Updated on 2026/03/08

写真a

 
NAKAKO SOICHIRO
 
Organization
Graduate School of Medicine Department of Clinical Medical Science Lecturer
School of Medicine Department of Medical Science
Title
Lecturer
Affiliation
Institute of Medcine
Affiliation campus
Nakamozu Campus,　Abeno Campus

Position

  • Graduate School of Medicine Department of Clinical Medical Science 

    Lecturer  2025.10 - Now

  • Graduate School of Medicine Department of Clinical Medical Science 

    Assistant Professor  2025.04 - 2025.09

  • School of Medicine Department of Medical Science 

    Lecturer  2025.10 - Now

  • School of Medicine Department of Medical Science 

    Assistant Professor  2025.04 - 2025.09

Degree

  • 博士(医学) （ Osaka Metropolitan University ）

  • 学士(医学) （ Osaka City University ）

Research Areas

  • Life Science / Hematology and medical oncology  / 血液悪性腫瘍, 同種造血幹細胞移植

  • Informatics / Life, health and medical informatics  / 医療AI

  • Life Science / Hematology and medical oncology  / 血液内科学、造血幹細胞移植、白血病

  • Informatics / Life, health and medical informatics  / 医療AI、医療DX

Research Interests

  • Hematopoietic cell transplantation

  • Leukemia

  • medical AI

Professional Memberships

  • Japanese Society of Laboratory Medicine

    2025.09 - Now

  • Japan Association for Medical Informatics

    2024.11 - Now

  • Japanese Association for Medical Artificial Intelligence

    2024.06 - Now

  • Japanese Society of Hematology

    2019.04 - Now

  • Japanese Society for Transplantation and Cellular Therapy

    2019.04 - Now

  • The Japanese Society of Internal Medicine

    2018.08 - Now   Domestic

  • The Japanese Society of Internal Medicine

    2018.08 - Now

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Job Career (off-campus)

  • Osaka Metropolitan University   Laboratory medicine and medical informatics

    2025.10 - Now

  • Osaka Metropolitan University Graduate School of Medicine   Laboratory Medicine and Medical Informatics

    2025.04 - 2025.09

  • Osaka Metropolitan University Hospital   Hematology

    2023.04 - 2024.03

Papers

  • Dynamic Relapse Prediction by Peripheral Blood WT1mRNA after Allogeneic Hematopoietic Cell Transplantation for Myeloid Neoplasms

    Nakako S.

    Transplantation and Cellular Therapy   30 ( 11 )   1088 - 1088.e12   2024.11（ ISSN:26666375 ）

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  • Successful treatment with mesenchymal stem cells for steroid-refractory late-onset idiopathic pneumonia syndrome following allogeneic hematopoietic cell transplantation.

    Soichiro Nakako, Hideo Koh, Nobuhiro Sogabe, Masatomo Kuno, Yosuke Makuuchi, Teruhito Takakuwa, Hiroshi Okamura, Mitsutaka Nishimoto, Yasuhiro Nakashima, Masayuki Hino, Hirohisa Nakamae

    Transplant immunology   86   102107 - 102107   2024.10（ ISSN:09663274 ）

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    Publishing type：Research paper (scientific journal)   International / domestic magazine：International journal  

    The reportedly poor outcome of late-onset idiopathic pneumonia syndrome (IPS) necessitates new approaches to its treatment. A 55-year-old man who had undergone allogeneic hematopoietic cell transplantation (allo-HCT) for myelodysplastic syndrome 1 year ago developed dyspnea with acute skin graft-versus-host disease (GVHD) flare-up while tapering immunosuppressive agents. He presented with acute respiratory distress syndrome with ground-glass opacities in the right upper and left lower lobes. All infectious tests, including multiplex polymerase chain reaction of nasal wash, were negative, and broad-spectrum antibiotic therapy was refractory. The patient was diagnosed with late-onset IPS and was refractory to methylprednisolone pulse therapy. He then showed a favorable response to mesenchymal stem cell (MSC) infusion. After eight infusions of MSCs, he had no IPS recurrence for over one year. Recently, preclinical studies have reported the potential therapeutic utility of MSC infusion for treating IPS, and our case supports its potential for treating late-onset IPS.

    DOI： 10.1016/j.trim.2024.102107

    PubMed

  • Effectiveness of venetoclax and azacytidine against myeloid/natural killer cell precursor acute leukemia.

