Updated on 2026/03/16

写真a

 
KAKU NATSUKO
 
Organization
Graduate School of Medicine Department of Basic Medical Science Lecturer
School of Medicine Department of Medical Science
Title
Lecturer
Affiliation
Institute of Medcine

Position

  • Graduate School of Medicine Department of Basic Medical Science 

    Lecturer  2023.04 - Now

  • School of Medicine Department of Medical Science 

    Lecturer  2023.04 - Now

Degree

  • 学士（医学） （ Oita University ）

  • 博士（医学） （ Kyoto Prefectural University of Medicine ）

  • 修士（生活科学） （ Doshisha Women's College of Liberal Arts ）

  • 学士（生活科学） （ Doshisha Women's College of Liberal Arts ）

Research Areas

  • Life Science / Virology

  • Life Science / Immunology

  • Life Science / Parasitology

Papers

  • Intra-familial transmission of Hepatitis B virus in a peri-urban community from the Democratic Republic of the Congo. Reviewed

    Florence Cindibu Kalonji, Yu Nakagama, Evariste Tshibangu-Kabamba, Nadine Kayiba Kalenda, Shun Nakagama, Sachie Nakagama, Pathy Kamanga Nkolongo, Nestor Kalala-Tshituka, Alphonse Lufuluabu Mpemba, Faustin Ndjibu Mpoji, André Kabongu Kalala, Benjamin Muamba Mpoyi, Dieudonné Mumba Ngoyi, Natsuko Kaku, Yusuke Shimakawa, Ghislain Tumba Disashi, Yasutoshi Kido

    Tropical medicine and health   53 ( 1 )   99 - 99   2025.07（ ISSN:13488945 ）

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    Publishing type：Research paper (scientific journal)   International / domestic magazine：Domestic journal  

    BACKGROUND: Despite global elimination targets set for 2030, Hepatitis B virus (HBV) infection remains a major public health challenge in low-income countries, including the Democratic Republic of Congo (DRC). Limited evidence on the regional transmission pathways precludes progress towards HBV elimination. This study aimed to assess the prevalence, molecular characteristics, and transmission dynamics of HBV in the Lukelenge health district, a peri-urban area in central DRC. METHODS: We employed a two-tiered recruitment strategy: community member volunteers were enrolled during the first phase, and upon notification of HBV positivity in an index case, family contacts were subsequently recruited in the second phase. Participants were screened for hepatitis B surface antigen (HBsAg), followed by PCR amplification of HBV DNA and sequencing. Genotyping and phylogenetic analysis of preS/S sequences were performed to explore regional HBV diversity and transmission patterns. RESULTS: A total of 751 participants from 677 households were included. The overall HBsAg prevalence was 3.8% [95% CI 2.6-5.7], with the highest rate (10.1% [95% CI 4.9-18.2]) found in children aged 5 years and younger. All 42 HBV isolates belonged to genotype E, with 97.6% sharing the ayw4 serotype. Mutations with relevancy to immune escape were detected in 9.5% of strains, while those possibly linked to antiviral resistance were found in 4.7%. Maximum likelihood phylogenetic analysis showed intra-familial clustering of preS/S sequences, suggesting that parent-to-child transmission was the most frequent mode of HBV spread in the study population. CONCLUSIONS: HBV in Lukelenge shows intermediate endemicity, especially affecting young children. Intra-familial transmission is revealed to be predominant, likely involving both vertical and horizontal pathways. Family-targeted interventions, including maternal screening and universal birth-dose vaccination, should be prioritized to eliminate HBV in this region.

