Updated on 2024/04/10

写真a

 
NAKAYAMA Atsushi
 
Organization
Graduate School of Science Department of Chemistry Lecturer
School of Science Department of Chemistry
Title
Lecturer
Affiliation
Institute of Science
Homepage
http://www.sci.osaka-cu.ac.jp/chem/henkan/

Position

  • Graduate School of Science Department of Chemistry 

    Lecturer  2022.04 - Now

  • School of Science Department of Chemistry 

    Lecturer  2022.04 - Now

Degree

  • 博士（薬学） （ Chiba University ）

Research Areas

  • Others / Others  / Pharmaceuticals - chemistry and drug development - natural product chemistry - chemicalbiology

Research Interests

  • natural Product Chemistry

  • Synthetic Organic Chemistry

  • Medicinal Chemistry

  • Chemical Biology

  • synthetic organic chemistry

  • biosynthesis

  • chemical biology

  • medicinal chemistry

  • natural product chemistry

Research subject summary

  • 自然が生み出した天然有機化合物（天然物）の持つ美しい構造、顕著な生物活性、特異な物性に興味を持ち、天然物そのものだけでなく、それを超えるような新たな擬天然物を創造する研究を行っています。有機合成と生合成を融合した新たな研究も展開しています。

Professional Memberships

  • 日本化学会

      Domestic

  • THE PHARMACEUTICAL SOCIETY OF JAPAN

      Domestic

  • THE SOCIETY OF SYNTHETIC ORGANIC CHEMISTRY, JAPAN

      Domestic

  • 日本ケミカルバイオロジー学会

      Domestic

  • THE SESSILE ORGANISMS SOCIETY OF JAPAN

      Domestic

  • 日本農芸化学会

  • 日本化学会

  • 日本ケミカルバイオロジー学会

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Committee Memberships (off-campus)

  • ファルマシアトピックス小委員   日本薬学会  

    2017.04 - 2019.03 

Awards

  • 2023年度大阪公立大学若手研究者奨励賞

    2023.07   大阪公立大学  

  • The Pharmaceutical Society of Japan Award for Young Scientists

    Atsushi Nakayama

    2022.03   The Pharmaceutical Society of Japan  

  • 令和二年度 日本薬学会生薬天然物部会奨励賞

    2020.07  

  • Young Investigator Award of The Pharmaceutical Society of Japan Division of Natural Medicine

    Atsushi Nakayama

    2020.07   The Pharmaceutical Society of Japan Division of Natural Medicines  

  • 令和元年 天然物化学談話会奨励賞

    2019.09  

  • Young Scientist's Research Award in Natural Product Chemistry

    Atsushi Nakayama

    2019.09  

  • 平成30年度徳島大学若手研究者学長表彰

    2018.12  

  • Young Investigator Award in Tokushima University

    Atsushi Nakayama

    2018.12   Tokushima University  

  • 日本薬学会第130年会学生優秀発表賞

    2012.04  

  • 学生優秀発表賞

    中山 淳

    2012.04   日本薬学会  

  • 公益財団法人上原祈念生命科学財団平成23年度海外助成金ポストドクトラルフェローシップ

    2012.03  

  • Postdoctral Fellowship in 2012

    Atsushi Nakayama

    2012.03   The Uehara Memorial Foundation  

  • 公益財団法人サントリー生命科学財団 平成23年度 SUNBOR SCHOLARSHIP

    2011.03  

  • SUNBOR SCHOLARSHIP in 2011

    Atsushi Nakayama

    2011.03  

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Job Career (off-campus)

  • Graduate School of Science, Osaka Metropolitan University

    2022.04 - Now

  • Osaka City University   Graduate School of Science

    2020.10 - 2022.03

  • Tokushima University   Graduate School of Pharmaceutical Sciences   assistant professor

    2014.06 - 2020.09

  • The Scripps Research Institute   POstdoctral Researcher

    2012.05 - 2014.05

  • Chiba University   Graduate School of Pharmaceutical Sciences

    2009.04 - 2012.03

  • Chiba University   Graduate School of Pharmaceutical Sciences

    2007.04 - 2009.03

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Education

  • Chiba University     Unfinished Course

    2003.04 - 2007.03

Papers

  • First Total Syntheses of Beauvericin A and <i>allo</i>-Beauvericin A Reviewed

    Natsumi Kozakai, Seiya Endo, Atsushi Nakayama, Riku Horinouchi, Makoto Yoshida, Masayoshi Arai, Tetsuro Shinada

    ACS Omega   9 ( 10 )   12228 - 12236   2024.02（ ISSN:2470-1343 ）

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    Publishing type：Research paper (scientific journal)   International / domestic magazine：International journal  

    DOI： 10.1021/acsomega.4c00278

  • Substrate-Dependent Alteration in the C- and O-Prenylation Specificities of Cannabis Prenyltransferase Reviewed

    Ryosuke Tanaya, Takeshi Kodama, Juthamart Maneenet, Yoko Yasuno, Atsushi Nakayama, Tetsuro Shinada, Hironobu Takahashi, Takuya Ito, Hiroyuki Morita, Suresh Awale, Futoshi Taura

    Biological and Pharmaceutical Bulletin   47 ( 2 )   449 - 453   2024.02（ ISSN:0918-6158 ）

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    Publishing type：Research paper (scientific journal)   International / domestic magazine：International journal  

    <p>CsPT4 is an aromatic prenyltransferase that synthesizes cannabigerolic acid (CBGA), the key intermediate of cannabinoid biosynthesis in <i>Cannabis sativa</i>, from olivetolic acid (OA) and geranyl diphosphate (GPP). CsPT4 has a catalytic potential to produce a variety of CBGA analogs <i>via</i> regioselective <i>C</i>-prenylation of aromatic substrates having resorcylic acid skeletons including bibenzyl 2,4-dihydroxy-6-phenylethylbenzoic acid (DPA). In this study, we further investigated the substrate specificity of CsPT4 using phlorocaprophenone (PCP) and 2′,4′,6′-trihydroxydihydrochalcone (THDC), the isomers of OA and DPA, respectively, and demonstrated that CsPT4 catalyzed both <i>C</i>-prenylation and <i>O</i>-prenylation reactions on PCP and THDC that share acylphloroglucinol substructures. Interestingly, the kinetic parameters of CsPT4 for these substrates differed depending on whether they underwent <i>C</i>-prenylation or <i>O</i>-prenylation, suggesting that this enzyme utilized different substrate-binding modes suitable for the respective reactions. Aromatic prenyltransferases that catalyze <i>O</i>-prenylation are rare in the plant kingdom, and CsPT4 was notable for altering the reaction specificity between <i>C</i>- and <i>O</i>-prenylations depending on the skeletons of aromatic substrates. We also demonstrated that enzymatically synthesized geranylated acylphloroglucinols had potent antiausterity activity against PANC-1 human pancreatic cancer cells, with 4′-<i>O</i>-geranyl THDC being the most effective. We suggest that CsPT4 is a valuable catalyst to generate biologically active <i>C</i>- and <i>O</i>-prenylated molecules that could be anticancer lead compounds.</p>

    DOI： 10.1248/bpb.b23-00868

    PubMed

  • Therapeutic efficacy of the resorcylic acid lactone LL‐Z1640‐2 for adult T‐cell leukaemia/lymphoma Reviewed

    Masahiro Oura, Takeshi Harada, Asuka Oda, Jumpei Teramachi, Atsushi Nakayama, Ryohei Sumitani, Yusuke Inoue, Yusaku Maeda, Kimiko Sogabe, Tomoko Maruhashi, Mamiko Takahashi, Shiro Fujii, Shingen Nakamura, Hirokazu Miki, Masafumi Nakamura, Tomoyo Hara, Hiroki Yamagami, Kiyoe Kurahashi, Itsuro Endo, Hiroo Hasegawa, Hiroshi Fujiwara, Masahiro Abe

    eJHaem   4 ( 3 )   667 - 678   2023.07

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    Publishing type：Research paper (scientific journal)   International / domestic magazine：International journal  

    Adult T-cell leukaemia/lymphoma (ATL) remains incurable. The NF-κB and interferon regulatory factor 4 (IRF4) signalling pathways are among the critical survival pathways for the progression of ATL. TGF-β-activated kinase 1 (TAK1), an IκB kinase-activating kinase, triggers the activation of NF-κB. The resorcylic acid lactone LL-Z1640-2 is a potent irreversible inhibitor of TAK1/extracellular signal-regulated kinase 2 (ERK2). We herein examined the therapeutic efficacy of LL-Z1640-2 against ATL. LL-Z1640-2 effectively suppressed the in vivo growth of ATL cells. It induced in vitro apoptosis and inhibited the nuclear translocation of p65/RelA in ATL cells. The knockdown of IRF4 strongly induced ATL cell death while downregulating MYC. LL-Z1640-2 as well as the NF-κB inhibitor BAY11-7082 decreased the expression of IRF4 and MYC at the protein and mRNA levels, indicating the suppression of the NF-κB-IRF4-MYC axis. The treatment with LL-Z1640-2 also mitigated the phosphorylation of p38 MAPK along with the expression of CC chemokine receptor 4. Furthermore, the inhibition of STAT3/5 potentiated the cytotoxic activity of LL-Z1640-2 against IL-2-responsive ATL cells in the presence of IL-2. Therefore, LL-Z1640-2 appears to be an effective treatment for ATL. Further studies are needed to develop more potent compounds that retain the active motifs of LL-Z1640-2.

