Updated on 2026/04/27

写真a

 
NISHIHARA SAEKA
 
Organization
Graduate School of Drug Discovery Sciences Department of Drug Discovery Sciences Assistant Professor
School of Science Department of Biological Chemistry
Title
Assistant Professor
Affiliation
Institute of Drug Discovery Science.

Position

  • Graduate School of Drug Discovery Sciences Department of Drug Discovery Sciences 

    Assistant Professor  2026.04 - Now

  • School of Science Department of Biological Chemistry 

    Assistant Professor  2026.04 - Now

Degree

  • 博士（薬学） （ Doshisha Women's College of Liberal Arts ）

Research Areas

  • Life Science / Pharmaceutical hygiene and biochemistry

Research Interests

  • 自然免疫

  • 抗菌ペプチド

Awards

  • 日本エンドトキシン・自然免疫研究会 優秀賞

    2024.11  

  • 第95回日本生化学会大会 若手優秀発表賞

    2022.11  

  • 日本薬学会 第142年会 ポスター発表の部 優秀発表賞

    2022.03  

  • 日本薬学会 第137年会 ポスター発表の部 優秀発表賞

    2017.03  

Papers

  • Lipopolysaccharide uptake is augmented in lipopolysaccharide-tolerant mouse macrophage-like cells via increased CD14 expression. Reviewed OA

    Saeka Nishihara, Takayuki Manabe, Mika Jouta, and Kiyoshi Kawasaki

    FEBS open bio   2026.04

    　More details

    Authorship：Lead author  

    DOI： 10.1002/2211-5463.70261

  • High amphipathicity of α-helical peptides enhances unmethylated CpG DNA-induced activation of mouse macrophage-like RAW264.7 cells Reviewed OA

    Saeka Nishihara, Nao Nakamura, and Kiyoshi Kawasaki

    Scientific Reports   14 ( 1 )   2024.07

    　More details

    Authorship：Lead author  

    DOI： 10.1038/s41598-024-67166-8

  • A tailored tetravalent peptide displays dual functions to inhibit amyloid β production and aggregation Reviewed

    Waka Sato, Miho Watanabe-Takahashi, Takuya Murata, Naoko Utsunomiya-Tate, Jun Motoyama, Masataka Anzai, Seiko Ishihara, Nanako Nishioka, Hina Uchiyama, Juri Togashi, Saeka Nishihara, Kiyoshi Kawasaki, Takashi Saito, Takaomi C. Saido, Satoru Funamoto, and Kiyotaka Nishikawa

    Communications Biology   6 ( 1 )   2023.04

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  • Relationship Between Affinity of Kn2-7 to CpG DNA and the Ability of Kn2-7 to Enhance Cellular Uptake of CpG DNA by RAW264.7 Cells Reviewed OA

    Saeka Nishihara, Mayu Wakita, and Kiyoshi Kawasaki

    BPB Reports   4 ( 2 )   55 - 58   2021.03

    　More details

    Authorship：Lead author  

    DOI： 10.1248/bpbreports.4.2_55

  • Enhanced cellular uptake of CpG DNA by α-helical antimicrobial peptide Kn2-7: Effects on macrophage responsiveness to CpG DNA Reviewed

    Saeka Nishihara, and Kiyoshi Kawasaki

    Biochemical and Biophysical Research Communications   530 ( 1 )   100 - 106   2020.09

    　More details

    Authorship：Lead author  

    DOI： 10.1016/j.bbrc.2020.07.013

MISC

Grant-in-Aid for Scientific Research

  • 感染症治療の新基盤となる、両親媒性抗菌ペプチドのCpG-DNA刺激応答増強機構の解明

    Grant-in-Aid for Early-Career Scientists  2025.04

Incentive donations / subsidies

  • 非メチル化CpG DNAの免疫刺激活性を増強する抗菌ペプチド

    日本私立学校振興・共済事業団   若手研究者奨励金  2024.05