Updated on 2026/07/27

写真a

 
UEDONO HIDEKI
 
Organization
Graduate School of Medicine Department of Clinical Medical Science Lecturer
School of Medicine Department of Medical Science
Title
Lecturer
Affiliation
Institute of Medcine
Affiliation campus
Abeno Campus

Position

  • Graduate School of Medicine Department of Clinical Medical Science 

    Lecturer  2025.04 - Now

  • School of Medicine Department of Medical Science 

    Lecturer  2025.04 - Now

Degree

  • 博士（医学） （ Osaka City University ）

Research Areas

  • Life Science / Nephrology  / 慢性腎臓病, Calciprotein particle, Fetuin-A,病態栄養学, 腎血行動態,糖尿病性腎症

Research Interests

  • 病態栄養学

  • 慢性腎臓病

  • Fetuin-A

  • Calciprotein particles

  • 糖尿病性腎症

  • 腎血行動態

Research Career

  • 血液透析患者におけるPEW・栄養障害、MDSC、感染症の関連

    myeloid-derived suppressor cells ,protein-energy wasting  

    2022.04 - Now 

  • 2型糖尿病におけるカナグリフロジンの腎RI、腎酸素化改善との関連

    カナグリフロジン、resistive index、Bold MRI 

    2024.09 - Now 

  • Effects of calciprotein particles on hepcidin expression in hepatocytes

    Individual

    2021.04 - Now 

Professional Memberships

  • 日本腎臓学会

    2013.07 - Now   Domestic

  • 日本透析学会

    2013.05 - Now   Domestic

  • 日本内科学会

    2013.08 - Now   Domestic

  • 日本糖尿病学会

    2013.07 - Now   Domestic

  • 日本病態栄養学会

    2025.01 - Now   Domestic

  • 一般社団法人多発性嚢胞腎協会

    2025.02 - Now   Domestic

  • 日本病態栄養学会

    2025.01

  • 多発性嚢胞腎協会

    2024.11

  • 日本糖尿病学会

    2013.11 - Now

  • 日本内科学会

    2013.08 - Now

  • 日本腎臓学会

    2013.07

  • 日本透析医学会

    2013.05

▼display all

Committee Memberships (off-campus)

  • 日本腎臓学会   評議員  

    2023.04 - Now 

Awards

  • 第29回日本病態栄養学会年次学術集会YIA(若手研究独創賞）

    上殿　英記 、森　克仁 、小野　克宏、岡崎　久宜、 仲谷　慎也 、兵頭　正浩、吉田　寿子、庄司　繁市、 山川　智之、繪本　正憲

    2026.01   日本病態栄養学会年次学術集会   血液透析患者におけるPMN-MDSCとGNRIの関連

  • 大阪市立大学医学部長賞奨励賞

    上殿　英記

    2018.04   大阪市立大学大学院医学研究科  

Job Career (off-campus)

  • 大阪公立大学大学院医学研究科   代謝内分泌病態内科学   講師

    2025.04 - Now

  • 大阪公立大学大学院医学研究科   代謝内分泌病態内科学   病院講師

    2022.04 - 2025.03

Papers

  • Cross-sectional Associations of Serum Sodium, Potassium, and Chloride with Cognition in Patients on Hemodialysis: The Osaka Dialysis Complication Study (ODCS).

    Tetsuo Shoji, Shinya Nakatani, Katsuhito Mori, Daijiro Kabata, Hisako Fujii, Rino Nakaya, Hideki Uedono, Yuki Nagata, Yasuo Imanishi, Tomoaki Morioka, Masanori Emoto

    Kidney medicine   8 ( 6 )   101369 - 101369   2026.06

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    Publishing type：Research paper (scientific journal)   International / domestic magazine：International journal  

    RATIONALE & OBJECTIVES: Cognitive function is impaired in patients with chronic kidney disease, particularly in those undergoing hemodialysis, although the precise mechanisms are not well understood. This cross-sectional study examined the possible relationship between serum electrolyte levels and cognitive function in patients receiving maintenance hemodialysis. STUDY DESIGN: Cross-sectional study. SETTINGS & PARTICIPANTS: Eligible patients were selected from the participants of the Osaka Dialysis Complication Study, a multicenter study conducted in Japan. EXPOSURES: Serum sodium, potassium, and chloride levels. OUTCOMES: Cognitive function assessed by the Modified Mini-Mental State examination (3MS) which was mathematically transformed to 3MS' to follow a normal distribution. ANALYTICAL APPROACH: Multivariable-adjusted linear regression analysis. RESULTS: For this study, 1,207 patients were selected. Their median age, 3MS score, serum sodium, potassium, and chloride concentrations were 67 (IQR, 60-74) years, 91 (IQR, 82-97) points, 139 (IQR, 137-141) mEq/L, 4.7 (IQR, 4.2-5.2) mEq/L, and 102 (IQR, 99-105) mEq/L, respectively. After adjustment, sodium (P = 0.23) or potassium (P = 0.38) were not associated with the 3MS score, whereas serum chloride was positively associated with the 3MS score (3MS', regression coefficient 0.100 [0.062, 0.138] per 1 IQR (6 mEq/L), P < 0.001) independently of potential confounders. The positive association between serum chloride and cognition was consistent in subgroup analysis. The difference in the 3MS score by 1 IQR of chloride was comparable to that of the difference by 7 years of age. LIMITATIONS: Causality cannot be determined because of the cross-sectional design. CONCLUSIONS: This study revealed that serum chloride level was a novel factor independently associated with cognitive performance in patients on maintenance hemodialysis, suggesting an unrecognized role of chloride in cognition.

    DOI： 10.1016/j.xkme.2026.101369

    PubMed

  • Association between serum zinc and cognitive function in patients undergoing maintenance hemodialysis; the Osaka Dialysis Complication Study (ODCS)

    Shinya Nakatani, Fumiyuki Morioka, Tetsuo Shoji, Kazuma Sone, Hideki Uedono, Akihiro Tsuda, Hisako Fujii,Yasuo Imanishi, Masanori Emoto

    30 ( 6 )   936 - 945   2026.06

  • Inverse Association between T50 Calciprotein Crystallization (Serum Calcification Propensity) and Carotid Artery Intima-Media Thickness in Health Examinees with a Reduced Kidney Function

    Nagakura Yu, Shoji Tetsuo, Fukumoto Shinya, Uedono Hideki, Nakatani Shinya, Mori Katsuhito, Nagata Yuki, Imanishi Yasuo, Morioka Tomoaki, Watanabe Toshio, Emoto Masanori

    Journal of Atherosclerosis and Thrombosis   33 ( 5 )   632 - 642   2026.05（ ISSN:13403478 ） （ eISSN:18803873 ）

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    Publishing type：Research paper (scientific journal)   International / domestic magazine：Domestic journal  

    <p><b>Aim:</b> T50 is the time required for primary calciprotein particles (CPPs) to transform into secondary CPPs <i>in vitro</i>, reflecting serum calcification propensity, and used as a biomarker for calcification stress. Since secondary CPPs induce inflammation and oxidative stress, they may promote atherosclerosis. We investigated whether or not T50 was associated with carotid artery intima-media thickness (IMT).</p><p><b>Methods:</b> This was a cross-sectional study of 202 health examinees. T50 was measured by the established nephelometric method. Carotid artery IMT was measured by high-resolution ultrasonography. The association between T50 and IMT was evaluated by a multivariable-adjusted linear regression analysis.</p><p><b>Results:</b> In a univariate analysis, IMT was not significantly correlated with T50. A multivariable-adjusted linear regression analysis showed that IMT was independently associated with age, sex, diabetes mellitus, dyslipidemia, and fetuin-A but not with T50 in the total subjects. However, when stratified by the estimated glomerular filtration rate (eGFR), T50 was independently and inversely associated with IMT in the subgroup with an eGFR ＜60 mL/min/1.73 m<sup>2</sup> (β = −0.418, P = 0.013), whereas it was not in the subgroup with an eGFR ≥ 60 mL/min/1.73 m<sup>2</sup>.</p><p><b>Conclusion:</b> T50 was independently and inversely associated with IMT in health examinees with a reduced kidney function, suggesting a novel link between calcification stress and atherosclerosis, particularly in those with chronic kidney disease.</p>

    DOI： 10.5551/jat.65964

    PubMed

    CiNii Research

  • Inverse Association between T50 Calciprotein Crystalization(Serum Calcification Propensity) and Carotid Artery Intima-Media Thickness in Health Examinees with a Reduced Kidney Function(タイトル和訳中)

    Nagakura Yu, Shoji Tetsuo, Fukumoto Shinya, Uedono Hideki, Nakatani Shinya, Mori Katsuhito, Nagata Yuki, Imanishi Yasuo, Morioka Tomoaki, Watanabe Toshio, Emoto Masanori

    Journal of Atherosclerosis and Thrombosis   33 ( 5 )   632 - 642   2026.05（ ISSN:1340-3478 ）

  • An autopsy-proven case of normotensive scleroderma renal crisis with refractory pleuroperitoneal effusion(タイトル和訳中)

    Uedono Hideki, Mori Katsuhito, Nakatani Shinya, Watanabe Kohei, Furuya Masahiko, Morioka Fumiyuki, Sone Kazuma, Miki Yuya, Tsuda Akihiro, Tanaka Sayaka, Morioka Tomoaki, Kohashi Kenichi, Emoto Masanori

    CEN Case Reports   15 ( 2 )   s13730 - 025   2026.04

  • An autopsy-proven case of normotensive scleroderma renal crisis with refractory pleuroperitoneal effusion.

