Updated on 2026/04/13

写真a

 
KOMAKI YUKAKO
 
Organization
Graduate School of Engineering Division of Urban Engineering Lecturer
School of Engineering Department of Urban Design and Engineering
Title
Lecturer
Affiliation
Institute of Engineering

Position

  • Graduate School of Engineering Division of Urban Engineering 

    Lecturer  2025.04 - Now

  • School of Engineering Department of Urban Design and Engineering 

    Lecturer  2025.04 - Now

Degree

  • Ph.D. in Environmental Engineering ( Others ) (   University of Illinois at Urbana-Champaign )

Research Areas

  • Life Science / Cell biology

  • Environmental Science/Agriculture Science / Environmental impact assessment

  • Social Infrastructure (Civil Engineering, Architecture, Disaster Prevention) / Environmental systems for civil engineering

Research Interests

  • Disinfection byproducts

  • Drinking water

  • Cell culture

  • Toxicity mechanisms

  • DNA damage

  • Epigenetics

Professional Memberships

  • 日本環境変異原ゲノム学会

    2018.01 - Now   Domestic

  • 日本水環境学会

    2017.09 - Now   Domestic

  • 日本分子生物学会

    2021.10 - Now   Domestic

  • 廃棄物資源循環学会

    2025.08 - Now   Domestic

  • 日本生化学会

    2025.04 - Now   Domestic

Job Career (off-campus)

  • Osaka Metropolitan University   Graduate School of Engineering, Department of Urban Design and Engineering

    2025.04 - Now

  • University of Shizuoka   School of Food and Nutritional Sciences

    2017.07 - 2025.03

  • Stanford University   Department of Civil and Environmental Engineering   JSPS Overseas Research Fellow

    2016.06 - 2017.06

  • University of Illinois at Urbana-Chamapaign   Department of Civil and Environmental Engineering   Postdoctoral Research Associate

    2013.12 - 2016.06

Education

  • University of Illinois at Urbana-Champaign   Department of Civil and Environmental Engineering   Doctor's Course   Graduated/Completed

    2007.08 - 2013.12

  • Kyoto University   Master's Course   Graduated/Completed

    2005.04 - 2007.03

  • Kyoto University   Bachelor's Course   Graduated/Completed

    2001.04 - 2005.03

Papers

  • DNA repair–associated nucleases induce double-strand breaks following sequential exposure to UVA1 and UVB Reviewed

    Narimichi, M., Komaki, Y., Suzuki, T. and Ibuki, Y.

    Photochemical & Photobiological Sciences   2026.03( ISSN:1474905X

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    Publishing type:Research paper (scientific journal)   International / domestic magazine:International journal  

    DOI: 10.1007/s43630-026-00874-4

    PubMed

  • Cigarette sidestream smoke-induced cellular senescence and the protective role of histone H2AX. Reviewed

    Komaki, Y., Ibuki, Y.

    Toxicology in Vitro   107   106076 - 106076   2025.08( ISSN:08872333

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    Authorship:Lead author   Publishing type:Research paper (scientific journal)   International / domestic magazine:International journal  

    Cigarette smoke imposes serious health hazards such as cancer and cardiovascular diseases but is also associated with cellular senescence. Recently, histone loss and modifications are reported as one of the characteristics of cellular senescence. In this study, we examined the relationship between cigarette smoke-induced cellular senescence and histone H2A variant H2AX, an important player in DNA damage response. We exposed normal human skin diploid fibroblast ASF-4-1 to cigarette sidestream smoke (CSS) extract and successfully induced premature senescence. Persistent DNA damages are known to induce cellular senescence. Double strand breaks (DSBs) formation was detected in CSS-treated cells, indicating DSBs could be the cause for the CSS-induced cellular senescence. In the senescent cells, persistent phosphorylation of histone H2AX (γ-H2AX) and unexpected increase of H2AX protein expression was observed. To elucidate the role of H2AX in CSS-induced cellular senescence, we depleted H2AX in ASF-4-1 cells with siRNA. In H2AX-depleted cells, CSS-induced elevated β-galactosidase activity was more prominent. CSS concentration-dependent increase of reactive oxygen species and DSBs formation was also facilitated by H2AX depletion. These results suggest that histone H2AX may have a protective role against DNA damage-induced premature senescence.

    DOI: 10.1016/j.tiv.2025.106076

    PubMed

  • Increased matrix metalloproteinase-1 expression by coexposure to UVA and cigarette sidestream smoke and contribution of histone acetylation. Reviewed

    Ito, R., Komaki, Y., Ibuki, Y.

