Updated on 2023/06/23

写真a

 
OMINAMI Masaki
 
Organization
Graduate School of Medicine Department of Clinical Medical Science Lecturer
School of Medicine Department of Medical Science
Title
Lecturer
Affiliation
Institute of Medicine

Position

  • Graduate School of Medicine Department of Clinical Medical Science 

    Lecturer  2022.04 - Now

  • School of Medicine Department of Medical Science 

    Lecturer  2022.04 - Now

Research Areas

  • Life Science / Gastroenterology

Research Interests

  • 消化器内視鏡

  • 消化器内科学

Professional Memberships

  • 日本消化管学会

  • JAPANESE SOCIETY OF GASTROENTEROLOGY

  • JAPAN GASTROENTEROLOGICAL ENDOSCOPY SOCIETY

  • THE JAPANESE SOCIETY OF INTERNAL MEDICINE

Job Career (off-campus)

  • 大阪市立大学大学院医学研究科 消化器内科学   病院講師

    2018.04 - Now

Papers

  • Successful treatment using balloon-assisted enteroscopy for jejunal loop variceal bleeding after pancreaticoduodenectomy.

    Maeda N, Maruyama H, Higashimori A, Ominami M, Fukunaga S, Nagami Y, Fujiwara Y

    Endoscopy   55 ( S 01 )   E536 - E537   2023.12（ ISSN:0013-726X ）

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  • Prevalence of elderly eosinophilic esophagitis and their clinical characteristics.

    Fujiwara Y, Kanamori A, Sawada A, Ominami M, Fukunaga S, Otani K, Hosomi S, Nagami Y, Taira K, Tanaka F

    Scandinavian journal of gastroenterology   1 - 6   2023.06（ ISSN:0036-5521 ）

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  • Responses of Proton Pump Inhibitors and Potassium-Competitive Acid Blockers According to Outcomes of Symptom, Endoscopy, and Histology in Patients With Eosinophilic Esophagitis.

    Fujiwara Y, Sawada A, Ominami M, Fukunaga S, Otani K, Hosomi S, Nagami Y, Taira K, Tanaka F

    Journal of clinical gastroenterology   2023.06（ ISSN:0192-0790 ）

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  • Pretreatment serum monocyte chemoattractant protein-1 as a predictor of long-term outcome by ustekinumab in patients with Crohn's disease.

    Okuda H, Hosomi S, Itani S, Kurimoto N, Kobayashi Y, Nakata R, Nishida Y, Ominami M, Nadatani Y, Fukunaga S, Otani K, Kamata N, Tanaka F, Nagami Y, Taira K, Ohfuji S, Fujiwara Y

    Journal of gastroenterology and hepatology   38 ( 6 )   910 - 920   2023.06（ ISSN:0815-9319 ）

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  • Risk factors for adverse events associated with endoscopic submucosal dissection for superficial pharyngeal cancer.

    Ominami M, Nagami Y, Kono M, Yamamoto Y, Yokota C, Teranishi Y, Oishi M, Manabe T, Ochiai T, Tanoue K, Yamamura M, Maruyama H, Nadatani Y, Fukunaga S, Otani K, Hosomi S, Tanaka F, Kamata N, Taira K, Sunami K, Fujiwara Y

    Surgical endoscopy   2023.05（ ISSN:0930-2794 ）

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  • Upper gastrointestinal endoscopic findings in functional constipation and irritable bowel syndrome diagnosed using the Rome IV criteria: a cross-sectional survey during a medical check-up in Japan.

    Otani K, Watanabe T, Takahashi K, Nadatani Y, Ominami M, Fukunaga S, Hosomi S, Kamata N, Tanaka F, Nagami Y, Taira K, Kimura T, Fukumoto S, Fujiwara Y

    BMC gastroenterology   23 ( 1 )   140   2023.05

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  • Esophageal mast cells may be associated with the perception of symptoms in patients with eosinophilic esophagitis(タイトル和訳中)

    Kanamori Atsushi, Tanaka Fumio, Takashima Shingo, Sawada Akinari, Ominami Masaki, Nadatani Yuji, Fukunaga Shusei, Otani Koji, Hosomi Shuhei, Kamata Noriko, Nagami Yasuaki, Taira Koichi, Watanabe Toshio, Fujiwara Yasuhiro

    Esophagus   20 ( 2 )   333 - 341   2023.04（ ISSN:1612-9059 ）

  • Impact of peroral endoscopic myotomy on high-resolution manometry findings and their association with the procedure's outcomes.

    Yoshitaka Hata, Hiroki Sato, Yuto Shimamura, Hirofumi Abe, Akio Shiwaku, Junya Shiota, Chiaki Sato, Masaki Ominami, Hisashi Fukuda, Ryo Ogawa, Jun Nakamura, Tetsuya Tatsuta, Yuichiro Ikebuchi, Hiroshi Yokomichi, Eikichi Ihara, Haruhiro Inoue

    Gastrointestinal endoscopy   97 ( 4 )   673 - 683.e2   2023.04（ ISSN:0016-5107 ）

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    Publishing type：Research paper (scientific journal)   International / domestic magazine：International journal  

    BACKGROUND & AIMS: Peroral endoscopic myotomy (POEM) is conducted for patients with esophageal motility disorders based on high-resolution manometry (HRM) findings. However, the impact of POEM on HRM findings and the associations between post-POEM HRM and outcomes have not been clarified. METHODS: In a multicenter, observational cohort study, patients with achalasia treated by POEM received follow-up HRM. Associations between patient characteristics, POEM procedures, and post-POEM HRM findings, including integrated relaxation pressure (IRP) and distal contractile integral (DCI), were investigated. Furthermore, the outcomes of the POEM procedure were compared with the post-POEM HRM findings. RESULTS: Of 2,171 patients, 151 (7.0%) showed residual high post-POEM IRP (≥26 mmHg, Starlet). In a multivariate analysis, high pre-POEM IRPs (odds ratio [OR]=24.3) and gastric myotomy >2 cm (OR=0.22) were found to be positive and negative predictive factors of high post-POEM IRPs, respectively. Peristalsis recovery (DCI ≥500 mmHg-cm-sec, at least one swallow, Starlet) was visible in 121 (19.6%) of 618 patients, and they were type II-III achalasia. High pre-POEM IRP (OR=2.65) and DCI ≥500 (OR=2.98) predicted peristalsis recovery, while esophageal dilation (OR=0.42) predicted a risk of no recovery. Extended myotomy did not reveal a significant impact on peristalsis recovery. High or low post-POEM IRP and DCI did not increase the incidence of clinical failure, reflux esophagitis, or symptomatic gastroesophageal reflux disease. CONCLUSIONS: Extended gastric myotomy decreased IRP values, while peristalsis recovery depended on the characteristics of achalasia. A residual high post-POEM IRP does not necessarily mean clinical failure. Routine HRM follow-up is not recommended after POEM.

    DOI： 10.1016/j.gie.2022.10.039

    PubMed

  • Esophageal mast cells may be associated with the perception of symptoms in patients with eosinophilic esophagitis.

    Kanamori A, Tanaka F, Takashima S, Sawada A, Ominami M, Nadatani Y, Fukunaga S, Otani K, Hosomi S, Kamata N, Nagami Y, Taira K, Watanabe T, Fujiwara Y

    Esophagus : official journal of the Japan Esophageal Society   20 ( 2 )   333 - 341   2023.04（ ISSN:1612-9059 ）

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  • Risk scoring system for the preprocedural prediction of the clinical failure of peroral endoscopic myotomy: a multicenter case-control study.

    Hirofumi Abe, Shinwa Tanaka, Hiroki Sato, Yuto Shimamura, Hiroki Okada, Junya Shiota, Chiaki Sato, Hiroyuki Sakae, Masaki Ominami, Yoshitaka Hata, Hisashi Fukuda, Ryo Ogawa, Jun Nakamura, Tetsuya Tatsuta, Yuichiro Ikebuchi, Hiroshi Yokomichi, Haruhiro Inoue

    Endoscopy   55 ( 3 )   217 - 224   2023.03（ ISSN:0013-726X ）

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    Publishing type：Research paper (scientific journal)   International / domestic magazine：International journal  

    BACKGROUND:  Peroral endoscopic myotomy (POEM) is effective for the management of achalasia and its variants; however, it can be ineffective in some patients. We aimed to develop and validate a risk scoring system to predict the clinical failure of POEM preoperatively. METHODS:  Consecutive patients who underwent POEM in 14 high volume centers between 2010 and 2020 were enrolled in this study. Clinical failure was defined as an Eckardt score of ≥ 4 or retreatment. A risk scoring system to predict the short-term clinical failure of POEM was developed using multivariable logistic regression and internally validated using bootstrapping and decision curve analysis. RESULTS:  Of the 2740 study patients, 112 (4.1 %) experienced clinical failure 6 months after POEM. Risk scores were assigned for three preoperative factors as follows: preoperative Eckardt score (1 point), manometric diagnosis (-4 points for type II achalasia), and a history of prior treatments (1 point for pneumatic dilation or 12 points for surgical/endoscopic myotomy). The discriminative capacity (concordance statistics 0.68, 95 %CI 0.62-0.72) and calibration (slope 1.15, 95 %CI 0.87-1.40) were shown. Decision curve analysis demonstrated its clinical usefulness. Patients were categorized into low (0-8 points; estimated risk of clinical failure < 5 %) and high risk (9-22 points; ≥ 5 %) groups. The proportions of clinical failure for the categories were stratified according to the mid-term outcomes (log-rank test, P < 0.001). CONCLUSIONS:  This risk scoring system can predict the clinical failure of POEM preoperatively and provide useful information when making treatment decisions.

    DOI： 10.1055/a-1876-7554

    PubMed

  • Neutrophil-to-lymphocyte ratio may predict clinical relapse in ulcerative colitis patients with mucosal healing.

    Kurimoto N, Nishida Y, Hosomi S, Itani S, Kobayashi Y, Nakata R, Ominami M, Nadatani Y, Fukunaga S, Otani K, Tanaka F, Nagami Y, Taira K, Kamata N, Fujiwara Y

    PloS one   18 ( 1 )   e0280252   2023

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  • Long-term rebleeding rate and predictive factors of rebleeding after capsule endoscopy in patients with obscure GI bleeding

    Koji Otani, Sunao Shimada, Toshio Watanabe, Yuji Nadatani, Akira Higashimori, Masaki Ominami, Shusei Fukunaga, Shuhei Hosomi, Noriko Kamata, Fumio Tanaka, Yasuaki Nagami, Koichi Taira, Yasuhiro Fujiwara

    Gastrointestinal Endoscopy   96 ( 6 )   956 - 969.e3   2022.12（ ISSN:0016-5107 ）

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.gie.2022.07.012

    PubMed

  • An extra 1-cm margin during endoscopic submucosal dissection can control subsquamous tumor extension of esophagogastric junction adenocarcinoma.

    Manabe T, Nagami Y, Tanoue K, Sakai T, Maruyama H, Ominami M, Fukunaga S, Otani K, Hosomi S, Tanaka F, Taira K, Watanabe T, Fujiawaral Y

    Endoscopy international open   10 ( 11 )   E1501 - E1507   2022.11（ ISSN:2364-3722 ）

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  • Gel improves visibility despite post-prandial timing of endoscopy for accidental ingestion.

    Ochiai T, Ominami M, Nagami Y, Manabe T, Kono M, Fukunaga S, Fujiwara Y

    Endoscopy   54 ( 11 )   E660 - E661   2022.11（ ISSN:0013-726X ）

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  • EUS-FNB針でslow pull法を行い最終診断し得た腎癌膵転移の一例

    宮部 渉平, 田上 光治郎, 黒川 達哉, 島本 宜紀, 垣谷 有紀, 山村 匡史, 東森 啓, 丸山 紘嗣, 大南 雅揮, 灘谷 祐二, 福永 周生, 大谷 恒史, 細見 周平, 鎌田 紀子, 田中 史生, 永見 康明, 平良 高一, 藤原 靖弘

    日本消化器内視鏡学会近畿支部例会プログラム・抄録集   109回   95 - 95   2022.11

  • Efficacy of peroral endoscopic myotomy for esophageal motility disorders after gastric surgery: Japan Achalasia Multicenter Study.

    Nakamura J, Sato H, Onimaru M, Abe H, Shiwaku H, Shiota J, Sato C, Sakae H, Ominami M, Hata Y, Fukuda H, Ogawa R, Tatsuta T, Ikebuchi Y, Yokomichi H, Takuto H, Inoue H

    Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society   34 ( 7 )   1394 - 1402   2022.11（ ISSN:0915-5635 ）

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  • Efficacy of peroral endoscopic myotomy for esophageal motility disorders after gastric surgery: Japan Achalasia Multicenter Study(タイトル和訳中)

    Nakamura Jun, Sato Hiroki, Onimaru Manabu, Abe Hirofumi, Shiwaku Hironari, Shiota Junya, Sato Chiaki, Sakae Hiroyuki, Ominami Masaki, Hata Yoshitaka, Fukuda Hisashi, Ogawa Ryo, Tatsuta Tetsuya, Ikebuchi Yuichiro, Yokomichi Hiroshi, Hikichi Takuto, Inoue Haruhiro

    Digestive Endoscopy   34 ( 7 )   1394 - 1402   2022.11（ ISSN:0915-5635 ）

  • Subtype of Achalasia and Integrated Relaxation Pressure Measured Using the Starlet High-resolution Manometry System: A Multicenter Study in Japan.

    Tatsuta T, Sato H, Fujiyoshi Y, Abe H, Shiwaku A, Shiota J, Sato C, Ominami M, Hata Y, Fukuda H, Ogawa R, Nakamura J, Ikebuchi Y, Yokomichi H, Fukuda S, Inoue H

    Journal of neurogastroenterology and motility   28 ( 4 )   562 - 571   2022.10（ ISSN:2093-0879 ）

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  • 超音波内視鏡下肝胃瘻孔形成術におけるプラスチックステントの治療成績

    山村 匡史, 丸山 紘嗣, 島本 宜紀, 前田 夏美, 河野 光泰, 眞鍋 琢, 落合 正, 垣谷 有紀, 田上 光治郎, 東森 啓, 大南 雅揮, 灘谷 裕二, 福永 周生, 大谷 恒史, 細見 周平, 鎌田 紀子, 田中 史生, 永見 康明, 平良 高一, 藤原 靖弘

    Gastroenterological Endoscopy   64 ( Suppl.2 )   2119 - 2119   2022.10（ ISSN:0387-1207 ）

  • 膵小型腫瘤性病変に対する内視鏡診断の有用性および安全性に関する検討

    垣谷 有紀, 丸山 紘嗣, 島本 宣紀, 山村 匡史, 田上 光治郎, 東森 啓, 大南 雅揮, 灘谷 裕二, 福永 周生, 大谷 恒史, 細見 周平, 鎌田 紀子, 田中 史生, 永見 康明, 平良 高一, 藤原 靖弘

    Gastroenterological Endoscopy   64 ( Suppl.2 )   2123 - 2123   2022.10（ ISSN:0387-1207 ）

  • 胃切除Roux-en-Y再建症例における総胆管結石に対するバルーン内視鏡下結石治療の成績と截石困難の危険因子の検討

    田上 光治郎, 丸山 紘嗣, 島本 宣紀, 前田 夏美, 眞鍋 琢, 河野 光泰, 落合 正, 垣谷 有紀, 山村 匡史, 東森 啓, 大南 雅揮, 福永 周生, 灘谷 祐二, 大谷 恒史, 細見 周平, 鎌田 紀子, 永見 康明, 田中 史生, 平良 高一, 藤原 靖弘

    Gastroenterological Endoscopy   64 ( Suppl.2 )   2089 - 2089   2022.10（ ISSN:0387-1207 ）

  • 当科で経験した膵腫瘍に対するEUS-FNAB後に膿瘍を形成した4例

    島本 宜紀, 丸山 紘嗣, 垣谷 有紀, 山村 匡史, 田上 光治郎, 東森 啓, 大南 雅揮, 灘谷 祐二, 福永 周生, 大谷 恒史, 細見 周平, 田中 史生, 永見 康明, 平良 高一, 藤原 靖弘

    Gastroenterological Endoscopy   64 ( Suppl.2 )   2127 - 2127   2022.10（ ISSN:0387-1207 ）

  • 実臨床における好酸球性食道炎治療の現状

    藤原 靖弘, 田中 史生, 中田 理恵子, 垣谷 有紀, 山村 匡史, 田上 光治郎, 沢田 明也, 東森 啓, 西田 裕, 丸山 紘嗣, 大南 雅揮, 灘谷 祐二, 福永 周生, 大谷 恒史, 細見 周平, 鎌田 紀子, 永見 康明, 平良 高一

    日本消化器病学会雑誌   119 ( 10 )   929 - 936   2022.10（ ISSN:0446-6586 ）

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    当科における好酸球性食道炎306例の治療について検討した.286例(93.5%)で一次治療としてプロトンポンプ阻害薬またはカリウム競合型アシッドブロッカーが選択されていた.55例(18.0%)にステロイド嚥下療法が施行されていた.平均観察期間17.7ヵ月において,無投薬経過観察は46.4%,酸分泌抑制薬による維持療法またはオンデマンド療法は37.3%,ステロイド嚥下維持療法は9.8%であった.ほとんどの症例は胃食道逆流症に準じた治療戦略がとられており,良好な臨床経過が得られていたが,一部の症例は難治例と考えられた.本邦における実臨床での好酸球性食道炎治療の現状が明らかとなった.(著者抄録)

    Other URL： https://search-tp.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2022&ichushi_jid=J01118&link_issn=&doc_id=20221018300007&doc_link_id=1390575185895536768&url=https%3A%2F%2Fcir.nii.ac.jp%2Fcrid%2F1390575185895536768&type=CiNii&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00003_2.gif

  • 実臨床における好酸球性食道炎治療の現状

    藤原 靖弘, 田中 史生, 中田 理恵子, 垣谷 有紀, 山村 匡史, 田上 光治郎, 沢田 明也, 東森 啓, 西田 裕, 丸山 紘嗣, 大南 雅揮, 灘谷 祐二, 福永 周生, 大谷 恒史, 細見 周平, 鎌田 紀子, 永見 康明, 平良 高一

    日本消化器病学会雑誌   119 ( 10 )   929 - 936   2022.10（ ISSN:0446-6586 ）

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    当科における好酸球性食道炎306例の治療について検討した.286例(93.5%)で一次治療としてプロトンポンプ阻害薬またはカリウム競合型アシッドブロッカーが選択されていた.55例(18.0%)にステロイド嚥下療法が施行されていた.平均観察期間17.7ヵ月において,無投薬経過観察は46.4%,酸分泌抑制薬による維持療法またはオンデマンド療法は37.3%,ステロイド嚥下維持療法は9.8%であった.ほとんどの症例は胃食道逆流症に準じた治療戦略がとられており,良好な臨床経過が得られていたが,一部の症例は難治例と考えられた.本邦における実臨床での好酸球性食道炎治療の現状が明らかとなった.(著者抄録)

  • Risks of refractory chest pain after peroral endoscopic myotomy in achalasia-related esophageal motility disorders: short-term results from a multicenter study in Japan.

