Updated on 2024/04/08


Graduate School of Rehabilitation Science Division of Rehabilitation Science Lecturer
School of Medicine Department of Rehabilitation Science
Institute of Rehabilitation Science
Affiliation campus
Habikino Campus


  • Graduate School of Rehabilitation Science Division of Rehabilitation Science 

    Lecturer  2023.04 - Now

  • School of Medicine Department of Rehabilitation Science 

    Lecturer  2023.04 - Now


  • 博士(保健科学) ( Hokkaido University )

  • 修士(保健科学) ( Hokkaido University )

  • 学士(保健学) ( Hokkaido University )

Research Areas

  • Life Science / Psychiatry

  • Life Science / Rehabilitation science

Research Interests

  • 認知機能改善療法

  • 認知機能

  • 児童青年精神医学

  • 作業療法

  • 事象関連電位

Professional Memberships

  • 日本作業療法学会

    2009 - Now   Domestic

  • 日本てんかん学会近畿地方会

    2023 - Now   Domestic

  • 大阪府作業療法学会

    2021.07 - Now   Domestic

  • 認知症予防学会

    2021 - Now   Domestic

  • 日本精神障碍者リハビリテーション学会

    2021 - Now   Domestic

  • The Japanese Society for Child and Adolescent Psychiatry


  • 日本児童青年精神医学会

    2011 - 2019.03   Overseas

  • 北海道作業療法学会

    2009 - 2021.06

  • 日本認知症予防学会

  • 日本精神障害者リハビリテーション学会

  • 日本作業療法学会

  • 大阪府作業療法学会

  • 北海道精神神経学会

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Committee Memberships (off-campus)

  • 演題査読委員   第36回全国教育研究大会  

    2023 - 2024.03 

  • 理事   北海道児童青年精神保健学会  

    2019 - Now 

  • 学術誌査読員   北海道作業療法学会  

    2018 - Now 

  • 演題査読委員   日本作業療法学会  

    2014 - Now 

Job Career (off-campus)

  • 京都大学   医学部   学外非常勤講師

    2020 - Now

  • 河﨑会看護専門学校   看護学部   学外非常勤講師

    2021 - 2023.03

  • 北海道大学   医学部   学外非常勤講師

    2021 - 2022.03


  • Hokkaido University   Doctor's Course   Graduated/Completed

    2011.04 - 2014.03


  • Complement component C3 is associated with body composition parameters and sarcopenia in community-dwelling older adults: a cross-sectional study in Japan.

    Misa Nakamura, Masakazu Imaoka, Keiko Sakai, Takanari Kubo, Ryota Imai, Mitsumasa Hida, Fumie Tazaki, Junya Orui, Takao Inoue, Masatoshi Takeda

    BMC geriatrics   24 ( 1 )   102 - 102   2024.01

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    Publishing type:Research paper (scientific journal)   International / domestic magazine:International journal  

    BACKGROUND: Chronic inflammation is a factor in the pathogenesis of sarcopenia, which is characterized by low muscle mass and reduced strength. Complement C3 is important in the management of the immune network system. This study seeks to determine the relationship between serum C3 levels and body composition and sarcopenia-related status in community-dwelling older adults. METHODS: Study participants were 269 older adults living in rural Japan. A bioelectrical impedance analysis device was used to measure body composition parameters including body mass index (BMI), body fat percentage, waist-hip-ratio, and appendicular skeletal muscle mass index (SMI). Muscle function was measured by handgrip strength and 6-m walking speed. The correlation coefficients for C3 level and measurements were calculated using Pearson correlation analysis. Participants were categorized into normal, pre-sarcopenia, dynapenia, or sarcopenia groups. Sarcopenia was defined according to 2019 Asian Working Group for Sarcopenia definition, dynapenia was defined as low muscle function without low muscle mass, and pre-sarcopenia was defined as the presence of low muscle mass only. The C3 threshold score for sarcopenia status was evaluated by receiver operating characteristic curve (ROC) analysis. RESULTS: Significant positive correlations were found between C3 and BMI, body fat percentage, and waist-hip ratio in both sexes, and further positive correlations with SMI were found in women. The relationship with body fat percentage was particularly strong. Body composition measurements (BMI, body fat percentage, and waist- hip ratio) and C3 levels were lowest in the sarcopenia group compared with the others. ROC analysis showed that the significant threshold of C3 for discriminating between the normal and sarcopenia groups was 105 mg/dL. Multiple logistic regression analysis showed that participants with C3 < 105 mg/dL had an odds ratio of 3.27 (95% confidence interval, 1.49-7.18) for sarcopenia adjusted by sex, age and body fat percentage. CONCLUSION: C3 levels are suggested to be related to body composition and pathophysiological functions of sarcopenia. C3 is expected to become a useful biomarker for sarcopenia, for predicting the onset of the disease and for predicting the effectiveness of interventions.

