Researcher Profiles - TAMAI KOJI

写真a

TAMAI KOJI

Organization

Graduate School of Medicine Department of Clinical Medical Science Lecturer
School of Medicine Department of Medical Science

Affiliation

Institute of Medcine

Affiliation campus

Abeno Campus

Position

Graduate School of Medicine Department of Clinical Medical Science

Lecturer 2025.04 - Now
School of Medicine Department of Medical Science

Lecturer 2025.04 - Now

Degree

博士（医学）（ Osaka City University ）

Research Areas

Life Science / Orthopedics / Orthopaedic Surgery
Life Science / Orthopedics / Spine surgery
Life Science / Orthopedics / Fraility
Life Science / Orthopedics / Artificial intelligence

Research Interests

Orthopaedic Surgery, Musculoskeletal System, Spine Surgery, Spine, Geriatrics, Frailty, Artificial Intelligence

Professional Memberships

日本脊椎脊髄病学会

2012.04 - Now
日本整形外科学会

2010.04 - Now
日本インストゥルメンテーション学会

2018.04 - Now
中部日本整形災害外科学会

2010.04 - Now
North America Spine Society

2016.04 - Now
SPINE20

2019.01 - Now
Cervical Spine Research Society

2018.04 - Now

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Committee Memberships (off-campus)

International Strategic Growth Committee member

2024.09 - Now
日本脊椎脊髄病学会社会保険等システム検討委員会委員

2024.04 - Now
日本脊椎脊髄病学会評議員

2024.04 - Now
日本脊椎脊髄病学会英文誌編集委員会委員

2024.04 - Now
日本脊椎脊髄病学会国際委員会委員

2023.10 - Now
SPINE20 Chair of Scientific Committee

2023.09 - Now

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Awards

日本整形外科学会奨励賞

2026 日本整形外科学会
JOS Associated Editor Recommended Reviewers

2025
仁澪奨励賞

2024 仁澪会
Teacher of the year 2024

2024 大阪公立大学医学部医学科
最優秀Discusser賞

2023.08 Japan Association of Spine Surgeons with Ambition
最優秀演題賞

2021 AO spine Japan congress/conference
20 under 40 award

2021
若手研究者奨励賞

2020 大阪市立大学
台湾脊椎外科学会トラベリングフェロー

2020 日本脊椎脊髄病学会
香港骨化学会トラベリングフェロー

2020 日本整形外科学会
アジアトラベリングフェロー

2019 日本脊椎脊髄病学会
同門会賞

2018 大阪市立大学整形外科同門会
アルファテック・パシフィック奨励賞

2015 整形災害外科学研究助成財団

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Job Career (off-campus)

大阪市立総合医療センター

2012.04 - 2013.03
清恵会病院

2008.04 - 2012.03

Papers

Does pretreatment Pfirrmann grade modify response to intradiscal condoliase injection for lumbar disc herniation?

Watanabe K, Takahashi Y, Michikawa T, Takahashi T, Banno T, Sakaki K, Arai Y, Takano Y, Eguchi Y, Taniguchi Y, Maki S, Aoki Y, Fujii S, Sakaeda K, Matsukura Y, Akazawa T, Minamide A, Nojiri H, Sakai K, Kato S, Tamai K, Suzuki H, Miyagi M, Yoshii T, Yamada H, Kaito T, Hiraizumi Y, Yamagata M, Nakamura M, Hosogane N, Ohtori S, Hirai T

Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association 2026.07（ ISSN:0949-2658 ）

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DOI： 10.1016/j.jos.2026.06.012

PubMed
Response to the Letter to the Editor Regarding: "Predicting Postoperative Neurological Outcomes in Metastatic Spinal Tumor Surgery Using Machine Learning".

Maki S, Shiratani Y, Orita S, Suzuki A, Tamai K, Shimizu T, Kakutani K, Kanda Y, Tominaga H, Kawamura I, Ishihara M, Paku M, Takahashi Y, Funayama T, Miura K, Shirasawa E, Inoue H, Kimura A, Iimura T, Moridaira H, Nakajima H, Watanabe S, Akeda K, Takegami N, Nakanishi K, Sawada H, Matsumoto K, Funaba M, Suzuki H, Funao H, Oshigiri T, Hirai T, Otsuki B, Kobayakawa K, Uotani K, Manabe H, Tanishima S, Hashimoto K, Iwai C, Yamabe D, Hiyama A, Seki S, Kato K, Miyazaki M, Watanabe K, Nakamae T, Kaito T, Nakashima H, Nagoshi N, Inoue G, Imagama S, Watanabe K, Kato S, Ohtori S, Furuya T

Spine 2026.07（ ISSN:0362-2436 ）

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DOI： 10.1097/BRS.0000000000005790

PubMed
Extent of intramedullary short tau inversion recovery signal change predicts traumatic cervical spinal cord injury outcomes in surgically treated older adults: a multicenter study in Japan.

Takizawa T, Ikegami S, Uehara M, Oba H, Yokogawa N, Sasagawa T, Nakashima H, Segi N, Ito S, Funayama T, Eto F, Yamaji A, Watanabe K, Nori S, Takeda K, Furuya T, Yunde A, Nakajima H, Yamada T, Hasegawa T, Terashima Y, Hirota R, Suzuki H, Imajo Y, Tonomura H, Sakata M, Hashimoto K, Onoda Y, Kawaguchi K, Haruta Y, Suzuki N, Kato K, Uei H, Sawada H, Nakanishi K, Terai H, Tamai K, Kuroda A, Inoue G, Yurube T, Kakiuchi Y, Kiyasu K, Tominaga H, Iizuka Y, Takasawa E, Akeda K, Takegami N, Funao H, Oshima Y, Kaito T, Sakai D, Yoshii T, Ohba T, Otsuki B, Seki S, Miyazaki M, Ishihara M, Okada S, Imagama S, Kato S

Asian spine journal 2026.07（ ISSN:1976-1902 ）

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DOI： 10.31616/asj.2025.0748

PubMed
Tree-based and sparse logistic models for predicting one-month postoperative performance status after surgery for spinal metastases.

Maki S, Shiratani Y, Orita S, Suzuki A, Tamai K, Shimizu T, Kakutani K, Kanda Y, Tominaga H, Kawamura I, Ishihara M, Paku M, Takahashi Y, Funayama T, Miura K, Shirasawa E, Inoue H, Kimura A, Iimura T, Moridaira H, Nakajima H, Watanabe S, Akeda K, Takegami N, Nakanishi K, Sawada H, Matsumoto K, Funaba M, Suzuki H, Funao H, Oshigiri T, Hirai T, Otsuki B, Kobayakawa K, Uotani K, Manabe H, Tanishima S, Hashimoto K, Iwai C, Yamabe D, Hiyama A, Seki S, Kato K, Miyazaki M, Watanabe K, Nakamae T, Kaito T, Nakashima H, Nagoshi N, Inoue G, Imagama S, Watanabe K, Kato S, Ohtori S, Furuya T

European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society 2026.05（ ISSN:0940-6719 ）

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DOI： 10.1007/s00586-026-09957-3

PubMed
A regression-based equation for postoperative spontaneous correction of the unfused proximal thoracic curve in lenke types 1 and 2 adolescent idiopathic scoliosis.

Iwamae M, Takahashi S, Kinoshita Y, Kato M, Toyoda H, Suzuki A, Tamai K, Sawada Y, Okamura Y, Kobayashi Y, Uematsu M, Taniwaki H, Tsujino M, Nakamura H, Terai H

European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society 2026.05（ ISSN:0940-6719 ）

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DOI： 10.1007/s00586-026-10018-y

PubMed
Phase II study of maintenance trifluridine/tipiracil (TAS-102) plus bevacizumab after induction chemotherapy in metastatic colorectal cancer

Ota K.

Oncologist 31 ( 5 ) 2026.05（ ISSN:10837159 ）

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DOI： 10.1093/oncolo/oyag067
特集骨粗鬆症性脊柱障害の治療戦略-保存から手術,そしてその先へ第4章　種々の病態に対する手術の工夫 -骨粗鬆症性椎体骨折(後壁骨折)に対する前方支柱の再建-脊椎後弯に対するimpaction bone grafting(IBG)法を用いた脊柱再建術

上松正人, 小林祐人, 馬野雅之, 岩前真由, 玉井孝司, 寺井秀富

脊椎脊髄ジャーナル 39 ( 4 ) 419 - 427 2026.04（ ISSN:09144412 ）

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DOI： 10.11477/mf.091444120390040419

CiNii Research
【骨粗鬆症性脊柱障害の治療戦略-保存から手術,そしてその先へ】(第4章)種々の病態に対する手術の工夫　骨粗鬆症性椎体骨折(後壁骨折)に対する前方支柱の再建　脊椎後彎に対するimpaction bone grafting(IBG)法を用いた脊柱再建術

上松正人, 小林祐人, 馬野雅之, 岩前真由, 玉井孝司, 寺井秀富

脊椎脊髄ジャーナル 39 ( 4 ) 419 - 427 2026.04（ ISSN:0914-4412 ）

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＜文献概要＞はじめに　脊椎後彎変形は腰背部痛を引き起こし,日常生活動作(ADL)の低下をもたらすことが知られている.その原因としては,椎体骨折,感染,術後failure,先天性疾患などさまざまな要因がある.近年,人口の高齢化により骨粗鬆症性椎体骨折患者や脊椎感染症患者の発生は増加しており,それに伴って脊椎後彎変形に対する外科的治療の機会も増えている.後彎変形に対する手術では,前方アプローチによる椎体置換術や腸骨移植術,もしくは後方アプローチによるケージを用いたposterior-vertebral column resection(p-VCR)などが行われている.しかし,前方アプローチは開胸操作を伴うため侵襲が大きく,前方・後方アプローチでは前方支柱再建時に用いるインプラントの沈下や形状的制約といった問題が生じる.これらの課題を考慮し,当科では人工骨[β-リン酸三カルシウム(β-tricalcium phosphate:β-TCP)]を大量に用いるimpaction bone grafting(IBG)法を開発し,脊椎後彎変形に対して後方アプローチでケージを使わない前方支柱再建を行ってきた.本稿では,IBG法を用いた前方支柱再建術の適応と手術療法,臨床成績について詳述する.
Impact of delayed diagnosis on surgical management and neurological outcomes in elderly patients with cervical spinal cord injury without radiographic evidence of trauma: a multicenter registry study.

Yamada T, Yamato Y, Hasegawa T, Matsuyama Y, Yokogawa N, Sasagawa T, Nakashima H, Segi N, Ito S, Funayama T, Eto F, Yamaji A, Watanabe K, Nori S, Takeda K, Furuya T, Yunde A, Nakajima H, Terashima Y, Hirota R, Suzuki H, Imajo Y, Ikegami S, Uehara M, Tonomura H, Sakata M, Hashimoto K, Onoda Y, Kawaguchi K, Haruta Y, Suzuki N, Kato K, Uei H, Sawada H, Nakanishi K, Terai H, Tamai K, Kuroda A, Inoue G, Kakutani K, Kakiuchi Y, Kiyasu K, Tominaga H, Iizuka Y, Takasawa E, Akeda K, Takegami N, Funao H, Oshima Y, Kaito T, Sakai D, Yoshii T, Ohba T, Otsuki B, Seki S, Miyazaki M, Ishihara M, Okada S, Imagama S, Kato S

Spinal cord 64 ( 4 ) 324 - 330 2026.04（ ISSN:1362-4393 ）

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DOI： 10.1038/s41393-026-01185-2

PubMed
Lifestyle factors, including physical activity status, associated with fragility fractures and falls: a cross-sectional study.

Iwamae M, Tamai K, Ikebuchi M, Takahashi S, Higuchi Y, Uemura K, Ueda M, Okazaki K, Yokoyama H, Kawabata H, Nakamura H, Terai H

BMC geriatrics 26 ( 1 ) 2026.03

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DOI： 10.1186/s12877-026-07344-7

PubMed
Impact of symptom duration on the effectiveness of intradiscal condoliase injection for lumbar disc herniation: A multicenter retrospective study.

Watanabe K, Takahashi Y, Michikawa T, Takahashi T, Banno T, Sakaki K, Arai Y, Takano Y, Eguchi Y, Taniguchi Y, Maki S, Aoki Y, Fujii S, Sakaeda K, Matsukura Y, Akazawa T, Minamide A, Nojiri H, Sakai K, Kato S, Tamai K, Suzuki H, Miyagi M, Yoshii T, Yamada H, Kaito T, Hiraizumi Y, Yamagata M, Nakamura M, Hosogane N, Ohtori S, Hirai T

Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association 2026.03（ ISSN:0949-2658 ）

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DOI： 10.1016/j.jos.2026.02.009

PubMed
Efficacy of Chemonucleolysis With Condoliase Versus Minimally Invasive Discectomy for Lumbar Disc Herniation: A Propensity Score-Matched Retrospective Cohort Study.

Masato Uematsu, Koji Tamai, Minori Kato, Hiromitsu Toyoda, Akinobu Suzuki, Shinji Takahashi, Yuta Sawada, Masayoshi Iwamae, Yuki Okamura, Yuto Kobayashi, Hiroshi Taniwaki, Yuki Kinoshita, Hiroaki Nakamura, Hidetomi Terai

Global spine journal 16 ( 2 ) 1221 - 1231 2026.03（ ISSN:21925682 ）

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Publishing type：Research paper (scientific journal) International / domestic magazine：International journal

Study DesignRetrospective cohort study.ObjectiveCondoliase is a chemonucleolysis for lumbar disc herniation (LDH) that enzymatically degrades herniated disc material with high specificity for chondroitin sulfate and hyaluronic acid. Few studies have compared condoliase treatment with surgical treatments. We compared the clinical outcomes of condoliase treatment and minimally invasive discectomy.MethodsPatients who received condoliase treatment or minimally invasive discectomy at single institution were included. Propensity score matching was performed to adjust for age and sex. We included 146 patients with LDH (73 per group). The Japan Orthopaedic Association (JOA) score, visual analog scale (VAS) for leg pain, and disc height and degeneration were assessed at baseline and 2 weeks, 3 months, and 1 year after treatment.ResultsThe JOA score and leg pain VAS improved significantly over time (P < .001, Friedman's test). Two weeks after treatment, a marked improvement in JOA score and leg pain VAS was observed in the surgery group compared with the condoliase group (P < .001, mixed-effects model). However, 3 months and 1 year after treatment, the differences were not significant. In contrast, disc height reduction was significantly greater in the condoliase group than in the surgery group at 3 months and 1 year after treatment (P < .001, mixed-effects model). Condoliase treatment was identified as an independent risk factor for progression of disc degeneration (odds ratio, 23.60; P = .001, logistic regression analysis).ConclusionCondoliase treatment demonstrated mid-term efficacy comparable to surgical treatment; however, it required more time for pain relief and was potentially associated with progression of disc degeneration.

DOI： 10.1177/21925682251377726

PubMed
Changes in performance status and predictive factors for poor improvement following surgery for spinal metastasis: a nationwide multicenter prospective cohort study

Akinobu Suzuki, Koji Tamai, Shinji Takahashi, Masayoshi Iwamae, Hiroshi Taniwaki, Yuki Shiratani, Takaki Shimizu, Kenichiro Kakutani, Yutaro Kanda, Hiroyuki Tominaga, Ichiro Kawamura, Masayuki Ishihara, Masaaki Paku, Yohei Takahashi, Toru Funayama, Kousei Miura, Eiki Shirasawa, Hirokazu Inoue, Atsushi Kimura, Takuya Iimura, Hiroshi Moridaira, Hideaki Nakajima, Shuji Watanabe, Koji Akeda, Norihiko Takegami, Kazuo Nakanishi, Hirokatsu Sawada, Koji Matsumoto, Masahiro Funaba, Hidenori Suzuki, Haruki Funao, Tsutomu Oshigiri, Takashi Hirai, Bungo Otsuki, Kazu Kobayakawa, Koji Uotani, Hiroaki Manabe, Shinji Tanishima, Ko Hashimoto, Chizuo Iwai, Daisuke Yamabe, Akihiko Hiyama, Shoji Seki, Yuta Goto, Masashi Miyazaki, Kazuyuki Watanabe, Toshio Nakamae, Takashi Kaito, Hiroaki Nakashima, Narihito Nagoshi, Satoshi Kato, Shiro Imagama, Kota Watanabe, Gen Inoue, Takeo Furuya

The Spine Journal 26 ( 2 ) 386 - 399 2026.02（ ISSN:15299430 ）

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Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.spinee.2025.10.028

PubMed
研究者の最新動向　WHERETOプロジェクトに基づく健康寿命地域差の要因分析　超高齢社会における整形外傷医療の新たな視点

玉井孝司, 中村博亮, 池渕充彦, 高橋真治, 岩前真由, 樋口由美, 上村一貴, 上田将也, 岡崎和伸, 横山久代, 川端悠, 寺井秀富

Precision Medicine 9 ( 2 ) 144 - 148 2026.02（ ISSN:2434-3625 ）

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超高齢社会において転倒・骨折は健康寿命短縮の主要因である。本研究は,大阪公立大学と大阪府・大阪市が連携して推進するプロジェクトの一環として,健康寿命が短い地域(大阪府)と長い地域(三重県・山梨県)の高齢者を対象に,転倒・骨折につながりうる生活習慣および社会的背景の違いを解析した。オンライン調査に基づく横断解析の結果,社会参加,単独外出,連続歩行,嚥下関連項目に有意な地域差が認められた。これらの知見は,健康寿命の延伸に向けて,転倒・骨折の前段階に介入する整形外傷医療の重要性を示唆する。(著者抄録)
Risk factors for cage subsidence following anterior-posterior spinal fixation in osteoporotic vertebral fractures: a multicenter retrospective study.

Kinoshita Y, Takahashi S, Yasuda H, Terakawa M, Konishi S, Kato M, Toyoda H, Suzuki A, Tamai K, Yabu A, Sawada Y, Iwamae M, Okamura Y, Kobayashi Y, Uematsu M, Taniwaki H, Nakamura H, Terai H

Asian spine journal 2026.01（ ISSN:1976-1902 ）

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DOI： 10.31616/asj.2025.0454

PubMed
Neurological Recovery Trajectories in Older Patients with Cervical Spinal Cord Injury: A Multicenter Longitudinal Study

Hirota Ryosuke, Terashima Yoshinori, Emori Makoto, Teramoto Atsushi, Yokogawa Noriaki, Sasagawa Takeshi, Nakashima Hiroaki, Segi Naoki, Ito Sadayuki, Funayama Toru, Eto Fumihiko, Yamaji Akihiro, Watanabe Kota, Nori Satoshi, Takeda Kazuki, Furuya Takeo, Yunde Atsushi, Nakajima Hideaki, Yamada Tomohiro, Hasegawa Tomohiko, Suzuki Hidenori, Imajo Yasuaki, Ikegami Shota, Uehara Masashi, Tonomura Hitoshi, Sakata Munehiro, Hashimoto Ko, Onoda Yoshito, Suzuki Nobuyuki, Kato Kenji, Uei Hiroshi, Sawada Hirokatsu, Nakanishi Kazuo, Misaki Kosuke, Terai Hidetomi, Tamai Koji, Kuroda Akiyoshi, Inoue Gen, Iizuka Yoichi, Takasawa Eiji, Akeda Koji, Takegami Norihiko, Funao Haruki, Oshima Yasushi, Kaito Takashi, Sakai Daisuke, Yoshii Toshitaka, Seki Shoji, Okada Seiji, Imagama Shiro, Kato Satoshi

Spine Surgery and Related Research advpub ( 0 ) 2026（ eISSN:2432261X ）

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Introduction: This study aimed to characterize neurological recovery trajectories in patients with cervical spinal cord injury, aged ≥65 years.Methods: This retrospective multicenter cohort study used registry data from the Japan Association of Spine Surgeons with Ambition. Patients aged ≥65 years with traumatic cervical spinal cord injury and complete International Standards for Neurological Classification of Spinal Cord Injury motor score data at baseline, 6 weeks, and 6 months post-injury, were included (n = 222). Neurological assessments included total, upper extremity, and lower extremity motor scores; the American Spinal Injury Association Impairment Scale (AIS) and motor zone of partial preservation. Motor recovery and AIS conversion were analyzed based on baseline and 6-week AIS grades.Results: Motor recovery occurred predominantly within the first 6 weeks after injury. From baseline to 6 weeks, patients with baseline AIS B and C exhibited significantly greater improvement in total motor score than those with AIS A and D. From 6 weeks to 6 months, measurable recovery persisted in patients with AIS C at 6 weeks, whereas those with AIS A or B demonstrated minimal additional gains. AIS conversion followed a similar pattern: 38.5%, 63.6%, and 82.7% among patients with baseline AIS A, B, and C, respectively, which improved by 6 weeks, whereas conversions beyond 6 weeks were uncommon. Among patients who remained AIS A or B at 6 months, motor zone of partial preservation extension occurred almost exclusively within the first 6 weeks.Conclusions: In older patients with cervical spinal cord injury, most neurological recovery under routine clinical practice occurs within the first 6 weeks after injury. The magnitude of motor recovery and AIS conversion in this cohort was comparable to outcomes reported in age-unrestricted populations, suggesting that meaningful early neurological recovery can be observed even in older patients and highlighting the importance of early neurological assessment.

DOI： 10.22603/ssrr.2026-0064

CiNii Research
Delayed-Onset C1 Myelopathy after Cervical Laminoplasty

Kobayashi Yuto, Tamai Koji, Kato Minori, Toyoda Hiromitsu, Suzuki Akinobu, Takahashi Shinji, Sawada Yuta, Iwamae Masayoshi, Okamura Yuki, Uematsu Masato, Taniwaki Hiroshi, Sasaki Ryo, Kinoshita Yuki, Suzuki Maya, Tsujino Masashi, Nakamura Hiroaki, Terai Hidetomi

Spine Surgery and Related Research advpub ( 0 ) 2026（ eISSN:2432261X ）

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DOI： 10.22603/ssrr.2026-0101

CiNii Research
Deep learning algorithm for identifying osteopenia/osteoporosis using cervical radiography

Tamai K.

Scientific Reports 15 ( 1 ) 25274 2025.12

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DOI： 10.1038/s41598-025-11285-3

PubMed
Characterizing stroke-related cellular changes in the surviving neurons of mouse ischemic stroke

Ikegami T.

Neurochemistry International 191 106086 2025.12（ ISSN:01970186 ）

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DOI： 10.1016/j.neuint.2025.106086

PubMed
Effect of Preoperative Nutritional Status on Postoperative Clinical Outcomes of Patients With Metastatic Spinal Tumors: Japan Association of Spine Surgeons With Ambition Multicenter Study.

Masafumi Kawai, Satoshi Kato, Noriaki Yokogawa, Takaki Shimizu, Satoru Demura, Yuki Shiratani, Akinobu Suzuki, Koji Tamai, Kenichiro Kakutani, Yutaro Kanda, Hiroyuki Tominaga, Ichiro Kawamura, Masayuki Ishihara, Masaaki Paku, Toru Funayama, Kousei Miura, Eiki Shirasawa, Hirokazu Inoue, Atsushi Kimura, Kazuo Nakanishi, Hirokatsu Sawada, Koji Matsumoto, Masahiro Funaba, Hidenori Suzuki, Koji Akeda, Norihiko Takegami, Takuya Iimura, Hiroshi Moridaira, Hideaki Nakajima, Tsutomu Oshigiri, Takashi Hirai, Bungo Otsuki, Kazu Kobayakawa, Haruki Funao, Koji Uotani, Shinji Tanishima, Koichi Sairyo, Ko Hashimoto, Chizuo Iwai, Shoji Seki, Masashi Miyazaki, Kazuyuki Watanabe, Toshio Nakamae, Takashi Kaito, Hiroaki Nakashima, Narihito Nagoshi, Shiro Imagama, Kota Watanabe, Gen Inoue, Takeo Furuya

Spine 50 ( 22 ) 1571 - 1580 2025.11（ ISSN:03622436 ）

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Publishing type：Research paper (scientific journal) International / domestic magazine：International journal

STUDY DESIGN: A multicenter prospective study. OBJECTIVE: To evaluate the effect of preoperative nutritional status, assessed using the prognostic nutritional index (PNI), on clinical outcomes, including survival prognosis, postoperative complications, hospitalization duration, and functional prognosis, in patients with metastatic spinal tumors undergoing surgery. SUMMARY OF BACKGROUND DATA: Malnutrition is common in patients with cancer and is associated with poor clinical outcomes. However, data on the role of nutritional status in metastatic spinal tumors are limited. METHODS: We included 309 patients who underwent surgery for metastatic spinal tumors between October 2018 and March 2021. Patients were divided into two groups: normal nutrition (PNI ≥40) and malnutrition (PNI <40). Clinical outcomes, including 1-year mortality, postoperative complications, and functional improvements (performance status, Frankel grade, Barthel index, vitality index, and EuroQol 5-dimension 5-level), were compared using propensity score matching to adjust for confounding factors, such as age, sex, preoperative chemotherapy, performance status, primary tumor type, and visceral metastases. RESULTS: Thirty-six percent of patients were malnourished. After propensity score matching, the malnutrition group had a significantly higher mortality rate within 1 year than the normal nutrition group (55% vs. 31%, P <0.001) and showed limited physical improvement, including neurological recovery, one month postoperatively. However, improvements in motivation and quality of life (QOL) were comparable between the groups, and physical function recovery at six months was similar. No significant differences in postoperative complications or length of hospital stay were observed between the groups. CONCLUSIONS: Preoperative malnutrition was observed in 36% of patients with metastatic spinal tumors who underwent surgery and was associated with a poor postoperative survival prognosis and delayed physical recovery. However, surgical treatment improved motivation, QOL, and physical function six months after surgery. These findings highlight the importance of assessing the nutritional status preoperatively and considering both survival and functional prognoses when selecting surgical treatment for patients with malnutrition.

DOI： 10.1097/BRS.0000000000005487

PubMed
Canadian Spine Society: 25th Annual Scientific Conference, February 25 to 28, 2025, Fairmont Le Manoir Richelieu, La Malbaie, Charlevoix, Que., Canada

Chan V.

Canadian Journal of Surgery Journal Canadien De Chirurgie 68 ( 6suppl3 ) S58 - S132 2025.11（ ISSN:0008-428X ）

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DOI： 10.1503/cjs.020125

PubMed
Predicting osteoporosis-related complications in lumbar spine surgery using Hounsfield unit and vertebral bone quality scores: A 5-Year follow-up study with principal component analysis insights

Kinoshita Y.

European Spine Journal 34 ( 11 ) 5148 - 5156 2025.11（ ISSN:09406719 ）

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DOI： 10.1007/s00586-025-09298-7

PubMed
Machine Learning-Based Prediction of Quality of Life Improvement After Surgery for Spinal Metastases: A Prospective Multicenter Study.

Kyota Kitagawa, Satoshi Maki, Yuki Shiratani, Akinobu Suzuki, Koji Tamai, Takaki Shimizu, Kenichiro Kakutani, Yutaro Kanda, Hiroyuki Tominaga, Ichiro Kawamura, Masayuki Ishihara, Masaaki Paku, Yohei Takahashi, Toru Funayama, Kousei Miura, Eiki Shirasawa, Hirokazu Inoue, Atsushi Kimura, Takuya Iimura, Hiroshi Moridaira, Hideaki Nakajima, Shuji Watanabe, Koji Akeda, Norihiko Takegami, Kazuo Nakanishi, Hirokatsu Sawada, Koji Matsumoto, Masahiro Funaba, Hidenori Suzuki, Haruki Funao, Tsutomu Oshigiri, Takashi Hirai, Bungo Otsuki, Kazu Kobayakawa, Koji Uotani, Koichi Sairyo, Shinji Tanishima, Ko Hashimoto, Chizuo Iwai, Daisuke Yamabe, Akihiko Hiyama, Shoji Seki, Kenji Kato, Masashi Miyazaki, Kazuyuki Watanabe, Toshio Nakamae, Takashi Kaito, Hiroaki Nakashima, Narihito Nagoshi, Satoshi Kato, Shiro Imagama, Kota Watanabe, Seiji Ohtori, Gen Inoue, Takeo Furuya

Spine 50 ( 20 ) 1410 - 1419 2025.10（ ISSN:03622436 ）

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Publishing type：Research paper (scientific journal) International / domestic magazine：International journal

STUDY DESIGN: A prospective multicenter cohort study. OBJECTIVE: To develop and validate machine learning models for predicting health-related quality of life (HRQoL) improvements in patients after one month and six months of surgery for spinal metastases. SUMMARY OF BACKGROUND DATA: The prediction of postoperative HRQoL of spinal metastases surgery remains understudied compared with studies of survival outcomes. METHODS: We analyzed data from 413 patients who underwent surgery for spinal metastases at 40 participating institutions in Japan. The primary outcome was HRQoL improvement, defined as an increase in the EuroQol 5-Dimension 5-Level (EQ-5D) utility value of ≥0.32 from baseline. We developed two models for 1-month (n=360) and 6-month (n=189) outcomes using various machine learning algorithms. Missing values were imputed, and feature selection was performed using recursive feature elimination with cross-validation. We split the data into training (80%) and test (20%) sets for each model. Model performance was evaluated using the area under the receiver operating characteristic curve (AUC), accuracy, precision, and F1-score. SHapley Additive exPlanations (SHAP) analysis was used to interpret feature importance. RESULTS: The 6-month model outperformed the 1-month model across all metrics. For 1-month predictions, Logistic Regression achieved an AUC of 0.8136 and an accuracy of 0.7639 on the test set. For 6-month predictions, Naive Bayes demonstrated an AUC of 0.8928 and an accuracy of 0.8684. The 1-month model used 12 features, while the 6-month model required seven. SHAP analysis revealed that EQ-5D Mobility was the most influential feature in both models. CONCLUSIONS: Our models demonstrate high predictive accuracy for HRQoL improvements following spinal metastases surgery, with superior performance of the 6-month model. These models could enhance clinical decision-making and patient counseling by providing personalized predictions of postoperative QoL. Future research should focus on external validation and integration of these models into clinical practice.

