Updated on 2025/04/09

写真a

 
HARAGUCHI ASAKO
 
Organization
Graduate School of Veterinary Science Department of Veterinary Science Assistant Professor
School of Veterinary Science Department of Veterinary Science
Title
Assistant Professor
Affiliation
Institute of Veterinary Science
Affiliation campus
Rinku Campus

Position

  • Graduate School of Veterinary Science Department of Veterinary Science 

    Assistant Professor  2025.04 - Now

  • School of Veterinary Science Department of Veterinary Science 

    Assistant Professor  2025.04 - Now

Degree

  • 博士（獣医学） （ Kitasato University ） (   Kitasato University )

Papers

  • Anticoccidial activity of the secondary metabolites in alpine plants frequently ingested by wild Japanese rock ptarmigans

    Haraguchi A.

    International Journal for Parasitology: Parasites and Wildlife   25   100967   2024.12（ ISSN:22132244 ）

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  • Cryptosporidium parvum inactivation from short durations of treatment with ozonated water produced by an electrolytic generation system

    Matsubayashi M.

    Parasitology Research   123 ( 11 )   371   2024.11（ ISSN:09320113 ）

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  • Bovine lactoferrin inhibits Plasmodium berghei growth by binding to heme.

    Obayashi M, Kimura M, Haraguchi A, Gotanda M, Kitagawa T, Matsuno M, Sakao K, Hamanaka D, Kusakisako K, Kameda T, Ibrahim HR, Ikadai H, Miyata T

    Scientific reports   14 ( 1 )   20344   2024.09

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  • Molecular phylogenetical identification of bear roundworms (<i>Baylisascaris transfuga</i>) derived from wild Japanese black bears (<i>Ursus thibetanus japonicus</i>) around Lake Towada

    KUSAKISAKO Kodai, KANEDA Nanami, KAMIHARAKO Yuichi, HARAGUCHI Asako, HAKOZAKI Jun, NAKAYAMA Kazuhiko, HASAN Hajar, NAKAMURA Sakure, SHINDO Junji, IKADAI Hiromi

    Journal of Veterinary Medical Science   86 ( 9 )   951 - 955   2024.09（ ISSN:0916-7250 ） （ eISSN:13477439 ）

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    <p>The bear roundworm <i>Baylisascaris transfuga</i> has been identified in several host bears (Ursinae). However, limited genetic information is available on the bear roundworm in Japanese populations. This study evaluated the genetic composition of bear roundworms isolated from wild Japanese black bears indigenous to Lake Towada, Japan. First, we conducted genetic and/or molecular phylogenetic analyses based on cytochrome <i>c</i> oxidase subunit II and internal transcribed spacer 2 among <i>Baylisascaris</i> species. These analyses revealed that the identified roundworms were genetically <i>B. transfuga</i>. In addition, the average body size of the obtained roundworms in this study was almost the same as that previously reported for <i>B. transfuga</i>. This study represents an important step in genetic research on the roundworm <i>B. transfuga</i> in Ursinae bears not only from Japan but also from the rest of the world.</p>

    DOI： 10.1292/jvms.24-0142

    PubMed

  • The C-terminal region of the Plasmodium berghei gamete surface 184-kDa protein Pb184 contributes to fertilization and male gamete binding to the residual body.

    Nakayama K, Haraguchi A, Hakozaki J, Nakamura S, Kusakisako K, Ikadai H

    Parasites & vectors   17 ( 1 )   304   2024.07

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  • Searching for new molecules involved in <i>Anopheles</i> mosquitoes’ response to <i>Plasmodium</i> infection

    HARAGUCHI Asako, TAKANO Makoto, FUJIWARA Kanta, HAKOZAKI Jun, NAKAYAMA Kazuhiko, NAKAMURA Sakure, YOSHIKAWA Yasunaga, FUKUMOTO Shinya, KUSAKISAKO Kodai, IKADAI Hiromi

    Journal of Veterinary Medical Science   86 ( 5 )   485 - 492   2024.05（ ISSN:0916-7250 ） （ eISSN:13477439 ）