    DOI： 10.1186/s41182-025-00781-x

    PubMed

  • Intra-familial transmission of Hepatitis B virus in a peri-urban community from the Democratic Republic of the Congo(タイトル和訳中)

    Kalonji Florence Cindibu, Nakagama Yu, Tshibangu-Kabamba Evariste, Kalenda Nadine Kayiba, Nakagama Shun, Nakagama Sachie, Nkolongo Pathy Kamanga, Kalala-Tshituka Nestor, Mpemba Alphonse Lufuluabu, Mpoji Faustin Ndjibu, Kalala Andre Kabongu, Mpoyi Benjamin Muamba, Ngoyi Dieudonne Mumba, Kaku Natsuko, Shimakawa Yusuke, Disashi Ghislain Tumba, Kido Yasutoshi

    Tropical Medicine and Health   53   s41182 - 025   2025.07（ ISSN:1348-8945 ）

  • Natural Reservoir of <i>Trypanosoma cruzi</i> Found in Triatomines Targeting Humans: Results from Nation-wide Vector Surveillance in El Salvador

    Michimuko-Nagahara Yu, Nakagama Yu, Rodriguez Marvin Stanley, Kaku Natsuko, Nitahara Yuko, Candray Katherine, Tshibangu-Kabamba Evariste, Hamano Shinjiro, Hirayama Kenji, Kaneko Akira, Nakajima-Shimada Junko, Onizuka Yoko, Romero José Eduardo, Palacios José Ricardo, Arias Carmen Elena, Mejía William, Alvarenga Ricardo Cardona, Kido Yasutoshi

    JMA Journal   8 ( 2 )   432 - 443   2025.04（ ISSN:2433328X ） （ eISSN:24333298 ）

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    Publishing type：Research paper (scientific journal)   International / domestic magazine：Domestic journal  

    <p><b>Introduction:</b> Chagas disease is one of the most critical of the neglected tropical diseases in Latin America where it poses a serious public health issue. However, the current burden of vectorial transmission from natural reservoirs to humans is unclear. This study aimed to clarify the active mode of transmission to humans disentangled from the feeding pattern of <i>Triatoma dimidiata</i> (<i>T. dimidiata</i>) infected by <i>Trypanosoma cruzi</i> (<i>T. cruzi</i>).</p><p><b>Methods:</b> A total of 1,376 <i>T. dimidiata</i> specimens were collected across the 14 departments of El Salvador. From these specimens, 135 midgut samples from 37 households in eight departments were positive for <i>T. cruzi</i> (n = 135/1,376; 9.8% [95% confidential interval (CI): 8.35%-11.5%]). Using a universal vertebrate primer, vertebrate blood sources were positively identified by next-generation sequence analysis of deoxyribonucleic acid (DNA) extracted from the midgut contents of <i>T. dimidiata.</i></p><p><b>Results:</b> A total of 13 vertebrates were detected as blood sources; humans, and five domestic, three synanthropic, and four sylvatic species. Triatomines identified as having fed on human blood accounted for approximately 67% (n = 90/135 [95% CI: 58.3%-74.1%]) of the samples analyzed.</p><p><b>Conclusions:</b> In this study, a holistic understanding of the feeding patterns of <i>T. cruzi</i>-positive <i>T. dimidiata</i> in El Salvador is dated. The detection of human DNA in the midgut contents of<i> T. dimidiata</i> indicated the possibility of active vectorial transmission to humans.</p>

    DOI： 10.31662/jmaj.2024-0182

    PubMed

    CiNii Research

  • ヒトを標的とするサシガメにおけるTrypanosoma cruziの自然宿主　エルサルバドル全域で行った媒介昆虫調査の結果(Natural Reservoir of Trypanosoma cruzi Found in Triatomines Targeting Humans: Results from Nation-wide Vector Surveillance in El Salvador)

    Michimuko-Nagahara Yu, Nakagama Yu, Rodriguez Marvin Stanley, Kaku Natsuko, Nitahara Yuko, Candray Katherine, Tshibangu-Kabamba Evariste, Hamano Shinjiro, Hirayama Kenji, Kaneko Akira, Nakajima-Shimada Junko, Onizuka Yoko, Eduardo Romero Jose, Ricardo Palacios Jose, Elena Arias Carmen, Mejia William, Cardona Alvarenga Ricardo, Kido Yasutoshi

