Updated on 2024/03/18

写真a

 
Tokonami Shiho
 
Organization
Graduate School of Engineering Division of Science and Engineering for Materials, Chemistry and Biology Associate Professor
School of Engineering Department of Applied Chemistry
Title
Associate Professor
Affiliation
Institute of Engineering

Position

  • Graduate School of Engineering Division of Science and Engineering for Materials, Chemistry and Biology 

    Associate Professor  2022.04 - Now

  • School of Engineering Department of Applied Chemistry 

    Associate Professor  2022.04 - Now

Degree

  • 博士（工学） （ Others ） (   Osaka Prefecture University )

Research Interests

  • 電気化学

  • 生体光化学

  • 分析化学

Professional Memberships

  • 電気化学会

  • 日本化学会

  • 日本分析化学会

  • 応用物理学会

  • フローインジェクション分析研究懇談会

Awards

  • OCU先端光科学シンポジウム優秀ポスター賞

    2019.10   OCU先端光科学シンポジウム  

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    Country：Japan

  • Best Poster Award in ICMAT 2019

    2019.06   SPIE(国際光工学会)  

  • Best Poster Award

    2019.06   ICMAT 2019  

  • 平成31年度　科学技術分野の文部科学大臣表彰　若手科学者賞

    2019.04   文部科学省  

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    Country：Japan

  • 平成31年度 文部科学大臣表彰 若手科学賞

    2019.04   文部科学省  

  • 第6回女性化学者奨励賞

    2018.03   日本化学会　第98春季年会  

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    Country：Japan

  • 2017堀場雅夫賞

    2017.10   (株)堀場製作所  

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    Country：Japan

  • Best Paper Award

    2017.04   The 4th Optical Manipulation Conference 2017 (OMC`17)  

  • 2013年度　日本分析化学会奨励賞

    2013.08   日本分析化学会 第61年会実行委員会  

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    Country：Japan

  • JAIMA Poster Presentation Award 2011

    2011.09   JAIMA Discussion on Analytical Science and Technology (JDAST)  

  • FIA Award for Younger Researchers 2011

    2011.09   The Japanese Association for Flow Injection Analysis (JAFIA)  

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    Country：Japan

  • Analytical Science Poster Presentation Award

    2005.12   2005 International Chemical Congress of Pacific Basin Societies  

▼display all

Job Career (off-campus)

  • Osaka Prefecture University

    2017.04 - Now

  • Osaka Prefecture University

    2015.05 - Now

Papers

  • Effect of interface in fiber-based optical condensation

    K. Hayashi, M. Tamura, M. Fujiwara, S. Tokonami, T. Iida

    12606   1260619   2023.09（ ISSN:0277786X ） （ ISBN:9781510663398 ）

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  • Light-induced acceleration of antigen-antibody reaction for detecting attogram-level proteins

    T. Iida, S. Hamatani, Y. Takagi, K. Fujiwara, M. Tamura, S. Tokonami

    12606   1260618   2023.09（ ISSN:0277786X ） （ ISBN:9781510663398 ）

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  • Ultrafast sensitivity-controlled and specific detection of extracellular vesicles using optical force with antibody-modified microparticles in a microflow system.

    Kana Fujiwara, Yumiko Takagi, Mamoru Tamura, Mika Omura, Kenta Morimoto, Ikuhiko Nakase, Shiho Tokonami, Takuya Iida

    Nanoscale horizons   8 ( 8 )   1034 - 1042   2023.07（ ISSN:20556756 ）

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    Publishing type：Research paper (scientific journal)   International / domestic magazine：International journal  

    Extracellular vesicles (EVs), including nanoscale exosomes and ectosomes, hold promise as biomarkers that provide information about the cell of origin through their cargo of nucleic acids and proteins, both on their surface and within. Here, we develop a detection method of EVs based on light-induced acceleration of specific binding between their surface and antibody-modified microparticles, using a controlled microflow with three-dimensional analysis by confocal microscopy. Our method successfully detected 103-104 nanoscale EVs in liquid samples as small as a 500 nanoliters within 5 minutes, with the ability to distinguish multiple membrane proteins. Remarkably, we achieved the specific detection of EVs secreted from living cancer cell lines with high linearity, without the need for a time-consuming ultracentrifugation process that can take several hours. Furthermore, the detection range can be controlled by adjusting the action range of optical force using a defocused laser, consistent with the theoretical calculations. These findings demonstrate an ultrafast, sensitive, and quantitative approach for measuring biological nanoparticles, enabling innovative analyses of cell-to-cell communication and early diagnosis of various diseases, including cancer.

    DOI： 10.1039/d2nh00576j

    PubMed

  • Light-Induced Condensation of Biofunctional Molecules around Targeted Living Cells to Accelerate Cytosolic Delivery.