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    <p><i>Plasmodium</i> parasites within mosquitoes are exposed to various physiological processes, such as blood meal digestion activity, the gonotrophic cycle, and host responses preventing the entry of parasites into the midgut wall. However, when <i>in vitro</i>-cultured ookinetes are injected into the hemocoel of mosquitoes, <i>Plasmodium</i> parasites are not affected by the vertebrate host’s blood contents and do not pass through the midgut epithelial cells. This infection method might aid in identifying mosquito-derived factors affecting <i>Plasmodium</i> development within mosquitoes. This study investigated novel mosquito-derived molecules related to parasite development in <i>Anopheles</i> mosquitoes. We injected <i>in vitro-</i>cultured <i>Plasmodium berghei</i> (ANKA strain) ookinetes into female and male <i>Anopheles stephensi</i> (STE2 strain) mosquitoes and found that the oocyst number was significantly higher in males than in females, suggesting that male mosquitoes better support the development of parasites. Next, RNA-seq analysis was performed on the injected female and male mosquitoes to identify genes exhibiting changes in expression. Five genes with different expression patterns between sexes and greatest expression changes were identified as being potentially associated with <i>Plasmodium</i> infection. Two of the five genes also showed expression changes with infection by blood-feeding, indicating that these genes could affect the development of <i>Plasmodium</i> parasites in mosquitoes.</p>

    DOI： 10.1292/jvms.24-0008

    PubMed

  • Formation of free oocysts in Anopheles mosquitoes injected with Plasmodium ookinetes Reviewed

    Haraguchi A, Takano M, Hakozaki J, Nakayama K, Nakamura S, Yoshikawa Y, Fukumoto S, Kusakisako K, Ikadai H

    The Journal of Veterinary Medical Science   85 ( 9 )   921 - 928   2023.09

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    Authorship：Lead author   Publishing type：Research paper (scientific journal)  

    DOI： 10.1292/jvms.23-0099.

  • Methylobacterium sp. isolated from the midgut of Anopheles stephensi inhibits egg maturation in host ovary. Reviewed

    Hakozaki J, Nonogaki Y, Tanabe T, Nishiyama K, Nakayama K, Haraguchi A, Nakamura S, Kusakisako K, Ikadai H.

    Applied Entomology and Zoology   58   369 - 377   2023.08

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  • Morphological and molecular phylogenetical identification of Tricodectes pinguis from Japanese black bears (Ursus thibetanus japonicus) in Aomori Reviewed

    Kusakisako K, Niiyama H, Asano E, Haraguchi A, Hakozaki J, Nakayama K, Nakamura S, Shindo J, Kudo N, Ikadai H.

    The Journal of Veterinary Medical Science   84 ( 7 )   1015 - 1018   2022.07

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  • Plasmodium berghei Brca2 is required for normal development and differentiation in mice and mosquitoes. Reviewed

    Yoshikawa Y, Kimura S, Soga A, Sugiyama M, Ueno A, Kondo H, Zhu Z, Ochiai K, Nakayama K, Hakozaki J, Kusakisako K, Haraguchi A, Kitano T, Orino K

    Parasites & Vectors.   15 ( 1 )   244   2022.07

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  • Identification and phylogenetic analysis of Babesia parasites in domestic dogs in Nigeria. Reviewed

    Hirata H, Omobowale T, Adebayo O, Asanuma N, Haraguchi A, Murakami Y, Kusakisako K, Ikeda K, Asakawa M, Suzuki K, Ishihara C, Ikadai H.

    The Journal of Veterinary Medical Science   84 ( 3 )   338 - 341   2022.03

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  • Role of Plasmodium berghei ookinete surface and oocyst capsule protein a novel oocyst capsule-associated protein in ookinete motility. Reviewed

    Nakayama K, Kimura Y, Kitahara Y, Soga A, Haraguchi A, Hakozaki J, Sugiyama M, Kusakisako K, Fukumoto S, Ikadai H.

    Parasites & Vectors.   141 ( 1 )   373   2021.07

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  • Raccoon dogs (Nyctereutes procyonoides) are the new natural definitive hosts of Metagonimus hakubaensis. Reviewed

    Hakozaki J, Kuzukami S, Haraguchi A, Nakayama K, Kusakisako K, Kudo N, Ikadai H.

    The Journal of Veterinary Medical Science   83 ( 6 )   927 - 930   2021.06

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  • Outcome prediction from the first examination in clinical mastitis using ultrasonography in dairy cows. Reviewed

    Suzuki N, Kurose T, Kaneko S, Haraguchi A, Isobe N.

    91 ( 1 )   e13452   2020.01

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  • Serological Survey of Encephalitozoon cuniculi Infection in Japanese Dogs. Reviewed

    Sasaki M, Yamazaki A, Haraguchi A, Tatsumi M, Ishida K, Ikadai H.

    The Journal of Parasitology.   97 ( 1 )   167 - 169   2011.02

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Presentations