Updated on 2026/02/26

写真a

 
NAKATANI Shinya
 
Organization
Graduate School of Medicine Department of Clinical Medical Science Lecturer
School of Medicine Department of Medical Science
Title
Lecturer
Affiliation
Institute of Medcine
Affiliation campus
Abeno Campus

Position

  • Graduate School of Medicine Department of Clinical Medical Science 

    Lecturer  2022.04 - Now

  • School of Medicine Department of Medical Science 

    Lecturer  2022.04 - Now

Degree

  • 糖尿病糸球体のプロテオーム解析 （ Osaka City University ）

Research Areas

  • Life Science / Nephrology

  • Life Science / Nephrology

  • Life Science / Metabolism and endocrinology

Research Interests

  • 腎炎・ネフローゼ症候群

  • 慢性腎臓病

  • 亜鉛

  • ミネラル代謝異常

  • ADPKD

  • T50

  • Zinc

  • ADPKD

Research subject summary

  • VICTORY研究
    エテルカルセチドとマキサカルシトールの血清石灰化傾向におよぼすRCT

    その他
    慢性腎臓病に関わる臨床研究

Professional Memberships

  • 多発性嚢胞腎協会

    2022

  • 日本腎臓病協会

    2022

  • 日本糖尿病学会

    2010

  • 日本臨床腎移植学会

      Domestic

  • 日本透析医学会

      Domestic

  • 日本腎臓学会

      Domestic

  • 日本内科学会

      Domestic

  • 日本透析医学会

  • 日本臨床腎移植学会

  • 日本腎臓学会

  • 日本内科学会

▼display all

Awards

  • 日本腎臓学会西部学術集会優秀演題賞

    2022  

  • 日本腎臓学会西部学術集会　優秀演題賞

    2020.10  

  • CKD-MBD研究会　最優秀演題賞

    2020.04  

  • 日本腎臓学会西部学術集会優秀演題賞

    2020  

  • 日本CKD-MBD研究会 学術集会・総会：最優秀演題賞

    2020  

  • 日本腎臓学会優秀演題賞

    2016  

  • European Dialysis and Transplant Association：Travel Grant Award

    2016  

  • European Dialysis and Transplant Association：Travel Grant Award

    2016  

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    Country：Austria

  • 日本腎臓学会優秀演題賞

    2016  

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    Country：Japan

  • European Dialysis and Transplant Association：Travel Grant Award

    2013  

  • 日本腎臓学会優秀演題賞

    2013  

  • European Dialysis and Transplant Association：Travel Grant Award

    2013  

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    Country：Turkey

  • 日本腎臓学会優秀演題賞

    2013  

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    Country：Japan

  • 日本腎臓学会優秀演題賞

    2012  

  • 日本腎臓学会優秀演題賞

    2012  

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    Country：Japan

  • European Dialysis and Transplant Association：Travel Grant Award

    2011  

  • European Dialysis and Transplant Association：Travel Grant Award

    2011  

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Job Career (off-campus)

  • Osaka Metropolitan University

    2025.07 - Now

  • Osaka Metropolitan University

    2022.04 - 2025.06

  • Osaka City University   Graduate School of Medicine Clinical Medicine Course

    2017.01 - Now

Papers

  • Factors Influencing Resection Time in Endoscopic Submucosal Dissection for Rectal Neuroendocrine Tumors(タイトル和訳中)

    Nakatani Shinya, Hayasaka Junnosuke, Ishii Tsuyoshi, Oda Minoru, Kawai Yusuke, Yamato Hiroshi, Ochiai Yorinari, Suzuki Yugo, Mitsunaga Yutaka, Odagiri Hiroyuki, Matsui Akira, Miura Yasuro, Hoteya Shu

    DEN Open   6 ( 1 )   deo2.70199 - deo2.70199   2026.04

  • Vedolizumab Induces Remission in Two Cases of Ulcerative Colitis With Upper Gastrointestinal Involvement(タイトル和訳中)

    Nakatani Shinya, Yamazaki Yuta, Higuchi Kensuke, Otoyama Yumi, Suzuki Norihiro, Kikuchi Kazuo, Fujiwara Takahisa, Katagiri Atsushi, Ohara Jyun, Yoshida Hitoshi

    DEN Open   6 ( 1 )   deo2.70205 - deo2.70205   2026.04

  • An autopsy-proven case of normotensive scleroderma renal crisis with refractory pleuroperitoneal effusion.

    Uedono H, Mori K, Nakatani S, Watanabe K, Furuya M, Morioka F, Sone K, Miki Y, Tsuda A, Tanaka S, Morioka T, Kohashi K, Emoto M

    CEN case reports   15 ( 2 )   52   2026.02

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  • Measuring electrooculograms of a simulated underwater diver by utilizing conductivity of seawater.

    Saiki T, Araki N, Nakatani S, Sobajima H, Okuno R, Arima M

    Scientific reports   16 ( 1 )   5706   2026.01

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  • Inverse Association between T50 Calciprotein Crystallization (Serum Calcification Propensity) and Carotid Artery Intima-Media Thickness in Health Examinees with a Reduced Kidney Function

    Nagakura Yu, Shoji Tetsuo, Fukumoto Shinya, Uedono Hideki, Nakatani Shinya, Mori Katsuhito, Nagata Yuki, Imanishi Yasuo, Morioka Tomoaki, Watanabe Toshio, Emoto Masanori

    Journal of Atherosclerosis and Thrombosis   advpub ( 0 )   2026.01（ ISSN:1340-3478 ） （ eISSN:18803873 ）

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    <p> <b>Aim:</b> T50 is the time required for primary calciprotein particles (CPPs) to transform into secondary CPPs <i>in vitro</i>, reflecting serum calcification propensity, and used as a biomarker for calcification stress. Since secondary CPPs induce inflammation and oxidative stress, they may promote atherosclerosis. We investigated whether or not T50 was associated with carotid artery intima-media thickness (IMT).</p><p><b>Methods:</b> This was a cross-sectional study of 202 health examinees. T50 was measured by the established nephelometric method. Carotid artery IMT was measured by high-resolution ultrasonography. The association between T50 and IMT was evaluated by a multivariable-adjusted linear regression analysis.</p><p><b>Results:</b> In a univariate analysis, IMT was not significantly correlated with T50. A multivariable-adjusted linear regression analysis showed that IMT was independently associated with age, sex, diabetes mellitus, dyslipidemia, and fetuin-A but not with T50 in the total subjects. However, when stratified by the estimated glomerular filtration rate (eGFR), T50 was independently and inversely associated with IMT in the subgroup with an eGFR ＜60 mL/min/1.73 m<sup>2</sup> (β = −0.418, P = 0.013), whereas it was not in the subgroup with an eGFR ≥ 60 mL/min/1.73 m<sup>2</sup>.</p><p><b>Conclusion:</b> T50 was independently and inversely associated with IMT in health examinees with a reduced kidney function, suggesting a novel link between calcification stress and atherosclerosis, particularly in those with chronic kidney disease.</p>

    DOI： 10.5551/jat.65964

    PubMed

    CiNii Research

  • Correction: Estimated T50 calciprotein crystallization test in patients undergoing hemodialysis: Osaka Dialysis Complication Study (ODCS).

    Tetsuo Shoji, Daijiro Kabata, Yu Nagakura, Shinya Nakatani, Hideki Uedono, Yuki Nagata, Hisako Fujii, Katsuhito Mori, Yasuo Imanishi, Tomoaki Morioka, Masanori Emoto

    Clinical and experimental nephrology   30 ( 1 )   180 - 182   2026.01（ ISSN:1342-1751 ）

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    International / domestic magazine：Domestic journal  

    DOI： 10.1007/s10157-025-02756-y

    PubMed

  • Longitudinal change in thigh muscle cross-sectional area in association with hospitalization among patients undergoing hemodialysis: the Osaka Dialysis Complication Study (ODCS).

    Matsufuji S, Shoji T, Lee S, Tsujimoto Y, Nakatani S, Morioka T, Mori K, Emoto M

    Clinical and experimental nephrology   2025.12（ ISSN:1342-1751 ）

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  • Estimated T50 calciprotein crystallization test in patients undergoing hemodialysis: Osaka Dialysis Complication Study (ODCS).

    Tetsuo Shoji, Daijiro Kabata, Yu Nagakura, Shinya Nakatani, Hideki Uedono, Yuki Nagata, Hisako Fujii, Katsuhito Mori, Yasuo Imanishi, Tomoaki Morioka, Masanori Emoto

    Clinical and experimental nephrology   29 ( 12 )   1850 - 1862   2025.12（ ISSN:1342-1751 ）

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    Publishing type：Research paper (scientific journal)   International / domestic magazine：Domestic journal  

    BACKGROUND: T50 calciprotein crystallization test (serum calcification propensity, T50) is a blood test which assesses the resistance of the serum to calcification stress in vitro. Because of its limited availability in clinical practice of chronic kidney disease, we aimed to develop equations for estimated T50 (eT50). METHODS: This was an observational study in 1,651 hemodialysis patients whose T50 was measured by the method Pasch et al. The data sets were divided into two groups for the derivation (N = 1,003) and validation (N = 648) of the equations. Logarithmically transformed values of measured T50 were regressed by relevant variables selected from 36 candidates based on the Akaike's Information Criteria. RESULTS: Because the initial model A included 19 variables, we developed simpler models B and C with 10 and 5 variables, respectively, for clinical use. All these models included serum phosphate, magnesium, sodium, chloride, and total ion binding capacity. When these equations were validated, the intercept, slope, and R2 values were 1.130, 0.770, 0.596 for model A, 1.093, 0.782, and 0.597 for model B, and 0.979, 0.806, and 0.573 for model C, respectively. Multivariable-adjusted Fine-Gray analysis showed that a lower eT50 value by model A, B, or model C was an independent predictor of a higher risk of new cardiovascular events in the total cohort as the measured T50 was. CONCLUSIONS: We developed three equations for eT50 from clinically available variables. These eT50 values may be useful if measured T50 is not available.

    DOI： 10.1007/s10157-025-02735-3

    PubMed

  • Estimated T50 calciprotein crystallization test in patients undergoing hemodialysis: Osaka Dialysis Complication Study(ODCS)(タイトル和訳中)

    Shoji Tetsuo, Kabata Daijiro, Nagakura Yu, Nakatani Shinya, Uedono Hideki, Nagata Yuki, Fujii Hisako, Mori Katsuhito, Imanishi Yasuo, Morioka Tomoaki, Emoto Masanori

    Clinical and Experimental Nephrology   29 ( 12 )   1850 - 1862   2025.12（ ISSN:1342-1751 ）

  • ソラフェニブ6年投与後にAKI発症にて透析導入となった腎癌肺転移の1例

    藤田 晃輝, 町田 裕一, 喜多 浩士, 松井 七海, 関戸 美真, 増田 一輝, 壁井 和也, 岩井 友明, 鞍作 克之, 内田 潤次, 仲谷 慎也

    泌尿器科紀要   71 ( 10 )   366 - 366   2025.10（ ISSN:0018-1994 ）

  • Association Between Body Mass Index and Age at End-Stage Renal Disease in Patients With Autosomal Dominant Polycystic Kidney Disease in the United States and Japan.

    Tatsuya Suwabe, Vicente E Torres, Lisa E Vaughan, Chuck D Madsen, Peter C Harris, Yosuke Shimada, Shinya Nakatani, Junichi Hoshino, Saori Nishio, Toshio Mochizuki, Eiichiro Kanda, Norio Hanafusa, Masanori Abe, Satoru Muto

    Mayo Clinic proceedings   100 ( 9 )   1535 - 1550   2025.09（ ISSN:0025-6196 ）

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    Publishing type：Research paper (scientific journal)   International / domestic magazine：International journal  

    OBJECTIVE: To evaluate the association between body mass index (BMI) and age at initiation of renal replacement therapy (RRT) of patients with autosomal dominant polycystic kidney disease (ADPKD) in the United States and Japan, 2 populations with different dietary habits and BMIs. METHODS: We performed a cross-sectional analysis using data from the United States Renal Data System (USRDS) and the Japanese Society for Dialysis Therapy Renal Data Registry (JRDR) to compare age, BMI, and other clinical characteristics of the patients who initiated RRT in the 2 countries between January 1, 2006, and December 31, 2007. RESULTS: This study included 3556 patients (1877 men and 1679 women) with RRT from the USRDS (n=2491) and JRDR (n=1065). Mean ages at RRT were 56.6±13.1 years in the United States and 61.6±12.5 years in Japan (P<.001). The BMI was 28.2±7.1 kg/m2 in the USRDS and 22.0±3.3 kg/m2 in the JRDR (P<.001). Japanese participants were the oldest, followed in descending order by Asian Americans, White Americans, and African Americans. Japanese participants had the lowest BMI, followed in ascending order by Asian Americans, White Americans, and African Americans. Univariable and adjusted analyses found that BMI was significantly and inversely associated with age at RRT, both overall and separately in American and Japanese populations. CONCLUSION: Lower BMI is significantly associated with older age at RRT in patients with ADPKD in both the United States and Japan. Japanese individuals had lower BMI and were older than US people of various ethnicities. Lower BMI in Japan is likely to be associated with a slower progression of ADPKD.

    DOI： 10.1016/j.mayocp.2024.12.019

    PubMed

  • Lupus podocytopathy as a first renal manifestation in long-standing systemic lupus erythematosus: a case report.

    Togashi T, Fujisawa Y, Yano Y, Ishihara R, Katsushima M, Fukumoto K, Watanabe R, Nakatani S, Yamada S, Kohashi K, Emoto M, Hashimoto M

    Modern rheumatology case reports   9 ( 2 )   2025.07

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  • Zinc Deficiency in Chronic Kidney Disease and Hemodialysis: Insights from Basic Research to Clinical Implications.

    Shinya Nakatani, Tomoaki Morioka, Fumiyuki Morioka, Katsuhito Mori, Masanori Emoto

    Nutrients   17 ( 13 )   2025.06

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    Publishing type：Research paper (scientific journal)   International / domestic magazine：International journal  

    Zinc is an essential trace element involved in diverse physiological processes in humans. Zinc deficiency is common in patients with chronic kidney disease (CKD), including those undergoing hemodialysis. This narrative review synthesizes both experimental and clinical findings on zinc status in CKD patients. Literature was primarily retrieved from PubMed using the keywords "zinc" AND ("CKD" OR "hemodialysis") AND at least one of the following: "cardiovascular disease (CVD)", "vascular calcification", "anemia", "blood pressure", OR "infection". In vitro, studies have shown that zinc suppressed phosphate-induced vascular calcification while zinc deficiency directly promoted calcification. Clinically, serum zinc levels were positively correlated with calcification propensity in patients with CKD. In vivo zinc deficiency has been implicated in elevated blood pressure, Moreover, zinc supplementation enhanced erythropoiesis and improved responsiveness to erythropoiesis-stimulating agents in both animal models and humans. We recently reported that low serum zinc levels are associated with increased mortality in hemodialysis patients with hypoalbuminemia. Previous randomized controlled trials (RCTs) suggest a daily dose of approximately 45 mg of zinc for 2 months mitigates inflammation, oxidative stress, and malnutrition in patients undergoing hemodialysis. Emerging evidence suggests that vascular calcification, hypertension, and renal anemia are newly recognized features of zinc deficiency and are established risk factors for CKD progression, CVD, and mortality. However, the impact of zinc supplementation on these clinical outcomes remains inconclusive. Further RCTs are required to establish zinc supplementation as an effective therapeutic strategy for improving various outcomes in patients with CKD including hemodialysis.

    DOI： 10.3390/nu17132191

    PubMed

  • T50 Calciprotein Crystallization and the Decreased Role of Fetuin-A in Type 2 Diabetes

    Nagakura Yu, Shoji Tetsuo, Fukumoto Shinya, Uedono Hideki, Nakatani Shinya, Mori Katsuhito, Nagata Yuki, Imanishi Yasuo, Morioka Tomoaki, Watanabe Toshio, Emoto Masanori

    Journal of Atherosclerosis and Thrombosis   32 ( 6 )   763 - 774   2025.06（ ISSN:1340-3478 ） （ eISSN:18803873 ）

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    Publishing type：Research paper (scientific journal)   International / domestic magazine：Domestic journal  

    <p> <b>Aim:</b> Patients with type 2 diabetes mellitus (T2D) are prone to develop vascular calcification. Fetuin-A protects against vascular calcification but it increases insulin resistance. T50 calciprotein crystallization (also called serum calcification propensity) is a novel marker of calcification stress. This study examined whether T2D affects T50 and the potential role of fetuin-A in the relationship between T2D and T50.</p><p><b>Methods:</b> This cross-sectional study included 101 individuals with T2D and 101 individuals without diabetes (controls). T50 and fetuin-A levels were measured using the established nephelometric method and an enzyme-linked immunosorbent assay, respectively.</p><p><b>Results:</b> Although fetuin-A levels were higher in the T2D group, T50 was not significantly different between the T2D and control groups. In multivariable-adjusted analyses of the total population, T50 was not independently associated with the presence of T2D, fasting plasma glucose, or HbA1c, whereas T50 was significantly associated with fetuin-A, phosphate, and calcium levels. The association between T50 and fetuin-A was modified by the presence of T2D. A subgroup analysis revealed that the positive association between T50 and fetuin-A was significant but smaller in the T2D group, and that the associations of T50 with serum phosphate and calcium were more evident in the T2D group. Additional analyses showed that T50/fetuin-A ratio was lower in the T2D group and that T50/fetuin-A ratio was inversely correlated with fasting glucose and HbA1c levels.</p><p><b>Conclusions:</b> T2D itself was not significantly associated with T50 but T2D modified the association between T50 and fetuin-A in favor of developing vascular calcification in T2D.</p>

    DOI： 10.5551/jat.65351

    PubMed

    CiNii Research

  • 2型糖尿病におけるT50 calciprotein crystallizationとfetuin-Aの役割の低下(T50 Calciprotein Crystallization and the Decreased Role of Fetuin-A in Type 2 Diabetes)

    Nagakura Yu, Shoji Tetsuo, Fukumoto Shinya, Uedono Hideki, Nakatani Shinya, Mori Katsuhito, Nagata Yuki, Imanishi Yasuo, Morioka Tomoaki, Watanabe Toshio, Emoto Masanori

    Journal of Atherosclerosis and Thrombosis   32 ( 6 )   763 - 774   2025.06（ ISSN:1340-3478 ）

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    2型糖尿病(T2D)がT50(血清石灰化傾向)へ及ぼす影響ならびにT2DとT50の関連におけるfetuin-Aの潜在的役割について、T2D群101例および非糖尿病群(対照群)101例を対象に検討した。fetuin-A濃度はT2D群で有意に高値であったが、T50については両群間で有意差はなかった。全例の解析において、T50はT2D、空腹時血漿ブドウ糖、HbA1c値とは関連しなかったが、血清中のfetuin-A濃度、リン濃度、カルシウム濃度と有意な関連を示した。T50とfetuin-A濃度の関連にT2Dによる効果修飾が認められた。各群の解析では、両群ともにT50とfetuin-Aは有意な正の関連を示したが、それらの関連はT2D群で弱かった。一方、T50とリン濃度およびカルシウム濃度の関連はT2D群でのみ有意であった。T50/fetuin-A比は対照群に比べT2D群で低値であり、空腹時血糖値およびHbA1c値と負の相関を示した。

  • 大腸内視鏡的粘膜下層剥離術において内視鏡モニター上方の病変は独立した困難因子である　後ろ向き研究(Upward lesion orientation on an endoscopic monitor is an independent factor affecting difficulty of colorectal endoscopic submucosal dissection: a retrospective study)

    Yamazaki Yuta, Katagiri Atsushi, Mori Daichi, Onishi Yoshinao, Higuchi Kensuke, Suzuki Norihiro, Kikuchi Kazuo, Nakatani Shinya, Inoki Kazuya, Konda Kenichi, Tojo Masayuki, Yamamura Fuyuhiko, Yoshida Hitoshi

    The Showa Medical University Journal   37 ( 2 )   71 - 81   2025.06

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    大腸内視鏡的粘膜下層剥離術(ESD)の難易度と内視鏡モニター上の病変位置との関係を調べた。本研究は単施設後ろ向き研究であり、2019年1月～2024年8月に当院でESDを施行した大腸腫瘍患者375例406病変(平均70.4±11.0歳)を対象とした。120分以上の手技時間を要したESDを困難例と定義し、困難因子および不完全切除因子を解析した。その結果、腫瘍径≧40mm、内視鏡モニター上方に位置する病変、粘膜下の線維化が有意な困難因子として検出された。粘膜下線維化、粘膜下層深部浸潤、大腸ESD経験症例数20例未満が独立した病変一括切除困難因子であったが、腫瘍径、内視鏡モニター上の病変位置は有意な因子ではなかった。内視鏡モニター上方に位置する病変に対する大腸ESDは、困難例として術者や治療戦略を決定する必要があると考えられた。

  • Kidney Function Trajectories with Tolvaptan in ADPKD Patients with CKD-G5.

    Akinari Sekine, Junichi Hoshino, Toshio Mochizuki, Shinya Nakatani, Saori Nishio, Tatsuya Suwabe, Hiroki Hayashi, Hirayasu Kai, Koichi Seta, Fumihiko Hattanda, Sumi Hidaka, Kazushige Hanaoka, Mahiro Kurashige, Hiroshi Kataoka, Kiyotaka Uchiyama, Keiji Shimazu, Eiji Ishikawa, Yosuke Shimada, Haruna Kawano, Ken Tsuchiya, Shigeo Horie, Ichiei Narita, Yoshitaka Isaka, Satoru Muto

    Kidney international reports   10 ( 6 )   1864 - 1873   2025.06（ ISSN:24680249 ）

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    Publishing type：Research paper (scientific journal)   International / domestic magazine：International journal  

    INTRODUCTION: Improvement of estimated glomerular filtration rate (eGFR) slope has been established using tolvaptan in patients with Autosomal Dominant Polycystic Kidney Disease (ADPKD). In Japan, the therapeutic dose of tolvaptan (60-120 mg/d) must be discontinued at chronic kidney disease stage G5 (CKD-G5), eGFR < 15 ml/min per 1.73 m2. However, low-dose tolvaptan (≤ 15 mg/d) can be continued in CKD-G5 patients with heart failure complicated by kidney failure. METHODS: This was a Japanese nation-wide, multicenter, retrospective observational study. Between May 2014 and September 2019, 110 patients with ADPKD developed CKD-G5 were included (data: previous 10 years). Participants were categorized into 3 groups: the tolvaptan continued group (received tolvaptan before CKD-G5 and reduced the dose to ≤ 15 mg at CKD-G5, N = 14), the tolvaptan discontinued group (received tolvaptan before CKD-G5 but discontinued at CKD-G5, N = 13), and the non-tolvaptan group (never received tolvaptan, N = 83). RESULTS: The eGFR slope remained stable before and during CKD-G5 in the non-tolvaptan group. In the tolvaptan discontinued group, the eGFR slope was accelerated from before (-3.3 [-4.3, -2.5] ml/min per 1.73 m2/yr) to during CKD-G5 (-5.3 [-6.7, -3.8]). However, in the tolvaptan continued group, the eGFR slope did not change from before (-3.9 [-5.4, -2.6]) to during CKD-G5 (-3.8 [-5.4, -3.4]). Compared with the tolvaptan continued group, the eGFR slope worsened significantly from before to during CKD-G5 in the tolvaptan discontinued group (P = .006). CONCLUSION: Continuation of low-dose tolvaptan may be effective in suppressing kidney function deterioration in ADPKD patients with CKD-G5. A clinical trial is needed to evaluate its efficacy and safety.

    DOI： 10.1016/j.ekir.2025.03.020

    PubMed

  • 特集 CKD-MBD -進歩と革新 CKD-MBD関連因子 血清石灰化傾向(T50)

    上殿 英記, 仲谷 慎也, 庄司 哲雄

    腎と透析   98 ( 5 )   583 - 588   2025.05（ ISSN:03852156 ）

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  • 【CKD-MBD -進歩と革新】CKD-MBD関連因子　血清石灰化傾向(T50)

    上殿 英記, 仲谷 慎也, 庄司 哲雄

    腎と透析   98 ( 5 )   583 - 588   2025.05（ ISSN:0385-2156 ）

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    ＜文献概要＞はじめに　血管石灰化は慢性腎臓病(chronic kidney disease:CKD)患者に高頻度に認められ,予後悪化と関連する。この血管石灰化の進展には多くの因子が関与するが,リンがその中心的な役割を果たしているとされてきた。一方,肝で分泌される多機能糖蛋白質であるfetuin-Aは,石灰化抑制作用を有する。体内でリン・カルシウムの負荷がかかると,fetuin-Aはリン酸カルシウム結晶の析出を防ぐため,コロイド状のprimary CPP(calciprotein particles)を形成する。つまり,CPPは石灰化抑制作用の結果として生じた産物であると考えられるが,過剰な石灰化ストレスがかかると,ハイドロキシアパタイトへの結晶化が進み,secondary CPPへと成熟する。近年の研究から,このsecondary CPPが血管石灰化におけるリン毒性の主な実体であることが示されている。そのため,primary CPPからsecondary CPPへの成熟を抑制することが,石灰化の進行を防ぐのに重要であると考えられる。このprimary CPPからsecondary CPPへの変換を示す指標として,「血清石灰化傾向(T50)」が注目を集めており,T50をサロゲートマーカーとしたさまざまな臨床研究が行われている。本稿では,新たなリン毒性・石灰化ストレスの指標であるT50について概説する。

  • Infrared bubble recognition in the Milky Way and beyond using deep learning

    Nishimoto S.

    Publications of the Astronomical Society of Japan   77 ( 2 )   403 - 424   2025.04（ ISSN:00046264 ）

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  • Definition of hyperfiltration taking into account age-related decline in renal function in kidney donor candidates with obesity and glucose tolerance disorder.

    Akihiro Tsuda, Katsuhito Mori, Hideki Uedono, Shinya Nakatani, Yuki Nagata, Masafumi Kurajoh, Shinsuke Yamada, Tomoaki Morioka, Eiji Ishimura, Junji Uchida, Masanori Emoto

    Hypertension research : official journal of the Japanese Society of Hypertension   48 ( 3 )   1115 - 1124   2025.03（ ISSN:0916-9636 ）

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    Publishing type：Research paper (scientific journal)   International / domestic magazine：International journal  

    The definition of hyperfiltration, the main pathogenesis in renal impairment in obesity and diabetes mellitus, is uncertain. Glomerular filtration rate (GFR) declines physiologically with aging, and there is inaccuracy in GFR in obesity due to body surface area (BSA) correction. Here, we defined hyperfiltration using GFR without BSA correction, but with inclusion of aging, and investigated hyperfiltration using this definition and absolute GFR > 125 mL/min. The subjects were 180 kidney donor candidates (56.4 ± 11.3 years old, 79 males). GFR was evaluated using inulin clearance. A two-hour 75-g oral glucose tolerance test was also performed. The subjects were divided into four groups with and without a combination of glucose tolerance disorder and BMI. Normal glucose tolerance (NGT) and BMI < 25 kg/m2 were defined as normal, and hyperfiltration was defined as the upper 95% confidence interval of the relationship of aging and GFR in normal cases, and compared with GFR > 125 mL/min. RESULTS: GFR without BSA correction and UAE in non-NGT subjects with obesity were higher than in other groups, but GFR with BSA correction did not show this relationship. In multiple regression analysis, BMI was independently associated with GFR without BSA correction, but not with BSA correction. Aging was consistently associated with GFR. The prevalence of hyperfiltration by our definition (GFR = -0.883 × Age + 167.398) was significantly higher than that using GFR > 125 mL/min (P < 0.0001). Hyperfiltration in obesity and/or glucose tolerance disorder should be evaluated using GFR without BSA correction and including the decline of GFR due to aging.

