Updated on 2024/10/01

写真a

 
SUZUKI Shugo
 
Organization
Graduate School of Medicine Department of Basic Medical Science Professor
School of Medicine Department of Medical Science
Title
Professor
Affiliation
Institute of Medicine
Affiliation campus
Abeno Campus

Position

  • Graduate School of Medicine Department of Basic Medical Science 

    Professor  2024.10 - Now

  • Graduate School of Medicine Department of Basic Medical Science 

    Associate Professor  2022.04 - 2024.09

  • School of Medicine Department of Medical Science 

    Professor  2024.10 - Now

  • School of Medicine Department of Medical Science 

    Associate Professor  2022.04 - 2024.09

Degree

  • 博士(医学) ( Nagoya City University )

  • 学士(医学) ( Nagoya City University )

Research Areas

  • Life Science / Human pathology

  • Life Science / Experimental pathology

Research Interests

  • Pathology

  • Carcinogenesis

  • Prostate

  • Urinary bladder

Research subject summary

  • 環境に存在する化学物質の発がん性を検証するとともに、その発がん機序を解明する。動物実験による証明や機序解明、ヒト病理組織検体などを用いたヒトへの外挿を志す。また、発がん機序解明から、その発がん予防やがん治療への応用を考える。

Research Career

  • 化学発がん

    発がん機序、発がんリスク評価  Joint Research in Organization

    1999.04 - Now 

  • 膀胱癌研究

    環境発がん、リスク評価、発がん機序  International Joint Research

    2007.06 - Now 

  • 前立腺癌研究

    ヒト前立腺組織、発がんモデル  Joint Research in Organization

    1999.04 - Now 

Professional Memberships

  • 日本病理学会

      Domestic

  • 日本臨床細胞学会

      Domestic

  • 日本毒性病理学会

      Domestic

  • 日本癌学会

      Domestic

  • 日本毒性学会

      Domestic

  • トキシコロジー学会(Society of Toxicology)

      Overseas

  • 日本がん予防学会

      Domestic

  • 日本泌尿器病理研究会

  • 日本ヒ素研究会

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Committee Memberships (off-campus)

  • Editorial Board Member   Biomedical Science and Clinical Medicine (BSCM)  

    2022.03 - Now 

  • Associate Editor   Journal of Toxicologic Pathology  

    2022.01 - Now 

  • TGX Biomarkers for Genetic Toxicity   International Workshops on Genotoxicity Testing  

    2021.06 - 2022.08 

  • 委員   日本病理学会・Pathology International刊行委員会  

    2019.04 - Now 

  • 委員   日本毒性病理学会・教育委員会  

    2019.04 - Now 

Awards

  • 日本病理学会学術研究賞

    2023.11   日本病理学会   環境中の膀胱発がん物質検証と代謝を基盤とした発がん機序の解明

  • 平成30年度名古屋市立大学医学会奨励賞

    2018.12  

  • 第27回日本毒性病理学会総会及び学術集会 年会長賞 優秀賞

    2011.01  

  • 第16回前立腺がんワークショップ医学賞受賞

    2005.09  

Job Career (off-campus)

  • 名古屋市立大学大学院医学研究科   実験病態病理学   講師

    2017.10 - 2019.03

  • 名古屋市立東部医療センター   病理診断科   部長

    2012.04 - 2017.09

  • 名古屋市立東部医療センター   病理診断科   副部長

    2009.07 - 2012.03

  • University of Nebraska Medical Center   Pathology and Microbiology   Postdoctoral Research Associate

    2007.06 - 2009.06

  • 名古屋市立厚生院附属病院   病理部   副部長

    2006.04 - 2007.05

  • 名古屋市立大学大学院医学研究科   実験病態病理学   助手

    2003.04 - 2006.03

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Education

  • Nagoya City University   Doctor's Course   Graduated/Completed

    1999.04 - 2003.03

  • Nagoya City University     Graduated/Completed

    1993.04 - 1999.03

Papers

  • Characterizing the toxicological responses to inorganic arsenicals and their metabolites in immortalized human bladder epithelial cells. Reviewed

    Vachiraarunwong A, Gi M, Kiyono T, Suzuki S, Fujioka M, Qiu G, Guo R, Yamamoto T, Kakehashi A, Shiota M, Wanibuchi H

    Archives of toxicology   98 ( 7 )   2065 - 2084   2024.07( ISSN:0340-5761

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00204-024-03750-1

    PubMed

  • A novel support vector machine-based 1-day, single-dose prediction model of genotoxic hepatocarcinogenicity in rats. Reviewed

    Gi M, Suzuki S, Kanki M, Yokohira M, Tsukamoto T, Fujioka M, Vachiraarunwong A, Qiu G, Guo R, Wanibuchi H

    Archives of toxicology   2024.05( ISSN:0340-5761

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00204-024-03755-w

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  • Evaluation of the Mechanisms Involved in the Development of Bladder Toxicity following Exposure to Occupational Bladder Cancer Causative Chemicals Using DNA Adductome Analysis. Reviewed

    Suzuki S, Gi M, Komiya M, Obikane A, Vachiraarunwong A, Fujioka M, Kakehashi A, Totsuka Y, Wanibuchi H

    Biomolecules   14 ( 1 )   36   2024.01

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    Authorship:Lead author   Publishing type:Research paper (scientific journal)   International / domestic magazine:International journal  

    DOI: 10.3390/biom14010036

    PubMed

  • 中高年のサプリメント摂取によって起こるカルシウム過剰摂取が老人性認知症に及ぼす影響 Reviewed

    吉田 香, 魏 民, 鈴木 周五, 藤岡 正喜, 長谷川 千尋, 中川 歩, 南 美帆, 寺本 勲

    微量栄養素研究   40   70 - 76   2023.12( ISSN:1346-2334

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  • DNA Methylation Aberrations in Dimethylarsinic Acid-Induced Bladder Carcinogenesis. Reviewed

    Yamamoto T, Gi M, Yamashita S, Suzuki S, Fujioka M, Vachiraarunwong A, Guo R, Qiu G, Kakehashi A, Kato M, Uchida J, Wanibuchi H

    Cancers   15 ( 21 )   2023.11( ISSN:2072-6694

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.3390/cancers15215274

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  • Recent Insights into the Biomarkers, Molecular Targets and Mechanisms of Non-Alcoholic Steatohepatitis-Driven Hepatocarcinogenesis. Reviewed

    Kakehashi A, Suzuki S, Wanibuchi H

    Cancers   15 ( 18 )   2023.09( ISSN:2072-6694

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.3390/cancers15184566

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  • Dimethylarsinic acid induces bladder carcinogenesis via the amphiregulin pathway. Reviewed

    Suzuki S, Gi M, Fujioka M, Kakehashi A, Wanibuchi H

    Toxicology letters   384   128 - 135   2023.08( ISSN:0378-4274

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    Authorship:Lead author   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.toxlet.2023.08.004

    PubMed

  • o-Toluidine metabolism and effects in the urinary bladder of humanized-liver mice. Reviewed

    Yokota Y, Suzuki S, Gi M, Yanagiba Y, Yoneda N, Fujioka M, Kakehashi A, Koda S, Suemizu H, Wanibuchi H

    Toxicology   488   153483   2023.04( ISSN:0300-483X

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.tox.2023.153483

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  • A carcinogenicity study of diphenylarsinic acid in C57BL/6J mice in drinking water for 78 weeks Reviewed

    Yamaguchi Takashi, Gi Min, Fujioka Masaki, Suzuki Shugo, Oishi Yuji, Wanibuchi Hideki

    Journal of Toxicologic Pathology   36 ( 2 )   123 - 129   2023.04( ISSN:0914-9198 ( eISSN:1881915X

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    <p> Diphenylarsinic acid (DPAA), a neurotoxic organic arsenical, is present in groundwater and soil in some regions of Japan owing to illegal dumping. The present study evaluated the potential carcinogenicity of DPAA, including investigating whether bile duct hyperplasia in the liver that was observed in a chronic study on 52 week mouse, develops into a tumor when administered to mice in their drinking water for 78 weeks. DPAA was administered to 4 groups of male and female C57BL/6J mice at concentrations of 0, 6.25, 12.5, and 25 ppm in drinking water for 78 weeks. A significant decrease in the survival rate was found for females in the 25 ppm DPAA group. Body weights of males in the 25 ppm and females in the 12.5 and 25 ppm DPAA groups were significantly lower than those of the controls. Histopathological evaluation of neoplasms in all tissues showed no significant increase in tumor incidence in any organ or tissue of 6.25, 12.5, or 25 ppm DPAA-treated male or female mice. In conclusion, the present study demonstrated that DPAA is not carcinogenic to male or female C57BL/6J mice. Taken together with the fact that the toxic effect of DPAA is predominantly restricted to the central nervous system in humans, and the finding that DPAA was not carcinogenic in a previous 104-week rat carcinogenicity study, our results suggest that DPAA is unlikely to be carcinogenic in humans.</p>

    DOI: 10.1293/tox.2022-0111

    PubMed

  • Response biomarkers of inhalation exposure to cigarette smoke in the mouse lung Reviewed

    Suzuki Shugo, Asai Kazuhisa, Gi Min, Kojima Kazuya, Kakehashi Anna, Oishi Yuji, Matsue Taisuke, Yukimatsu Nao, Hirata Kazuto, Kawaguchi Tomoya, Wanibuchi Hideki

    Journal of Toxicologic Pathology   35 ( 3 )   247 - 254   2022.07( ISSN:0914-9198 ( eISSN:1881915X

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    <p> Cigarette smoking is known to increase the risk of cancer and chronic obstructive pulmonary disease (COPD). In this study, we evaluated the effects of short-term nose-only inhalation exposure to cigarette smoke in mice. Male 10-week-old C57BL mice were exposed to clean air (control) or mainstream cigarette smoke for 1 h/day, 5 days/week, for 2 or 4 weeks. Exposure to cigarette smoke increased the number of inflammatory cells, especially neutrophils, in the bronchoalveolar lavage fluid, increased inflammatory cell infiltration foci, and caused an increase in the thickness of the peripheral bronchial epithelium. Microarray gene expression analysis indicated that smoke exposure induced inflammatory responses, including leukocyte migration and activation of phagocytes and myeloid cells, as early as two weeks after the initiation of exposure. Importantly, chemokine (C-C motif) ligand 17, resistin-like alpha, and lipocalin 2 were upregulated and may serve as useful markers of the toxic effects of exposure to cigarette smoke before pulmonary histological changes become evident.</p>

    DOI: 10.1293/tox.2021-0077

    PubMed

  • Clinical relevance of tertiary lymphoid structures in esophageal squamous cell carcinoma. Reviewed

    Deguchi S, Tanaka H, Suzuki S, Natsuki S, Mori T, Miki Y, Yoshii M, Tamura T, Toyokawa T, Lee S, Muguruma K, Wanibuchi H, Ohira M