    Hideki Uedono, Katsuhito Mori, Shinya Nakatani, Kohei Watanabe, Masahiko Furuya, Fumiyuki Morioka, Kazuma Sone, Yuya Miki, Akihiro Tsuda, Sayaka Tanaka, Tomoaki Morioka, Kenichi Kohashi, Masanori Emoto

    CEN case reports   15 ( 2 )   52 - 52   2026.02

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    Publishing type：Research paper (scientific journal)   International / domestic magazine：Domestic journal  

    INTRODUCTION: Scleroderma renal crisis (SRC) is a serious complication of systemic sclerosis that typically presents with hypertension and acute kidney injury (AKI). However, about 10% of cases are normotensive, while refractory pleural or ascitic effusion preceding SRC is rare in clinical practice. Here, we present a case of normotensive SRC preceded by refractory pleural and ascitic effusions. CASE PRESENTATION: The patient was a 66-year-old woman with a history of rheumatoid arthritis who was managed as an outpatient. Three months prior to admission, she developed sudden, generalized refractory pleural and ascitic effusions; however, the cause remained unknown and there was no improvement. Subsequently, she developed AKI and was transferred to our hospital. Hemodialysis was initiated, but despite efforts to reduce dry weight, transudative pleural effusion persisted. The patient was positive for anti-SCL-70 antibodies, but had no hypertension, and a kidney biopsy could not be performed. She later developed pneumonia and ultimately died of respiratory failure caused by pneumonia and pleural effusion. An autopsy revealed widespread fibrosis in multiple organs and marked intimal thickening and stenosis of the vasculature, leading to a diagnosis of normotensive SRC. CONCLUSION: It is important to consider normotensive SRC as a potential cause of refractory transudative pleural and ascitic effusions resistant to treatment with hemodialysis associated with AKI.

    DOI： 10.1007/s13730-025-01043-9

    PubMed

  • Correction: Estimated T50 calciprotein crystallization test in patients undergoing hemodialysis: Osaka Dialysis Complication Study (ODCS).

    Tetsuo Shoji, Daijiro Kabata, Yu Nagakura, Shinya Nakatani, Hideki Uedono, Yuki Nagata, Hisako Fujii, Katsuhito Mori, Yasuo Imanishi, Tomoaki Morioka, Masanori Emoto

    Clinical and experimental nephrology   30 ( 1 )   180 - 182   2026.01（ ISSN:13421751 ）

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    Publishing type：Research paper (scientific journal)   International / domestic magazine：Domestic journal  

    BACKGROUND: T50 calciprotein crystallization test (serum calcification propensity, T50) is a blood test which assesses the resistance of the serum to calcification stress in vitro. Because of its limited availability in clinical practice of chronic kidney disease, we aimed to develop equations for estimated T50 (eT50). METHODS: This was an observational study in 1,651 hemodialysis patients whose T50 was measured by the method Pasch et al. The data sets were divided into two groups for the derivation (N = 1,003) and validation (N = 648) of the equations. Logarithmically transformed values of measured T50 were regressed by relevant variables selected from 36 candidates based on the Akaike's Information Criteria. RESULTS: Because the initial model A included 19 variables, we developed simpler models B and C with 10 and 5 variables, respectively, for clinical use. All these models included serum phosphate, magnesium, sodium, chloride, and total ion binding capacity. When these equations were validated, the intercept, slope, and R2 values were 1.130, 0.770, 0.596 for model A, 1.093, 0.782, and 0.597 for model B, and 0.979, 0.806, and 0.573 for model C, respectively. Multivariable-adjusted Fine-Gray analysis showed that a lower eT50 value by model A, B, or model C was an independent predictor of a higher risk of new cardiovascular events in the total cohort as the measured T50 was. CONCLUSIONS: We developed three equations for eT50 from clinically available variables. These eT50 values may be useful if measured T50 is not available.

    DOI： 10.1007/s10157-025-02756-y

    PubMed

  • Effects of canagliflozin on kidney resistive index and oxygenation in patients with type 2 diabetes: findings obtained with ultrasonography and blood oxygenation level-dependent MRI.

    Hideki Uedono, Katsuhito Mori, Tsutomu Inoue, Yuri Machiba, Fumiyuki Morioka, Shinya Nakatani, Akihiro Tsuda, Hirokazu Okada, Masanori Emoto

    Frontiers in clinical diabetes and healthcare   7   1733806 - 1733806   2026

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    Publishing type：Research paper (scientific journal)   International / domestic magazine：International journal  

    BACKGROUND: Details regarding kidney-protective mechanisms of sodium-glucose cotransporter 2 (SGLT2) inhibitors remain unclear. High kidney resistive index (RI), evaluated by Doppler ultrasonography, and low T2* value, evaluated by blood oxygenation level-dependent (BOLD) magnetic resonance imaging (MRI) are risk factors for chronic kidney disease progression. In our previous study, canagliflozin (Cana) improved kidney oxygenation. In this post-hoc analysis, the effects of Cana on RI, as well as the correlation between changes in RI and T2* values, were evaluated. METHODS: Thirteen patients with type 2 diabetes (T2D) were analyzed. RI was determined at screening and on Day 5 (D5) following administration of Cana, while BOLD MRI was performed on D0, D1 (administration day), and D5. Cortical T2* values were evaluated using twelve-layer concentric object (TLCO) and region of interest (ROI) methods. Changes in RI and T2* values from D0 to D1 or D5 are expressed as ΔRI, ΔT2* (D1-D0), and Δ T2* (D5-D0), respectively. RESULTS: Cana significantly decreased RI, while ROI findings showed increased T2* (D0: 54.5 [50.8-55.5] vs D1: 56.2 [52.7-56.4], p = 0.003, r = 0.77; D0 vs D5: 54.5 [53.0-57.2], p = 0.080, r = 0.49). A significant negative correlation between ΔRI and ΔT2* (D1-D0) was shown by both TLCO (ρ = -0.621, p = 0.024) and ROI (ρ = -0.557, p = 0.048). CONCLUSION: Short-term Cana treatment improved RI and kidney oxygenation in patients with T2D. The inverse correlation found between changes in RI and T2* values suggest a mechanistic link between hemodynamic changes and improved oxygenation by SGLT2 inhibitors.

    DOI： 10.3389/fcdhc.2026.1733806

    PubMed

  • Guidelines for Nutritional Management of Sarcopenia and Frailty 2025. Guest Editor: Masafumi Kuzuya. This publication has been supported by The Japan Geriatrics Society and National Center for Geriatrics and Gerontology (NCGG) (Japan).

    Masafumi Kuzuya, Yoshihiko Kanno, Hidenori Arai, Shuhei Nishiguchi, Katsuya Iijima, Hiroyuki Umegaki, Shosuke Satake, Susumu Sato, Ken Shinmura, Ken Sugimoto, Hiroki Nishikawa, Katsuhito Mori, Yoshihiro Yoshimura, Hidetaka Wakabayashi, Aiko Inoue, Tatsuro Inoue, Hideki Uedono, Chiharu Uno, Masatsugu Okamura, Sayuri Ogawa, Masato Ogawa, Hiroyuki Kadoya, Kaori Kinoshita, Keitoku Kou, Yoichi Sato, Kensaku Shojima, Norio Suzuki, Bo-Kyung Son, Akihiro Tsuda, Kazuma Nagata, Fumihiko Nagano, Yukio Fujita, Atsushi Maeda, Masahiro Matsui, Ayaka Matsumoto, Kana Miyazaki, Takashi Mori, Mikako Yasuoka, Hiromitsu Yamazaki, Toshiya Yamamoto, Jiaqi Li, Weida Lyu

    Geriatrics & gerontology international   25 Suppl 2 ( S2 )   5 - 53   2025.12（ ISSN:14441586 ）

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    Publishing type：Research paper (scientific journal)   International / domestic magazine：Domestic journal  

    DOI： 10.1111/ggi.70275

    PubMed

  • Estimated T50 calciprotein crystallization test in patients undergoing hemodialysis: Osaka Dialysis Complication Study (ODCS)

    Shoji T.