    DOI： 10.1038/s41440-024-02020-y

    PubMed

  • 胃内視鏡的粘膜下層剥離術におけるレスキュースコープとしてのマルチベンディングスコープの使用　後ろ向き研究(Use of a multibending scope as a rescue scope in gastric endoscopic submucosal dissection: A retrospective study)

    Onishi Yoshinao, Katagiri Atsushi, Mori Daichi, Yamazaki Yuta, Higuchi Kensuke, Suzuki Norihiro, Kikuchi Kazuo, Nakatani Shinya, Gocho Toshihiko, Inoki Kazuya, Konda Kenichi, Tojo Masayuki, Yamamura Fuyuhiko, Yoshida Hitoshi

    The Showa Medical University Journal   37 ( 1 )   2 - 10   2025.03

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    胃腫瘍に対する内視鏡的粘膜下層剥離術(ESD)におけるレスキュースコープとしてのマルチベンディングスコープ(MBS)の使用に関連する要因を調査した。本研究は単施設後ろ向き研究であり、2015年1月～2023年6月に当院で胃腫瘍に対してESDを施行した502例を対象とした。このうち、MBSをレスキュースコープとして使用した患者81例をMB群、従来のスコープのみでESDを施行した患者421例をC群とし、両群を比較した。その結果、MB群はC群に比べて処置時間が120分以上の症例(29.6% vs. 10.7%)およびESDが困難であった症例(32.1% vs. 10.9%)の割合が有意に高かった。さらに、MB群はC群に比べて小彎病変(67.9% vs. 38.2%)、20mm以上の病変(59.3% vs. 38.0%)、胃の上部3分の2の病変(80.2% vs. 63.4%)、内視鏡的潰瘍併存病変(8.6% vs. 3.1%)で頻度が有意に高かった。これらの因子は、多変量解析による調整後も有意であった。

  • 肥満および耐糖能障害を有する腎移植ドナー候補者における加齢による腎機能低下を考慮した過剰濾過の定義(Definition of hyperfiltration taking into account age-related decline in renal function in kidney donor candidates with obesity and glucose tolerance disorder)

    Tsuda Akihiro, Mori Katsuhito, Uedono Hideki, Nakatani Shinya, Nagata Yuki, Kurajoh Masafumi, Yamada Shinsuke, Morioka Tomoaki, Ishimura Eiji, Uchida Junji, Emoto Masanori

    Hypertension Research   48 ( 3 )   1115 - 1124   2025.03（ ISSN:0916-9636 ）

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    糸球体濾過量(GFR)から過剰濾過を判定する閾値について検討した。腎移植ドナー候補者180名を耐糖能異常と肥満の有無で4群に分け、実測GFR、尿アルブミン排泄量(UAE)を比較した。耐糖能異常の肥満群は、体表面積(BSA)未補正GFRとUAEが他群より高く、過剰濾過の存在が示唆されたが、BSA補正GFRには差がなかった。3通りの重回帰モデルにおいて、年齢はBSA未補正および補正後のGFRと関連したが、BMIはBSA未補正GFRとのみ関連を示した。耐糖能正常の非肥満群における年齢とBSA未補正GFRとの関係の95%信頼区間上限値を過剰濾過の閾値と定義し、その計算式を導出した。既報の閾値(実測GFR>125mL/min)で過剰濾過に該当せず、本式で過剰濾過とされた患者(2名)はいずれも高齢であった。肥満者や耐糖能異常患者の過剰濾過の評価はBSA未補正GFRで行い、加齢によるGFR低下を考慮する必要があると考えられた。

  • CKD診療ガイド2024

    丸山 彰一, 神田 英一郎, 久米 真司, 猪阪 善隆, 石倉 健司, 臼井 丈一, 内田 啓子, 岡田 浩一, 今田 恒夫, 斎藤 知栄, 鈴木 仁, 田中 哲洋, 坪井 直毅, 中川 直樹, 西尾 妙織, 深水 圭, 本田 浩一, 升谷 耕介, 横山 啓太郎, 和田 淳, 和田 隆志, 和田 健彦, 淺沼 克彦, 旭 浩一, 阿部 雅紀, 石本 卓嗣, 川浪 大治, 駒場 大峰, 佐田 憲映, 祖父江 理, 仲谷 慎也, 中司 敦子, 日比野 聡, 藤井 秀毅, 星野 純一, 細島 康宏, 前嶋 明人, 丸山 之雄, 森山 能仁, 安田 日出夫, 安田 宜成, 山本 卓, 小杉 智規, 日本腎臓学会, CKD診療ガイドライン改訂委員会

    日本腎臓学会誌   67 ( 1 )   3 - 177   2025.01（ ISSN:0385-2385 ）

  • The Surprise Question in Hemodialysis, Frailty, Nutrition, Patient-reported Quality of Life, and All-Cause Mortality: The Osaka Dialysis Complication Study (ODCS).

    Tetsuo Shoji, Daijiro Kabata, Seiichi Kimura, Yuki Nagata, Katsuhito Mori, Shinya Nakatani, Hisako Fujii, Tomoaki Morioka, Masanori Emoto

    Kidney medicine   6 ( 12 )   100914 - 100914   2024.12

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    Publishing type：Research paper (scientific journal)   International / domestic magazine：International journal  

    RATIONALE & OBJECTIVE: A response "no" (SQ-No) to the surprise question (SQ) of whether a clinician would be surprised if a dialysis patient died in the next 6 months is associated with a higher risk of all-cause death. It is uncertain what domains are intuitively assessed with the SQ. We hypothesized that the SQ would assess the patient's frailty, malnutrition, or patient-perceived health-related quality of life in a cohort of patients on maintenance hemodialysis. STUDY DESIGN: Cohort study. SETTING & PARTICIPANTS: A multicenter study including 994 patients on maintenance hemodialysis in Japan. PREDICTORS: (1) SQ answered by nurses; (2) frailty by modified Cardiovascular Health Study criteria; (3) malnutrition as evaluated by Geriatric Nutritional Risk Index (GNRI); and (4) patient-perceived health-related quality of life examined by the 36-Item Short Form Health Survey (SF-36) physical component summary (PCS). OUTCOMES: All-cause mortality. ANALYTICAL APPROACH: Cox proportional hazard models. RESULTS: Median age and dialysis vintage were 66 and 5.9 years, respectively, 35.8% were women, and 39.6% had diabetic kidney disease. The prevalence of SQ-No and frailty was 19.7% and 45.9%. Median GNRI and SF-36 PCS scores were 96.3 and 36.9, respectively. During the 5-year follow-up, 247 patients died. SQ-No, being frail, low GNRI, and low SF-36 PCS were each significant predictors of a higher risk for mortality independent of potential confounders. SQ-No remained a significant predictor after further adjustment for frailty or GNRI, but SQ-No was no longer significant when adjusted for SF-36 PCS. LIMITATIONS: We did not assess the agreement of responses to the SQ between different raters. CONCLUSIONS: The predictive ability of the SQ was closely related to SF-36 PCS in hemodialysis patients. Nurses' answer to the SQ appears to assess the physical domain of patient-perceived health-related quality of life rather than objectively assessed frailty or malnutrition.

    DOI： 10.1016/j.xkme.2024.100914

    PubMed

  • Associations of Cognitive Function with Serum Magnesium and Phosphate in Hemodialysis Patients: A Cross-Sectional Analysis of the Osaka Dialysis Complication Study (ODCS).

    Tetsuo Shoji, Katsuhito Mori, Yu Nagakura, Daijiro Kabata, Kaori Kuriu, Shinya Nakatani, Hideki Uedono, Yuki Nagata, Hisako Fujii, Yasuo Imanishi, Tomoaki Morioka, Masanori Emoto

    Nutrients   16 ( 21 )   2024.11

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    Publishing type：Research paper (scientific journal)   International / domestic magazine：International journal  

    Cognitive impairment and dementia are common in patients with chronic kidney disease, including those undergoing hemodialysis. Since magnesium and phosphate play important roles in brain function and aging, alterations in these and other factors related to bone mineral disorder (MBD) may contribute to low cognitive performance in patients on hemodialysis. This cross-sectional study examined the associations between cognitive function and MBD-related factors among 1207 patients on maintenance hemodialysis. Cognitive function was assessed by the Modified Mini-Mental State examination (3MS). The exposure variables of interest were serum magnesium, phosphate, calcium, calcium-phosphate product, intact parathyroid hormone, fetuin-A, T50 calciprotein crystallization test, use of phosphate binders, use of cinacalcet, and use of vitamin D receptor activators. Multivariable-adjusted linear regression models were used to examine the associations between 3MS and each of the exposure variables independent of 13 potential non-mineral confounders. We found that lower 3MS was associated with lower serum magnesium, lower phosphate, lower calcium-phosphate product, and nonuse of phosphate binders. These results suggest that magnesium and phosphate play potentially protective roles against cognitive impairment in this population.

    DOI： 10.3390/nu16213776

    PubMed

  • Protocol for the nationwide registry of patients with polycystic kidney disease: japanese national registry of PKD (JRP).

    Shinya Nakatani, Haruna Kawano, Mai Sato, Junichi Hoshino, Saori Nishio, Kenichiro Miura, Akinari Sekine, Tatsuya Suwabe, Sumi Hidaka, Hiroshi Kataoka, Eiji Ishikawa, Keiji Shimazu, Kiyotaka Uchiyama, Takuya Fujimaru, Tomofumi Moriyama, Mahiro Kurashige, Wataru Shimabukuro, Fumihiko Hattanda, Tomoki Kimura, Yusuke Ushio, Shun Manabe, Hirofumi Watanabe, Michihiro Mitobe, Koichi Seta, Yosuke Shimada, Hirayasu Kai, Kan Katayama, Daisuke Ichikawa, Hiroki Hayashi, Kazushige Hanaoka, Toshio Mochizuki, Koichi Nakanishi, Ken Tsuchiya, Shigeo Horie, Yoshitaka Isaka, Satoru Muto

    Clinical and experimental nephrology   28 ( 10 )   1004 - 1015   2024.10（ ISSN:1342-1751 ）

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    Publishing type：Research paper (scientific journal)   International / domestic magazine：Domestic journal  

    BACKGROUND: Autosomal dominant polycystic kidney disease (ADPKD) and autosomal recessive polycystic kidney disease (ARPKD) are major genetic polycystic kidney diseases that can progress to end-stage kidney disease (ESKD). Longitudinal data on the clinical characteristics associated with clinical outcomes in polycystic kidney disease (PKD), including the development of ESKD and cardiovascular disease (CVD) are lacking in Japan. To address this unmet need the authors are establishing a novel, web-based, Nationwide Cohort Registry Study-the Japanese Registry of PKD (JRP). METHODS: The JRP is a prospective cohort study for ADPKD (aim to recruit n = 1000 patients), and both a retrospective and prospective study for ARPKD (aim to recruit n = 100). In the prospective registry, patients will be followed-up for 10 years every 6 months and 12 months for patients with ADPKD and ARPKD, respectively. Data collection will be recorded on Research Electronic Data Capture (REDCap) starting on April 1, 2024, with recruitment ending on March 31, 2029. (jRCT 1030230618). RESULTS: Data to be collected include: baseline data, demographics, diagnostic and genetic information, radiological and laboratory findings, and therapeutic interventions. During follow-up, clinical events such as development of ESKD, hospitalization, occurrence of extra kidney complications including CVD events, and death will be recorded, as well as patient-reported health-related quality of life for patients with ADPKD. CONCLUSIONS: The JRP is the first nationwide registry study for patients with ADPKD and ARPKD in Japan, providing researchers with opportunities to advance knowledge and treatments for ADPKD and ARPKD, and to inform disease management and future clinical practice.

    DOI： 10.1007/s10157-024-02509-3

    PubMed

  • 維持血液透析患者における亜鉛欠乏と総死亡との関連

    森岡 史行, 仲谷 慎也, 庄司 哲雄, 上田 真優子, 吉田 寿子, 森岡 与明, 森 克仁, 繪本 正憲

    マグネシウム   43 ( 1 )   80 - 81   2024.10（ ISSN:0913-4867 ）

  • 多発性嚢胞腎患者に関する全国登録プロトコール　日本PKD全国登録(JRP)(Protocol for the nationwide registry of patients with polycystic kidney disease: japanese national registry of PKD(JRP))

    Nakatani Shinya, Kawano Haruna, Sato Mai, Hoshino Junichi, Nishio Saori, Miura Kenichiro, Sekine Akinari, Suwabe Tatsuya, Hidaka Sumi, Kataoka Hiroshi, Ishikawa Eiji, Shimazu Keiji, Uchiyama Kiyotaka, Fujimaru Takuya, Moriyama Tomofumi, Kurashige Mahiro, Shimabukuro Wataru, Hattanda Fumihiko, Kimura Tomoki, Ushio Yusuke, Manabe Shun, Watanabe Hirofumi, Mitobe Michihiro, Seta Koichi, Shimada Yosuke, Kai Hirayasu, Katayama Kan, Ichikawa Daisuke, Hayashi Hiroki, Hanaoka Kazushige, Mochizuki Toshio, Nakanishi Koichi, Tsuchiya Ken, Horie Shigeo, Isaka Yoshitaka, Muto Satoru, The JRP collaborators

    Clinical and Experimental Nephrology   28 ( 10 )   1004 - 1015   2024.10（ ISSN:1342-1751 ）

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    日本における多発性嚢胞腎(PKD)のアンメットニーズに対応するため、ウェブベースの新しい全国コホート登録研究である日本PKD登録(JRP)を設立した。JRPでは、常染色体優性多発性嚢胞腎(ADPKD)については前向きコホート研究(患者1000例を登録することを目標)であり、常染色体劣性多発性嚢胞腎(ARPKD)については後ろ向き研究および前向き研究(患者100例を登録することを目標)である。前向き登録では、ADPKD患者は6ヵ月ごと、ARPKD患者は12ヵ月ごとに10年間追跡調査を行う。データ収集は2024年4月1日からResearch Electronic Data Capture(REDCap)に記録され、募集は2029年3月31日に終了する。収集されるデータには、ベースラインデータ、人口統計、診断および遺伝学的情報、放射線学的および検査所見、治療介入が含まれる。追跡期間中、末期腎不全の発症、入院、心血管疾患イベントを含む腎外合併症の発生、死亡などの臨床イベント、およびADPKD患者の患者報告による健康関連QOLが記録される。JRPはADPKDおよびARPKD患者を対象とした日本初の全国規模の登録研究である。

  • Association between Serum Zinc and All-Cause Mortality in Patients Undergoing Maintenance Hemodialysis: The Osaka Dialysis Complication Study (ODCS).

    Shinya Nakatani, Tetsuo Shoji, Fumiyuki Morioka, Rino Nakaya, Mayuko Ueda, Hideki Uedono, Akihiro Tsuda, Tomoaki Morioka, Hisako Fujii, Hisako Yoshida, Katsuhito Mori, Masanori Emoto

    Nutrients   16 ( 19 )   2024.09

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    Publishing type：Research paper (scientific journal)   International / domestic magazine：International journal  

    BACKGROUND/OBJECTIVES: Zinc is an essential microelement, and its deficiency is common in patients undergoing hemodialysis. However, the association between serum zinc and mortality in these patients remains unclear. The aim of this study was to explore the possible association between serum zinc levels and all-cause mortality in prevalent patients with kidney failure on maintenance hemodialysis. METHODS: This was a prospective cohort study of maintenance hemodialysis patients followed up for 5 years. The key exposure was serum zinc level measured at baseline, and the outcome was all-cause mortality. Their association was analyzed using Cox proportional hazard models. RESULTS: Among 1662 eligible patients selected for this analysis, 468 (28%) died. Lower serum zinc levels were associated with a higher risk for mortality, independent of the major demographic factors and factors including mineral and bone disorder and renal anemia. However, this association was no longer significant when adjusted for serum albumin. Because there was a close correlation between serum zinc and albumin levels, we performed further analyses in which participants were categorized into four groups by median serum zinc (68 µg/dL) and albumin (3.7 g/dL) levels. In the lower serum albumin groups, risk of death was significantly higher in those with lower zinc than those with higher zinc levels, whereas such a difference was not significant in the high serum albumin groups. CONCLUSIONS: In patients undergoing maintenance hemodialysis with lower serum albumin levels, a lower serum zinc level was associated with a higher risk of mortality.

    DOI： 10.3390/nu16193270

    PubMed

  • Association between plasma aldosterone concentration and intraglomerular hemodynamics in primary aldosteronism.

    Hideki Uedono, Masafumi Kurajoh, Norikazu Toi, Akihiro Tsuda, Kento Shinmaru, Yuya Miki, Shinya Nakatani, Yuki Nagata, Tomoaki Morioka, Katsuhito Mori, Yasuo Imanishi, Masanori Emoto

    American journal of hypertension   37 ( 10 )   801 - 809   2024.09（ ISSN:0895-7061 ）

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    Publishing type：Research paper (scientific journal)   International / domestic magazine：International journal  

    BACKGROUND/AIMS: In primary aldosteronism (PA), aldosterone could affect glomerular hemodynamics by elevating renal vascular resistance and glomerular capillary pressure. However, the relationship between plasma aldosterone concentrations (PAC) and glomerular hemodynamics including efferent arteriolar resistance (Re), afferent arteriolar resistance (Ra) in humans is still unclear. The aim of this study was to investigate the relationships of PAC with intraglomerular hemodynamic parameters in patients with PA. METHODS: An observational study of glomerular hemodynamics was performed using simultaneous measurements of plasma clearance of para-aminohippurate and inulin (Cin; glomerular filtration rate (GFR)) in 17 patients with PA. Kidney function was evaluated by Cin, estimated GFR based on serum creatine (eGFRcre) and serum cystatin C (eGFRcys) and creatine clearance (Ccr). Intraglomerular hemodynamic parameters, including Re, Ra, and intraglomerular hydrostatic pressure (Pglo) were calculated using Gomez's formulae. RESULTS: In the 17 PA cases, PAC was significantly correlated with Cin (rho=0.752, p=0.001) and eGFRcys (rho=0.567, p=0.018), but was not correlated witheGFRcreand Ccr. PAC was also significantly correlated with Pglo, Re, and urinary protein/day (rho=0.775, p=0.0004, rho=0.625, p=0.009, and rho=0.625, p=0.007, respectively). Multivariable regression analysis showed that PAC was significantly associated with Cin and Re. In comparing aldosterone producing adenoma (APA) and non-APA cases, Cin was significantly elevated in APA (p=0.037), whereas eGFRcre, eGFRcys, and Ccr were not. Re tended to be higher in APA (p=0.064). CONCLUSIONS: These results suggest high aldosterone cause glomerular hyperfiltration by constricting Re. Cin, but not eGFRcre and Ccr, may be useful for evaluating kidney function in PA.

    DOI： 10.1093/ajh/hpae071

    PubMed

  • New-onset Kidney Biopsy-proven Membranous Nephropathy Induced End-stage Kidney Disease in a Living Donor

    Morioka Fumiyuki, Nakatani Shinya, Mori Katsuhito, Naganuma Toshihide, Yamasaki Takeshi, Uedono Hideki, Tsuda Akihiro, Ishimura Eiji, Uchida Junji, Emoto Masanori

    Internal Medicine   63 ( 18 )   2537 - 2541   2024.09（ ISSN:0918-2918 ） （ eISSN:13497235 ）

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    Publishing type：Research paper (scientific journal)   International / domestic magazine：Domestic journal  

    <p>Thirteen years after kidney donation, a 70-year-old man was referred to a nephrologist because of proteinuria. The serum creatinine, albumin, and urinary protein levels were 2.39 mg/dL, 3.0 g/dL, and 6.72 g/gCr, respectively. A kidney biopsy revealed thickening of the glomerular basement membrane with sub-epithelial deposits, suggesting membranous nephropathy. Considering the apparent interstitial fibrosis and diffuse glomerulosclerosis, supportive treatment was chosen. However, 11 months after the kidney biopsy, hemodialysis was required. The present case constitutes an important teaching point, as glomerular disease can occur in living donors and require careful and long-term medical checkup examinations. </p>

    DOI： 10.2169/internalmedicine.2814-23

    PubMed

    CiNii Research

  • 血液透析患者の胃十二指腸ランタン吸着症の1症例

    藤本 高大, 好本 雅也, 香束 昌宏, 小阪 聡, 北野 裕子, 仲谷 慎也, 東本 一成, 越智 正博, 河合 誠朗, 垣谷 隆介, 石村 栄治

    大阪透析研究会会誌   41 ( 2 )   197 - 198   2024.09（ ISSN:0912-6937 ）

  • 血液透析患者の胃十二指腸ランタン吸着症の1症例

    好本 雅也, 藤本 高大, 東本 一成, 納谷 幸佑, 香束 昌宏, 小阪 聡, 北野 裕子, 仲谷 慎也, 越智 正博, 河合 誠朗, 垣谷 隆介, 石村 栄治

    日本腎臓学会誌   66 ( 6-W )   1074 - 1074   2024.09（ ISSN:0385-2385 ）

  • 難治性胸腹水を呈し,Congo red染色が陽性となった正常血圧性強皮症腎クリーゼの剖検例

    上殿 英記, 曽根 一真, 好本 雅也, 森岡 史行, 仲谷 慎也, 津田 昌宏, 森 克仁, 繪本 正憲

    日本腎臓学会誌   66 ( 6-W )   1079 - 1079   2024.09（ ISSN:0385-2385 ）

  • 生体ドナーにおける腎生検で確認された膜性腎症による末期腎疾患の新規発症(New-onset Kidney Biopsy-proven Membranous Nephropathy Induced End-stage Kidney Disease in a Living Donor)

    Morioka Fumiyuki, Nakatani Shinya, Mori Katsuhito, Naganuma Toshihide, Yamasaki Takeshi, Uedono Hideki, Tsuda Akihiro, Ishimura Eiji, Uchida Junji, Emoto Masanori

    Internal Medicine   63 ( 18 )   2537 - 2541   2024.09（ ISSN:0918-2918 ）

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    症例は70歳男性で、タンパク尿のために来院した。患者は56歳時に腎移植ドナーとなっており、腎提供後6年は腎機能が維持されていたが、尿中タンパク陽性となり、アジルサルタン治療を開始していた。腎提供後13年時に紹介来院した際の血清クレアチニンは2.39mg/dL、推算糸球体濾過量は22.1mL/分/1.73m2、血清アルブミンは3.0g/dL、尿中タンパクは6.72g/gCrであった。入院3日目に開腹腎生検を行い、上皮下沈着物を伴う糸球体基底膜の肥厚が明らかとなり、ステージIV膜性腎症(MN)と診断した。胸腹部CTで悪性腫瘍は示されず、上下部消化管内視鏡検査でも明らかな消化管腫瘍は認められなかった。MNの二次性原因のスクリーニングは陰性であったことから、原発性MNと診断した。著明な間質線維化とび漫性糸球体硬化症を考慮し、慢性腎臓病に対する支持療法を行ったが、腎生検の11ヵ月後に血液透析を要する末期腎疾患となった。

  • 剖検にて免疫抑制薬関連リンパ増殖性疾患に伴う回腸穿孔と診断したANCA関連血管炎・RAの一例

    八幡 友貴, 仲谷 慎也, 加藤 雅大, 森岡 史行, 曽根 一真, 上殿 英記, 田中 さやか, 津田 昌宏, 森 克仁, 孝橋 賢一, 繪本 正憲

    日本腎臓学会誌   66 ( 6-W )   1099 - 1099   2024.09（ ISSN:0385-2385 ）

  • Dapagliflozin administration for 1 year promoted kidney enlargement in patient with ADPKD.

    Shinya Nakatani, Fumiyuki Morioka, Hideki Uedono, Akihiro Tsuda, Katsuhito Mori, Masanori Emoto

    CEN case reports   13 ( 4 )   284 - 289   2024.08

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    Publishing type：Research paper (scientific journal)   International / domestic magazine：Domestic journal  

    To date, there is insufficient evidence regarding use of sodium-glucose cotransporter-2 (SGLT2) inhibitors for patients with autosomal-dominant polycystic kidney disease (ADPKD), as such cases have been excluded from previous clinical trials exploring the kidney protection effects of such medications. Here, findings of an ADPKD patient who received dapagliflozin, a selective SGLT2 inhibitor, for 1 year are presented. A 38-year-old woman with a family history of ADPKD wished for treatment with dapagliflozin. After starting administration at 10 mg/day, total kidney volume (TKV) continued to increase, from 1641 to 1764 mL after 84 days and then to 2297 mL after 340 days. The estimated glomerular filtration rate (eGFR) was also decreased from 67.3 to 56.2 mL/min/1.73 m2, and then to 51.4 mL/min/1.73 m2 at those times. Immediately after discontinuation of dapagliflozin, TKV and eGFR were slightly improved to 2263 mL and 55.1 mL/min/1.73 m2, respectively. Following a review of basic research studies, we consider that increased intratubular urinary osmotic pressure, compensatory glucose reabsorption by sodium-glucose cotransporter-1 in the late proximal tubule, and hypertrophy shown in collected cells caused by increased vasopressin may be associated with ADPKD disease progression. Caution may be needed when administering dapagliflozin to patients with ADPKD.