    JMA Journal   8 ( 2 )   432 - 443   2025.04（ ISSN:2433-328X ）

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    シャーガス病はラテンアメリカで重要な顧みられない熱帯病であり、感染経路としてサシガメ(Triatoma dimidiate)が広く知られている。本研究では、エルサルバドル全域14県で2018年12月～2019年9月に採取されたサシガメ1376匹を対象に、T.cruzi感染の有無と吸血源を調査した。PCRと顕微鏡検査で陽性と判定された135匹(9.8%)を解析対象とし、DNAを抽出後、NGSを用いた12S rRNA解析で吸血源を同定した。その結果、13種の脊椎動物が血液供給源として明らかになり、ヒト、イヌ、ニワトリ、ドブネズミなどが主要な吸血源であった。特にヒト由来DNAは135匹中90匹(67%)から検出され、地域ごとの検出率は33～83%であった。1匹あたり平均2.4種類の宿主血液が検出され、複数の吸血源を保持していた。低感染性宿主(ニワトリ、カエル、ハトなど)の割合が高い家庭では、T.cruzi感染率が低く(<33%)、高感染家庭(≧33%)と比較し有意に感染率が抑制されていた。ヒトとイヌ血液の共検出が多く、両者の間で感染伝播が頻繁に生じている可能性が示された。

  • Cross-Reactive Fc-Mediated Antibody Responses to Influenza HA Stem Region in Human Sera Following Seasonal Vaccination Reviewed

    Ayae Nishiyama, Takuto Nogimori, Yuji Masuta, Tomoka Matsuura, Tetsuo Kase, 近藤亨子, Satoko Ohfuji, Yu Nakagama, Natsuko Kaku, Sachie Nakagama, Yuko Nitahara, Yoshimasa Takahashi, Hiroshi Kakeya, Yasutoshi KIDO, Wakaba Fukushima, Takuya Yamamoto

    Vaccines   13 ( 2 )   2025.01（ ISSN:2076-393X ）

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    Publishing type：Research paper (scientific journal)   International / domestic magazine：International journal  

    Background: Current influenza A vaccines primarily induce neutralizing antibodies targeting the variable hemagglutinin (HA) head domain, limiting their effectiveness against diverse or emerging influenza A virus (IAV) subtypes. The conserved HA stem domain, particularly the long α-helix (LAH) epitope, is a focus of universal vaccine research due to its cross-protective potential. Additionally, Fc-mediated functions such as antibody-dependent cellular cytotoxicity (ADCC) and antibody-dependent cellular phagocytosis (ADCP) are recognized as important protective immune mechanisms. This study evaluated IgG responses to the HA head, stem, and LAH regions and assessed cross-reactive potential through neutralization, ADCC, and ADCP assays. Methods: IgG responses to the HA head, stem, and LAH regions were measured in vaccinated individuals. Functional assays were conducted for neutralization, ADCC, and ADCP to evaluate the association between antibody levels and immune function. Results: The results showed that HA head-specific IgG increased significantly after vaccination in 50 individuals, whereas stem-specific IgG increased by 72% and LAH-specific IgG by 12-14%. Among the induced antibody subclasses, IgG1 was predominantly increased. Neutralization titers were detected in viruses of the same strain as the vaccine strain, but not in classical or pandemic strains (H5N1, H7N9). HA stem-specific IgG1 antibody titers showed a significant correlation with ADCC/ADCP activity breadth, but no correlation was observed with neutralization breadth. Conclusions: These findings suggest that although current influenza vaccines can induce HA stem-targeted cross-reactive antibodies, their quantity may be insufficient for broad cross-protection, underscoring the need for improved vaccine strategies.

    DOI： 10.3390/vaccines13020140

    PubMed

  • Multiple-clone infections of Mpox: Insights from a single primary lesion Reviewed

    Natsuko Kaku, Mayo Yasugi, Evariste Tshibangu-Kabamba, Yoshiyuki Wakabayashi, Yuko Uesaka, Yu Nakagama, Takuto Nogimori, Takuya Yamamoto, Placide Mbala-Kingebeni, Dieudonné Mumba Ngoyi, Eisuke Adachi, Yasutoshi Kido

    CMI Communications   105042 - 105042   2024.10（ ISSN:2950-5909 ）

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.cmicom.2024.105042

  • コンゴ民主共和国におけるマラリアスペクトラム

    加来 奈津子, 城戸 康年

    日本臨床寄生虫学会大会プログラム・講演要旨   35回   24 - 24   2024.06

  • Factors impacting antibody kinetics, including fever and vaccination intervals, in SARS-CoV-2-naïve adults receiving the first four mRNA COVID-19 vaccine doses. Reviewed

