Publishing type：Research paper (scientific journal)  

DOI： 10.1248/cpb.c26-00070

Publishing type：Research paper (scientific journal)  

Herein, we report the visible-light-induced upcycling of environmentally problematic perchloroethylene into valuable trichloroacetamides using chlorine dioxide (ClO ₂ ^• ). The reaction proceeds with stoichiometric amounts of reagents; under mild conditions, this enables...

DOI： 10.1039/d6cc00273k

<p>ポリケチドは生物活性天然物に広く見られる重要な化合物群であり，高度に官能基化された炭素骨格と連続した不斉中心を有するという構造的特徴がある．しかしながら，ポリケチド骨格の合成には，不斉アルドール反応やアリル化反応などを起点に多工程を要することが多く，合成効率の低さが課題となっていた．近年では，遷移金属触媒を用いたオレフィンとカルボニル化合物の不斉カップリング反応などが発展してきたものの，そのほとんどは2成分反応であり，複雑なポリケチド骨格を一挙に構築することは依然として困難であった．</p><p>なお，本稿は下記の文献に基づいて，その研究成果を紹介するものである.</p><p>1) Holmes H. <i>et al</i>., <i>Chem. Rev</i>., <b>118</b>， 6026-6052(2018). 2) Ma J.‐T. <i>et al</i>., <i>J. Am. Chem. Soc</i>., <b>147</b>, 45648-45659(2025). 3) Tahiri N. <i>et al</i>., <i>Angew. Chem. Int. Ed</i>., <b>59</b>, 7555-7560(2020).</p>

DOI： 10.14894/faruawpsj.62.7_678

CiNii Research

Publishing type：Research paper (scientific journal)  

DOI： 10.1021/acscatal.5c05961

Publishing type：Research paper (scientific journal)  

Amino-substituted benzofuran derivatives have attracted attention in recent years due to their remarkable biological activity.

DOI： 10.1039/d5qo01123j

property_type：Patent 

Application no：PCT/US2025/057641 

Publication no：WO2026122505A1 

The opioid crisis remains a significant public health challenge, with millions of individuals affected globally and a staggering number of fatalities resulting from opioid overdoses each year. The widespread use of opioids for pain management, combined with their high potential for misuse and dependence, has contributed to a growing epidemic with far-reaching consequences. Existing treatments, such as naloxone, have proven effective in reversing opioid-induced respiratory depression but are often limited by short durations of action, potential withdrawal effects, and reduced efficacy in certain circumstances. There is thus a need in the art for compounds and methods suitable for treating, preventing, and/or ameliorating opioid overdoses while reducing side effects and improving clinical outcomes. The present disclosure addresses this need.