    DOI： 10.1007/s13730-023-00840-4

    PubMed

  • ダパグリフロジン投与を1年間続けたことで腎腫大が顕著となったADPKDの1例(Dapagliflozin administration for 1 year promoted kidney enlargement in patient with ADPKD)

    Nakatani Shinya, Morioka Fumiyuki, Uedono Hideki, Tsuda Akihiro, Mori Katsuhito, Emoto Masanori

    CEN Case Reports   13 ( 4 )   284 - 289   2024.08

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    38歳女性。常染色体優性多発性嚢胞腎(ADPKD)の家族歴が母を含め4人存在し、本人も16歳時にADPKDと診断されていた。当院初診時点では高血圧症に対しオルメサルタン20mg/日を投与されていた。推算糸球体濾過量(eGFR)は74.6mL/分/1.73m2であった。総腎容積は、当院初診の3年前に行われたCT検査では1417mLであったが、今回は1641mLとなっていた。初診から9ヵ月後にはeGFRが67.3へ低下した。初診2年後に患者がナトリウム-グルコース共輸送体2(SGLT2)阻害薬での治療を希望したためダパグリフロジン10mg/日を開始した。開始3ヵ月後に評価した総腎容積は1764mLと著明に増加していたため、ダパグリフロジン中止およびトルバプタン治療を提案したが、却下された。以上より、ダパグリフロジン投与を1年間続けた。終了時点でのeGFRは51.4、総腎容積は2297mLであった。その後に患者はトルバプタン投与開始に同意し、1ヵ月後にはeGFRは55.1、総腎容積は2263mLに改善した。

  • 「エビデンスに基づく慢性腎臓病診療ガイドライン2023」の要点(Essential points from evidence-based clinical practice guideline for chronic kidney disease 2023)

    Maruyama Shoichi, Kanda Eiichiro, Kume Shinji, Isaka Yoshitaka, Ishikura Kenji, Usui Joichi, Uchida Keiko, Okada Hirokazu, Konta Tsuneo, Saito Chie, Suzuki Hiroshi, Tanaka Tetsuhiro, Tsuboi Naotake, Nakagawa Naoki, Nishio Saori, Fukami Kei, Honda Hirokazu, Masutani Kosuke, Yokoyama Keitaro, Wada Jun, Wada Takashi, Wada Takehiko, Asanuma Katsuhiko, Asahi Koichi, Abe Masanori, Ishimoto Takuji, Kawanami Daiji, Komaba Hirotaka, Sada Kenei, Sofue Tadashi, Nakatani Shinya, Nakatsuka Atsuko, Hibino Satoshi, Fujii Hideki, Hoshino Junichi, Hosojima Michihiro, Maeshima Akito, Maruyama Yukio, Moriyama Takahito, Yasuda Hideo, Yasuda Yoshinari, Yamamoto Suguru, Kosugi Tomoki, Japanese Society of Nephrology

    Clinical and Experimental Nephrology   28 ( 6 )   473 - 495   2024.06（ ISSN:1342-1751 ）

  • Enhanced inhibitory activity of compounds containing purine scaffolds compared to protein kinase CK2α considering crystalline water.

    Nishiwaki K, Nakatani S, Nakamura S, Yoshioka K, Nakagawa E, Tsuyuguchi M, Kinoshita T, Nakanishi I

    RSC medicinal chemistry   15 ( 4 )   1274 - 1282   2024.04（ ISSN:26328682 ）

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  • Histologic and Clinical Factors Associated with Kidney Outcomes in IgA Vasculitis Nephritis.

    Sean J Barbour, Rosanna Coppo, Lee Er, Evangeline Pillebout, Maria Luisa Russo, Charles E Alpers, Agnes B Fogo, Franco Ferrario, J Charles Jennette, Ian S D Roberts, H Terence Cook, Jie Ding, Baige Su, Xuhui Zhong, Fernando C Fervenza, Ladan Zand, Licia Peruzzi, Laura Lucchetti, Ritsuko Katafuchi, Yuko Shima, Norishige Yoshikawa, Daisuke Ichikawa, Yusuke Suzuki, Luisa Murer, Robert J Wyatt, Catherine Park, Raoul D Nelson, JoAnn H Narus, Scott Wenderfer, Duvuru Geetha, Eric Daugas, Renato C Monteiro, Shinya Nakatani, Antonio Mastrangelo, Matti Nuutinen, Mikael Koskela, Lutz T Weber, Agnes Hackl, Martin Pohl, Carmine Pecoraro, Nobuo Tsuboi, Takashi Yokoo, Ito Takafumi, Shouichi Fujimoto, Giovanni Conti, Domenico Santoro, Marco Materassi, Hong Zhang, Sufang Shi, Zhi-Hong Liu, Vladimir Tesar, Dita Maixnerova, Carmen Avila-Casado, Ingeborg Bajema, Antonella Barreca, Jan U Becker, Jessica M Comstock, Virgilius Cornea, Karen Eldin, Loren Herrera Hernandez, Jean Hou, Kensuke Joh, Mercury Lin, Nidia Messias, Andrea Onetti Muda, Fabio Pagni, Francesca Diomedi-Camassei, Heikki Tokola, Maria D'Armiento, Maximilian Seidl, Avi Rosenberg, Aurélie Sannier, Maria Fernanda Soares, Suxia Wang, Caihong Zeng, Mark Haas

    Clinical journal of the American Society of Nephrology : CJASN   19 ( 4 )   438 - 451   2024.04（ ISSN:1555-9041 ）

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    Publishing type：Research paper (scientific journal)   International / domestic magazine：International journal  

    BACKGROUND: Nephritis is a common manifestation of IgA vasculitis and is morphologically indistinguishable from IgA nephropathy. While MEST-C scores are predictive of kidney outcomes in IgA nephropathy, their value in IgA vasculitis nephritis has not been investigated in large multiethnic cohorts. METHODS: Biopsies from 262 children and 99 adults with IgA vasculitis nephritis ( N =361) from 23 centers in North America, Europe, and Asia were independently scored by three pathologists. MEST-C scores were assessed for correlation with eGFR/proteinuria at biopsy. Because most patients ( N =309, 86%) received immunosuppression, risk factors for outcomes were evaluated in this group using latent class mixed models to identify classes of eGFR trajectories over a median follow-up of 2.7 years (interquartile range, 1.2-5.1). Clinical and histologic parameters associated with each class were determined using logistic regression. RESULTS: M, E, T, and C scores were correlated with either eGFR or proteinuria at biopsy. Two classes were identified by latent class mixed model, one with initial improvement in eGFR followed by a late decline (class 1, N =91) and another with stable eGFR (class 2, N =218). Class 1 was associated with a higher risk of an established kidney outcome (time to ≥30% decline in eGFR or kidney failure; hazard ratio, 5.84; 95% confidence interval, 2.37 to 14.4). Among MEST-C scores, only E1 was associated with class 1 by multivariable analysis. Other factors associated with class 1 were age 18 years and younger, male sex, lower eGFR at biopsy, and extrarenal noncutaneous disease. Fibrous crescents without active changes were associated with class 2. CONCLUSIONS: Kidney outcome in patients with biopsied IgA vasculitis nephritis treated with immunosuppression was determined by clinical risk factors and endocapillary hypercellularity (E1) and fibrous crescents, which are features that are not part of the International Study of Diseases of Children classification.

    DOI： 10.2215/CJN.0000000000000398

    PubMed

  • Differential associations of fetuin-A and calcification propensity with cardiovascular events and subsequent mortality in patients undergoing hemodialysis.

    Katsuhito Mori, Tetsuo Shoji, Shinya Nakatani, Hideki Uedono, Akinobu Ochi, Hisako Yoshida, Yasuo Imanishi, Tomoaki Morioka, Yoshihiro Tsujimoto, Makoto Kuro-O, Masanori Emoto

    Clinical kidney journal   17 ( 3 )   sfae042   2024.03（ ISSN:2048-8505 ）

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    Publishing type：Research paper (scientific journal)   International / domestic magazine：International journal  

    BACKGROUND: Fetuin-A inhibits precipitation of calcium-phosphate crystals by forming calciprotein particles (CPP). A novel T50 test, which measures transformation time from primary to secondary CPP, is an index for calcification propensity. Both lower fetuin-A and shorter T50 levels were associated with cardiovascular disease (CVD) risk in patients with chronic kidney disease (CKD). Extremely high risk for CVD death in advanced CKD patients consists of high-incidental CVD event and high mortality after CVD event. To date, it is unclear whether fetuin-A and/or T50 can equally predict each CVD outcome. METHODS: This prospective cohort study examined patients undergoing maintenance hemodialysis. The exposures were fetuin-A and T50. The outcomes of interests were new CVD events and subsequent deaths. The patients were categorized into tertiles of fetuin-A or T50 (T1 to T3). RESULTS: We identified 190 new CVD events during the 5-year follow-up of the 513 patients and 59 deaths subsequent to the CVD events during 2.5-year follow-up. A lower fetuin-A but not T50 was significantly associated with new CVD events [subdistribution hazard ratio (HR) 1.73, 95% confidence interval (CI) 1.15-2.61, P = .009 for T1 vs T3]. In contrast, a shorter T50 but not fetuin-A was a significant predictor of deaths after CVD events (HR 3.31, 95% CI 1.42-7.74, P = .006 for T1 + T2 vs T3). A lower fetuin-A was predictive of new CVD events, whereas a shorter T50 was more preferentially associated with subsequent death. CONCLUSION: These results indicate that fetuin-A and T50 are involved in cardiovascular risk in different manners.

    DOI： 10.1093/ckj/sfae042

    PubMed

  • Correction to: Public support for patients with intractable diseases in Japan: impact on clinical indicators from nationwide registries in patients with autosomal dominant polycystic kidney disease.

    Hiroshi Kataoka, Yosuke Shimada, Tomonori Kimura, Saori Nishio, Shinya Nakatani, Toshio Mochizuki, Ken Tsuchiya, Junichi Hoshino, Fumihiko Hattanda, Haruna Kawano, Kazushige Hanaoka, Sumi Hidaka, Daisuke Ichikawa, Eiji Ishikawa, Kiyotaka Uchiyama, Hiroki Hayashi, Shiho Makabe, Shun Manabe, Michihiro Mitobe, Akinari Sekine, Tatsuya Suwabe, Hirayasu Kai, Mahiro Kurashige, Koichi Seta, Keiji Shimazu, Tomofumi Moriyama, Mai Sato, Tadashi Otsuka, Kan Katayama, Wataru Shimabukuro, Takuya Fujimaru, Kenichiro Miura, Koichi Nakanishi, Shigeo Horie, Kengo Furuichi, Hirokazu Okada, Ichiei Narita, Satoru Muto

    Clinical and experimental nephrology   28 ( 1 )   82 - 83   2024.01（ ISSN:1342-1751 ）

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    Publishing type：Research paper (scientific journal)   International / domestic magazine：Domestic journal  

    BACKGROUND: Clinical practice guidelines recommend antihypertensive and tolvaptan therapies for patients with autosomal dominant polycystic kidney disease (ADPKD) in Japan. However, tolvaptan therapy may pose an economic burden. The Japanese Ministry of Health, Labour and Welfare supports patients with intractable diseases. This study aimed to confirm the impact of the intractable disease system in Japan on the clinical treatment of ADPKD. METHODS: We analyzed the data of 3768 patients with ADPKD having a medical subsidy certificate from the Japanese Ministry of Health, Labour and Welfare in 2015-2016. The following quality indicators were use: the adherence rate to the 2014 clinical practice guideline for polycystic kidney disease (prescription rates of antihypertensive agents and tolvaptan in this cohort) and the number of Japanese patients with ADPKD nationwide started on renal replacement therapy in 2014 and 2020. RESULTS: Compared with new applications from 2015 to 2016, the prescription rates of antihypertensives and tolvaptan for the indicated patients at the 2017 renewal application increased by 2.0% (odds ratio = 1.41, p = 0.008) and 47.4% (odds ratio = 10.1, p > 0.001), respectively. These quality indicators improved with antihypertensive treatment, especially in patients with chronic kidney disease stages 1-2 (odds ratio = 1.79, p = 0.013) and in those aged < 50 years (odds ratio = 1.70, p = 0.003). The number of patients with ADPKD who were started on renal replacement therapy in Japan decreased from 999 in 2014 to 884 in 2020 in the nationwide database (odds ratio = 0.83, p < 0.001). CONCLUSIONS: The Japanese public intractable disease support system contributes to improvement of ADPKD treatment.

    DOI： 10.1007/s10157-023-02426-x

    PubMed

  • エビデンスに基づくCKD診療ガイドライン2023

    丸山 彰一, 神田 英一郎, 久米 真司, 猪阪 善隆, 石倉 健司, 臼井 丈一, 内田 啓子, 岡田 浩一, 今田 恒夫, 斎藤 知栄, 鈴木 仁, 田中 哲洋, 坪井 直毅, 中川 直樹, 西尾 妙織, 深水 圭, 本田 浩一, 升谷 耕介, 横山 啓太郎, 和田 淳, 和田 隆志, 和田 健彦, 淺沼 克彦, 旭 浩一, 阿部 雅紀, 石本 卓嗣, 川浪 大治, 駒場 大峰, 佐田 憲映, 祖父江 理, 仲谷 慎也, 中司 敦子, 日比野 聡, 藤井 秀毅, 星野 純一, 細島 康宏, 前嶋 明人, 丸山 之雄, 森山 能仁, 安田 日出夫, 安田 宜成, 山本 卓, 石川 英二, 市川 大介, 伊藤 健太, 岩下 山連, 上田 誠二, 上田 裕之, 上村 治, 江里口 雅裕, 大島 恵, 大矢 昌樹, 岡本 孝之, 小口 英世, 小野寺 正輝, 貝藤 裕史, 忰田 亮平, 片山 鑑, 金子 佳代子, 上條 祐司, 神谷 雅人, 唐澤 一徳, 川口 武彦, 川嶋 聡子, 神田 祥一郎, 菅野 義彦, 菊池 洋平, 木原 正夫, 金口 翔, 栗田 宜明, 桑原 頌治, 桑原 孝成, 小泉 賢洋, 河野 圭志, 小坂 志保, 後藤 俊介, 坂口 悠介, 佐藤 隆太, 佐藤 涼介, 座間味 亮, 重冨 奈穂子, 柴田 茂, 島袋 渡, 清水 さやか, 新家 俊郎, 杉本 圭相, 杉本 俊郎, 孫 大輔, 高井 奈美, 田口 博基, 竹内 裕紀, 辰元 為仁, 田中 健一, 田邉 起, 田村 功一, 辻 章志, 辻田 誠, 寺野 千香子, 遠山 直志, 戸田 晋, 永井 恵, 中沢 大悟, 長洲 一, 中野 敏昭, 長浜 正彦, 中屋 来哉, 西 健太朗, 西脇 宏樹, 延山 理恵, 花房 規男, 濱崎 祐子, 濱田 陸, 樋口 一世, 深町 大介, 藤井 直彦, 藤崎 毅一郎, 程内 栄子, 本田 崇, 毎熊 政行, 松木 孝樹, 三浦 健一郎, 三崎 太郎, 水野 智博, 三村 洋美, 宮本 聡, 宮脇 義亜, 牟田 久美子, 村田 智博, 谷澤 雅彦, 柳原 剛, 矢野 裕一朗, 山岸 昌一, 横井 秀基, 吉崎 健, 脇 大輔, 渡邊 博志, 渡辺 博文, 渡辺 昌文, 朝比奈 悠太, 畔上 達彦, 飯田 倫理, 井口 昭, 井口 智洋, 井熊 大輔, 石井 輝, 石塚 喜世伸, 泉 裕一郎, 板野 精之, 市川 大介, 市川 一誠, 伊藤 雄伍, 伊藤 辰将, 内田 大介, 大熊 輝之, 大田 南欧美, 大西 康博, 大野 祥子, 大畑 拓也, 大山 勝宏, 岡 香奈子, 岡 樹史, 緒方 浩顕, 小田 圭子, 小田 直樹, 小原 由紀, 梶保 祐子, 梶本 幸男, 片桐 大輔, 蒲澤 秀門, 神吉 智子, 亀井 啓太, 川口 祐輝, 河原崎 宏雄, 木村 浩, 工藤 光介, 黒岡 直子, 桑形 尚吾, 高上 紀之, 古志 衣里, 近藤 悠希, 齋木 良介, 齋藤 友広, 齋藤 浩孝, 佐々木 彰, 佐藤 浩司, 猿渡 淳二, 志田 龍太郎, 菅原 亮佑, 鈴木 克彦, 諏訪部 達也, 平 大樹, 高士 祐一, 武田 尚子, 武田 有記, 田中 茂, 田中 祥子, 谷口 美紗, 塚本 俊一郎, 鶴田 悠木, 寺下 真帆, 土井 洋平, 徳永 孝史, 泊 弘毅, 鳥越 健太, 内藤 順子, 中井 健太郎, 長岡 由女, 中川 詩織, 中川 輝政, 中島 章雄, 中島 悠里, 永田 大, 永野 伸郎, 中村 祐貴, 永山 泉, 西沢 慶太郎, 西堀 暢浩, 忍頂寺 毅史, 服部 洸輝, 花井 豪, 濱田 昌実, 原田 真, 春原 浩太郎, 平井 健太, 平林 陽介, 福田 俊悟, 藤澤 諭, 藤丸 拓也, 堀越 慶輔, 本城 保菜美, 松尾 浩司, 丸山 啓介, 宮内 隆政, 宮崎 絋平, 武藤 正浩, 村島 美穂, 矢野 彰三, 山内 壮作, 山口 哲志, 山田 俊輔, 山原 康佑, 山本 脩人, 山脇 正裕, 湯浅 貴博, 吉田 学郎, 芦村 龍一, 若林 華恵, 若松 拓也, 渡邉 公雄, 渡邉 健太郎, 渡邉 周平, 小杉 智規, 日本腎臓学会

    日本腎臓学会誌   66 ( 1 )   i,1 - xxxii,1   2024.01（ ISSN:0385-2385 ）

  • Novel Digenic Variants in COL4A4 and COL4A5 Causing X-Linked Alport Syndrome: A Case Report.

    Hideki Uedono, Katsuhito Mori, Shinya Nakatani, Kohei Watanabe, Rino Nakaya, Fumiyuki Morioka, Kazuma Sone, Chie Ono, Junko Hotta, Akihiro Tsuda, Naoya Morisada, Toshiyuki Seto, Kandai Nozu, Masanori Emoto

    Case reports in nephrology and dialysis   14 ( 1 )   1 - 9   2024.01（ ISSN:2296-9705 ）

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    Publishing type：Research paper (scientific journal)   International / domestic magazine：International journal  

    INTRODUCTION: Alport syndrome (AS) is a hereditary, progressive kidney disease characterized by structural abnormalities and dysfunction of the glomerular basement membrane (GBM). AS is classified as X-linked, autosomal, and digenic. The number of cases of digenic AS has increased, but the genotype-phenotype correlation of patient with digenic AS is still unclear. Here, we present a case of digenic AS with novel digenic missense variants in COL4A4 (c.827G>C, p.Gly276Ala) and COL4A5 (c.4369G>C, p.Gly1457Arg). CASE PRESENTATION: The patient was a 29-year-old Japanese man suffering from persistent microscopic hematuria and proteinuria without kidney function impairment. Kidney biopsy showed focal interstitial foam cell infiltration, global and segmental glomerulosclerosis. Immunofluorescence staining for collagen IV α5 was almost negative in the GBM and Bowman's capsule. Electron microscopy revealed irregular thickening with lamellation and segmental thinning of the GBM. Clinical and pathological findings were consistent with AS. Comprehensive next-generation sequencing revealed a heterozygous missense variant in COL4A4 (c.827G>C, p.Gly276Ala) in exon 1 and a hemizygous missense variant in COL4A5 (c.4369G>C, p.Gly1457Arg) in exon 49 on the patient's paternal and maternal alleles, respectively. The same digenic variants were detected in his sister, and she also showed a similar phenotype. After treatment with angiotensin-converting enzyme inhibitors, proteinuria decreased from 2.3 to 1.1 g/g creatinine, but occult blood persisted. During follow-up, kidney function has been preserved. CONCLUSION: The novel genotype of our case provides more information on the genotype-phenotype correlation of digenic XLAS, although long-term follow-up is required. The findings in the present case also indicate the importance of genetic tests for family members of a patient diagnosed with digenic AS.

    DOI： 10.1159/000535493

    PubMed

  • Effects of canagliflozin on kidney oxygenation evaluated using blood oxygenation level-dependent MRI in patients with type 2 diabetes.

    Katsuhito Mori, Tsutomu Inoue, Yuri Machiba, Hideki Uedono, Shinya Nakatani, Masahiro Ishikawa, Satsuki Taniuchi, Yutaka Katayama, Akira Yamamoto, Naoki Kobayashi, Eito Kozawa, Taro Shimono, Yukio Miki, Hirokazu Okada, Masanori Emoto

    Frontiers in endocrinology   15   1451671 - 1451671   2024（ ISSN:1664-2392 ） （ eISSN:1664-2392 ）

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    Publishing type：Research paper (scientific journal)   International / domestic magazine：International journal  

    BACKGROUND: Recent clinical studies suggest protective effects of SGLT2 inhibitors on kidney disease outcome. Chronic hypoxia has a critical role in kidney disease development, thus we speculated that canagliflozin, an SGLT2 inhibitor, can improve kidney oxygenation. METHODS: A single-arm study was conducted to investigate the effects of canagliflozin on T2* value, which reflects oxygenation level, in patients with type 2 diabetes (T2D) using repeated blood oxygenation level-dependent MRI (BOLD MRI) examinations. Changes in cortical T2* from before (Day 0) to after single-dose treatment (Day 1) and after five consecutive treatments (Day 5) were evaluated using 12-layer concentric objects (TLCO) and region of interest (ROI) methods. RESULTS: In the full analysis set (n=14 patients), the TLCO method showed no change of T2* with canagliflozin treatment, whereas the ROI method found that cortical T2* was significantly increased on Day 1 but not on Day 5. Sensitivity analysis using TLCO in 13 well-measured patients showed that canagliflozin significantly increased T2* on Day 1 with no change on Day 5, whereas a significant improvement in cortical T2* following canagliflozin treatment was found on both Day 1 and 5 using ROI. CONCLUSIONS: Short-term canagliflozin treatment may improve cortical oxygenation and lead to better kidney outcomes in patients with T2D.

    DOI： 10.3389/fendo.2024.1451671

    PubMed

  • Short-Term Dapagliflozin Administration in Autosomal Dominant Polycystic Kidney Disease-A Retrospective Single-Arm Case Series Study.

    Fumiyuki Morioka, Shinya Nakatani, Hideki Uedono, Akihiro Tsuda, Katsuhito Mori, Masanori Emoto

    Journal of clinical medicine   12 ( 19 )   2023.10（ ISSN:2077-0383 ）

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    Publishing type：Research paper (scientific journal)   International / domestic magazine：International journal  

    Treatment with sodium-glucose cotransporter-2 (SGLT2) inhibitors may have pleiotropic and beneficial effects in terms of ameliorating of risk factors for the progression of autosomal dominant polycystic kidney disease (ADPKD). However, there is insufficient evidence regarding the use of these drugs in patients with ADPKD, as they were excluded from several clinical trials conducted to explore kidney protection provided by SGLT2 inhibitors. This retrospective single-arm case series study was performed to investigate the effects of dapagliflozin, a selective SGLT2 inhibitor administered at 10 mg/day, on changes in height-adjusted kidney volume (htTKV) and estimated glomerular filtration rate (eGFR) in ADPKD patients. During a period of 102 ± 20 days (range 70-156 days), eGFR was decreased from 47.9 (39.7-56.9) to 40.8 (33.7-44.5) mL/min/1.73 m2 (p < 0.001), while htTKV was increased from 599 (423-707) to 617 (446-827) mL/m (p = 0.002) (n = 20). The annual increase in htTKV rate was significantly promoted, and urinary phosphate change was found to be correlated with the change in htTKV (rs = 0.575, p = 0.020). In the examined patients, eGFR was decreased and htTKV increased during short-term administration of dapagliflozin. To confirm the possibility of the effects of dapagliflozin on ADPKD, additional interventional studies are required.

    DOI： 10.3390/jcm12196341

    PubMed

  • Public support for patients with intractable diseases in Japan: impact on clinical indicators from nationwide registries in patients with autosomal dominant polycystic kidney disease.