    Tomoka Matsuura, Wakaba Fukushima, Yu Nakagama, Yasutoshi Kido, Tetsuo Kase, Kyoko Kondo, Natsuko Kaku, Kazuhiro Matsumoto, Asae Suita, Emiko Mukai, Yuko Nitahara, Ayako Konishi, Ayane Kasamatsu, Sachie Nakagama, Etsuko Nakagami-Yamaguchi, Satoko Ohfuji, Yukihiro Kaneko, Akira Kaneko, Hiroshi Kakeya, Yoshio Hirota

    Scientific reports   14 ( 1 )   7217 - 7217   2024.03（ eISSN:2045-2322 ）

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    Publishing type：Research paper (scientific journal)   International / domestic magazine：International journal  

    To evaluate the antibody response following the initial four doses of mRNA vaccines (BNT162b2 or mRNA-1273) in SARS-CoV-2-naïve healthy adults and investigate factors influencing antibody titer increases, this prospective cohort study was conducted in Japan from March 2021. The study included participants who received either the 1st and 2nd doses (n = 467), 3rd dose (n = 157), or 4th dose (n = 89). Blood samples were collected before and up to 6 months after each dose, and anti-receptor-binding domain antibody levels were measured. Multivariate analysis (usin multiple linear regression or linear mixed models) revealed several factors significantly associated with higher post-vaccination antibody levels, including mRNA-1273 vaccine (after the 1st and 2nd dose), male gender (after the 3rd and 4th doses), younger age (after the 1st and 2nd dose), non-smoking status (after the 2nd dose), non-use of immunosuppressive agents (after the 1st dose), higher pre-vaccination antibody titers (after the 2nd, 3rd, and 4th doses), and higher post-vaccination fever (after the 2nd and 4th doses). Furthermore, longer intervals since the last dose were significantly associated with higher antibody levels after the 3rd and 4th doses. These findings provide valuable insights for optimizing vaccination strategies.

    DOI： 10.1038/s41598-024-57931-0

    PubMed

  • Factors impacting antibody kinetics, including fever and vaccination intervals, in SARS-CoV-2-naïve adults receiving the first four mRNA COVID-19 vaccine doses

    Matsuura Tomoka, Fukushima Wakaba, Nakagama Yu, Kido Yasutoshi, Kase Tetsuo, Kondo Kyoko, Kaku Natsuko, Matsumoto Kazuhiro, Suita Asae, Mukai Emiko, Nitahara Yuko, Konishi Ayako, Kasamatsu Ayane, Nakagama Sachie, Nakagami-Yamaguchi Etsuko, Ohfuji Satoko, Kaneko Yukihiro, Kaneko Akira, Kakeya Hiroshi, Hirota Yoshio

    scientific reports   14   7217   2024.03（ eISSN:20452322 ）

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    scientific reports. 2024, 14, 7217

    CiNii Research

  • Malaria infection among adults residing in a highly endemic region from the Democratic Republic of the Congo. Reviewed

    Nadine Kalenda Kayiba, Yuko Nitahara, Evariste Tshibangu-Kabamba, Denis Kalambayi Mbuyi, Augustin Kabongo-Tshibaka, Nestor Tshituka Kalala, Barthélemy Mukenga Tshiebue, Katherine-Sofia Candray-Medina, Natsuko Kaku, Yu Nakagama, Niko Speybroeck, Dieudonné Ngoyi Mumba, Ghislain Tumba Disashi, Akira Kaneko, Yasutoshi Kido

    Malaria journal   23 ( 1 )   82 - 82   2024.03

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    Publishing type：Research paper (scientific journal)   International / domestic magazine：International journal  