    Hisashi Fukuda, Hiroki Sato, Yusuke Fujiyoshi, Hirofumi Abe, Hiroki Okada, Junya Shiota, Chiaki Sato, Hiroyuki Sakae, Masaki Ominami, Yoshitaka Hata, Ryo Ogawa, Jun Nakamura, Tetsuya Tatsuta, Yuichiro Ikebuchi, Hiroshi Yokomichi, Hironori Yamamoto, Haruhiro Inoue

    Gastrointestinal endoscopy   96 ( 4 )   620 - 629.e4   2022.10（ ISSN:0016-5107 ）

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    Publishing type：Research paper (scientific journal)   International / domestic magazine：International journal  

    BACKGROUND AND AIMS: The etiology of chest pain in achalasia-related esophageal motility disorders (AEMDs) and the frequency and risk factors of persistent chest pain after peroral endoscopic myotomy (POEM) remain unclear. METHODS: A multicenter cohort study including 14 hospitals was conducted to elucidate the characteristics of patients with chest pain and the efficacy of POEM. RESULTS: Consecutive cases of AEMDs included 2,294 (64.2%) and 1,280 (35.8%) patients with and without chest pain, respectively. Among the 2,107 patients with chest pain who underwent POEM, we observed complete remission in 1,464 patients (69.5%) and non-remission in 643 patients (30.5%) including partial response in 619 patients (29.4%) and resistance in 24 patients (1.1%). Multivariate analysis revealed that advanced age (odds ratio [OR]:0.28), male sex (OR:0.70), prior treatment (OR:1.39), and sigmoid type (OR:0.65) were related to the prevalence of chest pain. Long disease duration (OR:0.69) and esophageal dilation (OR:0.79) were related with decreased severity. POEM improved patients' quality of life that was hindered by chest pain. Early onset (OR:1.45), advanced age (OR:0.58), male sex (OR:0.79), prior treatment (OR:1.37), and posterior myotomy (OR:1.42) were associated with non-remission after POEM; high-resolution manometry (HRM) findings and myotomy length showed no statistical significance on pain etiology and persistence after POEM. CONCLUSIONS: The prevalence and severity of chest pain were dependent on age, sex, disease duration, prior treatment, and esophageal morphology, rather than HRM findings. The efficacy of POEM is satisfactory; however, residual pain was often observed. Excessively long myotomy can be avoided, and anterior myotomy may be recommended.

    DOI： 10.1016/j.gie.2022.04.1347

    PubMed

  • Correction: Risk factors and long-term course of gastroesophageal reflux disease after peroral endoscopic myotomy: A large-scale multicenter cohort study in Japan.

    Shiwaku H, Sato H, Shimamura Y, Abe H, Shiota J, Sato C, Ominami M, Sakae H, Hata Y, Fukuda H, Ogawa R, Nakamura J, Tatsuta T, Ikebuchi Y, Yokomichi H, Hasegawa S, Inoue H

    Endoscopy   54 ( 9 )   C13   2022.09（ ISSN:0013-726X ）

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  • Successful treatment using a side-viewing duodenoscope for esophagojejunal varices on the jejunal side of the anastomosis site after total gastrectomy.

    Hirotsugu Maruyama, Akira Higashimori, Natsumi Maeda, Masaki Ominami, Shusei Fukunaga, Yasuaki Nagami, Yasuhiro Fujiwara

    Endoscopy   54 ( 9 )   E484 - E485   2022.09（ ISSN:0013-726X ）

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    Publishing type：Research paper (scientific journal)   International / domestic magazine：International journal  

    DOI： 10.1055/a-1625-5369

    PubMed

  • Risk factors and long-term course of gastroesophageal reflux disease after peroral endoscopic myotomy: A large-scale multicenter cohort study in Japan.

    Hironari Shiwaku, Hiroki Sato, Yuto Shimamura, Hirofumi Abe, Junya Shiota, Chiaki Sato, Masaki Ominami, Hiroyuki Sakae, Yoshitaka Hata, Hisashi Fukuda, Ryo Ogawa, Jun Nakamura, Tetsuya Tatsuta, Yuichiro Ikebuchi, Hiroshi Yokomichi, Suguru Hasegawa, Haruhiro Inoue

    Endoscopy   54 ( 9 )   839 - 847   2022.09（ ISSN:0013-726X ）

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    Publishing type：Research paper (scientific journal)   International / domestic magazine：International journal  

    BACKGROUND : Gastroesophageal reflux disease (GERD) and reflux esophagitis remain problems after peroral endoscopic myotomy (POEM). This study aimed to elucidate the risk factors and long-term course of reflux esophagitis and symptomatic GERD after POEM. METHODS : This multicenter cohort study involved 14 high volume centers. Overall, 2905 patients with achalasia-related esophageal motility disorders treated with POEM were analyzed for reflux esophagitis, severe reflux esophagitis (Los Angeles classification C or D), and symptomatic GERD. RESULTS : Reflux esophagitis was diagnosed in 1886 patients (64.9 %). Age ≥ 65 years (risk ratio [RR] 0.85), male sex (RR 1.11), posterior myotomy (RR 1.12), esophageal myotomy > 10 cm (RR 1.12), and gastric myotomy > 2 cm (RR 1.17) were independently associated with reflux esophagitis. Severe reflux esophagitis was diagnosed in 219 patients (7.5 %). Age ≥ 65 years (RR 1.72), previous treatments (RR 2.21), Eckardt score ≥ 7 (RR 0.68), sigmoid-type achalasia (RR 1.40), and esophageal myotomy > 10 cm (RR 1.59) were factors associated with severe reflux esophagitis. Proton pump inhibitors (PPIs) were more effective for reflux esophagitis at 5-year follow-up (P = 0.03) than after 1 year (P = 0.08). Symptomatic GERD was present in 458 patients (15.9 %). Symptom duration ≥ 10 years (RR 1.28), achalasia diagnosis (RR 0.68), integrated relaxation pressure ≥ 26 (RR 0.60), and posterior myotomy (RR 0.80) were associated with symptomatic GERD. The incidence of symptomatic GERD was lower at 5-year follow-up compared with that after 1 year (P = 0.04), particularly in PPI users (P < 0.001). CONCLUSIONS : The incidence of severe reflux esophagitis was low after POEM, but excessive myotomy for older patients with previous treatments should be avoided. Early phase symptomatic GERD is non-acid reflux dependent and the natural course is favorable, basically supporting conservative treatment.

    DOI： 10.1055/a-1753-9801

    PubMed

  • Psychological Stress Exacerbates Inflammation of the Ileum via the Corticotropin-Releasing Hormone-Mast Cell Axis in a Mouse Model of Eosinophilic Enteritis

    Atsushi Kanamori, Fumio Tanaka, Masaki Ominami, Yuji Nadatani, Shusei Fukunaga, Koji Otani, Shuhei Hosomi, Noriko Kamata, Yasuaki Nagami, Koichi Taira, Yasuhiro Fujiwara

    International Journal of Molecular Sciences   23 ( 15 )   8538 - 8538   2022.08（ ISSN:16616596 ）

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    Publishing type：Research paper (scientific journal)  

    The effects of psychological stress on eosinophilic gastrointestinal disorders have not been elucidated. This study investigated the effects of psychological stress in a mouse model of eosinophilic enteritis (EoN). BALB/c mice were treated with ovalbumin (OVA) to create an EoN model and subjected to either water avoidance stress (WAS) or sham stress (SS). Microscopic inflammation, eosinophil and mast cell counts, mRNA expression, and protein levels of type 2 helper T cell (Th2) cytokines in the ileum were compared between groups. We evaluated ex vivo intestinal permeability using an Ussing chamber. A corticotropin-releasing hormone type 1 receptor (CRH-R1) antagonist was administered before WAS, and its effects were analyzed. WAS significantly increased diarrhea occurrence and, eosinophil and mast cell counts, and decreased the villus/crypt ratio compared to those in the SS group. The mRNA expression of CRH, interleukin IL-4, IL-5, IL-13, eotaxin-1, and mast cell tryptase β2 significantly increased, and the protein levels of IL-5, IL-13, and OVA-specific immunoglobulin E (IgE) also significantly increased in the WAS group. Moreover, WAS significantly increased the intestinal permeability. The CRH-R1 antagonist significantly inhibited all changes induced by WAS. Psychological stress exacerbated ileal inflammation via the CRH-mast cell axis in an EoN mouse model.

    DOI： 10.3390/ijms23158538

    PubMed

  • 膵頭十二指腸門脈合併切除後に発生した挙上空腸静脈瘤出血に対してダブルバルーン小腸内視鏡下静脈瘤硬化療法で止血を得た一例

    前田 夏美, 丸山 紘嗣, 垣谷 有紀, 田上 光治郎, 山村 匡史, 東森 啓, 大南 雅揮, 福永 周生, 細見 周平, 永見 康明, 平良 高一, 影山 健, 山本 晃, 藤原 靖弘

    日本門脈圧亢進症学会雑誌   28 ( 3 )   116 - 116   2022.08（ ISSN:1344-8447 ）

  • 内視鏡的粘膜下層剥離術および経口的内視鏡的筋層切開術により治療した、アカラシア症例に認められた食道癌　日本アカラシア多施設共同研究(Esophageal carcinoma in achalasia patients managed with endoscopic submucosal dissection and peroral endoscopic myotomy: Japan Achalasia Multicenter Study)

    Sato Hiroki, Nishikawa Yohei, Abe Hirofumi, Shiwaku Hironari, Shiota Junya, Sato Chiaki, Sakae Hiroyuki, Ominami Masaki, Hata Yoshitaka, Fukuda Hisashi, Ogawa Ryo, Nakamura Jun, Tatsuta Tetsuya, Ikebuchi Yuichiro, Yokomichi Hiroshi, Terai Shuji, Inoue Haruhiro

    Digestive Endoscopy   34 ( 5 )   965 - 973   2022.07（ ISSN:0915-5635 ）

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    アカラシアを合併した食道癌(EC)に対する経口的内視鏡的筋層切開術(POEM)の意義と内視鏡的粘膜下層剥離術(ESD)の適応を明らかにするため、14施設の共同コホート研究を行った。検討対象は、アカラシア関連食道運動障害性疾患(EMD)を有する3707例であった。ECの発生リスク、ECの特徴およびPOEM/ESDの臨床成績に関して調査した。POEMを施行した症例に対する1年間のサーベイランス内視鏡検査で、新規ECの72.1%が診断された。診断された62症例123病変中40.3%で、37.5ヵ月の間に複数ないし異時性の病変が認められた。ECの存在部位は胸部中部食道が多く(58.5%)、また後壁に多かった(73.2%)。POEMはEC合併例においても比較的安全かつ有効に施行され、ESD後の症例においても同様であった。POEM前の症例で95.8%、POEM後の症例で89.3%に内視鏡的一括切除が行われた(P=0.351)。POEM切開線上のESDは線維化により困難であった。多変量解析の結果、常習的飲酒、喫煙歴、高齢、長期に亘る罹患がECの危険因子であることが示された。アルコール摂取と喫煙はEC発癌に対し相乗効果を呈した。アカラシアに対するPOEM施行後のサーベイランス内視鏡は、特に危険因子を有する症例においてEC発見に有用であることが示された。

  • Evaluation of long-term survival in patients with severe comorbidities after endoscopic submucosal dissection for esophageal squamous cell carcinoma.

    Hirano S, Nagami Y, Yamamura M, Tanoue K, Sakai T, Maruyama H, Ominami M, Nadatani Y, Fukunaga S, Otani K, Hosomi S, Tanaka F, Kamata N, Taira K, Shiba M, Watanabe T, Fujiwara Y

    Surgical endoscopy   36 ( 7 )   5011 - 5022   2022.07（ ISSN:0930-2794 ）

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  • Esophageal carcinoma in achalasia patients managed with endoscopic submucosal dissection and peroral endoscopic myotomy: Japan Achalasia Multicenter Study.

    Sato H, Nishikawa Y, Abe H, Shiwaku H, Shiota J, Sato C, Sakae H, Ominami M, Hata Y, Fukuda H, Ogawa R, Nakamura J, Tatsuta T, Ikebuchi Y, Yokomichi H, Terai S, Inoue H

    Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society   34 ( 5 )   965 - 973   2022.07（ ISSN:0915-5635 ）

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  • Lustrous White Erosions Surrounded by an Erythematous Mucosa: A Novel Endoscopic Finding of Gastric Lesions in Patients with Wilson Disease

    Kitagawa Daiki, Ominami Masaki, Taira Koichi, Tanoue Kojiro, Higashimori Akira, Maruyama Hirotsugu, Itani Shigehiro, Nishida Yu, Nadatani Yuji, Fukunaga Shusei, Otani Koji, Hosomi Shuhei, Tanaka Fumio, Nagami Yasuaki, Kamata Noriko, Kuwae Yuko, Watanabe Toshio, Ohsawa Masahiko, Fujiwara Yasuhiro, on behalf of F-study Group

    Internal Medicine   61 ( 12 )   1835 - 1841   2022.06（ ISSN:0918-2918 ）

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    Publishing type：Research paper (scientific journal)   International / domestic magazine：Domestic journal  

    <p>Wilson disease is an inherited copper metabolism disorder. We herein report a novel endoscopic finding in three men with Wilson disease. These patients underwent upper endoscopy due to gastrointestinal symptoms or during follow-up. In each case, endoscopy revealed lustrous white erosions surrounded by an erythematous mucosa in the greater curvature of the gastric body. A biopsy of the lesions showed orcein-positive tissue, indicating copper deposition, in the interstitial stroma and fundic glands of the mucosa. All patients had been receiving treatment with zinc acetate. These endoscopic findings might have been related to the cytotoxicity of the accumulated copper and zinc acetate. </p>

    DOI： 10.2169/internalmedicine.8076-21

    PubMed

    CiNii Article

  • 除菌療法が奏功せずESDで一括切除したHelicobacter pylori陰性直腸MALTリンパ腫の一例

    金澤 里映, 眞鍋 琢, 山村 匡史, 永見 康明, 島本 宜紀, 前田 夏美, 河野 光泰, 垣谷 有紀, 落合 正, 田上 光治郎, 丸山 紘嗣, 大南 雅揮, 福永 周生, 大谷 恒史, 細見 周平, 鎌田 紀子, 田中 史生, 平良 高一, 藤原 靖弘

    日本消化器内視鏡学会近畿支部例会プログラム・抄録集   108回   89 - 89   2022.06

  • 膵頭十二指腸、門脈合併切除再建後に生じた挙上空腸静脈瘤に対しダブルバルーン小腸内視鏡併用下静脈瘤硬化療法で止血し得た一例

    小西 勝也, 落合 正, 丸山 紘嗣, 前田 夏美, 垣谷 有紀, 田上 光治郎, 山村 匡史, 大南 雅揮, 福永 周生, 灘谷 祐二, 大谷 恒史, 細見 周平, 鎌田 紀子, 田中 史生, 永見 康明, 平良 高一, 影山 健, 城後 篤志, 山本 晃, 藤原 靖弘