    Kataoka H, Shimada Y, Kimura T, Nishio S, Nakatani S, Mochizuki T, Tsuchiya K, Hoshino J, Hattanda F, Kawano H, Hanaoka K, Hidaka S, Ichikawa D, Ishikawa E, Uchiyama K, Hayashi H, Makabe S, Manabe S, Mitobe M, Sekine A, Suwabe T, Kai H, Kurashige M, Seta K, Shimazu K, Moriyama T, Sato M, Otsuka T, Katayama K, Shimabukuro W, Fujimaru T, Miura K, Nakanishi K, Horie S, Furuichi K, Okada H, Narita I, Muto S

    Clinical and experimental nephrology   27 ( 10 )   809 - 818   2023.10（ ISSN:1342-1751 ）

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  • 日本における難病患者向けの公的支援　常染色体優性多発性嚢胞腎患者における全国レジストリからの臨床指標に対する影響(Public support for patients with intractable diseases in Japan: impact on clinical indicators from nationwide registries in patients with autosomal dominant polycystic kidney disease)

    Kataoka Hiroshi, Shimada Yosuke, Kimura Tomonori, Nishio Saori, Nakatani Shinya, Mochizuki Toshio, Tsuchiya Ken, Hoshino Junichi, Hattanda Fumihiko, Kawano Haruna, Hanaoka Kazushige, Hidaka Sumi, Ichikawa Daisuke, Ishikawa Eiji, Uchiyama Kiyotaka, Hayashi Hiroki, Makabe Shiho, Manabe Shun, Mitobe Michihiro, Sekine Akinari, Suwabe Tatsuya, Kai Hirayasu, Kurashige Mahiro, Seta Koichi, Shimazu Keiji, Moriyama Tomofumi, Sato Mai, Otsuka Tadashi, Katayama Kan, Shimabukuro Wataru, Fujimaru Takuya, Miura Kenichiro, Nakanishi Koichi, Horie Shigeo, Furuichi Kengo, Okada Hirokazu, Narita Ichiei, Muto Satoru

    Clinical and Experimental Nephrology   27 ( 10 )   809 - 818   2023.10（ ISSN:1342-1751 ）

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    日本の常染色体優性多発性嚢胞腎(ADPKD)の臨床設定に対する難病制度の影響を調査し、多発性嚢胞腎のために作成された臨床診療ガイドラインの遵守率を明らかにした。2015～2016年に厚生労働省から医療費助成証明書を得たADPKD患者3768例(男性49.6%、平均51.1歳)のデータを分析した。このうち、2085例(男性49.3%、平均53.7歳)は2017年に日本の難病制度からの支援を再申請した。2015～2016年の新規申請に比べて2017年の更新申請時の必要が示された患者に対する降圧剤とトルバプタンの処方率はそれぞれ2.0%、47.4%増加した。降圧剤の処方率の改善は、特に慢性腎臓病ステージ1～2の患者と50歳未満の患者で観察された。全国データベースにおいて、日本で腎代替療法を開始したADPKD患者数は2014年の999例から2020年には884例まで減少した。以上より、日本の公的難病支援制度はADPKD治療の改善に寄与していると考えられた。

  • ダパグリフロジン投与後に嚢胞増大と腎機能悪化が顕著になったADPKDの一例

    仲谷 慎也, 森岡 史行, 上殿 英記, 津田 昌宏, 森 克仁, 繪本 正憲

    日本腎臓学会誌   65 ( 6-W )   767 - 767   2023.09（ ISSN:0385-2385 ）

  • 高度の低Ca血症(4.5mg/dL)を呈したアルコール多飲者の急性腎障害の一例

    好本 雅也, 香束 昌宏, 北野 裕子, 越智 章展, 仲谷 慎也, 垣谷 隆介, 石村 栄治

    日本腎臓学会誌   65 ( 6-W )   759 - 759   2023.09（ ISSN:0385-2385 ）

  • 難治性胸腹水と急性腎障害を来し,剖検にて全身性強皮症と診断した1例

    曽根 一真, 上殿 英記, 中舎 璃乃, 森岡 史行, 仲谷 慎也, 津田 昌宏, 森 克仁, 繪本 正憲

    大阪透析研究会会誌   40 ( 2 )   172 - 172   2023.09（ ISSN:0912-6937 ）

  • 血液透析導入となった悪性高血圧患者の一例

    渡邊 亘平, 津田 昌宏, 中舎 璃乃, 森岡 史行, 曽根 一真, 上殿 英記, 仲谷 慎也, 森 克仁, 繪本 正憲

    大阪透析研究会会誌   40 ( 2 )   173 - 173   2023.09（ ISSN:0912-6937 ）

  • 血液透析を施行したCKD合併妊娠の一例

    中舎 璃乃, 上殿 英記, 森岡 史行, 曽根 一真, 仲谷 慎也, 津田 昌宏, 森 克仁, 北田 紘平, 長沼 俊秀, 武本 佳昭, 橘 大介, 繪本 正憲

    大阪透析研究会会誌   40 ( 2 )   172 - 173   2023.09（ ISSN:0912-6937 ）

  • 腎生検にて確定診断した糖尿病性腎症に対してLDLアフェレシス(LDL-A)療法を施行した一例

    好本 雅也, 仲谷 慎也, 森岡 史行, 渡邊 亘平, 古谷 真彦, 中舎 璃乃, 曽根 一真, 上殿 英記, 津田 昌宏, 森 克仁, 長沼 俊秀, 武本 佳昭, 繪本 正憲

    大阪透析研究会会誌   40 ( 2 )   177 - 177   2023.09（ ISSN:0912-6937 ）

  • 異なる腎病理を呈した骨髄増殖性腫瘍(MPN)の2症例

    田中 志歩, 上殿 英記, 中舎 璃乃, 仲谷 慎也, 津田 昌宏, 森 克仁, 繪本 正憲

    日本腎臓学会誌   65 ( 6-W )   801 - 801   2023.09（ ISSN:0385-2385 ）

  • 体外式膜型人工肺,CHDF,PEを併用した治療により致命的な肺胞出血から救命した顕微鏡的多発血管炎の一例

    古谷 真彦, 上殿 英記, 曽根 一真, 津田 昌宏, 仲谷 慎也, 長沼 俊秀, 森 克仁, 武本 佳昭, 溝端 康光, 繪本 正憲

    大阪透析研究会会誌   40 ( 2 )   168 - 168   2023.09（ ISSN:0912-6937 ）

  • ループス腎炎加療中の胃蜂窩織炎により死亡し病理解剖をおこなった一例

    高嶋 亮平, 曽根 一真, 上殿 英記, 野浦 郁恵, 田中 さやか, 仲谷 慎也, 津田 昌宏, 森 克仁, 繪本 正憲

    日本腎臓学会誌   65 ( 6-W )   764 - 764   2023.09（ ISSN:0385-2385 ）

  • MPO-ANCAと抗GBM抗体が同時陽性となったRPGNの3例

    小野 克宏, 小林 郁江, 岡崎 久宜, 乗峯 京子, 古谷 真彦, 仲谷 慎也, 森 克仁, 庄司 繁市, 繪本 正憲, 山川 智之

    日本腎臓学会誌   65 ( 6-W )   763 - 763   2023.09（ ISSN:0385-2385 ）

  • IgA腎症を合併したIgG4関連腎臓病の一例

    古谷 真彦, 仲谷 慎也, 高嶋 亮平, 森岡 史行, 曽根 一真, 上殿 英記, 福本 一夫, 津田 昌宏, 森 克仁, 橋本 求, 繪本 正憲

    日本腎臓学会誌   65 ( 6-W )   799 - 799   2023.09（ ISSN:0385-2385 ）

  • COVID-19感染後に抗糸球体基底膜抗体型腎炎を発症した一例

    森岡 史行, 津田 昌宏, 古谷 真彦, 中舎 璃乃, 曽根 一真, 上殿 英記, 仲谷 慎也, 森 克仁, 繪本 正憲

    大阪透析研究会会誌   40 ( 2 )   169 - 169   2023.09（ ISSN:0912-6937 ）

  • Serum phosphate as an independent factor associated with cholesterol metabolism in patients undergoing hemodialysis: a cross-sectional analysis of the DREAM cohort.

    Yujiro Okute, Tetsuo Shoji, Naoko Shimomura, Yoshihiro Tsujimoto, Yuki Nagata, Hideki Uedono, Shinya Nakatani, Tomoaki Morioka, Katsuhito Mori, Shinya Fukumoto, Yasuo Imanishi, Masanori Emoto

    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association   38 ( 4 )   1002 - 1008   2023.03（ ISSN:0931-0509 ） （ eISSN:1460-2385 ）

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    Publishing type：Research paper (scientific journal)   International / domestic magazine：International journal  

    BACKGROUND: Hyperphosphatemia is a risk factor for cardiovascular outcomes in patients with chronic kidney disease. In an experimental model, hyperphosphatemia promoted atherosclerosis by activating sterol regulatory element-binding protein 2, which controls cholesterol homeostasis. In the present study, we hypothesized that serum phosphate level is associated with cholesterol metabolism in patients with kidney failure. METHODS: We conducted a single-center cross-sectional study including 492 patients undergoing hemodialysis and 100 healthy controls not on statin or ezetimibe treatment. Serum lathosterol and campesterol levels were measured as a marker of cholesterol synthesis and absorption, respectively. As compared with the control group, the hemodialysis patients had higher median phosphate {5.8 mg/dL [interquartile range (IQR 5.0-6.6) versus 3.3 (3.0-3.6); P < .001], lower lathosterol [1.2 µg/mL (IQR 0.8-1.7) versus 2.6 (1.9-3.4); P < .001] and higher campesterol levels [4.5 µg/mL (IQR 3.6-6.0) versus 4.1 (3.2-5.4); P = .02]. Serum phosphate correlated positively to campesterol in the control group (Spearman's r = 0.21, P = .03) and in hemodialysis patients (Spearman's r = 0.19, P < .001). The positive association between phosphate and campesterol levels in the hemodialysis group remained significant in multivariable-adjusted linear regression analysis. There was no significant association between phosphate and lathosterol in either group. CONCLUSIONS: An independent association was found between phosphate and campesterol levels in patients with kidney failure. This study suggests a novel relationship between phosphate and cholesterol metabolism, both of which could affect cardiovascular outcomes in this population.

    DOI： 10.1093/ndt/gfac222

    PubMed

  • 【慢性腎臓病における血管石灰化の病態と治療】基礎と臨床の両面から　Fetuin-Aと血管石灰化

    森 克仁, 仲谷 慎也, 上殿 英記, 庄司 哲雄

    腎臓内科   17 ( 1 )   15 - 20   2023.01（ ISSN:2435-1903 ）

  • Design, Synthesis and Structure-Activity Relationship Studies of Protein Kinase CK2 Inhibitors Containing a Purine Scaffold.

    Nishiwaki K, Nakamura S, Yoshioka K, Nakagawa E, Nakatani S, Tsuyuguchi M, Kinoshita T, Nakanishi I

    Chemical & pharmaceutical bulletin   71 ( 7 )   558 - 565   2023（ ISSN:0009-2363 ）

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  • クローン病を伴う血清反応陰性フルハウス腎症(Seronegative Full-house Nephropathy with Crohn's Disease)

    Uedono Hideki, Tsuda Akihiro, Ueno Noriko, Natsuki Yuka, Nakaya Rino, Nishide Kozo, Machiba Yuri, Fujimoto Kenta, Nakatani Shinya, Mori Katsuhito, Emoto Masanori

    Internal Medicine   61 ( 23 )   3553 - 3558   2022.12（ ISSN:0918-2918 ）

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    症例は29歳女性で、19歳時にクローン病と診断され、メサラジンとサラゾスルファピリジンによる治療を行っていた。21歳時からアダリムマブ治療を行った。28歳時にはクローン病は寛解しており、皮膚症状はみられなかったが、徐々に足浮腫、蛋白尿、血尿が出現した。C3およびC4補体レベルは低くなく、血清クレアチニンは0.8mg/dLであった。腎生検を行い、光学顕微鏡検査では19の糸球体のうち五つで糸球体硬化症、一つで半月体形成性糸球体が判明し、糸球体の約3分の2でメサンギウム増殖と内皮下沈着を認めた。間質では、硬化糸球体周囲でリンパ球凝集が認められ、間質の約40%で線維症が観察された。免疫蛍光顕微鏡検査では、IgG、IgA、IgM、C1q、C3による糸球体係蹄メサンギウム領域の広範囲び漫性粒状染色を認めた。電子顕微鏡検査では、メサンギウム領域に電子沈着を認めた。フルハウス腎症と診断し、経口ステロイド治療を開始した。その結果、蛋白尿は改善した。

  • Associations of time-dependent changes in phosphorus levels with cardiovascular diseases in patients undergoing hemodialysis: results from the Japan Dialysis Active Vitamin D (J-DAVID) randomized clinical trial.

    Eri Koshi-Ito, Daijo Inaguma, Haruka Ishii, Yukio Yuzawa, Daijiro Kabata, Ayumi Shintani, Masaaki Inaba, Masanori Emoto, Katsuhito Mori, Tomoaki Morioka, Shinya Nakatani, Tetsuo Shoji

    Clinical kidney journal   15 ( 12 )   2281 - 2291   2022.12（ ISSN:2048-8505 ）

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    Publishing type：Research paper (scientific journal)   International / domestic magazine：International journal  

    BACKGROUND: While the risk of exceeding the standard range of phosphorus levels has been investigated, the impact of the degree of fluctuations has not been investigated. METHODS: Data were derived from the Japan Dialysis Active Vitamin D trial, a 4-year prospective, randomized study involving 976 patients without secondary hyperparathyroidism undergoing hemodialysis in Japan. Laboratory data were collected every 6 months and the primary outcome was the time to the occurrence of cardiovascular events. The effect of time-dependent changes in phosphorus levels was assessed using a time-varying Cox proportional hazards regression model. RESULTS: The median serum phosphorus levels at baseline and at the final observation were 4.70 mg/dl [interquartile range (IQR) 3.90-5.30] and 5.00 mg/dl (IQR 4.20-5.80), respectively. Over each 6-month period, phosphorus changes ranged from -7.1 to +6.7 mg/dl, with a median value of -0.1 to +0.3 mg/dl. During follow-up, composite cardiovascular events occurred in 103 of 964 patients. Although the P-value for the interaction between serum phosphorus level fluctuations and baseline phosphorus levels was insignificant, the following trends were observed. First, patients with relatively high initial phosphorus levels over a 6-month period showed a trend towards a higher hazard, with greater changes in the phosphorus level over the 6-month period. Second, it was suggested that oral vitamin D receptor activators could contribute to the relationship between fluctuating phosphorus levels and cardiovascular events. CONCLUSIONS: Our results suggest the importance of maintaining stable phosphorus levels, not only in the normal range, but also without fluctuations, in the risk of cardiovascular events among patients without secondary hyperparathyroidism undergoing maintenance hemodialysis.

    DOI： 10.1093/ckj/sfac172

    PubMed

  • JCS 2021 Guideline on the Clinical Application of Echocardiography.

    Ohte N, Ishizu T, Izumi C, Itoh H, Iwanaga S, Okura H, Otsuji Y, Sakata Y, Shibata T, Shinke T, Seo Y, Daimon M, Takeuchi M, Tanabe K, Nakatani S, Nii M, Nishigami K, Hozumi T, Yasukochi S, Yamada H, Yamamoto K, Izumo M, Inoue K, Iwano H, Okada A, Kataoka A, Kaji S, Kusunose K, Goda A, Takeda Y, Tanaka H, Dohi K, Hamaguchi H, Fukuta H, Yamada S, Watanabe N, Akaishi M, Akasaka T, Kimura T, Kosuge M, Masuyama T, Japanese Circulation Society Joint Working Group

    Circulation journal : official journal of the Japanese Circulation Society   86 ( 12 )   2045 - 2119   2022.11（ ISSN:1346-9843 ）

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  • Cystic Kidney Diseases That Require a Differential Diagnosis from Autosomal Dominant Polycystic Kidney Disease (ADPKD)

    Sekine Akinari, Hidaka Sumi, Moriyama Tomofumi, Shikida Yasuto, Shimazu Keiji, Ishikawa Eiji, Uchiyama Kiyotaka, Kataoka Hiroshi, Kawano Haruna, Kurashige Mahiro, Sato Mai, Suwabe Tatsuya, Nakatani Shinya, Otsuka Tadashi, Kai Hirayasu, Katayama Kan, Makabe Shiho, Manabe Shun, Shimabukuro Wataru, Nakanishi Koichi, Nishio Saori, Hattanda Fumihiko, Hanaoka Kazushige, Miura Kenichiro, Hayashi Hiroki, Hoshino Junichi, Tsuchiya Ken, Mochizuki Toshio, Horie Shigeo, Narita Ichiei, Muto Satoru

    Journal of Clinical Medicine   11 ( 21 )   1 - 25   2022.11（ ISSN:20770383 ） （ eISSN:20770383 ）

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    Autosomal dominant polycystic kidney disease (ADPKD) is the most common hereditary cystic kidney disease, with patients often having a positive family history that is characterized by a similar phenotype. However, in atypical cases, particularly those in which family history is unclear, a differential diagnosis between ADPKD and other cystic kidney diseases is important. When diagnosing ADPKD, cystic kidney diseases that can easily be excluded using clinical information include: multiple simple renal cysts, acquired cystic kidney disease (ACKD), multilocular renal cyst/multilocular cystic nephroma/polycystic nephroma, multicystic kidney/multicystic dysplastic kidney (MCDK), and unilateral renal cystic disease (URCD). However, there are other cystic kidney diseases that usually require genetic testing, or another means of supplementing clinical information to enable a differential diagnosis of ADPKD. These include autosomal recessive polycystic kidney disease (ARPKD), autosomal dominant tubulointerstitial kidney disease (ADTKD), nephronophthisis (NPH), oral-facial-digital (OFD) syndrome type 1, and neoplastic cystic kidney disease, such as tuberous sclerosis (TSC) and Von Hippel-Lindau (VHL) syndrome. To help physicians evaluate cystic kidney diseases, this article provides a review of cystic kidney diseases for which a differential diagnosis is required for ADPKD.

    CiNii Research

  • Cystic Kidney Diseases That Require a Differential Diagnosis from Autosomal Dominant Polycystic Kidney Disease (ADPKD).

    Akinari Sekine, Sumi Hidaka, Tomofumi Moriyama, Yasuto Shikida, Keiji Shimazu, Eiji Ishikawa, Kiyotaka Uchiyama, Hiroshi Kataoka, Haruna Kawano, Mahiro Kurashige, Mai Sato, Tatsuya Suwabe, Shinya Nakatani, Tadashi Otsuka, Hirayasu Kai, Kan Katayama, Shiho Makabe, Shun Manabe, Wataru Shimabukuro, Koichi Nakanishi, Saori Nishio, Fumihiko Hattanda, Kazushige Hanaoka, Kenichiro Miura, Hiroki Hayashi, Junichi Hoshino, Ken Tsuchiya, Toshio Mochizuki, Shigeo Horie, Ichiei Narita, Satoru Muto

    Journal of clinical medicine   11 ( 21 )   2022.11（ ISSN:2077-0383 ）

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    Publishing type：Research paper (scientific journal)   International / domestic magazine：International journal  

    Autosomal dominant polycystic kidney disease (ADPKD) is the most common hereditary cystic kidney disease, with patients often having a positive family history that is characterized by a similar phenotype. However, in atypical cases, particularly those in which family history is unclear, a differential diagnosis between ADPKD and other cystic kidney diseases is important. When diagnosing ADPKD, cystic kidney diseases that can easily be excluded using clinical information include: multiple simple renal cysts, acquired cystic kidney disease (ACKD), multilocular renal cyst/multilocular cystic nephroma/polycystic nephroma, multicystic kidney/multicystic dysplastic kidney (MCDK), and unilateral renal cystic disease (URCD). However, there are other cystic kidney diseases that usually require genetic testing, or another means of supplementing clinical information to enable a differential diagnosis of ADPKD. These include autosomal recessive polycystic kidney disease (ARPKD), autosomal dominant tubulointerstitial kidney disease (ADTKD), nephronophthisis (NPH), oral-facial-digital (OFD) syndrome type 1, and neoplastic cystic kidney disease, such as tuberous sclerosis (TSC) and Von Hippel-Lindau (VHL) syndrome. To help physicians evaluate cystic kidney diseases, this article provides a review of cystic kidney diseases for which a differential diagnosis is required for ADPKD.

    DOI： 10.3390/jcm11216528

    PubMed

  • COVID-19 mRNAワクチンmRNA-1273接種後の新規発症IgA血管炎に対して効果を示した代替ワクチンBNT162b2　1症例報告(Successful alternative vaccination with BNT162b2 mRNA COVID-19 vaccine for new-onset IgA vasculitis after receiving mRNA-1273-case report)

    Morioka Fumiyuki, Nakatani Shinya, Tsuda Akihiro, Mori Katsuhito, Emoto Masanori

    CEN Case Reports   11 ( 4 )   511 - 512   2022.11

  • Successful alternative vaccination with BNT162b2 mRNA COVID-19 vaccine for new-onset IgA vasculitis after receiving mRNA-1273-case report.

    Fumiyuki Morioka, Shinya Nakatani, Akihiro Tsuda, Katsuhito Mori, Masanori Emoto

    CEN case reports   11 ( 4 )   511 - 512   2022.11

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    International / domestic magazine：Domestic journal  

    DOI： 10.1007/s13730-022-00735-w

    PubMed

  • 特集 囊胞腎 【多発性囊胞腎(ADPKDとARPKD)の診断】 ADPKDの診断アルゴリズム

    仲谷 慎也

    腎と透析   93 ( 4 )   503 - 506   2022.10（ ISSN:03852156 ）

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  • Digenic変異に伴うX染色体連鎖型アルポート症候群の一例

    渡邊 亘平, 上殿 英記, 森岡 史行, 曽根 一真, 仲谷 慎也, 津田 昌宏, 森貞 直哉, 瀬戸 俊之, 森 克仁, 野津 寛大, 繪本 正憲

    日本腎臓学会誌   64 ( 6-W )   731 - 731   2022.10（ ISSN:0385-2385 ）

  • 超高齢者に免疫抑制療剤併用治療により完全寛解を得た膜性腎症再発の一症例

    西出 孝蔵, 上田 修子, 桑村 幸伸, 木村 和哉, 越智 正博, 垣谷 隆介, 仲谷 慎也, 津田 昌宏, 森 克仁, 石村 栄治, 繪本 正憲

    日本腎臓学会誌   64 ( 6-W )   753 - 753   2022.10（ ISSN:0385-2385 ）

  • 腎機能の保たれた糖尿病性腎症に対してLDLアフェレシス療法を施行した一例

    好本 雅也, 森岡 史行, 渡邊 亘平, 曽根 一真, 上殿 英記, 仲谷 慎也, 津田 昌宏, 長沼 俊秀, 武本 佳昭, 森 克仁, 繪本 正憲

    日本腎臓学会誌   64 ( 6-W )   741 - 741   2022.10（ ISSN:0385-2385 ）

  • 妊娠を契機に発症したネフローゼ症候群に対し多剤併用療法を行い分娩に至ったループス腎炎の一例

    待場 優里, 森 克仁, 中舎 璃乃, 森岡 史行, 上殿 英記, 渡部 龍, 仲谷 慎也, 津田 昌宏, 栗原 康, 橋本 求, 繪本 正憲

    日本腎臓学会誌   64 ( 6-W )   728 - 728   2022.10（ ISSN:0385-2385 ）

  • コルチコステロイド治療を受けた成人発症の微小変化型ネフローゼ症候群患者における完全寛解までの期間に関連した臨床的および病理組織学的特徴(Clinical and histopathological features related to time to complete remission in adult-onset minimal change nephrotic syndrome patients with corticosteroid treatment)

    Morioka Fumiyuki, Nakatani Shinya, Nishide Kozo, Machiba Yuri, Uedono Hideki, Tsuda Akihiro, Ishimura Eiji, Mori Katsuhito, Emoto Masanori

    Clinical and Experimental Nephrology   26 ( 10 )   955 - 962   2022.10（ ISSN:1342-1751 ）

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    生検で証明された成人発症の微小変化型ネフローゼ症候群(MCNS)患者を対象に、コルチコステロイド治療開始から完全寛解(CR)までの期間に関連した臨床的および病理組織学的要因を後方視的に検討した。CRは24時間尿蛋白<0.3g/日または尿蛋白/クレアチニン比<0.3g/gCrと定義した。2007年から2020年までに57例の患者(年齢22～63歳)をMCNSと診断した。CRまでの期間の中央値は11日(範囲8～21)であった。血清クレアチニン、尿蛋白に加えて、体重変化率もCRまでの期間と正の相関を示し(それぞれrs=0.438、p<0.001;rs=0.280、p=0.035;rs=0.544、p<0.001)、多変量Cox比例ハザードモデルにより、それらの因子はCRまでのより長い期間の有意な予測因子であることが示された。体重変化率の高いMCNS患者(28例)では、体重変化率の低い患者(29例)と比較して、血清クレアチニン、尿蛋白、病理組織学的スコアが有意に高く、CRまでの期間が有意に長かった。さらに、体重変化率の高いMCNS患者では、血清クレアチニンおよび尿蛋白で調整後、病理組織学的な間質性浮腫はCRまでの期間の長さと有意に関連していた。以上より、成人発症のMCNS患者において、体重変化率はCRまでの期間を予測できることが示唆された。

  • 【嚢胞腎】多発性嚢胞腎(ADPKDとARPKD)の診断　ADPKDの診断アルゴリズム

    仲谷 慎也

    腎と透析   93 ( 4 )   503 - 506   2022.10（ ISSN:0385-2156 ）

  • Effects of alfacalcidol on cardiovascular outcomes according to alkaline phosphatase levels in the J-DAVID trial.

    Tatsufumi Oka, Yusuke Sakaguchi, Yoshitaka Isaka, Haruka Ishii, Daijiro Kabata, Ayumi Shintani, Shinya Nakatani, Tomoaki Morioka, Katsuhito Mori, Masaaki Inaba, Masanori Emoto, Tetsuo Shoji

    Scientific reports   12 ( 1 )   15463 - 15463   2022.09

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    Publishing type：Research paper (scientific journal)   International / domestic magazine：International journal  

    In the Japan Dialysis Active Vitamin D (J-DAVID) trial, oral alfacalcidol numerically, but not significantly, increased the risk of cardiovascular events among patients undergoing hemodialysis. Because the cardiovascular effect of alfacalcidol could be modulated by bone turnover status, this post-hoc analysis of the J-DAVID examined how alkaline phosphatase (ALP), a more precise marker of bone turnover than parathyroid hormone (PTH), modifies the impact of alfacalcidol. The J-DAVID was a 48-month, open-label, randomized controlled trial comparing oral alfacalcidol with no vitamin D receptor activators use in terms of cardiovascular events among 976 hemodialysis patients without secondary hyperparathyroidism. This post-hoc analysis included 959 patients with available data on baseline ALP. The median [25-75th percentile] baseline ALP level was 234 [183-296] U/L. In a Cox proportional hazards model, ALP did not significantly modify the effect of alfacalcidol on the rate of cardiovascular events or all-cause death (P for effect modification = 0.54 and 0.74, respectively). The effect of alfacalcidol on time-series changes in calcium, phosphate, and intact PTH were similar across ALP subgroups. In conclusion, oral alfacalcidol did not significantly affect cardiovascular outcomes irrespective of bone turnover status.

    DOI： 10.1038/s41598-022-19820-2

    PubMed

  • 腎摘出後長期経過後に膜性腎症を発症し末期腎不全に至った腎移植ドナーの一例

    森岡 史行, 仲谷 慎也, 上殿 英記, 津田 昌宏, 山崎 健史, 長沼 俊秀, 森 克仁, 武本 佳昭, 内田 潤次, 繪本 正憲

    大阪透析研究会会誌   39 ( 2 )   229 - 229   2022.09（ ISSN:0912-6937 ）

  • mRNA-1273 COVID-19ワクチン接種後に新規発症した腎生検診断によるIgA血管炎　症例報告(New-onset kidney biopsy-proven IgA vasculitis after receiving mRNA-1273 COVID-19 vaccine: case report)

    Nakatani Shinya, Mori Katsuhito, Morioka Fumiyuki, Hirata Chika, Tsuda Akihiro, Uedono Hideki, Ishimura Eiji, Tsuruta Daisuke, Emoto Masanori

    CEN Case Reports   11 ( 3 )   358 - 362   2022.08

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    症例は47歳男性で、mRNA-1273 COVID-19ワクチン(モデルナ社)の初回接種から19日後、下肢および足背の紫斑性発疹のため来院した。発疹は5日以内に自然軽快したが、2回目のワクチン接種から15日後に再び出現した。皮膚生検の病理所見は白血球破砕性血管炎に類似していたが、免疫蛍光染色で微小血管壁にIgA沈着を認めなかった。尿検査では高度の蛋白尿および潜血を認めた。腎生検を行ったところ、光学顕微鏡観察で軽度のメサンギウム増殖、細胞増多、管内細胞増多に細胞性・線維細胞性半月体の形成を伴い、免疫蛍光染色ではメサンギウム領域でIgAが顆粒状に陽性を示し、IgA血管炎と一致する所見を認めた。メチルプレドニゾロン静脈内投与に続いてプレドニゾロン経口投与を行ったところ、2週間で血清クレアチニン値および蛋白尿は改善した。

  • 血液透析患者における血清インスリン様増殖因子1と新規心血管イベントおよびその後の死亡との関連　DREAMコホート(Associations of Serum Insulin-Like Growth Factor 1 with New Cardiovascular Events and Subsequent Death in Hemodialysis Patients: The DREAM Cohort)

    Nakaya Rino, Shoji Tetsuo, Nagata Yuki, Nakatani Shinya, Mori Katsuhito, Morioka Tomoaki, Tsujimoto Yoshihiro, Emoto Masanori

    Journal of Atherosclerosis and Thrombosis   29 ( 8 )   1153 - 1165   2022.08（ ISSN:1340-3478 ）

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    血液透析患者における血清インスリン様増殖因子1(IGF-1)濃度と、新規心血管イベントおよびその後の死亡との関連を検討した。維持血液透析患者に対して5年間経過観察を行った。ベースライン血清IGF-1値を測定し、516例(男性63%、年齢中央値61歳)をIGF-1値三分位でT1群175例、T2群170例、T3群171例に分けた。総死亡率、新規心血管疾患(CVD)イベント、CVDイベント後の死亡について評価した。全原因死亡が106例、新規CVDが190例で生じ、61例がその後に死亡した。169例が感染症によって入院し、47例がその後死亡した。全原因死亡のリスクはT1群で最も高く、この関連は多変量補正モデルでも有意であった。CVD転帰ではIGF-1は新規CVDイベントと関連しなかったが、補正モデルではその後の死亡と有意に関連していた。IGF-1は、感染症による入院の独立した予測因子ではなかったが、その後の死亡を予測した。

  • Possible role of insulin resistance in activation of plasma xanthine oxidoreductase in health check-up examinees. Reviewed

    Kurajoh M, Fukumoto S, Akari S, Murase T, Nakamura T, Takahashi K, Yoshida H, Nakatani S, Tsuda A, Morioka T, Mori K, Imanishi Y, Hirata K, Emoto M

    Scientific reports   12 ( 1 )   10281   2022.06

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  • Clinical and histopathological features related to time to complete remission in adult-onset minimal change nephrotic syndrome patients with corticosteroid treatment. Reviewed OA

    Morioka F, Nakatani S, Nishide K, Machiba Y, Uedono H, Tsuda A, Ishimura E, Mori K, Emoto M

    Clinical and experimental nephrology   2022.05（ ISSN:1342-1751 ）

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    Authorship：Corresponding author  

    DOI： 10.1007/s10157-022-02235-8

    PubMed

    Repository URL： http://hdl.handle.net/10466/0002000410

  • A Case of Seronegative Full-house Nephropathy with Crohn's Disease

    Uedono Hideki, Tsuda Akihiro, Ueno Noriko, Natsuki Yuka, Nakaya Rino, Nishide Kozo, Machiba Yuri, Fujimoto Kenta, Nakatani Shinya, Mori Katsuhito, Emoto Masanori

    Internal Medicine   advpub ( 0 )   2022.05（ ISSN:0918-2918 ） （ eISSN:13497235 ）

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  • 非小細胞肺癌の化学療法後に血栓性微小血管障害症(TMA)を発症し血漿交換(PE)が奏功した1例

    森岡 史行, 津田 昌宏, 重里 樹里, 上殿 英記, 仲谷 慎也, 黒木 慶和, 長沼 俊秀, 森 克仁, 武本 佳昭, 内田 潤次, 繪本 正憲

    日本透析医学会雑誌   55 ( Suppl.1 )   566 - 566   2022.05（ ISSN:1340-3451 ）

  • 血液透析患者におけるgeriatric nutritional risk index(GNRI)による栄養評価と感染症入院後の総死亡との関連

    待場 優里, 森 克仁, 庄司 哲雄, 上殿 英記, 仲谷 慎也, 津田 昌宏, 吉田 寿子, 辻本 吉広, 繪本 正憲

    日本透析医学会雑誌   55 ( Suppl.1 )   545 - 545   2022.05（ ISSN:1340-3451 ） （ eISSN:1883-082X ）

  • 特集 ネフローゼ症候群update 【合併症と対策】 脂質異常症･耐糖能異常

    仲谷 慎也, 庄司 哲雄

    腎と透析   92 ( 4 )   760 - 764   2022.04（ ISSN:03852156 ）

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  • Effects of ipragliflozin on left ventricular diastolic function in patients with type 2 diabetes and heart failure with preserved ejection fraction: The EXCEED randomized controlled multicenter study

    Akasaka H.