    Genes and Environment   47 ( 1 )   2 - 2   2025.01( ISSN:18807046

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    Publishing type:Research paper (scientific journal)   International / domestic magazine:International journal  

    BACKGROUND: Skin is exposed to various environmental factors throughout life, and some of these factors are known to contribute to skin aging. Long-term solar UV exposure is a well-known cause of skin aging, as is cigarette smoke, which contains a number of chemicals. In this study, combined effect of UVA and cigarette sidestream smoke (CSS) on matrix metalloproteinase-1 (MMP-1) induction was investigated. MMP-1 is the main protease that initiates collagen type I fiber fragmentation in human skin and is associated with aging. RESULTS: Combined exposure to UVA and CSS enhanced MMP-1 induction, accompanied by collagen type I (COL1A1) gene suppression. The basal expression of MMP-1 was higher in senescent cells than in normal cells, with a pronounced increase after coexposure to UVA and CSS. UVA irradiation resulted in global histone H3 acetylation, and we considered this was responsible for the MMP-1 upregulation. Histone deacetylase inhibitors, sodium acetate, propionate, and butyrate, all enhanced the CSS-induced MMP-1 according to the degree of histone acetylation. CONCLUSION: These results suggest that UVA and CSS additively induce MMP-1, which may lead to skin aging, and that such combined effect may further promote aging in aged skin. UVA-induced histone acetylation may contribute to MMP-1 induction.

    DOI: 10.1186/s41021-025-00325-z

    PubMed

  • Faulty Gap Filling in Nucleotide Excision Repair Leads to Double-Strand Break Formation in Senescent Cells. Reviewed

    Suzuki, T., Komaki, Y., Amano, M., Ando, S., Shobu, K., Ibuki, Y.

    Journal of Investigative Dermatology   145 ( 1 )   32 - 41   2025.01( ISSN:0022202X

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    Publishing type:Research paper (scientific journal)   International / domestic magazine:International journal  

    The change of repair efficiency of UV-induced pyrimidine dimers due to aging was examined in replicatively senesced fibroblasts. The fibroblasts with repeated passages showed the characteristics of cellular senescence, including irreversible cell cycle arrest, elevated β-galactosidase activity, and senescence-associated secretory phenotype. The incision efficiency of oligonucleotide containing UV lesions was similar regardless of cell doubling levels, but the gap filling process was impaired in replicatively senescent cells. The releases of xeroderma pigmentosum group G, proliferating cell nuclear antigen, and replication protein A from damaged sites were delayed, which might have disturbed the DNA polymerase progression. The persistent single-stranded DNA was likely converted to double-strand breaks, leading to ataxia telangiectasia-mutated phosphorylation and 53BP1 foci formation. Phosphorylated histone H2AX (γ-H2AX) induction mainly occurred in G1 phase in senescent cells, not in S phase such as in normal cells, indicating that replication stress-independent double-strand breaks might be formed. MRE11 having nuclease activity accumulated to damaged sites at early time point after UV irradiation but not released in senescent cells. The pharmacological studies using specific inhibitors for the nuclease activity suggested that MRE11 contributed to the enlargement of single-stranded DNA gap, facilitating the double-strand break formation.

    DOI: 10.1016/j.jid.2024.04.033

    PubMed

  • Glucose starvation impairs NER and γ-H2AX after UVB irradiation Reviewed

    Choe, J. K., Hua, L.-C., Komaki, Y., Simpson, A. M. A., McCurry, D. L., Mitch, W. A.

    Environmental Science & Technology   86   105503   2023

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    Publishing type:Research paper (scientific journal)  

  • Butyrate Enhances γ-H2AX Induced by Benzo[a]pyrene Reviewed

    Hsiao, A., Komaki, Y., Imaad, S. M., Mariñas, B. J., Plewa, M. J., Liu, G. L.

    Lab Chip   35 ( 12 )   2241 - 2251   2022

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    Publishing type:Research paper (scientific journal)  

  • Protective role of electrophile-reactive glutathione for DNA damage repair inhibitory effect of dibromoacetonitrile Reviewed

    Ibuki, Y., Komaki, Y., Yang, G., Toyooka, T.

    Photochemical & Photobiological Sciences   117   305 - 314   2022

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    Publishing type:Research paper (scientific journal)  

  • Inhibition of nucleotide excision repair and damage response signaling by dibromoacetonitrile: A novel genotoxicity mechanism of a water disinfection byproduct Reviewed

    Fukuda, T., Komaki, Y., Mori, Y., Ibuki, Y.

    Mutation Research/Genetic Toxicology and Environmental Mutagenesis   423   127194   2022

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    Publishing type:Research paper (scientific journal)  

  • 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone-Induced Histone Acetylation via α7nAChR-Mediated PI3K/Akt Activation and Its Impact on γ-H2AX Generation Reviewed

    Kimura, S. Y., Vu, T. N., Komaki, Y., Plewa, M. J., Mariñas, B. J.

    Environmental Science & Technology   34 ( 12 )   2512 - 2521   2021

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    Publishing type:Research paper (scientific journal)  

  • Long-wavelength UVA enhances UVB-induced cell death in cultured keratinocytes: DSB formation and suppressed survival pathway Reviewed

    Komaki, Y., Ibuki, Y.,

    Journal of Hazardous Materials   20 ( 5 )   639 - 652   2021

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    Publishing type:Research paper (scientific journal)  

  • Evaluation of Histidine Reactivity and Byproduct Formation during Peptide Chlorination Reviewed International coauthorship

    Kimura, S. Y., Komaki, Y., Plewa, M. J., Mariñas, B. J.

    Environmental Science & Technology   55 ( 3 )   1790 - 1799   2021

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  • Low extracellular pH inhibits nucleotide excision repair Reviewed

    Komaki, Y., Mariñas, B. J., Plewa, M. J.

