Updated on 2024/01/31

写真a

 
Nomoto Akihiro
 
Organization
Graduate School of Engineering Division of Science and Engineering for Materials, Chemistry and Biology Associate Professor
School of Engineering Department of Applied Chemistry
Title
Associate Professor
Affiliation
Institute of Engineering

Position

  • Graduate School of Engineering Division of Science and Engineering for Materials, Chemistry and Biology 

    Associate Professor  2022.04 - Now

  • School of Engineering Department of Applied Chemistry 

    Associate Professor  2022.04 - Now

Degree

  • 博士(工学) ( Others )

Research Areas

  • Nanotechnology/Materials / Structural organic chemistry and physical organic chemistry

  • Life Science / Bioorganic chemistry

  • Life Science / Medical systems  / PDT薬剤合成

  • Nanotechnology/Materials / Synthetic organic chemistry

  • Manufacturing Technology (Mechanical Engineering, Electrical and Electronic Engineering, Chemical Engineering) / Catalyst and resource chemical process

  • Nanotechnology/Materials / Thin film/surface and interfacial physical properties

  • Nanotechnology/Materials / Inorganic/coordination chemistry  / 生物無機化学

  • Nanotechnology/Materials / Green sustainable chemistry and environmental chemistry  / 環境低負荷型色素合成

  • Nanotechnology/Materials / Bio chemistry  / 光がん治療薬合成

  • Nanotechnology/Materials / Inorganic/coordination chemistry

  • Life Science / Medical systems  / 光がん治療薬合成

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Research Interests

  • 有機合成化学

  • 錯体化学

  • 有機金属化学

  • photodynamic therapy agent

  • 表面化学

  • 生物無機化学

  • 巨大パイ共役系ナノデバイス

  • 光線力学療法

  • 光医療化学

  • がん治療錯体化学

Research subject summary

  • 光線力学療法用薬剤の合成

  • 糖部位を有する抗がん錯体薬剤の開発

  • システインを検出可能な発光プローブの開発

  • 空気による酸化反応を触媒する錯体触媒の合成

  • 水系における希土類ナノ粒子の合成

  • 希土類試薬を用いた光による二酸化炭素固定反応の開発

  • イオウを含む共役系分子の選択的合成と新機能開拓

Research Career

  • ヘテロ元素の反応性を利用した環境低負荷型反応の開発

    Joint Research in Japan

    2005.04 - Now 

  • 医工連携に基づく光・化学抗がん薬剤の開発

    Joint Research in Japan

    2010.04 - Now 

  • 希土類を用いた光二酸化固定化反応

    希土類ナノ粒子、二酸化炭素固定、増炭素型触媒反応 

    2005.04 - Now 

  • 錯体化学

    ヘテロ原子、ポルフィリン、フェロセン、蛍光 

    2005.04 - Now 

Professional Memberships

  • レーザー医学会

    2023.01 - Now   Domestic

  • 日本光線力学学会

    2023.01 - Now   Domestic

  • 先端錯体工学会

    2011.09 - Now   Domestic

  • 錯体化学会

    2011.05 - Now   Domestic

  • ケイ素学会

    2008.09 - Now   Domestic

  • ヨウ素学会

    2006.09 - Now   Domestic

  • 有機合成化学協会

    2005.06 - Now   Domestic

  • 電気化学会

    2004.09 - Now   Domestic

  • 日本化学会

    1995.02 - Now   Domestic

  • 日本化学会

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Committee Memberships (off-campus)

  • 第110回テクノラボツアー講師   第110回テクノラボツアー講師  

    2018.04 - 2019.03 

  • 第62回テクノラボツアー講師   第62回テクノラボツアー講師  

    2014.04 - 2015.03 

Awards

  • 文部科学省ナノテクノロジープラットフォーム「秀でた利用成果」優秀賞

    2021.12   文部科学省ナノテクノロジープラットフォーム  

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    Country:Japan

  • 先端錯体工学研究会賞

    2021.03   先端錯体工学研究会  

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    Country:Japan

  • 色材研究発表会優秀ポスター賞

    2018.10   一般社団法人色材協会  

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    Country:Japan

  • 先端錯体工学研究会奨励賞

    2013.04   先端錯体工学研究会  

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    Country:Japan

Job Career (off-campus)

  • 「生体のエネルギー変換・信号伝達機能の全構築」博士研究員

Papers

  • Air/liquid interfacial formation process of conductive metal–organic framework nanosheets

    Ohata T.

    Journal of Colloid and Interface Science   651   769 - 784   2023.12( ISSN:00219797

  • Crystal structure of (l-hydrogen disulfato)-l-oxidobis[( 4,4'-di-tert-butyl-2,2'-bipyridine)oxidovanadium( IV/V)] acetonitrile monosolvate

    Kodama S.

    Acta Crystallographica Section E: Crystallographic Communications   79 ( Pt 11 )   1055 - 1058   2023.10

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  • Boron Clusters Alter the Membrane Permeability of Dicationic Fluorescent DNA-Staining Dyes

    Hirai Y.

    ACS Omega   8 ( 38 )   35321 - 35327   2023.09

  • Vascular-targeted photodynamic therapy with glucose-conjugated chlorin e6 for dogs with spontaneously occurring tumours.

    Tomohiro Osaki, Shota Hibino, Yusuke Murahata, Takao Amaha, Inoru Yokoe, Masamichi Yamashita, Akihiro Nomoto, Shigenobu Yano, Mamoru Tanaka, Hiromi Kataoka, Yoshiharu Okamoto

    Veterinary medicine and science   9 ( 6 )   2534 - 2541   2023.09

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    Publishing type:Research paper (scientific journal)   International / domestic magazine:International journal  

    BACKGROUND: Photodynamic therapy (PDT) using photosensitisers is a minimally invasive treatment for malignant tumours. However, ideal photosensitisers are not yet established. Recently, we developed a new photosensitiser, glucose-conjugated chlorin e6 (G-Ce6). OBJECTIVES: To evaluate the clinical efficacy of vascular-targeted PDT (VTP), a type of PDT utilising a short drug-light interval, using G-Ce6 to treat spontaneously occurring tumours in dogs. METHODS: Five dogs with spontaneously occurring tumours (malignant melanoma: three; haemangiopericytoma: two; and squamous cell carcinoma: one) were subjected to VTP. These dogs were intravenously injected with G-Ce6 at doses of 1-3 mg/kg 5 min before laser irradiation. Tumours were superficially or interstitially irradiated using a 677-nm diode laser. RESULTS: Repeated VTP decreased tumour size, yielding complete remission in three dogs. Complications such as oedema surrounding normal tissues and fistulae were observed, and the oedema was self-limiting. The fistula was cured by debriding the necrotic tissues formed after VTP. CONCLUSIONS: Our findings demonstrate that VTP using G-Ce6 had antitumour effects in dogs with spontaneously occurring tumours.

    DOI: 10.1002/vms3.1263

    PubMed

  • Assembling Triphenylene-Based Metal–Organic Framework Nanosheets at the Air/Liquid Interface: Modification by Tuning the Spread Solution Concentration Reviewed

    Kazuaki Tachimoto, Takashi Ohata, Kanokwan Jumtee Takeno, Akihiro nomoto, Takeshi Watanabe, Ichiro Hirosawa, Rie Makiura

    Langmuir   39 ( 26 )   8952 - 8962   2023.06( ISSN:07437463

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/acs.langmuir.2c02685

    PubMed

  • A Nonionic Octanuclear Vanadium(V) Oxide Cluster Complex as a Precatalyst for Visible-Light Photooxidation of Alcohols under O<sub>2</sub> Atmosphere

    Shintaro Kodama, Terushi Hashiguchi, Akira Okumura, Akihiro Nomoto, Akiya Ogawa

    Chemistry Letters   52 ( 6 )   473 - 476   2023.05( ISSN:0366-7022

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    Publishing type:Research paper (scientific journal)  

    <p>An octanuclear vanadium(V) oxide cluster complex, [V<sub>8</sub>O<sub>20</sub>(4,4′-<i><sup>t</sup></i>Bubpy)<sub>4</sub>], having a nonionic V<sub>8</sub>O<sub>20</sub> core functionalized with 4,4′-di-<i>tert</i>-butyl-2,2′-bipyridine (4,4′-<i><sup>t</sup></i>Bubpy) ligands can be employed for the visible-light photooxidation of alcohols (ROH) by molecular oxygen. In the present reaction, heptanuclear oxido(alkoxido)vanadium(V) complexes, [V<sub>7</sub>O<sub>17</sub>(OR)(4,4′-<i><sup>t</sup></i>Bubpy)<sub>3</sub>], generated in situ from [V<sub>8</sub>O<sub>20</sub>(4,4′-<i><sup>t</sup></i>Bubpy)<sub>4</sub>] and ROH are proposed to be key catalyst intermediates.</p>

    DOI: 10.1246/cl.230144

  • Development of Next-generation Glycoconjugated Photosensitizers for Photodynamic Therapy for Clinical Application

    Yano Shigenobu, Kataoka Hiromi, Tanaka Mamoru, Narumi Atushi, Nomoto Akihiro, Osaki Tomohiro, Okamoto Yoshiharu

    The Journal of Japan Society for Laser Surgery and Medicine   44 ( 1 )   36 - 46   2023.04( ISSN:02886200

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    <p>A long-standing goal in the field of cancer therapy is the ability to treat tumors noninvasively. Photodynamic therapy (PDT) has attracted attention as a less invasive method for treating cancer. Thus, we focused on the sugar conjugation of photosensitizers (chlorin, C<sub>60</sub> etc.), mainly to improve their biocompatibility and tumor selectivity. We have developed sugar (glucose, mannose, maltotriose etc.)-conjugated chlorins as third-generation photosensitizers for PDT and glucose conjugated chlorin e6 (G-Ce6), especially, shows excellent PDT effects <i>in vitro</i> and <i>in vivo</i>. In addition, excellent PDT effects have been observed in dog cancer models.</p>

    DOI: 10.2530/jslsm.jslsm-44_0008

  • Influence of the Solvent on the Assembly of Ni<inf>3</inf>(hexaiminotriphenylene)<inf>2</inf> MetalOrganic Framework Nanosheets at the Air/Liquid Interface

    Takashi Ohata, Kazuaki Tachimoto, Kanokwan Jumtee Takeno, Akihiro Nomoto, Takeshi Watanabe, Ichiro Hirosawa, Rie Makiura

    Bulletin of the Chemical Society of Japan   96 ( 3 )   274 - 282   2023.03( ISSN:0009-2673

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    Publishing type:Research paper (scientific journal)  

    Nanosheets of metalorganic frameworks (MOFs)®porous crystalline materials consisting of metal ions and organic ligands®are actively studied for their intrinsic chemical/physical properties attributed to the reduced dimensionality and for their potential to function as ideal components of nanodevices, especially when electrical conduction is present. Air/liquid interfacial synthesis is a promising technique to obtain highly oriented MOF nanosheets. However, rational control of size and shape combined with the aimed functionality remains an important issue to address making it necessary to research the critical factors governing nanosheet characteristics in the interfacial synthesis. Here, we investigate the influence of the solvent®methanol (MeOH) versus N, N-dimethylformamide (DMF)®used to prepare a ligand spread solution on an assembly of MOF nanosheets composed of Ni2+ and 2,3,6,7,10,11-hexaiminotriphenylene (HITP) (HITP-Ni-NS). We find that the macroscopic morphological uniformity in the micrometer scale is higher when DMF is used as the solvent. Regarding the microscopic crystalline domain, molecules of DMF with relatively high polarity and boiling point are involved in HITP-Ni-NS formation, hindering its growth and resulting in nanosheets with slightly smaller lateral size than that grown when MeOH is used. These findings provide crucial guidelines towards establishing a judicious strategy for creating desired MOF nanosheets at the air/liquid interface, thereby driving forward research on both fundamental and applied aspects of this field.

    DOI: 10.1246/bcsj.20220283

  • Anti-tumor effect of mannose-conjugated chlorin e6 photodynamic therapy targeting M2-like tumor-associated macrophages

    Aoki Hiromasa, Toriuchi Kohki, Nomoto Akihiro, Yano Shigenobu, Nishie Hirotada, Kataoka Hiromi, Aoyama Mineyoshi

    Proceedings for Annual Meeting of The Japanese Pharmacological Society   97 ( 0 )   3-B-P-061   2023

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    <p>M2-like tumor-associated macrophages (M2-TAMs) in cancer tissues play a key role in cancer progression and immune evasion. Therefore, cancer immunotherapies targeting M2-TAMs have attracted considerable attention. Photodynamic therapy (PDT) is a minimally invasive and site-selective approach that kills target cells using a visible laser and a nontoxic photosensitizer. The photosensitizer is activated by the laser and produces reactive oxygen species (ROS) that induce cell death of target cells. We developed a novel photosensitizer, mannose-conjugated chlorin e6 (M-chlorin e6), which can be selectively delivered to M2-TAMs that highly express mannose receptors (CD206). We evaluated the anti-tumor effect of M-chlorin e6 PDT in a mouse model of allogeneic transplantation of CT26 cells, a murine colon cancer cell line. M-chlorin e6 PDT significantly reduced tumor volume and weight compared to the control group. M-chlorin e6 PDT also decreased the percentage of M2-TAMs (CD11b<sup>+</sup>, CD206<sup>+</sup>) and increased the percentage of M1-TAMs (CD11b<sup>+</sup>, CD80<sup>+</sup> or CD86<sup>+</sup>, CD206<sup>-</sup>) in the tumor tissue. Moreover, M-chlorin e6 PDT directly inhibited cancer cell viability and enhanced phagocytosis by the macrophage cell line RAW264.7. These results suggest that M-chlorin e6 PDT exerts its anti-tumor effect by reduction of M2-TAMs, inducing cancer cell death, and promoting macrophage phagocytosis.</p>

    DOI: 10.1254/jpssuppl.97.0_3-b-p-061

  • Direct synthesis and characterization of endohedral zinc(II) hemicryptophane complex Reviewed

    Yoshimasa Makita, Yuya Akagi, Yuka Aoyagi, Genta Yakabe, Yuya Hirai, Akihiro Nomoto, Shin ichi Fujiwara, Akiya Ogawa

    Tetrahedron Letters   107   2022.09( ISSN:0040-4039

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    Publishing type:Research paper (scientific journal)   International / domestic magazine:International journal  

    Endohedral metal hemicryptophanes are attractive metal complexes with secondary coordination sphere models. Here, an endohedral Zn(II) hemicryptophane complex is directly synthesized using a triethylene glycol chain as a moderate length spacer between the cyclotriguaiacylene (CTG) and quinolinol units of the novel tripodal ligand. The guest of choline was encapsulated within the cavity of Zn(II) hemicryptophane complex.