    BMC cancer   22 ( 1 )   699   2022.06

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s12885-022-09777-w

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  • The carbonic anhydrase inhibitor acetazolamide inhibits urinary bladder cancers via suppression of β-catenin signaling. Reviewed

    Matsue T, Gi M, Shiota M, Tachibana H, Suzuki S, Fujioka M, Kakehashi A, Yamamoto T, Kato M, Uchida J, Wanibuchi H

    Cancer science   2022.06( ISSN:1347-9032

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/cas.15467

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  • Persistent elevation of lysophosphatidylcholine promotes radiation brain necrosis with microglial recruitment by P2RX4 activation. Reviewed

    Kondo N, Sakurai Y, Takata T, Kano K, Kume K, Maeda M, Takai N, Suzuki S, Eto F, Kikushima K, Wanibuchi H, Miyatake SI, Kajihara T, Oda S, Setou M, Aoki J, Suzuki M

    Scientific reports   12 ( 1 )   8718   2022.05

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41598-022-12293-3

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  • Assessment of the toxicity and carcinogenicity of double-walled carbon nanotubes in the rat lung after intratracheal instillation: a two-year study. Reviewed

    Saleh DM, Luo S, Ahmed OHM, Alexander DB, Alexander WT, Gunasekaran S, El-Gazzar AM, Abdelgied M, Numano T, Takase H, Ohnishi M, Tomono S, Hady RHAE, Fukamachi K, Kanno J, Hirose A, Xu J, Suzuki S, Naiki-Ito A, Takahashi S, Tsuda H

    Particle and fibre toxicology   19 ( 1 )   30   2022.04

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s12989-022-00469-8

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  • Interplay between protein acetylation and ubiquitination controls MCL1 protein stability. Reviewed

    Shimizu K, Gi M, Suzuki S, North BJ, Watahiki A, Fukumoto S, Asara JM, Tokunaga F, Wei W, Inuzuka H

    Cell reports   37 ( 6 )   109988   2021.11

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.celrep.2021.109988

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  • Selective extension of cerebral vascular calcification in an autopsy case of Fahr's syndrome associated with asymptomatic hypoparathyroidism. Reviewed

    Iwase T, Yoshida M, Iwasaki Y, Suzuki S, Yabata H, Koizumi R, Moriyoshi H, Yazawa I

    Neuropathology : official journal of the Japanese Society of Neuropathology   41 ( 5 )   387 - 395   2021.10( ISSN:0919-6544

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/neup.12760

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  • Canopy Homolog 2 as a Novel Molecular Target in Hepatocarcinogenesis. Reviewed

    Kakehashi A, Suzuki S, Shiota M, Raymo N, Gi M, Tachibana T, Stefanov V, Wanibuchi H

    Cancers   13 ( 14 )   2021.07

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.3390/cancers13143613

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  • Tertiary lymphoid structures show infiltration of effective tumor-resident T cells in gastric cancer. Reviewed

    Mori T, Tanaka H, Suzuki S, Deguchi S, Yamakoshi Y, Yoshii M, Miki Y, Tamura T, Toyokawa T, Lee S, Muguruma K, Wanibuchi H, Ohira M

    Cancer science   2021.03( ISSN:1347-9032

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/cas.14888

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  • Cache Domain Containing 1 Is a Novel Marker of Non-Alcoholic Steatohepatitis-Associated Hepatocarcinogenesis. Reviewed

    Kakehashi A, Chariyakornkul A, Suzuki S, Khuanphram N, Tatsumi K, Yamano S, Fujioka M, Gi M, Wongpoomchai R, Wanibuchi H

    Cancers   13 ( 6 )   2021.03

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.3390/cancers13061216

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  • DPYD, down-regulated by the potentially chemopreventive agent luteolin, interacts with STAT3 in pancreatic cancer. Reviewed

    Kato H, Naiki-Ito A, Suzuki S, Inaguma S, Komura M, Nakao K, Naiki T, Kachi K, Kato A, Matsuo Y, Takahashi S

    Carcinogenesis   2021.02( ISSN:0143-3334

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/carcin/bgab017

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  • Cell proliferation of rat bladder urothelium induced by nicotine is suppressed by the NADPH oxidase inhibitor, apocynin. Reviewed

    Suzuki S, Cohen SM, Arnold LL, Pennington KL, Gi M, Kato H, Naiki T, Naiki-Ito A, Wanibuchi H, Takahashi S

    Toxicology letters   336   32 - 38   2021( ISSN:0378-4274

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.toxlet.2020.11.005

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  • The standard form of CD44 as a marker for invasion of encapsulated papillary carcinoma of the breast Reviewed

    Kato Hiroyuki, Naiki-Ito Aya, Yamada Takehiro, Suzuki Shugo, Yamashita Yoriko, Inaguma Shingo, Kondo Naoto, Wanifuchi-Endo Yumi, Toyama Tatsuya, Takahashi Satoru

    Pathology International   70 ( 11 )   835 - 843   2020.11( ISSN:1320-5463

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  • Accumulation of 8-hydroxydeoxyguanosine, L-arginine and Glucose Metabolites by Liver Tumor Cells Are the Important Characteristic Features of Metabolic Syndrome and Non-Alcoholic Steatohepatitis-Associated Hepatocarcinogenesis. Reviewed

    Kakehashi A, Suzuki S, Ishii N, Okuno T, Kuwae Y, Fujioka M, Gi M, Stefanov V, Wanibuchi H

    International journal of molecular sciences   21 ( 20 )   2020.10

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.3390/ijms21207746

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  • Role of γ-H2AX as a biomarker for detection of bladder carcinogens in F344 rats. Reviewed

    Suzuki S, Gi M, Toyoda T, Kato H, Naiki-Ito A, Kakehashi A, Ogawa K, Takahashi S, Wanibuchi H

    Journal of toxicologic pathology   33 ( 4 )   279 - 285   2020.10( ISSN:0914-9198

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    <p> Phosphorylation of histone H2AX at serine 139 (γ-H2AX) is known to be induced by direct DNA damage or cellular metabolic imbalances and malfunctions. Previous studies have reported that γ-H2AX is a useful biomarker for early detection of genotoxic bladder carcinogens in rats. The purpose of the present study was to determine the role of γ-H2AX as a biomarker for detection of non-genotoxic bladder carcinogens in rats. Six-week-old male F344 rats were treated with 15 different chemicals for 4 weeks. Immunohistochemical analyses revealed that all three genotoxic bladder carcinogens and six out of seven non-genotoxic bladder carcinogens significantly increased γ-H2AX formation in the bladder urothelium of rats. In addition, four out of five rat bladder noncarcinogens did not increase γ-H2AX formation in the bladder urothelium regardless of genotoxicity. These results suggest that γ-H2AX is a useful biomarker for detection of both genotoxic and non-genotoxic bladder carcinogens in rats.</p>

    DOI: 10.1293/tox.2020-0038

    PubMed

    CiNii Article

  • A novel model of non-alcoholic steatohepatitis with fibrosis and carcinogenesis in connexin 32 dominant-negative transgenic rats. Reviewed

    Naiki-Ito A, Kato H, Naiki T, Yeewa R, Aoyama Y, Nagayasu Y, Suzuki S, Inaguma S, Takahashi S

    Archives of toxicology   94 ( 12 )   4085 - 4097   2020.08( ISSN:0340-5761

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    Non-alcoholic steatohepatitis (NASH) is a recognized risk factor for liver fibrosis and malignancies, and is associated with features of metabolic syndrome, such as obesity and insulin resistance (IR). We previously demonstrated that the disturbance of connexin 32 (Cx32), a gap junctional protein of hepatocytes, exacerbated NASH in Cx32 dominant-negative transgenic (Cx32ΔTg) rats fed methionine choline-deficient diet (MCDD). MCDD is well-established means of inducing NASH in rodents; however, the Cx32ΔTg-MCDD NASH model does not reproduce obesity and IR. In this study, we aimed to establish an improved NASH model. Eight-week-old male Cx32ΔTg and wild-type (Wt) rats received a high-fat diet (HFD) with dimethylnitrosamine (DMN) for 12 weeks. The HFD with DMN led to gains in body, liver, and visceral fat weights in both genotypes. IR was significantly greater in Cx32ΔTg than in Wt rats. Elevation of serum hepatic enzymes (AST, ALT), inflammatory cytokine expressions (Tnfα, Il-6, Tgf-β1, Il-1β, Timp2, and Col1a1), steatohepatitis, and fibrosis were significantly greater in Cx32ΔTg as compared with Wt rats. Regarding carcinogenesis, the number and area of glutathione S-transferase placental form (GST-P)-positive preneoplastic hepatic foci were significantly increased in Cx32ΔTg versus Wt rats. Moreover, activation of NF-κB and JNK contributed to the progression of NASH in Cx32ΔTg rats. These results suggest that Cx32 dysfunction promoted the progression of NASH, metabolic syndrome, and carcinogenesis. Therefore, the novel Cx32ΔTg-HFD-DMN NASH model may be a rapid and useful tool for evaluating the progression of NASH.

    DOI: 10.1007/s00204-020-02873-5

    PubMed

  • Dehydrozingerone, a Curcumin Analog, as a Potential Anti-Prostate Cancer Inhibitor In Vitro and In Vivo. Reviewed

    Mapoung S, Suzuki S, Fuji S, Naiki-Ito A, Kato H, Yodkeeree S, Sakorn N, Ovatlarnporn C, Takahashi S, Limtrakul Dejkriengkraikul P

    Molecules (Basel, Switzerland)   25 ( 12 )   2737   2020.06

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.3390/molecules25122737

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  • Hexane Insoluble Fraction from Purple Rice Extract Retards Carcinogenesis and Castration-Resistant Cancer Growth of Prostate Through Suppression of Androgen Receptor Mediated Cell Proliferation and Metabolism. Reviewed

    Yeewa R, Naiki-Ito A, Naiki T, Kato H, Suzuki S, Chewonarin T, Takahashi S

    Nutrients   12 ( 2 )   558   2020.02

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.3390/nu12020558

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  • Dimethylarsinic acid (DMA) enhanced lung carcinogenesis via histone H3K9 modification in a transplacental mouse model. Reviewed

    Fujioka M, Suzuki S, Gi M, Kakehashi A, Oishi Y, Okuno T, Yukimatsu N, Wanibuchi H

    Archives of toxicology   94 ( 3 )   927 - 937   2020.02( ISSN:0340-5761

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00204-020-02665-x

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  • Luteolin suppresses bladder cancer growth via regulation of mechanistic target of rapamycin pathway. Reviewed

    Iida K, Naiki T, Naiki-Ito A, Suzuki S, Kato H, Nozaki S, Nagai T, Etani T, Nagayasu Y, Ando R, Kawai N, Yasui T, Takahashi S

    Cancer science   111 ( 4 )   1165 - 1179   2020.01( ISSN:1347-9032

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/cas.14334

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  • Recruitment of miR-8080 by luteolin inhibits androgen receptor splice variant 7 expression in castration-resistant prostate cancer. Reviewed

