Updated on 2026/02/25

写真a

 
UEDONO HIDEKI
 
Organization
Graduate School of Medicine Department of Clinical Medical Science Lecturer
School of Medicine Department of Medical Science
Title
Lecturer
Affiliation
Institute of Medcine
Affiliation campus
Abeno Campus

Position

  • Graduate School of Medicine Department of Clinical Medical Science 

    Lecturer  2025.04 - Now

  • School of Medicine Department of Medical Science 

    Lecturer  2025.04 - Now

Degree

  • 博士（医学） （ Osaka City University ）

Research Areas

  • Life Science / Nephrology  / Fetuin-A, Calciprotein particle, Protein energy wasting, SGLT2阻害薬

Research Interests

  • Fetuin-A, Calciprotein particle, Protein energy wasting, SGLT2阻害薬,

Research Career

  • 血液透析患者におけるPEW・栄養障害、MDSC、感染症の関連

    myeloid-derived suppressor cells ,protein-energy wasting  

    2022.04 - Now 

  • 2型糖尿病におけるカナグリフロジンの腎RI、腎酸素化改善との関連

    カナグリフロジン、resistive index、Bold MRI 

    2024.09 - Now 

  • Effects of calciprotein particles on hepcidin expression in hepatocytes

    Individual

    2021.04 - Now 

Professional Memberships

  • 日本腎臓学会

    2013.07 - Now   Domestic

  • 日本透析学会

    2013.05 - Now   Domestic

  • 日本内科学会

    2013.08 - Now   Domestic

  • 日本糖尿病学会

    2013.07 - Now   Domestic

  • 日本病態栄養学会

    2025.01 - Now   Domestic

  • 一般社団法人多発性嚢胞腎協会

    2025.02 - Now   Domestic

▼display all

Awards

  • YIA (若手研究独創賞)

    上殿　英記 、森　克仁 、小野　克宏、岡崎　久宜、 仲谷　慎也 、兵頭　正浩、吉田　寿子、庄司　繁市、 山川　智之、繪本　正憲

    2026.02   日本病態栄養学会年次学術集会   血液透析患者におけるPMN-MDSCとGNRIの関連

  • 大阪市立大学医学部長賞奨励賞

    上殿　英記

    2018.04   大阪市立大学大学院医学研究科  

Papers

  • Definition of hyperfiltration taking into account age-related decline in renal function in kidney donor candidates with obesity and glucose tolerance disorder

    Tsuda A.

    Hypertension Research   48 ( 3 )   1115 - 1124   2025.03（ ISSN:09169636 ）

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  • An autopsy-proven case of normotensive scleroderma renal crisis with refractory pleuroperitoneal effusion.

    2025

  • Associations of Cognitive Function with Serum Magnesium and Phosphate in Hemodialysis Patients: A Cross-Sectional Analysis of the Osaka Dialysis Complication Study (ODCS)

    Shoji T.

    Nutrients   16 ( 21 )   2024.11

    　More details

  • Association Between Plasma Aldosterone Concentration and Intraglomerular Hemodynamics in Primary Aldosteronism

    Uedono H.

    American Journal of Hypertension   37 ( 10 )   801 - 809   2024.10（ ISSN:08957061 ）

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  • Association between Serum Zinc and All-Cause Mortality in Patients Undergoing Maintenance Hemodialysis: The Osaka Dialysis Complication Study (ODCS)

    Nakatani S.

    Nutrients   16 ( 19 )   2024.10

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  • New-onset Kidney Biopsy-proven Membranous Nephropathy Induced End-stage Kidney Disease in a Living Donor

    Morioka Fumiyuki, Nakatani Shinya, Mori Katsuhito, Naganuma Toshihide, Yamasaki Takeshi, Uedono Hideki, Tsuda Akihiro, Ishimura Eiji, Uchida Junji, Emoto Masanori

    Internal Medicine   63 ( 18 )   2537 - 2541   2024.09（ ISSN:09182918 ） （ eISSN:13497235 ）

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    <p>Thirteen years after kidney donation, a 70-year-old man was referred to a nephrologist because of proteinuria. The serum creatinine, albumin, and urinary protein levels were 2.39 mg/dL, 3.0 g/dL, and 6.72 g/gCr, respectively. A kidney biopsy revealed thickening of the glomerular basement membrane with sub-epithelial deposits, suggesting membranous nephropathy. Considering the apparent interstitial fibrosis and diffuse glomerulosclerosis, supportive treatment was chosen. However, 11 months after the kidney biopsy, hemodialysis was required. The present case constitutes an important teaching point, as glomerular disease can occur in living donors and require careful and long-term medical checkup examinations. </p>

