Updated on 2024/04/07
Graduate School of Science Department of Biological Chemistry
Professor 2022.04 - Now
School of Science Department of Biological Chemistry
Professor 2022.04 - Now
理学博士 （ The University of Tokyo ）
Life Science / Cell biology / 細胞生物学
Life Science / Functional biochemistry / 機能生物化学
脂肪細胞の分化と肥大化の機構
インスリン応答性糖取り込みの制御機構と糖尿病との関連
前駆脂肪細胞は、インスリンなどの作用により分化が誘導され、脂肪細胞となる。また、形成された脂肪細胞は、さらなる中性脂肪の蓄積を経て、肥大化する。これらの細胞応答における低分子量GTP結合蛋白質Rac1の役割およびその制御機構と作用機序の解明を目指して、研究を進めている。
Joint Research in Organization
2014.04 - Now
インスリンは、骨格筋や脂肪組織に作用して血中の糖の取り込みを促進する。この際の細胞内でのシグナル伝達機構の解析を進めている。とくに、低分子量GTP結合蛋白質Rac1を介するシグナル伝達系の制御機構と作用機序の解明を目指して、研究を進めている。
Joint Research in Organization
2011.04 - Now
Insulin-stimulated translocation of the fatty acid transporter CD36 to the plasma membrane is mediated by the small GTPase Rac1 in adipocytes. Reviewed
Man Piu Chan, Nobuyuki Takenaka, Yuki Abe, Takaya Satoh
Cell. Signal. 117 111102 2024.02
Impaired insulin signaling mediated by the small GTPase Rac1 in skeletal muscle of the leptin-deficient obese mouse. Reviewed
Man Piu Chan, Nobuyuki Takenaka, Takaya Satoh
Int. J. Mol. Sci. 24 ( 14 ) 11531 2023.07
Regulation of de novo lipid synthesis by the small GTPase Rac1 in the adipogenic differentiation of progenitor cells from mouse white adipose tissue. Reviewed
Kiko Hasegawa, Nobuyuki Takenaka, Maaya Yamamoto, Yoshiki Sakoda, Atsu Aiba, Takaya Satoh
Int. J. Mol. Sci. 24 ( 5 ) 4608 2023.02
Atrophy of white adipose tissue accompanied with decreased insulin-stimulated glucose uptake in mice lacking the small GTPase Rac1 specifically in adipocytes. Reviewed
Kiko Hasegawa, Nobuyuki Takenaka, Kenya Tanida, Man Piu Chan, Mizuki Sakata, Atsu Aiba, Takaya Satoh
Int. J. Mol. Sci. 22 ( 19 ) 10753 2021.10
Diverse physiological functions and regulatory mechanisms for signal-transducing small GTPases. Reviewed
Takaya Satoh
Int. J. Mol. Sci. 21 ( 19 ) 7291 2020.10
The guanine nucleotide exchange factor FLJ00068 activates Rac1 in adipocyte insulin signaling. Reviewed
Nobuyuki Takenaka, Mika Nakao, Kiko Hasegawa, Man Piu Chan, Takaya Satoh
FEBS Lett. 594 ( 24 ) 4370 - 4380 2020.09
A crucial role for the small GTPase Rac1 downstream of the protein kinase Akt2 in insulin signaling that regulates glucose uptake in mouse adipocytes Reviewed
Nobuyuki Takenaka, Mika Nakao, Sayaka Matsui, Takaya Satoh
Int. J. Mol. Sci. 20 ( 21 ) 5443 2019.10
A critical role for the small GTPase Rac1 in insulin signaling that regulates glucose uptake in skeletal muscle Reviewed
Takaya Satoh, Nobuyuki Takenaka
Res. Chem. Intermediat. 45 ( 11 ) 5389 - 5397 2019.09
Involvement of the protein kinase Akt2 in insulin-stimulated Rac1 activation leading to glucose uptake in mouse skeletal muscle. Reviewed
Nobuyuki Takenaka, Natsumi Araki, Takaya Satoh
PLOS ONE 14 ( 2 ) e0212219 2019.02
ACK1. Reviewed
Nobuyuki Takenaka, Takaya Satoh
Encyclopedia of Signaling Molecules (2nd Edition, Sangdun Choi, ed) Springer Nature 102 - 108 2017.12
In situ detection of the activation of Rac1 and RalA small GTPases in mouse adipocytes by immunofluorescent microscopy following in vivo and ex vivo insulin stimulation. Reviewed
Nobuyuki Takenaka, Yuma Nihata, Sho Ueda, Takaya Satoh
Cell Signal 39 108 - 117 2017.11
Rac1 activation caused by membrane translocation of a guanine nucleotide exchange factor in Akt2-mediated insulin signaling in mouse skeletal muscle. Reviewed
Nobuyuki Takenaka, Yuma Nihata, Takaya Satoh
PLOS ONE 11 ( 5 ) e0155292 2016.05