    DOI： 10.1002/jha2.758

    PubMed

  • Concise Synthesis of Isocoumarin-3-carboxylic Acid Esters Reviewed

    Atsushi Nakayama, Kenichiro Hamamoto†, Ibuki Fujiwara†, Eigo Fukuda, Keita Ozawa, Seiya Endo, Rika Yamasaki, Hidemitsu Yamanaka, Yusaku Tamura, Yuki Yamamoto, Tetsuro Shinada

    Chemistry Letters   52 ( 8 )   640 - 643   2023.06（ ISSN:03667022 ）

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    Authorship：Lead author,　Corresponding author   Publishing type：Research paper (scientific journal)   International / domestic magazine：International journal  

    DOI： 10.1246/cl.230219

  • Synthesis of Drimane-8α,11-diol Using Terpene Cyclase from <i>Bacillus megaterium</i> Reviewed

    Keita Ozawa, Yuki Yamamoto, Eigo Fukuda, Seiya Endo, Atsushi Nakayama, Yoko Yasuno, Daijiro Ueda, Tsutomu Sato, Tetsuro Shinada

    Chemistry Letters   52 ( 6 )   520 - 523   2023.05（ ISSN:0366-7022 ）

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    Publishing type：Research paper (scientific journal)   International / domestic magazine：International journal  

    DOI： 10.1246/cl.230151

  • A suitable stereoisomer of vibrioferrin probes for iron uptake of <i>Vibrio parahaemolyticus</i> Reviewed

    Ryuichi Sumida, Misa Okuda, Akane Mera, Masaki Inoue, Karanjit Sangita, Kanji Niwa, Tomohiro Tsutsumi, Ryota Sato, Atsushi Nakayama, Naonobu Tanaka, Masataka Oda, Kosuke Namba

    Chemistry Letters   52 ( 6 )   477 - 480   2023.05（ ISSN:0366-7022 ）

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    Publishing type：Research paper (scientific journal)   International / domestic magazine：International journal  

    DOI： 10.1246/cl.230166

  • 1,3a,6a-Triazapentalene derivatives as photo-induced cytotoxic small fluorescent dyes Reviewed

    Daisuke Tsuji, Atsushi Nakayama, Riko Yamamoto, Shuji Nagano, Takashi Taniguchi, Ryota Sato, Sangita Karanjit, Naoki Muguruma, Tetsuji Takayama, Kohji Itoh, Kosuke Namba

    Communications Chemistry   6 ( 1 )   2023.02

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    Publishing type：Research paper (scientific journal)   International / domestic magazine：International journal  

    Abstract

    1,3a,6a-Triazapentalene (TAP) is a compact fluorescent chromophore whose fluorescence properties vary greatly depending on the substituents on the TAP ring. This study investigated the photo-induced cytotoxicities of various TAP derivatives. Among the derivatives, 2-p-nitrophenyl-TAP showed significant cytotoxicity to HeLa cells under UV irradiation but no cytotoxicity without UV. In addition, the photo-induced cytotoxicity of 2-p-nitirophenyl-TAP was found to be cancer cell selective and effective against HeLa cells and HCT 116 cells. Under UV irradiation, 2-p-nitrophenyl-TAP generated reactive oxygen species (ROS) that induced an apoptosis and ferroptosis in cancer cells. Therefore, it was revealed that 2-p-nitrophenyl-TAP is the most compact dye that can generate ROS by photoirradiation.

    DOI： 10.1038/s42004-023-00838-0

    Other URL： https://www.nature.com/articles/s42004-023-00838-0

  • Recent Progress in the Synthesis of Deuterated Aldehyde Reviewed

    Tetsuro Shinada, Atsushi Nakayama, Hironori Okamura, Yoko Yasuno

    Bulletin of the Chemical Society of Japan   95 ( 10 )   1461 - 1473   2022.10（ ISSN:0009-2673 ）

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    Publishing type：Research paper (scientific journal)   International / domestic magazine：International journal  

    <p>Deuterium-labeled organic compounds have become indispensable research tools in scientific research. This review focuses on the synthesis of deuterated aldehydes (RCDO) in which the hydrogen at the formyl group is replaced with deuterium. Aldehydes are useful starting materials for organic synthesis. A variety of transformations and derivatizations involving carbon–carbon bond-forming reactions and heteroatom manipulations are possible at the formyl group. Consequently, RCDOs are expected to be a powerful starting material for the synthesis of deuterium-labeled compounds. Many efforts have been devoted to the synthesis of RCDO. The classical and advanced methods are described in this review.</p>

    DOI： 10.1246/bcsj.20220202

  • Formylation Reaction of Amines Using N-Formylcarbazole Reviewed

    Bubwoong Kang, Yuki Shimizu, Yusaku Tamura, Eigo Fukuda, Ken-ichiro Hamamoto, Yuichiro Uchida, Yoko Yasuno, Atsushi Nakayama, Tetsuya Satoh, Masaki Kuse, Tetsuro Shinada

    Chemical & Pharmaceutical Bulletin   70 ( 7 )   492 - 497   2022.05（ ISSN:00092363 ）

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    Publishing type：Research paper (scientific journal)   International / domestic magazine：International journal  

    Formamides are useful starting materials for pharmaceutical syntheses. Although various synthetic methods have been documented in this regard, the use of N-formylcarbazole as a formylation reagent for amines has not yet been reported. We report here the first examples of the use of N-formylcarbazole for the formylation of amines. The characteristic reactivity of N-formylcarbazole enables the selective formylation of sterically less hindered aliphatic primary and secondary amines. In contrast, sterically bulkier amines and weakly nucleophilic amines such as anilines are less reactive under the reaction conditions.

    DOI： 10.1248/cpb.c22-00161

    PubMed

  • Total Syntheses of Proposed Structures of 4,10-Dihydroxy-8,12-guaianolides Reviewed

    Yuki Kimura, Eisaku Ohashi, Sangita Karanjit, Takashi Taniguchi, Atsushi Nakayama, Hiroshi Imagawa, Ryota Sato, Kosuke Namba

    Organic Letters   24 ( 17 )   3297 - 3301   2022.04（ ISSN:1523-7060 ）

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.1021/acs.orglett.2c01215

  • Stereoselective Syntheses of <i>trans</i>-Anhydromevalonic Acid and <i>trans</i>-Anhydromevalonyl Group-Containing Natural Products Reviewed

    Atsushi Nakayama, Yoko Yasuno, Yuki Yamamoto, Kai Saito, Kohei Kitsuwa, Hironori Okamura, Tetsuro Shinada

    Journal of Natural Products   85 ( 4 )   1052 - 1058   2022.02（ ISSN:0163-3864 ）

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    Authorship：Lead author   Publishing type：Research paper (scientific journal)   International / domestic magazine：International journal  

    Collective total syntheses of trans-anhydromevalonic acid (tAHMA) and trans-anhydromevalonyl (tAHM) group-containing natural products (pestalotiopin A, pestalotiopamide C, pestalotiopamide D, farinomalein E, eleutherazine B, and trichocyclodipeptide A) were achieved using tAHMA esters as key intermediates. To this end, tAHMA tert-butyl ester was newly prepared by Z-vinyltosylation of tert-butyl 3-oxo-5-((triisopropylsilyl)oxy)pentanoate followed by the Negishi cross-coupling reaction with Me2Zn. tAHMA esters were converted to the target natural products via esterification or amidation. Comparison of the spectroscopic data of synthetic and natural products confirmed the E-configuration of the tAHM moieties in the natural products.

    DOI： 10.1021/acs.jnatprod.1c01176

    PubMed

  • A heterogeneous bifunctional silica-supported Ag<sub>2</sub>O/Im<sup>+</sup>Cl<sup>−</sup> catalyst for efficient CO<sub>2</sub> conversion Reviewed

    Sangita Karanjit, Emiko Tanaka, Lok Kumar Shrestha, Atsushi Nakayama, Katsuhiko Ariga, Kosuke Namba

    Catalysis Science &amp; Technology   12 ( 12 )   3778 - 3785   2022（ ISSN:2044-4753 ）

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    Publishing type：Research paper (scientific journal)   International / domestic magazine：International journal  

    Reusable heterogeneous bifunctional silica-supported Ag<sub>2</sub>O/Im<sup>+</sup>Cl<sup>−</sup> catalyst in carboxylative cyclization reaction of propargyl alcohols by the efficient utilization of CO<sub>2</sub> under ambient conditions.