    BACKGROUND: Adults infected with Plasmodium spp. in endemic areas need to be re-evaluated in light of global malaria elimination goals. They potentially undermine malaria interventions but remain an overlooked aspect of public health strategies. METHODS: This study aimed to estimate the prevalence of Plasmodium spp. infections, to identify underlying parasite species, and to assess predicting factors among adults residing in an endemic area from the Democratic Republic of Congo (DRC). A community-based cross-sectional survey in subjects aged 18 years and above was therefore carried out. Study participants were interviewed using a standard questionnaire and tested for Plasmodium spp. using a rapid diagnostic test and a nested polymerase chain reaction assay. Logistic regression models were fitted to assess the effect of potential predictive factors for infections with different Plasmodium spp. RESULTS: Overall, 420 adults with an estimated prevalence of Plasmodium spp. infections of 60.2% [95% CI 55.5; 64.8] were included. Non-falciparum species infected 26.2% [95% CI 22.2; 30.5] of the study population. Among infected participants, three parasite species were identified, including Plasmodium falciparum (88.5%), Plasmodium malariae (39.9%), and Plasmodium ovale (7.5%) but no Plasmodium vivax. Mixed species accounted for 42.3% of infections while single-species infections predominated with P. falciparum (56.5%) among infected participants. All infected participants were asymptomatic at the time of the survey. Adults belonging to the "most economically disadvantaged" households had increased risks of infections with any Plasmodium spp. (adjusted odds ratio, aOR = 2.87 [95% CI 1.66, 20.07]; p < 0.001), compared to those from the "less economically disadvantaged" households. Conversely, each 1 year increase in age reduced the risk of infections with any Plasmodium spp. (aOR = 0.99 [95% CI 0.97, 0.99]; p = 0.048). Specifically for non-falciparum spp., males had increased risks of infection than females (aOR = 1.83 [95% CI 1.13, 2.96]; p = 0.014). CONCLUSION: Adults infected with malaria constitute a potentially important latent reservoir for the transmission of the disease in the study setting. They should specifically be taken into account in public health measures and translational research.

    DOI： 10.1186/s12936-024-04881-7

    PubMed

  • Booster COVID-19 mRNA vaccination ameliorates impaired B-cell but not T-cell responses in older adults. Reviewed

    Kohei Kometani, Takaaki Yorimitsu, Norihide Jo, Erina Yamaguchi, Osamu Kikuchi, Masaru Fukahori, Takeshi Sawada, Yoshitaka Tsujimoto, Ayana Sunami, Mengqian Li, Takeshi Ito, Yann Pretemer, Yuxian Gao, Yu Hidaka, Masaki Yamamoto, Natsuko Kaku, Yu Nakagama, Yasutoshi Kido, Alba Grifoni, Alessandro Sette, Miki Nagao, Satoshi Morita, Takako E Nakajima, Manabu Muto, Yoko Hamazaki

    Frontiers in immunology   15   1455334 - 1455334   2024

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    Publishing type：Research paper (scientific journal)   International / domestic magazine：International journal  

    Age-associated differences in the effect of repetitive vaccination, particularly on memory T-cell and B-cell responses, remain unclear. While older adults (aged ≥65 years) exhibited enhanced IgG responses following COVID-19 mRNA booster vaccination, they produced fewer spike-specific circulating follicular helper T cells-1 than younger adults. Similarly, the cytotoxic CD8+ T-cell response remained diminished with reduced PD-1 expression even after booster vaccination compared with that in younger adults, suggesting impaired memory T-cell activation in older adults. In contrast, although B-cell responses in older adults were weaker than those in younger adults in the primary response, the responses were significantly enhanced upon booster vaccination, reaching levels comparable with that observed in younger adults. Therefore, while booster vaccination ameliorates impaired humoral immunity in older adults by efficiently stimulating memory B-cell responses, it may less effectively enhance T-cell-mediated cellular immunity. Our study provides insights for the development of effective therapeutic and vaccine strategies for the most vulnerable older population.

    DOI： 10.3389/fimmu.2024.1455334

    PubMed

  • Differential cardiomyocyte transcriptomic remodeling during in vitro Trypanosoma cruzi infection using laboratory strains provides implications on pathogenic host responses.