    DOI: 10.1186/s12877-024-04720-z


  • Impact of employment on the elderly in a super-aging society during the COVID-19 pandemic in Japan.

    Masakazu Imaoka, Fumie Tazaki, Mitsumasa Hida, Ryota Imai, Hidetoshi Nakao, Takao Inoue, Jyunya Orui, Misa Nakamura

    Scientific reports   13 ( 1 )   18564 - 18564   2023.10

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    Publishing type:Research paper (scientific journal)   International / domestic magazine:International journal  

    Employment of the elderly is gaining importance in Japan's super-aging society. However, investigating the role of employment on the health of the elderly population during the coronavirus disease 2019 (COVID-19) pandemic, wherein they were susceptible, is necessary. We aimed to investigate whether the presence or absence of employment affected motor and cognitive functions in the elderly during the COVID-19 pandemic. The study involved 144 individuals aged ≥ 65 years who participated in the medical examination project from August to September 2021. The participants were divided into employed and non-employed groups. The motor function was evaluated by determining the walking speed, skeletal muscle mass, 2-step test, and bone density. Cognitive function was evaluated using the Mini Mental State Examination and Trail Making Test-A/B (TMT-A/B). For statistical examination, univariate analysis and logistic regression analysis were performed using significantly differential variables. Out of the 144 participants, 33 (22.9%) and 111 (77.1%) were in the employed and non-employed groups, respectively. TMT-A had an odds ratio of 0.96 (95% confidence interval 0.94-0.99) and was an independent factor in the employed group. In conclusion, the attention function was significantly higher in the employed group.

    DOI: 10.1038/s41598-023-45270-5


  • Social Buffering Effects during Craft Activities in Parallel Group Session Revealed by EEG Analysis and Parasympathetic Activity. Reviewed

    Junya Orui, Keigo Shiraiwa, Fumie Tazaki, Takao Inoue, Masaya Ueda, Keita Ueno, Yasuo Naito, Ryouhei Ishii

    Neuropsychobiology   1 - 13   2023.08( ISSN:0302-282X

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    Publishing type:Research paper (scientific journal)   International / domestic magazine:International journal  

    INTRODUCTION: The therapeutic structure of occupational therapy (OT) includes groups. Although the presence of others is expected to be relaxing due to the social buffering effect and the tend and befriend theory, it has not been sufficiently validated in accordance with the therapeutic structure of OT. The aim of this study was to investigate the electrophysiological evidence for the effectiveness of parallel groups and states of concentration on craft activities used in OT. METHODS: Thirty healthy young adults were used as controls to measure EEG and autonomic activity during craft activities in three conditions: alone, parallel, and nonparallel. EEG was analyzed using exact low-resolution electromagnetic tomography, and autonomic activity was analyzed using Lorenz plot analysis. RESULTS: Parasympathetic activity was significantly higher in the parallel condition than in the alone condition. A significant negative correlation was found between current source density and parasympathetic activity in the region centered on the right insular cortex in the α1 band, and functional connectivity in regions including the anterior cingulate cortex and insular cortex was associated with autonomic activity. CONCLUSION: Craft activities that occurred during frontal midline theta rhythm also increased parasympathetic activity. The results suggest that the parallel groups used in OT and the intensive state of craft activities induce a social buffering effect that increases parasympathetic activity despite the absence of physical contact or social support. This provides evidence for the effectiveness of the therapeutic structure of occupational activities and groups in OT.

    DOI: 10.1159/000531005


  • Association of depressive symptoms with Geriatric Locomotive Function Scale score in community-dwelling older adults living in the state of emergency.