    DOI： 10.1039/d2cy00194b

  • Total Synthesis and Structure Confirmation of trans-Anhydromevalonate-5-phosphate, a Key Biosynthetic Intermediate of the Archaeal Mevalonate Pathway Reviewed

    Yoko Yasuno, Atsushi Nakayama, Kai Saito, Kohei Kitsuwa, Hironori Okamura, Mutsumi Komeyama, Hisashi Hemmi, Tetsuro Shinada

    American Chemical Society (ACS)　Journal of Natural Products   84 ( 10 )   2749 - 2754   2021.10（ ISSN:0163-3864 ）

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  • Selective oxidation of alcohol-d1 to aldehyde-d1 using MnO2 Reviewed

    Hironori Okamura, Yoko Yasuno, Atsushi Nakayama, Katsushi Kumadaki, Kohei Kitsuwa, Keita Ozawa, Yusaku Tamura, Yuki Yamamoto, Tetsuro Shinada

    Royal Society of Chemistry (RSC)　RSC Advances   11 ( 46 )   28530 - 28534   2021.08

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    A facile method for deutrium incorporation into aldehydes by mild reduction of NaBD4 of aldehydes and MnO2 oxidation (98% D) is disclosed.

    DOI： 10.1039/d1ra05405h

  • Development of a novel antioxidant based on a dimeric dihydroisocoumarin derivative Reviewed

    Atsushi Nakayama, Tenta Nakamura, Tabassum Ara, Tatsuya Fukuta, Sangita Karanjit, Takeshi Harada, Asuka Oda, Hideo Sato, Masahiro Abe, Kentaro Kogure, Kosuke Namba

    Elsevier BV　Tetrahedron Letters   74   153176 - 153176   2021.06（ ISSN:0040-4039 ）

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  • Development of a mugineic acid family phytosiderophore analog as an iron fertilizer. Reviewed

    Motofumi Suzuki, Atsumi Urabe, Sayaka Sasaki, Ryo Tsugawa, Satoshi Nishio, Haruka Mukaiyama, Yoshiko Murata, Hiroshi Masuda, May Sann Aung, Akane Mera, Masaki Takeuchi, Keijo Fukushima, Michika Kanaki, Kaori Kobayashi, Yuichi Chiba, Binod Babu Shrestha, Hiromi Nakanishi, Takehiro Watanabe, Atsushi Nakayama, Hiromichi Fujino, Takanori Kobayashi, Keiji Tanino, Naoko K Nishizawa, Kosuke Namba

    Nature communications   12 ( 1 )   1558 - 1558   2021.03

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    Iron (Fe) is an essential nutrient, but is poorly bioavailable because of its low solubility in alkaline soils; this leads to reduced agricultural productivity. To overcome this problem, we first showed that the soil application of synthetic 2'-deoxymugineic acid, a natural phytosiderophore from the Poaceae, can recover Fe deficiency in rice grown in calcareous soil. However, the high cost and poor stability of synthetic 2'-deoxymugineic acid preclude its agricultural use. In this work, we develop a more stable and less expensive analog, proline-2'-deoxymugineic acid, and demonstrate its practical synthesis and transport of its Fe-chelated form across the plasma membrane by Fe(III)•2'-deoxymugineic acid transporters. Possibility of its use as an iron fertilizer on alkaline soils is supported by promotion of rice growth in a calcareous soil by soil application of metal free proline-2'-deoxymugineic acid.

    DOI： 10.1038/s41467-021-21837-6

    PubMed

  • Stereoselective Synthesis of (2S,6R)-Diamino-(5R,7)-dihydroxy-heptanoic Acid (DADH): An Unusual Amino Acid from Streptomyces sp. SANK 60404 Reviewed

    Okamura Hironori, Yasuno Yoko, Nakayama Atsushi, Takikawa Hirosato, Shinada Tetsuro

    EUROPEAN JOURNAL OF ORGANIC CHEMISTRY   2021 ( 9 )   1396 - 1401   2021.03（ ISSN:1434-193X ）

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.1002/ejoc.202001646

  • 多剤耐性真菌を克服する海洋性マイクロバイオーム由来天然物 Reviewed

    中山 淳

    公益社団法人 日本薬学会　ファルマシア   57 ( 7 )   668 - 668   2021（ ISSN:0014-8601 ）

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    Kind of work：Single Work  

    感染性真菌症は，人類の健康に対する世界的な脅威であり，現在年間約200万人の罹患者が死亡している．最近では毒性が高く，汎用抗真菌剤に耐性を獲得した「キラー真菌」<i>Candida</i> <i>auris</i>も世界中に蔓延しており，米国疾病対策予防センターから緊急警報が出されている．このような状況を打開すべく，耐性菌に有効な新規抗真菌剤の開発が望まれており，未利用の天然資源の開拓や新たなスクリーニング法の開発によって天然物由来抗真菌剤の開発が再勃興している．今回，Zhangらが海洋性マイクロバイオーム(細菌叢)から有望な新規抗真菌化合物turbinmicinを見いだしたので紹介する．<br>なお，本稿は下記の文献に基づいて，その研究成果を紹介するものである.<br>1) Zhang F. <i>et</i> <i>al</i>., <i>Science</i>, <b>370</b>, 974-978(2020)．<br>2) Chanana S. <i>et</i> <i>al</i>., <i>Metabolites</i>, <b>10</b>, 297(2020)．

    DOI： 10.14894/faruawpsj.57.7_668

    CiNii Article

  • Efficient construction of the hexacyclic ring core of palau'amine: the pKa concept for proceeding with unfavorable equilibrium reactions Reviewed

    Eisaku Ohashi, Sangita Karanjit, Atsushi Nakayama, Kohei Takeuchi, Sherif E. Emam, Hidenori Ando, Tatsuhiro Ishida, Kosuke Namba

    Royal Society of Chemistry (RSC)　Chemical Science   12 ( 36 )   12201 - 12210   2021（ ISSN:2041-6520 ）

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    A palau'amine analog (2) was synthesized from 2-cyclopentenone in 20 steps. The construction of the CDE tricyclic ring core in a single step is achieved by our p<italic>K</italic>a concept for proceeding with the unfavorable equilibrium reactions.

    DOI： 10.1039/d1sc03260g

  • Stereoselective Synthesis of (2s,3r)- and (2s,3s)-2-Amino-3-(3,4-Dihydroxyphenyl)-3-Hydroxypropanoic Acid Reviewed

    Yoko Yasuno, Shunsuke Yamaguchi, Yuma Karita, Kenta Sakai, Hironori Okamura, Atsushi Nakayama, Tetsuro Shinada

    Heterocycles   2021

  • Total Synthesis of (±)-Tronocarpine Reviewed

    Atsushi Nakayama

    Georg Thieme Verlag KG　Synfacts   16 ( 12 )   1383 - 1383   2020.12（ ISSN:1861-1958 ）

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    Kind of work：Single Work  

    DOI： 10.1055/s-0040-1719534

  • Hydrotalcite-Supported Ag/Pd Bimetallic Nanoclusters Catalyzed Oxidation and One-pot Aldol Reaction in Water Reviewed

    Sangita Karanjit, Ayumu Tamura, Masaya Kashihara, Kazuki Ushiyama, Lok, Kumar Shrestha, Katsuhiko Ariga, Atsushi Nakayama, Kosuke Namba

    Catalysts   2020.09

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.3390/catal10101120

  • Concise Total Synthesis of Tronocarpine Reviewed

    Atsushi Nakayama, Tenta Nakamura, Toshihiro Zaima, Saho Fujimoto, Sangita Karanjit, Kosuke Namba

    Angewandte Chemie International Edition   2020.09

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    Authorship：Lead author,　Corresponding author   Publishing type：Research paper (scientific journal)   International / domestic magazine：International journal  

    DOI： 10.1002/anie.202009966

  • Synthesis and evaluation of 1,1,7,7-tetramethyl-9-azajulolidine (TMAJ) as a highly active derivative of N,N-dimethylaminopyridine Reviewed

    Tomohiro Tsutsumi, Arisa Saitoh, Tomoyo Kasai, MengYue Chu, Sangita Karanjit, Atsushi Nakayama, Kosuke Namba

    Elsevier BV　Tetrahedron Letters   61 ( 26 )   152047 - 152050   2020.06（ ISSN:0040-4039 ）

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.tetlet.2020.152047

  • Bioprospecting of antibacterial constituents from the endolichenic fungi isolated from Parmotrema rampoddense Reviewed

