohmichi Masahide, Ichimura Tomoyuki, Sumi Toshiyuki, Murata Hiromi, Okada Hidetaka, Nakai Hidekatsu, Mandai Masaki, Yoshino Kiyoshi, Kimura Tadashi, Saito Junko, Kudo Risa, Sekine Masayuki, Enomoto Takayuki, Horikoshi Yorihiko, Takagi Tetsu, Shimura Kentaro

    INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY   21 ( 5 )   962 - 968   2016.10( ISSN:1341-9625

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s10147-016-0970-4

    PubMed

  • Molecular pathology and novel clinical therapy for uterine leiomyosarcoma Reviewed

    Takuma Hayashi, Miki Kawano, Tomoyuki Ichimura, Koichi Ida, Hirofumi Ando, Dorit Zharhary, Yae Kanai, Hiroyuki Aburatani, Susumu Tonegawa, Tanri Shiozawa, Nobuo Yaegashi, Ikuo Konishi

    Anticancer Research   36 ( 10 )   4997 - 5007   2016.10( ISSN:0250-7005

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    Publishing type:Research paper (scientific journal)  

    Patients with uterine leiomyosarcoma (LMS) typically present with vaginal bleeding, pain, and a pelvic mass, with atypical presentations of hypercalcemia and eosinophilia also being reported. Radiographic evaluation with combined positron-emission tomography/computed tomography may assist in diagnosis and surveillance in women with uterine LMS
    these are commonly used with stage and tumour grade as prognostic indicators and a recently developed risk-assessment index to predict disease-specific survival. Recent studies have shown that the addition of adjuvant therapy after surgical management does not seem to improve survival, and ovarian preservation does not appear to negatively impact outcome. Experimentally, it is noteworthy that proteasome subunit beta 9 (PSMB9)/1i-deficient mice exhibit spontaneous development of uterine LMS, with a disease prevalence of ~37% by 12 months of age. Furthermore, a recent report showed the loss of ability to induce PSMB9/1i expression, that is up-regulated by interferon-(IFN), in human uterine LMS tissues. Here, we reviewed human uterine LMS for genetic mutations in the IFN signal cascade, and found serious mutations in three genes, Janus activated kinase 1 (JAK1), signal transducer and activator of transcription 1 (STAT1) and PSMB9/1i promoter regions. Moreover, molecular experiments demonstrated differential expression of cyclin E and P27/KIP1, that regulate cell-cycle G1 arrest via PSMB9/1i expression. The discovery of this mutational activation of a key cell-signalling pathway may provide new targets for diagnostic approaches and therapeutic intervention.

    DOI: 10.21873/anticanres.11068

    PubMed

  • The retrospective analysis of the patients with positive surgical margin who underwent the uterine cervical conization. Reviewed

    Fukuda T, Wada T, Kawanishi M, Tasaka R, Imai K, Kasai M, Nishimura S, Hashiguchi Y, Ichimura T, Yasui T, Sumi T

    INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER   26   359 - 359   2016.10( ISSN:1048-891X

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  • Serum carcinoembryonic antigen as a tumour marker in patients with endometrial cancer Reviewed

    Yasunori Hashiguchi, M. Kasai, T. Fukuda, T. Ichimura, T. Yasui, T. Sumi

    Current Oncology   23 ( 5 )   e439 - e442   2016.10( ISSN:1198-0052

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    Background No potential tumour markers have been validated for prognosis in endometrial cancer. However, carcinoembryonic antigen (cea) is one of the most widely used tumour markers in various types of cancer. Although cea expression in endometrial cancer has been investigated, its prognostic value remains controversial, and no studies have investigated serum cea levels in large case series. In the present study, we investigated diagnostic and prognostic applications of serum cea for endometrial cancer. Methods This prospective study was approved by our Institutional Review Board. Between January 2006 and December 2012, serum cea was measured prospectively in 215 patients with endometrial cancer and was subsequently measured during treatment and at scheduled follow-up examinations in patients with elevated baseline serum cea. Results During the study period, 215 patients (142 stage i, 19 stage ii, 32 stage iii, 22 stage iv) were treated for endometrial cancer. By the time of last follow-up, 52 had relapsed (24.2%), and the median follow-up duration was 45 months (range: 1–95 months). Elevated serum cea was identified in 25 patients (11.6%) and was associated with histologic type (p = 0.04), histologic grade (p = 0.03), and myometrial invasion depth (p = 0.01). Elevated serum cea was not related to clinical stage, lymph node metastasis, distant metastasis, age, menopausal status, or body mass index. Relapse of disease was related to elevated serum cea (p = 0.006). Conclusions Serum cea is a potential prognostic indicator for endometrial cancer.

    DOI: 10.3747/co.23.3153

    PubMed

  • Mothers' attitudes in Japan regarding cervical cancer screening correlates with intention to recommend cervical cancer screening for daughters. Reviewed

    Tomomi Egawa-Takata, Yutaka Ueda, Yusuke Tanaka, Akiko Morimoto, Satoshi Kubota, Asami Yagi, Yoshito Terai, Masahide Ohmichi, Tomoyuki Ichimura, Toshiyuki Sumi, Hiromi Murata, Hidetaka Okada, Hidekatsu Nakai, Masaki Mandai, Kiyoshi Yoshino, Tadashi Kimura, Junko Saito, Risa Kudo, Masayuki Sekine, Takayuki Enomoto, Yorihiko Horikoshi, Tetsu Takagi, Kentaro Shimura

    International journal of clinical oncology   21 ( 5 )   962 - 968   2016.10( ISSN:1341-9625

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    Publishing type:Research paper (scientific journal)   International / domestic magazine:Domestic journal  

    BACKGROUND: Cervical cancer and its precancerous lesions caused by human papilloma virus (HPV) are steadily increasing in women in Japan. In comparison with women in other resource-rich countries, young women in Japan have a dismally low screening rate for cervical cancer. Our preliminary research has shown that 20-year-old women in Japan usually ask their mothers for advice regarding their initial cervical cancer screening. The objective of our current research is to determine the social factors among mothers in Japan that are causing them to give advice to their daughters regarding the HPV vaccine and cervical cancer screening. METHODS: The survey's targets were mothers who had 20-year-old daughters. We recruited respondents from the roster of a commercial internet survey panel. We analyzed for correlations between a mother's knowledge concerning cervical cancer, her recent cancer screening history, and the advice she gave to her daughter regarding cervical cancer screening. RESULTS: We obtained 618 valid answers to the survey. Compared with mothers who did not get screening, mothers who had cervical cancer screening had significantly more knowledge about cervical cancer and its screening (p < 0.05). The daughters of mothers with recent screening had received HPV vaccination more often than those of mothers without recent screening (p = 0.018). Mothers with recent screening histories tended more often to encourage their daughters to have cervical cancer screening (p < 0.05). When mothers were properly educated concerning cervical cancer and its screening, they were significantly more likely than before to recommend that their daughters have it (p < 0.0001). CONCLUSIONS: In young Japanese women, given the important role their mothers have in their lives, it is probable that we could improve their cervical cancer screening rate significantly by giving their mothers better medical information, and a chance to experience cervical cancer screening for themselves.

    DOI: 10.1007/s10147-016-0970-4

    PubMed

  • 子宮頸癌スクリーニングに関する日本の母親の態度は、娘に対する子宮頸癌スクリーニングを推奨する意向と相関する(Mothers' attitudes in Japan regarding cervical cancer screening correlates with intention to recommend cervical cancer screening for daughters)

    Egawa-Takata Tomomi, Ueda Yutaka, Tanaka Yusuke, Morimoto Akiko, Kubota Satoshi, Yagi Asami, Terai Yoshito, Ohmichi Masahide, Ichimura Tomoyuki, Sumi Toshiyuki, Murata Hiromi, Okada Hidetaka, Nakai Hidekatsu, Mandai Masaki, Yoshino Kiyoshi, Kimura Tadashi, Saito Junko, Kudo Risa, Sekine Masayuki, Enomoto Takayuki, Horikoshi Yorihiko, Takagi Tetsu, Shimura Kentaro

    International Journal of Clinical Oncology   21 ( 5 )   962 - 968   2016.10( ISSN:1341-9625

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    2015年2月20日〜25日にかけて、インターネットによるe-メールで、同居の20歳の娘を持つ母親を対象に、母親の子宮頸癌に対する知識、最近の子宮頸癌スクリーニング(CCS)歴と娘へのCCSに関する助言との関連性について、アンケート調査を実施した。有効回答が得られた618例のデータを用いて解析を行い、2年以内にCCSを受けていた275例をA群、CCSを受けていなかった343例をB群として、アンケートには子宮頸癌、CCSおよびヒトパピロマウイルス(HPV)に関する知識、子宮頸癌および他の癌を含む癌スクリーニングに対する態度についての質問も含まれた。その結果、A群はB群に比べ、子宮頸癌やCCSに関する知識が有意に高く、娘にしばしばCCSを受けるよう勧める傾向にあった。また、A群の娘はB群の娘に比べ、高頻度にHPVワクチン接種を受けており、さらに、本調査で子宮頸癌の情報を知った前後における娘に対するCCSを勧める割合は、A群では68%が78%に、B群では48%が59%に増加したが、いずれもA群の方が高い傾向であった。

  • 子宮頸癌スクリーニングに関する日本の母親の態度は、娘に対する子宮頸癌スクリーニングを推奨する意向と相関する(Mothers' attitudes in Japan regarding cervical cancer screening correlates with intention to recommend cervical cancer screening for daughters) Reviewed

    Egawa-Takata Tomomi, Ueda Yutaka, Tanaka Yusuke, Morimoto Akiko, Kubota Satoshi, Yagi Asami, Terai Yoshito, Ohmichi Masahide, Ichimura Tomoyuki, Sumi Toshiyuki, Murata Hiromi, Okada Hidetaka, Nakai Hidekatsu, Mandai Masaki, Yoshino Kiyoshi, Kimura Tadashi, Saito Junko, Kudo Risa, Sekine Masayuki, Enomoto Takayuki, Horikoshi Yorihiko, Takagi Tetsu, Shimura Kentaro

    シュプリンガー・ジャパン(株) International Journal of Clinical Oncology   21 ( 5 )   962 - 968   2016.10( ISSN:1341-9625

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    Publishing type:Research paper (scientific journal)  

    2015年2月20日〜25日にかけて、インターネットによるe-メールで、同居の20歳の娘を持つ母親を対象に、母親の子宮頸癌に対する知識、最近の子宮頸癌スクリーニング(CCS)歴と娘へのCCSに関する助言との関連性について、アンケート調査を実施した。有効回答が得られた618例のデータを用いて解析を行い、2年以内にCCSを受けていた275例をA群、CCSを受けていなかった343例をB群として、アンケートには子宮頸癌、CCSおよびヒトパピロマウイルス(HPV)に関する知識、子宮頸癌および他の癌を含む癌スクリーニングに対する態度についての質問も含まれた。その結果、A群はB群に比べ、子宮頸癌やCCSに関する知識が有意に高く、娘にしばしばCCSを受けるよう勧める傾向にあった。また、A群の娘はB群の娘に比べ、高頻度にHPVワクチン接種を受けており、さらに、本調査で子宮頸癌の情報を知った前後における娘に対するCCSを勧める割合は、A群では68%が78%に、B群では48%が59%に増加したが、いずれもA群の方が高い傾向であった。

  • Development of an efficient strategy to improve HPV immunization coverage in Japan Reviewed

    Yagi Asami, Ueda Yutaka, Egawa-Takata Tomomi, Tanaka Yusuke, Morimoto Akiko, Terai Yoshito, Ohmichi Masahide, Ichimura Tomoyuki, Sumi Toshiyuki, Murata Hiromi, Okada Hidetaka, Nakai Hidekatsu, Mandai Masaki, Yoshino Kiyoshi, Kimura Tadashi, Saito Junko, Kudoh Risa, Sekine Masayuki, Enomoto Takayuki, Hirai Kei, Horikoshi Yorihiko, Takagi Tetsu, Shimura Kentaro

    BMC PUBLIC HEALTH   16 ( 1 )   1013   2016.09( ISSN:1471-2458

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s12889-016-3676-7

    PubMed

  • Development of an efficient strategy to improve HPV immunization coverage in Japan Reviewed

    Yagi Asami, Ueda Yutaka, Egawa-Takata Tomomi, Tanaka Yusuke, Morimoto Akiko, Terai Yoshito, Ohmichi Masahide, Ichimura Tomoyuki, Sumi Toshiyuki, Murata Hiromi, Okada Hidetaka, Nakai Hidekatsu, Mandai Masaki, Yoshino Kiyoshi, Kimura Tadashi, Saito Junko, Kudoh Risa, Sekine Masayuki, Enomoto Takayuki, Hirai Kei, Horikoshi Yorihiko, Takagi Tetsu, Shimura Kentaro

    BMC PUBLIC HEALTH   16 ( 1 )   1013   2016.09( ISSN:1471-2458

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s12889-016-3676-7

    PubMed

  • Pharmacokinetic analyses of carboplatin in a patient with cancer of the fallopian tubes undergoing hemodialysis: A case report Reviewed

    Wada Takuma, Fukuda Takeshi, Kawanishi Masaru, Tasaka Reiko, Imai Kenji, Yamauchi Makoto, Kasai Mari, Hashiguchi Yasunori, Ichimura Tomoyuki, Yasui Tomoyo, Sumi Toshiyuki

    BIOMEDICAL REPORTS   5 ( 2 )   199 - 202   2016.08( ISSN:2049-9434

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.3892/br.2016.714

    PubMed

  • 後腹膜線維症による両側水腎症により発見された子宮頸癌の1例 Reviewed

    高瀬 亜紀, 市村 友季, 中川 倫子, 村上 誠, 安井 智代, 角 俊幸

    「産婦人科の進歩」編集室 産婦人科の進歩   68 ( 3 )   243 - 247   2016.08( ISSN:0370-8446

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    症例は35歳(未経妊)で、嘔吐と右側腹部痛で近医CTにて両側水腎症を認め、両側尿管カテーテル留置で腎機能は改善せず、当院泌尿器科で両側腎瘻造設術後に当科紹介となった。頸部細胞診はSCC疑いで、コルポスコープで脆弱な易出血性の隆起病変を認め、同部位の生検では粘液性腺癌であった。MRIで子宮体下部に3cm大の筋腫様結節、左卵巣に2〜3cm大のT1・T2強調とも高信号の内膜症性嚢胞様病変を認め、子宮頸部腺癌の診断で広汎子宮全摘術、両側付属器摘出術を行った。術中に後腹膜腔は線維化が著明で尿管は硬化し、後腹膜線維症の所見であった。病理所見で頸部に5mm大の腫瘤、子球体下部に子宮筋腫結節を認め、診断は頸部腺癌で、子宮傍組織浸潤と両側卵巣、骨盤・傍大動脈リンパ節に転移を認めた。洗浄腹水細胞診は腺癌で尿管周囲組織にも転移を認め、後腹膜線維症による水腎症合併の子宮頸部腺癌と診断し、術後化学療法を行ったが、初診17ヵ月後に原病死した。

  • Pharmacokinetic analyses of carboplatin in a patient with cancer of the fallopian tubes undergoing hemodialysis: A case report Reviewed

    Takuma Wada, Takeshi Fukuda, Masaru Kawanishi, Reiko Tasaka, Kenji Imai, Makoto Yamauchi, Mari Kasai, Yasunori Hashiguchi, Tomoyuki Ichimura, Tomoyo Yasui, Toshiyuki Sumi

    Biomedical Reports   5 ( 2 )   199 - 202   2016.08( ISSN:2049-9434

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    Opportunities for patients undergoing hemodialysis to receive chemotherapy are increasing. A combination of paclitaxel and carboplatin (TC) is first-line chemotherapy in patients with Müllerian cancer. However, the optimal dose and time interval between the end of carboplatin administration and initiation of hemodialysis remains to be elucidated. TC was administered to a patient with fallopian tube cancer undergoing hemodialysis. The paclitaxel regimen was determined to be 135 mg/m2 (total of 210 mg) over 3 h. After paclitaxel administration, 125 mg of carboplatin was administered over 1 h to achieve a target area under the concentration-time curve (AUC) of 5.0 mg•min/ml using the Calvert formula. The time interval between the end of carboplatin administration and hemodialysis initiation was 1 h at the first cycle, 16 h at the second cycle and 20 h at the third cycle, and the AUC obtained was 2.86, 4.16 and 6.0 mg•min/ml, respectively. The desired AUC of free platinum was demonstrated and only mild side effects were observed at the third cycle. Therefore, hemodialysis was initiated 20 h after completion of carboplatin infusion at cycles 4-6. The total chemotherapy planned was completed without severe adverse events. Measurement of the concentration of free platinum subsequent to administration is useful for determination of the optimal dose of carboplatin and time interval following administration to obtain an adequate AUC. The present study suggests that carboplatin can be administered to a patient undergoing hemodialysis, and that an adequate interval between the end of carboplatin administration and hemodialysis initiation may be ~20 h.

    DOI: 10.3892/br.2016.714

    PubMed

  • 後腹膜線維症による両側水腎症により発見された子宮頸癌の1例

    高瀬 亜紀, 市村 友季, 中川 倫子, 村上 誠, 安井 智代, 角 俊幸

    産婦人科の進歩   68 ( 3 )   243 - 247   2016.08( ISSN:0370-8446

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    症例は35歳(未経妊)で、嘔吐と右側腹部痛で近医CTにて両側水腎症を認め、両側尿管カテーテル留置で腎機能は改善せず、当院泌尿器科で両側腎瘻造設術後に当科紹介となった。頸部細胞診はSCC疑いで、コルポスコープで脆弱な易出血性の隆起病変を認め、同部位の生検では粘液性腺癌であった。MRIで子宮体下部に3cm大の筋腫様結節、左卵巣に2〜3cm大のT1・T2強調とも高信号の内膜症性嚢胞様病変を認め、子宮頸部腺癌の診断で広汎子宮全摘術、両側付属器摘出術を行った。術中に後腹膜腔は線維化が著明で尿管は硬化し、後腹膜線維症の所見であった。病理所見で頸部に5mm大の腫瘤、子球体下部に子宮筋腫結節を認め、診断は頸部腺癌で、子宮傍組織浸潤と両側卵巣、骨盤・傍大動脈リンパ節に転移を認めた。洗浄腹水細胞診は腺癌で尿管周囲組織にも転移を認め、後腹膜線維症による水腎症合併の子宮頸部腺癌と診断し、術後化学療法を行ったが、初診17ヵ月後に原病死した。

  • 後腹膜線維症による両側水腎症により発見された子宮頸癌の1例 Reviewed

    高瀬 亜紀, 市村 友季, 中川 倫子, 村上 誠, 安井 智代, 角 俊幸

    「産婦人科の進歩」編集室 産婦人科の進歩   68 ( 3 )   243 - 247   2016.08( ISSN:0370-8446

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    Publishing type:Research paper (scientific journal)  

    症例は35歳(未経妊)で、嘔吐と右側腹部痛で近医CTにて両側水腎症を認め、両側尿管カテーテル留置で腎機能は改善せず、当院泌尿器科で両側腎瘻造設術後に当科紹介となった。頸部細胞診はSCC疑いで、コルポスコープで脆弱な易出血性の隆起病変を認め、同部位の生検では粘液性腺癌であった。MRIで子宮体下部に3cm大の筋腫様結節、左卵巣に2〜3cm大のT1・T2強調とも高信号の内膜症性嚢胞様病変を認め、子宮頸部腺癌の診断で広汎子宮全摘術、両側付属器摘出術を行った。術中に後腹膜腔は線維化が著明で尿管は硬化し、後腹膜線維症の所見であった。病理所見で頸部に5mm大の腫瘤、子球体下部に子宮筋腫結節を認め、診断は頸部腺癌で、子宮傍組織浸潤と両側卵巣、骨盤・傍大動脈リンパ節に転移を認めた。洗浄腹水細胞診は腺癌で尿管周囲組織にも転移を認め、後腹膜線維症による水腎症合併の子宮頸部腺癌と診断し、術後化学療法を行ったが、初診17ヵ月後に原病死した。

  • Serum Sialyl-Tn (STN) as a Tumor Marker in Patients with Endometrial Cancer Reviewed

    Hashiguchi Yasunori, Kasai Mari, Fukuda Takeshi, Ichimura Tomoyuki, Yasui Tomoyo, Sumi Toshiyuki

    PATHOLOGY & ONCOLOGY RESEARCH   22 ( 3 )   501 - 504   2016.07( ISSN:1219-4956

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s12253-015-0030-9

    PubMed

  • Serum Sialyl-Tn (STN) as a Tumor Marker in Patients with Endometrial Cancer Reviewed

    Yasunori Hashiguchi, Mari Kasai, Takeshi Fukuda, Tomoyuki Ichimura, Tomoyo Yasui, Toshiyuki Sumi

    Pathology and Oncology Research   22 ( 3 )   501 - 4   2016.07( ISSN:1219-4956

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    There are no potential tumor markers validated for prognosis of endometrial cancer. However, sialyl Tn (STN) is a carbohydrate antigen that is associated with the production of mucin, which reportedly plays important roles in carcinogenesis. Although STN expression in endometrial cancer has been investigated, its prognostic value remains controversial and no studies have investigated serum STN levels in large case series. In this study, we investigated diagnostic and prognostic applications of serum STN for endometrial cancer. Between January 2006 and December 2012, serum STN levels were examined prospectively in patients with endometrial cancer. A total of 146 patients (stage I, 98
    stage II, 15
    stage III, 17
    stage IV, 16) were treated for endometrial cancer. The median age was 60 years (28–83). Subsequently 29 patients (19.9%) relapsed at the time of the last follow-up and the median follow-up time was 44 months (1–83). Elevated serum STN levels were identified in 36 patients (24.7%) and were associated with histological grade (p = 0.02) and lymph node metastasis (p = 0.006). Elevated serum STN levels were not related to histological types, clinical stages, myometrial invasions, distant metastases, age, menopausal status, body mass index, or relapse. Among the 36 patients with elevated serum STN levels, 33 (91.7%) achieved remission and serum STN levels returned to the normal range. Seven patients (21.2%) with elevated serum STN levels at baseline relapsed and their serum STN levels were again elevated. Serum STN levels are a potential prognostic indicator for endometrial cancer.