    Clinical and Experimental Nephrology   29 ( 12 )   1850 - 1862   2025.12（ ISSN:13421751 ）

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  • 血液透析患者における血漿カルプロテクチンと腎動脈下大動脈石灰化との関連(The Association between Plasma Calprotectin and Infra-renal Aortic Calcification in Patients Undergoing Hemodialysis)

    Sone Kazuma, Mori Katsuhito, Uedono Hideki, Shoji Shigeichi, Yamakawa Tomoyuki, Emoto Masanori

    Osaka City Medical Journal   71 ( 2 )   73 - 82   2025.12（ ISSN:0030-6096 ）

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    血管石灰化は促進因子と抑制因子のバランスによって能動的に調節され、慢性腎臓病患者および血液透析(HD)患者において心血管疾患イベントや死亡率と強く関連している。炎症促進因子であるカルプロテクチンは、CKD患者で血管石灰化を促進する可能性が示唆されているが、HD患者における血管石灰化との関連は明らかでない。本研究では、HD患者119例(年齢中央値74歳、男性72例、女性47例)を対象に血液採取と腹部CT撮像を行い、血漿カルプロテクチン濃度と大動脈石灰化との関連を検討した。大動脈石灰化はマルチスライスCTを用いてAgatstonスコアで定量し、血漿カルプロテクチン濃度はELISAキットで測定した。血漿カルプロテクチン濃度中央値は1089ng/mLであった。Spearmanの順位相関では、カルプロテクチンと大動脈石灰化との間に有意な相関は認められず、重回帰分析でもカルプロテクチンは大動脈石灰化の独立した寄与因子ではなかった。以上より、HD患者において血漿カルプロテクチン濃度と大動脈石灰化との有意な関連は認められなかった。

  • 血液透析施行患者における推定T50カルシウムタンパク質石灰化検査　Osaka Dialysis Complication Study(ODCS)(Estimated T50 calciprotein crystallization test in patients undergoing hemodialysis: Osaka Dialysis Complication Study(ODCS))

    Shoji Tetsuo, Kabata Daijiro, Nagakura Yu, Nakatani Shinya, Uedono Hideki, Nagata Yuki, Fujii Hisako, Mori Katsuhito, Imanishi Yasuo, Morioka Tomoaki, Emoto Masanori

    Clinical and Experimental Nephrology   29 ( 12 )   1850 - 1862   2025.12（ ISSN:1342-1751 ）

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    臨床的に利用可能な血清石灰化傾向T50推定式の開発を試みた。Osaka Dialysis Complication Study)の血液透析患者1651例(男性1040例、女性611例、年齢中央値50歳)を第2群に分け、導出データセット群1003例でT50推定式(eT50)を開発し、他群648例で検証を行った。さらに全集団を対象に、測定T50(mT50)およびeT50値を用いて、全死因死亡率および新規心血管疾患のリスクを予測した。eT50は3種の式を開発した。モデルAでは測定されたT50の対数変換値を、赤池情報量規準に基づき選択した36個の候補変数から適切な変数19種を選択し、モデルBとモデルCは臨床現場でより簡便な式とするため変数をそれぞれ10個と5個に制限して開発した。mT50とeT50の一致度を傾き、切片、R2で評価した結果、モデルAではそれぞれ1.130、0.770、0.596、モデルBでは1.093、0.782、0.597、モデルCでは0.979、0.806、0.573であった。多変量調整Fine-Gray解析では、各モデルによるeT50値の低下が、新規心血管イベントリスク上昇の独立予測因子であることが示された。これらeT50値は、mT50値が入手できない場合に有用と思われた。

  • 特集 腎疾患治療薬　フロントライン 各論 第1章　腎疾患患者への薬の使い方 9.糖尿病性腎症:GLP-1受容体作動薬

    上殿 英記

    腎と透析   99 ( 7 )   70 - 75   2025.11（ ISSN:03852156 ）

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  • 【腎疾患治療薬　フロントライン】(第1章)腎疾患患者への薬の使い方　糖尿病性腎症　GLP-1受容体作動薬

    上殿 英記

    腎と透析   99 ( 増刊 )   70 - 75   2025.11（ ISSN:0385-2156 ）

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    ＜文献概要＞1はじめに　インクレチンは腸管内分泌細胞から分泌され,血糖依存的に膵β細胞からのインスリン分泌を促進するペプチドである。代表的なインクレチンには,glucose-dependent insulinotropic polypeptide(GIP)およびglucagon-like peptide-1(GLP-1)があり,これらに基づくインクレチン関連薬が実臨床で広く使用されている。Dipeptidyl peptidase-4(DPP-4)阻害薬は,GLP-1の分解を抑制することで内因性のGLP-1濃度を生理的範囲内で上昇させる一方,GLP-1受容体作動薬はDPP-4に抵抗性を有する構造により,高濃度のGLP-1作用を発揮する。

  • 血液透析中に発症したポリビニルピロリドン(PVP)によるアナフィラキシーの一例

    林 瑞紀, 福田 裕介, 森岡 史行, 橋本 真, 上殿 英記, 仲谷 慎也, 津田 昌宏, 立石 悠, 森 克仁, 繪本 正憲

    日本腎臓学会誌   67 ( 6-W )   990 - 990   2025.09（ ISSN:0385-2385 ）

  • 酵素補充療法中にマルベリー小体を検出し腎生検を施行したFabry病の一例

    好本 雅也, 津田 昌宏, 森岡 史行, 曽根 一真, 堀田 純子, 上殿 英記, 仲谷 慎也, 瀬戸 俊之, 森 克仁, 繪本 正憲

    日本腎臓学会誌   67 ( 6-W )   1015 - 1015   2025.09（ ISSN:0385-2385 ）

  • 特集 CKD栄養管理のための最新情報 CKDの栄養管理におけるリン

    上殿 英記, 森 克仁

    臨床栄養   147 ( 2 )   191 - 196   2025.08（ ISSN:04851412 ）

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  • 【CKD栄養管理のための最新情報】CKDの栄養管理におけるリン

    上殿 英記, 森 克仁

    臨床栄養   147 ( 2 )   191 - 196   2025.08（ ISSN:0485-1412 ）

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    ＜文献概要＞コレがわかる!　CKDでは高リン血症対策が必須であり,食事療法は重要な位置を占めます.本稿では,食品中のリンの特徴を考慮した栄養学的なリン管理について解説します.

  • Pharmacological HIF-PH Inhibition Suppresses Myoblast Differentiation Through Continued HIF-1α Stabilization.

    Yuya Miki, Akinobu Ochi, Hideki Uedono, Yoshinori Kakutani, Mitsuru Ichii, Yuki Nagata, Katsuhito Mori, Yasuo Imanishi, Tetsuo Shoji, Tomoaki Morioka, Masanori Emoto

    International journal of molecular sciences   26 ( 11 )   2025.06（ ISSN:16616596 ）

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    Publishing type：Research paper (scientific journal)   International / domestic magazine：International journal  

    Hypoxia-inducible factor prolyl hydroxylase (HIF-PH) inhibitors continually stabilize hypoxia-inducible factor-1α (HIF-1α). These inhibitors are effective in the clinical treatment of renal anemia. However, the effects of continued HIF-1α stabilization on skeletal muscle differentiation remain unclear. This study aimed to investigate the effects of continued HIF-1α stabilization on skeletal muscle differentiation using a HIF-PH inhibitor in both in vitro and in vivo models. We cultured mouse C2C12 myoblasts to differentiate into myotubes with or without FG-4592, a HIF-PH inhibitor. Additionally, we treated nine-week-old male C57BL/6 mice with either FG-4592 or vehicle via intraperitoneal injections three times a week for four weeks. In vitro, FG-4592 treatment stabilized HIF-1α continually. Morphological analysis revealed that 72 h FG-4592 treatment suppressed differentiation of C2C12 myoblasts into myotubes. This treatment decreased the gene and protein expression of MyoD and myogenin, reduced the protein expression of myosin heavy chain (MHC), and increased the gene and protein expression of myostatin. HIF-1α knockdown mitigated the decrease in MHC protein expression induced by FG-4592. In vivo, FG-4592 treatment increased HIF-1α protein expression and decreased MyoD, myogenin, and MHC protein expression in gastrocnemius muscle. These findings suggest that pharmacological HIF-PH inhibition suppresses myoblast differentiation through continued HIF-1α stabilization.