    Masakazu Imaoka, Misa Nakamura, Fumie Tasaki, Takao Inoue, Junya Orui, Ryota Imai, Mitsumasa Hida, Hidetoshi Nakao, Masatoshi Takeda

    BMC geriatrics   23 ( 1 )   341 - 341   2023.05

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    Publishing type:Research paper (scientific journal)   International / domestic magazine:International journal  

    BACKGROUND: Under the state of emergency, it has been reported that the amount of physical activity among community-dwelling older adults has decreased significantly due to refraining from going out, and there are strong concerns about the Geriatric Locomotive Function Scale and deterioration of mental health. Therefore, this study aimed to investigate whether the depressive state before the coronavirus disease 2019 (COVID-19) pandemic affected the 25-Geriatric Locomotive (GLFS) score during the COVID-19 pandemic among community-dwelling older adults. METHODS: The participants were 194 community-dwelling older adults (45 men, 149 women) with an average age of 75.5 ± 5.5 years who responded to a self-administered survey conducted three times (preliminary, second, and third) from before the 2018 COVID-19 pandemic to March 2021. Individuals with a score of ≥ 10 on the Geriatric Depression Scale 15 (GDS 15) were excluded. The survey items included the 25-question Geriatric Locomotive Function Scale (GLFS25), GDS 15, and other basic attributes. Those with scores of 5 to 9 on the GDS 15 and those with scores of 0 to 4 were assigned to the depressive symptoms (DS) group and the non-DS group, respectively. Statistical analysis was performed using two-way analysis of variance. The Mann-Whitney U test was used for comparisons between the groups. RESULTS: In total, 187 patients were included in the analysis, excluding 7 patients. GLFS 25 showed a significant increase in scores at the second and third time points compared with baseline, and a main effect was confirmed in both groups, with no interaction effect. The second time, the score was 10.0 ± 8.5 and 13.7 ± 10.5 in the non-DS and DS groups, respectively. The third time, the non-DS and DS groups scored 10.8 ± 10.5 and 14.9 ± 10.1 points, respectively, indicating a significant difference. CONCLUSIONS: Our results revealed that the increase in the GLFS 25 score in community-dwelling older adults during the COVID-19 pandemic was related to their DS during normal times before the pandemic. Evaluating such individuals and providing social support may effectively reduce the deterioration of the GLFS 25 score.

    DOI: 10.1186/s12877-023-04077-9


  • Development of Hallux Valgus Classification Using Digital Foot Images with Machine Learning

    Mitsumasa Hida, Shinji Eto, Chikamune Wada, Kodai Kitagawa, Masakazu Imaoka, Misa Nakamura, Ryota Imai, Takanari Kubo, Takao Inoue, Keiko Sakai, Junya Orui, Fumie Tazaki, Masatoshi Takeda, Ayuna Hasegawa, Kota Yamasaka, Hidetoshi Nakao

    Life   13 ( 5 )   1146 - 1146   2023.05

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    Publishing type:Research paper (scientific journal)  

    Hallux valgus, a frequently seen foot deformity, requires early detection to prevent it from becoming more severe. It is a medical economic problem, so a means of quickly distinguishing it would be helpful. We designed and investigated the accuracy of an early version of a tool for screening hallux valgus using machine learning. The tool would ascertain whether patients had hallux valgus by analyzing pictures of their feet. In this study, 507 images of feet were used for machine learning. Image preprocessing was conducted using the comparatively simple pattern A (rescaling, angle adjustment, and trimming) and slightly more complicated pattern B (same, plus vertical flip, binary formatting, and edge emphasis). This study used the VGG16 convolutional neural network. Pattern B machine learning was more accurate than pattern A. In our early model, Pattern A achieved 0.62 for accuracy, 0.56 for precision, 0.94 for recall, and 0.71 for F1 score. As for Pattern B, the scores were 0.79, 0.77, 0.96, and 0.86, respectively. Machine learning was sufficiently accurate to distinguish foot images between feet with hallux valgus and normal feet. With further refinement, this tool could be used for the easy screening of hallux valgus.