    DOI: 10.1007/s12253-015-0030-9

    PubMed

  • IS-MW-4-3 Expression of UCP2 predicts the efficacy of neoadjuvant chemotherapy for locally advanced uterine cervical cancer(Group 4 Oncology 2,International Session Mini Workshop) :

    ImaiKenji, FukudaTakeshi, WadaTakuma, KawanishiMasaru, TasakaReiko, YamauchiMakoto, KasaiMari, HashiguchiYasunori, IchimuraTomoyuki, YasuiTomoyo, SumiToshiyuki

    68 ( 2 )   473   2016.02

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  • ISP-4-5 The retrospective analysis of the patients with positive surgical margin who underwent the uterine cervical conization(Group 4 Cervical Cancer 3,International Session Poster) :

    TasakaReiko, FukudaTakeshi, WadaTakuma, KawanishiMasaru, ImaiKenji, YamauchiMakoto, KasaiMari, HashiguchiYasunori, IchimuraTomoyuki, YasuiTomoyo, SumiToshiyuki

    68 ( 2 )   488   2016.02

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  • ISP-16-9 The experience of the treatment of the epithelial ovarian cancer with bevacizumab(Group 16 Ovarian Cancer 5,International Session Poster) :

    WadaTakuma, FukudaTakeshi, KawanishiMasaru, ImaiKenji, TasakaReiko, YamauchiMakoto, KasaiMari, HashiguchiYasunori, IchimuraTomoyuki, YasuiTomoyo, SumiToshiyuki

    68 ( 2 )   525   2016.02

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  • ISP-14-1 Pulmonary type of small cell carcinoma of the ovary : a case report(Group 14 Ovarian Cancer 3,International Session Poster) :

    KawanishiMasaru, FukudaTakeshi, WadaTakuma, ImaiKenji, TasakaReiko, YamauchiMakoto, KasaiMari, HashiguchiYasunori, IchimuraTomoyuki, YasuiTomoyo, SumiToshiyuki

    68 ( 2 )   516   2016.02

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  • 私たちが行う針生検 ; 子宮筋層病変生検研究会からの報告 : その手技から診断まで(子宮筋層・内膜症病変生検研究会,ハンズオンセミナー,公益社団法人日本産科婦人科学会第68回学術講演会)

    市村友季

    日本産科婦人科學會雜誌   68 ( 2 )   451   2016.02

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  • 私たちが行う針生検 ; 子宮筋層病変生検研究会からの報告 : その手技から診断まで(子宮筋層・内膜症病変生検研究会,ハンズオンセミナー,公益社団法人日本産科婦人科学会第68回学術講演会) Reviewed

    市村 友季

    日本産科婦人科学会 日本産科婦人科學會雜誌   68 ( 2 )   2016

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    CiNii Article

  • A case of cervical cancer complicated with bilateral hydronephrosis caused by retroperitoneal fibrosis Reviewed

    TAKASE Aki, ICHIMURA Tomoyuki, NAKAGAWA Tomoko, MURAKAMI Makoto, YASUI Tomoyo, SUMI Toshiyuki

    THE OBSTETRICAL GYNECOLOGICAL SOCIETY OF KINKI DISTRICT JAPAN, ADVANCES IN OBSTETRICS AND GYNECOLOGY   68 ( 3 )   243 - 247   2016( ISSN:0370-8446

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    <p>Retroperitoneal fibrosis is characterized by fibrosis of retroperitoneal cavity and causes the ureteral stricture and obstruction, and hydronephrosis is caused by impaired ureteral peristalsis. We report a case of cervical adenocarcinoma, which was diagnosed after detection of bilateral hydronephrosis caused by retroperitoneal fibrosis. The patient was a 35-year-old non-gravida woman with no past history. She was reffered to another physician, with a compliant of right abdominal pain. Bilateral hydronephrosis and high serum creatinine level (3.8 mg/dl) were detected. She underwent bilateral ureteral stent placement, but renal function did not improve, so she was reffered to the Department of Urology at our hospital. She underwent bilateral nephrostomy and reffered to our Department. No cervical tumor was detected by ultrasonography, but uterine cervix cytology was SCC suspected and colposcopy detected a small tumorous lesion of the cervix. Cervical biopsy was performed and the histology showed mucinous adenocarcinoma. Magnetic resonance imaging revealed no cervical tumor and no lymph node swelling in the pelvis. Computed tomography did not reveal any metastasis. She was diagnosed with cervical cancer stage I B1 and we performed radical hysterectomy and bilateral salpingo-oophorectomy. Intraoperatively, we found marked retroperitoneal fibrosis and harden, inflexible urinary ducts, so retroperitoneal fibrosis was suspected. Macroscopically, there was a mass of 5 mm diameter in the uterine cervix, but no lymph node swelling in the pelvis. Histopathological examination revealed usual-type endocervical adenocarcinoma, with bilateral parametrial invasion, bilateral ovarian metastasis, and retroperitoneal lymph node metastasis, and retroperitoneal infiltrate around bilateral ureters. We considered that this case was cervical adenocarcinoma complicated with bilateral hydronephrosis caused by retroperitoneal fibrosis. She received adjuvant chemotherapy, but she died of the disease 17 months after initial treatment and showed a poor prognosis. This case suggests that we should consider a diagnosis of retroperitoneal fibrosis, when hydronephrosis without obvious organic dysfuncion is detected. [Adv Obstet Gynecol, 68 (3) : 243-247, 2016 (H28.8)]</p>

    DOI: 10.11437/sanpunosinpo.68.243

    CiNii Article

  • Primary mediastinal choriocarcinoma with brain metastasis in a female patient Reviewed

    Kuno I., Matsumoto Y., Kasai M., Fukuda T., Hashiguchi Y., Ichimura T., Yasui T., Sumi T.

    EUROPEAN JOURNAL OF GYNAECOLOGICAL ONCOLOGY   37 ( 2 )   265 - 266   2016( ISSN:0392-2936

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  • Krukenberg tumor in a 18-year-old-female: a rare case Reviewed

    Kuno I., Hashiguchi Y., Kasai M., Fukuda T., Ichimura T., Yasui T., Sumi T.

    EUROPEAN JOURNAL OF GYNAECOLOGICAL ONCOLOGY   37 ( 1 )   139 - 141   2016( ISSN:0392-2936

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  • ISP-4-5 The retrospective analysis of the patients with positive surgical margin who underwent the uterine cervical conization(Group 4 Cervical Cancer 3,International Session Poster) : Reviewed

    Tasaka Reiko, Fukuda Takeshi, Wada Takuma, Kawanishi Masaru, Imai Kenji, Yamauchi Makoto, Kasai Mari, Hashiguchi Yasunori, Ichimura Tomoyuki, Yasui Tomoyo, Sumi Toshiyuki

    日本産科婦人科学会 日本産科婦人科學會雜誌   68 ( 2 )   2016

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    CiNii Article

  • ISP-16-9 The experience of the treatment of the epithelial ovarian cancer with bevacizumab(Group 16 Ovarian Cancer 5,International Session Poster) : Reviewed

    Wada Takuma, Fukuda Takeshi, Kawanishi Masaru, Imai Kenji, Tasaka Reiko, Yamauchi Makoto, Kasai Mari, Hashiguchi Yasunori, Ichimura Tomoyuki, Yasui Tomoyo, Sumi Toshiyuki

    日本産科婦人科学会 日本産科婦人科學會雜誌   68 ( 2 )   2016

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    CiNii Article

  • ISP-14-1 Pulmonary type of small cell carcinoma of the ovary : a case report(Group 14 Ovarian Cancer 3,International Session Poster) : Reviewed

    Kawanishi Masaru, Fukuda Takeshi, Wada Takuma, Imai Kenji, Tasaka Reiko, Yamauchi Makoto, Kasai Mari, Hashiguchi Yasunori, Ichimura Tomoyuki, Yasui Tomoyo, Sumi Toshiyuki

    日本産科婦人科学会 日本産科婦人科學會雜誌   68 ( 2 )   2016

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    CiNii Article

  • IS-MW-4-3 Expression of UCP2 predicts the efficacy of neoadjuvant chemotherapy for locally advanced uterine cervical cancer(Group 4 Oncology 2,International Session Mini Workshop) : Reviewed

    Imai Kenji, Fukuda Takeshi, Wada Takuma, Kawanishi Masaru, Tasaka Reiko, Yamauchi Makoto, Kasai Mari, Hashiguchi Yasunori, Ichimura Tomoyuki, Yasui Tomoyo, Sumi Toshiyuki

    日本産科婦人科学会 日本産科婦人科學會雜誌   68 ( 2 )   2016

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    CiNii Article

  • Primary mediastinal choriocarcinoma with brain metastasis in a female patient Reviewed

    I. Kuno, Y. Matsumoto, M. Kasai, T. Fukuda, Y. Hashiguchi, T. Ichimura, T. Yasui, T. Sumi

    European Journal of Gynaecological Oncology   37 ( 2 )   265 - 266   2016( ISSN:0392-2936

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    Nongestational choriocarcinoma is very rare and carries a poor prognosis in female patients. In this report, the authors present a case of nongestational choriocarcinoma with brain metastasis in a female. A 58-year-old female with intermittent back pain was referred to a private hospital. On examination, a mediastinal tumor and a pancreatic tumor were detected. Endoscopic ultrasound-guided fine needle aspiration biopsy of the tumor was performed for histological evaluation. Pathological diagnosis was difficult because only a small amount of tissue was collected. Head MRI showed multiple metastatic tumors in the brain. The patient was diagnosed with primary mediastinal choriocarcinoma with brain metastasis. She was treated with one course of an etoposide, methotrexate, dactinomycin, cyclophosphamide, and vincristine regimen, but her general condition gradually deteriorated, and she died on day 41. Nongestational choriocarcinoma is drug resistant, whereas gestational choriocarcinoma has better chemotherapeutic sensitivity.

    DOI: 10.12892/ejgo2833.2016

    PubMed

  • Krukenberg tumor in a 18-year-old-female: A rare case Reviewed

    I. Kuno, Y. Hashiguchi, M. Kasai, T. Fukuda, T. Ichimura, T. Yasui, T. Sumi

    European Journal of Gynaecological Oncology   37 ( 1 )   139 - 141   2016( ISSN:0392-2936

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    Background: Krukenberg tumors mostly occur after 40 years. Metastatic ovarian tumors in young age are very rare. Case: A18-yearold female presented with colon cancer which was accompanied by Krukenberg tumor. The present case was a very rare case of metastatic ovarian tumor in very young age. The present patient presented with abdominal pain. On examination, colon tumor was detected and bilateral ovary were almost normal with only slight swelling. During the operation for colon tumor, biopsy of bilateral ovary was performed for histopathological evaluation. Although there were no specific findings in bilateral ovary, microscopic examination revealed poorly differentiated adenocarcinoma, diffusely invading the ovarian parenchyma. Diagnosis of colon cancer was made postoperatively and ovarian Krukenberg tumor was confirmed. Conclusion: In case of suspecting colon cancer even in very young patient with normal ovary, biopsy of ovary should be considered for the diagnosis of Krukenberg tumor.

    DOI: 10.12892/ejgo2779.2016

    PubMed

  • ISP-4-5 The retrospective analysis of the patients with positive surgical margin who underwent the uterine cervical conization(Group 4 Cervical Cancer 3,International Session Poster) : Reviewed

    Tasaka Reiko, Fukuda Takeshi, Wada Takuma, Kawanishi Masaru, Imai Kenji, Yamauchi Makoto, Kasai Mari, Hashiguchi Yasunori, Ichimura Tomoyuki, Yasui Tomoyo, Sumi Toshiyuki

    日本産科婦人科学会 日本産科婦人科學會雜誌   68 ( 2 )   488 - 488   2016( ISSN:0300-9165

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    CiNii Article

  • ISP-16-9 The experience of the treatment of the epithelial ovarian cancer with bevacizumab(Group 16 Ovarian Cancer 5,International Session Poster) : Reviewed

    Wada Takuma, Fukuda Takeshi, Kawanishi Masaru, Imai Kenji, Tasaka Reiko, Yamauchi Makoto, Kasai Mari, Hashiguchi Yasunori, Ichimura Tomoyuki, Yasui Tomoyo, Sumi Toshiyuki

    日本産科婦人科学会 日本産科婦人科學會雜誌   68 ( 2 )   525 - 525   2016( ISSN:0300-9165

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    CiNii Article

  • ISP-14-1 Pulmonary type of small cell carcinoma of the ovary : a case report(Group 14 Ovarian Cancer 3,International Session Poster) : Reviewed

    Kawanishi Masaru, Fukuda Takeshi, Wada Takuma, Imai Kenji, Tasaka Reiko, Yamauchi Makoto, Kasai Mari, Hashiguchi Yasunori, Ichimura Tomoyuki, Yasui Tomoyo, Sumi Toshiyuki

    日本産科婦人科学会 日本産科婦人科學會雜誌   68 ( 2 )   516 - 516   2016( ISSN:0300-9165

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    CiNii Article

  • IS-MW-4-3 Expression of UCP2 predicts the efficacy of neoadjuvant chemotherapy for locally advanced uterine cervical cancer(Group 4 Oncology 2,International Session Mini Workshop) : Reviewed

    Imai Kenji, Fukuda Takeshi, Wada Takuma, Kawanishi Masaru, Tasaka Reiko, Yamauchi Makoto, Kasai Mari, Hashiguchi Yasunori, Ichimura Tomoyuki, Yasui Tomoyo, Sumi Toshiyuki

    日本産科婦人科学会 日本産科婦人科學會雜誌   68 ( 2 )   473 - 473   2016( ISSN:0300-9165

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  • A case of cervical cancer complicated with bilateral hydronephrosis caused by retroperitoneal fibrosis Reviewed

    TAKASE Aki, ICHIMURA Tomoyuki, NAKAGAWA Tomoko, MURAKAMI Makoto, YASUI Tomoyo, SUMI Toshiyuki

    ADVANCES IN OBSTETRICS AND GYNECOLOGY   68 ( 3 )   243 - 247   2016( ISSN:03708446

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    <p>Retroperitoneal fibrosis is characterized by fibrosis of retroperitoneal cavity and causes the ureteral stricture and obstruction, and hydronephrosis is caused by impaired ureteral peristalsis. We report a case of cervical adenocarcinoma, which was diagnosed after detection of bilateral hydronephrosis caused by retroperitoneal fibrosis. The patient was a 35-year-old non-gravida woman with no past history. She was reffered to another physician, with a compliant of right abdominal pain. Bilateral hydronephrosis and high serum creatinine level (3.8 mg/dl) were detected. She underwent bilateral ureteral stent placement, but renal function did not improve, so she was reffered to the Department of Urology at our hospital. She underwent bilateral nephrostomy and reffered to our Department. No cervical tumor was detected by ultrasonography, but uterine cervix cytology was SCC suspected and colposcopy detected a small tumorous lesion of the cervix. Cervical biopsy was performed and the histology showed mucinous adenocarcinoma. Magnetic resonance imaging revealed no cervical tumor and no lymph node swelling in the pelvis. Computed tomography did not reveal any metastasis. She was diagnosed with cervical cancer stage I B1 and we performed radical hysterectomy and bilateral salpingo-oophorectomy. Intraoperatively, we found marked retroperitoneal fibrosis and harden, inflexible urinary ducts, so retroperitoneal fibrosis was suspected. Macroscopically, there was a mass of 5 mm diameter in the uterine cervix, but no lymph node swelling in the pelvis. Histopathological examination revealed usual-type endocervical adenocarcinoma, with bilateral parametrial invasion, bilateral ovarian metastasis, and retroperitoneal lymph node metastasis, and retroperitoneal infiltrate around bilateral ureters. We considered that this case was cervical adenocarcinoma complicated with bilateral hydronephrosis caused by retroperitoneal fibrosis. She received adjuvant chemotherapy, but she died of the disease 17 months after initial treatment and showed a poor prognosis. This case suggests that we should consider a diagnosis of retroperitoneal fibrosis, when hydronephrosis without obvious organic dysfuncion is detected. [Adv Obstet Gynecol, 68 (3) : 243-247, 2016 (H28.8)]</p>

    DOI: 10.11437/sanpunosinpo.68.243

    CiNii Article

  • 私たちが行う針生検 ; 子宮筋層病変生検研究会からの報告 : その手技から診断まで(子宮筋層・内膜症病変生検研究会,ハンズオンセミナー,公益社団法人日本産科婦人科学会第68回学術講演会) Reviewed

    市村 友季

    日本産科婦人科学会 日本産科婦人科學會雜誌   68 ( 2 )   2016

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  • Chemotherapy-induced neutropenia and febrile neutropenia in patients with gynecologic malignancy Reviewed

    Hashiguchi Yasunori, Kasai Mari, Fukuda Takeshi, Ichimura Tomoyuki, Yasui Tomoyo, Sumi Toshiyuki

    ANTI-CANCER DRUGS   26 ( 10 )   1054 - 1060   2015.11( ISSN:0959-4973

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    DOI: 10.1097/CAD.0000000000000279

    PubMed

  • Chemotherapy-induced neutropenia and febrile neutropenia in patients with gynecologic malignancy Reviewed

    Yasunori Hashiguchi, Mari Kasai, Takeshi Fukuda, Tomoyuki Ichimura, Tomoyo Yasui, Toshiyuki Sumi

    ANTI-CANCER DRUGS   26 ( 10 )   1054 - 60   2015.11( ISSN:0959-4973

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    Chemotherapy-induced neutropenia is a common complication in cancer treatment. In this study, we investigated chemotherapy-induced neutropenia that was recently detected in all patients with gynecologic malignancy. Between January 2009 and December 2011, we examined cases of chemotherapy-induced neutropenia reported in our hospital. We analyzed the incidence and clinical features of chemotherapy-induced neutropenia and febrile neutropenia in patients with gynecologic malignancy. During the study period, we administered over 1614 infusions (29 regimens) to 291 patients. The median age of the patients was 60 years (range 24-84 years). Chemotherapy-induced neutropenia occurred in 147 (50.5%) patients over 378 (23.4%) chemotherapy cycles. Febrile neutropenia occurred in 20 (6.9%) patients over 25 (1.5%) cycles. The mean duration of neutropenia and fever was 3.6 days (range 1-12 days) and 3.4 days (range 1-9 days), respectively. The source of fever was unexplained by examination or cultures in 14 (56.0%) cycles. There were two cases of neutropenia-related death. Chemotherapy-induced neutropenia was associated with older age (over 70 years) (P &lt; 0.0001), less than five previous chemotherapy cycles (P = 0.02), disseminated disease (P = 0.03), platinum-based regimens (P &lt; 0.0001), taxane-containing regimens (P &lt; 0.0001), and combined therapy (P &lt; 0.0001). Febrile neutropenia was associated with poor performance status (P &lt; 0.0001), no previous chemotherapy (P &lt; 0.05), disseminated disease (P &lt; 0.0001), and distant metastatic disease (P = 0.03). Neither chemotherapy-induced neutropenia nor febrile neutropenia was associated with bone marrow metastases or previous radiotherapy. By identifying risk factors for febrile neutropenia, such as performance status, no previous chemotherapy, disseminated disease, and distant metastatic disease, the safe management of chemotherapy-induced neutropenia may be possible in patients with gynecologic malignancy. Copyright (C) 2015 Wolters Kluwer Health, Inc. All rights reserved.

    DOI: 10.1097/CAD.0000000000000279

    PubMed

  • CLINICAL ANALYSIS OF SIX PATIENTS WITH PRIMARY MALIGNANT MELANOMA IN VULVA AND VAGINA Reviewed

    Tasaka M., Fukuda T., Wada T., Kawanishi M., Imai K., Yamauchi M., Kasai M., Hashiguchi Y., Ichimura T., Yasui T., Deguchi M., Sumi T.

    INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER   25 ( 9 )   1676 - 1676   2015.10( ISSN:1048-891X

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  • 針生検で診断された子宮悪性リンパ腫の2症例(Two cases of uterine malignant lymphoma diagnosed by needle biopsy) Reviewed

    Kasai Mari, Ichimura Tomoyuki, Murakami Makoto, Matsuda Makiko, Kawamura Naoki, Sumi Toshiyuki

    John Wiley & Sons Australia, Ltd The Journal of Obstetrics and Gynaecology Research   41 ( 10 )   1664 - 1668   2015.10( ISSN:1341-8076

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    症例1:下腹部痛を主訴として子宮腫脹と右側水腎症と診断された67歳女性(妊娠4回、出産3回)症例について検討した。腫瘍とリンパ節(LN)腫脹を示すMRI所見とsoluble interleukin-2 receptor(s-IL2R)の著明な高値から、子宮体部の悪性リンパ腫(ML)が疑われた。経頸管的針生検で採取した腫瘍組織標本の免疫組織化学染色によりびまん性大細胞型B細胞性リンパ腫(DLBCL)第4期と診断し、CTでは骨盤および傍大動脈LN転移を認めた。6サイクルR-CHOP療法施行後3年10ヵ月間のフォローアップ中の再発はなかった。症例2:下腹部痛を主訴として子宮腫脹と右側水腎症と診断された77歳女性(妊娠3回、出産2回)症例について検討した。腫瘤とLN腫脹を示すMRI所見と血清lactate dehydrogenaseの著明な高値から、筋層内の腫瘍増殖が疑われた。経頸管的針生検で採取した標本の免疫組織化学検査によりDLBCL第4期と診断し、PETでは肝臓、腸間膜、左鼠径LNにhot lesionを認めた。6サイクルのR-CHOP療法施行後9ヵ月間のフォローアップ中の再発はなかった。

  • Two cases of uterine malignant lymphoma diagnosed by needle biopsy Reviewed

    Kasai Mari, Ichimura Tomoyuki, Murakami Makoto, Matsuda Makiko, Kawamura Naoki, Sumi Toshiyuki

    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH   41 ( 10 )   1664 - 1668   2015.10( ISSN:1341-8076

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    DOI: 10.1111/jog.12759

    PubMed

  • SAFETY AND EFFICACY OF DOCETAXEL PLUS CISPLATIN FOR THE PATIENTS WITH ENDOMETRIAL CANCER Reviewed

    Fukuda T., Wada T., Kawanishi M., Imai K., Tasaka R., Yamauchi M., Kasai M., Hashiguchi Y., Ichimura T., Yasui T., Deguchi M., Sumi T.

    INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER   25 ( 9 )   1060 - 1060   2015.10( ISSN:1048-891X

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  • PEGYLATED LIPOSOMAL DOXORUBICIN FOR PLATINUM-RESISTANT OR REFRACTORY MULLERIAN CARCINOMA (EPITHELIAL OVARIAN CARCINOMA, PRIMARY CARCINOMA OF FALLOPIAN TUBE AND PERITONEAL CARCINOMA) Reviewed

    Wada T., Fukuda T., Kawanishi M., Imai K., Tasaka R., Yamauchi M., Kasai M., Hashiguchi Y., Ichimura T., Deguchi M., Yasui T., Sumi T.

    INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER   25 ( 9 )   429 - 429   2015.10( ISSN:1048-891X

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  • CLINICAL ANALYSIS OF SIX PATIENTS WITH PRIMARY MALIGNANT MELANOMA IN VULVA AND VAGINA Reviewed

    M. Tasaka, T. Fukuda, T. Wada, M. Kawanishi, K. Imai, M. Yamauchi, M. Kasai, Y. Hashiguchi, T. Ichimura, T. Yasui, M. Deguchi, T. Sumi

    INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER   25 ( 9 )   1676 - 1676   2015.10( ISSN:1048-891X

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  • Two cases of uterine malignant lymphoma diagnosed by needle biopsy Reviewed

    Mari Kasai, Tomoyuki Ichimura, Makoto Murakami, Makiko Matsuda, Naoki Kawamura, Toshiyuki Sumi

    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH   41 ( 10 )   1664 - 8   2015.10( ISSN:1341-8076

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    The incidence of primary malignant lymphoma arising in the female genital tract is extremely rare and constitutes approximately 0.05% of malignant tumors. Uterine malignant lymphoma develops in the endometrial stroma, causing minimal necrosis. It is therefore difficult to diagnose malignant lymphoma, as it does not involve genital bleeding or epithelial defects. We have performed transcervical needle biopsies from deep in the myometrium, with the purpose of diagnosing uterine muscle layer lesions, such as leiomyosarcoma, but this is an unusual method. In this report, we suggest that transcervical needle biopsy is useful in the diagnosis of uterine malignant lymphoma.

    DOI: 10.1111/jog.12759

    PubMed

  • SAFETY AND EFFICACY OF DOCETAXEL PLUS CISPLATIN FOR THE PATIENTS WITH ENDOMETRIAL CANCER Reviewed

    T. Fukuda, T. Wada, M. Kawanishi, K. Imai, R. Tasaka, M. Yamauchi, M. Kasai, Y. Hashiguchi, T. Ichimura, T. Yasui, M. Deguchi, T. Sumi

    INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER   25 ( 9 )   1060 - 1060   2015.10( ISSN:1048-891X

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  • PEGYLATED LIPOSOMAL DOXORUBICIN FOR PLATINUM-RESISTANT OR REFRACTORY MULLERIAN CARCINOMA (EPITHELIAL OVARIAN CARCINOMA, PRIMARY CARCINOMA OF FALLOPIAN TUBE AND PERITONEAL CARCINOMA) Reviewed

    T. Wada, T. Fukuda, M. Kawanishi, K. Imai, R. Tasaka, M. Yamauchi, M. Kasai, Y. Hashiguchi, T. Ichimura, M. Deguchi, T. Yasui, T. Sumi

    INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER   25 ( 9 )   429 - 429   2015.10( ISSN:1048-891X

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  • 針生検で診断された子宮悪性リンパ腫の2症例(Two cases of uterine malignant lymphoma diagnosed by needle biopsy)

    Kasai Mari, Ichimura Tomoyuki, Murakami Makoto, Matsuda Makiko, Kawamura Naoki, Sumi Toshiyuki

    The Journal of Obstetrics and Gynaecology Research   41 ( 10 )   1664 - 1668   2015.10( ISSN:1341-8076

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    症例1:下腹部痛を主訴として子宮腫脹と右側水腎症と診断された67歳女性(妊娠4回、出産3回)症例について検討した。腫瘍とリンパ節(LN)腫脹を示すMRI所見とsoluble interleukin-2 receptor(s-IL2R)の著明な高値から、子宮体部の悪性リンパ腫(ML)が疑われた。経頸管的針生検で採取した腫瘍組織標本の免疫組織化学染色によりびまん性大細胞型B細胞性リンパ腫(DLBCL)第4期と診断し、CTでは骨盤および傍大動脈LN転移を認めた。6サイクルR-CHOP療法施行後3年10ヵ月間のフォローアップ中の再発はなかった。症例2:下腹部痛を主訴として子宮腫脹と右側水腎症と診断された77歳女性(妊娠3回、出産2回)症例について検討した。腫瘤とLN腫脹を示すMRI所見と血清lactate dehydrogenaseの著明な高値から、筋層内の腫瘍増殖が疑われた。経頸管的針生検で採取した標本の免疫組織化学検査によりDLBCL第4期と診断し、PETでは肝臓、腸間膜、左鼠径LNにhot lesionを認めた。6サイクルのR-CHOP療法施行後9ヵ月間のフォローアップ中の再発はなかった。

  • 針生検で診断された子宮悪性リンパ腫の2症例(Two cases of uterine malignant lymphoma diagnosed by needle biopsy) Reviewed

    Kasai Mari, Ichimura Tomoyuki, Murakami Makoto, Matsuda Makiko, Kawamura Naoki, Sumi Toshiyuki

    John Wiley & Sons Australia, Ltd The Journal of Obstetrics and Gynaecology Research   41 ( 10 )   1664 - 1668   2015.10( ISSN:1341-8076

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    Publishing type:Research paper (scientific journal)  

    症例1:下腹部痛を主訴として子宮腫脹と右側水腎症と診断された67歳女性(妊娠4回、出産3回)症例について検討した。腫瘍とリンパ節(LN)腫脹を示すMRI所見とsoluble interleukin-2 receptor(s-IL2R)の著明な高値から、子宮体部の悪性リンパ腫(ML)が疑われた。経頸管的針生検で採取した腫瘍組織標本の免疫組織化学染色によりびまん性大細胞型B細胞性リンパ腫(DLBCL)第4期と診断し、CTでは骨盤および傍大動脈LN転移を認めた。6サイクルR-CHOP療法施行後3年10ヵ月間のフォローアップ中の再発はなかった。症例2:下腹部痛を主訴として子宮腫脹と右側水腎症と診断された77歳女性(妊娠3回、出産2回)症例について検討した。腫瘤とLN腫脹を示すMRI所見と血清lactate dehydrogenaseの著明な高値から、筋層内の腫瘍増殖が疑われた。経頸管的針生検で採取した標本の免疫組織化学検査によりDLBCL第4期と診断し、PETでは肝臓、腸間膜、左鼠径LNにhot lesionを認めた。6サイクルのR-CHOP療法施行後9ヵ月間のフォローアップ中の再発はなかった。

  • Serum CEA as a tumor marker in patients with endometrial cancer Reviewed

    Hashiguchi Y., Kasai M., Fukuda T., Ichimura T., Yasui T., Sumi T.

    EUROPEAN JOURNAL OF CANCER   51   S539 - S539   2015.09( ISSN:0959-8049

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  • Serum CEA as a tumor marker in patients with endometrial cancer Reviewed

    Hashiguchi Y, Kasai M, Fukuda T, Ichimura T, Yasui T, Sumi T

    EUROPEAN JOURNAL OF CANCER   51   S539 - S539   2015.09( ISSN:0959-8049

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  • Expression of CAVEOLIN 1 in uterine mesenchymal tumors: No relationship between malignancy and CAVEOLIN 1 expression Reviewed

    Hayashi Takuma, Ichimura Tomoyuki, Yaegashi Nobuo, Shiozawa Tanri, Konishi Ikuo

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   463 ( 4 )   982 - 987   2015.08( ISSN:0006-291X

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    DOI: 10.1016/j.bbrc.2015.06.046

    PubMed

  • Expression of CAVEOLIN 1 in uterine mesenchymal tumors: No relationship between malignancy and CAVEOLIN 1 expression Reviewed

    Takuma Hayashi, Tomoyuki Ichimura, Nobuo Yaegashi, Tanri Shiozawa, Ikuo Konishi

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   463 ( 4 )   982 - 7   2015.08( ISSN:0006-291X

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    Although most smooth muscle neoplasms detected in the human uterus are benign, uterine leiomyosarcoma (Ut-LMS) is extremely malignant with high rates of recurrence and metastasis. CAVEOLIN I (CAV1) levels in the epithelial cells of some carcinomas have been reported to increase during tumor progression. We herein evaluated the relationship between CAV1 expression and the pathological features of patients diagnosed with uterine mesenchymal tumors at several clinical facilities. No clinical link was observed between CAV1 expression and the malignancy of human uterine mesenchymal tumors. CAV1 expression was decreased in the normal myometrium, whereas it was strongly expressed in uterine mesenchymal tumors. However, the expression of CAV1 was not a potential biomarker to distinguish Ut-LMS from other types of uterine mesenchymal tumors. The perivascular expression of CAV1 was clearly observed in all types of uterine mesenchymal tumors and myometria. Therefore, the results of the present study suggest that CAV1 may not act as a potential biomarker of uterine malignant mesenchymal tumors. (C) 2015 Elsevier Inc. All rights reserved.

    DOI: 10.1016/j.bbrc.2015.06.046

    PubMed

  • Repeated myiasis in a female vulvar squamous cell carcinoma caused by Lucilia sericata and Sarcophaga crassipalpis Reviewed

    Hiraoka Hiroyuki, Ozawa Toshiyuki, Sowa-Osako Junko, Ichimura Tomoyuki, Kimata-Teramoto Isao, Isozumi Rie, Kaneko Akira, Tsuruta Daisuke

    JOURNAL OF DERMATOLOGY   42 ( 8 )   840 - 841   2015.08( ISSN:0385-2407

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    DOI: 10.1111/1346-8138.12911

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  • Repeated myiasis in a female vulvar squamous cell carcinoma caused by Lucilia sericata and Sarcophaga crassipalpis Reviewed

    Hiroyuki Hiraoka, Toshiyuki Ozawa, Junko Sowa-Osako, Tomoyuki Ichimura, Isao Kimata-Teramoto, Rie Isozumi, Akira Kaneko, Daisuke Tsuruta

    JOURNAL OF DERMATOLOGY   42 ( 8 )   840 - 1   2015.08( ISSN:0385-2407

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    DOI: 10.1111/1346-8138.12911

    PubMed

  • Effect on HPV vaccination in Japan resulting from news report of adverse events and suspension of governmental recommendation for HPV vaccination Reviewed

    Morimoto Akiko, Ueda Yutaka, Egawa-Takata Tomomi, Yagi Asami, Terai Yoshito, Ohmichi Masahide, Ichimura Tomoyuki, Sumi Toshiyuki, Murata Hiromi, Kanzaki Hideharu, Nakai Hidekatsu, Mandai Masaki, Yoshino Kiyoshi, Fujita Masami, Kimura Tadashi, Saito Junko, Sobue Tomotaka, Nishikawa Nobumichi, Sekine Masayuki, Enomoto Takayuki, Horikoshi Yorihiko, Takagi Tetsu

    INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY   20 ( 3 )   549 - 555   2015.06( ISSN:1341-9625

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    DOI: 10.1007/s10147-014-0723-1

    PubMed

  • HPVワクチンの有害事象および厚生労働省からの接種勧奨の一時中止勧告の報道によるHPVワクチン接種への影響(Effect on HPV vaccination in Japan resulting from news report of adverse events and suspension of governmental recommendation for HPV vaccination) Reviewed

    Morimoto Akiko, Ueda Yutaka, Egawa-Takata Tomomi, Yagi Asami, Terai Yoshito, Ohmichi Masahide, Ichimura Tomoyuki, Sumi Toshiyuki, Murata Hiromi, Kanzaki Hideharu, Nakai Hidekatsu, Mandai Masaki, Yoshino Kiyoshi, Fujita Masami, Kimura Tadashi, Saito Junko, Sobue Tomotaka, Nishikawa Nobumichi, Sekine Masayuki, Enomoto Takayuki, Horikoshi Yorihiko, Takagi Tetsu

    シュプリンガー・ジャパン(株) International Journal of Clinical Oncology   20 ( 3 )   549 - 555   2015.06( ISSN:1341-9625

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    12〜18歳でHPVワクチンを公費助成で接種した健常女性2777名を対象として、子宮頸癌、癌検診、HPVワクチンに関する知識と受容度に関する質問票を送付し、HPVワクチンに関する一連の報道がワクチン接種に及ぼす影響について検討した。その結果、質問票の回収率は38%で、HPVワクチンの副作用については回答者の80%が認知していた。また、行政による接種勧奨の一時中止勧告に関する認知度は68%で、有害事象の報道後にワクチン接種を開始した回答者のうち60%が有害事象を認知の上でワクチン接種を続行していたが、29%は中止し、11%は報道を知らずにワクチン接種を続行していた。なお、ワクチン接種を中止した主な理由は有害事象の報道であり、それら有害事象に関して医師に相談した回答者は、相談しない回答者に比べ、ワクチン接種の継続率が有意に高かった。

  • Effect on HPV vaccination in Japan resulting from news report of adverse events and suspension of governmental recommendation for HPV vaccination Reviewed

    Akiko Morimoto, Yutaka Ueda, Tomomi Egawa-Takata, Asami Yagi, Yoshito Terai, Masahide Ohmichi, Tomoyuki Ichimura, Toshiyuki Sumi, Hiromi Murata, Hideharu Kanzaki, Hidekatsu Nakai, Masaki Mandai, Kiyoshi Yoshino, Masami Fujita, Tadashi Kimura, Junko Saito, Tomotaka Sobue, Nobumichi Nishikawa, Masayuki Sekine, Takayuki Enomoto, Yorihiko Horikoshi, Tetsu Takagi

    INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY   20 ( 3 )   549 - 555   2015.06( ISSN:1341-9625

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    Administration of the human papillomavirus (HPV) vaccine decreased dramatically in Japan after extensive news of adverse vaccine events and suspension of the governmental recommendation for the vaccine. In this study, we investigated the knowledge and acceptance of vaccinated adolescents concerning cervical cancer, cancer screening and the HPV vaccine. Furthermore, we analyzed whether and by how much the news affected acceptance of the vaccination.
    This study was conducted as a part of Osaka Clinical resEArch of HPV vacciNe (OCEAN) study. A questionnaire was distributed to 2,777 study registrants.
    The response rate was 38 %. The recognition rate of the news of the vaccine's adverse events was 80 %; it was 68 % for awareness of the government's announcement of the suspension of its recommendation for the vaccine. Among those who had a chance to hear or see the negative news during their vaccination period, 46 (60 %) continued vaccination while knowing of the news, 22 (29 %) discontinued vaccination, and 9 (11 %) continued vaccination without an awareness of the news. Reports of the vaccine's adverse events were the main reason for not continuing the vaccination series. Those who consulted doctors after hearing the adverse news were significantly more likely to continue their vaccinations than those who did not.
    Our results should help in understanding the need for a strong promotion of vaccine usage and cancer screening after future retraction of the recommendation suspension. This may apply to other countries with an unsatisfactory rate of HPV vaccination due to fears of adverse vaccine events.

    DOI: 10.1007/s10147-014-0723-1

  • HPVワクチンの有害事象および厚生労働省からの接種勧奨の一時中止勧告の報道によるHPVワクチン接種への影響(Effect on HPV vaccination in Japan resulting from news report of adverse events and suspension of governmental recommendation for HPV vaccination) Reviewed

    Morimoto Akiko, Ueda Yutaka, Egawa-Takata Tomomi, Yagi Asami, Terai Yoshito, Ohmichi Masahide, Ichimura Tomoyuki, Sumi Toshiyuki, Murata Hiromi, Kanzaki Hideharu, Nakai Hidekatsu, Mandai Masaki, Yoshino Kiyoshi, Fujita Masami, Kimura Tadashi, Saito Junko, Sobue Tomotaka, Nishikawa Nobumichi, Sekine Masayuki, Enomoto Takayuki, Horikoshi Yorihiko, Takagi Tetsu

    シュプリンガー・ジャパン(株) International Journal of Clinical Oncology   20 ( 3 )   549 - 555   2015.06( ISSN:1341-9625

     More details

    Publishing type:Research paper (scientific journal)  

    12〜18歳でHPVワクチンを公費助成で接種した健常女性2777名を対象として、子宮頸癌、癌検診、HPVワクチンに関する知識と受容度に関する質問票を送付し、HPVワクチンに関する一連の報道がワクチン接種に及ぼす影響について検討した。その結果、質問票の回収率は38%で、HPVワクチンの副作用については回答者の80%が認知していた。また、行政による接種勧奨の一時中止勧告に関する認知度は68%で、有害事象の報道後にワクチン接種を開始した回答者のうち60%が有害事象を認知の上でワクチン接種を続行していたが、29%は中止し、11%は報道を知らずにワクチン接種を続行していた。なお、ワクチン接種を中止した主な理由は有害事象の報道であり、それら有害事象に関して医師に相談した回答者は、相談しない回答者に比べ、ワクチン接種の継続率が有意に高かった。

  • HPVワクチンの有害事象および厚生労働省からの接種勧奨の一時中止勧告の報道によるHPVワクチン接種への影響(Effect on HPV vaccination in Japan resulting from news report of adverse events and suspension of governmental recommendation for HPV vaccination)

    Morimoto Akiko, Ueda Yutaka, Egawa-Takata Tomomi, Yagi Asami, Terai Yoshito, Ohmichi Masahide, Ichimura Tomoyuki, Sumi Toshiyuki, Murata Hiromi, Kanzaki Hideharu, Nakai Hidekatsu, Mandai Masaki, Yoshino Kiyoshi, Fujita Masami, Kimura Tadashi, Saito Junko, Sobue Tomotaka, Nishikawa Nobumichi, Sekine Masayuki, Enomoto Takayuki, Horikoshi Yorihiko, Takagi Tetsu

    International Journal of Clinical Oncology   20 ( 3 )   549 - 555   2015.06( ISSN:1341-9625

     More details

    12〜18歳でHPVワクチンを公費助成で接種した健常女性2777名を対象として、子宮頸癌、癌検診、HPVワクチンに関する知識と受容度に関する質問票を送付し、HPVワクチンに関する一連の報道がワクチン接種に及ぼす影響について検討した。その結果、質問票の回収率は38%で、HPVワクチンの副作用については回答者の80%が認知していた。また、行政による接種勧奨の一時中止勧告に関する認知度は68%で、有害事象の報道後にワクチン接種を開始した回答者のうち60%が有害事象を認知の上でワクチン接種を続行していたが、29%は中止し、11%は報道を知らずにワクチン接種を続行していた。なお、ワクチン接種を中止した主な理由は有害事象の報道であり、それら有害事象に関して医師に相談した回答者は、相談しない回答者に比べ、ワクチン接種の継続率が有意に高かった。

  • Complete recovery from paraneoplastic anti-NMDAR encephalitis associated with a small ovarian teratoma following a laparoscopic salpingo-oophorectomy: A case report Reviewed

    Imai Kenji, Fukuda Takeshi, Wada Takuma, Kawanishi Masaru, Yamauchi Makoto, Hashiguchi Yasunori, Ichimura Tomoyuki, Yasui Tomoyo, Sumi Toshiyuki

    EXPERIMENTAL AND THERAPEUTIC MEDICINE   9 ( 5 )   1723 - 1726   2015.05( ISSN:1792-0981

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    DOI: 10.3892/etm.2015.2344

    PubMed

  • Complete recovery from paraneoplastic anti-NMDAR encephalitis associated with a small ovarian teratoma following a laparoscopic salpingo-oophorectomy: A case report Reviewed

    Kenji Imai, Takeshi Fukuda, Takuma Wada, Masaru Kawanishi, Makoto Yamauchi, Yasunori Hashiguchi, Tomoyuki Ichimura, Tomoyo Yasui, Toshiyuki Sumi

    EXPERIMENTAL AND THERAPEUTIC MEDICINE   9 ( 5 )   1723 - 1726   2015.05( ISSN:1792-0981

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    Anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis is a severe but treatment-responsive disorder, initially identified in young women with an ovarian teratoma. Symptoms include mood, behavior and personality irregularities that resemble acute psychosis. The present study reports the rare case of a patient with anti-NMDAR encephalitis and severe neurological symptoms, that exhibited a rapid recovery following a laparoscopic salpingo-oophorectomy. The 39-year-old woman was admitted to the Department of Obstetrics and Gynecology, Osaka City University Graduate School of Medicine (Osaka, Japan) with a 5-day history of fever and stomach ache. One week later, the patient developed hallucinations and emotional lability. Initially, a diagnosis of limbic or herpes encephalitis was considered; thus, the patient was administered acyclovir and received steroid pulse therapy. However, the patient subsequently developed apnea, and in response, a tracheal intubation, mechanical ventilation and plasmapheresis were performed. Anti-NMDAR encephalitis was subsequently considered as a diagnosis and mediastinal and pelvic computed tomography (CT) examinations were conducted to detect for the presence of a teratoma. A 24x24-mm cystic lesion was identified in the pelvis from an abdominal CT scan and the lesion appeared to be an ovarian teratoma. In addition, serum and cerebrospinal fluid samples were collected, and were found to test positive for anti-NMDAR antibodies. A laparoscopic salpingo-oophorectomy was performed, which resulted in rapid improvement of the patient's mental symptoms, followed by a complete recovery.