    Mario A. Tan*, Sarleen G. Castro, Patricia Marie P. Oliva, Paul Raymund J. Yap, Atsushi Nakayama, Hilbert D. Magpantay, Thomas Edison E. dela Cruz*

    3Biotec   in press   2020.04

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    Publishing type：Research paper (scientific journal)   Kind of work：Single Work  

  • Synthesis and Antimicrobial Evaluation of Side-Chain Derivatives based on Eurotiumide A. Reviewed

    Atsushi Nakayama, Hideo Sato, Tenta Nakamura, Mai Hamada, Shuji Nagano, Shuhei Kameyama, Yui Furue, Naoki Hayashi, Go Kamoshida, Sangita Karanjit, Masataka Oda, Kosuke Namba

    Marine drugs   18 ( 2 )   92   2020.01

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    Publishing type：Research paper (scientific journal)  

    Side-chain derivatives of eurotiumide A, a dihydroisochroman-type natural product, have been synthesized and their antimicrobial activities described. Sixteen derivatives were synthesized from a key intermediate of the total synthesis of eurotiumide A, and their antimicrobial activities against two Gram-positive bacteria, methicillin-susceptible and methicillin-resistant Staphylococcus aureus (MSSA and MRSA), and a Gram-negative bacterium, Porphyromonas gingivalis, were evaluated. The results showed that derivatives having an iodine atom on their aromatic ring instead of the prenyl moiety displayed better antimicrobial activity than eurotiumide A against MSSA and P. gingivalis. Moreover, we discovered that a derivative with an isopentyl side chain, which is a hydrogenated product of eurotiumide A, is the strongest antimicrobial agent against all three strains, including MRSA.

    DOI： 10.3390/md18020092

    PubMed

  • Development of a 1,3a,6a-triazapentalene derivative as a compact and thiol-specific fluorescent labeling reagent Reviewed

    Atsushi Nakayama, Akira Otani, Tsubasa Inokuma, Daisuke Tsuji, Haruka Mukaiyama, Akira Nakayama, Kohji Itoh, Akira Otaka, Keiji Tanino, Kosuke Namba

    Communications Chemistry   3 ( 6 )   2020.01

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    Publishing type：Research paper (scientific journal)   Kind of work：Joint Work  

  • Total Syntheses and Medicinal Studies of Dihydroisocoumarin-type Natural Products Reviewed

    Atsushi Nakayama

    CHEMICAL INDUSTRY   71 ( 2 )   83 - 91   2020.01

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    Publishing type：Research paper (scientific journal)   Kind of work：Single Work  

  • Diversity-oriented Symposium: Diversity Experiences through Study Abroad Reviewed

    Fumika Yakushiji, Atsushi Nakayama

    YAKUGAKU ZASSHI   140 ( 1 )   23 - 24   2020.01

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    Publishing type：Research paper (scientific journal)  

  • Development of a 1,3a,6a-triazapentalene derivative as a compact and thiol-specific fluorescent labeling reagent Reviewed

    Atsushi Nakayama, Akira Otani, Tsubasa Inokuma, Daisuke Tsuji, Haruka Mukaiyama, Akira Nakayama, Kohji Itoh, Akira Otaka, Keiji Tanino, Kosuke Namba

    Communications Chemistry   3   6   2020.01

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    Authorship：Lead author   Publishing type：Research paper (scientific journal)  

    DOI： 10.1038/s42004-019-0250-0

  • Asymmetric Total Syntheses and Structure Elucidations of (+)-Eurotiumide F and (+)-Eurotiumide G Reviewed

    Atsushi Nakayama

    Chemical & Pharmaceutical Bulletin   67   953 - 958   2019.06

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    Publishing type：Research paper (scientific journal)  

  • Microwave-assisted Tertiary Carbon Radical Reaction for Construction of Quaternary Carbon Center Reviewed

    Ryota Sato, Ryuji Okamoto, Takumi Ishizuka, Atsushi Nakayama, Sangita Karanjit, Kosuke Namba

    Chemistry Letters   48 ( 5 )   414 - 417   2019.05（ ISSN:0366-7022 ）

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.1246/cl.190040

  • A Concise Asymmetric Total Synthesis of (+)-Epilupinine. Reviewed

    Tsutsumi T, Karanjit S, Nakayama A, Namba K

    Organic letters   21 ( 8 )   2620 - 2624   2019.04（ ISSN:1523-7060 ）

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.1021/acs.orglett.9b00607

    PubMed

  • Synthesis and Evaluation of a 1,3a,6a-Triazapentalene (TAP)-Bonded System Reviewed

    Ito Masami, Mera Akane, Mashimo Takaki, Seki Tomohiro, Karanjit Sangita, Ohashi Eisaku, Nakayama Atsushi, Kitamura Kei, Hamura Toshiyuki, Ito Hajime, Namba Kosuke

    CHEMISTRY-A EUROPEAN JOURNAL   24 ( 67 )   17727 - 17733   2018.12（ ISSN:0947-6539 ）

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.1002/chem.201804733

  • Asymmetric Total Syntheses and Structure Revisions of Eurotiumide A and Eurotiumide B, and Their Evaluation as Natural Fluorescent Probes Reviewed

    Nakayama Atsushi, Sato Hideo, Karanjit Sangita, Hayashi Naoki, Oda Masataka, Namba Kosuke

    EUROPEAN JOURNAL OF ORGANIC CHEMISTRY   ( 29 )   4013 - 4017   2018.08（ ISSN:1434-193X ）

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.1002/ejoc.201800535

  • Direct Synthesis of Polycyclic Tropinones by a Condensation-[4+3]-Cycloaddition Cascade Reaction Reviewed

    Okamoto Tsubasa, Shibata Miki, Karanjit Sangita, Nakayama Atsushi, Yoshida Masahiro, Namba Kosuke

    CHEMISTRY-A EUROPEAN JOURNAL   24 ( 38 )   9508 - 9513   2018.07（ ISSN:0947-6539 ）

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.1002/chem.201802011

  • Highly active and reusable hydrotalcite-supported Pd(0) catalyst for Suzuki coupling reactions of aryl bromides and chlorides Reviewed

    Sangita Karanjit, Masaya Kashihara, Atsushi Nakayama, Lok Kumar Shrestha, Katsuhiko Ariga, Kosuke Namba

    Elsevier Ltd　Tetrahedron   74 ( 9 )   948 - 954   2018.03（ ISSN:1464-5416 ）

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    Publishing type：Research paper (scientific journal)  

    A palladium(0) nanocluster supported on hydrotalcite has been prepared and tested for the Suzuki coupling reaction. The prepared catalyst showed very efficient catalytic activity for cross coupling of iodo- and bromoarenes under very mild reaction conditions, affording &gt
    90% yield. Under the optimized reaction conditions, chloroarenenes also showed very good reactivity. Transmission electron microscopic imaging data showed the formation of very small Pd(0)-nanoclusters (d = 2.2 ± 0.5 nm) well dispersed on the support, which enhanced the activity and stability of the catalyst for the Suzuki cross-coupling reaction. This catalytic system offers an easy method of preparation with good activity and reusability up to five cycles.

    DOI： 10.1016/j.tet.2017.12.056

  • Asymmetric total syntheses and structure revision of eurotiumide A and B, and evaluation of their fluorescent properties as natural probes Reviewed

    Atsushi Nakayama

    Society of Synthetic Organic Chemistry　Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry   76 ( 5 )   498 - 501   2018（ ISSN:0037-9980 ）

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    Publishing type：Research paper (scientific journal)   Kind of work：Single Work  

    Asymmetric total syntheses and structure revision of dihydroisocoumarin-type natural products, eurotiumide A and eurotiumide B have been described. Key features of these total syntheses are the asymmetric Shi epoxidation, regioselective epoxide opening, and Pd-catalyzed CO insertion-lactonization cascade reaction to construct 4-methoxyisochroman-1-one skeleton. X-ray crystallographic analysis of the key intermediate revealed the absolute configuration and relative structure of eurotiumides, and it revised the reported structures of eurotiumide A and B, respectively. These natural products also exhibited highly fluorescence with several solvents with large Stokes shift.

    DOI： 10.5059/yukigoseikyokaishi.76.498

  • Development of 1,3a,6a-triazapentalene-labeled enterobactin as a fluorescence quenching sensor of iron ion Reviewed

    Tsukiho Hayashi, Ayumi Osawa, Takehiro Watanabe, Yoshiko Murata, Atsushi Nakayama, Kosuke Namba

    PERGAMON-ELSEVIER SCIENCE LTD　TETRAHEDRON LETTERS   58 ( 20 )   1961 - 1964   2017.05（ ISSN:0040-4039 ）

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    Publishing type：Research paper (scientific journal)  

    1,3a,6a-Triazapentalene (TAP)-labeled enterobactin was developed as an iron ion sensor. 3-Acetylated-TAP was successfully introduced to the catechol ring of enterobactin, a well-recognized siderophore secreted by various Gram-negative bacteria. The fluorescence of TAP-labeled enterobactin decreased gradually as the amount of Fe3+ ion as an additive was increased, and 1.2 equiv of Fe3+ ion completely quenched the fluorescence. In clear contrast, when other metal ions were used, the fluorescence of TAP-labeled enterobactin remained even at 5.0 equiv. (C) 2017 Elsevier Ltd. All rights reserved.