DOI： 10.1097/BRS.0000000000005367

PubMed
Characteristics and Clinical Outcomes of Transition from Conservative Therapy to Surgical Intervention in Older Patients with Cervical Spinal Cord Injury without Major Bone Injury: A Nationwide Retrospective Study

Yokogawa Noriaki, Sasagawa Takeshi, Hayashi Hiroyuki, Demura Satoru, Nakashima Hiroaki, Segi Naoki, Watanabe Kota, Nori Satoshi, Funayama Toru, Eto Fumihiko, Nakajima Hideaki, Furuya Takeo, Yunde Atsushi, Terashima Yoshinori, Hirota Ryosuke, Yamada Tomohiro, Hasegawa Tomohiko, Suzuki Hidenori, Imajo Yasuaki, Kawaguchi Kenichi, Haruta Yohei, Tonomura Hitoshi, Sakata Munehiro, Terai Hidetomi, Tamai Koji, Inoue Gen, Ikegami Shota, Akeda Koji, Nakanishi Kazuo, Uei Hiroshi, Funao Haruki, Oshima Yasushi, Yoshii Toshitaka, Hashimoto Ko, Iizuka Yoichi, Kiyasu Katsuhito, Ishihara Masayuki, Kaito Takashi, Okada Seiji, Imagama Shiro, Kato Satoshi

Spine Surgery and Related Research 9 ( 5 ) 530 - 538 2025.09（ eISSN:2432261X ）

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Introduction: Cervical spinal cord injury (CSCI) without major bone injury is increasing among older adults, particularly in aging societies like Japan. The optimal treatment strategies remain unclear, with conservative therapy often preferred, especially for older patients. However, surgery is frequently necessary due to poor improvement or progression of paralysis during conservative treatment. This study investigated the characteristics and outcomes of older patients with CSCI without major bone injury who transitioned from conservative treatment to surgery.Methods: This nationwide, retrospective study examined data from patients aged ≥65 years with CSCI without major bone injury. The patients were categorized into 3 groups: conservative treatment, planned surgery, and those who switched from conservative treatment to surgery. The study aimed to identify the risk factors for conservative therapy failure that necessitate surgical intervention and to compare the outcomes between patients who had planned surgery and those who required surgery after conservative management failed.Results: Among 615 patients, 422 (68.6%) received conservative treatment, 193 (31.4%) had planned surgery, and 116 (18.9%) transitioned from conservative to surgical treatment. Transition to surgery was mainly due to poor improvement or progression of neurological deficits. Significant risk factors for transitioning to surgery included younger age, presence of ossification of the posterior longitudinal ligament, and spinal cord signal changes on magnetic resonance imaging. Comparative analysis showed no significant differences in neurological outcomes between patients who had surgery as planned and those who required surgery after failed conservative treatment.Conclusions: A significant proportion of older patients with CSCI without major bone injury who were initially managed conservatively eventually required surgery due to insufficient neurological improvement. The outcomes of patients who transitioned to surgery were similar to those who had surgery as initially planned, indicating that careful monitoring of conservative treatment followed by surgery, if necessary, may be an effective approach.

DOI： 10.22603/ssrr.2024-0291

PubMed

CiNii Research
Learning curve in the introduction of endoscopic laminectomy

AKAI Yasuaki

The Central Japan Journal of Orthopaedic Surgery & Traumatology 68 ( 5 ) 655 - 656 2025.09（ ISSN:00089443 ）（ eISSN:13490885 ）

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DOI： 10.11359/chubu.2025.655

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Impact of Antiplatelet Medication Continuation on Surgical Outcomes after Minimally Invasive Posterior Lumbar Decompression Surgery: Retrospective Cohort Study.

Yuta Sawada, Koji Tamai, Hiromitsu Toyoda, Minori Kato, Akinobu Suzuki, Shinji Takahashi, Masayoshi Iwamae, Yuki Okamura, Yuto Kobayashi, Hiroaki Nakamura, Hidetomi Terai

Global spine journal 15 ( 7 ) 3065 - 3072 2025.09（ ISSN:21925682 ）

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Publishing type：Research paper (scientific journal) International / domestic magazine：International journal

Study DesignRetrospective cohort study.ObjectivesSpinal surgeons face a dilemma regarding the continuation or discontinuation of antiplatelet agents during the perioperative period. Guidelines recommend considering the balance between thrombotic and bleeding risks. However, no consensus exists for the use of these agents for patients who undergo minimally invasive lumbar decompression. This study aimed to assess the effect of continued antiplatelet medication on minimally invasive posterior lumbar decompression surgery outcomes, focusing on perioperative outcomes and 1-year postoperative clinical results.MethodsThis study included 106 patients who underwent minimally invasive posterior lumbar decompression between 2017 and 2022 and were taking antiplatelet medications before spinal surgery. Patient characteristics, antiplatelet medication type, and perioperative data were analyzed. Patients were divided into "continuation" and "discontinuation" groups based on preoperative antiplatelet medication status. Univariate and multivariate linear regression analyses were performed.ResultsNo significant differences were observed between groups in terms of surgical time, intraoperative blood loss, postoperative drain volume, complication rates, and Japanese Orthopedic Association scores and EuroQoL-5 dimensions 5-level at 1 year postoperatively. Similar results were noted in groups focusing exclusively on patients treated with aspirin. Multivariate linear regression revealed that surgical time per level was significantly associated with total blood loss, whereas antiplatelet medications did not show a significant relationship (operative time per level, P < 0.01; antiplatelet drugs, P = 0.459).ConclusionsThis study suggests that minimally invasive posterior lumbar spine decompression can be performed safely and effectively under continuous antiplatelet medication. Further studies with more evidence are required to validate our findings.

DOI： 10.1177/21925682251318266

PubMed
内視鏡下椎弓切除術導入におけるラーニングカーブ　UBE/BESS vs.MEL

赤井靖明, 加藤相勲, 玉井孝司, 高橋真治, 鈴木亨暢, 寺井秀富

中部日本整形外科災害外科学会雑誌 68 ( 5 ) 655 - 656 2025.09（ ISSN:0008-9443 ）

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腰部脊柱管狭窄症に対し内視鏡下椎弓切除術を施行した67例をUBE/BESS群28例、MEL群39例に分け、ラーニングカーブを比較検討した。その結果、両群のラーニングカーブは類似しており、術後成績も同等であった。本検討ではUBE/BESSを担当した術者は既にMELの手技を習熟していたため、UBE/BESSを早期に習得できた可能性が考えられた。
A deep learning-based prediction model for prognosis of cervical spine injury: a Japanese multicenter survey

Ito S.

European Spine Journal 34 ( 9 ) 3714 - 3723 2025.09（ ISSN:09406719 ）

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DOI： 10.1007/s00586-025-08708-0

PubMed
Characteristics and Clinical Outcomes of Transition from Conservative Therapy to Surgical Intervention in Older Patients with Cervical Spinal Cord Injury without Major Bone Injury: A Nationwide Retrospective Study(タイトル和訳中)

Yokogawa Noriaki, Sasagawa Takeshi, Hayashi Hiroyuki, Demura Satoru, Nakashima Hiroaki, Segi Naoki, Watanabe Kota, Nori Satoshi, Funayama Toru, Eto Fumihiko, Nakajima Hideaki, Furuya Takeo, Yunde Atsushi, Terashima Yoshinori, Hirota Ryosuke, Yamada Tomohiro, Hasegawa Tomohiko, Suzuki Hidenori, Imajo Yasuaki, Kawaguchi Kenichi, Haruta Yohei, Tonomura Hitoshi, Sakata Munehiro, Terai Hidetomi, Tamai Koji, Inoue Gen, Ikegami Shota, Akeda Koji, Nakanishi Kazuo, Uei Hiroshi, Funao Haruki, Oshima Yasushi, Yoshii Toshitaka, Hashimoto Ko, Iizuka Yoichi, Kiyasu Katsuhito, Ishihara Masayuki, Kaito Takashi, Okada Seiji, Imagama Shiro, Kato Satoshi

Spine Surgery and Related Research 9 ( 5 ) 530 - 538 2025.09

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重大な骨損傷を伴わない日本人高齢頸髄損傷(CSCI)について、保存的治療から外科的介入へ移行した患者の特徴と転帰を調べる後ろ向き研究を行った。2010年～2020年の国内65歳以上適合症例615例を対象とした。このうち、422例(68.6%)が保存的治療を、193例(31.4%)が計画的手術を(計画的手術群)、116例(18.9%)が保存的治療から外科的介入移行を(介入移行群)、それぞれ受けた。介入移行の理由は、神経学的障害改善不良(68例、58.6%)または増悪(13例、11.2%)があげられた。介入移行における有意なリスク因子は、受傷時年齢の低さ、後縦靱帯骨化症、MRIでの脊髄信号変化であった。術後6ヵ月後の臨床転帰について、計画的手術群と介入移行群を傾向スコアマッチングして分析したところ、有意な群間差を認めなかった。以上より、保存的治療を受けた高齢CSCI患者をモニタリングし、適切なタイミングで外科的介入を行う有効性が示唆された。
The Risk of Intravenous Cement Leakage and Short-term Outcomes of Selective Cement-augmented Pedicle Screws: A Multicenter Retrospective Study.

Shinji Takahashi, Daisuke Sakai, Shota Ogasawara, Ryo Sasaki, Masato Uematsu, Takahiko Hyakumachi, Akihiko Hiyama, Hiroyuki Katoh, Hidetomi Terai, Akinobu Suzuki, Koji Tamai, Hiroaki Nakamura, Mitsuru Yagi

Clinical spine surgery 38 ( 7 ) E419 - E424 2025.08（ ISSN:23800186 ）

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Publishing type：Research paper (scientific journal) International / domestic magazine：International journal

STUDY DESIGN: Multicenter retrospective cohort study. OBJECTIVE: To evaluate the efficacy and safety of using cement-augmented pedicle screw (CAPS) fixation only for the cephalad and caudal vertebral bodies. SUMMARY OF BACKGROUND DATA: Pedicle screw fixation is less effective in patients with low-quality bone. Although CAPS fixation has shown promise in improving stability and reducing screw loosening in such cases, cement leakage can have serious consequences. METHODS: This study included 65 patients who underwent spinal surgery using CAPS and were followed up for >3 months. Four CAPSs were used in each patient, and 254 CAPSs were included in the analysis. RESULTS: Of the 65 patients, 36.9% showed intravenous cement leakage, and a low bone mineral density (BMD) was associated with a higher risk of cement leakage. The use of a CAPS on the right side was also potentially associated with a higher risk of leakage. However, the shape and location of the leaked cement remained stable over time. Screw loosening occurred in 3.5% of the CAPSs and was associated with a lower cement volume. CONCLUSION: Cement leakage was related to lower BMD. Using CAPS exclusively at the lower or upper instrumentation levels might minimize the risk of cement leakage in osteoporotic patients.

DOI： 10.1097/BSD.0000000000001757

PubMed
Effect of romosozumab administration on proximal junctional kyphosis in corrective spinal fusion surgery.

Yuta Sawada, Shinji Takahashi, Hiroyuki Yasuda, Masaki Terakawa, Sadahiko Konishi, Minori Kato, Hiromitsu Toyoda, Akinobu Suzuki, Koji Tamai, Masayoshi Iwamae, Yuki Okamura, Yuto Kobayashi, Hiroaki Nakamura, Hidetomi Terai

The spine journal : official journal of the North American Spine Society 25 ( 6 ) 1218 - 1228 2025.06（ ISSN:15299430 ）

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Publishing type：Research paper (scientific journal) International / domestic magazine：International journal

BACKGROUND CONTEXT: The effect of romosozumab administration in patients undergoing corrective spinal fusion surgery has not yet been analyzed. PURPOSE: To examine the effect of romosozumab administration on reducing the incidence of proximal junctional kyphosis (PJK), particularly PJK due to fractures (PJK-Fx), in patients undergoing spinal corrective fusion surgery. DESIGN: Retrospective cohort study. PATIENT SAMPLE: A total of 111 patients aged >50 years underwent corrective fusion surgery (>2 vertebrae) for adult spinal deformity or vertebral compression fracture between June 2010 and July 2023. OUTCOME MEASURES: The primary outcome was the incidence of PJK, whereas the secondary outcomes were changes in Hounsfield unit (HU) values, surgical complications, and clinical outcomes measured using the Japanese Orthopaedic Association (JOA) and visual analog scale scores. METHODS: The patients were divided into the romosozumab (n=32) and nonromosozumab groups (n=79). Romosozumab was typically administered 2 months before surgery in the romosozumab group. Demographic data, surgery-related factors, and radiographic parameters were analyzed. HU values at the upper instrumented vertebra+1 (UIV+1) were measured preoperatively and at 1 year postoperatively. After the univariate analysis of preoperative factors associated with PJK, multivariate logistic regression was used to identify factors associated with PJK. RESULTS: Romosozumab significantly increased the HU values at UIV+1 (-1.22% vs 13.60%, p<.001) and reduced the incidence of PJK (39.24% vs 18.75%, p=.046), particularly PJK-Fx (26.58% vs 6.25%, p=.019) and osteoporosis-related complications (55.70% vs 34.38%, p=.011). The multivariate analysis showed a significantly lower incidence of PJK (adjusted odds ratio = 0.32, p=.033), particularly PJK-Fx (adjusted odds ratio = 0.15, p=.018). There was a tendency for better JOA scores at 1 year postoperatively in the romosozumab group (21.49 vs 23.62, p=.071). CONCLUSION: Romosozumab administration effectively increased bone density and reduced the risk of PJK, particularly PJK-Fx, and osteoporosis-related complications in patients undergoing corrective spinal fusion surgery. Administration of romosozumab 2 months before surgery enhanced bone mineral density and strength, leading to better surgical outcomes and fewer complications. Further long-term studies are needed to confirm these findings and optimize treatment protocols.

DOI： 10.1016/j.spinee.2024.12.021

PubMed
"Koshimagari Exercise" for Adult Spinal Deformity in Older Adults: Assessment of Home-Based Exercise Outcomes in a Prospective Multicenter Study

Terai Hidetomi, Takahashi Shinji, Hoshino Masatoshi, Taniwaki Hiroshi, Tamai Koji, Ohmine Toshimitsu, Nakatsuchi Tamotsu, Shinbashi Goya, Teraguchi Masatoshi, Minetama Masakazu, Watanabe Kei, Sato Naritoshi, Kitamura Takuya, Kanda Masaru, Tsujio Tadao, Takeuchi Yuichi, Mizouchi Tatsuki, Ishizu Katsuhito, Ebina Toshihito, Muraoka Yasunari, Sodeyama Tomonori, Mikami Hiroshi, Kasukawa Yuji, Hyakumachi Takahiko, Ishida Kazuhiro, Miyagishima Kazufumi, Oishi Yosuke, Yo Kiyonori, Kimura Ryota, Sato Hiromichi, Nagata Keiji, Yamato Yu, Matsudaira Ko, Miyakoshi Naohisa, Matsuyama Yukihiro, Haro Hirotaka, Hashizume Hiroshi, Yamada Hiroshi, Kaito Takashi, Project Committee of the Japanese Society for Spine Surgery and Related Research (JSSR)

Spine Surgery and Related Research 9 ( 3 ) 358 - 367 2025.05（ eISSN:2432261X ）

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Introduction: Adult spinal deformity (ASD) is prevalent among older adults, considerably affecting their quality of life. Although surgical interventions are effective, they have high complication rates and medical costs. Furthermore, there is a lack of evidence supporting the effectiveness of nonsurgical treatments (e.g., physical therapy) in patients with ASD. This study aimed to investigate the impact of "Koshimagari exercise," a specific home-based exercise regimen designed for patients with ASD, and to evaluate its effects on clinical outcomes in older adults.Methods: A total of 144 participants aged 50-80 years with chronic low back pain (LBP) due to spinal deformities were included in this multicenter prospective study. Qualified physiotherapists conducted intervention sessions at the hospital once a week, and self-exercise was performed at home three times a week. After 3 months, the frequency of self-exercise at home increased to four times a week. Clinical evaluations were conducted using the Oswestry Disability Index (ODI), five-level classification system of EuroQol-5 Dimensions (EQ-5D), Japanese edition of Scoliosis Research Society-22r (SRS-22r), and visual analog scale (VAS) for LBP at baseline and 3, 6, and 12 months. Radiographic evaluations were performed in standing and supine positions.Results: Of 130 participants who provided written informed consent, 98 completed the 6-month follow-up and were included in the analysis. Significant improvements observed in ODI, EQ-5D, and VAS scores were observed at 3 months, with SRS-22r scores improving throughout the study period. Radiographically, there were significant differences in the sagittal vertical axis and pelvic tilt at 12 months. Sufficient compliance with the self-exercise program was reported by 96%, 86%, and 73% of participants at 3, 6, and 12 months, respectively.Conclusions: The "Koshimagari Exercise" program led to significant short-term improvements in health-related quality of life and pain among elderly patients with ASD. This home-based self-exercise program is an excellent nonsurgical treatment option for patients with ASD.

DOI： 10.22603/ssrr.2024-0273

PubMed

CiNii Research
Clinical and Economic Outcomes of Intradiscal Injection of Condoliase for a Treatment of Lumbar Disc Herniation with Severe Low Back Pain: A Multicenter Study

Hirai Takashi, Takahashi Takuya, Takahashi Yohei, Watanabe Kota, Banno Tomohiro, Sakaki Kyohei, Arai Yoshiyasu, Takano Yuichi, Eguchi Yawara, Taniguchi Yuki, Maki Satoshi, Aoki Yasuchika, Fujii Shunichi, Sakaeda Kentaro, Matsukura Yu, Akazawa Tsutomu, Minamide Akihito, Nojiri Hidetoshi, Sakai Kenichiro, Kato Satoshi, Tamai Koji, Suzuki Hidekazu, Miyagi Masayuki, Sato Hiroyuki, Yoshii Toshitaka, Yamada Hiroshi, Kaito Takashi, Hiraizumi Yutaka, Yamagata Masatsune, Nakamura Masaya, Hirakawa Akihiro, Hosogane Naofumi, Ohtori Seiji

Spine Surgery and Related Research 9 ( 3 ) 368 - 374 2025.05（ eISSN:2432261X ）

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Introduction: Chemonucleolysis with condoliase (chondroitin sulfate ABC endolyase) has been widely employed to treat patients with lumbar disc herniation (LDH) in Japan. Although it is an effective and relatively safe treatment for radicular neuropathy in patients with LDH, there have been no reports that investigate how severe low back pain (LBP) changes after condoliase injection. In this multicenter study, the effectiveness of condoliase injection for reducing severe LBP in patients with LDH was evaluated.Methods: This retrospective study involved patients treated with intradiscal condoliase injection for LDH at nine participating centers. Patients were diagnosed with subligamentous-type herniation based on pretreatment MRI. Patients with severe LBP (defined as a preinjection numeric rating scale [NRS] for LBP greater than or equal to that for leg pain) were categorized into the LBP group. Demographic data, adverse events, treatment costs, and the NRS for LBP and lower extremity pain were analyzed. A 50% response was defined as ≥50% improvement in the NRS at 1 year postinjection. On the basis of the Pfirman classification, the LBP group was divided into less-degenerative (Grades II and III) and degenerative (Grades IV and V) subgroups.Results: Seventy-nine patients were classified into the LBP group. Of these patients, 61 (77.2%) showed a >50% reduction in LBP, and another 61 (77.2%) demonstrated a >50% reduction in lower extremity pain. Improvement of lower limb pain was considerably better in the less-degenerative group than in the degenerative group, whereas that of low back pain was similar between the two subgroups. Medical costs, which include remuneration for injection, drug fees, inpatient costs, and other expenses, were similar between the LBP group and all cases.Conclusions: This retrospective multicenter study revealed that patients with LDH with severe LBP frequently experienced improvement in radicular pain and LBP, which is similar to LDH cases without severe LBP.

DOI： 10.22603/ssrr.2024-0288

PubMed

CiNii Research
特集整形外科領域におけるAIの応用 Ⅱ章.AIによる画像診断 1.AI技術を活用した脊椎画像診断

藪晋人, 高橋真治, 玉井孝司, 星野雅俊, 寺井秀富

整形外科 76 ( 6 ) 517 - 523 2025.05（ ISSN:00305901 ）（ eISSN:24329444 ）

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DOI： 10.15106/j_seikei76_517

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【整形外科領域におけるAIの応用】(II章)AIによる画像診断　AI技術を活用した脊椎画像診断

藪晋人, 高橋真治, 玉井孝司, 星野雅俊, 寺井秀富

整形外科 76 ( 6 ) 517 - 523 2025.05（ ISSN:0030-5901 ）

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＜文献概要＞はじめに　本邦において,脊椎疾患は高齢化や生活習慣の変化に伴い,増加傾向にある.働き盛りの年齢層から高齢者にいたるまで幅広くみられ,生活の質の低下や介護リスクの増大を招く要因となる.そのため,適切な治療介入が求められる一方で,診断の質を確保することが喫緊の課題である.中でも,画像診断は診断過程においてきわめて重要な役割を担っているが,その解釈は医師の知識や経験に大きく依存しており,軽微な病変や複雑な構造を正確に読み取るには時間と労力を要する.近年,AIの急速な発展により,医療現場におけるAIの活用が注目されている.特にヒトの視覚を模したアルゴリズムである畳み込みニューラルネットワーク(convolutional neural network:CNN)は物体認識やパターン認識に優れ,画像診断との親和性が高い.CNNによる画像解析のタスクは,大きく「分類」,「検出」,「セグメンテーション」の三つに大別される.分類では画像全体から疾患の有無や種類を判別し,検出では異常部位の位置を特定する.さらに,セグメンテーションでは病変領域をピクセル単位で詳細に抽出する(図1).脊椎外科領域においてもCNNを用いた画像診断モデルの開発がすすめられており,従来の診断精度の向上や医療従事者の負担軽減,ひいては患者への早期対応に寄与することが期待されている.本稿では,日常診療でよく遭遇する脊椎疾患の画像診断におけるAI技術の現状について文献レビューを行い,今後の展望について考察した.
高齢者の成人脊柱変形における「腰曲がり運動」　前向き多施設研究における在宅運動療法のアウトカム評価("Koshimagari Exercise" for Adult Spinal Deformity in Older Adults: Assessment of Home-Based Exercise Outcomes in a Prospective Multicenter Study)

Terai Hidetomi, Takahashi Shinji, Hoshino Masatoshi, Taniwaki Hiroshi, Tamai Koji, Ohmine Toshimitsu, Nakatsuchi Tamotsu, Shinbashi Goya, Teraguchi Masatoshi, Minetama Masakazu, Watanabe Kei, Sato Naritoshi, Kitamura Takuya, Kanda Masaru, Tsujio Tadao, Takeuchi Yuichi, Mizouchi Tatsuki, Ishizu Katsuhito, Ebina Toshihito, Muraoka Yasunari, Sodeyama Tomonori, Mikami Hiroshi, Kasukawa Yuji, Hyakumachi Takahiko, Ishida Kazuhiro, Miyagishima Kazufumi, Oishi Yosuke, Yo Kiyonori, Kimura Ryota, Sato Hiromichi, Nagata Keiji, Yamato Yu, Matsudaira Ko, Miyakoshi Naohisa, Matsuyama Yukihiro, Haro Hirotaka, Hashizume Hiroshi, Yamada Hiroshi, Kaito Takashi, Project Comittee of the Japanese Society for Spine Surgery and Related Research(JSSR)

Spine Surgery and Related Research 9 ( 3 ) 358 - 367 2025.05

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高齢者の成人脊柱変形における「腰曲がり運動」のアウトカムを検討した。脊柱変形による慢性腰痛(LBP)を呈する高齢者130例を対象に多施設前向き研究を行い、認定理学療法士が院内で週1回の運動指導を実施し、さらに在宅で週3回の運動プログラムを継続するよう指導、3ヵ月後に運動頻度を週4回とした。臨床評価項目として、Oswestry障害度指数(ODI)、EQ-5Dスコア、SRS-22r日本語版スコア、腰痛VASスコアをベースライン時と3、6、12ヵ月後に測定し、さらに立位と仰臥位にてX線学的評価を行った。6ヵ月後に評価可能であったのは98例(男性15例、女性83例、平均73.0±5.9歳)であり、平均BMIは23.3、Charlson合併症指数(CCI)は0.5、陳旧性椎体骨折を27%に認めた。ODIはベースライン時が35.3、3ヵ月後が32.3、6ヵ月後が33.0と減少し、EQ-5Dスコアはベースライン時が0.63、3ヵ月後が0.65と有意差が認められたが、6ヵ月後、12ヵ月後ではベースライン時と比較して有意差はなかった。腰痛VASスコアはベースライン時が53.1、3ヵ月後が42.8、6ヵ月後が46.0、12ヵ月後が46.2を示し、SRS-22rスコアは3ヵ月後に改善していた。また、X線学的パラメータに関してSVAとPTは12ヵ月後にベースライン時と比較して有意差が認められ、12ヵ月後の運動療法のコンプライアンスはexcellentが33%、goodが40%、fairが27%を示していた。「腰曲がり運動」によって健康関連QOLと腰痛の早期的改善が得られることが示された。
重度腰痛を伴う腰椎椎間板ヘルニアに対する椎間板内コンドリアーゼ注入の臨床的・経済的アウトカム　多施設研究(Clinical and Economic Outcomes of Intradiscal Injection of Condoliase for a Treatment of Lumbar Disc Herniation with Severe Low Back Pain: A Multicenter Study)

Hirai Takashi, Takahashi Takuya, Takahashi Yohei, Watanabe Kota, Banno Tomohiro, Sakaki Kyohei, Arai Yoshiyasu, Takano Yuichi, Eguchi Yawara, Taniguchi Yuki, Maki Satoshi, Aoki Yasuchika, Fujii Shunichi, Sakaeda Kentaro, Matsukura Yu, Akazawa Tsutomu, Minamide Akihito, Nojiri Hidetoshi, Sakai Kenichiro, Kato Satoshi, Tamai Koji, Suzuki Hidekazu, Miyagi Masayuki, Sato Hiroyuki, Yoshii Toshitaka, Yamada Hiroshi, Kaito Takashi, Hiraizumi Yutaka, Yamagata Masatsune, Nakamura Masaya, Hirakawa Akihiro, Hosogane Naofumi, Ohtori Seiji

Spine Surgery and Related Research 9 ( 3 ) 368 - 374 2025.05

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腰椎椎間板ヘルニア(LDH)患者にみられる重度腰痛に対する椎間板内コンドリアーゼ注入の有効性を検討した。MRIにて靱帯下型ヘルニアと診断され、重度腰痛を呈するLDH患者79例(男性52例、女性27例、平均44.5±19.4歳)を対象に多施設後ろ向き研究を行い、患者基礎データ、有害事象の発現、治療コスト、腰痛と下肢痛の数値化評価尺度(NRS)を評価した。なお、Pfirman分類をもとに軽度変性群(グレードII・III)と変性群(グレードIV・V)に分けた。腰痛NRSはベースライン時が7.6、12ヵ月後が2.3と減少が認められ、下肢痛NRSも12ヵ月後に著明に減少しており、NRSスコアが50%以上減少したのは腰痛が77.2%、下肢痛が77.2%となっていた。また、Pfirman分類上の軽度変性群と変性群との比較では、腰痛NRSは軽度変性群が7.1から1.9、変性群が7.5から2.3へそれぞれ減少、下肢痛NRSは軽度変性群が6.0から0.8、変性群が6.3から2.1へそれぞれ減少を示し、腰痛NRSの改善度に群間差はなかったが、下肢痛NRSの改善度は軽度変性群の方が有意に良好であった。コンドリアーゼ注入の診療報酬、薬剤費、入院費などを含めた総医療コストは130000円であった。椎間板内コンドリアーゼ注入によってLDH患者の腰痛、下肢痛に有意な改善が得られることが示された。
Risk Factors for Early 3-Month Postoperative Mortality in Metastatic Spinal Tumor Surgery: A JASA Multicenter Prospective Study.

Takaaki Uto, Satoshi Kato, Noriaki Yokogawa, Takaki Shimizu, Satoru Demura, Yuki Shiratani, Akinobu Suzuki, Koji Tamai, Kenichiro Kakutani, Yutaro Kanda, Hiroyuki Tominaga, Ichiro Kawamura, Masayuki Ishihara, Masaaki Paku, Toru Funayama, Kousei Miura, Eiki Shirasawa, Hirokazu Inoue, Atsushi Kimura, Takuya Iimura, Hiroshi Moridaira, Koji Akeda, Norihiko Takegami, Kazuo Nakanishi, Hirokatsu Sawada, Koji Matsumoto, Masahiro Funaba, Hidenori Suzuki, Hideaki Nakajima, Tsutomu Oshigiri, Takashi Hirai, Bungo Otsuki, Kazu Kobayakawa, Haruki Funao, Koji Uotani, Shinji Tanishima, Koichi Sairyo, Ko Hashimoto, Chizuo Iwai, Shoji Seki, Masashi Miyazaki, Kazuyuki Watanabe, Toshio Nakamae, Takashi Kaito, Hiroaki Nakashima, Narihito Nagoshi, Shiro Imagama, Kota Watanabe, Gen Inoue, Takeo Furuya

Spine 51 ( 1 ) 52 - 59 2025.04（ ISSN:03622436 ）

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Publishing type：Research paper (scientific journal) International / domestic magazine：International journal

STUDY DESIGN: Prospective multicenter study. OBJECTIVE: To investigate risk factors for 3-month postoperative mortality in metastatic spinal tumor surgery, focusing on nutritional biomarkers and prognostic scores alongside clinical indicators. SUMMARY OF BACKGROUND DATA: Metastatic spinal tumors affect patient morbidity and mortality. Although prognostic tools exist, they have limitations, particularly in emergency situations requiring rapid assessment. Nutritional biomarkers and prognostic scores may influence outcomes, but their role in predicting early postoperative mortality after spinal tumor surgery, particularly in prospective, multicenter studies, warrants investigation. METHODS: Data from 336 patients undergoing palliative surgery for metastatic spinal tumors were collected from 35 centers. The primary outcome was 3-month postoperative mortality. Univariate and multivariate logistic regression analyses with bootstrapping were performed to identify predictors of early mortality, including demographics, prognostic scores (revised Tokuhashi, Tomita, modified Glasgow Prognostic Score [mGPS], and the New England Spinal Metastasis Score [NESMS]), and nutritional biomarkers. The discriminative ability of these factors was evaluated using the receiver operating characteristic curve analysis. RESULTS: Results: The 3-month postoperative mortality rate was 15.5%, with primary cancer progression accounting for 54% of the deaths. Multivariate analysis revealed that high mGPS (OR=1.989, P=0.008) and low preoperative performance status (PS) (OR=1.412, P=0.034) were significant independent predictors of early mortality, the Tomita score showed a trend towards significance (OR=1.234, P=0.050). The mGPS demonstrated a high discriminative ability, with an area under the curve of 0.716. CONCLUSION: High mGPS and low preoperative PS are significant predictors of 3-month postoperative mortality in patients undergoing surgery for metastatic spinal tumors. Incorporating the mGPS, which reflects nutritional and inflammatory status, into preoperative risk stratification is crucial for optimizing surgical decision-making. LEVEL OF EVIDENCE: 2.