    DOI: 10.3390/life13051146

  • Risk level-specific hazardous drinking factors of alcohol use disorders in Japanese university students Reviewed

    Maki Miyajima, Tomoki Miyata, Yui Murakami, Kayano Yotsumoto, Atsuki Ukita, Takafumi Morimoto, Masayoshi Kobayashi, Hiroyuki Tanaka, Sumie Yamada, Yuri Matsusaki, Takao Inoue

    Journal of Substance Use   1 - 6   2022.11( ISSN:1465-9891

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    Authorship:Corresponding author   Publishing type:Research paper (scientific journal)  

    DOI: 10.1080/14659891.2022.2144502

  • Effects of colour narrative in community-dwelling older adults: A mixed methods study. Reviewed

    Risa Takashima, Takao Inoue, Yuko Yoshida, Mari Sakaue, Teppei Suzuki, Katsuhiko Ogasawara

    Scandinavian journal of occupational therapy   29 ( 7 )   542 - 554   2022.10

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    Authorship:Corresponding author   Publishing type:Research paper (scientific journal)   International / domestic magazine:International journal  

    BACKGROUND: Based on occupational storytelling/story-making, this study developed Colour Narrative, a program to promote the health and well-being of community-dwelling older adults. OBJECTIVES: To conduct a pilot study to implement Colour Narrative in a heavy snowfall area of Japan and verify the participants' experiences in the program and its effectiveness. MATERIAL AND METHODS: An advanced mixed methods design was used. The participants were 22 members of a community-based social group for older adults. Quantitative measurements of life functions and health-related quality of life (HRQOL) were conducted before and after the intervention. Qualitative data were collected from focus group interviews regarding the participants' experiences during the intervention process. Lastly, both datasets were integrated. RESULTS: The harsh living conditions due to heavy snowfall reduced the participants' overall activity. In this environment, Colour Narrative encouraged them to control their lives more in their own ways and enhanced their HRQOL. The core of their experiences was 'negotiating occupations'. This negotiation was a highly intellectual task that significantly improved their cognitive function. CONCLUSIONS: The structure and content of Colour Narrative were found to be useful and feasible for community-dwelling older adults. SIGNIFICANCE: Colour Narrative offers a new occupation-based intervention strategy for preventive occupational therapy.

    DOI: 10.1080/11038128.2020.1849395


  • Association between chronic pain with presarcopenia and central sensitization in Japanese community-dwelling older adults: A cross-sectional study. Reviewed

    Ryota Imai, Masakazu Imaoka, Hidetoshi Nakao, Mitsumasa Hida, Fumie Tazaki, Takao Inoue, Junya Orui, Misa Nakamura

    Medicine   101 ( 32 )   e29998   2022.08

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    Publishing type:Research paper (scientific journal)   International / domestic magazine:International journal  

    Older people with chronic pain are at higher risk of developing sarcopenia. Central sensitization (CS) has been implicated in chronic pain among community-dwelling older adults. However, a relationship between CS and chronic pain with sarcopenia has not been established. This cross-sectional study aimed to clarify the relationship between chronic pain with sarcopenia or presarcopenia and CS among community-dwelling older adults. We assessed chronic pain and sarcopenia in 104 older adults participating in community health checks. We defined sarcopenia using the Asian Working Group for Sarcopenia (AWGS) consensus recommendations based on the following outcomes: low muscle mass, low muscle strength, and slow gait speed. Pain-related assessments included pain intensity, the Pain Catastrophizing Scale, the CS Inventory-9, the pressure pain threshold, the Tampa Scale of Kinesiophobia-11, and the EuroQol 5-dimension 5-level (EQ5D-5L). Chronic pain was defined by related symptoms within the month prior to the health check that had continued for ≥ 3 months and corresponded to a numerical rating scale score of ≥ 1 at the site of maximum pain. The prevalence of chronic pain was 43.3%. In addition, the prevalence of chronic pain with sarcopenia or presarcopenia was 29.8%. A logistic regression analysis revealed that the pressure pain threshold (odds ratio: 0.82, 95% CI: 0.95-1.02) and the EQ5D-5L (odds ratio: 0.58, 95% CI: 0.36-0.76) were significantly associated with the presence of chronic pain with sarcopenia or presarcopenia. Chronic pain with sarcopenia or presarcopenia was affected by central sensitization. Therefore, CS should be evaluated in the elderly.