    Ikuhiko Nakase, Moe Miyai, Kosuke Noguchi, Mamoru Tamura, Yasuyuki Yamamoto, Yushi Nishimura, Mika Omura, Kota Hayashi, Shiroh Futaki, Shiho Tokonami, Takuya Iida

    Nano letters   22 ( 24 )   9805 - 9814   2022.12

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    Publishing type：Research paper (scientific journal)   International / domestic magazine：International journal  

    The light-induced force and convection can be enhanced by the collective effect of electrons (superradiance and red shift) in high-density metallic nanoparticles, leading to macroscopic assembly of target molecules. We here demonstrate application of the light-induced assembly for drug delivery system with enhancement of cell membrane accumulation and penetration of biofunctional molecules including cell-penetrating peptides (CPPs) with superradiance-mediated photothermal convection. For induction of photothermal assembly around targeted living cells in cell culture medium, infrared continuous-wave laser light was focused onto high-density gold-particle-bound glass bottom dishes exhibiting plasmonic superradiance or thin gold-film-coated glass bottom dishes. In this system, the biofunctional molecules can be concentrated around the targeted living cells and internalized into them only by 100 s laser irradiation. Using this simple approach, we successfully achieved enhanced cytosolic release of the CPPs and apoptosis induction using a pro-apoptotic domain with a very low peptide concentration (nM level) by light-induced condensation.

    DOI： 10.1021/acs.nanolett.2c02437

    PubMed

  • Light-Induced Condensation of Biofunctional Molecules around Targeted Living Cells to Accelerate Cytosolic Delivery Reviewed

    I. Nakase*, M. Miyai, K. Noguchia, M. Tamura, Y. Yamamoto, Y. Nishimura, M. Omura, K. Hayashi, S. Futaki, S. Tokonami*, T. Iida*

    22   9805 - 9814   2022.12

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    Kind of work：Joint Work  

  • Quantitative fluorescence spectroscopy of living bacteria by optical condensation with a bubble-mimetic solid-liquid interface Reviewed

    K. Hayashi, M. Tamura, S. Tokonami, T. Iida

    12   125214   2022.12

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    Kind of work：Joint Work  

  • Quantitative fluorescence spectroscopy of living bacteria by optical condensation with a bubble-mimetic solid-liquid interface

    K. Hayashi, M. Tamura, S. Tokonami, T. Iida

    12 ( 12 )   2022.12

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  • Attogram-level light-induced antigen-antibody binding confined in microflow Reviewed

    T. Iida, S. Hamatani, Y. Takagi, K. Fujiwara, M. Tamura, S. Tokonami

    Commun. Biol.   5   1053   2022.10

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    Kind of work：Joint Work  

  • Attogram-level light-induced antigen-antibody binding confined in microflow.

    Takuya Iida, Shota Hamatani, Yumiko Takagi, Kana Fujiwara, Mamoru Tamura, Shiho Tokonami

    Communications biology   5 ( 1 )   1053 - 1053   2022.10

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    Publishing type：Research paper (scientific journal)   International / domestic magazine：International journal  

    The analysis of trace amounts of proteins based on immunoassays and other methods is essential for the early diagnosis of various diseases such as cancer, dementia, and microbial infections. Here, we propose a light-induced acceleration of antigen-antibody reaction of attogram-level proteins at the solid-liquid interface by tuning the laser irradiation area comparable to the microscale confinement geometry for enhancing the collisional probability of target molecules and probe particles with optical force and fluidic pressure. This principle was applied to achieve a 102-fold higher sensitivity and ultrafast specific detection in comparison with conventional protein detection methods (a few hours) by omitting any pretreatment procedures; 47-750 ag of target proteins were detected in 300 nL of sample after 3 minutes of laser irradiation. Our findings can promote the development of proteomics and innovative platforms for high-throughput bio-analyses under the control of a variety of biochemical reactions.

    DOI： 10.1038/s42003-022-03946-0

    PubMed

  • Damage-free light-induced assembly of intestinal bacteria with a bubble-mimetic substrate

    Kota Hayashi, Yasuyuki Yamamoto, Mamoru Tamura, Shiho Tokonami, Takuya Iida

    Communications Biology   4 ( 1 )   2021.12

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    Publishing type：Research paper (scientific journal)  

    Rapid evaluation of functions in densely assembled bacteria is a crucial issue in the efficient study of symbiotic mechanisms. If the interaction between many living microbes can be controlled and accelerated via remote assembly, a cultivation process requiring a few days can be ommitted, thus leading to a reduction in the time needed to analyze the bacterial functions. Here, we show the rapid, damage-free, and extremely dense light-induced assembly of microbes over a submillimeter area with the “bubble-mimetic substrate (BMS)”. In particular, we successfully assembled 104–105 cells of lactic acid bacteria (Lactobacillus casei), achieving a survival rate higher than 95% within a few minutes without cultivation process. This type of light-induced assembly on substrates like BMS, with the maintenance of the inherent functions of various biological samples, can pave the way for the development of innovative methods for rapid and highly efficient analysis of functions in a variety of microbes.

