Updated on 2026/07/24

写真a

 
UEMURA NORIHITO
 
Organization
Graduate School of Medicine Department of Basic Medical Science Lecturer
School of Medicine Department of Medical Science
Title
Lecturer
Affiliation
Institute of Medcine

Position

  • Graduate School of Medicine Department of Basic Medical Science 

    Lecturer  2024.10 - Now

  • School of Medicine Department of Medical Science 

    Lecturer  2024.10 - Now

Degree

  • 博士（医学） （ Kyoto University ）

Research Areas

  • Life Science / Pathophysiologic neuroscience

  • Life Science / Neurology

Research Interests

  • alpha-synuclein

  • Parkinson's disease

  • Dementia with Lewy bodies

  • Multiple system atrophy

Professional Memberships

  • 日本自律神経学会

    2023.06 - Now

  • 日本神経科学学会

    2012.06 - Now

  • 日本神経学会

    2007.07 - Now

  • 日本内科学会

    2005.12 - Now

Awards

  • 奨励賞

    2025.07   日本神経科学学会  

Job Career (off-campus)

  • 京都大学大学院医学研究科   多系統萎縮症治療学講座   非常勤研究員

    2024.10 - Now

  • Osaka Metropolitan University

    2024.10 - Now

  • Graduate school of medicine, Kyoto University   Department of Therapeutics for Multiple System Atrophy   Senior Lecturer

    2023.10 - Now

Papers

  • Evaluation of a commercial AI-assisted cell counting software for dopaminergic neurons across species Invited Reviewed

    Ken Kunugitani, Masanori Sawamura, Tomoyuki Taguchi, Tetsuya Hirato, Norihito Uemura, Takashi Ayaki, Etsuro Nakanishi, Hodaka Yamakado, Tomoyuki Ishimoto, Hirotaka Onoe, Tadashi Isa, Riki Matsumoto, Ryosuke Takahashi

    PLOS One   21 ( 3 )   e0344621 - e0344621   2026.03（ eISSN:1932-6203 ）

    　More details

    Publishing type：Research paper (scientific journal)  

    Quantification of dopaminergic neurons in the substantia nigra pars compacta (SNc) of animal models is important for understanding the pathogenesis of Parkinson’s disease (PD). However, conventional manual cell counting method requires the time and effort, and has limited reproducibility due to inter- and intra-examiner variability. Here, we demonstrate that a commercially available convolutional neural network–based artificial intelligence (AI) counting method (TruAI, OLYMPUS, Tokyo, Japan) enables robust and reproducible quantification of TH-positive dopaminergic neurons in mouse, marmoset, and human SNc samples when compared with conventional manual counting. AI-based counting showed a strong correlation with manual counting across mouse, marmoset, and human samples. Good agreement between AI-based and manual counting was observed in mouse and marmoset samples, supporting the applicability of this approach for cross-species quantification of dopaminergic neurons. In the mouse model treated with α-syn preformed fibrils (PFFs), AI-based counting detected a significant reduction in TH-positive neurons consistent with expert manual counting. Non-experts exhibited greater intra-examiner variability than an expert, indicating that the reliability of manual counting depends on experience. Overall, AI-based quantification provides a robust and objective approach for TH-positive cell counting and may improve reproducibility in dopaminergic neuron analysis, particularly for non-expert users and cross-species studies of PD.

    DOI： 10.1371/journal.pone.0344621

    PubMed

  • Perampanel Blocks Transsynaptic α-Synuclein Propagation and Neurodegeneration in a Mouse Model of Lewy Body Disease Invited Reviewed

    Ueda J.

    Movement Disorders   2026（ ISSN:08853185 ）

    　More details

    Authorship：Lead author,　Last author,　Corresponding author  

    DOI： 10.1002/mds.70191

    PubMed

  • Fibril-seeded animal models of synucleinopathies: Pathological mechanisms, disease modeling, and therapeutic implications Invited Reviewed

    Norihito Uemura

    Neuroscience Research   216   104905 - 104905   2025.07（ ISSN:0168-0102 ）

    　More details

    Authorship：Lead author,　Last author,　Corresponding author   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.neures.2025.04.008

    PubMed

  • The Gut-Brain Axis Based on α-Synuclein Propagation-Clinical, Neuropathological, and Experimental Evidence. Invited Reviewed