    DOI： 10.2169/internalmedicine.2814-23

    PubMed

    CiNii Research

  • 生体ドナーにおける腎生検で確認された膜性腎症による末期腎疾患の新規発症(New-onset Kidney Biopsy-proven Membranous Nephropathy Induced End-stage Kidney Disease in a Living Donor)

    Morioka Fumiyuki, Nakatani Shinya, Mori Katsuhito, Naganuma Toshihide, Yamasaki Takeshi, Uedono Hideki, Tsuda Akihiro, Ishimura Eiji, Uchida Junji, Emoto Masanori

    Internal Medicine   63 ( 18 )   2537 - 2541   2024.09（ ISSN:0918-2918 ）

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    症例は70歳男性で、タンパク尿のために来院した。患者は56歳時に腎移植ドナーとなっており、腎提供後6年は腎機能が維持されていたが、尿中タンパク陽性となり、アジルサルタン治療を開始していた。腎提供後13年時に紹介来院した際の血清クレアチニンは2.39mg/dL、推算糸球体濾過量は22.1mL/分/1.73m2、血清アルブミンは3.0g/dL、尿中タンパクは6.72g/gCrであった。入院3日目に開腹腎生検を行い、上皮下沈着物を伴う糸球体基底膜の肥厚が明らかとなり、ステージIV膜性腎症(MN)と診断した。胸腹部CTで悪性腫瘍は示されず、上下部消化管内視鏡検査でも明らかな消化管腫瘍は認められなかった。MNの二次性原因のスクリーニングは陰性であったことから、原発性MNと診断した。著明な間質線維化とび漫性糸球体硬化症を考慮し、慢性腎臓病に対する支持療法を行ったが、腎生検の11ヵ月後に血液透析を要する末期腎疾患となった。

  • Dapagliflozin administration for 1 year promoted kidney enlargement in patient with ADPKD

    Nakatani S.

    CEN Case Reports   13 ( 4 )   284 - 289   2024.08

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  • Dapagliflozin administration for 1 year promoted kidney enlargement in patient with ADPKD(タイトル和訳中)

    Nakatani Shinya, Morioka Fumiyuki, Uedono Hideki, Tsuda Akihiro, Mori Katsuhito, Emoto Masanori

    CEN Case Reports   13 ( 4 )   284 - 289   2024.08

  • Differential associations of fetuin-A and calcification propensity with cardiovascular events and subsequent mortality in patients undergoing hemodialysis

    Mori K.

    Clinical Kidney Journal   17 ( 3 )   sfae042   2024.03（ ISSN:20488505 ）

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  • Novel Digenic Variants in COL4A4 and COL4A5 Causing X-Linked Alport Syndrome: A Case Report

    Uedono H.

    Case Reports in Nephrology and Dialysis   14 ( 1 )   1 - 9   2024.01（ ISSN:2296-9705 ）

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  • 特集 透析診療のすべて Part 2　透析管理の基本と原則 5.血液透析患者におけるドライウェイト(DW)のマネジメント-数値の背景にあるDWの考え方を知る

    上殿 英記, 森岡 史行

    Hospitalist   11 ( 2 )   309 - 318   2024.01（ ISSN:21880409 ） （ eISSN:21896429 ）

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  • Associations of Cognitive Function with Serum Magnesium and Phosphate in Hemodialysis Patients: A Cross-Sectional Analysis of the Osaka Dialysis Complication Study (ODCS).

    Shoji T, Mori K, Nagakura Y, Kabata D, Kuriu K, Nakatani S, Uedono H, Nagata Y, Fujii H, Imanishi Y, Morioka T, Emoto M.

    2024

  • T50 Calciprotein Crystallization and the Decreased Role of Fetuin-A in Type 2 Diabetes

    Nagakura Yu, Shoji Tetsuo, Fukumoto Shinya, Uedono Hideki, Nakatani Shinya, Mori Katsuhito, Nagata Yuki, Imanishi Yasuo, Morioka Tomoaki, Watanabe Toshio, Emoto Masanori

    Journal of Atherosclerosis and Thrombosis   advpub ( 0 )   2024（ ISSN:13403478 ） （ eISSN:18803873 ）