    DOI： 10.3390/ijms26115410

    PubMed

  • 2型糖尿病におけるT50 calciprotein crystallizationとfetuin-Aの役割の低下(T50 Calciprotein Crystallization and the Decreased Role of Fetuin-A in Type 2 Diabetes)

    Nagakura Yu, Shoji Tetsuo, Fukumoto Shinya, Uedono Hideki, Nakatani Shinya, Mori Katsuhito, Nagata Yuki, Imanishi Yasuo, Morioka Tomoaki, Watanabe Toshio, Emoto Masanori

    Journal of Atherosclerosis and Thrombosis   32 ( 6 )   763 - 774   2025.06（ ISSN:1340-3478 ）

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    2型糖尿病(T2D)がT50(血清石灰化傾向)へ及ぼす影響ならびにT2DとT50の関連におけるfetuin-Aの潜在的役割について、T2D群101例および非糖尿病群(対照群)101例を対象に検討した。fetuin-A濃度はT2D群で有意に高値であったが、T50については両群間で有意差はなかった。全例の解析において、T50はT2D、空腹時血漿ブドウ糖、HbA1c値とは関連しなかったが、血清中のfetuin-A濃度、リン濃度、カルシウム濃度と有意な関連を示した。T50とfetuin-A濃度の関連にT2Dによる効果修飾が認められた。各群の解析では、両群ともにT50とfetuin-Aは有意な正の関連を示したが、それらの関連はT2D群で弱かった。一方、T50とリン濃度およびカルシウム濃度の関連はT2D群でのみ有意であった。T50/fetuin-A比は対照群に比べT2D群で低値であり、空腹時血糖値およびHbA1c値と負の相関を示した。

  • 特集 CKD-MBD -進歩と革新 CKD-MBD関連因子 血清石灰化傾向(T50)

    上殿 英記, 仲谷 慎也, 庄司 哲雄

    腎と透析   98 ( 5 )   583 - 588   2025.05（ ISSN:03852156 ）

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  • 【CKD-MBD -進歩と革新】CKD-MBD関連因子　血清石灰化傾向(T50)

    上殿 英記, 仲谷 慎也, 庄司 哲雄

    腎と透析   98 ( 5 )   583 - 588   2025.05（ ISSN:0385-2156 ）

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    ＜文献概要＞はじめに　血管石灰化は慢性腎臓病(chronic kidney disease:CKD)患者に高頻度に認められ,予後悪化と関連する。この血管石灰化の進展には多くの因子が関与するが,リンがその中心的な役割を果たしているとされてきた。一方,肝で分泌される多機能糖蛋白質であるfetuin-Aは,石灰化抑制作用を有する。体内でリン・カルシウムの負荷がかかると,fetuin-Aはリン酸カルシウム結晶の析出を防ぐため,コロイド状のprimary CPP(calciprotein particles)を形成する。つまり,CPPは石灰化抑制作用の結果として生じた産物であると考えられるが,過剰な石灰化ストレスがかかると,ハイドロキシアパタイトへの結晶化が進み,secondary CPPへと成熟する。近年の研究から,このsecondary CPPが血管石灰化におけるリン毒性の主な実体であることが示されている。そのため,primary CPPからsecondary CPPへの成熟を抑制することが,石灰化の進行を防ぐのに重要であると考えられる。このprimary CPPからsecondary CPPへの変換を示す指標として,「血清石灰化傾向(T50)」が注目を集めており,T50をサロゲートマーカーとしたさまざまな臨床研究が行われている。本稿では,新たなリン毒性・石灰化ストレスの指標であるT50について概説する。

  • 2本の左腕頭静脈の狭窄による静脈高血圧症に対しステント留置が有効であった1例

    森岡 史行, 津田 昌宏, 上殿 英記, 仲谷 慎也, 長沼 俊秀, 森 克仁, 今西 康雄, 武本 佳昭, 内田 潤次, 繪本 正憲

    日本透析医学会雑誌   58 ( Suppl.1 )   1760 - 1760   2025.05（ ISSN:1340-3451 ）

  • 【糖尿病関連腎臓病-現在の課題とその対策-】糖尿病関連腎臓病における低栄養とその対策

    上殿 英記, 森 克仁

    糖尿病・内分泌プラクティスWeb   3 ( 2 )   2025 - 0019   2025.04

  • Definition of hyperfiltration taking into account age-related decline in renal function in kidney donor candidates with obesity and glucose tolerance disorder.

    Akihiro Tsuda, Katsuhito Mori, Hideki Uedono, Shinya Nakatani, Yuki Nagata, Masafumi Kurajoh, Shinsuke Yamada, Tomoaki Morioka, Eiji Ishimura, Junji Uchida, Masanori Emoto

    Hypertension research : official journal of the Japanese Society of Hypertension   48 ( 3 )   1115 - 1124   2025.03（ ISSN:09169636 ）

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    Publishing type：Research paper (scientific journal)   International / domestic magazine：International journal  

    The definition of hyperfiltration, the main pathogenesis in renal impairment in obesity and diabetes mellitus, is uncertain. Glomerular filtration rate (GFR) declines physiologically with aging, and there is inaccuracy in GFR in obesity due to body surface area (BSA) correction. Here, we defined hyperfiltration using GFR without BSA correction, but with inclusion of aging, and investigated hyperfiltration using this definition and absolute GFR > 125 mL/min. The subjects were 180 kidney donor candidates (56.4 ± 11.3 years old, 79 males). GFR was evaluated using inulin clearance. A two-hour 75-g oral glucose tolerance test was also performed. The subjects were divided into four groups with and without a combination of glucose tolerance disorder and BMI. Normal glucose tolerance (NGT) and BMI < 25 kg/m2 were defined as normal, and hyperfiltration was defined as the upper 95% confidence interval of the relationship of aging and GFR in normal cases, and compared with GFR > 125 mL/min. RESULTS: GFR without BSA correction and UAE in non-NGT subjects with obesity were higher than in other groups, but GFR with BSA correction did not show this relationship. In multiple regression analysis, BMI was independently associated with GFR without BSA correction, but not with BSA correction. Aging was consistently associated with GFR. The prevalence of hyperfiltration by our definition (GFR = -0.883 × Age + 167.398) was significantly higher than that using GFR > 125 mL/min (P < 0.0001). Hyperfiltration in obesity and/or glucose tolerance disorder should be evaluated using GFR without BSA correction and including the decline of GFR due to aging.

    DOI： 10.1038/s41440-024-02020-y

    PubMed

  • 肥満および耐糖能障害を有する腎移植ドナー候補者における加齢による腎機能低下を考慮した過剰濾過の定義(Definition of hyperfiltration taking into account age-related decline in renal function in kidney donor candidates with obesity and glucose tolerance disorder)

    Tsuda Akihiro, Mori Katsuhito, Uedono Hideki, Nakatani Shinya, Nagata Yuki, Kurajoh Masafumi, Yamada Shinsuke, Morioka Tomoaki, Ishimura Eiji, Uchida Junji, Emoto Masanori

    Hypertension Research   48 ( 3 )   1115 - 1124   2025.03（ ISSN:0916-9636 ）

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    糸球体濾過量(GFR)から過剰濾過を判定する閾値について検討した。腎移植ドナー候補者180名を耐糖能異常と肥満の有無で4群に分け、実測GFR、尿アルブミン排泄量(UAE)を比較した。耐糖能異常の肥満群は、体表面積(BSA)未補正GFRとUAEが他群より高く、過剰濾過の存在が示唆されたが、BSA補正GFRには差がなかった。3通りの重回帰モデルにおいて、年齢はBSA未補正および補正後のGFRと関連したが、BMIはBSA未補正GFRとのみ関連を示した。耐糖能正常の非肥満群における年齢とBSA未補正GFRとの関係の95%信頼区間上限値を過剰濾過の閾値と定義し、その計算式を導出した。既報の閾値(実測GFR>125mL/min)で過剰濾過に該当せず、本式で過剰濾過とされた患者(2名)はいずれも高齢であった。肥満者や耐糖能異常患者の過剰濾過の評価はBSA未補正GFRで行い、加齢によるGFR低下を考慮する必要があると考えられた。

  • An autopsy-proven case of normotensive scleroderma renal crisis with refractory pleuroperitoneal effusion.

    2025

  • Associations of Cognitive Function with Serum Magnesium and Phosphate in Hemodialysis Patients: A Cross-Sectional Analysis of the Osaka Dialysis Complication Study (ODCS).

