Updated on 2026/07/28

写真a

 
NAKAMURA YUKI
 
Organization
Graduate School of Medicine Department of Basic Medical Science Assistant Professor
School of Medicine Department of Medical Science
Title
Assistant Professor
Affiliation
Institute of Medcine

Position

  • Graduate School of Medicine Department of Basic Medical Science 

    Assistant Professor  2026.04 - Now

  • School of Medicine Department of Medical Science 

    Assistant Professor  2026.04 - Now

Degree

  • 博士（医学） （ Kurume University ）

Research Areas

  • Life Science / Psychiatry

  • Life Science / Neuroscience-general

  • Life Science / Embryonic medicine and pediatrics

Research Interests

  • 神経発達症

  • 線条体

  • 記憶

  • 可塑性

  • 低酸素

  • ドパミンD1受容体

  • ドパミン

  • コカイン

  • アセチルコリン

Professional Memberships

  • 日本薬理学会

  • 日本小児科学会

Job Career (off-campus)

  • 大阪公立大学医学部 分子病態薬理学

    2026.04 - Now

  • Kurume University School of Medicine   Department of Pharmacology

    2021.12 - 2026.03

Papers

  • Broad transcriptomic effects of Egr1 knockdown in the mouse nucleus accumbens core and its role in cocaine locomotor sensitization Reviewed

    Yuki Nakamura, Mélody Labarchède, Tiago Mendes, Yukari Nakamura, Sophie Longueville, Giulia Albertini, Lucile Marion-Poll, Louise-Laure Mariani, Denis Hervé, Anne Roumier, Jean-Antoine Girault

    Progress in Neuro-Psychopharmacology and Biological Psychiatry   144   111574 - 111574   2026.01（ ISSN:0278-5846 ）

    　More details

    Authorship：Lead author,　Corresponding author   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.pnpbp.2025.111574

  • Operant Training for Highly Palatable Food Alters Translating Messenger RNA in Nucleus Accumbens D2 Neurons and Reveals a Modulatory Role of Ncdn. Reviewed

    Enrica Montalban, Albert Giralt, Lieng Taing, Yuki Nakamura, Assunta Pelosi, Mallory Brown, Benoit de Pins, Emmanuel Valjent, Miquel Martin, Angus C Nairn, Paul Greengard, Marc Flajolet, Denis Hervé, Nicolas Gambardella, Jean-Pierre Roussarie, Jean-Antoine Girault

    Biological psychiatry   95 ( 10 )   926 - 937   2024.05

    　More details

    Publishing type：Research paper (scientific journal)   International / domestic magazine：International journal  

    BACKGROUND: Highly palatable food triggers behavioral responses including strong motivation. These effects involve the reward system and dopamine neurons, which modulate neurons in the nucleus accumbens (NAc). The molecular mechanisms underlying the long-lasting effects of highly palatable food on feeding behavior are poorly understood. METHODS: We studied the effects of 2-week operant conditioning of mice with standard or isocaloric highly palatable food. We investigated the behavioral responses and dendritic spine modifications in the NAc. We compared the translating messenger RNA in NAc neurons identified by the type of dopamine receptors they express, depending on the kind of food and training. We tested the consequences of invalidation of an abundant downregulated gene, Ncdn. RESULTS: Operant conditioning for highly palatable food increased motivation for food even in well-fed mice. In wild-type mice, free choice between regular and highly palatable food increased weight compared with access to regular food only. Highly palatable food increased spine density in the NAc. In animals trained for highly palatable food, translating messenger RNAs were modified in NAc neurons expressing dopamine D2 receptors, mostly corresponding to striatal projection neurons, but not in neurons expressing D1 receptors. Knockout of Ncdn, an abundant downregulated gene, opposed the conditioning-induced changes in satiety-sensitive feeding behavior and apparent motivation for highly palatable food, suggesting that downregulation may be a compensatory mechanism. CONCLUSIONS: Our results emphasize the importance of messenger RNA alterations in D2 striatal projection neurons in the NAc in the behavioral consequences of highly palatable food conditioning and suggest a modulatory contribution of Ncdn downregulation.

    DOI： 10.1016/j.biopsych.2023.08.006

    PubMed

Presentations

  • マウス側坐核のEgr1ノックダウンは、グルタミン酸作動性シナプス関連遺伝子を含めた多くの遺伝子発現を変化させ、コカイン誘発性運動感作の形成を阻害する

    中村 祐樹, 中村 有香里, Jean-Antoine Giraul, Denis Herv, 西 昭徳

    第77回日本薬理学会西南部会  2024.11 

    　More details

    Presentation type：Oral presentation (general)  

  • Functional changes in the basal ganglia-thalamo-cortical loops in L-DOPA-induced dyskinesia in a mouse model of unilateral Parkinson's disease.

    Tsurugizawa T., Nakamura Y., Nakamura Y., Pelosi A., Girault JA, Hervé D.

    FENS (Federation of European Neuroscience Societies) Forum 2024.  2024.06 

Grant-in-Aid for Scientific Research

  • ドパミンD1受容体を標的とした治療抵抗性うつ病新規治療法の開発基盤の確立

    Grant-in-Aid for Scientific Research(C)  2028

  • ドパミンD1受容体を標的とした治療抵抗性うつ病新規治療法の開発基盤の確立

    Grant-in-Aid for Scientific Research(C)  2027

  • ドパミンD1受容体を標的とした治療抵抗性うつ病新規治療法の開発基盤の確立

    Grant-in-Aid for Scientific Research(C)  2026

Charge of off-campus class subject

  • 臨床薬理

    2022
    -
    Now

  • 薬理学Ⅱ

    2022
    -
    Now

  • 臨床薬理学

    2022
    -
    Now