DOI： 10.1097/BRS.0000000000005359

PubMed
【人工知能(AI)革命-脊椎脊髄診療の将来像は?】AIを活用した骨粗鬆症性椎体骨折の予後予測

藪晋人, 高橋真治, 玉井孝司, 星野雅俊, 寺井秀富

脊椎脊髄ジャーナル 38 ( 4 ) 209 - 215 2025.04（ ISSN:0914-4412 ）

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＜文献概要＞はじめに　本邦において,骨粗鬆症性椎体骨折(osteoporotic vertebral fracture:OVF)は高齢化に伴いますます注目されている疾患であり,その発症は高齢者の日常生活活動や生活の質を著しく低下させる要因となる.多くのOVFは安静や装具といった保存的治療により骨癒合が得られるが,一部の症例では骨癒合不全や高度椎体変形をきたし,慢性腰痛や遅発性神経障害を引き起こすことがある.これらの問題は,患者にとっての負担だけでなく,医療費の増加や介護リスクの増大といった社会的コストをも伴うため,受傷早期の予後予測と適切な治療介入が重要となる.これまでに受傷時の単純X線やMRIを用いたOVFの予後予測が行われているが,さらなる精度の改善が求められる.近年,人工知能(artificial intelligence:AI)の急速な発展により,医療分野においてもAIの導入が加速している.AIは物体認識やパターン認識に優れ,画像やデータベースに登録された大量の臨床データを使用したAIによる疾病の診断や予後予測に関する研究が進められている.本稿では,われわれがAI技術の1つである機械学習モデルを活用して構築したOVFにおける骨癒合不全や椎体変形の予測モデルについて,その概要を述べるとともに,OVFの予後予測について文献的考察を行った.
特集人工知能(AI)革命-脊椎脊髄診療の将来像は? AIを活用した骨粗鬆症性椎体骨折の予後予測

藪晋人, 高橋真治, 玉井孝司, 星野雅俊, 寺井秀富

脊椎脊髄ジャーナル 38 ( 4 ) 209 - 215 2025.03（ ISSN:09144412 ）

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DOI： 10.11477/mf.091444120380040209

CiNii Research
Prognosis of Cervical Diffuse Idiopathic Skeletal Hyperostosis-Related Spine Injuries in Elderly Patients: Analyses of Both Fracture and Spinal Cord Injury Without Fracture

Segi N.

Global Spine Journal 15 ( 2 ) 321 - 331 2025.03（ ISSN:21925682 ）

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DOI： 10.1177/21925682231186757

PubMed
The Efficacy of Systemic Transdermal Diclofenac Patch for Postoperative Pain after Lumbar Spinal Surgery

Uematsu M.

Spine 50 ( 3 ) 201 - 206 2025.02（ ISSN:03622436 ）

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DOI： 10.1097/BRS.0000000000005013

PubMed
Diagnosis and Treatment of Symptomatic Multiple Sacral Perineural Cysts-Technical Note

Tsujino Masashi, Suzuki Akinobu, Terai Hidetomi, Kato Minori, Toyoda Hiromitsu, Takahashi Shinji, Tamai Koji, Nakamura Hiroaki

Spine Surgery and Related Research 9 ( 1 ) 93 - 99 2025.01（ eISSN:2432261X ）

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Introduction: Sacral perineural cysts are rarely symptomatic; however, they may occasionally cause various symptoms. As the patient exhibits multiple cysts, it often becomes difficult to determine if these cysts are symptomatic.Technical Note: Six patients with multiple sacral cysts, identified using magnetic resonance imaging (MRI), were further examined using myelography and computed tomography (CT) immediately and 6-18 h after myelography. Symptomatic cysts were exclusively diagnosed as not enhanced immediately (filling defect sign) but displayed enhancement later (delayed filling sign/retention sign) compared to the subarachnoid space. A minimal laminectomy was performed on the target cyst. The dura and epineurium with the arachnoid of the cyst were then longitudinally incised along the nerve root, and the adhesion at the junction between the cyst and the dura mater was released. The incised epineurium and dura mater were sutured using 6-0 nylon and covered with multiple layers of polyglycolic acid seat and fibrin glue. A suction drain was placed for 1 or 2 days, and the patients were mobilized on postoperative day 1. Symptoms improved in all patients; however, the improvement ratio varied. At an average follow-up of 39 months, no recurrence was observed on the MRI.Conclusions: This case series reports the diagnostic and surgical methods for multiple sacral perineural cysts and their outcomes. Delayed CT myelography is helpful in diagnosing symptomatic cysts. Moreover, all cysts with filling defect signs or delayed filling/retention signs demonstrated neural adhesions in the neck. Microsurgical fenestration and the release of adhesions are effective for the improvement of symptoms without recurrence.

DOI： 10.22603/ssrr.2024-0021

PubMed

CiNii Research
Analysis of Risk Factors for Postoperative Progressive Segment Degeneration at the Decompression and Non-decompression Segments after Minimally Invasive Lumbar Decompression Surgery: A 5-year Follow-up Study

Habibi Hasibullah, Toyoda Hiromitsu, Terai Hidetomi, Yamada Kentaro, Kato Minori, Suzuki Akinobu, Takahashi Shinji, Tamai Koji, Iwamae Masayoshi, Sawada Yuta, Kobayashi Yuto, Okamura Yuki, Nakamura Hiroaki

Spine Surgery and Related Research 9 ( 1 ) 22 - 29 2025.01（ eISSN:2432261X ）

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Publishing type：Research paper (scientific journal) International / domestic magazine：Domestic journal

Introduction: The risk factors for the development of progressive segment degeneration (PSD) after decompression surgery are still unknown. In this study, the risk factors for PSD in patients who undergo decompression surgery for lumbar spinal stenosis with and without coexisting spondylolisthesis and scoliosis were examined, focusing on decompression and non-decompression segments.Methods: We reviewed the data of patients with >5 years of postoperative follow up. Radiographic PSD was defined as either the development of an anterolisthesis or retrolisthesis of >3 mm or a decrease in disc height of >3 mm during the 5-year follow up. On the basis of intervertebral segments, the association between PSD and other preoperative clinical findings was analyzed.Results: Overall, 840 lumbar segments (L1-L2 to L5-S1) in 168 patients, with a mean age of 69.5±9.2 years, met the inclusion criteria. PSD was observed in 162 (19.3%) lumbar segments. A logistic regression model identified that Cobb angle ≥10° (OR 2.53, 95% CI 1.50-4.24), spondylolisthesis ≥3 mm (OR 4.447, 95% CI 2.06-9.58), and level of segments were more likely to have PSD at the non-decompression level; additionally, lateral listhesis ≥3 mm (OR 2.91, 95% CI 1.08-7.81) was more likely to have PSD in the decompression segments. In clinical outcomes in patients with PSD at baseline and the 5-year follow-up, no significant difference was found.Conclusions: Even though PSD does not correlate with worsening symptoms, our study confirms that a higher degree of pre-existing disc degeneration is indicative of a higher PSD in 5 years.

DOI： 10.22603/ssrr.2024-0014

PubMed

CiNii Research
Open-Door Cervical Laminoplasty Using Instrumentation of Every Level Versus Alternate Levels: A Multicenter, Randomized Controlled Trial.

Koji Tamai, Hidetomi Terai, Masaki Terakawa, Shinji Takahashi, Akinobu Suzuki, Hiroaki Nakamura

The Journal of bone and joint surgery. American volume 107 ( 2 ) 144 - 151 2025.01（ ISSN:00219355 ）

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Publishing type：Research paper (scientific journal) International / domestic magazine：International journal

BACKGROUND: In the setting of cervical open-door laminoplasty, the question of whether or not every opened laminar level should be instrumented has not been sufficiently investigated. We postulated that the surgical outcomes of open-door laminoplasty with instrumentation of every second opened level (skip-fixation) might not be inferior to those of laminoplasty with instrumentation of every opened level (all-fixation). The purpose of the present study was to test the noninferiority of laminoplasty with skip-fixation in improving myelopathy at 2 years postoperatively compared with all-fixation. Additionally, we compared radiographic and surgical outcomes between the 2 types of procedures. METHODS: This prospective, multicenter, unblinded randomized controlled trial included patients ≥60 years of age who underwent C3 to C6 open-door cervical laminoplasty for the treatment of degenerative cervical myelopathy. Patients were allocated to the skip-fixation group (n = 80) or the all-fixation group (n = 75) using a permuted block method. The primary outcome was the between-group difference in the Japanese Orthopaedic Association (JOA) score at 2 years postoperatively. Secondary outcomes included surgical data, complications, 2-year change in the JOA score, Neck Disability Index (NDI), EQ-5D-5L (EuroQol 5-dimension 5-level instrument) score, visual analog scale (VAS) score for neck pain, and radiographic outcomes. RESULTS: One hundred and thirty patients (including 66 in the skip-fixation group and 64 in the all-fixation group) completed the trial at 2 years (follow-up rate, 83.9%). The difference in the JOA score at 2 years was 0.0298 (95% confidence interval [CI], -0.706 to 0.766), which was within the noninferiority margin (p < 0.0001; noninferiority test). In the secondary analyses, laminoplasty with skip-fixation demonstrated a significantly shorter surgical time (p = 0.010; Mann-Whitney U test) and greater improvement in the VAS score for neck pain, NDI, and EQ-5D-5L score (p = 0.006, p = 0.047, p = 0.037, respectively; mixed-effect model) compared with all-fixation. There were no significant between-group differences in radiographic outcomes, including the hinge union rate. CONCLUSIONS: Skip-fixation may be sufficient to achieve noninferior 2-year postoperative improvement in myelopathy. Additionally, laminoplasty with skip-fixation potentially can lead to improvements in terms of neck pain, neck disability, and quality of life compared with all-fixation. LEVEL OF EVIDENCE: Therapeutic Level II. See Instructions for Authors for a complete description of levels of evidence.

DOI： 10.2106/JBJS.24.00245

PubMed
SPINE20 Recommendations 2024 -Spinal Disability: Social Inclusion as a Key to Prevention and Management

Menezes C.M.

Global Spine Journal 15 ( 1 ) 8 - 20 2025.01（ ISSN:21925682 ）

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DOI： 10.1177/21925682241290226

PubMed
最小侵襲腰椎除圧術後の除圧セグメントと非除圧セグメントにおける進行性区域変性症のリスク因子解析　5年間の経過観察研究(Analysis of Risk Factors for Postoperative Progressive Segment Degeneration at the Decompression and Non-decompression Segments after Minimally Invasive Lumbar Decompression Surgery: A 5-year Follow-up Study)

Habibi Hasibullah, Toyoda Hiromitsu, Terai Hidetomi, Yamada Kentaro, Kato Minori, Suzuki Akinobu, Takahashi Shinji, Tamai Koji, Iwamae Masayoshi, Sawada Yuta, Kobayashi Yuto, Okamura Yuki, Nakamura Hiroaki

Spine Surgery and Related Research 9 ( 1 ) 22 - 29 2025.01

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除圧手術を受けた腰部脊柱管狭窄症/脊椎すべり症・側彎症患者における術後進行性区域変性症(PSD)発症のリスク因子について、特に除圧セグメントと非除圧セグメントに焦点をあてて検討した。腰部脊柱管狭窄症患者168例の840セグメント(L1-L2、L5-S1)を対象に5年以上の経過観察を行い、X線学的に3mm超の前方すべり、後方すべりまたは椎間板高の3mm超の減少が生じていればPSDと判定を下した。PSDの発症を162セグメント(19.3%)に認め、発症率は除圧セグメントが46.9%、非除圧セグメントが23.5%と除圧セグメントの方が有意に高かった。PSD発症の独立リスク因子として、非除圧セグメントではCobb角10°以上、3mm以上の脊椎すべり症、L3/4、L4/5、L5/Sが示され、除圧セグメントでは3mm以上の側方すべりが抽出された。5年間においてPSDの発症を認めたのは168例のうち106例(63.1%)であり、PSD発症群の方が非発症群より脚部痛、脚部のしびれ、腰痛を示すVASスコアは不良であった。既存の椎間板変性によって術後PSDの発症リスクが高まる可能性が示された。
Risk factors for adjacent segment disease after lateral lumbar interbody fusion for lumbar spinal canal stenosis with instability

Sawada Y.

European Spine Journal 35 ( 5 ) 2409 - 2416 2025（ ISSN:09406719 ）

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DOI： 10.1007/s00586-025-09708-w

PubMed
Cement leakage risk reduction and propensity score matching analysis of clinical efficacy for Cement-Augmented fenestrated pedicle screw in patients with osteoporosis

Uematsu M.

European Spine Journal 35 ( 4 ) 2187 - 2194 2025（ ISSN:09406719 ）

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DOI： 10.1007/s00586-025-09314-w

PubMed
Disc Level–Specific outcomes of intradiscal condoliase injection for lumbar disc herniation: A multicenter retrospective study

Watanabe K.

Journal of Orthopaedic Science 31 ( 3 ) 521 - 529 2025（ ISSN:09492658 ）

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DOI： 10.1016/j.jos.2025.11.007

PubMed
Predicting Postoperative Neurological Outcomes in Metastatic Spinal Tumor Surgery Using Machine Learning

Maki S.

Spine 51 ( 2 ) 100 - 106 2025（ ISSN:03622436 ）

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DOI： 10.1097/BRS.0000000000005322

PubMed
Does cessation of combustible cigarette and heated tobacco product smoking immediately following a fracture benefit fracture healing? In vivo and in vitro validation

Iwamae M.

Biochemical and Biophysical Research Communications 736 150512 2024.12（ ISSN:0006291X ）

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DOI： 10.1016/j.bbrc.2024.150512

PubMed
Is orthotic treatment beneficial for fresh osteoporotic vertebral fractures? A propensity score matching study.

Masayoshi Iwamae, Shinji Takahashi, Hidetomi Terai, Koji Tamai, Masatoshi Hoshino, Yuto Kobayashi, Masayuki Umano, Ryo Sasaki, Masato Uematsu, Hiroshi Katsuda, Nagakazu Shimada, Hiroaki Nakamura

The spine journal : official journal of the North American Spine Society 24 ( 12 ) 2343 - 2355 2024.12（ ISSN:15299430 ）

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Publishing type：Research paper (scientific journal) International / domestic magazine：International journal

BACKGROUND CONTEXT: Orthotic treatment is a common option for the conservative treatment of osteoporotic vertebral fractures (OVF). However, there is insufficient evidence of its clinical benefit. PURPOSE: To investigate the effectiveness of orthotic treatment for OVF. STUDY DESIGN/SETTING: Retrospective cohort study with data from two prospective studies. PATIENT SAMPLE: This study included 160 patients with fresh OVF enrolled in 2012 and 2020 prospective cohort studies. OUTCOME MEASURES: The visual analog scale (VAS) score for low back pain was used for clinical outcomes, and radiographic parameters included the percent height of the vertebra and angular change of the vertebral body. Moreover, the occurrence of secondary vertebral fractures was followed-up over time. METHODS: The patients were divided into brace and no-brace groups and were matched according to propensity score for age, sex, anterior percent height at the initial examination, and presence of old OVFs. Hazard ratio for the cumulative incidence of secondary vertebral fractures with and without bracing were calculated and analyzed using the generalized Wilcoxon test. In addition, the brace group was divided into soft and rigid brace groups and compared with the no-brace group. RESULTS: Each group had 61 cases after propensity score matching. There were no significant differences in the VAS improvement for low back pain and the change in percent height of the anterior and posterior walls from initial examination to 6 months after injury (p=.87, p=.39 and p=.14, respectively, mixed-effect models). Meanwhile, the mean angular change of fractured vertebrae was 4.3° / 3.2° initially and 1.2° / 2.5° at 6 months (the brace group / no-brace group, respectively; p=.007, mixed-effect models). A significant difference was also observed between the rigid brace group and the no-brace group (p=.008, mixed effect models). The incidence of secondary vertebral fractures was 1.6% / 11.4% at 1 month, indicating a significant difference (the brace group / no-brace group, respectively; p=.028). The hazard ratio for the cumulative incidence of secondary fractures due to orthotic treatment was 0.47 (95% confidence interval 0.20-1.09, p=.054). CONCLUSIONS: Although orthotic treatment for fresh OVF did not relieve pain, it might contribute to the stabilization of the fractured vertebra, especially using a rigid brace. Moreover, it might influence a reduction of the imminent vertebral fracture risk immediately after the onset of OVF. CLASSIFICATIONS: Clinical study.

DOI： 10.1016/j.spinee.2024.08.002

PubMed
Impact of malnutrition on mortality and neurological recovery of older patients with spinal cord injury

Tamai K.

Scientific Reports 14 ( 1 ) 5853 2024.12

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DOI： 10.1038/s41598-024-56527-y

PubMed
Is Intraoperative Blood Loss Volume in Elderly Cervical Spine Injury Surgery Greater in Patients with Ankylosis? A Multicenter Survey

Uehara Masashi, Ikegami Shota, Takizawa Takashi, Oba Hiroki, Yokogawa Noriaki, Sasagawa Takeshi, Nakashima Hiroaki, Segi Naoki, Ito Sadayuki, Funayama Toru, Eto Fumihiko, Yamaji Akihiro, Watanabe Kota, Nori Satoshi, Takeda Kazuki, Furuya Takeo, Yunde Atsushi, Nakajima Hideaki, Yamada Tomohiro, Hasegawa Tomohiko, Terashima Yoshinori, Hirota Ryosuke, Suzuki Hidenori, Imajo Yasuaki, Tonomura Hitoshi, Sakata Munehiro, Hashimoto Ko, Onoda Yoshito, Kawaguchi Kenichi, Haruta Yohei, Suzuki Nobuyuki, Kato Kenji, Uei Hiroshi, Sawada Hirokatsu, Nakanishi Kazuo, Misaki Kosuke, Terai Hidetomi, Tamai Koji, Kuroda Akiyoshi, Inoue Gen, Kakutani Kenichiro, Kakiuchi Yuji, Kiyasu Katsuhito, Tominaga Hiroyuki, Tokumoto Hiroto, Iizuka Yoichi, Takasawa Eiji, Akeda Koji, Takegami Norihiko, Funao Haruki, Oshima Yasushi, Kaito Takashi, Sakai Daisuke, Yoshii Toshitaka, Ohba Tetsuro, Otsuki Bungo, Seki Shoji, Miyazaki Masashi, Ishihara Masayuki, Okada Seiji, Imagama Shiro, Kato Satoshi

Spine Surgery and Related Research 8 ( 6 ) 575 - 582 2024.11（ eISSN:2432261X ）

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Introduction: Preoperative estimations of blood loss are important when planning surgery for cervical spine injuries in older adults. The association between ankylosis and blood loss in perioperative management is of particular interest. This multicenter database review aimed to evaluate the impact of ankylosis on surgical blood loss volume in elderly patients with cervical spine injury.Methods: The case histories of 1512 patients with cervical spine injury at among 33 institutions were reviewed. After the exclusion of patients without surgery or whose blood loss or ankylosis status was unclear, 793 participants were available for analysis. Differences in blood loss volume were compared between the Ankylosis (+) group with ankylosis at the cervical level and the Ankylosis (−) group without by the inverse probability of treatment weighting (IPTW) method using a propensity score.Results: Of the 779 patients (mean age: 75.0±6.3 years) eligible for IPTW calculation, 257 (32.4%) had ankylosis at the cervical level. The mean blood loss volume was higher in Ankylosis (+) patients than in Ankylosis (−) patients (P<0.001). This difference did not reach statistical significance when weighted by background factors, with mean blood loss of 244 mL and 188 mL, respectively, after adjustment.Conclusions: This study revealed that ankylosis was significantly associated with increased blood loss volume when unadjusted by surgical time. Elderly patients with cervical spine injury accompanied by ankylosis appear predisposed to higher bleeding and severe hemorrhage, both as a result of the condition and their particular demographic characteristics.

DOI： 10.22603/ssrr.2023-0118

PubMed

CiNii Research
Stroke in critically ill patients with respiratory failure due to COVID-19: Disparities between low-middle and high-income countries

Battaglini D.

Heart and Lung 68 131 - 144 2024.11（ ISSN:01479563 ）

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DOI： 10.1016/j.hrtlng.2024.06.015
脊椎強直を呈する高齢患者における頸椎損傷手術によって出血量は増大するのか　多施設共同調査(Is Intraoperative Blood Loss Volume in Elderly Cervical Spine Injury Surgery Greater in Patients with Ankylosis?: A Multicenter Survey)

Uehara Masashi, Ikegami Shota, Takizawa Takashi, Oba Hiroki, Yokogawa Noriaki, Sasagawa Takeshi, Nakashima Hiroaki, Segi Naoki, Ito Sadayuki, Funayama Toru, Eto Fumihiko, Yamaji Akihiro, Watanabe Kota, Nori Satoshi, Takeda Kazuki, Furuya Takeo, Yunde Atsushi, Nakajima Hideaki, Yamada Tomohiro, Hasegawa Tomohiko, Terashima Yoshinori, Hirota Ryosuke, Suzuki Hidenori, Imajo Yasuaki, Tonomura Hitoshi, Sakata Munehiro, Hashimoto Ko, Onoda Yoshito, Kawaguchi Kenichi, Haruta Yohei, Suzuki Nobuyuki, Kato Kenji, Uei Hiroshi, Sawada Hirokatsu, Nakanishi Kazuo, Misaki Kosuke, Terai Hidetomi, Tamai Koji, Kuroda Akiyoshi, Inoue Gen, Kakutani Kenichiro, Kakiuchi Yuji, Kiyasu Katsuhito, Tominaga Hiroyuki, Tokumoto Hiroto, Iizuka Yoichi, Takasawa Eiji, Akeda Koji, Takegami Norihiko, Funao Haruki, Oshima Yasushi, Kaito Takashi, Sakai Daisuke, Yoshii Toshitaka, Ohba Tetsuro, Otsuki Bungo, Seki Shoji, Miyazaki Masashi, Ishihara Masayuki, Okada Seiji, Imagama Shiro, Kato Satoshi

Spine Surgery and Related Research 8 ( 6 ) 575 - 582 2024.11

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高齢頸椎損傷患者において脊椎強直が術中出血量に影響を及ぼすかどうか検討した。頸椎損傷に対して手術を施行された高齢患者779例を対象に多施設共同調査を行い、逆確率重み付け(IPTW)法を用いて脊椎強直群257例(男性208例、女性49例、平均75.2±6.3歳)と非強直群522例(男性326例、女性196例、平均74.9±6.3歳)の術中出血量を比較した。平均手術時間は脊椎強直群が177分、非強直群が159分、平均出血量は強直群が279mL、非強直群が171mLであり、出血量は強直群の方が有意に多かったが、背景因子の重み付けを行うと強直群244mL、非強直群188mLとなり有意差はみられなかった。手術時間は強直群の方が非強直群より長く、この結果に基づいてIPTW法を実施した。その結果、平均出血量は強直群が333mL、非強直群が170mLと強直群の方が有意に高値を示していた。1000mL以上の出血がみられた患者も強直群に有意に多かった。頸椎損傷に対して手術を施行された高齢患者では、脊椎強直が術中出血量高値と有意に関連することが明らかになった。
Minimum Clinically Important Difference of the Japanese Orthopaedic Association Back Pain Evaluation Questionnaire for Patients with Lumbar Spine Disease Undergoing Posterior Surgery by Generation

Kato Minori, Terai Hidetomi, Namikawa Takashi, Matsumura Akira, Hoshino Masatoshi, Toyoda Hiromitsu, Suzuki Akinobu, Takahashi Shinji, Tamai Koji, Sawada Yuta, Iwamae Masayoshi, Okamura Yuki, Kobayashi Yuto, Nakamura Hiroaki

Spine Surgery and Related Research 8 ( 5 ) 518 - 527 2024.09（ eISSN:2432261X ）

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Publishing type：Research paper (scientific journal) International / domestic magazine：Domestic journal

Introduction: Few studies have assessed the minimum clinically important difference (MCID) of each Japanese Orthopaedic Association Back Pain Evaluation Questionnaire (JOABPEQ) domain. This study assessed MCIDs of JOABPEQ in patients with lumbar spine disease by generation.Methods: We evaluated the JOABPEQ score of 805 consecutive patients with lumbar spine disease undergoing posterior surgery preoperatively and 1 year postoperatively. MCIDs of each JOABPEQ domain were determined using anchor- and distribution-based methods according to age. A question based on the concept of a health transition item was used as the anchor for the MCID decision.Results: Overall, MCIDs of the JOABPEQ were 28.6 and 27.3 points for pain-related disorder and gait disturbance, respectively. The MCID for the lumbar spine dysfunction domain did not reach 0.6 over the area under the curve. Regarding the differences among generations, MCIDs of pain-related disorder and gait disturbance domains differed slightly between the elderly and middle-aged. The psychological disorder domain did not reflect clinically meaningful changes in the elderly. MCIDs of the social life disturbance domain decreased with age.Conclusions: Focusing on achieving the ideal responsiveness of patient-reported outcomes across generations, MCIDs of the pain-related disorder and gait disturbance domains may be valuable for patients, regardless of age, when adopting the JOABPEQ for patients with lumbar spine disease undergoing surgery. This study only evaluated cases that underwent posterior lumbar surgery. Future research will necessitate conducting surveys concerning the outcomes of various treatments for lumbar spine disease.

DOI： 10.22603/ssrr.2023-0293

PubMed

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Low Nutrition before Injury Is a Risk Factor for Dysphagia in Older Patients with Cervical Spinal Cord Injury: Based on a Multicenter Data of 707 Patients

Segi Naoki, Nakashima Hiroaki, Ito Sadayuki, Ouchida Jun, Yokogawa Noriaki, Sasagawa Takeshi, Funayama Toru, Eto Fumihiko, Watanabe Kota, Nori Satoshi, Furuya Takeo, Yunde Atsushi, Terashima Yoshinori, Hirota Ryosuke, Nakajima Hideaki, Yamada Tomohiro, Hasegawa Tomohiko, Kawaguchi Kenichi, Haruta Yohei, Hashimoto Ko, Onoda Yoshito, Nakanishi Kazuo, Misaki Kosuke, Ikegami Shota, Uehara Masashi, Suzuki Hidenori, Imajo Yasuaki, Uei Hiroshi, Sawada Hirokatsu, Terai Hidetomi, Tamai Koji, Kuroda Akiyoshi, Inoue Gen, Suzuki Nobuyuki, Kato Kenji, Akeda Koji, Takegami Norihiko, Iizuka Yoichi, Oshima Yasushi, Tonomura Hitoshi, Kiyasu Katsuhito, Funao Haruki, Yoshii Toshitaka, Ishihara Masayuki, Kaito Takashi, Seki Shoji, Kakutani Kenichiro, Tominaga Hiroyuki, Ohba Tetsuro, Sakai Daisuke, Otsuki Bungo, Miyazaki Masashi, Okada Seiji, Imagama Shiro, Kato Satoshi

Spine Surgery and Related Research 8 ( 5 ) 473 - 479 2024.09（ eISSN:2432261X ）

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Introduction: For older adults, dysphagia is a serious problem that can occur after spinal cord injury (SCI), but its risk factors are unclear. This study aimed to identify risk factors for dysphagia in elderly patients (≥65 years) with cervical SCI.Methods: This multicenter study included 707 patients with cervical SCI (mean age 75.3 years). Univariate and multivariate analyses were conducted for patient characteristics and geriatric nutritional risk index (GNRI).Results: Dysphagia occurred in 69 patients (9.8%). The significant factors were as follows: male sex (odds ratio [OR] 3.43), GNRI <92 (1.83), dementia (2.94), fracture (3.40), complete paralysis (3.61), anterior surgery (3.74), and tracheostomy (17.06). Age was not identified as a risk factor.Conclusions: Low GNRI before injury was one of the independent risk factors for dysphagia after geriatric cervical SCI. GNRI represents the comprehensive nutritional status of the elderly and reflects feeding function and its recovery capacity.