    DOI: 10.1016/j.tetlet.2022.154103

  • Innovative Green Oxidation of Amines to Imines under Atmospheric Oxygen Reviewed

    Yuki Yamamoto, Shintaro Kodama, Akihiro Nomoto, Akiya Ogawa

    Organic &amp; Biomolecular Chemistry   20   9503 - 9521   2022.09( ISSN:1477-0520

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    Publishing type:Research paper (scientific journal)   International / domestic magazine:International journal  

    In recent years, the development of environmentally benign molecular construction methods has been of great importance, and especially, resource recycling, high atomic efficiency, and low environmental impact are strongly demanded....

    DOI: 10.1039/d2ob01421a

  • ヘテロ原子を含有する光感受性化合物の構造決定と抗がん光線力学療法への応用 Invited

    野元 昭宏, 矢野 重信, 片岡 洋望

    NanotechJapan Bulletin   15   1 - 5   2022.05

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    Authorship:Lead author, Corresponding author   Publishing type:Research paper (scientific journal)   International / domestic magazine:Domestic journal  

  • Photodynamic therapy using mannose-conjugated chlorin e6 increases cell surface calreticulin in cancer cells and promotes macrophage phagocytosis.

    Yuka Kimura, Hiromasa Aoki, Tatsuki Soyama, Akira Sakuragi, Yuto Otsuka, Akihiro Nomoto, Shigenobu Yano, Hirotada Nishie, Hiromi Kataoka, Mineyoshi Aoyama

    Medical oncology (Northwood, London, England)   39 ( 5 )   82 - 82   2022.04

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    Publishing type:Research paper (scientific journal)   International / domestic magazine:International journal  

    Photodynamic therapy (PDT) damages cancer cells via photosensitization using harmless laser irradiation. We synthesized a new photosensitizer, mannose-conjugated-chlorin e6 (M-chlorin e6), which targets mannose receptors that are highly expressed on M2-like tumor-associated macrophages (M2-TAMs) and cancer cells. In our previous study, we demonstrated that M-chlorin e6 PDT reduces tumor volume and decreases the proportion of M2-TAMs. Whether M-chlorin e6 PDT-treated cancer cells activate tumor immunity remains unclear, although the decrease in M2-TAMs is thought to be a direct injurious effect of M-chlorin e6 PDT. Calreticulin (CRT) is exposed at the surface of the membrane of cancer cells in response to treatment with chemotherapeutic agents such as anthracycline and oxaliplatin. Surface-exposed CRT induces phagocytosis of CRT receptor-positive cells, including macrophages, inducing anticancer immune responses. In the present study, we found that M-chlorin e6 PDT increases CRT on the surface of cancer cells, leading to macrophage phagocytosis of cancer cells. Furthermore, M-chlorin e6 PDT increases CD80+CD86+ macrophages. These results suggest that M-chlorin e6 PDT exerts anti-tumor effects by both enhancing the phagocytosis of cancer cells and strengthening the anti-tumor phenotype of macrophages.

    DOI: 10.1007/s12032-022-01674-3

    PubMed

  • Metal-Free Synthesis of 2-Substituted Quinazolines via Green Oxidation of o-Aminobenzylamines: Practical Construction of N-Containing Heterocycles Based on a Salicylic Acid-Catalyzed Oxidation System

    Yuki Yamamoto, Chihiro Yamakawa, Riku Nishimura, Chun-Ping Dong, Shintaro Kodama, Akihiro Nomoto, Michio Ueshima, Akiya Ogawa

    Frontiers in Chemistry   9   2022.02

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    Publishing type:Research paper (scientific journal)  

    Conventional quinazoline synthesis methods involve a highly multistep reaction, and often require excess amounts of substrate to control the product selectivity, leading to significant resource wastage. Hence, in this study, from the viewpoint of green chemistry, we developed a novel metal-free synthetic method for 2-substituted quinazoline derivatives by the 4,6-dihydroxysalicylic acid-catalyzed oxidative condensation of <italic>o</italic>-aminobenzylamines and benzylamines using atmospheric oxygen. In this system, the use of a catalytic amount of BF<sub>3</sub>‧Et<sub>2</sub>O (10 mol%) as a Lewis acid successfully led to the efficient oxidative condensation and intramolecular cyclization of these amines, followed by aromatization to afford the corresponding 2-arylquinazolines in up to 81% yield with excellent atom economy and environmental factor. Furthermore, to expand this green oxidation method to gram-scale synthesis, we investigated the development of an oxidation process using salicylic acid itself as an organocatalyst, and established a method for the practical green synthesis of a series of nitrogen-containing heterocycles. We expect that the findings will contribute to the development of practical synthesis methods for pharmaceutical manufacturing and industrial applications, along with further advancements in green chemistry.

    DOI: 10.3389/fchem.2021.822841

  • Photoinduced Bisphosphination of Alkynes with Phosphorus Interelement Compounds and Its Application to Double-Bond Isomerization.

    Yamamoto Y, Tanaka R, Kodama S, Nomoto A, Ogawa A

    Molecules (Basel, Switzerland)   27 ( 4 )   2022.02

  • Transition-Metal-Free Synthesis of Unsymmetrical Diaryl Tellurides via S<sub>H</sub>2 Reaction of Aryl Radicals on Tellurium.

    Yamamoto Y, Sato F, Chen Q, Kodama S, Nomoto A, Ogawa A

    Molecules (Basel, Switzerland)   27 ( 3 )   2022.01

  • A two-phase bromination process using tetraalkylammonium hydroxide for the practical synthesis of α-bromolactones from lactones

    Yuki Yamamoto, Akihiro Tabuchi, Kazumi Hosono, Takanori Ochi, Kento Yamazaki, Shintaro Kodama, Akihiro Nomoto, Akiya Ogawa

    Beilstein Journal of Organic Chemistry   17   2906 - 2914   2021.12

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    Publishing type:Research paper (scientific journal)  

    A simple and efficient method for α-brominating lactones that affords α<italic>-</italic>bromolactones under mild conditions using tetraalkylammonium hydroxide (R<sub>4</sub>N<sup>+</sup>OH<sup>−</sup>) as a base was developed. Lactones are ring-opened with Br<sub>2</sub> and a substoichiometric amount of PBr<sub>3</sub>, leading to good yields of the corresponding α-bromocarboxylic acids. Subsequent intramolecular cyclization over 1 h using a two-phase system (H<sub>2</sub>O/CHCl<sub>3</sub>) containing R<sub>4</sub>N<sup>+</sup>OH<sup>−</sup> afforded α-bromo lactones in good yields. This method can be applied at the 10 mmol scale using simple operations. α-Bromo-δ-valerolactone, which is extremely reactive and difficult to isolate, could be isolated and stored in a freezer for about one week using the developed method. Optimizing the solvent for environmentally friendly large-scale syntheses revealed that methyl ethyl ketone (MEK) was as effective. In addition, in situ-generated α-bromo-δ-valerolactone was directly converted into a sulfur-substituted functional lactone without difficulty by reacting it with a sulfur nucleophile in one pot without isolation. This new bromination system is expected to facilitate the industrial use of α-bromolactones as important intermediates.

    DOI: 10.3762/bjoc.17.198

    Other URL: https://www.beilstein-journals.org/bjoc/content/pdf/1860-5397-17-198.pdf

  • Excellent Catalytic Performances of a Au/C–CuO Binary System in the Selective Oxidation of Benzylamines to Imines under Atmospheric Oxygen

    Yuki Yamamoto, Miyuto Ota, Shintaro Kodama, Michio Ueshima, Akihiro Nomoto, Akiya Ogawa, Mitsunori Furuya, Kiminori Kawakami

    ACS Omega   2021.12( ISSN:2470-1343

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/acsomega.1c04046

  • Uniaxially Oriented Electrically Conductive Metal–Organic Framework Nanosheets Assembled at Air/Liquid Interfaces

    Takashi Ohata, Akihiro Nomoto, Takeshi Watanabe, Ichiro Hirosawa, Tatsuyuki Makita, Jun Takeya, Rie Makiura

    ACS Applied Materials &amp; Interfaces   13 ( 45 )   54570 - 54578   2021.11( ISSN:1944-8244

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/acsami.1c16180

  • trans-Bis[8-(benzylsulfanyl)quinoline-κ2 N,S]dichloridocobalt(II) Reviewed

    Shintaro Kodama, Kazuki Bunno, Akihiro Nomoto, Akiya Ogawa

    IUCrData   2021.10

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1107/S2414314621009925

  • Uniaxially Oriented Electrically Conductive Metal-Organic Framework Nanosheets Assembled at Air/Liquid Interfaces Reviewed

    Ohata, Takashi; Nomoto, Akihiro; Watanabe, Takeshi; Hirosawa, Ichiro; Makita, Tatsuyuki; Takeya, Jun; Makiura, Rie

    ACS Applied Materials & Interfaces 雑誌   13 ( 45 )   2021.10

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    Kind of work:Joint Work  

  • trans-Bis[8-(benzylsulfanyl)quinoline-κ2 N,S]dichloridocobalt(II) Reviewed

    Shintaro Kodama, Kazuki Bunno, Akihiro Nomotoa, Akiya Ogawa

    IUCrData 雑誌   6 ( 10 )   2021.10

  • Clarification on the Reactivity of Diaryl Diselenides toward Hexacyclohexyldilead under Light Reviewed

    Vu Thai Hung, Cong Chi Tran, Yuki Yamamoto, Shintaro Kodama, Akihiro nomoto, Akiya Ogawa

    Molecules   2021.10

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.3390/molecules26206265

  • 2,2-Bis(phenylselanyl)-1-(p-tolyl)vinyl 2-Oxo-2-(p-tolyl)acetate

    Shintaro Kodama, Vu Thai Hung, Tomokazu Saeki, Kei Mihara, Yuki Yamamoto, Motohiro Sonoda, Akihiro Nomoto, Akiya Ogawa

    Molbank   2021 ( 4 )   M1283 - M1283   2021.09

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    Publishing type:Research paper (scientific journal)  

    2,2-Bis(phenylselanyl)-1-(p-tolyl)vinyl 2-oxo-2-(p-tolyl)acetate was synthesized via the reaction of p-tolylacetylene with diphenyl diselenide and benzoyl peroxide in benzene under atmospheric conditions. The molecular structure of the synthesized compound was evaluated using single-crystal X-ray analysis and spectral analyses. The process reported here provides a rare example of the direct and selective transformation of a terminal alkyne to the corresponding geminal diseleno-substituted alkene.

    DOI: 10.3390/m1283

  • 2,2-Bis(phenylselanyl)-1-(p-tolyl)vinyl 2-Oxo-2-(p-tolyl)acetate Reviewed

    Shintaro Kodama, Vu Thai Hung, Tomokazu Saeki, Kei Mihara, Yuki Yamamoto, Motohiro Sonoda, Akihiro Nomoto, Akiya Ogawa

    Molbank   2021   2021.09

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    Kind of work:Joint Work  

  • Long-term clinical outcomes after 12-fractionated carbon-ion radiotherapy for localized prostate cancer.

    Sato H, Kasuya G, Ishikawa H, Nomoto A, Ono T, Nakajima M, Isozaki Y, Yamamoto N, Iwai Y, Nemoto K, Ichikawa T, Tsuji H, Working Group for Genitourinary Tumors.

    Cancer science   112 ( 9 )   3598 - 3606   2021.09( ISSN:1347-9032

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  • Oxidative Synthesis of Acid Blue 7 Dye Catalyzed by CuO/Silicotungstic Acid in Water-Phase

    Akihiro Nomoto, Tomoya Okada, Yuki Yamamoto, Shota Kuroda, Kuniaki Marui, Mika Yamamoto, Hidetaka Tsujimoto, Michio Ueshima, Tamotsu Nishigahana, Keiji Itoh, Gohei Kobata, Shintaro Kodama, Akiya Ogawa

    Materials   14 ( 16 )   4505 - 4505   2021.08

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    Publishing type:Research paper (scientific journal)  

    A catalytic oxidation reaction for Acid Blue 7 dye synthesis was evaluated in water. Without lead oxide or manganese oxide derivatives as oxidants, polyoxometalate catalysts were investigated to reduce the usage of harmful heavy metal. A catalyst was prepared by mixing silicotungstic acid with copper oxide, and aqueous hydrogen peroxide (30%) was used as an oxidizing agent. This reaction proceeded to produce Acid Blue 7 from the corresponding leuco acid after 45 min at 95 °C and was viable for a 10 g-scale synthesis.