    Tetsuo Shoji, Katsuhito Mori, Yu Nagakura, Daijiro Kabata, Kaori Kuriu, Shinya Nakatani, Hideki Uedono, Yuki Nagata, Hisako Fujii, Yasuo Imanishi, Tomoaki Morioka, Masanori Emoto

    Nutrients   16 ( 21 )   2024.11

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    Publishing type：Research paper (scientific journal)   International / domestic magazine：International journal  

    Cognitive impairment and dementia are common in patients with chronic kidney disease, including those undergoing hemodialysis. Since magnesium and phosphate play important roles in brain function and aging, alterations in these and other factors related to bone mineral disorder (MBD) may contribute to low cognitive performance in patients on hemodialysis. This cross-sectional study examined the associations between cognitive function and MBD-related factors among 1207 patients on maintenance hemodialysis. Cognitive function was assessed by the Modified Mini-Mental State examination (3MS). The exposure variables of interest were serum magnesium, phosphate, calcium, calcium-phosphate product, intact parathyroid hormone, fetuin-A, T50 calciprotein crystallization test, use of phosphate binders, use of cinacalcet, and use of vitamin D receptor activators. Multivariable-adjusted linear regression models were used to examine the associations between 3MS and each of the exposure variables independent of 13 potential non-mineral confounders. We found that lower 3MS was associated with lower serum magnesium, lower phosphate, lower calcium-phosphate product, and nonuse of phosphate binders. These results suggest that magnesium and phosphate play potentially protective roles against cognitive impairment in this population.

    DOI： 10.3390/nu16213776

    PubMed

  • Association Between Plasma Aldosterone Concentration and Intraglomerular Hemodynamics in Primary Aldosteronism.

    Hideki Uedono, Masafumi Kurajoh, Norikazu Toi, Akihiro Tsuda, Kento Shinmaru, Yuya Miki, Shinya Nakatani, Yuki Nagata, Tomoaki Morioka, Katsuhito Mori, Yasuo Imanishi, Masanori Emoto

    American journal of hypertension   37 ( 10 )   801 - 809   2024.10（ ISSN:08957061 ）

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    Publishing type：Research paper (scientific journal)   International / domestic magazine：International journal  

    BACKGROUND: In primary aldosteronism (PA), aldosterone could affect glomerular hemodynamics by elevating renal vascular resistance and glomerular capillary pressure. However, the relationship between plasma aldosterone concentrations (PAC) and glomerular hemodynamics including efferent arteriolar resistance (Re), and afferent arteriolar resistance (Ra) in humans is still unclear. The aim of this study was to investigate the relationships of PAC with intraglomerular hemodynamic parameters in patients with PA. METHODS: An observational study of glomerular hemodynamics was performed using simultaneous measurements of plasma clearance of para-aminohippurate and inulin (Cin; glomerular filtration rate (GFR)) in 17 patients with PA. Kidney function was evaluated by Cin, estimated GFR based on serum creatine (eGFRcre) and serum cystatin C (eGFRcys) and creatine clearance (Ccr). Intraglomerular hemodynamic parameters, including Re, Ra, and intraglomerular hydrostatic pressure (Pglo) were calculated using Gomez's formulae. RESULTS: In the 17 PA cases, PAC was significantly correlated with Cin (rho = 0.752, P = 0.001) and eGFRcys (rho = 0.567, P = 0.018), but was not correlated with eGFRcre and Ccr. PAC was also significantly correlated with Pglo, Re, and urinary protein/day (rho = 0.775, P = 0.0004, rho = 0.625, P = 0.009, and rho = 0.625, P = 0.007, respectively). Multivariable regression analysis showed that PAC was significantly associated with Cin and Re. In comparing aldosterone-producing adenoma (APA) and non-APA cases, Cin was significantly elevated in APA (P = 0.037), whereas eGFRcre, eGFRcys, and Ccr were not. Re tended to be higher in APA (P = 0.064). CONCLUSIONS: These results suggest high aldosterone causes glomerular hyperfiltration by constricting Re. Cin, but not eGFRcre and Ccr, may be useful for evaluating kidney function in PA.

    DOI： 10.1093/ajh/hpae071

    PubMed

  • Association between Serum Zinc and All-Cause Mortality in Patients Undergoing Maintenance Hemodialysis: The Osaka Dialysis Complication Study (ODCS).

    Shinya Nakatani, Tetsuo Shoji, Fumiyuki Morioka, Rino Nakaya, Mayuko Ueda, Hideki Uedono, Akihiro Tsuda, Tomoaki Morioka, Hisako Fujii, Hisako Yoshida, Katsuhito Mori, Masanori Emoto

    Nutrients   16 ( 19 )   2024.10

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    Publishing type：Research paper (scientific journal)   International / domestic magazine：International journal  

    BACKGROUND/OBJECTIVES: Zinc is an essential microelement, and its deficiency is common in patients undergoing hemodialysis. However, the association between serum zinc and mortality in these patients remains unclear. The aim of this study was to explore the possible association between serum zinc levels and all-cause mortality in prevalent patients with kidney failure on maintenance hemodialysis. METHODS: This was a prospective cohort study of maintenance hemodialysis patients followed up for 5 years. The key exposure was serum zinc level measured at baseline, and the outcome was all-cause mortality. Their association was analyzed using Cox proportional hazard models. RESULTS: Among 1662 eligible patients selected for this analysis, 468 (28%) died. Lower serum zinc levels were associated with a higher risk for mortality, independent of the major demographic factors and factors including mineral and bone disorder and renal anemia. However, this association was no longer significant when adjusted for serum albumin. Because there was a close correlation between serum zinc and albumin levels, we performed further analyses in which participants were categorized into four groups by median serum zinc (68 µg/dL) and albumin (3.7 g/dL) levels. In the lower serum albumin groups, risk of death was significantly higher in those with lower zinc than those with higher zinc levels, whereas such a difference was not significant in the high serum albumin groups. CONCLUSIONS: In patients undergoing maintenance hemodialysis with lower serum albumin levels, a lower serum zinc level was associated with a higher risk of mortality.

    DOI： 10.3390/nu16193270

    PubMed

  • Association Between Plasma Aldosterone Concentration and Intraglomerular Hemodinamics in Primary Aldosteronism

    HIdeki Uedono, Masafumi Kurajoh, Norikazu Toi, Akihiro Tsuda, Kento Shinmaru, Yuya Miki, Shinya Nakatani,Yuki Nagata, Tomoaki Morioka, Katsuhito Mori,Yasuo Imanishu, Masanori Emoto

    American journal of hypertension   37 ( 10 )   801 - 809   2024.09

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    Authorship：Lead author,　Corresponding author  

  • New-onset Kidney Biopsy-proven Membranous Nephropathy Induced End-stage Kidney Disease in a Living Donor

    Morioka Fumiyuki, Nakatani Shinya, Mori Katsuhito, Naganuma Toshihide, Yamasaki Takeshi, Uedono Hideki, Tsuda Akihiro, Ishimura Eiji, Uchida Junji, Emoto Masanori

    Internal Medicine   63 ( 18 )   2537 - 2541   2024.09（ ISSN:09182918 ） （ eISSN:13497235 ）

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    Publishing type：Research paper (scientific journal)   International / domestic magazine：Domestic journal  

    <p>Thirteen years after kidney donation, a 70-year-old man was referred to a nephrologist because of proteinuria. The serum creatinine, albumin, and urinary protein levels were 2.39 mg/dL, 3.0 g/dL, and 6.72 g/gCr, respectively. A kidney biopsy revealed thickening of the glomerular basement membrane with sub-epithelial deposits, suggesting membranous nephropathy. Considering the apparent interstitial fibrosis and diffuse glomerulosclerosis, supportive treatment was chosen. However, 11 months after the kidney biopsy, hemodialysis was required. The present case constitutes an important teaching point, as glomerular disease can occur in living donors and require careful and long-term medical checkup examinations. </p>

    DOI： 10.2169/internalmedicine.2814-23

    PubMed

    CiNii Research

  • 生体ドナーにおける腎生検で確認された膜性腎症による末期腎疾患の新規発症(New-onset Kidney Biopsy-proven Membranous Nephropathy Induced End-stage Kidney Disease in a Living Donor)

    Morioka Fumiyuki, Nakatani Shinya, Mori Katsuhito, Naganuma Toshihide, Yamasaki Takeshi, Uedono Hideki, Tsuda Akihiro, Ishimura Eiji, Uchida Junji, Emoto Masanori

    Internal Medicine   63 ( 18 )   2537 - 2541   2024.09（ ISSN:0918-2918 ）

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    症例は70歳男性で、タンパク尿のために来院した。患者は56歳時に腎移植ドナーとなっており、腎提供後6年は腎機能が維持されていたが、尿中タンパク陽性となり、アジルサルタン治療を開始していた。腎提供後13年時に紹介来院した際の血清クレアチニンは2.39mg/dL、推算糸球体濾過量は22.1mL/分/1.73m2、血清アルブミンは3.0g/dL、尿中タンパクは6.72g/gCrであった。入院3日目に開腹腎生検を行い、上皮下沈着物を伴う糸球体基底膜の肥厚が明らかとなり、ステージIV膜性腎症(MN)と診断した。胸腹部CTで悪性腫瘍は示されず、上下部消化管内視鏡検査でも明らかな消化管腫瘍は認められなかった。MNの二次性原因のスクリーニングは陰性であったことから、原発性MNと診断した。著明な間質線維化とび漫性糸球体硬化症を考慮し、慢性腎臓病に対する支持療法を行ったが、腎生検の11ヵ月後に血液透析を要する末期腎疾患となった。

  • 難治性胸腹水を呈し,Congo red染色が陽性となった正常血圧性強皮症腎クリーゼの剖検例

    上殿 英記, 曽根 一真, 好本 雅也, 森岡 史行, 仲谷 慎也, 津田 昌宏, 森 克仁, 繪本 正憲

    日本腎臓学会誌   66 ( 6-W )   1079 - 1079   2024.09（ ISSN:0385-2385 ）

  • 剖検にて免疫抑制薬関連リンパ増殖性疾患に伴う回腸穿孔と診断したANCA関連血管炎・RAの一例

    八幡 友貴, 仲谷 慎也, 加藤 雅大, 森岡 史行, 曽根 一真, 上殿 英記, 田中 さやか, 津田 昌宏, 森 克仁, 孝橋 賢一, 繪本 正憲

    日本腎臓学会誌   66 ( 6-W )   1099 - 1099   2024.09（ ISSN:0385-2385 ）

  • Dapagliflozin administration for 1 year promoted kidney enlargement in patient with ADPKD.