DOI： 10.22603/ssrr.2023-0227

PubMed

CiNii Research
腰椎疾患患者の年代別にみた日本整形外科学会背部痛評価質問票の最小臨床重要変化量(Minimum Clinically Important Difference of the Japanese Orthopaedic Association Back Pain Evaluation Questionnaire for Patients with Lumbar Spine Disease Undergoing Posterior Surgery by Generation)

Kato Minori, Terai Hidetomi, Namikawa Takashi, Matsumura Akira, Hoshino Masatoshi, Toyoda Hiromitsu, Suzuki Akinobu, Takahashi Shinji, Tamai Koji, Sawada Yuta, Iwamae Masayoshi, Okamura Yuki, Kobayashi Yuto, Nakamura Hiroaki

Spine Surgery and Related Research 8 ( 5 ) 518 - 527 2024.09

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腰椎疾患患者における日本整形外科学会背部痛評価質問票(JOABPEQ)の最小臨床重要変化量(MCID)を年代別に検討した。後方アプローチにて手術を施行された腰椎疾患患者805例を対象に、術前と術後1年にJOABPEQを測定し、アンカーベース法と分布ベース法を用いて各JOABPEQドメインのMCIDを算出した。被験者は65歳未満の中年群226例(男性112例、女性114例、平均55.8±8.8歳)、65～74歳の前期高齢者群316例(男性151例、女性165例、平均70.1±2.9歳)、75歳以上の後期高齢者群263例(男性108例、女性155例、平均79.5±2.8歳)に分類した。ASA IIIは後期高齢者群に有意に多くみられ、JOAスコアは術前の12.5点から術後1年目に22.5点に増加し、改善率は60.7%、腰痛VASスコアの減少度は24.0mm、脚部痛VASスコアの減少度は40.3mmを示していた。JOABPEQの各ドメイン(疼痛関連障害、歩行障害、社会生活障害)は術後に20点超を示し、年代別の比較では後期高齢者群のスコアは中年群より有意に低かった。アンカーベース法の結果をみると、改善と判定された患者数は中年群が156例、前期高齢者群が186例、後期高齢者群が124例であり、年齢を重ねるのに伴って改善率は低くなっていた。疼痛関連障害と歩行障害のMCIDにみられる中年群と高齢者群との差は軽微なものであり、心理的障害ドメインに群間差はなく、社会生活障害のMCIDは加齢に伴って減少していた。
頸髄損傷高齢患者の嚥下障害のリスク因子としての損傷前低栄養　707例の多施設データ(Low Nutrition before Injury Is a Risk Factor for Dysphagia in Older Patients with Cervical Spinal Cord Injury: Based on a Multicenter Data of 707 Patients)

Segi Naoki, Nakashima Hiroaki, Ito Sadayuki, Ouchida Jun, Yokogawa Noriaki, Sasagawa Takeshi, Funayama Toru, Eto Fumihiko, Watanabe Kota, Nori Satoshi, Furuya Takeo, Yunde Atsushi, Terashima Yoshinori, Hirota Ryosuke, Nakajima Hideaki, Yamada Tomohiro, Hasegawa Tomohiko, Kawaguchi Kenichi, Haruta Yohei, Hashimoto Ko, Onoda Yoshito, Nakanishi Kazuo, Misaki Kosuke, Ikegami Shota, Uehara Masashi, Suzuki Hidenori, Imajo Yasuaki, Uei Hiroshi, Sawada Hirokatsu, Terai Hidetomi, Tamai Koji, Kuroda Akiyoshi, Inoue Gen, Suzuki Nobuyuki, Kato Kenji, Akeda Koji, Takegami Norihiko, Iizuka Yoichi, Oshima Yasushi, Tonomura Hitoshi, Kiyasu Katsuhito, Funao Haruki, Yoshii Toshitaka, Ishihara Masayuki, Kaito Takashi, Seki Shoji, Kakutani Kenichiro, Tominaga Hiroyuki, Ohba Tetsuro, Sakai Daisuke, Otsuki Bungo, Miyazaki Masashi, Okada Seiji, Imagama Shiro, Kato Satoshi

Spine Surgery and Related Research 8 ( 5 ) 473 - 479 2024.09

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頸髄損傷を呈した高齢患者における嚥下障害発症のリスク因子について検討した。65歳以上の頸髄損傷患者707例(男性511例、女性196例、平均75.3±6.7歳)を対象に多施設研究を行った。高齢者栄養評価指標(GNRI)は平均96.9、5項目修正フレイル指標(mFI-5)が2点以下を示していたのが約80%、頸部骨折を38%に認め、米国脊椎損傷学会障害度指数(AIS)Dを伴う麻痺が35%に検出された。被験者のうち66%に手術を施行し、後方アプローチが大半を占めていた。嚥下障害の発症を69例(9.8%)に認め、単変量解析では男性、GNRI 92未満、喫煙、後縦靱帯骨化、骨折、完全麻痺(AIS AまたはB)、手術治療、前方アプローチ、および気管切開が嚥下障害の発症に関わる有意なリスク因子として示された。ロジスティック回帰分析では男性、GNRI 92未満、認知症、骨折、完全麻痺、前方アプローチおよび気管切開が嚥下障害の有意なリスク因子として抽出された。頸髄受傷前のGNRI低値が嚥下障害発症のリスク因子のひとつであることが明らかになった。
Effects of Orthotic Treatment on Fresh Osteoporotic Vertebral Fractures

Iwamae Masayoshi, Takahashi Shinji, Terai Hidetomi, Tamai Koji, Hoshino Masatoshi, Toyoda Hiromitsu, Suzuki Akinobu, Kato Minori, Umano Masayuki, Kobayashi Yuto, Sasaki Ryo, Uematsu Masato, Shimada Nagakazu, Nakamura Hiroaki

Journal of Spine Research 15 ( 6 ) 869 - 876 2024.06（ ISSN:18847137 ）（ eISSN:24351563 ）

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Osteoporotic vertebral fractures (OVF) are the most common osteoporotic fractures, affecting patients' quality of life and activity of daily life. Although orthotics is generally the treatment of choice for conservative treatment of OVF, the current evidence for orthotics is limited. Prospective studies without orthotics for the conservative treatment of OVF are difficult due to an ethical point of view because it is common sense that orthotics are the treatment of choice. In fact, there are very few reports that have verified the effectiveness of orthotics compared to no orthotics in the past. Therefore, we compared data from a cohort without orthotics and a cohort with orthotics using propensity score matching to demonstrate the effect of orthotics. In this review, we summarize the effects of orthotics in OVF based on reports of orthotics, including our previous study.

DOI： 10.34371/jspineres.2024-0610

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Epidemiology of Cervical Fracture/Cervical Spinal Cord Injury and Changes in Surgical Treatment Modalities in Elderly Individuals During a 10-year Period: A Nationwide Multicenter Study in Japan

Segi N.

Global Spine Journal 14 ( 5 ) 1583 - 1594 2024.06（ ISSN:21925682 ）

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DOI： 10.1177/21925682231151643

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Risk Factors for Residual Back Pain After Balloon Kyphoplasty for Osteoporotic Vertebral Fracture.

Hamidullah Salimi, Shinji Takahashi, Masatoshi Hoshino, Yusuke Hori, Hiroyuki Yasuda, Tadao Tsujio, Shoichiro Ohyama, Hidetomi Terai, Hiromitsu Toyoda, Akinobu Suzuki, Hiroshi Kono, Sho Dohzono, Koji Tamai, Hiroaki Nakamura

Indian journal of orthopaedics 58 ( 5 ) 567 - 574 2024.05（ ISSN:00195413 ）

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Publishing type：Research paper (scientific journal) International / domestic magazine：International journal

BACKGROUND: Balloon kyphoplasty (BKP) is a method for the management of osteoporotic vertebral body fracture (OVF). However, improvement in back pain (BP) is poor in some patients, also previous reports have not elucidated the exact incidence and risk factors for residual BP after BKP. We clarified the characteristics of residual BP after BKP in patients with OVF. HYPOTHESIS: In this study, we hypothesize that some risk factors may exist for residual BP 2 years after the treatment of OVF with BKP. PATIENTS AND METHODS: A multicenter cohort study was performed where patients who received BKP within 2 months of OVF injury were followed-up for 2 years. BP at 6 months after surgery and final observation was evaluated by Visual Analog Scale (VAS) score. Patients with a score of 40 mm or more were allocated to the residual BP group, and comparisons between the residual back pain group and the improved group were made for bone density, kyphosis, mobility of the fractured vertebral body, total spinal column alignment, and fracture type (fracture of the posterior element, pedicle fracture, presence or absence of posterior wall damage, etc.). Also, Short Form 36 (SF-36) for physical component summary (PCS) and mental component summary (MCS) at the final follow-up was evaluated in each radiological finding. RESULTS: Of 116 cases, 79 (68%) were followed-up for 2 years. Two years after the BKP, 26 patients (33%) experienced residual BP. Neither age nor sex differed between the groups. In addition, there was no difference in bone mineral density, BKP intervention period (period from onset to BKP), and osteoporosis drug use. However, the preoperative height ratio of the vertebral body was significantly worse in the residual BP group (39.8% vs. 52.1%; p = 0.007). Two years after the operation, the vertebral body wedge angle was significantly greater in the residual BP group (15.7° vs. 11.9°; p = 0.042). In the multiple logistic regression model with a preoperative vertebral body height ratio of 50% or less [calculated by receiver operating characteristic (ROC) curve], the adjusted odds ratio for residual BP was 6.58 (95% confidence interval 1.64-26.30; p = 0.007); similarly, patients with vertebral body height ratio less than 50% had a lower score of SF-36 PCS 24.6 vs. 32.2 p = 0.08. CONCLUSION: The incidence of residual BP 2 years after BKP was 33% in the current study. The risk factor for residual BP after BKP was a preoperative vertebral body height ratio of 50% or less, which should be attentively assessed for the selection of a proper treatment scheme and to provide adequate stabilization. LEVEL OF EVIDENCE: III.

DOI： 10.1007/s43465-024-01115-5

PubMed
Neurological recovery rate and predictive factors of incomplete AIS grade C spinal cord injury in the older aged population

Tamai K.

Spinal Cord 62 ( 4 ) 149 - 155 2024.04（ ISSN:13624393 ）

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DOI： 10.1038/s41393-024-00963-0

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Residual Paresthesia After Surgery for Degenerative Cervical Myelopathy: Incidence and Impact on Clinical Outcomes and Satisfaction

Tamai K.

Spine 49 ( 6 ) 378 - 384 2024.03（ ISSN:03622436 ）

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DOI： 10.1097/BRS.0000000000004907

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Influence of the timing of surgery for cervical spinal cord injury without bone injury in the elderly: A retrospective multicenter study

Nori S.

Journal of Orthopaedic Science 29 ( 2 ) 480 - 485 2024.03（ ISSN:09492658 ）

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DOI： 10.1016/j.jos.2023.01.004

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高齢者の骨損傷を伴わない頸髄損傷に対して手術のタイミングが及ぼす影響　後ろ向き多施設共同研究(Influence of the timing of surgery for cervical spinal cord injury without bone injury in the elderly: A retrospective multicenter study)

Nori Satoshi, Watanabe Kota, Takeda Kazuki, Yamane Junichi, Kono Hitoshi, Yokogawa Noriaki, Sasagawa Takeshi, Ando Kei, Nakashima Hiroaki, Segi Naoki, Funayama Toru, Eto Fumihiko, Yamaji Akihiro, Furuya Takeo, Yunde Atsushi, Nakajima Hideaki, Yamada Tomohiro, Hasegawa Tomohiko, Terashima Yoshinori, Hirota Ryosuke, Suzuki Hidenori, Imajo Yasuaki, Ikegami Shota, Uehara Masashi, Tonomura Hitoshi, Sakata Munehiro, Hashimoto Ko, Onoda Yoshito, Kawaguchi Kenichi, Haruta Yohei, Uei Hiroshi, Sawada Hirokatsu, Nakanishi Kazuo, Misaki Kosuke, Terai Hidetomi, Tamai Koji, Shirasawa Eiki, Inoue Gen, Kiyasu Katsuhito, Iizuka Yoichi, Takasawa Eiji, Funao Haruki, Kaito Takashi, Yoshii Toshitaka, Ishihara Masayuki, Okada Seiji, Imagama Shiro, Kato Satoshi

Journal of Orthopaedic Science 29 ( 2 ) 480 - 485 2024.03（ ISSN:0949-2658 ）

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高齢者の骨損傷を伴わない頸髄損傷(CSCI)に対する受傷48時間以内の手術施行が神経学的回復に及ぼす影響を検討した。2010～2020年に手術を受けた65歳以上のCSCI患者159例を対象に多施設共同後ろ向き研究を行い、受傷48時間以内の早期手術施行群24例(男性62.5%、平均73.5±6.12歳)と48時間以降の後期手術施行群135例(男性73.3%、平均74.1±6.02歳)に分類した。全例のうち97.5%に後方アプローチが採用されており、術式、手術時間、出血量のほか、硬膜断裂、手術部位感染症、C5麻痺、神経学的増悪、心筋梗塞、脳梗塞、せん妄、嚥下障害、呼吸不全、肺塞栓症などの合併症の発症に関して早期手術群と後期手術群との間に有意差はみられなかった。受傷後6ヵ月におけるAmerican Spinal Injury Association Motor Score(AMS)は後期手術群の方が早期手術群より有意に高値を示していたが、ベースライン時から6ヵ月後までのAMSの変化は早期手術群の方が有意に大きかった。線形重回帰分析では、ベースライン時のAMS、せん妄、肺炎、糖尿病が術後のAMSの変化に有意な負の影響を及ぼすことが判明し、早期手術施行とAMSの変化との間に有意な関連は認められなかった。
Degeneration of Cervical Multifidus Muscles Negatively Affects Physical Activity-related Quality of Life After Laminoplasty for Degenerative Cervical Myelopathy.

Masayoshi Iwamae, Koji Tamai, Akinobu Suzuki, Hidetomi Terai, Masatoshi Hoshino, Minori Kato, Hiromitsu Toyoda, Shinji Takahashi, Akito Yabu, Yuta Sawada, Hiroaki Nakamura

Clinical spine surgery 37 ( 8 ) E364 - E370 2024.02（ ISSN:23800186 ）

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Publishing type：Research paper (scientific journal) International / domestic magazine：International journal

STUDY DESIGN: A retrospective cohort study. OBJECTIVE: The study aimed to investigate the related factors affecting physical activity-related quality of life (QOL) after 2 years of cervical laminoplasty for degenerative cervical myelopathy (DCM), focusing on the degree of preoperative degeneration of the cervical multifidus muscles. SUMMARY OF BACKGROUND DATA: The association between paraspinal muscle degeneration and clinical outcomes after spinal surgery is being investigated. The effect of preoperative degeneration of the cervical multifidus muscles in patients undergoing cervical laminoplasty is ambiguous. METHODS: Patients who underwent laminoplasty for DCM and followed up for more than 2 years were reviewed. To evaluate physical QOL, the physical component summary (PCS) of the 36-Item Short-Form Health Survey (SF-36) was recorded at 2 years postoperatively. The degree of preoperative degeneration in the multifidus muscles at the C4 and C7 levels on axial T2-weighted magnetic resonance imaging (MRI) was categorized according to the Goutallier grading system. The correlation between 2-year postoperative PCS and each preoperative clinical outcome, radiographic parameter, and MRI finding, including Goutallier classification, was analyzed. Variables with a P value <0.10 in univariate analysis were included in multiple linear regression analysis. RESULTS: In total, 106 consecutive patients were included. The 2-year postoperative PCS demonstrated significant correlation with age (R=-0.358, P=0.002), preoperative JOA score (R=0.286, P=0.021), preoperative PCS (R=0.603, P<0.001), C2-C7 lordotic angle (R=-0.284, P=0.017), stenosis severity (R=-0.271, P=0.019), and Goutallier classification at the C7 level (R=-0.268, P=0.021). In multiple linear regression analysis, sex (β=-0.334, P=0.002), age (β=-0.299, P=0.013), preoperative PCS (β=0.356, P=0.009), and Goutallier classification at the C7 level (β=-0.280, P=0.018) were significantly related to 2-year postoperative PCS. CONCLUSIONS: Increased degeneration of the multifidus muscle at the C7 level negatively affected physical activity-related QOL postoperatively. These results may guide spine surgeons in predicting physical activity-related QOL in patients with DCM after laminoplasty. LEVEL OF EVIDENCE: Level III.

DOI： 10.1097/BSD.0000000000001585

PubMed
連載最新原著レビュー新型コロナウイルス感染症パンデミックが脊椎疾患を有する高齢者に与えた影響

寺井秀富, 高橋真治, 玉井孝司, 中村博亮

整形外科 75 ( 2 ) 165 - 167 2024.02（ ISSN:00305901 ）（ eISSN:24329444 ）

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DOI： 10.15106/j_seikei75_165

CiNii Research
Prognostic Factors for Respiratory Dysfunction for Cervical Spinal Cord Injury and/or Cervical Fractures in Elderly Patients: A Multicenter Survey.

Hirota R, Terashima Y, Ohnishi H, Yamashita T, Yokogawa N, Sasagawa T, Ando K, Nakashima H, Segi N, Funayama T, Eto F, Yamaji A, Watanabe K, Yamane J, Takeda K, Furuya T, Yunde A, Nakajima H, Yamada T, Hasegawa T, Suzuki H, Imajo Y, Ikegami S, Uehara M, Tonomura H, Sakata M, Hashimoto K, Onoda Y, Kawaguchi K, Haruta Y, Suzuki N, Kato K, Uei H, Sawada H, Nakanishi K, Misaki K, Terai H, Tamai K, Shirasawa E, Inoue G, Kakutani K, Kakiuchi Y, Kiyasu K, Tominaga H, Tokumoto H, Iizuka Y, Takasawa E, Akeda K, Takegami N, Funao H, Oshima Y, Kaito T, Sakai D, Yoshii T, Ohba T, Otsuki B, Seki S, Miyazaki M, Ishihara M, Okada S, Imagama S, Kato S

Global spine journal 14 ( 1 ) 101 - 112 2024.01（ ISSN:2192-5682 ）

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DOI： 10.1177/21925682221095470

PubMed
Short-Term Risk Factors for Distal Junctional Kyphosis after Spinal Reconstruction Surgery in Patients with Osteoporotic Vertebrae

Sawada Y.

Asian Spine Journal 18 ( 1 ) 101 - 109 2024（ ISSN:19761902 ）

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DOI： 10.31616/asj.2023.0174

PubMed
Machine-learning-based approach for nonunion prediction following osteoporotic vertebral fractures.

Takahashi S, Terai H, Hoshino M, Tsujio T, Kato M, Toyoda H, Suzuki A, Tamai K, Yabu A, Nakamura H

European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society 32 ( 11 ) 3788 - 3796 2023.11（ ISSN:0940-6719 ）

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DOI： 10.1007/s00586-022-07431-4

PubMed
The Impact of Multidisciplinary Approaches to Social Functioning on Surgical Outcomes After Surgery for Cervical Myelopathy.

Tamai K, Terai H, Watanabe S, Tashiro Y, Omine T, Katsuda H, Shimada N, Kobayashi Y, Nakamura H

Spine 48 ( 19 ) 1365 - 1372 2023.10（ ISSN:0362-2436 ）

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DOI： 10.1097/BRS.0000000000004764

PubMed
Prognostic impact of respiratory dysfunction in elderly patients with cervical spinal cord injury and/or fractures: a multicenter survey.

Hirota R, Terashima Y, Ohnishi H, Yamashita T, Yokogawa N, Sasagawa T, Nakashima H, Segi N, Ito S, Funayama T, Eto F, Yamaji A, Watanabe K, Nori S, Takeda K, Furuya T, Yunde A, Nakajima H, Yamada T, Hasegawa T, Suzuki H, Imajo Y, Ikegami S, Uehara M, Tonomura H, Sakata M, Hashimoto K, Onoda Y, Kawaguchi K, Haruta Y, Suzuki N, Kato K, Uei H, Sawada H, Nakanishi K, Misaki K, Terai H, Tamai K, Kuroda A, Inoue G, Kakutani K, Kakiuchi Y, Kiyasu K, Tominaga H, Tokumoto H, Iizuka Y, Takasawa E, Akeda K, Takegami N, Funao H, Oshima Y, Kaito T, Sakai D, Yoshii T, Ohba T, Otsuki B, Seki S, Miyazaki M, Ishihara M, Okada S, Imagama S, Kato S

European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society 32 ( 10 ) 3522 - 3532 2023.10（ ISSN:0940-6719 ）

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DOI： 10.1007/s00586-023-07828-9

PubMed
Risk of Revision After Vertebral Augmentation for Osteoporotic Vertebral Fracture: A Narrative Review.

Takahashi S, Inose H, Tamai K, Iwamae M, Terai H, Nakamura H

Neurospine 20 ( 3 ) 852 - 862 2023.09（ ISSN:2586-6583 ）

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DOI： 10.14245/ns.2346560.280

PubMed
Development of locomotive syndrome in elderly population after COVID-19 outbreak: A population-based cross-sectional study with over 12,000 participants.

Terai H, Tamai K, Takahashi S, Katsuda H, Shimada N, Hori Y, Kobayashi Y, Nakamura H

Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association 28 ( 4 ) 895 - 900 2023.07（ ISSN:0949-2658 ）

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DOI： 10.1016/j.jos.2022.05.012

PubMed
Factors Predicting the Final Diagnosis in Image-Guided Percutaneous Needle Biopsy for Suspected Spinal Tumors.

Oka M, Suzuki A, Terai H, Kato M, Toyoda H, Takahashi S, Tamai K, Nakamura H

Journal of clinical medicine 12 ( 13 ) 2023.06（ ISSN:2077-0383 ）

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DOI： 10.3390/jcm12134292

PubMed
Risk of Residual Low Back Pain in Conservative Treatment of Osteoporotic Vertebral Fractures without Poor Prognostic Factors on Magnetic Resonance Imaging

Iwamae Masayoshi, Terai Hidetomi, Tamai Koji, Hoshino Masatoshi, Takahashi Shinji, Umano Masayuki, Kobayashi Yuto, Katsuda Hiroshi, Kaneda Kunikazu, Shimada Nagakazu, Nakamura Hiroaki

Journal of Spine Research 14 ( 5 ) 786 - 793 2023.05（ ISSN:18847137 ）（ eISSN:24351563 ）

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Introduction: Poor prognostic factors (PPF) on magnetic resonance imaging (MRI) (confined high intensity area or diffuse low intensity area in fractured vertebrae on T2-weighted MR images) predict delayed union after osteoporotic vertebral fractures (OVF). However, although we have treated OVF without PPF on MRI conservatively, there have been a few cases with residual low back pain. Therefore, the objectives of this study were to identify the risk factors of residual low back pain despite the absence of PPF on MRI, and to investigate clinical and radiographical characteristics during follow-up in such patients.Methods: This retrospective cohort study included 55 patients (mean age 75.1 years, 47 females) who were followed up for over 6 months after conservative treatment for OVF. The cases with PPF on MRI or with cauda equina or nerve root compressed on MRI were excluded. The participants were divided into two groups: the residual low back pain group (VAS in low back pain ≥40 at 6 months; 16 patients) and the control group (39 patients). Evaluation items included radiographic parameters on dynamic films (sitting/supine lateral views) and whole spine X-ray, VAS in low back pain/buttock pain at the initial examination and 6 months after injury.Results: Firstly, to identify the risk factors, univariate analysis showed significant differences in VAS in buttock pain at initial examination (p = 0.002), motion angle of fractured vertebrae (p = 0.047), TK (p = 0.046), and LL (p = 0.031). Multivariate analysis showed that VAS in buttock pain at first examination was an independent risk factor for residual low back pain 6 months after injury (adjusted odds ratio = 1.526, p = 0.019). Secondly, the patients in the residual low back pain group were significantly larger SVA at 6 months and more change in the height of anterior wall of fractured vertebrae in dynamic films at 6 months than those in the control group (p = 0.029 and p = 0.011, respectively). Moreover, the cases with confined high intensity area on T2-weighted images at 6 months were significantly more in the residual low back pain group than in the control group (p = 0.006). Conclusions: The risk factor for residual low back pain after conservative treatment for OVF without PPF on MRI was buttock pain at the initial examination. The causes of residual low back pain were a larger SVA and delayed union of the fractured vertebrae. Patients with buttock pain at the initial examination should be carefully followed up, and surgical intervention such as vertebroplasty might be considered as necessary.

DOI： 10.34371/jspineres.2022-0050

CiNii Research
Risk Factors for Poor Outcome after Palliative Surgery for Metastatic Spinal Tumors.

Suzuki A, Terai H, Takahashi S, Kato M, Toyoda H, Tamai K, Hori Y, Okamura Y, Nakamura H

Journal of clinical medicine 12 ( 10 ) 2023.05（ ISSN:2077-0383 ）

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DOI： 10.3390/jcm12103442

PubMed
A case report of pathological fracture of the thoracic spine with a difficulty in diagnosis

SUZUKI Maya

The Central Japan Journal of Orthopaedic Surgery & Traumatology 66 ( 3 ) 507 - 508 2023.05（ ISSN:00089443 ）（ eISSN:13490885 ）

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DOI： 10.11359/chubu.2023.507

CiNii Research
Deep Learning Algorithm for Identifying Cervical Cord Compression Due to Degenerative Canal Stenosis on Radiography.

Tamai K, Terai H, Hoshino M, Tabuchi H, Kato M, Toyoda H, Suzuki A, Takahashi S, Yabu A, Sawada Y, Iwamae M, Oka M, Nakaniwa K, Okada M, Nakamura H

Spine 48 ( 8 ) 519 - 525 2023.04（ ISSN:0362-2436 ）

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DOI： 10.1097/BRS.0000000000004595

PubMed
Neck pain and related factors in patients with rheumatoid arthritis.

Suzuki A, Yamada K, Yabu A, Tamai K, Takahashi S, Inui K, Okano T, Koike T, Nakamura H

Modern rheumatology 33 ( 3 ) 503 - 508 2023.04（ ISSN:1439-7595 ）

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DOI： 10.1093/mr/roac049

PubMed
Delirium Risk Score in Elderly Patients with Cervical Spinal Cord Injury and/or Cervical Fracture.

Tamai K, Terai H, Nakamura H, Yokogawa N, Sasagawa T, Nakashima H, Segi N, Ito S, Funayama T, Eto F, Yamaji A, Watanabe K, Yamane J, Takeda K, Furuya T, Yunde A, Nakajima H, Yamada T, Hasegawa T, Terashima Y, Hirota R, Suzuki H, Imajo Y, Ikegami S, Uehara M, Tonomura H, Sakata M, Hashimoto K, Onoda Y, Kawaguchi K, Haruta Y, Suzuki N, Kato K, Uei H, Sawada H, Nakanishi K, Misaki K, Kuroda A, Inoue G, Kakutani K, Kakiuchi Y, Kiyasu K, Tominaga H, Tokumoto H, Iizuka Y, Takasawa E, Akeda K, Takegami N, Funao H, Oshima Y, Kaito T, Sakai D, Yoshii T, Ohba T, Otsuki B, Seki S, Miyazaki M, Ishihara M, Okada S, Imagama S, Kato S

Journal of clinical medicine 12 ( 6 ) 2023.03（ ISSN:2077-0383 ）

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DOI： 10.3390/jcm12062387

PubMed
Effects of Dementia on Outcomes after Cervical Spine Injuries in Elderly Patients: Evaluation of 1512 Cases in a Nationwide Multicenter Study in Japan.

Yamada Y, Yokogawa N, Kato S, Sasagawa T, Tsuchiya H, Nakashima H, Segi N, Ito S, Funayama T, Eto F, Yamaji A, Yamane J, Nori S, Furuya T, Yunde A, Nakajima H, Yamada T, Hasegawa T, Terashima Y, Hirota R, Suzuki H, Imajo Y, Ikegami S, Uehara M, Tonomura H, Sakata M, Hashimoto K, Onoda Y, Kawaguchi K, Haruta Y, Suzuki N, Kato K, Uei H, Sawada H, Nakanishi K, Misaki K, Terai H, Tamai K, Kuroda A, Inoue G, Kakutani K, Kakiuchi Y, Kiyasu K, Tominaga H, Tokumoto H, Iizuka Y, Takasawa E, Akeda K, Takegami N, Funao H, Oshima Y, Kaito T, Sakai D, Yoshii T, Ohba T, Otsuki B, Seki S, Miyazaki M, Ishihara M, Okada S, Imagama S, Watanabe K

Journal of clinical medicine 12 ( 5 ) 2023.02（ ISSN:2077-0383 ）

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DOI： 10.3390/jcm12051867

PubMed
Characteristics of the cervical spine and cervical cord injuries in older adults with cervical ossification of the posterior longitudinal ligament.

Okuwaki S, Funayama T, Koda M, Eto F, Yamaji A, Yokogawa N, Sasagawa T, Ando K, Nakashima H, Segi N, Watanabe K, Nori S, Takeda K, Furuya T, Yunde A, Nakajima H, Yamada T, Hasegawa T, Terashima Y, Hirota R, Suzuki H, Imajo Y, Ikegami S, Uehara M, Tonomura H, Sakata M, Hashimoto K, Onoda Y, Kawaguchi K, Haruta Y, Suzuki N, Kato K, Uei H, Sawada H, Nakanishi K, Misaki K, Terai H, Tamai K, Shirasawa E, Inoue G, Kakutani K, Kakiuchi Y, Kiyasu K, Tominaga H, Tokumoto H, Iizuka Y, Takasawa E, Akeda K, Takegami N, Funao H, Oshima Y, Kaito T, Sakai D, Yoshii T, Ohba T, Otsuki B, Seki S, Miyazaki M, Ishihara M, Okada S, Imagama S, Kato S

Scientific reports 13 ( 1 ) 2689 2023.02

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DOI： 10.1038/s41598-023-29877-2

PubMed
Periostin increased by mechanical stress upregulates interleukin-6 expression in the ligamentum flavum.

Yabu A, Suzuki A, Hayashi K, Hori Y, Terai H, Orita K, Habibi H, Salimi H, Kono H, Toyoda H, Maeno T, Takahashi S, Tamai K, Ozaki T, Iwamae M, Ohyama S, Imai Y, Nakamura H

FASEB journal : official publication of the Federation of American Societies for Experimental Biology 37 ( 2 ) e22726 2023.02（ ISSN:0892-6638 ）

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DOI： 10.1096/fj.202200917RR

PubMed
Risk Factors for Early Mortality in Older Patients with Traumatic Cervical Spine Injuries-A Multicenter Retrospective Study of 1512 Cases.

Kobayashi M, Yokogawa N, Kato S, Sasagawa T, Tsuchiya H, Nakashima H, Segi N, Ito S, Funayama T, Eto F, Yamaji A, Yamane J, Nori S, Furuya T, Yunde A, Nakajima H, Yamada T, Hasegawa T, Terashima Y, Hirota R, Suzuki H, Imajo Y, Ikegami S, Uehara M, Tonomura H, Sakata M, Hashimoto K, Onoda Y, Kawaguchi K, Haruta Y, Suzuki N, Kato K, Uei H, Sawada H, Nakanishi K, Misaki K, Terai H, Tamai K, Kuroda A, Inoue G, Kakutani K, Kakiuchi Y, Kiyasu K, Tominaga H, Tokumoto H, Iizuka Y, Takasawa E, Akeda K, Takegami N, Funao H, Oshima Y, Kaito T, Sakai D, Yoshii T, Ohba T, Otsuki B, Seki S, Miyazaki M, Ishihara M, Okada S, Imagama S, Watanabe K

Journal of clinical medicine 12 ( 2 ) 2023.01（ ISSN:2077-0383 ）

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DOI： 10.3390/jcm12020708

PubMed
SPINE20 recommendations 2023: One Earth, one family, one future WITHOUT spine DISABILITY.

Chhabra HS, Tamai K, Alsebayel H, AlEissa S, Alqahtani Y, Arand M, Basu S, Blattert TR, Bussières A, Campello M, Costanzo G, Côté P, Darwano B, Franke J, Garg B, Hasan R, Ito M, Kamra K, Kandziora F, Kassim N, Kato S, Lahey D, Mehta K, Menezes CM, Muehlbauer EJ, Mullerpatan R, Pereira P, Roberts L, Ruosi C, Sullivan W, Shetty AP, Tucci C, Wadhwa S, Alturkistany A, Busari JO, Wang JC, Teli MGA, Rajasekaran S, Mulukutla RD, Piccirillo M, Hsieh PC, Dohring EJ, Srivastava SK, Larouche J, Vlok A, Nordin M

Brain & spine 3 102688 2023

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DOI： 10.1016/j.bas.2023.102688

PubMed
Effect of low body mass index on clinical recovery after fusion surgery for osteoporotic vertebral fracture: A retrospective, multicenter study of 237 cases.