    Ichiro Shiomi, Soichiro Nakako, Takahiko Nakane, Yumi Ogawa, Taku Araki, Yotaro Fujitani, Ryosuke Yamamura, Masayuki Hino, Hirohisa Nakamae

    International journal of hematology   119 ( 1 )   88 - 92   2024.01

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    Publishing type：Research paper (scientific journal)   International / domestic magazine：Domestic journal  

    Myeloid/natural killer (NK) cell precursor acute leukemia (MNKPL) is a rare leukemia subtype that possibly originates from precursor NK cells. The disease has a poor prognosis, and information on its treatment is lacking. We herein report the first case of a 46-year-old woman with MNKPL who was refractory to two lines of acute myeloid leukemia (AML)-type intensive chemotherapy but was successfully treated with venetoclax and azacytidine (VEN/AZA). She was diagnosed with MNKPL based on the conformations of immature lymphoblastoid morphology without myeloperoxidase reactivity that showed a CD7/CD33/CD34/CD56/HLA-DR positive phenotype and extramedullary regions. The disease was refractory to induction therapy with daunorubicin and cytarabine (DNR/Ara-C) and to reinduction therapy with mitoxantrone, etoposide, and cytarabine (MEC). After two lines of induction chemotherapy, massive pericardial and pleural effusion was found, and was suspected to be extramedullary lesions. The patient developed cardiac tamponade and required pericardiocentesis. Thus, VEN/AZA was administered as third-line therapy. After two cycles of VEN/AZA, the pericardial and pleural effusion disappeared, and complete remission was achieved. The patient received post-transplant cyclophosphamide-based haploidentical transplantation and has stayed relapse-free as of her last follow-up examination 2 years after diagnosis.

    DOI： 10.1007/s12185-023-03678-9

    PubMed

  • 骨髄性/ナチュラルキラー前駆細胞性急性白血病に対するベネトクラックスとアザシチジンの有効性(Effectiveness of venetoclax and azacytidine against myeloid/natural killer cell precursor acute leukemia)

    Shiomi Ichiro, Nakako Soichiro, Nakane Takahiko, Ogawa Yumi, Araki Taku, Fujitani Yotaro, Yamamura Ryosuke, Hino Masayuki, Nakamae Hirohisa

    International Journal of Hematology   119 ( 1 )   88 - 92   2024.01（ ISSN:0925-5710 ）

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    症例は46歳女性で、発熱、倦怠感、両側の頸部リンパ節腫脹で当院に入院した。CD7/CD33/CD34/CD56/HLA-DR陽性の表現型と髄外領域を示すミエロペルオキシダーゼ反応性を伴わない未熟なリンパ芽球様形態のコンフォメーションに基づき、骨髄性/ナチュラルキラー前駆細胞性急性白血病と診断した。ダウノルビシンとシタラビンによる導入療法と、ミトキサントロン、エトポシド、シタラビンによる再導入療法に難治性であった。導入化学療法を2ライン行った後、大量の心嚢液と胸水を認め、髄外病変が疑われた。心タンポナーデを発症し、心嚢穿刺を必要とした。そこで、三次治療としてベネトクラックス+アザシチジンが投与された。ベネトクラックス+アザシチジンを2サイクル投与した。その結果、心嚢水と胸水は消失し、完全寛解が得られた。その後、他院に転院し、移植後のシクロホスファミドをベースとしたハプロ同一移植を受け、診断から2年後の最終フォローアップ検査でも再発することなく生存した。

Presentations

  • Two-Stage Modeling for Dynamic Survival Prediction from Longitudinal Data

    Tomoya Ogawa, Masakazu Iwamura, Soichiro Nakako, Hiroshi Okamura, Akinori Nishikawa, Koichi Kise

    NeurIPS 2025 Workshop TS4H  2025.12 

  • Development and evaluation of a protein language model-based prediction model for acute graft-versus-host disease in HLA-mismatched hematopoietic stem cell transplantation

    Makoto Moriguchi, Soichiro Nakako, Hiroshi Okamura, Takakazu Kawase, Kyoko Fuse, Toshiki Terao, Kazuki Yoshimura, Noriko Doki, Takahiro Fukuda, Yuta Katayama, Tetsuya Eto, Kentaro Serizawa, Makoto Onizuka, Makoto Yoshimitsu, Yoshinobu Kanda, Ken Tabuchi, Yoshiko Atsuta, Junya Kanda, Makoto Murata

    67th ASH Annual Meeting and Exposition  2025.12 

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    Presentation type：Poster presentation  

  • 移植適応高リスクAML患者に対するCPX-351の単施設での使用経験

    西本 光孝, 藤井 弘輝, 南部 海, 高畑 将太, 芦田 郷夢, 上堂 智貴, 田中 静大, 川添 麻衣, 八重 秀克, 仲子 聡一郎, 森口 慎, 八木 尚子, 堤 美菜子, 中舎 洋輔, 井戸 健太郎, 堀内 美令, 久野 雅智, 長崎 譲慈, 岡村 浩史, 中嶋 康博, 中前 美佳, 中前 博久