    DOI: 10.3390/ma14164505

  • Transition-Metal-Catalyzed Diarylation of Isocyanides with Triarylbismuthines for the Selective Synthesis of Imine Derivatives

    Shintaro Kodama, Yuki Yamamoto, Yohsuke Kobiki, Hitomi Matsubara, Cong Chi Tran, Shin-ichi Kawaguchi, Akihiro Nomoto, Akiya Ogawa

    Materials   14 ( 15 )   4271 - 4271   2021.07

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    Publishing type:Research paper (scientific journal)  

    The transition-metal-catalyzed diarylation of isocyanides with triarylbismuthines was investigated in detail, and rhodium catalysts such as [RhCl(nbd)]2 were found to selectively afford N-alkyl diaryl ketimines. On the other hand, palladium-catalyzed diarylation proceeded with the incorporation of two molecules of isocyanide, preferentially yielding N,N’-dialkyl or N,N’-diaryl α-diimines. In addition, a cascade synthesis of 2,3-diarylquinoxalines starting from the palladium-catalyzed diarylation of isocyanides with triarylbismuthines was successfully achieved.

    DOI: 10.3390/ma14154271

  • One-Pot Construction of Diverse β-Lactam Scaffolds via the Green Oxidation of Amines and Its Application to the Diastereoselective Synthesis of β-Amino Acids

    Yuki Yamamoto, Shintaro Kodama, Riku Nishimura, Akihiro Nomoto, Michio Ueshima, Akiya Ogawa

    The Journal of Organic Chemistry   2021.07( ISSN:0022-3263

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    DOI: 10.1021/acs.joc.1c01128

  • 4,4′-Di-tert-butyl-2,2′-bipyridinium Trifluoromethanesulfonate Reviewed

    Shintaro Kodama, Kazuki Bunno, Akihiro Nomoto, Akiya Ogawa

    Molbank   2021 ( 3 )   2021.07

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    DOI: 10.3390/M1261

  • 4,4′-Di-tert-butyl-2,2′-bipyridinium Trifluoromethanesulfonate Reviewed

    Shintaro Kodama, Kazuki Bunno, Akihiro Nomoto, Akiya Ogawa

    Molbank   2021   2021.07

  • Carbon-ion radiotherapy for octogenarians with locally advanced non-small-cell lung cancer.

    Hayashi K, Yamamoto N, Nakajima M, Nomoto A, Ishikawa H, Ogawa K, Tsuji H

    Japanese journal of radiology   39 ( 7 )   703 - 709   2021.07( ISSN:1867-1071

  • Highly regio- and stereoselective phosphinylphosphination of terminal alkynes with tetraphenyldiphosphine monoxide under radical conditions

    Dat Phuc Tran, Yuki Sato, Yuki Yamamoto, Shin-ichi Kawaguchi, Shintaro Kodama, Akihiro Nomoto, Akiya Ogawa

    Beilstein Journal of Organic Chemistry   17   866 - 872   2021.04

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    The homolytic cleavage of the P<sup>V</sup>(O)–P<sup>III</sup> bond in tetraphenyldiphosphine monoxide simultaneously provides both pentavalent and trivalent phosphorus-centered radicals with different reactivities. The method using V-40 as an initiator is successfully investigated for the regio- and stereoselective phosphinylphosphination of terminal alkynes giving the corresponding <italic>trans</italic>-isomers of 1-diphenylphosphinyl-2-diphenylthiophosphinyl-1-alkenes in good yields. The protocol can be applied to a wide variety of terminal alkynes including both alkyl- and arylalkynes.

    DOI: 10.3762/bjoc.17.72

    Other URL: https://www.beilstein-journals.org/bjoc/content/pdf/1860-5397-17-72.pdf

  • Photoinduced selective hydrophosphinylation of allylic compounds with diphenylphosphine oxide leading to γ-functionalized P-ligand precursors

    Dat Phuc Tran, Yuki Sato, Yuki Yamamoto, Shin-ichi Kawaguchi, Shintaro Kodama, Akihiro Nomoto, Akiya Ogawa

    Research on Chemical Intermediates   2021.04( ISSN:0922-6168

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    DOI: 10.1007/s11164-021-04433-7

    Other URL: http://link.springer.com/article/10.1007/s11164-021-04433-7/fulltext.html

  • Photoinduced selective hydrophosphinylation of allylic compounds with diphenylphosphine oxide leading to b-functionalized P-ligand precursors. Reviewed

    Tran, Phuc Dat; Sato, Yuki; Yamamoto, Yuki; Kawaguchi, Shin-ichi; Kodama, Shintaro; Nomoto, Akihiro; Ogawa, Akiya

    Res. Chem. Intermed. 雑誌 Elsevier   47 ( 7 )   2021.04

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  • Maltotriose–Chlorin e6 Conjugate Linked via Tetraethyleneglycol as an Advanced Photosensitizer for Photodynamic Therapy. Synthesis and Antitumor Activities against Canine and Mouse Mammary Carcinoma Cells

    Atsushi Narumi, Rioko Rachi, Hiromi Yamazaki, Seigou Kawaguchi, Moriya Kikuchi, Hiroyuki Konno, Tomohiro Osaki, Yoshiharu Okamoto, Xiande Shen, Toyoji Kakuchi, Hiromi Kataoka, Akihiro Nomoto, Tomokazu Yoshimura, Shigenobu Yano

    ACS Omega   6 ( 10 )   7023 - 7033   2021.03( ISSN:2470-1343

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    DOI: 10.1021/acsomega.0c06316

  • Large-Scale Synthesis of Thio-Glucose-Conjugated Chlorin E6 for Photodynamic Therapy Reviewed

    Nomoto, Akihiro; Yamaguchi, Hiroaki; Masuda, Masato; Hyakumura, Keisuke; Kodama, Shintaro; Osaki, Tomohiro; Okamoto, Yoshiharu; Tanaka, Mamoru; Kataoka, Hiromi; Narumi, Atsushi; Yoshimura, Tomokazu; Yano, Shigenobu; Ogawa, Akiya

    Heterocycles 雑誌 Heterocycles   103 ( 2 )   2021.03

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  • Sulfur-Promoted Redox Cyclization of 2,2′-Dinitrodiphenyl Disulfides and Benzylamines Reviewed

    Teramoto, Masahiro; Imoto, Mitsutaka; Takeda, Motonori; Mizuno, Takumi; Nomoto, Akihiro; Ogawa, Akiya

    Synthesis 雑誌 Thime   asap   2021.03

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  • Potential of Photodynamic Therapy Based on Sugar-Conjugated Photosensitizers

    Hiromi Kataoka, Hirotada Nishie, Mamoru Tanaka, Makiko Sasaki, Akihiro Nomoto, Tomohiro Osaki, Yoshiharu Okamoto, Shigenobu Yano

    Journal of Clinical Medicine   10 ( 4 )   841 - 841   2021.02

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    In 2015, the Japanese health insurance approved the use of a second-generation photodynamic therapy (PDT) using talaporfin sodium (TS); however, its cancer cell selectivity and antitumor effects of TS PDT are not comprehensive. The Warburg effect describes the elevated rate of glycolysis in cancer cells, despite the presence of sufficient oxygen. Because cancer cells absorb considerable amounts of glucose, they are visible using positron emission tomography (PET). We developed a third-generation PDT based on the Warburg effect by synthesizing novel photosensitizers (PSs) in the form of sugar-conjugated chlorins. Glucose-conjugated (tetrafluorophenyl) chlorin (G-chlorin) PDT revealed significantly stronger antitumor effects than TS PDT and induced immunogenic cell death (ICD). ICD induced by PDT enhances cancer immunity, and a combination therapy of PDT and immune checkpoint blockers is expected to synergize antitumor effects. Mannose-conjugated (tetrafluorophenyl) chlorin (M-chlorin) PDT, which targets cancer cells and tumor-associated macrophages (TAMs), also shows strong antitumor effects. Finally, we synthesized a glucose-conjugated chlorin e6 (SC-N003HP) that showed 10,000–50,000 times stronger antitumor effects than TS (IC50) in vitro, and it was rapidly metabolized and excreted. In this review, we discuss the potential and the future of next-generation cancer cell-selective PDT and describe three types of sugar-conjugated PSs expected to be clinically developed in the future.

    DOI: 10.3390/jcm10040841

  • Photodynamic therapy exploiting the anti-tumor activity of mannose-conjugated chlorin e6 reduced M2-like tumor-associated macrophages

    Tatsuki Soyama, Akira Sakuragi, Daisuke Oishi, Yuka Kimura, Hiromasa Aoki, Akihiro Nomoto, Shigenobu Yano, Hirotada Nishie, Hiromi Kataoka, Mineyoshi Aoyama

    Translational Oncology   14 ( 2 )   101005 - 101005   2021.02( ISSN:1936-5233

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    DOI: 10.1016/j.tranon.2020.101005

  • Large-scale synthesis of thio-glucose-conjugated chlorin E6 for photodynamic therapy

    Akihiro Nomoto, Hiroaki Yamaguchi, Masato Masuda, Keisuke Hyakumura, Shintaro Kodama, Tomohiro Osaki, Yoshiharu Okamoto, Mamoru Tanaka, Hiromi Kataoka, Atsushi Narumi, Tomokazu Yoshimura, Shigenobu Yano, Akiya Ogawa

    Heterocycles   103 ( 2 )   2021( ISSN:0385-5414

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    Chlorin e6 is a heterocycle exhibiting spectral absorption in the 600-700 nm wavelength range used for photodynamic therapy (PDT). Herein, a sugar-conjugated chlorin e6 derivative was synthesized on a large scale. An alkyl spacer was fabricated by controlling the alkoxylation conditions between the thio-sugar and chlorin e6 and thio-glucose-conjugated chlorin e6 was successfully synthesized.

    DOI: 10.3987/COM-20-S(K)73

  • Long Term Results of Single-Fraction Carbon-Ion Radiotherapy for Non-small Cell Lung Cancer.

    Ono T, Yamamoto N, Nomoto A, Nakajima M, Isozaki Y, Kasuya G, Ishikawa H, Nemoto K, Tsuji H

    Cancers   13 ( 1 )   2020.12

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  • Au/Ag/Cu-Mixed Catalysts for the Eco-Friendly Oxidation of 5-Hydroxymethylfurfural and Related Compounds to Carboxylic Acids under Atmospheric Oxygen in Water

    Yuki Yamamoto, Miyuto Ota, Shintaro Kodama, Kazuki Michimoto, Akihiro Nomoto, Akiya Ogawa, Mitsunori Furuya, Kiminori Kawakami

    ACS Omega   2020.12( ISSN:2470-1343

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/acsomega.0c05526

  • Transition-Metal-Free Synthesis of 2-Substituted Benzothiazoles from Nitrobenzenes, Methylheteroaryl Compounds, and Elemental Sulfur, Based on Nitro-Methyl Redox-Neutral Cyclization.

    Teramoto M, Imoto M, Takeda M, Mizuno T, Nomoto A, Ogawa A

    The Journal of organic chemistry   85 ( 23 )   15213 - 15220   2020.12( ISSN:0022-3263

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  • Phosphorus-Recycling Wittig Reaction: Design and Facile Synthesis of a Fluorous Phosphine and Its Reusable Process in the Wittig Reaction

    Yuki Yamamoto, Shin-ichi Kawaguchi, Misaki Nishimura, Yuki Sato, Yoshihisa Shimada, Akihiro Tabuchi, Akihiro Nomoto, Akiya Ogawa

    The Journal of Organic Chemistry   2020.11( ISSN:0022-3263

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/acs.joc.0c01926

  • Photoinduced Syntheses and Reactivities of Phosphorus-Containing Interelement Compounds

    Yuki Yamamoto, Ryo Tanaka, Miyuto Ota, Misaki Nishimura, Cong Chi Tran, Shin-ichi Kawaguchi, Shintaro Kodama, Akihiro Nomoto, Akiya Ogawa

    The Journal of Organic Chemistry   2020.10( ISSN:0022-3263

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/acs.joc.0c02014

  • Novel Photosensitizer β-Mannose-Conjugated Chlorin e6 as a Potent Anticancer Agent for Human Glioblastoma U251 Cells

    Yo Shinoda, Kohei Kujirai, Kohei Aoki, Mai Morita, Masato Masuda, Lihao Zhang, Zhou Kaixin, Akihiro Nomoto, Tsutomu Takahashi, Yayoi Tsuneoka, Jiro Akimoto, Hiromi Kataoka, Rioko Rachi, Atsushi Narumi, Tomokazu Yoshimura, Shigenobu Yano, Yasuyuki Fujiwara

    Pharmaceuticals   13 ( 10 )   316 - 316   2020.10

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    A photosensitizer is a molecular drug for photodynamic diagnosis and photodynamic therapy (PDT) against cancer. Many studies have developed photosensitizers, but improvements in their cost, efficacy, and side effects are needed for better PDT of patients. In the present study, we developed a novel photosensitizer β-mannose-conjugated chlorin e6 (β-M-Ce6) and investigated its PDT effects in human glioblastoma U251 cells. U251 cells were incubated with β-M-Ce6, followed by laser irradiation. Cell viability was determined using the Cell Counting Kit-8 assay. The PDT effects of β-M-Ce6 were compared with those of talaporfin sodium (TS) and our previously reported photosensitizer β-glucose-conjugated chlorin e6 (β-G-Ce6). Cellular uptake of each photosensitizer and subcellular distribution were analyzed by fluorescence microscopy. β-M-Ce6 showed 1000× more potent PDT effects than those of TS, and these were similar to those of β-G-Ce6. β-M-Ce6 accumulation in U251 cells was much faster than TS accumulation and distributed to several organelles such as the Golgi apparatus, mitochondria, and lysosomes. This rapid cellular uptake was inhibited by low temperature, which suggested that β-M-Ce6 uptake uses biological machinery. β-M-Ce6 showed potent PDT anti-cancer effects compared with clinically approved TS, which is a possible candidate as a next generation photosensitizer in cancer therapy.