    日本消化器内視鏡学会近畿支部例会プログラム・抄録集   108回   84 - 84   2022.06

  • 経口胆道鏡が術前の範囲診断に有用であった胆管内乳頭状腫瘍の1例

    榎本 秀治, 島本 宜紀, 東森 啓, 丸山 紘嗣, 垣谷 有紀, 山村 匡史, 田上 光治郎, 大南 雅揮, 福永 周生, 大谷 恒史, 細見 周平, 田中 史生, 永見 康明, 平良 高一, 田内 潤, 大平 豪, 久保 正二, 藤原 靖弘

    日本消化器内視鏡学会近畿支部例会プログラム・抄録集   108回   84 - 84   2022.06

  • 紅斑性粘膜に取り囲まれた光沢のある白色びらん　Wilson病患者における胃病変の新規内視鏡所見(Lustrous White Erosions Surrounded by an Erythematous Mucosa: A Novel Endoscopic Finding of Gastric Lesions in Patients with Wilson Disease)

    Kitagawa Daiki, Ominami Masaki, Taira Koichi, Tanoue Kojiro, Higashimori Akira, Maruyama Hirotsugu, Itani Shigehiro, Nishida Yu, Nadatani Yuji, Fukunaga Shusei, Otani Koji, Hosomi Shuhei, Tanaka Fumio, Nagami Yasuaki, Kamata Noriko, Kuwae Yuko, Watanabe Toshio, Ohsawa Masahiko, Fujiwara Yasuhiro

    Internal Medicine   61 ( 12 )   1835 - 1841   2022.06（ ISSN:0918-2918 ）

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    症例1は20歳男性で、18歳時にWilson病と診断されていた。心窩部痛を認め、汎血球減少症、肝胆汁酵素の軽度上昇、セルロプラスミンと銅の血清レベル低値、尿中銅排泄量増加が判明した。内視鏡検査では、胃に紅斑に囲まれた白色びらんが認められた。8週のエソメプラゾール治療により、心窩部痛と白色びらんが改善した。症例2は27歳男性で、5歳時にWilson病と診断されていた。心窩部痛、悪心、嘔吐を認め、肝胆汁酵素の軽度上昇、セルロプラスミンと銅の血清レベル低値、尿中銅排泄量増加が判明した。内視鏡検査では、胃に紅斑性粘膜に囲まれた線形白色ビランが認められた。エソメプラゾール治療を開始後、症状が改善した。症例3は42歳男性で、30歳時にWilson病と診断されていた。上腹部症状はなかったが、汎血球減少症、肝胆汁酵素の軽度上昇、プロトロンビン活性低下、セルロプラスミンと銅の血清レベル低下、尿中銅排泄量増加が判明した。内視鏡検査では、胃の紅斑性粘膜上に斑状の白色びらんが認められた。3症例ともに、病変の生検ではオルセイン陽性組織が認められ、銅沈着が示唆された。

  • 潰瘍性大腸炎症例に認められた、抗結核薬投与中の奇異性反応の一例(A case of paradoxical response during anti-tuberculosis treatment in a patient with ulcerative colitis)

    Hosomi Shuhei, Sugita Naoko, Kanamori Atsushi, Ominami Masaki, Otani Koji, Kamata Noriko, Tanaka Fumio, Nagami Yasuaki, Taira Koichi, Fujiwara Yasuhiro

    Clinical Journal of Gastroenterology   15 ( 3 )   592 - 597   2022.06（ ISSN:1865-7257 ）

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    症例は71歳女性で、ステロイド依存性潰瘍性大腸炎(UC)に罹患していたが、内視鏡的に高度活動性の再燃が認められたため入院した。ゴリムマブおよび1日30mgのプレドニゾロンを開始し、臨床的寛解が得られた。しかし、ゴリムマブの7回目投与の際に全身倦怠感と発熱が認められた。インターフェロン-ガンマ放出アッセイは陽性で、胸水の結核(TB)に対するPCR検査も陽性であった。CT所見と合わせて、結核性胸膜炎と診断された。ゴリムマブを中断せずに標準的な抗結核治療(イソニアジド、リファンピシン、エタンブトール、ピラジナミド)を開始した。4週間後に発熱と胸水の増加が認められた。奇異性反応と診断し、プレドニゾロン30mgを投与し、症状は改善した。一般的にはTNF-α阻害薬を継続すればこのような奇異性反応は起こらないとされているが、本症例では、TNF-α阻害薬を継続していたにもかかわらず、奇異性反応が認められた。

  • Pirfenidone prevents esophageal stricture by inhibiting nucleotide binding oligomerization domain like receptor protein 3 inflammasome activation.

    Shinji Hirano, Akira Higashimori, Yasuaki Nagami, Yuji Nadatani, Tetsuya Tanigawa, Masaki Ominami, Shusei Fukunaga, Koji Otani, Shuhei Hosomi, Fumio Tanaka, Noriko Kamata, Koichi Taira, Toshio Watanabe, Yasuhiro Fujiwara

    Journal of gastroenterology and hepatology   37 ( 6 )   1096 - 1106   2022.06（ ISSN:0815-9319 ）

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    Publishing type：Research paper (scientific journal)   International / domestic magazine：International journal  

    BACKGROUND AND AIM: Esophageal injury often results in a scar, leading to refractory strictures. The NLRP3 inflammasome activates caspase-1, causing the maturation of interleukin (IL)-1β. Here, we aimed to investigate the preventive effect of pirfenidone (PFD), an antifibrotic drug, on esophageal stricture after ulcer healing and studied its mechanism by focusing on the activation of the NLRP3 inflammasome. METHODS: Esophageal ulcers were induced in rats via the local application of acetic acid in the serosa. PFD was intraperitoneally administered to the rats 3 days after ulcer induction. The effect of PFD on esophageal stricture after ulcer healing was assessed by esophagography on day 9. The protein levels of mature caspase-1 and IL-1β were assessed by western blotting. RESULTS: The ulcers fully developed 3 days after induction and were almost scarred by day 9 with severe strictures. PFD promoted ulcer healing and attenuated fibrotic collagen in the submucosa by suppressing the increase in NLRP3, cleaved caspase-1, and mature IL-1β expression, improving stricture rate (PFD vs vehicle = 55% vs 81%). Exogenous IL-1β abolished the therapeutic effects of PFD on ulcer healing and stricture formation. Furthermore, NLRP3 and caspase-1 inhibitors mimicked the effects of PFD on ulcer healing and stricture formation, with suppression of the increase in cleaved caspase-1 and mature IL-1β proteins and expression of fibrosis-related molecules including transforming growth factor (TGF)-β1. CONCLUSION: The NLRP3 inflammasome promotes esophageal stricture formation following ulcer healing, and PFD exerts potential prophylactic activity against strictures, possibly via the inhibition of the NLRP3/IL-1β/TGF-β1 axis.

    DOI： 10.1111/jgh.15861

    PubMed

  • A case of paradoxical response during anti-tuberculosis treatment in a patient with ulcerative colitis

    Shuhei Hosomi, Naoko Sugita, Atsushi Kanamori, Masaki Ominami, Koji Otani, Noriko Kamata, Fumio Tanaka, Yasuaki Nagami, Koichi Taira, Yasuhiro Fujiwara

    Clinical Journal of Gastroenterology   15 ( 3 )   592 - 597   2022.06（ ISSN:1865-7257 ）

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.1007/s12328-022-01616-6

    PubMed

    Other URL： https://link.springer.com/article/10.1007/s12328-022-01616-6/fulltext.html

  • Angle of covered self-expandable metallic stents after placement is a risk factor for recurrent biliary obstruction.

    Kojiro Tanoue, Hirotsugu Maruyama, Yuki Ishikawa-Kakiya, Yosuke Kinoshita, Kappei Hayashi, Masafumi Yamamura, Masaki Ominami, Yuji Nadatani, Shusei Fukunaga, Koji Otani, Shuhei Hosomi, Fumio Tanaka, Noriko Kamata, Yasuaki Nagami, Koichi Taira, Toshio Watanabe, Yasuhiro Fujiwara

    World journal of hepatology   14 ( 5 )   992 - 1005   2022.05（ ISSN:1948-5182 ）

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    Publishing type：Research paper (scientific journal)   International / domestic magazine：International journal  

    BACKGROUND: Studies have shown that covered self-expandable metallic stents (CSEMS) with a low axial forces after placement can cause early recurrent biliary obstruction (RBO) due to precipitating sludge formation. AIM: To ascertain whether the angle of CSEMS after placement is a risk factor for RBO in unresectable distal malignant biliary obstruction (MBO). METHODS: Between January 2010 and March 2019, 261 consecutive patients underwent self-expandable metallic stent insertion by endoscopic retrograde cholangiopancreatography at our facility, and 87 patients were included in this study. We evaluated the risk factors for RBO, including the angle of CSEMS after placement as the primary outcome. We measured the obtuse angle of CSEMS after placement on an abdominal radiograph using the SYNAPSE PACS system. We also evaluated technical and functional success, adverse events, time to RBO (TRBO), non-RBO rate, survival time, cause of RBO, and reintervention procedure as secondary outcomes. RESULTS: We divided the patients into two cohorts based on the presence or absence of RBO. The angle of CSEMS after placement (per 1° and per 10°) was evaluated using the multivariate Cox proportional hazard analysis, which was an independent risk factor for RBO in unresectable distal MBO [hazard ratio, 0.97 and 0.71; 95% confidence interval (CI): 0.94-0.99 and 0.54-0.92; P = 0.01 and 0.01, respectively]. For early diagnosis of RBO, the cut-off value of the angle of CSEMS after placement using the receiver operating characteristic curve was 130° [sensitivity, 50.0%; specificity 85.5%; area under the curve 0.70 (95%CI: 0.57-0.84)]. TRBO in the < 130° angle group was significantly shorter than that in the ≥ 130° angle group (P < 0.01). CONCLUSION: This study suggests that the angle of the CSEMS after placement for unresectable distal MBO is a risk factor for RBO. These novel results provide pertinent information for future stent management.

    DOI： 10.4254/wjh.v14.i5.992

    PubMed

  • COVID-19パンデミックが日本の食道運動障害に対するhigh-resolution manometryおよびperoral endoscopic myotomyへ与えた影響(Impact of the COVID-19 pandemic on high-resolution manometry and peroral endoscopic myotomy for esophageal motility disorder in Japan)

    Ominami Masaki, Sato Hiroki, Fujiyoshi Yusuke, Abe Hirofumi, Shiwaku Hironari, Shiota Junya, Sato Chiaki, Sakae Hiroyuki, Hata Yoshitaka, Fukuda Hisashi, Ogawa Ryo, Nakamura Jun, Tatsuta Tetsuya, Ikebuchi Yuichiro, Yokomichi Hiroshi, Fujiwara Yasuhiro, Inoue Haruhiro

    Digestive Endoscopy   34 ( 4 )   769 - 777   2022.05（ ISSN:0915-5635 ）

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    日本のhigh-volume center 14施設において、COVID-19パンデミックが食道運動障害患者に対するhigh-resolution manometry(HRM)およびperoral endoscopic myotomy(POEM)へ与えた影響について検討した。2020年のHRMおよびPOEMの施行件数は2019年に比べてそれぞれ17.2%、20.9%減少した。この減少は緊急事態宣言が発出された2020年4～5月にかけて、とくにパンデミック地域において顕著であった。2020年の同一県内におけるPOEM症例の減少は0.4%であったのに対し、県外からのPOEM症例は33.6%減少した。パンデミック下においてもPOEMの安全性と有効性は維持されていた。個人防護具(PPE)の着用については施設間に相違がみられ、POEM施行時のPPEはHRM施行時に比べて不十分であった。COVID-19パンデミックは日本のHRMおよびPOEMに影響を与えたことが示された。

  • Impact of the COVID-19 pandemic on high-resolution manometry and peroral endoscopic myotomy for esophageal motility disorder in Japan.

    Ominami M, Sato H, Fujiyoshi Y, Abe H, Shiwaku H, Shiota J, Sato C, Sakae H, Hata Y, Fukuda H, Ogawa R, Nakamura J, Tatsuta T, Ikebuchi Y, Yokomichi H, Fujiwara Y, Inoue H

    Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society   34 ( 4 )   769 - 777   2022.05（ ISSN:0915-5635 ）

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  • Development of Dilated Esophagus, Sigmoid Esophagus, and Esophageal Diverticulum in Patients With Achalasia: Japan Achalasia Multicenter Study Reviewed

    Hiroki Sato, Yusuke Fujiyoshi, Hirofumi Abe, Hironari Shiwaku, Junya Shiota, Chiaki Sato, Hiroyuki Sakae, Masaki Ominami, Yoshitaka Hata, Hisashi Fukuda, Ryo Ogawa, Jun Nakamura, Tetsuya Tatsuta, Yuichiro Ikebuchi, Hiroshi Yokomichi, Shuji Terai, Haruhiro Inoue

    Journal of Neurogastroenterology and Motility   28 ( 2 )   222 - 230   2022.04（ ISSN:2093-0879 ）

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    Publishing type：Research paper (scientific journal)   International / domestic magazine：International journal  

    BACKGROUND/AIMS: Patients with achalasia-related esophageal motility disorders (AEMDs) frequently present with dilated and sigmoid esophagus, and develop esophageal diverticulum (ED), although the prevalence and patients characteristics require further elucidation. METHODS: We conducted a multicenter cohort study of 3707 patients with AEMDs from 14 facilities in Japan. Esophagography on 3682 patients were analyzed. RESULTS: Straight (n = 2798), sigmoid (n = 684), and advanced sigmoid esophagus (n = 200) were diagnosed. Multivariate analysis revealed that long disease duration, advanced age, obesity, and type I achalasia correlate positively, whereas severe symptoms and integrated relaxation pressure correlate negatively with development of sigmoid esophagus. In contrast, Grade II dilation (3.5-6.0 cm) was the most common (52.9%), while grade III dilation (≥ 6 cm) was rare (5.0%). We found early onset, male, obesity, and type I achalasia correlated positively, while advanced age correlated negatively with esophageal dilation. Dilated and sigmoid esophagus were found mostly in types I and II achalasia, but typically not found in spastic disorders. The prevalence of ED was low (n = 63, 1.7%), and non-dilated esophagus and advanced age correlated with ED development. Patients with right-sided ED (n = 35) had a long disease duration (P = 0.005) with low integrated relaxation pressure values (P = 0.008) compared with patients with left-sided ED (n = 22). Patients with multiple EDs (n = 6) had lower symptom severity than patients with a single ED (P = 0.022). CONCLUSIONS: The etiologies of dilated esophagus, sigmoid esophagus, and ED are considered multifactorial and different. Early diagnosis and optimal treatment of AEMDs are necessary to prevent these conditions.