    DOI: 10.1097/MD.0000000000029998


  • ASD者およびASD特性を有する精神科デイケア利用者に対するSCITの有用性の検討

    村上 元, 森元 隆文, 西山 薫, 高見 展江, 井上 貴雄, 池田 望, 北川 信樹

    作業療法の実践と科学   4 ( 3 )   47 - 54   2022.08( ISSN:2434-5806

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  • 入院中の精神障害者のリカバリーと意味のある作業への参加状況の関連

    大類 淳矢, 井上 貴雄, 藤田 周平, 大石 未来, 北田 有沙, 東江 薫, 濱田 実瑠

    大阪河崎リハビリテーション大学紀要   16   32 - 38   2022.03( ISSN:1881-509X

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    [目的]近年、精神科医療において"personal recovery"という考え方が注目されており、リカバリーに影響する様々な因子が検討されているが、個人にとって意味のある作業への参加状況(作業参加)との関連は十分に検討されていない。本研究では,リカバリーと作業参加の関連を明らかにすることを目的とした。[方法]入院する精神障害者30名を対象に、Recovery Assessment Scale(RAS)、Self-completed Occupational Performance Index(SOPI)、その他個人属性を調査した。[結果]RASの総合点は教育年数と有意な負の相関が、SOPIの総合点や「余暇活動領域」、「作業バランス」とそれぞれ有意な正の相関が認められた。重回帰分析の結果、RASには「教育年数」(β=-0.437,p<0.01)、「SOPI作業バランス」(β=0.457,p<0.01)が影響を与えていることが明らかになった。[結論]本研究によりリカバリーに作業参加が影響を与えることが明らかになった。精神障害者への支援の一つとして、個人にとって意味のある作業を見出し、それに取り組む支援を行う必要性があると考えられる。(著者抄録)

  • Differences of expected intervention effects between participant-led and facilitator-led preventive care services in Japan.

    Shan Yun, Risa Takashima, Kazuki Yoshida, Daisuke Sawamura, Takao Inoue, Shinya Sakai

    Hong Kong journal of occupational therapy : HKJOT   34 ( 2 )   83 - 93   2021.12

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    Publishing type:Research paper (scientific journal)   International / domestic magazine:International journal  

    OBJECTIVE: To examine the effect of different management methods on the effectiveness of care preventive programmes for community-dwelling older adults. METHODS: This study comprised two facilitator-led (FL) and one participant-led (PL) preventive care classes in Japan. All participants received the intervention for approximately 12 weeks. Functional assessments, occupational dysfunctions, and subjective health were measured before and after the interventions. A two-way mixed design analysis of covariance (ANCOVA) was adopted to examine the effect of the interventions, adjusted for previous experiences with preventive care services. The level of significance was set at P < 0.05. RESULTS: Fourteen participants in the PL group (76.64 ± 6.48 years, 92.9% women) and 29 participants in the FL group (76.55 ± 5.75 years, 75.9% women) were included in the statistical analysis. ANCOVA showed significant group × time interaction effects in the Five Times Sit-to-Stand Test (FTSST), the Timed Up & Go (TUG), occupational deprivation of the Classification and Assessment of Occupational Dysfunction Scale, and self-rated health. Simple main effect tests showed that the TUG decreased significantly in the PL group, while occupational deprivation and self-rated health scores improved significantly. In contrast, FTSST scores significantly improved in the FL group. CONCLUSION: PL-type management may be more appropriate for preventing social isolation and withdrawal, while FL-type management may be more appropriate for preventing physical frailty. Selecting not only adequate programmes but also an appropriate management type that matches the service purpose can help provide more effective care preventive services.

    DOI: 10.1177/15691861211022986


  • A Brief, Individualized Exercise Program at Intensities Below the Ventilatory Threshold Exerts Therapeutic Effects for Depression: A Pilot Study.

    Yuri Sakai, Chong Chen, Atsuhito Toyomaki, Naoki Hashimoto, Kan Kitagawa, Takao Inoue, Asumi Sato, Keisuke Makihara, Rie Kameyama, Yumi Wakatsuki, Niki Udo, Ryosuke Shirakawa, Takashi Yokota, Shin Nakagawa, Ichiro Kusumi

    Frontiers in behavioral neuroscience   15   787688 - 787688   2021

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    Publishing type:Research paper (scientific journal)   International / domestic magazine:International journal  