Inoue G, Miyagi M, Saito W, Shirasawa E, Uchida K, Hosogane N, Watanabe K, Katsumi K, Kaito T, Yamashita T, Fujiwara H, Nagamoto Y, Nojiri K, Suzuki S, Okada E, Ueda S, Hikata T, Shiono Y, Watanabe K, Terai H, Tamai K, Matsuoka Y, Suzuki H, Nishimura H, Tagami A, Yamada S, Adachi S, Ohtori S, Furuya T, Orita S, Inage K, Yoshii T, Ushio S, Funao H, Isogai N, Harimaya K, Okada S, Kawaguchi K, Yokoyama N, Oishi H, Doi T, Kiyasu K, Imagama S, Ando K, Kobayashi K, Sakai D, Tanaka M, Kimura A, Inoue H, Nakano A, Ikegami S, Shimizu M, Futatsugi T, Kakutani K, Yurube T, Nakanishi K, Oshima M, Uei H, Aoki Y, Takahata M, Iwata A, Endo H, Seki S, Murakami H, Kato S, Yoshioka K, Hongo M, Abe T, Tsukanishi T, Takaso M, Ishii K

Medicine 101 ( 52 ) e32330 2022.12（ ISSN:0025-7974 ）

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DOI： 10.1097/MD.0000000000032330

PubMed
Delayed aortic injury after thoracic corrective osteotomy: a case report

Masuda Sho, Suzuki Akinobu, Takahashi Shinji, Tamai Koji, Nakamura Hiroaki

European Spine Journal 31 ( 12 ) 3703 - 3707 2022.12（ ISSN:0940-6719 ）（ eISSN:14320932 ）

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Case Report

DOI： 10.1007/s00586-021-07014-9

PubMed

CiNii Research
SPINE20 recommendations 2022: spine care-working together to recover stronger.

Darwono B, Tamai K, Côté P, Aleissa S, Rahim AH, Pereira P, Alsobayel H, Chhabra HS, Costanzo G, Ito M, Kandziora F, Lahey D, Menezes CM, Bajammal S, Sullivan WJ, Vajkoczy P, Ahmad A, Arand M, Asmiragani S, Blattert TR, Busari J, Dohring EJ, Misaggi B, Muehlbauer EJ, Mulukutla RD, Munting E, Piccirillo M, Ruosi C, Alturkistany A, Campello M, Hsieh PC, Teli MGA, Wang JC, Nordin M

European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society 31 ( 12 ) 3262 - 3273 2022.12（ ISSN:0940-6719 ）

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DOI： 10.1007/s00586-022-07432-3

PubMed
Prevalence, risk factors, and potential symptoms of hyponatremia after spinal surgery in elderly patients.

Kinoshita Y, Tamai K, Oka M, Habibi H, Terai H, Hoshino M, Toyoda H, Suzuki A, Takahashi S, Nakamura H

Scientific reports 12 ( 1 ) 18622 2022.11

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DOI： 10.1038/s41598-022-23583-1

PubMed
Increased Surgical Experience in Microendoscopic Spinal Surgery Can Reduce Development of Postoperative Spinal Epidural Hematoma and Improve the Clinical Outcomes.

Iwamae M, Tamai K, Kaneda K, Terai H, Katsuda H, Shimada N, Nakamura H

Journal of clinical medicine 11 ( 21 ) 2022.11（ ISSN:2077-0383 ）

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DOI： 10.3390/jcm11216495

PubMed
特集整形外科領域における人工知能の応用各論人工知能を活用した骨粗鬆症性椎体骨折の画像診断補助システム-MR画像における新鮮椎体骨折の識別

藪晋人, 星野雅俊, 田淵仁志, 高橋真治, 寺井秀富, 升本浩紀, 前野考史, 岩前真由, 豊田宏光, 鈴木亨暢, 玉井孝司, 猪瀬弘之, 吉井俊貴, 大川淳, 中村博亮

臨床整形外科 57 ( 10 ) 1205 - 1211 2022.10（ ISSN:05570433 ）（ eISSN:18821286 ）

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DOI： 10.11477/mf.1408202457

CiNii Research
Does surgery improve neurological outcomes in older individuals with cervical spinal cord injury without bone injury? A multicenter study.

Nori S, Watanabe K, Takeda K, Yamane J, Kono H, Yokogawa N, Sasagawa T, Ando K, Nakashima H, Segi N, Funayama T, Eto F, Yamaji A, Furuya T, Yunde A, Nakajima H, Yamada T, Hasegawa T, Terashima Y, Hirota R, Suzuki H, Imajo Y, Ikegami S, Uehara M, Tonomura H, Sakata M, Hashimoto K, Onoda Y, Kawaguchi K, Haruta Y, Suzuki N, Kato K, Uei H, Sawada H, Nakanishi K, Misaki K, Terai H, Tamai K, Shirasawa E, Inoue G, Kiyasu K, Iizuka Y, Takasawa E, Funao H, Kaito T, Yoshii T, Ishihara M, Okada S, Imagama S, Kato S

Spinal cord 60 ( 10 ) 895 - 902 2022.10（ ISSN:1362-4393 ）

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DOI： 10.1038/s41393-022-00818-6

PubMed
Factors Affecting the Waiting Time from Injury to Surgery in Elderly Patients with a Cervical Spine Injury: A Japanese Multicenter Survey.

Uehara M, Ikegami S, Takizawa T, Oba H, Yokogawa N, Sasagawa T, Ando K, Nakashima H, Segi N, Funayama T, Eto F, Yamaji A, Watanabe K, Nori S, Takeda K, Furuya T, Yunde A, Nakajima H, Yamada T, Hasegawa T, Terashima Y, Hirota R, Suzuki H, Imajo Y, Tonomura H, Sakata M, Hashimoto K, Onoda Y, Kawaguchi K, Haruta Y, Suzuki N, Kato K, Uei H, Sawada H, Nakanishi K, Misaki K, Terai H, Tamai K, Shirasawa E, Inoue G, Kakutani K, Kakiuchi Y, Kiyasu K, Tominaga H, Tokumoto H, Iizuka Y, Takasawa E, Akeda K, Takegami N, Funao H, Oshima Y, Kaito T, Sakai D, Yoshii T, Otsuki B, Seki S, Miyazaki M, Ishihara M, Okada S, Imagama S, Kato S

World neurosurgery 166 e815 - e822 2022.10（ ISSN:1878-8750 ）

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DOI： 10.1016/j.wneu.2022.07.104

PubMed
Differences in clinical characteristics of cervical spine injuries in older adults by external causes: a multicenter study of 1512 cases.

Yokogawa N, Kato S, Sasagawa T, Hayashi H, Tsuchiya H, Ando K, Nakashima H, Segi N, Funayama T, Eto F, Yamaji A, Nori S, Yamane J, Furuya T, Yunde A, Nakajima H, Yamada T, Hasegawa T, Terashima Y, Hirota R, Suzuki H, Imajo Y, Ikegami S, Uehara M, Tonomura H, Sakata M, Hashimoto K, Onoda Y, Kawaguchi K, Haruta Y, Suzuki N, Kato K, Uei H, Sawada H, Nakanishi K, Misaki K, Terai H, Tamai K, Shirasawa E, Inoue G, Kakutani K, Kakiuchi Y, Kiyasu K, Tominaga H, Tokumoto H, Iizuka Y, Takasawa E, Akeda K, Takegami N, Funao H, Oshima Y, Kaito T, Sakai D, Yoshii T, Ohba T, Otsuki B, Seki S, Miyazaki M, Ishihara M, Okada S, Imagama S, Watanabe K

Scientific reports 12 ( 1 ) 15867 2022.09

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DOI： 10.1038/s41598-022-19789-y

PubMed
Postoperative Physical Therapy Program Focused on Low Back Pain Can Improve Treatment Satisfaction after Minimally Invasive Lumbar Decompression.

Terai H, Tamai K, Kaneda K, Omine T, Katsuda H, Shimada N, Kobayashi Y, Nakamura H

Journal of clinical medicine 11 ( 19 ) 2022.09（ ISSN:2077-0383 ）

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DOI： 10.3390/jcm11195566

PubMed
Change in Physical and Mental Quality-of-Life between the Short- and Mid-Term Periods after Cervical Laminoplasty for Cervical Spondylotic Myelopathy: A Retrospective Cohort Study with Minimum 5 Years Follow-up.

Tamai K, Suzuki A, Terai H, Kato M, Toyoda H, Takahashi S, Yabu A, Sawada Y, Iwamae M, Nakamura H

Journal of clinical medicine 11 ( 17 ) 2022.09（ ISSN:2077-0383 ）

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DOI： 10.3390/jcm11175230

PubMed
A multicenter study of 1-year mortality and walking capacity after spinal fusion surgery for cervical fracture in elderly patients.

Sasagawa T, Yokogawa N, Hayashi H, Tsuchiya H, Ando K, Nakashima H, Segi N, Watanabe K, Nori S, Takeda K, Furuya T, Yunde A, Ikegami S, Uehara M, Suzuki H, Imajo Y, Funayama T, Eto F, Yamaji A, Hashimoto K, Onoda Y, Kakutani K, Kakiuchi Y, Suzuki N, Kato K, Terashima Y, Hirota R, Yamada T, Hasegawa T, Kawaguchi K, Haruta Y, Seki S, Tonomura H, Sakata M, Uei H, Sawada H, Tominaga H, Tokumoto H, Kaito T, Iizuka Y, Takasawa E, Oshima Y, Terai H, Tamai K, Otsuki B, Miyazaki M, Nakajima H, Nakanishi K, Misaki K, Inoue G, Kiyasu K, Akeda K, Takegami N, Yoshii T, Ishihara M, Okada S, Aoki Y, Harimaya K, Murakami H, Ishii K, Ohtori S, Imagama S, Kato S

BMC musculoskeletal disorders 23 ( 1 ) 798 2022.08

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DOI： 10.1186/s12891-022-05752-5

PubMed
Decreased daily exercise since the COVID-19 pandemic and the deterioration of health-related quality of life in the elderly population: a population-based cross-sectional study.

Tamai K, Terai H, Takahashi S, Katsuda H, Shimada N, Habibi H, Nakamura H

BMC geriatrics 22 ( 1 ) 678 2022.08

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DOI： 10.1186/s12877-022-03316-9

PubMed
Incidence of postoperative progressive segment degeneration at decompression and adjacent segments after minimally invasive lumbar decompression surgery: a 5-year follow-up study.

Habibi H, Toyoda H, Terai H, Yamada K, Hoshino M, Suzuki A, Takahashi S, Tamai K, Salimi H, Hori Y, Yabu A, Nakamura H

Journal of neurosurgery. Spine 37 ( 1 ) 96 - 103 2022.07

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DOI： 10.3171/2021.12.SPINE211151

PubMed
SPINE20 recommendations 2021: spine care for people's health and prosperity.

Costanzo G, Misaggi B, Ricciardi L, AlEissa SI, Tamai K, Alhelal F, Alqahtani Y, Alsobayel HI, Arand M, Balsano M, Blattert TR, Brayda-Bruno M, Busari JO, Campello M, Chhabra HS, Tamburrelli FC, Côté P, Darwono B, Kandziora F, La Maida GA, Muehlbauer EJ, Mulukutla RD, Pereira P, Rajasekaran S, Rothenfluh DA, Sullivan WJ, Truumees E, Dohring EJ, Pigott T, Shetty AP, Teli MGA, Wang JC, Ames C, Anema JR, Bang A, Cheung KMC, Gross DP, Haldeman S, Minisola S, Mullerpatan R, Negrini S, Salmi LR, Spinelli MS, Vlok A, Yankey KP, Zaina F, Alturkistany A, Franke J, Liljenqvist UR, Piccirillo M, Nordin M

European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society 31 ( 6 ) 1333 - 1342 2022.06（ ISSN:0940-6719 ）

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DOI： 10.1007/s00586-022-07194-y

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Mid-term changes in spinopelvic sagittal alignment in lumbar spinal stenosis with coexisting degenerative spondylolisthesis or scoliosis after minimally invasive lumbar decompression surgery: minimum five-year follow-up

Salimi Hamidullah, Toyoda Hiromitsu, Terai Hidetomi, Yamada Kentaro, Hoshino Masatoshi, Suzuki Akinobu, Takahashi Shinji, Tamai Koji, Hori Yusuke, Yabu Akito, Nakamura Hiroaki

The Spine Journal 22 ( 5 ) 819 - 826 2022.05（ ISSN:1529-9430 ）

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BACKGROUND CONTEXT : Recently, the number of patients with lumbar spinal stenosis (LSS) who present with a coexisting spinal deformity such as degenerative spondylolisthesis (DS) and scoliosis (DLS) has been increasing. Lumbar decompression without fusion can lead to a reactive improvement in the lumbar and sagittal spinopelvic alignment, even if a sagittal imbalance exists preoperatively. However, ......

DOI： 10.1016/j.spinee.2021.11.012

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Relationship between facet joint opening on CT and facet joint effusion on MRI in patients with lumbar spinal stenosis: analysis of a less invasive decompression procedure.

Yamada K, Toyoda H, Takahashi S, Tamai K, Suzuki A, Hoshino M, Terai H, Nakamura H

Journal of neurosurgery. Spine 36 ( 3 ) 376 - 384 2022.03

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DOI： 10.3171/2021.6.SPINE21721

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Facet Joint Opening on Computed Tomography Is a Predictor of Poor Clinical Outcomes After Minimally Invasive Decompression Surgery for Lumbar Spinal Stenosis.

Yamada K, Toyoda H, Takahashi S, Tamai K, Suzuki A, Hoshino M, Terai H, Nakamura H

Spine 47 ( 5 ) 405 - 413 2022.03（ ISSN:0362-2436 ）

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DOI： 10.1097/BRS.0000000000004262

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A deep learning algorithm to identify cervical ossification of posterior longitudinal ligaments on radiography.

Tamai K, Terai H, Hoshino M, Yabu A, Tabuchi H, Sasaki R, Nakamura H

Scientific reports 12 ( 1 ) 2113 2022.02

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DOI： 10.1038/s41598-022-06140-8

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The health-related quality of life of patients with musculoskeletal disorders after the COVID-19 pandemic.

Terai H, Tamai K, Takahashi S, Hori Y, Iwamae M, Ohyama S, Yabu A, Hoshino M, Nakamura H

International orthopaedics 46 ( 2 ) 189 - 195 2022.02（ ISSN:0341-2695 ）

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DOI： 10.1007/s00264-021-05256-2

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Impact of the COVID-19 Pandemic on Elderly Patients with Spinal Disorders.

Terai H, Takahashi S, Tamai K, Hori Y, Iwamae M, Hoshino M, Ohyama S, Yabu A, Nakamura H

Journal of clinical medicine 11 ( 3 ) 2022.01（ ISSN:2077-0383 ）

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DOI： 10.3390/jcm11030602

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臨床室脊椎術後に発生した鉱質コルチコイド反応性低ナトリウム血症の1例

木下右貴, 玉井孝司, 寺井秀富, 豊田宏光, 鈴木亨暢, 中村博亮

整形外科 73 ( 1 ) 28 - 31 2022.01（ ISSN:00305901 ）（ eISSN:24329444 ）

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DOI： 10.15106/j_seikei73_28

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Improvements in Mental Well-Being and its Predictive Factors in Patients who Underwent Cervical versus Lumbar Decompression Surgery

Tamai Koji, Suzuki Akinobu, Toyoda Hiromitsu, Terai Hidetomi, Hoshino Masatoshi, Takahashi Shinji, Hori Yusuke, Yabu Akito, Nakamura Hiroaki

Spine Surgery and Related Research 6 ( 1 ) 10 - 16 2022（ eISSN:2432261X ）

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Introduction: Mental well-being is essential for patient satisfaction. Therefore, a better understanding of the changes in the mental well-being of patients following spinal surgery can be useful to surgeons. We compared the 2-year postoperative change in the mental well-being of patients who underwent cervical and lumbar decompression surgery. Additionally, the predictive factors for improvement in mental well-being associated with both methods were evaluated.Methods: The patients who underwent spinal decompression surgery and were followed >2 years postoperatively were enrolled (lumbar cohort: n=111, cervical cohort: n=121). The 36-item Short-Form Health Survey (SF-36) mental component summary (MCS) was set as the mental well-being parameter, and the minimal clinically important difference (MCID) was defined as 4.0. After adjusting the cervical and lumbar cohorts using propensity scores, the improvements in the MCS were compared between the groups using a mixed-effect model. To identify predictors for improvements, the correlation between the MCS changes and preoperative clinical scores was evaluated. Subsequently, multivariate linear regression was applied, which included variables with p<0.10 in the former analysis as explanatory variables, and the change of MCS as the objective variable.Results: There were no significant differences in the MCS improvement between the adjusted cervical and lumbar cohorts; 47% and 49%, respectively, had MCS improvement score >MCIDs. However, predictors for the improvement were different between the two cohorts: SF-36 Social functioning in cervical surgery and lower back pain and SF-36 Role physical in lumbar surgery.Conclusions: Although there was no significant difference in the improvement in the mental well-being between patients who underwent either cervical or lumbar decompression surgery, less than half of the patients in both groups achieved a meaningful improvement. Preoperative back pain and personal activity were independent predictors in the lumbar cohort, while social functioning was the only predictor in the cervical cohort.Level of evidence: III

DOI： 10.22603/ssrr.2021-0060

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Is Blood Loss Greater in Elderly Patients under Antiplatelet or Anticoagulant Medication for Cervical Spine Injury Surgery? A Japanese Multicenter Survey

Uehara Masashi, Ikegami Shota, Takizawa Takashi, Oba Hiroki, Yokogawa Noriaki, Sasagawa Takeshi, Ando Kei, Nakashima Hiroaki, Segi Naoki, Funayama Toru, Eto Fumihiko, Yamaji Akihiro, Watanabe Kota, Nori Satoshi, Takeda Kazuki, Furuya Takeo, Orita Sumihisa, Nakajima Hideaki, Yamada Tomohiro, Hasegawa Tomohiko, Terashima Yoshinori, Hirota Ryosuke, Suzuki Hidenori, Imajo Yasuaki, Tonomura Hitoshi, Sakata Munehiro, Hashimoto Ko, Onoda Yoshito, Kawaguchi Kenichi, Haruta Yohei, Suzuki Nobuyuki, Kato Kenji, Uei Hiroshi, Sawada Hirokatsu, Nakanishi Kazuo, Misaki Kosuke, Terai Hidetomi, Tamai Koji, Shirasawa Eiki, Inoue Gen, Kakutani Kenichiro, Kakiuchi Yuji, Kiyasu Katsuhito, Tominaga Hiroyuki, Tokumoto Hiroto, Iizuka Yoichi, Takasawa Eiji, Akeda Koji, Takegami Norihiko, Funao Haruki, Oshima Yasushi, Kaito Takashi, Sakai Daisuke, Yoshii Toshitaka, Ohba Tetsuro, Otsuki Bungo, Seki Shoji, Miyazaki Masashi, Ishihara Masayuki, Okada Seiji, Aoki Yasuchika, Harimaya Katsumi, Murakami Hideki, Ishii Ken, Ohtori Seiji, Imagama Shiro, Kato Satoshi

Spine Surgery and Related Research 6 ( 4 ) 366 - 372 2022（ eISSN:2432261X ）

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Introduction: In elderly patients with cervical spinal cord injury, comorbidities such as cardiovascular and cerebrovascular diseases are common, with frequent administration of antiplatelet/anticoagulant (APAC) drugs. Such patients may bleed easily or unexpectedly during surgery despite prior withdrawal of APAC medication. Few reports have examined the precise relationship between intraoperative blood loss and history of APAC use regarding surgery for cervical spine injury in the elderly. The present multicenter database survey aimed to answer the question of whether the use of APAC drugs affected the amount of intraoperative blood loss in elderly patients with cervical spinal cord trauma.Methods: The case histories of 1512 patients with cervical spine injury at 33 institutes were retrospectively reviewed. After excluding cases without spinal surgery or known blood loss volume, 797 patients were enrolled. Blood volume loss was the outcome of interest. We calculated propensity scores using the inverse probability of treatment weighting (IPTW) method. As an alternative sensitivity analysis, linear mixed model analyses were conducted as well.Results: Of the 776 patients (mean age: 75.1±6.4 years) eligible for IPTW calculation, 157 (20.2%) were taking APAC medications before the injury. After weighting, mean estimated blood loss was 204 mL for non-APAC patients and 215 mL for APAC patients. APAC use in elderly patients was not significantly associated with surgical blood loss according to the IPTW method with propensity scoring or linear mixed model analyses. Thus, it appeared possible to perform surgery expecting comparable blood loss in APAC and non-APAC cases.Conclusions: This multicenter study revealed no significant increase in surgical blood loss in elderly patients with cervical trauma taking APAC drugs. Surgeons may be able to prioritize patient background, complications, and preexisting conditions over APAC use before injury when examining the surgical indications for cervical spine trauma in the elderly.

DOI： 10.22603/ssrr.2021-0183

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経験と考察新型コロナウイルス感染症(COVID-19)流行による生活様式の変化に対して運動指導を希望する整形外科患者の特徴

馬野雅之, 寺井秀富, 玉井孝司, 勝田紘史, 島田永和, 中村博亮

整形外科 72 ( 13 ) 1327 - 1332 2021.12（ ISSN:00305901 ）（ eISSN:24329444 ）

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DOI： 10.15106/j_seikei72_1327

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Clinical Comparison of Combined Cortical Bone Trajectory and Transarticular Surface Screw Versus Standard Pedicle Screw Insertion by Wiltse Approach for L5 Isthmic Spondylolisthesis

Terai Hidetomi, Tamai Koji, Takahashi Shinji, Umano Masayuki, Iwamae Masayoshi, Toyoda Hiromitsu, Suzuki Akinobu, Hoshino Masatoshi, Nakamura Hiroaki

Clinical Spine Surgery 34 ( 10 ) E580 - E587 2021.12（ ISSN:2380-0186 ）

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Study Design: This was a retrospective cohort study. / Objective: The objective of this study was to assess the effectiveness and invasiveness of a combined screw insertion technique [using cortical bone trajectory (CBT) screw and transarticular surface screw (TASS)] for patients with L5 isthmic spondylolisthesis. / Summary of Background Data: Lumbosacral posterior fixation using TASS is safe, with high biomechanical strength. However, ......

DOI： 10.1097/BSD.0000000000001170

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Characteristics and Short-Term Surgical Outcomes of Patients with Recurrent Lumbar Disc Herniation after Percutaneous Laser Disc Decompression.

Terai H, Tamai K, Iwamae M, Kaneda K, Katsuda H, Shimada N, Nakamura H

Medicina (Kaunas, Lithuania) 57 ( 11 ) 2021.11（ ISSN:1010-660X ）

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DOI： 10.3390/medicina57111225

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Heated Tobacco Products Impair Cell Viability, Osteoblastic Differentiation, and Bone Fracture-Healing

Nishino Kazuya, Tamai Koji, Orita Kumi, Hashimoto Yusuke, Nakamura Hiroaki

The Journal of Bone and Joint Surgery 103 ( 21 ) 2024 - 2031 2021.11（ ISSN:0021-9355 ）（ eISSN:15351386 ）

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DOI： 10.2106/JBJS.20.02227

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Prevalence of Restless Legs Syndrome and its Symptoms among Patients with Spinal Disorders.

Terai H, Toyoda H, Hoshino M, Suzuki A, Takahashi S, Tamai K, Ohyama S, Yabu A, Nakamura H

Journal of clinical medicine 10 ( 21 ) 2021.10（ ISSN:2077-0383 ）

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DOI： 10.3390/jcm10215001

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Using artificial intelligence to diagnose fresh osteoporotic vertebral fractures on magnetic resonance images.

Yabu A, Hoshino M, Tabuchi H, Takahashi S, Masumoto H, Akada M, Morita S, Maeno T, Iwamae M, Inose H, Kato T, Yoshii T, Tsujio T, Terai H, Toyoda H, Suzuki A, Tamai K, Ohyama S, Hori Y, Okawa A, Nakamura H

The spine journal : official journal of the North American Spine Society 21 ( 10 ) 1652 - 1658 2021.10（ ISSN:1529-9430 ）

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DOI： 10.1016/j.spinee.2021.03.006

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Clinical outcomes of laminoplasty for patients with lysosomal storage disease including mucopolysaccharidosis and mucolipidoses: a retrospective cohort study.

Terai H, Tamai K, Hoshino M, Toyoda H, Suzuki A, Takahashi S, Hori Y, Yabu A, Nakamura H

Orphanet journal of rare diseases 16 ( 1 ) 401 2021.09

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DOI： 10.1186/s13023-021-02031-9

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Clinical Outcomes of Minimally Invasive Posterior Decompression for Lumbar Spinal Stenosis with Degenerative Spondylolisthesis

Kobayashi Yuto, Tamai Koji, Toyoda Hiromitsu, Terai Hidetomi, Hoshino Masatoshi, Suzuki Akinobu, Takahashi Shinji, Hori Yusuke, Yabu Akito, Nakamura Hiroaki

Spine 46 ( 18 ) 1218 - 1225 2021.09（ ISSN:0362-2436 ）（ eISSN:15281159 ）

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Study Design: Retrospective cohort study. / Objective: To compare the clinical outcomes 5 years after minimally invasive posterior decompression for lumber spinal stenosis (LSS) between patients with and without degenerative spondylolisthesis (DS). ...

DOI： 10.1097/BRS.0000000000003997

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Direct Lateral Corpectomy and Reconstruction Using an Expandable Cage Improves Local Kyphosis but Not Global Sagittal Alignment.

Terai H, Takahashi S, Yasuda H, Konishi S, Maeno T, Kono H, Matsumura A, Namikawa T, Kato M, Hoshino M, Tamai K, Toyoda H, Suzuki A, Nakamura H

Journal of clinical medicine 10 ( 17 ) 2021.09（ ISSN:2077-0383 ）

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DOI： 10.3390/jcm10174012

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The effect of minimally invasive lumbar decompression surgery on sagittal spinopelvic alignment in patients with lumbar spinal stenosis: a 5-year follow-up study.

Salimi H, Toyoda H, Yamada K, Terai H, Hoshino M, Suzuki A, Takahashi S, Tamai K, Hori Y, Yabu A, Nakamura H

Journal of neurosurgery. Spine 35 ( 2 ) 177 - 184 2021.08

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DOI： 10.3171/2020.11.SPINE201552

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SPINE20 A global advocacy group promoting evidence-based spine care of value.

AlEissa SI, Tamai K, Konbaz F, Alturkistany A, Blattert TR, Chhabra HS, Costanzo G, Dohring EJ, Kandziora F, Kothe R, Misaggi B, Muehlbauer EJ, Pereira P, Rajasekaran S, Sullivan WJ, Truumees E, Alqahtani Y, Alsobayel HI, Franke J, Teli MGA, Wang JC, Al-Hazzaa HM, Alosaimi MN, Berven S, Brayda-Bruno M, Briggs AM, Busari JO, Caserta AV, Côté P, Crostelli M, Fehlings MG, Gunzburg R, Haddadin S, Ihm J, Hilibrand AS, Luca A, Osvaldo M, Pigott T, Rothenfluh DA, Ruosi C, Salmi LR, Shetty AP, Singh K, Vaccaro AR, Wong DA, Zileli M, Nordin M

European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society 30 ( 8 ) 2091 - 2101 2021.08（ ISSN:0940-6719 ）

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DOI： 10.1007/s00586-021-06890-5

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Can Conventional Magnetic Resonance Imaging Substitute Three-Dimensional Magnetic Resonance Imaging in the Diagnosis of Lumbar Foraminal Stenosis?

Hasib MM, Yamada K, Hoshino M, Yamada E, Tamai K, Takahashi S, Suzuki A, Toyoda H, Terai H, Nakamura H

Asian spine journal 15 ( 4 ) 472 - 480 2021.08（ ISSN:1976-1902 ）

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DOI： 10.31616/asj.2020.0133

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Differences in surgical outcome after anterior corpectomy and reconstruction with an expandable cage with rectangular footplates between thoracolumbar and lumbar osteoporotic vertebral fracture.

Terai H, Takahashi S, Yasuda H, Konishi S, Maeno T, Kono H, Matsumura A, Namikawa T, Kato M, Hoshino M, Tamai K, Toyoda H, Suzuki A, Nakamura H

North American Spine Society journal 6 100071 2021.06

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DOI： 10.1016/j.xnsj.2021.100071

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Expression and function of FGF9 in the hypertrophied ligamentum flavum of lumbar spinal stenosis patients.

Habibi H, Suzuki A, Hayashi K, Salimi H, Terai H, Hori Y, Tamai K, Orita K, Ohyama S, Yabu A, Maruf MH, Nakamura H

The spine journal : official journal of the North American Spine Society 21 ( 6 ) 1010 - 1020 2021.06（ ISSN:1529-9430 ）

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DOI： 10.1016/j.spinee.2021.02.004

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Risk Factor for Poor Patient Satisfaction After Lumbar Spine Surgery in Elderly Patients Aged Over 80 years.