    DOI: 10.3390/ph13100316

  • 糖連結光感受性物質による癌細胞超選択的光線力学療法の開発

    田中 守・西江 裕忠・片岡 洋望・野元 昭宏・矢野 重信

    光アライアンス 雑誌 光アライアンス   31 ( 8 )   1 - 4   2020.08

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  • Metal- and base-free synthesis of aryl bromides from arylhydrazines Reviewed

    Phuc Tran, Dat; Nomoto, Akihiro; Mita, Soichiro; Dong, Chun-ping; Kodama, Shintaro; Mizuno, Takumi; Ogawa, Akiya

    Tetrahedron Lett. 雑誌 Elsevier   61 ( 23 )   2020.06

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  • Development of environmentally friendly catalytic liquid-phase oxidation reaction and application of organic catalysts

    Peterotech   43 ( 10 )   697 - 702   2020.06

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  • Tris(4,4′-di-tert-butyl-2,2′-bipyridine)(trans-4-tert-butylcyclohexanolato)deca-μ-oxido-heptaoxidoheptavanadium acetonitrile monosolvate including another unknown solvent molecule Reviewed

    Shintaro Kodama, Shota Kondo, Akihiro Nomoto, Akiya Ogawa

    IUCrData   5 ( 4 )   2020.04

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1107/S2414314620004496

  • Tris(4,4'-di-tert-butyl-2,2'-bipyridine)(trans-4-tert-butylcyclohexanolato)deca-μ-oxido-heptaoxidoheptavanadium acetonitrile monosolvate including another unknown solvent molecule Reviewed

    Kodama, Shintaro; Kondo, Shota; Nomoto, Akihiro; Ogawa, Akiya

    IUCrData 雑誌 IUCr   5 ( 4 )   2020.04

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  • Photoinduced Cyclizations of o-Diisocyanoarenes with Organic Diselenides and Thiols that Afford Chalcogenated Quinoxalines Reviewed

    Tran Cong Chi; Sato Fumiya; Nomoto Akihiro; Ogawa Akiya; Kawaguchi Shin-Ichi

    The Journal of organic chemistry 雑誌 ACS   85 ( 11 )   7258 - 7266   2020.04

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  • Metal- and base-free synthesis of aryl bromides from arylhydrazines Reviewed

    Dat Phuc Tran, Akihiro Nomoto, Soichiro Mita, Chun-ping Dong, Shintaro Kodama, Takumi Mizuno, Akiya Ogawa

    Tetrahedron Letters   151959 - 151959   2020.04

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    DOI: 10.1016/j.tetlet.2020.151959

  • Photoinduced Cyclizations of o-Diisocyanoarenes with Organic Diselenides and Thiols that Afford Chalcogenated Quinoxalines Reviewed

    Tran Cong Chi, Sato Fumiya, Nomoto Akihiro, Ogawa Akiya, Kawaguchi Shin-Ichi

    The Journal of organic chemistry   85 ( 11 )   7258 - 7266   2020.04

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  • Highly Selective Hydroiodination of Carbon–Carbon Double or Triple Bonds

    Yuki Yamamoto, Shin-ichi Kawaguchi, Shintaro Kodama, Akihiro Nomoto, Akiya Ogawa

    Current Organic Chemistry   24   2019.12( ISSN:1385-2728

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    <sec>
    <title>:</title>
    Iodine is an element that exhibits characteristic features of heavy halogen, and several compounds containing iodine constitute important synthetic intermediates due to synthetically easy manipulation. To utilize iodine units for organic synthesis, a highly regio- and stereoselective introduction of iodine to versatile building blocks is significant, and a lot of researches for the selective introduction of iodine to alkynes or alkenes have been investigated. In this review article, we describe regio- and stereoselective hydroiodination to multiple bonds of building blocks, and its synthetic applications as key intermediates to construct several important compounds in organic chemistry.


    </sec>

    DOI: 10.2174/1385272824666191227111257

  • Palladium-Catalyzed Diarylation of Isocyanides with Tetraarylleads for the Selective Synthesis of Imines and α-Diimines.

    Tran CC, Kawaguchi SI, Kobiki Y, Matsubara H, Tran DP, Kodama S, Nomoto A, Ogawa A

    The Journal of organic chemistry   84 ( 18 )   11741 - 11751   2019.09( ISSN:0022-3263

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  • 2,4,6-Trihydroxybenzoic Acid-Catalyzed Oxidative Ugi Reactions with Molecular Oxygen via Homo- and Cross- Coupling of Amines Reviewed

    Chun-ping Dong, Akinori Uematsu, Shun Kumazawa, Yuki Yamamoto, Shintaro Kodama, Akihiro Nomoto, Michio Ueshima, Akiya Ogawa

    J. Org. Chem.   84 ( 18 )   11562 - 11571   2019.08

  • Antitumor Effect of a Novel Photodynamic Therapy With Acetylated Glucose-conjugated Chlorin for Gastrointestinal Cancers. Reviewed

    Hiroshi Ichikawa, Hirotada Nishie, Shigenobu Yano, Yuki Komai, Hiroaki Yamaguchi, Akihiro Nomoto, Taketo Suzuki, Mamoru Tanaka, Takaya Shimura, Tsutomu Mizoshita, Eiji Kubota, Satoshi Tanida, Hiromi Kataoka

    Anticancer research   39 ( 8 )   4199 - 4206   2019.08

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    Publishing type:Research paper (scientific journal)   International / domestic magazine:International journal  

    BACKGROUND/AIM: We previously synthesized a glucose-conjugated chlorin compound e6 (G-chlorin e6), and reported that it has very strong antitumor effects. The aim of the present study was to synthesize acetylated glucose-conjugated chlorin (AcN003HP) and evaluate its antitumor effect and excretion. MATERIALS AND METHODS: To evaluate the antitumor effect of AcN003HP, its IC50 was calculated as well as its accumulation in cancer cells was examined by flow cytometry. Confocal microscopy was used to observe the intracellular localization of AcN003HP. The excretion and antitumor effects of AcN003HP were also evaluated in vivo. RESULTS: AcN003HP showed stronger antitumor effects and accumulation into cancer cells compared to talaporfin sodium, a conventional photosensitizer. AcN003HP was localized in the endoplasmic reticulum. In a xenograft tumor mouse model, AcN003HP showed longer excretion time from the body than G-chlorin e6, and photodynamic therapy using AcN003HP showed very strong antitumor effects. CONCLUSION: The safety, improved controllability, and robust antitumor effects suggest AcN003HP as a good next-generation photosensitizer.

    DOI: 10.21873/anticanres.13580

    PubMed

  • Palladium-Catalyzed Diarylation of Isocyanides with Tetraarylleads for the Selective Synthesis of Imines and α-Diimines Reviewed

    Cong Chi Tran, Shin-ichi Kawaguch, Yohsuke Kobiki, Hitomi Matsubara, Dat Phuc Tran, Shintaro Kodama, Akihiro Nomoto, Akiya Ogawa

    J. Org. Chem.   84 ( 18 )   11741 - 11751   2019.08

  • C60 Fullerene with Tetraethylene Glycols as a Well-defined Soluble Building Block and Saccharide-conjugation Producing PDT Photosensitizer. Reviewed

    A. Narumi, T. Nakazawa, K. Shinohara, H. Kato, Y. Iwaki, H. Okimoto, M. Kikuchi, S. Kawaguchi, S. Hino, A. Ikeda, M. S. A. Shaykoon, X. Shen, Q. Duan, T. Kakuchi, K. Yasuhara, A. Nomoto, Y. Mikata and S. Yano

    Chemistry Letters 雑誌 CSJ   48 ( 10 )   1209 - 1212   2019.07

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  • 4,6-Dihydroxysalicylic Acid-Catalyzed Oxidative Condensation of Benzylic Amines and Aromatic Ketones for the Preparation of 2,4,6-Trisubstituted Pyridines and Its Application to Metal-Free Synthesis of G-Quadruplex Binding Ligands.

    Dong CP, Kodama S, Nomoto A, Ueshima M, Ogawa A

    ACS omega   4 ( 5 )   9029 - 9040   2019.05

  • Reductive Rearrangement of Tetraphenyldiphosphine Disulfide To Trigger the Bisthiophosphinylation of Alkenes and Alkynes.

    Sato Y, Nishimura M, Kawaguchi SI, Nomoto A, Ogawa A

    Chemistry (Weinheim an der Bergstrasse, Germany)   25 ( 27 )   6797 - 6806   2019.05( ISSN:0947-6539

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  • 4,6-Dihydroxysalicylic Preparation of 2,4,6-Trisubstituted Acid-Catalyzed Pyridines Oxidative and Condensation Its Application of Benzylic to Metal-Free Amines Synthesis and Aromatic of G-Quadruplex Ketones for Binding Ligands Reviewed

    Dong Chun-Ping; Kodama Shintaro; Nomoto Akihiro; Ueshima Michio; Ogawa Akiya

    ACS Omega 雑誌 ACS   2019.05

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  • A basic study of photodynamic therapy with glucose-conjugated chlorin e6 using mammary carcinoma xenografts Reviewed

    Tomohiro Osaki, Shota Hibino, Inoru Yokoe, Hiroaki Yamaguchi, Akihiro Nomoto, Shigenobu Yano, Yuji Mikata, Mamoru Tanaka, Hiromi Kataoka, Yoshiharu Okamoto

    Cancers   11 ( 5 )   636   2019.05

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    © 2019, MDPI AG. All rights reserved. By using the Warburg effect-a phenomenon where tumors consume higher glucose levels than normal cells-on cancer cells to enhance the effect of photodynamic therapy (PDT), we developed a new photosensitizer, glucose-conjugated chlorin e6 (G-Ce6). We analyzed the efficacy of PDT with G-Ce6 against canine mammary carcinoma (CMC) in vitro and in vivo. The pharmacokinetics of G-Ce6 at 2, 5, and 20 mg/kg was examined in normal dogs, whereas its intracellular localization, concentration, and photodynamic effects were investigated in vitro using CMC cells (SNP cells). G-Ce6 (10 mg/kg) was administered in vivo at 5 min or 3 h before laser irradiation to SNP tumor-bearing murine models. The in vitro study revealed that G-Ce6 was mainly localized to the lysosomes. Cell viability decreased in a G-Ce6 concentration- and light intensity-dependent manner in the PDT group. Cell death induced by PDT with G-Ce6 was not inhibited by an apoptosis inhibitor. In the in vivo study, 5-min-interval PDT exhibited greater effects than 3-h-interval PDT. The mean maximum blood concentration and half-life of G-Ce6 (2 mg/kg) were 15.19 ± 4.44 µg/mL and 3.02 ± 0.58 h, respectively. Thus, 5-min-interval PDT with G-Ce6 was considered effective against CMC.

    DOI: 10.3390/cancers11050636

  • the 4,6-Dihydroxysalicylic Preparation of 2,4,6-Trisubstituted Acid-Catalyzed Pyridines Oxidative and Condensation Its Application of Benzylic to Metal-Free Amines Synthesis and Aromatic of G-Quadruplex Ketones for Binding Ligands Reviewed

    Dong Chun-Ping, Kodama Shintaro, Nomoto Akihiro, Ueshima Michio, Ogawa Akiya

    ACS Omega   4 ( 5 )   9029 - 9040   2019.05

  • Synthesis and crystal structures of phenylalanine ester-introduced palladium(II) and platinum(II) complexes and their cytotoxicities Reviewed

    A. Nomoto, N. Sakamoto, Y. Sakai, K. Fukumoto, S. Ogura, S. Katao, K. Kakiuchi, J. Kikuchi, S. Yano, A. Ogawa

    Research on Chemical Intermediates   49   3 - 12   2019.04

  • Risk of subsequent primary cancers after carbon ion radiotherapy, photon radiotherapy, or surgery for localised prostate cancer: a propensity score-weighted, retrospective, cohort study Reviewed

    Mohamad Osama; Tabuchi Takahiro; Sato Akira; Morishima Toshitaka; Nitta Yuki; Nomoto Akihiro; Kasuya Goro; Yamada Shigeru; Tsuji Hiroshi; Makishima Hirokazu; et al

    The Lancet. Oncology 雑誌 NCBI   20 ( 5 )   674 - 685   2019.03

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  • Reductive Rearrangement of Tetraphenyldiphosphine Disulfide To Trigger the Bisthiophosphinylation of Alkenes and Alkynes Reviewed

    Yuki, Sato, Misaki, Nishimura, Shin‐ich,i Kawaguch, Akihiro, Nomoto, Akiya, Ogawa

    Eur. J. Org. Chem.   25 ( 7 )   6797 - 6806   2019.03

  • Synthesis of Bis(phosphanyl)alkane Monosulfides by the Addition of Diphosphane Monosulfides to Alkenes under Light.