    Environmental Science & Technology   867   503374   2021

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    Publishing type:Research paper (scientific journal)  

  • Cell line-dependent difference in glutathione levels affects the cigarette sidestream smoke-induced inhibition of nucleotide excision repair Reviewed

    Komaki, Y., Ono, S., Okuya, T., Ibuki, Y.

    Toxicology in Vitro   858-860   503273   2020

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    Publishing type:Research paper (scientific journal)  

  • Serum electrolytes can promote hydroxyl radical-initiated biomolecular damage from inflammation Reviewed International coauthorship

    Komaki, Y., Plewa, M. J.

    Journal of Environmental Sciences   141   475 - 482   2019

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    Publishing type:Research paper (scientific journal)  

  • Formaldehyde inhibits UV-induced phosphorylation of histone H2AX Reviewed

    Komaki, Y. and Pals, J. and Wagner, E. D. and Mariñas, B. J. and Plewa, M. J.

    Environmental Science & Technology   61   104687   2019

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    Publishing type:Research paper (scientific journal)  

  • Chlorotyrosines versus Volatile Byproducts from Chlorine Disinfection during Washing of Spinach and Lettuce Reviewed International coauthorship

    Komaki, Y., Simpson, A. M.-A. Choe, J. K., Plewa, M. J., Mitch, W. A.

    Environmental Science & Technology   52 ( 16 )   9361 - 9369   2018

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  • Aldehyde-mediated protein degradation is responsible for the inhibition of nucleotide excision repair by cigarette sidestream smoke Reviewed

    Komaki, Y. and Simpson, A. M. and Choe, J. K. and Pinney, M. M. and Herschlag, D. and Chuang, Y. H. and Mitch, W. A.

    Free Radical Biology & Medicine   834   42 - 50   2018

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  • Investigation of nuclear enzyme topoisomerase as a putative molecular target of monohaloacetonitrile disinfection by-products Reviewed International coauthorship

    Komaki, Y., Suganuma, K., Ibuki, Y.

    Journal of Environmental Sciences   58   231 - 238   2017

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    Publishing type:Research paper (scientific journal)  

  • Acetonitrile and N-Chloroacetamide Formation from the Reaction of Acetaldehyde and Monochloramine Reviewed International coauthorship

    Saenz de Jubera, A. M., Herbison, J. H., Komaki, Y., Plewa, M. J., Moore, J. S., Cahill, D. G., Mariñas, B. J.

    Environmental Science & Technology   49 ( 16 )   9954 - 9963   2015

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  • Toxicity of drinking water disinfection byproducts: Cell cycle alterations induced by the monohaloacetonitriles Reviewed International coauthorship

    Tanaka, M., Komaki, Y., Toyooka, T., Ibuki, Y.

    Chemical Research in Toxicology   48 ( 19 )   11662 - 11669   2014

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  • Toxic impact of bromide and iodide on drinking water disinfected with chlorine or chloramines Reviewed International coauthorship

    Shikata, Mariko and Toyooka, Tatsushi and Komaki, Yukako and Ibuki, Yuko

    Chemical Research in Toxicology   48 ( 20 )   12362 - 12369   2014

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    Publishing type:Research paper (scientific journal)  

  • Development and Performance Characterization of a Polyamide Nanofiltration Membrane Modified with Covalently Bonded Aramide Dendrimers Reviewed International coauthorship

    Yang, G. and Komaki, Y. and Ibuki, Y.

    Mutation Research   47 ( 15 )   8642 - 8649   2013

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  • Chloroacetonitrile and N,2-dichloroacetamide formation from the reaction of chloroacetaldehyde and monochloramine in water Reviewed International coauthorship

    Yamashita, R., Komaki, Y., Yang, G., Ibuki, Y.

    Mutation Research/Genetic Toxicology and Environmental Mutagenesis   47 ( 21 )   12382 - 12390   2013

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    Publishing type:Research paper (scientific journal)  

  • Cytotoxicity analysis of water disinfection byproducts with a micro-pillar microfluidic device Reviewed International coauthorship

    Yang, G., Komaki, Y., Yoshida, I., Ibuki, Y.

    Toxicology in Vitro   12   3891 - 3900   2012

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  • Mammalian cell DNA damage and repair kinetics of monohaloacetic acid drinking water disinfection by-products Reviewed International coauthorship

    Yang, Y., Komaki, Y., Kimura, S. Y., Hu, H.-Y., Wagner, E. D., Mariñas, B. J., Plewa, M. J.