Hikata T, Ishii K, Matsumoto M, Kobayashi K, Imagama S, Ando K, Ishiguro N, Yamashita M, Seki S, Terai H, Suzuki A, Tamai K, Aramomi M, Ishikawa T, Kimura A, Inoue H, Inoue G, Miyagi M, Saito W, Yamada K, Hongo M, Endo K, Suzuki H, Nakano A, Watanabe K, Ohya J, Chikuda H, Aoki Y, Shimizu M, Futatsugi T, Mukaiyama K, Hasegawa M, Kiyasu K, Iizuka H, Kobayashi R, Iizuka Y, Nishida K, Kakutani K, Nakajima H, Murakami H, Demura S, Kato S, Yoshioka K, Namikawa T, Watanabe K, Nakanishi K, Nakagawa Y, Yoshimoto M, Fujiwara H, Nishida N, Imajo Y, Yamazaki M, Abe T, Fujii K, Kaito T, Eguchi Y, Furuya T, Orita S, Ohtori S

Clinical spine surgery 34 ( 4 ) E223 - E228 2021.05（ ISSN:2380-0186 ）

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DOI： 10.1097/BSD.0000000000001101

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Classification and prognostic factors of residual symptoms after minimally invasive lumbar decompression surgery using a cluster analysis: a 5-year follow-up cohort study

Toyoda Hiromitsu, Yamada Kentaro, Terai Hidetomi, Hoshino Masatoshi, Suzuki Akinobu, Takahashi Shinji, Tamai Koji, Ohyama Shoichiro, Hori Yusuke, Yabu Akito, Salimi Hamidullah, Nakamura Hiroaki

European Spine Journal 30 ( 4 ) 918 - 927 2021.04（ ISSN:0940-6719 ）（ eISSN:14320932 ）

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Purpose: Residual symptoms indicating incomplete remission of lower leg numbness or low back pain may occur after spine surgery. The purpose was to elucidate the pattern of residual symptoms 5 years after minimally invasive lumbar decompression surgery using a cluster analysis. ...

DOI： 10.1007/s00586-021-06754-y

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Time Course of Physical and Mental Well-being Improvements After Cervical Surgery

Tamai Koji, Suzuki Akinobu, Terai Hidetomi, Hoshino Masatoshi, Toyoda Hiromitsu, Takahashi Shinji, Hori Yusuke, Yabu Akito, Nakamura Hiroaki

Spine 46 ( 5 ) E303 - E309 2021.03（ ISSN:0362-2436 ）（ eISSN:15281159 ）

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Study Design: Retrospective cohort study. / Objective: To elucidate the postoperative time course of improvements in physical and mental well-being in patients with cervical spondylotic myelopathy (CSMI. …

DOI： 10.1097/BRS.0000000000003787

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Biglycan expression and its function in human ligamentum flavum.

Salimi H, Suzuki A, Habibi H, Orita K, Hori Y, Yabu A, Terai H, Tamai K, Nakamura H

Scientific reports 11 ( 1 ) 4867 2021.03

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DOI： 10.1038/s41598-021-84363-x

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The short-term outcomes of minimally invasive decompression surgery in patients with lumbar ossification or calcification of the ligamentum flavum.

Tamai K, Kaneda K, Iwamae M, Terai H, Katsuda H, Shimada N, Nakamura H

Journal of neurosurgery. Spine 34 ( 2 ) 203 - 210 2021.02

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DOI： 10.3171/2020.6.SPINE20946

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Impact of High-intensity Zones on Their Corresponding Lumbar Spine Segments: A Propensity Score-matched Analysis.

Chen X, Tamai K, Yang JJ, Shah ID, Paholpak P, Wang JC, Buser Z

Clinical spine surgery 34 ( 1 ) 32 - 38 2021.02（ ISSN:2380-0186 ）

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DOI： 10.1097/BSD.0000000000000991

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Presence of sarcopenia does not affect the clinical results of balloon kyphoplasty for acute osteoporotic vertebral fracture.

Ohyama S, Hoshino M, Takahashi S, Hori Y, Yasuda H, Terai H, Hayashi K, Tsujio T, Kono H, Suzuki A, Tamai K, Toyoda H, Dohzono S, Nakamura H

Scientific reports 11 ( 1 ) 122 2021.01

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DOI： 10.1038/s41598-020-80129-z

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Surgical Outcomes of a New Technique Using a Convex Rod Rotation Maneuver for Adolescent Idiopathic Scoliosis

Takahashi Shinji, Terai Hidetomi, Toyoda Hiromitsu, Hoshino Masatoshi, Suzuki Akinobu, Tamai Koji, Ohyama Shoichiro, Hori Yusuke, Yabu Akito, Nakamura Hiroaki

Spine Surgery and Related Research 5 ( 3 ) 205 - 210 2021（ eISSN:2432261X ）

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Introduction: Because of adolescent idiopathic scoliosis (AIS), most surgeons use rod rotation on the concave side for Lenke types 1 and 2 curves. Nevertheless, the accurate placement of pedicle screws within dysplastic pedicles, especially on the concave side, is sometimes challenging. Conversely, there is a concern that apical rotation might be exacerbated after convex rod rotation maneuver (RRM) because the rod is rotated in the same direction as vertebral rotation. This study aims to demonstrate the surgical technique and outcomes of a convex RRM with direct vertebral rotation (DVR) for the correction of AIS.Technical Note: Multilevel pedicle screws were inserted into the vertebrae. The pre-bent pure titanium rod was set on the convex side and then derotated to nearly 90°. DVR was conducted for the desired vertebrae. Another pre-bent titanium alloy rod, for placement on the concave side, was contoured the same as the rod on the convex side. Using a reduction tube that allowed easier capture of the rod, the rod was connected to the concave side screws. DVR was again conducted for the desired vertebrae. Among the 59 patients, the correction rate of the main thoracic curve in Lenke types 1 and 2 AIS was 75.1% and 65.0%, respectively. The absolute value of the change in apical vertebral rotation between pre- and post-operative computed tomography (CT) scans in Lenke types 1 and 2 curves was 4.8° and 4.2°, respectively.Conclusions: The convex RRM improved vertebral rotation in Lenke types 1 and 2 AIS. This procedure should be regarded as one of the surgical options for AIS, especially in patients with a narrow pedicle width on the concave side.

DOI： 10.22603/ssrr.2020-0185

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Percutaneous Endovascular Retrieval of Large Cement Leakage into the Right Atrium Following Cement-Augmented Pedicle Screw Instrumentation

Takahashi Shinji, Sohgawa Etsuji, Suzuki Akinobu, Yamamoto Akira, Sasaki Ryo, Tanaka Katsuaki, Terai Hidetomi, Hoshino Masatoshi, Toyoda Hiromitsu, Tamai Koji, Nakamura Hiroaki

Spine Surgery and Related Research 5 ( 6 ) 446 - 449 2021（ eISSN:2432261X ）

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DOI： 10.22603/ssrr.2021-0011

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Reductions in the Frequency of Going Out Due to the COVID-19 Pandemic Negatively Affect Patients with Spinal Disorders

Terai Hidetomi, Iwamae Masayoshi, Tamai Koji, Takahashi Shinji, Hori Yusuke, Ohyama Shoichiro, Yabu Akito, Hoshino Masatoshi, Nakamura Hiroaki

Spine Surgery and Related Research 5 ( 6 ) 365 - 374 2021（ eISSN:2432261X ）

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Introduction: The coronavirus disease 2019 (COVID-19) pandemic has greatly changed the lifestyles of individuals due to the need to prevent disease spread. Globally, governments have enforced various policies, including travel bans, quarantine, home confinement, and lockdowns, as safety measures. Consequently, the frequency of individuals going out has decreased. This survey aimed to assess how decreasing the frequency of going out due to the COVID-19 pandemic impacts patients with spinal disorders.Methods: This multicenter cross-sectional questionnaire survey included patients who visited four private spine clinics for any symptoms. Participants completed questionnaires pre- and post-pandemic that assessed the following topics: frequency of leaving home, exercise habits, locomotive syndrome, and health-related quality of life (HRQOL). Patients were divided into decreased and non-decreased frequency of going out groups, according to observed changes in their frequencies of leaving home. Both groups were statistically compared using univariate and multivariate logistic regression analyses to identify factors associated with the frequency of going out.Results: Among 855 patients, 160 (18.7%; the decreased group) reported that they went out less frequently, and 695 (81.3%; the non-decreased group) reported that they left home equally frequently post- versus pre-pandemic. Multivariate analyses showed that exercise habits significantly decreased (adjusted odds ratio (aOR) = 2.67, p = 0.004), the incidence of locomotive syndrome significantly increased (aOR = 2.86, p = 0.012), and HRQOL significantly deteriorated (aOR = 4.14, p < 0.001) in the decreased group compared to the non-decreased group.Conclusions: Restrictions regarding leaving home due to the COVID-19 pandemic significantly decreased exercise frequency, increased the occurrence of locomotive syndrome, and were associated with deterioration of HRQOL in patients with spine disorders. It may be beneficial for spine surgeons to encourage patients with spinal disorders to leave home at a frequency similar to what they did pre-pandemic while avoiding crowded areas, despite the presence of the COVID-19 pandemic.

DOI： 10.22603/ssrr.2021-0088

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Do rheumatoid arthritis patients have low back pain or radiological lumbar lesions more frequently than the healthy population? : Cross-sectional analysis in a cohort study with age and sex-matched healthy volunteers

Suzuki Akinobu, Tamai Koji, Takahashi Shinji, Yamada Kentaro, Inui Kentaro, Tada Masahiro, Okano Tadashi, Sugioka Yuko, Koike Tatsuya, Nakamura Hiroaki

The Spine Journal 20 ( 12 ) 1995 - 2002 2020.12（ ISSN:1529-9430 ）

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BACKGROUND CONTEXT: Rheumatoid arthritis (RA) can affect the spine; however, the epidemiology of lumbar lesions and/or low back pain (LBP) in RA patients has not been well-studied. / PURPOSE: The purpose of this study was to compare the prevalence of lumbar lesions and LBP in RA patients with that in healthy volunteers, and to elucidate the influence of RA on lumbar disease....

DOI： 10.1016/j.spinee.2020.06.020

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The Severity of Cervical Disc Degeneration Does Not Impact 2-year Postoperative Outcomes in Patients With Cervical Spondylotic Myelopathy Who Underwent Laminoplasty

Habibi Hasibullah, Suzuki Akinobu, Tamai Koji, Ohyama Shoichiro, Hori Yusuke, Yabu Akito, Terai Hidetomi, Hoshino Masatoshi, Toyoda Hiromitsu, Takahashi Shinji, Ahmadi Sayed Abdullah, Nakamura Hiroaki

Spine 45 ( 18 ) E1142 - E1149 2020.09（ ISSN:0362-2436 ）（ eISSN:15281159 ）

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Study Design: Retrospective cohort study. / Objective: The aim of this study was to evaluate the impact of cervical disc degeneration (CDD) severity on 2-year postoperative outcomes following laminoplasty. / Summary of Background Data: The impact of CDD on postoperative outcomes of cervical laminoplasty has not been well established....

DOI： 10.1097/BRS.0000000000003528

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Short- versus long-segment posterior spinal fusion with vertebroplasty for osteoporotic vertebral collapse with neurological impairment in thoracolumbar spine: a multicenter study.

Ishikawa Y, Watanabe K, Katsumi K, Ohashi M, Shibuya Y, Izumi T, Hirano T, Endo N, Kaito T, Yamashita T, Fujiwara H, Nagamoto Y, Matsuoka Y, Suzuki H, Nishimura H, Terai H, Tamai K, Tagami A, Yamada S, Adachi S, Yoshii T, Ushio S, Harimaya K, Kawaguchi K, Yokoyama N, Oishi H, Doi T, Kimura A, Inoue H, Inoue G, Miyagi M, Saito W, Nakano A, Sakai D, Nukaga T, Ikegami S, Shimizu M, Futatsugi T, Ohtori S, Furuya T, Orita S, Imagama S, Ando K, Kobayashi K, Kiyasu K, Murakami H, Yoshioka K, Seki S, Hongo M, Kakutani K, Yurube T, Aoki Y, Oshima M, Takahata M, Iwata A, Endo H, Abe T, Tsukanishi T, Nakanishi K, Watanabe K, Hikata T, Suzuki S, Isogai N, Okada E, Funao H, Ueda S, Shiono Y, Nojiri K, Hosogane N, Ishii K

BMC musculoskeletal disorders 21 ( 1 ) 513 2020.08

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DOI： 10.1186/s12891-020-03539-0

PubMed
Effect of bisphosphonates or teriparatide on mechanical complications after posterior instrumented fusion for osteoporotic vertebral fracture: a multi-center retrospective study.

Kawabata A, Yoshii T, Hirai T, Ushio S, Kaito T, Yamashita T, Fujiwara H, Nagamoto Y, Matsuoka Y, Suzuki H, Nishimura H, Terai H, Tamai K, Tagami A, Yamada S, Adachi S, Watanabe K, Katsumi K, Ohashi M, Shibuya Y, Harimaya K, Kawaguchi K, Yokoyama N, Oishi H, Doi T, Kimura A, Inoue H, Inoue G, Miyagi M, Saito W, Nakano A, Sakai D, Nukaga T, Ikegami S, Shimizu M, Futatsugi T, Ohtori S, Furuya T, Orita S, Imagama S, Ando K, Kobayashi K, Kiyasu K, Murakami H, Yoshioka K, Seki S, Hongo M, Kakutani K, Yurube T, Aoki Y, Oshima M, Takahata M, Iwata A, Endo H, Abe T, Tsukanishi T, Nakanishi K, Watanabe K, Hikata T, Suzuki S, Isogai N, Okada E, Funao H, Ueda S, Shiono Y, Nojiri K, Hosogane N, Ishii K

BMC musculoskeletal disorders 21 ( 1 ) 420 2020.07

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DOI： 10.1186/s12891-020-03452-6

PubMed
The factors related to the poor ADL in the patients with osteoporotic vertebral fracture after instrumentation surgery.

Murata K, Matsuoka Y, Nishimura H, Endo K, Suzuki H, Takamatsu T, Sawaji Y, Aihara T, Kusakabe T, Maekawa A, Yamamoto K, Watanabe K, Kaito T, Terai H, Tamai K, Tagami A, Yoshii T, Harimaya K, Kawaguchi K, Kimura A, Inoue G, Nakano A, Sakai D, Hiyama A, Ikegami S, Ohtori S, Furuya T, Orita S, Imagama S, Kobayashi K, Kiyasu K, Murakami H, Yoshioka K, Seki S, Hongo M, Kakutani K, Yurube T, Aoki Y, Uei H, Ajiro Y, Takahata M, Endo H, Abe T, Nakanishi K, Watanabe K, Okada E, Hosogane N, Funao H, Isogai N, Ishii K

European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society 29 ( 7 ) 1597 - 1605 2020.07（ ISSN:0940-6719 ）

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DOI： 10.1007/s00586-019-06092-0

PubMed
Facet joint opening on preoperative computed tomography is risk factor for revision surgery after less invasive decompression procedure for lumbar spinal stenosis

Yamada Kentaro, Toyoda Hiromitsu, Tamai Koji, Takahashi Shinji, Suzuki Akinobu, Hoshino Masatoshi, Terai Hidetomi, Nakamura Hiroaki

Journal of Spine Research 11 ( 6 ) 936 - 941 2020.06（ ISSN:18847137 ）（ eISSN:24351563 ）

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Purpose: There is no consensus of regarding the indication of surgical treatment of the less invasive decompression procedure for lumbar spinal stenosis (LSS). Although facet joint opening (FO) on preoperative computed tomography (CT) images has been reported as a parameter indicating segmental instability, there is no report on how FO affects on postoperative outcomes. The purpose of this study was to investigate risk factors for revision surgery after less invasive decompression surgery for LSS including FO by a minimum-5-year postoperative survey.Materials and Methods: A total of 244 patients who underwent microscopic or microendoscopic decompression surgery for LSS and followed for ≥5 years were included in this study. We investigated revision lumbar surgeries at the same levels or other lumbar levels based on medical records. Revision surgeries due to postoperative hematoma or infection were excluded. FO was defined as a ≥2 mm opening on preoperative axial CT images at each lumbar intervertebral level. We evaluated the FO at index decompression levels and sum of FO-positive levels from L1-2 to L5-S. Risk factors for further surgeries were investigated among demographics, preoperative symptoms, and radiological parameters other than FO using univariate and cox proportional hazard regression analysis.Results: There was 26 reoperations (10.7%) at a mean of 3.9 years after primary surgeries. FO at index decompression levels was significantly more frequent in patients with than without revision surgeries (69 and 39%, respectively, p=0.003). The sum of FO-positive levels among lumbar segments was significantly higher in patients with than without revision surgeries (2.0 and 1.2 levels, respectively, p=0.001). The cox proportional hazard regression analysis indicated that the sum of FO-positive levels among lumbar segments was one of the risk factors for revision surgery (p=0.003, adjusted hazard ratio: 1.47).Conclusions: The FO of index decompression levels and sum of FO were associated with the need for further lumbar surgeries after less invasive surgery. FO might indicate not only segmental instability but also predictive parameter for progression of degenerative change.

DOI： 10.34371/jspineres.2020-0512

CiNii Research
Improvement in Patient Mental Well-being After Surgery for Cervical Spondylotic Myelopathy

Tamai Koji, Suzuki Akinobu, Terai Hidetomi, Hoshino Masatoshi, Toyoda Hiromitsu, Takahashi Shinji, Ohyama Shoichiro, Hori Yusuke, Yabu Akito, Nakamura Hiroaki

Spine 45 ( 10 ) E568 - E575 2020.05（ ISSN:0362-2436 ）（ eISSN:15281159 ）

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Study Design: Retrospective cohort study. / Objective: The aim of this study was to investigate changes in mental well-being after surgery for cervical spondylotic myelopathy (CSM) and identify factors associated with improvement….

DOI： 10.1097/BRS.0000000000003337

PubMed

CiNii Research
The effect of nicotine cessation on human bone marrow stem cell proliferation and differentiation into osteoblasts.

Tamai K, Formanek B, Chamnan R, Wang JC, Buser Z

The spine journal : official journal of the North American Spine Society 20 ( 2 ) 307 - 309 2020.02（ ISSN:1529-9430 ）

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DOI： 10.1016/j.spinee.2019.09.016

PubMed
Clinical Impact of Cervical Imbalance on Surgical Outcomes of Laminoplasty: A Propensity Score-Matching Analysis.

Tamai K, Suzuki A, Yabu A, Terai H, Hoshino M, Toyoda H, Takahashi S, Ohyama S, Hori Y, Nakamura H

Clinical spine surgery 33 ( 1 ) E1 - E7 2020.02（ ISSN:2380-0186 ）

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DOI： 10.1097/BSD.0000000000000849

PubMed
Patient-reported outcomes for cervical disease in end-stage renal disease patients: Propensity matching analysis using volunteer data

Tamai Koji, Yabu Akito, Takayama Kazushi, Kita Teruo, Sakanaka Hideki, Suzuki Akinobu, Nakamura Hiroaki

Journal of Clinical Neuroscience 72 130 - 133 2020.02（ ISSN:0967-5868 ）

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As the number of patients with end-stage renal disease (ESRD) has been increasing, the number of cervical spine surgeries for the patients with ESRD has also been increasing. The purpose is to identify the differences in cervical disease-specific patient-reported outcomes (PROs) between a healthy population and patients with ESRD, adjusting for subjects' age and physical activity. / [Methods] The ESRD group included patients with ESRD who were treated with hemodialysis in our outpatient clinic and healthy volunteers were individuals who attended public health lectures. Volunteers with a history of cervical disease were excluded. All participants answered the Japanese Orthopaedic Association Cervical Myelopathy Evaluation Questionnaire (JOACMEQ) and questionnaires that evaluate the disability in performing physical activities....

DOI： 10.1016/j.jocn.2019.12.045

PubMed

CiNii Research
The Surgical Outcomes of Spinal Fusion for Osteoporotic Vertebral Fractures in the Lower Lumbar Spine with a Neurological Deficit

Isogai Norihiro, Hosogane Naobumi, Funao Haruki, Nojiri Kenya, Suzuki Satoshi, Okada Eijiro, Ueda Seiji, Hikata Tomohiro, Shiono Yuta, Watanabe Kota, Watanabe Kei, Kaito Takashi, Yamashita Tomoya, Fujiwara Hiroyasu, Nagamoto Yukitaka, Terai Hidetomi, Tamai Koji, Matsuoka Yuji, Suzuki Hidekazu, Nishimura Hirosuke, Tagami Atsushi, Yamada Shuta, Adachi Shinji, Ohtori Seiji, Orita Sumihisa, Furuya Takeo, Yoshii Toshitaka, Ushio Shuta, Inoue Gen, Miyagi Masayuki, Saito Wataru, Imagama Shiro, Ando Kei, Sakai Daisuke, Nukaga Tadashi, Kiyasu Katsuhito, Kimura Atsushi, Inoue Hirokazu, Nakano Atsushi, Harimaya Katsumi, Kawaguchi Kenichi, Yokoyama Nobuhiko, Oishi Hidekazu, Doi Toshiro, Ikegami Shota, Shimizu Masayuki, Futatsugi Toshimasa, Kakutani Kenichiro, Yurube Takashi, Oshima Masashi, Uei Hiroshi, Aoki Yasuchika, Takahata Masahiko, Iwata Akira, Seki Shoji, Murakami Hideki, Yoshioka Katsuhito, Endo Hirooki, Hongo Michio, Nakanishi Kazuyoshi, Abe Tetsuya, Tsukanishi Toshinori, Ishii Ken

Spine Surgery and Related Research 4 ( 3 ) 199 - 207 2020（ eISSN:2432261X ）

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Introduction: Osteoporotic vertebral fracture (OVF) is the most common osteoporotic fracture, and some patients require surgical intervention to improve their impaired activities of daily living with neurological deficits. However, many previous reports have focused on OVF around the thoracolumbar junction, and the surgical outcomes of lumbar OVF have not been thoroughly discussed. We aimed to investigate the surgical outcomes for lumbar OVF with a neurological deficit.Methods: Patients who underwent fusion surgery for thoracolumbar OVF with a neurological deficit were enrolled at 28 institutions. Clinical information, comorbidities, perioperative complications, Japanese Orthopaedic Association scores, visual analog scale scores, and radiographic parameters were compared between patients with lower lumbar fracture (L3-5) and those with thoracolumbar junction fracture (T10-L2). Each patient with lower lumbar fracture (L group) was matched with to patients with thoracolumbar junction fracture (T group).Results: A total 403 patients (89 males and 314 females, mean age: 73.8 ± 7.8 years, mean follow-up: 3.9 ± 1.7 years) were included in this study. Lower lumbar OVF was frequently found in patients with lower bone mineral density. After matching, mechanical failure was more frequent in the L group (L group: 64%, T group: 39%; p < 0.001). There was no difference between groups in the clinical and radiographical outcomes, although the rates of complication and revision surgery were still high in both groups.Conclusions: The surgical intervention for OVF is effective in patients with myelopathy or radiculopathy regardless of the surgical level, although further study is required to improve clinical and radiographical outcomes.Level of evidence: Level III

DOI： 10.22603/ssrr.2019-0079

PubMed

CiNii Research
Reply to the Editor: Surgical Treatment of Osteoporotic Vertebral Fracture with Neurological Deficit-A Nationwide Multicenter Study in Japan

Hosogane Naobumi, Nojiri Kenya, Suzuki Satoshi, Funao Haruki, Okada Eijiro, Isogai Norihiro, Ueda Seiji, Hikata Tomohiro, Shiono Yuta, Watanabe Kota, Watanabe Kei, Kaito Takashi, Yamashita Tomoya, Fujiwara Hiroyasu, Nagamoto Yukitaka, Terai Hidetomi, Tamai Koji, Matsuoka Yuji, Suzuki Hidekazu, Nishimura Hirosuke, Tagami Atsushi, Yamada Syuta, Adachi Shinji, Ohtori Seiji, Orita Sumihisa, Furuya Takeo, Yoshii Toshitaka, Ushio Shuta, Inoue Gen, Miyagi Masayuki, Saito Wataru, Imagama Shiro, Ando Kei, Sakai Daisuke, Nukaga Tadashi, Kiyasu Katsuhito, Kimura Atsushi, Inoue Hirokazu, Nakano Atsushi, Harimaya Katsumi, Kawaguchi Kenichi, Yokoyama Nobuhiko, Oishi Hidekazu, Doi Toshio, Ikegami Shota, Shimizu Masayuki, Futatsugi Toshimasa, Kakutani Kenichiro, Yurube Takashi, Oshima Masashi, Uei Hiroshi, Aoki Yasuchika, Takahata Masahiko, Iwata Akira, Seki Shoji, Murakami Hideki, Yoshioka Katsuhito, Endo Hirooki, Hongo Michio, Nakanishi Kazuyoshi, Abe Tetsuya, Tsukanishi Toshinori, Ishii Ken

Spine Surgery and Related Research 4 ( 3 ) 292 - 293 2020（ eISSN:2432261X ）

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DOI： 10.22603/ssrr.2020-0033

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CiNii Research
Characteristic radiological findings for revision surgery after balloon kyphoplasty.

Takahashi S, Hoshino M, Yasuda H, Hori Y, Ohyama S, Terai H, Hayashi K, Tsujio T, Kono H, Suzuki A, Tamai K, Toyoda H, Dohzono S, Sasaoka R, Kanematsu F, Terakawa M, Nakamura H

Scientific reports 9 ( 1 ) 18513 2019.12

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DOI： 10.1038/s41598-019-55054-5

PubMed
Impact of Sarcopenia on Clinical Outcomes of Minimally Invasive Lumbar Decompression Surgery.

Toyoda H, Hoshino M, Ohyama S, Terai H, Suzuki A, Yamada K, Takahashi S, Hayashi K, Tamai K, Hori Y, Nakamura H

Scientific reports 9 ( 1 ) 16619 2019.11

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DOI： 10.1038/s41598-019-53053-0

PubMed
Surgical outcomes of spinal fusion for osteoporotic vertebral fracture in the thoracolumbar spine: Comprehensive evaluations of 5 typical surgical fusion techniques.

Watanabe K, Katsumi K, Ohashi M, Shibuya Y, Hirano T, Endo N, Kaito T, Yamashita T, Fujiwara H, Nagamoto Y, Matsuoka Y, Suzuki H, Nishimura H, Terai H, Tamai K, Tagami A, Yamada S, Adachi S, Yoshii T, Ushio S, Harimaya K, Kawaguchi K, Yokoyama N, Oishi H, Doi T, Kimura A, Inoue H, Inoue G, Miyagi M, Saito W, Nakano A, Sakai D, Nukaga T, Ikegami S, Shimizu M, Futatsugi T, Ohtori S, Furuya T, Orita S, Imagama S, Ando K, Kobayashi K, Kiyasu K, Murakami H, Yoshioka K, Seki S, Hongo M, Kakutani K, Yurube T, Aoki Y, Oshima M, Takahata M, Iwata A, Endo H, Abe T, Tsukanishi T, Nakanishi K, Watanabe K, Hikata T, Suzuki S, Isogai N, Okada E, Funao H, Ueda S, Shiono Y, Nojiri K, Hosogane N, Ishii K

Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association 24 ( 6 ) 1020 - 1026 2019.11（ ISSN:0949-2658 ）

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DOI： 10.1016/j.jos.2019.07.018

PubMed
Complications after spinal fixation surgery for osteoporotic vertebral collapse with neurological deficits: Japan Association of Spine Surgeons with ambition multicenter study.

Sakai Y, Kaito T, Takenaka S, Yamashita T, Makino T, Hosogane N, Nojiri K, Suzuki S, Okada E, Watanabe K, Funao H, Isogai N, Ueda S, Hikata T, Shiono Y, Watanabe K, Katsumi K, Fujiwara H, Nagamoto Y, Terai H, Tamai K, Matsuoka Y, Suzuki H, Nishimura H, Tagami A, Yamada S, Adachi S, Ohtori S, Orita S, Furuya T, Yoshii T, Ushio S, Inoue G, Miyagi M, Saito W, Imagama S, Ando K, Sakai D, Nukaga T, Kiyasu K, Kimura A, Inoue H, Nakano A, Harimaya K, Doi T, Kawaguchi K, Yokoyama N, Oishi H, Ikegami S, Futatsugi T, Shimizu M, Kakutani K, Yurube T, Oshima M, Uei H, Aoki Y, Takahata M, Iwata A, Seki S, Murakami H, Yoshioka K, Endo H, Hongo M, Nakanishi K, Abe T, Tsukanishi T, Ishii K

Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association 24 ( 6 ) 985 - 990 2019.11（ ISSN:0949-2658 ）

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DOI： 10.1016/j.jos.2019.08.015

PubMed
Fibroblast Growth Factor 9 Is Upregulated Upon Intervertebral Mechanical Stress-Induced Ligamentum Flavum Hypertrophy in a Rabbit Model.

Hayashi K, Suzuki A, Terai H, Ahmadi SA, Rahmani MS, Maruf MH, Habibi H, Hori Y, Yamada K, Hoshino M, Toyoda H, Takahashi S, Tamai K, Ohyama S, Imai Y, Nakamura H

Spine 44 ( 20 ) E1172 - E1180 2019.10（ ISSN:0362-2436 ）

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DOI： 10.1097/BRS.0000000000003089

PubMed
The most appropriate cervical vertebra for the measurement of occipitocervical inclination parameter: a validation study of C3, C4, and C5 levels using multi-positional magnetic resonance imaging.

Paholpak P, Formanek B, Vega A, Tamai K, Buser Z, Wang JC

European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society 28 ( 10 ) 2325 - 2332 2019.10（ ISSN:0940-6719 ）

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DOI： 10.1007/s00586-019-06028-8

PubMed
Increased advanced glycation end products in hypertrophied ligamentum flavum of diabetes mellitus patients.

Maruf MH, Suzuki A, Hayashi K, Habibi H, Salimi H, Terai H, Tamai K, Hoshino M, Toyoda H, Yamada K, Takahashi S, Ohyama S, Hori Y, Nakamura H

The spine journal : official journal of the North American Spine Society 19 ( 10 ) 1739 - 1745 2019.10（ ISSN:1529-9430 ）

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DOI： 10.1016/j.spinee.2019.06.001

PubMed
Sarcopenia is related to spinal sagittal imbalance in patients with spinopelvic mismatch.

Ohyama S, Hoshino M, Terai H, Toyoda H, Suzuki A, Takahashi S, Hayashi K, Tamai K, Hori Y, Nakamura H

European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society 28 ( 9 ) 1929 - 1936 2019.09（ ISSN:0940-6719 ）

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DOI： 10.1007/s00586-019-06066-2

PubMed
Development of a scoring system for predicting adjacent vertebral fracture after balloon kyphoplasty.

Takahashi S, Hoshino M, Yasuda H, Hori Y, Ohyama S, Terai H, Hayashi K, Tsujio T, Kono H, Suzuki A, Tamai K, Toyoda H, Dohzono S, Sasaoka R, Kanematsu F, Nakamura H

The spine journal : official journal of the North American Spine Society 19 ( 7 ) 1194 - 1201 2019.07（ ISSN:1529-9430 ）

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DOI： 10.1016/j.spinee.2019.02.013

PubMed
The Impact of Cervical Spinal Muscle Degeneration on Cervical Sagittal Balance and Spinal Degenerative Disorders.