    Sato Y, Kawaguchi SI, Nomoto A, Ogawa A

    Chemistry (Weinheim an der Bergstrasse, Germany)   25 ( 9 )   2295 - 2302   2019.02( ISSN:0947-6539

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  • Reaction of Arylhydrazines with Diaryl Ditellurides in the Air: Insight into Bimolecular Homolytic Substitution on Tellurium via Aryl-Te Bond Cleavage Reviewed

    Y. Yamamoto, F. Sato, S. Kodama, A. Nomoto, A. Ogawa

    Heteroatom Chemistry   29   e21471 - e21471   2019.01

  • C<inf>60</inf> Fullerene with Tetraethylene Glycols as a Well-defined Soluble Building Block and Saccharide-conjugation Producing PDT Photosensitizer Reviewed

    Atsushi Narumi, Tatsufumi Nakazawa, Kosuke Shinohara, Hiroki Kato, Yoshinori Iwaki, Haruya Okimoto, Moriya Kikuchi, Seigou Kawaguchi, Shodai Hino, Atsushi Ikeda, Montaser Shaykoon Ahmed Shaykoon, Xiande Shen, Qian Duan, Toyoji Kakuchi, Kazuma Yasuhara, Akihiro Nomoto, Yuji Mikata, Shigenobu Yano

    Chemistry Letters   48 ( 10 )   1209 - 1211   2019( ISSN:0366-7022

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    © 2019 The Chemical Society of Japan. Tetraethylene glycol (TEG)-conjugated (C60-Ih)[5,6]fullerene (TEG-C60) was synthesized as a soluble molecular building block generating C60-based conjugates with advanced properties. The improved solubility allowed the glycosylation reaction with TEG-C60 using a Lewis acid in chloroform at low temperature. The resultant glycoconjugated TEG-C60 was characterized in terms of water solubility, ability to generate reactive oxygen species (ROS), and photodynamic activity.

    DOI: 10.1246/cl.190492

  • Synthesis of Aryl Iodides from Arylhydrazines and Iodine Reviewed

    C.-p. Dong, K. Nakamura, T. Taniguchi, S. Mita, S. Kodama, S.-i. Kawaguchi, A. Nomoto, A. Ogawa, T. Mizuno

    ACS Omega 雑誌 ACS   3   9814 - 9821   2018.08

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  • Palladium-Catalyzed Cyanothiolation of Internal Alkynes Using Organic Disulfides and tert-Butyl Isocyanide Reviewed

    S. Higashimae, D. Kurata, S.-i. Kawaguchi, S. Kodama, M. Sonoda, A. Nomoto and A. Ogawa

    J. Org. Chem. 雑誌 ACS   83   5267 - 5273   2018.04

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  • Metal-Free Synthesis of N-Containing Heterocycles from o-Substituted Aniline Derivatives via 2,4,6-Trihydroxybenzoic Acid-Catalyzed Oxidative Dehydrogenation of Benzylamines under Oxygen Atmosphere Reviewed

    Shun Kumazawa, Akinori Uematsu, Chun-ping Dong, Shintaro Kodama, Akihiro Nomoto, Michio Ueshima, and Akiya Ogawa*

    Heterocycles 雑誌 The Japan Institute of Heterocyclic Chemistry   97   842 - 853   2018.04

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    Kind of work:Joint Work  

  • Excellent antitumor effects for gastrointestinal cancers using photodynamic therapy with a novel glucose conjugated chlorin e6 Reviewed

    H. Nishie, H. Kataoka, S. Yano, H. Yamaguchi, A. Nomoto, M. Tanaka, A. Kato, T. Shimura, T. Mizoshita, E. Kubota, S. Tanida, T. Joh

    Biochem. Biophys. Res. Commun. 雑誌 NCBI   4   1204 - 1209   2018.01

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  • Synthesis and characterization of a biphenyl-linked hemicryptophane and an endohedral cobalt (II) complex Reviewed

    Y. Makita, T. Danno, K. Ikeda, H. Lee, T. Abe, K. Sogawa, A. Nomoto, S. Fujiwara, A. Ogawa

    Tetrahedron Lett. 雑誌 Elsevier   58   4507 - 4509   2017.11

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  • Metal-Free Blue Dye Synthesis: Oxidative Coupling of Benzylamines and N,N-Dimethylanilines to Yield 4,4′-Diaminotriarylmethanes in the Presence of Salicylic Acid as a Co-oxidant Reviewed

    C-p. Dong, S. Kodama, A. Uematsu, A. Nomoto, M. Ueshima, A. Ogawa

    J. Org. Chem. 雑誌 NCBI   82   12530 - 12538   2017.11

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  • A Benzoyl Peroxide/Diphenyl Diselenide Binary System for Functionalization of Alkynes Leading to Alkenyl and Alkynyl Selenides Reviewed

    S. Kodama, T. Saeki, K. Mihara, S. Higashimae, S. Kawaguchi, M. Sonoda, A. Nomoto, A. Ogawa

    J. Org. Chem. 雑誌 ACS   82   12477 - 12484   2017.11

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  • Photoinduced Coupling Reaction of Diphenyl(2,4,6-trimethylbenzoyl)phosphine Oxide with Interelement Compounds: Application to the Synthesis of Thio- or Selenophosphinates Reviewed

    Y. Sato, S-i. Kawaguchi, A. Nomoto, A. Ogawa

    Synthesis 雑誌 Thieme   49   3558 - 3567   2017.07

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  • Atom-Economical Synthesis of Unsymmetrical Diaryl Selenides from Arylhydrazines and Diaryl Diselenides Reviewed

    T. Taniguchi, A. Murata, M. Takeda, T. Mizuno, A. Nomoto, A. Ogawa

    Eur. J. Org. Chem. 雑誌 Wiley   2017   4928 - 4934   2017.07

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  • Hydroiodination-Triggered Cascade Reaction with I2/PPh3/H2O: a Metal-Free Access to 3-Substituted Phthalides from 2-Alkynylbenzoates Reviewed

    S-i. Kawaguchi, K. Nakamura, K. Yamaguchi, Y. Sato, Y. Gonda, M. Nishioka, M. Sonoda, A. Nomoto, A. Ogawa

    Eur. J. Org. Chem. 雑誌 Wiley   2017   5343 - 5346   2017.06

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  • Transition-Metal-Free and Oxidant-Free Cross-Coupling of Arylhydrazines with Disulfides: Base-Promoted Synthesis of Unsymmetrical Aryl Sulfides Reviewed

    T. Taniguchi, T. Naka, M. Imoto, M. Takeda, F. Matsumoto, T. Nakai, M. Mihara, T. Mizuno, A. Nomoto, A. Ogawa

    J. Org. Chem. 雑誌 ACS   82   6647 - 6655   2017.06

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  • Maltotriose Conjugation to a Chlorin Derivative Enhances the Antitumor Effects of Photodynamic Therapy in Peritoneal Dissemination of Pancreatic Cancer Reviewed

    A. Kato, H. Kataoka, S. Yano, K. Hayashi, N. Hayashi, M. Tanaka, I. Naitoh, T. Ban, K. Miyabe, H. Kondo, M. Yoshida, Y. Fujita, Y. Hori, M. Natsume, T. Murakami, A. Narumi, A. Nomoto, A. Naiki-Ito, S. Takahashi, and T. Joh

    Mol. Cancer Ther 雑誌 AACR   16   2017.03

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  • P-Fluorous Phosphines as Electron-Poor/Fluorous Hybrid Functional Ligands for Precious Metal Catalysts: Synthesis of Rh(I), Ir(I), Pt(II), and Au(I) Complexes Bearing P-Fluorous Phosphine Ligands Reviewed

    S.-i. Kawaguchi, Y. Saga, Y. Sato, Y. Minamida, A. Nomoto and A. Ogawa

    Inorganics 雑誌 MDPI   5 ( 5 )   1 - 10   2017.01

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  • Regioselective Radical Arylation of Aromatic Diamines with Arylhydrazines Reviewed

    T. Taniguchi, M. Imoto, M. Takeda, T. Nakai, M. Mihara, T. Mizuno, A. Nomoto and A. Ogawa

    Synthesis 雑誌 THIEME   ( 49 )   1623 - 1631   2017.01

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  • A Next-Generation Bifunctional Photosensitizer with Improved Water-Solubility for Photodynamic Therapy and Diagnosis Reviewed

    H. Nishie, H. Kataoka, S. Yano, J.-i. Kikuchi, N. Hayashi, A. Narumi, A. Nomoto, E. Kubota, and T. Joh

    Oncotarget 雑誌 PCBI   7   74249 - 74268   2016.11

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  • Metal-Free Oxidative Coupling of Benzylamines to Imines under an Oxygen Atmosphere Promoted Using Salicylic Acid Derivatives as Organocatalysts Reviewed

    C.-p. Dong, Y. Higashiura, K. Marui, S. Kumazawa, A. Nomoto, M. Ueshima and A. Ogawa

    ACS Omega 雑誌 ACS   1   799 - 807   2016.11

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  • A Tri-aromatic Amide Hemicryptophane Host: Synthesis and Acetylcholine Binding Reviewed

    Y. Makita, N. Katayama, H.-H. Lee, T. Abe, K. Sogawa, A. Nomoto, S.-i. Fujiwara and A. Ogawa

    Tetrahedron Lett. 雑誌 Elsevier   57   5112 - 5115   2016.11

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  • Anticancer Effects of a New Aminosugar-Conjugated Platinum Complex Agent Against Cisplatin-Resistant Gastric Cancer Reviewed

    N. Hayashi, H. Kataoka, S. Yano, J.-i. Kikuchi, M. Tanaka, H. Nishie, Y. Kinoshita, M. Hatano, A. Nomoto, A. Ogawa, M. Inoue, T. Mizoshita, T. Shimura, Y. Mori, E. Kubota, S. Tanida and T. Joh

    Anticancer Res 雑誌 PCBI   36   6005 - 6009   2016.11

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  • Electrochemical Investigation of Isoprenoid Quinone Productions by Shewanella oneidensis MR-1 Detected by Its Destructive Adsorption on an Indium-Tin-Oxide Electrode Reviewed

    A. Morishita, S. Higashimae, A. Nomoto, H. Shiigi and T. Nagaoka

    J. Electrochem. Soc. 雑誌 ECS   163   G166 - G172   2016.09

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  • Metal-free C-H arylation of aminoheterocycles with arylhydrazines Reviewed

    T. Taniguchi, M. Imoto, M. Takeda, F. Matsumoto, T. Nakai, M. Mihara, T. Mizuno, A. Nomoto, A. Ogawa

    Tetrahedron 雑誌 Elsevier   72 ( 27-28 )   27 - 28   2016.07

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  • Synthesis, spectroscopic characterization, thermal and luminescent properties of new organosulfurfunctionalized platinum(II) bis(alkenylarylalkynyl) complexes Reviewed

    Md. M. Rahman , M. Younus, M. Naher, M. K. Masud, A. Nomoto, A. Ogawa, A. Rudnick, A. Köhler

    J. Org. Chem. 雑誌 ACS   818 ( 185 )   185 - 194   2016.06

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  • Gold-Catalyzed Anti-Markovnikov Selective Hydrothiolation of Unactivated Alkenes Reviewed

    T. Tamai, K. Fujiwara, S. Higashimae, A. Nomoto, and A. Ogawa

    Organic Letters 雑誌 ACS   18 ( 9 )   2114 - 2117   2016.04

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  • Maltotriose-conjugation to a fluorinated chlorin derivative generating a PDT photosensitizer with improved water-solubility

    A. Narumi, T. Tsuji, K. Shinohara, H. Yamazaki, M. Kikuchi, S. Kawaguchi, T. Mae, A. Ikeda, Y. Sakai, H. Kataoka, M. Inoue, A. Nomoto, J. Kikuchih, S. Yano

    Organic & Biomolecular Chemistry   2016 ( 14 )   3608 - 3613   2016.02

  • Highly Selective Phosphinylphosphination of Alkenes with Tetraphenyldiphosphine Monoxide Reviewed

    Y. Sato, S-i. Kawaguchi, A. Nomoto, A. Ogawa

    Angewandte Chemie, International Edition 雑誌 Wiley   2016

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  • Highly Selective Photoinduced Perfluoroalkylation of Vinylsilanes and Its Application to Synthesis of Water-Shedding Polysilanes Reviewed

    A. Yoshimura, A. Nomoto*, M. Uchida, H. Kusano, T. Saeki, A. Ogawa*

    Research on Chemical Intermediates 雑誌 Springer   2016

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  • Photoinduced metal-free diboration of alkynes in the presence of organophosphine catalysts Reviewed

    A. Yoshimuraa, Y. Takamachi, K. Mihara, T. Saeki, S. Kawaguchi, Li-Biao Han, A. Nomoto, A. Ogawa

    Tetrahedron 雑誌 Elsevier   2016

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  • Palladium-Catalyzed Markovnikov-Selective Hydroselenation of N-Vinyl Lactams with Selenols Affording N,Se-Acetals Reviewed

    T. Tamai, M. Yoshikawa, S. Higashimae, A. Nomoto, A. Ogawa

    J. Org. Chem. 雑誌 ACS   81   324 - 329   2015.12

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  • Green Oxidation of Amines to Imines Based on the Development of Novel Catalytic Systems Using Molecular Oxygen or Hydrogen Peroxide Reviewed

    K. Marui, A. Nomoto, H. Akashi and A. Ogawa

    Synthesis 雑誌 Thieme   48   31 - 42   2015.11

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  • Photoinduced Synthesis of P-perfluoroalkylated Phosphines from Triarylphosphines and Their Application in the Copper-free Cross-coupling of Acid Chlorides and Terminal Alkynes Reviewed

