2024/02/01 更新

写真a

ゴトウ ヒロユキ
後藤 寛之
GOTO HIROYUKI
担当
大学院医学研究科 臨床医科学専攻 講師
医学部 医学科
職名
講師
所属
医学研究院

担当・職階

  • 大学院医学研究科 臨床医科学専攻 

    講師  2023年07月 - 継続中

  • 医学部 医学科 

    講師  2023年07月 - 継続中

取得学位

  • 医学博士 ( 鳥取大学 )

研究分野

  • ライフサイエンス / 皮膚科学

所属学協会

  • 日本癌学会

  • 日本皮膚外科学会

  • 日本皮膚悪性腫瘍学会

  • 日本皮膚病理組織学会

  • 日本皮膚科学会

委員歴(学外)

  • メラノーマ診療ガイドライン委員   日本皮膚科学会  

    2023年04月 - 継続中 

受賞歴

  • The Journal of Dermatology Top Reviewer Award

    日本皮膚科学会  

職務経歴(学外)

  • 大阪公立大学医学部皮膚病態学

    2023年04月 - 継続中

  • 鳥取県立中央病院

    2022年04月 - 2023年03月

  • 鳥取大学医学部皮膚科

    2016年07月 - 2022年03月

論文

  • Dermoscopic findings in two cases of keratoacanthoma en plaque 査読

    Inoue M.

    Journal of Dermatology   50 ( 12 )   e409 - e410   2023年08月( ISSN:03852407

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    国際・国内誌:国際誌  

    DOI: 10.1111/1346-8138.16915

    PubMed

  • 陰嚢の瘻孔が診断の契機となったクローン病の1例

    池田 彩乃, 後藤 寛之, 吉田 雄一

    西日本皮膚科   85 ( 4 )   281 - 283   2023年08月( ISSN:0386-9784

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    24歳,男性。初診の5ヵ月前に腹痛と発熱を生じ,胃腸炎と診断されたが,抗生剤内服で軽快した。初診の4ヵ月前に陰嚢の硬結に気がついた。発熱・陰嚢腫大を伴うようになり,切開排膿・抗生剤による治療を行われたが,症状を繰り返したため,当科へ紹介された。左陰茎基部に腫脹と皮下硬結があり,圧迫にて排膿がみられた。陰嚢の瘻孔を壁ごと全切除する目的に全身麻酔下で手術を行ったが,瘻孔は背側(肛門方向)の深部まで続いており,広範囲の死腔と不良肉芽を認めた。腹部CTでは陰茎根部左側から肛門管左側にかけて軟部影がみられた。また,創部培養からは腸内細菌が検出された。病理組織学的に非乾酪性類上皮細胞肉芽腫がみられなかったが,陰嚢の瘻孔が腸管と連続している可能性を考え,消化器内科・外科へ紹介し,クローン病(以下CD)と診断した。CDの皮膚病変は多彩であり,難治性・再発性の瘻孔ではCDに伴う痔瘻の可能性を考慮する必要がある。(著者抄録)

  • Eccrine Angiomatous Hamartoma Occurring on the Nail Bed(タイトル和訳中)

    Notsu Hiroshi, Goto Hiroyuki, Tani Naomi, Sugita Kazunari

    Yonago Acta Medica   66 ( 3 )   380 - 381   2023年08月( ISSN:0513-5710

  • Eccrine Angiomatous Hamartoma Occurring on the Nail Bed. 査読

    Hiroshi Notsu, Hiroyuki Goto, Naomi Tani, Kazunari Sugita

    Yonago acta medica   66 ( 3 )   380 - 381   2023年08月

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    国際・国内誌:国内誌  

    A 71-year-old woman was referred to our clinic with a 2-month history of pain and exudate from her right first toe. Physical examination revealed a subungual nodule that elevated the nail plate and produced distal onycholysis. We performed onychectomy and removed the nodule. A histopathological specimen from the nodule showed hyperkeratosis and acanthosis in the epidermis, papillomatosis and dilated vessels in the superficial dermis, and aggregation of eccrine glands in the mid-dermis. Based on these findings, a diagnosis of eccrine angiomatous hamartoma (EAH) was made. EAH is a rare cutaneous hamartoma that is histologically characterized by proliferation of eccrine glands and vascular components. To our knowledge, EAH occurring in the subungual region has not been reported. The pathogenesis of acquired EAH has not been completely elucidated, but several cases have been reported to be caused by external stimuli. Although the subungual area generally has no sweat glands, our case suggests that a traumatic stimulus can induce EAH anywhere including regions where sweat glands are normally not found.