    DOI: 10.3892/etm.2015.2344

    PubMed

  • Primary peritoneal cancer: study of 14 cases and comparison with epithelial ovarian cancer Reviewed

    Fukuda T., Imai K., Yamauchi M., Teramae M., Hashiguchi Y., Ichimura T., Yasui T., Sumi T.

    EUROPEAN JOURNAL OF GYNAECOLOGICAL ONCOLOGY   36 ( 1 )   49 - 53   2015( ISSN:0392-2936

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  • Early operative treatment of anti-N-methyl D-aspartate (anti-NMDA) receptor encephalitis in a patient with ovarian teratoma Reviewed

    Yanai S., Hashiguchi Y., Kasai M., Fukuda T., Ichimura T., Yasui T., Sumi T.

    CLINICAL AND EXPERIMENTAL OBSTETRICS & GYNECOLOGY   42 ( 6 )   819 - 821   2015( ISSN:0390-6663

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  • Chemotherapy-induced thrombocytopenia and clinical bleeding in patients with gynecologic malignancy Reviewed

    Hashiguchi Y., Fukuda T., Ichimura T., Matsumoto Y., Yasui T., Sumi T., Ishiko O.

    EUROPEAN JOURNAL OF GYNAECOLOGICAL ONCOLOGY   36 ( 2 )   168 - 173   2015( ISSN:0392-2936

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  • Primary peritoneal cancer: study of 14 cases and comparison with epithelial ovarian cancer Reviewed

    T. Fukuda, K. Imai, M. Yamauchi, M. Teramae, Y. Hashiguchi, T. Ichimura, T. Yasui, T. Sumi

    EUROPEAN JOURNAL OF GYNAECOLOGICAL ONCOLOGY   36 ( 1 )   49 - 53   2015( ISSN:0392-2936

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    Purpose of investigation: Primary peritoneal carcinoma (PPC) is histologically similar to ovarian serous carcinoma, but its biochemical features remain obscure. The authors investigated and compared clinical findings, treatments, and outcomes of patients with PPS and those with epithelial ovarian cancer (EOC) patients. Materials and Methods: The authors retrospectively reviewed data from 14 patients with PPC and 219 patients with EOC treated at the present hospital from January 2005 to December 2012, including demographic data, pathologic findings, treatments, and outcomes. Results: Patients with PPC were significantly older (62.6 +/- 8.4 years) than those with EOC (56.3 +/- 11.3 years) (p = 0.045). There was no significant difference in serum CA-125 levels. The five-year survival rates did not differ significantly between patients with PPC (61.1%) and those with EOC (60.3%; p = 0.78); nor between patients with PPC and those with Stage III serous EOC (43.8%; p = 0.40). Conclusions: Treatment strategies for EOC applied to PPC apparently led to similar survival patterns among the two patient groups. Cytoreductive surgery combined with pre/postoperative platinum-containing chemotherapy may be effective for PPC patients.

  • Early operative treatment of anti-N-methyl D-aspartate (anti-NMDA) receptor encephalitis in a patient with ovarian teratoma Reviewed

    S. Yanai, Y. Hashiguchi, M. Kasai, T. Fukuda, T. Ichimura, T. Yasui, T. Sumi

    CLINICAL AND EXPERIMENTAL OBSTETRICS & GYNECOLOGY   42 ( 6 )   819 - 821   2015( ISSN:0390-6663

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    Background: Anti-N-methyl D-aspartate (anti-NMDA) receptor encephalitis is often accompanied by ovarian teratoma. Early tumor resection is reported to be effective as a treatment. Case: A 21-year-old woman presented with anti-NMDA receptor encephalitis which was accompanied by ovarian teratoma. The present case was a very rare case of an early stage of anti-NMDA receptor encephalitis receiving operative treatment before confirming the presence of anti-NMDA receptor antibody. The diagnosis was established postoperatively by identifying anti-NMDA receptor antibody. Conclusion: In case of suspecting anti-NMDA receptor encephalitis in a patient with ovarian teratoma, early operative treatment should be considered even before confirming the presence of anti-NMDA receptor antibody.

  • Chemotherapy-induced thrombocytopenia and clinical bleeding in patients with gynecologic malignancy Reviewed

    Y. Hashiguchi, T. Fukuda, T. Ichimura, Y. Matsumoto, T. Yasui, T. Sumi, O. Ishiko

    EUROPEAN JOURNAL OF GYNAECOLOGICAL ONCOLOGY   36 ( 2 )   168 - 173   2015( ISSN:0392-2936

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    Objectives: Chemotherapy-induced thrombocytopenia seems to be a relevant problem and the risk of clinical bleeding in patients with gynecologic malignancy is reported to be higher than other malignancy. In this study, the authors investigated chemotherapy-induced thrombocytopenia recently performed in all patients with gynecologic malignancy. Materials and Methods: Between January 2009 and December 2011, the authors examined reported chemotherapy-induced thrombocytopenia using the Common Terminology Criteria for Adverse Events (CTCAE) v.4.0. They analyzed the incidence and clinical features of chemotherapy-induced thrombocytopenia in patients with gynecologic malignancy. Results: During this period they administered over 1,614 infusions (29 regimens) to 291 patients. Chemotherapy-induced thrombocytopenia occurred in 43 (14.8%) patients over 56(3.5%) chemotherapy cycles. Bleeding occurred in 13 (4.5%) patients over 14 (0.9%) cycles. Platelet transfusions were administered for eight (2.7%) patients over eight (0.5%) cycles. Median platelet count at platelet transfusions was 17,000 /mu l Chemotherapy-induced thrombocytopenia was associated with more than five previous chemotherapy cycles, previous radiotherapy, disseminated disease, distant metastatic disease, poor performance status, and taxane-including regimens. Clinical bleeding was associated with previous radiotherapy, distant metastatic disease, poor performance status, and taxane-including regimens. Conclusions: Estimating bleeding risk factor such as previous radiotherapy, distant metastatic disease, poor performance status, and taxane-including regimens seem to be important for safe management of chemotherapy-induced thrombocytopenia.

  • Minimal deviation mucinous adenocarcinoma of the uterine cervix that proved difficult to differentiate from endometrial cancer: A case report Reviewed

    Nishii Yuko, Fukuda Takeshi, Imai Kenji, Yamauchi Makoto, Hashiguchi Yasunori, Ichimura Tomoyuki, Yasui Tomoyo, Sumi Toshiyuki

    ONCOLOGY LETTERS   8 ( 6 )   2481 - 2484   2014.12( ISSN:1792-1074

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    DOI: 10.3892/ol.2014.2532

    PubMed

  • Minimal deviation mucinous adenocarcinoma of the uterine cervix that proved difficult to differentiate from endometrial cancer: A case report.

    Nishii Y, Fukuda T, Imai K, Yamauchi M, Hashiguchi Y, Ichimura T, Yasui T, Sumi T

    Oncology letters   8 ( 6 )   2481 - 2484   2014.12( ISSN:1792-1074

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  • SAFETY AND EFFICACY OF DOCETAXEL PLUS CARBOPLATIN IN MENOPAUSAL PATIENTS WITH MULLERIAN CARCINOMA. Reviewed

    Imai K., Fukuda T., Kawanishi M., Wada T., Yamauchi M., Kasai M., Hashiguchi Y., Ichimura T., Yasui T., Sumi T.

    INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER   24 ( 9 )   164 - 164   2014.11( ISSN:1048-891X

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  • EXPRESSION OF SIRTUIN 1 PREDICTS THE EFFICACY OF NEOADJUVANT CHEMOTHERAPY FOR LOCALLY ADVANCED UTERINE CERVICAL CANCER Reviewed

    Yamauchi M., Fukuda T., Wada T., Kawanishi M., Imai K., Teramae M., Tasaka R., Kasai M., Hashiguchi Y., Ichimura T., Yasui T., Sumi T.

    INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER   24 ( 9 )   545 - 545   2014.11( ISSN:1048-891X

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  • CLINICAL ANALYSIS OF STAGE I TO II ADENOSQUAMOU CARCINOMA OF UTERINE CERVIX Reviewed

    Kawanishi M., Fukuda T., Wada T., Imai K., Yamauchi M., Kasai M., Hashiguchi Y., Ichimura T., Yasui T., Sumi T.

    INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER   24 ( 9 )   648 - 648   2014.11( ISSN:1048-891X

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  • CLINICAL ANALYSIS OF RECURRENT UTERINE CERVICAL CANCER AFTER SURGERY Reviewed

    Wada T., Fukuda T., Kawanishi M., Imai K., Yamauchi M., Hashiguchi Y., Kasai M., Ichimura T., Yasui T., Sumi T.

    INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER   24 ( 9 )   644 - 645   2014.11( ISSN:1048-891X

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  • CLINICAL ANALYSIS OF RECURRENT UTERINE CERVICAL CANCER AFTER SURGERY Reviewed

    Wada T, Fukuda T, Kawanishi M, Imai K, Yamauchi M, Hashiguchi Y, Kasai M, Ichimura T, Yasui T, Sumi T

    INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER   24 ( 9 )   644 - 645   2014.11( ISSN:1048-891X

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  • SAFETY AND EFFICACY OF DOCETAXEL PLUS CARBOPLATIN IN MENOPAUSAL PATIENTS WITH MULLERIAN CARCINOMA. Reviewed

    Imai K, Fukuda T, Kawanishi M, Wada T, Yamauchi M, Kasai M, Hashiguchi Y, Ichimura T, Yasui T, Sumi T

    INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER   24 ( 9 )   164 - 164   2014.11( ISSN:1048-891X

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  • EXPRESSION OF SIRTUIN 1 PREDICTS THE EFFICACY OF NEOADJUVANT CHEMOTHERAPY FOR LOCALLY ADVANCED UTERINE CERVICAL CANCER Reviewed

    Yamauchi M, Fukuda T, Wada T, Kawanishi M, Imai K, Teramae M, Tasaka R, Kasai M, Hashiguchi Y, Ichimura T, Yasui T, Sumi T

    INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER   24 ( 9 )   545 - 545   2014.11( ISSN:1048-891X

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  • CLINICAL ANALYSIS OF STAGE I TO II ADENOSQUAMOU CARCINOMA OF UTERINE CERVIX Reviewed

    Kawanishi M, Fukuda T, Wada T, Imai K, Yamauchi M, Kasai M, Hashiguchi Y, Ichimura T, Yasui T, Sumi T

    INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER   24 ( 9 )   648 - 648   2014.11( ISSN:1048-891X

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  • CHEMOTHERAPY-INDUCED NEUTROPENIA IN PATIENTS WITH GYNECOLOGIC MALIGNANCY Reviewed

    Hashiguchi Yasunori, Fukuda Takeshi, Ichimura Tomoyuki, Yasui Tomoyo, Sumi Toshiyuki

    ANNALS OF ONCOLOGY   25   2014.10( ISSN:0923-7534

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    DOI: 10.1093/annonc/mdu435.94

  • CHEMOTHERAPY-INDUCED NEUTROPENIA IN PATIENTS WITH GYNECOLOGIC MALIGNANCY Reviewed

    Hashiguchi Yasunori, Fukuda Takeshi, Ichimura Tomoyuki, Yasui Tomoyo, Sumi Toshiyuki

    ANNALS OF ONCOLOGY   25   2014.10( ISSN:0923-7534

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    DOI: 10.1093/annonc/mdu435.94

  • Potential diagnostic biomarkers: Differential expression of LMP2/β1i and cyclin B1 in human uterine leiomyosarcoma Reviewed

    Takuma Hayashi, Akiko Horiuchi, Kenji Sano, Nobuyoshi Hiraoka, Tomoyuki Ichimura, Tamotsu Sudo, Osamu Ishiko, Nobuo Yaegashi, Hiroyuki Aburatani, Ikuo Konishi

    Tumori   100 ( 4 )   e99 - e106   2014.07( ISSN:2038-2529

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    Aims and background. Whilst most uterine smooth muscle neoplasms are benign, uterine leiomyosarcoma (Ut-LMS) is extremely malignant with a high incidence of metastasis and recurrence. Gynecological tumors are often associated with female hormone secretion, but no strong link has been detected between human Ut-LMS and the hormonal environment. In fact, the risk factors for Ut-LMS are poorly understood. In addition, no diagnostic biomarkers for differentiating between leiomyoma, a benign tumor, and malignant Ut-LMS have been found. Interestingly, mice that were homozygously deficient for LMP2/β1i were found to spontaneously develop Ut- LMS and exhibited a Ut-LMS prevalence of '40% by 14 months of age. Thus, analyzing potential risk factors for Ut-LMS (such as LMP2/β1i) might aid the development of diagnostic biomarkers and clinical treatments for the condition.
    Methods and study design. Fifty-seven patients (age range: 32-83 years) who had been diagnosed with uterine mesenchymal tumors were chosen from a pathological archive. Tissue samples from these patients were fixed in 10% buffered formalin, incubated in 4% paraformaldehyde for 8 hours, and embedded in paraffin. Tissue sections were stained with hematoxylin and eosin for standard histological examination or were subjected to further processing for immunohistochemical (IHC) examination. Serial Ut-LMS, bizarre leiomyoma, leiomyoma, and myometrium sections were subjected to IHC staining of β-smooth muscle actin, estrogen receptor, cyclin B1, LMP2/β1i, calponin h1, ki-67, tumor protein p53, and progesterone receptor.
    Results. The Ut-LMS samples were positive for cyclin B1 and negative for LMP2/β1i, while the opposite result was obtained for bizarre leiomyoma, leiomyoma, and myometrium samples.
    Conclusions. The expression pattern of LMP2/β1i and cyclin B1 might be a diagnostic biomarker for human Ut-LMS. Studies of the biological roles of LMP2/β1i and/or cyclin B1 could lead to the elucidation of new targets for therapies against Ut-LMS.

    DOI: 10.1700/1636.17918

    PubMed

  • Comparison of outcomes between squamous cell carcinoma and adenocarcinoma in patients with surgically treated stage I-II cervical cancer. Reviewed

    Yamauchi M, Fukuda T, Wada T, Kawanishi M, Imai K, Hashiguchi Y, Ichimura T, Yasui T, Sumi T

    Molecular and clinical oncology   2 ( 4 )   518 - 524   2014.07( ISSN:2049-9450

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    DOI: 10.3892/mco.2014.295

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  • Primitive neuroectodermal tumor originating in the vulva: A case report Reviewed

    Matsuda Makiko, Ichimura Tomoyuki, Kasai Mari, Murakami Makoto, Hoshi Manabu, Kawamura Naoki, Sumi Toshiyuki

    ONCOLOGY LETTERS   8 ( 1 )   187 - 189   2014.07( ISSN:1792-1074

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    DOI: 10.3892/ol.2014.2073

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  • Potential diagnostic biomarkers: differential expression of LMP2/β1i and cyclin B1 in human uterine leiomyosarcoma. Reviewed

    Hayashi T, Horiuchi A, Sano K, Hiraoka N, Ichimura T, Sudo T, Ishiko O, Yaegashi N, Aburatani H, Konishi I

    Tumori   100 ( 4 )   99e - 106e   2014.07( ISSN:0300-8916

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    DOI: 10.1700/1636.17918

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  • Comparison of outcomes between squamous cell carcinoma and adenocarcinoma in patients with surgically treated stage I-II cervical cancer. Reviewed

    Yamauchi M, Fukuda T, Wada T, Kawanishi M, Imai K, Hashiguchi Y, Ichimura T, Yasui T, Sumi T

    Molecular and clinical oncology   2 ( 4 )   518 - 524   2014.07( ISSN:2049-9450

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    DOI: 10.3892/mco.2014.295

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  • Primitive neuroectodermal tumor originating in the vulva: A case report Reviewed

    Makiko Matsuda, Tomoyuki Ichimura, Mari Kasai, Makoto Murakami, Manabu Hoshi, Naoki Kawamura, Toshiyuki Sumi

    Oncology Letters   8 ( 1 )   187 - 189   2014.07( ISSN:1792-1074

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    Primitive neuroectodermal tumors (PNETs) exhibit chromosomal translocations in common with those of Ewing's sarcoma. They usually originate in bone or soft tissue but rarely arise in the vulva. The current case report presents a case of PNET originating in the vulva in a 60-year-old female, who previously underwent enucleation of a vulvar tumor in another hospital. The pathologist suspected a histopathological diagnosis of PNET, and simple vulvectomy and resection of the inguinal lymph nodes were performed. An ~3 cm mass recurred in the right side of the vulva four years following the initial surgery and the tumor was excised. The tumor comprised small, round-to-oval nuclei and stained positively for MIC-2, synaptophysin, neuron-specific enolase and neurofilament antibodies. To date, the patient remains alive and with no evidence of disease four years following multidisciplinary treatment, despite PNETs usually exhibiting a poor prognosis. This is due to the small tumor size and the absence of distant metastasis.

    DOI: 10.3892/ol.2014.2073

    PubMed

  • Potential diagnostic biomarkers: differential expression of LMP2/beta 1i and cyclin B1 in human uterine leiomyosarcoma Reviewed

    Hayashi Takuma, Horiuchi Akiko, Sano Kenji, Hiraoka Nobuyoshi, Ichimura Tomoyuki, Sudo Tamotsu, Ishiko Osamu, Yaegashi Nobuo, Aburatani Hiroyuki, Konishi Ikuo

    TUMORI J   100 ( 4 )   E99 - E106   2014( ISSN:0300-8916

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    DOI: 10.1177/1636.17918

  • Preoperative diagnosis of usual leiomyoma, atypical leiomyoma, and leiomyosarcoma.

    Matsuda M, Ichimura T, Kasai M, Murakami M, Kawamura N, Hayashi T, Sumi T

    Sarcoma   2014   498682   2014( ISSN:1357-714X

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  • Potential diagnostic biomarkers: differential expression of LMP2/beta 1i and cyclin B1 in human uterine leiomyosarcoma Reviewed

    Hayashi Takuma, Horiuchi Akiko, Sano Kenji, Hiraoka Nobuyoshi, Ichimura Tomoyuki, Sudo Tamotsu, Ishiko Osamu, Yaegashi Nobuo, Aburatani Hiroyuki, Konishi Ikuo

    TUMORI J   100 ( 4 )   E99 - E106   2014( ISSN:0300-8916

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    DOI: 10.1177/1636.17918

  • 腹式単純子宮全摘術が排尿に与える影響に関する検討 Reviewed

    山内 真, 福田 武史, 橋口 裕紀, 松本 佳也, 市村 友季, 安井 智代, 角 俊幸, 古山 将康, 石河 修

    日本女性骨盤底医学会 日本女性骨盤底医学会誌   10 ( 1 )   61 - 64   2013.12( ISSN:2187-5669

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    腹式単純子宮全摘出術後に頻尿や尿意切迫感を訴える患者が存在し活過動膀胱(OAB)と診断されることがある。そこで、腹式単純子宮全摘出術が排尿に与える影響を調査し、術後にOABが出現する頻度を検討する。2011年1月から2012年1月までに当施設で腹式単純子宮全摘術を施行した46例を対象とし、術前、術後3日目、術後7日目にそれぞれ1日の尿量、尿回数、飲水量、尿失禁の回数、尿失禁量を測定し、またOAB症状質問票(OABSS)を用いてOABの有無を診断した。術前、術後3日目、術後7日目のそれぞれの平均一日尿量は1538ml、1280ml、1537ml、平均尿回数は8.4回、7.7回、8.5回、平均飲水量は1338ml、1122ml、1261mlと術後3日目で有意に低値となった。術前、術後3日目、術後7日目のそれぞれのOABSS合計点数の平均は1.5、1.8、1.6で有意差を認めなかったが、41例中2例(4.9%)で術後にOABと診断された。頻度は低いが腹式単純子宮全摘術の合併症としてOABの存在を認識する必要があることが示唆された。(著者抄録)

  • 腹式単純子宮全摘術が排尿に与える影響に関する検討

    山内 真, 福田 武史, 橋口 裕紀, 松本 佳也, 市村 友季, 安井 智代, 角 俊幸, 古山 将康, 石河 修

    日本女性骨盤底医学会誌   10 ( 1 )   61 - 64   2013.12( ISSN:2187-5669

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    腹式単純子宮全摘出術後に頻尿や尿意切迫感を訴える患者が存在し活過動膀胱(OAB)と診断されることがある。そこで、腹式単純子宮全摘出術が排尿に与える影響を調査し、術後にOABが出現する頻度を検討する。2011年1月から2012年1月までに当施設で腹式単純子宮全摘術を施行した46例を対象とし、術前、術後3日目、術後7日目にそれぞれ1日の尿量、尿回数、飲水量、尿失禁の回数、尿失禁量を測定し、またOAB症状質問票(OABSS)を用いてOABの有無を診断した。術前、術後3日目、術後7日目のそれぞれの平均一日尿量は1538ml、1280ml、1537ml、平均尿回数は8.4回、7.7回、8.5回、平均飲水量は1338ml、1122ml、1261mlと術後3日目で有意に低値となった。術前、術後3日目、術後7日目のそれぞれのOABSS合計点数の平均は1.5、1.8、1.6で有意差を認めなかったが、41例中2例(4.9%)で術後にOABと診断された。頻度は低いが腹式単純子宮全摘術の合併症としてOABの存在を認識する必要があることが示唆された。(著者抄録)

  • Imprint cytology of transcervical core needle biopsy specimens of uterine leiomyosarcoma-A case report- Reviewed

    SUMIKURA Tomoko, YASUDI Yuzuru, FUKUSHIMA Hiroko, INOUE Takeshi, KASAI Mari, ICHIMURA Tomoyuki, KAWAMURA Naoki

    The Japanese Society of Clinical Cytology, The Journal of the Japanese Society of Clinical Cytology   52 ( 6 )   573 - 578   2013.11( ISSN:03871193

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    <b><i>Background</i></b> : We perform transcervical needle biopsies for uterine myoma-like tumors. In the case reported herein, we carried out imprint cytology examinations of transcervical needle biopsy specimens, and report its usefulness for differential diagnosis between uterine leiomyoma and leiomyosarcoma.<br><b><i>Case</i></b> : A 59-year-old female patient presented to us with the chief complaint of hematuria, and a diagnostic CT revealed a degenerated uterine myoma. Uterine sarcoma was suspected on MRI and PET-CT. We performed transcervical needle biopsies of the uterine tumor ; the specimens showed atypical spindle cells with a mitotic index of 5, but no evidence of coagulative tumor cell necrosis. Imprint cytology of the biopsy specimens showed many loosely adherent spindle cells, apoptotic cells and mitotic cells on a necrotic background, suggesting the diagnosis of leiomyosarcoma. Surgery was performed, and the final histopathological diagnosis was leiomyosarcoma.<br><b><i>Conclusion</i></b> : Needle biopsy is a useful diagnostic method for differentiation between uterine sarcoma and uterine leiomyoma. Evaluation should be performed in the most highly developed section of the tumor, however, this area is not always included in the small specimens obtained by needle biopsy, resulting in the risk of under-evaluation. The combination of imprint cytology of the needle biopsy specimens, including an evaluation of the number of imprinted tumor cells, may provide useful information for differential diagnosis between these tumors.