    Candray-Medina KS, Nakagama Y, Ito M, Nakagama S, Tshibangu-Kabamba E, Takeda N, Sugiura Y, Nitahara Y, Michimuko-Nagahara Y, Kaku N, Onizuka Y, Arias CE, Mejia M, Alas K, Peña S, Maejima Y, Komuro I, Nakajima-Shimada J, Kido Y

    Tropical medicine and health   51 ( 1 )   68   2023.12（ ISSN:1348-8945 ）

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  • The landscape of drug resistance in Plasmodium falciparum malaria in the Democratic Republic of Congo: a mapping systematic review.

    Kayiba NK, Tshibangu-Kabamba E, Rosas-Aguirre A, Kaku N, Nakagama Y, Kaneko A, Makaba DM, Malekita DY, Devleesschauwer B, Likwela JL, Zakayi PK, DeMol P, Lelo GM, Hayette MP, Dikassa PL, Kido Y, Speybroeck N

    Tropical medicine and health   51 ( 1 )   64   2023.11（ ISSN:1348-8945 ）

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  • Characteristics of epitope dominance pattern and cross-variant neutralisation in 16 SARS-CoV-2 mRNA vaccine sera.

    Yasugi M, Nakagama Y, Kaku N, Nitahara Y, Hatanaka N, Yamasaki S, Kido Y

    Vaccine   41 ( 42 )   6248 - 6254   2023.10（ ISSN:0264-410X ）

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  • Antibody Avidity Maturation Following Recovery From Infection or the Booster Vaccination Grants Breadth of SARS-CoV-2 Neutralizing Capacity.

    Nakagama Y, Candray K, Kaku N, Komase Y, Rodriguez-Funes MV, Dominguez R, Tsuchida T, Kunishima H, Nagai E, Adachi E, Ngoyi DM, Yamasue M, Komiya K, Hiramatsu K, Uemura N, Sugiura Y, Yasugi M, Yamagishi Y, Mikamo H, Shiraishi S, Izumo T, Nakagama S, Watanabe C, Nitahara Y, Tshibangu-Kabamba E, Kakeya H, Kido Y

    The Journal of infectious diseases   227 ( 6 )   780 - 787   2023.03（ ISSN:0022-1899 ）

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  • Usefulness of seasonal malaria chemoprevention in the Sahel.

    Kalenda NK, Tshibangu-Kabamba E, Nakagama Y, Kaku N, Kaneko A, Speybroeck N, Kido Y

    The Lancet. Infectious diseases   23 ( 3 )   269 - 270   2023.03（ ISSN:1473-3099 ）

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  • Age-adjusted impact of prior COVID-19 on SARS-CoV-2 mRNA vaccine response

    Nakagama S.

    Frontiers in Immunology   14   1087473   2023.01

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  • Cumulative seroprevalence among healthcare workers after the first wave of the COVID-19 pandemic in El Salvador, Central America.

    Nakagama Y, Rodriguez-Funes MV, Dominguez R, Candray-Medina KS, Uemura N, Tshibangu-Kabamba E, Nitahara Y, Kaku N, Kaneko A, Kido Y

    Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases   28 ( 11 )   1508 - 1510   2022.11（ ISSN:1198-743X ）

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  • Kinetics of anti-SARS-CoV-2 antibody titer in healthy adults up to 6 months after BNT162b2 vaccination measured by two immunoassays: A prospective cohort study in Japan

    Matsuura T.

    Vaccine   40 ( 38 )   5631 - 5640   2022.09（ ISSN:0264410X ）

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  • Detecting Waning Serological Response with Commercial Immunoassays: 18-Month Longitudinal Follow-up of Anti-SARS-CoV-2 Nucleocapsid Antibodies.

    Nakagama Y, Komase Y, Kaku N, Nitahara Y, Tshibangu-Kabamba E, Tominaga T, Tanaka H, Yokoya T, Hosokawa M, Kido Y

    Microbiology spectrum   10 ( 4 )   e0098622   2022.08

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  • A Dual-Antigen SARS-CoV-2 Serological Assay Reflects Antibody Avidity.