    DOI: 10.33160/yam.2023.08.004

    PubMed

  • Porocarcinoma Concurrent with Psoriasis Vulgaris: The First Report(タイトル和訳中)

    Ehara Yuko, Goto Hiroyuki, Ozaki Kanae, Yoshida Yuichi

    Yonago Acta Medica   66 ( 3 )   382 - 384   2023年08月( ISSN:0513-5710

  • Porocarcinoma Concurrent with Psoriasis Vulgaris: The First Report. 査読

    Yuko Ehara, Hiroyuki Goto, Kanae Ozaki, Yuichi Yoshida

    Yonago acta medica   66 ( 3 )   382 - 384   2023年08月

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    国際・国内誌:国内誌  

    Psoriasis is a common chronical inflammatory skin disease with a prevalence of 2%-4% worldwide. In contrast, porocarcinoma is a relatively rare cutaneous neoplasm and an associated localization of both lesions is rare. Here, we describe the first case of porocarcinoma in a patient with psoriasis. A 71-year-old Japanese man was referred to our clinic for evaluation of nodule within a keratotic plaque of 20-years history on his leg. Histopathological examination showed that the plaque revealed acanthosis with regular elongation of rete ridges, agranulosis and the presence of Munro microabscesses. In contrast, massive proliferation of atypical poroid cells and a few cuticular cells in the dermis were seen in the nodule. We speculated that it is likely the porocarcinoma was caused by the elevated risk of skin cancer due to chronic inflammatory process of psoriasis itself in our patient.

    DOI: 10.33160/yam.2023.08.005

    PubMed

  • Ulcerative Tumour on the Frontal Scalp: A Quiz 査読

    Koide M.

    Acta Dermato-Venereologica   103   adv13424   2023年07月( ISSN:00015555

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    掲載種別:研究論文(学術雑誌)   国際・国内誌:国際誌  

    DOI: 10.2340/actadv.v103.13424

    PubMed

  • Ultrastructural and morphological analysis during progression of Bowen disease reveals a complex interplay between hyperkeratosis, cytokeratin expression, host immunity and amyloid deposition. 査読

    Hiroyuki Goto, Kazunari Sugita, Takashi Horie, Osamu Yamamoto

    European journal of dermatology : EJD   33 ( 3 )   207 - 217   2023年06月

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    担当区分:筆頭著者   掲載種別:研究論文(学術雑誌)   国際・国内誌:国際誌  

    BACKGROUND: Bowen disease, one of the common skin cancers, is defined as squamous cell carcinoma in situ, characterized by atypical keratinocytes occupying the full thickness of the epidermis, and predominantly occurs on sun-protected skin. There is no existing data on the impact of tumour and immune cell interactions or cytokeratin expression on the pathology of Bowen disease. OBJECTIVES: We analysed dynamic changes in cytokeratin expression and immune cell composition during the development and progression of Bowen disease. MATERIALS & METHODS: Analysis was performed using immunohistochemistry and electron microscopy for samples from 140 patients with Bowen disease and 20 patients with invasive squamous cell carcinoma. We evaluated cytokeratin expression, the number of infiltrating immune cells and amyloid deposition by immunohistochemistry, and the ultrastructural relationship between tumour cells and immune cells by electron microscopy. RESULTS: The results showed that the expression of CK14 is associated with tumour progression, keratotic status and amyloid deposition and that the expression of CK10 is associated with accumulation of immune cells in Bowen disease. The findings of electron microscopy indicated repeated battles involving immune cells in response to tumour invasion. CONCLUSION: The expression of cytokeratins, hyperkeratosis, inflammatory infiltration and amyloid deposition are useful findings indicating the "stage" in Bowen disease.

    DOI: 10.1684/ejd.2023.4497

    PubMed

  • Gorlin Syndrome and Cowden Syndrome.