    DOI： 10.1016/j.tetlet.2017.04.011

  • Synthesis of 2,6-Disubstituted-1,3a, 6a-Triazapentalenes and Their Fluorescence Properties Reviewed

    Akane Mera, Masami Ito, Atsushi Nakayama, Kosuke Namba

    CHEMICAL SOC JAPAN　CHEMISTRY LETTERS   46 ( 4 )   539 - 542   2017.04（ ISSN:0366-7022 ）

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    Publishing type：Research paper (scientific journal)  

    The substituent effect at the C6-position of 1,3a,6a-triazapentalenes was elucidated. Synthesis of C6-substituted-1,3a, 6a-triazapentalene was established by an epoxide-opening reaction of the 1,2,3-triazoles followed by elimination of the resulting hydroxy group. The electron-donating substituent induced a longer-wavelength shift of the fluorescence maximum and change of the fluorescence quantum yield depending on the C2-substituents. On the other hand, the electron-withdrawing group quenched the fluorescence of 1,3a, 6a-triazapentalenes.

    DOI： 10.1246/cl.170078

  • 極小蛍光分子を用いた実践的キナーゼ阻害薬の探索研究 Reviewed

    中山 淳

    (公財)上原記念生命科学財団　上原記念生命科学財団研究報告集   30   1 - 5   2016.12

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    Publishing type：Research paper (scientific journal)   Kind of work：Single Work  

    in vivo、in vitro系で既に良好な治療効果をあげたものに、蛍光残基を導入した光標識プローブ2を設計し、蛍光を目印としたアッセイ系確立を目指し、候補化合物のスクリーニングを高速化できると考え、極小蛍光分子を用いた実践的キナーゼ阻害薬を探索した。A、B、C各ユニット合成を行い、Aユニットは市販の2,4,6-トリヒドロキシ安息香酸を出発原料に、3工程でトリフラート体9に導き、鈴木-宮浦カップリングにより収率よくスチレン誘導体に変換後、エステル加水分解を経て、Aユニット合成を完了した。Bユニットは2-デオキシ-D-リボースからジオールのアセトナイド保護、Wittig反応、Parikh-Doering酸化を行い、アルデヒド14を得ることができた。Cユニットについては、市販の光学活性(S)-プロピレンオキサイドからリチウムアセリドによる開環と、生じた水酸基をTBDPS基で保護することで合成を行った。

  • Facile Guanidine Formation under Mild Acidic Conditions Reviewed

    Kohei Takeuchi, Atsushi Nakayama, Keiji Tanino, Kosuke Namba

    GEORG THIEME VERLAG KG　SYNLETT   27 ( 18 )   2591 - 2596   2016.11（ ISSN:0936-5214 ）

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    Publishing type：Research paper (scientific journal)  

    An efficient method for converting isothioureas into guanidines was developed. The use of amine salts of bis(trifluoromethanesulfonyl)imide as a nitrogen source was found to induce an efficient conversion under weak acidic conditions at 50 degrees C. The conversion was applicable to the various amines and carbamate-protected thioureas, and various carbamate-protected cyclic guanidines were obtained in high yields. In particular, ammonium bis(trifluoromethanesulfonyl)imide salt is a useful N1 source with which to construct monoprotected cyclic guanidines.

    DOI： 10.1055/s-0035-1562478

  • Synthesis of functionalized 2,3-dihydropyrroles by oxidative radical cyclization of N-Sulfonyl beta-enamino esters with alkenes Reviewed

    Masahiro Yoshida, Asuka Kobayashi, Atsushi Nakayama, Kosuke Namba

    PERGAMON-ELSEVIER SCIENCE LTD　TETRAHEDRON   72 ( 20 )   2544 - 2551   2016.05（ ISSN:0040-4020 ）

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    Publishing type：Research paper (scientific journal)  

    Oxidative radical cyclization of N-sulfonyl beta-enamino esters with alkenes has been developed. Substituted 2,3-dihydropyrroles were produced when the reactions were carried out in the presence of CAN and Cu(OAc)(2) as the oxidant. Intramolecular cyclization of beta-enamino carbonyl compounds having an alkenyl and an alkynyl side chain proceeded to afford the corresponding bicyclic products, respectively. (C) 2016 Elsevier Ltd. All rights reserved.

    DOI： 10.1016/j.tet.2016.03.055

  • Substituent Effect at C4-Position of 1,3a,6a-Triazapentalene Reviewed

    Atsushi Nakayama, Nishio Satoshi, Otani Akira, Mera Akane, Osawa Ayumi, Tanino keiji, Kosuke Namba

    Chemical & Pharmaceutical Bulletin   Vol.64 ( No.7 )   830 - 837   2016.04（ ISSN:1347-5223 ）

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    Publishing type：Research paper (scientific journal)  

    Various 2,4-disubstituted-1,3a,6a-triazapentalenes possessing methyl and phenyl groups at the C4-position were synthesized. Fluorescence observation of the synthetic 4-methyl- and 4-phenyl-1,3a,6a-triazapentalenes revealed that the introduction of a substituent at the C4-position allowed a long-wavelength shift of the fluorescence maximum. Furthermore, the phenyl group at the C4-position was found to induce a substantial increase in the extinction coefficient value.

    DOI： 10.1248/cpb.c16-00196

    PubMed

  • Total synthesis of palau'amine Reviewed

    Kosuke Namba, Kohei Takeuchi, Yukari Kaihara, Masataka Oda, Akira Nakayama, Atsushi Nakayama, Masahiro Yoshida, Keiji Tanino

    NATURE PUBLISHING GROUP　NATURE COMMUNICATIONS   6   2015.11（ ISSN:2041-1723 ）

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    Palau'amine has received a great deal of attention in the past two decades as an attractive synthetic target by virtue of its intriguing molecular architecture and significant immunosuppressive activity. Here we report the total synthesis of palau'amine characterized by the construction of an ABDE tetracyclic ring core including a trans-bicylo[3.3.0] octane skeleton at a middle stage of total synthesis. The ABDE tetracyclic ring core is constructed by a cascade reaction of a cleavage of the N-N bond, including simultaneous formation of imine, the addition of amide anion to the resulting imine (D-ring formation) and the condensation of pyrrole with methyl ester (B-ring formation) in a single step. The synthetic palau'amine is confirmed to exhibit excellent immunosuppressive activity. The present synthetic route has the potential to help elucidate a pharmacophore as well as the mechanistic details of immunosuppressive activity.

    DOI： 10.1038/ncomms9731

  • Total Syntheses and Initial Evaluation of [Psi[C(=S)NH]Tpg(4)]vancomycin, [Psi[C(=NH)NH]Tpg(4)]vancomycin, [Psi[CH2NH]Tpg(4)]vancomycin, and Their (4-Chlorobiphenyl)methyl Derivatives: Synergistic Binding Pocket and Peripheral Modifications for the Glycopeptide Antibiotics Reviewed

    Akinori Okano, Atsushi Nakayama, Kejia Wu, Erick A. Lindsey, Alex W. Schammel, Yiqing Feng, Karen C. Collins, Dale L. Boger

    AMER CHEMICAL SOC　JOURNAL OF THE AMERICAN CHEMICAL SOCIETY   137 ( 10 )   3693 - 3704   2015.03（ ISSN:0002-7863 ）

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    Full details of studies are disclosed on the total syntheses of binding pocket analogues of vancomycin bearing the peripheral L-vancosaminyl-1,2-D-glucosyl disaccharide that contain changes to a key single atom in the residue-4 amide (residue-4 carbonyl O -&gt; S, NH, H-2) designed to directly address the underlying molecular basis of resistance to vancomycin. Also disclosed are studies piloting the late-stage transformations conducted on the synthetically more accessible C-terminus hydroxymethyl aglycon derivatives and full details of the peripheral chlorobiphenyl functionalization of all of the binding-pocket-modified vancomycin analogues designed for dual D-Ala-D-Ala/D-Ala-D-Lac binding. Their collective assessment indicates that combined binding pocket and chlorobiphenyl peripherally modified analogues exhibit a remarkable spectrum of antimicrobial activity (VSSA, MRSA, and VanA. and VanB VRE) and impressive potencies against both vancomycin-sensitive and vancomycin-resistant bacteria (MICs = 0.06-0.005 and 0.5-0.06 mu g/mL for the amidine and methylene analogues, respectively) and likely benefit from two independent and synergistic mechanisms of action, only one of which is dependent on D-Ala-D-Ala/D-Ala-D-Lac binding. Such analogues are likely to display especially durable antibiotic activity that is not prone to rapidly acquired clinical resistance.