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    <p> <b>Aim:</b> Patients with type 2 diabetes mellitus (T2D) are prone to develop vascular calcification. Fetuin-A protects against vascular calcification but it increases insulin resistance. T50 calciprotein crystallization (also called serum calcification propensity) is a novel marker of calcification stress. This study examined whether T2D affects T50 and the potential role of fetuin-A in the relationship between T2D and T50.</p><p><b>Methods:</b> This cross-sectional study included 101 individuals with T2D and 101 individuals without diabetes (controls). T50 and fetuin-A levels were measured using the established nephelometric method and an enzyme-linked immunosorbent assay, respectively.</p><p><b>Results:</b> Although fetuin-A levels were higher in the T2D group, T50 was not significantly different between the T2D and control groups. In multivariable-adjusted analyses of the total population, T50 was not independently associated with the presence of T2D, fasting plasma glucose, or HbA1c, whereas T50 was significantly associated with fetuin-A, phosphate, and calcium levels. The association between T50 and fetuin-A was modified by the presence of T2D. A subgroup analysis revealed that the positive association between T50 and fetuin-A was significant but smaller in the T2D group, and that the associations of T50 with serum phosphate and calcium were more evident in the T2D group. Additional analyses showed that T50/fetuin-A ratio was lower in the T2D group and that T50/fetuin-A ratio was inversely correlated with fasting glucose and HbA1c levels.</p><p><b>Conclusions:</b> T2D itself was not significantly associated with T50 but T2D modified the association between T50 and fetuin-A in favor of developing vascular calcification in T2D.</p>

    DOI： 10.5551/jat.65351

    PubMed

    CiNii Research

  • Effects of canagliflozin on kidney oxygenation evaluated using blood oxygenation level-dependent MRI in patients with type 2 diabetes

    Mori K.

    Frontiers in Endocrinology   15   1451671   2024（ ISSN:1664-2392 ）

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  • Novel Digenic Variants in COL4A4 and COL4A5 Causing X-Linked Alport Syndrome: A Case Report

    2024

  • Association Between Plasma Aldosterone Concentration and Intraglomerular Hemodynamics in Primary Aldosteronism

    Uedono H, Kurajoh M, Toi N, Tsuda A, Shinmaru K, Miki Y, Nakatani S, Nagata Y, Morioka T, Mori K, Imanishi Y, Emoto M.

    Am J Hypertens.   2024

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    Authorship：Lead author,　Corresponding author  

  • 慢性腎臓病における血管石灰化の病態と治療

    森　克仁、仲谷　慎也、上殿　英記、庄司　哲雄

    腎臓内科   17 ( 1 )   15 - 20   2023

  • Serum phosphate as an independent factor associated with cholesterol metabolism in patients undergoing hemodialysis: a cross-sectional analysis of the DREAM cohort

    Okute Y, Shoji T, Shimomura N, Tsujimoto Y, Nagata Y, Uedono H, Nakatani S, Morioka T, Mori K, Fukumoto S, Imanishi Y, Emoto M.

    Nephrol Dial Transplant.   31 ( 38 )   2023

  • 17. Short-Term Dapagliflozin Administration in Autosomal Dominant Polycystic Kidney Disease-A Retrospective Single-Arm Case Series Study

    Morioka F, Nakatani S, Uedono H, Tsuda A, Mori K, Emoto M.

    J Clin Med.   12 ( 19 )   6341   2023

  • 血液浄化法に応じた食と栄養 　　通常血液透析

    上殿　英記、森　克仁

    臨床透析   39 ( 12 )   1377 - 1383   2023

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    Authorship：Lead author  

  • 栄養評価と早期介入がポイント　ナースが防ぐ！透析患者の低栄養&食欲低下 クレアチニン・クレアチン産生速度

    上殿　英記、森　克仁

    透析ケア   29 ( 10 )   915 - 917   2023

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    Authorship：Lead author  

  • 糖尿病透析患者の全身管理を極める-専門医との連携を目指して-低血糖予防　どう防いだらいいか

    上殿　英記、森　克仁

    臨床透析   39 ( 1 )   37 - 42   2023

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    Authorship：Lead author  

  • T50(血清石灰化傾向) 石灰化ストレスの指標

    庄司 哲雄、仲谷　慎也、上殿　英記、永倉　優、永田　友貴、森岡　与明、森克仁、繪本　正憲

    腎臓内科   17 ( 1 )   104 - 111   2023

  • Seronegative Full-house Nephropathy with Crohn's Disease.