    Goto H, Tateishi C, Tsuruta D

    The Keio Journal of Medicine   advpub ( 0 )   2023年( ISSN:00229717

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    担当区分:筆頭著者   掲載種別:研究論文(学術雑誌)   国際・国内誌:国内誌  

    DOI: 10.2302/kjm.2023-0010-ir

    PubMed

  • First Case of Allochronic Onset of Two Primary Dermatofibrosarcoma Protuberans Lesions Proved by COL1A1-PDGFB Fusion Gene Analysis. 査読

    Ayano Ikeda, Masanori Hisaoka, Hiroyuki Goto, Yuichi Yoshida, Osamu Yamamoto

    Acta dermato-venereologica   102   adv00822   2022年11月

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    掲載種別:研究論文(学術雑誌)   国際・国内誌:国際誌  

    DOI: 10.2340/actadv.v102.2421

    PubMed

  • Current Treatment Options for Cutaneous Adnexal Malignancies. 査読

    Hiroyuki Goto

    Current treatment options in oncology   23 ( 5 )   736 - 748   2022年05月

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    担当区分:筆頭著者   掲載種別:研究論文(学術雑誌)   国際・国内誌:国際誌  

    Cutaneous adnexal malignancies include various types of malignant tumors that show differentiation of cutaneous appendages. They can be classified into sweat gland, hair follicle, and sebaceous gland differentiations. All types of cutaneous adnexal tumors are rare and standard treatment options based on valid evidence have not been established. Although prognosis differs depending on the type of cutaneous adnexal malignancy, surgery is the mainstay of treatment. In surgical treatment, an adequate surgical margin is unclear for wide local excision. Mohs micrographic is a better option than wide local excision in terms of margin control and cosmetic outcome because the face, head, and neck are favorable sites for some cutaneous adnexal malignancies. There has been no randomized trial of radiation therapy and chemotherapy for any cutaneous adnexal malignancies. Radiation therapy should be considered if the tumor cannot be removed surgically. Chemotherapy is one of the options for metastatic cases in some types of cutaneous adnexal malignancies, but evidence of the effectiveness of chemotherapy is lacking. Recent studies have revealed genetic mutations in this field, and target therapy and immunotherapy may be promising treatment options for unresectable cutaneous adnexal malignancies in the future.

    DOI: 10.1007/s11864-022-00971-3

    PubMed

  • Thyroid-shaped iododerma on the neck. 査読

    Reiko Tsutsumi, Yuichi Yoshida, Hiroyuki Goto, Osamu Yamamoto

    Contact dermatitis   86 ( 2 )   132 - 134   2022年02月

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    掲載種別:研究論文(学術雑誌)   国際・国内誌:国際誌  

    DOI: 10.1111/cod.13991

    PubMed

  • Adult-onset Still's Disease Secondary to Cytophagic Histiocytic Panniculitis. 査読

    Ai Yoshida, Kazunari Sugita, Nanako Yamada, Hiroyuki Goto, Osamu Yamamoto

    Acta dermato-venereologica   102   adv00639   2022年01月

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    掲載種別:研究論文(学術雑誌)   国際・国内誌:国際誌  

    DOI: 10.2340/actadv.v101.568

    PubMed

  • Co-occurrence of Necrobiosis Lipoidica, Sarcoidosis and Lichen Planus. 査読

    Nanako Shiroma, Hiroyuki Goto, Naomi Tani, Kazunari Sugita, Osamu Yamamoto

    Indian journal of dermatology   67 ( 5 )   594 - 595   2022年

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    担当区分:責任著者   掲載種別:研究論文(学術雑誌)   国際・国内誌:国際誌  

    DOI: 10.4103/ijd.ijd_1039_20

    PubMed

  • Thymic Carcinoma in a Patient with Melanoma. 査読

    Hiroyuki Goto, Yuichi Yoshida, Hisashi Suyama, Masahisa Shindo, Ken Miwa, Hiroshige Nakamura, Osamu Yamamoto

    Indian journal of dermatology   67 ( 4 )   482 - 482   2022年

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    担当区分:筆頭著者   掲載種別:研究論文(学術雑誌)   国際・国内誌:国際誌  

    DOI: 10.4103/ijd.IJD_15_19

    PubMed

  • Late contralateral lymph node metastasis of basal cell carcinoma on the scrotum. 査読

    Hiroyuki Goto, Yuichi Yoshida, Osamu Yamamoto

    European journal of dermatology : EJD   31 ( 5 )   654 - 655   2021年10月

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    担当区分:筆頭著者   掲載種別:研究論文(学術雑誌)   国際・国内誌:国際誌  

    DOI: 10.1684/ejd.2021.4130

    PubMed

  • Bowen's disease occurring on a reticulated acanthoma with sebaceous differentiation: possible malignant transformation. 査読

    Ai Yoshida, Yuichi Yoshida, Hiroyuki Goto, Osamu Yamamoto

    European journal of dermatology : EJD   2021年08月

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    掲載種別:研究論文(学術雑誌)   国際・国内誌:国際誌  