    DOI： 10.1021/jacs.5b01008

  • Total Synthesis of [Psi[C(=NH)NH]Tpg(4)]Vancomycin and its ((4)-Chlorobiphenyl)methyl Derivative: Impact of Peripheral Modifications on Vancomycin Analogues Redesigned for Dual D-Ala-D-Ala and D-Ala-D-Lac Binding Reviewed

    Akinori Okano, Atsushi Nakayama, Alex W. Schammel, Dale L. Boger

    AMER CHEMICAL SOC　JOURNAL OF THE AMERICAN CHEMICAL SOCIETY   136 ( 39 )   13522 - 13525   2014.10（ ISSN:0002-7863 ）

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    The total synthesis of two key analogues of vancomycin containing single-atom exchanges in the binding pocket (residue 4 amidine and thioamide) are disclosed as well as their peripherally modified (4-chlorobiphenyl)methyl (CBP) derivatives. Their assessment indicates that combined pocket amidine and CBP peripherally modified analogues exhibit a remarkable spectrum of antimicrobial activity (VSSA, MRSA, VanA and VanB VRE) and impressive potencies (MIC = 0.060.005 mu g/mL) against both vancomycin-sensitive and -resistant bacteria and likely benefit from two independent and synergistic mechanisms of action. Like vancomycin, such analogues are likely to display especially durable antibiotic activity not prone to rapidly acquired clinical resistance.

    DOI： 10.1021/ja507009a

  • Enzymatic Glycosylation of Vancomycin Aglycon: Completion of a Total Synthesis of Vancomycin and N- and C-Terminus Substituent Effects of the Aglycon Substrate Reviewed

    Atsushi Nakayama, Akinori Okano, Yiqing Feng, James C. Collins, Karen C. Collins, Christopher T. Walsh, Dale L. Boger

    AMER CHEMICAL SOC　ORGANIC LETTERS   16 ( 13 )   3572 - 3575   2014.07（ ISSN:1523-7060 ）

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    Studies on the further development of the sequential glycosylations of the vancomycin aglycon catalyzed by the glycosyltransferases GtfE and GtfD and the observation of unusual, perhaps unexpected, aglycon substrate substituent effects on the rate and efficiency of the initial glycosylation reaction are reported.

    DOI： 10.1021/ol501568t

  • Syntheses of Fawcettimine-Type Lycopodium Alkaloids Utilizing the Pauson-Khand Reaction Reviewed

    Atsushi Nakayama, Mariko Kitajima, Hiromitsu Takayama

    GEORG THIEME VERLAG KG　SYNLETT   ( 14 )   2014 - 2024   2012.09（ ISSN:0936-5214 ）

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    The asymmetric total syntheses of some fawcettimine-type Lycopodium alkaloids, utilizing an intramolecular Pauson-Khand reaction as the key step, are described.

    DOI： 10.1055/s-0032-1316680

  • Asymmetric Total Synthesis of a Pentacyclic Lycopodium Alkaloid: Huperzine-Q Reviewed

    Atsushi Nakayama, Noriyuki Kogure, Mariko Kitajima, Hiromitsu Takayama

    WILEY-BLACKWELL　ANGEWANDTE CHEMIE-INTERNATIONAL EDITION   50 ( 35 )   8025 - 8028   2011（ ISSN:1433-7851 ）

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  • First Asymmetric Total Syntheses of Fawcettimine-Type Lycopodium Alkaloids, Lycoposerramine-C and Phlegmariurine-A Reviewed

    Atsushi Nakayama, Noriyuki Kogure, Mariko Kitajima, Hiromitsu Takayama

    AMER CHEMICAL SOC　ORGANIC LETTERS   11 ( 23 )   5554 - 5557   2009.12（ ISSN:1523-7060 ）

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    A successful asymmetric total synthesis of lycoposerramine-C involving such key steps as a cobalt-mediated Pauson-Khand reaction and vinyl Claisen rearrangement and its biomimetic transformation to phlegmariurine-A are described.

    DOI： 10.1021/ol902437t

  • STRAIGHTFORWARD ASYMMETRIC TOTAL SYNTHESIS OF (+)-EVODIAMINE, A MAJOR INDOLE ALKALOID IN HERBAL MEDICINE "Wu Zhu Yu" Reviewed

    Atsushi Nakayama, Noriyuki Kogure, Mariko Kitajima, Hiromitsu Takayama

    PERGAMON-ELSEVIER SCIENCE LTD　HETEROCYCLES   76 ( 1 )   861 - 865   2008.09（ ISSN:0385-5414 ）

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    The concise asymmetric total synthesis of evodiamine, an indole alkaloid in Evodia Fructus, was achieved by employing Noyori&apos;s ruthenium(II)-catalyzed asymmetric transfer hydrogenation.

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Books and Other Publications

MISC

  • Synthesis of 1,3a,6a-Triazapentalene derivatives and evaluation of those photoresponsive cytotoxicity Reviewed

    山本璃子, 長野秀嗣, 米良茜, KARANJIT Sangita, 中山淳, 辻大輔, 辻大輔, 赤木玲子, 伊藤孝司, 難波康祐

    日本薬学会年会要旨集(Web)   143rd   2023（ ISSN:0918-9823 ）

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    Publishing type：Article, review, commentary, editorial, etc. (scientific journal)  

    J-GLOBAL

  • 対称ジスルフィドから非対称ジスルフィドへ　硫黄-酸素結合の解離エネルギーを巧みに利用 Invited Reviewed

    中山　淳

    化学同人　化学   76 ( 1 )   66 - 67   2021.01

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    Publishing type：Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)   Kind of work：Single Work  

  • 重水素化アルデヒドの簡便合成 Reviewed

    品田哲郎, 熊懐克志, 橘和航平, 小澤圭太, 田村優作, 山本悠生, 中山淳, 岡村仁則, 保野陽子

    創薬懇話会講演要旨集   2021   2021

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    Publishing type：Article, review, commentary, editorial, etc. (scientific journal)  

    J-GLOBAL

  • イネ科植物の鉄イオン取り込み機構解明のためのトランスポーター標識プローブの開発 Reviewed

    船曵早希, 佐々木彩花, 向山はるか, 辻大輔, 村田佳子, 山本武範, SANGITA Karanjit, 中山淳, 伊藤孝司, 難波康祐

    創薬懇話会講演要旨集   2021   2021

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    Publishing type：Article, review, commentary, editorial, etc. (scientific journal)  

    J-GLOBAL

  • Synthesis and evaluation of labeling probe for iron uptake transporter in gramineous plant Reviewed

    船曵早希, 佐々木彩花, 向山はるか, 辻大輔, 村田佳子, 山本武範, KARANJIT Sangita, 中山淳, 伊藤孝司, 難波康祐

    日本薬学会年会要旨集(CD-ROM)   140th (Web)   2020

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    Publishing type：Article, review, commentary, editorial, etc. (scientific journal)  

    J-GLOBAL

  • 天然マクロライドの全合成が拓く新規多発性骨髄腫治療薬 Reviewed

    浜田麻衣, 森崎巧也, 中山淳, 寺町順平, 辻大輔, 重永章, 山本武範, 篠原康雄, 大高章, 伊藤孝司, 安部正博, 難波康祐

    創薬懇話会講演要旨集   2019   2019

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    Publishing type：Article, review, commentary, editorial, etc. (scientific journal)  

    J-GLOBAL

  • Resorcylic Acid Lactonesを基盤とした新規骨髄腫治療薬の創製研究 Reviewed

    中山淳, 浜田麻衣, 中山慎一朗, 森崎巧也, 寺町順平, 辻大輔, 重永章, 大高章, 伊藤孝司, 安部正博, 難波康祐

    反応と合成の進歩シンポジウム講演要旨集   45th   2019（ ISSN:0919-2123 ）

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    Publishing type：Article, review, commentary, editorial, etc. (scientific journal)  

    J-GLOBAL

  • ファルマシア　トピックス Invited Reviewed

    中山　淳

    日本薬学会・ファルマシア   2012.03

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    Publishing type：Article, review, commentary, editorial, etc. (scientific journal)   Kind of work：Single Work  

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Presentations

  • Guaianolide型セスキテルペンラクトン類の全合成 Domestic conference

    木村 有希, 大橋 栄作, 迫頭 春子, 中山 淳, 難波 康祐

    日本薬学会第141年会  2021.03 

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    Presentation type：Oral presentation (general)  

  • Calyciphylline Fの全合成研究 Domestic conference

    井上 雅貴, 佐藤 亮太, 古高 涼太, 中山 淳, Karanjit Sangita, 難波 康祐

    日本薬学会第141年会  2021.03 

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    Presentation type：Oral presentation (general)  