    Geriatrics and Gerontology International   22 ( 4 )   298 - 304   2022.04（ ISSN:14441586 ）

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  • Nutritional Disorder Evaluated by the Geriatric Nutritional Risk Index Predicts Death After Hospitalization for Infection in Patients Undergoing Maintenance Hemodialysis.

    Machiba Y, Mori K, Shoji T, Nagata Y, Uedono H, Nakatani S, Ochi A, Tsuda A, Morioka T, Yoshida H, Tsujimoto Y, Emoto M

    Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation   2022.02（ ISSN:1051-2276 ）

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  • New-onset kidney biopsy-proven IgA vasculitis after receiving mRNA-1273 COVID-19 vaccine: case report.

    Nakatani S, Mori K, Morioka F, Hirata C, Tsuda A, Uedono H, Ishimura E, Tsuruta D, Emoto M

    CEN case reports   2022.01

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  • Association between Levocarnitine Treatment and the Change in Knee Extensor Strength in Patients Undergoing Hemodialysis: A Post-Hoc Analysis of the Osaka Dialysis Complication Study (ODCS).

    Matsufuji S, Shoji T, Lee S, Yamaguchi M, Nishimura M, Tsujimoto Y, Nakatani S, Morioka T, Mori K, Emoto M

    Nutrients   14 ( 2 )   2022.01

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  • Significant Association of Diabetes With Mortality of Chronic Hemodialysis Patients, Independent of the Presence of Obesity, Sarcopenia, and Sarcopenic Obesity.

    Ishimura E, Okuno S, Nakatani S, Mori K, Miyawaki J, Okazaki H, Sugie N, Norimine K, Yamakawa K, Tsujimoto Y, Shoji S, Inaba M, Yamakawa T, Emoto M

    Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation   32 ( 1 )   94 - 101   2022.01（ ISSN:1051-2276 ）

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  • 血液透析患者におけるGNRIによる栄養評価と感染症入院後の予後との関連

    待場 優里, 森 克仁, 庄司 哲雄, 上殿 英記, 仲谷 慎也, 津田 昌宏, 森岡 与明, 吉田 寿子, 辻本 吉広, 繪本 正憲

    日本病態栄養学会誌   24-25 ( Suppl. )   S - 62   2022.01（ ISSN:1345-8167 ）

  • Fibroblast Growth Factor 23 as Regulator of Vitamin D Metabolism.

    Nakatani S, Nakatani A, Mori K, Emoto M, Inaba M, Razzaque MS

    Advances in experimental medicine and biology   1362   47 - 54   2022（ ISSN:0065-2598 ）

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  • Dialysate calcium, alfacalcidol, and clinical outcomes: A post-hoc analysis of the J-DAVID trial.

    Kunitoshi Iseki, Daijiro Kabata, Tetsuo Shoji, Masaaki Inaba, Masanori Emoto, Katsuhito Mori, Tomoaki Morioka, Shinya Nakatani, Ayumi Shintani

    PloS one   17 ( 9 )   e0273195   2022

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    Publishing type：Research paper (scientific journal)   International / domestic magazine：International journal  

    The selection of dialysate calcium concentration (D-Ca) is still controversial among chronic hemodialysis (HD) regimens. We examined the trajectories of CKD MBD parameters among the J-DAVID trial participants to see the effect of D-Ca and alfacalcidol. The trial was an open-label randomized clinical trial including 976 HD patients with intact PTH of 180 pg/mL or lower which compared the users of vitamin D receptor activator (oral alfacalcidol) and non-users over a median of 4 years. The main D-Ca used at baseline were 3.0 mEq/L in 70% and 2.5 mEq/L in 25%, respectively. The primary endpoint was the composite of fatal and non-fatal cardiovascular events and the secondary endpoint was all-cause mortality. Multivariable Cox proportional hazard regression analyses in which D-Ca was included as a possible effect modifier and serum laboratory data as time-varying covariates showed no significant effect modification for composite cardiovascular events or all-cause mortality. This post hoc analysis showed that the effects of alfacalcidol on cardiovascular outcomes were not significantly modified by D-Ca.

    DOI： 10.1371/journal.pone.0273195

    PubMed

  • Factors associated with endoscopic treatment decisions for T1b or more deeply invading colorectal cancers(和訳中)

    Nakatani Shinya, Katagiri Atsushi, Suzuki Norihiro, Kikuchi Kazuo, Yanagisawa Fumito, Gocho Toshihiko, Inoki Kazuya, Konda Kenichi, Yamamura Fuyuhiko, Inoue Eisuke, Yoshida Hitoshi

    The Showa University Journal of Medical Sciences   33 ( 4 )   133 - 142   2021.12（ ISSN:0915-6380 ）

  • A digest from evidence-based Clinical Practice Guideline for Polycystic Kidney Disease 2020.

    Nishio S, Tsuchiya K, Nakatani S, Muto S, Mochizuki T, Kawano H, Hanaoka K, Hidaka S, Ichikawa D, Ishikawa E, Uchiyama K, Koshi-Ito E, Hayashi H, Makabe S, Ogata S, Mitobe M, Sekine A, Suwabe T, Kataoka H, Kai H, Kaneko Y, Kurashige M, Seta K, Shimazu K, Hama T, Miura K, Nakanishi K, Horie S, Furuichi K, Okada H, Narita I, Committee of Clinical Practical Guideline for Polycystic Kidney Disease 2020.

    Clinical and experimental nephrology   25 ( 12 )   1292 - 1302   2021.12（ ISSN:1342-1751 ）

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  • Dissociation of Glycated Albumin and HbA<sub>1c</sub> Is Associated With a Decline of Glomerular Filtration Rate as Evaluated by Inulin Clearance.

    Tsuda A, Mori K, Nakatani S, Machiba Y, Uedono H, Kurajoh M, Yamada S, Morioka T, Inaba M, Ishimura E, Uchida J, Emoto M

    Diabetes care   44 ( 11 )   e188 - e189   2021.11（ ISSN:0149-5992 ）

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  • Low Free Triiodothyronine Level as a Predictor of Cardiovascular Events and All-Cause Mortality in Patients Undergoing Hemodialysis: The DREAM Cohort

    Yamazaki Yuko, Shoji Tetsuo, Miyashima Masako, Nagata Yuki, Kakutani Yoshinori, Ochi Akinobu, Morioka Tomoaki, Nakatani Shinya, Mori Katsuhito, Tsujimoto Yoshihiro, Emoto Masanori

    Journal of Atherosclerosis and Thrombosis   28 ( 10 )   1071 - 1082   2021.10（ ISSN:1340-3478 ） （ eISSN:18803873 ）

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    <p><b>Aim:</b> Low T3 syndrome is characterized by low serum triiodothyronine (T3) levels without elevation of thyroid-stimulating hormone (TSH) in patients without apparent thyroid disease, which is known to be associated with worse clinical outcomes in various populations including those with kidney failure. In this study, we examined whether low free T3 (FT3) levels are independent predictor of cardiovascular disease (CVD) events in patients undergoing hemodialysis. </p><p><b>Methods:</b> This was a prospective cohort study of patients with chronic kidney disease undergoing hemodialysis. From the total of 518 patients, we excluded patients with treated or untreated hyperthyroidism or hypothyroidism and those treated with corticosteroids. </p><p><b>Results:</b> We analyzed data from 438 eligible patients. During the 5-year follow-up, 154 new CVD events and 86 all-cause deaths were recorded. Kaplan-Meier analysis showed that lower FT3 levels were associated with higher risks for new cardiovascular events and all-cause death. This inverse association of FT3 and new CVD events remained significant after adjustment for age, sex, duration of hemodialysis, diabetic kidney disease, hypertension, dyslipidemia, and smoking; however, it was no longer significant after further adjustment for prior CVD or N-terminal fragment of probrain natriuretic peptide (NT-proBNP). FT3 did not show an independent association with all-cause mortality. </p><p><b>Conclusions:</b> Our results indicate that low FT3 status is not an independent predictor of new CVD events and that the following factors are closely associated: prior CVD, low FT3 and high NT-proBNP levels at present, and future risk of new CVD events in hemodialysis patients. </p>

    DOI： 10.5551/jat.60624

    PubMed

    CiNii Research

  • 血液透析中の患者における心血管イベントと総死亡率の予測因子としての遊離トリヨードチロニン低値　DREAMコホート(Low Free Triiodothyronine Level as a Predictor of Cardiovascular Events and All-Cause Mortality in Patients Undergoing Hemodialysis: The DREAM Cohort)

    Yamazaki Yuko, Shoji Tetsuo, Miyashima Masako, Nagata Yuki, Kakutani Yoshinori, Ochi Akinobu, Morioka Tomoaki, Nakatani Shinya, Mori Katsuhito, Tsujimoto Yoshihiro, Emoto Masanori

    Journal of Atherosclerosis and Thrombosis   28 ( 10 )   1071 - 1082   2021.10（ ISSN:1340-3478 ）

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    遊離トリヨードチロニン(FT3)低値が血液透析中の患者における心血管疾患イベントの独立予測因子であるかどうかを調べた。血液透析中の慢性腎疾患患者を対象に、血清FT3、遊離チロキシン、甲状腺刺激ホルモン値を測定した。5年間の経過観察を行い、心血管疾患の新規発症、死亡日と死亡原因を評価した。438例をFT3値の三分位で最低FT3群171例(男性56.7%、中央値63歳)、中等度FT3群103例(男性68.0%、中央値63歳)、最高FT3群164例(男性68.3%、中央値57歳)に分けた。経過観察期間中、154例が新規に心血管疾患を発症し、86例があらゆる原因で死亡した。Kaplan-Meier分析では低FT3値が新規心血管イベントとあらゆる原因による死亡に対する抗リスクと関連した。FT3と新規心血管疾患イベントの逆相関は、年齢、性別、血液透析期間、糖尿病性腎症、高血圧、脂質異常症、喫煙の補正後も有意であったが、以前の心血管疾患、N末端プロ脳性ナトリウム利尿ペプチドの補正後では有意ではなかった。FT3は総死亡率と独立に関連しなかった。

  • Associations of Serum Insulin-Like Growth Factor 1 with New Cardiovascular Events and Subsequent Death in Hemodialysis Patients: The DREAM Cohort.

    Nakaya R, Shoji T, Nagata Y, Nakatani S, Mori K, Morioka T, Tsujimoto Y, Emoto M

    Journal of atherosclerosis and thrombosis   2021.09（ ISSN:1340-3478 ）

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  • Factors predicting decline in renal function and kidney volume growth in autosomal dominant polycystic kidney disease: a prospective cohort study (Japanese Polycystic Kidney Disease registry: J-PKD).

    Uchiyama K, Mochizuki T, Shimada Y, Nishio S, Kataoka H, Mitobe M, Tsuchiya K, Hanaoka K, Ubara Y, Suwabe T, Sekine A, Nutahara K, Tsuruya K, Ishimura E, Nakatani S, Sofue T, Tanaka S, Narita I, Maruyama S, Horie S, Muto S

    Clinical and experimental nephrology   25 ( 9 )   970 - 980   2021.09（ ISSN:1342-1751 ）

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  • Factors predicting decline in renal function and kidney volume growth in autosomal dominant polycystic kidney disease: a prospective chort study(Japanese Polycystic Kidney Disease registry:J-PKD)(和訳中)

    Uchiyama Kiyotaka, Mochizuki Toshio, Shimada Yosuke, Nishio Saori, Kataoka Hiroshi, Mitobe Michihiro, Tsuchiya Ken, Hanaoka Kazushige, Ubara Yoshifumi, Suwabe Tatsuya, Sekine Akinari, Nutahara Kikuo, Tsuruya Kazuhiko, Ishimura Eiji, Nakatani Shinya, Sofue Tadashi, Tanaka Satoshi, Narita Ichiei, Maruyama Shoichi, Horie Shigeo, Muto Satoru

    Clinical and Experimental Nephrology   25 ( 9 )   970 - 980   2021.09（ ISSN:1342-1751 ）

  • Associations of cardiovascular disease and blood pressure with cognition in hemodialysis patients: The Osaka Dialysis Complication Study.

    Shoji T, Fujii H, Mori K, Nakatani S, Nagata Y, Morioka T, Inaba M, Emoto M

    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association   2021.08（ ISSN:0931-0509 ）

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  • Association of Zinc Deficiency with Development of CVD Events in Patients with CKD.

    Nakatani S, Mori K, Shoji T, Emoto M

    Nutrients   13 ( 5 )   2021.05

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  • Cinacalcet may suppress kidney enlargement in hemodialysis patients with autosomal dominant polycystic kidney disease.

    Nakatani S, Nishide K, Okuno S, Ishimura E, Kabata D, Morioka F, Machiba Y, Uedono H, Tsuda A, Shoji S, Inaba M, Mori K, Yamakawa T, Emoto M

    Scientific reports   11 ( 1 )   10014   2021.05

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  • Comparative Effects of Etelcalcetide and Maxacalcitol on Serum Calcification Propensity in Secondary Hyperparathyroidism: A Randomized Clinical Trial. Reviewed

    Shoji T, Nakatani S, Kabata D, Mori K, Shintani A, Yoshida H, Takahashi K, Ota K, Fujii H, Ueda S, Nishi S, Nakatani T, Yoshiyama M, Goto K, Hamada T, Imanishi M, Ishimura E, Kagitani S, Kato Y, Kumeda Y, Maekawa K, Matsumura T, Nagayama H, Obi Y, Ohno Y, Sai Y, Sakurai M, Sasaki S, Shidara K, Shoji S, Tsujimoto Y, Yamakawa K, Yasuda H, Yodoi S, Inaba M, Emoto M

    Clinical journal of the American Society of Nephrology : CJASN   16 ( 4 )   599 - 612   2021.04（ ISSN:1555-9041 ）

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.2215/CJN.16601020

    PubMed

  • Comparative Effects of Etelcalcetide and Maxacalcitol on Serum Calcification Propensity in Secondary Hyperparathyroidism: A Randomized Clinical Trial.

    Shoji T, Nakatani S, Kabata D, Mori K, Shintani A, Yoshida H, Takahashi K, Ota K, Fujii H, Ueda S, Nishi S, Nakatani T, Yoshiyama M, Goto K, Hamada T, Imanishi M, Ishimura E, Kagitani S, Kato Y, Kumeda Y, Maekawa K, Matsumura T, Nagayama H, Obi Y, Ohno Y, Sai Y, Sakurai M, Sasaki S, Shidara K, Shoji S, Tsujimoto Y, Yamakawa K, Yasuda H, Yodoi S, Inaba M, Emoto M

    Clinical journal of the American Society of Nephrology : CJASN   16 ( 4 )   599 - 612   2021.04（ ISSN:1555-9041 ）

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  • Effects of fetuin-A-containing calciprotein particles on posttranslational modifications of fetuin-A in HepG2 cells. Reviewed

    Uedono H, Mori K, Ochi A, Nakatani S, Miki Y, Tsuda A, Morioka T, Nagata Y, Imanishi Y, Shoji T, Inaba M, Emoto M

    Scientific reports   11 ( 1 )   7486   2021.04

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.1038/s41598-021-86881-0

    PubMed

  • Effects of fetuin-A-containing calciprotein particles on posttranslational modifications of fetuin-A in HepG2 cells.

    Uedono H, Mori K, Ochi A, Nakatani S, Miki Y, Tsuda A, Morioka T, Nagata Y, Imanishi Y, Shoji T, Inaba M, Emoto M

    Scientific reports   11 ( 1 )   7486   2021.04

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  • Plasma xanthine oxidoreductase activity change over 12 months independently associated with change in serum uric acid level: MedCity21 health examination registry.

    Kurajoh M, Fukumoto S, Murase T, Nakamura T, Nagata Y, Nakatani S, Tsuda A, Yamada S, Morioka T, Mori K, Imanishi Y, Kawada N, Hirata K, Emoto M

    Clinical chemistry and laboratory medicine   59 ( 4 )   e137 - e140   2021.03（ ISSN:1434-6621 ）

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  • Suppression of thyrotropin secretion during roxadustat treatment for renal anemia in a patient undergoing hemodialysis Reviewed

    Ichii Mitsuru, Mori Katsuhito, Miyaoka Daichi, Sonoda Mika, Tsujimoto Yoshihiro, Nakatani Shinya, Shoji Tetsuo, Emoto Masanori

    BMC NEPHROLOGY   22 ( 1 )   104   2021.03

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.1186/s12882-021-02304-2

    PubMed

  • Suppression of thyrotropin secretion during roxadustat treatment for renal anemia in a patient undergoing hemodialysis.

    Ichii M, Mori K, Miyaoka D, Sonoda M, Tsujimoto Y, Nakatani S, Shoji T, Emoto M

    BMC nephrology   22 ( 1 )   104   2021.03

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  • Oxidative Stress and Inflammation as Predictors of Mortality and Cardiovascular Events in Hemodialysis Patients: The DREAM Cohort

    Sasaki Keyaki, Shoji Tetsuo, Kabata Daijiro, Shintani Ayumi, Okute Yujiro, Tsuchikura Shoko, Shimomura Naoko, Tsujimoto Yoshihiro, Nakatani Shinya, Mori Katsuhito, Shioi Atsushi, Inaba Masaaki, Emoto Masanori

    Journal of Atherosclerosis and Thrombosis   28 ( 3 )   249 - 260   2021.03（ ISSN:1340-3478 ） （ eISSN:18803873 ）

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    <p><b>Aim:</b> Both oxidative stress and inflammation are involved in the pathogenesis of cardiovascular disease (CVD). The serum level of derivatives of reactive oxygen metabolites (d-ROMs) is a measure of the total amount of hydroperoxides serving as a marker of oxidative stress. We investigated whether d-ROMs could predict the clinical outcomes in hemodialysis patients and whether the associations of d-ROMs with the outcomes are independent of a marker of inflammation, C-reactive protein (CRP). </p><p><b>Methods:</b> This was a prospective cohort study in hemodialysis patients. The key exposures were the serum levels of d-ROMs and CRP. The outcome measures were all-cause mortality and new CVD events. </p><p><b>Results:</b> A total of 517 patients were analyzed. d-ROMs correlated positively with CRP. During follow-up for 5 years, 107 patients died, and 190 patients experienced new CVD events. In the Kaplan–Meier analyses, both higher d-ROMs and higher CRP levels predicted higher risks for mortality and CVD events. By Cox proportional-hazard regression analysis adjusted for potential confounders excluding CRP, d-ROMs exhibited a significant association with all-cause mortality, but this association was no longer significant after further adjustment for CRP. Using the same model, CRP exhibited a significant association with all-cause mortality, but this association was no longer significant after further adjustment for d-ROMs. When we analyzed new CVD events as the outcome, CRP was a significant predictor, whereas the level of d-ROMs was not. </p><p><b>Conclusions:</b> Although d-ROMs predicted mortality and CVD events in unadjusted models, the associations of d-ROMs with these outcomes were not independent of CRP. Oxidative stress and inflammation appear to share common causal pathways. </p>

    DOI： 10.5551/jat.56069

    PubMed

    CiNii Research

  • Clinical and histopathological features of acute kidney injury in adult-onset minimal change nephrotic syndrome Reviewed

    Nishide Kozo, Nakatani Shinya, Mori Katsuhito, Morioka Fumiyuki, Machiba Yuri, Uedono Hideki, Tsuda Akihiro, Inaba Masaaki, Ishimura Eiji, Emoto Masanori

    CLINICAL AND EXPERIMENTAL NEPHROLOGY   25 ( 3 )   261 - 269   2021.03（ ISSN:1342-1751 ）

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.1007/s10157-020-01992-8

    PubMed

  • Plasma xanthine oxidoreductase activity change over 12 months independently associated with change in serum uric acid level: MedCity21 health examination registry Reviewed

    Kurajoh Masafumi, Fukumoto Shinya, Murase Takayo, Nakamura Takashi, Nagata Yuki, Nakatani Shinya, Tsuda Akihiro, Yamada Shinsuke, Morioka Tomoaki, Mori Katsuhito, Imanishi Yasuo, Kawada Norifumi, Hirata Kazuto, Emoto Masanori

    CLINICAL CHEMISTRY AND LABORATORY MEDICINE   59 ( 4 )   E137 - E140   2021.03（ ISSN:1434-6621 ）

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.1515/cclm-2020-0563

    PubMed

  • 血液透析患者の死亡率および心血管イベントの予測因子としての酸化ストレスと炎症　DREAMコホート(Oxidative Stress and Inflammation as Predictors of Mortality and Cardiovascular Events in Hemodialysis Patients: The DREAM Cohort)

    Sasaki Keyaki, Shoji Tetsuo, Kabata Daijiro, Shintani Ayumi, Okute Yujiro, Tsuchikura Shoko, Shimomura Naoko, Tsujimoto Yoshihiro, Nakatani Shinya, Mori Katsuhito, Shioi Atsushi, Inaba Masaaki, Emoto Masanori

    Journal of Atherosclerosis and Thrombosis   28 ( 3 )   249 - 260   2021.03（ ISSN:1340-3478 ）

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    derivative of reactive oxygen metabolite(d-ROM)から血液透析患者の臨床成績を予測できるかどうか、d-ROMと臨床成績との関連がC反応性蛋白質(CRP)に非依存的かどうかを調べた。血液透析患者から血液検体を採取して、d-ROMアッセイを実施した。総死亡率と新規心血管疾患(CVD)イベントを評価した。血液透析患者517例(男性62.9%、中央値61歳)を解析した。d-ROMはCRPと正に関連した。5年間の経過観察期間中、107例が死亡し、190例が新規CVDイベントを経験した。Kaplan-Meier解析では高d-ROMと高CRPは死亡率とCVDイベントの高リスクを予測した。CRP以外の潜在的交絡因子を補正したコックス比例ハザード回帰分析では、d-ROMsは総死亡率と有意に関連したが、CRPを補正するとこの関連は有意ではなくなった。同じモデルでCRPは総死亡率と有意な関連を示したが、d-ROMsを補正するとこの関連は有意ではなくなった。新規CVDイベントを転帰として分析するとCRPは有意な予測因子であったが、d-ROMは有意な予測因子ではなかった。

  • 成人発症微小変化型ネフローゼ症候群における急性腎障害の臨床的および病理組織学的特徴(Clinical and histopathological features of acute kidney injury in adult-onset minimal change nephrotic syndrome)

    Nishide Kozo, Nakatani Shinya, Mori Katsuhito, Morioka Fumiyuki, Machiba Yuri, Uedono Hideki, Tsuda Akihiro, Inaba Masaaki, Ishimura Eiji, Emoto Masanori

    Clinical and Experimental Nephrology   25 ( 3 )   261 - 269   2021.03（ ISSN:1342-1751 ）

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    成人発症微小変化型ネフローゼ症候群(MCNS)患者において、Kidney Disease Improving Global Outcomes分類による急性腎障害(AKI)発症を予測するために、臨床的および病理組織学的特徴を調べた。コルチコステロイド投与を受け、生検で確認された成人発症MCNS患者58名(男性38名、女性20名、年齢中央値49歳)を対象に、後ろ向き研究を行った。その結果、24名(41.4%)はAKIを合併していた。AKI合併患者は、AKIを合併していない患者に比べて、年齢、尿蛋白、体重増加(入院から退院までの差)、病理組織学的スコアが有意に高かった。尿蛋白、体重増加、間質性浮腫スコアはAKI発症といずれも有意に関連していた。AKIを発症した24名のうち10名は一時的に血液透析治療を受けた。病理組織学的特徴に違いはなかったが、血液透析を要したAKIを合併した患者では、血液透析を要しなかった患者に比べて、発症から腎生検までの期間が有意に長くなった(32[24〜46]日対13[10〜23]日、p=0.034)。これらの結果から、尿蛋白、体重増加、間質性浮腫スコアが、成人発症MCNS患者のAKI発症を予測するために重要であることが示された。

  • Clinical and histopathological features of acute kidney injury in adult-onset minimal change nephrotic syndrome.