    DOI: 10.5795/jjscc.52.573

    CiNii Article

  • PLATELET TRANSFUSION DURING CHEMOTHERAPY-INDUCED THROMBOCYTOPENIA IN PATIENTS WITH GYNECOLOGIC MALIGNANCY Reviewed

    Hashiguchi Y., Fukuda T., Yoshida H., Ichimura T., Matsumoto Y., Yasui T., Sumi T., Ishiko O.

    ANNALS OF ONCOLOGY   24   2013.11( ISSN:0923-7534

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    DOI: 10.1093/annonc/mdt460.91

  • 術中腹水細胞診陽性率に関する検討 Reviewed

    大上 健太, 市村 友季, 角 俊幸, 妹尾 紗織, 長嶋 愛子, 栗原 康, 松田 真希子, 福田 武史, 吉田 裕之, 橋口 裕紀, 松本 佳也, 尾崎 宏治, 安井 智代, 石河 修

    「産婦人科の進歩」編集室 産婦人科の進歩   65 ( 4 )   428 - 430   2013.11( ISSN:0370-8446

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    当科で手術を行った卵巣上皮悪性腫瘍119例を対象に、組織型別の術中腹水細胞診陽性率および予後について検討した。その結果、全進行期における細胞診陽性率は、漿液性腺癌で66.7%、明細胞腺癌で57.6%と高く、類内膜腺癌では29.0%と漿液性腺癌および明細胞腺癌と比べ、有意に低い結果となった。I・II期とIII・IV期に分けて検討した場合、類内膜腺癌では進行例でも陽性率43.8%と低く、漿液性腺癌および明細胞腺癌の陽性率と有意差を認めた。粘液性腺癌では陽性率と進行期との間に強い正の相関関係が示された。細胞診陽性率と予後との検討では、明細胞腺癌において陽性例は有意に予後不良であることが確認された。

  • 経子宮頸管的針生検・捺印細胞診が診断に有用であった子宮平滑筋肉腫の1例 Reviewed

    隅蔵 智子, 保地 讓, 福島 裕子, 井上 健, 笠井 真理, 市村 友季, 川村 直樹

    (公社)日本臨床細胞学会 日本臨床細胞学会雑誌   52 ( 6 )   573 - 578   2013.11( ISSN:0387-1193

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    背景:われわれは、子宮筋腫と子宮平滑筋肉腫の鑑別診断目的に経子宮頸管的針生検を行っている。今回、針生検標本の捺印細胞診が診断に有用であった症例を経験したので、その細胞像を報告する。症例:59歳、女性。血尿を主訴に当院泌尿器科受診。腹部CTにて約10cm大の変性子宮筋腫が疑われ当科紹介となった。MRI、FGD-PETで子宮肉腫を否定できなかったため経子宮頸管的針生検を行った。核異型を伴う紡錘形細胞の増生がみられ、核分裂指数5、凝固壊死は認めなかったが、子宮平滑筋肉腫が強く疑われた。捺印細胞診では、壊死性背景に、核クロマチン増量した紡錘形異型細胞が散在性に多数出現し、核分裂像もみられ、子宮平滑筋肉腫を疑う所見であった。単純子宮全摘出術、両側付属器摘出術を施行し、摘出標本の病理組織より子宮平滑筋肉腫stage Ib期と診断した。結論:針生検は子宮筋層病変の診断に有用な検査法ではあるが、異常の程度の最も強い病変部を採取できるとは限らないため過小評価になりやすい。捺印細胞診を併用するとプレパラートへの「出現細胞数の多寡」という新規情報が加わり、有用な鑑別所見となる可能性が示唆された。(著者抄録)

  • PLATELET TRANSFUSION DURING CHEMOTHERAPY-INDUCED THROMBOCYTOPENIA IN PATIENTS WITH GYNECOLOGIC MALIGNANCY Reviewed

    Y. Hashiguchi, T. Fukuda, H. Yoshida, T. Ichimura, Y. Matsumoto, T. Yasui, T. Sumi, O. Ishiko

    ANNALS OF ONCOLOGY   24   2013.11( ISSN:0923-7534

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    DOI: 10.1093/annonc/mdt460.91

  • 経子宮頸管的針生検・捺印細胞診が診断に有用であった子宮平滑筋肉腫の1例 Reviewed

    隅蔵 智子, 保地 讓, 福島 裕子, 井上 健, 笠井 真理, 市村 友季, 川村 直樹

    (公社)日本臨床細胞学会 日本臨床細胞学会雑誌   52 ( 6 )   573 - 578   2013.11( ISSN:0387-1193

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    背景:われわれは、子宮筋腫と子宮平滑筋肉腫の鑑別診断目的に経子宮頸管的針生検を行っている。今回、針生検標本の捺印細胞診が診断に有用であった症例を経験したので、その細胞像を報告する。症例:59歳、女性。血尿を主訴に当院泌尿器科受診。腹部CTにて約10cm大の変性子宮筋腫が疑われ当科紹介となった。MRI、FGD-PETで子宮肉腫を否定できなかったため経子宮頸管的針生検を行った。核異型を伴う紡錘形細胞の増生がみられ、核分裂指数5、凝固壊死は認めなかったが、子宮平滑筋肉腫が強く疑われた。捺印細胞診では、壊死性背景に、核クロマチン増量した紡錘形異型細胞が散在性に多数出現し、核分裂像もみられ、子宮平滑筋肉腫を疑う所見であった。単純子宮全摘出術、両側付属器摘出術を施行し、摘出標本の病理組織より子宮平滑筋肉腫stage Ib期と診断した。結論:針生検は子宮筋層病変の診断に有用な検査法ではあるが、異常の程度の最も強い病変部を採取できるとは限らないため過小評価になりやすい。捺印細胞診を併用するとプレパラートへの「出現細胞数の多寡」という新規情報が加わり、有用な鑑別所見となる可能性が示唆された。(著者抄録)

  • 術中腹水細胞診陽性率に関する検討

    大上 健太, 市村 友季, 角 俊幸, 妹尾 紗織, 長嶋 愛子, 栗原 康, 松田 真希子, 福田 武史, 吉田 裕之, 橋口 裕紀, 松本 佳也, 尾崎 宏治, 安井 智代, 石河 修

    産婦人科の進歩   65 ( 4 )   428 - 430   2013.11( ISSN:0370-8446

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    当科で手術を行った卵巣上皮悪性腫瘍119例を対象に、組織型別の術中腹水細胞診陽性率および予後について検討した。その結果、全進行期における細胞診陽性率は、漿液性腺癌で66.7%、明細胞腺癌で57.6%と高く、類内膜腺癌では29.0%と漿液性腺癌および明細胞腺癌と比べ、有意に低い結果となった。I・II期とIII・IV期に分けて検討した場合、類内膜腺癌では進行例でも陽性率43.8%と低く、漿液性腺癌および明細胞腺癌の陽性率と有意差を認めた。粘液性腺癌では陽性率と進行期との間に強い正の相関関係が示された。細胞診陽性率と予後との検討では、明細胞腺癌において陽性例は有意に予後不良であることが確認された。

  • 術中腹水細胞診陽性率に関する検討 Reviewed

    大上 健太, 市村 友季, 角 俊幸, 妹尾 紗織, 長嶋 愛子, 栗原 康, 松田 真希子, 福田 武史, 吉田 裕之, 橋口 裕紀, 松本 佳也, 尾崎 宏治, 安井 智代, 石河 修

    「産婦人科の進歩」編集室 産婦人科の進歩   65 ( 4 )   428 - 430   2013.11( ISSN:0370-8446

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    当科で手術を行った卵巣上皮悪性腫瘍119例を対象に、組織型別の術中腹水細胞診陽性率および予後について検討した。その結果、全進行期における細胞診陽性率は、漿液性腺癌で66.7%、明細胞腺癌で57.6%と高く、類内膜腺癌では29.0%と漿液性腺癌および明細胞腺癌と比べ、有意に低い結果となった。I・II期とIII・IV期に分けて検討した場合、類内膜腺癌では進行例でも陽性率43.8%と低く、漿液性腺癌および明細胞腺癌の陽性率と有意差を認めた。粘液性腺癌では陽性率と進行期との間に強い正の相関関係が示された。細胞診陽性率と予後との検討では、明細胞腺癌において陽性例は有意に予後不良であることが確認された。

  • 経子宮頸管的針生検・捺印細胞診が診断に有用であった子宮平滑筋肉腫の1例

    隅蔵 智子, 保地 讓, 福島 裕子, 井上 健, 笠井 真理, 市村 友季, 川村 直樹

    日本臨床細胞学会雑誌   52 ( 6 )   573 - 578   2013.11( ISSN:0387-1193

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    背景:われわれは、子宮筋腫と子宮平滑筋肉腫の鑑別診断目的に経子宮頸管的針生検を行っている。今回、針生検標本の捺印細胞診が診断に有用であった症例を経験したので、その細胞像を報告する。症例:59歳、女性。血尿を主訴に当院泌尿器科受診。腹部CTにて約10cm大の変性子宮筋腫が疑われ当科紹介となった。MRI、FGD-PETで子宮肉腫を否定できなかったため経子宮頸管的針生検を行った。核異型を伴う紡錘形細胞の増生がみられ、核分裂指数5、凝固壊死は認めなかったが、子宮平滑筋肉腫が強く疑われた。捺印細胞診では、壊死性背景に、核クロマチン増量した紡錘形異型細胞が散在性に多数出現し、核分裂像もみられ、子宮平滑筋肉腫を疑う所見であった。単純子宮全摘出術、両側付属器摘出術を施行し、摘出標本の病理組織より子宮平滑筋肉腫stage Ib期と診断した。結論:針生検は子宮筋層病変の診断に有用な検査法ではあるが、異常の程度の最も強い病変部を採取できるとは限らないため過小評価になりやすい。捺印細胞診を併用するとプレパラートへの「出現細胞数の多寡」という新規情報が加わり、有用な鑑別所見となる可能性が示唆された。(著者抄録)

  • Chemotherapy-induced neutropenia and febrile neutropenia during chemotherapy for gynaecologic malignancy Reviewed

    Hashiguchi Y., Fukuda T., Ichimura T., Matsumoto Y., Yasui T., Sumi T.

    EUROPEAN JOURNAL OF CANCER   49   S277 - S277   2013.09( ISSN:0959-8049

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  • Chemotherapy-induced neutropenia and febrile neutropenia during chemotherapy for gynaecologic malignancy Reviewed

    Hashiguchi Y, Fukuda T, Ichimura T, Matsumoto Y, Yasui T, Sumi T

    EUROPEAN JOURNAL OF CANCER   49   S277 - S277   2013.09( ISSN:0959-8049

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  • 閉経後早期の子宮筋腫縮小率について Reviewed

    笠井 真理, 市村 友季, 松田 真希子, 村上 誠, 角 俊幸, 石河 修

    金原出版(株) 産婦人科の実際   62 ( 2 )   229 - 234   2013.02( ISSN:0558-4728

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    Publishing type:Research paper (scientific journal)  

    閉経後早期における子宮筋腫収縮率の予測因子について検討した。対象は閉経前に針生検を行った閉経後2年の子宮筋腫25例であり、針生検標本に対してestrogen receptor(ER)とvascular endothelial growth factor(VEGF)の免疫組織化学染色を行うとともに、超音波検査所見、MRI画像所見から子宮筋腫の収縮率を算出し、収縮率とER labeling index(LI)、VEGFスコア(染色強度と染色範囲の積)との関係を評価した。その結果、収縮率はVEGFスコア、ER LIと正の相関を示したが、VEGFスコアとの相関がより強かった。閉経後早期の筋腫縮小に関してはVEGFを介した血流の影響が大きい可能性が示唆され、VEGFを用いた免疫組織学的評価は閉経後の筋腫を取り扱う際の有用な情報となりうると考えられた。

  • 閉経後早期の子宮筋腫縮小率について

    笠井 真理, 市村 友季, 松田 真希子, 村上 誠, 角 俊幸, 石河 修

    産婦人科の実際   62 ( 2 )   229 - 234   2013.02( ISSN:0558-4728

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    閉経後早期における子宮筋腫収縮率の予測因子について検討した。対象は閉経前に針生検を行った閉経後2年の子宮筋腫25例であり、針生検標本に対してestrogen receptor(ER)とvascular endothelial growth factor(VEGF)の免疫組織化学染色を行うとともに、超音波検査所見、MRI画像所見から子宮筋腫の収縮率を算出し、収縮率とER labeling index(LI)、VEGFスコア(染色強度と染色範囲の積)との関係を評価した。その結果、収縮率はVEGFスコア、ER LIと正の相関を示したが、VEGFスコアとの相関がより強かった。閉経後早期の筋腫縮小に関してはVEGFを介した血流の影響が大きい可能性が示唆され、VEGFを用いた免疫組織学的評価は閉経後の筋腫を取り扱う際の有用な情報となりうると考えられた。

  • A study on positive rate of peritoneal fluid cytology Reviewed

    OUE Kenta, HASHIGUCHI Yasunori, MATSUMOTO Yoshinari, OZAKI Kohji, YASUI Tomoyo, ISHIKO Osamu, ICHIMURA Tomoyuki, SUMI Toshiyuki, SEO Saori, NAGASHIMA Aiko, KURIHARA Yasushi, MATSUDA Makiko, FUKUDA Takeshi, YOSHIDA Hiroyuki

    THE OBSTETRICAL GYNECOLOGICAL SOCIETY OF KINKI DISTRICT JAPAN, ADVANCES IN OBSTETRICS AND GYNECOLOGY   65 ( 4 )   428 - 430   2013( ISSN:0370-8446

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    DOI: 10.11437/sanpunosinpo.65.428

    CiNii Article

  • Imprint cytology of transcervical core needle biopsy specimens of uterine leiomyosarcoma—A case report—

    SUMIKURA Tomoko, YASUDI Yuzuru, FUKUSHIMA Hiroko, INOUE Takeshi, KASAI Mari, ICHIMURA Tomoyuki, KAWAMURA Naoki

    The Journal of the Japanese Society of Clinical Cytology   52 ( 6 )   573 - 578   2013( ISSN:03871193

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    <b><i>Background</i></b> : We perform transcervical needle biopsies for uterine myoma-like tumors. In the case reported herein, we carried out imprint cytology examinations of transcervical needle biopsy specimens, and report its usefulness for differential diagnosis between uterine leiomyoma and leiomyosarcoma.<br><b><i>Case</i></b> : A 59-year-old female patient presented to us with the chief complaint of hematuria, and a diagnostic CT revealed a degenerated uterine myoma. Uterine sarcoma was suspected on MRI and PET-CT. We performed transcervical needle biopsies of the uterine tumor ; the specimens showed atypical spindle cells with a mitotic index of 5, but no evidence of coagulative tumor cell necrosis. Imprint cytology of the biopsy specimens showed many loosely adherent spindle cells, apoptotic cells and mitotic cells on a necrotic background, suggesting the diagnosis of leiomyosarcoma. Surgery was performed, and the final histopathological diagnosis was leiomyosarcoma.<br><b><i>Conclusion</i></b> : Needle biopsy is a useful diagnostic method for differentiation between uterine sarcoma and uterine leiomyoma. Evaluation should be performed in the most highly developed section of the tumor, however, this area is not always included in the small specimens obtained by needle biopsy, resulting in the risk of under-evaluation. The combination of imprint cytology of the needle biopsy specimens, including an evaluation of the number of imprinted tumor cells, may provide useful information for differential diagnosis between these tumors.

    DOI: 10.5795/jjscc.52.573

    CiNii Article

  • A study on positive rate of peritoneal fluid cytology Reviewed

    OUE Kenta, ICHIMURA Tomoyuki, SUMI Toshiyuki, SEO Saori, NAGASHIMA Aiko, KURIHARA Yasushi, MATSUDA Makiko, FUKUDA Takeshi, YOSHIDA Hiroyuki, HASHIGUCHI Yasunori, MATSUMOTO Yoshinari, OZAKI Kohji, YASUI Tomoyo, ISHIKO Osamu

    ADVANCES IN OBSTETRICS AND GYNECOLOGY   65 ( 4 )   428 - 430   2013( ISSN:03708446

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    DOI: 10.11437/sanpunosinpo.65.428

    CiNii Article

  • LATE RECURRENCE OF MALIGNANT MELANOMA MIMICKING PRIMARY PERITONEAL CANCER Reviewed

    Hashiguchi Y., Kitamura M., Fukuda T., Yoshida H., Ichimura T., Matsumoto Y., Yasui T., Sumi T., Ishiko O.

    ANNALS OF ONCOLOGY   23   153 - 153   2012.10( ISSN:0923-7534

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  • LATE RECURRENCE OF MALIGNANT MELANOMA MIMICKING PRIMARY PERITONEAL CANCER Reviewed

    Hashiguchi Y, Kitamura M, Fukuda T, Yoshida H, Ichimura T, Matsumoto Y, Yasui T, Sumi T, Ishiko O

    ANNALS OF ONCOLOGY   23   153 - 153   2012.10( ISSN:0923-7534

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  • 子宮頸癌の診断で治療を行った子宮体部腺扁平上皮癌の1例 Reviewed

    井上 裕, 市村 友季, 長嶋 愛子, 和田 夏子, 森下 真成, 笠井 真理, 福田 武史, 吉田 裕之, 橋口 裕紀, 松本 佳也, 安井 智代, 角 俊幸, 石河 修

    「産婦人科の進歩」編集室 産婦人科の進歩   64 ( 3 )   349 - 351   2012.09( ISSN:0370-8446

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    子宮頸部と体部に腫瘍が存在し、原発部位が頸部か体部かの判断が困難な場合、腫瘍が扁平上皮癌であれば頸癌、腺癌なら体癌と診断することが多い。今回著者等は、頸部と体部に腫瘍を認め、頸部腫瘍生検の結果が扁平上皮癌であったため頸癌の診断で手術を行ったところ、摘出標本検査の結果は体部腺扁平上皮癌であった症例を経験した。本例からの教訓として、頸部生検の結果が扁平上皮癌であっても、体部の生検を行う必要があったと考えられた。

  • 子宮頸癌の診断で治療を行った子宮体部腺扁平上皮癌の1例

    井上 裕, 市村 友季, 長嶋 愛子, 和田 夏子, 森下 真成, 笠井 真理, 福田 武史, 吉田 裕之, 橋口 裕紀, 松本 佳也, 安井 智代, 角 俊幸, 石河 修

    産婦人科の進歩   64 ( 3 )   349 - 351   2012.09( ISSN:0370-8446

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    子宮頸部と体部に腫瘍が存在し、原発部位が頸部か体部かの判断が困難な場合、腫瘍が扁平上皮癌であれば頸癌、腺癌なら体癌と診断することが多い。今回著者等は、頸部と体部に腫瘍を認め、頸部腫瘍生検の結果が扁平上皮癌であったため頸癌の診断で手術を行ったところ、摘出標本検査の結果は体部腺扁平上皮癌であった症例を経験した。本例からの教訓として、頸部生検の結果が扁平上皮癌であっても、体部の生検を行う必要があったと考えられた。

  • Prediction of the shrinking rate of uterine leiomyoma nodules using needle biopsy specimens Reviewed

    Kasai Mari, Ichimura Tomoyuki, Kawamura Naoki, Sumikura Tomoko, Matsuda Makiko, Asano Chika, Sumi Toshiyuki, Ishiko Osamu

    FERTILITY AND STERILITY   98 ( 2 )   440 - 443   2012.08( ISSN:0015-0282

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    DOI: 10.1016/j.fertnstert.2012.05.013

    PubMed

  • Prediction of the shrinking rate of uterine leiomyoma nodules using needle biopsy specimens Reviewed

    Mari Kasai, Tomoyuki Ichimura, Naoki Kawamura, Tomoko Sumikura, Makiko Matsuda, Chika Asano, Toshiyuki Sumi, Osamu Ishiko

    Fertility and Sterility   98 ( 2 )   440 - 3   2012.08( ISSN:0015-0282

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    Objective: To determine correlations between shrinkage of uterine leiomyomas after treatment with GnRH agonists (GnRH-a) or menopause and expression levels of estrogen receptors (ER), progesterone receptors (PR), and vascular endothelial growth factor (VEGF). Design: Cohort study. Setting: University teaching hospital. Patient(s): A total of 26 women with uterine leiomyoma. Intervention(s): Ten women were treated with buserelin acetate injection (1.8 mg), four courses every 4 weeks, and 16 women went into menopause naturally. Main Outcome Measure(s): Tumor shrinkage rates determined from magnetic resonance images taken before and after GnRH-a therapy and before and after natural menopause
    immunohistochemical analysis of ER, PR, and VEGF in uterine leiomyoma biopsy specimens taken before intervention or within 6 months before menopause. Result(s): Shrinkage rates of uterine leiomyomas were positively correlated with expression levels of ER in women treated with GnRH-a and in postmenopausal women managed conservatively, and with VEGF expression in women treated with GnRH-a. There were no significant correlations with PR expression levels in either group. Conclusion(s): Estrogen plays the predominant role in myoma shrinkage for women with GnRH-a therapy and naturally menopausal women. Copyright © 2012 American Society for Reproductive Medicine, Published by Elsevier Inc.