    2022

  • 15. Nutritional Disorder Evaluated by the Geriatric Nutritional Risk Index Predicts Death After Hospitalization for Infection in Patients Undergoing Maintenance Hemodialysis

    Machiba Y, Mori K, Shoji T, Nagata Y, Uedono H, Nakatani S, Ochi A, Tsuda A, Morioka T, Yoshida H, Tsujimoto Y, Emoto M.

    J Ren Nutr.   32 ( 6 )   751 - 757   2022

  • 【腎疾患治療薬update】腎疾患患者への薬の使い方 糖尿病腎臓病 GLP-1受容体作動薬

    上殿　英記、森　克仁

    腎と透析   91   102 - 106   2022

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    Authorship：Lead author  

  • Clinical and histopathological features of acute kidney injury in adult-onset minimal change nephrotic syndrome

    Nishide K, Nakatani S, Mori K, Morioka F, Machiba Y, Uedono H, Tsuda A, Inaba M, Ishimura E, Emoto M.

    Clin Exp Nephrol   2021

  • Cinacalcet may suppress kidney enlargement in hemodialysis patients with autosomal dominant polycystic kidney disease

    Nishide K, Nakatani S, Mori K, Morioka F, Machiba Y, Uedono H, Tsuda A, Inaba M, Ishimura E, Emoto M.

    Clin Exp Nephrol.   25 ( 3 )   261 - 269   2021

  • Effects of fetuin-A-containing calciprotein particles on posttranslational modifications of fetuin-A in HepG2 cells. Reviewed

    Uedono H, Mori K, Ochi A, Nakatani S, Miki Y, Tsuda A, Morioka T, Nagata Y, Imanishi Y, Shoji T, Inaba M, Emoto M.

    Scientific Reports   11   2021

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    Authorship：Lead author  

  • Dissociation of Glycated Albumin and HbA1c Is Associated With a Decline of Glomerular Filtration Rate as Evaluated by Inulin Clearance

    Tsuda A, Mori K, Nakatani S, Machiba Y, Uedono H, Kurajoh M, Yamada S, Morioka T, Inaba M, Ishimura E, Uchida J, Emoto M.

    Diabetes Care.   44 ( 11 )   e188 - e189   2021

  • Plasma Xanthine Oxidoreductase Activity Associated with Glycemic Control in Patients with Pre-Dialysis Chronic Kidney Disease

    Nakatani S, Ishimura E, Murase T, Nakamura T, Nakatani A, Toi N, Nishide K, Uedono H, Tsuda A, Kurajoh M, Yamada S, Mori K, Inaba M, Emoto M.

    Kidney Blood Press Res.   46 ( 4 )   475 - 483   2021

  • 多発性嚢胞腎に対するHIF-PH阻害薬の影響

    仲谷　慎也、上殿　英記、西出　孝蔵

    腎臓内科   14 ( 5 )   595 - 601   2021

  • 【加齢と腎泌尿器医療】高齢腎疾患患者の脂質管理

    上殿　英記、森　克仁

    腎と透析   90 ( 6 )   2021

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    Authorship：Lead author  

  • Association between Serum Zinc and Calcification Propensity (T50) in Patients with Type 2 Diabetes Mellitus and In Vitro Effect of Exogenous Zinc on T50.

    Nakatani S, Mori K, Sonoda M, Nishide K, Uedono H, Tsuda A, Emoto M, Shoji T.

    Biomedicines   8 ( 9 )   337   2020

  • Increased Glomerular Hydrostatic Pressure is Associated with Tubular Creatinine Reabsorption in Healthy Subjects

    Tsuda A, Ishimura E, Machiba Y, Uedono H, Nakatani S, Mori K, Uchida J, Emoto M.

    Kidney Blood Press Res.   45 ( 6 )   996 - 1008   2020

  • (CKD－MBD）Ca受容体作動薬と活性型VD製剤の選択と併用

    仲谷　慎也、上殿　英記、森　克仁、庄司哲雄

    腎臓内科   11 ( 5 )   2020

  • 【血糖コントロールの改善・安定化のコツとポイントにつながる(19)症例　とことんわかる血糖値】腎障害のある患者

    上殿　英記、森　克仁

    糖尿病ケア   174 - 178   2020

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    Authorship：Lead author  

  • Oncostatin M induces C2C12 myotube atrophy by modulating muscle differentiation and degradation.

    Miki Y, Morioka T, Shioi A, Fujimoto K, Sakura T, Uedono H, Kakutani Y, Ochi A, Mori K, Shoji T, Emoto M, Inaba M.