    Naiki-Ito A, Naiki T, Kato H, Iida K, Etani T, Nagayasu Y, Suzuki S, Yamashita Y, Inaguma S, Onishi M, Tanaka Y, Yasui T, Takahashi S

    Carcinogenesis   41 ( 8 )   1145 - 1157   2019.12( ISSN:0143-3334

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/carcin/bgz193

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  • Cotinine, a major nicotine metabolite, induces cell proliferation on urothelium in vitro and in vivo. Reviewed

    Suzuki S, Cohen SM, Arnold LL, Pennington KL, Kato H, Naiki T, Naiki-Ito A, Yamashita Y, Takahashi S

    Toxicology   429   152325   2019.10( ISSN:0300-483X

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.tox.2019.152325

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  • Promotion effects of acetoaceto-o-toluidide on N-butyl-N-(4-hydroxybutyl)nitrosamine-induced bladder carcinogenesis in rats. Reviewed

    Yukimatsu N, Gi M, Okuno T, Fujioka M, Suzuki S, Kakehashi A, Yanagiba Y, Suda M, Koda S, Nakatani T, Wanibuchi H

    Archives of toxicology   93 ( 12 )   3617 - 3631   2019.10( ISSN:0340-5761

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00204-019-02605-4

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  • Epithelioid variant of gastrointestinal stromal tumor harboring PDGFRA mutation and MLH1 gene alteration: A case report. Reviewed

    Kobayashi M, Inaguma S, Raffeld M, Kato H, Suzuki S, Wakasugi T, Mitsui A, Kuwabara Y, Lasota J, Ikeda H, Miettinen M, Takahashi S

    Pathology international   69 ( 9 )   541 - 546   2019.09( ISSN:1320-5463

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/pin.12830

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  • MWCNT-7 administered to the lung by intratracheal instillation induces development of pleural mesothelioma in F344 rats Reviewed

    Numano T, Higuchi H, Alexander DB, Alexander WT, Abdelgied M, El-Gazzar AM, Saleh D, Takase H, Hirose A, Naiki-Ito A, Suzuki S, Takahashi S, Tsuda H

    Cancer Science   110 ( 8 )   2485 - 2492   2019.08( ISSN:1347-9032

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    Publishing type:Research paper (scientific journal)  

    © 2019 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association. Multi-walled carbon nanotube-7 (MWCNT-7) fibers are biopersistent and have a structure similar to asbestos. MWCNT-7 has been shown to induce malignant mesothelioma when administered by intrascrotal or intraperitoneal injection in rats and mice, and an inhalation study demonstrated that rats exposed to respirable MWCNT-7 developed lung tumors. MWCNT-N, which is similar to MWCNT-7, was shown to induce both lung tumors and malignant mesothelioma in rats when administered by trans-tracheal intrapulmonary spraying (TIPS). The present study was performed to investigate the carcinogenicity of MWCNT-7 when administered by the TIPS method. Ten-week-old male F344/Crj rats were divided into 3 groups and administered 0.5 mL vehicle, 0.250 μg/mL MWCNT-7 or 0.250 μg/mL crocidolite once a week for 12 weeks (total doses of 1.5 mg/rat) and then observed for up to 104 weeks. Rats in the MWCNT-7 group began to die from pathologies associated with the development of malignant mesothelioma 35 weeks after the final TIPS administration. Overall, the incidence of malignant mesothelioma in the MWCNT-7 group was significantly higher than in the vehicle or crocidolite groups.

    DOI: 10.1111/cas.14121

    PubMed

  • Dimethylarsinic acid may promote prostate carcinogenesis in rats. Reviewed

    Suzuki S, Toyoda T, Kato H, Naiki-Ito A, Yamashita Y, Akagi JI, Cho YM, Ogawa K, Takahashi S

    Journal of toxicologic pathology   32 ( 2 )   73 - 77   2019.04( ISSN:0914-9198

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    DOI: 10.1293/tox.2018-0050

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  • Short-term detection of gastric genotoxicity using the DNA double-strand break marker γ-H2AX. Reviewed

    Okabe A, Kiriyama Y, Suzuki S, Sakurai K, Teramoto A, Kato H, Naiki-Ito A, Tahara S, Takahashi S, Kuroda M, Sugioka A, Tsukamoto T

    Journal of toxicologic pathology   32 ( 2 )   91 - 99   2019.04( ISSN:0914-9198

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    DOI: 10.1293/tox.2019-0007

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  • NCL1, A Highly Selective Lysine-Specific Demethylase 1 Inhibitor, Suppresses Castration-Resistant Prostate Cancer Growth via Regulation of Apoptosis and Autophagy. Reviewed

    Etani T, Naiki T, Naiki-Ito A, Suzuki T, Iida K, Nozaki S, Kato H, Nagayasu Y, Suzuki S, Kawai N, Yasui T, Takahashi S

    Journal of clinical medicine   8 ( 4 )   2019.03

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    DOI: 10.3390/jcm8040442

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  • Cyclohexanone curcumin analogs inhibit the progression of castration-resistant prostate cancer in vitro and in vivo. Reviewed

    Mapoung S, Suzuki S, Fuji S, Naiki-Ito A, Kato H, Yodkeeree S, Ovatlarnporn C, Takahashi S, Limtrakul Dejkriengkraikul P

    Cancer science   110 ( 2 )   596 - 607   2019.02( ISSN:1347-9032

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    DOI: 10.1111/cas.13897

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  • Preventive Effects of Fermented Brown Rice and Rice Bran on Spontaneous Lymphomagenesis in AKR/NSlc Female Mice Reviewed

    Kuno T, Kato H, Naiki-Ito A, Suzuki S, Tanaka T, Takahashi S, Mori H

    Asian Pacific journal of cancer prevention : APJCP   19 ( 11 )   3217 - 3223   2018.11( ISSN:1513-7368

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    DOI: 10.31557/APJCP.2018.19.11.3217

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  • 心アミロイドーシスと十二指腸乳頭部癌を合併した一例 Reviewed

    中谷 優子, 佐伯 知昭, 溝口 達也, 野田 翼, 蓮尾 隆博, 関本 暁, 吉田 孝幸, 玉井 希, 村上 善正, 鈴木 周五

    名古屋市病院局 名古屋市立病院紀要   40   53 - 57   2018.09( ISSN:0911-9809

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    85歳男性。難治性心不全に十二指腸乳頭部癌を合併し2回目の心臓カテーテル検査で心筋生検を行いAL型心アミロイドーシスと診断、心不全3年および十二指腸癌1年という緩徐な経過で心不全死された。難治性心不全のため抗がん剤の使用歴はない。病理解剖の結果、全身性AA型アミロイドーシスと診断することができた。(著者抄録)

  • Expression of P-REX2a is associated with poor prognosis in endometrial malignancies. Reviewed

    Takeshita S, Yamashita Y, Shiomi K, Suzuki N, Yoshida J, Naiki-Ito A, Suzuki S, Akatsuka S, Toyokuni S, Takahashi T, Mase S, Arakawa A, Sugiura-Ogasawara M, Takahashi S

    Oncotarget   9 ( 37 )   24778 - 24786   2018.05

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    DOI: 10.18632/oncotarget.25349

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  • Orally administered nicotine effects on rat urinary bladder proliferation and carcinogenesis. Reviewed

    Suzuki S, Cohen SM, Arnold LL, Kato H, Fuji S, Pennington KL, Nagayasu Y, Naiki-Ito A, Yamashita Y, Takahashi S

    Toxicology   398-399   31 - 40   2018.04( ISSN:0300-483X

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    DOI: 10.1016/j.tox.2018.02.008

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  • Association of genetic variants of <i>PD1</i> with recurrent pregnancy loss. Reviewed

    Hayashi Y, Nishiyama T, Nakatochi M, Suzuki S, Takahashi S, Sugiura-Ogasawara M

    Reproductive medicine and biology   17 ( 2 )   195 - 202   2018.04( ISSN:1445-5781

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    DOI: 10.1002/rmb2.12093

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  • GPX2 promotes development of bladder cancer with squamous cell differentiation through the control of apoptosis. Reviewed

    Naiki T, Naiki-Ito A, Iida K, Etani T, Kato H, Suzuki S, Yamashita Y, Kawai N, Yasui T, Takahashi S

    Oncotarget   9 ( 22 )   15847 - 15859   2018.03

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    DOI: 10.18632/oncotarget.24627

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  • Chemopreventive effects of angiotensin II receptor type 2 agonist on prostate carcinogenesis by the down-regulation of the androgen receptor. Reviewed

    Ito Y, Naiki-Ito A, Kato H, Suzuki S, Kuno T, Ishiguro Y, Takahashi S, Uemura H

    Oncotarget   9 ( 17 )   13859 - 13869   2018.03

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    DOI: 10.18632/oncotarget.24492

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  • Early detection of prostate carcinogens by immunohistochemistry of HMGB2. Reviewed

    Suzuki S, Kato H, Fuji S, Naiki T, Naiki-Ito A, Yamashita Y, Takahashi S

    The Journal of toxicological sciences   43 ( 6 )   359 - 367   2018( ISSN:0388-1350

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    DOI: 10.2131/jts.43.359

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  • Expression and subcellular localization of AT motif binding factor 1 in colon tumours. Reviewed

    Kataoka H, Miura Y, Kawaguchi M, Suzuki S, Okamoto Y, Ozeki K, Shimura T, Mizoshita T, Kubota E, Tanida S, Takahashi S, Asai K, Joh T

    Molecular medicine reports   16 ( 3 )   3095 - 3102   2017.09( ISSN:1791-2997

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    DOI: 10.3892/mmr.2017.7016

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  • アンジオテンシン2レセプターアゴニストのアンドロゲン受容体発現抑制による前立腺癌の化学予防効果 Reviewed

    上村 博司, 伊藤 悠亮, 内木 綾, 加藤 寛之, 鈴木 周五, 久野 壽也, 高橋 智

    医学図書出版(株) 泌尿器外科   30 ( 8 )   1221 - 1224   2017.08( ISSN:0914-6180

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    われわれは前立腺癌の発生や進展にレニン-アンジオテンシン系が関係しており、アンジオテンシン2のAT1受容体ブロッカーがアンドロゲン受容体(AR)発現抑制して抗腫瘍効果があることを示した。この研究では、アンジオテンシン2のもう一つの受容体であるAT2受容体が前立腺癌の発生に関わっているか調べた。その結果、AT2受容体アゴニストのC21がAR発現抑制によって前立腺癌の発生を抑制して、化学予防効果のあることが示された。(著者抄録)

  • The NADPH Oxidase Inhibitor Apocynin Suppresses Preneoplastic Liver Foci of Rats. Reviewed

    Fuji S, Suzuki S, Naiki-Ito A, Kato H, Hayakawa M, Yamashita Y, Kuno T, Takahashi S

    Toxicologic pathology   45 ( 4 )   544 - 550   2017.06( ISSN:0192-6233

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    DOI: 10.1177/0192623317710013