    DOI: 10.1016/j.fertnstert.2012.05.013

    PubMed

  • Potential role of LMP2 as an anti-oncogenic factor in human uterine leiomyosarcoma: Morphological significance of calponin h1 Reviewed

    Hayashi Takuma, Horiuchi Akiko, Sano Kenji, Hiraoka Nobuyoshi, Kasai Mari, Ichimura Tomoyuki, Sudo Tamotsu, Nishimura Ryuichiro, Ishiko Osamu, Shiozawa Tanri, Kanai Yae, Yaegashi Nobuo, Aburatani Hiroyuki, Konishi Ikuo

    FEBS LETTERS   586 ( 13 )   1824 - 1831   2012.06( ISSN:1873-3468

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    DOI: 10.1016/j.febslet.2012.05.029

    PubMed

  • Potential role of LMP2 as an anti-oncogenic factor in human uterine leiomyosarcoma: Morphological significance of calponin h1 Reviewed

    Takuma Hayashi, Akiko Horiuchi, Kenji Sano, Nobuyoshi Hiraoka, Mari Kasai, Tomoyuki Ichimura, Tamotsu Sudo, Ryuichiro Nishimura, Osamu Ishiko, Tanri Shiozawa, Yae Kanai, Nobuo Yaegashi, Hiroyuki Aburatani, Ikuo Konishi

    FEBS Letters   586 ( 13 )   1824 - 1831   2012.06( ISSN:0014-5793

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    Uterine leiomyosarcoma (LMS) is a highly metastatic smooth muscle neoplasm for which calponin h1 is suspected to have a biological role as a tumor-suppressor. We earlier reported that LMP2-null mice spontaneously develop uterine LMS through malignant transformation of the myometrium, thus implicating this protein as an anti-tumorigenic candidate as well. In the present study, we show that LMP2 may negatively regulate LMS independently of its role in the proteasome. Moreover, several lines of evidence indicate that although calponin h1 does not directly influence tumorigenesis, it clearly affects LMP2-induced cellular morphological changes. Modulation of LMP2 may lead to new therapeutic approaches in human uterine LMS. © 2012 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

    DOI: 10.1016/j.febslet.2012.05.029

    PubMed

  • 抗癌剤耐性 卵巣癌におけるtight junction構成蛋白質とcisplatin感受性に関する検討 Reviewed

    吉田 裕之, 角 俊幸, 寺前 雅大, 森下 真成, 中野 雄介, 笠井 真理, 福田 武史, 橋口 裕紀, 市村 友季, 松本 佳也, 安井 智代, 石河 修

    (公社)日本婦人科腫瘍学会 日本婦人科腫瘍学会雑誌   30 ( 1 )   35 - 39   2012.01( ISSN:1347-8559

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    Claudin-4は細胞間接着装置であるtight junctionの主要な構成分子であり、卵巣癌の発癌・進展に重要な役割を担っていると報告されているが、抗癌剤耐性機序への関与については不明である。そこで今回claudin-4と卵巣癌のcisplatin耐性との関連について検討した。卵巣癌細胞株のclaudin-4発現をsiRNAにて抑制し、cisplatinへの感受性変化を検討した。さらにclaudin-4発現とcisplatinの細胞内蓄積量の相関についても検討した。またinformed consentを得た卵巣癌症例の手術切除標本を用いて、claudin-4発現とプラチナ製剤を中心とした化学療法の効果および患者予後との関連を免疫組織学的に検討した。Claudin-4発現抑制により、卵巣癌細胞株のcisplatin感受性が増大し、またcisplatinの細胞内蓄積量の増加がみられた。一方、卵巣癌臨床検体におけるclaudin-4発現を化学療法奏効例と無効例において比較したところ、無効例で有意にその発現が増大していた。またclaudin-4発現陽性症例は陰性症例と比較して有意に予後不良であった。以上よりclaudin-4は卵巣癌のcisplatin耐性機序に関与しており、また予後因子となる可能性が示唆された。(著者抄録)

  • 抗癌剤耐性 卵巣癌におけるtight junction構成蛋白質とcisplatin感受性に関する検討 Reviewed

    吉田 裕之, 角 俊幸, 寺前 雅大, 森下 真成, 中野 雄介, 笠井 真理, 福田 武史, 橋口 裕紀, 市村 友季, 松本 佳也, 安井 智代, 石河 修

    (公社)日本婦人科腫瘍学会 日本婦人科腫瘍学会雑誌   30 ( 1 )   35 - 39   2012.01( ISSN:1347-8559

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    Publishing type:Research paper (scientific journal)  

    Claudin-4は細胞間接着装置であるtight junctionの主要な構成分子であり、卵巣癌の発癌・進展に重要な役割を担っていると報告されているが、抗癌剤耐性機序への関与については不明である。そこで今回claudin-4と卵巣癌のcisplatin耐性との関連について検討した。卵巣癌細胞株のclaudin-4発現をsiRNAにて抑制し、cisplatinへの感受性変化を検討した。さらにclaudin-4発現とcisplatinの細胞内蓄積量の相関についても検討した。またinformed consentを得た卵巣癌症例の手術切除標本を用いて、claudin-4発現とプラチナ製剤を中心とした化学療法の効果および患者予後との関連を免疫組織学的に検討した。Claudin-4発現抑制により、卵巣癌細胞株のcisplatin感受性が増大し、またcisplatinの細胞内蓄積量の増加がみられた。一方、卵巣癌臨床検体におけるclaudin-4発現を化学療法奏効例と無効例において比較したところ、無効例で有意にその発現が増大していた。またclaudin-4発現陽性症例は陰性症例と比較して有意に予後不良であった。以上よりclaudin-4は卵巣癌のcisplatin耐性機序に関与しており、また予後因子となる可能性が示唆された。(著者抄録)

  • 抗癌剤耐性 卵巣癌におけるtight junction構成蛋白質とcisplatin感受性に関する検討

    吉田 裕之, 角 俊幸, 寺前 雅大, 森下 真成, 中野 雄介, 笠井 真理, 福田 武史, 橋口 裕紀, 市村 友季, 松本 佳也, 安井 智代, 石河 修

    日本婦人科腫瘍学会雑誌   30 ( 1 )   35 - 39   2012.01( ISSN:1347-8559

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    Claudin-4は細胞間接着装置であるtight junctionの主要な構成分子であり、卵巣癌の発癌・進展に重要な役割を担っていると報告されているが、抗癌剤耐性機序への関与については不明である。そこで今回claudin-4と卵巣癌のcisplatin耐性との関連について検討した。卵巣癌細胞株のclaudin-4発現をsiRNAにて抑制し、cisplatinへの感受性変化を検討した。さらにclaudin-4発現とcisplatinの細胞内蓄積量の相関についても検討した。またinformed consentを得た卵巣癌症例の手術切除標本を用いて、claudin-4発現とプラチナ製剤を中心とした化学療法の効果および患者予後との関連を免疫組織学的に検討した。Claudin-4発現抑制により、卵巣癌細胞株のcisplatin感受性が増大し、またcisplatinの細胞内蓄積量の増加がみられた。一方、卵巣癌臨床検体におけるclaudin-4発現を化学療法奏効例と無効例において比較したところ、無効例で有意にその発現が増大していた。またclaudin-4発現陽性症例は陰性症例と比較して有意に予後不良であった。以上よりclaudin-4は卵巣癌のcisplatin耐性機序に関与しており、また予後因子となる可能性が示唆された。(著者抄録)

  • A case of corpus adenosquamous carcinoma treated for cervical carcinoma Reviewed

    INOUE Yutaka, MATSUMOTO Yoshinari, YASUI Tomoyo, SUMI Toshiyuki, ISHIKO Osamu, ICHIMURA Tomoyuki, NAGASHIMA Aiko, WADA Natsuko, MORISHITA Masanari, KASAI Mari, FUKUDA Takeshi, YOSHIDA Hiroyuki, HASHIGUCHI Yasunori

    THE OBSTETRICAL GYNECOLOGICAL SOCIETY OF KINKI DISTRICT JAPAN, ADVANCES IN OBSTETRICS AND GYNECOLOGY   64 ( 3 )   349 - 351   2012( ISSN:0370-8446

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    DOI: 10.11437/sanpunosinpo.64.349

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  • Chemotherapy-related hypersensitivity reaction in Japanese patients with gynecologic malignancy Reviewed

    Kitada K., Hashiguchi Y., Fukuda T., Yoshida H., Ichimura T., Matsumoto Y., Yasui T., Sumi T., Ishiko O.

    EUROPEAN JOURNAL OF GYNAECOLOGICAL ONCOLOGY   33 ( 3 )   252 - 254   2012( ISSN:0392-2936

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  • Chemotherapy-related hypersensitivity reaction in Japanese patients with gynecologic malignancy.

    Kitada K, Hashiguchi Y, Fukuda T, Yoshida H, Ichimura T, Matsumoto Y, Yasui T, Sumi T, Ishiko O

    European journal of gynaecological oncology   33 ( 3 )   252 - 4   2012( ISSN:0392-2936

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  • Chemotherapy-related hypersensitivity reaction in Japanese patients with gynecologic malignancy Reviewed

    K. Kitada, Y. Hashiguchi, T. Fukuda, H. Yoshida, T. Ichimura, Y. Matsumoto, T. Yasui, T. Sumi, O. Ishiko

    European Journal of Gynaecological Oncology   33 ( 3 )   252 - 254   2012( ISSN:0392-2936

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    Purpose of investigation: Chemotherapy-related hypersensitivity reaction seems to be problematic in the safe management of chemotherapy. In this study we investigated chemotherapy-related hypersensitivity reaction in patients with gynecologic malignancy. Methods: Between January 2009 and December 2010, we examined hypersensitivity reaction (≥ grade2) using the Common Terminology Criteria for Adverse Events (CTCAE) v.4.0. We analyzed the incidence, clinical features, management, and outcome. Results: We administered over 1,057 infusions (24 regimens) to 205 patients. We found a total of four hypersensitivity reactions (≥ grade 2) cases (carboplatin: 2
    nedaplatin: 1
    docetaxel: 1). Signs and symptoms were varied. In two cases, the same regimen was rechallenged by using anti-allergic drugs. The docetaxel case was successful. The carboplatin case was not successful. Conclusion: Chemotherapy-related hypersensitivity reaction (≥ grade2) does not occur frequently. In the case of platinum, especially, carboplatin, re-administering after hypersensitivity reaction should be done carefully though platinum is a key drug in patients with gynecologic malignancies.

    PubMed

  • 子宮平滑筋肉腫の新規バイオマーカーについて

    市村 友季

    産婦人科の進歩   64 ( 3 )   434 - 434   2012( ISSN:03708446

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  • A case of corpus adenosquamous carcinoma treated for cervical carcinoma

    INOUE Yutaka, ICHIMURA Tomoyuki, NAGASHIMA Aiko, WADA Natsuko, MORISHITA Masanari, KASAI Mari, FUKUDA Takeshi, YOSHIDA Hiroyuki, HASHIGUCHI Yasunori, MATSUMOTO Yoshinari, YASUI Tomoyo, SUMI Toshiyuki, ISHIKO Osamu

    ADVANCES IN OBSTETRICS AND GYNECOLOGY   64 ( 3 )   349 - 351   2012( ISSN:03708446

  • Potential role of LMP2 as tumor-suppressor defines new targets for uterine leiomyosarcoma therapy Reviewed

    Hayashi Takuma, Horiuchi Akiko, Sano Kenji, Hiraoka Nobuyoshi, Kasai Mari, Ichimura Tomoyuki, Sudo Tamotsu, Tagawa Yoh-ichi, Nishimura Ryuichiro, Ishiko Osamu, Kanai Yae, Yaegashi Nobuo, Aburatani Hiroyuki, Shiozawa Tanri, Konishi Ikuo

    SCIENTIFIC REPORTS   1   180   2011.12( ISSN:2045-2322

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    DOI: 10.1038/srep00180

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  • Involvement of proteasome β1i subunit, LMP2, on development of uterin leiomyosarcma. Reviewed

    Hayashi T, Horiuchi A, Sano K, Hiraoka N, Kasai M, Ichimura T, Nagase S, Ishiko O, Shiozawa T, Kanai Y, Yaegashi N, Aburatani H, Tonegawa S, Konishi I

    North American journal of medical sciences   3 ( 9 )   394 - 9   2011.09( ISSN:2250-1541

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    DOI: 10.4297/najms.2011.3394

    PubMed

  • Involvement of proteasome β1i subunit, LMP2, on development of uterin leiomyosarcma. Reviewed

    Hayashi T, Horiuchi A, Sano K, Hiraoka N, Kasai M, Ichimura T, Nagase S, Ishiko O, Shiozawa T, Kanai Y, Yaegashi N, Aburatani H, Tonegawa S, Konishi I

    North American journal of medical sciences   3 ( 9 )   394 - 9   2011.09( ISSN:2250-1541

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    DOI: 10.4297/najms.2011.3394

  • 当科における進行子宮頸癌に対する主治療前化学療法 Reviewed

    森下 真成, 角 俊幸, 中野 雄介, 笠井 真理, 梶谷 耕二, 福田 武史, 橋口 裕紀, 尾崎 宏治, 吉田 裕之, 市村 友季, 松本 佳也, 安井 智代, 本田 謙一, 石河 修

    「産婦人科の進歩」編集室 産婦人科の進歩   63 ( 3 )   359 - 361   2011.08( ISSN:0370-8446

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    70歳未満の子宮頸癌III期に対し、主治療前化学療法(NAC)を施行した72例(平均50.5歳:N群)と、同時化学放射線治療を主体とした39例(平均56.1歳:R群)の治療成績を比較した。年齢には両群間で有意差を認めたが、進行期、組織型に有意差はなく、全生存率にも有意差は認めなかった。次に、N群をNACにより腫瘍が縮小し手術施行・術後放射線治療を追加した46例(平均49.3歳:NAC+OP+R群)と、NAC後も手術施行できず放射線治療のみ行った26例(平均52.7歳:NAC+R群)に分け、R群と比較した。年齢には3群間で有意差を認めたが、進行期、組織型に有意差はなく、全生存率はNAC+OP+R群がNAC+R群に比較して有意に良好であった。進行子宮頸癌に対するNACは、手術を施行できれば予後改善につながる可能性があることが示唆された。

  • 当科における進行子宮頸癌に対する主治療前化学療法

    森下 真成, 角 俊幸, 中野 雄介, 笠井 真理, 梶谷 耕二, 福田 武史, 橋口 裕紀, 尾崎 宏治, 吉田 裕之, 市村 友季, 松本 佳也, 安井 智代, 本田 謙一, 石河 修

    産婦人科の進歩   63 ( 3 )   359 - 361   2011.08( ISSN:0370-8446

     More details

    70歳未満の子宮頸癌III期に対し、主治療前化学療法(NAC)を施行した72例(平均50.5歳:N群)と、同時化学放射線治療を主体とした39例(平均56.1歳:R群)の治療成績を比較した。年齢には両群間で有意差を認めたが、進行期、組織型に有意差はなく、全生存率にも有意差は認めなかった。次に、N群をNACにより腫瘍が縮小し手術施行・術後放射線治療を追加した46例(平均49.3歳:NAC+OP+R群)と、NAC後も手術施行できず放射線治療のみ行った26例(平均52.7歳:NAC+R群)に分け、R群と比較した。年齢には3群間で有意差を認めたが、進行期、組織型に有意差はなく、全生存率はNAC+OP+R群がNAC+R群に比較して有意に良好であった。進行子宮頸癌に対するNACは、手術を施行できれば予後改善につながる可能性があることが示唆された。

  • An Upstream Estrogen Response Element Linked to Exogenous p53 Tumor Suppressor Gene Expression Differentiates Effects of the Codon 72 Polymorphism Reviewed

    Honda Ken-ichi, Kajitani Koji, Nobeyama Hiroyuki, Kira Yukimi, Yabunaka Yoriko, Egami Mika, Zhi Xu, Fukuda Takeshi, Yoshida Hiroyuki, Matsumoto Yoshinari, Ichimura Tomoyuki, Yaui Tomoyo, Sumi Toshiyuki, Ishiko Osamu

    ASIAN PACIFIC JOURNAL OF CANCER PREVENTION   12 ( 4 )   865 - 868   2011( ISSN:1513-7368

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  • Neoadjuvant chemotherapy for advanced carcinoma of the uterine cervix Reviewed

    MORISHITA Masanari, ICHIMURA Tomoyuki, MATSUMOTO Yoshinari, YASUI Tomoyo, HONDA Kenichi, ISHIKO Osamu, SUMI Toshiyuki, NAKANO Yusuke, KASAI Mari, KAJITANI Koji, FUKUDA Takeshi, HASHIGUCHI Yasunori, OZAKI Koji, YOSHIDA Hiroyuki

    THE OBSTETRICAL GYNECOLOGICAL SOCIETY OF KINKI DISTRICT JAPAN, ADVANCES IN OBSTETRICS AND GYNECOLOGY   63 ( 3 )   359 - 361   2011( ISSN:0370-8446

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    DOI: 10.11437/sanpunosinpo.63.359

    CiNii Article

  • An upstream estrogen response element linked to exogenous p53 tumor suppressor gene expression differentiates effects of the codon 72 polymorphism. Reviewed

    Honda K, Kajitani K, Nobeyama H, Kira Y, Yabunaka Y, Egami M, Zhi X, Fukuda T, Yoshida H, Matsumoto Y, Ichimura T, Yaui T, Sumi T, Ishiko O

    Asian Pacific journal of cancer prevention : APJCP   12 ( 4 )   865 - 8   2011( ISSN:1513-7368

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    PubMed

  • Potential role of LMP2 as tumor-suppressor defines new targets for uterine leiomyosarcoma therapy Reviewed

    Takuma Hayashi, Akiko Horiuchi, Kenji Sano, Nobuyoshi Hiraoka, Mari Kasai, Tomoyuki Ichimura, Tamotsu Sudo, Yoh-Ichi Tagawa, Ryuichiro Nishimura, Osamu Ishiko, Yae Kanai, Nobuo Yaegashi, Hiroyuki Aburatani, Tanri Shiozawa, Ikuo Konishi

    Scientific Reports   1   180   2011( ISSN:2045-2322

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    Although the majority of smooth muscle neoplasms found in the uterus are benign, uterine leiomyosarcoma (LMS) is extremely malignant, with high rates of recurrence and metastasis. We earlier reported that mice with a homozygous deficiency for LMP2, an interferon (IFN)-γ-inducible factor, spontaneously develop uterine LMS. The IFN-γ pathway is important for control of tumor growth and invasion and has been implicated in several cancers. In this study, experiments with human and mouse uterine tissues revealed a defective LMP2 expression in human uterine LMS that was traced to the IFN-γ pathway and the specific effect of JAK-1 somatic mutations on the LMP2 transcriptional activation. Furthermore, analysis of a human uterine LMS cell line clarified the biological significance of LMP2 in malignant myometrium transformation and cell cycle, thus implicating LMP2 as an anti-tumorigenic candidate. This role of LMP2 as a tumor suppressor may lead to new therapeutic targets in human uterine LMS.

    DOI: 10.1038/srep00180

    PubMed

  • An upstream estrogen response element linked to exogenous p53 tumor suppressor gene expression differentiates effects of the codon 72 polymorphism. Reviewed

    Honda K, Kajitani K, Nobeyama H, Kira Y, Yabunaka Y, Egami M, Zhi X, Fukuda T, Yoshida H, Matsumoto Y, Ichimura T, Yaui T, Sumi T, Ishiko O

    Asian Pacific journal of cancer prevention : APJCP   12 ( 4 )   865 - 8   2011( ISSN:1513-7368

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    Publishing type:Research paper (scientific journal)  

  • An upstream estrogen response element linked to exogenous p53 tumor suppressor gene expression differentiates effects of the codon 72 polymorphism.