Tamai K, Grisdela P Jr, Romanu J, Paholpak P, Nakamura H, Wang JC, Buser Z

Clinical spine surgery 32 ( 4 ) E206 - E213 2019.05（ ISSN:2380-0186 ）

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DOI： 10.1097/BSD.0000000000000789

PubMed
Answer to the Letter to the Editor concerning "The association of back muscle strength and sarcopenia-related parameters in the patients with spinal disorders" by Toyoda H, et al. (Eur Spine J; doi.org/10.1007/s00586-018-5858-8).

Toyoda H, Hoshino M, Ohyama S, Terai H, Suzuki A, Yamada K, Takahashi S, Hayashi K, Tamai K, Hori Y, Nakamura H

European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society 28 ( 5 ) 1252 - 1253 2019.05（ ISSN:0940-6719 ）

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DOI： 10.1007/s00586-019-05942-1

PubMed
Kinematic characteristics of patients with cervical imbalance: a weight-bearing dynamic MRI study.

Tamai K, Grisdela P Jr, Romanu J, Paholpak P, Buser Z, Wang JC

European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society 28 ( 5 ) 1200 - 1208 2019.05（ ISSN:0940-6719 ）

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DOI： 10.1007/s00586-018-05874-2

PubMed
Risk Factors for Proximal Junctional Fracture Following Fusion Surgery for Osteoporotic Vertebral Collapse with Delayed Neurological Deficits: A Retrospective Cohort Study of 403 Patients.

Tamai K, Terai H, Suzuki A, Nakamura H, Watanabe K, Katsumi K, Ohashi M, Shibuya Y, Izumi T, Hirano T, Kaito T, Yamashita T, Fujiwara H, Nagamoto Y, Matsuoka Y, Suzuki H, Nishimura H, Tagami A, Yamada S, Adachi S, Yoshii T, Ushio S, Harimaya K, Kawaguchi K, Yokoyama N, Oishi H, Doi T, Kimura A, Inoue H, Inoue G, Miyagi M, Saito W, Nakano A, Sakai D, Nukaga T, Ikegami S, Shimizu M, Futatsugi T, Ohtori S, Furuya T, Orita S, Imagama S, Ando K, Kobayashi K, Kiyasu K, Murakami H, Yoshioka K, Seki S, Hongo M, Kakutani K, Yurube T, Aoki Y, Oshima M, Takahata M, Iwata A, Endo H, Abe T, Tsukanishi T, Nakanishi K, Watanabe K, Hikata T, Suzuki S, Isogai N, Okada E, Funao H, Ueda S, Shiono Y, Nojiri K, Hosogane N, Ishii K

Spine surgery and related research 3 ( 2 ) 171 - 177 2019.04

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DOI： 10.22603/ssrr.2018-0068

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Impact of Hemodialysis on Surgical Outcomes and Mortality Rate after Lumbar Spine Surgery: A Matched Cohort Study.

Hori Y, Takahashi S, Terai H, Hoshino M, Toyoda H, Suzuki A, Hayashi K, Tamai K, Ohyama S, Nakamura H

Spine surgery and related research 3 ( 2 ) 151 - 156 2019.04

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DOI： 10.22603/ssrr.2018-0025

PubMed
Reliability and Validity of the AOSpine Thoracolumbar Injury Classification System: A Systematic Review.

Abedi A, Mokkink LB, Zadegan SA, Paholpak P, Tamai K, Wang JC, Buser Z

Global spine journal 9 ( 2 ) 231 - 242 2019.04（ ISSN:2192-5682 ）

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DOI： 10.1177/2192568218806847

PubMed
Kinematic evaluation of thoracic spinal cord sagittal diameter and the space available for cord using weight-bearing kinematic magnetic resonance imaging.

Paholpak P, Abedi A, Chamnan R, Chantarasirirat K, Tamai K, Buser Z, Wang JC

Spinal cord 57 ( 4 ) 276 - 281 2019.04（ ISSN:1362-4393 ）

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DOI： 10.1038/s41393-018-0198-4

PubMed
Prevention of Nerve Root Thermal Injury Caused by Bipolar Cauterization Near the Nerve Roots.

Ohyama S, Takahashi S, Tamai K, Hori Y, Hirakawa Y, Hoshino M, Suzuki A, Nakamura H

Spine 44 ( 6 ) E321 - E328 2019.03（ ISSN:0362-2436 ）

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DOI： 10.1097/BRS.0000000000002846

PubMed
Surgical outcomes of spinal fusion for osteoporotic thoracolumbar vertebral fractures in patients with Parkinson's disease: what is the impact of Parkinson's disease on surgical outcome?

Watanabe K, Katsumi K, Ohashi M, Shibuya Y, Izumi T, Hirano T, Endo N, Kaito T, Yamashita T, Fujiwara H, Nagamoto Y, Matsuoka Y, Suzuki H, Nishimura H, Terai H, Tamai K, Tagami A, Yamada S, Adachi S, Yoshii T, Ushio S, Harimaya K, Kawaguchi K, Yokoyama N, Oishi H, Doi T, Kimura A, Inoue H, Inoue G, Miyagi M, Saito W, Nakano A, Sakai D, Nukaga T, Ikegami S, Shimizu M, Futatsugi T, Ohtori S, Furuya T, Orita S, Imagama S, Ando K, Kobayashi K, Kiyasu K, Murakami H, Yoshioka K, Seki S, Hongo M, Kakutani K, Yurube T, Aoki Y, Oshima M, Takahata M, Iwata A, Endo H, Abe T, Tsukanishi T, Nakanishi K, Watanabe K, Hikata T, Suzuki S, Isogai N, Okada E, Funao H, Ueda S, Shiono Y, Nojiri K, Hosogane N, Ishii K

BMC musculoskeletal disorders 20 ( 1 ) 103 2019.03

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DOI： 10.1186/s12891-019-2473-8

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Cost-effectiveness of Balloon Kyphoplasty for Patients With Acute/Subacute Osteoporotic Vertebral Fractures in the Super-Aging Japanese Society.

Takahashi S, Hoshino M, Yasuda H, Terai H, Hayashi K, Tsujio T, Kono H, Suzuki A, Tamai K, Ohyama S, Toyoda H, Dohzono S, Kanematsu F, Hori Y, Nakamura H

Spine 44 ( 5 ) E298 - E305 2019.03（ ISSN:0362-2436 ）

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DOI： 10.1097/BRS.0000000000002829

PubMed
Perioperative Catheter Use as a Risk Factor for Surgical Site Infection After Cervical Surgery: An Analysis of 39,893 Patients.

Tamai K, Wang C, Heindel P, Paholpak P, Buser Z, Wang JC

Spine 44 ( 3 ) E157 - E161 2019.02（ ISSN:0362-2436 ）

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DOI： 10.1097/BRS.0000000000002790

PubMed
The association of back muscle strength and sarcopenia-related parameters in the patients with spinal disorders.

Toyoda H, Hoshino M, Ohyama S, Terai H, Suzuki A, Yamada K, Takahashi S, Hayashi K, Tamai K, Hori Y, Nakamura H

European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society 28 ( 2 ) 241 - 249 2019.02（ ISSN:0940-6719 ）

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DOI： 10.1007/s00586-018-5858-8

PubMed
Preoperative severity of facet joint degeneration does not impact the 2-year clinical outcomes and cervical imbalance following laminoplasty.

Tamai K, Suzuki A, Yabu A, Takahashi S, Toyoda H, Hoshino M, Terai H, Nakamura H

The spine journal : official journal of the North American Spine Society 19 ( 2 ) 246 - 252 2019.02（ ISSN:1529-9430 ）

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DOI： 10.1016/j.spinee.2018.06.343

PubMed
Balloon Kyphoplasty Versus Conservative Treatment for Acute Osteoporotic Vertebral Fractures With Poor Prognostic Factors: Propensity Score Matched Analysis Using Data From Two Prospective Multicenter Studies.

Hoshino M, Takahashi S, Yasuda H, Terai H, Watanabe K, Hayashi K, Tsujio T, Kono H, Suzuki A, Tamai K, Ohyama S, Toyoda H, Dohzono S, Kanematsu F, Hori Y, Nakamura H

Spine 44 ( 2 ) 110 - 117 2019.01（ ISSN:0362-2436 ）

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DOI： 10.1097/BRS.0000000000002769

PubMed
Evaluation of foraminal cross-sectional area in lumbar spondylolisthesis using kinematic MRI.

Paholpak P, Nazareth A, Khan YA, Khan SU, Ansari F, Tamai K, Buser Z, Wang JC

European journal of orthopaedic surgery & traumatology : orthopedie traumatologie 29 ( 1 ) 17 - 23 2019.01（ ISSN:1633-8065 ）

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DOI： 10.1007/s00590-018-2276-x

PubMed
Anatomical analysis of the human ligamentum flavum in the thoracic spine: Clinical implications for posterior thoracic spinal surgery.

Ahmadi SA, Suzuki A, Terai H, Tamai K, Akhgar J, Hoshino M, Toyoda H, Rahmani MS, Hayashi K, Ohyama S, Takahashi S, Nakamura H

Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association 24 ( 1 ) 62 - 67 2019.01（ ISSN:0949-2658 ）

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DOI： 10.1016/j.jos.2018.08.023

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Surgical Treatment of Osteoporotic Vertebral Fracture with Neurological Deficit-A Nationwide Multicenter Study in Japan.

Hosogane N, Nojiri K, Suzuki S, Funao H, Okada E, Isogai N, Ueda S, Hikata T, Shiono Y, Watanabe K, Watanabe K, Kaito T, Yamashita T, Fujiwara H, Nagamoto Y, Terai H, Tamai K, Matsuoka Y, Suzuki H, Nishimura H, Tagami A, Yamada S, Adachi S, Ohtori S, Orita S, Furuya T, Yoshii T, Ushio S, Inoue G, Miyagi M, Saito W, Imagama S, Ando K, Sakai D, Nukaga T, Kiyasu K, Kimura A, Inoue H, Nakano A, Harimaya K, Kawaguchi K, Yokoyama N, Oishi H, Doi T, Ikegami S, Shimizu M, Futatsugi T, Kakutani K, Yurube T, Oshima M, Uei H, Aoki Y, Takahata M, Iwata A, Seki S, Murakami H, Yoshioka K, Endo H, Hongo M, Nakanishi K, Abe T, Tsukanishi T, Ishii K

Spine surgery and related research 3 ( 4 ) 361 - 367 2019

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DOI： 10.22603/ssrr.2019-0004

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Comparison of minimally invasive decompression and combined minimally invasive decompression and fusion in patients with degenerative spondylolisthesis with instability.

Hayashi K, Toyoda H, Terai H, Hoshino M, Suzuki A, Takahashi S, Tamai K, Ohyama S, Hori Y, Yabu A, Nakamura H

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 57 79 - 85 2018.11（ ISSN:0967-5868 ）

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DOI： 10.1016/j.jocn.2018.08.032

PubMed
Small C7-T1 lordotic angle and muscle degeneration at C7 level were independent radiological characteristics of patients with cervical imbalance: a propensity score-matched analysis.

Tamai K, Romanu J, Grisdela P Jr, Paholpak P, Zheng P, Nakamura H, Buser Z, Wang JC

The spine journal : official journal of the North American Spine Society 18 ( 9 ) 1505 - 1512 2018.09（ ISSN:1529-9430 ）

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DOI： 10.1016/j.spinee.2018.01.012

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The evaluation of lumbar paraspinal muscle quantity and quality using the Goutallier classification and lumbar indentation value.

Tamai K, Chen J, Stone M, Arakelyan A, Paholpak P, Nakamura H, Buser Z, Wang JC

European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society 27 ( 5 ) 1005 - 1012 2018.05（ ISSN:0940-6719 ）

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DOI： 10.1007/s00586-018-5485-4

PubMed
Can multi-positional magnetic resonance imaging be used to evaluate angular parameters in cervical spine? A comparison of multi-positional MRI to dynamic plain radiograph.

Paholpak P, Tamai K, Shoell K, Sessumpun K, Buser Z, Wang JC

European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society 27 ( 5 ) 1021 - 1027 2018.05（ ISSN:0940-6719 ）

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DOI： 10.1007/s00586-017-5306-1

PubMed
Characteristics of Cervical Spine Motion in Different Types of Cervical Alignment: Kinematic MRI Study.

Sessumpun K, Paholpak P, Hindoyan KN, Tamai K, Sangkomkamhang T, Buser Z, Wang JC

Clinical spine surgery 31 ( 4 ) E239 - E244 2018.05（ ISSN:2380-0186 ）

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DOI： 10.1097/BSD.0000000000000605

PubMed
MRI kinematic analysis of T1 sagittal motion between cervical flexion and extension positions in 145 patients.

Tamai K, Buser Z, Paholpak P, Sessumpun K, Hsieh PC, Nakamura H, Wang JC

European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society 27 ( 5 ) 1034 - 1041 2018.05（ ISSN:0940-6719 ）

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DOI： 10.1007/s00586-017-5385-z

PubMed
Can C7 Slope Substitute the T1 slope?: An Analysis Using Cervical Radiographs and Kinematic MRIs.

Tamai K, Buser Z, Paholpak P, Sessumpun K, Nakamura H, Wang JC

Spine 43 ( 7 ) 520 - 525 2018.04（ ISSN:0362-2436 ）

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DOI： 10.1097/BRS.0000000000002371

PubMed
Validity and Reproducibility of Various Measurement Methods for Craniocervical Sagittal Balance.

Tamai K, Suzuki A, Takahashi S, Hoshino M, Toyoda H, Hayashi K, Ohyama S, Kishimura Y, Onode E, Umano M, Terai H, Nakamura H

Clinical spine surgery 31 ( 2 ) 80 - 85 2018.03（ ISSN:2380-0186 ）

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DOI： 10.1097/BSD.0000000000000617

PubMed
Predictive factors for osteochondritis dissecans of the lateral femoral condyle concurrent with a discoid lateral meniscus.

Takigami J, Hashimoto Y, Tomihara T, Yamasaki S, Tamai K, Kondo K, Nakamura H

Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA 26 ( 3 ) 799 - 805 2018.03（ ISSN:0942-2056 ）

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DOI： 10.1007/s00167-017-4451-8

PubMed
The primary diagnosis and the coexisting anxiety disorders have no impact on the additional surgical procedure after spinal cord stimulators implantation: An analysis of 11,029 patients.

Tamai K, Buser Z, Wang C, Paholpak P, Nakamura H, Wang JC, Hsieh PC

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 47 208 - 213 2018.01（ ISSN:0967-5868 ）

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DOI： 10.1016/j.jocn.2017.10.016

PubMed
Differences in short-term clinical and radiological outcomes depending on timing of balloon kyphoplasty for painful osteoporotic vertebral fracture.

Takahashi S, Hoshino M, Terai H, Toyoda H, Suzuki A, Tamai K, Watanabe K, Tsujio T, Yasuda H, Kono H, Sasaoka R, Dohzono S, Hayashi K, Ohyama S, Hori Y, Nakamura H

Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association 23 ( 1 ) 51 - 56 2018.01（ ISSN:0949-2658 ）

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DOI： 10.1016/j.jos.2017.09.019

PubMed
Anatomical analysis of human ligamentum flavum in the cervical spine: Special consideration to the attachments, coverage, and lateral extent.

Rahmani MS, Terai H, Akhgar J, Suzuki A, Toyoda H, Hoshino M, Tamai K, Ahmadi SA, Hayashi K, Takahashi S, Nakamura H

Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association 22 ( 6 ) 994 - 1000 2017.11（ ISSN:0949-2658 ）

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DOI： 10.1016/j.jos.2017.07.008

PubMed
Mechanical stress induces elastic fibre disruption and cartilage matrix increase in ligamentum flavum.

Hayashi K, Suzuki A, Abdullah Ahmadi S, Terai H, Yamada K, Hoshino M, Toyoda H, Takahashi S, Tamai K, Ohyama S, Javid A, Suhrab Rahmani M, Hasib MM, Nakamura H

Scientific reports 7 ( 1 ) 13092 2017.10

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DOI： 10.1038/s41598-017-13360-w

PubMed
Complications Associated With Spine Surgery in Patients Aged 80 Years or Older: Japan Association of Spine Surgeons with Ambition (JASA) Multicenter Study.

Kobayashi K, Imagama S, Ando K, Ishiguro N, Yamashita M, Eguchi Y, Matsumoto M, Ishii K, Hikata T, Seki S, Terai H, Suzuki A, Tamai K, Aramomi M, Ishikawa T, Kimura A, Inoue H, Inoue G, Miyagi M, Saito W, Yamada K, Hongo M, Nishimura H, Suzuki H, Nakano A, Watanabe K, Chikuda H, Ohya J, Aoki Y, Shimizu M, Futatsugi T, Mukaiyama K, Hasegawa M, Kiyasu K, Iizuka H, Iizuka Y, Kobayashi R, Nishida K, Kakutani K, Nakajima H, Murakami H, Demura S, Kato S, Yoshioka K, Namikawa T, Watanabe K, Nakanishi K, Nakagawa Y, Yoshimoto M, Fujiwara H, Nishida N, Imajo Y, Yamazaki M, Sakane M, Abe T, Fujii K, Kaito T, Furuya T, Orita S, Ohtori S

Global spine journal 7 ( 7 ) 636 - 641 2017.10（ ISSN:2192-5682 ）

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DOI： 10.1177/2192568217716144

PubMed
Risk Factors for Delirium After Spine Surgery in Extremely Elderly Patients Aged 80 Years or Older and Review of the Literature: Japan Association of Spine Surgeons with Ambition Multicenter Study.

Kobayashi K, Imagama S, Ando K, Ishiguro N, Yamashita M, Eguchi Y, Matsumoto M, Ishii K, Hikata T, Seki S, Terai H, Suzuki A, Tamai K, Aramomi M, Ishikawa T, Kimura A, Inoue H, Inoue G, Miyagi M, Saito W, Yamada K, Hongo M, Matsuoka Y, Suzuki H, Nakano A, Watanabe K, Chikuda H, Ohya J, Aoki Y, Shimizu M, Futatsugi T, Mukaiyama K, Hasegawa M, Kiyasu K, Iizuka H, Iizuka Y, Kobayashi R, Nishida K, Kakutani K, Nakajima H, Murakami H, Demura S, Kato S, Yoshioka K, Namikawa T, Watanabe K, Nakanishi K, Nakagawa Y, Yoshimoto M, Fujiwara H, Nishida N, Imajo Y, Yamazaki M, Sakane M, Abe T, Fujii K, Kaito T, Furuya T, Orita S, Ohtori S

Global spine journal 7 ( 6 ) 560 - 566 2017.09（ ISSN:2192-5682 ）

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DOI： 10.1177/2192568217700115

PubMed
Incidence of Pleural Fluid and Its Associated Risk Factors After Posterior Spinal Fusion in Patients With Adolescent Idiopathic Scoliosis.

Hayashi K, Terai H, Toyoda H, Suzuki A, Hoshino M, Tamai K, Ohyama S, Nakamura H

Spine 42 ( 8 ) 603 - 609 2017.04（ ISSN:0362-2436 ）

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DOI： 10.1097/BRS.0000000000001861

PubMed
Anterior Cervical Discectomy and Fusion Provides Better Surgical Outcomes Than Posterior Laminoplasty in Elderly Patients With C3-4 Level Myelopathy.

Tamai K, Terai H, Suzuki A, Toyoda H, Hoshino M, Takahashi S, Hayashi K, Ohyama S, Nakamura H

Spine 42 ( 8 ) 548 - 555 2017.04（ ISSN:0362-2436 ）

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DOI： 10.1097/BRS.0000000000001874

PubMed
The incidence of nerve root injury by high-speed drill can be reduced by chilled saline irrigation in a rabbit model.

Tamai K, Suzuki A, Takahashi S, Akhgar J, Rahmani MS, Hayashi K, Ohyama S, Nakamura H

The bone & joint journal 99-B ( 4 ) 554 - 560 2017.04（ ISSN:2049-4394 ）

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DOI： 10.1302/0301-620X.99B4.BJJ-2016-0841.R1

PubMed
Cervical lordotic alignment following posterior spinal fusion for adolescent idiopathic scoliosis: reciprocal changes and risk factors for malalignment.

Hayashi K, Toyoda H, Terai H, Suzuki A, Hoshino M, Tamai K, Ohyama S, Nakamura H

Journal of neurosurgery. Pediatrics 19 ( 4 ) 440 - 447 2017.04（ ISSN:1933-0707 ）

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DOI： 10.3171/2016.9.PEDS16298

PubMed
Anatomical analysis of the relation between human ligamentum flavum and posterior spinal bony prominence.

Akhgar J, Terai H, Rahmani MS, Tamai K, Suzuki A, Toyoda H, Hoshino M, Ikebuchi M, Ahmadi SA, Hayashi K, Nakamura H

Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association 22 ( 2 ) 260 - 265 2017.03（ ISSN:0949-2658 ）

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DOI： 10.1016/j.jos.2016.11.020

PubMed
Facet Effusion without Radiographic Instability Has No Effect on the Outcome of Minimally Invasive Decompression Surgery.

Tamai K, Kato M, Konishi S, Matsumura A, Hayashi K, Nakamura H

Global spine journal 7 ( 1 ) 21 - 27 2017.02（ ISSN:2192-5682 ）

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DOI： 10.1055/s-0036-1583173

PubMed
Risk factors of cervical surgery related complications in patients older than 80 years.

Tamai K, Terai H, Suzuki A, Nakamura H, Yamashita M, Eguchi Y, Imagama S, Ando K, Kobayashi K, Matsumoto M, Ishii K, Hikata T, Seki S, Aramomi M, Ishikawa T, Kimura A, Inoue H, Inoue G, Miyagi M, Saito W, Yamada K, Hongo M, Endo K, Suzuki H, Nakano A, Watanabe K, Ohya J, Chikuda H, Aoki Y, Shimizu M, Futatsugi T, Mukaiyama K, Hasegawa M, Kiyasu K, Iizuka H, Nishida K, Kakutani K, Nakajima H, Murakami H, Demura S, Kato S, Yoshioka K, Namikawa T, Watanabe K, Nakanishi K, Nakagawa Y, Yoshimoto M, Fujiwara H, Nishida N, Sakane M, Yamazaki M, Kaito T, Furuya T, Orita S, Ohtori S

Spine surgery and related research 1 ( 4 ) 179 - 184 2017

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DOI： 10.22603/ssrr.1.2017-0002

PubMed
Clinical Outcome of Cervical Laminoplasty and Postoperative Radiological Change for Cervical Myelopathy With Degenerative Spondylolisthesis.

Suzuki A, Tamai K, Terai H, Hoshino M, Toyoda H, Takahashi S, Hayashi K, Ohyama S, Nakamura H

Spine 41 ( 23 ) 1808 - 1812 2016.12（ ISSN:0362-2436 ）

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DOI： 10.1097/BRS.0000000000001706

PubMed
Laminar closure after expansive open-door laminoplasty: fixation methods and cervical alignments impact on the laminar closure and surgical outcomes.

Tamai K, Suzuki A, Terai H, Toyoda H, Hoshino M, Nakamura H

The spine journal : official journal of the North American Spine Society 16 ( 9 ) 1062 - 9 2016.09（ ISSN:1529-9430 ）

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DOI： 10.1016/j.spinee.2016.04.018

PubMed
Anatomical Location of the Common Iliac Veins at the Level of the Sacrum: Relationship between Perforation Risk and the Trajectory Angle of the Screw.

Akhgar J, Terai H, Suhrab Rahmani M, Tamai K, Suzuki A, Toyoda H, Hoshino M, Abdullah Ahmadi S, Hayashi K, Nakamura H

BioMed research international 2016 1457219 2016（ ISSN:2314-6133 ）

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DOI： 10.1155/2016/1457219

PubMed
Which is the best schedule of autologous blood storage for preoperative adolescent idiopathic scoliosis patients?

Tamai K, Terai H, Toyoda H, Suzuki A, Yasuda H, Dozono S, Nakamura H

Scoliosis 10 ( Suppl 2 ) S11 2015（ ISSN:1748-7161 ）

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DOI： 10.1186/1748-7161-10-S2-S11

PubMed
A new corrective technique for adolescent idiopathic scoliosis: convex manipulation using 6.35 mm diameter pure titanium rod followed by concave fixation using 6.35 mm diameter titanium alloy.

Terai H, Toyoda H, Suzuki A, Dozono S, Yasuda H, Tamai K, Nakamura H

Scoliosis 10 ( Suppl 2 ) S14 2015（ ISSN:1748-7161 ）

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DOI： 10.1186/1748-7161-10-S2-S14

PubMed
The novel HECT-type ubiquitin-protein ligase Pub2p shares partially overlapping function with Pub1p in Schizosaccharomyces pombe.

Tamai KK, Shimoda C

Journal of cell science 115 ( Pt 9 ) 1847 - 57 2002.05（ ISSN:0021-9533 ）

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DOI： 10.1242/jcs.115.9.1847

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MISC

症候性多発性仙骨神経根嚢胞の診断と治療　テクニカルノート(Diagnosis and Treatment of Symptomatic Multiple Sacral Perineural Cysts-Technical Note)

Tsujino Masashi, Suzuki Akinobu, Terai Hidetomi, Kato Minori, Toyoda Hiromitsu, Takahashi Shinji, Tamai Koji, Nakamura Hiroaki

Spine Surgery and Related Research 9 ( 1 ) 93 - 99 2025.01
脊椎　若手医師のための経験すべき"領域別"手術講座(PART2)　頸椎症性脊髄症　椎管孔開窓術を必要とする症例

玉井孝司

整形外科Surgical Technique 14 ( 4 ) 485 - 493 2024.08（ ISSN:2185-7733 ）
骨粗鬆症性椎体骨折の保存加療における装具の効果

岩前真由, 高橋真治, 寺井秀富, 玉井孝司, 星野雅俊, 豊田宏光, 鈴木亨暢, 加藤相勲, 馬野雅之, 小林祐人, 佐々木亮, 上松正人, 島田永和, 中村博亮

Journal of Spine Research 15 ( 6 ) 869 - 876 2024.06（ ISSN:1884-7137 ）

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骨粗鬆症性椎体骨折は,最も頻度の高い骨粗鬆症骨折であり,患者のQOLやADLに影響を与える.椎体骨折の保存加療では,一般的に装具療法を選択することが多いが,現状そのエビデンスは乏しい.新鮮骨粗鬆症性椎体骨折に対しては装具治療を行うというのが一般常識化していることから,倫理的観点から装具を装着しない前向き研究は行うことが難しい.実際に装具の有無で装具の効果を検証した研究は極めて少ない.そこで我々は過去に装具なしのコホートと装具ありのコホートのデータを傾向スコアマッチングで比較し,装具の効果を検証した研究を実施した.本総説では過去の我々の研究も含めた装具に関する報告をもとに,OVFにおける装具の効果を総括したい.(著者抄録)
Improvement of AIS C spinal cord incomplete injury in elderly population

玉井孝司, 寺井秀富, 加藤仁志, 中島宏彰, 安部哲哉, 名越慈人, 古矢丈雄, 中嶋秀明, 長谷川智彦, 寺島嘉紀, 中村博亮

Journal of Spine Research (Web) 15 ( 3 ) 2024（ ISSN:2435-1563 ）

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J-GLOBAL

Presentations

転移性脊椎腫瘍における手術による疼痛の術後変化とADLに与える影響　JASA多施設共同研究

鈴木亨暢, 玉井孝司, 古矢丈雄, 加藤仁志, 角谷賢一朗, 冨永博之, 石原昌幸, 名越慈人, 船山徹, 井上玄, 寺井秀富

日本整形外科学会雑誌 2026.03 (公社)日本整形外科学会
体幹筋量の経年変化が腰痛と脊柱アライメントへ与える影響　前向きコホート研究

岡村悠貴, 高橋真治, 大山翔一朗, 堀悠介, 星野雅俊, 加藤相勲, 豊田宏光, 鈴木亨暢, 玉井孝司, 中村博亮, 寺井秀富

日本整形外科学会雑誌 2026.03 (公社)日本整形外科学会
腰痛の病態と治療　骨粗鬆症性椎体骨折における腰痛の病態とその特徴

高橋真治, 加藤相勲, 豊田宏光, 鈴木亨暢, 玉井孝司, 寺井秀富

中部日本整形外科災害外科学会雑誌 2025.10 (一社)中部日本整形外科災害外科学会
腰椎変性すべり症に対する手術療法の再検証　内視鏡下後方除圧術の臨床成績からみた腰椎変性すべり症に対する除圧術の適応

鈴木亨暢, 豊田宏光, 加藤相勲, 高橋真治, 玉井孝司, 寺井秀富

中部日本整形外科災害外科学会雑誌 2025.10 (一社)中部日本整形外科災害外科学会
骨粗鬆症診療におけるArtificial Intelligence(AI) update　骨粗鬆症診療におけるAIの臨床応用　主成分解析と深層学習による診断・予後予測の挑戦

谷脇浩志, 藪晋人, 高橋真治, 星野雅俊, 玉井孝司, 鈴木亨暢, 豊田宏光, 加藤相勲, 中村博亮, 寺井秀富

日本骨粗鬆症学会雑誌 2025.08 (一社)日本骨粗鬆症学会
骨粗鬆症患者の脊椎矯正固定術におけるロモソズマブの効果の検証

澤田雄大, 高橋真治, 安田宏之, 寺川雅基, 小西定彦, 加藤相勲, 豊田宏光, 鈴木亨暢, 玉井孝司, 寺井秀富

日本骨粗鬆症学会雑誌 2025.08 (一社)日本骨粗鬆症学会
頸髄症患者における自覚的な膀胱機能低下がQOLに及ぼす影響と術後QOLの改善

赤井靖明, 玉井孝司, 鈴木亨暢, 高橋真治, 中村博亮, 寺井秀富

中部日本整形外科災害外科学会雑誌 2025.04 (一社)中部日本整形外科災害外科学会
脊椎脊髄損傷治療に対する治療戦略　高齢頸髄損傷患者における低栄養状態が受傷後推移に及ぼす影響

玉井孝司, 鈴木亨暢, 岩前真由, 小林祐人, 寺井秀富

中部日本整形外科災害外科学会雑誌 2025.04 (一社)中部日本整形外科災害外科学会
内視鏡下椎弓切除術導入におけるラーニングカーブ　UBE/BESS vs MEL

赤井靖明, 加藤相勲, 鈴木亨暢, 高橋真治, 玉井孝司, 寺井秀富

中部日本整形外科災害外科学会雑誌 2025.04 (一社)中部日本整形外科災害外科学会
頸椎症性脊髄症術後に遺残する上肢しびれは治療満足度に影響する

玉井孝司, 寺井秀富, 加藤相勲, 鈴木亨暢, 高橋真治, 澤田雄大, 岩前真由, 岡村悠貴, 小林祐人, 中村博亮

日本整形外科学会雑誌 2025.03 (公社)日本整形外科学会
術前の頸椎伸展・屈曲可動域が頸椎椎弓形成術後の後彎変形および術後2年時までの臨床成績に及ぼす影響について

若狹柱燦, 玉井孝司, 寺井秀富, 鈴木亨暢, 加藤相勲, 豊田宏光, 高橋真治, 澤田雄大, 岩前真由, 岡村悠貴, 中村博亮

日本整形外科学会雑誌 2025.03 (公社)日本整形外科学会
燃焼式タバコが頸椎症性脊髄症術後に及ぼす影響　リアルワールドデータの解析

小林祐介, 玉井孝司, 岩前真由, 高橋真治, 寺井秀富, 加藤相勲, 豊田宏光, 鈴木亨暢, 澤田雄大, 岡村悠貴, 中村博亮

日本整形外科学会雑誌 2025.03 (公社)日本整形外科学会
セメント注入型椎弓根スクリューにおけるセメント漏出リスク因子と有効性について

上松正人, 高橋真治, 辻野正志, 佐々木亮, 玉井孝司, 鈴木亨暢, 豊田宏光, 加藤相勲, 百町貴彦, 中村博亮, 寺井秀富

日本整形外科学会雑誌 2025.03 (公社)日本整形外科学会
骨粗鬆症患者におけるセメント注入型椎弓根スクリューの有効性の検討　傾向スコアマッチング

上松正人, 高橋真治, 百町貴彦, 加藤相勲, 豊田宏光, 鈴木亨暢, 玉井孝司, 佐々木亮, 辻野正志, 中村博亮, 寺井秀富

Journal of Spine Research 2025.02 (一社)日本脊椎脊髄病学会
骨粗鬆症性椎体骨折に対する椎体置換術後のケージ沈下のリスク因子

木下右貴, 高橋真治, 玉井孝司, 鈴木亨暢, 豊田宏光, 加藤相勲, 澤田雄大, 岩前真由, 岡村悠貴, 小林祐人, 谷脇浩志, 上松正人

Journal of Spine Research 2025.02 (一社)日本脊椎脊髄病学会
頸髄症患者における自覚的な膀胱機能低下がQOLに及ぼす影響と術後QOLの改善

玉井孝司, 鈴木亨暢, 寺川雅基, 高橋真治, 小林祐人, 馬野雅之, 星野雅俊, 辻尾唯雄, 安田宏之, 岩前真由, 豊田宏光, 関昌彦, 加藤相勲, 中村博亮, 寺井秀富

Journal of Spine Research 2025.02 (一社)日本脊椎脊髄病学会
頸部傍脊柱筋脂肪変性・断面積は頸椎術後QOL改善と関連するか?