    DOI： 10.5056/jnm21188

    PubMed

  • 切除企図肝門部領域悪性胆道狭窄に対する術前至適なplastic stent留置とRBOの危険因子の検討

    田上 光治郎, 丸山 紘嗣, 藤原 靖弘, 島本 宜紀, 前田 夏美, 眞鍋 琢, 河野 光泰, 落合 正, 垣谷 有紀, 山村 匡史, 東森 啓, 大南 雅揮, 灘谷 祐二, 福永 周生, 大谷 恒史, 細見 周平, 鎌田 紀子, 田中 史生, 永見 康明, 平良 高一

    Gastroenterological Endoscopy   64 ( Suppl.1 )   813 - 813   2022.04（ ISSN:0387-1207 ）

  • 高齢者の食道扁平上皮癌ESDに対するTCI/BIS併用プロポフォールによる鎮静法の有用性

    大南 雅揮, 永見 康明, 藤原 靖弘, 島本 宜紀, 前田 夏美, 平野 慎二, 河野 光泰, 眞鍋 琢, 落合 正, 垣谷 有紀, 山村 匡史, 田上 光治郎, 丸山 紘嗣, 灘谷 祐二, 福永 周生, 大谷 恒史, 細見 周平, 田中 史生, 鎌田 紀子, 平良 高一

    Gastroenterological Endoscopy   64 ( Suppl.1 )   750 - 750   2022.04（ ISSN:0387-1207 ）

  • 難易度克服を目指した22G針を用いた超音波内視鏡下胆管胃吻合術

    丸山 紘嗣, 田上 光治郎, 藤原 靖弘, 島本 宜紀, 垣谷 有紀, 山村 匡史, 東森 啓, 大南 雅揮, 福永 周生, 大谷 恒史, 細見 周平, 鎌田 紀子, 田中 史生, 永見 康明, 平良 高一

    Gastroenterological Endoscopy   64 ( Suppl.1 )   812 - 812   2022.04（ ISSN:0387-1207 ）

  • 膵疾患に対する超音波内視鏡下穿刺吸引生検法におけるFNA針とFNB針の有用性と安全性に関する検討

    垣谷 有紀, 丸山 紘嗣, 藤原 靖弘, 島本 宜紀, 山村 匡史, 田上 光治郎, 東森 啓, 大南 雅揮, 福永 周生, 大谷 恒史, 細見 周平, 鎌田 紀子, 田中 史生, 永見 康明, 平良 高一

    Gastroenterological Endoscopy   64 ( Suppl.1 )   869 - 869   2022.04（ ISSN:0387-1207 ）

  • 健康診断時の慢性便秘症の疫学・病因に関する質問票調査(A questionnaire-based survey on the etiopathogenesis of chronic constipation during a medical check-up in Japan)

    Otani Koji, Watanabe Toshio, Takahashi Kanae, Ominami Masaki, Nadatani Yuji, Fukunaga Shusei, Hosomi Shuhei, Kamata Noriko, Tanaka Fumio, Nagami Yasuaki, Taira Koichi, Kimura Tatsuo, Fukumoto Shinya, Fujiwara Yasuhiro

    Journal of Clinical Biochemistry and Nutrition   70 ( 2 )   205 - 211   2022.03（ ISSN:0912-0009 ）

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    健康診断の受診者10658名のうち質問票調査で慢性便秘症(CC)の診断基準を満たした467名を対象として検討した。過敏性腸症候群(IBS)を有する者は21名であり、IBSのない者(n=446)と比べて睡眠障害やその他の症状を伴う頻度が高く、残便感や肛門直腸閉塞感の発生頻度が高かった。IBS者と非IBS者の排便頻度に有意差がみられた。順序ロジスティック回帰分析で、高い排便頻度と関連する因子はIBS、男性および日常的な運動であった。

  • A questionnaire-based survey on the etiopathogenesis of chronic constipation during a medical check-up in Japan

    Otani Koji, Watanabe Toshio, Takahashi Kanae, Ominami Masaki, Nadatani Yuji, Fukunaga Shusei, Hosomi Shuhei, Kamata Noriko, Tanaka Fumio, Nagami Yasuaki, Taira Koichi, Kimura Tatsuo, Fukumoto Shinya, Fujiwara Yasuhiro

    Journal of Clinical Biochemistry and Nutrition   70 ( 2 )   205 - 211   2022.03（ ISSN:0912-0009 ）

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    Publishing type：Research paper (scientific journal)   International / domestic magazine：Domestic journal  

    <p>The study group of the Japanese Society of Gastroenterology released evidence-based clinical practice guidelines for chronic constipation (CC) in 2017, and irritable bowel syndrome (IBS) was treated as one of the causes of CC. We examined the differences in characteristics between IBS and non-IBS subjects with CC who underwent a medical check-up in Japan. A total of 10,658 subjects participated in this study, and we focused on 467 subjects who fulfilled the diagnostic criteria of CC using a questionnaire survey. The number of IBS subjects was 21, and they had sleep disorders, were more symptomatic (e.g., abdominal pain, abdominal bloating/distension, feeling stressed, annoyance, lack of motivation, fatigue upon waking, and feeling depressed), and had more episodes of sensation of incomplete evacuation and anorectal obstruction/blockage during defecation than non-IBS subjects. Furthermore, stool frequency of IBS subjects was significantly different from non-IBS subjects. Multivariate ordinal logistic regression analysis revealed that the factors associated with a higher stool frequency were IBS [odds ratio (OR), 2.46; 95% confidence interval (CI), 1.00–6.05; <i>p</i> = 0.049], male sex (OR, 1.97; 95% CI, 1.20–3.23; <i>p</i> = 0.007), and regular exercise (OR, 1.80; 95% CI, 1.05–3.07; <i>p</i> = 0.033). These findings suggest that IBS has unique characteristics in subjects with CC.</p>

    DOI： 10.3164/jcbn.21-87

    PubMed

    CiNii Article

  • Clinical Implication of Preoperative C-Reactive Protein/Albumin Ratio in Malignant Transformation of Intraductal Papillary Mucinous Neoplasm: A Propensity Score Analysis.

    Hirotsugu Maruyama, Kojiro Tanoue, Yuki Ishikawa-Kakiya, Masafumi Yamamura, Akira Higashimori, Masaki Ominami, Yuji Nadatani, Shusei Fukunaga, Koji Otani, Shuhei Hosomi, Fumio Tanaka, Noriko Kamata, Yasuaki Nagami, Koichi Taira, Go Ohira, Kenjiro Kimura, Ryosuke Amano, Yasuhiro Fujiwara

    Diagnostics (Basel, Switzerland)   12 ( 2 )   2022.02（ ISSN:2075-4418 ）

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    Publishing type：Research paper (scientific journal)   International / domestic magazine：International journal  

    BACKGROUND: Inflammation-based scoring has been reported to be useful for predicting the recurrence and prognosis of various carcinomas. This study retrospectively investigated the relationship between inflammation-based score and intraductal papillary mucinous neoplasms (IPMNs). METHODS: Between January 2013 and October 2018, we enrolled 417 consecutive patients with pancreatic tumors who received surgical resections at our hospital. The main outcome was the association between the preoperative inflammation-based score and their accuracy in predicting malignant transformation of IPMN. RESULTS: Seventy six patients were eligible. Pathological findings indicated that 35 patients had low-grade dysplasia, 18 had high-grade dysplasia, and 23 had invasive carcinomas. As the C-reactive protein albumin ratio (CAR) was higher, malignant transformation of IPMNs also increased (p = 0.007). In comparing CARhigh and CARlow using cutoff value, the results using a propensity score analysis showed that the CARhigh group predicted malignant transformation of IPMNs (odds ratio, 4.18; 95% confidence interval, 1.37-12.8; p = 0.01). In the CARhigh group, disease-free survival (DFS) was significantly shorter (p = 0.04). In the worrisome features, the AUC for the accuracy of malignant transformation with CARhigh was 0.84 when combining with the MPD findings. CONCLUSIONS: Preoperative CAR could be a predictive marker of malignant transformation of IPMNs.

    DOI： 10.3390/diagnostics12020554

    PubMed

  • Prevalence and risk factor for chronic diarrhea in participants of a Japanese medical checkup.

    Yuji Matsumoto, Yuji Nadatani, Koji Otani, Akira Higashimori, Masaki Ominami, Shusei Fukunaga, Shuhei Hosomi, Noriko Kamata, Tatsuo Kimura, Shinya Fukumoto, Fumio Tanaka, Koichi Taira, Yasuaki Nagami, Toshio Watanabe, Yasuhiro Fujiwara

    JGH open : an open access journal of gastroenterology and hepatology   6 ( 1 )   69 - 75   2022.01

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    Publishing type：Research paper (scientific journal)   International / domestic magazine：International journal  

    BACKGROUND AND AIM: Although chronic diarrhea is a major digestive disorder, it has not been well studied. The aims of this study were to investigate the prevalence and risk factors of chronic diarrhea in the Japanese population and to assess the relationship between stool type and frequency and symptoms related to chronic diarrhea. METHOD: A total of 13 668 adults who underwent a medical checkup at MedCity21 were enrolled, and 9540 who met the inclusion criteria participated in the study. Participants with chronic diarrhea were defined as those who typically had a Bristol Stool Form Scale of type 6 or 7. RESULTS: The prevalence of chronic diarrhea was 3.0%. The risk factors for chronic diarrhea were younger age (odds ratio [OR] 0.984, 95% confidence interval [CI] 0.972-0.996), male sex (OR = 2.270, CI = 1.730-2.960), alcohol intake on ≥5 days per week (OR = 2.390, CI = 1.860-3.060), not getting adequate sleep (OR = 0.712, CI = 0.559-0.907), skipping breakfast ≥3 times a week (OR = 1.490, CI = 1.120-1.980), and absence of diabetes mellitus (OR = 0.384, CI = 0.179-0.824). Only 23.5% of the participants in the diarrhea group had ≥3 bowel movements per day. Chronic diarrhea was significantly associated with heartburn, nausea, stomach ache, abdominal bloating and distension, and feeling of stress. CONCLUSIONS: Our study shows that chronic diarrhea is common in Japan with a prevalence of 3.0%; unique risk factors related to gender, age, and irregular lifestyle were identified. An understanding of bowel habit in the healthy population is helpful for the assessment of change in bowel habit associated with gastrointestinal disorders.

    DOI： 10.1002/jgh3.12704

    PubMed

  • TECHNICAL TIPS ON HOW TO HANDLE DIFFICULT CASES OF ESOPHAGEAL ENDOSCOPIC SUBMUCOSAL DISSECTION

    NAGAMI Yasuaki, OMINAMI Masaki, FUJIWARA Yasuhiro

    GASTROENTEROLOGICAL ENDOSCOPY   64 ( 2 )   181 - 194   2022（ ISSN:03871207 ）

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    <p>Endoscopic submucosal dissection (ESD) is the standard treatment for superficial esophageal cancer. Over the years, this intervention has evolved and has employed several tools, such as carbon dioxide insufflation and traction methods. However, there are still difficult case of ESD, such as cervical esophageal cancers, entire-circumferential lesions, lesions located close to scars, esophago-gastric junctional cancers, lesions located on the diverticula, and lesions on the esophageal varices. We hereby present some technical tips for such difficult cases. Since difficult cases could have a higher risk of adverse events, recovering the solution and surgical operation beforehand should be considered. We thereby recommend performing ESD for these lesions after gaining basic and advanced ESD knowledge and techniques.</p>

    DOI： 10.11280/gee.64.181

    CiNii Article

  • Current real-world treatments for Japanese patients with eosinophilic esophagitis

    FUJIWARA Yasuhiro, TANAKA Fumio, NAKATA Rieko, KAKIYA Yuki, YAMAMURA Masafumi, TANOUE Kojiro, SAWADA Akinari, HIGASHIMORI Akira, NISHIDA Yu, MARUYAMA Hirotsugu, OMINAMI Masaki, NADATANI Yuji, FUKUNAGA Shusei, OTANI Koji, HOSOMI Shuhei, KAMATA Noriko, NAGAMI Yasuaki, TAIRA Koichi

    Nippon Shokakibyo Gakkai Zasshi   119 ( 10 )   929 - 936   2022（ ISSN:0446-6586 ）

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    <p>A total of 306 patients with eosinophilic esophagitis (EoE) were analyzed at our department. Proton pump inhibitors or potassium-competitive acid blockers were used as the first-line treatment in 286 (93.5%) patients. Fifty-five (18.0%) patients received topical steroid swallowing therapy. During 17.7-month mean follow-up, 46.4% of the patients were followed-up with no medications, 37.3% of the patients received maintenance or on-demand therapy using acid-suppressive drugs, and 9.8% of the patients received maintenance therapy with steroid swallowing. The majority of patients with EoE were treated using a therapeutic strategy similar to that used for gastroesophageal reflux disease. However, some patients were refractory to the treatment. Current real-world treatment strategies for Japanese patients with EoE are clarified.</p>

    DOI： 10.11405/nisshoshi.119.929

    PubMed

  • Acceptance of COVID-19 Vaccines among Patients with Inflammatory Bowel Disease in Japan.

    Yu Nishida, Shuhei Hosomi, Yumie Kobayashi, Rieko Nakata, Masaki Ominami, Yuji Nadatani, Shusei Fukunaga, Koji Otani, Fumio Tanaka, Yasuaki Nagami, Koichi Taira, Noriko Kamata, Yasuhiro Fujiwara

    Healthcare (Basel, Switzerland)   10 ( 1 )   2021.12（ ISSN:2227-9032 ）

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    Publishing type：Research paper (scientific journal)   International / domestic magazine：International journal  

    Coronavirus disease 2019 (COVID-19) vaccination is recommended for patients with inflammatory bowel disease (IBD). However, the acceptance of COVID-19 vaccines has not been sufficiently evaluated in patients with IBD. We aimed to assess the acceptance and hesitancy of COVID-19 vaccination and related factors among these patients. A retrospective cohort study using a self-reported questionnaire was performed among patients with IBD between 22 June 2021 and 30 August 2021. Of the 187 participants, 10.2% (n = 19) were hesitant to be vaccinated. Patients in the vaccine-hesitant group were younger (p = 0.009) and had a shorter disease duration (p = 0.020). Vedolizumab was prescribed more frequently (p = 0.024) and immunomodulators were less frequently used (p = 0.027) in this group. Multivariable logistic regression analysis identified age (odds ratio [OR]: 0.96, 95% confidence interval [CI]: 0.92-1.00, p = 0.042) and the use of immunomodulators (OR: 0.08, 95% CI: 0.01-0.66, p = 0.019) as independent significant factors for vaccine hesitancy. The COVID-19 vaccine hesitancy rate in patients with IBD in Japan was 10% in this study. The Japanese COVID-19 vaccination campaign appears to be successful. The risk of COVID-19 among patients with IBD requires adequate measures to ensure that vaccines are accepted by vaccine-hesitant patients. These findings may be helpful in achieving adequate vaccination rates.

    DOI： 10.3390/healthcare10010006

    PubMed

  • Ovariectomy-Induced Dysbiosis May Have a Minor Effect on Bone in Mice.

    Satoshi Kosaka, Yuji Nadatani, Akira Higashimori, Koji Otani, Kosuke Fujimoto, Yuki Nagata, Masaki Ominami, Shusei Fukunaga, Shuhei Hosomi, Noriko Kamata, Fumio Tanaka, Yasuaki Nagami, Koichi Taira, Seiya Imoto, Satoshi Uematsu, Toshio Watanabe, Yasuhiro Fujiwara

    Microorganisms   9 ( 12 )   2021.12（ ISSN:2076-2607 ）

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    Publishing type：Research paper (scientific journal)   International / domestic magazine：International journal  

    We determined the bone mineral density (BMD) and the expression of serum bone formation marker (procollagen type I N-terminal propeptide: PINP) and bone resorption marker (C-terminal telopeptide of collagen: CTX) by ELISA to evaluate ovariectomy-induced osteoporosis in ovariectomized (OVX) mice. The intestinal microbiota of the mice was assessed using 16S rRNA gene sequencing. OVX mice exhibited a lower BMD of 87% with higher serum levels of CTX and PINP compared to sham-operated (sham) mice. The cecum microbiome of OVX mice showed lower bacterial diversity than that of sham mice. TNFα mRNA levels in the colon were 1.6 times higher, and zonula occludens-1 mRNA and protein expression were lower in OVX mice than in sham mice, suggesting that ovariectomy induced inflammation and increased intestinal permeability. Next, we used antibiotic treatment followed by fecal microbiota transplantation (FMT) to remodel the gut microbiota in the OVX mice. A decrease in PINP was observed in antibiotic-treated mice, while there was no change in BMD or CTX between mice with and without antibiotic treatment. Oral transplantation of the luminal cecal content of OVX or sham mice to antibiotic-treated mice did not affect the BMD or PINP and CTX expression. Additionally, transplantation of the luminal contents of OVX or sham mice to antibiotic-treated OVX mice had similar effects on BMD, PINP, and CTX. In conclusion, although ovariectomy induces dysbiosis in the colon, the changes in the gut microbiota may only have a minor role in ovariectomy-induced osteoporosis.

    DOI： 10.3390/microorganisms9122563

    PubMed

  • 下大静脈平滑筋肉腫による転移と考えられた胆嚢平滑筋肉腫の一例

    住田 真衣子, 島本 宜紀, 丸山 紘嗣, 落合 正, 垣谷 有紀, 山村 匡史, 田上 光治郎, 東森 啓, 大南 雅揮, 灘谷 祐二, 福永 周生, 大谷 恒史, 細見 周平, 田中 史生, 永見 康明, 平良 高一, 田内 潤, 大平 豪, 坂本 香, 大澤 政彦, 藤原 靖弘

    日本消化器内視鏡学会近畿支部例会プログラム・抄録集   107回   102 - 102   2021.12

  • 非切除肝門部悪性胆道狭窄に対するフルカバー金属ステントを用いた内視鏡的胆道ステント留置術の多施設前向き研究

    木下 陽亮, 丸山 紘嗣, 垣谷 有紀, 林 克平, 山村 匡史, 田上 光治郎, 大南 雅揮, 福永 周生, 大谷 恒史, 細見 周平, 田中 史生, 永見 康明, 平良 高一, 渡辺 俊雄, 杉森 聖司, 江口 考明, 藤原 靖弘

    Gastroenterological Endoscopy   63 ( Suppl.2 )   2042 - 2042   2021.10（ ISSN:0387-1207 ）

  • Endoscopic Biopsy Technique using an Alcohol Swab to Prevent Transmission through the Instrument Channel in the COVID-19 Era.