  • Chippiine型アルカロイドTronocarpineの短工程全合成 Domestic conference

    中村 天太, 戝間 俊宏, Karanjit Sangita, 中山 淳, 難波 康祐

    日本薬学会第141年会  2021.03 

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    Presentation type：Oral presentation (general)  

  • アンヒドロメバロン酸類の立体選択的合成 Domestic conference

    橘和 航平, 齋藤 甲斐, 中山 淳, 岡村 仁則, 保野 陽子, 品田 哲郎

    日本化学会　第101春季年会（2021）  2021.03 

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    Presentation type：Oral presentation (general)  

  • アルデヒドの簡便な重水素化法の開発と重水素化鎖状テルペン合成への応用 Domestic conference

    品田 哲郎, 保野 陽子, 岡村 仁則, 中山 淳, 熊懐 克志, 橘和 航平, 小澤 圭太, 田村 優作, 山本 悠生

    日本化学会　第101春季年会（2021）  2021.03 

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    Presentation type：Oral presentation (general)  

  • Development of a compact fluorescent probe based on 1,3a,6a-triazapentalene Invited International conference

    Atsushi Nakayama

    A3 foresight program: Asian Chemical Probe Research Hub 4th A3 Young Scientists Online Meeting  2021.02 

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    Presentation type：Oral presentation (invited, special)  

  • 蛍光性シデロフォアを利用した微生物検出法の開発 Domestic conference

    奥田 実沙, 米良 茜, 小田 真隆, 中山 淳, Karanjit Sangita, 難波 康祐

    日本薬学会年会要旨集  2020.03  (公社)日本薬学会

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    Presentation type：Oral presentation (general)  

  • (+)-Eurotiumide Fおよび(+)-eurotiumide Gの不斉全合成と構造訂正 Domestic conference

    中山 淳, 佐藤 次朗, 長野 秀嗣, カランジット サンギータ, 今川 洋, 難波 康祐

    第58回 日本薬学会・日本薬剤師会・日本病院薬剤師会 中国四国支部学術大会  2019.11 

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    Presentation type：Oral presentation (general)  

  • 天然物の網羅全合成を基軸とした医薬化学研究とケミカルバイオロジー Domestic conference

    中山 淳

    第189回 薬学談話会 （名古屋市立大学）  2019.10 

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    Presentation type：Oral presentation (general)  

  • Resorcylic Acid Lactonesを基盤とした新規骨髄腫治療薬の創製研究 Domestic conference

    中山 淳, 浜田 麻衣, 中山 慎一朗, 森崎 巧也, 寺町 順平, 辻 大輔, 重永 章, 大高 章, 伊藤 孝司, 安倍 正博, 難波 康祐

    第45回 反応と合成の進歩シンポジウム  2019.10 

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    Presentation type：Oral presentation (general)  

  • Synthetic Studies on Chipiine-type alkaloids Domestic conference

    Atsushi Nakayama

    27ht International Society of Heterocyclic Chemistry Congress  2019.09 

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    Presentation type：Oral presentation (general)  

  • 天然物の網羅全合成を基軸とした医薬化学研究 Domestic conference

    中山 淳

    第54回天然物化学談話会  2019.07 

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    Presentation type：Oral presentation (general)  

  • 新規Ynone化合物の創生・評価 Domestic conference

    浜田 麻衣, 森崎 巧也, 中山 淳, 重永 章, 辻 大輔, 寺町 順平, 安部 正博, 伊藤 孝司, 大高 章, 難波 康祐

    日本薬学会年会要旨集  2019.03  (公社)日本薬学会

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    Presentation type：Oral presentation (general)  

  • ムギネ酸類の実用化研究 Domestic conference

    占部 敦美, 津川 稜, 西尾 賢, 佐々木 彩花, 鈴木 基史, 増田 寛志, Karanjit Sangita, 中山 淳, 小林 高範, 難波 康祐

    日本薬学会年会要旨集  2019.03  (公社)日本薬学会

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    Presentation type：Oral presentation (general)  

  • Asymmetric Total Syntheses of Eurotiumides Domestic conference

    Atsushi Nakayama

    4th International Symposium on Molecular Sciences (Santo Tomas University, Philippine)  2018.11 

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    Presentation type：Oral presentation (general)  

  • Asymmetric Total Syntheses of Eurotiumides Domestic conference

    Atsushi Nakayama

    International Congress on Pure & Applied Chemistry (ICPAC)2018  2018.10 

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    Presentation type：Oral presentation (general)  

  • Chippiine型アルカロイド類の全合成研究 Domestic conference

    中山 淳, 財間 俊宏, 藤本 沙帆, カランジット サンギータ, 難波 康祐

    第60回天然有機化合物討論会（久留米）  2018.09 

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    Presentation type：Oral presentation (general)  

  • Chippiine型アルカロイド類の全合成研究 Domestic conference

    中山 淳, 財間 俊宏, 藤本 沙帆, カランジット サンギータ, 難波 康祐

    第60回天然有機化合物討論会（久留米）  2018.09 

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    Presentation type：Oral presentation (general)  

  • Chippiine型アルカロイド類の全合成研究 Domestic conference

    中山 淳, 財間 俊宏, 藤本 沙帆, カランジット サンギータ, 難波 康祐

    第16回次世代を担う有機化学シンポジウム（大阪）  2018.05 

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    Presentation type：Oral presentation (general)  

  • Dippinine Bの全合成研究 Domestic conference

    中山 淳, 財間 俊宏, カランジット サンギータ, 難波 康祐

    日本薬学会第138年会 （金沢）  2018.03 

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    Presentation type：Oral presentation (general)  

  • サリチル酸系天然物Eurotiumide AとLL-Z1640-2の不斉全合成 Domestic conference

    中山 淳, 佐藤 次朗, 中山 慎一朗, Karanjit Sangita, 難波 康祐

    第111回有機合成シンポジウム（岡山）  2017.06 

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    Presentation type：Oral presentation (general)  

  • 細菌類の迅速同定を目指した蛍光標識Vibrioferrinの合成研究 Domestic conference

    米良 茜, 小田 真隆, 中山 淳, Karanjit Sangita, 難波 康祐

    日本薬学会年会要旨集  2017.03  (公社)日本薬学会

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    Presentation type：Oral presentation (general)  

  • フジツボ着床阻害活性を有する天然物Eurotiumide Bの全合成と蛍光プローブへの展開 Domestic conference

    中山 淳, 佐藤 次朗, 難波 康祐

    2017年度日本付着生物学会総会・研究集会（東京）  2017.03 

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    Presentation type：Oral presentation (general)  

  • Palau'amineの第二世代合成研究 Domestic conference

    大橋 栄作, 竹内 公平, 中山 淳, 谷野 圭持, 難波 康祐

    日本薬学会年会要旨集  2017.03  (公社)日本薬学会

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    Presentation type：Oral presentation (general)  

  • Eurotiumide類の網羅的不斉全合成研究 Domestic conference

    佐藤 次朗, 中山 慎一朗, 中山 淳, 難波 康祐

    日本薬学会年会要旨集  2017.03  (公社)日本薬学会

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    Presentation type：Oral presentation (general)  

  • Chippiine型アルカロイドDippinine Bの全合成研究 Domestic conference

    財間 俊宏, 竹内 公平, 中山 淳, 難波 康祐

    日本薬学会年会要旨集  2017.03  (公社)日本薬学会

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    Presentation type：Oral presentation (general)  

  • Calyciphylline Fの全合成研究 Domestic conference

    佐藤 亮太, 古高 涼太, 淵上 龍一, 中山 淳, 谷野 圭持, 難波 康祐

    日本薬学会年会要旨集  2017.03  (公社)日本薬学会

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    Presentation type：Oral presentation (general)  

  • (+)-Lapidilectine Bの全合成研究 Domestic conference

    牛山 和輝, 石川 雄大, 中山 淳, 須藤 宏城, 谷野 圭持, 難波 康祐

    日本薬学会年会要旨集  2017.03  (公社)日本薬学会

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    Presentation type：Oral presentation (general)  

  • Ring-Closing-Metathesis反応を利用した天然マクロライドLL-Z1640-2の不斉全合成 Domestic conference

    中山 淳, 中山 慎一朗, 難波 康祐

    第55回日本薬学会・日本薬剤師会・日本病院薬剤師会 中国四国支部学術大会（岡山）  2016.11 

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    Presentation type：Oral presentation (general)  

  • Total Synthesis and Medicinal Study of Resorcylic Acid Lactone, LL-Z1640-2 Domestic conference

    Nakyama, A, Nakayama, S, Namba, K

    The 10th International Symposium on Integrated Synthesis (ISONIS-10) (Awaji, Japan)  2016.11 

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    Presentation type：Oral presentation (general)  