    DOI: 10.1684/ejd.2021.4088

    PubMed

  • センチネルリンパ節生検陽性後のメラノーマ患者における超音波検査によるリンパ節転移検出の限界(Limitation of Using Ultrasonography After Positive Sentinel Lymph Node Biopsy in a Patient with Melanoma in the Detection of Lymph Node Metastasis)

    Goto Hiroyuki, Sugita Kazunari, Yamamoto Osamu

    Yonago Acta Medica   64 ( 3 )   315 - 317   2021年08月( ISSN:0513-5710

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    症例は74歳女性で、左足底の末端黒子型黒色腫と診断され、2年前に完全切除およびセンチネルリンパ節生検が施行されていた。センチネルリンパ節生検陽性であったが、患者は完全リンパ節郭清を拒否していた。ニボルマブによる1年間の術後補助療法が施行された。術後補助療法終了後4ヵ月で、超音波検査にて鼠径部リンパ節に異常を認めた。リンパ節生検を施行したところ、切除したリンパ節は黒色であり、病理組織学的には転移したメラノーマ細胞で占められていた。また、超音波検査にて正常な外観を呈していた隣接するリンパ節も黒色であり、病理組織学的には転移病巣であることが示された。骨盤内リンパ節にも僅かに腫脹が認められたが、患者が鼠径・骨盤内リンパ節郭清を拒否したため、ペムブロリズマブ投与が行われた。ペムブロリズマブ投与開始1年後に遠隔転移は認められなかった。

  • Limitation of Using Ultrasonography After Positive Sentinel Lymph Node Biopsy in a Patient with Melanoma in the Detection of Lymph Node Metastasis. 査読

    Hiroyuki Goto, Kazunari Sugita, Osamu Yamamoto

    Yonago acta medica   64 ( 3 )   315 - 317   2021年08月

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    担当区分:筆頭著者   国際・国内誌:国内誌  

    Recent studies have shown that complete lymph node dissection (CLND) performed immediately did not improve the overall survival in patients with sentinel lymph node (LN)-positive melanoma. According to these results, nodal observation with ultrasonography becomes standard. However, it still has some limitations for detection of metastatic LNs. A 74-year-old woman was diagnosed with acral lentiginous melanoma of her left sole. The sentinel LN was positive for metastasis, but she refused CLND. Sixteen months after operation, ultrasonography showed an abnormal LN in the inguinal region. There was no other abnormal LNs around the LN. We resected the abnormal LN. The resected LN was black in color, and the adjacent LN that showed normal appearance in ultrasonography was also black. A recent study showed only 6.6% sensitivity in preoperative ultrasonographic detection of metastatic melanoma in a LN. We should keep in mind the limitation of ultrasonography for detection of a metastatic LN.

    DOI: 10.33160/yam.2021.08.008

    PubMed

  • Interstitial granuloma after interferon-gamma and narrowband UVB therapy in a patient with mycosis fungoides: Immunological and histopathological considerations. 査読

    Hiroyuki Goto, Kazunari Sugita, Osamu Yamamoto

    Journal of cutaneous pathology   48 ( 5 )   689 - 693   2021年05月

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    担当区分:筆頭著者   国際・国内誌:国際誌  

    In mycosis fungoides (MF), cutaneous granuloma formation is unusual. Furthermore, MF showing interstitial granuloma, a rare type, after combination therapy with interferon-gamma (IFN-γ) and narrowband UVB (nbUVB) has not been previously reported. A 77-year-old man was referred to our hospital with a 2-month history of erythroderma. Biopsied specimens revealed infiltration of atypical lymphocytes and eosinophils. A diagnosis of an erythrodermic variant of MF was made. He was treated with combination therapy of IFN-γ and nbUVB. After the therapy, papules newly appeared and a histopathological specimen revealed interstitial granuloma. There were several CXCR3-positive cells around the granuloma. We speculated that the combination therapy made T-helper 1 cells migrate to the cutaneous lesion and resulted in the granuloma formation. Furthermore, judging from the disappearance of elastic fibers around the interstitial granuloma, we considered that IFN-γ may induce the infiltration of histiocytes interstitially after damage of elastic fibers caused by nbUVB therapy, and both IFN-γ and nbUVB may thus play an important role in the histogenesis. Not only histopathology but also immunological observations are needed to elucidate the mechanisms underlying the development of different types of granuloma in MF.