    Shusei Fukunaga, Taku Manabe, Mitsuhiro Kono, Tadashi Ochiai, Akira Higashimori, Masaki Ominami, Yasuaki Nagami, Yasuhiro Fujiwara

    Clinical endoscopy   54 ( 5 )   771 - 773   2021.09（ ISSN:2234-2400 ）

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    Publishing type：Research paper (scientific journal)   International / domestic magazine：International journal  

    DOI： 10.5946/ce.2021.027

    PubMed

  • Predictive factors for difficult endoscopic submucosal dissection for esophageal neoplasia including failure of en bloc resection or perforation.

    Yasuaki Nagami, Masaki Ominami, Taishi Sakai, Hirotsugu Maruyama, Shusei Fukunaga, Koji Otani, Shuhei Hosomi, Fumio Tanaka, Noriko Kamata, Koichi Taira, Tetsuya Tanigawa, Masatsugu Shiba, Toshio Watanabe, Yasuhiro Fujiwara

    Surgical endoscopy   35 ( 7 )   3361 - 3369   2021.07（ ISSN:0930-2794 ）

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    Publishing type：Research paper (scientific journal)   International / domestic magazine：International journal  

    BACKGROUND: Endoscopic submucosal dissection (ESD) is accepted as the standard treatment for early-stage esophageal neoplasia. However, esophageal perforation may occur, leading to mediastinitis and pneumothorax, which occasionally require emergency surgery. Moreover, failure of en bloc resection causes local recurrence. However, studies on the predictors of such difficulties during ESD are limited. Hence, we evaluated the predictors associated with the difficulty of ESD for esophageal neoplasia including failure of en bloc resection or perforation. METHODS: Data of 549 consecutive patients who were treated with ESD between May 2004 and March 2016 at a single institution were retrospectively studied. Exclusion criteria were the presence of metachronous esophageal neoplasia or missing data. The primary outcome was determining the predictors associated with the difficulty of ESD for esophageal neoplasia including failure of en bloc resection or perforation. RESULTS: Altogether, 543 patients with 736 lesions were evaluated. Failure of en bloc resection occurred in 6 patients (1.1%) with 6 lesions, and perforation occurred in 11 patients (2.0%) with 11 lesions (1.5%). Multivariate logistic regression analysis showed that large lesion diameter (odds ratio [OR] 1.49; 95% confidence interval [CI] 1.21-1.84; p < 0.001) and previous chemoradiotherapy (OR 5.24; 95% CI 1.52-18.06; p = 0.009) were independent predictive factors. CONCLUSIONS: Larger lesions and previous chemoradiotherapy for esophageal cancer increased the risk for failure of en bloc resection or perforation in patients who underwent esophageal ESD.

    DOI： 10.1007/s00464-020-07777-0

    PubMed

  • 出血性過形成性ポリープ様形態を呈し、内視鏡的粘膜切除術により完全切除および診断し得た淡明細胞型腎細胞癌胃転移の一例

    田島 光, 眞鍋 琢, 大谷 恒史, 田上 光治郎, 沢田 明也, 東森 啓, 西田 裕, 丸山 紘嗣, 大南 雅揮, 灘谷 祐二, 福永 周生, 細見 周平, 田中 史生, 鎌田 紀子, 永見 康明, 平良 高一, 渡邉 俊雄, 藤原 靖弘

    日本消化器内視鏡学会近畿支部例会プログラム・抄録集   106回   95 - 95   2021.07

  • Gastrointestinal endoscopic practice during COVID-19 pandemic: a multi-institutional survey.

    Maruyama H, Hosomi S, Nebiki H, Fukuda T, Nakagawa K, Okazaki H, Yamagami H, Hara J, Tanigawa T, Machida H, Aomatsu K, Watanabe Y, Sato H, Uno H, Takaishi O, Nomura T, Ochi M, Oshitani N, Adachi K, Higashimori A, Ominami M, Nadatani Y, Fukunaga S, Otani K, Tanaka F, Kamata N, Nagami Y, Taira K, Watanabe T, Fujiwara Y

    Romanian journal of internal medicine = Revue roumaine de medecine interne   59 ( 2 )   166 - 173   2021.06（ ISSN:1220-4749 ）

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  • 内視鏡的内圧測定統合システム(EPSIS)は逆流性食道炎やバレット食道患者における胃食道接合部の機能を反映する

    岩谷 勇吾, 井上 晴洋, Rodriguez de Santiago Enrique, Abad Mary Raina Angeli, 藤吉 祐輔, 上野 明子, 田邊 万葉, 角 一弥, 富田 英臣, 大南 雅揮, 池田 晴夫, 鬼丸 学, 島村 勇人

    Gastroenterological Endoscopy   63 ( 6 )   1294 - 1302   2021.06（ ISSN:0387-1207 ）

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    【目的】内視鏡的内圧測定統合システム(endoscopic pressure study integrated system:EPSIS)は,胃内圧を測定することで胃食道逆流症(gastroesophageal reflux disease:GERD)の診断を行う,まったく新しい内視鏡機器である.この新たに開発された診療機器は,内視鏡的に下部食道括約筋(lower esophageal sphincter:LES)の機能を評価できる可能性を有している.本研究では,EPSISの測定結果と,びらん性食道炎やバレット食道に代表されるGERD関連疾患との関係性につき検討を行った.【方法】本研究は2016年11月から2018年7月にEPSISを行ったすべての患者を対象とした,後ろ向き・単施設研究である.EPSISでは,上部消化管内視鏡検査の施行中に,圧測定を行う専用機器に接続したカテーテルを内視鏡鉗子口から挿入し,最大胃内圧(IGP-Max)および胃内圧波形(FlatないしUphill)の測定を行う.びらん性食道炎とバレット食道の評価はロサンゼルス分類とプラハ分類を用いて行った.【結果】104人の患者が登録され,29人(28%)がびらん性食道炎を,42人(40%)がバレット食道を有していた.びらん性食道炎患者では食道炎の無い患者に比べ,最大胃内圧が低く(16.0 vs 18.8mmHg,P=0.01),Flatパターンがより高頻度に認められた(82.8% vs 37.3%,P<0.001).同様に,バレット食道患者ではバレット食道を認めない患者に比べ,最大胃内圧は低く(15.7 vs 19.6mmHg,P<0.001),Flatパターンが高頻度に認められた(69% vs 37.1%,P<0.001).これらの傾向は,多変量解析でも認められた.【結論】新しい診療機器であるEPSISの測定結果は,びらん性食道炎やバレット食道の存在と深い関連を有していた.これにより,EPSISがGERD関連疾患のLES機能評価を内視鏡的に行いうる可能性が示唆された.(著者抄録)

  • 超高齢者における早期胃癌に対するESDの妥当性

    大南 雅揮, 永見 康明, 藤原 靖弘, 山本 圭以, 平野 慎二, 河野 光泰, 眞鍋 琢, 落合 正, 垣谷 有紀, 山村 匡史, 田上 光治郎, 丸山 紘嗣, 灘谷 祐二, 福永 周生, 大谷 恒史, 細見 周平, 田中 史生, 鎌田 紀子, 平良 高一, 渡邉 俊雄

    Gastroenterological Endoscopy   63 ( Suppl.1 )   968 - 968   2021.04（ ISSN:0387-1207 ）

  • 悪性胆道狭窄の胆汁粘度とその後の胆道ステントの再閉塞の検討

    山本 圭以, 丸山 紘嗣, 藤原 靖弘, 眞鍋 琢, 河野 光泰, 落合 正, 垣谷 有紀, 中田 晃暢, 山村 匡史, 田上 光治郎, 東森 啓, 大南 雅揮, 灘谷 祐二, 福永 周生, 大谷 恒史, 細見 周平, 田中 史生, 鎌田 紀子, 永見 康明, 平良 高一, 渡邉 俊雄

    Gastroenterological Endoscopy   63 ( Suppl.1 )   972 - 972   2021.04（ ISSN:0387-1207 ）

  • Comparison of the Diagnostic Efficiency of Radial- and Convex-Arrayed Echoendoscopes for Indirect Findings of Pancreatic Cancer: A Retrospective Comparative Study Using Propensity Score Method.

    Yuki Ishikawa-Kakiya, Hirotsugu Maruyama, Kei Yamamoto, Masafumi Yamamura, Kojiro Tanoue, Akira Higashimori, Masaki Ominami, Yuji Nadatani, Shusei Fukunaga, Koji Otani, Shuhei Hosomi, Fumio Tanaka, Noriko Kamata, Yasuaki Nagami, Koichi Taira, Masatsugu Shiba, Toshio Watanabe, Yasuhiro Fujiwara

    Cancers   13 ( 6 )   1 - 13   2021.03（ ISSN:2072-6694 ）

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    Publishing type：Research paper (scientific journal)   International / domestic magazine：International journal  

    Endoscopic ultrasonography (EUS) is useful for detecting early-stage pancreatic cancer. Because the detection of small lesions is difficult, it is important to detect indirect findings, namely caliber change, retention cysts, and dilatation of the branch duct, during the procedure. Although two types of EUS endoscopes are frequently used, there is no comparative study on their efficacy for detecting indirect findings. Therefore, we aimed to compare the diagnostic efficacy of these two types for indirect findings. We retrospectively analyzed 316 consecutive patients who had undergone EUS for pancreaticobiliary disease at a single center between January 2017 and December 2018. The main outcome was the detection rate of indirect findings and its comparison between the two echoendoscope types. This outcome was achieved using the inverse probability of treatment weighting (IPTW) analysis. The detection rate of indirect findings was higher for the radial-arrayed endoscope than for the convex-arrayed echoendoscope (9.2% vs. 2.3% (p = 0.02)). The univariate analysis also revealed that the radial-arrayed echoendoscope was significantly superior to the convex-arrayed echoendoscope in terms of the detection of indirect findings (odds ratio, 5.94; 95% confidence interval, 1.68-21.10; p = 0.01) after IPTW. After adjustment for magnetic resonance imaging (MRI) and computed tomography (CT), radial-arrayed echoendoscope remained an independent factor for indirect finding detection (odds ratio, 6.04; 95% confidence interval, 1.74-21.00; p = 0.01). Finally, five patients who had indirect EUS findings were diagnosed with pancreatic cancer. Our results indicate that the radial-arrayed echoendoscope is useful for the detection of indirect findings.

    DOI： 10.3390/cancers13061217

    PubMed

  • Underwater endoscopic submucosal dissection for a duodenal neuroendocrine tumor using pocket creation and ring-shaped thread countertraction methods.

    Kono M, Nagami Y, Kitagawa D, Manabe T, Ominami M, Fukunaga S, Fujiwara Y

    Endoscopy   53 ( 3 )   E110 - E111   2021.03（ ISSN:0013-726X ）

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  • 直腸静脈瘤に対してCTガイド下直接穿刺アプローチにて静脈瘤硬化療法を施行した一例

    福井 純毅, 東森 啓, 金道 麻記子, 田上 光治郎, 沢田 明也, 西田 裕, 丸山 紘嗣, 大南 雅揮, 福永 周生, 灘谷 祐二, 大谷 恒史, 細見 周平, 田中 史生, 鎌田 紀子, 永見 康明, 平良 高一, 渡辺 俊雄, 藤原 靖弘

    日本消化器病学会近畿支部例会プログラム・抄録集   114回   68 - 68   2021.02

  • Ring-Shaped Thread Counter Traction-Assisted Endoscopic Retrograde Cholangiopancreatography of a Huge Periampullary Diverticula.

    Yuki Ishikawa-Kakiya, Hirotsugu Maruyama, Kei Yamamoto, Masafumi Yamamura, Kojiro Tanoue, Masaki Ominami, Shusei Fukunaga, Koichi Taira, Yasuaki Nagami, Toshio Watanabe, Yasuhiro Fujiwara

    The American journal of gastroenterology   116 ( 1 )   12 - 12   2021.01（ ISSN:0002-9270 ）

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    Publishing type：Research paper (scientific journal)   International / domestic magazine：International journal  

    DOI： 10.14309/ajg.0000000000000842

    PubMed

  • 消化管内視鏡診療とCOVID-19 多施設アンケート

    丸山 紘嗣, 細見 周平, 根引 浩子, 福田 隆, 仲川 浩一郎, 岡崎 博俊, 山上 博一, 原 順一, 谷川 徹也, 町田 浩久, 青松 和輝, 渡邊 芳久, 佐藤 博之, 宇野 裕典, 高石 修, 野村 勉, 越智 正博, 押谷 伸英, 足立 賢治, 東森 啓, 大南 雅揮, 灘谷 祐二, 福永 周生, 大谷 恒史, 田中 史生, 鎌田 紀子, 氷見 康明, 平良 高一, 渡邉 俊雄, 藤原 靖弘

    日本消化管学会雑誌   5 ( Suppl. )   116 - 116   2021.01（ ISSN:2433-3840 ）

  • Safety of Endoscopic Mucosal Resection Using a Bipolar Snare for Superficial Nonampullary Duodenal Epithelial Tumors and the Predictive Factors of Piecemeal Resection.

    Masafumi Yamamura, Yasuaki Nagami, Taishi Sakai, Hirotsugu Maruyama, Masaki Ominami, Shusei Fukunaga, Koji Otani, Shuhei Hosomi, Fumio Tanaka, Koichi Taira, Hirokazu Yamagami, Tetsuya Tanigawa, Toshio Watanabe, Yasuhiro Fujiwara

    Digestion   102 ( 5 )   682 - 690   2021（ ISSN:0012-2823 ）

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    Publishing type：Research paper (scientific journal)   International / domestic magazine：International journal  

    INTRODUCTION: Endoscopic mucosal resection for small superficial nonampullary duodenal epithelial tumors is a noninvasive treatment; however, perforations can occur. Bipolar snares can reduce the risk of perforation due to small tissue damage. Currently, only few studies have reported endoscopic mucosal resection for small superficial nonampullary duodenal epithelial tumors using a bipolar snare and the effect of preoperative findings. OBJECTIVE: To investigate (1) resectability and adverse events of endoscopic mucosal resection using a bipolar snare for small superficial nonampullary duodenal epithelial tumors and (2) the predictions of piecemeal resection. METHODS: Between 2007 and 2017, 89 patients with 107 lesions underwent endoscopic mucosal resection using a bipolar snare. Among them, 88 lesions of 77 patients were evaluated. The primary outcome was the incidence of en bloc resection and R0 resection and adverse events. Risk factors associated with piecemeal resection, including preoperative lesion findings, were also examined. RESULTS: The incidence rates of en bloc and R0 resections were 85.2 and 48.9%, respectively. Neither intraoperative or delayed perforations nor procedure-related mortality was noted. The nonlifting sign after submucosal injection was associated with an increase in piecemeal resection (odds ratio: 20.3, 95% confidence interval: 2.53-162; p = 0.005). CONCLUSION: Endoscopic resection for small superficial nonampullary duodenal epithelial tumors can cause perforation; however, endoscopic mucosal resection using a bipolar snare can be a safe treatment option as it does not cause perforations. The nonlifting sign after submucosal injection is a predictive factor for piecemeal resection.

    DOI： 10.1159/000510601

    PubMed

  • Successful Eradication of Helicobacter pylori Could Prevent Metachronous Gastric Cancer: A Propensity Matching Analysis. Reviewed

    Nakata R, Nagami Y, Hashimoto A, Sakai T, Ominami M, Fukunaga S, Otani K, Hosomi S, Tanaka F, Ohira M, Taira K, Yamagami H, Tanigawa T, Watanabe T, Fujiwara Y

    Digestion   102 ( 2 )   236 - 245   2021（ ISSN:0012-2823 ）

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.1159/000504132

    PubMed

  • Endoscopic findings of gastric lesions in patients with eosinophilic gastrointestinal disorders.

    Yasuhiro Fujiwara, Kojiro Tanoue, Akira Higashimori, Yu Nishida, Masatsugu Maruyama, Shigehiro Itani, Masaki Ominami, Yuji Nadatani, Shusei Fukunaga, Koji Otani, Shuhei Hosomi, Fumio Tanaka, Noriko Kamata, Yasuaki Nagami, Koichi Taira, Hirohisa Machida, Tetsuya Tanigawa, Toshio Watanabe, Masahiko Ohsawa

    Endoscopy international open   8 ( 12 )   E1817 - E1825   2020.12（ ISSN:2364-3722 ）

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    Publishing type：Research paper (scientific journal)   International / domestic magazine：International journal  

    Background and study aims  Eosinophilic gastrointestinal disorders are classified into eosinophilic esophagitis, eosinophilic gastritis, eosinophilic gastroenteritis, and eosinophilic colitis according to the site of eosinophilic infiltration. Although well established in eosinophilic esophagitis, endoscopic findings in eosinophilic gastritis and eosinophilic gastroenteritis with regard to gastric lesions have not been clearly described. The aim of this study was to identify endoscopic findings of gastric lesions associated with eosinophilic gastrointestinal disorders. Patients and methods  Out of 278 patients with eosinophilic gastrointestinal disorders, 18 had eosinophilic gastritis or eosinophilic gastroenteritis confirmed by biopsy; their endoscopic images were analyzed retrospectively. The association between endoscopic findings and number of eosinophils in the gastric mucosa was investigated. Results  Erythema was most frequently observed (72 %), followed by ulcers (39 %), discoloration (33 %), erosions (28 %), nodularity (28 %), and polyps (28 %). There were several unique endoscopic findings such as submucosal tumor-like deep large ulcers in three patients, antral Penthorum -like appearances (small nodules radially lined toward the pyloric ring) in three patients, "muskmelon-like appearances" (discolored mucosa-composed mesh pattern) in three patients, multiple white granular elevations in two patients, cracks (appearance of furrows similar to those in eosinophilic esophagitis) in five patients, and antral rings in one patient. No significant association was observed between endoscopic findings and number of gastric eosinophils. Conclusions  Several unique endoscopic findings of gastric lesions were observed in patients with eosinophilic gastritis or eosinophilic gastroenteritis. Submucosal tumor-like ulcers, antral Penthorum -like appearances, muskmelon-like appearances, and cracks might be associated with eosinophilic gastrointestinal disorders.