    Nakagama Y, Nitahara Y, Kaku N, Tshibangu-Kabamba E, Kido Y

    Journal of clinical microbiology   60 ( 2 )   e0226221   2022.02（ ISSN:0095-1137 ）

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  • Antibody testing as the guide to our living with COVID-19

    KAKU Natsuko, NAKAGAMA Yu, NITAHARA Yuko, KIDO Yasutoshi

    Japanese Journal of Thrombosis and Hemostasis   33 ( 3 )   338 - 346   2022（ ISSN:09157441 ） （ eISSN:18808808 ）

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  • Immunogenicity and safety of COVID-19 vaccine in lung cancer patients receiving anticancer treatment: A prospective multicenter cohort study

    Nakashima K.

    Human Vaccines and Immunotherapeutics   18 ( 6 )   2140549   2022（ ISSN:21645515 ）

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  • High-Resolution Linear Epitope Mapping of the Receptor Binding Domain of SARS-CoV-2 Spike Protein in COVID-19 mRNA Vaccine Recipients.

    Nitahara Y, Nakagama Y, Kaku N, Candray K, Michimuko Y, Tshibangu-Kabamba E, Kaneko A, Yamamoto H, Mizobata Y, Kakeya H, Yasugi M, Kido Y

    Microbiology spectrum   9 ( 3 )   e0096521   2021.12

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  • Serological Testing Reveals the Hidden COVID-19 Burden among Health Care Workers Experiencing a SARS-CoV-2 Nosocomial Outbreak.

    Nakagama Y, Komase Y, Candray K, Nakagama S, Sano F, Tsuchida T, Kunishima H, Imai T, Shintani A, Nitahara Y, Kaku N, Kido Y

    Microbiology spectrum   9 ( 2 )   e0108221   2021.10

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  • Longitudinal ventilatory ratio monitoring for COVID-19: its potential in predicting severity and assessing treatment response.

    Kaku N, Nakagama Y, Shirano M, Shinomiya S, Shimazu K, Yamazaki K, Maehata Y, Morita R, Nitahara Y, Yamamoto H, Mizobata Y, Kido Y

    Critical care (London, England)   25 ( 1 )   366   2021.10（ ISSN:1364-8535 ）

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  • 破傷風診療における硫酸マグネシウムの使用に関するアンケート調査結果

    安原 大生, 川島 篤志, 和田 幹生, 花本 明子, 加来 奈津子

    日本プライマリ・ケア連合学会誌   44 ( 2 )   53 - 58   2021.06（ ISSN:2185-2928 ）

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    目的:破傷風は強直性痙攣を引き起こす致命率の高い感染症である.筋症状の治療として硫酸マグネシウムが有効である可能性が報告されているが,その使用実態の知見は乏しい.本研究の目的は重症管理を必要とした破傷風に対する硫酸マグネシウム使用の概要を明らかにすることである.方法:国内で医師が登録する複数のメーリングリストを利用し,重症管理を必要とした破傷風に対する硫酸マグネシウムの使用実態についてアンケート調査を行った.結果:対象となるのべ24,266人のうち計604名からの回答があった.重症管理を必要とした破傷風症例の経験者は252名であり,そのうち硫酸マグネシウムの使用経験者は126名であった.結論:重症管理を要する破傷風症例において,硫酸マグネシウムの使用が相当数認められることが明らかとなった.破傷風治療の選択肢として,硫酸マグネシウムの有用性については更なる知見の蓄積が必要である.(著者抄録)

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Grant-in-Aid for Scientific Research

  • 潜在的感染拡大を明らかにするハイリスク集団におけるMpox血清疫学

    Grant-in-Aid for Scientific Research(C)  2026

  • 潜在的感染拡大を明らかにするハイリスク集団におけるMpox血清疫学

    Grant-in-Aid for Scientific Research(C)  2025

  • 潜在的感染拡大を明らかにするハイリスク集団におけるMpox血清疫学

    Grant-in-Aid for Scientific Research(C)  2024

Charge of on-campus class subject

  • 発表表現演習

    2025   Intensive lecture   Graduate school

  • 研究指導

    2025   Intensive lecture   Graduate school

  • ウイルス学特論

    2025   Intensive lecture   Graduate school

  • ウイルス学演習

    2025   Intensive lecture   Graduate school

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