    Nishide K, Nakatani S, Mori K, Morioka F, Machiba Y, Uedono H, Tsuda A, Inaba M, Ishimura E, Emoto M

    Clinical and experimental nephrology   25 ( 3 )   261 - 269   2021.03（ ISSN:1342-1751 ）

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  • Oxidative Stress and Inflammation as Predictors of Mortality and Cardiovascular Events in Hemodialysis Patients: The DREAM Cohort Reviewed

    Sasaki Keyaki, Shoji Tetsuo, Kabata Daijiro, Shintani Ayumi, Okute Yujiro, Tsuchikura Shoko, Shimomura Naoko, Tsujimoto Yoshihiro, Nakatani Shinya, Mori Katsuhito, Shioi Atsushi, Inaba Masaaki, Emoto Masanori

    一般社団法人 日本動脈硬化学会　JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS   28 ( 3 )   249 - 260   2021（ ISSN:1340-3478 ）

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    Publishing type：Research paper (scientific journal)  

    <p><b>Aim:</b> Both oxidative stress and inflammation are involved in the pathogenesis of cardiovascular disease (CVD). The serum level of derivatives of reactive oxygen metabolites (d-ROMs) is a measure of the total amount of hydroperoxides serving as a marker of oxidative stress. We investigated whether d-ROMs could predict the clinical outcomes in hemodialysis patients and whether the associations of d-ROMs with the outcomes are independent of a marker of inflammation, C-reactive protein (CRP). </p><p><b>Methods:</b> This was a prospective cohort study in hemodialysis patients. The key exposures were the serum levels of d-ROMs and CRP. The outcome measures were all-cause mortality and new CVD events. </p><p><b>Results:</b> A total of 517 patients were analyzed. d-ROMs correlated positively with CRP. During follow-up for 5 years, 107 patients died, and 190 patients experienced new CVD events. In the Kaplan–Meier analyses, both higher d-ROMs and higher CRP levels predicted higher risks for mortality and CVD events. By Cox proportional-hazard regression analysis adjusted for potential confounders excluding CRP, d-ROMs exhibited a significant association with all-cause mortality, but this association was no longer significant after further adjustment for CRP. Using the same model, CRP exhibited a significant association with all-cause mortality, but this association was no longer significant after further adjustment for d-ROMs. When we analyzed new CVD events as the outcome, CRP was a significant predictor, whereas the level of d-ROMs was not. </p><p><b>Conclusions:</b> Although d-ROMs predicted mortality and CVD events in unadjusted models, the associations of d-ROMs with these outcomes were not independent of CRP. Oxidative stress and inflammation appear to share common causal pathways. </p>

    DOI： 10.5551/jat.56069

    PubMed

    CiNii Research

  • Plasma Xanthine Oxidoreductase Activity Associated with Glycemic Control in Patients with Pre-Dialysis Chronic Kidney Disease.

    Nakatani S, Ishimura E, Murase T, Nakamura T, Nakatani A, Toi N, Nishide K, Uedono H, Tsuda A, Kurajoh M, Yamada S, Mori K, Inaba M, Emoto M

    Kidney & blood pressure research   46 ( 4 )   475 - 483   2021（ ISSN:1420-4096 ）

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  • Demographic, clinical characteristics and treatment outcomes of immune-complex membranoproliferative glomerulonephritis and C3 glomerulonephritis in Japan: A retrospective analysis of data from the Japan Renal Biopsy Registry.

    Nakagawa N, Mizuno M, Kato S, Maruyama S, Sato H, Nakaya I, Sugiyama H, Fujimoto S, Miura K, Matsumura C, Gotoh Y, Suzuki H, Kuroki A, Yoshino A, Nakatani S, Hiromura K, Yamamoto R, Yokoyama H, Narita I, Isaka Y

    PloS one   16 ( 9 )   e0257397   2021

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  • Low Free Triiodothyronine Level as a Predictor of Cardiovascular Events and All-Cause Mortality in Patients Undergoing Hemodialysis: The DREAM Cohort. Reviewed

    Yamazaki Y, Shoji T, Miyashima M, Nagata Y, Kakutani Y, Ochi A, Morioka T, Nakatani S, Mori K, Tsujimoto Y, Emoto M

    一般社団法人 日本動脈硬化学会　Journal of atherosclerosis and thrombosis   2020.12（ ISSN:1340-3478 ）

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    Publishing type：Research paper (scientific journal)  

    <p><b>Aim: </b>Low T3 syndrome is characterized by low serum triiodothyronine (T3) levels without elevation of thyroid-stimulating hormone (TSH) in patients without apparent thyroid disease, which is known to be associated with worse clinical outcomes in various populations including those with kidney failure. In this study, we examined whether low free T3 (FT3) levels are independent predictor of cardiovascular disease (CVD) events in patients undergoing hemodialysis.<b> </b></p><p><b>Methods: </b>This was a prospective cohort study of patients with chronic kidney disease undergoing hemodialysis. From the total of 518 patients, we excluded patients with treated or untreated hyperthyroidism or hypothyroidism and those treated with corticosteroids.</p><p><b>Results:</b> We analyzed data from 438 eligible patients. During the 5-year follow-up, 154 new CVD events and 86 all-cause deaths were recorded. Kaplan-Meier analysis showed that lower FT3 levels were associated with higher risks for new cardiovascular events and all-cause death. This inverse association of FT3 and new CVD events remained significant after adjustment for age, sex, duration of hemodialysis, diabetic kidney disease, hypertension, dyslipidemia, and smoking; however, it was no longer significant after further adjustment for prior CVD or N-terminal fragment of probrain natriuretic peptide (NT-proBNP). FT3 did not show an independent association with all-cause mortality.<b> </b></p><p><b>Conclusions: </b>Our results indicate that low FT3 status is not an independent predictor of new CVD events and that the following factors are closely associated: prior CVD, low FT3 and high NT-proBNP levels at present, and future risk of new CVD events in hemodialysis patients.</p>

    DOI： 10.5551/jat.60624

    PubMed

    CiNii Research

  • Increased Glomerular Hydrostatic Pressure is Associated with Tubular Creatinine Reabsorption in Healthy Subjects Reviewed

    Tsuda Akihiro, Ishimura Eiji, Machiba Yuri, Uedono Hideki, Nakatani Shinya, Mori Katsuhito, Uchida Junji, Emoto Masanori

    KIDNEY & BLOOD PRESSURE RESEARCH   45 ( 6 )   996 - 1008   2020.12（ ISSN:1420-4096 ）

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.1159/000510838

    PubMed

  • Review of the efforts of the Japanese Society of Echocardiography for coronavirus disease 2019 (COVID-19) during the initial outbreak in Japan

    Seo Y.

    Journal of Echocardiography   18 ( 4 )   226 - 233   2020.12（ ISSN:13490222 ）

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  • JCS/JSCS/JATS/JSVS 2020 Guidelines on the Management of Valvular Heart Disease Reviewed

    Izumi Chisato, Eishi Kiyoyuki, Ashihara Kyomi, Arita Takeshi, Otsuji Yutaka, Kunihara Takashi, Komiya Tatsuhiko, Shibata Toshihiko, Seo Yoshihiro, Daimon Masao, Takanashi Shuichiro, Tanaka Hiroyuki, Nakatani Satoshi, Ninami Hiroshi, Nishi Hiroyuki, Hayashida Kentaro, Yaku Hitoshi, Yamaguchi Junichi, Yamamoto Kazuhiro, Watanabe Hiroyuki, Abe Yukio, Amaki Makoto, Amano Masashi, Obase Kikuko, Tabata Minoru, Miura Takashi, Miyake Makoto, Murata Mitsushige, Watanabe Nozomi, Akasaka Takashi, Okita Yutaka, Kimura Takeshi, Sawa Yoshiki, Yoshida Kiyoshi

    CIRCULATION JOURNAL   84 ( 11 )   2037 - 2119   2020.11（ ISSN:1346-9843 ）

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.1253/circj.CJ-20-0135

  • JCS/JSCS/JATS/JSVS 2020 Guidelines on the Management of Valvular Heart Disease

    Izumi C.

    Circulation Journal   84 ( 11 )   2037 - 2119   2020.10（ ISSN:13469843 ）

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  • Association between Serum Zinc and Calcification Propensity (T<sub>50</sub>) in Patients with Type 2 Diabetes Mellitus and In Vitro Effect of Exogenous Zinc on T<sub>50</sub>.

    Nakatani S, Mori K, Sonoda M, Nishide K, Uedono H, Tsuda A, Emoto M, Shoji T

    Biomedicines   8 ( 9 )   2020.09

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  • Association between Serum Zinc and Calcification Propensity (T-50) in Patients with Type 2 Diabetes Mellitus and In Vitro Effect of Exogenous Zinc on T-50 Reviewed

    Nakatani Shinya, Mori Katsuhito, Sonoda Mika, Nishide Kozo, Uedono Hideki, Tsuda Akihiro, Emoto Masanori, Shoji Tetsuo

    BIOMEDICINES   8 ( 9 )   2020.09

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.3390/biomedicines8090337

    PubMed

  • 感染後糸球体腎炎を契機に発症した高齢者微小変化型ネフローゼ症候群のステロイド治療完全寛解症例

    加藤 陽子, 渡邉 美季, 小川 啓子, 藤本 昌代, 兵頭 俊紀, 仲谷 慎也, 武曽 恵理, 石村 栄治

    日本腎臓学会誌   62 ( 6 )   674 - 674   2020.09（ ISSN:0385-2385 ）

  • シナカルセトが腎容積の増大を抑制したADPKD透析患者の一例

    仲谷 慎也, 森 克仁, 西出 孝蔵, 奥野 仙二, 石村 栄治, 待場 優里, 森岡 史行, 上殿 英記, 津田 昌宏, 繪本 正憲

    日本腎臓学会誌   62 ( 6 )   656 - 656   2020.09（ ISSN:0385-2385 ）

  • 間質性腎炎の原因鑑別に苦慮したoverlap症候群の一例

    並木 雄太, 上殿 英記, 西出 孝蔵, 待場 優里, 森岡 史行, 仲谷 慎也, 津田 昌宏, 森 克仁, 絵本 正憲

    日本腎臓学会誌   62 ( 6 )   675 - 675   2020.09（ ISSN:0385-2385 ）

  • 人間ドック受診者における血漿キサンチン酸化還元酵素活性と平均血圧との関連 酸化ストレスによる修飾

    吉田 潮, 藏城 雅文, 福本 真也, 村瀬 貴代, 中村 敬志, 吉田 寿子, 仲谷 慎也, 津田 昌宏, 森岡 与明, 森 克仁, 今西 康雄, 稲葉 雅章, 絵本 正憲

    糖尿病   63 ( Suppl.1 )   S - 206   2020.08（ ISSN:0021-437X ） （ eISSN:1881-588X ）

  • Gastrointestinal Endoscopy for Patients with High Levels of Serum CEA and CA19-9(和訳中) Reviewed

    Suzuki Norihiro, Katagiri Atsushi, Nakatani Shinya, Kikuchi Kazuo, Gocho Toshihiko, Yanagisawa Fumito, Inoki Kazuya, Konda Kenichi, Tojo Masayuki, Kubota Yutaro, Konishi Kazuo, Yamamura Fuyuhiko, Yoshida Hitoshi

    昭和大学学士会　The Showa University Journal of Medical Sciences   32 ( 2 )   115 - 123   2020.07（ ISSN:0915-6380 ）

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    Publishing type：Research paper (scientific journal)  

  • 血清CEAおよびCA19-9の高値患者に対する消化管内視鏡検査(Gastrointestinal Endoscopy for Patients with High Levels of Serum CEA and CA19-9)

    Suzuki Norihiro, Katagiri Atsushi, Nakatani Shinya, Kikuchi Kazuo, Gocho Toshihiko, Yanagisawa Fumito, Inoki Kazuya, Konda Kenichi, Tojo Masayuki, Kubota Yutaro, Konishi Kazuo, Yamamura Fuyuhiko, Yoshida Hitoshi

    The Showa University Journal of Medical Sciences   32 ( 2 )   115 - 123   2020.07（ ISSN:0915-6380 ）

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    血清癌胎児性抗原(CEA)および炭水化物抗原19-9(CA19-9)の高値患者を対象に、消化管(GI)内視鏡検査による悪性腫瘍の検出率を調べた。2018年1月〜2019年2月の間にGI内視鏡検査を受けた患者156名(男性76名、女性80名、平均65.6歳)を、血清CEA/CA19-9値を測定する目的に応じて、フォローアップ(FU)群とスクリーニング(S)群に分けた。S群では、GI悪性腫瘍が6例(5.7%)検出されたが、貧血のない無症候性の患者では検出されなかった。FU群では、GI悪性腫瘍の4例(7.8%)が検出され、3名の患者は無症候性であり、1名の患者は貧血であった。以上より、貧血がなく、悪性腫瘍の病歴のない無症候性患者における高い血清CEA/CA19-9値は、悪性腫瘍の存在を示さないと考えられた。

  • Independent association of plasma xanthine oxidoreductase activity with serum uric acid level based on stable isotope-labeled xanthine and liquid chromatography/triple quadrupole mass spectrometry: MedCity21 health examination registry Reviewed

    Kurajoh Masafumi, Fukumoto Shinya, Emoto Masanori, Murase Takayo, Nakamura Takashi, Ishihara Takuma, Go Hirofumi, Yamamoto Kouji, Nakatani Shinya, Tsuda Akihiro, Yamada Shinsuke, Morioka Tomoaki, Mori Katsuhito, Imanishi Yasuo, Inaba Masaaki

    CLINICAL CHEMISTRY AND LABORATORY MEDICINE   58 ( 5 )   780 - 786   2020.05（ ISSN:1434-6621 ）

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.1515/cclm-2019-0199

    PubMed

  • Independent association of plasma xanthine oxidoreductase activity with serum uric acid level based on stable isotope-labeled xanthine and liquid chromatography/triple quadrupole mass spectrometry: MedCity21 health examination registry.

    Kurajoh M, Fukumoto S, Emoto M, Murase T, Nakamura T, Ishihara T, Go H, Yamamoto K, Nakatani S, Tsuda A, Yamada S, Morioka T, Mori K, Imanishi Y, Inaba M

    Clinical chemistry and laboratory medicine   58 ( 5 )   780 - 786   2020.04（ ISSN:1434-6621 ）

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  • Long-Term Effects of High-Dose Tolvaptan for Autosomal Dominant Polycystic Kidney Disease Patients.

    Nakatani S, Ishimura E, Machiba Y, Fujimoto K, Uedono H, Tsuda A, Mori K, Emoto M, Inaba M

    Case reports in nephrology and dialysis   10 ( 1 )   9 - 17   2020.01

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  • Long-Term Effects of High-Dose Tolvaptan for Autosomal Dominant Polycystic Kidney Disease Patients Reviewed

    Nakatani Shinya, Ishimura Eiji, Machiba Yuri, Fujimoto Kenta, Uedono Hideki, Tsuda Akihiro, Mori Katsuhito, Emoto Masanori, Inaba Masaaki

    CASE REPORTS IN NEPHROLOGY AND DIALYSIS   10 ( 1 )   9 - 17   2020（ ISSN:2296-9705 ）

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.1159/000506118

    PubMed

  • Increased Glomerular Hydrostatic Pressure is Associated with Tubular Creatinine Reabsorption in Healthy Subjects.

    Tsuda A, Ishimura E, Machiba Y, Uedono H, Nakatani S, Mori K, Uchida J, Emoto M

    Kidney & blood pressure research   45 ( 6 )   996 - 1008   2020（ ISSN:1420-4096 ）

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  • Insulin Resistance Associated with Plasma Xanthine Oxidoreductase Activity Independent of Visceral Adiposity and Adiponectin Level: MedCity21 Health Examination Registry Reviewed

    Kurajoh Masafumi, Fukumoto Shinya, Murase Takayo, Nakamura Takashi, Ishihara Takuma, Go Hirofumi, Yamamoto Kouji, Nakatani Shinya, Tsuda Akihiro, Morioka Tomoaki, Mori Katsuhito, Imanishi Yasuo, Inaba Masaaki, Emoto Masanori

    INTERNATIONAL JOURNAL OF ENDOCRINOLOGY   2019   1762161   2019.12（ ISSN:1687-8337 ）

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.1155/2019/1762161

    PubMed

  • 腎臓内科医が腎移植に携わるための方策　アンケート調査より Reviewed

    仲谷 慎也, 祖父江 理, 一居 充, 嶋津 啓二, 森岡 史行, 大野 良晃, 庄司 繁市, 立石 悠, 関根 章成, 園田 美香, 石村 栄治, 岩井 友明, 内田 潤次, 稲葉 雅章, 仲谷 達也

    (一社)日本臨床腎移植学会　日本臨床腎移植学会雑誌   7 ( 2 )   143 - 149   2019.12（ ISSN:2187-9907 ）

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    Publishing type：Research paper (scientific journal)  

    腎移植における生着率・生存率の向上および生体腎移植の増加により、保存期慢性腎臓病としてフォローされるべきレシピエントとドナーは増加している。一方、腎臓内科医が積極的に腎移植に参加しているとは言いがたいのが本邦の現状である。今回、腎臓内科医が腎移植に携わる方策を検討する目的で、11施設の腎臓内科医にアンケート調査を行った。腎移植に興味があり、かかわるべきだと感じているが、得意ではなく、携わっていないという回答が大半であった。腎移植の説明以上のかかわり方が分からず、「腎移植に関する知識」、「腎臓内科医をとりまく環境」、「移植医との連携」の3つの課題が浮き彫りとなった。移植医療のさらなる発展にはより多くの腎臓内科医の関与が必要であり、これらの課題を克服するために、初心者向けの研究会・セミナー・シンポジウムの開催、研修制度の整備、移植医との合同カンファレンスなどの改善策があげられる。(著者抄録)

  • 腎臓内科医が腎移植に携わるための方策　アンケート調査より

    仲谷 慎也, 祖父江 理, 一居 充, 嶋津 啓二, 森岡 史行, 大野 良晃, 庄司 繁市, 立石 悠, 関根 章成, 園田 美香, 石村 栄治, 岩井 友明, 内田 潤次, 稲葉 雅章, 仲谷 達也

    日本臨床腎移植学会雑誌   7 ( 2 )   143 - 149   2019.12（ ISSN:2187-9907 ）

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    腎移植における生着率・生存率の向上および生体腎移植の増加により、保存期慢性腎臓病としてフォローされるべきレシピエントとドナーは増加している。一方、腎臓内科医が積極的に腎移植に参加しているとは言いがたいのが本邦の現状である。今回、腎臓内科医が腎移植に携わる方策を検討する目的で、11施設の腎臓内科医にアンケート調査を行った。腎移植に興味があり、かかわるべきだと感じているが、得意ではなく、携わっていないという回答が大半であった。腎移植の説明以上のかかわり方が分からず、「腎移植に関する知識」、「腎臓内科医をとりまく環境」、「移植医との連携」の3つの課題が浮き彫りとなった。移植医療のさらなる発展にはより多くの腎臓内科医の関与が必要であり、これらの課題を克服するために、初心者向けの研究会・セミナー・シンポジウムの開催、研修制度の整備、移植医との合同カンファレンスなどの改善策があげられる。(著者抄録)

  • キサンチン酸化還元酵素活性と血圧の関連

    吉田 潮, 藏城 雅文, 福本 真也, 村瀬 貴代, 中村 敬志, 仲谷 慎也, 津田 昌宏, 森岡 与明, 森 克仁, 今西 康雄, 絵本 正憲, 稲葉 雅章

    痛風と尿酸・核酸   43 ( 1 )   69   2019.07（ eISSN:24350095 ）

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  • 血漿中キサンチン酸化還元酵素活性は血清尿酸値と独立して関連する

    藏城 雅文, 福本 真也, 村瀬 貴代, 中村 敬志, 石原 拓磨, 郷 洋文, 山本 紘司, 仲谷 慎也, 津田 昌宏, 森岡 与明, 森 克仁, 今西 康雄, 絵本 正憲, 稲葉 雅章

    痛風と尿酸・核酸   43 ( 1 )   72 - 73   2019.07（ eISSN:24350095 ）

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  • Effect of Left Ventricular Reverse Remodeling on Long-term Outcomes After Aortic Valve Replacement

    Izumi C.

    American Journal of Cardiology   124 ( 1 )   105 - 112   2019.07（ ISSN:00029149 ）

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  • CREATININE REABSORPTION IN TUBULI IN HEALTHY SUBJECTS - A ROLE OF INTRARENAL PHYSICAL PRESSURE Reviewed

    Tsuda Akihiro, Ishimura Eiji, Machiba Yuri, Uedono Hideki, Nakatani Shinya, Mori Katsuhito, Uchida Junji, Emoto Masanori, Nakatani Tatsuya, Inaba Masaaki

    NEPHROLOGY DIALYSIS TRANSPLANTATION   34   2019.06（ ISSN:0931-0509 ）

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    Publishing type：Research paper (scientific journal)  

  • RELATIONSHIP BETWEEN SERUM THYROID STIMULATING HORMONE LEVELS AND INTRARENAL HEMODYNAMIC PARAMETERS IN SUBJECTS WITH SUBCLINICAL HYPOTHYROIDISM Reviewed

    Nakatani Shinya, Ishimura Eiji, Machiba Yuri, Uedono Hideki, Nagata Yuki, Tsuda Akihiro, Kurajoh Masafumi, Yamada Shinsuke, Mori Katsuhito, Uchida Junji, Emoto Masanori, Nakatani Tatsuya, Inaba Masaaki

    NEPHROLOGY DIALYSIS TRANSPLANTATION   34   2019.06（ ISSN:0931-0509 ）

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    Publishing type：Research paper (scientific journal)  

  • PLASMA OXIDIZED LDL LEVEL AND RISK OF CARDIOVASCULAR EVENTS IN A COHORT OF HEMODIALYSIS PATIENTS: THE DREAM COHORT STUDY Reviewed

    Shoji Tetsuo, Miyashima Masako, Nakaya Rino, Sasaki Keyaki, Nakatani Shinya, Emoto Masanori, Mori Katsuhito, Tsujimoto Yoshihiro, Inaba Masaaki

    NEPHROLOGY DIALYSIS TRANSPLANTATION   34   2019.06（ ISSN:0931-0509 ）

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    Publishing type：Research paper (scientific journal)  

  • OXIDATIVE STRESS AS A PREDICTOR OF MORTALITY AND CARDIOVASCULAR EVENTS IN HEMODIALYSIS PATIENTS:THE DREAM COHORT STUDY Reviewed

    Sasaki Keyaki, Shoji Tetsuo, Okute Yujiro, Tsuchikura Shoko, Shimomura Naoko, Tsujimoto Yoshihiro, Nishizawa Yoshiki, Nakatani Shinya, Mori Katsuhito, Shioi Atsushi, Hayashi Tomoshige, Emoto Masanori, Inaba Masaaki

    NEPHROLOGY DIALYSIS TRANSPLANTATION   34   2019.06（ ISSN:0931-0509 ）

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    Publishing type：Research paper (scientific journal)  

  • INSULIN RESISTANCE IN SUBJECTS WITH IMPAIRED FASTING GLUCOSE AND/OR IMPAIRED GLUCOSE TOLERANCE IS SIGNIFICANTLY ASSOCIATED WITH INTRAGLOMERULAR HYDROSTATIC PRESSURE AND ALBUMINURIA Reviewed

    Ishimura Eiji, Tsuda Akihiro, Machiba Yuri, Uedono Hideki, Ochi Akinobu, Nakatani Shinya, Morioka Tomoaki, Mori Katsuhito, Uchida Junji, Emoto Masanori, Nakatani Tatsuya, Inaba Masaaki

    NEPHROLOGY DIALYSIS TRANSPLANTATION   34   2019.06（ ISSN:0931-0509 ）

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    Publishing type：Research paper (scientific journal)  

  • EFFECTS OF FETUIN-A-CONTAINING CALCIPROTEIN PARTICLE (CPP) ON POSTTRANSLATIONAL MODIFICATIONS OF FETUIN-A IN HEPG2 CELLS Reviewed

    Uedono Hideki, Mori Katsuhito, Ochi Akinobu, Nakatani Shinya, Tsuda Akihiro, Shoji Tetsuo, Emoto Masanori, Inaba Masaaki

    NEPHROLOGY DIALYSIS TRANSPLANTATION   34   2019.06（ ISSN:0931-0509 ）

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    Publishing type：Research paper (scientific journal)  

  • Multicenter Prospective Study of Color Doppler Ultrasound for Breast Masses: Utility of Our Color Doppler Method

    Watanabe T.

    Ultrasound in Medicine and Biology   45 ( 6 )   1367 - 1379   2019.06（ ISSN:03015629 ）

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  • Impact of diabetes on sarcopenia and mortality in patients undergoing hemodialysis Reviewed

    Mori Katsuhito, Nishide Kozo, Okuno Senji, Shoji Tetsuo, Emoto Masanori, Tsuda Akihiro, Nakatani Shinya, Imanishi Yasuo, Ishimura Eiji, Yamakawa Tomoyuki, Shoji Shigeichi, Inaba Masaaki

    BMC NEPHROLOGY   20 ( 1 )   105   2019.03

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.1186/s12882-019-1271-8

    PubMed

  • Impact of diabetes on sarcopenia and mortality in patients undergoing hemodialysis.

    Mori K, Nishide K, Okuno S, Shoji T, Emoto M, Tsuda A, Nakatani S, Imanishi Y, Ishimura E, Yamakawa T, Shoji S, Inaba M

    BMC nephrology   20 ( 1 )   105   2019.03

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  • Significance of urinary C-megalin excretion in vitamin D metabolism in pre-dialysis CKD patients Reviewed

    Toi Norikazu, Inaba Masaaki, Ishimura Eiji, Tsugawa Naoko, Imanishi Yasuo, Emoto Masanori, Hirayama Yoshiaki, Nakatani Shinya, Saito Akihiko, Yamada Shinsuke

    SCIENTIFIC REPORTS   9 ( 1 )   2207   2019.02（ ISSN:2045-2322 ）

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.1038/s41598-019-38613-8

    PubMed

  • Significance of urinary C-megalin excretion in vitamin D metabolism in pre-dialysis CKD patients.

    Toi N, Inaba M, Ishimura E, Tsugawa N, Imanishi Y, Emoto M, Hirayama Y, Nakatani S, Saito A, Yamada S

    Scientific reports   9 ( 1 )   2207   2019.02

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  • [Primary appendiceal signet ring cell carcinoma:a case report]. Reviewed

    Nakajima Y, Kajiwara A, Sakaki M, Otoyama Y, Nishihara S, Suzuki N, Usami T, Nakatani S, Wang T, Yoshida H

    Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology   116 ( 11 )   927 - 933   2019（ ISSN:0446-6586 ）

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.11405/nisshoshi.116.927

    PubMed

  • キサンチン酸化還元酵素活性と血圧の関連 Reviewed

    吉田 潮, 今西 康雄, 絵本 正憲, 稲葉 雅章, 藏城 雅文, 福本 真也, 村瀬 貴代, 中村 敬志, 仲谷 慎也, 津田 昌宏, 森岡 与明, 森 克仁

    一般社団法人 日本痛風・尿酸核酸学会　痛風と尿酸・核酸   43 ( 1 )   2019

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.14867/gnamtsunyo.43.1_69

    CiNii Research

  • Effects of Long-Term Cinacalcet Administration on Parathyroid Gland in Hemodialysis Patients with Secondary Hyperparathyroidism Reviewed

    Okuno Senji, Inaba Masaaki, Ishimura Eiji, Nakatani Shinya, Chou Hidenori, Shoji Shigeichi, Yamakawa Tomoyuki

    NEPHRON   142 ( 2 )   106 - 113   2019（ ISSN:1660-8151 ）

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.1159/000496808

    PubMed

  • JCS 2016 guideline on diagnosis and treatment of cardiac sarcoidosis ― digest version ―

    Terasaki F.