    Environmental Science & Technology   43 ( 21 )   8437 - 8442   2009

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    Publishing type:Research paper (scientific journal)  

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Presentations

  • 熱ストレスによる細胞質へのヒストンH2AXの蓄積 Domestic conference

    菖蒲 幸佑, 小牧 裕佳子, 森 優太, 伊吹 裕子

    日本生化学会大会プログラム・講演要旨集  2025.11  (公社)日本生化学会

  • UVA1 とUVB の複合ばく露によるDNA 二 本鎖切断形成と細胞内Nuclease の関与 Domestic conference

    伊吹 裕子, 成道 舞, 鈴木 崇志, 小牧 裕佳子

    日本環境変異原ゲノム学会第54回回大会  2025.11 

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    Presentation type:Poster presentation  

  • ハロアセトニトリル類による細胞周期の攪乱と高倍数体化の誘導 Domestic conference

    小牧 裕佳子, 泉 杏春, 片山 貴穂, 伊吹 裕子

    日本環境変異原ゲノム学会第54回回大会  2025.11 

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  • 熱ストレスによる細胞老化と細胞質へのヒストンH2AXの放出 Domestic conference

    菖蒲 幸佑, 小牧 裕佳子, 森 優太, 伊吹 裕子

    日本環境変異原ゲノム学会第54回回大会  2025.11 

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  • 安全な水道水の供給を目指してー消毒副生成物の毒性機構解明ー Domestic conference

    小牧裕佳子

    第3回研究者交流会  2025.09  大阪公立大学 URAセンター

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    Presentation type:Poster presentation  

    Venue:大阪公立大学 中百舌鳥キャンパス  

  • Hyperploidy induction as novel toxicological endpoints of haloacetonitriles Invited International conference

    Komaki, Y., Izumi, K., Katayama, K., Okamoto, S., Ibuki, Y.

    Gordon Research Conference on Water Disinfection, Byproducts and Health  2025.07 

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    Presentation type:Oral presentation (invited, special)  

  • UVA1とUVBの複合曝露によるDNA二本鎖切断の形成と細胞内ヌクレアーゼの関与 Domestic conference

    伊吹 裕子, 成道 舞, 小牧 裕佳子

    第47回日本光医学・光生物学会  2025.07 

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  • 熱ストレスによる細胞老化と細胞質でのヒストンH2AXのリン酸化 Domestic conference

    菖蒲 幸祐, 森 優太, 小牧 裕佳子,伊吹 裕子

    第89回日本生化学会中部支部例会  2025.05 

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  • UVA1とUVBの複合曝露によるDNA二本鎖切断の形成とMre11の関与 Domestic conference

    成道 舞, 小牧 裕佳子, 伊吹 裕子

    日本環境変異原ゲノム学会第53回大会  2024.12 

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    Presentation type:Oral presentation (general)  

  • ハロアセトニトリル類による細胞周期の攪乱と高倍数体化の誘導 Domestic conference

    泉 杏春, 小牧 裕佳子, 片山 貴穂, 伊吹 裕子

    令和6年度公益社団法人日本水環境学会中部支部研究発表会  2024.12 

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    Presentation type:Poster presentation  

  • ホルムアルデヒドによる早期老化の誘導とヒストンH2AXの役割 Domestic conference

    安藤 智子, 小牧 裕佳子, 鈴木 崇志, 天野 百花, 伊吹 裕子

    日本環境変異原ゲノム学会第53回大会  2024.12 

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  • 老化によるXPG解離遅延は紫外線照射後の二本鎖切断形成の原因となる

    安藤 智子, 小牧 裕佳子, 鈴木 崇志, 天野 百花, 伊吹 裕子

    日本生化学会大会プログラム・講演要旨集  2024.11  (公社)日本生化学会

  • 熱ストレスによる細胞質への核DNA漏出と早期細胞老化誘導への関与

    菖蒲 幸佑, 小牧 裕佳子, 森 優太, 伊吹 裕子

    日本生化学会大会プログラム・講演要旨集  2024.11  (公社)日本生化学会

  • 消毒副生成物ハロアセトニトリル類の細胞周期への影響

    泉 杏春, 小牧 裕佳子, 片山 貴穂, 伊吹 裕子

    日本生化学会大会プログラム・講演要旨集  2024.11  (公社)日本生化学会

  • UVA1とUVBの複合曝露によるDNA二本鎖切断の形成と細胞質遊離DNAの増加 Domestic conference

    成道 舞, 小牧 裕佳子, 伊吹 裕子

    日本生化学会大会プログラム・講演要旨集  2024.11  (公社)日本生化学会

  • 消毒副生成物ハロアセトニトリル類の細胞周期への影響

    小牧 裕佳子, 泉 杏春, 片山 貴穂, 伊吹 裕子

    第61回環境工学研究フォーラム  2024.11 

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  • 赤外線照射によるヌクレオチド除去修復分子の核小体への移行と紫外線DNA損傷修復変化

    三枝 相翔, 菖蒲 幸祐, 小牧 裕佳子, 伊吹 裕子

    第97回日本生化学会大会  2024.11 

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  • UVA1とUVBの複合曝露によるDNA二本鎖切断の形成と細胞質DNA増加の関係

    成道 舞, 小牧 裕佳子, 伊吹 裕子

    第46回日本光医学・光生物学会  2024.07 

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  • 熱ストレスによる細胞質へのDNAの遊離と老化誘導

    菖蒲 幸祐, 小牧 裕佳子, 森 優太, 伊吹 裕子

    第88回日本生化学会中部支部例会  2024.05 

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  • 老化は紫外線照射後のNER分子の挙動を変化させDSBsを形成させる