    DOI： 10.1055/a-1268-7312

    PubMed

  • 内視鏡的内圧測定統合システムはびらん性食道炎およびバレット食道の患者における胃食道接合部機能を反映する(Endoscopic pressure study integrated system reflects gastroesophageal junction competence in patients with erosive esophagitis and Barrett's esophagus)

    Iwaya Yugo, Inoue Haruhiro, Rodriguez de Santiago Enrique, Abad Mary Raina Angeli, Fujiyoshi Yusuke, Ueno Akiko, Tanabe Mayo, Sumi Kazuya, Tomida Hideomi, Ominami Masaki, Ikeda Haruo, Onimaru Manabu, Shimamura Yuto

    Digestive Endoscopy   32 ( 7 )   1050 - 1056   2020.11（ ISSN:0915-5635 ）

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    内視鏡的内圧測定統合システム(EPSIS)を使用した患者104名(女51名、平均54.1歳)を後ろ向きに検討した。EPSISで胃内圧最大値(IGP-max)および胃内圧波形パターンが記録された。患者104名中29名(28%)がびらん性食道炎(EE)、42名がバレット食道(BE)であった。単変量解析で、EE患者(n=29)はEEのない患者(n=75)と比べて低いIGP-max(16.0対18.8mmHg)を示し、EPSIS平坦パターンの頻度が高かった(82.8%対37.3%)。同様に、BE患者(n=42)はBEのない患者(n=62)と比べて低いIGP-max(15.7対19.6mmHg)を示し、EPSIS平坦パターンの頻度が高かった(69%対37.1%)。これらの差は多変量解析でも有意であった。以上より、EPSIS所見はEEおよびBEと関連し、胃食道逆流関連疾患および下部食道括約筋機能の評価に利用できると考えられた。

  • Safe technique of steroid injection utilizing submersion in saline to prevent stricture after esophageal endoscopic submucosal dissection.

    Nagami Y, Ominami M, Fujiwara Y

    Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society   32 ( 7 )   e169 - e170   2020.11（ ISSN:0915-5635 ）

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  • 総胆管結石に対する出血高危険度治療における出血・塞栓性偶発症の検討

    山村 匡史, 丸山 紘嗣, 山本 圭以, 眞鍋 琢, 木村 明恵, 垣谷 有紀, 林 克平, 田上 光治郎, 大南 雅揮, 福永 周生, 灘谷 裕二, 大谷 恒史, 細見 周平, 田中 史生, 鎌田 紀子, 平良 高一, 永見 康明, 谷川 徹也, 渡辺 俊雄, 藤原 靖弘

    Gastroenterological Endoscopy   62 ( Suppl.2 )   2122 - 2122   2020.10（ ISSN:0387-1207 ）

  • トレーニー施行における十二指腸鏡挿入困難である因子の検討 十二指腸乳頭正面視まで

    山本 圭以, 丸山 紘嗣, 田上 光治郎, 大南 雅揮, 福永 周生, 灘谷 祐二, 大谷 恒史, 細見 周平, 田中 史生, 鎌田 紀子, 平良 高一, 永見 康明, 谷川 徹也, 渡邊 俊雄, 藤原 靖弘

    Gastroenterological Endoscopy   62 ( Suppl.2 )   2122 - 2122   2020.10（ ISSN:0387-1207 ）

  • ESD後に外科手術が必要と考えられたpT1大腸癌の検討

    福永 周生, 永見 康明, 藤原 靖弘, 丸山 紘嗣, 大南 雅揮, 大谷 恒史, 細見 周平, 田中 史生, 平良 高一, 鎌田 紀子, 谷川 徹也, 渡辺 俊雄, 灘谷 祐二

    Gastroenterological Endoscopy   62 ( Suppl.1 )   1327 - 1327   2020.08（ ISSN:0387-1207 ）

  • 食道ESD後狭窄高リスク症例に対するステロイド局注、ポリグリコール酸シート併用狭窄予防の効果

    永見 康明, 大南 雅揮, 藤原 靖弘, 山本 圭以, 眞鍋 琢, 垣谷 有紀, 田上 光治郎, 山村 匡史, 林 克平, 坂井 大志, 丸山 紘嗣, 福永 周生, 大谷 恒史, 細見 周平, 田中 史生, 平良 高一, 谷川 徹也, 渡辺 俊雄

    Gastroenterological Endoscopy   62 ( Suppl.1 )   1212 - 1212   2020.08（ ISSN:0387-1207 ）

  • 非切除遠位悪性胆道狭窄に対するcovered selfexpandable metallic stent閉塞の危険因子の検討

    田上 光治郎, 丸山 紘嗣, 藤原 靖弘, 山本 圭以, 眞鍋 琢, 木村 明恵, 垣谷 有紀, 林 克平, 山村 匡史, 大南 雅揮, 福永 周生, 灘谷 祐二, 大谷 恒史, 細見 周平, 田中 史生, 平良 高一, 鎌田 紀子, 永見 康明, 谷川 徹也, 渡辺 俊雄

    Gastroenterological Endoscopy   62 ( Suppl.1 )   1342 - 1342   2020.08（ ISSN:0387-1207 ）

  • 胆膵疾患に対する出血高危険度処置における出血性偶発症の危険因子の検討

    山村 匡史, 丸山 紘嗣, 藤原 靖弘, 金道 麻紀子, 山本 圭以, 眞鍋 琢, 木村 明恵, 垣谷 有紀, 田上 光治郎, 林 克平, 大南 雅揮, 福永 周生, 灘谷 祐二, 大谷 恒史, 細見 周平, 田中 史生, 鎌田 紀子, 平良 高一, 永見 康明, 谷川 徹也, 渡辺 俊雄

    Gastroenterological Endoscopy   62 ( Suppl.1 )   1270 - 1270   2020.08（ ISSN:0387-1207 ）

  • 分枝型IPMNに対する悪性化のリスク因子および高齢者の経過観察期間の検討

    山本 圭以, 丸山 紘嗣, 藤原 靖弘, 金道 麻紀子, 眞鍋 琢, 木村 明恵, 垣谷 有紀, 田上 光治郎, 林 克平, 山村 匡史, 大南 雅揮, 福永 周生, 灘谷 祐二, 大谷 恒史, 細見 周平, 田中 史生, 鎌田 紀子, 平良 高一, 永見 康明, 谷川 徹也, 渡辺 俊雄

    Gastroenterological Endoscopy   62 ( Suppl.1 )   1288 - 1288   2020.08（ ISSN:0387-1207 ）

  • Wilson病の3例にみられた特徴的な内視鏡所見

    北川 大貴, 大南 雅揮, 平良 高一, 山村 匡史, 田上 光治郎, 林 克平, 西田 裕, 鋳谷 成弘, 丸山 紘嗣, 福永 周生, 灘谷 祐二, 大谷 恒史, 細見 周平, 永見 康明, 田中 史生, 鎌田 紀子, 谷川 徹也, 渡辺 俊雄, 藤原 靖弘

    Gastroenterological Endoscopy   62 ( Suppl.1 )   1279 - 1279   2020.08（ ISSN:0387-1207 ）

  • Repeated Endoscopic Submucosal Dissection for Esophageal Neoplasia Located Close to a Previous Endoscopic Submucosal Dissection Scar.

    Yasuaki Nagami, Masaki Ominami, Taishi Sakai, Hirotsugu Maruyama, Shusei Fukunaga, Koji Otani, Shuhei Hosomi, Fumio Tanaka, Koichi Taira, Noriko Kamata, Tetsuya Tanigawa, Masatsugu Shiba, Toshio Watanabe, Yasuhiro Fujiwara

    Clinical and translational gastroenterology   11 ( 8 )   e00226   2020.08

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    Publishing type：Research paper (scientific journal)   International / domestic magazine：International journal  

    INTRODUCTION: Endoscopic submucosal dissection (ESD) could become a standard treatment for early stage esophageal neoplasia. Recurrence sometimes develops close to a previous ESD scar. These lesions are predictably difficult to treat with ESD because of severe fibrosis. We evaluated the clinical outcomes of ESD for esophageal neoplasia located close to a previous ESD scar. METHODS: This was a retrospective observational study in a single institution. A total of 549 consecutive patients with 927 esophageal lesions were treated with ESD. The primary outcomes were resectability and adverse events of esophageal neoplasia located close to previous ESD scars (ESD scar group) than in primary esophageal ESD (primary group). Furthermore, predictive factors of perforation were examined. RESULTS: A total of 545 primary and 29 ESD scars in consecutive patients were evaluated. En bloc and complete (R0) resection rates in the ESD scar group were lower than those in the primary group (79.3% vs 98.3%, P < 0.01 and 75.9% vs 93.4%, P < 0.01). Perforations occurred more frequently in the ESD scar group (10.3% vs 2.0%, P = 0.03). The ESD scar group was a predictive factor for perforation (odds ratio = 10.37, 95% confidence interval: 2.15-49.94, P = 0.004). There were similar results for inverse probability of treatment weighting methods (odds ratio = 6.78, 95% confidence interval: 1.40-32.98, P = 0.018). DISCUSSION: ESD for esophageal neoplasia located close to a previous ESD scar was difficult to completely resect and increased the likelihood of perforation but could be a treatment option.

    DOI： 10.14309/ctg.0000000000000226

    PubMed

  • ESD後に局所再発を繰り返したバレット腺癌の一例

    眞鍋 琢, 大南 雅揮, 永見 康明, 福永 周生, 山本 圭以, 北川 大貴, 山村 匡史, 田上 光治郎, 林 克平, 丸山 紘嗣, 灘谷 祐二, 大谷 恒史, 細見 周平, 田中 史生, 鎌田 紀子, 平良 高一, 谷川 徹也, 渡辺 俊雄, 藤原 靖弘

    Gastroenterological Endoscopy   62 ( Suppl.1 )   1350 - 1350   2020.08（ ISSN:0387-1207 ）

  • 分枝型膵管内粘液性腫瘍に対する悪性化のリスク因子および高齢者の観察期間の検討

    山本 圭以, 丸山 紘嗣, 眞鍋 琢, 金道 麻記子, 木村 明恵, 垣谷 有紀, 田上 光治郎, 林 克平, 山村 匡史, 大南 雅揮, 福永 周生, 灘谷 祐二, 大谷 恒史, 細見 周平, 田中 史生, 平良 高一, 永見 康明, 谷川 徹也, 渡邊 俊雄, 藤原 靖弘

    膵臓   35 ( 3 )   A356 - A356   2020.07（ ISSN:0913-0071 ）

  • 分枝型膵管内粘液性腫瘍に対する悪性化のリスク因子および高齢者の観察期間の検討

    山本 圭以, 丸山 紘嗣, 眞鍋 琢, 金道 麻記子, 木村 明恵, 垣谷 有紀, 田上 光治郎, 林 克平, 山村 匡史, 大南 雅揮, 福永 周生, 灘谷 祐二, 大谷 恒史, 細見 周平, 田中 史生, 平良 高一, 永見 康明, 谷川 徹也, 渡邊 俊雄, 藤原 靖弘

    膵臓   35 ( 3 )   A356 - A356   2020.07（ ISSN:0913-0071 ）

  • ERCP後膵炎の予防策 膵臓の体積と内視鏡的逆行性胆管膵管造影後膵炎の関連性の検討

    丸山 紘嗣, 山本 圭以, 木村 明恵, 垣谷 有紀, 田上 光治郎, 林 克平, 山村 匡史, 大南 雅揮, 福永 周生, 永見 康明, 平良 高一, 渡辺 俊雄, 藤原 靖弘

    膵臓   35 ( 3 )   A230 - A230   2020.07（ ISSN:0913-0071 ）

  • IgG4関連硬化性胆管炎に胆管癌を合併した一例

    上村 拓也, 林 克平, 垣谷 有紀, 山村 匡史, 田上 光治郎, 西田 裕, 鋳谷 成弘, 丸山 紘嗣, 大南 雅揮, 福永 周生, 灘谷 祐二, 大谷 恒史, 細見 周平, 田中 史生, 鎌田 紀子, 平良 高一, 永見 康明, 谷川 徹也, 渡邉 俊雄, 藤原 靖弘

    日本消化器内視鏡学会近畿支部例会プログラム・抄録集   104回   75 - 75   2020.06

  • Endoscopic closure of refractory esophageal fistula after esophagectomy using polyglycolic acid sheets: a pilot study.

    Yasuaki Nagami, Masaki Ominami, Taishi Sakai, Shusei Fukunaga, Fumio Tanaka, Koichi Taira, Tetsuya Tanigawa, Shigeru Lee, Toshio Watanabe, Yasuhiro Fujiwara

    Endoscopy international open   8 ( 5 )   E591 - E595   2020.05（ ISSN:2364-3722 ）

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    Publishing type：Research paper (scientific journal)   International / domestic magazine：International journal  

    Background and study aims  Esophageal fistulas after esophagectomy are associated with high mortality and poor quality of life. They are sometimes intractable to conservative management and surgery that increases mortality. Few studies have assessed use of polyglycolic acid (PGA) sheets with fibrin glue for esophageal fistulas. We investigated the safety of using PGA sheets with fibrin glue for esophageal fistulas after esophagectomy. Patients and methods  This was a single-center prospective pilot study. Patients who had refractory esophageal fistulas after esophagectomy were included. PGA sheets were filled in the fistula using biopsy forceps. Fibrin glue was applied to the PGA sheets. We repeated the procedure 1 week later. The outcome measures were the incidence of adverse events (AEs) and closure of the fistula. Results  Five patients were assessed. No adverse events were observed. The esophageal fistula was closed with the application of PGA sheets four times in 40 % (2/5) of the cases. Conclusions  PGA sheets with fibrin glue were safe for esophageal fistula closure after esophagectomy and do not involve the risk of AEs.

    DOI： 10.1055/a-1119-6352

    PubMed

  • Positive correlation between pancreatic volume and Post-endoscopic retrograde cholangiopancreatography pancreatitis. Reviewed

    Maruyama H, Shiba M, Ishikawa-Kakiya Y, Kato K, Ominami M, Fukunaga S, Otani K, Hosomi S, Tanaka F, Kamata N, Taira K, Nagami Y, Yamagami H, Tanigawa T, Watanabe T, Yamamoto A, Kabata D, Shintani A, Fujiwara Y

    Journal of gastroenterology and hepatology   35 ( 5 )   769 - 776   2020.05（ ISSN:0815-9319 ）

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    Publishing type：Research paper (scientific journal)  

    Background and Aim Post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP) remains the most common and serious adverse event associated with ERCP. Risk factors for PEP have been described in various reports. However, risk factors have not been quantified to date. The aim of this study was to investigate the risk factors for PEP by quantification of pancreatic volume using pre-ERCP images. Methods Overall, 800 patients were recruited from April 2012 to February 2015 for this study. There were 168 patients who satisfied the inclusion criteria. Measurement of pancreatic volume was achieved using the volume analyzer SYNAPSE VINCENT in all cases and was used to evaluate the risk factors for PEP. Results According to the criteria established by the consensus guidelines (Cotton classification), 17 patients (10.1%) were classified as having mild disease, 4 (2.4%) as having moderate disease, and 5 (3.0%) as having severe disease. Multivariate model analysis showed that a large pancreatic volume was a significant risk factor for PEP (odds ratio [OR] 1.10, 95% confidence interval [CI] 1.06-1.13; P < 0.001). In addition, the association between the pancreatic volume and the severity of PEP was positively correlated (the effect of volume [per 1 mL]; OR 1.09, 95% CI 1.07-1.12; P < 0.001, the effect of volume [per 10 mL]; OR 2.27, 95% CI 1.72-3.00; P < 0.001). A larger pancreatic volume was significantly associated with a higher incidence of PEP. Conclusions A large pancreatic volume was identified as a risk factor for PEP. The results of this study suggest that pre-ERCP images might be useful for predicting PEP.