    Y. Sato, S. Kawaguchi and A. Ogawa

    Adv. Synth. Catal 雑誌 Wiley   357   2509 - 2519   2015.08

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  • Hydrolysis of Diazonium Salts Using a Two-Phase System (CPME and Water) Reviewed

    T. Taniguchi, M. Imoto, M. Takeda, T. Nakai, M. Mihara, T. Iwai, T. Ito, T. Mizuno, A. Nomoto, Akiya Ogawa

    Heteroatom Chem. 雑誌 Wiley   26 ( 6 )   411 - 416   2015.07

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  • Synthesis of a novel cysteine-incorporated anthraquinone derivative and its structural properties Reviewed

    A. Nomoto, T. Taniguchi, Y. Minatobe, S. Katao, K. Kakiuchi, S. Yano, and A. Ogawa

    Molecules 雑誌 MDPI   20 ( 6 )   10192 - 10204   2015.06

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  • Eco-friendly copper sulfate-catalyzed oxidation of amines to imines by hydrogen peroxide in water Reviewed

    K. Marui, A. Nomoto, M. Ueshima and A. Ogawa

    Tetrahedron Lett. 雑誌 Elsevier   56 ( 10 )   1200 - 1202   2015.01

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  • Selective Thiolative Lactonization of Internal Alkynes Bearing a Hydroxyl Group with Carbon Monoxide and Organic Disulfides Catalyzed by Transition-Metal Complexes Reviewed

    S. Higashimae, T. Tamai, A. Nomoto, and A. Ogawa

    J. Org. Chem. 雑誌 ACS   2015

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  • Pinacol couplings of a series of aldehydes and ketones with SmI2/Sm/Me3SiCl in DME Reviewed

    A. Yoshimura, T. Saeki, A. Nomoto, and A. Ogawa

    Tetrahedron 雑誌 Elsevier   2015

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  • カルコゲン原子複合導入による共役系分子の合成と分子構造 Reviewed

    野元昭宏、小川昭弥

    有機合成化学協会誌 雑誌 有機合成化学協会   72 ( 8 )   910 - 918   2014.08

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  • Towards Rational Modulation of In-Plane Molecular Arrangements in Metal-Organic Framework Nanosheets Reviewed

    R. Makiura, R. Usui, Y. Sakai, A. Nomoto, A. Ogawa, O. Sakata and A. Fujiwara

    ChemPlusChem 雑誌 Wiley   79 ( 9 )   1352 - 1360   2014.07

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  • Palladium-Catalyzed Dithiolation of Platinum(II) Alkynylarylacetylides with Diphenyl Disulfide Leading to Construction of -Conjugated Systems with Platinum and Thio Groups Reviewed

    M. M. Rahman, A. Nomoto, M. Younus, and A. Ogawa

    Eur. J. Inorg. Chem. 雑誌 Wiley   2014 ( 16 )   2613 - 2617   2014.05

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  • Synthesis of the first sulphur-containing platinum(II)-alkenylarylalkynyl complexes by photoirradiation Reviewed

    M. M. Rahman, M. Younus and A.Ogawa

    RSC Adv. 雑誌 RSC Publishing   4 ( 48 )   25389 - 25392   2014.05

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  • Photoinduced Reductive Coupling of Organochlorosilanes with SmI2/Sm Reviewed

    A. Yoshimura, Y. Tomisaka, Z. Li, A. Nomoto, A. Ogawa

    Heteroatom Chem. 雑誌 Wiley   25 ( 6 )   684 - 689   2014.05

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  • Rhodium-Catalyzed Hydrothiolation of Alkynes with Thiols for Construction of Sulfur-Containing π-Conjugated Systems Reviewed

    A. Yoshimura, A. Nomoto, A. Ogawa

    Res. Chem. Intermed. 雑誌 Springer   40 ( 6 )   2381 - 2389   2014.04

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  • Photoinduced Regio- and Stereoselective Introduction of Phenylchalcogeno Moieties to Ethynylferrocene Reviewed

    A. Nomoto, S. Hayashi, T. Fujiyama, T. Ikeda, K. Hirata, J. Tohma, K. Kakiuchi, W. Nakanishi and A.Ogawa

    Bull. Chem. Soc. Jpn. 雑誌 日本化学会   87 ( 4 )   550 - 552   2014.04

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  • Vanadium-catalyzed green oxidation of benzylic alcohols in water under air atmosphere Reviewed

    K. Marui, Y. Higashiura, S. Kodama, S. Hashidate, A. Nomoto, S. Yano, M. Ueshima and A. Ogawa

    Tetrahedron 雑誌 Elsevier   70 ( 14 )   2431 - 2438   2014.02

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  • Highly Regioselective Palladium-Catalyzed Double Hydroselenation of Terminal Alkynes with Benzeneselenol in the Presence of Acetic Acid Reviewed

    T. Ikeda, T. Tamai, M. Daitou, Y. Minamida, T. Mitamura, H. Kusano, A. Nomoto and A. Ogawa

    Chem. Lett. 雑誌 日本化学会   42   1383 - 1385   2013.08

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  • Highly Selective Perfluoroalkylation of Unsaturated Molecules upon Photoirradiation in BTF as an Organic/Fluorous Hybrid Solvent Reviewed

    Y. Higuchi, S. Higashimae, T. Tamai, A. Nomoto, M. Sonoda and A. Ogawa

    J. Appl. Sol. Chem. Model. 雑誌 Lifescience Global   2   178 - 190   2013.08

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  • An Efficient and Highly Selective Carbonylative Bisthiolation of Internal Alkynes with Organic Disulfides Catalyzed by [Co2(CO)8] Reviewed

    Y. Higuchi, S. Higashimae, T. Tamai, A. Nomoto, M. Sonoda and A. Ogawa

    Chem. Lett. 雑誌 日本化学会   42   1303 - 1304   2013.08

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  • Transition-metal-catalyzed highly regio-and stereoselective Co-polymerization of dialkynylbenzene with benzenedithiol leading to poly(phenylene vinylene sulfide) Reviewed

    T. Ikeda, N. Nakagawa, A. Nomoto, Y. Minatobe, S-i. Fukuzawa, T. Hirao, A. Ogawa

    J. Mater. Sci. Eng. B 雑誌 David   3 ( 7 )   423 - 430   2013.07

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  • Photoinduced synthesis of unsymmetrical diaryl selenides from triarylbismuthines and diaryl diselenides

    Kobiki Yohsuke; Kawaguchi Shin-Ichi; Ohe Takashi; Ogawa Akiya

    Beilstein journal of organic chemistry National Center for Biotechnology Information   ( 9 )   1141 - 1147   2013.06

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  • Synthesis of selenium compounds by free radical addition based on visible-light-activated Se-Se bond cleavage

    Nomoto, Akihiro; Higuchi, Yoshihiro; Kobiki, Yohsuke; Ogawa, Akiya

    Mini-Reviews in Medicinal Chemistry Bentham Science   13 ( 6 )   814 - 823.   2013.05

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  • Highly selective introduction of heteroatom groups to isocyanides and its application to electrocyclic reactions

    Ogawa, Akiya; Tamai, Taichi; Mitamura, Takenori; Nomoto, Akihiro

    Pure Appl. Chem. IUPAC   85 ( 4 )   785 - 799   2013.04

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  • Synthesis and properties of perfluoroalkyl phosphine ligands: photoinduced reaction of diphosphines with perfluoroalkyl iodides

    Kawaguchi Shin-ichi; Minamida Yoshiaki; Ohe Takashi; Nomoto Akihiro; Sonoda Motohiro; Ogawa Akiya

    Angew. Chem., Int. Ed. Wiley   52 ( 6 )   1748 - 1752.   2013.02

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  • Novel Reducing Properties by Using a Combination of SmI2 and a Series of Lanthanoid Metals Reviewed

    Y. Tomisaka, A. Yoshimura, A. Nomoto, M. Sonoda, A. Ogawa

    Res. Chem. Intermed. 雑誌 Springer   39 ( 1 )   43 - 48   2013.01

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  • Highly Regioselective Hydroiodination of Terminal Alkynes and Silylalkynes with Iodine and Phosphorus Reagents Leading to Internal Iodoalkenes

    Kawaguchi, S.-i.; Masuno, H.; Sonoda, M.; Nomoto, A.; Ogawa, A.

    Tetrahedron Elsevier   68 ( 47 )   9818 - 9825   2012.11

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  • Highly selective perfluoroalkylchalcogenation of alkynes by the combination of iodoperfluoroalkanes and organic dichalcogenides upon photoirradiation

    Tamai, T.; Nomoto, A.; Tsuchii, K.; Minamida, Y.; Mitamura, T.; Sonoda, M.; Ogawa, A.

    Tetrahedron Elsevier   68 ( 51 )   10516 - 10522   2012.09

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  • Rhodium-Catalyzed Highly Stereoselective Hydroselenation of Internal Alkynes Bearing an Electron-withdrawing Group Reviewed

    S. Kawaguchi, M. Kotani, A. Nomoto, M. Sonoda, A. Ogawa

    Organometallics 雑誌 ACS   30 ( 24 )   2011.12

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  • 2核錯体でヘテロ原子を追いかけろ!

    野元昭宏

    化学 雑誌 化学同人   12   64 - 65   2011.12

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  • Novel Heterotetranuclear V2Mo2 or V2W2 Complexes with 4,4’-Di-tert-butyl-2,2′-bipyridine: Syntheses, Crystal Structures, and Catalytic Activities Reviewed

    S. Kodama, A. Nomoto, S. Yano, M. Ueshima, A. Ogawa

    Inorg. Chem. 雑誌 ACS   50 ( 20 )   2011.09

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  • Cobalt-Catalyzed Thiolative Lactonization of Alkynes with Double CO Incorporation Reviewed

    Y. Higuchi, S. Atobe, M. Tanaka, I. Kamiya, T. Yamamoto, A. Nomoto, M. Sonoda, A. Ogawa

    Organometallics 雑誌 ACS   30 ( 17 )   2011.08

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  • Vanadium-Catalyzed Atmospheric Oxidation of Benzyl Alcohols Using Water as Solvent Reviewed

    S. Kodama, S. Hashidate, A. Nomoto, S. Yano, M. Ueshima, A. Ogawa

    Chem. Lett. 雑誌 日本化学会   40 ( 5 )   495 - 497   2011.04

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  • Highly Regioselective Double Hydrothiolation of Terminal Acetylenes with Thiols Catalyzed by Palladium Diacetate Reviewed

    T. Mitamura, M. Daitou, A. Nomoto, A. Ogawa

    Bull. Chem. Soc. Jpn. 雑誌 日本化学会   84 ( 4 )   413 - 415   2011.04

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  • Crystal Structures of β-Chalcogeno-α,β-Saturated Chalcogenoesthers Synthesized by Regio- and Stereoselective Addition and Carbonylation Reactions of Terminal Alkynes Catalyzed by Pd(PPh3)4 Reviewed

    T. Ozaki, A. Nomoto, A. Ogawa

    Hetreoat. Chem. 雑誌 Wiley   22 ( 3-4 )   579 - 585   2011.04

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  • 水を反応場とする環境低負荷型リサイクル酸化触媒プロセスの開発

    野元昭宏、植嶌陸男、小川昭弥

    ケミカルエンジニアリング 雑誌 化学工業社   4   273 - 278   2011.04

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  • Photochemical Intramolecular Cyclization of o-Alkynylaryl Isocyanides with Organic Dichalcogenides Leading to 2,4-Bischalcogenated Quinolines Reviewed

    T. Mitamura, K. Iwata, A. Nomoto, A. Ogawa

    Org. Biomol. Chem. 雑誌 RSC   9 ( 10 )   3768 - 3775   2011.03

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  • Transition-Metal-Catalyzed Cyanochalcogenation of Alkynes with Chalcogenocyanates Reviewed

    T. Ozaki, I. Kamiya, J. Kawakami, A. Nomoto, A. Ogawa

    Bull. Chem. Soc. Jpn. 雑誌 日本化学会   84 ( 2 )   155 - 163   2011.02

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  • Highly Regioselective Hydroselenation and Double-Bond Isomerization of Terminal Alkynes with Benzeneselenol Catalyzed by Bis(triphenylphosphine)palladium(II) Dichloride Reviewed

    T. Ozaki, M. Kotani, H. Kusano, A. Nomoto, A. Ogawa

    J. Organomet. Chem. 雑誌 Elsevier   696 ( 1 )   450 - 455   2011.01

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  • Reductive Carboxylation of Alkyl Halides with CO2 by Use of Photoinduced SmI2/Sm Reduction System Reviewed

    A. Nomoto, Y. Kojo, G. Shiino. Y. Tomisaka. I. Mitani, M. Tatsumi, A. Ogawa

    Tetrahedron Lett. 雑誌 Elsevier   51 ( 50 )   6580 - 6583   2010.12

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  • Direct conversion of benzylamines to imines via atmospheric oxidation in the presence of VO(Hhpic)2 catalyst Reviewed

    Kodama S., Ogawa A. 他5名

    Tetrahedron Letters 雑誌 Elsevier   51   2450 - 2452   2010.05

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  • Synthesis of 2-Halogenated Quinolines by Halide-Mediated Intramolecular Cyclization of o-Alkynylaryl Isocyanides Reviewed

    T. Mitamura, A. Nomoto, M. Sonoda, A. Ogawa

    Bull. Chem. Soc. Jpn. 雑誌 日本化学会   83 ( 7 )   822 - 824   2010.05

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  • Rhodium-Catalyzed anti-Markovnikov Type Hydrophosphination of Terminal Alkynes with Diphosphines and Hydrosilanes in the Presence of Oxygen Reviewed