    Shinya Nakatani, Fumiyuki Morioka, Hideki Uedono, Akihiro Tsuda, Katsuhito Mori, Masanori Emoto

    CEN case reports   13 ( 4 )   284 - 289   2024.08

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    Publishing type：Research paper (scientific journal)   International / domestic magazine：Domestic journal  

    To date, there is insufficient evidence regarding use of sodium-glucose cotransporter-2 (SGLT2) inhibitors for patients with autosomal-dominant polycystic kidney disease (ADPKD), as such cases have been excluded from previous clinical trials exploring the kidney protection effects of such medications. Here, findings of an ADPKD patient who received dapagliflozin, a selective SGLT2 inhibitor, for 1 year are presented. A 38-year-old woman with a family history of ADPKD wished for treatment with dapagliflozin. After starting administration at 10 mg/day, total kidney volume (TKV) continued to increase, from 1641 to 1764 mL after 84 days and then to 2297 mL after 340 days. The estimated glomerular filtration rate (eGFR) was also decreased from 67.3 to 56.2 mL/min/1.73 m2, and then to 51.4 mL/min/1.73 m2 at those times. Immediately after discontinuation of dapagliflozin, TKV and eGFR were slightly improved to 2263 mL and 55.1 mL/min/1.73 m2, respectively. Following a review of basic research studies, we consider that increased intratubular urinary osmotic pressure, compensatory glucose reabsorption by sodium-glucose cotransporter-1 in the late proximal tubule, and hypertrophy shown in collected cells caused by increased vasopressin may be associated with ADPKD disease progression. Caution may be needed when administering dapagliflozin to patients with ADPKD.

    DOI： 10.1007/s13730-023-00840-4

    PubMed

  • Dapagliflozin administration for 1 year promoted kidney enlargement in patient with ADPKD(タイトル和訳中)

    Nakatani Shinya, Morioka Fumiyuki, Uedono Hideki, Tsuda Akihiro, Mori Katsuhito, Emoto Masanori

    CEN Case Reports   13 ( 4 )   284 - 289   2024.08

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    38歳女性。常染色体優性多発性嚢胞腎(ADPKD)の家族歴が母を含め4人存在し、本人も16歳時にADPKDと診断されていた。当院初診時点では高血圧症に対しオルメサルタン20mg/日を投与されていた。推算糸球体濾過量(eGFR)は74.6mL/分/1.73m2であった。総腎容積は、当院初診の3年前に行われたCT検査では1417mLであったが、今回は1641mLとなっていた。初診から9ヵ月後にはeGFRが67.3へ低下した。初診2年後に患者がナトリウム-グルコース共輸送体2(SGLT2)阻害薬での治療を希望したためダパグリフロジン10mg/日を開始した。開始3ヵ月後に評価した総腎容積は1764mLと著明に増加していたため、ダパグリフロジン中止およびトルバプタン治療を提案したが、却下された。以上より、ダパグリフロジン投与を1年間続けた。終了時点でのeGFRは51.4、総腎容積は2297mLであった。その後に患者はトルバプタン投与開始に同意し、1ヵ月後にはeGFRは55.1、総腎容積は2263mLに改善した。

  • ループス腎炎を合併した妊娠中の明らかな糖尿病患者の血糖管理を行い分娩に至った症例

    森本 万里, 越智 章展, 森 克仁, 吉田 潮, 中村 美之, 中舎 璃乃, 待場 優里, 上殿 英記, 栗原 康, 渡部 龍, 森岡 与明, 橋本 求, 橘 大介, 繪本 正憲

    糖尿病   67 ( Suppl.1 )   S - 300   2024.04（ ISSN:0021-437X ）

  • Differential associations of fetuin-A and calcification propensity with cardiovascular events and subsequent mortality in patients undergoing hemodialysis.

    Katsuhito Mori, Tetsuo Shoji, Shinya Nakatani, Hideki Uedono, Akinobu Ochi, Hisako Yoshida, Yasuo Imanishi, Tomoaki Morioka, Yoshihiro Tsujimoto, Makoto Kuro-O, Masanori Emoto

    Clinical kidney journal   17 ( 3 )   sfae042   2024.03（ ISSN:20488505 ）

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    Publishing type：Research paper (scientific journal)   International / domestic magazine：International journal  

    BACKGROUND: Fetuin-A inhibits precipitation of calcium-phosphate crystals by forming calciprotein particles (CPP). A novel T50 test, which measures transformation time from primary to secondary CPP, is an index for calcification propensity. Both lower fetuin-A and shorter T50 levels were associated with cardiovascular disease (CVD) risk in patients with chronic kidney disease (CKD). Extremely high risk for CVD death in advanced CKD patients consists of high-incidental CVD event and high mortality after CVD event. To date, it is unclear whether fetuin-A and/or T50 can equally predict each CVD outcome. METHODS: This prospective cohort study examined patients undergoing maintenance hemodialysis. The exposures were fetuin-A and T50. The outcomes of interests were new CVD events and subsequent deaths. The patients were categorized into tertiles of fetuin-A or T50 (T1 to T3). RESULTS: We identified 190 new CVD events during the 5-year follow-up of the 513 patients and 59 deaths subsequent to the CVD events during 2.5-year follow-up. A lower fetuin-A but not T50 was significantly associated with new CVD events [subdistribution hazard ratio (HR) 1.73, 95% confidence interval (CI) 1.15-2.61, P = .009 for T1 vs T3]. In contrast, a shorter T50 but not fetuin-A was a significant predictor of deaths after CVD events (HR 3.31, 95% CI 1.42-7.74, P = .006 for T1 + T2 vs T3). A lower fetuin-A was predictive of new CVD events, whereas a shorter T50 was more preferentially associated with subsequent death. CONCLUSION: These results indicate that fetuin-A and T50 are involved in cardiovascular risk in different manners.

    DOI： 10.1093/ckj/sfae042

    PubMed

  • Novel Digenic Variants in COL4A4 and COL4A5 Causing X-Linked Alport Syndrome: A Case Report.

    Hideki Uedono, Katsuhito Mori, Shinya Nakatani, Kohei Watanabe, Rino Nakaya, Fumiyuki Morioka, Kazuma Sone, Chie Ono, Junko Hotta, Akihiro Tsuda, Naoya Morisada, Toshiyuki Seto, Kandai Nozu, Masanori Emoto

    Case reports in nephrology and dialysis   14 ( 1 )   1 - 9   2024.01（ ISSN:2296-9705 ）

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    Publishing type：Research paper (scientific journal)   International / domestic magazine：International journal  

    INTRODUCTION: Alport syndrome (AS) is a hereditary, progressive kidney disease characterized by structural abnormalities and dysfunction of the glomerular basement membrane (GBM). AS is classified as X-linked, autosomal, and digenic. The number of cases of digenic AS has increased, but the genotype-phenotype correlation of patient with digenic AS is still unclear. Here, we present a case of digenic AS with novel digenic missense variants in COL4A4 (c.827G>C, p.Gly276Ala) and COL4A5 (c.4369G>C, p.Gly1457Arg). CASE PRESENTATION: The patient was a 29-year-old Japanese man suffering from persistent microscopic hematuria and proteinuria without kidney function impairment. Kidney biopsy showed focal interstitial foam cell infiltration, global and segmental glomerulosclerosis. Immunofluorescence staining for collagen IV α5 was almost negative in the GBM and Bowman's capsule. Electron microscopy revealed irregular thickening with lamellation and segmental thinning of the GBM. Clinical and pathological findings were consistent with AS. Comprehensive next-generation sequencing revealed a heterozygous missense variant in COL4A4 (c.827G>C, p.Gly276Ala) in exon 1 and a hemizygous missense variant in COL4A5 (c.4369G>C, p.Gly1457Arg) in exon 49 on the patient's paternal and maternal alleles, respectively. The same digenic variants were detected in his sister, and she also showed a similar phenotype. After treatment with angiotensin-converting enzyme inhibitors, proteinuria decreased from 2.3 to 1.1 g/g creatinine, but occult blood persisted. During follow-up, kidney function has been preserved. CONCLUSION: The novel genotype of our case provides more information on the genotype-phenotype correlation of digenic XLAS, although long-term follow-up is required. The findings in the present case also indicate the importance of genetic tests for family members of a patient diagnosed with digenic AS.

