Updated on 2025/02/17

写真a

 
MATSURA Tomoka
 
Organization
Graduate School of Medicine Department of Basic Medical Science Assistant Professor
School of Medicine Department of Medical Science
Title
Assistant Professor
Affiliation
Institute of Medicine

Position

  • Graduate School of Medicine Department of Basic Medical Science 

    Assistant Professor  2022.04 - Now

  • School of Medicine Department of Medical Science 

    Assistant Professor  2022.04 - Now

Research Areas

  • Life Science / Hygiene and public health (laboratory)  / 新型コロナウイルス、ワクチン、肝疾患、消化器疾患

Research Interests

  • 消化器疾患

  • Pubric Health

  • ワクチン疫学

Professional Memberships

  • 日本疫学会

    2022.10

  • 日本ワクチン学会

    2021.09 - Now

  • 日本消化器内視鏡学会

    2020.06

  • 日本公衆衛生学会

    2018.08

  • 日本肝臓学会

    2016.07

  • 日本消化器病学会

    2011.04 - Now

  • 日本内科学会

    2010.04 - Now

▼display all

Job Career (off-campus)

  • Osaka Metropolitan University   Graduate School of Medicine, Department of Public Health

    2021.04 - Now

Papers

  • Factors impacting antibody kinetics, including fever and vaccination intervals, in SARS-CoV-2-naïve adults receiving the first four mRNA COVID-19 vaccine doses.

    Tomoka Matsuura, Wakaba Fukushima, Yu Nakagama, Yasutoshi Kido, Tetsuo Kase, Kyoko Kondo, Natsuko Kaku, Kazuhiro Matsumoto, Asae Suita, Emiko Mukai, Yuko Nitahara, Ayako Konishi, Ayane Kasamatsu, Sachie Nakagama, Etsuko Nakagami-Yamaguchi, Satoko Ohfuji, Yukihiro Kaneko, Akira Kaneko, Hiroshi Kakeya, Yoshio Hirota

    Scientific reports   14 ( 1 )   7217 - 7217   2024.03

    　More details

    Publishing type：Research paper (scientific journal)   International / domestic magazine：International journal  

    To evaluate the antibody response following the initial four doses of mRNA vaccines (BNT162b2 or mRNA-1273) in SARS-CoV-2-naïve healthy adults and investigate factors influencing antibody titer increases, this prospective cohort study was conducted in Japan from March 2021. The study included participants who received either the 1st and 2nd doses (n = 467), 3rd dose (n = 157), or 4th dose (n = 89). Blood samples were collected before and up to 6 months after each dose, and anti-receptor-binding domain antibody levels were measured. Multivariate analysis (usin multiple linear regression or linear mixed models) revealed several factors significantly associated with higher post-vaccination antibody levels, including mRNA-1273 vaccine (after the 1st and 2nd dose), male gender (after the 3rd and 4th doses), younger age (after the 1st and 2nd dose), non-smoking status (after the 2nd dose), non-use of immunosuppressive agents (after the 1st dose), higher pre-vaccination antibody titers (after the 2nd, 3rd, and 4th doses), and higher post-vaccination fever (after the 2nd and 4th doses). Furthermore, longer intervals since the last dose were significantly associated with higher antibody levels after the 3rd and 4th doses. These findings provide valuable insights for optimizing vaccination strategies.

    DOI： 10.1038/s41598-024-57931-0

    PubMed

Presentations

▼display all

Grant-in-Aid for Scientific Research

  • Analytic epidemiology on prognosis of Budd-Chiari syndrome

    Grant-in-Aid for Scientific Research(C)  2025

  • Factors related to antibody response to COVID-19 vaccines: an epidemiological study focusing on metabolomics

    Grant-in-Aid for Scientific Research(B)  2024

  • Analytic epidemiology on prognosis of Budd-Chiari syndrome

    Grant-in-Aid for Scientific Research(C)  2024

Charge of off-campus class subject

  • Pubric Health

    2022.04
    -
    Now
    Institution：Osaka Metropolitan University Graduate School of Medicine