    DOI： 10.1038/s42003-021-01807-w

    PubMed

  • Damage-free light-induced assembly of intestinal bacteria with a bubble-mimetic substrate Reviewed

    K. Hayashi, Y. Yamamoto, M. Tamura, S. Tokonami*, T. Iida*

    4   2021.03

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    Kind of work：Joint Work  

  • Light-induced assembly of living bacteria with honeycomb substrate Reviewed

    S. Tokonami, S. Kurita, R. Yoshikawa, K. Sakurai, T. Suehiro, Y. Yamamoto, M. Tamura, O.Karthaus, T. Iida

    6 ( 9 )   2020.02

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    Kind of work：Joint Work  

  • Light-induced assembly of living bacteria with honeycomb substrate

    Shiho Tokonami, Shinya Kurita, Ryo Yoshikawa, Kenji Sakurai, Taichi Suehiro, Yasuyuki Yamamoto, Mamoru Tamura, Olaf Karthaus, Takuya Iida

    Science Advances   6 ( 9 )   eaaz5757 - eaaz5757   2020.02

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    Publishing type：Research paper (scientific journal)  

    Some bacteria are recognized to produce useful substances and electric currents, offering a promising solution to environmental and energy problems. However, applications of high-performance microbial devices require a method to accumulate living bacteria into a higher-density condition in larger substrates. Here, we propose a method for the high-density assembly of bacteria (10<sup>6</sup> to 10<sup>7</sup> cells/cm<sup>2</sup>) with a high survival rate of 80 to 90% using laser-induced convection onto a self-organized honeycomb-like photothermal film. Furthermore, the electricity-producing bacteria can be optically assembled, and the electrical current can be increased by one to two orders of magnitude simply by increasing the number of laser irradiations. This concept can facilitate the development of high-density microbial energy conversion devices and provide new platforms for unconventional environmental technology.

    DOI： 10.1126/sciadv.aaz5757

    PubMed

  • Interparticle-Interaction-Mediated Anomalous Acceleration of Nanoparticles under Light-Field with Coupled Orbital and Spin Angular Momentum

    Mamoru Tamura, Takashige Omatsu, Shiho Tokonami, Takuya Iida

    Nano Letters   19 ( 8 )   4873 - 4878   2019.08（ ISSN:1530-6984 ）

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    Publishing type：Research paper (scientific journal)  

    Spin-orbit interaction is a crucial issue in the field of nanoscale physics and chemistry. Here, we theoretically demonstrate that the spin angular momentum (SAM) can accelerate and decelerate the orbital motion of nanoparticles (NPs) via light-induced interparticle interactions by a circularly polarized optical vortex. The Laguerre-Gaussian beam as a conventional optical vortex with orbital angular momentum (OAM) induces the orbital and spinning motion of a trapped object depending on the spatial configuration. On the contrary, it is not clear whether circularly polarized light induces the orbital motion for the particles trapped off-axis. The present study reveals that the interparticle light-induced force due to the SAM enhances or weakens the orbital torque and modulates rotational dynamics depending on the number of NPs, where the rotation speed of NPs in the optical field with both positive SAM and OAM can be 4 times faster than that in the optical field with negative SAM and positive OAM. The obtained results will not only clarify the principle for the control of NPs based on OAM-SAM coupling via light-matter interaction but also contribute to the unconventional laser processing technique for nanostructures with various chiral symmetries.

    DOI： 10.1021/acs.nanolett.9b00332

    PubMed

  • Interparticle-interaction-mediated Anomalous Acceleration of Nanoparticles under Light-field with Coupled Orbital and Spin Angular Momentum Reviewed

    M. Tamura*, T. Omatsu, S. Tokonami, T. Iida*

    19 ( 8 )   4873 - 4878   2019.07

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    Kind of work：Joint Work  

  • Electrical Detection of DNA via Nanoparticles under Light-induced Assembly Reviewed

    K. Ohashi, Y. Yamamoto, M. Tamura, Y. Nishimura, S. Tokonami*, T. Iida*

    58   2019.06

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    Kind of work：Joint Work  

  • Development of Bowl-shaped Plasmonic Substrate for Optical Assembly Based on Template of Self-Assembled Microspheres Reviewed

    K. Yamada, M. Tamura, Y. Yamamoto, S. Tokonami, T. Iida

    58   2019.05

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    Kind of work：Joint Work  

  • Surfactant-Controlled Photothermal Assembly of Nanoparticles and Microparticles for Rapid Concentration Measurement of Microbes Reviewed

    Y. Yamamoto, S. Tokonami, T. Iida

    2 ( 4 )   2019.04

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    Kind of work：Joint Work  

  • Surfactant-Controlled Photothermal Assembly of Nanoparticles and Microparticles for Rapid Concentration Measurement of Microbes

    Yasuyuki Yamamoto, Shiho Tokonami, Takuya Iida

    ACS Applied Bio Materials   2 ( 4 )   1561 - 1568   2019.04

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    Publishing type：Research paper (scientific journal)  

    Light-induced heating on a solid-liquid interface can generate a vapor submillimeter bubble and fluid flow, which enables us to densely and rapidly assemble dispersoids into a desired position (photothermal assembly). Here, we revealed that the surface modulation of the light-induced bubble by a surfactant dominates the assembly dynamics of nanoparticles and microparticles as dispersoids, which results in highly efficient photothermal assembly under the surfactant-controlled fluid flow. This mechanism can facilitate the concentration measurement of small objects (microparticles, bacteria, viruses, etc.). Particularly, we found that the surfactant-controlled fluid flow and bubble enable high-density assembly of dispersoids and remarkable enhancement of assembly efficiency, achieving 10-20 times in comparison with the case of no surfactant. This result can extend the limit of measurable concentration by one order. Furthermore, this study revealed the influence of concentration, size, and constituent material of the dispersoids on the assembly efficiency for the improvement of measurement precision. These findings are crucial for laser-induced assembly for the rapid concentration measurement of various microbes without a cultivation process as bioanalysis, for the high-sensitivity detection of harmful particles, and for the colloidal lithography.