    安藤 智子, 小牧 裕佳子, 鈴木 崇志, 天野 百花, 伊吹 裕子

    第88回日本生化学会中部支部例会  2024.05 

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  • 長波長紫外線UVA1とUVBの複合曝露によるDNA二本鎖切断の形成とPARP1活性の増強

    成道 舞, 小牧 裕佳子, 伊吹 裕子

    第96回日本生化学会大会  2023.11 

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  • 熱ストレスによるDNA損傷の誘導と細胞老化

    菖蒲 幸祐, 小牧 裕佳子, 森 優太, 伊吹 裕子

    第96回日本生化学会大会  2023.11 

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  • UVA1とUVBの複合曝露によるDNA二本鎖切断の形成―細胞質DNAとの関係―

    成道 舞, 小牧 裕佳子, 伊吹 裕子

    日本環境変異原ゲノム学会第52回大会  2023.11 

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  • タバコ副流煙による細胞老化誘導とヒストンH2AXノックダウンの影響

    小牧 裕佳子, 伊吹 裕子

    日本環境変異原ゲノム学会第52回大会  2023.11 

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  • タバコ副流煙による細胞老化誘導とヒストンH2AXノックダウンの影響

    小牧 裕佳子, 伊吹 裕子

    日本環境変異原ゲノム学会第52回大会  2023.11 

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  • 熱によるヌクレオチド除去修復分子の核小体への移行とその理由

    伊吹 裕子, 小牧 裕佳子

    第45回日本光医学・光生物学会  2023.06 

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    Presentation type:Oral presentation (general)  

  • A novel genotoxicity mechanism of a water disinfection byproduct: Inhibition of nucleotide excision repair and damage response signaling by dibromoacetonitrile Invited

    Komaki, Y., Ibuki, Y

    HKUST Form on Innovative Disinfection and Emerging Disinfection Byproducts  2023.03 

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    Presentation type:Oral presentation (invited, special)  

  • 消毒副生成物ハロアセトニトリル類による細胞周期への影響

    小牧 裕佳子, 片山 貴穂, 伊吹 裕子

    第57回日本水環境学会年会  2023.03 

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  • タバコ煙と紫外線によるMMP-1上昇と老化の関係

    伊東 稜真, 小牧 裕佳子, 伊吹 裕子

    第95回日本生化学会大会  2022.11 

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  • 長波長紫外線UVA1とUVBの複合曝露によるDNA二本鎖切断の生成と細胞質へのDNA放出

    成道 舞, 小牧 裕佳子, 伊吹 裕子

    第95回日本生化学会大会  2022.11 

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  • 老化に伴うヌクレオチド除去修復の遅延とDNA二本鎖切断の形成

    鈴木 崇志, 天野 百花, 小牧 裕佳子, 伊吹 裕子

    第95回日本生化学会大会  2022.11 

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  • 熱ストレスによるDeoxyribonuclease Iの遊離とヒストンH2AXリン酸化

    森 優太, 小牧 裕佳子, 豊岡 達士, 伊吹 裕子

    第95回日本生化学会大会  2022.11 

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  • タバコ副流煙による細胞老化誘導とヒストンH2AX

    小牧 裕佳子, 伊吹 裕子

    日本環境変異原ゲノム学会第51回大会  2022.11 

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  • ホルムアルデヒド作用による早期老化とヌクレオチド除去修復の遅延

    鈴木 崇志, 小牧 裕佳子, 伊吹 裕子

    日本環境変異原ゲノム学会第51回大会  2022.11 

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  • 小胞体からのヌクレアーゼ遊離による新規γ-H2AX誘導メカニズム

    森 優太, 小牧 裕佳子, 豊岡 達士, 伊吹 裕子

    日本環境変異原ゲノム学会第51回大会  2022.11 

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  • 老化に伴うヌクレオチド除去修復の遅延とDNA二本鎖切断の形成

    鈴木 崇志, 天野 百花, 小牧 裕佳子, 伊吹 裕子

    第95回日本生化学会大会  2022.11 

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  • 熱ストレスによるDeoxyribonuclease Iの遊離とヒストンH2AXリン酸化

    森 優太, 小牧 裕佳子, 豊岡 達士, 伊吹 裕子

    第95回日本生化学会大会  2022.11 

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  • 老化に伴う紫外線DNA損傷修復の遅延とそれに伴うDNA二本鎖切断の形成

    鈴木 崇志, 天野 百花, 小牧 裕佳子, 伊吹 裕子

    日本放射線影響学会第65回大会  2022.09 

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  • 熱ストレスによる紫外線DNA損傷修復の遅延とXPCの核小体への移行

    伊吹 裕子, 小牧 裕佳子, 熊谷 花子

    第44回日本光医学・光生物学会  2022.06 

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  • 消毒副生成物ジブロモアセトニトリルの毒性におけるグルタチオンの役割

    小牧 裕佳子, 菅沼 光希,伊吹 裕子

    第56回水環境学会年会  2022.03 

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  • 培地中グルコース濃度によるγ-H2AXの変化

    奥谷 卓音, 小牧 裕佳子, 伊吹 裕子

    日本環境変異原ゲノム学会第50回記念大会  2021.11 

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  • タバコ副流煙による細胞老化の誘導とDNA損傷修復応答の変化