  • 天然マクロライドLL-Z1640-2の不斉全合成と医薬化学研究 Domestic conference

    中山 淳, 中山 慎一朗, 難波 康祐

    第21回天然薬物の開発と応用シンポジウム（千葉）  2016.10 

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    Presentation type：Oral presentation (general)  

  • 新規骨髄腫治療剤を指向した天然マクロライドの全合成研究 Domestic conference

    中山 淳

    第32回若手化学者のための化学道場  2016.08 

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    Presentation type：Oral presentation (general)  

  • アメリカ西海岸留学体験記：Postdoc in The Scripps Research Institute Domestic conference

    中山 淳

    第51回天然物化学談話会  2016.07 

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    Presentation type：Oral presentation (general)  

  • 希少イミノ糖Fagomine類の網羅的合成研究 Domestic conference

    飯國 文香, 中山 淳, 吉田 昌裕, 難波 康祐

    日本薬学会年会要旨集  2016.03  (公社)日本薬学会

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    Presentation type：Oral presentation (general)  

  • 天然マクロライドを基盤とした新規多発性骨髄腫治療剤の創製研究 Domestic conference

    難波康祐, 中山淳

    平成２７年度革新的特色研究シンポジウム（徳島）  2016.03 

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    Presentation type：Oral presentation (general)  

  • アルキニルアジリジンの1,5-水素移動反応を鍵とする置換ピロリンの立体選択的合成 Domestic conference

    水口 智貴, 和田 文恵, 中山 淳, 難波 康祐, 吉田 昌裕

    日本薬学会年会要旨集  2016.03  (公社)日本薬学会

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    Presentation type：Oral presentation (general)  

  • TAK1阻害剤LL-Z1640-2の不斉全合成 Domestic conference

    中山 慎一朗, 中山 淳, 難波 康祐

    日本薬学会年会要旨集  2016.03  (公社)日本薬学会

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    Presentation type：Oral presentation (general)  

  • Kansuinine Aの全合成研究 Domestic conference

    林 月穂, 大澤 歩, 中山 淳, 谷野 圭持, 難波 康祐

    日本薬学会年会要旨集  2016.03  (公社)日本薬学会

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    Presentation type：Oral presentation (general)  

  • Studies of Asymmetric Total Synthesis of Fawcettimine-type Lycopodium Alkaloids Based on Cobalt mediated Pauson-Khand Reaction Domestic conference

    Atsushi Nakayama

    Santo Tomas University  2015.12 

  • 耐性菌克服を指向したバンコマイシン誘導体の創製研究 Domestic conference

    中山 淳

    平成27年度 第９回化学系若手研究者講演会, 千葉大学  2015.12 

  • Total Synthesis and SAR studies of Anti-tumor agent, LL-Z1640-2 Domestic conference

    Atsushi Nakayama

    20th Annual Natural products Society of the Philippines Convention  2015.12 

  • 耐性菌克服を指向した[ψ[C=(NH)NH]Tpg4]vancomycin 誘導体の創製研究 Domestic conference

    中山 淳, Akinori Okano, Yiqing Feng, Alex, W. Schammel, Dale L. Boger

    第33回メディシナルケミストリーシンポジウム（千葉）  2015.11 

  • 耐性菌克服を指向したバンコマイシン誘導体の創製研究 Domestic conference

    中山 淳

    平成26年度第二回化学系若手研究者講話、明治薬科大学  2014.12 

  • Enzymatic Glycosylation of Vancomycin Aglycon: Completion of a Total Synthesis of Vancomycin and N- and C-Terminus Substituent Effects of the Aglycon Substrate Domestic conference

    Atsushi Nakayama, Akinori Okano, Feng Yiqing, Collins C. James, Collins C. Karen, Walsh T. Christopher, Boger L. Dale

    Enzymatic Glycosylation of Vancomycin Aglycon: Completion of a Total Synthesis of Vancomycin and N- and C-Terminus Substituent Effects of the Aglycon Substrate  2014.09 

  • 天然物化学を基盤としたアルカロイド類及びグリコペプチド類の不斉全合成研究 Domestic conference

    中山 淳

    徳島大学若手研究者講演会、徳島大学  2014.01 

  • Pauson-Khand反応を基盤としたfawcettimineの不斉全合成研究 Domestic conference

    中山淳, 小暮紀行, 北島満里子, 高山廣光

    日本薬学会第132年会 (札幌)  2012.03 

  • Synthetic Studies of Fawcettimine-Type Lycopodium Alkaloids Domestic conference

    Atsushi Nakayama, Noriyuki Kogure, Mariko Kitajima, Hiromitsu Takayama

    The 1st Junior International Conference on Cutting-Edge Organic Chemistry in Asia (Xiamen, China)  2011.12 

  • Synthetic Studies of Fawcettimine-Type Lycopodium Alkaloids Domestic conference

    Atsushi Nakayama, Noriyuki Kogure, Mariko Kitajima, Hiromitsu Takayama

    AIMECS11 (Tokyo, Japan)  2011.11 

  • 五環性Fawcettimine型リコポジウムアルカロイドHuperzine-Qの不斉全合成 Domestic conference

    中山淳, 小暮紀行, 北島満里子, 高山廣光

    第46回天然物化学談話会 (静岡)  2011.07 

  • 五環性Fawcettimine型リコポジウムアルカロイドHuperzine-Qの不斉全合成 Domestic conference

    中山淳, 小暮紀行, 北島満里子, 高山廣光

    第99回有機合成シンポジウム (東京)  2011.06 

  • Pauson-Khand反応を基盤としたFawcettimine型リコポジウムアルカロイド類の不斉全合成研究 Domestic conference

    中山淳, 小暮紀行, 北島満里子, 高山廣光

    第36回反応と合成の進歩シンポジウム (名古屋)  2010.11 

  • Pauson-Khand反応を基盤としたFawcettimine型アルカロイド類の不斉全合成研究 Domestic conference

    中山淳, 小暮紀行, 北島満里子, 高山廣光

    若手研究者のためのセミナー (千葉)  2010.09 

  • First Asymmetric Total Synthese of Fawcettimine-Type Lycopodium Alkaloids, Lycoposerramine-C and Phlegmariurine-A Domestic conference

    Atsushi Nakayama, Noriyuki Kogure, Mariko Kitajima, Hiromitsu Takayama

    The First CU-MU Joint Seminar on Pharmaceutical Research (Bankok, Thailand)  2010.03 

  • Lycopodium serratum由来新規Lycopodiumアルカロイド類の不斉全合成 Domestic conference

    中山淳, 田中智之, 小暮紀行, 北島満里子, 高山廣光

    第51回天然有機化合物討論会 (名古屋)  2009.10 

  • 新規リコポジウムアルカロイドLycoposerramine-Cの不斉全合成研究 Domestic conference

    中山淳, 小暮紀行, 北島満里子, 高山廣光

    日本薬学会第129年会 (京都)  2009.03 

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Industrial Property Rights

  • 新規イノン化合物及びその用途

    中山淳, 寺町順平, 安倍正博, 難波康祐, 伊藤孝司, 辻大輔

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    property_type：Patent 

    Application no：PCT出願:PCT/JP2019/042086 

  • 新規イノン化合物及びその用途

    中山淳, 寺町順平, 安倍正博, 難波康祐, 伊藤孝司, 辻大輔

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    property_type：Patent 

    Application no：特願2018-203219 

  • 蛍光色素を用いた歯周病の簡易検査

    難波康祐, 中山淳, 大谷彬

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    property_type：Patent 

    Application no：特願2015-129848 

    Patent/Registration no：特許WO2017002754 

Grant-in-Aid for Scientific Research

  • 大環状化合物群の網羅的合成から拓く化合物潜在空間

    Grant-in-Aid for Transformative Research Areas  2024.04

  • がん細胞被認識強化をもたらす未知生体内標的分子の同定と創薬基盤の構築

    Grant-in-Aid for Scientific Research(C)  2023

  • 多発性骨髄腫克服を目指した共有結合性官能基含有治療薬の開発研究

    Grant-in-Aid for Scientific Research(C)  2020.04

  • Elucidation of the molecular mechanism of the innovative fertilizer that greens the desert: unknown function search of phytosiderophore

    Grant-in-Aid for Scientific Research(B)  2019.04

  • 骨改善作用を併せ持つ新規多発性骨髄腫治療薬の創製研究

    Grant-in-Aid for Scientific Research(C)  2017.04

  • Molecular design of innovative agrochemicals for greening of infertile soil: chemical biology of mugineic acids

    Grant-in-Aid for Scientific Research(B)  2016.04

  • Development of nobel anti-myeloma agent based on natural macrolide

    Grant-in-Aid for Young Scientists(B)  2015.04

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Other

  • Job Career

    2020.10 - Now

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    Osaka City University Graduate School of Science Lecturer