    DOI： 10.1021/acsabm.8b00838

  • Microflow-mediated optical assembly of nanoparticles with femtogram protein via shrinkage of light-induced bubbles

    Mayu Ueda, Yushi Nishimura, Mamoru Tamura, Syoji Ito, Shiho Tokonami, Takuya Iida

    APL Photonics   4 ( 1 )   2019.01

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    Publishing type：Research paper (scientific journal)  

    Bottom-up processing of nanobiomaterials enables the creation of a variety of macroscopic structures in natural systems. Here, we use optical means to produce macroscopic-assembled structures of nanoparticles (NPs) from protein molecules by using light-induced bubble (LIB) generation under asymmetric pressure-driven flow in a microchannel. The broadband optical response of assembled NPs facilitates the application of photon pressure and photothermal convection when irradiated by using an infrared laser. The presence of a large amount of protein allows the generation of a vast number of stable LIBs from optically assembled metallic NP-fixed beads (MNFBs). In the case of more diluted albumin solutions, the shrinking of a single LIB can cause the aggregation of MNFBs via fg-level albumin (3.4 fg in the observation region), like a microscale bubblegum. The size of the resulting aggregate can be controlled by changing the concentration of protein. These findings can be used to devise production methods not only for broadband optical nanocomposites but also for label-free methods to detect an extremely small amount of protein.

    DOI： 10.1063/1.5079306

  • Microflow-mediated optical assembly of nanoparticles with femtogram protein via shrinkage of light-induced bubbles Reviewed

    M. Ueda, Y. Nishimura, Y. Yamamoto, S. Tokonami*, T. Iida*

    4   2019.01

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    Kind of work：Joint Work  

  • Electrical detection of DNA via nanoparticles under light-induced assembly

    Karuna Ohashi, Yasuyuki Yamamoto, Mamoru Tamura, Yushi Nishimura, Shiho Tokonami, Takuya Iida

    Japanese Journal of Applied Physics   58 ( SD )   2019（ ISSN:0021-4922 ）

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    Publishing type：Research paper (scientific journal)  

    Rapid, simple, and label-free detection of DNA without fluorescent dyes is desired in the fields of medical diagnosis and food inspection. Electrical measurement using microelectrodes is a promising method for the detection of DNA, whereas it requires multiple pre-treatment processes. In this study, omitting these processes, we demonstrated the possibility of rapid electrical detection of DNA-modified gold nanoparticles and target DNA transported and accumulated between electrodes by photothermal assembly (PTA) under the laser irradiation to a microelectrode. Two types of target DNA molecules with different base sequences were detected within 10 min through the change of electric resistance before and after PTA. The obtained results will be a foundation of a rapid and simple genetic screening method and the detection of various biological nanomaterials based on the electrical measurement mediated by a light-induced assembly.

    DOI： 10.7567/1347-4065/ab1b67

  • Development of bowl-shaped plasmonic substrate for optical assembly based on template of self-assembled microspheres

    Kenshi Yamada, Mamoru Tamura, Yasuyuki Yamamoto, Shiho Tokonami, Takuya Iida

    Japanese Journal of Applied Physics   58 ( SD )   2019（ ISSN:0021-4922 ）

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    Publishing type：Research paper (scientific journal)  

    Photothermal assembly (PTA) is a technique to assemble microscale and nanoscale dispersoids in a suspension. When a solid-liquid interface of a light-absorbing substrate and a suspension liquid is irradiated with a laser, dispersoids are carried toward vicinity of the laser irradiation spot by light-induced convection under the local heating. The transported dispersoids can be accumulated between the micro bubble and substrate. Here, in order to generate light-induced convection and bubble efficiently, we developed a bowl-shaped plasmonic substrate (BPS) which exhibits characteristic optical response in a facile and inexpensive manner based on the self-assembling. Remarkably, we have succeeded in PTA with our developed BPS at a considerably low laser power on the order of several milliwatt (6.1 mW). The obtained characteristic optical response of BPS will open the way to a potential application as a compact and portable sensor for harmful particles and biological targets.