    DOI: 10.1111/cup.13960

    PubMed

  • 不完全なシェーグレン症候群に柵状好中球性肉芽腫性皮膚炎、間質性肉芽腫性皮膚炎、IgA血管炎を合併した1症例(Palisaded neutrophilic granulomatous dermatitis, interstitial granulomatous dermatitis and IgA vasculitis associated with incomplete Sjoegren's syndrome)

    Sugioka Kyoko, Goto Hiroyuki, Sugita Kazunari, Habe Koji, Yamanaka Keiichi, Yamamoto Osamu

    The Journal of Dermatology   48 ( 4 )   556 - 558   2021年04月( ISSN:0385-2407

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    症例は81歳女性で、4ヵ月間続いている全身のそう痒性紅斑を主訴に当院へ紹介された。間質性肺炎と不完全なシェーグレン症候群(唾液腺造影所見と口唇生検所見が診断基準に合致せず)の病歴があり、3年間にわたり経過観察が続けられていた。診察では全身の紅斑に加え、両肘・両膝に赤色の局面と結節を、下肢に紫斑を認めた。赤色局面の生検では肉芽腫が形成されている様子が示された。その肉芽腫の中心部には好中球浸潤と膠原線維変性がみられ、周辺部には間質性肉芽腫といわゆる「floating sign」が観察された。Elastica van Gieson染色では、肉芽腫周囲に分布する多核巨細胞が弾性線維を貪食している所見が認められた。また小血管の壁にはIgM、IgA、C3が沈着していることも直接蛍光抗体法から明らかにされた。こうした所見から、本症例は不完全なシェーグレン症候群を背景とする、柵状好中球性肉芽腫性皮膚炎(palisaded neutrophilic granulomatous dermatitis)、間質性肉芽腫性皮膚炎、IgA血管炎のオーバーラップ症候群と診断した。

  • Palisaded neutrophilic granulomatous dermatitis, interstitial granulomatous dermatitis and IgA vasculitis associated with incomplete Sjögren's syndrome. 査読

    Kyoko Sugioka, Hiroyuki Goto, Kazunari Sugita, Koji Habe, Keiichi Yamanaka, Osamu Yamamoto

    The Journal of dermatology   48 ( 4 )   556 - 558   2021年04月

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    担当区分:責任著者   掲載種別:研究論文(学術雑誌)   国際・国内誌:国際誌  

    Palisaded neutrophilic granulomatous dermatitis (PNGD) and interstitial granulomatous dermatitis (IGD) are rare granulomatous disorders. Differential diagnosis of PNGD and IGD is often difficult, but both conditions occasionally exist together. We report here the first potential overlapping case of PNGD, IGD, and Immunoglobulin A (IgA) vasculitis associated with incomplete Sjögren's syndrome. An 81-year-old woman who had been followed up for interstitial pneumonia and incomplete Sjögren's syndrome was referred to our clinic. She had multiple erythematous plaques and nodules on her entire body and purpura on her legs. Biopsied specimens showed granuloma formation with neutrophilic infiltration and degenerated collagen fibers in the center. In addition, interstitial granuloma and so-called "floating sign" in the periphery and leukocytoclastic vasculitis were noted. Elastica-van Gieson staining revealed phagocytosis of elastic fibers by multinucleated giant cells around the granulomas. Direct immunofluorescence showed IgM, IgA, and C3 deposition in vascular walls. We made a diagnosis of an overlap syndrome of PNGD, IGD, and IgA vasculitis in a background of incomplete Sjögren's syndrome. No such case has been previously reported. The pathogenesis of the present case may be associated with Sjögren's syndrome.

    DOI: 10.1111/1346-8138.15738

    PubMed

  • Expression of Programmed Death-Ligand 1 and Programmed Death-1 in Patients with Extramammary Paget's Disease. 査読

    Hiroyuki Goto, Kazunari Sugita, Osamu Yamamoto

    Indian journal of dermatology   66 ( 2 )   169 - 173   2021年

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    担当区分:筆頭著者   掲載種別:研究論文(学術雑誌)   国際・国内誌:国際誌  