    DOI： 10.1159/000535493

    PubMed

  • 特集 透析診療のすべて Part 2　透析管理の基本と原則 5.血液透析患者におけるドライウェイト(DW)のマネジメント-数値の背景にあるDWの考え方を知る

    上殿 英記, 森岡 史行

    Hospitalist   11 ( 2 )   309 - 318   2024.01（ ISSN:21880409 ） （ eISSN:21896429 ）

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  • 【透析診療のすべて】(Part 2)透析管理の基本と原則　血液透析患者におけるドライウェイト(DW)のマネジメント　数値の背景にあるDWの考え方を知る

    上殿 英記, 森岡 史行

    Hospitalist   11 ( 2 )   309 - 318   2024.01（ ISSN:2188-0409 ）

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    ＜文献概要＞血液透析患者において安全に透析治療を行うことは,生命予後,QOLの面から非常に重要である。透析中の過度な血圧変動をなくし,体内水分量を至適な状態にすることを目標とするが,体重管理にゴールドスタンダードは存在せず,透析医療に携わる医療者にとって頭を悩ませる問題となっている。本稿では,筆者が実臨床で体重管理に難渋した以下のような症例をふまえ,血液透析患者におけるドライウェイト(DW)の定義や設定方法について,エビデンスを交えて考察する。またDW維持のための方法とともに,速すぎる限外濾過速度の弊害についても概説する。

  • Associations of Cognitive Function with Serum Magnesium and Phosphate in Hemodialysis Patients: A Cross-Sectional Analysis of the Osaka Dialysis Complication Study (ODCS). OA

    Shoji T, Mori K, Nagakura Y, Kabata D, Kuriu K, Nakatani S, Uedono H, Nagata Y, Fujii H, Imanishi Y, Morioka T, Emoto M.

    2024

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  • Association Between Plasma Aldosterone Concentration and Intraglomerular Hemodynamics in Primary Aldosteronism

    Uedono H, Kurajoh M, Toi N, Tsuda A, Shinmaru K, Miki Y, Nakatani S, Nagata Y, Morioka T, Mori K, Imanishi Y, Emoto M.

    Am J Hypertens.   2024

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    Authorship：Lead author,　Corresponding author  

  • Novel Digenic Variants in COL4A4 and COL4A5 Causing X-Linked Alport Syndrome: A Case Report OA

    2024

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  • Effects of canagliflozin on kidney oxygenation evaluated using blood oxygenation level-dependent MRI in patients with type 2 diabetes.

    Katsuhito Mori, Tsutomu Inoue, Yuri Machiba, Hideki Uedono, Shinya Nakatani, Masahiro Ishikawa, Satsuki Taniuchi, Yutaka Katayama, Akira Yamamoto, Naoki Kobayashi, Eito Kozawa, Taro Shimono, Yukio Miki, Hirokazu Okada, Masanori Emoto

    Frontiers in endocrinology   15   1451671 - 1451671   2024（ ISSN:1664-2392 ）

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    Publishing type：Research paper (scientific journal)   International / domestic magazine：International journal  

    BACKGROUND: Recent clinical studies suggest protective effects of SGLT2 inhibitors on kidney disease outcome. Chronic hypoxia has a critical role in kidney disease development, thus we speculated that canagliflozin, an SGLT2 inhibitor, can improve kidney oxygenation. METHODS: A single-arm study was conducted to investigate the effects of canagliflozin on T2* value, which reflects oxygenation level, in patients with type 2 diabetes (T2D) using repeated blood oxygenation level-dependent MRI (BOLD MRI) examinations. Changes in cortical T2* from before (Day 0) to after single-dose treatment (Day 1) and after five consecutive treatments (Day 5) were evaluated using 12-layer concentric objects (TLCO) and region of interest (ROI) methods. RESULTS: In the full analysis set (n=14 patients), the TLCO method showed no change of T2* with canagliflozin treatment, whereas the ROI method found that cortical T2* was significantly increased on Day 1 but not on Day 5. Sensitivity analysis using TLCO in 13 well-measured patients showed that canagliflozin significantly increased T2* on Day 1 with no change on Day 5, whereas a significant improvement in cortical T2* following canagliflozin treatment was found on both Day 1 and 5 using ROI. CONCLUSIONS: Short-term canagliflozin treatment may improve cortical oxygenation and lead to better kidney outcomes in patients with T2D.

    DOI： 10.3389/fendo.2024.1451671

    PubMed

  • T50 Calciprotein Crystallization and the Decreased Role of Fetuin-A in Type 2 Diabetes

    Nagakura Yu, Shoji Tetsuo, Fukumoto Shinya, Uedono Hideki, Nakatani Shinya, Mori Katsuhito, Nagata Yuki, Imanishi Yasuo, Morioka Tomoaki, Watanabe Toshio, Emoto Masanori

    Journal of Atherosclerosis and Thrombosis   advpub ( 0 )   763 - 774   2024（ ISSN:13403478 ） （ eISSN:18803873 ）

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    Publishing type：Research paper (scientific journal)   International / domestic magazine：Domestic journal  

    <p> <b>Aim:</b> Patients with type 2 diabetes mellitus (T2D) are prone to develop vascular calcification. Fetuin-A protects against vascular calcification but it increases insulin resistance. T50 calciprotein crystallization (also called serum calcification propensity) is a novel marker of calcification stress. This study examined whether T2D affects T50 and the potential role of fetuin-A in the relationship between T2D and T50.</p><p><b>Methods:</b> This cross-sectional study included 101 individuals with T2D and 101 individuals without diabetes (controls). T50 and fetuin-A levels were measured using the established nephelometric method and an enzyme-linked immunosorbent assay, respectively.</p><p><b>Results:</b> Although fetuin-A levels were higher in the T2D group, T50 was not significantly different between the T2D and control groups. In multivariable-adjusted analyses of the total population, T50 was not independently associated with the presence of T2D, fasting plasma glucose, or HbA1c, whereas T50 was significantly associated with fetuin-A, phosphate, and calcium levels. The association between T50 and fetuin-A was modified by the presence of T2D. A subgroup analysis revealed that the positive association between T50 and fetuin-A was significant but smaller in the T2D group, and that the associations of T50 with serum phosphate and calcium were more evident in the T2D group. Additional analyses showed that T50/fetuin-A ratio was lower in the T2D group and that T50/fetuin-A ratio was inversely correlated with fasting glucose and HbA1c levels.</p><p><b>Conclusions:</b> T2D itself was not significantly associated with T50 but T2D modified the association between T50 and fetuin-A in favor of developing vascular calcification in T2D.</p>

    DOI： 10.5551/jat.65351

    PubMed

    CiNii Research

  • 慢性腎臓病における血管石灰化の病態と治療

    森　克仁、仲谷　慎也、上殿　英記、庄司　哲雄

    腎臓内科   17 ( 1 )   15 - 20   2023

  • T50(血清石灰化傾向) 石灰化ストレスの指標

    庄司 哲雄、仲谷　慎也、上殿　英記、永倉　優、永田　友貴、森岡　与明、森克仁、繪本　正憲

    腎臓内科   17 ( 1 )   104 - 111   2023

  • 糖尿病透析患者の全身管理を極める-専門医との連携を目指して-低血糖予防　どう防いだらいいか

    上殿　英記、森　克仁

    臨床透析   39 ( 1 )   37 - 42   2023

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    Authorship：Lead author  

  • 栄養評価と早期介入がポイント　ナースが防ぐ！透析患者の低栄養&食欲低下 クレアチニン・クレアチン産生速度

    上殿　英記、森　克仁

    透析ケア   29 ( 10 )   915 - 917   2023

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    Authorship：Lead author  

  • 血液浄化法に応じた食と栄養 　　通常血液透析

    上殿　英記、森　克仁

    臨床透析   39 ( 12 )   1377 - 1383   2023

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    Authorship：Lead author  

  • 17. Short-Term Dapagliflozin Administration in Autosomal Dominant Polycystic Kidney Disease-A Retrospective Single-Arm Case Series Study OA

    Morioka F, Nakatani S, Uedono H, Tsuda A, Mori K, Emoto M.