    DOI： 10.7567/1347-4065/ab17c8

  • Macroscopically Anisotropic Structures Produced by Light-induced Solvothermal Assembly of Porphyrin Dimers Reviewed

    Y. Yamamoto, Y. Nishimura, S. Tokonami, N. Fukui, T. Tanaka, A. Osuka, H. Yorimitsu*, T. Iida*

    8   2018.07

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    Kind of work：Joint Work  

  • High-density assembly of micro-dispersoids by laser-induced bubble and fluid flow Reviewed

    Y. Yamamoto, S. Tokonami, T. Iida

    2018.04

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    Kind of work：Joint Work  

  • Optical properties of nano-hole array with randomly designed surface Reviewed

    M. Tamura, S. Tokonami, T. Iida

    2018.04

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    Kind of work：Joint Work  

  • Mechanism in External Field-mediated Trapping of Bacteria Sensitive to Nanoscale Surface Chemical Structure Reviewed

    S. Tokonami, E. Shimizu, M. Tamura, T. Iida*

    7   2017.11

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    Kind of work：Joint Work  

  • Review: Novel Sensing Strategies for Active Bacterial Detection Driven by External Field Reviewed

    S. Tokonami*, T. Iida*

    988   1 - 16   2017.07

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    Kind of work：Joint Work  

  • Macroscopic assembly by optical control of zmol-level DNA hybridization Reviewed

    T. Iida, Y. Nishimura, M. Tamura, K. Nishida, S. Ito, S. Tokonami

    2017.04

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    Kind of work：Joint Work  

  • Optical Trap-Mediated High-Sensitivity Nanohole Array Biosensors with Random Nanospikes Reviewed

    T. Yoshikawa, M. Tamura*, S. Tokonami, T. Iida

    8   370 - 374   2017.01

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    Kind of work：Joint Work  

  • Submillimetre Network Formation by Light-induced Hybridization of Zeptomole-level DNA Reviewed

    T. Iida*, Y. Nishimura, M. Tamura, K. Nishida, S. Ito, S. Tokonami

    6   2016.12

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    Kind of work：Joint Work  

  • Mini-Review: Bacterial Concentration Analysis by Dynamic Guiding in Flow System Reviewed

    Y. Yamamoto, T. Iida,*, S. Tokonami

    33 ( 2 )   89 - 93   2016.12

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    Kind of work：Joint Work  

  • Development of a rapid bacterial counting method based on photothermal assembling Reviewed

    Y. Yamamoto, E. Shimizu, Y. Nishimura, T. Iida*, S. Tokonami

    6 ( 4 )   1280 - 1285   2016.03

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    Kind of work：Joint Work  

  • Electrochemical Evaluation of Poly(3,4-ethylenedioxythiophene) Films Doped with Bacteria Based on Viability Analysis Reviewed

    D. Q. Le, S. Tokonami, T. Nishino H. Shiigi, T. Nagaoka

    105   50 - 55   2015.10

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    Kind of work：Joint Work  

  • Catalytic Activities for Glucose Oxidation of Au/Pd Bimetallic Nanoparticles Prepared via Simultaneous NaBH4 Reduction Reviewed

    S. Tokonami, H. Zhang, Y. Cao, L. Lu, Z. Cheng, S. Zhang

    15 ( 8 )   5785 - 5793   2015.08

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    Kind of work：Joint Work  

  • Voltammetric Detection and Profiling of Isoprenoid Quinones Hydrophobically Transferred From Bacterial Cells Reviewed

    D. Q. Le, A. Morishita, S. Tokonami, T. Nishino, H. Shiigi, M. Miyake, T. Nagaoka

    87 ( 16 )   8416 - 8423   2015.07

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    Kind of work：Joint Work  

  • Development of an bservation Platform for Bacterial Activity Using Polypyrrole Films Doped with Bacteria Reviewed

    L.Q. Dung, M. Takai, S. Suekuni, S. Tokonami, T. Nishino, H. Shiigi, T. Nagaoka

    87   4047 - 4052   2015.03

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    Kind of work：Joint Work  

  • A High Performance Photothermal Film with Spherical Shell-type Metallic Nanocomposites for Solar Thermoelectric　Conversion Reviewed

    A.Kosuga*, Y.Yamamoto, M.Miyai, M.Matsuzawa, Y.Nishimura, S.Hidaka, K.Yamamoto, S.Tanaka, Y.Yamamoto, S.Tokonami, T.Iida*

    2015 ( 7 )   7580 - 7584   2015.03

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    Kind of work：Joint Work  

  • Detection of Biomaterials and Bacteria Using Functionalized Nano-and Micro-Spaces 　　　　　　　　　　　　　　機能性ナノ・マイクロ空間を利用したバイオ関連物質および細菌検出 Reviewed

    S. Tokonami, T. Iida, H. Shiigi, T. Nagaoka

    2015

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    Kind of work：Joint Work  

  • 熱分解DNA ナノファイバのフォトルミネセンス特性 Reviewed

    中尾秀信、床波志保、山本陽二郎、椎木弘、武田良彦

    表面科学 雑誌   36 ( 7 )   357 - 362   2015

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    Kind of work：Joint Work  

  • Fluorescent Carbon Nanowire Made by Pyrolysis of DNA Nanofiber and Plasmon-Asisted Emission Enhancement of Its Fluorescence Reviewed

    H. Nakao, S. Tokonami, Y. Yamamoto, H. Shiigi, Y. Takeda

    50   6252 - 6255   2014.08

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    Kind of work：Joint Work  

  • Control of Submillimeter Phase Transition by Collective Photothermal Effect Reviewed