    Circulation Journal   83 ( 11 )   2329 - 2388   2019（ ISSN:13469843 ）

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  • Insulin Resistance Associated with Plasma Xanthine Oxidoreductase Activity Independent of Visceral Adiposity and Adiponectin Level: MedCity21 Health Examination Registry.

    Kurajoh M, Fukumoto S, Murase T, Nakamura T, Ishihara T, Go H, Yamamoto K, Nakatani S, Tsuda A, Morioka T, Mori K, Imanishi Y, Inaba M, Emoto M

    International journal of endocrinology   2019   1762161   2019（ ISSN:1687-8337 ）

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  • Effects of Long-Term Cinacalcet Administration on Parathyroid Gland in Hemodialysis Patients with Secondary Hyperparathyroidism.

    Okuno S, Inaba M, Ishimura E, Nakatani S, Chou H, Shoji S, Yamakawa T

    Nephron   142 ( 2 )   106 - 113   2019（ ISSN:1660-8151 ）

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  • [Primary appendiceal signet ring cell carcinoma:a case report].

    Nakajima Y, Kajiwara A, Sakaki M, Otoyama Y, Nishihara S, Suzuki N, Usami T, Nakatani S, Wang T, Yoshida H

    Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology   116 ( 11 )   927 - 933   2019（ ISSN:0446-6586 ）

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  • Non-mercaptalbumin, Oxidized Form of Serum Albumin, Significantly Associated with Renal Function and Anemia in Chronic Kidney Disease Patients Reviewed

    Nakatani Shinya, Yasukawa Keiko, Ishimura Eiji, Nakatani Ayumi, Toi Norikazu, Uedono Hideki, Tsuda Akihiro, Yamada Shinsuke, Ikeda Hitoshi, Mori Katsuhito, Emoto Masanori, Yatomi Yutaka, Inaba Masaaki

    SCIENTIFIC REPORTS   8 ( 1 )   16796   2018.11（ ISSN:2045-2322 ）

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.1038/s41598-018-35177-x

    PubMed

  • Non-mercaptalbumin, Oxidized Form of Serum Albumin, Significantly Associated with Renal Function and Anemia in Chronic Kidney Disease Patients.

    Nakatani S, Yasukawa K, Ishimura E, Nakatani A, Toi N, Uedono H, Tsuda A, Yamada S, Ikeda H, Mori K, Emoto M, Yatomi Y, Inaba M

    Scientific reports   8 ( 1 )   16796   2018.11

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  • Association of Albuminuria With Intraglomerular Hydrostatic Pressure and Insulin Resistance in Subjects With Impaired Fasting Glucose and/or Impaired Glucose Tolerance Reviewed

    Tsuda Akihiro, Ishimura Eiji, Uedono Hideki, Ochi Akinobu, Nakatani Shinya, Morioka Tomoaki, Mori Katsuhito, Uchida Junji, Emoto Masanori, Nakatani Tatsuya, Inaba Masaaki

    DIABETES CARE   41 ( 11 )   2414 - 2420   2018.11（ ISSN:0149-5992 ）

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.2337/dc18-0718

    PubMed

  • Association of Albuminuria With Intraglomerular Hydrostatic Pressure and Insulin Resistance in Subjects With Impaired Fasting Glucose and/or Impaired Glucose Tolerance.

    Tsuda A, Ishimura E, Uedono H, Ochi A, Nakatani S, Morioka T, Mori K, Uchida J, Emoto M, Nakatani T, Inaba M

    Diabetes care   41 ( 11 )   2414 - 2420   2018.11（ ISSN:0149-5992 ）

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  • Novel increasing dose regimen of tolvaptan for autosomal dominant polycystic kidney disease in patient with low tolerability Reviewed

    Nakatani Shinya, Ishimura Eiji, Machiba Yuri, Nakatani Ayumi, Fujimoto Kenta, Uedono Hideki, Okute Yujiro, Tsuda Akihiro, Mori Katsuhito, Emoto Masanori, Inaba Masaaki

    NEPHROLOGY   23 ( 8 )   798 - 799   2018.08（ ISSN:1320-5358 ）

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.1111/nep.13196

    PubMed

  • Novel increasing dose regimen of tolvaptan for autosomal dominant polycystic kidney disease in patient with low tolerability.

    Nakatani S, Ishimura E, Machiba Y, Nakatani A, Fujimoto K, Uedono H, Okute Y, Tsuda A, Mori K, Emoto M, Inaba M

    Nephrology (Carlton, Vic.)   23 ( 8 )   798 - 799   2018.08（ ISSN:1320-5358 ）

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  • <b>人間ドック受診者におけるキサンチン酸化還元酵素活性と</b><b>糖代謝との関連</b>

    藏城 雅文, 福本 真也, 永田 友貴, 仲谷 慎也, 津田 昌宏, 元山 宏華, 森岡 与明, 山田 真介, 森 克仁, 今西 康雄, 絵本 正憲, 平田 一人, 村瀬 貴代, 中村 敬志, 稲葉 雅章

    痛風と核酸代謝   42 ( 1 )   102   2018.07（ ISSN:13449796 ） （ eISSN:21866368 ）

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  • The Efficacy of Low-Density Lipoprotein Apheresis in a Patient with Drug-Resistant Minimal Change Nephrotic Syndrome: A Case Report and A Review of the Literature Reviewed

    Nakatani Shinya, Ishimura Eiji, Okute Yujiro, Nakatani Ayumi, Uedono Hideki, Tsuda Akihiro, Naganuma Toshihide, Takemoto Yoshiaki, Mori Katsuhito, Emoto Masanori, Inaba Masaaki

    NEPHROLOGY   23 ( 6 )   603 - 604   2018.06（ ISSN:1320-5358 ）

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.1111/nep.13120

    PubMed

  • The Efficacy of Low-Density Lipoprotein Apheresis in a Patient with Drug-Resistant Minimal Change Nephrotic Syndrome: A Case Report and A Review of the Literature.

    Nakatani S, Ishimura E, Okute Y, Nakatani A, Uedono H, Tsuda A, Naganuma T, Takemoto Y, Mori K, Emoto M, Inaba M

    Nephrology (Carlton, Vic.)   23 ( 6 )   603 - 604   2018.06（ ISSN:1320-5358 ）

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  • Development of hyperkalemia following treatment with dapagliflozin (DAPA) in a patient with type 2 diabetes after bilateral adrenalectomy Reviewed

    Miyaoka Daichi, Tsuda Akihiro, Hayashi Noriyuki, Toi Norikazu, Yamasaki Akiyo, Nagata Yuki, Nakatani Shinya, Kurajoh Masafumi, Yamada Shinsuke, Morioka Tomoaki, Imanishi Yasuo, Emoto Masanori, Inaba Masaaki

    CEN CASE REPORTS   7 ( 1 )   29 - 33   2018.05（ ISSN:2192-4449 ）

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.1007/s13730-017-0286-x

    PubMed

  • 両側性副腎摘出術後の2型糖尿病患者におけるダパグリフロジン(DAPA)治療後の高カリウム血症の発現(Development of hyperkalemia following treatment with dapagliflozin(DAPA) in a patient with type 2 diabetes after bilateral adrenalectomy) Reviewed

    Miyaoka Daichi, Tsuda Akihiro, Hayashi Noriyuki, Toi Norikazu, Yamasaki Akiyo, Nagata Yuki, Nakatani Shinya, Kurajoh Masafumi, Yamada Shinsuke, Morioka Tomoaki, Imanishi Yasuo, Emoto Masanori, Inaba Masaaki

    シュプリンガー・ジャパン(株)　CEN Case Reports   7 ( 1 )   29 - 33   2018.05

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    Publishing type：Research paper (scientific journal)  

    症例は79歳女性で、70歳時に手術不能のクッシング病再発によるコントロール不良の副腎皮質機能亢進症に対して両側性副腎摘出術を行い、術後はグルココルチコイド補充療法を行っていた。71歳時に2型糖尿病と診断され、シタグリプチンとミグリトールによる治療を行った。79歳時に6ヵ月間で体重が約5kg増加し、HbA1c>12%となったため、来院した。ダパグリフロジン(DAPA)5mg/日を追加すると、高カリウム血症が出現し(6.5mEq/L)、血漿レニン活性が53.1ng/mL/時に上昇した。アルドステロン欠乏症と診断し、フルドロコルチゾン0.1mg/日を開始すると、翌日の血清カリウムは5.8mEq/Lに低下し、7日後には血清カリウム4.0mEq/L、血漿レニン活性5.8ng/mL/時となった。

  • Development of hyperkalemia following treatment with dapagliflozin (DAPA) in a patient with type 2 diabetes after bilateral adrenalectomy.

    Miyaoka D, Tsuda A, Hayashi N, Toi N, Yamasaki A, Nagata Y, Nakatani S, Kurajoh M, Yamada S, Morioka T, Imanishi Y, Emoto M, Inaba M

    CEN case reports   7 ( 1 )   29 - 33   2018.05

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  • 両側性副腎摘出術後の2型糖尿病患者におけるダパグリフロジン(DAPA)治療後の高カリウム血症の発現(Development of hyperkalemia following treatment with dapagliflozin(DAPA) in a patient with type 2 diabetes after bilateral adrenalectomy)

    Miyaoka Daichi, Tsuda Akihiro, Hayashi Noriyuki, Toi Norikazu, Yamasaki Akiyo, Nagata Yuki, Nakatani Shinya, Kurajoh Masafumi, Yamada Shinsuke, Morioka Tomoaki, Imanishi Yasuo, Emoto Masanori, Inaba Masaaki

    CEN Case Reports   7 ( 1 )   29 - 33   2018.05

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    症例は79歳女性で、70歳時に手術不能のクッシング病再発によるコントロール不良の副腎皮質機能亢進症に対して両側性副腎摘出術を行い、術後はグルココルチコイド補充療法を行っていた。71歳時に2型糖尿病と診断され、シタグリプチンとミグリトールによる治療を行った。79歳時に6ヵ月間で体重が約5kg増加し、HbA1c>12%となったため、来院した。ダパグリフロジン(DAPA)5mg/日を追加すると、高カリウム血症が出現し(6.5mEq/L)、血漿レニン活性が53.1ng/mL/時に上昇した。アルドステロン欠乏症と診断し、フルドロコルチゾン0.1mg/日を開始すると、翌日の血清カリウムは5.8mEq/Lに低下し、7日後には血清カリウム4.0mEq/L、血漿レニン活性5.8ng/mL/時となった。

  • 特集 腎疾患2 【慢性腎臓病(CKD)】 【コラム⑫】CKDと妊娠-理解しておくべきリスクと対応:ガイドライン2017と最新の知見から

    仲谷 慎也, 森 克仁

    Hospitalist   6 ( 1 )   196 - 202   2018.03（ ISSN:21880409 ） （ eISSN:21896429 ）

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  • Urinary Iron Excretion is Associated with Urinary Full-Length Megalin and Renal Oxidative Stress in Chronic Kidney Disease Reviewed

    Nakatani Shinya, Nakatani Ayumi, Ishimura Eiji, Toi Norikazu, Tsuda Akihiro, Mori Katsuhito, Emoto Masanori, Hirayama Yoshiaki, Saito Akihiko, Inaba Masaaki

    KIDNEY & BLOOD PRESSURE RESEARCH   43 ( 2 )   458 - 470   2018（ ISSN:1420-4096 ）

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.1159/000488470

    PubMed

  • Non-mercaptalbumin, Oxidized Form of Serum Albumin, Significantly Associated with Renal Function and Anemia in Chronic Kidney Disease Patients Reviewed

    仲谷慎也, 森克仁, 石村栄治, 絵本正憲, 稲葉雅章

    Scientific Reports   2018

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  • <b>人間ドック受診者におけるキサンチン酸化還元酵素活性と</b><b>糖代謝との関連</b> Reviewed

    藏城 雅文, 今西 康雄, 絵本 正憲, 平田 一人, 村瀬 貴代, 中村 敬志, 稲葉 雅章, 福本 真也, 永田 友貴, 仲谷 慎也, 津田 昌宏, 元山 宏華, 森岡 与明, 山田 真介, 森 克仁

    一般社団法人 日本痛風・核酸代謝学会　痛風と核酸代謝   42 ( 1 )   2018（ ISSN:1344-9796 ）

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.6032/gnam.42.102

    CiNii Research

  • Non-mercaptalbumin, Oxidized Form of Serum Albumin, Significantly Associated with Renal Function and Anemia in Chronic Kidney Disease Patients Reviewed

    仲谷慎也、森克仁、石村栄治、絵本正憲、稲葉雅章　他

    Scientific Reports   2018

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    Publishing type：Research paper (scientific journal)   Kind of work：Joint Work  

  • Non-mercaptalbumin, Oxidized Form of Serum Albumin, Significantly Associated with Renal Function and Anemia in Chronic Kidney Disease Patients Reviewed

    仲谷慎也, 森克仁, 石村栄治, 絵本正憲, 稲葉雅章

    Scientific Reports   2018

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  • Urinary Iron Excretion is Associated with Urinary Full-Length Megalin and Renal Oxidative Stress in Chronic Kidney Disease.

    Nakatani S, Nakatani A, Ishimura E, Toi N, Tsuda A, Mori K, Emoto M, Hirayama Y, Saito A, Inaba M

    Kidney & blood pressure research   43 ( 2 )   458 - 470   2018（ ISSN:1420-4096 ）

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  • Xanthine oxidoreductase activity is associated with serum uric acid and glycemic control in hemodialysis patients Reviewed

    Nakatani Ayumi, Nakatani Shinya, Ishimura Eiji, Murase Takayo, Nakamura Takashi, Sakura Mari, Tateishi Yu, Tsuda Akihiro, Kurajoh Masafumi, Mori Katsuhito, Emoto Masanori, Inaba Masaaki

    SCIENTIFIC REPORTS   7 ( 1 )   15416   2017.11（ ISSN:2045-2322 ）

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.1038/s41598-017-15419-0

    PubMed

  • Xanthine oxidoreductase activity is associated with serum uric acid and glycemic control in hemodialysis patients.

    Nakatani A, Nakatani S, Ishimura E, Murase T, Nakamura T, Sakura M, Tateishi Y, Tsuda A, Kurajoh M, Mori K, Emoto M, Inaba M

    Scientific reports   7 ( 1 )   15416   2017.11

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  • FOCAL ACCUMULATION OF (67)GALLIUM IN THE KIDNEY IN A PATIENT WITH ANTI-GLOMERULAR BASEMENT MEMBRANE GLOMERULONEPHRITIS Reviewed

    Ishimura Eiji, Okute Yujiro, Nakatani Shinya, Ichii Mitsuru, Tsuda Akihiro, Inaba Masaaki

    NEPHROLOGY   22 ( 9 )   728 - 729   2017.09（ ISSN:1320-5358 ）

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.1111/nep.12918

    PubMed

  • Focal accumulation of <sup>67</sup> gallium in the kidney in a patient with anti-glomerular basement membrane glomerulonephritis.

    Ishimura E, Okute Y, Nakatani S, Ichii M, Tsuda A, Inaba M

    Nephrology (Carlton, Vic.)   22 ( 9 )   728 - 729   2017.09（ ISSN:1320-5358 ）

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  • U-shaped relationship between serum uric acid levels and intrarenal hemodynamic parameters in healthy subjects.

    Uedono H, Tsuda A, Ishimura E, Nakatani S, Kurajoh M, Mori K, Uchida J, Emoto M, Nakatani T, Inaba M

    American journal of physiology. Renal physiology   312 ( 6 )   F992 - F997   2017.06（ ISSN:1931-857X ）

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  • U-shaped relationship between serum uric acid levels and intrarenal hemodynamic parameters in healthy subjects Reviewed

    Uedono Hideki, Tsuda Akihiro, Ishimura Eiji, Nakatani Shinya, Kurajoh Masafumi, Mori Katsuhito, Uchida Junji, Emoto Masanori, Nakatani Tatsuya, Inaba Masaaki

    AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY   312 ( 6 )   F992 - F997   2017.06（ ISSN:1931-857X ）

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.1152/ajprenal.00645.2016

    PubMed

  • 糖尿病とビタミン （シンポジウム「臨床におけるビタミン・バイオファクターの最近の話題」） Reviewed

    仲谷 慎也, 稲葉 雅章

    公益社団法人 日本ビタミン学会　ビタミン   91 ( 4 )   2017（ ISSN:0006-386X ）

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.20632/vso.91.4_250

    CiNii Research

  • <b>健常人（腎移植ドナー候補者）における尿酸と腎血行動態の関連性</b> Reviewed

    上殿 英記, 津田 昌宏, 石村 栄治, 上田 修子, 仲谷 慎也, 藏城 雅文, 森 克仁, 絵本 正憲, 稲葉 雅章

    一般社団法人 日本痛風・核酸代謝学会　痛風と核酸代謝   41 ( 1 )   92 - 93   2017（ ISSN:1344-9796 ）

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.6032/gnam.41.92

    CiNii Research

  • <b>健常人（腎移植ドナー候補者）における尿酸と腎血行動態の関連性</b>

    上殿 英記, 津田 昌宏, 石村 栄治, 上田 修子, 仲谷 慎也, 藏城 雅文, 森 克仁, 絵本 正憲, 稲葉 雅章

    痛風と核酸代謝   41 ( 1 )   92 - 93   2017（ ISSN:13449796 ） （ eISSN:21866368 ）

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  • 糖尿病とビタミン （シンポジウム「臨床におけるビタミン・バイオファクターの最近の話題」）

    仲谷 慎也, 稲葉 雅章

    ビタミン   91 ( 4 )   250   2017（ ISSN:0006386X ） （ eISSN:2424080X ）

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  • A CASE WITH NEPHROTIC SYNDROME AND RENAL FAILURE ASSOCIATED WITH SEVERELY PROLIFERATIVE HEPATIC IGA NEPHROPATHY Reviewed

    Ishimura E., Fukuda Y., Uedono H., Okude Y., Nakatani S., Tsuda A., Mori K., Inaba M.

    NEPHROLOGY   21   274 - 274   2016.09（ ISSN:1320-5358 ）

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  • GLOMERULAR HYPERFILTRATION AND INCREASED EFFERENT ARTERIOLAR RESISTANCE ARE PRESENT IN SUBJECTS WITH IMPAIRED GLUCOSE TOLERANCE Reviewed

    Tsuda A., Ishimura E., Uedono H., Nakatani S., Uchida J., Nakatani T., Inaba M.

    NEPHROLOGY   21   37 - 37   2016.09（ ISSN:1320-5358 ）

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  • GLOMERULAR HYPERFILTRATION AND INCREASED AFFERENT ARTERIOLAR RESISTANCE ARE PRESENT IN SUBJECTS WITH IMPAIRED GLUCOSE TOLERANCE Reviewed

    Ishimura Eiji, Tsuda Akihiro, Uedono Hideki, Yasumoto Mari, Nakatani Shinya, Ichii Mitsuru, Mori Katsuhito, Emoto Masanori, Inaba Masaaki

    NEPHROLOGY DIALYSIS TRANSPLANTATION   31   69 - 69   2016.05（ ISSN:0931-0509 ）

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  • INTEGRIN beta 1 IS NECESSARY FOR THE DEVELOPMENT OF RENAL MEDULLA Reviewed

    Nakatani Shinya, Ishimura Eiji, Inaba Masakaki, Kobayashi Akio

    NEPHROLOGY DIALYSIS TRANSPLANTATION   31   90 - 90   2016.05（ ISSN:0931-0509 ）

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  • Comparison of the Estimated Glomerular Filtration Rate (eGFR) in Diabetic Patients, Non-Diabetic Patients and Living Kidney Donors Reviewed

    Tsuda Akihiro, Ishimura Eiji, Uedono Hideki, Yasumoto Mari, Ichii Mitsuru, Nakatani Shinya, Mori Katsuhito, Uchida Junji, Emoto Masanori, Nakatani Tatsuya, Inaba Masaaki

    KIDNEY & BLOOD PRESSURE RESEARCH   41 ( 1 )   40 - 47   2016（ ISSN:1420-4096 ）

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.1159/000368545

    PubMed

  • Comparison of the Estimated Glomerular Filtration Rate (eGFR) in Diabetic Patients, Non-Diabetic Patients and Living Kidney Donors.

    Tsuda A, Ishimura E, Uedono H, Yasumoto M, Ichii M, Nakatani S, Mori K, Uchida J, Emoto M, Nakatani T, Inaba M

    Kidney & blood pressure research   41 ( 1 )   40 - 7   2016（ ISSN:1420-4096 ）

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  • Indoxyl sulfate suppresses hepatic fetuin-A expression via the aryl hydrocarbon receptor in HepG2 cells Reviewed

    Ochi Akinobu, Mori Katsuhito, Nakatani Shinya, Emoto Masanori, Morioka Tomoaki, Motoyama Koka, Fukumoto Shinya, Imanishi Yasuo, Shoji Tetsuo, Ishimura Eiji, Inaba Masaaki

    NEPHROLOGY DIALYSIS TRANSPLANTATION   30 ( 10 )   1683 - 1692   2015.10（ ISSN:0931-0509 ）

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.1093/ndt/gfv250

    PubMed

  • Indoxyl sulfate suppresses hepatic fetuin-A expression via the aryl hydrocarbon receptor in HepG2 cells.

    Ochi A, Mori K, Nakatani S, Emoto M, Morioka T, Motoyama K, Fukumoto S, Imanishi Y, Shoji T, Ishimura E, Inaba M

    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association   30 ( 10 )   1683 - 92   2015.10（ ISSN:0931-0509 ）

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  • Significant association between glycemic status and increased estimated postglomerular resistance in nondiabetic subjects - study of inulin and para-aminohippuric acid clearance in humans Reviewed

    Yasumoto Mari, Tsuda Akihiro, Ishimura Eiji, Uedono Hideki, Ohno Yoshiteru, Ichii Mitsuru, Ochi Akinobu, Nakatani Shinya, Mori Katsuhito, Uchida Junji, Emoto Masanori, Nakatani Tatsuya, Inaba Masaaki

    PHYSIOLOGICAL REPORTS   3 ( 3 )   2015.03（ ISSN:2051-817X ）

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.14814/phy2.12321

    PubMed

  • Significant association between glycemic status and increased estimated postglomerular resistance in nondiabetic subjects - study of inulin and para-aminohippuric acid clearance in humans.

    Yasumoto M, Tsuda A, Ishimura E, Uedono H, Ohno Y, Ichii M, Ochi A, Nakatani S, Mori K, Uchida J, Emoto M, Nakatani T, Inaba M

    Physiological reports   3 ( 3 )   2015.03

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  • Relationship Between Serum Uric Acid Levels and Intrarenal Hemodynamic Parameters Reviewed

    Uedono Hideki, Tsuda Akihiro, Ishimura Eiji, Yasumoto Mari, Ichii Mitsuru, Ochi Akinobu, Ohno Yoshiteru, Nakatani Shinya, Mori Katsuhito, Uchida Junji, Nakatani Tatsuya, Inaba Masaaki

    KIDNEY & BLOOD PRESSURE RESEARCH   40 ( 3 )   315 - 322   2015（ ISSN:1420-4096 ）

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.1159/000368507

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  • Fibroblast Growth Factor-23 and Vitamin D Metabolism in Subjects with eGFR >= 60 ml/min/1.73 m(2) Reviewed

    Nakatani Shinya, Nakatani Ayumi, Tsugawa Naoko, Yamada Shinsuke, Mori Katsuhito, Imanishi Yasuo, Ishimura Eiji, Okano Toshio, Inaba Masaaki

    NEPHRON   130 ( 2 )   119 - 126   2015（ ISSN:1660-8151 ）

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.1159/000430870

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  • Relationship between serum uric acid levels and intrarenal hemodynamic parameters.

    Uedono H, Tsuda A, Ishimura E, Yasumoto M, Ichii M, Ochi A, Ohno Y, Nakatani S, Mori K, Uchida J, Nakatani T, Inaba M

    Kidney & blood pressure research   40 ( 3 )   315 - 22   2015（ ISSN:1420-4096 ）

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  • Fibroblast Growth Factor-23 and Vitamin D Metabolism in Subjects with eGFR ≥60 ml/min/1.73 m².

    Nakatani S, Nakatani A, Tsugawa N, Yamada S, Mori K, Imanishi Y, Ishimura E, Okano T, Inaba M

    Nephron   130 ( 2 )   119 - 26   2015（ ISSN:1660-8151 ）

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  • SUCCESSFUL TREATMENT OF HEPATITIS B VIRUS-ASSOCIATED MEMBRANOUS NEPHROPATHY WITH ENTECAVIR AND IMMUNOSUPPRESSIVE AGENTS Reviewed

    Ochi Akinobu, Ishimura Eiji, Ichii Mitsuru, Ohno Yoshiteru, Nakatani Shinya, Kobayashi Ikue, Shima Hideaki, Tsuda Akihiro, Shidara Kaori, Mori Katsuhito, Tamori Akihiro, Inaba Masaaki

    NEPHROLOGY   19 ( 9 )   595 - 596   2014.09（ ISSN:1320-5358 ）

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.1111/nep.12292

    PubMed

  • Successful Treatment of Hepatitis B Virus-associated Membranous Nephropathy with Entecavir and Immunosuppressive Agents.

    Ochi A, Ishimura E, Ichii M, Ohno Y, Nakatani S, Kobayashi I, Shima H, Tsuda A, Shidara K, Mori K, Tamori A, Inaba M

    Nephrology (Carlton, Vic.)   19 ( 9 )   595 - 6   2014.09（ ISSN:1320-5358 ）

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  • Effect of corticosteroid therapy on renal pathology in IgG4-related kidney disease accompanying glomerulonephritis Reviewed

    Nakatani Shinya, Ishimura Eiji, Sonoda Mika, Ichii Mitsuru, Ochi Akinobu, Tsuda Akihiro, Kobayashi Ikue, Mori Katsuhito, Osawa Masahiko, Inaba Masaaki

    NEPHROLOGY   19 ( 7 )   436 - 437   2014.07（ ISSN:1320-5358 ）

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.1111/nep.12259

    PubMed

  • Poor glycemic control and decreased renal function are associated with increased intrarenal RAS activity in Type 2 diabetes mellitus Reviewed

    Nakatani S., Ishimura E., Naganuma T., Nakatani A., Ichii M., Fukumoto S., Mori K., Emoto M., Nakatani T., Inaba M.