    Honda K, Kajitani K, Nobeyama H, Kira Y, Yabunaka Y, Egami M, Zhi X, Fukuda T, Yoshida H, Matsumoto Y, Ichimura T, Yaui T, Sumi T, Ishiko O

    Asian Pacific journal of cancer prevention : APJCP   12 ( 4 )   865 - 8   2011( ISSN:1513-7368

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  • An Upstream Estrogen Response Element Linked to Exogenous p53 Tumor Suppressor Gene Expression Differentiates Effects of the Codon 72 Polymorphism Reviewed

    Honda Ken-ichi, Kajitani Koji, Nobeyama Hiroyuki, Kira Yukimi, Yabunaka Yoriko, Egami Mika, Zhi Xu, Fukuda Takeshi, Yoshida Hiroyuki, Matsumoto Yoshinari, Ichimura Tomoyuki, Yaui Tomoyo, Sumi Toshiyuki, Ishiko Osamu

    ASIAN PACIFIC JOURNAL OF CANCER PREVENTION   12 ( 4 )   865 - 868   2011( ISSN:1513-7368

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    Publishing type:Research paper (scientific journal)  

  • Neoadjuvant chemotherapy for advanced carcinoma of the uterine cervix

    MORISHITA Masanari, SUMI Toshiyuki, NAKANO Yusuke, KASAI Mari, KAJITANI Koji, FUKUDA Takeshi, HASHIGUCHI Yasunori, OZAKI Koji, YOSHIDA Hiroyuki, ICHIMURA Tomoyuki, MATSUMOTO Yoshinari, YASUI Tomoyo, HONDA Kenichi, ISHIKO Osamu

    ADVANCES IN OBSTETRICS AND GYNECOLOGY   63 ( 3 )   359 - 361   2011( ISSN:03708446

  • 再発卵巣がんに対する治療方針決定のためのPET検査の意義 Reviewed

    森下 真成, 安井 智代, 笠井 真理, 梶谷 耕二, 吉田 裕之, 市村 友季, 松本 佳也, 角 俊幸, 本田 謙一, 石河 修

    「産婦人科の進歩」編集室 産婦人科の進歩   62 ( 3 )   296 - 298   2010.08( ISSN:0370-8446

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    再発卵巣癌に対し、PET検査による診断が有用であったと考えられる3症例について検討した。2例(64歳、60歳)は、再発の診断は腫瘍マーカーの上昇やCT・MRIなどにより得られ、再発部位を特定できたが、再発部位の診断はできなかった。1例(65歳)は、腫瘍マーカーの上昇により再発を疑ったものの、MRIやCTでは再発部位の特定や再発部位の診断ができなかった。全例、PET検査を追加することにより再発部位の特定・診断が可能となり、手術療法を選択することができた。腹水洗浄細胞診は陰性で、腹腔内に播種性病変もなく、その後は良好に経過した。再発卵巣癌に対し、腫瘍マーカー値、従来の画像検査にPET検査を組み合わせることにより、より効果的な個別治療法を選択できるものと考えられた。

  • 再発卵巣がんに対する治療方針決定のためのPET検査の意義

    森下 真成, 安井 智代, 笠井 真理, 梶谷 耕二, 吉田 裕之, 市村 友季, 松本 佳也, 角 俊幸, 本田 謙一, 石河 修

    産婦人科の進歩   62 ( 3 )   296 - 298   2010.08( ISSN:0370-8446

     More details

    再発卵巣癌に対し、PET検査による診断が有用であったと考えられる3症例について検討した。2例(64歳、60歳)は、再発の診断は腫瘍マーカーの上昇やCT・MRIなどにより得られ、再発部位を特定できたが、再発部位の診断はできなかった。1例(65歳)は、腫瘍マーカーの上昇により再発を疑ったものの、MRIやCTでは再発部位の特定や再発部位の診断ができなかった。全例、PET検査を追加することにより再発部位の特定・診断が可能となり、手術療法を選択することができた。腹水洗浄細胞診は陰性で、腹腔内に播種性病変もなく、その後は良好に経過した。再発卵巣癌に対し、腫瘍マーカー値、従来の画像検査にPET検査を組み合わせることにより、より効果的な個別治療法を選択できるものと考えられた。

  • 当院での卵巣粘液性腺癌の治療成績 Reviewed

    中野 雄介, 角 俊幸, 安部 佳代子, 梶谷 耕二, 吉田 愛, 吉田 裕之, 市村 友季, 松本 佳也, 安井 智代, 本田 謙一, 金岡 靖, 石河 修

    「産婦人科の進歩」編集室 産婦人科の進歩   62 ( 1 )   27 - 29   2010.02( ISSN:0370-8446

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    卵巣粘液性腺癌を対象に、予後における危険因子を後方視的に検討した。初回手術を施行した卵巣悪性腫瘍は218例で、うち粘液性腺癌は34例(15.6%)であった。進行期別には、I・II期の早期癌が全体の82.4%(28例)を占めた。III・IV期の進行癌は6例で、再発・再燃を83.3%(5例)に認めた。死亡症例(7例)には残存腫瘍が認められた。残存腫瘍径からみた平均生存期間は、残存腫瘍径が1cm以上(6例):35.3ヵ月、1cm以下(3例):25.0ヵ月で、両者に統計学的有意差はみられなかった。化学療法奏功率は22.2%であった。進行粘液性腺癌の予後改善のためには、手術における完全摘出の他、組織型別化学療法の確立、転移性卵巣癌と原発性卵巣癌の鑑別を行うための新たな診断法の開発等が必要であると考えられた。

  • 当院での卵巣粘液性腺癌の治療成績

    中野 雄介, 角 俊幸, 安部 佳代子, 梶谷 耕二, 吉田 愛, 吉田 裕之, 市村 友季, 松本 佳也, 安井 智代, 本田 謙一, 金岡 靖, 石河 修

    産婦人科の進歩   62 ( 1 )   27 - 29   2010.02( ISSN:0370-8446

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    卵巣粘液性腺癌を対象に、予後における危険因子を後方視的に検討した。初回手術を施行した卵巣悪性腫瘍は218例で、うち粘液性腺癌は34例(15.6%)であった。進行期別には、I・II期の早期癌が全体の82.4%(28例)を占めた。III・IV期の進行癌は6例で、再発・再燃を83.3%(5例)に認めた。死亡症例(7例)には残存腫瘍が認められた。残存腫瘍径からみた平均生存期間は、残存腫瘍径が1cm以上(6例):35.3ヵ月、1cm以下(3例):25.0ヵ月で、両者に統計学的有意差はみられなかった。化学療法奏功率は22.2%であった。進行粘液性腺癌の予後改善のためには、手術における完全摘出の他、組織型別化学療法の確立、転移性卵巣癌と原発性卵巣癌の鑑別を行うための新たな診断法の開発等が必要であると考えられた。

  • The significance of PET in the treatment of recurrent ovarian cancer Reviewed

    MORISHITA Masanari, ISHIKO Osamu, YASUI Tomoyo, KASAI Mari, KAJITANI Koji, YOSHIDA Hiroyuki, ICHIMURA Tomoyuki, MATSUMOTO Yoshinari, SUMI Toshiyuki, HONDA Kenichi

    THE OBSTETRICAL GYNECOLOGICAL SOCIETY OF KINKI DISTRICT JAPAN, ADVANCES IN OBSTETRICS AND GYNECOLOGY   62 ( 3 )   296 - 298   2010( ISSN:0370-8446

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    DOI: 10.11437/sanpunosinpo.62.296

    CiNii Article

  • Treatment results of the ovarian mucinous adenocarcinoma in our hospital Reviewed

    NAKANO Yusuke, HONDA Ken-ichi, KANAOKA Yasushi, ISHIKO Osamu, SUMI Toshiyuki, ABE Kayoko, KAJITANI Koji, YOSHIDA Chika, YOSHIDA Hiroyuki, ICHIMURA Tomoyuki, MATSUMOTO Yoshinari, YASUI Tomoyo

    THE OBSTETRICAL GYNECOLOGICAL SOCIETY OF KINKI DISTRICT JAPAN, ADVANCES IN OBSTETRICS AND GYNECOLOGY   62 ( 1 )   27 - 29   2010( ISSN:0370-8446

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    DOI: 10.11437/sanpunosinpo.62.27

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  • The significance of PET in the treatment of recurrent ovarian cancer

    MORISHITA Masanari, YASUI Tomoyo, KASAI Mari, KAJITANI Koji, YOSHIDA Hiroyuki, ICHIMURA Tomoyuki, MATSUMOTO Yoshinari, SUMI Toshiyuki, HONDA Kenichi, ISHIKO Osamu

    ADVANCES IN OBSTETRICS AND GYNECOLOGY   62 ( 3 )   296 - 298   2010( ISSN:03708446

  • Treatment results of the ovarian mucinous adenocarcinoma in our hospital

    NAKANO Yusuke, SUMI Toshiyuki, ABE Kayoko, KAJITANI Koji, YOSHIDA Chika, YOSHIDA Hiroyuki, ICHIMURA Tomoyuki, MATSUMOTO Yoshinari, YASUI Tomoyo, HONDA Ken-ichi, KANAOKA Yasushi, ISHIKO Osamu

    ADVANCES IN OBSTETRICS AND GYNECOLOGY   62 ( 1 )   27 - 29   2010( ISSN:03708446

  • A scoring system for histopathologic and immunohistochemical evaluations of uterine leiomyosarcomas Reviewed

    Yoshida Chika, Ichimura Tomoyuki, Kawamura Naoki, Nakano Akemi, Kasai Mari, Sumi Toshiyuki, Ishiko Osamu

    ONCOLOGY REPORTS   22 ( 4 )   725 - 731   2009.10( ISSN:1021-335X

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    DOI: 10.3892/or_00000493

    PubMed

  • A scoring system for histopathologic and immunohistochemical evaluations of uterine leiomyosarcomas Reviewed

    Chika Yoshida, Tomoyuki Ichimura, Naoki Kawamura, Akemi Nakano, Mari Kasai, Toshiyuki Sumi, Osamu Ishiko

    ONCOLOGY REPORTS   22 ( 4 )   725 - 31   2009.10( ISSN:1021-335X

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    Uterine leiomyosarcomas (LMS) are difficult to distinguish from benign leiomyomas without surgery. In this study we performed transcervical needle biopsy on 475 patients, 8 LMS patients and 467 patients with non-sarcomas (non-LMS) in a high-risk group for LMS, and evaluated whether examinations performed with Ki-67 and CD34 immunohistochemical analyses in addition to the standard hematoxylin-eosin (H&E)-stained sections would improve preoperative diagnostic precision of the uterine smooth muscle tumors. Histopathologic analysis included three factors: degree of cytologic atypia, mitotic index and coagulative tumor cell necrosis (CTCN). We also evaluated cell proliferation with Ki-67 expression. In cases of suspected CTCN, we examined CD34 expression and counted positive blood vessels in the necrotic area. Three of the 8 LMS cases satisfied the diagnostic criteria of LMS by histopathologic evaluation with H&E-stained sections. We made a score list based on these analyses; scores for LMS specimens ranged from 6-14 points; non-LMS specimens scored 0-2 points. At the cut-off score of 6 points, the positive predictive value to distinguish LMS from non-LMS was 100%, showing that this scoring system, is a useful method for preoperative differentiation between LMS and non-LMS tumors.

    DOI: 10.3892/or_00000493

    PubMed

  • Approaches of a palliative care team to gynecologic cancer patients in our hospital Reviewed

    HONDA Ken-ichi, KANAOKA Yasushi, ISHIKO Osamu, NAKANO Yusuke, ABE Kayoko, KAJITANI Koji, YOSHIDA Chika, YOSHIDA Hiroyuki, MATSUMOTO Yoshinari, ICHIMURA Tomoyuki, SUMI Toshiyuki

    THE OBSTETRICAL GYNECOLOGICAL SOCIETY OF KINKI DISTRICT JAPAN, ADVANCES IN OBSTETRICS AND GYNECOLOGY   61 ( 3 )   264 - 265   2009( ISSN:0370-8446

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    DOI: 10.11437/sanpunosinpo.61.264

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  • Salvage chemotherapy with paclitaxel/carboplatin for docetaxel/carboplatin-resistant ovarian cancer Reviewed

    YOSHIDA Hiroyuki, KANAOKA Yasushi, ISHIKO Osamu, SUMI Toshiyuki, KAJITANI Koji, YOSHIDA Chika, NOBEYAMA Hiroyuki, ICHIMURA Tomoyuki, MATSUMOTO Yoshinari, YASUI Tomoyo, HONDA Kenichi

    THE OBSTETRICAL GYNECOLOGICAL SOCIETY OF KINKI DISTRICT JAPAN, ADVANCES IN OBSTETRICS AND GYNECOLOGY   61 ( 1 )   35 - 37   2009( ISSN:0370-8446

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    DOI: 10.11437/sanpunosinpo.61.35

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  • Salvage chemotherapy with paclitaxel/carboplatin for docetaxel/carboplatin-resistant ovarian cancer Reviewed

    YOSHIDA Hiroyuki, SUMI Toshiyuki, KAJITANI Koji, YOSHIDA Chika, NOBEYAMA Hiroyuki, ICHIMURA Tomoyuki, MATSUMOTO Yoshinari, YASUI Tomoyo, HONDA Kenichi, KANAOKA Yasushi, ISHIKO Osamu

    ADVANCES IN OBSTETRICS AND GYNECOLOGY   61 ( 1 )   35 - 37   2009( ISSN:03708446

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    DOI: 10.11437/sanpunosinpo.61.35

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  • Approaches of a palliative care team to gynecologic cancer patients in our hospital Reviewed

    HONDA Ken-ichi, NAKANO Yusuke, ABE Kayoko, KAJITANI Koji, YOSHIDA Chika, YOSHIDA Hiroyuki, MATSUMOTO Yoshinari, ICHIMURA Tomoyuki, SUMI Toshiyuki, KANAOKA Yasushi, ISHIKO Osamu

    ADVANCES IN OBSTETRICS AND GYNECOLOGY   61 ( 3 )   264 - 265   2009( ISSN:03708446

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    DOI: 10.11437/sanpunosinpo.61.264

    CiNii Article

  • The outpatient chemotherapy in gynecologic oncology in our hospital Reviewed

    MATSUMOTO Yoshinari, HONDA Ken-ichi, KANAOKA Yasushi, ISHIKO Osamu, YOSHIDA Chika, FUKUDA Takeshi, KAJITANI Koji, TAMURA Miho, YOSHIDA Hiroyuki, ICHIMURA Tomoyuki, YASUI Tomoyo, SUMI Toshiyuki

    THE OBSTETRICAL GYNECOLOGICAL SOCIETY OF KINKI DISTRICT JAPAN, ADVANCES IN OBSTETRICS AND GYNECOLOGY   60 ( 2 )   123 - 125   2008( ISSN:0370-8446

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    DOI: 10.11437/sanpunosinpo.60.123

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  • The outpatient chemotherapy in gynecologic oncology in our hospital Reviewed

    MATSUMOTO Yoshinari, YOSHIDA Chika, FUKUDA Takeshi, KAJITANI Koji, TAMURA Miho, YOSHIDA Hiroyuki, ICHIMURA Tomoyuki, YASUI Tomoyo, SUMI Toshiyuki, HONDA Ken-ichi, KANAOKA Yasushi, ISHIKO Osamu

    ADVANCES IN OBSTETRICS AND GYNECOLOGY   60 ( 2 )   123 - 125   2008( ISSN:03708446

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    DOI: 10.11437/sanpunosinpo.60.123

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  • O-55 化学放射線療法が著効した子宮頸部小細胞癌の1例(子宮頸部5, 第48回日本臨床細胞学会総会) Reviewed

    吉田 愛, 市村 友季, 本田 謙一, 石河 修, 佐々木 政臣, 若狭 研一

    特定非営利活動法人日本臨床細胞学会 日本臨床細胞学会雑誌   46 ( 1 )   2007.03( ISSN:03871193

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    CiNii Article

  • O-55 化学放射線療法が著効した子宮頸部小細胞癌の1例(子宮頸部5, 第48回日本臨床細胞学会総会) Reviewed

    吉田 愛, 市村 友季, 本田 謙一, 石河 修, 佐々木 政臣, 若狭 研一

    特定非営利活動法人日本臨床細胞学会 日本臨床細胞学会雑誌   46 ( 1 )   2007.03( ISSN:0387-1193

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  • O-55 化学放射線療法が著効した子宮頸部小細胞癌の1例(子宮頸部5, 第48回日本臨床細胞学会総会)

    吉田 愛, 市村 友季, 本田 謙一, 石河 修, 佐々木 政臣, 若狭 研一

    日本臨床細胞学会雑誌   46 ( 1 )   166   2007.03( ISSN:03871193

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  • Clinical evaluation of the young uterine cervical cancer cases in our hospital Reviewed

    FUKUDA Takeshi, YASUI Tomoyo, HONDA Kenichi, KANAOKA Yasushi, ISHIKO Osamu, SUMI Toshiyuki, NORIYUKI Maiko, KAJITANI Koji, YOSHIDA Chika, NOBEYAMA Hiroyuki, YOSHIDA Hiroyuki, ICHIMURA Tomoyuki, MATSUMOTO Yoshinari

    THE OBSTETRICAL GYNECOLOGICAL SOCIETY OF KINKI DISTRICT JAPAN, ADVANCES IN OBSTETRICS AND GYNECOLOGY   59 ( 2 )   124 - 126   2007( ISSN:0370-8446

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    DOI: 10.11437/sanpunosinpo.59.124

    CiNii Article

  • Fertility-preserving treatment with high-dose progestogen for endometrial carcinoma in our department Reviewed

    HONDA Ken-ichi, ISHIKO Osamu, MATSUMOTO Yoshinari, ICHIMURA Tomoyuki, YASUI Tomoyo, SUMI Toshiyuki, KANAOKA Yasushi, TACHIBANA Daisuke, OZAKI Koji, NAKAI Yuichiro

    THE OBSTETRICAL GYNECOLOGICAL SOCIETY OF KINKI DISTRICT JAPAN, ADVANCES IN OBSTETRICS AND GYNECOLOGY   59 ( 4 )   293 - 294   2007( ISSN:0370-8446

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    DOI: 10.11437/sanpunosinpo.59.293

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  • Conservative management for myoma uteri Reviewed

    ICHIMURA Tomoyuki

    THE OBSTETRICAL GYNECOLOGICAL SOCIETY OF KINKI DISTRICT JAPAN, ADVANCES IN OBSTETRICS AND GYNECOLOGY   59 ( 1 )   52 - 56   2007( ISSN:0370-8446

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    Publishing type:Research paper (scientific journal)   Kind of work:Single Work  

    DOI: 10.11437/sanpunosinpo.59.52

    CiNii Article

  • Conservative management for myoma uteri Reviewed

    ICHIMURA Tomoyuki

    ADVANCES IN OBSTETRICS AND GYNECOLOGY   59 ( 1 )   52 - 56   2007( ISSN:03708446

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    DOI: 10.11437/sanpunosinpo.59.52

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  • Clinical evaluation of the young uterine cervical cancer cases in our hospital

    FUKUDA Takeshi, SUMI Toshiyuki, NORIYUKI Maiko, KAJITANI Koji, YOSHIDA Chika, NOBEYAMA Hiroyuki, YOSHIDA Hiroyuki, ICHIMURA Tomoyuki, MATSUMOTO Yoshinari, YASUI Tomoyo, HONDA Kenichi, KANAOKA Yasushi, ISHIKO Osamu

    ADVANCES IN OBSTETRICS AND GYNECOLOGY   59 ( 2 )   124 - 126   2007( ISSN:03708446

  • Fertility-preserving treatment with high-dose progestogen for endometrial carcinoma in our department

    HONDA Ken-ichi, MATSUMOTO Yoshinari, ICHIMURA Tomoyuki, YASUI Tomoyo, SUMI Toshiyuki, KANAOKA Yasushi, TACHIBANA Daisuke, OZAKI Koji, NAKAI Yuichiro, ISHIKO Osamu

    ADVANCES IN OBSTETRICS AND GYNECOLOGY   59 ( 4 )   293 - 294   2007( ISSN:03708446

  • Involvement of SUMO modification in MBD1- and MCAF1-mediated heterochromatin formation Reviewed

    Uchimura Yasuhiro, Ichimura Takaya, Uwada Junsuke, Tachibana Taro, Sugahara Satoko, Nakao Mitsuyoshi, Saitoh Hisato

    JOURNAL OF BIOLOGICAL CHEMISTRY   281 ( 32 )   23180 - 23190   2006.08

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1074/jbc.M602280200

  • Involvement of SUMO modification in MBD1- and MCAF1-mediated heterochromatin formation Reviewed

    Yasuhiro Uchimura, Takaya Ichimura, Junsuke Uwada, Taro Tachibana, Satoko Sugahara, Mitsuyoshi Nakao, Hisato Saitoh

    JOURNAL OF BIOLOGICAL CHEMISTRY   281 ( 32 )   23180 - 23190   2006.08( ISSN:0021-9258

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    Small ubiquitin-related modifiers, SUMO-2/3 and SUMO-1, are involved in gene regulation and nuclear structures. However, little is known about the roles of SUMO, in heterochromatin formation of mammalian cells. Here we demonstrate that SUMOs directly interact with human MCAF1, which forms complexes with either the methyl-CpG-binding protein MBD1 or SETDB1, which trimethylates histone H3 at lysine 9 (H3-K9) in the presence of MCAF1. Modification of MBD1 with either SUMO-2/3 or SUMO-1 facilitated the interaction between MBD1 and MCAF1, suggesting that SUMOylation links the methylation of DNA and histones. In a cultured human cell line, SUMOs were localized in MBD1- and MCAF1-containing heterochromatin regions that were enriched in trimethyl-H3-K9 and the heterochromatin proteins HP1 beta and HP1 gamma. Specific knockdown of either SUMO-2/3 or SUMO-1 induced dissociation of MCAF1, trimethyl-H3-K9, and the HP1 proteins from the MBD1-containing heterochromatin foci, suggesting a requirement for SUMOs for heterochromatin assembly. These findings provide insights into the roles of SUMOylation in the regulation of heterochromatin formation and gene silencing.