    Due to the fact that existing pharmacological treatments for depression are not ideal, effort has been devoted to the development of complementary, alternative therapies such as physical exercise. The antidepressant effect of exercise is well documented. However, current recommendations and prescriptions of exercise may be too demanding for depressed patients, as some complain about the design of exercise programs and depression is associated with reduced motivation and capacity to exercise. Therefore, appropriately designed, patient-friendly exercise programs may prove critical for the long-term maintenance and therapeutic effects of exercise. In this pilot study, we developed an exercise program based on patients' individual level of ventilatory threshold (VT), a submaximal index of aerobic capacity measured by Cardiopulmonary Exercise Testing (CPX). Compared to traditional measures, CPX provides more trustable indices of aerobic capacity and more homogenous exercise prescriptions. The main episode of the program consisted of 15-25 min of cycling twice a week at an intensity that approached but never went higher than subjects' VT (considered low to moderate in intensity). We found that in patients diagnosed with major depressive disorder or persistent depressive disorder (n = 8), the program resulted in a significant reduction in depressive symptoms at week 8, which was maintained at week 16. Meanwhile, patients' social functioning, quality of life, and cognitive functions improved. Although we used a single arm, non-randomized design, our results suggest that even a brief, low to moderate intensity exercise program may exert therapeutic effects for depression and CPX may be a useful tool for exercise prescriptions.

    DOI: 10.3389/fnbeh.2021.787688


  • 重篤気分調節症(Disruptive Mood Dysregulation Disorder;DMDD)の臨床的研究

    脇坂 友也, 井上 貴雄, 藪岸 翔子, 青木 楓, 松嵜 由莉, 村田 和香, 須藤 章, 傳田 健三

    北海道児童青年精神保健学会会誌   ( 32-33 )   61 - 70   2019.12

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Books and Other Publications

  • 精神科リハビリテーション評価法ハンドブック

    早坂友成 岩根達郎 森元隆文( Role: Contributor)

    中外医学社  2023.04  ( ISBN:978-4-498-22946-4

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    Total pages:563  

  • メタ認知トレーニングをはじめよう!

    石垣琢磨( Role: Contributor)

    星和書店  2022.04  ( ISBN:978-4-7911-1095-7

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    Total pages:299  

  • 「精神疾患における認知機能障害の矯正法」臨床家マニュアル

    Medalia Alice., Herlands Tiffany., Saperstein Alice, Revheim Nadine., 橋本 直樹 , 池澤 聰 , 最上 多美子, 豊巻 敦人 , 森元 隆文 , 井上 貴雄 , 國田 幸治 , 中込 和幸

    星和書店  2019  ( ISBN:9784791110391

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  • 【気分障害の認知機能障害】認知機能障害に焦点をあてた気分障害のリワーク

    北川 信樹, 井上 貴雄

    臨床精神薬理   22 ( 1 )   43 - 50   2019.01( ISSN:1343-3474

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Grant-in-Aid for Scientific Research

  • 統合失調症に対する認知リハビリテーションによる脳内ネットワーク変化の解析

    Grant-in-Aid for Scientific Research(C)  2023

  • 「パラレルな場(並行集団)」での作業療法がもたらす効果の脳科学的機序の解明

    Grant-in-Aid for Scientific Research(C)  2023

  • 統合失調症に対する認知リハビリテーションが脳の神経活動に与える効果の解明

    Grant-in-Aid for Early-Career Scientists  2017.04

Charge of on-campus class subject

  • 作業療法研究法1

    2023   Weekly class   Undergraduate

  • 作業療法学卒業研究III

    2023   Weekly class   Undergraduate

  • 精神障害作業療法学2

    2023   Weekly class   Undergraduate

  • 初年次ゼミナール

    2023   Weekly class   Undergraduate

  • 人間発達学

    2023   Weekly class   Undergraduate

Charge of off-campus class subject

  • 精神・認知機能リハビリテーション学

    Institution:Kyoto University

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    Level:Undergraduate (specialized) 

  • 精神障害作業療法学


  • 精神障害評価学実習


  • 精神障害作業療法学実習


  • 精神機能作業療法評価学

    Institution:Osaka Kawasaki Rehabilitation University

  • Psychiatric Occupational Therapy

    Institution:Osaka Kawasaki Rehabilitation University

  • 就労支援学

    Institution:Osaka Kawasaki Rehabilitation University

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Number of instructed thesis, researches

  • 2023

    Number of graduation thesis reviews:12