    J Clin Med.   12 ( 19 )   6341   2023

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  • Serum phosphate as an independent factor associated with cholesterol metabolism in patients undergoing hemodialysis: a cross-sectional analysis of the DREAM cohort OA

    Okute Y, Shoji T, Shimomura N, Tsujimoto Y, Nagata Y, Uedono H, Nakatani S, Morioka T, Mori K, Fukumoto S, Imanishi Y, Emoto M.

    Nephrol Dial Transplant.   31 ( 38 )   2023

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  • 【腎疾患治療薬update】腎疾患患者への薬の使い方 糖尿病腎臓病 GLP-1受容体作動薬

    上殿　英記、森　克仁

    腎と透析   91   102 - 106   2022

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    Authorship：Lead author  

  • 15. Nutritional Disorder Evaluated by the Geriatric Nutritional Risk Index Predicts Death After Hospitalization for Infection in Patients Undergoing Maintenance Hemodialysis OA

    Machiba Y, Mori K, Shoji T, Nagata Y, Uedono H, Nakatani S, Ochi A, Tsuda A, Morioka T, Yoshida H, Tsujimoto Y, Emoto M.

    J Ren Nutr.   32 ( 6 )   751 - 757   2022

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  • Seronegative Full-house Nephropathy with Crohn's Disease. OA

    2022

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  • 【加齢と腎泌尿器医療】高齢腎疾患患者の脂質管理

    上殿　英記、森　克仁

    腎と透析   90 ( 6 )   2021

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    Authorship：Lead author  

  • 多発性嚢胞腎に対するHIF-PH阻害薬の影響

    仲谷　慎也、上殿　英記、西出　孝蔵

    腎臓内科   14 ( 5 )   595 - 601   2021

  • Plasma Xanthine Oxidoreductase Activity Associated with Glycemic Control in Patients with Pre-Dialysis Chronic Kidney Disease OA

    Nakatani S, Ishimura E, Murase T, Nakamura T, Nakatani A, Toi N, Nishide K, Uedono H, Tsuda A, Kurajoh M, Yamada S, Mori K, Inaba M, Emoto M.

    Kidney Blood Press Res.   46 ( 4 )   475 - 483   2021

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  • Dissociation of Glycated Albumin and HbA1c Is Associated With a Decline of Glomerular Filtration Rate as Evaluated by Inulin Clearance

    Tsuda A, Mori K, Nakatani S, Machiba Y, Uedono H, Kurajoh M, Yamada S, Morioka T, Inaba M, Ishimura E, Uchida J, Emoto M.

    Diabetes Care.   44 ( 11 )   e188 - e189   2021

  • Effects of fetuin-A-containing calciprotein particles on posttranslational modifications of fetuin-A in HepG2 cells. Reviewed

    Uedono H, Mori K, Ochi A, Nakatani S, Miki Y, Tsuda A, Morioka T, Nagata Y, Imanishi Y, Shoji T, Inaba M, Emoto M.

    Scientific Reports   11   2021

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    Authorship：Lead author  

  • Cinacalcet may suppress kidney enlargement in hemodialysis patients with autosomal dominant polycystic kidney disease OA

    Nishide K, Nakatani S, Mori K, Morioka F, Machiba Y, Uedono H, Tsuda A, Inaba M, Ishimura E, Emoto M.

    Clin Exp Nephrol.   25 ( 3 )   261 - 269   2021

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  • Clinical and histopathological features of acute kidney injury in adult-onset minimal change nephrotic syndrome

    Nishide K, Nakatani S, Mori K, Morioka F, Machiba Y, Uedono H, Tsuda A, Inaba M, Ishimura E, Emoto M.

    Clin Exp Nephrol   2021

  • (CKD－MBD）Ca受容体作動薬と活性型VD製剤の選択と併用

    仲谷　慎也、上殿　英記、森　克仁、庄司哲雄

    腎臓内科   11 ( 5 )   2020

  • 【血糖コントロールの改善・安定化のコツとポイントにつながる(19)症例　とことんわかる血糖値】腎障害のある患者

    上殿　英記、森　克仁

    糖尿病ケア   174 - 178   2020

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    Authorship：Lead author  

  • Association between Serum Zinc and Calcification Propensity (T50) in Patients with Type 2 Diabetes Mellitus and In Vitro Effect of Exogenous Zinc on T50. OA

    Nakatani S, Mori K, Sonoda M, Nishide K, Uedono H, Tsuda A, Emoto M, Shoji T.

    Biomedicines   8 ( 9 )   337   2020

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  • Increased Glomerular Hydrostatic Pressure is Associated with Tubular Creatinine Reabsorption in Healthy Subjects OA

    Tsuda A, Ishimura E, Machiba Y, Uedono H, Nakatani S, Mori K, Uchida J, Emoto M.

    Kidney Blood Press Res.   45 ( 6 )   996 - 1008   2020

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  • Oncostatin M induces C2C12 myotube atrophy by modulating muscle differentiation and degradation.

    Miki Y, Morioka T, Shioi A, Fujimoto K, Sakura T, Uedono H, Kakutani Y, Ochi A, Mori K, Shoji T, Emoto M, Inaba M.

    Biochem Biophys Res Commun   27   951 - 956   2019

  • Association of Albuminuria With Intraglomerular Hydrostatic Pressure and Insulin Resistance in Subjects With Impaired Fasting Glucose and/or Impaired Glucose Tolerance

    Tsuda A, Ishimura E, Uedono H, Ochi A, Nakatani S, Morioka T, Mori K, Uchida J, Emoto M, Nakatani T, Inaba M.

    Diabetes Care.   41 ( 11 )   2414 - 2420   2018

  • Non-mercaptalbumin, Oxidized Form of Serum Albumin, Significantly Associated with Renal Function and Anemia in Chronic Kidney Disease Patients OA

    Nakatani S, Yasukawa K, Ishimura E, Nakatani A, Toi N, Uedono H, Tsuda A, Yamada S, Ikeda H, Mori K, Emoto M, Yatomi Y, Inaba M.

    Sci Rep.   14 ( 8 )   16796   2018

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  • U-shaped relationship between serum uric acid levels and intrarenal hemodynamic parameters in healthy subjects.

    Uedono H, Tsuda A, Ishimura E, Nakatani S, Kurajoh M, Mori K, Uchida J, Emoto M, Nakatani T, Inaba M.

    Am J Physiol Renal Physiol.   2017.06

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    Authorship：Lead author  

  • Comparison of the Estimated Glomerular Filtration Rate (eGFR) in Diabetic Patients, Non-Diabetic Patients and Living Kidney Donors OA

    Tsuda A, Ishimura E, Uedono H, Yasumoto M, Ichii M, Nakatani S, Mori K, Uchida J, Emoto M, Nakatani T, Inaba M.

    Kidney Blood Press Res.   41 ( 1 )   40 - 47   2016

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  • Relationship between serum uric acid levels and intrarenal hemodynamic parameters OA

    Uedono H, Tsuda A, Ishimura E, Yasumoto M, Ichii M, Ochi A, Ohno Y, Nakatani S, Mori K, Uchida J, Nakatani T, Inaba M.

    2015.06

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    Authorship：Lead author  

    Repository URL： http://hdl.handle.net/10466/0002016060

  • Significant association between glycemic status and increased estimated postglomerular resistance in nondiabetic subjects - study of inulin and para-aminohippuric acid clearance in humans OA

    3   e12321   2015

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Grant-in-Aid for Scientific Research

  • Calciprotein particles (CPP)のヘプシジンを介した腎性貧血への影響

    Grant-in-Aid for Early-Career Scientists  2027

  • Calciprotein particles (CPP)のヘプシジンを介した腎性貧血への影響

    Grant-in-Aid for Early-Career Scientists  2026

  • Calciprotein particles (CPP)のヘプシジンを介した腎性貧血への影響

    Grant-in-Aid for Early-Career Scientists  2025

Outline of education staff

  • 病棟および外来実習の医学生に対し、患者診察、問診を中心に指導を行っております。また、腎病理の解読方法についてスライドを使用して講義を行い、実際の医師国家試験の過去問などの演習を学生主体で進め、その指導を行っている。

Charge of on-campus class subject

  • 腎臓病態内科学（腎臓学-総論）

    2025   Intensive lecture   Graduate school

  • 腎臓病態内科学（病理・診断・治療セミナー）

    2025   Intensive lecture   Graduate school

  • 腎臓病態内科学（臨床研究-演習）

    2025   Intensive lecture   Graduate school

  • 腎臓病態内科学（基礎研究-演習）

    2025   Intensive lecture   Graduate school

Number of instructed thesis, researches

  • 2025

    Number of instructed the graduation thesis：1 

    [Number of instructed the Master's Program] (previous term)：1