    Y. Nishimura, K. Nishida, Y. Yamamoto, S. Ito, S. Tokonami, T. Iida

    118 ( 32 )   18799 - 18804   2014.07

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    Kind of work：Joint Work  

  • Construction of nanoantennas on the bacterial outer membran Reviewed

    H. Shiigi, M. Fukuda, T. Tono, K. Takada, T. Okada, L. Q. Dung, Y. Hatsuoka, T. Kinoshita, M. Takai, S. Tokonami, H. Nakao, T. Nishino, Y. Yamamoto. T. Nagaoka

    2014 ( 50 )   6252 - 625   2014.04

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    Kind of work：Joint Work  

  • Enhanced collective optical response of vast numbers of silver nanoparticles assembled on a microbead Reviewed

    S. Tokonami, K. Nishida, Y. Nishimura S. Hidaka, Y. Yamamoto, H. Nakao, T. Iida

    2014 ( 40 )   2337 - 2346   2014.03

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    Kind of work：Joint Work  

  • Recognition of gram-negative and gram-positive bacteria with a functionalized conducting polymer film Reviewed

    S. Tokonami, Y. Nakadoi, H.Nakata, S.Takami, T. Kadoma, H. Shiigi, T. Nagaoka

    2014 ( 40 )   2327 - 2335   2014.03

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    Kind of work：Joint Work  

  • Theory for optical assembling of anisotropic nanoparticles by tailored light fields under thermal fluctuations Reviewed

    M. Tamura, S. Ito, S. Tokonmai, T. Iida

    2014 ( 40 )   2303 - 2313   2014.03

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    Kind of work：Joint Work  

  • DNA-mediated Anomalous Optical Coupling of Heterogeneous Metallic Nanostructures Reviewed

    S. Tokonami, K. Nishida, S. Hidaka, Y. Yamamoto, H. Nakao, T. Iida

    118 ( 13 )   7235 - 7241   2014.02

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    Kind of work：Joint Work  

  • Selective Optical Assembly of Highly Uniform Nanoparticles by Doughnut-Shaped Beams Reviewed

    S. Ito, H. Yamauchi, M. Tamura, S. Hidaka, H. Hattori, T. Hamada, K. Nishida, S. Tokonami, T. Itoh, H. Miyasaka, T. Iida

    3   2013.10

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    Kind of work：Joint Work  

  • Electrical Properties of Two-Dimensional Gold　Nanoparticle–Alkanethiol Networks Formed on Plastic Microbeads Reviewed

    H. Shiigi, S. Shirai, T. Fujita, H. Morishita, Y. Yamamoto, T. Nishino, S. Tokonami, H. Nakao, T. Nagaoka

    160 ( 9 )   H630 - H635   2013.09

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    Kind of work：Joint Work  

  • Multipole Superradiance from Densely Assembled Metallic Nanoparticles Reviewed

    S. Tokonami, S. Hidaka, K. Nishida, Y. Yamamoto, H. Nakao, T. Iida

    117 ( 29 )   15247 - 15252   2013.06

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    Kind of work：Joint Work  

  • Label-Free and Selective Bacteria Detection Using a Film with Transferred Bacterial Configuration Reviewed

    S. Tokonami, Y. Nakadoi, K. Saimatsu, M. Takahashi, M. Ikemizu, T. Kadoma, L.Q. Dung, H. Shiigi, T. Nagaoka

    85 ( 10 )   4925 - 4929   2013.04

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    Kind of work：Joint Work  

  • Placement of Nanospace on Electrode for Biosensing Reviewed

    H. Shiigi, S. Tokonami, Y. Yamamoto, T. Nagaoka

    28   1037 - 1048   2012.11

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    Kind of work：Joint Work  

  • Direct Observation of One-Dimensional Plasmon Coupling in Metallic Nanofibers Prepared by Evaporation-Induced Self-Assembly with DNA Reviewed

    H. Nakao, S. Tokonami, T. Hamada, H. Shiigi, T. Nagaoka, F. Iwata, Y. Takeda

    4   6814 - 6822   2012.09

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    Kind of work：Joint Work  

  • Mass Production of Monodisperse Gold Nanoparticles in Polyaniline Matrix Reviewed

    H. Shiigi, R. Morita, Y. Muranaka, S. Tokonami, Y. Yamamoto, H. Nakao, T. Nagaoka,

    159 ( 7 )   D442 - 446   2012.07

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    Kind of work：Joint Work  

  • Entrapment of Whole Cell Bacteria into Conducting Polymers Reviewed

    T. Nagaoka, H. Shiig, S. Tokonami, K. Saimatsu

    29 ( 1 )   7 - 10   2012.06

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    Kind of work：Joint Work  

  • Vertical Immobilization of Viable Bacilliform Bacteria into Polyryrrole Films Reviewed

    S. Tokonami, K. Saimatsu, Y. Nakadoi, M. Furuta, H. Shiigi, T. Nagaoka

    28 ( 4 )   319 - 321   2012.04

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    Kind of work：Joint Work  

  • Development of an Electrochemical Cholesterol Sencor System for Food Analysis Reviewed

    T. Nagaoka, S. Tokonami, H. Shiigi, H. Matsumoto, Y. Takagi, Y. Takahashi

    28   187 - 191   2012.02

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    Kind of work：Joint Work  

  • Review: Synthesis and Bioanalytical Applications of Specific-Sharped Metallic Nanostructures Reviewed