Role for RalA downstream of Rac1 in skeletal muscle insulin signalling. Reviewed
Nobuyuki Takenaka, Yukio Sumi, Keiko Matsuda, Junko Fujita, Tetsuya Hosooka, Tetsuya Noguchi, Atsu Aiba, Takaya Satoh
Biochem J 469 ( 3 ) 445 - 454 2015.08
Immunofluorescent detection of the activation of the small GTPase Rac1 in mouse skeletal muscle fibers. Reviewed
Nobuyuki Takenaka, Yuma Nihata, Takaya Satoh
Anal Biochem 476 5 - 7 2015.05
Role of the guanine nucleotide exchange factor in Akt2-mediated plasma membrane translocation of GLUT4 in insulin-stimulated skeletal muscle. Reviewed
Nobuyuki Takenaka, Naoto Yasuda, Yuma Nihata, Tetsuya Hosooka, Tetsuya Noguchi, Atsu Aiba, Takaya Satoh
Cell Signal 26 ( 11 ) 2460 - 2469 2014.11
Molecular mechanisms for the regulation of insulin-stimulated glucose uptake by small guanosine triphosphatases in skeletal muscle and adipocytes. Reviewed
Takaya Satoh
Int J Mol Sci 15 ( 10 ) 18677 - 18692 2014.10
A critical role of the small GTPase Rac1 in Akt2-mediated GLUT4 translocation in mouse skeletal muscle. Reviewed
Nobuyuki Takenaka, Rumi Izawa, Junyuan Wu, Kaho Kitagawa, Yuma Nihata, Tetsuya Hosooka, Tetsuya Noguchi, Wataru Ogawa, Atsu Aiba, Takaya Satoh
FEBS J 281 ( 5 ) 1493 - 1504 2014.03
Rho GTPases in insulin-stimulated glucose uptake.
Takaya Satoh
Small GTPases 5 ( 1 ) e28102 2014.03
The Ras superfamily of small GTP-binding proteins in glucose transporter type 4-mediated glucose uptake signaling in insulin-responsive tissues. Reviewed
Takaya Satoh
Glucose Uptake: Regulation, Signaling Pathways and Health Implications Nova Science Publishers, Hauppauge, NY, USA 235 - 252 2013.07
Akt2 regulates Rac1 activity in the insulin-dependent signaling pathway leading to GLUT4 translocation to the plasma membrane in skeletal muscle cells. Reviewed
Shinsuke Nozaki, Tomoya Takeda, Takuya Kitaura, Nobuyuki Takenaka, Tohru Kataoka, Takaya Satoh
Cell Signal 25 ( 6 ) 1361 - 1371 2013.06
Ras-related C3 botulinum toxin substrate 1 (RAC1) regulates glucose-stimulated insulin secretion via modulation of F-actin. Reviewed
S. Asahara, Y. Shibutani, K. Teruyama, H. Y. Inoue, Y. Kawada, H. Etoh, T. Matsuda, M. Kimura-Koyanagi, N. Hashimoto, M. Sakahara, W. Fujimoto, H. Takahashi, S. Ueda, T. Hosooka, T. Satoh, H. Inoue, M. Matsumoto, A. Aiba, M. Kasuga, Y. Kido
Diabetologia 56 ( 5 ) 1088 - 1097 2013.05
Astroglial IFITM3 mediates neuronal impairments following neonatal immune challenge in mice. Reviewed
Daisuke Ibi, Taku Nagai, Akira Nakajima, Hiroyuki Mizoguchi, Takahiro Kawase, Daisuke Tsuboi, Shin-ichi Kano, Yoshiaki Sato, Masahiro Hayakawa, Ulrike C. Lange, David J. Adams, M. Azim Surani, Takaya Satoh, Akira Sawa, Kozo Kaibuchi, Toshitaka Nabeshima, Kiyofumi Yamada
Glia 61 ( 5 ) 679 - 693 2013.05
ACK1. Reviewed
Takaya Satoh
Encyclopedia of Signaling Molecules Springer 28 - 33 2012.07
Role of RalA downstream of Rac1 in insulin-dependent glucose uptake in muscle cells. Reviewed
Shinsuke Nozaki, Shuji Ueda, Nobuyuki Takenaka, Tohru Kataoka, Takaya Satoh
Cell Signal 24 ( 11 ) 2111 - 2117 2012.07
インスリン応答性糖取り込みの制御機構と糖尿病との関連
脂肪細胞の分化と肥大化の機構
細胞のシグナル伝達とその異常が引き起こす病態
Category：Science (mathematics, physics, chemistry, biology, geology, biochemistry), Agricultural science (applied biology, biofunctional chemistry, green space environmental science)
Job title within the department
School of Science
副学部長 2022.04
Job title within the department
Graduate School of Science
副研究科長 2022.04
Job title within the department
Graduate School of Science
副研究院長 2022.04