    小牧 裕佳子, 伊吹 裕子

    日本環境変異原ゲノム学会第50回記念大会  2021.11 

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  • 老化に伴う紫外線誘導γ-H2AX の変化―NER分子解離遅延との関係

    鈴木 崇志, 天野 百花, 小牧 裕佳子, 伊吹 裕子

    日本環境変異原ゲノム学会第50回記念大会  2021.11 

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  • 熱ストレスによるヒストンH2AX リン酸化を指標とした組織老化の新規評価法

    森 優太, 鈴木 崇志, 豊岡 達士, 小牧 裕佳子, 伊吹 裕子

    日本環境変異原ゲノム学会第50回記念大会  2021.11 

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  • 皮膚温度の上昇は紫外線 DNA損傷修復とヒストン H2AXリン酸化を阻害する

    熊谷 花子, 森 優太, 小牧 裕佳子, 伊吹 裕子

    第94回日本生化学会大会   2021.11 

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  • 消毒副生成物ジブロモアセトニトリルによる細胞老化の促進とDNA損傷修復への影響

    菅沼 光希, 小牧 裕佳子, 伊吹 裕子

    第94回日本生化学会大会   2021.11 

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  • 細胞骨格アクチン崩壊によるヒストン H2AXリン酸化を指標とした組織の老化評価法の構築

    森 優太, 鈴木 崇志, 豊岡 達士, 小牧 裕佳子, 伊吹 裕子

    第94回日本生化学会大会   2021.11 

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  • 老化による紫外線 DNA損傷修復の遅延と損傷応答分子ヒストンH2AXリン酸化の関係

    鈴木 崇志, 天野 百花, 小牧 裕佳子, 伊吹 裕子

    第94回日本生化学会大会  2021.11 

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  • 長波長紫外線UVA1はDNA二本鎖切断生成や生存シグナルの抑制を介してUVBによる細胞死を亢進する

    伊吹 裕子, 小牧 裕佳子, 楊 光, 豊岡 達士

    日本放射線影響学会第64回大会  2021.09 

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  • 熱ストレスによるアクチン崩壊とヒストンH2AXのリン酸化

    森 優太, 小牧 裕佳子, 福田 哲也, 豊岡 達士, 伊吹 裕子

    日本放射線影響学会第64回大会  2021.09 

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  • ジブロモアセトニトリルによるヌクレオチド除去修復阻害とグルタチオン枯渇の関係

    菅沼 光希, 小牧 裕佳子, 伊吹 裕子

    第55回日本水環境学会年会  2021.03 

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  • たばこ副流煙によるヒストン変化と紫外線DNA損傷修復応答

    奥谷 卓音, 楊 光, 小牧 裕佳子, 伊吹 裕子

    第42回日本光医学・光生物学会  2021.01 

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  • たばこ副流煙による紫外線誘導DNA 損傷修復応答の低下とヒストン量の変化

    奥谷 卓音, 楊 光, 小牧 裕佳子, 伊吹 裕子

    日本環境変異原学会第49回大会  2020.11 

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  • 老化に伴う紫外線誘導γ-H2AX の変化

    鈴木 崇志, 天野 百花, 小牧 裕佳子, 伊吹 裕子

    日本環境変異原学会第49回大会  2020.11 

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  • 熱ストレスによる細胞骨格変化とヒストンH2AX のリン酸化誘導

    森 優太, 福田 哲也, 小牧 裕佳子, 豊岡 達士, 伊吹 裕子

    日本環境変異原学会第49回大会  2020.11 

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  • バイオアッセイの未来~水道消毒副生成物のDNA損傷生成・修復評価の観点から Invited

    小牧 裕佳子, 伊吹 裕子

    第23回日本水環境学会シンポジウム  2020.09 

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    Presentation type:Oral presentation (invited, special)  

  • ジブロモアセトニトリルによるヌクレオチド除去修復阻害

    小牧 裕佳子, 伊吹 裕子

    第54回日本水環境学会年会  2020.03 

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  • Aging altered histone modification and repair response to UV-induced DNA damage

    Amano, M., Komaki, Y., Ibuki, Y.

    第24回静岡健康・長寿学術フォーラム  2019.11 

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  • Repair response to DNA damage altered by glucose concentration

    Okuya, T., Komaki, Y., Ibuki, Y.

    第24回静岡健康・長寿学術フォーラム  2019.11 

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  • Acidic condition delays nucleotide excision repair

    Fukuda, T., Komaki, Y., Ibuki, Y.

    第24回静岡健康・長寿学術フォーラム  2019.11 

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  • Energy metabolism changes histone H2AX phosphorylation after UV irradiation

    伊吹 裕子, 小野 早紀, 奥谷 卓音, 小牧 裕佳子

    放射線影響学会第62回大会   2019.11 

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  • 水道水中の消毒副生成物ハロ酢酸類の毒性評価

    藪田 慎也, 小牧 裕佳子, 伊吹 裕子

    令和元年度日本水環境学会中部支部研究発表会  2019.11 

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  • Acid condition delays nucleotide excision repair

    Ibuki, Y., Fukuda, T., Komaki, Y.