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  • 遺伝毒性膀胱発がん物質によるラット膀胱粘膜におけるγH2AX発現 Reviewed

    豊田 武士, 鈴木 周五, 加藤 寛之, 曽根 瑞季, 松下 幸平, Cho Young-Man, 赤木 純一, 井上 薫, 高橋 智, 西川 秋佳, 小川 久美子

    日本毒性病理学会 日本毒性病理学会講演要旨集   33回   91 - 91   2017.01

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  • Pioglitazone, a Peroxisome Proliferator-Activated Receptor γ Agonist, Suppresses Rat Prostate Carcinogenesis. Reviewed

    Suzuki S, Mori Y, Nagano A, Naiki-Ito A, Kato H, Nagayasu Y, Kobayashi M, Kuno T, Takahashi S

    International journal of molecular sciences   17 ( 12 )   2016.12

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    DOI: 10.3390/ijms17122071

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  • 急性汎発性発疹性膿疱症との鑑別を要したメキシレチン塩酸塩による薬剤性過敏症症候群の1例 Reviewed

    高木 佐千代, 加藤 愛, 苅谷 清徳, 鈴木 周五

    金原出版(株) 皮膚科の臨床   58 ( 11 )   1696 - 1701   2016.10( ISSN:0018-1404

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    69歳女性。メキシレチン塩酸塩内服開始約1ヵ月後より両上肢に皮疹が出現し近医を受診、接触性皮膚炎として抗アレルギー薬を処方されるも改善せず、皮疹が拡大したため、著者らの皮膚科へ紹介となった。初診時、体幹・四肢に多形紅斑を認め、3日後には皮疹が増悪し、全身倦怠感を伴ったため入院となった。入院時、両側腹部と大腿内側には暗赤色の紅斑上に粟粒大で毛孔不一致の小膿疱が散在し、膿疱は数日で消退したものの、紅斑は遷延した。経過中に発熱、リンパ節腫脹、好酸球の上昇、軽度の肝機能障害、ヒトヘルペスウイルス6型の再活性を認めたことから、本症例はメキシレチン塩酸塩による薬剤性過敏症症候群と診断された。治療としてメキシレチン塩酸塩の中止、プレドニゾロンの内服を行なったところ、紅斑は徐々に軽快し、経過良好であった。尚、本症例は発疹学的には急性汎発性発疹性膿疱症に近似しており、鑑別を要した。

  • Immunogenic cell death due to a new photodynamic therapy (PDT) with glycoconjugated chlorin (G-chlorin). Reviewed

    Tanaka M, Kataoka H, Yano S, Sawada T, Akashi H, Inoue M, Suzuki S, Inagaki Y, Hayashi N, Nishie H, Shimura T, Mizoshita T, Mori Y, Kubota E, Tanida S, Takahashi S, Joh T

    Oncotarget   7 ( 30 )   47242 - 47251   2016.07

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    DOI: 10.18632/oncotarget.9725

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  • Histone Deacetylase Inhibition in Prostate Cancer Triggers miR-320-Mediated Suppression of the Androgen Receptor. Reviewed

    Sato S, Katsushima K, Shinjo K, Hatanaka A, Ohka F, Suzuki S, Naiki-Ito A, Soga N, Takahashi S, Kondo Y

    Cancer research   76 ( 14 )   4192 - 204   2016.07( ISSN:0008-5472

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    DOI: 10.1158/0008-5472.CAN-15-3339

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  • Preventive Effects of Fermented Brown Rice and Rice Bran against Prostate Carcinogenesis in TRAP Rats. Reviewed

    Kuno T, Nagano A, Mori Y, Kato H, Nagayasu Y, Naiki-Ito A, Suzuki S, Mori H, Takahashi S

    Nutrients   8 ( 7 )   2016.07

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    DOI: 10.3390/nu8070421

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  • Connexin 32 dysfunction promotes ethanol-related hepatocarcinogenesis via activation of Dusp1-Erk axis. Reviewed

    Kato H, Naiki-Ito A, Naiki T, Suzuki S, Yamashita Y, Sato S, Sagawa H, Kato A, Kuno T, Takahashi S

    Oncotarget   7 ( 2 )   2009 - 21   2016.01

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    DOI: 10.18632/oncotarget.6511

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  • Chemopreventive effect of resveratrol and apocynin on pancreatic carcinogenesis via modulation of nuclear phosphorylated GSK3β and ERK1/2. Reviewed

    Kato A, Naiki-Ito A, Nakazawa T, Hayashi K, Naitoh I, Miyabe K, Shimizu S, Kondo H, Nishi Y, Yoshida M, Umemura S, Hori Y, Mori T, Tsutsumi M, Kuno T, Suzuki S, Kato H, Ohara H, Joh T, Takahashi S

    Oncotarget   6 ( 40 )   42963 - 75   2015.12

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    DOI: 10.18632/oncotarget.5981

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  • Connexin 32 and luteolin play protective roles in non-alcoholic steatohepatitis development and its related hepatocarcinogenesis in rats. Reviewed

    Sagawa H, Naiki-Ito A, Kato H, Naiki T, Yamashita Y, Suzuki S, Sato S, Shiomi K, Kato A, Kuno T, Matsuo Y, Kimura M, Takeyama H, Takahashi S

    Carcinogenesis   36 ( 12 )   1539 - 49   2015.12( ISSN:0143-3334

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    DOI: 10.1093/carcin/bgv143

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  • A novel photodynamic therapy targeting cancer cells and tumor-associated macrophages. Reviewed

    Hayashi N, Kataoka H, Yano S, Tanaka M, Moriwaki K, Akashi H, Suzuki S, Mori Y, Kubota E, Tanida S, Takahashi S, Joh T

    Molecular cancer therapeutics   14 ( 2 )   452 - 60   2015.02( ISSN:1535-7163

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    DOI: 10.1158/1535-7163.MCT-14-0348

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  • Establishment of a syngeneic orthotopic model of prostate cancer in immunocompetent rats. Reviewed

    Suzuki S, Naiki-Ito A, Kuno T, Punfa W, Long N, Kato H, Inaguma S, Komiya M, Shirai T, Takahashi S

    Journal of toxicologic pathology   28 ( 1 )   21 - 6   2015.01( ISSN:0914-9198

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    DOI: 10.1293/tox.2014-0050

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  • Napsin A is a specific marker for ovarian clear cell adenocarcinoma. Reviewed

    Yamashita Y, Nagasaka T, Naiki-Ito A, Sato S, Suzuki S, Toyokuni S, Ito M, Takahashi S

    Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc   28 ( 1 )   111 - 7   2015.01( ISSN:0893-3952

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    DOI: 10.1038/modpathol.2014.61

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  • GPX2 overexpression is involved in cell proliferation and prognosis of castration-resistant prostate cancer. Reviewed

    Naiki T, Naiki-Ito A, Asamoto M, Kawai N, Tozawa K, Etani T, Sato S, Suzuki S, Shirai T, Kohri K, Takahashi S

    Carcinogenesis   35 ( 9 )   1962 - 7   2014.09( ISSN:0143-3334

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    DOI: 10.1093/carcin/bgu048

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  • Time course of urothelial changes in rats and mice orally administered arsenite. Reviewed

    Arnold LL, Suzuki S, Yokohira M, Kakiuchi-Kiyota S, Pennington KL, Cohen SM

    Toxicologic pathology   42 ( 5 )   855 - 62   2014.07( ISSN:0192-6233

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    DOI: 10.1177/0192623313489778

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  • Establishment of an invasive prostate cancer model in transgenic rats by intermittent testosterone administration. Reviewed

    Sato S, Suzuki S, Naiki-Ito A, Komiya M, Ne L, Kato H, Sagawa H, Yamashita Y, Shirai T, Takahashi S

    Journal of toxicologic pathology   27 ( 1 )   43 - 9   2014.04( ISSN:0914-9198

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    DOI: 10.1293/tox.2013-0052

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  • Intravascular lymphomatosis mimicking primary central nervous system lymphoma: A case report and literature review Reviewed

    Masahiro Oomura, Noriyuki Sakakibara, Shugo Suzuki, Atsushi Wakita, Yuji Mori, Kaoru Kamimoto

    Case Reports in Neurology   6   101 - 108   2014.01

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    We herein report a 75-year-old female patient with intravascular lymphomatosis (IVL) who presented with fever of unknown origin. Examination, including contrast-enhanced CT and 67Ga scintigraphy, failed to show any lesions. Her blood levels of lactate dehydrogenase and soluble interleukin-2 receptors were high, suggesting a lymphomatous tumor. A bone marrow puncture was negative, and a random skin biopsy revealed a monoclonal proliferation of naked, large lymphocytes in the vascular space of the subcutaneous tissue, confirming the diagnosis of IVL. MRI, performed 7 weeks after admission, showed a brain mass mimicking primary central nervous system lymphoma. The mass was considered to be a collection of malignant lymphocyte cells invading from the vessels. Without the random skin biopsy, this case may have been misdiagnosed as primary central nervous system lymphoma. © 2014 S. Karger AG, Basel.

    DOI: 10.1159/000362121

  • Characterization of intracellular inclusions in the urothelium of mice exposed to inorganic arsenic. Reviewed

    Dodmane PR, Arnold LL, Muirhead DE, Suzuki S, Yokohira M, Pennington KL, Dave BJ, Lu X, Le XC, Cohen SM

    Toxicological sciences : an official journal of the Society of Toxicology   137 ( 1 )   36 - 46   2014.01( ISSN:1096-6080

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    DOI: 10.1093/toxsci/kft227

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  • A case of idiopathic giant cell myocarditis with a past history of sarcoidosis. Reviewed

    Nakasuka K, Ito S, Miyata K, Inomata M, Yoshida T, Tamai N, Suzuki S, Murakami Y, Sato K, Suzuki S, Eishi Y, Morimoto SI

    Journal of cardiology cases   9 ( 1 )   35 - 39   2014.01

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    DOI: 10.1016/j.jccase.2013.09.004

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  • Curcumin-loaded PLGA nanoparticles conjugated with anti- P-glycoprotein antibody to overcome multidrug resistance. Reviewed

    Punfa W, Suzuki S, Pitchakarn P, Yodkeeree S, Naiki T, Takahashi S, Limtrakul P

    Asian Pacific journal of cancer prevention : APJCP   15 ( 21 )   9249 - 58   2014( ISSN:1513-7368

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  • Double-valve replacement for mitral and aortic regurgitation in a Patient with Libman-Sacks endocarditis. Reviewed

    Hachiya K, Wakami K, Tani T, Yoshida A, Suzuki S, Suda H, Ohte N

    Internal medicine (Tokyo, Japan)   53 ( 16 )   1769 - 73   2014( ISSN:0918-2918

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  • IV injection of polystyrene beads for mouse model of sepsis causes severe glomerular injury. Reviewed

    Arima H, Hirate H, Sugiura T, Suzuki S, Takahashi S, Sobue K

    Journal of intensive care   2 ( 1 )   21   2014

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    DOI: 10.1186/2052-0492-2-21