    DOI： 10.1111/jgh.14878

    PubMed

  • NBIで観察し内視鏡的粘膜下層剥離術で切除した肛門管癌の1例

    北坂 七瀬, 福永 周生, 眞鍋 琢, 垣谷 有紀, 田上 光治郎, 林 克平, 山村 匡史, 丸山 紘嗣, 大南 雅揮, 大谷 恒史, 細見 周平, 田中 史生, 永見 康明, 平良 高一, 鎌田 紀子, 山上 博一, 谷川 徹也, 斯波 将次, 渡辺 俊雄, 藤原 靖弘

    日本消化管学会雑誌   4 ( Suppl. )   324 - 324   2020.01（ ISSN:2433-3840 ）

  • NBIで観察し内視鏡的粘膜下層剥離術で切除した肛門管癌の1例 Reviewed

    北坂 七瀬, 福永 周生, 眞鍋 琢, 垣谷 有紀, 田上 光治郎, 林 克平, 山村 匡史, 丸山 紘嗣, 大南 雅揮, 大谷 恒史, 細見 周平, 田中 史生, 永見 康明, 平良 高一, 鎌田 紀子, 山上 博一, 谷川 徹也, 斯波 将次, 渡辺 俊雄, 藤原 靖弘

    日本消化管学会雑誌   4 ( Suppl. )   324 - 324   2020.01（ ISSN:2433-3840 ）

  • ESD後に追加手術が必要であった大腸T1癌の検討

    福永 周生, 永見 康明, 丸山 紘嗣, 大南 雅揮, 灘谷 裕二, 大谷 恒史, 細見 周平, 田中 史生, 平良 高一, 鎌田 紀子, 谷川 徹也, 斯波 将次, 渡辺 俊雄, 藤原 靖弘

    日本消化管学会雑誌   4 ( Suppl. )   265 - 265   2020.01（ ISSN:2433-3840 ）

  • ESDで切除した残胃の胃底腺型胃癌の一例 Reviewed

    山岸 政充, 福永 周生, 眞鍋 琢, 垣谷 有紀, 田上 光治郎, 林 克平, 山村 匡史, 丸山 紘嗣, 大南 雅揮, 大谷 恒文, 細見 周平, 田中 史生, 永見 康明, 鎌田 紀子, 平良 高一, 谷川 徹也, 山上 博一, 斯波 将次, 渡辺 俊雄, 藤原 靖弘

    日本消化管学会雑誌   4 ( Suppl. )   286 - 286   2020.01（ ISSN:2433-3840 ）

  • Endoscopic closure using polyglycolic acid sheets for delayed perforation after colonic endoscopic submucosal dissection. Reviewed

    Nagami Y, Fukunaga S, Kanamori A, Sakai T, Ominami M, Watanabe T, Fujiwara Y

    Endoscopy   52 ( 1 )   E11 - E12   2020.01（ ISSN:0013-726X ）

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.1055/a-0978-4501

    PubMed

  • 今月の主題 上部消化管感染症-最近の話題を含めて 症例アトラス 感染性食道炎 食道結核

    丸山 紘嗣, 垣谷 有紀, 田上 光治郎, 林 克平, 山村 匡史, 大南 雅揮, 福永 周生, 大谷 恒史, 田中 史生, 細見 周平, 鎌田 紀子, 平良 高一, 永見 康明, 谷川 徹也, 渡辺 俊雄, 藤原 靖弘

    胃と腸   54 ( 12 )   1614 - 1617   2019.11（ ISSN:05362180 ）

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  • 特集 大腸腫瘍の内視鏡治療戦略-攻めるか、引くか? 早期癌の治療方針　リンパ節転移リスクのうち、浸潤距離以外の因子がマイナスであれば、経過観察をすすめる　No

    福永 周生, 永見 康明, 片之坂 友喜, 丸山 紘嗣, 大南 雅揮, 平良 高一, 谷川 徹也, 斯波 将次, 渡辺 俊雄, 藤原 靖弘

    消化器内視鏡   31 ( 10 )   1556 - 1561   2019.10（ ISSN:09153217 ）

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  • 13. 頭頸部表在癌に対する ESD の治療成績と偶発症の危険因子の検討

    大南 雅揮, 永見 康明, 福永 周生, 藤原 靖弘

    耳鼻咽喉科展望   62 ( 5 )   240 - 240   2019.10（ ISSN:03869687 ）

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  • 悪性胆道狭窄に対する金属ステント留置後の膵炎と膵頭部膵管閉塞に関する検討 Reviewed

    木下 陽亮, 丸山 紘嗣, 垣谷 有紀, 田上 光治郎, 林 克平, 山村 匡史, 大南 雅揮, 福永 周生, 大谷 恒史, 細見 周平, 田中 史生, 永見 康明, 平良 高一, 山上 博一, 谷川 徹也, 渡辺 俊雄, 藤原 靖弘

    Gastroenterological Endoscopy   61 ( Suppl.2 )   2194 - 2194   2019.10（ ISSN:0387-1207 ）

  • 胃切除後Roux-enY再建における総胆管結石に対するEI-580BTの有用性の検討 Reviewed

    林 克平, 丸山 紘嗣, 垣谷 有紀, 木下 陽亮, 山村 匡史, 坂井 大志, 大南 雅揮, 灘谷 祐二, 福永 周生, 大谷 恒史, 細見 周平, 田中 史生, 永見 康明, 鎌田 紀子, 平良 高一, 山上 博一, 谷川 徹也, 渡邉 俊雄, 藤原 靖広

    Gastroenterological Endoscopy   61 ( Suppl.2 )   2215 - 2215   2019.10（ ISSN:0387-1207 ）

  • MULTIPLE LUGOL-VOIDING LESIONS INCREASE THE RISK FOR METACHRONOUS RECURRENCE AFTER ENDOSCOPIC SUBMUCOSAL DISSECTION OF SUPERFICIAL ESOPHAGEAL SQUAMOUS CELL CARCINOMA Reviewed

    Hirano Shinji, Nagami Yasuaki, Kakiya Yuki, Kinoshita Yosuke, Tanoue Koujiro, Hayashi Kappei, Yamamura Masafumi, Sakai Taishi, Maruyama Hirotsugu, Ominami Masaki, Fukunaga Shusei, Otani Koji, Hosomi Shuhei, Tanaka Fumio, Kamata Noriko, Taira Koichi, Yamagami Hirokazu, Tanigawa Tetsuya, Shiba Masatsugu, Watanabe Toshio, Fujiwara Yasuhiro

    GASTROINTESTINAL ENDOSCOPY   89 ( 6 )   AB206 - AB206   2019.06（ ISSN:0016-5107 ）

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    Publishing type：Research paper (scientific journal)  

  • SAFETY OF EMR USED A BIPOLAR SNARE FOR SUPERFICIAL NON-AMPULLARY DUODENAL EPITHELIAL TUMOR AND PREDICTIVE FACTOR OF PIECEMEAL RESECTION Reviewed

    Yamamura Masafumi, Nagami Yasuaki, Hirano Shinji, Kakiya Yuki, Kinoshita Yosuke, Tanoue Koujiro, Hayashi Kappei, Sakai Taishi, Maruyama Hirotsugu, Ominami Masaki, Fukunaga Shusei, Otani Koji, Hosomi Shuhei, Tanaka Fumio, Taira Koichi, Kamata Noriko, Yamagami Hirokazu, Tanigawa Tetsuya, Shiba Masatsugu, Watanabe Toshio, Fujiwara Yasuhiro

    GASTROINTESTINAL ENDOSCOPY   89 ( 6 )   AB356 - AB356   2019.06（ ISSN:0016-5107 ）

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    Publishing type：Research paper (scientific journal)  

  • RISK FACTORS FOR ADVERSE EVENTS OF ENDOSCOPIC SUBMUCOSAL DISSECTION FOR SUPERFICIAL PHARYNGEAL CANCER USING INVERSE PROBABILITY OF TREATMENT WEIGHTING Reviewed

    Ominami Masaki, Nagami Yasuaki, Hirano Shinji, Kakiya Yuki, Hayashi Kappei, Kinoshita Yosuke, Tanoue Koujiro, Yamamura Masafumi, Sakai Taishi, Maruyama Hirotsugu, Fukunaga Shusei, Otani Koji, Hosomi Shuhei, Tanaka Fumio, Kamata Noriko, Taira Koichi, Yamagami Hirokazu, Tanigawa Tetsuya, Shiba Masatsugu, Watanabe Toshio, Fujiwara Yasuhiro

    GASTROINTESTINAL ENDOSCOPY   89 ( 6 )   AB447 - AB447   2019.06（ ISSN:0016-5107 ）

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    Publishing type：Research paper (scientific journal)  

  • ORBIT SCORE PREDICTS MAJOR BLEEDING AFTER COLORECTAL POLYPECTOMY IN PATIENTS RECEIVING ORAL ANTICOAGULATION THERAPY Reviewed

    Fukunaga Shusei, Nagami Yasuaki, Ohira Mizuki, Sakai Taishi, Ominami Masaki, Maruyama Hirotsugu, Otani Koji, Hosomi Shuhei, Tanaka Fumio, Taira Koichi, Kamata Noriko, Yamagami Hirokazu, Tanigawa Tetsuya, Shiba Masatsugu, Watanabe Toshio, Fujiwara Yasuhiro

    GASTROINTESTINAL ENDOSCOPY   89 ( 6 )   AB381 - AB381   2019.06（ ISSN:0016-5107 ）

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  • 重症併存症がみられる患者の早期胃癌に対する内視鏡的粘膜下層剥離術の晩期成績　傾向スコアを用いた比較解析(Long-term outcome of endoscopic submucosal dissection for early gastric cancer in patients with severe comorbidities: a comparative propensity score analysis)

    Tanoue Kojiro, Fukunaga Shusei, Nagami Yasuaki, Sakai Taishi, Maruyama Hirotsugu, Ominami Masaki, Otani Koji, Hosomi Shuhei, Tanaka Fumio, Taira Koichi, Kamata Noriko, Yamagami Hirokazu, Tanigawa Tetsuya, Shiba Masatsugu, Watanabe Toshio, Fujiwara Yasuhiro

    Gastric Cancer   22 ( 3 )   558 - 566   2019.05（ ISSN:1436-3291 ）

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    早期胃癌の患者に対し内視鏡的粘膜下層剥離術(ESD)を施行した場合の晩期成績を重症併存症の有無で比較する後ろ向きコホート研究を施行した。早期胃癌に罹患し、当院にて2004年2月～2013年6月にESDを施行され、2016年7月まで経過観察が続けられた患者488名を解析対象とした。そのうち、米国麻酔科学会術前全身状態分類(ASA-PS)にてクラス1または2と分類された患者は375名(対照群)、3と分類され重症併存症を有すると定義された患者は113名(重症併存症群)であった。傾向スコア分析にて比較した結果、重症併存症群の5年全生存率は79.1%であり、対照群での87.7%よりも有意に低かった。Cox比例ハザード回帰分析およびinverse probability of treatment weighting法による分析を施行した結果、どちらの分析方法を用いた場合でも重症併存症群に属することは死亡に関し有意な危険因子となることが示された。有害事象については、傾向スコアマッチングを行った後の両群間において有意差は認められなかった。重症の併存症を有する早期胃癌患者では、重症併存症がみられない患者に比べESDの長期予後が悪化することが示された。

  • 重症併存症がみられる患者の早期胃癌に対する内視鏡的粘膜下層剥離術の晩期成績 傾向スコアを用いた比較解析(Long-term outcome of endoscopic submucosal dissection for early gastric cancer in patients with severe comorbidities: a comparative propensity score analysis) Reviewed

    Tanoue Kojiro, Fukunaga Shusei, Nagami Yasuaki, Sakai Taishi, Maruyama Hirotsugu, Ominami Masaki, Otani Koji, Hosomi Shuhei, Tanaka Fumio, Taira Koichi, Kamata Noriko, Yamagami Hirokazu, Tanigawa Tetsuya, Shiba Masatsugu, Watanabe Toshio, Fujiwara Yasuhiro

    シュプリンガー・ジャパン(株) Gastric Cancer   22 ( 3 )   558 - 566   2019.05（ ISSN:1436-3291 ）

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    Publishing type：Research paper (scientific journal)  

    早期胃癌の患者に対し内視鏡的粘膜下層剥離術(ESD)を施行した場合の晩期成績を重症併存症の有無で比較する後ろ向きコホート研究を施行した。早期胃癌に罹患し、当院にて2004年2月〜2013年6月にESDを施行され、2016年7月まで経過観察が続けられた患者488名を解析対象とした。そのうち、米国麻酔科学会術前全身状態分類(ASA-PS)にてクラス1または2と分類された患者は375名(対照群)、3と分類され重症併存症を有すると定義された患者は113名(重症併存症群)であった。傾向スコア分析にて比較した結果、重症併存症群の5年全生存率は79.1%であり、対照群での87.7%よりも有意に低かった。Cox比例ハザード回帰分析およびinverse probability of treatment weighting法による分析を施行した結果、どちらの分析方法を用いた場合でも重症併存症群に属することは死亡に関し有意な危険因子となることが示された。有害事象については、傾向スコアマッチングを行った後の両群間において有意差は認められなかった。

  • Long-term outcome of endoscopic submucosal dissection for early gastric cancer in patients with severe comorbidities: a comparative propensity score analysis.

    Tanoue K, Fukunaga S, Nagami Y, Sakai T, Maruyama H, Ominami M, Otani K, Hosomi S, Tanaka F, Taira K, Kamata N, Yamagami H, Tanigawa T, Shiba M, Watanabe T, Fujiwara Y

    Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association   22 ( 3 )   558 - 566   2019.05（ ISSN:1436-3291 ）

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  • Endoscopic technique for closure of a large gastric tube perforation by using endoclips with line-assisted complete closure Reviewed

    Ominami Masaki, Nagami Yasuaki, Tanaka Chieko, Sakai Taishi, Fukunaga Shusei, Watanabe Toshio, Fujiwara Yasuhiro

    ENDOSCOPY   51 ( 3 )   E49 - E50   2019.03（ ISSN:0013-726X ）

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.1055/a-0800-8502

    PubMed

  • Impact of preoperative biopsy sampling on severe submucosal fibrosis on endoscopic submucosal dissection for colorectal laterally spreading tumors: a propensity score analysis.

    Fukunaga S, Nagami Y, Shiba M, Sakai T, Maruyama H, Ominami M, Otani K, Hosomi S, Tanaka F, Taira K, Tanigawa T, Yamagami H, Watanabe T, Fujiwara Y

    Gastrointestinal endoscopy   89 ( 3 )   470 - 478   2019.03（ ISSN:0016-5107 ）

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  • 大阪市立大学医学部附属病院 内視鏡センター:責任者：藤原靖弘 〒545-8586 大阪府大阪市阿倍野区旭町1-5-7 Reviewed

    大南 雅揮, 永見 康明

    GASTROENTEROLOGICAL ENDOSCOPY   61 ( 8 )   1599 - 1603   2019（ ISSN:03871207 ）

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.11280/gee.61.1599

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MISC

  • 食道ESD困難症例に対する対策

    永見 康明, 大南 雅揮, 藤原 靖弘

    Gastroenterological Endoscopy   64 ( 2 )   181 - 194   2022.02（ ISSN:0387-1207 ）

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    表在型食道癌に対するESDはCO2送気やトラクション法の普及に伴ってより標準的治療となってきている.しかし,頸部食道癌,全周性病変,瘢痕に接する病変,放射線化学療法後,憩室にかかる病変,食道胃接合部癌,食道静脈瘤合併症例などは治療困難とされ,その対策についてそれぞれ解説する.これらの病変ではより偶発症のリスクが高く,基本的な手技の習熟,経験を積んだうえで,偶発症に対しての対応や外科手術対応も想定,準備し行う必要がある.(著者抄録)

  • 食道の内視鏡的粘膜下層剥離術後の狭窄予防のための生理食塩液による浸水を用いた安全なステロイド注入手技(Safe technique of steroid injection utilizing submersion in saline to prevent stricture after esophageal endoscopic submucosal dissection)

    Nagami Yasuaki, Ominami Masaki, Fujiwara Yasuhiro

    Digestive Endoscopy   32 ( 7 )   e169 - e170   2020.11（ ISSN:0915-5635 ）

  • 【上部消化管感染症-最近の話題を含めて】症例アトラス 感染性食道炎 食道結核

    丸山 紘嗣, 垣谷 有紀, 田上 光治郎, 林 克平, 山村 匡史, 大南 雅揮, 福永 周生, 大谷 恒史, 田中 史生, 細見 周平, 鎌田 紀子, 平良 高一, 永見 康明, 谷川 徹也, 渡辺 俊雄, 藤原 靖弘

    胃と腸   54 ( 12 )   1614 - 1617   2019.11（ ISSN:0536-2180 ） （ eISSN:1882-1219 ）

  • 【上部消化管感染症-最近の話題を含めて】症例アトラス　感染性食道炎　食道結核

    丸山 紘嗣, 垣谷 有紀, 田上 光治郎, 林 克平, 山村 匡史, 大南 雅揮, 福永 周生, 大谷 恒史, 田中 史生, 細見 周平, 鎌田 紀子, 平良 高一, 永見 康明, 谷川 徹也, 渡辺 俊雄, 藤原 靖弘