    Biochem Biophys Res Commun   27   951 - 956   2019

  • Non-mercaptalbumin, Oxidized Form of Serum Albumin, Significantly Associated with Renal Function and Anemia in Chronic Kidney Disease Patients

    Nakatani S, Yasukawa K, Ishimura E, Nakatani A, Toi N, Uedono H, Tsuda A, Yamada S, Ikeda H, Mori K, Emoto M, Yatomi Y, Inaba M.

    Sci Rep.   14 ( 8 )   16796   2018

  • Association of Albuminuria With Intraglomerular Hydrostatic Pressure and Insulin Resistance in Subjects With Impaired Fasting Glucose and/or Impaired Glucose Tolerance

    Tsuda A, Ishimura E, Uedono H, Ochi A, Nakatani S, Morioka T, Mori K, Uchida J, Emoto M, Nakatani T, Inaba M.

    Diabetes Care.   41 ( 11 )   2414 - 2420   2018

  • U-shaped relationship between serum uric acid levels and intrarenal hemodynamic parameters in healthy subjects.

    Uedono H, Tsuda A, Ishimura E, Nakatani S, Kurajoh M, Mori K, Uchida J, Emoto M, Nakatani T, Inaba M.

    Am J Physiol Renal Physiol.   2017.06

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    Authorship：Lead author  

  • Comparison of the Estimated Glomerular Filtration Rate (eGFR) in Diabetic Patients, Non-Diabetic Patients and Living Kidney Donors

    Tsuda A, Ishimura E, Uedono H, Yasumoto M, Ichii M, Nakatani S, Mori K, Uchida J, Emoto M, Nakatani T, Inaba M.

    Kidney Blood Press Res.   41 ( 1 )   40 - 47   2016

  • Relationship between serum uric acid levels and intrarenal hemodynamic parameters

    Uedono H, Tsuda A, Ishimura E, Yasumoto M, Ichii M, Ochi A, Ohno Y, Nakatani S, Mori K, Uchida J, Nakatani T, Inaba M.

    2015.06

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    Authorship：Lead author  

  • Significant association between glycemic status and increased estimated postglomerular resistance in nondiabetic subjects - study of inulin and para-aminohippuric acid clearance in humans

    3   e12321   2015

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MISC

  • 【透析診療のすべて】(Part 2)透析管理の基本と原則　血液透析患者におけるドライウェイト(DW)のマネジメント　数値の背景にあるDWの考え方を知る

    上殿 英記, 森岡 史行

    Hospitalist   11 ( 2 )   309 - 318   2024.01（ ISSN:2188-0409 ）

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    ＜文献概要＞血液透析患者において安全に透析治療を行うことは,生命予後,QOLの面から非常に重要である。透析中の過度な血圧変動をなくし,体内水分量を至適な状態にすることを目標とするが,体重管理にゴールドスタンダードは存在せず,透析医療に携わる医療者にとって頭を悩ませる問題となっている。本稿では,筆者が実臨床で体重管理に難渋した以下のような症例をふまえ,血液透析患者におけるドライウェイト(DW)の定義や設定方法について,エビデンスを交えて考察する。またDW維持のための方法とともに,速すぎる限外濾過速度の弊害についても概説する。

Presentations

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Grant-in-Aid for Scientific Research

  • Calciprotein particles (CPP)のヘプシジンを介した腎性貧血への影響

    Grant-in-Aid for Early-Career Scientists  2027

  • Calciprotein particles (CPP)のヘプシジンを介した腎性貧血への影響

    Grant-in-Aid for Early-Career Scientists  2026

  • Calciprotein particles (CPP)のヘプシジンを介した腎性貧血への影響

    Grant-in-Aid for Early-Career Scientists  2025

Outline of education staff

  • 病棟および外来実習の医学生に対し、患者診察、問診を中心に指導を行っております。また、腎病理の解読方法についてスライドを使用して講義を行い、実際の医師国家試験の過去問などの演習を学生主体で進め、その指導を行っている。

Charge of on-campus class subject

  • 腎臓病態内科学（基礎研究-演習）

    2025   Intensive lecture   Graduate school

  • 腎臓病態内科学（臨床研究-演習）

    2025   Intensive lecture   Graduate school

  • 腎臓病態内科学（病理・診断・治療セミナー）

    2025   Intensive lecture   Graduate school

  • 腎臓病態内科学（腎臓学-総論）

    2025   Intensive lecture   Graduate school

Number of instructed thesis, researches

  • 2025

    Number of instructed the graduation thesis：1 

    [Number of instructed the Master's Program] (previous term)：1