    BACKGROUND: Extramammary Paget's disease (EMPD) is a rare skin cancer and sometimes has fatal prognosis. For progressive cases, therapeutic options are limited. In recent years, treatment with an anti-programmed death-1 (PD-1) antibody has improved the prognosis of various malignancies. In addition, correlations between PD-ligand 1 (PD-L1) expression in tumor cells and favorable responses to anti-PD-1 therapy have been reported for several cancers. There have been a few case series of analysis of PD-L1 expression in patients with EMPD. AIMS: The purpose of this study was to investigate the relationship between the EMPD and PD-L1/PD-1 expression in Japanese EMPD patients. MATERIALS AND METHODS: We investigated 39 patients with EMPD by immunohistochemical staining of PD-L1 and PD-1. We counted the number of tumor cells that were positive for PD-L1 and the number of tumor-infiltrating mononuclear cells (TIMCs) that were positive for PD-L1 and PD-1. We also analyzed correlations between the expression of PD-L1 and PD-1 in EMPD and patients' characteristics. RESULTS: We found that none of the Paget's cells expressed PD-L1. All of the specimens contained TIMCs, and some of the TIMCs expressed PD-L1 and PD-1. However, there was no correlation between the expression of PD-L1/PD-1 in TIMCs and patients' characteristics. CONCLUSION: Although tumor cells did not express PD-L1 and the expression of PD-L1/PD-1 in TIMCs did not correlate with patients' characteristics, future clinical studies should be carried out to explore another immune escape pathway in EMPD.

    DOI: 10.4103/ijd.IJD_341_18

    PubMed

  • Nodules on the Knee in a Child: A Quiz. 査読

    Hiroyuki Goto, Kazunari Sugita, Osamu Yamamoto

    Acta dermato-venereologica   100 ( 15 )   adv00231   2020年08月

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    担当区分:筆頭著者   掲載種別:研究論文(学術雑誌)   国際・国内誌:国際誌  

    is missing (Quiz).

    DOI: 10.2340/00015555-3580

    PubMed

  • Clinicopathological features of polypoid basal cell carcinoma: the first study in Japan. 査読

    Koji Adachi, Yuichi Yoshida, Hiroyuki Goto, Hisashi Noma, Osamu Yamamoto

    European journal of dermatology : EJD   30 ( 4 )   433 - 435   2020年08月

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    掲載種別:研究論文(学術雑誌)   国際・国内誌:国際誌  

    DOI: 10.1684/ejd.2020.3806

    PubMed

  • Bullous pemphigoid exacerbation associated with reactivation of herpes simplex virus infection. 査読

    Naomi Tani, Yuichi Yoshida, Hiroyuki Goto, Norito Ishii, Takashi Hashimoto, Osamu Yamamoto

    European journal of dermatology : EJD   30 ( 4 )   429 - 431   2020年08月

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    掲載種別:研究論文(学術雑誌)   国際・国内誌:国際誌  

    DOI: 10.1684/ejd.2020.3809

    PubMed

  • Implication of Perifollicular Clusters and Folliculotropic Distribution of Dendritic Cells in the Pathogenesis of Seborrhoeic Dermatitis. 査読

    Ayako Ito, Kazunari Sugita, Hiroyuki Goto, Osamu Yamamoto

    Acta dermato-venereologica   100 ( 13 )   adv00183   2020年06月

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    掲載種別:研究論文(学術雑誌)   国際・国内誌:国際誌  

    The pathogenesis of seborrhoeic dermatitis is controversial and remains unclear. Malassezia is considered to be a commensal fungi and is found not only in the stratum corneum but also in hair follicles. It is an important pathogenic factor in seborrhoeic dermatitis. The aim of this study was to clarify the pathogenesis of seborrhoeic dermatitis, morphologically, through comparison with psoriasis vulgaris. Fifteen cases of seborrhoeic dermatitis, 7 of psoriasis, and 6 of normal skin were examined using routine histopathology, immunohistochemistry, and electron microscopy. Macrophages were found to be diffusely distributed in the upper dermis of seborrhoeic dermatitis and psoriasis. In contrast, a significant increase in the number of dendritic cells in the follicular epithelium and dendritic cell clusters in the perifollicular dermis were found only in seborrhoeic dermatitis. Ultrastructural examination of the clusters demonstrated that dendritic cells interacted with lymphocytes, macrophages, and other dendritic cells. In conclusion, folliculotropic distribution of dendritic cells as well as dendritic cell-immune cell clusters play an important role in the pathogenesis of seborrhoeic dermatitis.