    日本血液学会学術集会  2025.10  (一社)日本血液学会

  • Higher Graft CD4+ T Cell and B Cell Counts Reduce Relapse Risk in Haploidentical Peripheral Blood Stem Cell Transplantation with Posttransplant Cyclophosphamide

    Makoto Moriguchi, Seidai Tanaka, Soichiro Nakako, Kentaro Ido, Kazuki Sakatoku, Yosuke Nakaya, Yosuke Makuuchi, Masatomo Kuno, Mirei Horiuchi, Hiroshi Okamura, Mitsutaka Nishimoto, Yasuhiro Nakashima, Mika Nakamae, Masayuki Hino, Hirohisa Nakamae

    2025 Tandem Meetings of ASTCT and CIBMTR  2025.02 

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    Presentation type：Oral presentation (general)  

  • Comparison of Clinician and Machine Learning Predictions of Allo-HCT Prognosis: A Prospective Observational Study

    Soichiro Nakako, Hiroshi Okamura, Seidai Tanaka, Makoto Moriguchi, Kentaro Ido, Kazuki Sakatoku, Yosuke Nakaya, Yosuke Makuuchi, Masatomo Kuno, Mirei Horiuchi, Mitsutaka Nishimoto, Yasuhiro Nakashima, Mika Nakamae, Masayuki Hino, Hirohisa Nakamae

    2025 Tandem Meetings of ASTCT and CIBMTR  2025.02 

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    Presentation type：Poster presentation  

  • Development of a Health and Medical Information Tracking System for Post-Hematopoietic Stem Cell Transplantation Patients

    Keiko Ota, Hiroshi Okamura, Akinori Nishikawa, Saiko Kurosawa, Yoshiko Atsuta, Ken Tabuchi, Katsuto Takenaka, Toshihiro Miyamoto, Tatsuya Imi, Soichiro Nakako, Hirohisa Nakamae, Yukari Umemoto, Yosuke Makuuchi, Megumi Higashino, Takao Yoshida, Yutaro Konishi, Teruyuki Hirayama, Go Masuda, Eizen Kimura, Ayumi Shintani, Masayuki Hino

    2025 Tandem Meetings of ASTCT and CIBMTR  2025.02 

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    Presentation type：Poster presentation  

  • The Diagnostic Accuracy of the Refined EBMT Criteria 2023 for SOS

    Seidai Tanaka, Hiroshi Okamura, Soichiro Nakako, Makoto Moriguchi, Kentaro Ido, Kazuki Sakatoku, Yosuke Nakaya, Mirei Horiuchi, Yosuke Makuuchi, Masatomo Kuno, Mitsutaka Nishimoto, Yasuhiro Nakashima, Mika Nakamae, Masayuki Hino, Hirohisa Nakamae

    66th ASH Annual Meeting and Exposition  2024.12 

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    Presentation type：Poster presentation  

  • 同種移植患者におけるポサコナゾールとタクロリムスの投与経路による薬物相互作用

    久野 雅智, 康 秀男, 岡山 裕介, 安井 友佳子, 柴多 渉, 小山 翼, 西島 誠, 田中 静大, 出田 悠人, 向井 大貴, 川添 麻衣, 八重 秀克, 曽我部 信広, 仲子 聡一郎, 田添 久実代, 堀内 美令, 井戸 健太郎, 酒徳 一希, 幕内 陽介, 高桑 輝人, 岡村 浩史, 西本 光孝, 中嶋 康博, 中前 美佳, 安井 裕之, 掛屋 弘, 日野 雅之, 中前 博久

    日本血液学会学術集会  2024.10  (一社)日本血液学会

  • ポサコナゾールのday7濃度上昇は低K血症のリスク因子である

    岡山 裕介, 康 秀男, 久野 雅智, 安井 友佳子, 柴多 渉, 小山 翼, 西島 誠, 田中 静大, 出田 悠人, 向井 大貴, 川添 麻衣, 八重 秀克, 曽我部 信広, 仲子 聡一郎, 田添 久実代, 堀内 美令, 井戸 健太郎, 酒徳 一希, 幕内 陽介, 高桑 輝人, 岡村 浩史, 西本 光孝, 中嶋 康博, 中前 美佳, 安井 裕之, 掛屋 弘, 日野 雅之, 中前 博久

    日本血液学会学術集会  2024.10  (一社)日本血液学会

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