    S. Tokonami, Y. Yamamoto, H. Shiigi, T. Nagaoka

    716   76 - 91   2012.02

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    Kind of work：Joint Work  

  • Electrical and Thermal Properties of Conducting Microbead Prepared by Green Electroless Plating Method Using Gold Nanoparticles Reviewed

    S. Tokonami, S. Shirai, I. Ota, N. Shibutani, Y. Yamamoto, H. Shiigi, T. Nagaoka

    158 ( 12 )   D689 - D693   2011.10

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    Kind of work：Joint Work  

  • Organic-Inorganic Hybrid Nanoraspberry Consisted of Gold Nanoparticle and Aniline Oligomer Reviewed

    R. Morita, R. Inoue, S. Tokonami, Y. Yamamoto, M. Nakayama, H. Nakao, H. Shiigi, T. Nagaoka

    158   K95 - K100   2011.02

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    Kind of work：Joint Work  

  • Novel Synthesis, Structure, and Oxidation Catalysis of Ag/Au Bimetallic Nanoparticle Reviewed

    S. Tokonami, N. Morita, K. Takasaki, N. Toshima

    114 ( 23 )   10336 - 10341   2010.06

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    Kind of work：Joint Work  

  • Activity Enhancement of a Screen-Printed Carbon Electrode by Modification with a Gold Nanoparticle for Glucose Determination Reviewed

    M. Iwamoto, S. Tokonami, H. Shiigi, T. Nagaoka

    35 ( 41860 )   919 - 930   2009.11

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    Kind of work：Joint Work  

  • Continuous-flow ATP amplification system on a chip Reviewed

    T. Satoh, Y. Shinoda, S. Tokonami, R. Hirota, K. Noda, A. Kuroda, Y. Murakami

    142 ( 1 )   118 - 122   2009.10

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    Kind of work：Joint Work  

  • Green Electroless Plating Method Using Gold Nanoparticles for Conducting Microbeads: Application to Anisotropic Conductive Films Reviewed

    S. Tokonami, Y. Yamamoto, Y. Mizutani, I. Ota, H. Shiigi, T. Nagaoka

    156 ( 12 )   D558 - D563   2009.10

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    Kind of work：Joint Work  

  • Fabrication of SmCo5 Alloy Magnetic Nanoparticles by Assistance of Copper and Their Magnetic Properties Reviewed

    S. Tokonami, M. Kinjo, M. Inokuchi, N. Toshima

    38 ( 7 )   682 - 683   2009.06

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    Kind of work：Joint Work  

  • Fabrication of Si Nanowire Field-Effect Transistor for Highly Sensitive,Label-Free Biosensing Reviewed

    T. Kudo, T. Kasama, T. Ikeda, Y. Hata, S. Tokonami, S. Yokoyama, T. Kikkawa, H. Sunami, M. Suzuki, K. Okuyama, T. Tabei, K. Ohkura, Y. Kayaba, Y. Tanushi, Y. Amemiya, Y. Cho, T. Monzen, Y. Murakami, A. Kuroda, A. Nakajima

    3615 - 3617   2009.06

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    Kind of work：Joint Work  

  • Self-organization of an Organic-Inorganic Hybrid Nanomushroom by Simple Synthetic Route at Organic/Water Interface Reviewed

    H. Shiigi, R. Morita, Y. Yamamoto, S. Tokonami, H. Nakao, T. Nagaoka

    24   3615 - 3617   2009.06

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    Kind of work：Joint Work  

  • Micro- and nanosized molecularly imprinted polymers for high-throughput analytical applications Reviewed

    S. Tokonami, H. Shiigi, T. Nagaoka

    641 ( 41641 )   2009.05

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    Kind of work：Joint Work  

  • Open Bridge-Structured Gold Nanoparticle Array for Label-Free DNA Detection Reviewed

    S. Tokonami, H. Shiigi, T. Nagaoka

    80 ( 21 )   8071 - 8075   2008.10

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    Kind of work：Joint Work  

  • Characterization and DNA Sensing Property of Nano-Gapped Array Electrode Reviewed

    S. Tokonami, H. Shiigi, T. Nagaoka

    155 ( 4 )   J105 - J109   2008.02

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    Kind of work：Joint Work  

  • Preparation of Nanogapped Gold Nanoparticle Array for DNA Detection Reviewed

    S. Tokonami, H. Shiigi, T. Nagaoka

    20 ( 4 )   355 - 360   2008.02

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    Kind of work：Joint Work  

  • Highly Sensitive and Selective Chemical Sensing Techniques Using Gold Nanoparticle Assemblies and Superstructures Reviewed

    T. Nagaoka, H. Shiigi, S. Tokonami

    56 ( 4 )   201 - 212   2007.04

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    Kind of work：Joint Work  

  • Development of Electrical DNA Detection Method Using Gold Nanoparticle Marker Reviewed