    DOI: 10.1074/jbc.M602280200

  • O-37 腟原発悪性黒色腫の1例(その他の女性器,一般演題・口演,第47回日本臨床細胞学会総会(春期大会)) Reviewed

    吉田 愛, 市村 友季, 本田 謙一, 佐々木 政臣, 若狭 朋子, 若狭 研一, 石河 修

    特定非営利活動法人日本臨床細胞学会 日本臨床細胞学会雑誌   45 ( 1 )   2006.03( ISSN:03871193

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    CiNii Article

  • O-37 腟原発悪性黒色腫の1例(その他の女性器,一般演題・口演,第47回日本臨床細胞学会総会(春期大会))

    吉田 愛, 市村 友季, 本田 謙一, 佐々木 政臣, 若狭 朋子, 若狭 研一, 石河 修

    日本臨床細胞学会雑誌   45 ( 1 )   191   2006.03( ISSN:03871193

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  • O-37 腟原発悪性黒色腫の1例(その他の女性器,一般演題・口演,第47回日本臨床細胞学会総会(春期大会)) Reviewed

    吉田 愛, 市村 友季, 本田 謙一, 佐々木 政臣, 若狭 朋子, 若狭 研一, 石河 修

    特定非営利活動法人日本臨床細胞学会 日本臨床細胞学会雑誌   45 ( 1 )   2006.03( ISSN:0387-1193

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  • Examination of the clinical effect and the adverse effect of concurrent chemoradiation therapy for invasive uterine cervical cancer Reviewed

    FUKUDA Takeshi, HIRAI Kozo, HONDA Ken-ichi, KANAOKA Yasushi, ISHIKO Osamu, SUMI Toshiyuki, TSUKIOKA Miho, NORIYUKI Maiko, MISUGI Takuya, MISUGI Fumiko, ICHIMURA Tomoyuki, MATSUMOTO Yoshinari, YASUI Tomoyo

    THE OBSTETRICAL GYNECOLOGICAL SOCIETY OF KINKI DISTRICT JAPAN, ADVANCES IN OBSTETRICS AND GYNECOLOGY   58 ( 1 )   45 - 47   2006( ISSN:0370-8446

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    DOI: 10.11437/sanpunosinpo.58.45

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  • Granulosa cell tumor in our hospital Reviewed

    MATSUMOTO Yoshinari, SUMI Toshiyuki, KANAOKA Yasushi, Honda Ken-ichi, ISHIKO Osamu, TSUKIOKA Miho, NORIYUKI Maiko, NISHIMOTO Sachiyo, MISUGI Takuya, MISUGI Fumiko, YOSHIDA Hiroyuki, ICHIMURA Tomoyuki, YASUI Tomoyo

    THE OBSTETRICAL GYNECOLOGICAL SOCIETY OF KINKI DISTRICT JAPAN, ADVANCES IN OBSTETRICS AND GYNECOLOGY   58 ( 4 )   397 - 398   2006( ISSN:0370-8446

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    DOI: 10.11437/sanpunosinpo.58.397

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  • Granulosa cell tumor in our hospital Reviewed

    MATSUMOTO Yoshinari, TSUKIOKA Miho, NORIYUKI Maiko, NISHIMOTO Sachiyo, MISUGI Takuya, MISUGI Fumiko, YOSHIDA Hiroyuki, ICHIMURA Tomoyuki, YASUI Tomoyo, SUMI Toshiyuki, KANAOKA Yasushi, Honda Ken-ichi, ISHIKO Osamu

    ADVANCES IN OBSTETRICS AND GYNECOLOGY   58 ( 4 )   397 - 398   2006( ISSN:03708446

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    DOI: 10.11437/sanpunosinpo.58.397

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  • Examination of the clinical effect and the adverse effect of concurrent chemoradiation therapy for invasive uterine cervical cancer

    FUKUDA Takeshi, SUMI Toshiyuki, TSUKIOKA Miho, NORIYUKI Maiko, MISUGI Takuya, MISUGI Fumiko, ICHIMURA Tomoyuki, MATSUMOTO Yoshinari, YASUI Tomoyo, HIRAI Kozo, HONDA Ken-ichi, KANAOKA Yasushi, ISHIKO Osamu

    ADVANCES IN OBSTETRICS AND GYNECOLOGY   58 ( 1 )   45 - 47   2006( ISSN:03708446

  • 卵管癌7症例の検討(卵巣・その他2-(9), 第44回日本臨床細胞学会秋期大会) Reviewed

    本田 謙一, 西本 幸代, 吉田 愛, 市村 友季, 森村 美奈, 川村 直樹, 石河 修, 佐々木 政臣, 若狹 朋子, 若狭 研一

    特定非営利活動法人日本臨床細胞学会 日本臨床細胞学会雑誌   44 ( 2 )   2005.09( ISSN:03871193

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  • 卵管癌7症例の検討(卵巣・その他2-(9), 第44回日本臨床細胞学会秋期大会)

    本田 謙一, 西本 幸代, 吉田 愛, 市村 友季, 森村 美奈, 川村 直樹, 石河 修, 佐々木 政臣, 若狹 朋子, 若狭 研一

    日本臨床細胞学会雑誌   44 ( 2 )   476   2005.09( ISSN:03871193

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  • 卵管癌7症例の検討(卵巣・その他2-(9), 第44回日本臨床細胞学会秋期大会) Reviewed

    本田 謙一, 西本 幸代, 吉田 愛, 市村 友季, 森村 美奈, 川村 直樹, 石河 修, 佐々木 政臣, 若狹 朋子, 若狭 研一

    特定非営利活動法人日本臨床細胞学会 日本臨床細胞学会雑誌   44 ( 2 )   2005.09( ISSN:0387-1193

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  • 経子宮頚管的針生検による子宮肉腫の診断 Reviewed

    市村 友季, 石河 修, 川村 直樹

    日本婦人科腫瘍学会雑誌 = The journal of the Japan Society of Gynecologic Oncology   23 ( 1 )   79 - 84   2005.01( ISSN:13478559

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  • 経子宮頚管的針生検による子宮肉腫の診断 Reviewed

    市村 友季, 石河 修, 川村 直樹

    日本婦人科腫瘍学会雑誌 = The journal of the Japan Society of Gynecologic Oncology   23 ( 1 )   79 - 84   2005.01( ISSN:1347-8559

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  • 経子宮頚管的針生検による子宮肉腫の診断

    市村 友季, 石河 修, 川村 直樹

    日本婦人科腫瘍学会雑誌 = The journal of the Japan Society of Gynecologic Oncology   23 ( 1 )   79 - 84   2005.01( ISSN:13478559

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  • Diagnosis of uterine sarcoma in needle biopsy specimens.

    23 ( 1 )   79 - 84   2005

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  • Clinical analysis of thromboembolic complications in patients with clear cell adenocarcinoma of the ovary Reviewed

    KITAOKA Miho, ICHIMURA Tomoyuki, YASUI Tomoyo, SUMI Toshiyuki, HIRAI Kozo, HONDA Ken-ichi, KANAOKA Yasushi, ISHIKO Osamu, MATSUMOTO Yoshinari, TAHARA Mie, CHANG Yangsil, KATO Makiko, FUKUDA Takeshi, NORIYUKI Maiko, MISUGI Takuya, MISUGI Fumiko

    THE OBSTETRICAL GYNECOLOGICAL SOCIETY OF KINKI DISTRICT JAPAN, ADVANCES IN OBSTETRICS AND GYNECOLOGY   57 ( 2 )   164 - 167   2005( ISSN:0370-8446

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    DOI: 10.11437/sanpunosinpo.57.164

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  • Clinical analysis of thromboembolic complications in patients with clear cell adenocarcinoma of the ovary

    KITAOKA Miho, MATSUMOTO Yoshinari, TAHARA Mie, CHANG Yangsil, KATO Makiko, FUKUDA Takeshi, NORIYUKI Maiko, MISUGI Takuya, MISUGI Fumiko, ICHIMURA Tomoyuki, YASUI Tomoyo, SUMI Toshiyuki, HIRAI Kozo, HONDA Ken-ichi, KANAOKA Yasushi, ISHIKO Osamu

    ADVANCES IN OBSTETRICS AND GYNECOLOGY   57 ( 2 )   164 - 167   2005( ISSN:03708446

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Books and Other Publications

MISC

  • 新規診断法・治療法の確立に向けて 子宮間葉性腫瘍に対する分子病理学

    林 琢磨, 市村 友季, 油谷 浩幸, 利根川 進, 八重樫 伸生, 小西 郁生

    未病と抗老化   31   45 - 49   2022.11( ISSN:1347-667X

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    子宮平滑筋腫は,子宮の平滑筋層に発生する良性腫瘍である.子宮平滑筋腫の発生・増大にはエストロゲンが関与していて,閉経前には症状が強かった患者でも,閉経後には子宮平滑筋腫が著明に縮小する.しかし,子宮平滑筋腫の細胞は,多種多様の性質を有しているため,実臨床で,様々な子宮平滑筋腫の病態が,認められる.静脈内平滑筋腫症(Intravenous Leiomyomatosis,以下IVL)は,平滑筋組織が静脈内へ発育伸展する比較的稀な良性腫瘍である.静脈内平滑筋腫症は,組織学的には良性であるが,時に下大静脈,心臓内まで連続的に広がり,突然死の原因ともなり得る重要な疾患である.また,良性転移性平滑筋腫(Benign metastasizing leiomyoma,BML)は,子宮平滑筋腫瘍の既往のある女性に,遠隔臓器に良性平滑筋腫の転移巣が認められる病態である.良性転移性平滑筋腫では,肺への転移が最も多く認められる.子宮平滑筋腫の発生の原因として,いくつかの遺伝子・染色体異常(12q染色体を含む転座や再構成等の変異,7q遺伝子の欠損)が,認められているが,発症機序は,明らかにされていない.本レビューでは,転移が認められる子宮平滑筋腫について最新の情報を加えて,考察を行う.(著者抄録)

  • 未病と抗老化(Vol.30:36-40) 広範囲の哺乳綱に属する生き物へのSARS-CoV-2の感染拡大の危惧とCOVID-19の治療

    林 琢磨, 宇良 敬, 安彦 郁, 天野 泰彰, 市村 友季, 佐野 健司, 金井 栄, 油谷 浩幸, Gur G, Zharhary D, 万代 昌紀, 八重樫 伸生, 小西 郁生

    未病と抗老化   30   36 - 40   2021.11( ISSN:1347-667X

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    タイ東部の野生生物保護区に生息するコウモリから重症急性呼吸器症候群コロナウイルス2(SARS-CoV-2)関連コロナウイルスが検出された。このコウモリとタイ南部の野生動物検問所で得られたセンザンコウは、SARS-CoV-2に対する中和抗体を保有していることが分かった。これらの知見により、コウモリとセンザンコウに由来するSARS-CoV-2関連コロナウイルスの存在を確認できる領域が特定された。さらに、人獣共通感染症であるCOVID-19は、大型類人猿においても認められている。これまで、米国において、COVID-19の症状が認められたニシローランドゴリラへのカクテル抗体療法による治療が行われた。つまり、SARS-CoV-2とその変異体は、広範囲の哺乳綱に属する生き物に感染拡大している可能性が考えられる。そのため、アフリカの各国政府は、先進国と同様にアフリカの保護地区で生育している野生動物へのCOVID-19感染拡大に対する予防対策に苦悩している。現在の実臨床で、抗体カクテル療法において、COVID-19に対して奏効性が認められているが、抗体カクテル療法の処方時期は、限定されている。新たなSARS-CoV-2 variantの出現を考えると、新規の抗SARS-CoV-2に対する薬剤を含むCOVID-19治療法の確立が望まれる。(著者抄録)

  • 【これでわかる 婦人科稀少腫瘍】外陰腫瘍 悪性黒色腫

    市村 友季, 角 俊幸

    産科と婦人科   88 ( 2 )   223 - 229   2021.02( ISSN:0386-9792

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    産婦人科医として悪性黒色腫に遭遇する機会は極めて少ないが、女性生殖器に発生する悪性黒色腫は、その部位から診断は産婦人科医が行う可能性が高い。女性生殖器の悪性黒色腫は粘膜型で、皮膚悪性黒色腫に比較し予後不良のため術後補助療法を必要とすることも多いが、悪性黒色腫に対する薬物療法は次々に新しい治療が承認され飛躍的進歩を遂げている。産婦人科医にとって"まれ"だが"革新的"な腫瘍である悪性黒色腫について解説する。(著者抄録)

  • コロナと未病 感染拡大する新型コロナウイルス感染症 コウモリがヒトにウイルスを感染させる理由

    林 琢磨, 宇良 敬, 安彦 郁, 天野 泰彰, 市村 友季, 佐野 健司, 金井 栄, 油谷 浩幸, Gur G, Zharhary D, 万代 昌紀, 八重樫 伸生, 小西 郁生

    未病と抗老化   29   56 - 61   2020.11( ISSN:1347-667X

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    2020年5月8日、世界保健機関(WHO)の感染症専門家であるエンバレク氏は、最初にコロナウイルス病2019(COVID-19:coronavirus disease-2019)が確認された中国湖北省武漢市の卸売市場が新重症急性呼吸器症候群(SARS:severe acute respiratory syndrome)を引き起こすコロナウイルス(SARS-CoV:SARS-coronavirus)2型(SARS-CoV-2)の感染拡大の一因となったとの見方を示した。人間とコウモリの生活圏が近い地域では、コウモリが媒介する感染症が流行することがあり、エボラ出血熱や中東呼吸器症候群(MERS:Middle East Respiratory Syndrome)以外に、狂犬病や新興感染症(近年発見されたウイルスによる感染症)などが確認されている。これらの感染症は、人間以外の哺乳類にとって高い致死性を有している。しかしながら、感染保菌しているコウモリが死に至らない理由はわかっていなかった。本論文では、なぜコウモリは人にウイルスを感染させるのかという疑問に対する理由について、最近の人獣共通感染症の知見を含め解説する。(著者抄録)

  • 経子宮頸管的針生検 子宮非上皮性領域に発生する病変の生検診断

    市村 友季

    Medical Technology   48 ( 3 )   301 - 308   2020.03( ISSN:0389-1887

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    子宮の非上皮性領域に発生する腫瘤は、産婦人科で通常行う細胞診や生検では診断が困難であることが多いため、MRIが診断のために行われるおもな検査手技となる。しかしながらMRIは画像診断であるため診断の確定には至らず、画像のみでは診断に悩む症例も存在する。我々はこのような腫瘤に対し針生検を行うことで診断を確定、あるいは診断の一助としてその後の治療方針決定を行っている。本稿では我々が行う針生検の手技、結果判定方法について解説し、これまでの成績などを提示する。(著者抄録)

  • 加齢と造腫瘍における免疫プロテアソームの活性化の変化 Reviewed

    林 琢磨, 市村 友季, 佐野 健司, 金井 栄, 油谷 浩幸, Gur G, Zharhary D, 利根川 進, 八重樫 伸生, 小西 郁生

    (一財)博慈会老人病研究所 未病と抗老化   28   77 - 81   2019.11( ISSN:1347-667X

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    これまでの研究史において、イムノプロテアソームは、免疫にとって重要である主要組織適合性複合体による抗原提示のためのペプチド産生における生理学的役割について主に見られてきた。しかしながら、最近の研究成果は、免疫プロテアソームが恒常性に、そして特にストレスおよび疾患の間の酸化的に損傷を受けたタンパク質の排除に非常に重要であることを示している。タンパク質凝集物を特徴とする疾患もまた免疫プロテアソームの欠陥に関連しているので、タンパク質分解における免疫プロテアソームの重要性はより明白になってきている。さらに、免疫プロテアソーム特異的サブユニット分子内の突然変異または多型によって定義される疾患が臨床学的に現在存在しており、さらにサイトカインシグナル伝達およびタンパク質恒常性において、免疫プロテアソームの重要な役割が示唆されている。このレビューの目的は、タンパク質の品質管理や不要なタンパク質の分解における免疫プロテアソームの重要性、および疾患や加齢に伴う免疫プロテアソームの調節異常を起因とした疾患の発症についての理解を深めることです。(著者抄録)

  • 加齢と造腫瘍における免疫プロテアソームの活性化の変化 Reviewed

    林 琢磨, 市村 友季, 佐野 健司, 金井 栄, 油谷 浩幸, Gur G, Zharhary D, 利根川 進, 八重樫 伸生, 小西 郁生

    (一財)博慈会老人病研究所 未病と抗老化   28   77 - 81   2019.11( ISSN:1347-667X

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    これまでの研究史において、イムノプロテアソームは、免疫にとって重要である主要組織適合性複合体による抗原提示のためのペプチド産生における生理学的役割について主に見られてきた。しかしながら、最近の研究成果は、免疫プロテアソームが恒常性に、そして特にストレスおよび疾患の間の酸化的に損傷を受けたタンパク質の排除に非常に重要であることを示している。タンパク質凝集物を特徴とする疾患もまた免疫プロテアソームの欠陥に関連しているので、タンパク質分解における免疫プロテアソームの重要性はより明白になってきている。さらに、免疫プロテアソーム特異的サブユニット分子内の突然変異または多型によって定義される疾患が臨床学的に現在存在しており、さらにサイトカインシグナル伝達およびタンパク質恒常性において、免疫プロテアソームの重要な役割が示唆されている。このレビューの目的は、タンパク質の品質管理や不要なタンパク質の分解における免疫プロテアソームの重要性、および疾患や加齢に伴う免疫プロテアソームの調節異常を起因とした疾患の発症についての理解を深めることです。(著者抄録)

  • 加齢と造腫瘍における免疫プロテアソームの活性化の変化

    林 琢磨, 市村 友季, 佐野 健司, 金井 栄, 油谷 浩幸, Gur G, Zharhary D, 利根川 進, 八重樫 伸生, 小西 郁生

    未病と抗老化   28   77 - 81   2019.11( ISSN:1347-667X

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    これまでの研究史において、イムノプロテアソームは、免疫にとって重要である主要組織適合性複合体による抗原提示のためのペプチド産生における生理学的役割について主に見られてきた。しかしながら、最近の研究成果は、免疫プロテアソームが恒常性に、そして特にストレスおよび疾患の間の酸化的に損傷を受けたタンパク質の排除に非常に重要であることを示している。タンパク質凝集物を特徴とする疾患もまた免疫プロテアソームの欠陥に関連しているので、タンパク質分解における免疫プロテアソームの重要性はより明白になってきている。さらに、免疫プロテアソーム特異的サブユニット分子内の突然変異または多型によって定義される疾患が臨床学的に現在存在しており、さらにサイトカインシグナル伝達およびタンパク質恒常性において、免疫プロテアソームの重要な役割が示唆されている。このレビューの目的は、タンパク質の品質管理や不要なタンパク質の分解における免疫プロテアソームの重要性、および疾患や加齢に伴う免疫プロテアソームの調節異常を起因とした疾患の発症についての理解を深めることです。(著者抄録)

  • 筋腫に内膜症を合併した高度癒着例に対する腹腔鏡下子宮全摘術のポイントとコツは? ダグラス窩閉塞に対するアプローチが重要である Reviewed

    松本 貴, 市村 友季

    (株)日本医事新報社 日本医事新報   ( 4947 )   62 - 63   2019.02( ISSN:0385-9215

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  • 筋腫に内膜症を合併した高度癒着例に対する腹腔鏡下子宮全摘術のポイントとコツは? ダグラス窩閉塞に対するアプローチが重要である

    松本 貴, 市村 友季

    日本医事新報   ( 4947 )   62 - 63   2019.02( ISSN:0385-9215

  • 筋腫に内膜症を合併した高度癒着例に対する腹腔鏡下子宮全摘術のポイントとコツは? ダグラス窩閉塞に対するアプローチが重要である Reviewed

    松本 貴, 市村 友季

    (株)日本医事新報社 日本医事新報   ( 4947 )   62 - 63   2019.02( ISSN:0385-9215

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  • 悪性黒色腫について Reviewed

    市村 友季

    「産婦人科の進歩」編集室 産婦人科の進歩   69 ( 1 )   60 - 62   2017.02( ISSN:0370-8446

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  • 悪性黒色腫について Reviewed

    市村 友季

    「産婦人科の進歩」編集室 産婦人科の進歩   69 ( 1 )   60 - 62   2017.02( ISSN:0370-8446

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  • 悪性黒色腫について

    市村 友季

    産婦人科の進歩   69 ( 1 )   60 - 62   2017.02( ISSN:0370-8446

  • 女性外陰部扁平上皮癌に繰り返し発生したLucilia sericataとSarcophaga crassipalpisによるハエウジ病(Repeated myiasis in a female vulvar squamous cell carcinoma caused by Lucilia sericata and Sarcophaga crassipalpis) Reviewed

    Hiraoka Hiroyuki, Ozawa Toshiyuki, Sowa-Osako Junko, Ichimura Tomoyuki, Kimata-Teramoto Isao, Isozumi Rie, Kaneko Akira, Tsuruta Daisuke

    John Wiley & Sons Australia, Ltd The Journal of Dermatology   42 ( 8 )   840 - 841   2015.08( ISSN:0385-2407

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  • 女性外陰部扁平上皮癌に繰り返し発生したLucilia sericataとSarcophaga crassipalpisによるハエウジ病(Repeated myiasis in a female vulvar squamous cell carcinoma caused by Lucilia sericata and Sarcophaga crassipalpis)

    Hiraoka Hiroyuki, Ozawa Toshiyuki, Sowa-Osako Junko, Ichimura Tomoyuki, Kimata-Teramoto Isao, Isozumi Rie, Kaneko Akira, Tsuruta Daisuke

    The Journal of Dermatology   42 ( 8 )   840 - 841   2015.08( ISSN:0385-2407

  • 女性外陰部扁平上皮癌に繰り返し発生したLucilia sericataとSarcophaga crassipalpisによるハエウジ病(Repeated myiasis in a female vulvar squamous cell carcinoma caused by Lucilia sericata and Sarcophaga crassipalpis) Reviewed

    Hiraoka Hiroyuki, Ozawa Toshiyuki, Sowa-Osako Junko, Ichimura Tomoyuki, Kimata-Teramoto Isao, Isozumi Rie, Kaneko Akira, Tsuruta Daisuke

    John Wiley & Sons Australia, Ltd The Journal of Dermatology   42 ( 8 )   840 - 841   2015.08( ISSN:0385-2407

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  • 子宮平滑筋肉腫の新規バイオマーカーについて Reviewed

    市村 友季

    「産婦人科の進歩」編集室 産婦人科の進歩   64 ( 3 )   434 - 434   2012.09( ISSN:0370-8446

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  • 子宮平滑筋肉腫の新規バイオマーカーについて Reviewed

    市村 友季

    「産婦人科の進歩」編集室 産婦人科の進歩   64 ( 3 )   434 - 434   2012.09( ISSN:0370-8446

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  • 子宮平滑筋肉腫の新規バイオマーカーについて

    市村 友季

    産婦人科の進歩   64 ( 3 )   434 - 434   2012.09( ISSN:0370-8446

  • 臨床病理カンファレンス 子宮頸癌 Reviewed

    本田 謙一, 大澤 政彦, 吉田 愛, 市村 友季, 吉田 裕之, 角 俊幸, 西田 典史, 細野 雅子, 若狭 研一, 石河 修, 上田 真喜子

    (株)永井書店 綜合臨床   59 ( 5 )   1315 - 1325   2010.05( ISSN:0371-1900

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  • 臨床病理カンファレンス 子宮頸癌

    本田 謙一, 大澤 政彦, 吉田 愛, 市村 友季, 吉田 裕之, 角 俊幸, 西田 典史, 細野 雅子, 若狭 研一, 石河 修, 上田 真喜子

    綜合臨床   59 ( 5 )   1315 - 1325   2010.05( ISSN:0371-1900

  • Diagnosis of uterine sarcoma in needle biopsy specimens.

    23 ( 1 )   79 - 84   2005

  • Histopathological investigation of uterine myoma, endometrium and myometrium before and after uterine arterial embolization.

    56 ( 9 )   943 - 950   2004

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  • Management of myoma uteri in our department.

    86 ( 3 )   333 - 340   2003

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