    DIABETES RESEARCH AND CLINICAL PRACTICE   105 ( 1 )   40 - 46   2014.07（ ISSN:0168-8227 ）

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.diabres.2014.04.019

  • Effect of corticosteroid therapy on renal pathology in IgG4-related kidney disease accompanying glomerulonephritis.

    Nakatani S, Ishimura E, Sonoda M, Ichii M, Ochi A, Tsuda A, Kobayashi I, Mori K, Osawa M, Inaba M

    Nephrology (Carlton, Vic.)   19 ( 7 )   436 - 7   2014.07（ ISSN:1320-5358 ）

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  • A QUANTITATIVE ANALYSIS OF AORTIC CALCIFICATION IN PREDIALYSIS CKD PATIENTS BY USE OF AGATSTON SCORE Reviewed

    Ichii Mitsuru, Ishimura Eiji, Shima Hideaki, Ohno Yoshiteru, Tsuda Akihiro, Nakatani Shinya, Ochi Akinobu, Mori Katsuhito, Inaba Masaaki

    NEPHROLOGY DIALYSIS TRANSPLANTATION   29   156 - 156   2014.05（ ISSN:0931-0509 ）

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    Publishing type：Research paper (scientific journal)  

  • Significant association of poor glycemic control with increased resistance in efferent arterioles - Study of inulin and para-aminohippuric acid clearance in humans Reviewed

    Tsuda A., Ishimura E., Ohno Y., Ichii M., Nakatani S., Mori K., Fukumoto S., Emoto M., Inaba M.

    DIABETES RESEARCH AND CLINICAL PRACTICE   104 ( 2 )   234 - 240   2014.05（ ISSN:0168-8227 ）

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.diabres.2014.01.030

  • RELATIONSHIP BETWEEN GLOMERULAR FILTRATION RATE AND INSULIN RESISTANCE IN HEALTHY SUBJECTS Reviewed

    Yasumoto Mari, Tsuda Akihiro, Ishimura Eiji, Ohno Yoshiteru, Ichii Mitsuru, Nakatani Shinya, Mori Katsuhito, Fukumoto Shinya, Uchida Junji, Emoto Masanori, Nakatani Tatsuya, Inaba Masaaki

    NEPHROLOGY DIALYSIS TRANSPLANTATION   29   142 - 143   2014.05（ ISSN:0931-0509 ）

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  • NEW FORMULAE FOR MORE PRECISE ESTIMATION OF RENAL FUNCTION IN DIABETIC PATIENTS - EGFR CORRECTED BY HEMOGLOBIN AIC Reviewed

    Tsuda Akihiro, Ishimura Eiji, Uedono Hideki, Yasumoto Mari, Nakatani Shinya, Ichii Mitsuru, Ohno Yoshiteru, Ochi Akinobu, Mori Katsuhito, Fukumoto Shinya, Emoto Masanori, Inaba Masaaki

    NEPHROLOGY DIALYSIS TRANSPLANTATION   29   423 - 424   2014.05（ ISSN:0931-0509 ）

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  • Poor Glycemic Control Is a Major Factor in the Overestimation of Glomerular Filtration Rate in Diabetic Patients Reviewed

    Tsuda Akihiro, Ishimura Eiji, Ohno Yoshiteru, Ichii Mitsuru, Nakatani Shinya, Machida Yuuichi, Mori Katsuhito, Uchida Junji, Fukumoto Shinya, Emoto Masanori, Nakatani Tatsuya, Inaba Masaaki

    DIABETES CARE   37 ( 3 )   596 - 603   2014.03（ ISSN:0149-5992 ）

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.2337/dc13-1899

    PubMed

  • Direct Inhibitory Effects of Pioglitazone on Hepatic Fetuin-A Expression Reviewed

    Ochi Akinobu, Mori Katsuhito, Emoto Masanori, Nakatani Shinya, Morioka Tomoaki, Motoyama Koka, Fukumoto Shinya, Imanishi Yasuo, Koyama Hidenori, Ishimura Eiji, Inaba Masaaki

    PLOS ONE   9 ( 2 )   e88704   2014.02（ ISSN:1932-6203 ）

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.1371/journal.pone.0088704

    PubMed

  • Poor glycemic control is a major factor in the overestimation of glomerular filtration rate in diabetic patients.

    Tsuda A, Ishimura E, Ohno Y, Ichii M, Nakatani S, Machida Y, Mori K, Uchida J, Fukumoto S, Emoto M, Nakatani T, Inaba M

    Diabetes care   37 ( 3 )   596 - 603   2014（ ISSN:0149-5992 ）

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  • Direct inhibitory effects of pioglitazone on hepatic fetuin-A expression.

    Ochi A, Mori K, Emoto M, Nakatani S, Morioka T, Motoyama K, Fukumoto S, Imanishi Y, Koyama H, Ishimura E, Inaba M

    PloS one   9 ( 2 )   e88704   2014

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  • Relationship between serum TSH levels and intrarenal hemodynamic parameters in euthyroid subjects Reviewed

    Tsuda Akihiro, Inaba Masaaki, Ichii Mitsuru, Ochi Akinobu, Ohno Yoshiteru, Nakatani Shinya, Yamada Shinsuke, Mori Katsuhito, Tahara Hideki, Ishimura Eiji

    EUROPEAN JOURNAL OF ENDOCRINOLOGY   169 ( 1 )   45 - 50   2013.07（ ISSN:0804-4643 ）

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.1530/EJE-13-0026

    PubMed

  • Relationship between serum TSH levels and intrarenal hemodynamic parameters in euthyroid subjects.

    Tsuda A, Inaba M, Ichii M, Ochi A, Ohno Y, Nakatani S, Yamada S, Mori K, Tahara H, Ishimura E

    European journal of endocrinology   169 ( 1 )   45 - 50   2013.07（ ISSN:0804-4643 ）

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  • NEPHRONECTIN IS A NOVEL PROTEIN ASSOCIATED WITH DIABETIC NEPHROPATHY Reviewed

    Ishimura Eiji, Mori Katsuhito, Wanibuchi Hideki, Inaba Masaaki, Nakatani Shinya

    NEPHROLOGY DIALYSIS TRANSPLANTATION   28   16 - 17   2013.05（ ISSN:0931-0509 ）

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    Publishing type：Research paper (scientific journal)  

  • SILENT CEREBRAL MICROBLEEDS PREDICT GLOBAL OUTCOME IN PATIENTS WITH CHRONIC KIDNEY DISEASE Reviewed

    Shima Hideaki, Shoji Tetsuo, Naganuma Toshihide, Nakatani Shinya, Mori Katsuhito, Ishimura Eiji, Emoto Masanori, Okamura Mikio, Nakatani Tatsuya, Inaba Masaaki

    NEPHROLOGY DIALYSIS TRANSPLANTATION   28   355 - 355   2013.05（ ISSN:0931-0509 ）

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    Publishing type：Research paper (scientific journal)  

  • Quantitative Analysis of Abdominal Aortic Calcification in CKD Patients Without Dialysis Therapy by Use of the Agatston Score Reviewed

    Ichii Mitsuru, Ishimura Eiji, Shima Hideaki, Ohno Yoshiteru, Ochi Akinobu, Nakatani Shinya, Tsuda Akihiro, Ehara Shoichi, Mori Katsuhito, Fukumoto Shinya, Naganuma Toshihide, Takemoto Yoshiaki, Nakatani Tatsuya, Inaba Masaaki

    KIDNEY & BLOOD PRESSURE RESEARCH   38 ( 2-3 )   196 - 204   2013（ ISSN:1420-4096 ）

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.1159/000355768

    PubMed

  • Quantitative analysis of abdominal aortic calcification in CKD patients without dialysis therapy by use of the Agatston score.

    Ichii M, Ishimura E, Shima H, Ohno Y, Ochi A, Nakatani S, Tsuda A, Ehara S, Mori K, Fukumoto S, Naganuma T, Takemoto Y, Nakatani T, Inaba M

    Kidney & blood pressure research   38 ( 2-3 )   196 - 204   2013（ ISSN:1420-4096 ）

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  • EFFECT OF GLYCEMIC CONTROL ON GLOMERULAR HEMODYNAMIC MEASURED BY INULIN AND PARA-AMINOHYPURIC ACID CLEARANCE IN HUMAN-POOR GLYCEMIC CONTROL INDUCES INCREASED RESISTANCE OF EFFERENT ARTERIOLE Reviewed

    Tsuda Akihiro, Ishimura Eiji, Ohno Yoshiteru, Ichii Mitsuru, Nakatani Shinya, Mori Katsuhito, Inaba Masaaki

    NEPHROLOGY DIALYSIS TRANSPLANTATION   27   56 - 56   2012.05（ ISSN:0931-0509 ）

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    Publishing type：Research paper (scientific journal)  

  • Proteome analysis of laser microdissected glomeruli from formalin-fixed paraffin-embedded kidneys of autopsies of diabetic patients: nephronectin is associated with the development of diabetic glomerulosclerosis Reviewed

    Nakatani Shinya, Wei Min, Ishimura Eiji, Kakehashi Anna, Mori Katsuhito, Nishizawa Yoshiki, Inaba Masaaki, Wanibuchi Hideki

    NEPHROLOGY DIALYSIS TRANSPLANTATION   27 ( 5 )   1889 - 1897   2012.05（ ISSN:0931-0509 ）

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.1093/ndt/gfr682

    PubMed

  • Proteome analysis of laser microdissected glomeruli from formalin-fixed paraffin-embedded kidneys of autopsies of diabetic patients: nephronectin is associated with the development of diabetic glomerulosclerosis.

    Nakatani S, Wei M, Ishimura E, Kakehashi A, Mori K, Nishizawa Y, Inaba M, Wanibuchi H

    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association   27 ( 5 )   1889 - 97   2012.05（ ISSN:0931-0509 ）

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  • Nephronectin Expression in Glomeruli of Renal Biopsy Specimens from Various Kidney Diseases: Nephronectin Is Expressed in the Mesangial Matrix Expansion of Diabetic Nephropathy Reviewed

    Nakatani Shinya, Ishimura Eiji, Mori Katsuhito, Fukumoto Shinya, Yamano Shotaro, Wei Min, Emoto Masanori, Wanibuchi Hideki, Inaba Masaaki

    NEPHRON CLINICAL PRACTICE   122 ( 3-4 )   114 - 121   2012（ ISSN:1660-2110 ）

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.1159/000350816

    PubMed

  • Nephronectin expression in glomeruli of renal biopsy specimens from various kidney diseases: nephronectin is expressed in the mesangial matrix expansion of diabetic nephropathy.

    Nakatani S, Ishimura E, Mori K, Fukumoto S, Yamano S, Wei M, Emoto M, Wanibuchi H, Inaba M

    Nephron. Clinical practice   122 ( 3-4 )   114 - 21   2012（ ISSN:1660-8151 ）

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  • Gender Differences in Age-Related Changes in Left and Right Ventricular Geometries and Functions - Echocardiography of a Healthy Subject Group Reviewed

    Daimon Masao, Watanabe Hiroyuki, Abe Yukio, Hirata Kumiko, Hozumi Takeshi, Ishii Katsuhisa, Ito Hiroshi, Iwakura Katsuomi, Izumi Chisato, Matsuzaki Masunori, Minagoe Shinichi, Abe Haruhiko, Murata Kazuya, Nakatani Satoshi, Negishi Kazuaki, Yoshida Ken, Tanabe Kazuaki, Tanaka Nobuhiro, Tokai Kotaro, Yoshikawa Junichi

    CIRCULATION JOURNAL   75 ( 12 )   2840 - 2846   2011.12（ ISSN:1346-9843 ）

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.1253/circj.CJ-11-0364

  • Targeted Proteomics of Isolated Glomeruli from the Kidneys of Diabetic Rats: Sorbin and SH3 Domain Containing 2 Is a Novel Protein Associated with Diabetic Nephropathy Reviewed

    Nakatani Shinya, Kakehashi Anna, Ishimura Eiji, Yamano Shotaro, Mori Katsuhito, Wei Min, Inaba Masaaki, Wanibuchi Hideki

    EXPERIMENTAL DIABETES RESEARCH   2011   979354   2011（ ISSN:1687-5214 ）

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.1155/2011/979354

    PubMed

  • Targeted proteomics of isolated glomeruli from the kidneys of diabetic rats: sorbin and SH3 domain containing 2 is a novel protein associated with diabetic nephropathy.

    Nakatani S, Kakehashi A, Ishimura E, Yamano S, Mori K, Wei M, Inaba M, Wanibuchi H

    Experimental diabetes research   2011   979354   2011（ ISSN:1687-5214 ）

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  • A case of Legionella pneumonia associated with acute renal failure Reviewed

    NAKATANI Shinya, INARIBA Hiromi, KUMEDA Yasuo, INOUE Keisuke, SAI Yoshinori, OKAMURA Mikio, NISHIZAWA Yoshiki

    The Japanese Society for Dialysis Therapy, Nihon Toseki Igakkai Zasshi   43 ( 4 )   381 - 386   2010.04（ ISSN:13403451 ）

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    Publishing type：Research paper (scientific journal)  

    A 50-year-old man was admitted to our hospital with pyrexia of 38&deg;C and dyspnea. Chest X-ray film showed infiltration of the right lower field, and the serum creatinine was 4.01 mg/dL. We suspected atypical pneumonia, and cefozopran (CZOP) and minocycline (MINO) therapy was started. Although his general condition improved, renal function gradually deteriorated without an increase creatine phosphokinase level. On the 2nd hospital day, hemodialysis was started to treat acute renal failure. Renal function was improved after two hemodialysis sessions. On the 5th hospital day, a urinary <I>Legionella</I> antigen test proved positive ; consequently, the antibiotic therapy was switched to ciprofloxacin (CPFX) and MINO. Finally, on the 12th hospital day, the patient was discharged from our hospital without renal dysfunction. Rhabdomyolysis is often seen in certain cases of <I>Legionella</I> pneumonia associated with acute renal failure. However, in the present case, the patient's creatine phosphokinase level was normal ; therefore, rhabdomyolysis was not the cause of the observed acute renal failure. We consider that endotoxemia, direct microbial toxicity, inflammatory cytokines, or NSAIDS could have caused this patient's acute renal failure.

    DOI： 10.4009/jsdt.43.381

    CiNii Research

  • 急性腎不全を併発したレジオネラ肺炎の1例 Reviewed

    仲谷 慎也, 稲荷場 ひろみ, 久米田 靖郎, 井上 圭右, 崔 吉永, 岡村 幹夫, 西沢 良記

    (一社)日本透析医学会　日本透析医学会雑誌   43 ( 4 )   381 - 386   2010.04（ ISSN:1340-3451 ）

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    Publishing type：Research paper (scientific journal)  

    発熱、呼吸困難感を主訴とする50歳男性症例について検討した。セフカペンピボキシル(CFPN)・ロキソプロフェン投与による改善はみられなかった。胸部X線写真で右下肺野の浸潤影を認め、白血球数(WBC):12500/μl、C反応性蛋白(CRP):39.9mg/dl、クレアチニン(Cr):4.01mg/dlであった。肺炎および急性腎不全と診断し、異型肺炎の可能性を考慮してセフォゾプラン(CZOP)・ミノサイクリン(MINO)の投与を開始した。炎症反応は徐々に改善したが、腎機能障害は進行し、血液透析を2回行った。また、入院時の検体から尿中レジオネラ抗原陽性が判明した。急性腎不全を併発したレジオネラ肺炎と診断し、抗生剤をシプロフロキサシン(CPFX)・MINOに変更した。その後の経過は良好で、炎症反応・腎機能ともに著明に改善した。この症例の急性腎不全の原因にはレジオネラ菌の直接的な腎毒性・炎症性サイトカインの関与・入院前の非ステロイド性抗炎症薬(NSAIDS)の使用等が総合的に関与した可能性が高いと考えられた。

  • 急性腎不全を併発したレジオネラ肺炎の1例

    仲谷 慎也, 稲荷場 ひろみ, 久米田 靖郎, 井上 圭右, 崔 吉永, 岡村 幹夫, 西沢 良記

    日本透析医学会雑誌   43 ( 4 )   381 - 386   2010.04（ ISSN:1340-3451 ）

    　More details

    発熱、呼吸困難感を主訴とする50歳男性症例について検討した。セフカペンピボキシル(CFPN)・ロキソプロフェン投与による改善はみられなかった。胸部X線写真で右下肺野の浸潤影を認め、白血球数(WBC):12500/μl、C反応性蛋白(CRP):39.9mg/dl、クレアチニン(Cr):4.01mg/dlであった。肺炎および急性腎不全と診断し、異型肺炎の可能性を考慮してセフォゾプラン(CZOP)・ミノサイクリン(MINO)の投与を開始した。炎症反応は徐々に改善したが、腎機能障害は進行し、血液透析を2回行った。また、入院時の検体から尿中レジオネラ抗原陽性が判明した。急性腎不全を併発したレジオネラ肺炎と診断し、抗生剤をシプロフロキサシン(CPFX)・MINOに変更した。その後の経過は良好で、炎症反応・腎機能ともに著明に改善した。この症例の急性腎不全の原因にはレジオネラ菌の直接的な腎毒性・炎症性サイトカインの関与・入院前の非ステロイド性抗炎症薬(NSAIDS)の使用等が総合的に関与した可能性が高いと考えられた。

  • A case of Legionella pneumonia associated with acute renal failure

    Nakatani Shinya, Inariba Hiromi, Kumeda Yasuo, Inoue Keisuke, Sai Yoshinori, Okamura Mikio, Nishizawa Yoshiki

    Nihon Toseki Igakkai Zasshi   43 ( 4 )   381 - 386   2010（ ISSN:13403451 ） （ eISSN:1883082X ）

    　More details

    A 50-year-old man was admitted to our hospital with pyrexia of 38°C and dyspnea. Chest X-ray film showed infiltration of the right lower field, and the serum creatinine was 4.01 mg/dL. We suspected atypical pneumonia, and cefozopran (CZOP) and minocycline (MINO) therapy was started. Although his general condition improved, renal function gradually deteriorated without an increase creatine phosphokinase level. On the 2nd hospital day, hemodialysis was started to treat acute renal failure. Renal function was improved after two hemodialysis sessions. On the 5th hospital day, a urinary <I>Legionella</I> antigen test proved positive ; consequently, the antibiotic therapy was switched to ciprofloxacin (CPFX) and MINO. Finally, on the 12th hospital day, the patient was discharged from our hospital without renal dysfunction. Rhabdomyolysis is often seen in certain cases of <I>Legionella</I> pneumonia associated with acute renal failure. However, in the present case, the patient's creatine phosphokinase level was normal ; therefore, rhabdomyolysis was not the cause of the observed acute renal failure. We consider that endotoxemia, direct microbial toxicity, inflammatory cytokines, or NSAIDS could have caused this patient's acute renal failure.

    DOI： 10.4009/jsdt.43.381

    CiNii Research

  • Comparison of the Effect of BCAA Granules on Between Decompensated and Compensated Cirrhosis Reviewed

    Habu Daiki, Nishiguchi Shuhei, Nakatani Shinji, Lee Chulyoo, Enomoto Masaru, Tamori Akihiro, Takeda Tadashi, Ohfuji Satoko, Fukushima Wakaba, Tanaka Takashi, Kawamura Etsuji, Shiomi Susumu

    HEPATO-GASTROENTEROLOGY   56 ( 96 )   1719 - 1723   2009（ ISSN:0172-6390 ）

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    Publishing type：Research paper (scientific journal)  

  • Normal Values of Echocardiographic Parameters in Relation to Age in a Healthy Japanese Population-The JAMP Study- Reviewed

    Daimon Masao, Watanabe Hiroyuki, Abe Yukio, Hirata Kumiko, Hozumi Takeshi, Ishii Katsuhisa, Ito Hiroshi, Iwakura Katsuomi, Izumi Chisato, Matsuzaki Masunori, Minagoe Shinichi, Abe Haruhiko, Murata Kazuya, Nakatani Satoshi, Negishi Kazuaki, Yoshida Ken, Tanabe Kazuaki, Tanaka Nobuhiro, Tokai Kotaro, Yoshikawa Junichi

    CIRCULATION JOURNAL   72 ( 11 )   1859 - 1866   2008.11（ ISSN:1346-9843 ）

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    Publishing type：Research paper (scientific journal)  

  • 31) 冠動脈-肺動脈瘻に対して,外科的瘻孔閉鎖術・コイル塞栓術の併用が奏功した1例(第104回日本循環器学会近畿地方会) Reviewed

    仲谷 慎也, 片岡 亨, 高木 康浩, 浜中 裕子, 杉岡 憲一, 竹本 恭彦, 穂積 健之, 葭山 稔, 平居 秀和, 末廣 茂文

    社団法人日本循環器学会　Circulation journal : official journal of the Japanese Circulation Society   72 ( 0 )   2008.04（ ISSN:13469843 ）

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    Publishing type：Research paper (scientific journal)  

    CiNii Research

  • 31) 冠動脈-肺動脈瘻に対して,外科的瘻孔閉鎖術・コイル塞栓術の併用が奏功した1例(第104回日本循環器学会近畿地方会)

    仲谷 慎也, 片岡 亨, 高木 康浩, 浜中 裕子, 杉岡 憲一, 竹本 恭彦, 穂積 健之, 葭山 稔, 平居 秀和, 末廣 茂文

    72 ( 0 )   986   2008.04（ ISSN:13469843 ）

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  • Ultrasonographic diagnosis of degree of chronic type C liver disease Reviewed

    Habu D, Nishiguchi S, Enomoto M, Nakatani S, Minamitani S, Tamori A, Sakaguchi H, Takeda T, Seki S, Ogami M, Asai H, Shiomi S

    HEPATO-GASTROENTEROLOGY   52 ( 66 )   1820 - 1824   2005（ ISSN:0172-6390 ）

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    Publishing type：Research paper (scientific journal)  

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Books and Other Publications

  • CKD診療ガイド2024

    東京医学社  2024.07 

  • 腎不全 治療選択とその実際 2024年版

    （ Role： Joint editor）

    2024.01 

  • エビデンスに基づくCKD診療ガイドライン2023

    （ Role： Contributor）

    東京医学社  2023.06 

  • 腎不全 治療選択とその実際 2023年版

    （ Role： Joint editor）

    2023.01 

  • エビデンスに基づく多発性囊胞腎(PKD)診療ガイドライン2020

    （ Role： Contributor）

    東京医学社  2020.08 

  • エビデンスに基づく多発性嚢胞腎（PKD)診療ガイドライン2020

    難治性腎障害に関する調査研究班  （ Role： Joint author）

    東京医学者  2020.06 

  • 患者さんとご家族のための多発性嚢胞腎（PKD）療養ガイド .

    難治性腎障害に関する調査研究班     患者さんとご家族のための多発性嚢胞腎(PKD)療養ガイド編集委員会（ Role： Joint author）

    ライフサイエンス社会  2019.04 

  • 実臨床に即した腎炎・ネフローゼ症候群診療の入門書 : これから腎臓診療を行うひとのために

    石村 栄治, 仲谷 慎也, 阪口 勝彦（ Role： Sole author）

    医薬ジャーナル社  2018  （ ISBN:9784753228577 ）

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    Book type：Scholarly book

    CiNii Research

  • 実臨床に即した腎炎・ネフローゼ症候群診療の入門書

    石村栄治, 仲谷慎也, 阪口勝彦（ Role： Sole author）

    医薬ジャーナル社  2018 

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    Total pages：125   Responsible for pages：40   Book type：Scholarly book

  • 実臨床に即した腎炎・ネフローゼ症候群診療の入門書

    石村栄治、仲谷慎也、阪口勝彦（ Role： Joint author）

    医薬ジャーナル社  2018 

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    Total pages：125   Responsible for pages：40  

  • 実臨床に即した腎炎・ネフローゼ症候群診療の入門書 : これから腎臓診療を行うひとのために

    石村 栄治, 仲谷 慎也, 阪口 勝彦

    医薬ジャーナル社  2018  （ ISBN:9784753228577 ）

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  • 実臨床に即した腎炎・ネフローゼ症候群診療の入門書

    石村栄治, 仲谷慎也, 阪口勝彦（ Role： Joint author）

    医薬ジャーナル社  2018 

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    Total pages：125   Responsible for pages：40  

  • Phosphate and vitamin D in chronic kidney disease

    Razzaque Mohammed S.（ Role： Sole author）

    Karger  2013  （ ISBN:9783318023695 ）

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    Book type：Scholarly book

    CiNii Research

  • Phosphate and vitamin D in chronic kidney disease

    Razzaque Mohammed S.

    Karger  2013  （ ISBN:9783318023695 ）

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  • Criminals and their scientists : the history of criminology in international perspective

    Becker Peter, Wetzell Richard F.（ Role： Sole author）

    German Historical Institute  2006  （ ISBN:0521810124 ）

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    Book type：Scholarly book

    CiNii Research

  • Criminals and their scientists : the history of criminology in international perspective

    Becker Peter, Wetzell Richard F.

    German Historical Institute  2006  （ ISBN:0521810124 ）

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MISC

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Presentations

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Grant-in-Aid for Scientific Research

  • Phosphate toxicity as a factor which promotes aging in kidney failure patients undergoing hemodialysis

    Grant-in-Aid for Scientific Research(C)  2024

Charge of on-campus class subject

  • 代謝内分泌病態内科学（基礎研究-演習）

    2025   Intensive lecture   Graduate school

  • 代謝内分泌病態内科学（臨床研究-演習）

    2025   Intensive lecture   Graduate school

  • 代謝内分泌病態内科学（糖尿病代謝学-特論）

    2025   Intensive lecture   Graduate school

  • 腎臓病態内科学（臨床研究-演習）

    2025   Intensive lecture   Graduate school

  • 腎臓病態内科学（病理・診断・治療セミナー）

    2025   Intensive lecture   Graduate school

  • 腎臓病態内科学（腎臓学-総論）

    2025   Intensive lecture   Graduate school

  • 腎臓内科

    2020     Undergraduate

  • 腎臓内科

    2019     Undergraduate

  • 腎臓内科

    2018     Undergraduate

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Social Activities　⇒ Link to the list of Social Activities

  • 難病患者療養相談会

    Role(s)： Consultant

    2025.08

  • 難病患者療養相談会

    Role(s)： Consultant

    2024.09

  • 多発性嚢胞腎協会 医療従事者認定

    Role(s)： Logistic support

    2024.09

  • 多発性嚢胞腎協会 第３回zoom講演会

    Role(s)： Lecturer

    多発性嚢胞腎協会  2023.05

  • 難病患者療養相談会

    Role(s)： Consultant

    2023

  • 難病患者療養相談会

    Role(s)： Consultant

    2022

  • 常染色体優性多発性嚢胞腎に関して

    Role(s)： Lecturer

    Type： Lecture

    2018.04 - 2019.03

    　More details

    Audience： Researchesrs

    ADPKDに対する講演会を各地で行った

  • 常染色体優性多発性嚢胞腎に関して

    Role(s)： Lecturer

    Type： Lecture

    2018.04 - 2019.03

    　More details

    Audience： Researchesrs

    ADPKDに対する講演会を各地で行った

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