    S. Tokonami, Y. Nishide, H. Shiigi, T. Nagaoka

    55 ( 12 )   919 - 923   2006.12

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    Kind of work：Joint Work  

  • Development of the Electrical DNA Sensor Reviewed

    S. Tokonami, H. Shiigi, T. Nagaoka

    3 ( 10 )   81 - 86   2006.10

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    Kind of work：Joint Work  

  • Fabrication of High Sensitive Sensor Electrode Using a Nano-gapped Gold Particle Film Reviewed

    S. Tokonami, M. Iwamoto, K. Hashiba, H. Shiigi, T. Nagaoka

    177 ( 26-32 )   2317 - 2320   2006.10

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    Kind of work：Joint Work  

  • Label-Free On-Chip Electronic Detection of DNA-Hybridization on Gold Nanoparticle Film Reviewed

    H. Shiigi, S. Tokonami, H. Yakabe, T. Nagaoka

    127 ( 10 )   3280 - 3281   2005.02

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    Kind of work：Joint Work  

  • Highly Ordered Assemblies of Au Nanoparticles Organized on DNA Reviewed

    H. Nakao, H. Shiigi, Y. Yamamoto, S. Tokonami, T. Nagaoka, S. Sugiyama, T. Ohtani

    3 ( 10 )   1391 - 1394   2003.09

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    Kind of work：Joint Work  

  • Electrical Property and Water Repellency of a Networked Monolayer Film Prepared from Au Nanoparticles Reviewed

    H. Shiigi, Y. Yamamoto, H. Yakabe, S. Tokonami, T. Nagaoka

    9   1038 - 1039   2003.05

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    Kind of work：Joint Work  

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Books and Other Publications

  • 機器分析ハンドブック2 高分子・分離分析編

    床波, 志保, 前田, 耕治, 安川, 智之

    化学同人  2020.10  （ ISBN:9784759820225 ）

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    Total pages：vii, 177p  

    CiNii Books

  • 機器分析ハンドブック

    床波 志保, 前田 耕治 , 安川 智之

    化学同人  2020  （ ISBN:9784759820225 ）

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  • 高分子・分離分析編

    床波 志保, 前田 耕治 , 安川 智之

    化学同人  2020  （ ISBN:9784759820225 ）

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Presentations

Industrial Property Rights

  • 微小物体の捕集装置および捕集キットならびに微小物体の捕集方法

    床波志保、飯田琢也、藤岡一志

    　More details

    property_type：Patent 

    Patent/Registration no：6375578 

  • 被検出物質の検出装置および方法

    飯田琢也, 床波志保

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    property_type：Patent 

    Patent/Registration no：6099108 

  • Device and Method for Detexting an Analyte／被検出物質の検出装置および方法

    T. Iida, S. Tokonami

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    property_type：Patent 

    Patent/Registration no：US 9,903,861 

  • 微生物検出用センサー、その製造方法、およびポリマー層

    池水麦平, 床波志保, 椎木弘, 長岡勉

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    property_type：Patent 

    Patent/Registration no：6077106 

  • 微生物検出用センサーの製造方法

    床波志保, 椎木弘, 長岡勉, 池水麦平, 高橋茉里

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    property_type：Patent 

    Patent/Registration no：6014582 

  • 传感器、传感器的制造方法及聚合物层／微生物検出用センサーおよびその製造方法

    床波志保、椎木弘、長岡勉、池水麦平、高橋茉里

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    property_type：Patent 

    Patent/Registration no：CN 201280011897.7 

  • Microorganism Detection Sensor and Method of Manufacturing the Same／微生物検出用センサーおよびその製造方法

    床波志保、椎木弘、長岡勉、池水麦平、高橋茉里

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    property_type：Patent 

    Patent/Registration no：US 9206461 

  • 金属ナノ粒子集積構造体を利用した被検出物質の検出装置および方法 Device and method for detecting substance of interest utilizing metal-nanoparticles-accumulated structure

    床波志保, 飯田琢也, 山本陽二郎, 椎木弘, 長岡勉

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    property_type：Patent 

    Patent/Registration no：US 9797842 

  • 金属ナノ粒子集積構造体を利用した圧力検出装置、温度検出装置、圧力検出方法、および温度検出方法

    飯田琢也, 床波志保, 山本陽二郎, 椎木弘, 長岡勉

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    property_type：Patent 

    Patent/Registration no：5854350 

  • 金属ナノ粒子集積構造体を利用した被検出物質の検出装置および方法

    床波志保, 飯田琢也, 山本陽二郎, 椎木弘, 長岡勉

    　More details

    property_type：Patent 

    Patent/Registration no：5822239 

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Charge of on-campus class subject

  • Laboratory Exercises for Applied Chemistry II

    2021   Practical Training  

  • Laboratory Exercises for Applied Chemistry V

    2021   Practical Training  

  • Laboratory Exercises for Applied Chemistry IV

    2021   Practical Training  

  • Laboratory Exercises for Applied Chemistry I

    2021   Practical Training  

  • Exercises in Physical Chemistry IA

    2021    

  • Laboratory Exercises for Applied Chemistry III

    2021   Practical Training  

  • Advanced Nanobiochemistry

    2021    

  • Exercises in Chemical Foreign Languages

    2021    

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Social Activities

  • 第68回テクノラボツアー 金ナノ粒子の医療バイオ応用

    2010.04 - 2011.03