Updated on 2026/06/14

写真a

 
HASHIMOTO JUNICHI
 
Organization
Graduate School of Medicine Department of Basic Medical Science Assistant Professor
School of Medicine Department of Medical Science
Title
Assistant Professor
Affiliation
Institute of Medcine

Position

  • Graduate School of Medicine Department of Basic Medical Science 

    Assistant Professor  2026.04 - Now

  • School of Medicine Department of Medical Science 

    Assistant Professor  2026.04 - Now

Degree

  • 博士（保健学） （ Osaka Prefecture University ）

Research Areas

  • Life Science / Anatomy and histopathology of nervous system

  • Life Science / Neuroscience-general

Research Interests

  • sodium–potassium ATPase

  • synaptogenesis

  • Dendritic spine

  • Neural plasticity

  • Neurogenesis

  • Brain injury

  • cerebral infarction

Professional Memberships

  • The Japanese Association of Anatomists

    2026.01 - Now

  • The Japan Neuroscience Society

    2019.12 - Now

  • The Physiological Society of Japan

    2018.06 - Now

  • Japanese Physical Therapy Association

    2011.04 - Now

Papers

  • Co-administration of digoxin and trans-2-decenoic acid ethyl ester improves motor learning performance in mice. Reviewed

    Erika Fujita, Junpei Hadano, Junichi Hashimoto, Kazumasa Matsumoto-Miyai

    Behavioural brain research   508   116225 - 116225   2026.04（ ISSN:01664328 ）

    　More details

    Publishing type：Research paper (scientific journal)   International / domestic magazine：International journal  

    Neural circuit formation through synaptogenesis plays a crucial role in learning, memory, and the recovery of neural function following brain dysfunction. We previously reported that administering the low-dose cardiac glycoside digoxin, which activates brain Na/K-ATPase, promotes dendritic spine formation and improves motor learning. On the other hand, brain-derived neurotrophic factor (BDNF) is also involved in axon elongation, branching, attraction, and the maturation of dendritic spines. Since trans-2-decenoic acid ethyl ester (DAEE), an ester of medium-chain fatty acid with ten carbons, activates the signaling pathway downstream of BDNF-TrkB, co-administration of digoxin and DAEE could further improve motor learning. This study compared the effects of digoxin, DAEE, or both on motor learning performance and locomotor activity in mice. Digoxin improved early performance in the rotarod test without changing locomotor activity, but did not affect final performance. DAEE increased activity in the open-field test but had no effect on the running wheel and did not influence motor learning in the rotarod test. On the other hand, the combination of digoxin and DAEE improved performance on the rotarod test later in the study. These data indicate that combining digoxin with DAEE delays the peak effects of motor learning compared to digoxin monotherapy, a temporal shift that may offer therapeutic advantages in rehabilitation outcomes.

    DOI： 10.1016/j.bbr.2026.116225

    PubMed

  • Effects of Cardiac Glycoside Digoxin on Dendritic Spines and Motor Learning Performance in Mice Reviewed

    Junichi Hashimoto, Erika Fujita, Keisuke Tanimoto, Suzuo Kondo, Kazumasa Matsumoto-Miyai

    Neuroscience   541   77 - 90   2024.03（ ISSN:03064522 ） （ eISSN:1873-7544 ）

    　More details

    Publishing type：Research paper (scientific journal)   Kind of work：Joint Work  

    DOI： 10.1016/j.neuroscience.2024.01.018

    PubMed

  • Effects of arm and leg positions on lumbar multifidus muscle activity while on hands and knees or while standing Reviewed

    Yasuhiro Mitani, Masaru Hanafusa, Junichi Hashimoto, Ryuta Inada, Hitoshi Koda

    Journal of Physiological Anthropology   41 ( 1 )   2022.12（ ISSN:1880-6791 ） （ eISSN:1880-6805 ）

    　More details

    Publishing type：Research paper (scientific journal)  

    DOI： 10.1186/s40101-022-00279-z

    PubMed

  • The nitric oxide-cyclic guanosine monophosphate pathway inhibits the bladder ATP release in response to a physiological or pathological stimulus Reviewed

    Eriko Okuyama, Masahito Kawatani, Junichi Hashimoto, Keisuke Tanimoto, Manabu Hashimoto, Kazumasa Matsumoto-Miyai

    Physiological Reports   9 ( 14 )   2021.07（ eISSN:2051-817X ）

    　More details

    Publishing type：Research paper (scientific journal)  

    DOI： 10.14814/phy2.14938

    PubMed

MISC

Presentations

  • Effects of digoxin and trans-2-decenoic acid ethyl ester on motor learning in mice

    Erika Fujita, Junichi Hashimoto, Junpei Hadano, Kazumasa Matsumoto-Miyai

    The 103rd Annual Meeting of the Physiological Society of Japan  2026.03 

    　More details

    Presentation type：Oral presentation (general)  

  • Dendritic spine formation promoted by the activation of Na/K ATPase activity facilitates motor learning performance in adult mice Domestic conference

    Junichi Hashimoto, Keisuke Tanimoto, Kazumasa Matsumoto-Miyai

    2021.07 

    　More details

    Presentation type：Poster presentation  

  • The regulation of Na/K ATPase activity facilitates dendritic spine formation and motor learning performance in adult mice Domestic conference

    Junichi Hashimoto, Keisuke Tanimoto, Kazumasa Matsumoto-Miyai

    2021.03 

    　More details

    Presentation type：Poster presentation  

  • Effects of cardiac glycoside digoxin on dendritic spine formation and learning performance in mice Domestic conference

    Junichi Hashimoto, Kazumasa Matsumoto-Miyai

    2020.07 

    　More details

    Presentation type：Poster presentation  

  • Digoxinによるシナプス新生と運動学習の促進 Domestic conference

    橋本遵一, 倉田夏芽, 竹田紗菜, 松本-宮井和政

    第24回 日本基礎理学療法学会学術大会  2019.11 

    　More details

    Presentation type：Poster presentation  

Grant-in-Aid for Scientific Research

  • Elucidation of the signaling pathways promoting recovery after brain injury and development of novel treatments

    Grant-in-Aid for Early-Career Scientists  2028

  • うつを制御する新たな神経メカニズムを基盤とする新規治療法確立のための基礎研究

    Grant-in-Aid for Scientific Research(C)  2028

  • Elucidation of the signaling pathways promoting recovery after brain injury and development of novel treatments

    Grant-in-Aid for Early-Career Scientists  2027

  • うつを制御する新たな神経メカニズムを基盤とする新規治療法確立のための基礎研究

    Grant-in-Aid for Scientific Research(C)  2027

  • Elucidation of the signaling pathways promoting recovery after brain injury and development of novel treatments

    Grant-in-Aid for Early-Career Scientists  2026

  • うつを制御する新たな神経メカニズムを基盤とする新規治療法確立のための基礎研究

    Grant-in-Aid for Scientific Research(C)  2026

  • Restoration of cognitive function by activating the synaptogenesis pathway

    Grant-in-Aid for Research Activity Start-up  2024

▼display all

Media Coverage

  • 大阪公立大、強心薬ジゴキシンが運動学習機能向上 Newspaper, magazine

    株式会社化学工業日報社  化学工業日報  朝刊第4面  2024.04

  • 脳障害後の運動機能、強心剤ジゴキシンで回復できる可能性－大阪公立大 Internet

    株式会社QLife  QLifePro  2024.02

  • 「薬剤の適用拡大」で運動学習能力向上 大阪公大研究員らが実証 医療費削減にも貢献 Internet

    株式会社官庁通信社  文教速報デジタル版  2024.02