    DOI: 10.2340/00015555-3519

    PubMed

  • Ulcerative Pigmented Nodules on a Postoperative Scar: A Quiz. 査読

    Hiroyuki Goto, Yuichi Yoshida, Osamu Yamamoto

    Acta dermato-venereologica   100 ( 13 )   adv00177   2020年06月

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    担当区分:筆頭著者   掲載種別:研究論文(学術雑誌)   国際・国内誌:国際誌  

    DOI: 10.2340/00015555-3534

    PubMed

  • Seborrheic inclusion cyst with sebaceous gland involvement: what does it mean? 査読

    Yuichi Yoshida, Hiroyuki Goto, Osamu Yamamoto

    European journal of dermatology : EJD   2020年04月

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    掲載種別:研究論文(学術雑誌)   国際・国内誌:国際誌  

    DOI: 10.1684/ejd.2020.3725

    PubMed

  • 【よくみる疾患 common skin disease】皮膚原発肛囲乳房外Paget病 異時性に陰嚢にも多発病変を生じた症例

    後藤 寛之

    皮膚病診療   42 ( 4 )   334 - 337   2020年04月( ISSN:0387-7531

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    <文献概要>症例のポイント ・皮膚原発肛囲乳房外Paget病を経験した.・大腸内視鏡検査,PET-CTおよび免役組織化学染色で皮膚原発であることを確認した.・異時性に陰嚢部にも乳房外Paget病を発症した.

  • Sarcomatoid squamous cell carcinoma with intermediary characteristics of squamous cell carcinoma and atypical fibroxanthoma. 査読

    Hiroyuki Goto, Ayako Ito, Masahisa Shindo, Osamu Yamamoto

    The Journal of dermatology   47 ( 2 )   e41-e43   2020年02月

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    担当区分:筆頭著者   国際・国内誌:国際誌  

    DOI: 10.1111/1346-8138.15192

    PubMed

  • Histopathological pattern of recurrent ossifying fibromyxoid tumour showing a soft tissue metastasis after repeated local recurrence. 査読

    Akiko Okita, Yosuke Nakayama, Ayako Ito, Kazunari Sugita, Hiroyuki Goto, Osamu Yamamoto

    The Australasian journal of dermatology   61 ( 1 )   e117-e119   2020年02月

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    国際・国内誌:国際誌  

    DOI: 10.1111/ajd.13140

    PubMed

  • Expression of Programmed Death-Ligand 1 in Cutaneous Squamous Cell Carcinoma Arising in Sun-Exposed and Nonsun-Exposed Skin. 査読

    Hiroyuki Goto, Kazunari Sugita, Osamu Yamamoto

    Indian journal of dermatology   65 ( 6 )   506 - 509   2020年

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    担当区分:筆頭著者   掲載種別:研究論文(学術雑誌)   国際・国内誌:国際誌  

    BACKGROUND: A recent clinical trial has shown the efficacy of an anti-programmed death-1 (PD-1) antibody against advanced squamous cell carcinoma (SCC). The expression of PD-ligand 1 (PD-L1) in tumor cells correlates with a favorable response to anti-PD-1 therapy in various malignancies. In recent studies, it has been shown that SCC frequently expresses PD-L1. However, there has been no previous study focusing on the difference in PD-L1 expression between SCC in sun-exposed skin and that in nonsun-exposed areas. AIMS: The purpose of this study was to investigate the relationship between sun-exposure status and PD-L1 expression in patients with SCC. MATERIALS AND METHODS: We investigated 80 patients with SCC (40 patients with SCC in sun-exposed skin and 40 patients with SCC in nonsun-exposed skin) by immunohistochemical staining for PD-L1. Fisher's exact test was used for statistical analyses of the differences between the two groups. RESULTS: Patients with SCC in sun-exposed skin showed a significantly higher expression level of PD-L1 in tumor cells than did patients with SCC in nonsun-exposed skin (P = 0.0133). CONCLUSIONS: We found that the expression level of PD-L1 in patients with SCC in sun-exposed skin was higher than in patients with SCC in nonsun-exposed skin. Practical data are needed for appropriate applications of new therapeutic options for SCC.