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  • Apocynin, an NADPH oxidase inhibitor, suppresses rat prostate carcinogenesis. Reviewed

    Suzuki S, Shiraga K, Sato S, Punfa W, Naiki-Ito A, Yamashita Y, Shirai T, Takahashi S

    Cancer science   104 ( 12 )   1711 - 7   2013.12( ISSN:1347-9032

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    DOI: 10.1111/cas.12292

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  • Apocynin, an NADPH oxidase inhibitor, suppresses progression of prostate cancer via Rac1 dephosphorylation. Reviewed

    Suzuki S, Pitchakarn P, Sato S, Shirai T, Takahashi S

    Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie   65 ( 7-8 )   1035 - 41   2013.11( ISSN:0940-2993

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    DOI: 10.1016/j.etp.2013.03.002

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  • Elevated expression of coactivator-associated arginine methyltransferase 1 is associated with early hepatocarcinogenesis. Reviewed

    Osada S, Suzuki S, Yoshimi C, Matsumoto M, Shirai T, Takahashi S, Imagawa M

    Oncology reports   30 ( 4 )   1669 - 74   2013.10( ISSN:1021-335X

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    DOI: 10.3892/or.2013.2651

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  • Expression of glutathione peroxidase 2 is associated with not only early hepatocarcinogenesis but also late stage metastasis. Reviewed

    Suzuki S, Pitchakarn P, Ogawa K, Naiki-Ito A, Chewonarin T, Punfa W, Asamoto M, Shirai T, Takahashi S

    Toxicology   311 ( 3 )   115 - 23   2013.09( ISSN:0300-483X

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    DOI: 10.1016/j.tox.2013.07.005

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  • Purple corn color inhibition of prostate carcinogenesis by targeting cell growth pathways. Reviewed

    Long N, Suzuki S, Sato S, Naiki-Ito A, Sakatani K, Shirai T, Takahashi S

    Cancer science   104 ( 3 )   298 - 303   2013.03( ISSN:1347-9032

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    DOI: 10.1111/cas.12078

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  • Ellagic acid inhibits migration and invasion by prostate cancer cell lines. Reviewed

    Pitchakarn P, Chewonarin T, Ogawa K, Suzuki S, Asamoto M, Takahashi S, Shirai T, Limtrakul P

    Asian Pacific journal of cancer prevention : APJCP   14 ( 5 )   2859 - 63   2013( ISSN:1513-7368

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  • Effects of co-administration of dietary sodium arsenate and 2,3-dimercaptopropane-1-sulfonic acid (DMPS) on the rat bladder epithelium. Reviewed

    Suzuki S, Arnold LL, Pennington KL, Kakiuchi-Kiyota S, Chen B, Lu X, Le XC, Cohen SM

    Toxicology   299 ( 2-3 )   155 - 9   2012.09( ISSN:0300-483X

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    DOI: 10.1016/j.tox.2012.05.019

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  • 頭蓋骨転移で発症した悪性paragangliomaの1例 Reviewed

    金井 秀樹, 山下 伸子, 橋本 信和, 小川 久美子, 鈴木 周五

    (株)医学書院 Neurological Surgery   40 ( 8 )   711 - 716   2012.08( ISSN:0301-2603

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    症例は61歳男性で、7年前に右腎門部の腫瘍が発見され、腎摘出術で腎細胞癌と診断されていた。左側頭部腫脹と左眼球突出を自覚し、CTで蝶形骨や眼窩外側に骨融解を伴い、側頭部軟部組織へ進展した腫瘍が左中頭蓋窩前方に低吸収域として描出された。腫瘍はMRIのT1WIで辺縁高信号、内部等信号、T2WIで高信号を示し、gadoliniumで辺縁がリング状に増強された。腫瘍摘出術を施行し、病理組織所見で腫瘍中心部は広範な凝固壊死を示し、辺縁に骨や筋肉へ浸潤した腫瘍細胞が認められた。比較的均一な核を有する円形〜類円形の腫瘍細胞が、毛細血管と単層で紡錘形のsustentacular cellとで分葉されて胞巣状に配列し、変性を認めたが核異型、核分裂像、脈管浸潤はなかった。既往の腎門部腫瘍と同様の所見であり、paragangliomaの頭蓋骨転移と診断された。術後症状は改善し化学療法を追加したが、2年2ヵ月後より肩甲骨などに転移を生じ、状態は徐々に悪化して4年1ヵ月後に死亡した。

  • Silencing of connexin 43 suppresses invasion, migration and lung metastasis of rat hepatocellular carcinoma cells. Reviewed

    Ogawa K, Pitchakarn P, Suzuki S, Chewonarin T, Tang M, Takahashi S, Naiki-Ito A, Sato S, Takahashi S, Asamoto M, Shirai T

    Cancer science   103 ( 5 )   860 - 7   2012.05( ISSN:1347-9032

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    DOI: 10.1111/j.1349-7006.2012.02228.x

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  • Late in-stent restenosis after sirolimus-eluting stent implantation is related to thrombus formation-Insight from a case with IVUS, OCT, and histological findings. Reviewed

    Ito S, Nakasuka K, Miyata K, Inomata M, Yoshida T, Tamai N, Suzuki S, Murakami Y, Suzuki S, Sato K

    Journal of cardiology cases   5 ( 2 )   e83 - e86   2012.04

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    DOI: 10.1016/j.jccase.2011.11.004

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  • Kuguacin J, a triterpeniod from Momordica charantia leaf, modulates the progression of androgen-independent human prostate cancer cell line, PC3. Reviewed

    Pitchakarn P, Suzuki S, Ogawa K, Pompimon W, Takahashi S, Asamoto M, Limtrakul P, Shirai T

    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association   50 ( 3-4 )   840 - 7   2012.03( ISSN:0278-6915

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    DOI: 10.1016/j.fct.2012.01.009

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  • Immunohistochemical analysis of uroplakins, urothelial-specific proteins in sinonasal Schneiderian papillomas. Reviewed

    Ogawa K, Mamiya S, Sato S, Naiki-Ito A, Suzuki S, Takahashi S, Cohen SM, Shirai T

    Histopathology   60 ( 2 )   365 - 9   2012.01( ISSN:0309-0167

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    DOI: 10.1111/j.1365-2559.2011.04018.x

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  • Evaluation of direct and indirect effects of the PPARγ agonist troglitazone on mouse endothelial cell proliferation. Reviewed

    Kakiuchi-Kiyota S, Arnold LL, Yokohira M, Koza-Taylor P, Suzuki S, Varney M, Pennington KL, Cohen SM

    Toxicologic pathology   39 ( 7 )   1032 - 45   2011.12( ISSN:0192-6233

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    DOI: 10.1177/0192623311422080

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  • Roles for rat hepatocyte malignant transforming factor (HMTF) in late stage of hepatocarcinogenesis. Reviewed

    Suzuki S, Pitchakarn P, Takeshita K, Asamoto M, Takahashi S, Sato S, Shirai T

    Toxicologic pathology   39 ( 7 )   1084 - 90   2011.12( ISSN:0192-6233

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    DOI: 10.1177/0192623311422077

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  • Evaluation of PPARγ agonists on rodent endothelial cell proliferation. Reviewed

    Kakiuchi-Kiyota S, Arnold LL, Yokohira M, Suzuki S, Pennington KL, Cohen SM

    Toxicology   287 ( 1-3 )   91 - 8   2011.09( ISSN:0300-483X

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    DOI: 10.1016/j.tox.2011.05.019

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  • Induction of G1 arrest and apoptosis in androgen-dependent human prostate cancer by Kuguacin J, a triterpenoid from Momordica charantia leaf. Reviewed

    Pitchakarn P, Suzuki S, Ogawa K, Pompimon W, Takahashi S, Asamoto M, Limtrakul P, Shirai T

    Cancer letters   306 ( 2 )   142 - 50   2011.07( ISSN:0304-3835

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    DOI: 10.1016/j.canlet.2011.02.041

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  • Effect of sodium arsenite dose administered in the drinking water on the urinary bladder epithelium of female arsenic (+3 oxidation state) methyltransferase knockout mice. Reviewed

    Yokohira M, Arnold LL, Pennington KL, Suzuki S, Kakiuchi-Kiyota S, Herbin-Davis K, Thomas DJ, Cohen SM

    Toxicological sciences : an official journal of the Society of Toxicology   121 ( 2 )   257 - 66   2011.06( ISSN:1096-6080

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    DOI: 10.1093/toxsci/kfr051

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  • A case of extended late-phase in-stent restenosis after implantation of a bare-metal stent: intravascular ultrasound, optical coherence tomography and immunohistochemical findings. Reviewed

    Ito S, Yoshida T, Suzuki S

    The Journal of invasive cardiology   23 ( 4 )   E86 - 91   2011.04( ISSN:1042-3931

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  • Effects of nobiletin on PhIP-induced prostate and colon carcinogenesis in F344 rats. Reviewed

    Tang MX, Ogawa K, Asamoto M, Chewonarin T, Suzuki S, Tanaka T, Shirai T

    Nutrition and cancer   63 ( 2 )   227 - 33   2011( ISSN:0163-5581

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    DOI: 10.1080/01635581.2011.523506

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  • Jun activation domain binding protein 1 is overexpressed from the very early stages of hepatocarcinogenesis. Reviewed

    Yachida S, Imaida K, Yokohira M, Hashimoto N, Suzuki S, Okano K, Wakabayashi H, Maeta H, Suzuki Y

    Annals of surgical oncology   17 ( 12 )   3386 - 93   2010.12( ISSN:1068-9265

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    DOI: 10.1245/s10434-010-1197-7

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  • Momordica charantia leaf extract suppresses rat prostate cancer progression in vitro and in vivo. Reviewed

    Pitchakarn P, Ogawa K, Suzuki S, Takahashi S, Asamoto M, Chewonarin T, Limtrakul P, Shirai T

    Cancer science   101 ( 10 )   2234 - 40   2010.10( ISSN:1347-9032

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    DOI: 10.1111/j.1349-7006.2010.01669.x

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  • Severe systemic toxicity and urinary bladder cytotoxicity and regenerative hyperplasia induced by arsenite in arsenic (+3 oxidation state) methyltransferase knockout mice. A preliminary report. Reviewed

    Yokohira M, Arnold LL, Pennington KL, Suzuki S, Kakiuchi-Kiyota S, Herbin-Davis K, Thomas DJ, Cohen SM

    Toxicology and applied pharmacology   246 ( 1-2 )   1 - 7   2010.07( ISSN:0041-008X

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    DOI: 10.1016/j.taap.2010.04.013

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  • 2-Amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx)-induced hepatocarcinogenesis is not enhanced by CYP1A inducers, alpha- and beta-naphthoflavone: relationship to intralobular distribution of CYP1A expression. Reviewed

    Suzuki S, Takeshita K, Doi Y, Asamoto M, Takahashi S, Naiki-Ito A, Shirai T

    Toxicologic pathology   38 ( 4 )   583 - 91   2010.06( ISSN:0192-6233

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    DOI: 10.1177/0192623310367808