    胃と腸   54 ( 12 )   1614 - 1617   2019.11（ ISSN:0536-2180 ）

  • Peutz-Jegehers syndromeに膵癌を発症した一例

    三崎 絢子, 山村 匡史, 丸山 紘嗣, 垣谷 有紀, 田上 光治郎, 林 克平, 西田 裕, 鋳谷 成弘, 大南 雅揮, 福永 周生, 灘谷 祐二, 大谷 恒史, 細見 周平, 田中 史生, 鎌田 紀子, 平良 高一, 永見 康明, 谷川 徹也, 渡邉 俊雄, 藤原 靖弘

    日本消化器病学会近畿支部例会プログラム・抄録集   111回   87 - 87   2019.10

  • 胃切除後Roux-enY再建における総胆管結石に対するEI-580BTの有用性の検討

    林 克平, 丸山 紘嗣, 垣谷 有紀, 木下 陽亮, 山村 匡史, 坂井 大志, 大南 雅揮, 灘谷 祐二, 福永 周生, 大谷 恒史, 細見 周平, 田中 史生, 永見 康明, 鎌田 紀子, 平良 高一, 山上 博一, 谷川 徹也, 渡邉 俊雄, 藤原 靖広

    Gastroenterological Endoscopy   61 ( Suppl.2 )   2215 - 2215   2019.10（ ISSN:0387-1207 ） （ eISSN:1884-5738 ）

  • 悪性胸膜中皮腫に対し化学療法施行中に膵転移を来した一例

    北川 大貴, 垣谷 有紀, 丸山 紘嗣, 田上 光治郎, 林 克平, 山村 匡史, 鋳谷 成弘, 大南 雅揮, 福永 周生, 灘谷 裕二, 大谷 恒史, 細見 周平, 田中 史生, 鎌田 紀子, 平良 高一, 永見 康明, 谷川 徹也, 渡辺 俊雄, 藤原 靖弘

    日本消化器病学会近畿支部例会プログラム・抄録集   111回   88 - 88   2019.10

  • 悪性胸膜中皮腫に対し化学療法施行中に膵転移を来した一例

    北川 大貴, 垣谷 有紀, 丸山 紘嗣, 田上 光治郎, 林 克平, 山村 匡史, 鋳谷 成弘, 大南 雅揮, 福永 周生, 灘谷 裕二, 大谷 恒史, 細見 周平, 田中 史生, 鎌田 紀子, 平良 高一, 永見 康明, 谷川 徹也, 渡辺 俊雄, 藤原 靖弘

    日本消化器病学会近畿支部例会プログラム・抄録集   111回   88 - 88   2019.10

  • 悪性胆道狭窄に対する金属ステント留置後の膵炎と膵頭部膵管閉塞に関する検討

    木下 陽亮, 丸山 紘嗣, 垣谷 有紀, 田上 光治郎, 林 克平, 山村 匡史, 大南 雅揮, 福永 周生, 大谷 恒史, 細見 周平, 田中 史生, 永見 康明, 平良 高一, 山上 博一, 谷川 徹也, 渡辺 俊雄, 藤原 靖弘

    Gastroenterological Endoscopy   61 ( Suppl.2 )   2194 - 2194   2019.10（ ISSN:0387-1207 ） （ eISSN:1884-5738 ）

  • 【大腸腫瘍の内視鏡治療戦略-攻めるか、引くか?】早期癌の治療方針　リンパ節転移リスクのうち、浸潤距離以外の因子がマイナスであれば、経過観察をすすめる　No

    福永 周生, 永見 康明, 片之坂 友喜, 丸山 紘嗣, 大南 雅揮, 平良 高一, 谷川 徹也, 斯波 将次, 渡辺 俊雄, 藤原 靖弘

    消化器内視鏡   31 ( 10 )   1556 - 1561   2019.10（ ISSN:0915-3217 ）

  • 【大腸腫瘍の内視鏡治療戦略-攻めるか、引くか?】早期癌の治療方針 リンパ節転移リスクのうち、浸潤距離以外の因子がマイナスであれば、経過観察をすすめる No

    福永 周生, 永見 康明, 片之坂 友喜, 丸山 紘嗣, 大南 雅揮, 平良 高一, 谷川 徹也, 斯波 将次, 渡辺 俊雄, 藤原 靖弘

    消化器内視鏡   31 ( 10 )   1556 - 1561   2019.10（ ISSN:0915-3217 ）

  • Peutz-Jegehers syndromeに膵癌を発症した一例

    三崎 絢子, 山村 匡史, 丸山 紘嗣, 垣谷 有紀, 田上 光治郎, 林 克平, 西田 裕, 鋳谷 成弘, 大南 雅揮, 福永 周生, 灘谷 祐二, 大谷 恒史, 細見 周平, 田中 史生, 鎌田 紀子, 平良 高一, 永見 康明, 谷川 徹也, 渡邉 俊雄, 藤原 靖弘

    日本消化器病学会近畿支部例会プログラム・抄録集   111回   87 - 87   2019.10

  • 十二指腸乳頭部腫瘍に対する内視鏡的乳頭切除術の偶発症における性差を含めた検討

    山村 匡史, 丸山 弘嗣, 垣谷 有紀, 田上 光治郎, 林 克平, 西田 裕, 鋳谷 成弘, 大南 雅揮, 福永 周生, 灘谷 裕二, 大谷 恒史, 細見 周平, 田中 史生, 鎌田 紀子, 平良 高一, 永見 康明, 谷川 徹成, 斯波 将次, 渡辺 俊雄, 藤原 靖弘

    日本高齢消化器病学会誌   22 ( 1 )   139 - 139   2019.07（ ISSN:1881-0837 ）

  • 十二指腸乳頭部腫瘍に対する内視鏡的乳頭切除術の偶発症における性差を含めた検討

    山村 匡史, 丸山 弘嗣, 垣谷 有紀, 田上 光治郎, 林 克平, 西田 裕, 鋳谷 成弘, 大南 雅揮, 福永 周生, 灘谷 裕二, 大谷 恒史, 細見 周平, 田中 史生, 鎌田 紀子, 平良 高一, 永見 康明, 谷川 徹成, 斯波 将次, 渡辺 俊雄, 藤原 靖弘

    日本高齢消化器病学会誌   22 ( 1 )   139 - 139   2019.07（ ISSN:1881-0837 ）

  • A NEWLY DEVELOPED DIAGNOSTIC TOOL FOR GERD AND NERD: ENDOSCOPIC PRESSURE STUDY INTEGRATED SYSTEM (EPSIS)

    Yuto Shimamura, Anastassios C. Manolakis, Enrique Rodriguez de Santiago, Yasutoshi Kobayashi, Masaki Ominami, Yusuke Fujiyoshi, Hisashi Fukuda, Hideomi Tomida, Kazuya Sumi, Yugo Iwaya, Haruo Ikeda, Manabu Onimaru, Haruhiro Inoue

    GASTROINTESTINAL ENDOSCOPY   89 ( 6 )   AB197 - AB197   2019.06（ ISSN:0016-5107 ） （ eISSN:1097-6779 ）

    　More details

    Publishing type：Research paper, summary (international conference)  

    DOI： 10.1016/j.gie.2019.03.160

  • 当院での肝門部領域胆管狭窄に対するInside Stentの有用性と安全性の検討

    林 克平, 丸山 紘嗣, 藤原 靖弘, 渡邉 俊雄, 谷川 徹也, 山上 博一, 平良 高一, 鎌田 紀子, 永見 康明, 田中 史生, 細見 周平, 大谷 恒史, 福永 周生, 灘谷 祐二, 大南 雅揮, 坂井 大志, 木下 陽亮, 田上 光治郎, 山村 匡史, 垣谷 有紀, 平野 慎二

    Gastroenterological Endoscopy   61 ( Suppl.1 )   863 - 863   2019.05（ ISSN:0387-1207 ） （ eISSN:1884-5738 ）

  • 食道Verrucous Carcinomaに対して内視鏡的粘膜下層剥離術を施行した一例

    黒川 達哉, 坂井 大志, 大南 雅揮, 山村 匡史, 木下 陽亮, 田上 光治郎, 林 克平, 丸山 紘嗣, 福永 周生, 細見 周平, 田中 史生, 永見 康明, 平良 高一, 鎌田 紀子, 桑江 優子, 山上 博一, 谷川 徹也, 斯波 将次, 渡辺 俊雄, 藤原 靖弘

    Gastroenterological Endoscopy   61 ( Suppl.1 )   894 - 894   2019.05（ ISSN:0387-1207 ） （ eISSN:1884-5738 ）

  • 食道Verrucous Carcinomaに対して内視鏡的粘膜下層剥離術を施行した一例

    黒川 達哉, 坂井 大志, 大南 雅揮, 山村 匡史, 木下 陽亮, 田上 光治郎, 林 克平, 丸山 紘嗣, 福永 周生, 細見 周平, 田中 史生, 永見 康明, 平良 高一, 鎌田 紀子, 桑江 優子, 山上 博一, 谷川 徹也, 斯波 将次, 渡辺 俊雄, 藤原 靖弘

    Gastroenterological Endoscopy   61 ( Suppl.1 )   894 - 894   2019.05（ ISSN:0387-1207 ）

  • 食道ESDにおける穿孔および一括切除不成功の予測因子

    永見 康明, 大南 雅揮, 坂井 大志, 垣谷 有紀, 木下 陽亮, 田上 光治郎, 林 克平, 山村 匡史, 丸山 紘嗣, 福永 周生, 大谷 恒史, 細見 周平, 田中 史生, 平良 高一, 鎌田 紀子, 山上 博一, 谷川 徹也, 斯波 将次, 渡辺 俊雄, 藤原 靖弘

    Gastroenterological Endoscopy   61 ( Suppl.1 )   934 - 934   2019.05（ ISSN:0387-1207 ） （ eISSN:1884-5738 ）

  • 食道ESDにおける穿孔および一括切除不成功の予測因子

    永見 康明, 大南 雅揮, 坂井 大志, 垣谷 有紀, 木下 陽亮, 田上 光治郎, 林 克平, 山村 匡史, 丸山 紘嗣, 福永 周生, 大谷 恒史, 細見 周平, 田中 史生, 平良 高一, 鎌田 紀子, 山上 博一, 谷川 徹也, 斯波 将次, 渡辺 俊雄, 藤原 靖弘

    Gastroenterological Endoscopy   61 ( Suppl.1 )   934 - 934   2019.05（ ISSN:0387-1207 ）

  • 頭頸部表在癌に対するESDの治療成績と偶発症の危険因子

    大南 雅揮, 永見 康明, 平野 慎二, 垣谷 有紀, 林 克平, 木下 陽亮, 田上 光治郎, 山村 匡史, Sakai Taishi, 丸山 紘嗣, 福永 周生, 大谷 恒史, 細見 周平, 田中 史生, 鎌田 紀子, 平良 高一, 山上 博一, 谷川 徹也, 斯波 将次, 渡辺 俊雄, 藤原 靖弘

    Gastroenterological Endoscopy   61 ( Suppl.1 )   917 - 917   2019.05（ ISSN:0387-1207 ） （ eISSN:1884-5738 ）

  • 頭頸部表在癌に対するESDの治療成績と偶発症の危険因子

    大南 雅揮, 永見 康明, 平野 慎二, 垣谷 有紀, 林 克平, 木下 陽亮, 田上 光治郎, 山村 匡史, Sakai Taishi, 丸山 紘嗣, 福永 周生, 大谷 恒史, 細見 周平, 田中 史生, 鎌田 紀子, 平良 高一, 山上 博一, 谷川 徹也, 斯波 将次, 渡辺 俊雄, 藤原 靖弘

    Gastroenterological Endoscopy   61 ( Suppl.1 )   917 - 917   2019.05（ ISSN:0387-1207 ）

  • 表在型食道扁平上皮癌ESD後の食道内異時性癌に関する危険因子の検討

    平野 慎二, 永見 康明, 垣谷 有紀, 木下 陽亮, 田上 光治郎, 林 克平, 山村 匡史, 坂井 大志, 丸山 紘嗣, 大南 雅揮, 福永 周生, 大谷 恒史, 細見 周平, 田中 史生, 平良 高一, 鎌田 紀子, 山上 博一, 谷川 徹也, 斯波 将次, 渡辺 俊雄, 藤原 靖弘

    Gastroenterological Endoscopy   61 ( Suppl.1 )   894 - 894   2019.05（ ISSN:0387-1207 ）

  • 表在型食道扁平上皮癌ESD後の食道内異時性癌に関する危険因子の検討

    平野 慎二, 永見 康明, 垣谷 有紀, 木下 陽亮, 田上 光治郎, 林 克平, 山村 匡史, 坂井 大志, 丸山 紘嗣, 大南 雅揮, 福永 周生, 大谷 恒史, 細見 周平, 田中 史生, 平良 高一, 鎌田 紀子, 山上 博一, 谷川 徹也, 斯波 将次, 渡辺 俊雄, 藤原 靖弘

    Gastroenterological Endoscopy   61 ( Suppl.1 )   894 - 894   2019.05（ ISSN:0387-1207 ） （ eISSN:1884-5738 ）

  • 当院での肝門部領域胆管狭窄に対するInside Stentの有用性と安全性の検討

    林 克平, 丸山 紘嗣, 藤原 靖弘, 渡邉 俊雄, 谷川 徹也, 山上 博一, 平良 高一, 鎌田 紀子, 永見 康明, 田中 史生, 細見 周平, 大谷 恒史, 福永 周生, 灘谷 祐二, 大南 雅揮, 坂井 大志, 木下 陽亮, 田上 光治郎, 山村 匡史, 垣谷 有紀, 平野 慎二

    Gastroenterological Endoscopy   61 ( Suppl.1 )   863 - 863   2019.05（ ISSN:0387-1207 ）

  • 【膵管intervention】膵炎予防のための自然脱落型膵管ステント

    丸山 紘嗣, 垣谷 有紀, 木下 陽亮, 田上 光治郎, 林 克平, 山村 匡史, 大南 雅揮, 福永 周生, 細見 周平, 田中 史生, 平良 高一, 永見 康明, 山上 博一, 谷川 徹也, 渡辺 俊雄, 藤原 靖弘

    消化器・肝臓内科   5 ( 3 )   278 - 284   2019.03（ ISSN:2432-3446 ）

  • 膵管内乳頭粘液性腫瘍の"造影される5mm以上の壁在結節"の検討

    田上 光治郎, 丸山 紘嗣, 垣谷 有紀, 木下 陽亮, 林 克平, 山村 匡史, 坂井 大志, 大南 雅揮, 福永 周生, 大谷 恒史, 細見 周平, 田中 史生, 永見 康明, 平良 高一, 鎌田 紀子, 山上 博一, 谷川 徹也, 渡辺 俊雄, 藤原 靖弘

    日本消化器病学会雑誌   116 ( 臨増総会 )   A312 - A312   2019.03（ ISSN:0446-6586 ） （ eISSN:1349-7693 ）

  • 膵管内乳頭粘液性腫瘍の"造影される5mm以上の壁在結節"の検討

    田上 光治郎, 丸山 紘嗣, 垣谷 有紀, 木下 陽亮, 林 克平, 山村 匡史, 坂井 大志, 大南 雅揮, 福永 周生, 大谷 恒史, 細見 周平, 田中 史生, 永見 康明, 平良 高一, 鎌田 紀子, 山上 博一, 谷川 徹也, 渡辺 俊雄, 藤原 靖弘

    日本消化器病学会雑誌   116 ( 臨増総会 )   A312 - A312   2019.03（ ISSN:0446-6586 ）

  • 【膵管intervention】膵炎予防のための自然脱落型膵管ステント

    丸山 紘嗣, 垣谷 有紀, 木下 陽亮, 田上 光治郎, 林 克平, 山村 匡史, 大南 雅揮, 福永 周生, 細見 周平, 田中 史生, 平良 高一, 永見 康明, 山上 博一, 谷川 徹也, 渡辺 俊雄, 藤原 靖弘

    消化器・肝臓内科   5 ( 3 )   278 - 284   2019.03（ ISSN:2432-3446 ）

  • 急激な経過で発症したCronkhite-Canada症候群の1例

    岡原 一樹, 灘谷 祐二, 林 克平, 坂井 大志, 杉田 奈央子, 西田 裕, 鋳谷 成弘, 丸山 弘嗣, 大南 雅揮, 福永 周生, 大谷 恒史, 細見 周平, 田中 史生, 永見 康明, 鎌田 紀子, 平良 高一, 山上 博一, 谷川 徹也, 渡辺 俊雄, 藤原 靖弘

    日本消化器病学会近畿支部例会プログラム・抄録集   110回   107 - 107   2019.02

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