    The 6th Asian Congress on Environmental Mutagens and the 48th Annual Meeting of the Japanese Environmental Mutagen Society  2019.11 

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  • Nucleotide excision repair disruption by dibromoacetonitrile

    Komaki, Y., Ibuki, Y.

    The 6th Asian Congress on Environmental Mutagens and the 48th Annual Meeting of the Japanese Environmental Mutagen Society  2019.11 

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  • Chlorination of bisphenol A changed histone acetylation and DNA damage response

    Shindo, T., Komaki, Y., Ibuki, Y.

    The 6th Asian Congress on Environmental Mutagens and the 48th Annual Meeting of the Japanese Environmental Mutagen Society  2019.11 

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  • Actin disruption causes DNA double strand breaks

    Fukuda, T., Komaki, Y., Ibuki, Y.

    The 6th Asian Congress on Environmental Mutagens and the 48th Annual Meeting of the Japanese Environmental Mutagen Society  2019.11 

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  • Nucleotide excision repair disruption by dibromoacetonitrile

    Komaki, Y., Ibuki, Y.

    The 6th Asian Congress on Environmental Mutagens and the 48th Annual Meeting of the Japanese Environmental Mutagen Society  2019.11 

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  • 老化に伴うヒストン修飾変化と紫外線誘導DNA損傷修復応答

    天野 百花, 小牧 裕佳子, 伊吹 裕子

    第92回日本生化学会大会  2019.09 

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  • 紫外線によるヒストンH2AXのリン酸化に対する培養液中グルコース濃度の影響

    小野 早紀, 小牧 裕佳子, 伊吹 裕子

    第92回日本生化学会大会  2019.09 

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  • 老化に伴うヒストン修飾変化と紫外線誘導DNA損傷修復応答

    天野 百花, 小牧 裕佳子, 伊吹 裕子

    第92回日本生化学会大会  2019.09 

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  • Formaldehyde inhibits UV induced phosphorylation of histone H2AX

    Yang, G., Komaki, Y., Ibuki, Y.

    The 16th International Congress of Radiation Research  2019.08 

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  • Dibromoacetonitrile disrupts nucleotide excision repair

    Komaki, Y., Ibuki, Y.

    Gordon Research Conference on Water Disinfection, Byproducts and Health  2019.07 

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  • 老化に伴うヒストン修飾変化と紫外線誘導DNA損傷応答

    天野 百花, 小牧 裕佳子, 伊吹 裕子

    第41回日本光医学・光生物学会  2019.07 

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  • ヒストン脱アセチル化酵素阻害剤によるベンゾ[a]ピレン誘導γ-H2AXの亢進

    田中 美妃, 小牧 裕佳子, 豊岡 達士, 伊吹裕子

    日本環境変異原学会第47回大会  2018.11 

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  • Cigarette sidestream smoke delays nucleotide excision repair: inhibited accumulation of repair proteins at DNA lesions

    Yang, G. Komaki, Y., Ibuki, Y.

    第23回静岡健康・長寿学術フォーラム  2018.11 

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  • ヒストン脱アセチル化酵素阻害剤によるベンゾ[a]ピレン誘導γ-H2AXの亢進.

    田中 美妃, 小牧 裕佳子, 豊岡 達士, 伊吹 裕子

    日本環境変異原学会第47回大会  2018.11 

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  • 消毒副生成物ハロアセトニトリル類毒性機序解明を目指した分子ターゲット探索の試み

    小牧 裕佳子, Michael Plewa

    第52回日本水環境学会年会  2018.03 

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  • Chlorotyrosines versus volatile byproducts from disinfection during washing of lettuce and spinach

    Mitch, W., Komaki, Y., Simpson, A.

    The 255th ACS National Meeting  2018.03 

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  • When ROS are not ROS: The effect of salts on the degradation of protein

    Mitch, W., Komaki, Y., Choe, J. K.

    The 255th American Chemical Society (ACS) National Meeting  2018.03 

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  • 長波長紫外線UVA1によるヒストンH3S10のリン酸化

    平井 雅篤, 小牧 裕佳子, 伊吹 裕子

    ConBio2017  2017.12 

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  • uxtaposing volatile DBP formation with the formation of tyrosine derivatives during the chlorination of spinach and lettuce

    Simpson, A., Komaki, Y., Choe, J. K., Mitch, W. A.

    Gordon Research Conference on DBPs  2017.07 

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  • Application of disinfection chemistry to biochemistry: Reactive halogen species as a potential culprit of oxidative stress in biological systems

    Komaki, Y., Choe, J. K., Mitch, W. A.

    Gordon Research Conference on DBPs  2017.07 

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  • Formation of vegetable-derived disinfection byproducts

    2017.04 

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  • Impact of halides on the degradation of amino acid residues in biomolecules

    2017.04 

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  • Inhibition of topoisomerase enzyme by haloacetonitrile disinfection byproducts

    Komaki, Y., Mariñas, B. J., Plewa, M. J.

    Gordon Research Conference on DBPs  2015.08 

  • Biological mechanism of the toxicity of haloacetonitrile disinfection byproducts

    Komaki, Y., Mariñas, B. J., Plewa, M. J.