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  • Dietary administration of sodium arsenite to rats: relations between dose and urinary concentrations of methylated and thio-metabolites and effects on the rat urinary bladder epithelium. Reviewed

    Suzuki S, Arnold LL, Pennington KL, Chen B, Naranmandura H, Le XC, Cohen SM

    Toxicology and applied pharmacology   244 ( 2 )   99 - 105   2010.04( ISSN:0041-008X

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    DOI: 10.1016/j.taap.2009.12.026

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  • Effects of Pioglitazone, a Peroxisome Proliferator-Activated Receptor Gamma Agonist, on the Urine and Urothelium of the Rat Reviewed

    Suzuki S, Arnold LL, Pennington KL, Kakiuchi-Kiyota S, Wei M, Wanibuchi H, Cohen SM

    Toxicological sciences : an official journal of the Society of Toxicology   113 ( 2 )   349 - 357   2010.02( ISSN:1096-6080

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    DOI: 10.1093/toxsci/kfp256

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  • Effects of co-administration of dietary sodium arsenite and an NADPH oxidase inhibitor on the rat bladder epithelium. Reviewed

    Suzuki S, Arnold LL, Pennington KL, Kakiuchi-Kiyota S, Cohen SM

    Toxicology   261 ( 1-2 )   41 - 6   2009.06( ISSN:0300-483X

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.tox.2009.04.042

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  • Effects of an epidermal growth factor receptor inhibitor on arsenic associated toxicity in the rat bladder epithelium. Reviewed

    Suzuki S, Arnold LL, Pennington KL, Chen B, Le XC, Cohen SM

    Toxicology letters   187 ( 2 )   124 - 9   2009.06( ISSN:0378-4274

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    DOI: 10.1016/j.toxlet.2009.02.013

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  • Effects of the PPARgamma agonist troglitazone on endothelial cells in vivo and in vitro: differences between human and mouse. Reviewed

    Kakiuchi-Kiyota S, Vetro JA, Suzuki S, Varney ML, Han HY, Nascimento M, Pennington KL, Arnold LL, Singh RK, Cohen SM

    Toxicology and applied pharmacology   237 ( 1 )   83 - 90   2009.05( ISSN:0041-008X

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    DOI: 10.1016/j.taap.2009.02.028

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  • High mobility group box associated with cell proliferation appears to play an important role in hepatocellular carcinogenesis in rats and humans. Reviewed

    Suzuki S, Takeshita K, Asamoto M, Takahashi S, Kandori H, Tsujimura K, Saito F, Masuko K, Shirai T

    Toxicology   255 ( 3 )   160 - 70   2009.01( ISSN:0300-483X

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    DOI: 10.1016/j.tox.2008.10.023

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  • Inorganic arsenic-induced intramitochondrial granules in mouse urothelium. Reviewed

    Suzuki S, Arnold LL, Muirhead D, Lu X, Le XC, Bjork JA, Wallace KB, Ohnishi T, Kakiuchi-Kiyota S, Pennington KL, Cohen SM

    Toxicologic pathology   36 ( 7 )   999 - 1005   2008.12( ISSN:0192-6233

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    DOI: 10.1177/0192623308327408

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  • Effects of inorganic arsenic on the rat and mouse urinary bladder. Reviewed

    Suzuki S, Arnold LL, Ohnishi T, Cohen SM

    Toxicological sciences : an official journal of the Society of Toxicology   106 ( 2 )   350 - 63   2008.12( ISSN:1096-6080

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    DOI: 10.1093/toxsci/kfn184

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  • Cytotoxicity of combinations of arsenicals on rat urinary bladder urothelial cells in vitro. Reviewed

    Nascimento MG, Suzuki S, Wei M, Tiwari A, Arnold LL, Lu X, Le XC, Cohen SM

    Toxicology   249 ( 1 )   69 - 74   2008.07( ISSN:0300-483X

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    DOI: 10.1016/j.tox.2008.04.007

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  • Suppressive effects of antiandrogens, finasteride and flutamide on development of prostatic lesions in a transgenic rat model Reviewed

    Y. M. Cho, S. Takahashi, M. Asamoto, S. Suzuki, M. Tang, T. Shirai

    Prostate Cancer and Prostatic Diseases   10   378 - 383   2007.12( ISSN:13657852

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    Transgenic (TG) rats bearing a probasin promoter/simian virus 40 T antigen (SV40 Tag) construct were treated with antiandrogens to examine their ability to suppress prostate carcinogenesis. Finasteride and flutamide were administered to 10-week-old TG rats five times a week for 2, 5 and 7 weeks. Antiandrogen-treated prostates exhibited atrophic glandular structures with almost no expression of SV40 Tag and only weak signals for androgen receptors. Furthermore, quantitative data for ventral prostate adenocarcinomas showed significant decrease with antiandrogen treatment. Both finasteride and flutamide had the ability to suppress SV40 Tag-driven carcinogenesis through their different antiandrogenic mechanisms, suggesting that this TG model is suitable for exploring the potential of agents to inhibit prostate cancer development.

    DOI: 10.1038/sj.pcan.4500971

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  • Protective effects of citrus nobiletin and auraptene in transgenic rats developing adenocarcinoma of the prostate (TRAP) and human prostate carcinoma cells. Reviewed

    Tang M, Ogawa K, Asamoto M, Hokaiwado N, Seeni A, Suzuki S, Takahashi S, Tanaka T, Ichikawa K, Shirai T

    Cancer science   98 ( 4 )   471 - 7   2007.04( ISSN:1347-9032

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    DOI: 10.1111/j.1349-7006.2007.00417.x

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  • Prediction of carcinogenic potential by a toxicogenomic approach using rat hepatoma cells. Reviewed

    Tsujimura K, Asamoto M, Suzuki S, Hokaiwado N, Ogawa K, Shirai T

    Cancer science   97 ( 10 )   1002 - 10   2006.10( ISSN:1347-9032

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    DOI: 10.1111/j.1349-7006.2006.00280.x

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  • Inhibition of prostate carcinogenesis in probasin/SV40 T antigen transgenic rats by leuprorelin, a luteinizing hormone-releasing hormone agonist. Reviewed

    Said MM, Hokaiwado N, Tang M, Ogawa K, Suzuki S, Ghanem HM, Esmat AY, Asamoto M, Refaie FM, Shirai T

    Cancer science   97 ( 6 )   459 - 67   2006.06( ISSN:1347-9032

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    DOI: 10.1111/j.1349-7006.2006.00213.x

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  • Expression of prothymosin alpha is correlated with development and progression in human prostate cancers. Reviewed

    Suzuki S, Takahashi S, Takahashi S, Takeshita K, Hikosaka A, Wakita T, Nishiyama N, Fujita T, Okamura T, Shirai T

    The Prostate   66 ( 5 )   463 - 9   2006.04( ISSN:0270-4137

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    DOI: 10.1002/pros.20385

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  • ラット初代肝細胞を用いた肝発がん物質投与による遺伝子発現変化の解析 Reviewed

    鈴木 周五, 春日 良介, 白井 智之

    名古屋市厚生院 名古屋市厚生院紀要   ( 32 )   11 - 14   2006.04( ISSN:0385-2784

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    ラット肝細胞初代培養法で発現変化を検討した。24時間後、48時間後と対照であるDMSO(final concentration 0.1%)曝露では形態学的に著変ないものの、Aflatoxin B1を曝露した細胞では変性を伴った。検討可能な遺伝子は20128存在し、その遺伝子を対象にMicroarrayの解析方法より、発癌物質と非発癌物質間で発現の異なる遺伝子10066が選出され、4種の発癌物質で遺伝子変動が平均1.5倍以上の71遺伝子が選出された。この71遺伝子を対象に4種の非発癌物質の遺伝子発現の平均と発現差が1.5倍以上あるものは28遺伝子であった。

  • Lack of modification of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) rat hepatocarcinogenesis by caffeine, a CYP1A2 inducer, points to complex counteracting influences. Reviewed

    Kuribayashi M, Asamoto M, Suzuki S, Hokaiwado N, Ogawa K, Shirai T

    Cancer letters   232 ( 2 )   289 - 99   2006.02( ISSN:0304-3835

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    DOI: 10.1016/j.canlet.2005.02.041

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  • Differences between latent and clinical prostate carcinomas: lower cell proliferation activity in latent cases. Reviewed

    Takahashi S, Suzuki S, Takahashi S, Inaguma S, Asamoto M, Shirai T

    The Prostate   66 ( 2 )   211 - 7   2006.02( ISSN:0270-4137

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    DOI: 10.1002/pros.20336

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  • Lack of carcinogenicity of L-isoleucine in F344/DuCrj rats. Reviewed

    Kawabe M, Sano M, Hagiwara A, Tamano S, Suzuki S, Shirai T

    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association   44 ( 2 )   278 - 85   2006.02( ISSN:0278-6915

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    DOI: 10.1016/j.fct.2005.07.011

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  • Lack of prophylactic effect of incadronate on skeletal lesions associated with implants of prostate cancer. Reviewed

    Hikosaka A, Futakuchi M, Ogiso T, Suzuki S, Kohri K, Shirai T

    European urology   49 ( 1 )   176 - 82   2006.01( ISSN:0302-2838

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    DOI: 10.1016/j.eururo.2005.09.021

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  • Pitfalls with MRI evaluation of prostate cancer detection: comparison of findings with histopathological assessment of retropubic radical prostatectomy specimens. Reviewed

    Okamura T, Umemoto Y, Yamashita K, Suzuki S, Shirai T, Hashimoto Y, Kohri K

    Urologia internationalis   77 ( 4 )   301 - 6   2006( ISSN:0042-1138

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    DOI: 10.1159/000096332

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  • 右大腿部軟部腫瘍の1例 Reviewed

    中島 浩敦, 筑紫 聡, 紫藤 洋二, 新井 英介, 鈴木 周五

    東海骨軟部腫瘍研究会 東海骨軟部腫瘍   17   11 - 12   2005.06( ISSN:0915-8383

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    48歳男.Cellular angiofibromaと考えられた右大腿部軟部腫瘍症例であった.約4年前から右大腿部の無痛腫瘤を自覚し,徐々に増大した.初診時は6×6cm大となっており,MRIでは縫工筋内に,MRI T1強調像で筋肉と等信号,T2強調像で不均一な高信号を示す腫瘍を認め,低信号の被膜様構造も認めた.生検を行い,病理学的には小血管の豊富な,myxomatousな間質を持つ腫瘍であった.臨床的には悪性と考え広範切除を行い,術後8ヵ月現在,再発は認められない.腫瘍は黄白色の充実性で,隣接する筋肉への浸潤を示す部分も認められ,組織学的には浮腫状の間質の中に多数の壁の薄い血管腔がみられた.免疫組織化学的にはdesmin陽性,SM actinおよびHHF35は部分的陽性,S-100,CD31,CD34,EMAは陰性であった

  • 転移性骨腫瘍におけるCTガイド下針生検の意義 Reviewed

    筑紫 聡, 中島 浩敦, 鈴木 周五, 片桐 浩久

    (株)南江堂 整形外科   56 ( 5 )   525 - 528   2005.05( ISSN:0030-5901

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    転移性骨腫瘍の疑いの34例にCTガイド下針生検を行った.正診率は100%であり,合併症は認めなかった.腫瘍細胞が同定されたのは22例で,そのうち14例は採取された組織結果により,原発巣やや癌種の診断が可能であった.4例は原発巣や癌種を診断できず,免疫組織化学染色により2例が肺の腺癌と診断された.CTガイド下針生検は適応症例を慎重に選ぶことが必要であり,原発不明癌の原発巣探索には確実な組織採取と免疫組織化学染色による検討が必要であると思われた

  • Linkage and microarray analyses of susceptibility genes in ACI/Seg rats: a model for prostate cancers in the aged. Reviewed

    Yamashita S, Suzuki S, Nomoto T, Kondo Y, Wakazono K, Tsujino Y, Sugimura T, Shirai T, Homma Y, Ushijima T

    Cancer research   65 ( 7 )   2610 - 6   2005.04( ISSN:0008-5472

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    DOI: 10.1158/0008-5472.CAN-04-2932

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  • Influence of atrazine administration and reduction of calorie intake on prostate carcinogenesis in probasin/SV40 T antigen transgenic rats. Reviewed

    Kandori H, Suzuki S, Asamoto M, Murasaki T, Mingxi T, Ogawa K, Shirai T

    Cancer science   96 ( 4 )   221 - 6   2005.04( ISSN:1347-9032

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    DOI: 10.1111/j.1349-7006.2005.00041.x

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  • Downregulation of apoptosis revealed by laser microdissection and cDNA microarray analysis of related genes in rat liver preneoplastic lesions. Reviewed

    Ogawa K, Asamoto M, Suzuki S, Tsujimura K, Shirai T

    Medical molecular morphology   38 ( 1 )   23 - 9   2005.03( ISSN:1860-1480

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    DOI: 10.1007/s00795-004-0265-0

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  • 大腿部に発生したcellular angiofibromaの1例 Reviewed

    中島 浩敦, 紫藤 洋二, 新井 英介, 浦川 浩, 筑紫 聡, 鈴木 周五

    (株)南江堂 整形外科   56 ( 2 )   196 - 197   2005.02( ISSN:0030-5901

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    48歳男.右大腿部腫瘤を主訴とした.右大腿部の無痛性腫瘤が約4年の経過で増大傾向を示し,MRIのT1強調画像で低信号,T2強調画像で不均一な高信号を呈した.広範切除施行後は無再発で経過している.病理組織学的に浮腫状の間質の中にみられる多数の壁の薄い血管腔が特徴的であり,紡錘形細胞の密度は不均一で厚い束状の膠原線維も認めた.免疫組織化学的検索ではdesmin陽性,SM,actinとHHF35に一部陽性,S-100,CD31,CD34,EMA陰性でmyofibroblasticな分化を示すものであり,大腿部に発生したangiofibromaと診断した.WHOの分類ではcellular angiofibromaに属するものと考えられ,希少な症例として報告した

  • Kinetics of marked development of lung metastasis of rat prostatic carcinomas transplanted in syngeneic rats. Reviewed

    Zhao L, Futakuchi M, Suzuki S, Ohhara Y, Hashimoto T, Suzuki T, Manabe T, Shirai T

    Clinical & experimental metastasis   22 ( 4 )   309 - 18   2005( ISSN:0262-0898

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    DOI: 10.1007/s10585-005-0054-8

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  • Lack of effects of gestational and lactational exposure to 4-Nonylphenol on PhIP-induced rat prostate carcinogenesis Reviewed

    Yoshino H, Nabae K, Doi Y, Ichihara T, Tamano S, Suzuki S, Shirai T

    Journal of Toxicologic Pathology   18   183 - 188   2005

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    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

  • p-Nonylphenol pretreatment during the late neonatal period has no effect on 3,2'-dimethyl-4-aminobiphenyl-induced prostate carcinogenesis in male F344 rats Reviewed

    Inaguma S, Takahashi S, Imaida K, Suzuki S, Shirai T

    Cancer Lett   212 ( 2 )   159 - 166   2004

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    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

  • Expression of myelencephalon-specific protease in transient middle cerebral artery occlusion model of rat brain Reviewed

    Uchida A, Oka Y, Aoyama M, Suzuki S, Yokoi T, Katano H, Mase M, Tada T, Asai K, Yamada K

    Brain Res Mol Brain Res   126 ( 2 )   129 - 136   2004

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    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

  • Renal toxicity induced by folic acid is associated with the enhancement of male reproductive toxicity of di(n-butyl)phthalate in rats Reviewed

    Tsutsumi T, Ichihara T, Kawabe M, Yoshino H, Asamoto M, Suzuki S, Shirai T

    Reprod Toxicol   18 ( 1 )   35 - 42   2004

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    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

  • Specific differences in gene expression profile revealed by cDNA microarray analysis of glutathione S-transferase placental form (GST-P) immunohistochemically positive rat liver foci and surrounding tissue Reviewed

    Suzuki S, Asamoto M, Tsujimura K, Shirai T

    Carcinogenesis   25 ( 3 )   439 - 443   2004

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    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

  • Reactive angioendotheliomatosis of the intestine Reviewed

    Ogawa K, Tada T, Takeuchi Y, Suenaga M, Suzuki S, Shirai T

    Am J Surg Pathol   28 ( 2 )   257 - 261   2004

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    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

  • Age-dependent histopathological findings in the prostate of probasin/SV40 T antigen transgenic rats: lack of influence of carcinogen or testosterone treatment Reviewed

    Cho YM, Takahashi S, Asamoto M, Suzuki S, Inaguma S, Hokaiwado N, Shirai T

    Cancer Sci   94 ( 2 )   153 - 157   2003

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    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

  • Down-regulated expression of prostasin in high-grade or hormone-refractory human prostate cancers Reviewed

    Takahashi S, Suzuki S, Inaguma S, Ikeda Y, Cho YM, Hayashi N, Inoue T, Sugimura Y, Nishiyama N, Fujita T, Chao J, Ushijima T, Shirai T

    Prostate   54 ( 3 )   187 - 193   2003

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    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

  • High susceptibility of the ACI and spontaneously hypertensive rat (SHR) strains to 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) prostate carcinogenesis Reviewed

    Inaguma S, Takahashi S, Ohnishi H, Suzuki S, Cho YM, Shirai T

    Cancer Sci   94 ( 11 )   974 - 979   2003

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    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

  • Lack of carcinogenic risk in the prostate with transplacental and lactational exposure to bisphenol A in rats Reviewed

    Ichihara T, Yoshino H, Imai N, Tsutsumi T, Kawabe M, Tamano S, Inaguma S, Suzuki S, Shirai T

    J Toxicol Sci   28 ( 3 )   165 - 171   2003

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    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

  • Organ differences in the enhancing potential of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine on carcinogenicity in the prostate, colon and pancreas Reviewed

    Shirai T, Kato K, Futakuchi M, Takahashi S, Suzuki S, Imaida K, Asamoto M.

    Mutat Res   506-507   129 - 136   2002

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    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

  • Down-regulation of human X-box binding protein 1 (hXBP-1) expression correlates with tumor progression in human prostate cancers Reviewed

    Takahashi S, Suzuki S, Inaguma S, Ikeda Y, Cho YM, Nishiyama N, Fujita T, Inoue T, Hioki T, Sugimura Y, Ushijima T, Shirai T

    Prostate   50 ( 3 )   154 - 161   2002

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    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

  • Down-regulation of Lsm1 is involved in human prostate cancer progression Reviewed

    Takahashi S, Suzuki S, Inaguma S, Cho YM, Ikeda Y, Hayashi N, Inoue T, Sugimura Y, Nishiyama N, Fujita T, Ushijima T, Shirai T

    Br J Cancer   86 ( 6 )   940 - 946   2002

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    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

  • DNA methylation in the androgen receptor gene promoter region in rat prostate cancers Reviewed

    Takahashi S, Inaguma S, Sakakibara M, Cho YM, Suzuki S, Ikeda Y, Cui L, Shirai T

    Prostate   52 ( 1 )   82 - 88   2002

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    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

  • Lack of modification of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx)-induced hepatocarcinogenesis in rats by fenbendazole--a CYP1A2 inducer Reviewed

    Suzuki S, Takahashi S, Asamoto M, Inaguma S, Ogiso T, Hirose M, Shirai T

    Cancer Lett   185 ( 1 )   39 - 45   2002

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    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

  • Suppressive effects of dietary genistin and daidzin on rat prostate carcinogenesis Reviewed

    Kato K, Takahashi S, Cui L, Toda T, Suzuki S, Futakuchi M, Sugiura S, Shirai, T.

    Jpn J Cancer Res   91 ( 8 )   786 - 791   2000

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    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

  • Enhancing effects of 2-amino-4,5-diphenylthiazole-induced polycystic kidneys on renal carcinogenesis in rats treated with dimethylnitrosamine Reviewed

    Takahashi S, Ikeda Y, Orita S, Sakakibara M, Kimoto N, Suzuki S, Imaida K, Shirai T.

    Toxicol Appl Pharmacol   167 ( 1 )   12 - 17   2000

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    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

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Books and Other Publications

  • Gamma-H2AX Expression as a Biomarker of Carcinogenesis: Applications to Toxicology

    Shugo Suzuki, Hideki Wanibuchi( Role: Joint author)

    Biomarkers in Toxicology. Biomarkers in Disease: Methods, Discoveries and Applications. Springer, Cham.  2022.03  ( ISBN:978-3-030-87225-0

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    Total pages:1090   Responsible for pages:1-15   Book type:Scholarly book Participation form:First Author

    DOI: https://doi.org/10.1007/978-3-030-87225-0_8-1

  • Kuguacin J, a Triterpenoid from Momordica charantia Linn: A Comprehensive Review of Anticarcinogenic Properties International journal

    Pornngarm Limtrakul, Pornsiri Pitchakarn and Shugo Suzuki( Role: Joint author)

    Carcinogenesis. InTech  2013.01 

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    Total pages:330   Responsible for pages:275-296   Book type:Scholarly book

    DOI: doi:10.5772/55532

  • Urinary Tract Calculi and Bladder Tumors International journal

    Samuel M. Cohen, Lora L. Arnold, Shugo Suzuki( Role: Contributor)

    Cancer Risk Assessment: Chemical Carcinogenesis, Hazard Evaluation, and Risk Quantification  2010.08 

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    Total pages:824   Responsible for pages:501-514   Book type:Scholarly book Participation form:Last Author

    Scopus

MISC

  • Occupational exposure to aromatic amines and urinary bladder cancers Invited International journal

    Precision Medicine   6 ( 4 )   25 - 29   2023.04( ISSN:2434-3625

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    Authorship:Lead author   International / domestic magazine:Domestic journal  

  • 【環境因子と発がん】化学物質曝露による職業がんの発生要因とメカニズム 動物実験を基礎とした新たな職業性膀胱がん原因物質の発見 Invited

    鰐渕 英機, 魏 民, 鈴木 周五

    (株)羊土社 実験医学   38 ( 11 )   1842 - 1848   2020.07( ISSN:0288-5514

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    Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

    職業に起因する発がん要因に曝露され生じるがんを職業がんといい、産業の発達とともに大きな問題となっている。職業性膀胱がんは主に染料産業に発生し、芳香族アミンが主な原因物質として報告されている。日本でも2019年にオルトトルイジンにさらされる業務による膀胱がんが、厚生労働省の「職業病リスト」に記載され、労災補償の対象となり話題となった。われわれは同工場で生産されていた新規芳香族アミンの発がん性およびそのメカニズムを、動物実験を介して解明した。ここでは、職業がんの歴史から発がん物質の検出法、動物実験モデルの有効性について解説したい。(著者抄録)

  • 【"ヒ素"とは何か】発がん物質としてのヒ素 Invited

    鈴木 周五, 魏 民, 鰐渕 英機

    (株)杏林書院 保健の科学   62 ( 6 )   374 - 379   2020.06( ISSN:0018-3342

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  • 【泌尿器の慢性炎症】 前立腺発癌と炎症 Invited

    鈴木 周五, 内木 綾, 加藤 寛之, 早川 将史, 高橋 智

    (株)北隆館 別冊Bio Clinica: 慢性炎症と疾患   5 ( 4 )   84 - 88   2016.11

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    Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

    前立腺癌発生には種々の原因が知られているが、慢性炎症もその1つと考えられている。前立腺検体における慢性炎症からみた疫学的研究では前立腺炎と癌発生との関連について一定の見解は得られていないが、実験的レベルではその相関性が明らかにされている。前立腺癌は急増する癌であり、前立腺癌予防法の確立は重要課題である。前立腺における炎症関連発癌研究の進展によりそのメカニズムが詳細に解明され、炎症を標的とした前立腺癌予防法が確立されることが期待される。(著者抄録)

  • ギャップ結合性細胞間連絡能異常がきたす肝発がんのメカニズム Invited

    内木 綾, 加藤 寛之, 佐藤 慎哉, 鈴木 周五, 山下 依子, 久野 壽也, 高橋 智

    (公社)愛知県医師会 現代医学   64 ( 1 )   103 - 108   2016.06( ISSN:0433-3047

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    Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

    ギャップ結合は細胞間結合装置の一種で、隣接細胞間の小分子交換を介して組織や生体のホメオスタシスを担っている。当研究室では、肝細胞のギャップ結合タンパクであるCx32(connexin 32)がドミナントネガティブに抑制され、細胞間連絡能が著減したトランスジェニックラットを樹立し、肝障害や肝発癌に対するギャップ結合性細胞間コミュニケーションの役割を解析してきた。本稿では、アルコール性肝発癌および非アルコール性脂肪肝炎に関連した発癌感受性に対する細胞間コミュニケーションの影響と、それぞれの発癌に関与する遺伝子を同定した最近の知見を報告する。(著者抄録)

  • 【最新肝癌学-基礎と臨床の最新研究動向-】 肝癌の危険因子と発癌機序 非B非C肝癌 非B非C肝癌の危険因子と発癌機序 その他の化学物質発がん(アフラトキシン、ニトロソ化合物など) Invited

    佐藤 慎哉, 内木 綾, 鈴木 周五, 高橋 智

    (株)日本臨床社 日本臨床   73 ( 増刊1 最新肝癌学 )   142 - 146   2015.01( ISSN:0047-1852

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    Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 前立腺癌に対するHDAC阻害剤の予防および治療効果の検討 Invited

    佐藤 慎哉, 鈴木 周五, 内木 綾, 白井 智之, 高橋 智

    医学図書出版(株) 泌尿器外科   27 ( 8 )   1217 - 1219   2014.08( ISSN:0914-6180

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    Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

    ヒストンアセチル化を促進するHistone deacetylase(HDAC)阻害剤は前立腺癌を含む様々な癌腫に対する抗癌作用を有し、増殖抑制メカニズムの特異性から前立腺癌に対する新規抗癌剤として期待されている。一方、前立腺癌は発症までの期間が長いことから予防的介入が可能な癌として注目されており、HDAC阻害剤は前立腺癌の予防物質としても期待される。本章では臨床応用を考え開発が進んでいる、副作用の少ない選択的HDAC阻害剤の癌治療効果、予防効果を報告する。(著者抄録)

  • 多様な環境下での前立腺癌の増殖におけるヒストンアセチル化の関与 Invited

    佐藤 慎哉, 鈴木 周五, 内木 綾, 朝元 誠人, 高橋 智

    医学図書出版(株) 泌尿器外科   25 ( 8 )   1609 - 1611   2012.08( ISSN:0914-6180

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    Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

    前立腺癌は環境に応じた多様な増殖機構を有することから、前立腺癌の治療には多様な増殖機構を幅広く抑制する治療法の開発が必要である。ヒストンアセチル化は遺伝子のエピジェネティックな発現制御機構の1つであり、ヒストンアセチル化を促進するHistone deacetylase(HDAC)阻害剤は癌細胞に対する増殖抑制作用を有し、前立腺癌に対する新規抗癌剤の候補になり得る可能性がある。本章ではヒストンアセチル化とHDAC阻害剤の概要、およびHDAC阻害剤の前立腺癌に対する増殖抑制メカニズムを中心に報告する。(著者抄録)

  • 【腎臓症候群(第2版)上-その他の腎臓疾患を含めて-】 腫瘍性腎疾患 腎腺腫 Invited

    鈴木 周五, 高橋 智

    (株)日本臨床社 日本臨床   別冊 ( 腎臓症候群(上) )   654 - 656   2012.01( ISSN:0047-1852

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    Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 厚生院における病理解剖(XXVI) Reviewed

    鈴木 周五, 佐藤 慎哉, 関 健司

    名古屋市厚生院 名古屋市厚生院紀要   ( 33 )   73 - 74   2007.04( ISSN:0385-2784

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    Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 厚生院における病理解剖(XXV) Reviewed

    高橋 青志郎, 鈴木 周五, 関 健司

    名古屋市厚生院 名古屋市厚生院紀要   ( 32 )   49 - 50   2006.04( ISSN:0385-2784

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Presentations

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Grant-in-Aid for Scientific Research

  • Mechanisms of Hepatocarcinogenesis via Epigenetics Induced by Transplacental Exposure to Dimethylarsinic Acid

    Grant-in-Aid for Scientific Research(C)  2024

  • ジメチルアルシン酸経胎盤ばく露によるエピジェネティクスを介した肝発がん機序の解明

    Grant-in-Aid for Scientific Research(C)  2023.04

  • ジメチルアルシン酸経胎盤ばく露によるエピジェネティクスを介した肝発がん機序の解明

    Grant-in-Aid for Scientific Research(C)  2022.04

  • The role of HMGB2 on prostate cancer progression and castration resistance

    Grant-in-Aid for Scientific Research(C)  2015.04

  • The role of gap junctional intercellular communication in NASH and its-related hepatocarcinogenesis

    Grant-in-Aid for Scientific Research(C)  2014.04

  • Development of a novel photodynamic therapy with sugar-conjugated chlorin targeting tumor-associated macrophages in cancer stroma.

    Grant-in-Aid for Scientific Research(C)  2014.04

  • Functional analysis of MID1 that may be a candidate as a therapeutic target for castration-resistant prostate cancer

    Grant-in-Aid for Scientific Research(C)  2012.04

  • Development of novel PDT with glucose-conjugated chlorin for gastric cancer and GIST

    Grant-in-Aid for Scientific Research(C)  2011

  • The significance of ES cell expressed Ras, ERas as a novel target for gastric cancer treatment

    Grant-in-Aid for Scientific Research(C)  2010

  • Development of a in vivo screening method for evaluation prostate carcinogenic potential in chemicals

    Grant-in-Aid for Scientific Research(C)  2006

  • ラット肝発がんに関わる新規がん遺伝子の同定と機能解析

    Grant-in-Aid for Young Scientists(B)  2006

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Incentive donations / subsidies

  • 化審法における監視化学物質・優先評価化学物質の長期毒性評価スキームの創出に関する研究

    厚生労働省  2022.04

  • 芳香族アミン代謝に着目した膀胱発がん評価法の開発

    厚生労働省  2022.04

  • 化審法における監視化学物質・優先評価化学物質の長期毒性評価スキームの創出に関する研究

    厚生労働省  2021.04

  • 芳香族アミン代謝に着目した膀胱発がん評価法の開発

    厚生労働省  2021.04

  • 化審法における監視化学物質・優先評価化学物質の長期毒性評価スキームの創出に関する研究

    厚生労働省  2020.04

  • 芳香族アミン代謝に着目した膀胱発がん評価法の開発

    厚生労働省  2020.04

  • 化学物質の有害性評価の迅速化・高度化・標準化に関する研究

    厚生労働省  2017.04

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Outline of education staff

  • 病理学とは「病(やまい)」の「理(ことわり)」を「学(まな)」ぶものであり、疾患の成り立ちの解明を目的とする学問領域である。
    また、病理学は基礎医学と臨床医学の懸け橋であり、病気が発生する基本的な機序を理解し、病因に基づいた疾病の分類を把握して頂きたい。

Charge of on-campus class subject

  • Molecular Pathology(Clinico-pathological conference)

    2024     Graduate school

  • Molecular Pathology(Experimental Pathology)

    2024     Graduate school

  • Molecular Pathology(Experimental oncology)

    2024     Graduate school

  • Basic Course of Urban Medicine

    2024     Graduate school

  • Urban Medicine

    2024     Graduate school

  • 医学研究概論

    2023   Weekly class   Graduate school

  • Pathologic Basis of Disease

    2023     Undergraduate

  • 人体を考える

    2022   Weekly class   Undergraduate

  • 臨床病態学2

    2022   Weekly class   Graduate school

  • 医学研究概論

    2022   Weekly class   Graduate school

  • Pathologic Basis of Disease

    2022     Undergraduate

  • Pathologic Basis of Disease

    2021     Undergraduate

  • 医学研究概論

    2021   Weekly class   Graduate school

  • Pathologic Basis of Disease

    2020     Undergraduate

  • 臨床病態学Ⅱ

    2020   Weekly class   Graduate school

  • Pathologic Basis of Disease

    2019     Undergraduate

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Charge of off-campus class subject

  • 基礎腫瘍病理学研究概論

    2023.04
    -
    Now
    Institution:Kumamoto University

  • Pathology

    2021.04
    -
    Now
    Institution:Yamagata University

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    Level:Undergraduate (specialized)  Country:Japan

  • Toxicologic pathology

    2021.04
    -
    Now
    Institution:Nagoya City University

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    Level:Postgraduate  Country:Japan