    S. Kawaguchi, M. Kotani, T. Ohe, S. Nagata, A. Nomoto, M. Sonoda, A. Ogawa

    Phosphorus, Sulfur Silicon, Rel. Elem. 雑誌 Taylor & Francis   185 ( 5-6 )   1090 - 1097   2010.05

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  • Highly Selective Phosphinotelluration of Terminal Alkynes Using a (Ph2P)2-(PhTe)2 Mixed System upon Visible Light Irradiation: Straightforward Access to 1-Phosphino-2-telluro-alkenes Reviewed

    Kawaguchi S., Ogawa A. 他4名

    Organometallics 雑誌 ACS   29   312 - 316   2010.01

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  • Palladium-catalyzed regioselective introduction of chalcogen moieties into porphyrin bearing an ethynyl group Reviewed

    Nomoto A., Ogawa A. 他1名

    Research on Chemical Intermediates 雑誌 Springer   35   965 - 971   2009.11

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  • Hydrophilic polymer supported nanoparticles prepared from samarium trichloride and lanthanum trichloride in liquid-phase Reviewed

    Nomoto A., Ogawa A. 他4名

    Research on Chemical Intermediates 雑誌 Springer   35   1027 - 1032   2009.11

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  • Tetranuclear vanadium complex, (VO)4(hpic)4: a recyclable catalyst for oxidation of benzyl alcohols with molecular oxygen Reviewed

    Kodama S., Ogawa A. 他5名

    Dalton Transactions 雑誌 RSC   9708 - 9711   2009.09

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  • Transition-metal-catalyzed hydrothiolation of cyclohexylallene with benzenethiol or diphenyl disulfide Reviewed

    Kodama S., Ogawa A. 他4名

    Journal of Sulfur Chemistry 雑誌 Taylor & Francis   30   309 - 318   2009.08

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    Kind of work:Joint Work  

  • Highly Regioselective Simultaneous Introduction of Phosphino and Seleno Groups into Unsaturated Bonds by the Novel Combination of (Ph2P)2 and (PhSe)2 upon Photoirradiation Reviewed

    S. Kawaguchi, T. Shirai, T. Ohe, A. Nomoto, M. Sonoda, A. Ogawa

    J. Org. Chem. 雑誌 ACS   74 ( 4 )   1751 - 1754   2009.02

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    Kind of work:Joint Work  

  • On the potentially excellent reducing ability of a series of low-valent rare earths induced by photoirradiation. Reviewed

    Tomisaka, Yuri; Nomoto, Akihiro; Ogawa, Akiya*

    Tetrahedron Lett. 雑誌 Elsevier   50 ( 5 )   584 - 586   2009.02

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    Kind of work:Joint Work  

  • Photoinduced hydrophosphinylation of alkenes with diphenylphosphine oxide. Reviewed

    Kawaguchi, Shin-ichi; Nomoto, Akihiro; Sonoda, Motohiro; Ogawa, Akiya*

    Tetrahedron Lett. 雑誌 Elsevier   50 ( 6 )   624 - 626   2009.02

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    Kind of work:Joint Work  

  • Photoaccelerated Reductive Coupling of Acid Chlorides with Conjugate Dienes and Styrenes by Use of Neodymium Metal in N,N-Dimethylacetamide Reviewed

    Li, Zhi-fang; Tomisaka, Yuri; Nomoto, Akihiro; Zhang, Yongmin; Ogawa, Akiya*:

    Chemistry Letters 雑誌 日本化学会   38 ( 1 )   16 - 17   2009.01

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    Kind of work:Joint Work  

  • Copper(0)-Induced Aminocyclopropanation of Olefins via Deselenation of N,N-Disubstituted Aromatic Selenoamides Reviewed

    T. Mitamura, A. Nomoto, M. Sonoda, A. Ogawa

    Tetrahedron 雑誌 Elsevier   64 ( 42 )   9983 - 9988   2008.10

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    Kind of work:Joint Work  

  • A Highly Regioselective Palladium-Catalyzed Hydrophosphination of Alkynes Using a Diphosphine-Hydrosilane Binary System. Reviewed

    Kawaguchi, Shin-ichi; Nagata, Shoko; Nomoto, Akihiro; Sonoda, Motohiro; Ogawa, Akiya*:

    Journal of Organic Chemistry 雑誌 ACS   73 ( 20 )   7928 - 7933   2008.08

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    Kind of work:Joint Work  

  • Photoinduced highly selective thiophosphination of alkynes using a (PhS)2/(Ph2P)2 binary system. Reviewed

    Shirai, Takamune; Kawaguchi, Shin-ichi; Nomoto, Akihiro; Ogawa, Akiya*:

    Tetrahedron Lett., 雑誌 Elsevier   49 ( 25 )   4043 - 4046   2008.06

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    Kind of work:Joint Work  

  • Novel Photoinduced Reduction of Conjugate Dienes by the Combination of Benzenethiol and Diphenyl Diselenide Reviewed

    T. Mitamura, Y. Imanishi, A. Nomoto, M. Sonoda, A. Ogawa

    Bull. Chem. Soc. Jpn. 雑誌 日本化学会   80 ( 12 )   2443 - 2445   2007.12

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    Kind of work:Joint Work  

  • A highly regioselective hydrophosphination of terminal alkynes with tetraphenyldiphosphine in the presence of palladium catalyst Reviewed

    S. Nagata, S. Kawaguchi, M. Matsumoto, I. Kamiya A. Nomoto, M. Sonoda, A. Ogawa

    Tetrahedron Lett., 雑誌 Elsevier   48 ( 36 )   6637 - 6640   2007.09

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    Kind of work:Joint Work  

  • A novel palladium(0)-catalyzed addition of diphenyl disulfide to allenes leading to vicinal disulfides and its application to carbonylation with carbon monoxide Reviewed

    S. Kodama, E. Nishinaka, A. Nomoto, M. Sonoda, A. Ogawa

    Tetrahedron Lett., 雑誌 Elsevier   48 ( 36 )   6312 - 6317   2007.09

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    Kind of work:Joint Work  

  • Photoinduced thiotelluration of isocyanides by using a (PhS)2-(PhTe)2 mixed system, and its application to bisthiolation via radical cyclization Reviewed

    T. Mitamura, Y. Tsuboi, K. Iwata, K. Tsuchii, A. Nomoto, M. Sonoda, A. Ogawa

    Tetrahedron Lett., 雑誌 Elsevier   48 ( 34 )   5953 - 5957   2007.08

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    Kind of work:Joint Work  

  • New Entry to the Constraction of Si-Si Linkage: Sm/SmI2-Induced Efficient Reductive Coupling of Organochlorosilanes. Reviewed

    Z-f. Li, K. Iida, Y. Tomisaka, A. Yoshimura, T. Hirao, A. Nomoto, A. Ogawa

    Organometallics 雑誌 ACS   26 ( 5 )   1212 - 1216   2007.02

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    Kind of work:Joint Work  

  • Highly Selective Double Chalcogenation of Isocyanides Using Disulfide-Diselenide Mixed Systems Reviewed

    K. Tsuchii, Y. Tsuboi, J.Takahashi, N. Sonoda, N A. Nomoto, A. Ogawa

    J. Org. Chem. 雑誌 ACS   72 ( 2 )   415 - 423   2007.01

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    Kind of work:Joint Work  

  • Controlled Growth and Shape Formation of Platinum Nanoparticles and Their Electrochemical Properties Reviewed

    M. Inaba, M. Ando, A. Hatanaka, A. Nomoto, K. Matsuzawa, A. Tasaka, K. Kinumoto, Y. Iriyama, Z. Ogumi

    Electrochimi. Acta 雑誌 Elsevier   52 ( 4 )   1632 - 1638   2006.12

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    Kind of work:Joint Work  

  • Carbonylation of Organic Halides with Carbon Monoxide Mediated by Samarium Diiodide. Improvement and Mechanistic Investigations Reviewed

    Y. Tomisaka, N. Harato, M. Sato, A. Nomoto, A. Ogawa

    Bull. Chem. Soc. Jpn. 雑誌 日本化学会   79 ( 9 )   1444 - 1446   2006.09

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    Kind of work:Joint Work  

  • Self-Assembly of m-Diethynylbenzene Macrocycles Containing Exoannular Chiral Side Chains Reviewed

    Y. Tobe, T. Nagai, S. Araki, T. Ichikawa, A. Nomoto, M. Sonoda, K. Hirose

    Adv. Funct. Mater. 雑誌 Wiley   16 ( 12 )   1549 - 1554   2006.08

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    Kind of work:Joint Work  

  • A Highly Regioselective Cyanothiolation of Alkynes via Oxidative Addition of Thiocyanates to Tetrakis(triphenylphosphine)palladium(0) Catalyst Reviewed

    I. Kamiya, J. Kawakami, S. Yano, A. Nomoto, A. Ogawa

    Organometallics 雑誌 ACS   25 ( 15 )   3562 - 3564   2006.07

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    Kind of work:Joint Work  

  • Transition-Metal-Catalyzed Carbonylation of Allenes with Carbon Monoxide and Thiols Reviewed

    M. Kajitani, I. Kamiya, A. Nomoto, N. Kihara, A. Ogawa

    Tetrahedron 雑誌 Elsevier   62 ( 26 )   6355 - 6360   2006.06

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    Kind of work:Joint Work  

  • Photochemical Behaviors of Tetraphenyldiphosphine in the Presence of Alkynes Reviewed

    S. Kawaguchi, S. Nagata, T. Shirai, K. Tsuchii, A. Nomoto, A. Ogawa

    Tetrahedron Lett. 雑誌 Elsevier   47 ( 23 )   3919 - 3922   2006.06

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    Kind of work:Joint Work  

  • BTFはハロゲン系溶媒の代替となりうるか?

    野元昭宏, 小川昭弥

    化学 雑誌 化学同人   61 ( 2 )   70 - 71   2006.02

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    Kind of work:Joint Work  

  • A Clue to Elusive Macrocycles: Unusually Facile, Spontaneous Polymerization of a Hexagonal Diethynylbenzene Macrocycle Reviewed

    A. Nomoto, M. Sonoda, Y. Yamaguchi, T. Ichikawa, K. Hirose, Y. Tobe

    J. Org. Chem. 雑誌 ACS   71 ( 1 )   401 - 404   2006.01

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    Kind of work:Joint Work  

  • A Facile Photoinduced Iodoperfluoroalkylation of Dienes, Diynes, and Enynes with Perfluoroalkyl Iodides via Selective Radical Cyclization Reviewed

    K. Tsuchii, Y. Ueta, N. Kamada, Y. Einaga, A. Nomoto, A. Ogawa

    Tetrahedron Lett. 雑誌 Elsevier   46 ( 42 )   7275 - 7278   2005.10

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    Kind of work:Joint Work  

  • Role of the Special Pair in the Charge-Separating Event in Photosynthesis Reviewed

    H. OzekiD, A. Nomoto, K. Ogawa, Y. Kobuke, M. Murakami, K. Hosoda, M. Ohtani, S. Nakashima, M. Miyasaka, T. Okada

    Chem. Eur. J. 雑誌 Wiley   10 ( 24 )   6393 - 6401   2004.12

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    Kind of work:Joint Work  

  • Porphyrin Hetero-Dimer as Charge Separating System for Photocurrent Generation Reviewed

    A. Nomoto, H, Mitsuoka, H. Ozeki, Y. Kobuke

    Chem. Commun. 雑誌 RSC   9   1074 - 1075   2003.05

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    Kind of work:Joint Work  

  • Photocurrent Generation System Incorporated with Antenna Function Reviewed

    A. Nomoto, Y. Kobuke

    Chem. Commun. 雑誌 RSC   10   1104 - 1105   2002.05

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    Kind of work:Joint Work  

  • Intramolecular Conformational Control in Ferrocenes Bearing Podand Dipeptide Chains Reviewed

    T. Moriuchi, A. Nomoto, K. Yoshida, T. Hirao

    Organometallics 雑誌 ACS   20 ( 5 )   1008 - 1013   2001.05

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    Kind of work:Joint Work  

  • Chirality Organization of Ferrocenes Bearing Podand Dipeptide Chains: Synthesis and Structural Characterization Reviewed

    T. Moriuchi, A. Nomoto, K. Yoshida, A. Ogawa, T. Hirao

    J. Am. Chem. Soc. 雑誌 ACS   123 ( 1 )   68 - 75   2001.01

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    Kind of work:Joint Work  

  • Characterization of Ferrocene Derivatives Bearing Podand Dipeptide Chains (-L-Ala-L-Pro-OR) Reviewed

    T. Moriuchi, A. NomotoD, K. Yoshida, T. Hirao

    J. Organomet. Chem. 雑誌 Elsevier   589   50 - 88   1999.10

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    Kind of work:Joint Work  

  • Introduction of Ferrocene Pendant Groups along the Double Helical DNA for a Supramolecular Redox System Reviewed

    A. NomotoD, T. Moriuchi, S. Yamazaki, A. Ogawa, T. Hirao

    Nucleic Acids Symposium Series 雑誌 Oxford Journals   39   43 - 44   1998.09

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    Kind of work:Joint Work  

  • A Highly Ordered Ferrocene System Regulated by Podand Peptide Chains Reviewed

    A. Nomoto, T. Moriuchi, S. Yamazaki, A. Ogawa, T. Hirao

    Chem. Commun. 雑誌 RSC   ( 18 )   1963 - 1964   1998.09

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    Kind of work:Joint Work  

  • Aggregation of Ferrocene Pendant Groups along the Backbone of DNA for a Supramolecular Redox System Reviewed