谷脇浩志, 玉井孝司, 鈴木亨暢, 寺川雅基, 高橋真治, 小林祐人, 馬野雅之, 星野雅俊, 辻尾唯雄, 安田宏之, 中村博亮, 寺井秀富

Journal of Spine Research 2025.02 (一社)日本脊椎脊髄病学会
頸椎神経根症に対する超音波ガイド下神経根ブロックの有効性　ランダム化比較試験

佐々木亮, 玉井孝司, 馬野雅之, 小林祐人, 上松正人, 岡誠, 勝田紘史, 島田永和, 中村博亮, 寺井秀富

Journal of Spine Research 2025.02 (一社)日本脊椎脊髄病学会
頸椎症性脊髄症術後と腰部脊柱管狭窄症術後の心理側面的QOLの改善　鍵は「社会生活機能」と「腰痛」

玉井孝司, 加藤相勲, 豊田宏光, 鈴木亨暢, 高橋真治, 藪晋人, 澤田雄大, 岩前真由, 小林祐人, 岡村悠貴, 谷脇浩志, 上松正人, 木下右貴, 中村博亮, 寺井秀富

Journal of Spine Research 2025.02 (一社)日本脊椎脊髄病学会
頸椎単純X線側面像から腰椎・大腿骨の骨量低下を検知する深層学習アルゴリズムの精度検証

玉井孝司, 寺川雅基, 上松正人, 加藤相勲, 豊田宏光, 鈴木亨暢, 高橋真治, 藪晋人, 岩前真由, 小林祐人, 岡村悠貴, 谷脇浩志, 木下右貴, 星野雅俊, 中村博亮, 寺井秀富

Journal of Spine Research 2025.02 (一社)日本脊椎脊髄病学会
転移性脊椎腫瘍に対する姑息的手術における術後合併症発生率とリスク因子の解析

岡村悠貴, 鈴木亨暢, 加藤相勲, 豊田宏光, 高橋真治, 玉井孝司, 藪晋人, 澤田雄大, 岩前真由, 小林祐人, 上松正人, 木下右貴, 谷脇浩志, 中村博亮, 寺井秀富

Journal of Spine Research 2025.02 (一社)日本脊椎脊髄病学会
転移性脊椎腫瘍における手術による疼痛の術後変化とADLに与える影響　JASA多施設共同研究

鈴木亨暢, 玉井孝司, 古矢丈雄, 加藤仁志, 角谷賢一朗, 冨永博之, 石原昌幸, 名越慈人, 船山徹, 井上泰一, 飯村拓哉, 中嶋秀明, 竹上徳彦, 中西一夫, 井上玄

Journal of Spine Research 2025.02 (一社)日本脊椎脊髄病学会
術前の頸椎伸展・屈曲可動域が頸椎椎弓形成術後の後彎変形および術後2年時までの臨床成績に及ぼす影響について

若狹柱燦, 玉井孝司, 鈴木亨暢, 加藤相勲, 豊田宏光, 高橋真治, 澤田雄大, 岩前真由, 岡村悠貴, 小林祐人, 谷脇浩志, 上松正人, 木下右貴, 中村博亮, 寺井秀富

Journal of Spine Research 2025.02 (一社)日本脊椎脊髄病学会
腰椎除圧術術後に発生する椎間板変性のリスク因子探索　除圧椎間と非除圧椎間との比較

豊田宏光, Habibi Hasibullah, 加藤相勲, 鈴木亨暢, 高橋真治, 玉井孝司, 岩前真由, 澤田雄大, 岡村悠貴, 小林祐人, 中村博亮, 寺井秀富

Journal of Spine Research 2025.02 (一社)日本脊椎脊髄病学会
腰椎椎間板ヘルニアに対するコンドリアーゼ椎間板内注入療法と低侵襲髄核摘出術の臨床成績比較　傾向スコアマッチングを用いた2群比較

上松正人, 玉井孝司, 加藤相勲, 豊田宏光, 鈴木亨暢, 高橋真治, 澤田雄大, 岩前真由, 岡村悠貴, 小林祐人, 谷脇浩志, 木下右貴, 中村博亮, 寺井秀富

Journal of Spine Research 2025.02 (一社)日本脊椎脊髄病学会
腰椎手術における骨粗鬆症評価　主成分解析を用いたHU値とVBQ scoreの骨主要因子および骨補助因子の検討

谷脇浩志, 高橋真治, 星野雅俊, 木下右貴, 松村昭, 並川崇, 加藤相勲, 鈴木亨暢, 豊田宏光, 玉井孝司, 藪晋人, 澤田雄大, 岩前真由, 中村博亮, 寺井秀富

Journal of Spine Research 2025.02 (一社)日本脊椎脊髄病学会
腰椎変性すべり症は内視鏡下椎弓切除術の成績不良リスクとなるか

岡誠, 金田国一, 玉井孝司, 勝田紘史, 島田永和, 寺井秀富

Journal of Spine Research 2025.02 (一社)日本脊椎脊髄病学会
脊髄腫瘍摘出術による疼痛の変化と疼痛遺残の危険因子

寺元皓太朗, 鈴木亨暢, 加藤相勳, 豊田宏光, 高橋真治, 玉井孝司, 澤田雄大, 岩前真由, 小林祐人, 岡村悠貴, 上松正人, 谷脇浩志, 中村博亮, 寺井秀富

Journal of Spine Research 2025.02 (一社)日本脊椎脊髄病学会
脊椎領域におけるAI　頸椎疾患領域におけるAIの進捗と実装への課題

玉井孝司, 鈴木亨暢, 加藤相勲, 豊田宏光, 高橋真治, 藪晋人, 澤田雄大, 岩前真由, 小林祐人, 岡村悠貴, 谷脇浩志, 上松正人, 木下右貴, 田淵仁志, 星野雅俊, 中村博亮, 寺井秀富

Journal of Spine Research 2025.02 (一社)日本脊椎脊髄病学会
脊椎矯正固定術におけるPJKに対するロモソズマブの効果

澤田雄大, 高橋真治, 安田宏之, 寺川雅基, 小西定彦, 加藤相勲, 豊田宏光, 鈴木亨暢, 玉井孝司, 岩前真由, 岡村悠貴, 小林祐人, 中村博亮, 寺井秀富

Journal of Spine Research 2025.02 (一社)日本脊椎脊髄病学会
脊椎ビッグデータ(レジストリー)　脊柱靱帯骨化症レジストリー症例登録の現状と今後の展望

高橋宏, 國府田正雄, 松山幸弘, 西田周泰, 高畑雅彦, 遠藤努, 吉井俊貴, 玉井孝司, 松本守雄, 中村雅也, 佐藤公昭, 川口善治, 竹下克志, 渡辺雅彦, 種市洋, 山崎正志

Journal of Spine Research 2025.02 (一社)日本脊椎脊髄病学会
片開き式頸椎椎弓形成の固定椎弓数削減法は全椎弓固定と比して非劣性である　SKIP-2　多施設ランダム化比較試験術後2年時結果

玉井孝司, 鈴木亨暢, 寺川雅基, 高橋真治, 小林祐人, 馬野雅之, 星野雅俊, 辻尾唯雄, 安田宏之, 岩前真由, 豊田宏光, 関昌彦, 加藤相勲, 中村博亮, 寺井秀富

Journal of Spine Research 2025.02 (一社)日本脊椎脊髄病学会
燃焼式タバコが頸椎症性脊髄症術後に及ぼす影響　多施設前向きコホート研究の解析

小林祐人, 玉井孝司, 岩前真由, 高橋真治, 加藤相勲, 豊田宏光, 鈴木亨暢, 澤田雄大, 岡村悠貴, 上松正人, 谷脇浩志, 木下右貴, 寺井秀富

Journal of Spine Research 2025.02 (一社)日本脊椎脊髄病学会
機械学習による骨粗鬆症性椎体骨折後の骨折予後予測

藪晋人, 高橋真治, 星野雅俊, 辻尾唯雄, 猪瀬弘之, 加藤剛, 加藤相勲, 豊田宏光, 鈴木亨暢, 玉井孝司, 吉井俊貴, 中村博亮, 寺井秀富

Journal of Spine Research 2025.02 (一社)日本脊椎脊髄病学会
従来型タバコおよび加熱式タバコエアロゾルが慢性頸髄圧迫ラットモデルにおける頸椎症性脊髄症に与える影響(Effect of combustible cigarettes and Heated Tobacco Products aerosol on cervical myelopathy in a rat model of chronic cervical spinal cord compression)

Kobayashi Yuto, Tamai Koji, Iwamae Masayoshi, Kato Minori, Toyoda Hiromitsu, Suzuki Akinobu, Sawada Yuta, Okamura Yuki, Uematsu Masato, Taniwaki Hiroshi, Kinoshita Yuki, Miura Masataka, Nagashima Yuki, Furuya Takeo, Terai Hidetomi

Journal of Spine Research 2025.02 (一社)日本脊椎脊髄病学会
BKP後の隣接椎体骨折リスク評価におけるCT Hounsfield Unit(HU)・MRI Vertebral Bone Quality(VBQ) scoreの有用性

谷脇浩志, 高橋真治, 星野雅俊, 堀悠介, 安田宏之, 辻尾唯雄, 大山翔一朗, 豊田宏光, 鈴木亨暢, 河野浩, 堂園将, 兼松文昭, 玉井孝司, 中村博亮, 寺井秀富

Journal of Spine Research 2025.02 (一社)日本脊椎脊髄病学会
JOABPEQを用いた高齢者腰椎変性疾患手術例の評価における最重要ドメインは?　minimally clinical important differenceの年代別検討に基づいて

加藤相勲, 豊田宏光, 鈴木亨暢, 高橋真治, 玉井孝司, 藪晋人, 澤田雄大, 岩前真由, 小林祐人, 岡村悠貴, 木下右貴, 谷脇浩志, 上松正人, 松村昭, 並川崇, 寺井秀富

Journal of Spine Research 2025.02 (一社)日本脊椎脊髄病学会
すべり・不安定性を有する頸椎症性脊髄症に対する後方除圧術単独と後方除圧固定術の比較検討

粕川雄司, 古矢丈雄, 中島宏彰, 森幹士, 中嶋秀明, 玉井孝司, 手束文威, 和田簡一郎, 宮腰尚久, 海渡貴司, 橋爪洋, 吉井俊貴, 日本脊椎脊髄病学会プロジェクト委員会

Journal of Spine Research 2025.02 (一社)日本脊椎脊髄病学会
セメント注入型椎弓根スクリューにおけるセメント漏出のリスク軽減に関する検討

上松正人, 高橋真治, 百町貴彦, 加藤相勲, 豊田宏光, 鈴木亨暢, 玉井孝司, 佐々木亮, 辻野正志, 中村博亮, 寺井秀富

Journal of Spine Research 2025.02 (一社)日本脊椎脊髄病学会
テリパラチド(週2回製剤)の腸腰筋,傍脊柱筋への効果の検討　傾向スコアマッチング検定

岩前真由, 高橋真治, 玉井孝司, 星野雅俊, 小林祐人, 馬野雅之, 佐々木亮, 上松正人, 加藤相勲, 豊田宏光, 鈴木亨暢, 勝田紘史, 島田永和, 中村博亮, 寺井秀富

Journal of Spine Research 2025.02 (一社)日本脊椎脊髄病学会
バルーン椎体形成術後に隣接椎体骨折を発症した患者の治療満足度(Treatment satisfaction of patients who suffered an adjacent vertebral fracture after balloon kyphoplasty)

Habibi Hasibullah, Tamai Koji, Iwamae Masayoshi, Katsuda Hiroshi, Shimada Nagakazu, Takahashi Shinji, Nakamura Hiroaki, Terai Hidetomi

Journal of Spine Research 2025.02 (一社)日本脊椎脊髄病学会
不安定性を伴う腰部脊柱管狭窄症に対する側方進入腰椎椎体間固定術後ASDの危険因子

澤田雄大, 高橋真治, 加藤相勲, 豊田宏光, 鈴木亨暢, 玉井孝司, 岩前真由, 岡村悠貴, 小林祐人, 中村博亮, 寺井秀富

Journal of Spine Research 2025.02 (一社)日本脊椎脊髄病学会
頸椎椎弓形成術の最前線　手術効率の改善と有効性の向上を目指して

玉井孝司

中部日本整形外科災害外科学会雑誌 2024.10 (一社)中部日本整形外科災害外科学会
脊椎転移治療の効果と限界　転移性脊椎腫瘍に対する椎体形成術の効果と限界

鈴木亨暢, 寺井秀富, 加藤相勲, 豊田宏光, 高橋真治, 玉井孝司

中部日本整形外科災害外科学会雑誌 2024.10 (一社)中部日本整形外科災害外科学会
骨粗鬆症性椎体骨折の保存加療における装具装着の効果　装具あり群と装具なし群の傾向スコアマッチング検定

岩前真由, 高橋真治, 寺井秀富, 玉井孝司, 星野雅俊, 馬野雅之, 小林祐人, 佐々木亮, 上松正人, 島田永和, 中村博亮

日本整形外科学会雑誌 2024.03 (公社)日本整形外科学会
骨粗鬆症性椎体骨折に対して保存療法を行った患者における治療満足度調査

小林祐人, 岩前真由, 玉井孝司, 高橋真治, 勝田紘史, 星野雅俊, 寺井秀富, 金田国一, 島田永和, 中村博亮

日本整形外科学会雑誌 2024.03 (公社)日本整形外科学会
腰部脊柱管狭窄症に対する内視鏡下椎弓切除術の臨床成績と成績不良因子

鈴木亨暢, 豊田宏光, 加藤相勲, 寺井秀富, 高橋真治, 玉井孝司, 中村博亮

日本整形外科学会雑誌 2024.03 (公社)日本整形外科学会
片開き式頸椎椎弓形成術の固定椎弓数削減法は全椎弓固定に劣らない　SKIP-2:多施設ランダム化比較試験術後1年時結果

玉井孝司, 寺井秀富, 鈴木亨暢, 寺川雅基, 高橋真治, 小林祐人, 馬野雅之, 星野雅俊, 辻尾唯雄, 安田宏之, 中村博亮

日本整形外科学会雑誌 2024.03 (公社)日本整形外科学会
低侵襲腰椎後方除圧術において抗血小板薬内服継続は周術期に影響を及ぼすか

澤田雄大, 玉井孝司, 豊田宏光, 寺井秀富, 加藤相勲, 鈴木亨暢, 高橋真治, 岩前真由, 岡村悠貴, 小林祐人, 中村博亮

日本整形外科学会雑誌 2024.03 (公社)日本整形外科学会
ポストコロナ時代の骨粗鬆症薬物治療はもっと若手が活躍するべきだ

玉井孝司

関東整形災害外科学会雑誌 2024.03 関東整形災害外科学会
高齢者における脊椎術後低栄養の発生率と危険因子

木下右貴, 玉井孝司, 岡誠, 鈴木亨暢, 寺井秀富, 加藤相勲, 高橋真治, 岩前真由, 小林祐人, 岡村悠貴, 澤田雄大, 中村博亮

Journal of Spine Research 2024.02 (一社)日本脊椎脊髄病学会
頸椎神経根症に対する超音波ガイド下神経根ブロックの有効性　ランダム化比較試験　中間報告

佐々木亮, 玉井孝司, 寺井秀富, 勝田紘史, 島田永和, 上松正人, 中村博亮

Journal of Spine Research 2024.02 (一社)日本脊椎脊髄病学会
頸椎症性脊髄症術後に遺残する上肢しびれは治療満足度に影響するか?

玉井孝司, 寺井秀富, 加藤相勲, 豊田宏光, 鈴木亨暢, 高橋真治, 澤田雄大, 岩前真由, 岡村悠貴, 小林祐人, 中村博亮

Journal of Spine Research 2024.02 (一社)日本脊椎脊髄病学会
頸椎症性脊髄症患者の「社会機能」に対する周術期多職種介入は術後成績を向上させる可能性がある

玉井孝司, 寺井秀富, 渡辺晋吾, 田代洋次, 大嶺俊充, 勝田紘史, 島田永和, 小林祐人, 中村博亮

Journal of Spine Research 2024.02 (一社)日本脊椎脊髄病学会
転移性脊椎腫瘍の予後予測スコア(NESMS)の検証

岡村悠貴, 鈴木亨暢, 寺井秀富, 加藤相勲, 豊田宏光, 高橋真治, 玉井孝司, 澤田雄大, 岩前真由, 小林祐人, 中村博亮

Journal of Spine Research 2024.02 (一社)日本脊椎脊髄病学会
腰椎術後鎮痛におけるジクロフェナク含有全身性経皮吸収型製剤の使用経験

上松正人, 百町貴彦, 百武紘史, 鈴木久崇, 舘弘之, 石川蓉子, 小甲晃史, 安倍雄一郎, 柳橋寧, 玉井孝司, 中村博

Journal of Spine Research 2024.02 (一社)日本脊椎脊髄病学会
腰椎変性疾患における椎間楔状化や側方すべりを有する椎間への後方手術の比較検討(低侵襲除圧術対除圧固定術)

加藤相勲, 寺井秀富, 並川崇, 松村昭, 星野雅俊, 豊田宏光, 鈴木享暢, 高橋真治, 玉井孝司, 澤田雄大, 岩前真由, 岡村悠貴, 小林祐人, 中村博亮

Journal of Spine Research 2024.02 (一社)日本脊椎脊髄病学会
腰椎側方椎体間固定術における自家骨移植の意義

小林祐人, 高橋真治, 寺井秀富, 加藤相勲, 星野雅俊, 豊田宏光, 鈴木亨暢, 玉井孝司, 澤田雄大, 岩前真由, 岡村悠貴, 中村博亮

Journal of Spine Research 2024.02 (一社)日本脊椎脊髄病学会
脊髄腫瘍手術における術後新規神経障害　発生頻度と発生後の改善

鈴木亨暢, 寺井秀富, 加藤相勳, 豊田宏光, 高橋真治, 玉井孝司, 岩前真由, 澤田雄大, 岡村悠貴, 小林祐人, 中村博亮

Journal of Spine Research 2024.02 (一社)日本脊椎脊髄病学会
片開き式頸椎椎弓形成の固定椎弓数削減法は全椎弓固定と比して非劣性である　SKIP-2　多施設ランダム化比較試験術後1年時結果

玉井孝司, 寺井秀富, 鈴木亨暢, 寺川雅基, 高橋真治, 小林祐人, 馬野雅之, 星野雅俊, 辻尾唯雄, 安田宏之, 岩前真由, 豊田宏光, 関昌彦, 加藤相勲, 中村博亮

Journal of Spine Research 2024.02 (一社)日本脊椎脊髄病学会
決定木分析を用いた腰椎低侵襲除圧術の術後臨床成績に影響を与える因子の探索

豊田宏光, 寺井秀富, 山田賢太郎, 加藤相勲, 鈴木亨暢, 高橋真治, 玉井孝司, 澤田雄大, 岩前真由, 小林祐人, 岡村悠貴, 中村博亮

Journal of Spine Research 2024.02 (一社)日本脊椎脊髄病学会
新鮮骨粗鬆症性椎体骨折の保存加療における装具装着の効果　装具あり群と装具なし群の傾向スコアマッチング検定

岩前真由, 高橋真治, 寺井秀富, 玉井孝司, 星野雅俊, 馬野雅之, 小林祐人, 佐々木亮, 上松正人, 加藤相勲, 豊田宏光, 鈴木亨暢, 勝田紘史, 島田永和, 中村博亮

Journal of Spine Research 2024.02 (一社)日本脊椎脊髄病学会
思春期特発性側彎症Lenke type 1-3に対する矯正固定術後の長期経過の報告　冠状面バランスに着目

岩前真由, 寺井秀富, 加藤相勲, 豊田宏光, 鈴木亨暢, 高橋真治, 玉井孝司, 澤田雄大, 岡村悠貴, 小林祐人, 中村博亮

Journal of Spine Research 2024.02 (一社)日本脊椎脊髄病学会
側方進入腰椎椎体固定術の間接除圧における隣接椎間障害の検討とその対策

澤田雄大, 高橋真治, 寺井秀富, 加藤相勲, 豊田宏光, 鈴木亨暢, 玉井孝司, 岩前真由, 岡村悠貴, 小林祐人, 中村博亮

Journal of Spine Research 2024.02 (一社)日本脊椎脊髄病学会
低用量アスピリン継続下での手術は腰椎内視鏡手術の周術期に影響を及ぼすか

上松正人, 玉井孝司, 澤田雄大, 寺井秀富, 金田国一, 勝田紘史, 島田永和, 中村博亮

Journal of Spine Research 2024.02 (一社)日本脊椎脊髄病学会
80歳以上および未満の骨粗鬆症性椎体骨折患者におけるexpandable cageの手術成績(Surgical results of Expandable cages in older and younger than 80 years old in Osteoporotic vertebral fracture)

Habibi Hasibullah, Terai Hidetomi, Tamai Koji, Salimi Hamidullah, Uematsu Masato, Katsuda Hiroshi, Shimada Nagakazu, Hiroaki Hiroaki

Journal of Spine Research 2024.02 (一社)日本脊椎脊髄病学会
AIS患者における矯正固定手術後2年の矢状面形状の変化と臨床成績との関係(Modification of sagittal profile and its relationship to clinical outcomes height 2 years after corrective surgery in AIS patient)

Salimi Hamidullah, Terai Hidetomi, Toyoda Hiromitsu, Takahashi Shinji, Tamai Koji, Nakamura Hirauki

Journal of Spine Research 2024.02 (一社)日本脊椎脊髄病学会
ASIA Impairment Scale C高齢頸髄症患者における治療介入後の神経症状推移と関連因子

玉井孝司, 寺井秀富, 加藤仁志, 中島宏彰, 安部哲哉, 名越慈人, 古矢丈雄, 中嶋秀明, 長谷川智彦, 寺島嘉紀, 中村博亮

Journal of Spine Research 2024.02 (一社)日本脊椎脊髄病学会
MBDU後の除圧椎間および非除圧椎間における術後の進行性椎間変性のリスク因子分析　5年間のFU研究(Risk factors analysis of postop progressive segment degeneration at decompression and non-decompression segments after MBDU: 5-year FU study)

Habibi Hasibullah, Toyoda Hiromitsu, Terai Hidetomi, Yamada Kentaro, Suzuki Akinobu, Takahashi Shinji, Tamai Koji, Katsuda Hiroshi, Shimada Nagakazu, Nakamura Hiroaki

Journal of Spine Research 2024.02 (一社)日本脊椎脊髄病学会
PEEK製ケージとチタン製ケージを用いたL5/S1 PLIFの癒合率、放射線学的パラメータの比較(Comparison of fusion rate, radiological parameters L5/S1 PLIF using PEEK versus titanium cages)

Salimi Hamidullah, Terai Hidetomi, Tamai Koji, Uematsu Masato, Katsuda Hiroshi, Shimada Nagakazu, Nakamura Hiroaki

Journal of Spine Research 2024.02 (一社)日本脊椎脊髄病学会

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Grant-in-Aid for Scientific Research

Exploratory analysis of Sex-Specific Mechanisms Underlying Osteoporosis Risk Induced by Exposure to Aerosols from Combustible and Heated Tobacco Products

Grant-in-Aid for Scientific Research(C) 2028
Role of Advanced Glycation End Products (AGEs) in ossification of posterior longitudinal ligament (OPLL)

Grant-in-Aid for Scientific Research(C) 2027
Exploratory analysis of Sex-Specific Mechanisms Underlying Osteoporosis Risk Induced by Exposure to Aerosols from Combustible and Heated Tobacco Products

Grant-in-Aid for Scientific Research(C) 2027
Role of Advanced Glycation End Products (AGEs) in ossification of posterior longitudinal ligament (OPLL)

Grant-in-Aid for Scientific Research(C) 2026
Exploratory analysis of Sex-Specific Mechanisms Underlying Osteoporosis Risk Induced by Exposure to Aerosols from Combustible and Heated Tobacco Products

Grant-in-Aid for Scientific Research(C) 2026
Role of Advanced Glycation End Products (AGEs) in ossification of posterior longitudinal ligament (OPLL)

Grant-in-Aid for Scientific Research(C) 2025
Basic science study of the impact of heated tobacco cessation on the bone healing

Grant-in-Aid for Scientific Research(C) 2025
慢性頚髄圧迫モデルラットの脊髄症状進行に対する電子タバコエアロゾルの影響

Grant-in-Aid for Early-Career Scientists 2020.04
電子タバコのエアロゾル吸入が骨癒合に及ぼす影響の検証と禁煙の有効性評価

2019.04

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Joint research

頚椎側面レントゲン画像の骨構造解析による骨粗鬆症リスク評価AIシステムおよび多施設汎用化技術の研究開発

成長型中小企業等研究開発支援事業（Go-Tech事業） 2026.06

Outline of education staff

整形外科一般、脊椎外科一般

Charge of on-campus class subject

整形外科学1

2026 Weekly class Undergraduate
運動器

2025 Weekly class Undergraduate
整形外科学1

2025 Weekly class Undergraduate

Social Activities　⇒ Link to the list of Social Activities

動いて守る健康寿命！寝たきりを予防するための大阪公立大学と大阪府市の取り組み

Role(s)： Lecturer

Type： Lecture

大阪公立大学医学部附属病院第294回市民医学講座 2026.07

　More details

SDGs：

Number of participants：120（人）

大阪公立大学は大阪府・大阪市と協力し、年を重ねても自分の足で動ける健康づくりに取り組んでいます。本講座では、寝たきりを防ぎ、元気に暮らせる時間を延ばす秘訣を、これまでの調査結果を交えながら紹介した。

Media Coverage

高齢者の転倒・骨折、多剤併用と体重減少に注意　大阪公立大が大規模調査　恐れず体動かして

毎日新聞 2026.07

　 More details

SDGs：
高齢者の転倒・骨折、多剤併用と体重減少に注意　大阪公立大が大規模調査　恐れず体動かして

産経新聞 2026.06

　 More details

SDGs：

International exchange activities

カンボジア・プノンペンにおいて、頚椎領域を中心とした手術支援ならびに教育研修セミナー、手術手技ワークショップを実施した。

Field category :Education

2026.02
North America Spine SocietyのInternational Strategic Growth Committee委員として、タイや台湾、サウジアラビアなどで教育講演を行っている。

2024.09 - Now
SPINE20 Scientific Committee委員長として、G20諸国に対して政策提言作成、シンポジウム企画・運営を主導。

Field category :Social contributions

2019 - Now

Position

Position

Degree

Degree

Research Areas

Research Areas

Research Interests

Research Interests

Professional Memberships

Professional Memberships

Committee Memberships (off-campus)

Committee Memberships (off-campus)

Awards

Awards

Job Career (off-campus)

Job Career (off-campus)

Papers

Papers

MISC

MISC

Presentations

Presentations

Grant-in-Aid for Scientific Research

Grant-in-Aid for Scientific Research

Joint research

Joint research

Outline of education staff

Outline of education staff

Charge of on-campus class subject

Charge of on-campus class subject

Social Activities ⇒ Link to the list of Social Activities

Social Activities ⇒ Link to the list of Social Activities

Media Coverage

Media Coverage

International exchange activities

International exchange activities

Social Activities　⇒ Link to the list of Social Activities

Social Activities　⇒ Link to the list of Social Activities