    Ryosuke Takahashi, Hodaka Yamakado, Norihito Uemura, Tomoyuki Taguchi, Jun Ueda

    International journal of molecular sciences   26 ( 9 )   2025.04（ ISSN:16616596 ）

    　More details

    Publishing type：Research paper (scientific journal)   International / domestic magazine：International journal  

    The cytopathological hallmark of Parkinson's disease (PD) is a neuronal cytoplasmic inclusion called Lewy body (LB). Lewy bodies are composed of alpha-synuclein (aSyn), a 140 aa protein that is predominantly expressed in the presynaptic terminal and which is implicated in neurotransmitter release. Recently, aSyn was found to propagate from neuron to neuron in a trans-synaptic manner. Although the precise molecular mechanisms are unclear, the propagation of aSyn is believed to play a major role in the progression of Lewy pathology in PD. Neuropathologically, the initial Lewy pathology has been shown to be formed in the dorsal motor nucleus of the vagus (DMV) or olfactory bulb by neuropathological studies. Since the DMV innervates the enteric nervous system (ENS) and LBs are formed in the gut nerve plexuses, it is conceivable that LBs propagate from the gut to the DMV and then to other regions of the brain. In this article, clinical, neuropathological, and experimental evidence supporting or negating the idea that aSyn propagation from the ENS to the brain leads to PD is reviewed. Moreover, the propagation of aSyn seeds through systemic circulation or multifocal generation of aSyn seeds is discussed as a potential alternative scenario for aSyn spreading.

    DOI： 10.3390/ijms26093994

    PubMed

MISC

  • フィブリル播種によって作製したシヌクレイノパチーの動物モデル　病理学的な機序、疾患モデルの確立、および治療に関する意義(Fibril-seeded animal models of synucleinopathies: Pathological mechanisms, disease modeling, and therapeutic implications)

    Uemura Norihito

    Neuroscience Research   216   j.neures.2025.04.008 - j.neures.2025.04.008   2025.07（ ISSN:0168-0102 ）

    　More details

    Authorship：Lead author,　Last author,　Corresponding author  

  • 非ヒト霊長類マーモセットのタッチパネル行動課題の開発

    孝橋 睦生, Chen Chih-Yang, 澤村 正典, 平藤 哲也, 上村 紀仁, 伊佐 かおる, 中村 昌史, 中西 悦郎, 伊佐 正, 高橋 良輔, 尾上 浩隆

    日本自律神経学会総会プログラム・抄録集   77回   96 - 96   2024.10

  • 多系統萎縮症マーモセットモデル

    上村 紀仁, 尾上 浩隆, 澤村 正典, Chen Chih-Yang, 友成 悠葵, 山本 茂幸, 大庭 弘行, Lee Virginia, 高橋 良輔

    日本自律神経学会総会プログラム・抄録集   77回   113 - 113   2024.10

  • Lewy小体病において、Amyloid βはα-synucleinの伝播を促進する

    成宮 悠爾, 中西 悦郎, 大平 純一朗, 田口 智之, 澤村 正典, 上村 紀仁, 眞木 崇州, 齊藤 貴志, 山門 穂高, 高橋 良輔

    日本自律神経学会総会プログラム・抄録集   77回   112 - 112   2024.10

  • アミロイドβはαシヌクレインの伝播を促進する

    中西 悦郎, 成宮 悠爾, 大平 純一朗, 田口 智之, 澤村 正典, 上村 紀仁, 齊藤 貴志, 山門 穂高, 高橋 良輔

    パーキンソン病・運動障害疾患コングレスプログラム・抄録集   18回   72 - 72   2024.07

Presentations

▼display all

Grant-in-Aid for Scientific Research

  • Establishment of research basis for multiple system atrophy based on disease-specific alpha-synuclein filaments

    Grant-in-Aid for Scientific Research(B)  2026

  • Establishment of research basis for multiple system atrophy based on disease-specific alpha-synuclein filaments

    Grant-in-Aid for Scientific Research(B)  2025

  • Establishment of research basis for multiple system atrophy based on disease-specific alpha-synuclein filaments

    Grant-in-Aid for Scientific Research(B)  2024

Outline of education staff

  • 病態神経科学、脳神経内科学

Charge of on-campus class subject

  • 医学研究推進コース3

    2026   Practical Training   Undergraduate

  • 機能系実習

    2026   Practical Training   Undergraduate

  • 医学概論

    2026   Intensive lecture   Graduate school

  • 機能系実習

    2025   Practical Training   Undergraduate