    T. Hirao, A. Nomoto, S. Yamazaki, A. Ogawa, T. Moriuchi

    Tetrahedron Lett. 雑誌 Elsevier   39 ( 24 )   4295 - 4298   1998.06

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    Kind of work:Joint Work  

  • Supramolecular Redox-Active System Consisting of Biomolecule Reviewed

    T. Hirao, A. Nomoto, S. Yamazaki, T. Moriuchi, A. Ogawa

    J. Inorg. Biochem. 雑誌 Elsevier   67 ( 1-4 )   1997.07

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    Kind of work:Joint Work  

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Books and Other Publications

  • Organic Selenium and Tellurium Compounds (2012). Patai's Chemistry of Functional Groups

    A. Nomoto, A. Ogawa( Role: Joint author)

    Wiley  2012.01 

  • 使える!有機合成反応241 実践ガイド

    A. Nomoto, A. Ogawa( Role: Joint author)

    化学同人  2010.04 

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    Responsible for pages:2-3  

  • Environmentally Harmonious Chemistry for the 21st Century

    A. Ogawa, A. Nomoto, M. Sonoda( Role: Joint author)

    Wiley  2010.01 

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    Responsible for pages:123-136  

  • Modern Carbonylation Methods

    A. Nomoto, *A. Ogawa( Role: Joint author)

    Wiley  2008.06 

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    Responsible for pages:291-300  

  • 高分子重合触媒

    A. Nomoto, A. Ogawa( Role: Joint author)

    シーエムシー出版  2006.06 

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    Responsible for pages:266-270  

  • Handbook of Reagents for Organic Synthesis

    A. Nomoto, A. Ogawa( Role: Joint author)

    Wiley  2006.04 

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    Responsible for pages:632-634  

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MISC

  • 【光感受性物質の新展開】臨床応用のための光線力学療法用糖連結光増感剤の開発

    矢野 重信, 片岡 洋望, 田中 守, 鳴海 敦, 野元 昭宏, 大崎 智弘, 岡本 芳晴

    日本レーザー医学会誌   44 ( 1 )   36 - 45   2023.04( ISSN:0288-6200

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    がん治療における長年の夢は,腫瘍を非侵襲的に治療することにある.近年光線力学療法(Photodynamic therapy:PDT)が,低侵襲性の治療法として注目されている.我々はPDT用の光増感剤の生体適合性と腫瘍選択性の向上を目指して,光増感剤(クロリン,C60等)への糖質(グルコース,マンノース,マルトトリオース等)の導入を立案した.なかでもグルコース連結クロリンe6(G-Ce6)は,in vitroおよびin vivoで優れたPDT効果を示した.さらに,がん発症犬に対して極めて良好なPDT効果を示した.(著者抄録)

  • イヌ乳がん細胞に対するグルコース連結クロリンe6を用いた光線力学療法に関する研究

    大崎 智弘, 岡本 芳晴, 野元 昭宏, 矢野 重信, 田中 守, 片岡 洋望

    BIO Clinica   38 ( 4 )   355 - 357   2023.04( ISSN:0919-8237

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    ワールブルグ効果とは、がん細胞が有酸素下においてもミトコンドリアの酸化的リン酸化よりも、グルコース解糖系でATPを産生する現象である。そのため、がん細胞は大量のグルコースを消費する。このようながん細胞の性質を利用して、光増感剤であるクロリンe6にグルコースを連結したグルコース連結クロリンe6(G-Ce6)を新規に合成した。今回、イヌ乳がん(SNP)細胞に対して、G-Ce6を用いた光線力学療法(PDT)をin vitroおよびin vivoで評価を行った。(著者抄録)

  • 研究者の最新動向 イヌ乳がん細胞に対するグルコース連結クロリンe6を用いた光線力学療法に関する研究

    大崎 智弘, 岡本 芳晴, 野元 昭宏, 矢野 重信, 田中 守, 片岡 洋望

    Precision Medicine   6 ( 1 )   38 - 41   2023.01( ISSN:2434-3625

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    ワールブルグ効果とは,がん細胞が有酸素下においてもミトコンドリアの酸化的リン酸化よりも,グルコース解糖系でATPを産生する現象である。そのため,がん細胞は大量のグルコースを消費する。このようながん細胞の性質を利用して,光増感剤であるクロリンe6にグルコースを連結したグルコース連結クロリンe6(G-Ce6)を新規に合成した。今回,イヌ乳がん(SNP)細胞に対して,G-Ce6を用いた光線力学療法(PDT)をin vitroで評価を行った。(著者抄録)

  • Highly Selective Hydroiodination of Carbon-Carbon Double or Triple Bonds Reviewed

    Y Yamamoto, S Kawaguchi, S Kodama, A Nomoto, A Ogawa

    Curr. Org. Chem.   24 ( 18 )   2020.12

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  • 小動物腫瘍に対する光線力学療法の試み

    大崎智弘, 石塚昌宏, 田中徹, 阪田功, 野元昭宏, 矢野重信, 片岡洋望, 岡本芳晴

    日本レーザー医学会誌   41 ( 3 )   2020( ISSN:0288-6200

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  • 糖連結光感受性薬剤を用いた光線力学療法の前臨床試験

    片岡洋望, 田中守, 西江裕忠, 佐々木槙子, 大崎智弘, 岡本芳晴, 野元昭宏, 矢野重信

    日本レーザー医学会誌   41 ( 3 )   2020( ISSN:0288-6200

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  • 小動物腫瘍に対する光線力学療法

    大崎智弘, 石塚昌宏, 田中徹, 阪田功, 野元昭宏, 矢野重信, 片岡洋望, 岡本芳晴

    日本化学会春季年会講演予稿集(CD-ROM)   99th   2019

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Presentations

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Industrial Property Rights

  • イミン化合物製造用触媒及びイミン化合物の製造方法

    野元昭宏他

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    property_type:Patent 

    Patent/Registration no:6840338 

  • ジ-及びトリアリールメタン染料の製造方法

    野元昭宏他

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    property_type:Patent 

    Patent/Registration no:6501689 

Collaborative research (seeds) keywords

  • photodynamic therapy agent

    Category:Life Science 

  • 錯体触媒 ポリオキソメタレート 環境にやさしい酸化反応

    Category:Green Technology 

  • ナノ粒子合成 燃料電池触媒製造 透過電子顕微鏡 電気化学

    Category:Chemicals / Nano-technology / Materials 

  • ヘテロ原子含有導電性高分子 パイ共役系巨大分子 アセチレン誘導体合成

    Category:Chemicals / Nano-technology / Materials 

  • 機能性ポルフィリンの合成 光励起エネルギー移動 光励起電子移動 表面科学 トンネル電流顕微鏡 原子間力顕微鏡

    Category:Chemicals / Nano-technology / Materials 

  • DNA、タンパク質の構造と機能 酸化還元挙動を示す金属錯体 有機金属触媒合成 有機電気化学

    Category:Life Science 

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Outline of collaborative research (seeds)

  • 有機典型元素化学

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    典型元素を合成材料とした化合物合成に関する研究

  • 医療用薬剤合成

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    医薬をはじめ、医療に用いる薬剤の合成や性質に関する研究

  • Environmental benign organic synthesis

Grant-in-Aid for Scientific Research

  • がん患部への集積能を有する高効率光線力学療法薬剤の創生

    Grant-in-Aid for Scientific Research(B)  2022

  • がん患部への集積能を有する高効率光線力学療法薬剤の創生

    Grant-in-Aid for Scientific Research(B)  2021

  • がん患部への集積能を有する高効率光線力学療法薬剤の創生

    Grant-in-Aid for Scientific Research(B)  2020

  • がん患部への集積能を有する高効率光線力学療法薬剤の創生

    Grant-in-Aid for Scientific Research(B)  2019

  • ヘテロ原子の配位特性を利用した抗癌性糖連結キノリノール白金・パラジウム錯体の合成

    Grant-in-Aid for Scientific Research(C)  2016

  • ヘテロ原子の配位特性を利用した抗癌性糖連結キノリノール白金・パラジウム錯体の合成

    Grant-in-Aid for Scientific Research(C)  2015

  • ヘテロ原子の配位特性を利用した抗癌性糖連結キノリノール白金・パラジウム錯体の合成

    Grant-in-Aid for Scientific Research(C)  2014

  • 非白金元素による燃料電池触媒の開発

    Grant-in-Aid for Scientific Research(C)  2012

  • 非白金元素による燃料電池触媒の開発

    Grant-in-Aid for Scientific Research(C)  2011

  • 異種へテロ原子複合化による機能性発光材料の創出

    2007

  • レドックス活性化に基づく不活性炭素化合物の高効率分子変換法の開発

    2007

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Contract research

  • 癌細胞超選択的光線力学診断法・治療法の開発

    国立研究開発法人日本医療研究開発機構  2019

  • 臨床応用のための新規光感受性糖鎖連結黒林を用いた癌細胞超選択的次世代光線力学療法の開発

    国立大学法人名古屋大学  2016

  • MP28116808317環境にやさしい新酸化触媒反応系を用いるトリアリールメタン系染料合成法の開発

    国立研究開発法人科学技術振興機構  2016

Original item・Special report (Research Activity)

  • 2021

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    Original item:文部科学省ナノテクノロジープラットフォーム
    プレスリリース
    令和3年度「秀でた利用成果」の発表について

    Special report:https://www.nanonet.go.jp/ntj/selection/

  • 2021

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    Original item:https://www.osakafu-u.ac.jp/news/nws20220201/

    Special report:工学研究科の教員が参画する研究開発課題が令和3年度「秀でた利用成果」に選出!

Outline of education staff

  • 主に有機合成化学を応用した授業、演習、実験を担当しています。

Charge of on-campus class subject

  • 有機合成化学特論

    2022   Weekly class   Graduate school

  • 物質化学生命系特別演習第1

    2022   Intensive lecture   Graduate school

  • 応用化学実験I

    2022   Weekly class   Undergraduate

  • 応用化学実験III

    2022   Weekly class   Undergraduate

  • 物質化学生命系特別研究 (応用化学分野)

    2022   Intensive lecture   Graduate school

  • 物質化学生命系特別演習第2 (応用化学分野)

    2022   Intensive lecture   Graduate school

  • 応用化学特論3 (応用化学分野)

    2022   Weekly class   Graduate school

  • 応用化学実験II

    2022   Weekly class   Undergraduate

  • 応用化学実験IV

    2022   Weekly class   Undergraduate

  • 応用化学実験V

    2022   Weekly class   Undergraduate

  • 有機化学IIA

    2022   Weekly class   Undergraduate

  • 有機化学演習IA

    2022   Weekly class   Undergraduate

  • 2021年度 工学研究の最先端

    2021    

  • Laboratory Exercises for Applied Chemistry II

    2021   Practical Training  

  • Laboratory Exercises for Applied Chemistry I

    2021   Practical Training  

  • Laboratory Exercises for Applied Chemistry V

    2021   Practical Training  

  • Laboratory Exercises for Applied Chemistry III

    2021   Practical Training  

  • Advanced Synthetic Organic Chemistry

    2021    

  • Laboratory Exercises for Applied Chemistry IV

    2021   Practical Training  

  • Principles of Organic Chemistry B

    2021    

  • Exercises in Organic Chemistry IA

    2021    

  • Organic Chemistry IIA

    2021    

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Faculty development activities

  • 2021

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    応用化学実験オンラインテキスト  NMR 野元昭宏

  • 2021

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    有機化学IIAオンラインテキスト NMR 野元昭宏

  • 第2回工学全体FDセミナー  2020

  • 工学全体FDセミナー   2019

  • 第2回工学全体FDセミナー  2018

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    学生を授業に巻き込むための“発問法”

  • 大阪府立大学 工学FDセミナー  2017

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    工学教育でアクティブ・ラーニングを導入し、実践する上で必要なこと

  • ルーブリック評価 実践ワークショップ  2013

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    「ルーブリック評価入門講座」の実践

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Visiting Lectures ⇒ Link to the list of Visiting Lectures

  • 環境にやさしい色素合成のための触媒開発

    Category:Modern system science (knowledge information system, environmental system, educational welfare, psychology), Engineering (machinery, electronics / physics, electrical / electronics, electrical information, chemical biotechnology, architecture, cities (civil engineering / environment), material chemistry, aerospace, marine systems, applied chemistry, chemistry, materials)

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    Audience:Preschooler, Schoolchildren, Junior high school students, High school students, College students, Teachers, Researchers, General, Company, Civic organization

    色素は世界的に不足しており、環境にやさしい製法が強く望まれている。その解決策に関する研究

  • 光がん治療のための有機合成化学応用

    Category:Science (mathematics, physics, chemistry, biology, geology, biochemistry), Engineering (machinery, electronics / physics, electrical / electronics, electrical information, chemical biotechnology, architecture, cities (civil engineering / environment), material chemistry, aerospace, marine systems, applied chemistry, chemistry, materials), Nursing (nursing, sex education)

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    Audience:Preschooler, Schoolchildren, Junior high school students, High school students, College students, Teachers, Researchers, General, Company, Civic organization

    光がん治療に用いる薬剤の合成とその使用結果

  • 研究における有機合成反応

    Category:Science (mathematics, physics, chemistry, biology, geology, biochemistry), Engineering (machinery, electronics / physics, electrical / electronics, electrical information, chemical biotechnology, architecture, cities (civil engineering / environment), material chemistry, aerospace, marine systems, applied chemistry, chemistry, materials)

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    Audience:Preschooler, Schoolchildren, Junior high school students, High school students, College students, Teachers, Researchers, General, Company, Civic organization