    DOI: 10.4103/ijd.IJD_187_19

    PubMed

  • Human type 2 innate lymphoid cells disrupt skin keratinocyte tight junction barrier by IL-13. 査読

    Kazunari Sugita, Can Altunbulakli, Hideaki Morita, Atsuko Sugita, Terufumi Kubo, Ryoko Kimura, Hiroyuki Goto, Osamu Yamamoto, Beate Rückert, Mübeccel Akdis, Cezmi A Akdis

    Allergy   74 ( 12 )   2534 - 2537   2019年12月

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    国際・国内誌:国際誌  

    DOI: 10.1111/all.13935

    PubMed

  • Localized Pegfilgrastim-induced Neutrophilic Dermatosis with Tissue G-CSF Expression: A Mimicker of Sweet's Syndrome. 査読

    Toshio Ichiki, Kazunari Sugita, Hiroyuki Goto, Masahisa Shindo, Osamu Yamamoto

    Acta dermato-venereologica   99 ( 7 )   685 - 686   2019年06月

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    掲載種別:研究論文(学術雑誌)   国際・国内誌:国際誌  

    DOI: 10.2340/00015555-3170

    PubMed

  • Granuloma formation clinically presenting as erythroderma in a patient with peripheral T-cell lymphoma. 査読

    Hiroyuki Goto, Kazunari Sugita, Masahisa Shindo, Osamu Yamamoto

    European journal of dermatology : EJD   29 ( 3 )   324 - 326   2019年06月

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    担当区分:筆頭著者   国際・国内誌:国際誌  

    DOI: 10.1684/ejd.2019.3544

    PubMed

  • Multiple microvenular hemangioma eruptively concentrated on an adult face: Importance of clinical differential diagnosis. 査読

    Yuko Ehara, Kazunari Sugita, Hiroyuki Goto, Osamu Yamamoto

    The Journal of dermatology   46 ( 6 )   e205-e206   2019年06月

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    国際・国内誌:国際誌  

    DOI: 10.1111/1346-8138.14767

    PubMed

  • Unusual dermoscopic feature of a melanocytic naevus on load bearing plantar skin never pressured because of cerebral palsy. 査読

    Ayako Ito, Kazunari Sugita, Hiroyuki Goto, Osamu Yamamoto

    The Australasian journal of dermatology   60 ( 2 )   150 - 151   2019年05月

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    国際・国内誌:国際誌  

    DOI: 10.1111/ajd.12953

    PubMed

  • Symptoms of and Palliative Treatment for Unresectable Skin Cancer. 査読

    Hiroyuki Goto, Yoshio Kiyohara, Masahisa Shindo, Osamu Yamamoto

    Current treatment options in oncology   20 ( 4 )   34 - 34   2019年03月

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    担当区分:筆頭著者   掲載種別:研究論文(学術雑誌)   国際・国内誌:国際誌  

    OPINION STATEMENT: The symptom prevalence in patients with advanced cancer depends on the type of primary cancer, and the palliative treatment varies according to the nature of the primary cancer. Palliative treatment for unresectable skin cancer has not been fully discussed. Patients with unresectable skin cancer sometimes show the primary lesion in the skin and metastases to the lung, skin, liver, and bone. Pain, anorexia, and dyspnea commonly occur in such patients, and bleeding, exudate, and offensive odor are characteristically observed. For the last three symptoms, surgery and radiation are effective therapeutic options, and cryotherapy, Mohs' chemosurgery, electrochemotherapy, and some topical ointments and dressing materials are also additional options. For pain due to bone metastasis, pharmacotherapy with opioid and/or non-opioid agents is the most basic treatment, and radiation and bisphosphonate therapies are other options. For dyspnea, which is an intractable and uncomfortable symptom, morphine and oxygen play a leading role in treatment. Red blood cell transfusions may be effective for some patients with dyspnea induced by anemia. Nutritional supports and pharmacotherapy are therapeutic options for anorexia. As nutritional supports, enteral nutrition is better than parenteral nutrition. There is some evidence of progestins and corticosteroids having supportive effects for anorexia. Dermatologic oncologists should be skilled with symptom managements to maintain the quality of life in patients with unresectable skin cancer and their families.

    DOI: 10.1007/s11864-019-0626-5

    PubMed

  • A small nodule on the auricle. 査読

    R Kimura, K Sugita, H Goto, O Yamamoto

    Clinical and experimental dermatology   44 ( 2 )   203 - 205   2019年03月

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    掲載種別:研究論文(学術雑誌)   国際・国内誌:国際誌  

    DOI: 10.1111/ced.13636

    PubMed

  • Cytophagic Histiocytic Panniculitis Associated with Myelodysplastic Syndrome. 査読

    Ryoko Kimura, Kazunari Sugita, Hiroyuki Goto, Osamu Yamamoto

    Acta dermato-venereologica   99 ( 1 )   97 - 98   2019年01月

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    掲載種別:研究論文(学術雑誌)   国際・国内誌:国際誌  

    DOI: 10.2340/00015555-3043

    PubMed

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