    Association of Environmental Engineering and Science Professors Research & Education Conference  2015.06 

  • Cell cycle alterations induced by haloacetonitrile disinfection byproducts

    2014.08 

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  • DNA damage induction, DNA repair, and cell cycle alterations by monohalogenated disinfection byproducts: Haloacetic acids and haloacetonitriles

    Komaki, Y., Mariñas, B. J., Plewa, M. J.

    The 248th ACS National Meeting  2014.08 

  • Comparative toxicity of free and combined chlorination with different levels of halide ions

    2014.08 

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  • Cell cycle blockage effect induced by haloacetonitriles in Chinese hamster ovary cells

    Komaki, Y., Mariñas, B. J., Plewa, M. J.

    Association of Environmental Engineering and Science Professors Research & Education Conference  2013.07 

  • Toxicity of haloacetonitrile DBPs

    Komaki, Y., Mariñas, B. J., Plewa, M. J.

    Gordon Research Conference on DBPs  2012.08 

  • Measurement of genotoxicity induction and subsequent repair efficiency rate of monohaloacetonitriles using mammalian cells

    2011.10 

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  • Elucidating DNA repair kinetics of haloacetonitriles in Chinese hamster ovary cells and effect on cell cycle arrest

    Komaki, Y., Mariñas, B. J., Plewa, M. J.

    The 42nd Environmental Mutagen Society Annual Meeting  2011.10 

  • Comparative DNA damage and repair kinetics study of monohaloacetonitriles in mammalian cells

    Komaki, Y., Pals, J., Wagner, E. D., Mariñas, B. J., Plewa, M. J.

    The 41st Environmental Mutagen Society Annual Meeting  2010.10 

  • DNA repair kinetics study of monohaloacetonitriles in mammalian cells

    Komaki, Y., Kimura, S., Pals, J., Wagner, E. D., Plewa, M. J., Mariñas, B. J.

    The 239th ACS National Meeting  2010.03 

  • Comparative DNA damage and repair kinetics study in mammalian cells by chloro-, bromo-, and iodoacetic acid

    Komaki, Y., Pals, J., Wagner, E. D., Mariñas, B. J., Plewa, M. J.

    The 40th Environmental Mutagen Society Annual Meeting  2009.10 

  • Comparative DNA damage and repair kinetics study in mammalian cells by chloro-, bromo-, and iodoacetic acid.

    Komaki, Y., Pals, J., Wagner, E. D., Mariñas, B. J., Plewa, M. J.

    Gordon Research Conference on DBPs  2009.08 

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Grant-in-Aid for Scientific Research

  • 地球温暖化による皮膚がんの増加予測を細胞外DNAで検証する

    Grant-in-Aid for Scientific Research(C)  2028

  • 消毒副生成物ハロアセトニトリル類特異的な高倍数体化誘導における機序解明

    Grant-in-Aid for Scientific Research(C)  2028

  • 消毒副生成物ハロアセトニトリル類特異的な高倍数体化誘導における機序解明

    Grant-in-Aid for Scientific Research(C)  2027

  • 地球温暖化による皮膚がんの増加予測を細胞外DNAで検証する

    Grant-in-Aid for Scientific Research(C)  2027

  • 消毒副生成物ハロアセトニトリル類特異的な高倍数体化誘導における機序解明

    Grant-in-Aid for Scientific Research(C)  2026

  • 地球温暖化による皮膚がんの増加予測を細胞外DNAで検証する

    Grant-in-Aid for Scientific Research(C)  2026

  • 消毒副生成物による細胞周期異常誘発の機序解明と高感度長期毒性評価法としての提案

    Grant-in-Aid for Scientific Research(C)  2025

  • Global warming and increase of skin cancer: relationship between heat-induced liquid-liquid phase separation and repair inhibition of UV-generated DNA damage

    Grant-in-Aid for Scientific Research(C)  2025

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Charge of on-campus class subject

  • 都市工学のための科学基礎

    2025   Weekly class   Undergraduate

  • スマートシティ創生演習

    2025   Weekly class   Undergraduate

  • 都市学卒業研究B

    2025   Intensive lecture   Undergraduate

  • 環境計測学

    2025   Weekly class   Undergraduate

  • 都市系特別研究第2

    2025   Intensive lecture   Graduate school

  • 都市系特別研究第1

    2025   Intensive lecture   Graduate school

  • 都市学入門

    2025   Weekly class   Undergraduate

  • 都市学実験

    2025   Weekly class   Undergraduate

  • 都市学卒業研究A

    2025   Intensive lecture   Undergraduate

  • 都市環境学

    2025   Weekly class   Undergraduate

  • 学外実習

    2025   Intensive lecture   Undergraduate

  • 水処理工学

    2025   Weekly class   Undergraduate

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Charge of off-campus class subject

  • 環境計量論

    Institution:University of Shizuoka

  • 環境科学英語II

    Institution:University of Shizuoka

  • 環境生命科学実験

    Institution:University of Shizuoka

  • 光環境生命科学特論

    Institution:University of Shizuoka

Number of instructed thesis, researches

  • 2025

    Number of instructed the graduation thesis: