Updated on 2024/06/10

写真a

 
HINO Masayuki
 
Organization
Graduate School of Medicine Department of Clinical Medical Science Professor
School of Medicine Department of Medical Science
Title
Professor
Affiliation
Institute of Medicine
Contact information
メールアドレス
Affiliation campus
Abeno Campus

Position

  • Graduate School of Medicine Department of Clinical Medical Science 

    Professor  2022.04 - Now

  • School of Medicine Department of Medical Science 

    Professor  2022.04 - Now

Degree

  • Doctor of Medicine ( The University of Tokyo )

Research Areas

  • Life Science / Hematology and medical oncology  / Hematology

  • Others / Others  / Laboratory medicine

Research Interests

  • 同種造血幹細胞移植

  • 白血病

  • 悪性リンパ腫

Research subject summary

  • hematopoietic stem cell transplantation, leukemia, lymphoma

Research Career

  • Hematopoietic stem cell transplantation

    stem cell, transplantation  Joint Research in Organization

    1992.04 - Now 

  • 臨床検査のニューテクノロジー

    Joint Research in Organization

    1998.04 - Now 

  • reproduction medicine

    mesenchymal stem cell  Joint Research in Organization

    1992.04 - Now 

  • Amplification and differentiation of isolated hematopoietic stem cell

    hematopoietic stem cell  Individual

    1991.04 - Now 

  • Therapy

    Joint Research in Japan

    1991.04 - Now 

  • Mechanism of leukemic cell differentiation

    leukemia, differentiation  Individual

    1987.04 - Now 

  • Cytokines and Cytokine receptors

    Cytokine, cytokine receptor  Individual

    1987.04 - Now 

Professional Memberships

  • 日本血液学会

      Domestic

  • 日本造血・免疫細胞療法学会

      Domestic

  • 日本内科学会

      Domestic

  • 日本臨床検査医学会

      Domestic

  • Japanese Society of Laboratory Hematology

      Domestic

  • 日本臨床腫瘍学会

      Domestic

  • 日本輸血細胞治療学会

      Domestic

  • American Society of Hematology

      Overseas

  • 日本感染症学会

      Domestic

  • 日本医学教育学会

      Domestic

  • 日本癌学会

      Domestic

  • 日本造血細胞移植学会

  • 日本輸血細胞治療学会

  • 日本血液学会

  • 日本臨床腫瘍学会

  • 日本癌学会

  • Japanese Society of Laboratory Hematology

  • 日本感染症学会

  • 日本医学教育学会

  • 日本内科学会

  • American Society of Hematology

  • 日本造血・免疫細胞療法学会

  • 日本臨床検査医学会

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Committee Memberships (off-campus)

  • 代議員   日本血液学会  

    1999 - Now 

  • 理事   日本造血・免疫細胞療法学会  

    2020 - 2024.03 

  • 評議員   日本造血・免疫細胞療法学会  

    2002 - Now 

  • 評議員   日本内科学会  

    2012 - 2024.03 

  • ドナー安全委員会副委員長   日本骨髄バンク  

    2016.04 - Now 

  • 理事   日本骨髄バンク  

    2022.06 - Now 

  • 地区代表協力医師   日本骨髄バンク  

    2017.04 - Now 

  • 危機管理担当医師   日本骨髄バンク  

    2017.10 - Now 

  • 評議員   日本臨床検査医学会  

    2014.01 - Now 

  • 評議員   日本検査血液学会  

    2000 - Now 

  • 理事   成人白血病治療共同研究機構  

    2019.07 - Now 

  • メンバー   日本赤十字社造血幹細胞移植支援システム開発プロジェクトチーム  

    2019.04 - Now 

  • 指定難病審査会委員   大阪市  

    2018.04 - Now 

  • 協議員   日本臨床腫瘍学会  

    2017.07 - Now 

  • 造血細胞移植登録一元管理委員会委員   日本造血細胞移植データセンター  

    2017.06 - Now 

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Job Career (off-campus)

  • Osaka Metropolitan University, Graduate School of Medicine   Hematology

    2022.04 - Now

  • Osaka Metropolitan University School of Medicine Department of Medical Science

    2022.04 - Now

  • Osaka Metropolitan University, Graduate School of Medicine   Hematology

    2022.04 - Now

  • Osaka City University, Graduate School of Medicine   Hematology

    2002 - 2021.03

  • 蒼龍会井上病院   内科   医師

    1990.09

  • 東京大学医科学研究所   細胞遺伝研究部   助手

    1989.10 - 1990.08

  • 東京大学医学部   第3内科学教室   研究生

    1987.04 - 1989.09

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Education

  • Osaka City University     Graduated/Completed

    1979.04 - 1985.03

Papers

  • Acquired angioedema as a late-onset complication after cord blood transplantation: a subtype of chronic graft-versus-host disease.

    Harada N, Moriguchi M, Hakui S, Takayanagi S, Izuta Y, Kizawa Y, Shiragami H, Nakamae H, Hino M, Mugitani A

    QJM : monthly journal of the Association of Physicians   2024.04

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  • Autotaxin is a potential predictive marker for the development of veno-occlusive disease/sinusoidal obstruction syndrome after allogeneic hematopoietic cell transplantation.

    Takemura K, Nakamae M, Okamura H, Sakatoku K, Ido K, Makuuchi Y, Kuno M, Takakuwa T, Hirose A, Nishimoto M, Nakashima Y, Koh H, Igarashi K, Kubota H, Hino M, Nakamae H

    Annals of hematology   2024.03( ISSN:0939-5555

  • Efficacy of elotuzumab for multiple myeloma deteriorates after daratumumab: a multicenter retrospective study.

    Nakamura N, Arima N, Takakuwa T, Yoshioka S, Imada K, Fukushima K, Hotta M, Fuchida SI, Kanda J, Uoshima N, Shimura Y, Tanaka H, Ohta K, Kosugi S, Yagi H, Yoshihara S, Yamamura R, Adachi Y, Hanamoto H, Shibayama H, Hosen N, Ito T, Shimazaki C, Takaori-Kondo A, Kuroda J, Matsumura I, Hino M, Kansai Myeloma Forum

    Annals of hematology   2024.03( ISSN:0939-5555

  • A comparison of long-term outcomes by donor type in the era of post-transplantation cyclophosphamide for aggressive adult T-cell leukemia/lymphoma.

    Hirose A, Koh H, Nakamae M, Nakashima Y, Nishimoto M, Okamura H, Makuuchi Y, Kuno M, Takakuwa T, Ido K, Sakatoku K, Hino M, Nakamae H

    Bone marrow transplantation   2024.02( ISSN:0268-3369

  • Lymphoproliferative disorder progressing after partial remission following immunosuppressive drugs withdrawal in a patient with rheumatoid arthritis.

    Fukumoto K, Watanabe R, Tsutsumi M, Takakuwa T, Miyamoto M, Hayashi N, Yamada S, Furumitsu Y, Hino M, Hashimoto M

    Modern rheumatology case reports   2024.02

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  • Comparison of long-term outcomes after first HLA-mismatched unrelated donor transplantation with single unrelated cord blood transplantation using reduced-intensity or reduced-toxicity conditioning.

    Kuno M, Koh H, Ido K, Sakatoku K, Makuuchi Y, Takakuwa T, Hirose A, Okamura H, Nishimoto M, Nakashima Y, Nakamae M, Hino M, Nakamae H

    Transplant immunology   82   101988   2024.02( ISSN:0966-3274

  • Pretransplant hepatomegaly is linked to relapse in patients with leukemia and myelodysplastic syndrome not in remission.

    Okayama Y, Harada N, Makuuchi Y, Kuno M, Takakuwa T, Okamura H, Hirose A, Nakamae M, Nishimoto M, Nakashima Y, Koh H, Hino M, Nakamae H

    International journal of hematology   2024.01( ISSN:0925-5710

  • Effectiveness of venetoclax and azacytidine against myeloid/natural killer cell precursor acute leukemia.

    Shiomi I, Nakako S, Nakane T, Ogawa Y, Araki T, Fujitani Y, Yamamura R, Hino M, Nakamae H

    International journal of hematology   119 ( 1 )   88 - 92   2024.01( ISSN:0925-5710

  • [Usefulness of web-based application for health surveys before and after peripheral blood stem cell harvest from healthy donors].

    Makuuchi Y, Okamura H, Umemoto Y, Nishikawa A, Tanaka R, Sato A, Sakatoku K, Ido K, Horiuchi M, Kuno M, Takakuwa T, Nishimoto M, Nakashima Y, Nakamae M, Yano S, Hino M, Nakamae H

    [Rinsho ketsueki] The Japanese journal of clinical hematology   65 ( 5 )   321 - 329   2024( ISSN:0485-1439

  • Invasive fungal infection caused by Blastobotrys mokoenaii in an immunocompromised patient with acute myeloid leukemia: A case report.

    Shiomi I, Makuuchi Y, Noura I, Kakuno S, Niki M, Kaimi Y, Ido K, Sakatoku K, Kuno M, Takakuwa T, Okamura H, Nishimoto M, Nakashima Y, Nakamae M, Kakeya H, Kohashi K, Hino M, Nakamae H

    Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy   2023.12( ISSN:1341-321X

  • Third HLA-haploidentical stem cell transplantation using post-transplant cyclophosphamide for relapsed acute leukemia.

    Harada N, Okamura H, Makuuchi Y, Kuno M, Takakuwa T, Nakamae M, Nishimoto M, Nakashima Y, Koh H, Hino M, Nakamae H

    Bone marrow transplantation   58 ( 12 )   1403 - 1405   2023.12( ISSN:0268-3369

  • Low- versus standard-dose post-transplant cyclophosphamide as GVHD prophylaxis for haploidentical transplantation.

    Fuji S, Sugita J, Najima Y, Konishi T, Tanaka T, Ohigashi H, Eto T, Nagafuji K, Hiramoto N, Matsuoka KI, Maruyama Y, Ota S, Ishikawa J, Kawakita T, Akasaka T, Kamimura T, Hino M, Fukuda T, Atsuta Y, Yakushijin K

    British journal of haematology   2023.11( ISSN:0007-1048

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  • Efficacy and Safety of Single-dose Pegfilgrastim for CD34+ Cell Mobilization in Healthy Volunteers: A Phase 2 Study.

    Goto H, Sugita J, Hasegawa Y, Hayasaka K, Sunagoya K, Hatase R, Nishida M, Ichihashi Y, Odera M, Senjo H, Yokoyama S, Ara T, Shiratori S, Endo T, Hino M, Maeda Y, Sawa M, Sato N, Teshima T

    Transplantation   2023.11( ISSN:0041-1337

  • Real-world data on induction therapy in patients with transplant-ineligible newly diagnosed multiple myeloma: retrospective analysis of 598 cases from Kansai Myeloma Forum.

    Shimura Y, Shibayama H, Nakaya A, Yamamura R, Imada K, Kaneko H, Hanamoto H, Fuchida SI, Tanaka H, Kosugi S, Kiyota M, Matsui T, Kanda J, Iida M, Matsuda M, Uoshima N, Shibano M, Karasuno T, Hamada T, Ohta K, Ito T, Yagi H, Yoshihara S, Shimazaki C, Nomura S, Hino M, Takaori-Kondo A, Matsumura I, Kanakura Y, Kuroda J

    International journal of hematology   118 ( 5 )   609 - 617   2023.11( ISSN:0925-5710

  • A Case of IgG1-Lambda Multiple Myeloma With Hyperviscosity Syndrome and Cryoglobulinemia: Identification of the Subclass Fraction by Immunoelectrophoresis and Immunofixation Electrophoresis.

    Tazoe K, Harada N, Takemura K, Nakamae M, Hino M

    Cureus   15 ( 11 )   e48253   2023.11( ISSN:2168-8184

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  • HLA-Haploidentical Peripheral Blood Stem Cell Transplantation with Post-Transplantation Cyclophosphamide versus HLA-Matched Unrelated Donor Transplantation for Myelodysplastic Syndrome.

    Nakaya Y, Koh H, Konuma T, Shimomura Y, Ishiyama K, Itonaga H, Hino M, Doki N, Nishida T, Ohigashi H, Matsuoka KI, Kanda Y, Maruyama Y, Sawa M, Eto T, Hiramoto N, Fukuda T, Atsuta Y, Nakamae H

    Transplantation and cellular therapy   2023.10( ISSN:26666367

  • The safety of the combination therapy of recombinant factor VIIa and plasma-derived factor VIIa and factor X for refractory hemorrhage in acquired hemophilia A.

    Okayama Y, Bingo M, Sakatoku K, Okamura H, Nanno S, Nishimoto M, Nakashima Y, Koh H, Hino M, Nakamae H

    Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis   34 ( 6 )   419 - 422   2023.09( ISSN:0957-5235

  • Sinusoidal obstruction syndrome associated with disseminated toxoplasmosis involving the liver after allogeneic hematopoietic stem cell transplantation: A case report(タイトル和訳中)

    Makuuchi Yosuke, Tanaka Sayaka, Koh Hideo, Niki Makoto, Norose Kazumi, Nakaya Yosuke, Ido Kentaro, Sakatoku Kazuki, Kuno Masatomo, Harada Naonori, Takakuwa Teruhito, Hirose Asao, Okamura Hiroshi, Nishimoto Mitsutaka, Nakashima Yasuhiro, Nakamae Mika, Hikosaka Kenji, Kakeya Hiroshi, Ohsawa Masahiko, Hino Masayuki, Nakamae Hirohisa

    Journal of Infection and Chemotherapy   29 ( 9 )   909 - 912   2023.09( ISSN:1341-321X

  • Ibrutinib Induces a Dramatic Improvement for Idiopathic Refractory Ascites Following Allogeneic Hematopoietic Cell Transplantation(タイトル和訳中)

    Tazoe Kumiyo, Nishimoto Mitsutaka, Yamamoto Akira, Makuuchi Yosuke, Kuno Masatomo, Okamura Hiroshi, Nakashima Yasuhiro, Tanaka Sayaka, Ohsawa Masahiko, Hino Masayuki, Nakamae Hirohisa

    Internal Medicine   62 ( 18 )   2737 - 2741   2023.09( ISSN:0918-2918

  • Sudden-onset gallbladder rupture due to Ceftriaxone-associated pseudolithiasis in a patient with acquired hemophilia A(タイトル和訳中)

    Harada Naonori, Shibano Ikumi, Mukai Daiki, Kizawa Yusuke, Shiragami Hiroshi, Takayanagi Shigenori, Hosaka Naoki, Mugitani Atsuko, Hino Masayuki

    Journal of Infection and Chemotherapy   29 ( 8 )   796 - 799   2023.08( ISSN:1341-321X

  • MRI findings of nelarabine-related rhabdomyolysis in a patient with refractory T-cell acute lymphoblastic leukemia.

    Mukai D, Harada N, Shibano I, Kizawa Y, Shiragami H, Mugitani A, Hino M

    EJHaem   4 ( 3 )   865 - 866   2023.08

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  • Sinusoidal obstruction syndrome associated with disseminated toxoplasmosis involving the liver after allogeneic hematopoietic stem cell transplantation: A case report Reviewed

    Makuuchi Y, Tanaka S, Koh H, Niki M, Norose K, Nakaya Y, Ido K, Sakatoku K, Kuno M, Harada N, Takakuwa T, Hirose A, Okamura H, Nishimoto M, Nakashima Y, Nakamae M, Hikosaka K, Kakeya H, Ohsawa M, Hino M, Nakamae H

    J Infect Chemother   2023.05

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.jiac.2023.05.009

  • Effect of graft cell dose on second transplantation from a haploidentical donor with post-transplantation cyclophosphamide for relapsed/refractory acute leukemia Reviewed

    Nakaya Y, Nakamae H, Harada N, Okamura H, Sakatoku K, Ido K, Makuuchi Y, Kuno M, Takakuwa T, Hirose A, Nakamae M, Nishimoto M, Nakashima Y, Koh H, Hino M

    2023.04

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    Authorship:Last author   Publishing type:Research paper (scientific journal)   International / domestic magazine:International journal  

    DOI: 10.1038/s41409-023-01986-6

  • Posttransplant cyclophosphamide contributes to the impairment of the graft-versus-leukemia effect and the amelioration of graft-versus-host disease with the suppression of alloreactive T cells in a murine stem cell transplant model Reviewed

    Makuuchi Y, Nakashima Y, Nishimoto M, Koh H, Hino M, Nakamae H.

    Exp Hematol   2023.04

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    Publishing type:Research paper (scientific journal)   International / domestic magazine:International journal  

    DOI: 10.1016/j.exphem.2023.04.003

  • Recapitulated late-onset inflammatory toxicities and progressive dysautonomia with persistence of central memory CD4+ chimeric antigen receptor T cells in a case of transformed follicular lymphoma: case report Reviewed

    Nishimoto M, Takakuwa T, Kuno M, Makuuchi Y, Okamura H, Nakashima Y, Koh H, Namba H, Itoh Y, Hino M, Nakamae H

    Acta Haematol.   2023.04

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    International / domestic magazine:International journal  

    DOI: 10.1159/000530743

  • Sudden-onset gallbladder rupture due to Ceftriaxone-associated pseudolithiasis in a patient with acquired hemophilia A Reviewed

    Harada N, Shibano I, Mukai D, Kizawa Y, Shiragami H, Takayanagi S, Hosaka N, Mugitani A, Hino M

    J Infect Chemother.   2023.04

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    Authorship:Last author   Publishing type:Research paper (scientific journal)   International / domestic magazine:International journal  

    DOI: 10.1016/j.jiac.2023.04.006.

  • Fulminant Metastatic Cellulitis Caused by Stenotrophomonas Maltophilia Infection and Subsequent Candida Parapsilosis Fungemia After Cord Blood Transplantation Reviewed

    Takagi I, Harada N, Niki M, Yamada K, Makuuchi Y, Kuno M, Takakuwa T, Okamura H, Nishimoto M, Nakashima Y, Koh H, Kakeya H, Hino M, Nakamae H

    Transplant Proc   55 ( 3 )   706 - 710   2023.04

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    International / domestic magazine:International journal  

    DOI: 10.1016/j.transproceed.2023.02.028

  • Two cases of eosinophilic gastrointestinal disorder due to newly appearing food allergies after cord blood transplantation Reviewed

    Harada N, Makuuchi Y, Kuno M, Takakuwa T, Okamura H, Nishimoto M, Nakashima Y, Koh H, Sakaida M, Tanaka S, Kuwae Y, Higashimori A, Tanaka F, Ohsawa M, Fujiwara Y, Hino M, Nakamae H

    Transpl Immunol   77   101781   2023.04

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    International / domestic magazine:International journal  

  • Rhinovirus/enterovirus identification by electron microscopy in lower respiratory tract infection in a patient with relapsed myelodysplastic syndrome after allogeneic hematopoietic cell transplantation and donor lymphocyte infusion

    Harada N, Nakashima Y, Sakaida M, Mukai D, Makuuchi Y, Kuno M, Takakuwa T, Okamura H, Nishimoto M, Koh H, Ohsawa M, Hino M, Nakamae H

    Transpl Immunol   77   101792   2023.04

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    International / domestic magazine:International journal  

    DOI: 10.1016/j.trim.2023.101792

  • Efficacy of elotuzumab for multiple myeloma in reference to lymphocyte counts and kappa/lambda ratio or B2 microglobulin Reviewed

    Shimazu Y, Kanda J, Kosugi S, Ito T, Kaneko H, Imada K, Shimura Y, Fuchida SI, Fukushima K, Tanaka H, Yoshihara S, Ohta K, Uoshima N, Yagi H, Shibayama H, Yamamura R, Tanaka Y, Uchiyama H, Onda Y, Adachi Y, Hanamoto H, Takahashi R, Matsuda M, Miyoshi T, Takakuwa T, Hino M, Hosen N, Nomura S, Shimazaki C, Matsumura I, Takaori-Kondo A, Kuroda J.

    Sci Rep   13 ( 1 )   5159   2023.03

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    International / domestic magazine:International journal  

    DOI: 10.1038/s41598-023-32426-6

  • Severe short-term adverse events in related bone marrow or peripheral blood stem cell donors Reviewed

    Yanagisawa R, Hirakawa T, Doki N, Ikegame K, Matsuoka KI, Fukuda T, Nakamae H, Ota S, Hiramoto N, Ishikawa J, Ara T, Tanaka M, Koga Y, Kawakita T, Maruyama Y, Kanda Y, Hino M, Atsuta Y, Yabe H, Tsukada N

    Int J Hematol.   117 ( 3 )   421 - 427   2023.03

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    Publishing type:Research paper (scientific journal)   International / domestic magazine:Domestic journal  

    DOI: 10.1007/s12185-022-03489-4

  • Severe short-term adverse events in related bone marrow or peripheral blood stem cell donors(タイトル和訳中)

    Yanagisawa Ryu, Hirakawa Tsuneaki, Doki Noriko, Ikegame Kazuhiro, Matsuoka Ken-ichi, Fukuda Takahiro, Nakamae Hirohisa, Ota Shuichi, Hiramoto Nobuhiro, Ishikawa Jun, Ara Takahide, Tanaka Masatsugu, Koga Yuhki, Kawakita Toshiro, Maruyama Yumiko, Kanda Yoshinobu, Hino Masayuki, Atsuta Yoshiko, Yabe Hiromasa, Tsukada Nobuhiro

    International Journal of Hematology   117 ( 3 )   421 - 427   2023.03( ISSN:0925-5710

  • Ibrutinib Induces a Dramatic Improvement for Idiopathic Refractory Ascites Following Allogeneic Hematopoietic Cell Transplantation Reviewed

    Tazoe K, Nishimoto M, Yamamoto A, Makuuchi Y, Kuno M, Okamura H, Nakashima Y, Tanaka S, Ohsawa M, Hino M, Nakamae H

    Intern Med.   2023.02

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    International / domestic magazine:Domestic journal  

    DOI: 10.2169/internalmedicine.1139-22

  • Salvage Human Leukocyte Antigen-Haploidentical Hematopoietic Cell Transplant With Posttransplant Cyclophosphamide for Graft Failure in a Patient With Chronic Active Epstein-Barr Virus Infection Reviewed

    Nakaya Y, Koh H, Harada N, Okamura H, Misugi T, Suekane T, Tachibana D, Kimura H, Hino M, Nakamae H.

    Exp Clin Transplant   21 ( 2 )   184 - 188   2023.02

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    International / domestic magazine:International journal  

    DOI: 10.6002/ect.2022.0322.

  • Successful treatment of proven coronavirus disease 2019-associated pulmonary aspergillosis with liposomal amphotericin B in a patient with bronchiolitis obliterans syndrome after allogeneic hematopoietic stem cell transplantation Reviewed

    Nakaya Y, Nakashima Y, Harada N, Yamada K, Makuuchi Y, Kuno M, Takakuwa T, Okamura H, Nanno S, Nishimoto M, Koh H, Nakagama Y, Kido Y, Kanno T, Suzuki T, Nakamae H, Kakeya H, Hino M

    J Infect Chemother   29 ( 2 )   223 - 227   2023.02

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    Authorship:Last author   Publishing type:Research paper (scientific journal)   International / domestic magazine:International journal  

    DOI: 10.1016/j.jiac.2022.10.020

  • 同種造血幹細胞移植後の閉塞性細気管支炎症候群患者における確定したCOVID-19関連肺アスペルギルス症のリポソーム型アムホテリシンBを用いた治療成功(Successful treatment of proven coronavirus disease 2019-associated pulmonary aspergillosis with liposomal amphotericin B in a patient with bronchiolitis obliterans syndrome after allogeneic hematopoietic stem cell transplantation)

    Nakaya Yosuke, Nakashima Yasuhiro, Harada Naonori, Yamada Koichi, Makuuchi Yosuke, Kuno Masatomo, Takakuwa Teruhito, Okamura Hiroshi, Nanno Satoru, Nishimoto Mitsutaka, Koh Hideo, Nakagama Yu, Kido Yasutoshi, Kanno Takayuki, Suzuki Tadaki, Nakamae Hirohisa, Kakeya Hiroshi, Hino Masayuki

    Journal of Infection and Chemotherapy   29 ( 2 )   223 - 227   2023.02( ISSN:1341-321X

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    症例は29歳女性で、発熱、息切れ、持続性の乾性咳嗽で当科を受診した。SARS-CoV-2の抗原検査が陽性であり、胸部CTで両側のすりガラス陰影が認められたことから、COVID-19治療のために隔離病棟に入院した。4年前に急性骨髄性白血病の治療で父親からHLA半合致同種造血幹細胞移植を受けていた。白血病は完全寛解に至ったが、造血幹細胞移植から1年半後に閉塞性細気管支炎症候群を発症したため、プレドニゾロンを内服していた。入院後、生存ウイルスの排出を伴わないSARS-CoV-2のRT-PCR陽性の遷延(COVID-19発症後133日)が認められたが、COVID-19をファビピラビル、レムデシビル、デキサメタゾン、エノキサパリンで治療した。しかし、呼吸状態が悪化し、7日目の胸部CTで中心部まで広がるすりガラス陰影と両肺に厚い空洞が多数出現した。気管支肺胞洗浄の培養と肺生検により新型コロナウイルス感染症関連肺アスペルギルス症と診断した。トリアゾール系薬剤(ボリコナゾール、イトラコナゾール、ポサコナゾール)とエキノカンジン系薬剤(カスポファンギン、ミカファンギン)の併用療法には反応しなかったが、合計16週間のリポソーム型アムホテリシンB療法により良好な反応が得られ、213日目に退院した。

  • 造血細胞移植患者手帳の運用状況と改訂の必要性に関する全国アンケート調査 Reviewed

    廣瀬朝生、中前博久、大西 康、黒澤彩子、後藤辰徳、後藤秀樹、土岐典子、橋井佳子、藤井伸治、森島聡子、日野雅之

    日本造血・免疫細胞療法学会雑誌   2023

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    Publishing type:Research paper (scientific journal)   International / domestic magazine:Domestic journal  

  • 末梢血幹細胞採取にアフェレーシスナースが果たしている役割と人的支援のニーズに関するアンケート調査 Reviewed

    難波寛子、柴田玲子、吉田琴恵、池田洋子、國井典子、牧野茂義、武田航、小島稔、福田隆浩、上田恭典、日野雅之

    日本輸血・細胞治療学会雑誌   2023

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    Authorship:Last author   Publishing type:Research paper (scientific journal)   International / domestic magazine:Domestic journal  

  • Impact of cytogenetic abnormalities in symptomatic multiple myeloma; a Japanese real-world analysis from Kansai Myeloma Forum.

    Nakaya A, Shibayama H, Uoshima N, Yamamura R, Yoshioka S, Imada K, Shimura Y, Hotta M, Matsui T, Kosugi S, Hanamoto H, Uchiyama H, Yoshihara S, Fuchida SI, Onda Y, Tanaka Y, Ohta K, Matsuda M, Kanda J, Yoko A, Kiyota M, Kawata E, Takahashi R, Fukushima K, Tanaka H, Yagi H, Takakuwa T, Hosen N, Ito T, Shimazaki C, Takaori-Kondo A, Kuroda J, Matsumura I, Hino M

    Leukemia research reports   20   100395   2023( ISSN:2213-0489

  • Monocyte or white blood cell counts and β2 microglobulin predict the durable efficacy of daratumumab with lenalidomide Reviewed

    Shimazu Y, Kanda J, Kaneko H, Imada K, Yamamura R, Kosugi S, Shimura Y, Ito T, Fuchida SI, Uchiyama H, Fukushima K, Yoshihara S, Hanamoto H, Tanaka H, Uoshima N, Ohta K, Yagi H, Shibayama H, Onda Y, Tanaka Y, Adachi Y, Matsuda M, Iida M, Miyoshi T, Matsui T, Takahashi R, Takakuwa T, Hino M, Hosen N, Nomura S, Shimazaki C, Matsumura I, Takaori-Kondo A, Kuroda J; Kansai Myeloma Forum.

    Ther Adv Hematol   2022.12

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    Publishing type:Research paper (scientific journal)   International / domestic magazine:International journal  

    DOI: 10.1177/20406207221142487

  • Adenovirus disease after hematopoietic cell transplantation: A Japanese transplant registry analysis Reviewed

    Inamoto Y, Takeda W, Hirakawa T, Sakaguchi H, Nakano N, Uchida N, Doki N, Ikegame K, Katayama Y, Sawa M, Kuriyama T, Hiramoto N, Ota S, Ozawa Y, Kataoka K, Kanda Y, Hino M, Kimura T, Atsuta Y, Fukuda T, Nagafuji K.

    Am J Hematol   97 ( 12 )   1568 - 1579   2022.12

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    Publishing type:Research paper (scientific journal)   International / domestic magazine:International journal  

    DOI: 10.1002/ajh.26723

  • Bosutinib in Japanese patients with newly diagnosed chronic-phase chronic myeloid leukemia: final 3-year follow-up results of a phase 2 study(和訳中)

    Ono Takaaki, Hino Masayuki, Matsumura Itaru, Fujisawa Shin, Ishizawa Kenichi, Sakaida Emiko, Sekiguchi Naohiro, Ono Chiho, Aizawa Mana, Tanetsugu Yusuke, Koide Yuichiro, Takahashi Naoto

    International Journal of Hematology   116 ( 6 )   871 - 882   2022.12( ISSN:0925-5710

  • Bosutinib in Japanese patients with newly diagnosed chronic-phase chronic myeloid leukemia: final 3-year follow-up results of a phase 2 study.

    Ono T, Hino M, Matsumura I, Fujisawa S, Ishizawa K, Sakaida E, Sekiguchi N, Ono C, Aizawa M, Tanetsugu Y, Koide Y, Takahashi N

    International journal of hematology   116 ( 6 )   871 - 882   2022.12( ISSN:0925-5710

  • Intramural esophageal hematoma precipitated by acquired factor XI deficiency in a patient with relapsed T cell prolymphocytic leukemia after allogeneic hematopoietic cell transplantation Reviewed

    Harada N, Makuuchi Y, Kuno M, Takakuwa T, Okamura H, Nishimoto M, Nakashima Y, Koh H, Bingo M, Higashimori A, Fujiwara Y, Hino M, Nakamae H.

    Ann Hematol   101 ( 11 )   2567 - 2569   2022.11

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    Publishing type:Research paper (scientific journal)   International / domestic magazine:International journal  

    DOI: 10.1007/s00277-022-04970-0

  • BNT162b2 COVID-19ワクチン接種後に温式自己免疫性溶血性貧血とIgM-M蛋白血症を発症した脾辺縁帯リンパ腫

    曽我部 信広, 久野 雅智, 中釜 悠, 幕内 陽介, 原田 尚憲, 高桑 輝人, 岡村 浩史, 廣瀬 朝生, 西本 光孝, 中嶋 康博, 康 秀男, 中前 美佳, 城戸 康年, 中前 博久, 日野 雅之

    臨床血液   63 ( 10 )   1379 - 1385   2022.10( ISSN:0485-1439

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    新型コロナウイルス(SARS-CoV-2)に対するmRNA COVID-19ワクチン接種後に自己免疫性血球減少を発症することが知られているが,成熟B細胞腫瘍患者のワクチン接種が腫瘍随伴症状へ与える影響を調べた報告はない。症例は71歳男性。数年前に成熟B細胞腫瘍を疑う症状があったが自然軽快し経過観察されていた。BNT162b2 mRNA COVID-19ワクチン2回目接種10日後に温式自己免疫性溶血性貧血を発症した。貧血はステロイドで改善したが,脾腫,IgM-M蛋白血症,腎障害が増悪した。診断・治療目的に脾臓摘出術を施行し,脾辺縁帯リンパ腫と診断され,M蛋白血症,腎障害は改善した。本症例でSARS-CoV-2特異的抗体の獲得は障害されていた。ワクチン接種後の非特異的な免疫賦活が,成熟B細胞腫瘍の腫瘍随伴症状を増悪させる可能性が示唆されたが,病態解明のためにさらなる症例集積が必要である。(著者抄録)

  • Polatuzumab vedotin combined with rituximab-bendamustine immediately before stem cell mobilization in relapsed diffuse large B-cell lymphoma.

    Takakuwa T, Okayama Y, Nakamae H, Kuno M, Makuuchi Y, Harada N, Okamura H, Nishimoto M, Nakashima Y, Koh H, Hino M

    Annals of hematology   101 ( 7 )   1609 - 1610   2022.07( ISSN:0939-5555

  • Immunomodulatory and direct activities of ropeginterferon alfa-2b on cancer cells in mouse models of leukemia.

    Sakatoku K, Nakashima Y, Nagasaki J, Nishimoto M, Hirose A, Nakamae M, Koh H, Hino M, Nakamae H

    Cancer science   113 ( 7 )   2246 - 2257   2022.07( ISSN:1347-9032

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  • 白血病マウスモデルにおけるロペグインターフェロンα-2bの癌細胞に対する免疫調節活性と直接活性(Immunomodulatory and direct activities of ropeginterferon alfa-2b on cancer cells in mouse models of leukemia)

    Sakatoku Kazuki, Nakashima Yasuhiro, Nagasaki Joji, Nishimoto Mitsutaka, Hirose Asao, Nakamae Mika, Koh Hideo, Hino Masayuki, Nakamae Hirohisa

    Cancer Science   113 ( 7 )   2246 - 2257   2022.07( ISSN:1347-9032

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    マウスB細胞白血病細胞株BA-1を用いたマウス白血病モデルに対するモノPEG化αインターフェロンであるロペグインターフェロンα-2b(ropeg)の抗腫瘍効果を検討した。ropeg療法は、白血病マウスでは生存期間を有意に延長し、一部のマウスでは長期寛解をもたらした。従来のインターフェロンα治療では、生存期間が僅かに延長しただけで、全てのマウスが死亡した。腫瘍に対する直接的な効果を確認するために、白血病発症後のインターフェロンα受容体1ノックアウトマウスにropegを投与したところ、マウスの生存期間は僅かに延長したが、全てのマウスが死亡した。In vivoにおけるCD4+またはCD8+T-細胞の枯渇がropegの治療効果を著しく低下させたことから、ropegの宿主養子免疫刺激作用が腫瘍細胞抑制の主要なメカニズムであることが示唆された。長期寛解状態にあるマウスは、腫瘍の再チャレンジ後でも白血病を発症することはなかった。再チャレンジ腫瘍の拒絶反応は、CD4+とCD8+の両方のT細胞を生体内で除去した場合にのみキャンセルされたことから、免疫学的記憶においてそれぞれのT細胞群が独立して機能することが示唆された。以上より、ropegは宿主において優れた抗腫瘍免疫調節機能を発揮した。

  • A phase II study of post-transplant cyclophosphamide combined with tacrolimus for GVHD prophylaxis after HLA-matched related/unrelated allogeneic hematopoietic stem cell transplantation.

    Nakamae H, Nakane T, Okamura H, Koh H, Nakashima Y, Hirose A, Nakamae M, Nishimoto M, Kuno M, Makuuchi Y, Harada N, Takakuwa T, Hino M

    International journal of hematology   115 ( 1 )   77 - 86   2022.06( ISSN:0925-5710

  • Real-world effectiveness and safety analysis of carfilzomib-lenalidomide-dexamethasone and carfilzomib-dexamethasone in relapsed/refractory multiple myeloma: a multicenter retrospective analysis Reviewed

    Onda Y, Kanda J, Kaneko H, Shimura Y, Fuchida SI, Nakaya A, Itou T, Yamamura R, Tanaka H, Shibayama H, Shimazu Y, Uchiyama H, Yoshihara S, Adachi Y, Matsuda M, Hanamoto H, Uoshima N, Kosugi S, Ohta K, Yagi H, Kanakura Y, Matsumura I, Hino M, Nomura S, Shimazaki C, Takaori-Kondo A, Kuroda J; Kansai Myeloma Forum.

    Ther Adv Hematol   2022.06

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    Publishing type:Research paper (scientific journal)   International / domestic magazine:International journal  

    DOI: 10.1177/20406207221104584

  • Phagocytosis of Mature Granulocytes by Bone Marrow Macrophages in an Elderly Man with Adult-Onset Primary Autoimmune Neutropenia.

    Nishimoto M, Nakane T, Koh H, Nakashima Y, Yamamura R, Nakamae H, Hino M, Ohta K

    Hematology reports   14 ( 2 )   165 - 171   2022.05( ISSN:2038-8322

  • Long-term use of foscarnet is associated with an increased incidence of acute kidney injury in hematopoietic stem cell transplant patients: A retrospective observational study.

    Inose R, Takahashi K, Takahashi M, Sugimoto T, Nanno S, Hino M, Nagayama K

    Transplant infectious disease : an official journal of the Transplantation Society   24 ( 2 )   e13804   2022.04( ISSN:1398-2273

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  • Visceral disseminated varicella zoster virus infection following COVID-19 vaccination in an allogeneic stem cell transplant recipient.

    Nishimoto M, Sogabe N, Hino M

    Transplant infectious disease : an official journal of the Transplantation Society   24 ( 2 )   e13810   2022.04( ISSN:1398-2273

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  • Predictive value of clinical examination parameters for cardiovascular adverse events during treatment of chronic myeloid leukemia with tyrosine kinase inhibitors.

    Nakamae M, Nakamae H, Hashimoto M, Koh H, Nakashima Y, Hirose A, Hino M

    International journal of hematology   115 ( 3 )   329 - 335   2022.03( ISSN:0925-5710

  • チロシンキナーゼ阻害薬を用いた慢性骨髄性白血病治療下での心血管有害事象に対し、臨床検査パラメータによる予測能(Predictive value of clinical examination parameters for cardiovascular adverse events during treatment of chronic myeloid leukemia with tyrosine kinase inhibitors)

    Nakamae Mika, Nakamae Hirohisa, Hashimoto Mika, Koh Hideo, Nakashima Yasuhiro, Hirose Asao, Hino Masayuki

    International Journal of Hematology   115 ( 3 )   329 - 335   2022.03( ISSN:0925-5710

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    慢性骨髄性白血病(CML)の治療に用いられる、チロシンキナーゼ阻害薬(TKI)のオフターゲット効果により生じる心血管有害事象(CAE)に対し、最適なモニタリング法について検討した。TKI投与を受けているCML患者74例(男性46例、女性28例、年齢21~91歳)を対象に、足関節上腕血圧比(ABI)、心臓足首血管指数(CAVI)、頸動脈エコー、心電図等の様々な心血管パラメータを包括的に評価することで、CAEのモニタリングと予測を試みた。その結果、C統計量により、ABIとCAVIを追加することで、確立されたリスク因子モデルの予測能が有意に上昇し、高血圧と喫煙歴および脂質異常症のモデル1では0.680と0.817、高血圧と脂質異常症および糖尿病のモデル2では0.685と.0.830、年齢と高血圧および脂質異常症と糖尿病のモデル3では0.737と0.818であることが確認された。だが、単独の心血管パラメータを用いて確立したリスク因子モデルの予測能に関しては、改善することは出来なかった。以上より、確立されたリスク因子モデルにABIとCAVIを併用した評価を追加することにより、CAE予測が改善され、TKI治療下にあるCML患者の臨床管理に有用な指標となり得ることが示唆された。

  • Selective targeting of multiple myeloma cells with a monoclonal antibody recognizing the ubiquitous protein CD98 heavy chain.

    Hasegawa K, Ikeda S, Yaga M, Watanabe K, Urakawa R, Iehara A, Iwai M, Hashiguchi S, Morimoto S, Fujiki F, Nakajima H, Nakata J, Nishida S, Tsuboi A, Oka Y, Yoshihara S, Manabe M, Ichihara H, Mugitani A, Aoyama Y, Nakao T, Hirose A, Hino M, Ueda S, Takenaka K, Masuko T, Akashi K, Maruno T, Uchiyama S, Takamatsu S, Wada N, Morii E, Nagamori S, Motooka D, Kanai Y, Oji Y, Nakagawa T, Kijima N, Kishima H, Ikeda A, Ogino T, Shintani Y, Kubo T, Mihara E, Yusa K, Sugiyama H, Takagi J, Miyoshi E, Kumanogoh A, Hosen N

    Science translational medicine   14 ( 632 )   eaax7706   2022.02( ISSN:1946-6234

  • PD-1 blockade therapy promotes infiltration of tumor-attacking exhausted T cell clonotypes.

    Nagasaki J, Inozume T, Sax N, Ariyasu R, Ishikawa M, Yamashita K, Kawazu M, Ueno T, Irie T, Tanji E, Morinaga T, Honobe A, Ohnuma T, Yoshino M, Iwata T, Kawase K, Sasaki K, Hanazawa T, Kochin V, Kawamura T, Matsue H, Hino M, Mano H, Suzuki Y, Nishikawa H, Togashi Y

    Cell reports   38 ( 5 )   110331   2022.02

  • Use of Eltrombopag for the First Trimester Pregnancy Complicated with Refractory Idiopathic Thrombocytopenic Purpura: A Case Report and Literature Review.

    Shibata S, Misugi T, Nakane T, Hino M, Tachibana D

    Cureus   14 ( 2 )   e22505   2022.02

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  • Delayed immune-related neutropenia with hepatitis by pembrolizumab.

    Nakako S, Nakashima Y, Okamura H, Tani Y, Ueda T, Makuuchi Y, Kuno M, Takakuwa T, Nishimoto M, Koh H, Nakamae H, Hino M

    Immunotherapy   14 ( 2 )   101 - 105   2022.02( ISSN:1750-743X

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  • 急速にMGUSから多発性骨髄腫に進行し多臓器不全を呈した原発性アミロイドーシス

    田添 久実代, 高桑 輝人, 幕内 陽介, 久野 雅智, 原田 尚憲, 岡村 浩史, 西本 光孝, 康 秀男, 中嶋 康博, 中前 博久, 日野 雅之

    臨床血液   63 ( 1 )   31 - 36   2022.01( ISSN:0485-1439

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    意義不明の単クローン性免疫グロブリン血症(MGUS)は通常無症候性であり無治療経過観察が標準治療であるが,年に1.5%の頻度で骨髄腫関連腫瘍に進行する。病勢進行の判断が一般的な検査では困難な場合もあり,今回長期間無症状で,突然の腎機能障害を契機に多発性骨髄腫への病勢進行が判明したMGUSの症例を報告する。症例は66歳女性。IgA-κ型のMGUSの診断に至ってから8年後,急激な腎機能障害を認めて持続的血液濾過透析を要した。精査の結果IgA-κ型の多発性骨髄腫の診断に至り,化学療法が奏効せず,敗血症を合併して第19病日に死亡した。その後,病理解剖で全身アミロイドーシスおよび黄色ブドウ球菌による多発膿瘍の合併が判明した。MGUSの病勢進行のリスクとして遊離軽鎖κ/λ比の異常やM蛋白がIgG以外であることが報告されている。これらのリスクを有する症例では早期診断のために常に病勢進行の可能性を念頭において注意深く観察を行うことが重要である。(著者抄録)

  • High-Dose Chemotherapy With Autologous Stem Cell Transplantation in a Case of Refractory Peripheral T Cell Lymphoma With Tracheoesophageal Fistula: A Case Report.

    Hayashi T, Nakashima Y, Nishimoto M, Nanno S, Naka R, Gyobu K, Lee S, Okamoto S, Hino M, Nakamae H

    Transplantation proceedings   54 ( 1 )   189 - 192   2022.01( ISSN:0041-1345

  • Effect of Donor NKG2D Polymorphism on Relapse after Haploidentical Transplantation with Post-Transplantation Cyclophosphamide.

    Ido K, Koh H, Hirose A, Seto T, Makuuchi Y, Kuno M, Takakuwa T, Okamura H, Nanno S, Nakamae M, Nishimoto M, Nakashima Y, Hino M, Nakamae H

    Transplantation and cellular therapy   28 ( 1 )   20.e1 - 20.e10   2022.01( ISSN:2666-6375

  • Correction to: A phase II study of post‑transplant cyclophosphamide combined with tacrolimus for GVHD prophylaxis after HLA‑matched related/unrelated allogeneic hematopoietic stem cell transplantation.

    Nakamae H, Nakane T, Okamura H, Koh H, Nakashima Y, Hirose A, Nakamae M, Nishimoto M, Kuno M, Makuuchi Y, Harada N, Takakuwa T, Hino M

    International journal of hematology   115 ( 1 )   146   2022.01( ISSN:0925-5710

  • HLA一致血縁/非血縁同種造血幹細胞移植後のGVHD予防を目的とした移植後シクロホスファミドとタクロリムスの併用療法に関する第II相臨床試験(A phase II study of post-transplant cyclophosphamide combined with tacrolimus for GVHD prophylaxis after HLA-matched related/unrelated allogeneic hematopoietic stem cell transplantation)

    Nakamae Hirohisa, Nakane Takahiko, Okamura Hiroshi, Koh Hideo, Nakashima Yasuhiro, Hirose Asao, Nakamae Mika, Nishimoto Mitsutaka, Kuno Masatomo, Makuuchi Yosuke, Harada Naonori, Takakuwa Teruhito, Hino Masayuki

    International Journal of Hematology   115 ( 1 )   77 - 86   2022.01( ISSN:0925-5710

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    HLA一致血縁/非血縁同種造血幹細胞移植後の移植片対宿主病(GVHD)予防のためのシクロホスファミド(PTCy)とカルシニューリン阻害剤であるタクロリムス(TAC)の併用の安全性と有効性を前向きに検討した。血液悪性腫瘍患者39例は、HLA一致血縁ドナー(MRD)(年齢30~65歳)またはHLA一致非血縁ドナー(MUD)(年齢29~66歳)から同種造血幹細胞移植を受けた。移植後100日目におけるグレードII~IVおよびIII~IVの急性GVHDの累積発生率は、MRD群でそれぞれ18%および5.9%、MUD群でそれぞれ18%および9.1%であった。1年後の中等度または重度の慢性GVHDの累積発生率は、MRD群、MUD群でそれぞれ12%、9.1%であった。MRD群とMUD群の1年全生存率はそれぞれ88%と64%で、1年GVHDがない無再発生存率はそれぞれ59%と50%であった。以上より、HLA一致造血幹細胞移植後に、より強度の低い2剤併用(PT/CyとTAC)によるGVHD予防が実行可能である可能性が示唆された。

  • A Prospective Study of an HLA-Haploidentical Peripheral Blood Stem Cell Transplantation Regimen Based on Modification of the Dose of Posttransplant Cyclophosphamide for Poor Prognosis or Refractory Hematological Malignancies Reviewed

    Nakamae H, Okamura H, Hirose A, Koh H, Nakashima Y, Nakamae M, Nishimoto M, Makuuchi Y, Kuno M, Harada N, Takakuwa T, Hino M

    Cell Transplant.   2022

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    Authorship:Last author   Publishing type:Research paper (scientific journal)   International / domestic magazine:International journal  

    DOI: 10.1177/09636897221112098

  • WEBを用いた採取可能日情報の事前入力によるコーディネート期間短縮の試み Reviewed

    日野雅之、梅本由香里、幕内陽介、岡村浩史、康 秀男、萩山恵子、折原勝己、中尾隆文、岡田昌也、魚嶋伸彦、伊藤 満、藥師神公和、西川彰則、石川 淳、水野石一、石川隆之、福田隆浩

    日本造血・免疫細胞療法学会雑誌   11 ( 2 )   114 - 121   2022

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    Authorship:Lead author   Publishing type:Research paper (scientific journal)   International / domestic magazine:Domestic journal  

  • Warm autoimmune hemolytic anemia and IgM-monoclonal gammopathy following BNT162b2 COVID-19 vaccine in a patient with splenic marginal zone lymphoma

    SOGABE Nobuhiro, KUNO Masatomo, NAKAGAMA Yu, MAKUUCHI Yosuke, HARADA Naonori, TAKAKUWA Teruhito, OKAMURA Hiroshi, HIROSE Asao, NISHIMOTO Mitsutaka, NAKASHIMA Yasuhiro, KOH Hideo, NAKAMAE Mika, KIDO Yasutoshi, NAKAMAE Hirohisa, HINO Masayuki

    Rinsho Ketsueki   63 ( 10 )   1379 - 1385   2022( ISSN:0485-1439

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    <p>There is currently no evidence that a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mRNA vaccine might be associated with the development of autoimmune hemolytic anemia or disease progression in patients with mature B-cell neoplasm. Our patient was a 71-year-old man with indolent mature B-cell neoplasm who had been monitored for many years without treatment. After receiving the second dose of the BNT162b2 mRNA COVID-19 vaccine, he developed severe warm autoimmune hemolytic anemia. Although steroid therapy improved his anemia, he continued to develop IgM-monoclonal gammopathy, renal insufficiency, and splenomegaly. He was diagnosed with splenic marginal zone lymphoma after undergoing splenectomy. The splenectomy improved the patient’s symptoms. We assessed his SARS-CoV-2 specific antibody response, but the patient’s serologic response to the vaccine was impaired. In patients with mature B-cell neoplasm, a non-specific immune response after vaccination might be associated with paraneoplastic syndromes.</p>

    DOI: 10.11406/rinketsu.63.1379

    PubMed

  • AL amyloidosis presenting with fluminant multiorgan failure accompanied by rapid progression from MGUS to multiple myeloma

    TAZOE Kumiyo, TAKAKUWA Teruhito, MAKUUCHI Yosuke, KUNO Masatomo, HARADA Naonori, OKAMURA Hiroshi, NISHIMOTO Mitsutaka, KOH Hideo, NAKASHIMA Yasuhiro, NAKAMAE Hirohisa, HINO Masayuki

    Rinsho Ketsueki   63 ( 1 )   31 - 36   2022( ISSN:0485-1439

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    <p>Monoclonal gammopathy of undermined significance (MGUS) is usually asymptomatic, and untreated follow-up is the standard treatment. However, MGUS progresses to multiple myeloma or related malignancy at a frequency of 1.5% per year. It is sometimes difficult to diagnose the progression of the disease via usual examinations. We herein report a case wherein rapid renal dysfunction led to a diagnosis of disease progression to multiple myeloma in a patient with MGUS that was asymptomatic for a long time. A 66-year-old woman developed rapid renal dysfunction requiring continuous hemodiafiltration 8 years after the diagnosis of IgA-κ type MGUS. A complete examination led to the diagnosis of IgA-κ type multiple myeloma. Chemotherapy was not effective, and she died due to sepsis on the 19th day of admission. A pathological autopsy revealed systemic amyloidosis and multiple abscesses positive for <i>Staphylococcus aureus</i>. An abnormal free light chain κ/λ ratio and M protein other than IgG are reportedly risk factors of disease progression of MGUS. In cases with these risk factors, it is important to always keep in mind the possibility of disease progression and to monitor the patient carefully for an early diagnosis.</p>

    DOI: 10.11406/rinketsu.63.31

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  • Discrepant Antigen-specific Antibody Responses Causing SARS-CoV-2 Persistence in a Patient Receiving B-cell-targeted Therapy with Rituximab(和訳中)

    Takakuwa Teruhito, Nakagama Yu, Yasugi Mayo, Maeda Toshiki, Matsuo Kenji, Kiritoshi Ayako, Deguchi Ryo, Hagawa Naohiro, Shibata Wataru, Oshima Kazuhiro, Yamamoto Katsumi, Uchida Kenichiro, Noda Tomohiro, Yamada Koichi, Nishimura Tetsuro, Yamamoto Hiromasa, Kido Yasutoshi, Hino Masayuki, Kakeya Hiroshi, Mizobata Yasumitsu

    Internal Medicine   60 ( 23 )   3827 - 3831   2021.12( ISSN:0918-2918

  • 特集  貧血と諸疾患の機序を探る 特集にあたって

    日野 雅之

    Pharma Medica   39 ( 11 )   7 - 7   2021.11( ISSN:02895803

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  • Isoniazid-induced Immune Thrombocytopenia

    Kuwabara Gaku, Tazoe Kumiyo, Imoto Waki, Yamairi Kazushi, Shibata Wataru, Oshima Kazuhiro, Yamada Koichi, Takagi Yasuhiro, Shiraishi Satoshi, Hino Masayuki, Kawaguchi Tomoya, Kakeya Hiroshi

    Internal Medicine   60 ( 22 )   3639 - 3643   2021.11( ISSN:0918-2918

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    <p>Drug-induced thrombocytopenia occurs through immune-mediated platelet destruction, and its management is challenging during tuberculosis treatment. Although rifampicin is the most common drug causing thrombocytopenia, isoniazid can also cause thrombocytopenia. We herein report a 75-year-old man who developed thrombocytopenia during tuberculosis treatment. Platelet-associated immunoglobulin G and a drug-induced lymphocyte stimulation test for isoniazid were positive; no other causes of thrombocytopenia were identified. The patient was diagnosed with isoniazid-induced immune thrombocytopenia, and the platelet count normalized after isoniazid discontinuation. We describe the immunological mechanism of thrombocytosis due to isoniazid, an uncommon cause of thrombocytopenia that physicians should be aware exists. </p>

    DOI: 10.2169/internalmedicine.6520-20

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  • Increasing numbers of CD19 + CD24<sup>high</sup>CD38<sup>high</sup> regulatory B cells and pre-germinal center B cells reflect activated autoimmunity and predict future treatment response in patients with untreated immune thrombocytopenia.

    Hayashi T, Nakamae H, Takeda S, Nakashima Y, Koh H, Nishimoto M, Okamura H, Nanno S, Makuuchi Y, Kuno M, Nakamae M, Hirose A, Hino M

    International journal of hematology   114 ( 5 )   580 - 590   2021.11( ISSN:0925-5710

  • イソニアジド誘発性免疫性血小板減少症(Isoniazid-induced Immune Thrombocytopenia)

    Kuwabara Gaku, Tazoe Kumiyo, Imoto Waki, Yamairi Kazushi, Shibata Wataru, Oshima Kazuhiro, Yamada Koichi, Takagi Yasuhiro, Shiraishi Satoshi, Hino Masayuki, Kawaguchi Tomoya, Kakeya Hiroshi

    Internal Medicine   60 ( 22 )   3639 - 3643   2021.11( ISSN:0918-2918

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    症例は75歳男性で、結核および結核性脊椎炎と診断され、他院でリファンピシン(RFP)、イソニアジド(INH)、エタンブトール(EB)、ピラジナミドによる治療を開始した。1ヵ月後、肝毒性が出現し、薬剤を中止した。薬剤中止後11日目、血小板数が減少し、その後に増加した。肝機能が改善後、INHとRFPで脱感作したが、肝毒性が再発した。RFPを中止し、INHとEBを継続した。治療開始後3ヵ月目(RFP中止後10日目)、治療継続が困難であったため、搬送されてきた。血小板数が少なかったため、入院1日目と2日目に血小板輸血を行った。貧血に対し、入院1日目に赤血球輸血も行った。検査所見から、結核による二次性貧血と診断した。血小板数の減少はINH投与と関連していたため、入院3日目にINHを中止し、レボフロキサシンとストレプトマイシンを追加した。血小板関連免疫グロブリンGが陽性で、薬剤誘発性リンパ球刺激試験ではINHが陽性、RFPが陰性であった。血小板減少の他の原因は特定されなかったため、INH誘発性免疫性血小板減少症と診断した。INHを中止後、血小板数は正常化した。

  • 未治療の免疫性血小板減少症患者におけるCD19+ CD24high CD38high制御性B細胞およびプレ胚中心B細胞の増加は、活性化した自己免疫を反映し、将来の治療反応を予測する(Increasing numbers of CD19+CD24high CD38high regulatory B cells and pre-germinal center B cells reflect activated autoimmunity and predict future treatment response in patients with untreated immune thrombocytopenia)

    Hayashi Tetsuya, Nakamae Hirohisa, Takeda Shinichi, Nakashima Yasuhiro, Koh Hideo, Nishimoto Mitsutaka, Okamura Hiroshi, Nanno Satoru, Makuuchi Yosuke, Kuno Masatomo, Nakamae Mika, Hirose Asao, Hino Masayuki

    International Journal of Hematology   114 ( 5 )   580 - 590   2021.11( ISSN:0925-5710

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    免疫性血小板減少症(ITP)の病態をさらに解明するため、未治療ITP患者の末梢血中のリンパ球サブセットとサイトカイン血清レベルや血小板関連IgG(PAIgG)抗体価との関連を検討した。ITP患者では、健常対照者と比較して、CD19+ CD24high CD38high制御性B細胞、プレ胚中心B細胞、およびプラズマブラスト様B細胞の割合が有意に高かった。制御性B細胞およびプレ胚中心B細胞の絶対数は、二次治療が必要なITP患者で有意に高かった。さらに、血清中の腫瘍壊死因子ファミリーに属するB細胞活性化因子腫瘍壊死因子(BAFF)レベルおよび血小板関連免疫グロブリンG抗体価は、制御性B細胞、プレ胚中心B細胞、および自己応答性B細胞の細胞数と正の相関があった。血清インターフェロンα(IFNα)レベルは、自己応答性B細胞数の多いITP患者4例で上昇していた。以上より、制御性B細胞とプレ胚中心B細胞の増加は、BAFFやIFNαによって活性化される自己免疫を反映している可能性があり、未治療ITP患者におけるB細胞サブセットの評価は治療効果を予測する可能性が示唆された。

  • Significance of maintenance therapy after HDT/ASCT in symptomatic multiple myeloma: A multicenter retrospective analysis in Kansai Myeloma Forum Reviewed

    EJHaem   2 ( 4 )   765 - 773   2021.10

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    Publishing type:Research paper (scientific journal)   International / domestic magazine:International journal  

    DOI: 10.1002/jha2.284

  • Tiny transformed diffuse large B cell lymphoma localized to the left conjunctiva.

    Harada N, Tagami M, Koh H, Ohsawa M, Hino M, Nakamae H

    International journal of hematology   114 ( 4 )   413 - 414   2021.10( ISSN:0925-5710

  • Very elderly patients with myeloma: a multicenter retrospective analysis from Kansai Myeloma Forum(和訳中)

    岡山 裕介, 高桑 輝人, 志村 勇司, 金子 仁臣, 今田 和典, 小杉 智, 伊藤 量基, 淵田 真一, 田中 宏和, 魚嶋 伸彦, 吉原 哲, 諫田 淳也, 柴山 浩彦, 福島 健太郎, 太田 健介, 八木 秀男, 野村 昌作, 島崎 千尋, 松村 到, 高折 晃史, 保仙 直毅, 日野 雅之, 黒田 純也

    日本血液学会学術集会   83回   OS1 - 1   2021.09

  • Novel web application predicting patient-specific prognosis in MM from KMF using machine learning(和訳中)

    高桑 輝人, 岡村 浩史, 島津 裕, 金子 仁臣, 今田 和典, 伊藤 量基, 山村 亮介, 太田 健介, 小杉 智, 田中 宏和, 淵田 真一, 志村 勇司, 諫田 淳也, 魚嶋 伸彦, 柴山 浩彦, 吉原 哲, 八木 秀男, 日野 雅之, 金倉 譲, 黒田 純也, 高折 晃史, 島崎 千尋, 松村 到, 野村 昌作

    日本血液学会学術集会   83回   OS1 - 2   2021.09

  • Efficacy of elotuzumab plus lenalidomide and dexamethasone for MM: A retrospective analysis from KMF(和訳中)

    淵田 真一, 伊藤 量基, 小杉 智, 太田 健介, 内山 人二, 島津 裕, 恩田 佳幸, 金子 仁臣, 足立 陽子, 高桑 輝人, 諫田 淳也, 魚嶋 伸彦, 柴山 浩彦, 福島 健太郎, 田中 宏和, 志村 勇司, 今田 和典, 八木 秀男, 吉原 哲, 日野 雅之, 保仙 直毅, 高折 晃史, 松村 到, 野村 昌作, 島崎 千尋, 黒田 純也

    日本血液学会学術集会   83回   OS1 - 4   2021.09

  • Kinetics of IgG subclasses and their effects on the incidence of infection after allogeneic hematopoietic stem cell transplantation.

    Koh S, Koh H, Nanno S, Okamura H, Nakashima Y, Nakamae M, Hirose A, Hino M, Nakamae H

    Transplant immunology   67   101413   2021.08( ISSN:0966-3274

  • Acute fibrinous and organizing pneumonia following hemophagocytic syndrome in two adult patients with hematological malignancies

    Nanno Satoru, Koh Hideo, Okamura Hiroshi, Nishimoto Mitsutaka, Nakashima Yasuhiro, Ohsawa Masahiko, Hino Masayuki, Nakamae Hirohisa

    Journal of Clinical and Experimental Hematopathology   61 ( 2 )   93 - 96   2021.06( ISSN:1346-4280

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    <p>Acute fibrinous and organizing pneumonia (AFOP) is a rare acute lung injury featuring pathological intra-alveolar fibrin balls and organizing pneumonia without hyaline membranes or eosinophils. AFOP forms acute and subacute patterns; the former often has a poor prognosis, whereas the latter has better survival. Secondary hemophagocytic syndrome (HPS) is a cytokine-related and potentially lethal disorder induced by various diseases, and pulmonary involvement in HPS is not rare. However, to our knowledge, no report has addressed the association between secondary HPS and AFOP development. We report two cases of subacute AFOP following HPS in hematological malignancies.</p>

    DOI: 10.3960/jslrt.20042

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  • リンパ管造影により乳び胸水が著明に改善したびまん性大細胞型B細胞リンパ腫

    森口 慎, 高桑 輝人, 影山 健, 岡村 浩史, 南野 智, 西本 光孝, 中嶋 康博, 康 秀男, 中根 孝彦, 山本 晃, 中前 博久, 日野 雅之

    臨床血液   62 ( 6 )   554 - 559   2021.06( ISSN:0485-1439

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    乳び胸水はびまん性大細胞型B細胞リンパ腫(DLBCL)の症例にまれに認められる臨床徴候であるが,管理に難渋する場合が多く予後不良である。症例は59歳の女性で,DLBCLの診断時に右胸水貯留を認めた。化学療法に反応してリンパ腫病変は縮小したが胸水の増悪を認めた。胸水穿刺にて乳び胸水と診断し,絶食・中心静脈栄養管理を行うも効果は不良であった。乳び胸水の原因精査のため超音波ガイド下で鼠径リンパ節穿刺によるリンパ管造影検査を行った。乳びの漏出部位は特定できなかったが,検査翌日に胸水の著明な改善を認め,2ヵ月で胸水は完全に消失した。リンパ管造影検査は低侵襲で合併症が少ない検査であり,乳びの漏出部位の特定だけではなく乳び胸水の改善・消失にも寄与する可能性があるため,化学療法や栄養管理に反応しない難治性乳び胸水に対し検討すべき検査と考えられる。(著者抄録)

  • Successful management of therapy-related chronic myelomonocytic leukemia with cytarabine, aclarubicin, and azacitidine following tegafur/gimeracil/oteracil.

    Nakako S, Takakuwa T, Ichimura H, Okamura H, Nanno S, Nishimoto M, Nakashima Y, Koh H, Hino M, Nakamae H

    Clinical case reports   9 ( 6 )   e04298   2021.06

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  • 成人血液悪性腫瘍患者2例に発症した血球貪食症候群に続く急性線維素性器質化肺炎(Acute fibrinous and organizing pneumonia following hemophagocytic syndrome in two adult patients with hematological malignancies)

    Nanno Satoru, Koh Hideo, Okamura Hiroshi, Nishimoto Mitsutaka, Nakashima Yasuhiro, Ohsawa Masahiko, Hino Masayuki, Nakamae Hirohisa

    Journal of Clinical and Experimental Hematopathology   61 ( 2 )   93 - 96   2021.06( ISSN:1346-4280

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    症例1は63歳男性で、トリソミー8に起因する骨髄異形成症候群であった。その1年半後、輸血依存症となり、低用量プレドニゾロン(PSL)とメテノロンの投与を開始した。その4ヵ月後に汎血球減少、脾腫、高フェリチン血症を呈した。骨髄は低形成で、芽球が22.4%、血球が5.2%であった。また、染色体分析により、5q欠失とトリソミー8を含む複雑な核型が認められた。血球貪食症候群(HPS)と診断した。さらに、右中葉への浸潤と両肺への多発性微小結節が確認された。アムホテリシンBリポソーム製剤(LAMB)とメロペネムの投与では症状は改善しなかった。経気管支肺生検により、急性線維素性器質化肺炎(AFOP)と診断した。メチルプレドニゾロンのパルス療法を行い、その後PSLの維持療法を行った。浸潤性陰影はすぐに消失したが、微小結節は大きくなっていった。その後、ボリコナゾール投与により、病変は徐々に小さくなり消失した。症例2は38歳女性で、縦隔原発B細胞リンパ腫であった。リンパ腫に対する各種薬物療法と放射線照射により、初回の完全奏効が得られた。その1ヵ月後に再発し、2回目のサルベージ化学療法の1クール目で部分奏効が達成された。しかし、発熱性好中球減少症を発症し、左肺にすりガラス様陰影(GGO)を伴う浸潤影が認められた。イミペネム+シラスタチンとカスポファンギンをタゾバクタム+ピペラシリンとLAMBに変更した。発熱を伴う重度の汎血球減少が残ったため、骨髄穿刺を行った結果、血球貪食細胞を含む著しい骨髄低形成が認められた。染色体の核型は正常であった。HPSと診断した。その後、GGOを伴う浸潤影が拡大し、左肺に新たなGGOが発生した。経気管支生検により、AFOPと診断した。PSL投与により、浸潤影は徐々に消失した。

  • Risk Factor and Long-Term Outcome Analyses for Acute Limbic Encephalitis and Calcineurin Inhibitor-Induced Encephalopathy in Adults following Allogeneic Hematopoietic Cell Transplantation.

    Tanizawa N, Koh H, Okamura H, Yamamoto K, Makuuchi Y, Kuno M, Takakuwa T, Koh S, Nanno S, Nishimoto M, Hirose A, Nakamae M, Nakashima Y, Nakane T, Hino M, Nakamae H

    Transplantation and cellular therapy   27 ( 5 )   437.e1 - 437.e9   2021.05( ISSN:2666-6375

  • Recurrence of Acute Lymphoblastic Leukemia with Bone Marrow Necrosis: A Case Report and Review of the Literature on the MRI Features of Bone Marrow Necrosis. Reviewed

    Harada N, Nishimoto M, Ikemoto A, Okamura H, Koh S, Nanno S, Nakashima Y, Koh H, Nakane T, Kuwae Y, Ohsawa M, Hino M, Nakamae H

    一般社団法人 日本内科学会 Internal medicine (Tokyo, Japan)   60 ( 7 )   1083 - 1088   2021.04( ISSN:0918-2918

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    <p>Bone marrow necrosis (BMN) is a rare but important complication of hematological malignancies. We report the case of a 52-year-old male patient with a recurrence of acute lymphoblastic leukemia (ALL) accompanied by BMN. After re-induction therapy, bone marrow aspiration (BMA) and biopsy from the iliac bone showed necrotic cells and eosinophilic debris, respectively. Magnetic resonance imaging (MRI) showed heterogeneous signals in the bilateral iliac bone, possibly reflecting various stages of BMN. BMA from the sternum eventually revealed the recurrence of ALL after a few weeks. Comprehensive assessments, including MRI and repeated bone marrow tests, are required when evaluating the underlying hematological malignancies of patients with BMN. </p>

    DOI: 10.2169/internalmedicine.5815-20

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  • Outcomes of ixazomib/lenalidomide/dexamethasone for multiple myeloma: A multicenter retrospective analysis Reviewed

    Takakuwa Teruhito, Yamamura Ryosuke, Ohta Kensuke, Kaneko Hitomi, Imada Kazunori, Nakaya Aya, Fuchida Shin-ichi, Shibayama Hirohiko, Matsuda Mitsuhiro, Shimazu Yutaka, Adachi Yoko, Kosugi Satoru, Uchiyama Hitoji, Tanaka Hirokazu, Hanamoto Hitoshi, Shimura Yuji, Kanda Junya, Onda Yoshiyuki, Uoshima Nobuhiko, Yagi Hideo, Yoshihara Satoshi, Hino Masayuki, Shimazaki Chihiro, Takaori-Kondo Akifumi, Kuroda Junya, Matsumura Itaru, Kanakura Yuzuru, Nomura Shosaku

    EUROPEAN JOURNAL OF HAEMATOLOGY   106 ( 4 )   555 - 562   2021.04( ISSN:0902-4441

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/ejh.13586

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  • 骨髄壊死を伴う急性リンパ性白血病の再発 1症例報告と骨髄壊死のMRI所見についての文献レビュー(Recurrence of Acute Lymphoblastic Leukemia with Bone Marrow Necrosis: A Case Report and Review of the Literature on the MRI Features of Bone Marrow Necrosis)

    Harada Naonori, Nishimoto Mitsutaka, Ikemoto Aya, Okamura Hiroshi, Koh Shiro, Nanno Satoru, Nakashima Yasuhiro, Koh Hideo, Nakane Takahiko, Kuwae Yuko, Ohsawa Masahiko, Hino Masayuki, Nakamae Hirohisa

    Internal Medicine   60 ( 7 )   1083 - 1088   2021.04( ISSN:0918-2918

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    症例は52歳男性で、フィラデルフィア染色体陽性急性リンパ性白血病(ALL)に対して臍帯血移植を行った。1年後、重度骨痛を伴うALL再発と診断され、再導入療法のために入院した。再導入療法前の骨髄生検では、多数の芽細胞が認められた。入院時には高熱を認め、迅速診断検査でインフルエンザAが陽性であったため、MEC療法(ミトキサントロン、エトポシド、中間用量シタラビン)と静注ペラミビルによる治療を行った。高熱は一時的に改善したが、MEC療法の16日目に再発した。この時点でAspergillus fumigatusが検出されたため、静注ボリコナゾールを開始した。右腸骨からの骨髄穿刺では壊死細胞、骨髄生検では好酸球デブリが認められた。高熱が改善しなかったため、MEC療法の35日目にボリコナゾールをリポソーマルアンホテリシンBに変更した。MEC療法の45日目、腰痛と下肢痛が徐々に悪化した。MRIでは両側腸骨に不均一シグナルが認められ、様々なステージの骨髄壊死を反映していると考えられた。MEC療法の50日目、骨痛が著明に悪化し、51日目に胸骨から行った骨髄穿刺でALL再発が判明した。

  • Plateau is a prognostic factor of lenalidomide therapy for previously treated multiple myeloma. Reviewed

    Takakuwa T, Ohta K, Nakatani E, Ito T, Kaneko H, Fuchida SI, Shimura Y, Yagi H, Shibayama H, Kanda J, Uchiyama H, Kosugi S, Tanaka H, Kawata E, Uoshima N, Ishikawa J, Shibano M, Karasuno T, Shindo M, Shimizu Y, Imada K, Kanakura Y, Kuroda J, Hino M, Nomura S, Takaori-Kondo A, Shimazaki C, Matsumura I

    Hematological oncology   2021.03( ISSN:0278-0232

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/hon.2863

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  • High-grade B-cell lymphoma developed during the treatment of chronic myeloid leukemia with bosutinib Reviewed

    Takakuwa Teruhito, Sakai Ryota, Koh Shiro, Okamura Hiroshi, Nanno Satoru, Nakashima Yasuhiro, Nakane Takahiko, Koh Hideo, Hino Masayuki, Nakamae Hirohisa

    CLINICAL CASE REPORTS   9 ( 3 )   1344 - 1349   2021.03( ISSN:2050-0904

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/ccr3.3770

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  • Pretransplant plasma brain natriuretic peptide and N-terminal probrain natriuretic peptide are more useful prognostic markers of overall survival after allogeneic hematopoietic cell transplantation than echocardiography Reviewed

    Harada Naonori, Okamura Hiroshi, Nakane Takahiko, Koh Shiro, Nanno Satoru, Nishimoto Mitsutaka, Hirose Asao, Nakamae Mika, Nakashima Yasuhiro, Koh Hideo, Hino Masayuki, Nakamae Hirohisa

    BONE MARROW TRANSPLANTATION   2021.02( ISSN:0268-3369

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41409-021-01224-x

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  • Association of serum autotaxin levels with liver fibrosis in patients pretreatment and posttreatment with chronic hepatitis C Reviewed

    Takemura Kazuya, Takizawa Etsuko, Tamori Akihiro, Nakamae Mika, Kubota Hiroshi, Uchida-Kobayashi Sawako, Enomoto Masaru, Kawada Norifumi, Hino Masayuki

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   36 ( 1 )   217 - 224   2021.01( ISSN:0815-9319

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    DOI: 10.1111/jgh.15114

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  • Severe cryoglobulinemia with cerebral infarction successfully treated with steroid and rituximab: A case report Reviewed

    Yagi Naoko, Yoshimura Takuro, Nakamae Hirohisa, Hayashi Daisuke, Tanaka Yasuyuki, Ichikawa Yoshitaka, Hino Masayuki

    CLINICAL CASE REPORTS   9 ( 1 )   543 - 546   2021.01( ISSN:2050-0904

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    DOI: 10.1002/ccr3.3578

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  • Isatuximab plus Pomalidomide and Dexamethasone in a Patient with Dialysis-Dependent Multiple Myeloma.

    Takakuwa T, Ohta K, Sogabe N, Nishimoto M, Kuno M, Makuuchi Y, Okamura H, Nakashima Y, Koh H, Nakamae H, Hino M

    Chemotherapy   66 ( 5-6 )   192 - 195   2021( ISSN:0009-3157

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  • Early Elevation of Complement Factor Ba Is a Predictive Biomarker for Transplant-Associated Thrombotic Microangiopathy.

    Okamura H, Nakamae H, Shindo T, Ohtani K, Hidaka Y, Ohtsuka Y, Makuuchi Y, Kuno M, Takakuwa T, Harada N, Nishimoto M, Nakashima Y, Koh H, Hirose A, Nakamae M, Wakamiya N, Hino M, Inoue N

    Frontiers in immunology   12   695037   2021

  • Discrepant Antigen-specific Antibody Responses Causing SARS-CoV-2 Persistence in a Patient Receiving B-cell-targeted Therapy with Rituximab

    Takakuwa Teruhito, Nakagama Yu, Yasugi Mayo, Maeda Toshiki, Matsuo Kenji, Kiritoshi Ayako, Deguchi Ryo, Hagawa Naohiro, Shibata Wataru, Oshima Kazuhiro, Yamamoto Katsumi, Uchida Kenichiro, Noda Tomohiro, Yamada Koichi, Nishimura Tetsuro, Yamamoto Hiromasa, Kido Yasutoshi, Hino Masayuki, Kakeya Hiroshi, Mizobata Yasumitsu

    Internal Medicine   60 ( 23 )   3827 - 3831   2021( ISSN:0918-2918

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    <p>A 73-year-old man previously treated with rituximab for his mucosa-associated lymphoid tissue lymphoma suffered a suboptimal humoral immune response against an acquired SARS-CoV-2 infection. A detailed serological description revealed discrepant antigen-specific humoral immune responses. The titer of spike-targeting, "viral-neutralizing" antibodies remained below the detection level, in contrast to the anti-nucleocapsid, "binding" antibody response, which was comparable in both magnitude and kinetics. Accordingly, viral neutralizability and clearance was delayed, leading to prolonged RNAemia and persistent pneumonia. The present case highlights the need to closely monitor this unique population of recipients of B-cell-targeted therapies for their neutralizing antibody responses against SARS-CoV-2. </p>

    DOI: 10.2169/internalmedicine.7884-21

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    CiNii Article

  • Diffuse large B-cell lymphoma with markedly improved chylothorax by lymphangiography

    MORIGUCHI Makoto, TAKAKUWA Teruhito, KAGEYAMA Ken, OKAMURA Hiroshi, NANNO Satoru, NISHIMOTO Mitsutaka, NAKASHIMA Yasuhiro, KOH Hideo, NAKANE Takahiko, YAMAMOTO Akira, NAKAMAE Hirohisa, HINO Masayuki

    Rinsho Ketsueki   62 ( 6 )   554 - 559   2021( ISSN:0485-1439

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    <p>Chylothorax is a rare clinical sign in patients with diffuse large B-cell lymphoma (DLBCL), which is often challenging to manage and has a poor prognosis. We report the case of a 59-year-old woman who presented with right pleural effusion at the time of DLBCL diagnosis. Lymphadenopathy rapidly improved in response to chemotherapy. However, the pleural effusion progressed and was identified as chylothorax by thoracentesis. Because attempts to manage the condition with fasting and central venous nutrition were unsuccessful, we performed ultrasound-guided intranodal lipiodol lymphangiography from the inguinal lymph node. Although leak sites were not detected, the pleural effusion markedly improved on the day after the examination and resolved after 2 months. Lymphangiography is a minimally invasive examination with few complications. It contributes not only to the identification of leak sites but also to the improvement and resolution of chylothorax. Therefore, lymphangiography should be considered for refractory chylothorax that is unresponsive to chemotherapy or nutritional management.</p>

    DOI: 10.11406/rinketsu.62.554

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    CiNii Article

  • Current Status and Needs of Long-term Follow-up Clinics for Hematopoietic Cell Transplant Survivors: Results of a Nationwide Survey in Japan Reviewed

    Kurosawa Saiko, Mori Ayako, Tsukagoshi Mayumi, Onishi Yasushi, Ohwada Chikako, Mori Takehiko, Goto Hideki, Asano-Mori Yuki, Nawa Yuichiro, Hino Masayuki, Fukuchi Tomoko, Mori Yasuo, Yamahana Reiko, Inamoto Yoshihiro, Fukuda Takahiro

    BONE MARROW TRANSPLANTATION   55 ( SUPPL 1 )   617 - 618   2020.12( ISSN:0268-3369

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  • Retrospective Multi-center Study of Adolescent and Young Adult (AYA) Multiple Myeloma in Kansai Myeloma Forum Registry Reviewed

    Nakaya Aya, Kohara Takae, Shibayama Hirohiko, Onda Yoshiyuki, Kanda Junya, Kaneko Hitomi, Imada Kazunori, Kida Toru, Kosugi Satoru, Ishikawa Jun, Yamamura Ryosuke, Shimazu Yutaka, Tanaka Hirokazu, Fuchida Shin-Ichi, Shimura Yuji, Kiyota Miki, Wada Katsuya, Ito Tomoki, Uoshima Nobuhiko, Yagi Hideo, Yoshihara Satoshi, Ohta Kensuke, Shimazaki Chihiro, Hino Masayuki, Takaori-Kondo Akifumi, Kuroda Junya, Matsumura Itaru, Kanakura Yuzuru, Nomura Shosaku

    BONE MARROW TRANSPLANTATION   55 ( SUPPL 1 )   560 - 561   2020.12( ISSN:0268-3369

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  • Effect of Prophylactic Post-transplant Ponatinib Administration on Outcomes in Patients With Philadelphia Chromosome-positive Acute Lymphoblastic Leukemia Reviewed

    Nanno Satoru, Matsumoto Kana, Nakamae Mika, Okamura Hiroshi, Nishimoto Mitsutaka, Hirose Asao, Koh Hideo, Nakashima Yasuhiro, Nakane Takahiko, Morita Kunihiko, Hino Masayuki, Nakamae Hirohisa

    CLINICAL LYMPHOMA MYELOMA & LEUKEMIA   20 ( 12 )   813 - +   2020.12( ISSN:2152-2650

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    DOI: 10.1016/j.clml.2020.07.005

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  • Effect of allogeneic HCT from unrelated donors in AML patients with intermediate- or poor-risk cytogenetics: a retrospective study from the Japanese Society for HCT Reviewed

    Yamasaki Satoshi, Mori Jinichi, Kanda Junya, Imahashi Nobuhiko, Uchida Naoyuki, Doki Noriko, Tanaka Masatsugu, Katayama Yuta, Eto Tetsuya, Ozawa Yukiyasu, Takada Satoru, Onizuka Makoto, Hino Masayuki, Kanda Yoshinobu, Fukuda Takahiro, Atsuta Yoshiko, Yanada Masamitsu

    ANNALS OF HEMATOLOGY   99 ( 12 )   2927 - 2937   2020.12( ISSN:0939-5555

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    DOI: 10.1007/s00277-020-04261-6

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  • Acquired Gray Platelet Syndrome Associated with Primary Myelofibrosis

    Ido Kentaro, Nakane Takahiko, Tanizawa Nao, Makuuchi Yosuke, Okamura Hiroshi, Koh Shiro, Nanno Satoru, Nishimoto Mitsutaka, Hirose Asao, Nakamae Mika, Nakashima Yasuhiro, Koh Hideo, Hino Masayuki, Nakamae Hirohisa

    Internal Medicine   59 ( 21 )   2751 - 2756   2020.11( ISSN:0918-2918

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    <p>A 53-year-old man presented with uncontrolled bleeding caused by acquired platelet dysfunction accompanied by calreticulin-mutated primary myelofibrosis. Based on the detection of abnormal platelets, including large gray platelets, under light microscopy and the loss of the second wave of aggregation observed by light transmission aggregometry, the patient was diagnosed with platelet dysfunction accompanied by myeloproliferative neoplasms (MPNs). In addition, the absence of platelet α-granules was confirmed by electron microscopy. Therefore, this condition may be termed "acquired gray platelet syndrome." Acquired platelet dysfunction must be ruled out when abnormal platelets are observed in patients with MPNs. </p>

    DOI: 10.2169/internalmedicine.4912-20

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    CiNii Article

  • Retrospective analysis of plasmacytoma in Kansai Myeloma Forum Registry. Reviewed

    Nakaya A, Tanaka H, Yagi H, Ohta K, Shibayama H, Kohara T, Kanda J, Shindo M, Shimura Y, Kosugi S, Kida T, Kaneko H, Imada K, Karasuno T, Matsuda M, Iida M, Adachi Y, Fuchida SI, Uoshima N, Uchiyama H, Takahashi R, Matsui T, Wada K, Kiyota M, Shimazaki C, Hino M, Kuroda J, Kanakura Y, Takaori-Kondo A, Nomura S, Matsumura I, Kansai Myeloma Forum Investigators.

    International journal of hematology   112 ( 5 )   666 - 673   2020.11( ISSN:0925-5710

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    DOI: 10.1007/s12185-020-02961-3

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  • 原発性骨髄線維症に伴う後天性灰色血小板症候群(Acquired Gray Platelet Syndrome Associated with Primary Myelofibrosis)

    Ido Kentaro, Nakane Takahiko, Tanizawa Nao, Makuuchi Yosuke, Okamura Hiroshi, Koh Shiro, Nanno Satoru, Nishimoto Mitsutaka, Hirose Asao, Nakamae Mika, Nakashima Yasuhiro, Koh Hideo, Hino Masayuki, Nakamae Hirohisa

    Internal Medicine   59 ( 21 )   2751 - 2756   2020.11( ISSN:0918-2918

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    症例は53歳男性で、2年前にカルレティキュリン変異原発性骨髄線維症(PMF)と診断され、無治療で経過観察とされていた。PMFが増悪し、触知可能な脾腫も認めるようになったため、同種造血細胞移植(allo-HCT)の適応となった。増悪コントロールのために3ヵ月前にルキソリチニブとヒドロキシカルバミドの投与を開始したが、大量の腹水が出現して入院した。入院時の評価では出血リスクは低いと考え、入院当日と入院5日目に腹膜穿刺を行った。入院7日目、重度貧血となり、腹壁のコントロール不良出血が判明した。入院12日目、中心静脈カテーテルを挿入したが、挿入部にコントロール不良の出血が出現した。止血または凝固障害が疑われ、精査の結果、PMFに伴う後天性血小板機能障害と診断した。電子顕微鏡で血小板α顆粒の欠如が確認され、病態は後天性灰色血小板症候群であると考えられた。入院の1ヵ月後、allo-HCTを行った。移植後46日目に好中球生着を達成したが、血小板生着は達成せず、移植後112日目に特発性肺炎症候群により死亡した。

  • 関西骨髄腫フォーラム登録における形質細胞腫の後方視的解析(Retrospective analysis of plasmacytoma in Kansai Myeloma Forum Registry)

    Nakaya Aya, Tanaka Hirokazu, Yagi Hideo, Ohta Kensuke, Shibayama Hirohiko, Kohara Takae, Kanda Junya, Shindo Maki, Shimura Yuji, Kosugi Satoru, Kida Toru, Kaneko Hitomi, Imada Kazunori, Karasuno Takahiro, Matsuda Mitsuhiro, Iida Masato, Adachi Yoko, Fuchida Shin-ichi, Uoshima Nobuhiko, Uchiyama Hitoji, Takahashi Ryoichi, Matsui Toshimitsu, Wada Katsuya, Kiyota Miki, Shimazaki Chihiro, Hino Masayuki, Kuroda Junya, Kanakura Yuzuru, Takaori-Kondo Akifumi, Nomura Shosaku, Matsumura Itaru, Kansai Myeloma Forum Investigators

    International Journal of Hematology   112 ( 5 )   666 - 673   2020.11( ISSN:0925-5710

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    2019年12月までに関西骨髄腫フォーラムに登録された形質細胞異常増殖症患者3575例のうち、2002年10月~2018年9月に形質細胞腫と診断された患者51例の臨床的特徴について検討した。27例(年齢中央値67歳、男性48%)が孤発性骨形質細胞腫(SBP)、24例(年齢中央値70歳、男性63%)が髄外形質細胞腫(EMP)で、有病率はそれぞれ0.8%、0.7%であった。Mタンパク質は、SBPではIgGが最も多く(40%)、EMPでは非分泌性タンパク質が最も多かった(50%)。SBPの5年生存率は78.2%で、放射線療法と化学療法の併用療法を受けたSBPの5年生存率が最も高かった。EMPの5年生存率は80.8%で、未治療のEMPで5年生存率が最も高かった。SBPは44%が多発性骨髄腫(MM)に進行し、診断からの期間の中央値は10.5ヵ月であり、EMPは8%がMMに進行し、診断からの期間の中央値は18.6ヵ月であった。治療法は、SBPでは放射線治療(41%)または経過観察(41%)が最も多く、EMPでは化学療法(54%)が最も多かった。年齢、性別、パフォーマンスステータス、IgG Mタンパク質の予後因子を単変量解析したところ、統計的に有意な差は認められなかった。

  • Clinical usefulness of very high serum soluble interleukin-2 receptor levels for the detection of tuberculous peritonitis in a patient with chronic myelogenous leukemia Reviewed

    Moriguchi Makoto, Koh Hideo, Hayashi Tetsuya, Okamura Hiroshi, Nanno Satoru, Nakashima Yasuhiro, Nakane Takahiko, Imoto Waki, Yamada Koichi, Kakeya Hiroshi, Hino Masayuki, Nakamae Hirohisa

    JOURNAL OF INFECTION AND CHEMOTHERAPY   26 ( 10 )   1054 - 1057   2020.10( ISSN:1341-321X

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    DOI: 10.1016/j.jiac.2020.05.001

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  • 同種造血幹細胞移植後にみられた赤血球増加症 Reviewed

    川原 宏惠, 高桑 輝人, 中前 美佳, 久保田 浩, 岡村 浩史, 南野 智, 中嶋 康博, 中根 孝彦, 康 秀男, 廣瀬 朝生, 日野 雅之, 中前 博久

    (一社)日本血液学会-東京事務局 臨床血液   61 ( 10 )   1492 - 1496   2020.10( ISSN:0485-1439

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    移植後赤血球増加症(PTE)が同種造血幹細胞移植後に生じることは稀であり,臨床的特徴は不明な部分が多い。当院で1992年1月〜2011年12月の間に同種造血幹細胞移植を行った321例のうち3例のPTE患者の臨床的特徴について検討を行った。3例はいずれもヘモグロビン最大時の白血球数および血小板数は正常範囲内であった。エリスロポエチンは2例で測定され,ともに正常範囲内であった。3例ともに細胞減少療法や抗血小板薬投与は行わずに血栓症や出血のイベントはなかった。3例はいずれもJAK2V617F変異陰性であったが,2例はJAK/STAT経路の上流シグナルであるIL-13が高値を示した。真性多血症ではJAK2遺伝子の変異が病態に大きく寄与していることが知られているが,PTEでは病態が異なる可能性がある。今後の症例集積により同種移植後PTEの適切なマネジメントを構築する必要があると考える。(著者抄録)

  • Retrospective multi-center study of Adolescent and Young Adult (AYA) Multiple Myeloma in Kansai Myeloma Forum registry. Reviewed

    Nakaya A, Kohara T, Shibayama H, Onda Y, Kanda J, Kaneko H, Imada K, Kida T, Kosugi S, Ishikawa J, Yamamura R, Shimazu Y, Tanaka H, Fuchida SI, Shimura Y, Kiyota M, Wada K, Ito T, Uoshima N, Yagi H, Yoshihara S, Ohta K, Shimazaki C, Hino M, Takaori-Kondo A, Kuroda J, Matsumura I, Kanakura Y, Nomura S, Kansai Myeloma Forum Investigators.

    International journal of hematology   112 ( 4 )   435 - 438   2020.10( ISSN:0925-5710

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    DOI: 10.1007/s12185-020-02996-6

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  • 慢性骨髄性白血病患者の結核性腹膜炎検出目的において、非常に高値である血中可溶性インターロイキン2受容体の臨床的有用性(Clinical usefulness of very high serum soluble interleukin-2 receptor levels for the detection of tuberculous peritonitis in a patient with chronic myelogenous leukemia)

    Moriguchi Makoto, Koh Hideo, Hayashi Tetsuya, Okamura Hiroshi, Nanno Satoru, Nakashima Yasuhiro, Nakane Takahiko, Imoto Waki, Yamada Koichi, Kakeya Hiroshi, Hino Masayuki, Nakamae Hirohisa

    Journal of Infection and Chemotherapy   26 ( 10 )   1054 - 1057   2020.10( ISSN:1341-321X

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    症例は59歳女性で、白血球増加と血小板増加を主訴とした。入院初日(HD1)、白血球・血小板増加、LDH、CRP、AST、ALT値上昇が認められた。HD4に実施したIGRAとT-SPOT.TB試験は陰性であった。骨髄生検により有意な線維症を伴う骨髄球過形成、巨核球過形成が認められた。蛍光in situハイブリダイゼーションによりフィラデルフィア転座が検出された。造影CTにより大量の腹水と肝脾腫大が認められた。HD9に血中のMajor BCR/ABL1 mRNA(IS)の陽性所見に基づいて慢性骨髄性白血病と診断した。HD22の腹腔穿刺により半透明の黄色い液体が認められ、アデノシンデアミナーゼ値はカットオフ値以上であった。HD18に、血清中に極めて高値の可溶性インターロイキン2受容体(sIL-2R)値が観察された。心肺機能低下のため悪性リンパ腫を疑い、HD29にメチルプレドニゾロンパルス療法を開始したが、結核の家族歴があったことからHD32にレボフロキサシン、イソニアジド、ストレプトマイシンを静脈内投与した。腹水の培養検査結果に基づき、HD39に結核性腹膜炎と診断した。抗結核治療により血清中のsIL-2R値は顕著に低下し、腹水量も改善した。

  • 関西骨髄腫フォーラムレジストリにおける思春期・若年成人(AYA世代)の多発性骨髄腫に関する後方視的多施設共同研究(Retrospective multi-center study of Adolescent and Young Adult(AYA) Multiple Myeloma in Kansai Myeloma Forum registry)

    Nakaya Aya, Kohara Takae, Shibayama Hirohiko, Onda Yoshiyuki, Kanda Junya, Kaneko Hitomi, Imada Kazunori, Kida Toru, Kosugi Satoru, Ishikawa Jun, Yamamura Ryosuke, Shimazu Yutaka, Tanaka Hirokazu, Fuchida Shin-ichi, Shimura Yuji, Kiyota Miki, Wada Katsuya, Ito Tomoki, Uoshima Nobuhiko, Yagi Hideo, Yoshihara Satoshi, Ohta Kensuke, Shimazaki Chihiro, Hino Masayuki, Takaori-Kondo Akifumi, Kuroda Junya, Matsumura Itaru, Kanakura Yuzuru, Nomura Shosaku

    International Journal of Hematology   112 ( 4 )   435 - 438   2020.10( ISSN:0925-5710

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    1998年4月~2018年5月に関西骨髄腫フォーラムに登録された、症候性多発性骨髄腫(MM)の思春期・若年成人(AYA世代)患者26例(男性50%、年齢20~39歳)を対象に、臨床的特徴と転帰を後方視的に解析した。M蛋白のタイプは、IgG(45%)、Bence Jones蛋白(33%)、IgA(11%)、非分泌型(7%)、IgD(4%)であった。国際病期分類のステージI、II、IIIはそれぞれ43%、38%、19%であった。ハイリスクの染色体異常であるdel(17p)が3例、t(14;16)が2例に認められた。最も頻度の高いCRAB(高カルシウム血症、腎不全、貧血、骨病変)は、骨病変の18例で、腎不全が11例、貧血6例、高カルシウム血症1例であった。患者の81%に施行された幹細胞移植(SCT)の内訳は、39%が自己幹細胞移植(auto-SCT)、23%がauto-SCTと同種幹細胞移植(allo-SCT)の併用、19%がallo-SCTであった。患者全体の5年生存率は71%であり、治療別では、auto-SCTとallo-SCTの併用で83.3%、auto-SCTで77.8%、SCTを行わない化学療法で75.5%、allo-SCTで40.0%であった。重篤な晩発性の有害事象として、二次乳癌1例、アミロイドーシス2例、心血管イベント2例が発生した。

  • The critical role of CD4(+) T cells in PD-1 blockade against MHC-II-expressing tumors such as classic Hodgkin lymphoma Reviewed

    Nagasaki Joji, Togashi Yosuke, Sugawara Takeaki, Itami Makiko, Yamauchi Nobuhiko, Yuda Junichiro, Sugano Masato, Ohara Yuuki, Minami Yosuke, Nakamae Hirohisa, Hino Masayuki, Takeuchi Masahiro, Nishikawa Hiroyoshi

    BLOOD ADVANCES   4 ( 17 )   4069 - 4082   2020.09( ISSN:2473-9529

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    DOI: 10.1182/bloodadvances.2020002098

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  • Successful treatment with baloxavir marboxil of a patient with peramivir-resistant influenza A/H3N2 with a dual E119D/R292K substitution after allogeneic hematopoietic cell transplantation: a case report Reviewed

    Harada Naonori, Shibata Wataru, Koh Hideo, Takashita Emi, Fujisaki Seiichiro, Okamura Hiroshi, Nanno Satoru, Yamada Koichi, Nakamae Hirohisa, Hino Masayuki, Kakeya Hiroshi

    BMC INFECTIOUS DISEASES   20 ( 1 )   478   2020.07

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    DOI: 10.1186/s12879-020-05205-1

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  • Mosquito allergy: a novel strong prognostic symptom of outcome after allogeneic hematopoietic transplantation Reviewed

    Koh Shiro, Nakamae Hirohisa, Nanno Satoru, Nakane Takahiko, Nakashima Yasuhiro, Koh Hideo, Nakamae Mika, Hirose Asao, Hino Masayuki

    BONE MARROW TRANSPLANTATION   55 ( 7 )   1509 - 1511   2020.07( ISSN:0268-3369

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41409-019-0759-y

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  • Phase 2 study of bosutinib in Japanese patients with newly diagnosed chronic phase chronic myeloid leukemia Reviewed

    Hino Masayuki, Matsumura Itaru, Fujisawa Shin, Ishizawa Kenichi, Ono Takaaki, Sakaida Emiko, Sekiguchi Naohiro, Tanetsugu Yusuke, Fukuhara Kei, Ohkura Masayuki, Koide Yuichiro, Takahashi Naoto

    INTERNATIONAL JOURNAL OF HEMATOLOGY   112 ( 1 )   24 - 32   2020.07( ISSN:0925-5710

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s12185-020-02878-x

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  • 慢性期慢性骨髄性白血病と新規に診断された日本人患者を対象とするボスチニブの第II相試験(Phase 2 study of bosutinib in Japanese patients with newly diagnosed chronic phase chronic myeloid leukemia)

    Hino Masayuki, Matsumura Itaru, Fujisawa Shin, Ishizawa Kenichi, Ono Takaaki, Sakaida Emiko, Sekiguchi Naohiro, Tanetsugu Yusuke, Fukuhara Kei, Ohkura Masayuki, Koide Yuichiro, Takahashi Naoto

    International Journal of Hematology   112 ( 1 )   24 - 32   2020.07( ISSN:0925-5710

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    慢性期慢性骨髄性白血病(CP CML)と新規に診断された日本人患者に対するボスチニブの有効性、安全性、薬物動態を評価する第II相試験を実施した。CP CMLと新規に診断した患者60例(男性36例、女性24例、年齢20~83歳)に対し、ボスチニブ400mgを1日1回投与し、12ヵ月後の分子遺伝学的大寛解(MMR)を評価した。全例がフィラデルフィア染色体陽性で、e13a2/e14a2転写物を有していた。経過観察期間中(中央値16.6ヵ月)、41例がボスチニブ投与を継続した。12ヵ月時点のMMR率は55.0%であった。治療中に移行期/急性転化期に転換した例はなく、治療中またはボスチニブの最終投与後28日以内に死亡した患者はいなかった。治療による最も一般的な有害事象は、下痢が86.7%、アラニンアミノトランスフェラーゼ増加が55.0%、アスパラギン酸アミノトランスフェラーゼ増加が46.7%であった。ボスチニブ投与は新規診断日本人CP CML患者に対して有効なファーストライン治療法であることが示唆された。

  • Interactive web application for plotting personalized prognosis prediction curves in allogeneic hematopoietic cell transplantation using machine learning. Reviewed

    Okamura H, Nakamae M, Koh S, Nanno S, Nakashima Y, Koh H, Nakane T, Hirose A, Hino M, Nakamae H

    Transplantation   2020.06( ISSN:0041-1337

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    DOI: 10.1097/TP.0000000000003357

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  • Health-related quality of life in peripheral blood stem cell donors and bone marrow donors: a prospective study in Japan Reviewed

    Fujimoto Ayumi, Suzuki Ritsuro, Orihara Katsumi, Iida Minako, Yamashita Takuya, Nagafuji Koji, Kanamori Heiwa, Kodera Yoshihisa, Miyamura Koichi, Okamoto Shinichiro, Hino Masayuki

    INTERNATIONAL JOURNAL OF HEMATOLOGY   111 ( 6 )   840 - 850   2020.06( ISSN:0925-5710

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s12185-020-02852-7

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  • Post-Treatment M2BPGi Level and the Rate of Autotaxin Reduction are Predictive of Hepatocellular Carcinoma Development after Antiviral Therapy in Patients with Chronic Hepatitis C Reviewed

    Takemura Kazuya, Takizawa Etsuko, Tamori Akihiro, Nakamae Mika, Kubota Hiroshi, Uchida-Kobayashi Sawako, Enomoto Masaru, Kawada Norifumi, Hino Masayuki

    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES   21 ( 12 )   2020.06

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.3390/ijms21124517

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  • 末梢血幹細胞ドナーと骨髄ドナーの健康関連QOL 日本における前向き研究(Health-related quality of life in peripheral blood stem cell donors and bone marrow donors: a prospective study in Japan)

    Fujimoto Ayumi, Suzuki Ritsuro, Orihara Katsumi, Iida Minako, Yamashita Takuya, Nagafuji Koji, Kanamori Heiwa, Kodera Yoshihisa, Miyamura Koichi, Okamoto Shinichiro, Hino Masayuki

    International Journal of Hematology   111 ( 6 )   840 - 850   2020.06( ISSN:0925-5710

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    末梢血幹細胞(PBSC)ドナーと骨髄(BM)ドナーにみられる健康関連QOL(HRQOL)と有害事象の発現状況を比較検討した。PBSCドナー107例(男性78例、女性29例、中央値37歳)、BMドナー108例(男性57例、女性51例、中央値39歳)を対象に、前向き観察研究を実施した。HRQOLに関するSF-36スコアにベースライン時ではPBSC群とBM群の間に有意差はみられなかったが、採取後1週の時点で身体スコアはBM群の方が有意に低く、精神状況スコアもBM群の方が有意に低かった。3ヵ月後にはBM群のスコアの回復がみられ、有意な群間差はなかった。有害事象の検討では、採取前にBM群で採取部痛、PBSC群でG-CSF投与に伴う腰痛が最も多く、全有害事象の発現率はPBSC群の方が有意に高かった。一方、採取当日の有害事象の発現率に有意な群間差はみられず、採取後の発現率はBM群の方がPBSC群より有意に高値を示していた。また、BM群ではベースライン時における身体スコア低値、女性および若年が採取時にみられる中等度~重度の有害事象と関連しており、PBSC群では身体スコア、精神スコアとの関連はみられず、採取時の中等度~重度の有害事象に関わるリスク因子として女性のみが抽出された。

  • Long-term efficacy and safety of ruxolitinib versus best available therapy in polycythaemia vera (RESPONSE): 5-year follow up of a phase 3 study Reviewed International coauthorship

    Kiladjian JJ, Zachee P, Hino M, Pane F, Masszi T, Harrison CN, Mesa R, Miller CB, Passamonti F, Durrant S, Griesshammer M, Kirito K, Besses C, Moiraghi B, Rumi E, Rosti V, Blau IW, Francillard N, Dong T, Wroclawska M, Vannucchi AM, Verstovsek S

    Lancet Haematol   7 ( 3 )   226 - 237   2020.05

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    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

  • Current Status and Needs of Long-Term Follow-Up Clinics for Hematopoietic Cell Transplantation Survivors: Results of a Nationwide Survey in Japan Reviewed

    Kurosawa Saiko, Mori Ayako, Tsukagoshi Mayumi, Onishi Yasushi, Ohwada Chikako, Mori Takehiko, Goto Hideki, Asano-Mori Yuki, Nawa Yuichiro, Hino Masayuki, Fukuchi Tomoko, Mori Yasuo, Yamahana Reiko, Inamoto Yoshihiro, Fukuda Takahiro

    BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION   26 ( 5 )   949 - 955   2020.05( ISSN:1083-8791

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.bbmt.2020.01.008

    PubMed

  • Treatment-free remission after first-line dasatinib discontinuation in patients with chronic myeloid leukaemia (first-line DADI trial): a single-arm, multicentre, phase 2 trial Reviewed

    Kimura S, Imagawa J, Murai K, Hino M, Kitawaki T, Okada M, Tanaka H, Shindo M, Kumagai T, Ikezoe T, Uoshima N, Sato T, Watanabe R, Kowata S, Hayakawa M, Hosoki T, Ikeda K, Kobayashi T, Kakinoki Y, Nishimoto T, Takezako N, Shibayama H, Takaori-Kondo A, Nakamae H, Kawaguchi A, Ureshino H, Sakamoto J, Ishida Y; DADI Trial Group

    Lancet Haematol   7 ( 3 )   218 - 225   2020.05

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  • Donor KIR2DS1-Mediated Decreased Relapse and Improved Survival Depending on Remission Status at HLA-Haploidentical Transplantation with Post-Transplantation Cyclophosphamide Reviewed

    Ido Kentaro, Koh Hideo, Hirose Asao, Okamura Hiroshi, Koh Shiro, Nanno Satoru, Nishimoto Mitsutaka, Nakamae Mika, Nakashima Yasuhiro, Nakane Takahiko, Hino Masayuki, Nakamae Hirohisa

    BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION   26 ( 4 )   723 - 733   2020.04( ISSN:1083-8791

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.bbmt.2019.12.765

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  • Pretransplant serum beta-2 microglobulin level is a potential novel prognostic marker of overall survival after allogeneic hematopoietic cell transplantation - a retrospective observational study Reviewed

    Harada Naonori, Nakane Takahiko, Nakamae Mika, Hashimoto Yoshinori, Okamura Hiroshi, Nanno Satoru, Nishimoto Mitsutaka, Hirose Asao, Nakashima Yasuhiro, Koh Hideo, Hino Masayuki, Nakamae Hirohisa

    TRANSPLANT INTERNATIONAL   33 ( 4 )   391 - 401   2020.04( ISSN:0934-0874

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/tri.13564

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  • Treatment-free remission after first-line dasatinib discontinuation in patients with chronic myeloid leukaemia (first-line DADI trial): a single-arm, multicentre, phase 2 trial Reviewed

    Kimura Shinya, Imagawa Jun, Murai Kazunori, Hino Masayuki, Kitawaki Toshio, Okada Masaya, Tanaka Hideo, Shindo Motohiro, Kumagai Takashi, Ikezoe Takayuki, Uoshima Nobuhiko, Sato Tsutomu, Watanabe Reiko, Kowata Shugo, Hayakawa Masaya, Hosoki Takaaki, Ikeda Kazuhiko, Kobayashi Tsutomu, Kakinoki Yasutaka, Nishimoto Tetsuo, Takezako Naoki, Shibayama Hirohiko, Takaori-Kondo Akifumi, Nakamae Hirohisa, Kawaguchi Atsushi, Ureshino Hiroshi, Sakamoto Junichi, Ishida Yoji

    LANCET HAEMATOLOGY   7 ( 3 )   E218 - E225   2020.03( ISSN:2352-3026

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/S2352-3026(19)30235-2

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  • 同種造血細胞移植後難治性ウイルス血症・感染症に対する高用量polyclonal intravenous immunoglobulin Reviewed

    井戸 健太郎, 中根 孝彦, 岡村 浩史, 南野 智, 西本 光孝, 廣瀬 朝生, 中前 美佳, 中嶋 康博, 康 秀男, 日野 雅之, 中前 博久

    (一社)日本血液学会-東京事務局 臨床血液   61 ( 3 )   215 - 222   2020.03( ISSN:0485-1439

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    我々は致死的合併症の一つである同種造血細胞移植後難治性ウイルス血症・感染症に対するpolyclonal intravenous immunoglobulin(polyclonal IVIG)400mg/kg/日連続5日間投与の有効性・安全性を評価するためにこの前向きパイロット試験を計画した。14例の試験参加者は全例介入を受けた。Human parvovirus B19血症あるいは高リスクrespiratory syncytial virus肺炎/気管支炎といった外因性ウイルス血症・感染症に対して投与された3例は全例complete responseに到達した。1例でIVIG開始後2日に心不全が観察された。結論として,本研究は高用量polyclonal IVIGが同種造血細胞移植後のとくに,難治性外因性ウイルス感染症に対して有効である可能性を示唆している。(著者抄録)

  • A noninvasive diagnostic approach using per-rectal portal scintigraphy for sinusoidal obstruction syndrome after allogeneic hematopoietic cell transplantation. Reviewed

    Okamura H, Koh H, Takakuwa T, Ido K, Makuuchi Y, Ine S, Nanno S, Nakashima Y, Nakane T, Jogo A, Yamamoto A, Hamuro M, Kotani K, Kawabe J, Higashiyama S, Yoshida A, Shiomi S, Ohsawa M, Hino M, Nakamae H.

    Bone Marrow Transplant.   55 ( 2 )   470 - 472   2020.02

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    類洞閉塞症候群(SOS)は、黄疸、腹水、右季肋部痛などの症状を呈する同種造血細胞移植後早期の致死的合併症であるが、鑑別診断が多く診断には困難が伴う。門脈圧亢進がSOSの特徴的所見であることから、我々は非侵襲的門脈圧測定法である経直腸門脈シンチグラフィーがSOS診断に有用であるか否かを検討した結果、高精度にSOS診断が可能であった。経直腸門脈シンチグラフィーはSOS診断に有用である可能性がある。

  • Safety profile of the concomitant use of foscarnet and aerosolized pentamidine in allogeneic hematopoietic stem cell transplantation recipients Reviewed

    Takahashi Masaya, Takahashi Katsuyuki, Inose Ryo, Sugimoto Takashi, Koh Hideo, Hino Masayuki, Nagayama Katsuya

    TRANSPLANT INFECTIOUS DISEASE   22 ( 1 )   e13239   2020.02( ISSN:1398-2273

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/tid.13239

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  • Clinical Characteristics of Rapidly Progressive Fatal Hemorrhagic Pneumonia Caused by Stenotrophomonas maltophilia Reviewed

    Imoto W, Yamada K, Yamairi K, Shibata W, Namikawa H, Yukawa S, Yoshii N, Nakaie K, Hirose A, Koh H, Watanabe T, Asai K, Nakamae H, Kaneko Y, Kawaguchi T, Hino M, Kakeya H

    Intern Med   59 ( 2 )   193 - 198   2020.02

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  • Current status and needs of long-term follow-up clinics for hematopoietic cell transplant survivors: results of a nationwide survey in Japan Reviewed

    Kurosawa S, Mori A, Tsukagoshi M, Onishi Y, Ohwada C, Mori T, Goto H, Asano-Mori Y, Nawa Y, Hino M, Fukuchi T, Mori Y, Yamahana R, Inamoto Y, Fukuda T

    Biol Blood Marrow Transplant   2020.01

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    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

  • 経気管支肺胞生検で診断できた肺浸潤を伴う急性単球性白血病 Reviewed

    原田 尚憲, 中根 孝彦, 岡村 浩史, 南野 智, 中嶋 康博, 康 秀男, 田中 さやか, 大澤 政彦, 日野 雅之, 中前 博久

    臨床血液   61 ( 1 )   27 - 32   2020.01

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  • Stenotrophomonas maltophiliaにより引き起こされた急速進行性致死性出血性肺炎の臨床的特徴(Clinical Characteristics of Rapidly Progressive Fatal Hemorrhagic Pneumonia Caused by Stenotrophomonas maltophilia)

    Imoto Waki, Yamada Koichi, Yamairi Kazushi, Shibata Wataru, Namikawa Hiroki, Yukawa Satomi, Yoshii Naoko, Nakaie Kiyotaka, Hirose Asao, Koh Hideo, Watanabe Tetsuya, Asai Kazuhisa, Nakamae Hirohisa, Kaneko Yukihiro, Kawaguchi Tomoya, Hino Masayuki, Kakeya Hiroshi

    Internal Medicine   59 ( 2 )   193 - 198   2020.01( ISSN:0918-2918

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    Stenotrophomonas maltophilia(SM)菌血症で入院した35例の医療データを用いて、SMによる出血性肺炎の予測因子を後向きに評価した。4例(男性3例、女性1例、中央値56.2歳)で出血性肺炎を認め、31例(男性19例、女性12例、中央値59.5歳)は出血性肺炎を認めなかった。出血性肺炎を認めた患者は認めなかった患者に比べて悪性血液疾患の割合が有意に高く(100 vs 38.7%)、血小板減少症の割合が有意に高く(100 vs 38.7%)、30日以内のキノロン系薬使用率が有意に高かった(75 vs 19.4%)。入院中の死亡率は、出血性肺炎を認めた患者100%、認めなかった患者32.3%であった(p=0.02)。悪性血液疾患、血小板減少症、30日以内のキノロン系薬使用歴のあるSM菌血症患者では慎重に治療を行う必要があることが示された。

  • Academia's Initiative to Create Innovation: Those Who Master Regulation Achieve Innovation Reviewed

    KUSAKABE Tetsuya, TATEISHI Chiharu, FUJII Hisako, NISHIKAWA Takeshi, MINAMI Chikako, NISHIU Mieko, HINO Masayuki

    Society for Regulatory Science of Medical Products, Regulatory Science of Medical Products   10 ( 3 )   139 - 152   2020( ISSN:2185-7113

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    <p>Pharmaceuticals and Medical Devices Act (PMD Act) regulates the pharmaceutical products including drugs, medical devices and other related products, and strictly controls new product development, review and approval processes, manufacturing, and post-marketing studies. To achieve medical innovations, researchers in academia as well as those in pharmaceutical industry should be well informed about pharmaceutical regulations and are required to comply with regulatory requirements when conducting preclinical and clinical studies for medical product development. In recent years, academic research organizations (AROs) have been established as university-based organizations that support throughout the process from basic research to practical application, in particular, guiding clinical research and trials in order to promote the development of new pharmaceutical products using academic research findings. Especially in the open innovation model, universities are expected to play an important role. At Osaka City University, we have expanded various research-related ARO functions and services with the catch phrase "Those who master regulation achieve innovation." In this article, we introduce the institution profile, services and functions of Center for Clinical Research and Innovation (CCRI), an ARO housed in Osaka City University Hospital, and its initiatives to produce innovations from academic research. Academia's involvement in regulations that interpenetrate with innovations is also discussed.</p>

    DOI: 10.14982/rsmp.10.139

    CiNii Article

  • Erythrocytosis following allogeneic hematopoietic stem cell transplantation

    KAWAHARA Hiroe, TAKAKUWA Teruhito, NAKAMAE Mika, KUBOTA Hiroshi, OKAMURA Hiroshi, NANNO Satoru, NAKASHIMA Yasuhiro, NAKANE Takahiko, KOH Hideo, HIROSE Asao, HINO Masayuki, NAKAMAE Hirohisa

    Rinsho Ketsueki   61 ( 10 )   1492 - 1496   2020( ISSN:0485-1439

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    <p>Post-transplant erythrocytosis (PTE) following allogeneic hematopoietic stem cell transplantation (alloHSCT) is rare, and the clinical characteristics of this condition remain unknown. In this study, we examined the clinical characteristics of three PTE cases among 321 patients who received allo HSCT from January 1992 to December 2011 at our institution. All three patients exhibited normal levels of white blood cell and platelet counts when their hemoglobin levels reached their peak. Two patients exhibited normal levels of erythropoietin. No thrombosis or hemorrhage was observed in any of the three patients without cytoreductive therapy or an antiplatelet agent. All three patients tested negative for JAK2V617F mutations. Two patients had high levels of IL-13, an upstream signal for the JAK/STAT pathway. JAK2 is known to significantly contribute to the pathology of polycythemia vera; however, this pathology may differ from that of PTE. We believe that it is necessary to construct a more appropriate management structure for PTE by analyzing more case data in the future.</p>

    DOI: 10.11406/rinketsu.61.1492

    PubMed

    CiNii Article

  • High-dose polyclonal intravenous immunoglobulin therapy for refractory viral infections including viremia after allogeneic hematopoietic cell transplantation

    IDO Kentaro, NAKANE Takahiko, OKAMURA Hiroshi, NANNO Satoru, NISHIMOTO Mitsutaka, HIROSE Asao, NAKAMAE Mika, NAKASHIMA Yasuhiro, KOH Hideo, HINO Masayuki, NAKAMAE Hirohisa

    Rinsho Ketsueki   61 ( 3 )   215 - 222   2020( ISSN:0485-1439

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    <p>Refractory viremia/viral disease is a major life-threatening complication that may arise among patients undergoing allogeneic hematopoietic cell transplantation (allo-HCT). This study aimed to clarify the therapeutic effect of high-dose polyclonal intravenous immunoglobulin (IVIG) against viremia/viral diseases after allo-HCT. We conducted a pilot study to investigate the therapeutic effect of 400 mg/kg of IVIG given for 5 consecutive days against refractory viremia/viral disease after allo-HCT. Overall, 7 patients were drug-resistant and the other 7 had not previously received any drug for their viremia/viral disease. All patients completed the 5-day therapy regimen of IVIG. A complete response at Day 56 was observed for 8 of 14 patients (57.1%). Additionally, 10 of 14 patients (71.4%) were alive at Day 56, although only one death occurred due to the viremia/viral disease. Remarkably, all 3 cases who developed exogenous viremia/viral diseases including respiratory syncytial virus pneumonia/bronchitis and human parvovirus B19 viremia achieved a complete response, suggesting that high-dose polyclonal IVIG may be more effective against exogenous viruses rather than endogenous ones. Congestive heart failure was observed in 1 patient. High-dose polyclonal IVIG could be an effective and feasible therapy for refractory viremia/viral disease after allo-HCT.</p>

    DOI: 10.11406/rinketsu.61.215

    PubMed

    CiNii Article

  • Pulmonary infiltration of acute monoblastic leukemia diagnosed by transbronchial lung biopsy Reviewed

    HARADA Naonori, NAKANE Takahiko, OKAMURA Hiroshi, NANNO Satoru, NAKASHIMA Yasuhiro, KOH Hideo, TANAKA Sayaka, OHSAWA Masahiko, HINO Masayuki, NAKAMAE Hirohisa

    Rinsho Ketsueki   61 ( 1 )   27 - 32   2020( ISSN:0485-1439

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    <p>A 65-year-old woman was urgently admitted to our hospital for antibiotic-resistant fever, hypoxemia, and hyperleukocytosis and was diagnosed with acute monoblastic leukemia. Chest computed tomography revealed interlobular septal thickening, central ground-glass opacity, and a nodular shadow in the left lower lobe. Although several treatments for infectious disease and acute heart failure were administered, they were less effective. Transbronchial lung biopsy was performed on day 7 of hospitalization, and subsequently, pulmonary leukemic infiltration was confirmed. Based on the diagnosis, we decided to start intensive chemotherapy. Consequently, the abnormal lung shadow on computed tomography vanished, and complete hematological remission was achieved. Although acute myeloid leukemia is frequently associated with lung infiltration during onset, it is often difficult to distinguish it from other pulmonary complications. In clinical practice, intensive chemotherapy is often initiated based on the clinical evaluation without pathological confirmation of the lung disease. Our patient was accurately diagnosed based on the pulmonary leukemic infiltration observed pathologically and recovered well. Here we report our case along with a discussion of the relevant literature.</p>

    DOI: 10.11406/rinketsu.61.27

    PubMed

    CiNii Article

  • Donor KIR2DS1-mediated Decreased Relapse and Improved Survival, Depending on Remission Status at HLA-Haploidentical Transplantation with Post-transplantation Cyclophosphamide Reviewed

    Ido K, Koh H, Hirose A, Okamura H, Koh S, Nanno S, Nishimoto M, Nakamae M, Nakashima Y, Nakane T, Hino M, Nakamae H

    Biol Blood Marrow Transplant   2019.12

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  • Mosquito allergy: a novel strong prognostic symptom of outcome after allogeneic hematopoietic transplantation Reviewed

    Koh S, Nakamae H, Nanno S, Nakane T, Nakashima Y, Koh H, Nakamae M, Hirose A, Hino M

    Bone Marrow Transplant   2019.12

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  • Pretransplant serum beta-2 microglobulin level is a potential novel prognostic marker of overall survival after allogeneic hematopoietic cell transplantation - a retrospective observational study. Reviewed

    Harada N, Nakane T, Nakamae M, Hashimoto Y, Okamura H, Nanno S, Nishimoto M, Hirose A, Nakashima Y, Koh H, Hino M, Nakamae H

    Transpl Int   2019.12

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    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

  • Inotuzumab ozogamicin versus standard of care in Asian patients with relapsed/refractory acute lymphoblastic leukemia Reviewed International coauthorship

    Fujishima Naohito, Uchida Toshiki, Onishi Yasushi, Jung Chul Won, Goh Yeow Tee, Ando Kiyoshi, Wang Ming Chung, Ono Chiho, Matsumizu Miyako, Paccagnella M. Luisa, Sleight Barbara, Vandendries Erik, Fujii Yosuke, Hino Masayuki

    INTERNATIONAL JOURNAL OF HEMATOLOGY   110 ( 6 )   709 - 722   2019.12( ISSN:0925-5710

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    再発または難治性成人B細胞性急性リンパ性白血病(ALL)を対象として、イノツズマブオゾガマイシン(InO)と標準治療(SoC)を比較した国際非盲検無作為化第3相試験(INO-VATE)のアジア人患者のサブグループ解析を行った。SoC群に比較し、InO群で寛解率、最小残存病変陰性率が上回り、より多くの患者が造血幹細胞移植を受けることができ、全生存期間の中央値も延長した。類洞閉塞症候群はInO群で5人、SoC群で1人報告された。

    DOI: 10.1007/s12185-019-02749-0

    PubMed

  • Combination of Frailty Status and Comorbidity Score Improves the Stratification of Survival in Patients With Myelodysplastic Syndrome Owing to Good Predictive Capability for Infection-related Mortality. Reviewed

    Sakatoku K, Takeoka Y, Miura A, Araki T, Fujitani Y, Yamamura R, Nakamae H, Ohta K, Hino M

    Clinical lymphoma, myeloma & leukemia   19 ( 12 )   799 - 805   2019.12( ISSN:2152-2650

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    骨髄異形成症候群(MDS)患者におけるfrailtyや合併症の予後・死因に対する影響を
    調べた。118人の連続患者について後方視的に評価。Frailtyと合併症の増加に伴い感
    染関連死亡の発生率増加と全生存期間の増悪がみられた。この効果は、IPSS-Rが低い患者でより顕著であった。本研究は、frailtyおよび合併症が低リスクMDSにおいて感染症死亡・予後の独立した予測因子である可能性を示唆している。

    DOI: 10.1016/j.clml.2019.09.610

    PubMed

  • A prospective observational study of immune reconstitution following transplantation with post-transplant reduced-dose cyclophosphamide from HLA-haploidentical donors Reviewed

    Nakamae Hirohisa, Fujii Kazuki, Nanno Satoru, Okamura Hiroshi, Nakane Takahiko, Koh Hideo, Nakashima Yasuhiro, Nakamae Mika, Hirose Asao, Teshima Takanori, Hino Masayuki

    TRANSPLANT INTERNATIONAL   32 ( 12 )   1322 - 1332   2019.12( ISSN:0934-0874

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    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

    DOI: 10.1111/tri.13494

    PubMed

  • 日本人患者におけるHLA不一致非血縁ドナーからの同種造血細胞移植における、ボルテゾミブを含むGVHD予防に対する臨床第Ⅰ相試験 Reviewed

    10 ( 6 )   736 - 742   2019.12( ISSN:0925-5710

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    DOI: 10.1007/s12185-019-02743-6

    PubMed

  • 再発性/難治性急性リンパ芽球性白血病のアジア人患者におけるイノツズマブオゾガマイシンと標準治療の比較(Inotuzumab ozogamicin versus standard of care in Asian patients with relapsed/refractory acute lymphoblastic leukemia)

    Fujishima Naohito, Uchida Toshiki, Onishi Yasushi, Jung Chul Won, Goh Yeow Tee, Ando Kiyoshi, Wang Ming Chung, Ono Chiho, Matsumizu Miyako, Paccagnella M. Luisa, Sleight Barbara, Vandendries Erik, Fujii Yosuke, Hino Masayuki

    International Journal of Hematology   110 ( 6 )   709 - 722   2019.12( ISSN:0925-5710

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    再発性/難治性B細胞急性リンパ芽球性白血病(ALL)のアジア人患者におけるイノツズマブオゾガマイシン(InO)と標準治療(SoC)の有効性および安全性を評価するため、INO-VATE試験のサブグループ解析を実施した。INO-VATE試験では、アジア人患者55例をInO群31例(男性13例、中央値42.0歳)とSoC群24例(男性16例、中央値36.5歳)に無作為に割り付けた。完全寛解(CR)または不完全な血液学的回復を伴うCR(CRi)はInO群の31例中22例、SoC群の24例中5例で達成された。InO群ではCR/CRi達成患者よりも多くの患者が微小残存病変陰性であり、多くの患者が造血幹細胞移植に進んだ。全生存期間中央値はInO群で5.8ヵ月、SoC群で3.9ヵ月であった。類洞閉塞症候群はInO群の5例、SoC群の1例で報告された。以上から、再発性/難治性B細胞ALLのアジア人患者におけるSoCに対するInOの有効性が示され、その有効性および安全性プロファイルは全INO-VATE集団の結果と一致した。

  • 日本人患者に対する一つまたは二つのHLA不一致非血縁ドナーからの同種造血幹細胞移植におけるボルテゾミブを用いた移植片対宿主病予防に関する第1相試験(Phase I study of graft-versus-host disease prophylaxis including bortezomib for allogeneic hematopoietic cell transplantation from unrelated donors with one or two HLA loci mismatches in Japanese patients)

    Nakane Takahiko, Okamura Hiroshi, Tagaito Yumi, Koh Shiro, Yoshimura Takuro, Makuuchi Yosuke, Nanno Satoru, Nakamae Mika, Hirose Asao, Nakashima Yasuhiro, Koh Hideo, Hino Masayuki, Nakamae Hirohisa

    International Journal of Hematology   110 ( 6 )   736 - 742   2019.12( ISSN:0925-5710

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    日本におけるHLA不一致非血縁ドナーからの同種造血幹細胞移植(HCT)におけるボルテゾミブによる移植片対宿主病(GVHD)予防の安全性を調べるため、第1相試験を実施した。2012年10月~2018年10月に6例(年齢38~64歳)が試験に参加した。6例に対しボルテゾミブ1.3mg/m2が投与され、用量制限毒性が発生した場合に用量を調節した。初回投与に参加した6例のうち5例が骨髄ドナーであった。全例が好中球生着と完全ドナーキメラ化を達成した。3例がグレードIIの急性GVHDを呈した。第100日までにグレードIII-IVのGVHDまたはボルテゾミブ起因性の用量制限毒性は認めなかった。2例に遅発性急性GVHD、2例に慢性GVHDを認めたが、全症例とも管理可能であった。全患者が追跡期間中央値52ヵ月に再発なく生存した。ボルテゾミブの至適用量は1.3mg/m2であると決定された。HLA不一致非血縁同種HCTに対するボルテゾミブを含むレジメンを用いたGVHD予防は実施可能であると考えられた。

  • Impact of Donor KIR and HLA Genotypes on Clinical Outcomes According to Pre-Transplant Remission Status after HLA-Haploidentical Transplantation with Post-Transplantation Cyclophosphamide Reviewed

    Ido Kentaro, Koh Hideo, Okamura Hiroshi, Koh Shiro, Nanno Satoru, Nishimoto Mitsutaka, Hirose Asao, Nakamae Mika, Nakashima Yasuhiro, Nakane Takahiko, Hino Masayuki, Nakamae Hirohisa

    BLOOD   134   2019.11( ISSN:0006-4971

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1182/blood-2019-125173

  • Pretransplant Risk Factors for Calcineurin Inhibitor-Induced Encephalopathy and Limbic Encephalitis Following Allogeneic Hematopoietic Cell Transplantation Reviewed

    Tanizawa Nao, Koh Hideo, Okamura Hiroshi, Shiro Koh, Nanno Satoru, Nishimoto Mitsutaka, Hirose Asao, Nakamae Mika, Nakashima Yasuhiro, Nakane Takahiko, Hino Masayuki, Nakamae Hirohisa

    BLOOD   134   2019.11( ISSN:0006-4971

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1182/blood-2019-124264

  • Phase 2 Study of Bosutinib in Japanese Patients with Newly Diagnosed Chronic Phase Chronic Myeloid Leukemia Reviewed

    Takahashi Naoto, Matsumura Itaru, Fujisawa Shin, Ishizawa Kenichi, Ono Takaaki, Sakaida Emiko, Sekiguchi Naohiro, Tanetsugu Yusuke, Fukuhara Kei, Ohkura Masayuki, Koide Yuichiro, Hino Masayuki

    BLOOD   134   2019.11( ISSN:0006-4971

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1182/blood-2019-121809

  • The Proportional Relationship Between Pretransplant WT1 mRNA Levels and Risk of Mortality After Allogeneic Hematopoietic Cell Transplantation in Acute Myeloid Leukemia Not in Remission. Reviewed

    Ido K, Nakamae M, Koh H, Okamura H, Nanno S, Nishimoto M, Takeoka Y, Hirose A, Nakashima Y, Hashimoto Y, Nakane T, Hino M, Nakamae H

    Transplantation   103 ( 10 )   2201 - 2210   2019.10( ISSN:0041-1337

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    同種造血幹細胞移植を受け、WT1の値が得られた急性骨髄性白血病患者を対象として、予後を後方視的に解析した。非寛解例において、WT1 5,000 copies/μg RNA以上であることが死亡リスクを増加させた(HR 2.7、p = 0. 008)。WT1上昇に伴って死亡に対するハザード比が単調増加していることがわかった。WT1は腫瘍量の把握や移植前の治療の目標値として有用である可能性がある。

    DOI: 10.1097/TP.0000000000002662

    PubMed

  • Clinical Impacts of Using Serum IL-6 Level as an Indicator of Cytokine Release Syndrome after HLA-Haploidentical Transplantation with Post-Transplantation Cyclophosphamide Reviewed International coauthorship

    Nishimoto Mitsutaka, Hirose Asao, Koh Hideo, Nakamae Mika, Nanno Satoru, Okamura Hiroshi, Nakane Takahiko, Nakashima Yasuhiro, Hino Masayuki, Nakamae Hirohisa

    BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION   25 ( 10 )   2061 - 2069   2019.10( ISSN:1083-8791

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    移植後大量シクロフォスファミドを用いたHLA半合致同種造血幹細胞移植時にサイトカイン放出症候群がしばしば観察されるが、移植後治療成績との関連は十分に調べられていない。本論文では炎症性サイトカインである血清IL-6がサイトカイン放出症候群の重症度を反映し、移植直後の血清IL-6高値が移植後非再発死亡の上昇および生存率悪化との関連があることを報告している。

    DOI: 10.1016/j.bbmt.2019.06.003

    PubMed

  • Association Between Vertebral Fracture and Diffuse Idiopathic Skeletal Hyperostosis. Reviewed

    Murakami Y, Mashima N, Morino T, Fukuda T, Iwase M, Hino M, Misaki H, Miura H

    Spine   44 ( 18 )   E1068 - E1074   2019.09( ISSN:0362-2436

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1097/BRS.0000000000003151

    PubMed

  • Short-Term Fasting Induces Cell Cycle Arrest in Immature Hematopoietic Cells and Increases the Number of Naïve T Cells in the Bone Marrow of Mice Reviewed International coauthorship

    Takakuwa T, Nakashima Y, Koh H, Nakane T, Nakamae H, Hino M

    Acta Haematol   141 ( 3 )   189 - 198   2019.06

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  • Successful treatment of invasive pulmonary aspergillosis caused by Aspergillus felis, a cryptic species within the Aspergillus section Fumigati: A case report Reviewed

    Yamairi Kazushi, Ido Kentaro, Nakamura Shigeki, Niki Makoto, Imoto Waki, Shibata Wataru, Namikawa Hiroki, Fujimoto Hiroki, Yamada Koichi, Nakamae Hirohisa, Hino Masayuki, Kaneko Yukihiro, Miyazaki Yoshitsugu, Kakeya Hiroshi

    Journal of Infection and Chemotherapy   25 ( 3-4 )   307 - 310   2019.04( ISSN:1341-321X

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    Publishing type:Research paper (scientific journal)  

    41歳の骨髄異形成症候群の女性が自家末梢血幹細胞移植を受けてから19日後に発熱し、気管支肺胞洗浄液から真菌のβ-チューブリン遺伝子をPCRで増幅し、Aspergillus felisを同定し、エキノキャンディンが奏功した。

  • Aspergillus section Fumigati内の潜在種Aspergillus felisに起因する侵襲性肺アスペルギローシスの治療の成功 症例報告(Successful treatment of invasive pulmonary aspergillosis caused by Aspergillus felis, a cryptic species within the Aspergillus section Fumigati: A case report)

    Yamairi Kazushi, Ido Kentaro, Nakamura Shigeki, Niki Makoto, Imoto Waki, Shibata Wataru, Namikawa Hiroki, Fujimoto Hiroki, Yamada Koichi, Nakamae Hirohisa, Hino Masayuki, Kaneko Yukihiro, Miyazaki Yoshitsugu, Kakeya Hiroshi

    Journal of Infection and Chemotherapy   25 ( 3-4 )   307 - 310   2019.04( ISSN:1341-321X

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    41歳女。骨髄異形成症候群と診断されていた。自己末梢血幹細胞移植の施行19日後に発熱し、侵襲性肺アスペルギローシスと診断しボリコナゾール(VRCZ)による治療を開始した。確定診断のため、気管支鏡検査と気管支肺胞洗浄を行った。治療開始1ヵ月後でも患者の肺病変は変化なく、発熱も持続したため、抗菌薬をアンホテリシンBリポソーム製剤に切り替えたところ、副作用の嘔気が出現した。VRCZとカスポファンギン(CPFG)による併用療法を開始した結果、肺病変のサイズが徐々に減少した。気管支肺胞洗浄液から単離した糸状菌のβ-チューブリン遺伝子を、PCR産物からプライマー対を用いて直接配列決定し、Aspergillus felisとの100%の類似性を確認した。次いで実施した感受性試験の結果を基に、抗菌薬をVRCZ+CPFGからミカファンギンに変えると、5ヵ月間で治療が奏効した。

  • Calcium Channel Blockers Possibly Delay the Elimination of Plasma Methotrexate in Patients Receiving High-Dose Methotrexate Therapy Reviewed

    Inose R, Takahashi K, Nanno S, Hino M, Nagayama K

    J Chemother   103 ( 10 )   2201 - 2210   2019.02

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  • Refractory ascites caused by lymphatic flow disorder after stem cell transplantation for acute myeloid leukemia Reviewed

    60 ( 1 )   12 - 16   2019.01( ISSN:0485-1439

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  • Short-Term Fasting Induces Cell Cycle Arrest in Immature Hematopoietic Cells and Increases the Number of Naive T Cells in the Bone Marrow of Mice Reviewed International coauthorship

    Takakuwa Teruhito, Nakashima Yasuhiro, Koh Hideo, Nakane Takahiko, Nakamae Hirohisa, Hino Masayuki

    ACTA HAEMATOLOGICA   141 ( 3 )   189 - 198   2019( ISSN:0001-5792

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    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

    DOI: 10.1159/000496096

    PubMed

  • Rituximabが有効であったHLA半合致移植後の脊髄長大病変を伴う再発性急性散在性脳脊髄炎 Reviewed

    幕内 陽介, 西本 光孝, 山本 圭一, 高橋 利幸, 久野 雅智, 中嶋 康博, 康 秀男, 中根 孝彦, 日野 雅之, 中前 博久

    臨床血液   59 ( 12 )   2588 - 2593   2018.12( ISSN:0485-1439

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    急性混合性白血病に対して移植後大量シクロフォスファミドを用いたHLA半合致同種末梢血幹細胞移植を行い、慢性GVHDに起因した脊髄長大病変を伴う再発性の急性散在性脳脊髄炎(acute disseminated encephalomyelitis、ADEM)を合併した1症例を経験した。ステロイド治療に抵抗性を認めたがrituximabの投与が有効であった。

  • Long-Term Efficacy and Safety (5 Years) in RESPONSE, a Phase 3 Study Comparing Ruxolitinib (rux) with Best Available Therapy (BAT) in Hydroxyurea (HU)-Resistant/Intolerant Patients (pts) with Polycythemia Vera (PV) Reviewed

    Kiladjian Jean-Jacques, Zachee Pierre, Hino Masayuki, Pane Fabrizio, Masszi Tamas, Harrison Claire N., Mesa Ruben A., Miller Carole B., Passamonti Francesco, Durrant Simon, Griesshammer Martin, Kirito Keita, Besses Carles, Moiraghi Beatriz, Rumi Elisa, Rosti Vittorio, Blau Igor W., Francillard Nathalie, Dong Tuochuan, Wroclawska Monika, Vannucchi Alessandro M., Verstovsek Srdan

    BLOOD   132   2018.11( ISSN:0006-4971

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1182/blood-2018-99-115129

  • The Proportional Association between WT1 mRNA Level in Peripheral Blood before Allogeneic Hematopoietic Cell Transplantation and Risk of Mortality in Acute Myeloid Leukemia Not in Remission Reviewed

    Ido Kentaro, Nakamae Mika, Koh Hideo, Okamura Hiroshi, Nanno Satoru, Nishimoto Mitsutaka, Hashimoto Yoshinori, Takeoka Yasunobu, Hirose Asao, Nakashima Yasuhiro, Nakane Takahiko, Hino Masayuki, Nakamae Hirohisa

    BLOOD   132   2018.11( ISSN:0006-4971

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1182/blood-2018-99-111834

  • 産科大量出血2症例における2社のFDP・D-ダイマー及びその比と線溶分子マーカーの推移について Reviewed

    藤井 一貴, 中前 美佳, 今井 重良, 久保田 浩, 藤岡 一也, 上田 香織, 小宮山 豊, 内田 啓子, 三杉 卓也, 古山 将康, 日野 雅之

    日本検査血液学会雑誌   19 ( 3 )   328 - 334   2018.11( ISSN:1347-2836

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    産科大量出血2症例の経過において、産科DICスコアの検査項目、DD/FDP比、線溶分子マーカーの推移を検討した。大量出血時に症例1ではPT、Fbg以外の項目、症例2では全ての項目が異常値を示し、止血が得られると値が正常値に回復した。リアスオートでのDD/FDP比は分子マーカーの推移と連動するような動きを示し、病勢をより鋭敏に反映する可能性が示唆された。

  • A multi-center prospective study randomizing the use of fat emulsion in intensive glucose control after allogeneic hematopoietic stem cell transplantation using a myeloablative conditioning regimen. Reviewed

    Fuji S, Kim SW, Kamiya S, Nakane T, Matsumoto K, Onishi Y, Yakushijin K, Yamazaki E, Hino M, Kurosawa S, Yoshimura KI, Fukuda T

    Clinical nutrition   37 ( 5 )   1534 - 1540   2018.10( ISSN:0261-5614

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    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

    同種移植患者の栄養管理における脂肪乳剤の有用性を検討した。100日での感染症累積発生率は、無脂肪乳剤群で16%、脂肪乳剤群で19%で差を認めなかった。4年後の全生存率と非再発死亡率は、無脂肪乳剤群で75%と11%、脂肪乳剤群で69%と8%であった。

    DOI: 10.1016/j.clnu.2017.08.022

    PubMed

  • Diagnostic value of serum ferritin and cytokine profiles of hemophagocytic syndrome following allogeneic hematopoietic cell transplantation: methodological issues Reviewed

    Koh Hideo, Nanno Satoru, Hino Masayuki, Nakamae Hirohisa

    LEUKEMIA & LYMPHOMA   59 ( 3 )   772 - 773   2018.10( ISSN:1042-8194

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    同種造血細胞移植受けた患者223人中18人の患者が血球貪食症候群(HPS)を発症し、30,000µg/Lを超える血清フェリチンレベルがHPS診断特異性が高かった。HPSの発症時にはTh1サイトカイン(IFN-γ)、Th2サイトカイン(IL-10)、ケモカイン(MCP-1およびIP-10)が有意に上昇していた。

    DOI: 10.1080/10428194.2017.1361033

    PubMed

  • Validation of previous prognostic models for thrombosis and exploration of modified models in patients with essential thrombocythemia. Reviewed

    Hashimoto Y, Nakamae H, Tanaka T, Omura H, Horiuchi M, Yoshimura T, Takakuwa T, Mugitani A, Hirose A, Nakamae M, Koh H, Hino M

    European journal of haematology   101 ( 4 )   508 - 513   2018.10( ISSN:0902-4441

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    日本人の本態性血小板血症(ET)患者352人を対象に予後因子を検討した。国際予後スコア(IPSET)、従来のリスク分類、血栓症の国際予後スコア(IPSET-T)は、日本人患者でも再現性があったが、改訂版IPSET-Tでは低リスクカテゴリと中リスクカテゴリの間に有意差は認められなかったため、修正を行ったところ、修正IPSET-Tは、治療レジメンに関係なく、治療的介入を必要とする集団を層別化することが可能であった。

    DOI: 10.1111/ejh.13136

    PubMed

  • KMFに登録されたボルテゾミブとIMiDs両剤に抵抗性の再発骨髄腫の予後解析 Reviewed

    藤原亮介, 田中宏和, 芹澤憲太郎, 金子仁臣, 志村勇司, 太田健介, 淵田真一, 中谷 綾, 諫田淳也, 八木秀男, 和田勝也, 小杉智, 魚嶋伸彦, 柴山浩彦, 小原尚恵, 中谷英仁, 内山人二, 足立陽子, 飯田正人, 濱田常義, 松田光弘, 高折晃史, 野村昌作, 島崎千尋, 日野雅之, 黒田純也, 谷脇雅史, 今田和典, 金倉譲, 松村到

    第80回日本血液学会学術集会   2018.10

  • 形質細胞腫の後方視的多施設共同研究(関西骨髄腫フォーラム) Reviewed

    中谷 綾, 田中宏和, 八木秀男, 太田健介, 柴山浩彦, 諫田淳也, 新堂真紀, 志村勇司, 小杉 智, 木田 亨, 金子仁臣, 今田和典, 烏野隆博, 松田光弘, 飯田正人, 足立陽子, 淵田真一, 魚嶋伸彦, 内山人二, 高橋良一, 松井利充, 和田勝也, 清田実希, 島崎 千尋, 日野雅之, 黒田純也, 金倉 譲, 高折晃史, 野村昌作, 松村到

    第80回日本血液学会学術集会   2018.10

  • サリドマイド単剤治療を施行した症候性骨髄腫230例の後方視的解析(関西骨髄腫フォーラム) Reviewed

    金子仁臣, 柴山浩彦, 八木秀男, 諫田淳也, 中谷 綾, 小杉 智, 木田 亨, 田中宏和, 志村勇司, 淵田真一, 足立陽子, 和田勝也, 清田実希, 魚嶋伸彦, 太田健介, 小原尚恵, 濱田常義, 小林正行, 内山人二, 烏野隆博, 黒田純也, 今田和典, 高折晃史, 島崎千尋, 金倉 譲, 日野雅之, 野村昌作, 松村 到

    第80回日本血液学会学術集会   2018.10

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    Publishing type:Research paper (other academic)  

  • Risk Factors for Delirium after Spine Surgery: An Age-Matched Analysis. Reviewed

    Morino T, Hino M, Yamaoka S, Misaki H, Ogata T, Imai H, Miura H

    Asian spine journal   12 ( 4 )   703 - 709   2018.08( ISSN:1976-1902

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    DOI: 10.31616/asj.2018.12.4.703

    PubMed

  • Retrospective analysis of primary plasma cell leukemia in Kansai Myeloma Forum registry. Reviewed

    Nakaya A, Yagi H, Kaneko H, Kosugi S, Kida T, Adachi Y, Shibayama H, Kohara T, Kamitsuji Y, Fuchida SI, Uoshima N, Kawata E, Uchiyama H, Shimura Y, Takahashi T, Urase F, Ohta K, Hamada T, Miyamoto K, Kobayashi M, Shindo M, Tanaka H, Shimazaki C, Hino M, Kuroda J, Kanakura Y, Takaoari-Kondo A, Nomura S, Matsumura I, Kansai Myeloma Forum Investigators.

    Leukemia research reports   10 ( 10 )   7 - 10   2018.07

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    原発性形質細胞白血病(pPCL)患者26人を後方視的に解析した。20人の患者がボルテゾミブまたはレナリドマイドで治療され、生存期間中央値は34ヶ月であった。自家幹細胞移植(SCT)を受けた患者の生存期間中央値は40ヶ月、同種SCTを受けた患者は55ヶ月、両方のSCTを受けた患者は61ヶ月であった。一方、SCTを受けなかった場合は28ヶ月であった。多変量解析では高カルシウム血症が有意な危険因子であった。

    DOI: 10.1016/j.lrr.2018.07.001

    PubMed

  • Prophylactic Combined Use of Anticoagulant Agent and Ursodeoxycholic Acid for Sinusoidal Obstruction Syndrome after Allogeneic Myeloablative Hematopoietic Stem Cell Transplantation Reviewed

    Okamura Hiroshi, Koh Hideo, Nishimoto Mitsutaka, Nakane Takahiko, Nakashima Yasuhiro, Nakamae Mika, Hirose Asao, Hino Masayuki, Nakamae Hirohisa

    Osaka City Medical Journal   64 ( 1 )   43 - 54   2018.06( ISSN:0030-6096

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    骨髄破壊的前処置による同種造血幹細胞移植(HSCT)を受けた患者において、類洞閉塞症候群(SOS)の予防目的で行った凝固薬とウルソデオキシコール酸(UDCA)の併用投与の有効性を後ろ向きに評価した。SOS発症率、移植後30日または100日以内の出血イベントの発症率に有意差を認めなかった。

  • 同種造血幹細胞移植後の類洞閉塞症候群予防を目的とした抗凝固薬とウルソデオキシコール酸の併用投与(Prophylactic Combined Use of Anticoagulant Agent and Ursodeoxycholic Acid for Sinusoidal Obstruction Syndrome after Allogeneic Myeloablative Hematopoietic Stem Cell Transplantation)

    Okamura Hiroshi, Koh Hideo, Nishimoto Mitsutaka, Nakane Takahiko, Nakashima Yasuhiro, Nakamae Mika, Hirose Asao, Hino Masayuki, Nakamae Hirohisa

    Osaka City Medical Journal   64 ( 1 )   43 - 54   2018.06( ISSN:0030-6096

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    当施設で骨髄破壊的前処置による同種造血幹細胞移植(HSCT)を受けた患者において、類洞閉塞症候群(SOS)の予防目的で行った凝固薬とウルソデオキシコール酸(UDCA)の併用投与の有効性を後ろ向きに評価した。2000年6月~2014年5月にHSCT後のSOS予防のためUDCAとダルテパリンまたはダナパロイドのいずれかが併用投与された患者(I群)59例とUDCA単剤を投与された患者(II群)193例を対象とした。Seattle基準、Baltimore基準によるそれぞれのSOS発症率、および移植後30日、100日以内の出血イベント発症率を検討した。I群の59例中9例(15.3%)とII群の193例中28例(14.5%)がSOSを発症した。SOS発症率に関して両群間に有意差は認めなかった。移植後30日または100日以内の出血イベントの発症率においても、両群間で有意差を認めなかった。以上から、HSCT後のSOS予防にUDCAを使用する場合、抗凝固薬を併用投与することの意義は乏しいと考えられた。

  • Final 3-year Results of the Dasatinib Discontinuation Trial in Patients With Chronic Myeloid Leukemia Who Received Dasatinib as a Second-line Treatment Reviewed

    Okada Masaya, Imagawa Jun, Tanaka Hideo, Nakamae Hirohisa, Hino Masayuki, Murai Kazunori, Ishida Yoji, Kumagai Takashi, Sato Seiichi, Ohashi Kazuteru, Sakamaki Hisashi, Wakita Hisashi, Uoshima Nobuhiko, Nakagawa Yasunori, Minami Yosuke, Ogasawara Masahiro, Takeoka Tomoharu, Akasaka Hiroshi, Utsumi Takahiko, Uike Naokuni, Sato Tsutomu, Ando Sachiko, Usuki Kensuke, Mizuta Syuichi, Hashino Satoshi, Nomura Tetsuhiko, Shikami Masato, Fukutani Hisashi, Ohe Yokiko, Kosugi Hiroshi, Shibayama Hirohiko, Maeda Yasuhiro, Fukushima Toshihiro, Yamazaki Hirohito, Tsubaki Kazuo, Kukita Toshimasa, Adachi Yoko, Nataduka Toshiki, Sakoda Hiroto, Yokoyama Hisayuki, Okamoto Takahiro, Shirasugi Yukari, Onishi Yasushi, Nohgawa Masaharu, Yoshihara Satoshi, Morita Satoshi, Sakamoto Junichi, Kimura Shinya

    CLINICAL LYMPHOMA MYELOMA & LEUKEMIA   18 ( 5 )   353 - 360   2018.05( ISSN:2152-2650

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    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

    二次治療としてダサチニブで加療を受けた慢性骨髄性白血病患者でダサチニブ中止し、無治療寛解(TFR)を検討する試験(DADI)において予測因子を分析した。36ヶ月での推定TFR率は44.4%で、分子再発を発症した患者はわずか2人であった。イマチニブ耐性の存在は、分子再発の重大な危険因子で、中止前のナチュラルキラー細胞活性の高値、γδ+ T細胞およびCD4 +調節性T細胞(CD25 + CD127low)の数の低値は、治療中止の成功と有意に相関していた。

    DOI: 10.1016/j.clml.2018.03.004

    PubMed

  • イマチニブで分子遺伝学的大奏効となったCML-CP患者におけるニロチニブ切り替えの有効性と安全性 多施設共同第II相試験(NILSw試験)の結果 Reviewed

    107 ( 5 )   535 - 540   2018.05( ISSN:0925-5710

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  • 日本にける再発性/難治性多発性骨髄腫に対するポマリドミド単独またはポマリドミド+デキサメタゾン併用投与 関西骨髄腫フォーラムによる後向き解析 Reviewed

    107 ( 5 )   541 - 550   2018.05( ISSN:0925-5710

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  • 混合表現型急性白血病、B/myeloid型、非特異型で構成された非白血病性の肉腫の初めての症例 Reviewed

    57 ( 8 )   1155 - 1158   2018.04( ISSN:0918-2918

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  • 日本における非血縁ドナーからの末梢血幹細胞移植を受けた51例の前向き観察研究 Reviewed

    107 ( 2 )   211 - 221   2018.02( ISSN:0925-5710

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    DOI: 10.1007/s12185-017-2341-y

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  • 脾腫を伴うヒドロキシ尿素抵抗性または不耐性の日本人真性赤血球増加症患者に対するルキソリチニブの有効性と安全性 Reviewed International coauthorship

    107 ( 2 )   173 - 184   2018.02( ISSN:0925-5710

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    DOI: 10.1007/s12185-017-2333-y

    PubMed

  • 脾腫を伴うヒドロキシ尿素抵抗性または不耐性の日本人真性赤血球増加症患者に対するルキソリチニブの有効性と安全性(Ruxolitinib is effective and safe in Japanese patients with hydroxyurea-resistant or hydroxyurea-intolerant polycythemia vera with splenomegaly)

    Kirito Keita, Suzuki Kenshi, Miyamura Koichi, Takeuchi Masahiro, Handa Hiroshi, Okamoto Shinichiro, Gadbaw Brian, Yamauchi Kyosuke, Amagasaki Taro, Ito Kazuo, Hino Masayuki

    International Journal of Hematology   107 ( 2 )   173 - 184   2018.02( ISSN:0925-5710

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    脾腫を伴うヒドロキシ尿素抵抗性または不耐性の真性赤血球増加症患者に対するルキソリチニブの有効性と安全性について検討するため実施した、無作為化非盲検多施設共同第III相試験のサブグループ解析を報告する。無作為に割り付けられた患者のうち、日本人患者18例(ルキソリチニブ投与群6例(男性3例、女性3例、中央値62.0歳)、Best Available Therapy(BAT)施行群12例(男性4例、女性8例、中央値60.0歳))について検討した。ルキソリチニブは10mg、1日2回投与、BATはヒドロキシ尿素、IFN/ペグIFN、アナグレリド、ピポブロマン、免疫調節薬を選択し、最大80週投与した。複合一次エンドポイントは32週後のヘマトクリット値コントロールと脾臓反応とした。検討の結果、複合エンドポイントからみた奏効率はルキソリチニブ群が50.0%、BAT群が8.3%であり、ルキソリチニブ群の方が有意に高値であった。脾臓反応が得られたのはルキソリチニブ群が50.0%、BAT群が8.3%、ヘマトクリット値のコントロールを達成したのはルキソリチニブ群が100%、BAT群が33.3%、血液学的完全寛解を認めたのはルキソリチニブ群が33.3%、BAT群が16.7%であった。また、有害事象の発現率はルキソリチニブ群の方がBAT群より低値であり、血液学的有害事象は主に低グレードであった。日本人の真性赤血球増加症患者に対して、ルキソリチニブは有効かつ安全であることが示された。

  • 日本における非血縁ドナーからの末梢血幹細胞移植を受けた51例の前向き観察研究(Prospective observational study on the first 51 cases of peripheral blood stem cell transplantation from unrelated donors in Japan)

    Goto Tatsunori, Tanaka Takashi, Sawa Masashi, Ueda Yasunori, Ago Hiroatsu, Chiba Shigeru, Kanamori Heiwa, Nishikawa Akinori, Nougawa Masaharu, Ohashi Kazuteru, Okumura Hirokazu, Tanimoto Mitsune, Fukuda Takahiro, Kawashima Naomi, Kato Tomonori, Okada Kazuya, Nagafuji Koji, Okamoto Shin-ichiro, Atsuta Yoshiko, Hino Masayuki, Tanaka Junji, Miyamura Koichi

    International Journal of Hematology   107 ( 2 )   211 - 221   2018.02( ISSN:0925-5710

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    非血縁ドナーからの末梢血幹細胞移植(URPBSCT)を受けた血液悪性疾患患者51例(男性40例、女性11例、中央値50歳)を対象に、その実施可能性を前向き観察研究によって検討した。移植前処置として31例に骨髄破壊的処置、20例に減量強度処置を行い、GVHD予防目的にタクロリムスを全例に投与した。検討の結果、移植後28日目における累積好中球生着率は96%、移植後60日目の累積血小板生着率は78%であった。急性GVHDの発症を24例(47%)に認め、移植後100日目の累積発症率はグレードII~IVが25%、グレードIII~IVが10%であった。移植後100日目における生存例44例のうち、慢性GVHDの発症は25例(57%)であり、1年累積発症率は52%、2年累積発症率は57%を示していた。また、16例(31%)が中央値161日後に再燃をきたし、1年累積再燃率は35%、2年累積再燃率は40%であった。移植後の死亡は27例(53%)であり、死因は再燃が最も多く15例、以下、急性GVHD2例、感染症2例、出血2例の順であった。非再燃死亡率は100日目が12%、移植1年後が14%を示していた。生存可能性は移植後100日目が86%、1年後が59%、2年後が44%であった。URPBSCTの施行に際しては、慢性GVHDの発症を最小化させるような対応が必要と考えられた。

  • 慢性期の慢性骨髄性白血病患者に対する二次療法としての低用量ダサチニブ投与の有効性 関東CML研究グループのLD-CML研究 Reviewed

    57 ( 1 )   17 - 23   2018.01( ISSN:0918-2918

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  • The First Case of Non-leukemic Sarcoma Composed of Mixed-phenotype Acute Leukemia, B/myeloid, Not Otherwise Specified Reviewed

    Takakuwa Teruhito, Nakane Takahiko, Ohsawa Masahiko, Nagasaki Joji, Aoyama Yasutaka, Nishimoto Mistutaka, Hayashi Yoshiki, Kuwae Yuko, Hino Masayuki, Nakamae Hirohisa

    一般社団法人 日本内科学会 INTERNAL MEDICINE   57 ( 8 )   1155 - 1158   2018( ISSN:0918-2918

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    <p>Isolated sarcoma with features of mixed-phenotype acute leukemia (MPAL) is an extremely rare disease and it can be easily misdiagnosed as lymphoma or other malignancies. We herein report the case of a 61-year-old woman with non-leukemic sarcoma of the right pleura, pretracheal lymph node, and supraclavicular lymph node with features of MPAL, B/myeloid, not otherwise specified, which was first misdiagnosed as diffuse large B cell lymphoma. After performing a detailed re-examination of the biopsy specimens, few scattered eosinophilic myelocytes allowed us to reach a correct diagnosis of MPAL and the patient was thereafter successfully treated by intensified chemotherapy followed by cord blood transplantation. </p>

    DOI: 10.2169/internalmedicine.9144-17

    CiNii Article

  • Successful treatment with rituximab in acute disseminated encephalomyelitis with whole spinal cord involvement following HLA haploidentical transplantation

    MAKUUCHI Yosuke, NISHIMOTO Mitsutaka, YAMAMOTO Keiichi, TAKAHASHI Toshiyuki, KUNO Masatomo, NAKASHIMA Yasuhiro, KOH Hideo, NAKANE Takahiko, HINO Masayuki, NAKAMAE Hirohisa

    Rinsho Ketsueki   59 ( 12 )   2588 - 2593   2018( ISSN:0485-1439

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    <p>Chronic graft versus host disease (cGVHD) of the central nervous system is a rare condition that could occur after allogeneic hematopoietic stem cell transplantation (SCT) but has been poorly documented. Here, we report a patient diagnosed with recurrent acute disseminated encephalomyelitis (ADEM) with longitudinal extensive transverse myelitis (LETM) as cGVHD after HLA haploidentical peripheral blood SCT using posttransplantation cyclophosphamide for mixed-phenotype acute leukemia. We observed clinical and radiological improvement after the rituximab treatment of the condition that had been refractory to steroids. To the best of our knowledge, no report of cGVHD presented recurrent ADEM with LETM after allogeneic SCT and successfully treated with rituximab. Hence, ADEM should be included in the differential diagnosis of neurological symptoms in posttransplant patients with cGVHD.</p>

    DOI: 10.11406/rinketsu.59.2588

    PubMed

    CiNii Article

  • A nationwide survey of hypoplastic myelodysplastic syndrome (a multicenter retrospective study) Reviewed

    Kobayashi Takashi, Nannya Yasuhito, Ichikawa Motoshi, Oritani Kenji, Kanakura Yuzuru, Tomita Akihiro, Kiyoi Hitoshi, Kobune Masayoshi, Kato Junji, Kawabata Hiroshi, Shindo Motohiro, Torimoto Yoshihiro, Yonemura Yuji, Hanaoka Nobuyoshi, Nakakuma Hideki, Hasegawa Daisuke, Manabe Atsushi, Fujishima Naohito, Fujii Nobuharu, Tanimoto Mitsune, Morita Yasuyoshi, Matsuda Akira, Fujieda Atsushi, Katayama Naoyuki, Ohashi Haruhiko, Nagai Hirokazu, Terada Yoshiki, Hino Masayuki, Sato Ken, Obara Naoshi, Chiba Shigeru, Usuki Kensuke, Ohta Masatsugu, Imataki Osamu, Uemura Makiko, Takaku Tomoiku, Komatsu Norio, Kitanaka Akira, Shimoda Kazuya, Watanabe Kenichiro, Tohyama Kaoru, Takaori-Kondo Akifumi, Harigae Hideo, Arai Shunya, Miyazaki Yasushi, Ozawa Keiya, Kurokawa Mineo

    AMERICAN JOURNAL OF HEMATOLOGY   92 ( 12 )   1324 - 1332   2017.12( ISSN:0361-8609

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    低形成性骨髄異形成症候群(hMDS:129人)は非hMDS(115人)と比較してFAB分類ではRAが多く、CMMoLとRAEB-tが少なく、WHO分類ではRCUDとMDS-Uが多く、RCMDが少なかった。hMDS患者の全生存率およびAMLに進行しない生存率は、特に50歳以上IPSS-R低リスクで、非hMDS患者より高かった。

    DOI: 10.1002/ajh.24905

    PubMed

  • The activated conformation of integrin β7 is a novel multiple myeloma-specific target for CAR T cell therapy Reviewed

    Hosen Naoki, Matsunaga Yukiko, Hasegawa Kana, Matsuno Hiroshi, Nakamura Yuki, Makita Mio, Watanabe Kouki, Yoshida Mikako, Satoh Kei, Morimoto Soyoko, Fujiki Fumihiro, Nakajima Hiroko, Nakata Jun, Nishida Sumiyuki, Tsuboi Akihiro, Oka Yoshihiro, Manabe Masahiro, Ichihara Hiroyoshi, Aoyama Yasutaka, Mugitani Atsuko, Nakao Takafumi, Hino Masayuki, Uchibori Ryosuke, Ozawa Keiya, Baba Yoshihiro, Terakura Seitaro, Wada Naoki, Morii Eiichi, Nishimura Junichi, Takeda Kiyoshi, Oji Yusuke, Sugiyama Haruo, Takagi Junichi, Kumanogoh Atsushi

    NATURE MEDICINE   23 ( 12 )   1436 - 1443   2017.12( ISSN:1078-8956

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    10,000以上の抗多発性骨髄腫モノクローナル抗体(MM mAb)クローンをスクリーニングし、MMG49をインテグリンβ7分子のサブセットを特異的に認識するMM特異的mAbとして同定した。MMG49由来キメラ抗原受容体(CAR)を導入したT細胞は、正常な造血細胞を損傷することなく抗MM効果を発揮した。

    DOI: 10.1038/nm.4431

    PubMed

  • Prior harvesting and cryopreservation of peripheral blood stem cells from related donors: current situations in Japan Reviewed

    KOBAYASHI Takeshi, OHASHI Kazuteru, HARAGUCHI Kyoko, OKUYAMA Yoshiki, HINO Masayuki, TANAKA Junji, UEDA Yasunori, NISHIDA Tetsuya, ATSUTA Yoshiko, TAKANASHI Minoko, IIDA Minako, MUROI Kazuo, YABE Hiromasa, MIYAMURA Koichi

    The Japanese Society of Hematology, Rinsho Ketsueki   58 ( 11 )   2205 - 2212   2017.11( ISSN:0485-1439

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    Although peripheral blood stem cell (PBSC) transplantations in an unrelated transplant setting have been performed since 2010, prior harvesting and cryopreservation of PBSCs from unrelated donors has not been approved in Japan. There are no restrictions with regard to related donors. Therefore, in April 2015, we conducted a nationwide survey and obtained written answers from 123 transplant hospitals throughout Japan. Our survey revealed that as much as 81.3% of transplant hospitals routinely perform prior harvesting and cryopreservation of PBSCs from related donors and that both cell processing and quality management of cryopreserved products have been appropriately conducted in line with domestic guidelines, although post-thaw quality control and storage period setting require further improvements. Moreover, informed consent obtained from both patients and donors with regard to cryopreservation of PBSCs was not always sufficient in some hospitals. We found that the average number of unused or discarded cryopreserved PBSCs is 1.09 per hospital, and the overall nonuse or discard rates of cryopreserved PBSCs were estimated to be as low as 2.67%.</p>

    DOI: 10.11406/rinketsu.58.2205

    PubMed

    CiNii Article

  • 同種造血細胞移植前自律神経機能の異常は、移植後後生存に対する強力な予測因子である Reviewed

    101 ( 11 )   2801 - 2809   2017.11( ISSN:0041-1337

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    DOI: 10.1097/TP.0000000000001813

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  • Diagnostic usefulness of plasma presepsin (soluble CD14-subtype) for diagnosing hemophagocytic syndrome in hematological malignancies Reviewed

    Koh Hideo, Nanno Satoru, Katayama Takako, Hirose Asao, Nakamae Mika, Hino Masayuki, Nakamae Hirohisa

    LEUKEMIA & LYMPHOMA   58 ( 10 )   2489 - 2492   2017.10( ISSN:1042-8194

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    DOI: 10.1080/10428194.2017.1292356

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  • Favorable effects of motivational interviewing and support in a patient with schizophrenia and alcohol abuse. Reviewed

    Makuuchi A, Takemoto Y, Okamura H, Nakane T, Namikawa H, Fukumoto K, Kobayashi M, Kinuhata S, Morimura M, Hirohashi K, Hino M, Shuto T

    Journal of general and family medicine   18 ( 5 )   271 - 274   2017.10( ISSN:2189-6577

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    DOI: 10.1002/jgf2.36

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  • Altered Gene Expression of RNF34 and PACAP Possibly Involved in Mechanism of Exercise-Induced Analgesia for Neuropathic Pain in Rats. Reviewed

    Yamaoka S, Oshima Y, Horiuchi H, Morino T, Hino M, Miura H, Ogata T

    International journal of molecular sciences   18 ( 9 )   2017.09

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    DOI: 10.3390/ijms18091962

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  • Drug interactions and safety profiles with concomitant use of caspofungin and calcineurin inhibitors in allogeneic haematopoietic cell transplantation Reviewed

    Nishimoto Mitsutaka, Koh Hideo, Tokuwame Atsushi, Makuuchi Yosuke, Kuno Masatomo, Takakuwa Teruhito, Okamura Hiroshi, Koh Shiro, Yoshimura Takuro, Nanno Satoru, Nakamae Mika, Hirose Asao, Nakashima Yasuhiro, Nakane Takahiko, Hino Masayuki, Nakamae Hirohisa

    BRITISH JOURNAL OF CLINICAL PHARMACOLOGY   83 ( 9 )   2000 - 2007   2017.09( ISSN:0306-5251

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    同種造血幹細胞移植時における抗真菌薬とカルシニューリン阻害薬における薬剤相互作用は臨床上しばしば問題となるが、カスポファンギンとカルシニューリン阻害薬における薬剤相互作用は十分に調べられていない。本論文では、同種造血幹細胞移植時においてカスポファンギンとタクロリムス、シクロスポリンにおける併用療法は臨床上問題となるような相互作用は認めなかったことを報告している。

    DOI: 10.1111/bcp.13303

    PubMed

  • 高用量メチルプレドニゾロン静注に応答した抗好中球抗体陽性無顆粒球症の高齢女性 Reviewed

    56 ( 16 )   2199 - 2203   2017.08( ISSN:0918-2918

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  • Diagnostic value of serum ferritin and the risk factors and cytokine profiles of hemophagocytic syndrome following allogeneic hematopoietic cell transplantation Reviewed

    Nanno Satoru, Koh Hideo, Nakashima Yasuhiro, Katayama Takako, Okamura Hiroshi, Koh Shiro, Yoshimura Takuro, Nishimoto Mitsutaka, Hayashi Yoshiki, Nakamae Mika, Hirose Asao, Nakane Takahiko, Hino Masayuki, Nakamae Hirohisa

    LEUKEMIA & LYMPHOMA   58 ( 7 )   1664 - 1672   2017.07( ISSN:1042-8194

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    DOI: 10.1080/10428194.2016.1262034

    PubMed

  • Clinicopathologic significance of the CXCL1-CXCR2 axis in the tumor microenvironment of gastric carcinoma Reviewed

    Kasashima Hiroaki, Yashiro Masakazu, Nakamae Hirohisa, Masuda Go, Kinoshita Haruhito, Morisaki Tamami, Fukuoka Tatsunari, Hasegawa Tsuyoshi, Nakane Takahiko, Hino Masayuki, Hirakawa Kosei, Ohira Masaichi

    PLOS ONE   12 ( 6 )   e0178635   2017.06( ISSN:1932-6203

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    癌細胞におけるCXCL1の発現は、がん深達度(T2-T4)、リンパ節転移、リンパ菅浸潤、静脈浸潤、腹膜転移、腹膜転移および間質細胞におけるCXCR2発現と相関していた。間質細胞におけるCXCR2の発現は、肉眼的IV型癌、組織型、がん深達度(T2-T4)、リンパ節転移、リンパ菅浸潤、腹膜転移および間質細胞におけるCD271発現と相関があった。 CXCL1およびCXCR2陽性がん患者の全生存率は陰性がん患者よりも低かった。

    DOI: 10.1371/journal.pone.0178635

    PubMed

  • Immunoprofile Changes during Dasatinib Treatment in Patients with Chronic Myeloid Leukemia: A Prospective Observational Study Reviewed

    Kuno Masatomo, Nakane Takahiko, Katayama Takako, Koh Hideo, Nakashima Yasuhiro, Nishimoto Mitsutaka, Nakamae Mika, Hirose Asao, Hino Masayuki, Nakamae Hirohisa

    Osaka City Medical Journal   63 ( 1 )   43 - 55   2017.06( ISSN:0030-6096

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    一次または二次治療以降にTKI投与した30人の慢性期CML患者において、ダサチニブでLGL数,NK細胞数,NK活性が有意に増加していた。NK活性とTreg数はそれぞれBCR-ABL mRNA量と有意に相関した。他のTKIで有意な免疫細胞の変化はなかった。ダサチニブ開始前と開始3か月後、開始前と開始6か月後のT-LGL数が有意な正の相関を示した。ダサチニブで増加したNK活性は抗CML効果を有し、治療前に存在するT-LGL数が予後に影響する可能性が示唆された。

  • HLA適合血縁者および非血縁ボランティアドナーからの同種造血幹細胞移植におけるミコフェノール酸モフェチルおよびカルシニューリン阻害剤の使用 日本における多施設第II相試験 Reviewed

    105 ( 4 )   485 - 496   2017.04( ISSN:0925-5710

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  • Pericarditis Associated With Human Herpesvirus-6 Reactivation in a Patient After Unrelated Cord Blood Transplant Reviewed

    Yoshida Masahiro, Nakamae Hirohisa, Okamura Hiroshi, Nishimoto Mitsutaka, Hayashi Yoshiki, Koh Hideo, Nakane Takahiko, Hino Masayuki

    EXPERIMENTAL AND CLINICAL TRANSPLANTATION   15 ( 2 )   235 - 238   2017.04( ISSN:1304-0855

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    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work   International / domestic magazine:International journal  

    症例は53歳女性。骨髄異形成症候群に対して、骨髄破壊的前処置を用いた臍帯血移植を行った。移植前の心機能に異常を認めなかったが、移植後第11日目に心嚢液貯留を伴う急性心不全を発症し、利尿剤や血管拡張剤、強心薬の使用で改善を認めた。移植後第28日目に著明な心嚢液貯留を認め、心外膜炎と診断した。心嚢ドレナージにて心嚢液を採取した。細菌・真菌は認めなかったが、HHV-6を30000copy/ml認めた。心嚢液は保存的加療で改善を認めたが、HHV-6再活性化が本例の心外膜炎発症に関与していると考えられた。

    DOI: 10.6002/ect.2014.0261

    PubMed

  • 日本骨髄バンクドナーの2回骨髄提供に関する検討 Reviewed

    折原 勝己, 吾郷 浩厚, 奥山 美樹, 落合 亮一, 澤 正史, 田野崎 隆二, 玉井 佳子, 豊嶋 崇徳, 中尾 康夫, 日野 雅之, 宮崎 泰司, 神田 善伸, 金森 平和

    (一社)日本造血細胞移植学会 日本造血細胞移植学会雑誌   6 ( 2 )   108 - 114   2017.04

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    日本骨髄バンクを介して2回の骨髄提供を行ったドナーの身体的負担および移植への影響を解析した。解析対象ドナーは820人で、1回目提供から2回目提供までの間隔は約4年であった。コーディネート期間は1回目に比べて2回目は明らかに短縮されていた。また、骨髄穿刺部の痛みの程度は変わりなかったが、痛みの持続日数および日常生活への復帰日数は1回目より2回目で短かった。骨髄採取時間、骨髄採取量、総細胞数、細胞濃度、細胞数/患者体重の1回目:2回目の平均値は、74分:78分(P<0.001)、821mL:848mL(P=0.095)、160×10^8個:139×10^8個(P<0.001)、2.0×10^7個/mL:1.7×10^7個/mL(P<0.001)、3.0×10^8個/kg:2.7×10^8個/kg(P<0.001)であった。2回目提供の骨髄移植では造血回復の遅延がみられ、標準リスクの患者群では生存率の低下がみられた。これらの結果から、2回目提供ドナーへの身体的負担は長期的な影響は不明だが、許容範囲と考えられた。また、移植結果への影響については、さらに詳細な解析が必要である。(著者抄録)

  • HLA適合血縁者および非血縁ボランティアドナーからの同種造血幹細胞移植におけるミコフェノール酸モフェチルおよびカルシニューリン阻害剤の使用 日本における多施設第II相試験(Use of mycophenolate mofetil and a calcineurin inhibitor in allogeneic hematopoietic stem-cell transplantation from HLA-matched siblings or unrelated volunteer donors: Japanese multicenter phase II trials)

    Nakane Takahiko, Nakamae Hirohisa, Yamaguchi Takuhiro, Kurosawa Saiko, Okamura Atsuo, Hidaka Michihiro, Fuji Shigeo, Kohno Akio, Saito Takeshi, Aoyama Yasutaka, Hatanaka Kazuo, Katayama Yoshio, Yakushijin Kimikazu, Matsui Toshimitsu, Yamamori Motohiro, Takami Akiyoshi, Hino Masayuki, Fukuda Takahiro

    International Journal of Hematology   105 ( 4 )   485 - 496   2017.04( ISSN:0925-5710

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    HLA適合血縁ドナー(MRD)および非血縁ドナー(HRD)からの同種造血幹細胞移植(HSCT)を実施し、移植片対宿主病(GVHD)予防におけるミコフェノール酸モフェチル(MMF)とカルシニューリン阻害剤(CNI)の実施可能性、ならびにミコフェノール酸(MPA)レベルとGVHDとの関連を調べる2つの多施設前向き第II相試験を実施した。対象はMRD群20例(男性8例、女性12例、年齢中央値47歳、MMFおよびシクロスポリン)、URD群31例(男性17例、女性14例、年齢中央値45歳、MMFおよびタクロリムス)とした。第100日における急性GVHDグレードII~IVの累積発現率は、MRD群で45.0%、URD群で25.8%であった。3年生存率はMRD群で80.0%、URD群で74.2%であった。非再発死亡率はMRD群で15.0%、URD群で6.5%であった。MMFによるGVHD予防は、メトトレキサートと比較して重症粘膜炎の発現頻度が低く、好中球生着が迅速であった。薬物動態試験では、MPA血漿濃度高値と急性GVHD発現頻度低値との間に関連が認められた。

  • Cidofovir Treatment for Adenovirus-Associated Hemorrhagic Cystitis in Adult Recipients of Allogeneic Hematopoietic Stem Cell Transplantation: A Retrospective Comparative Study Reviewed

    Yoshimura Takuro, Nishimoto Mitsutaka, Nakane Takahiko, Koh Hideo, Nakashima Yasuhiro, Takeoka Yasunobu, Nakamae Mika, Hirose Asao, Hino Masayuki, Nakamae Hirohisa

    BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION   23 ( 3 )   S191 - S191   2017.03( ISSN:1083-8791

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  • Dasatinib and Prednisolone Induction Therapy for a Case of Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia with Dilated Cardiomyopathy Accompanied by Life-Threatening Ventricular Tachycardia Reviewed

    Nishimoto Mitsutaka, Nakamae Hirohisa, Matsumoto Kana, Morita Kunihiko, Koga Yuki, Momose Dai, Hino Masayuki

    CASE REPORTS IN HEMATOLOGY   2017   4027908   2017( ISSN:2090-6560

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    症例は56歳男性。拡張型心筋症の治療中にフィラデルフィア染色体陽性急性リンパ性白血病を発症した。致死的不整脈である断続的心室頻拍を併発しており、抗不整脈薬であるアミオダロン併用のもとQT延長の副作用のある第2世代チロシンキナーゼ阻害剤であるダサチニブとプレドニゾロンで寛解導入療法を行なった。アミオダロン、ダサチニブの両薬剤血中濃度と臨床経過中の心毒性関連合併症との関係について考察している。

    DOI: 10.1155/2017/4027908

    PubMed

  • An Elderly Woman with Anti-neutrophil Antibody-positive Agranulocytosis Who Responded to High-dose Intravenous Methylprednisolone Reviewed

    Shiro Koh, Hideo Koh, Yuki Kubo, Maiko Kuroda, Mitsutaka Nishimoto, Takuro Yoshimura, Yasuhiro Nakashima, Takahiko Nakane, Hirohisa Nakamae, Masahiko Ohsawa, Masayuki Hino

    JAPAN SOC INTERNAL MEDICINE INTERNAL MEDICINE   56 ( 16 )   2199 - 2203   2017( ISSN:0918-2918

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    Although anti-neutrophil antibodies (ANAs) often exist and immunoreaction may be involved in agranulocytosis, few reports have so far described ANA-positive cases of agranulocytosis with an unknown etiology. We herein describe the case of a 69-year-old woman who presented with ANA-positive agranulocytosis. In this case, both the withdrawal of the drugs that had possibly caused neutropenia and the use of granulocytecolony stimulating factor (G-CSF) were ineffective treatment measures. Approximately 2 weeks after the discontinuation of the suspected drugs, we initiated corticosteroid pulse therapy; the neutrophil count recovered by day 19 of steroid therapy. High-dose methylprednisolone therapy should thus be considered for patients demonstrating ANA-positive agranulocytosis with an unknown etiology that is refractory to G-CSF treatment.

    DOI: 10.2169/internalmedicine.8268-16

  • Wilms Tumor 1 (WT1) mRNA Expression Level at Diagnosis Is a Significant Prognostic Marker in Elderly Patients with Myelodysplastic Syndrome Reviewed

    Nagasaki Joji, Aoyama Yasutaka, Hino Masayuki, Ido Kentaro, Ichihara Hiroyoshi, Manabe Masahiro, Ohta Tadanobu, Mugitani Atsuko

    ACTA HAEMATOLOGICA   137 ( 1 )   32 - 39   2017( ISSN:0001-5792

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    WT1mRNA発現レベルはAML患者の予後予測因子となることが報告されているが、MDS患者での有用性は明らかではない。我々は42名の高齢MDS患者の臨床データを用いて、WT1mRNA発現レベルと予後との関連性、および既存の予後因子であるWPSSおよびIPSS-Rとの関連性について後方視的に解析を行った。high-risk MDS患者群でWT1mRNA発現レベルは有意に高かった。また、患者のOSおよびPFSはWT1mRNA高発現患者群で有意に低下していた。

    DOI: 10.1159/000452732

    PubMed

  • Combination of Frailty Status and Comorbidity Score Improves the Prediction of Survival in Patients with Myelodysplastic Syndrome Due to Good Predictive Capability for Infection-Related Mortality Reviewed

    Sakatoku Kazuki, Takeoka Yasunobu, Araki Taku, Yamamura Ryosuke, Nakane Takahiko, Nakamae Hirohisa, Hino Masayuki, Ohta Kensuke

    BLOOD   128 ( 22 )   2016.12( ISSN:0006-4971

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  • Switching to nilotinib in patients with chronic myeloid leukemia in chronic phase with molecular suboptimal response to frontline imatinib: SENSOR final results and BIM polymorphism substudy Reviewed

    Miyamura Koichi, Miyamoto Toshihiro, Tanimoto Mitsune, Yamamoto Kazuhito, Kimura Shinya, Kawaguchi Tatsuya, Matsumura Itaru, Hata Tomoko, Tsurumi Hisashi, Saito Shigeki, Hino Masayuki, Tadokoro Seiji, Meguro Kuniaki, Hyodo Hideo, Yamamoto Masahide, Kubo Kohmei, Tsukada Junichi, Kondo Midori, Aoki Makoto, Okada Hikaru, Yanada Masamitsu, Ohyashiki Kazuma, Taniwaki Masafumi

    LEUKEMIA RESEARCH   51   11 - 18   2016.12( ISSN:0145-2126

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    イマチニブ投与でMMRが得られていない慢性骨髄性白血病患者を対象にニロチニブに変更した結果、12ヶ月および24ヶ月で51.1%、66.7%のMMRを達成した。チロシンキナーゼ阻害薬の反応に影響すると報告されているBIM多型を伴う12人中10人(83.3%)および28人中17人(60.7%)が24ヶ月でMMRを達成した。ニロチニブは、イマチニブに対する反応が十分えない患者にも有効で、BIM多型はMMRの達成に影響しなかった。

    DOI: 10.1016/j.leukres.2016.09.009

    PubMed

  • CXCL1-Chemokine (C-X-C Motif) Receptor 2 Signaling Stimulates the Recruitment of Bone Marrow-Derived Mesenchymal Cells into Diffuse-Type Gastric Cancer Stroma Reviewed

    Kasashima Hiroaki, Yashiro Masakazu, Nakamae Hirohisa, Kitayama Kisyu, Masuda Go, Kinoshita Haruhito, Fukuoka Tatsunari, Hasegawa Tsuyoshi, Nakane Takahiko, Hino Masayuki, Hirakawa Kosei, Ohira Masaichi

    AMERICAN JOURNAL OF PATHOLOGY   186 ( 11 )   3028 - 3039   2016.11( ISSN:0002-9440

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    DOI: 10.1016/j.ajpath.2016.07.024

    PubMed

  • 発熱を伴う好中球減少症患者の細菌同定に対する23SリボソームRNA遺伝子を標的とするin situハイブリダイゼーションと血液培養との組み合わせアプローチ Reviewed

    22 ( 9-10 )   697 - 703   2016.10( ISSN:1341-321X

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  • The authors' comments on the editorial by Specht.

    Yoshida M, Koh H, Nakane T, Hino M, Yamane T

    European journal of haematology   97 ( 4 )   406   2016.10( ISSN:0902-4441

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  • Disseminated Hormographiella aspergillata infection with involvement of the lung, brain, and small intestine following allogeneic hematopoietic stem cell transplantation: case report and literature review Reviewed

    Nanno S., Nakane T., Okamura H., Nishimoto M., Koh H., Nakamae H., Ohsawa M., Yarita K., Kamei K., Hino M.

    TRANSPLANT INFECTIOUS DISEASE   18 ( 4 )   611 - 616   2016.08( ISSN:1398-2273

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    DOI: 10.1111/tid.12561

  • Prognostic Effect of Low Subcutaneous Adipose Tissue on Survival Outcome in Patients With Multiple Myeloma Reviewed

    Takeoka Yasunobu, Sakatoku Kazuki, Miura Akiko, Yamamura Ryosuke, Araki Taku, Seura Hirotaka, Okamura Terue, Koh Hideo, Nakamae Hirohisa, Hino Masayuki, Ohta Kensuke

    CLINICAL LYMPHOMA MYELOMA & LEUKEMIA   16 ( 8 )   434 - 441   2016.08( ISSN:2152-2650

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    DOI: 10.1016/j.clml.2016.04.010

    PubMed

  • 慢性移植片対宿主病に関連する多発性筋炎におけるTh1、Th2、Th17サイトカインの血漿中動態 Reviewed

    55 ( 16 )   2265 - 2270   2016.08( ISSN:0918-2918

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  • 血液悪性腫瘍における血球貪食症候群の新規予後予測マーカーとしての血漿プレセプシン(可溶性CD14サブタイプ Reviewed

    55 ( 16 )   2173 - 2184   2016.08( ISSN:0918-2918

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  • 血液疾患患者の発熱性好中球減少症におけるプレセプシン(可溶性CD14サブタイプ)レベルの診断的価値 Reviewed

    22 ( 7-8 )   466 - 471   2016.08( ISSN:1341-321X

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  • Ruxolitinib versus best available therapy in patients with polycythemia vera: 80-week follow-up from the RESPONSE trial Reviewed International coauthorship

    Verstovsek Srdan, Vannucchi Alessandro M., Griesshammer Martin, Masszi Tamas, Durrant Simon, Passamonti Francesco, Harrison Claire N., Pane Fabrizio, Zachee Pierre, Kirito Keita, Besses Carlos, Hino Masayuki, Moiraghi Beatriz, Miller Carole B., Cazzola Mario, Rosti Vittorio, Blau Igor, Mesa Ruben, Jones Mark M., Zhen Huiling, Li Jingjin, Francillard Nathalie, Habr Dany, Kiladjian Jean-Jacques

    HAEMATOLOGICA   101 ( 7 )   821 - 829   2016.07( ISSN:0390-6078

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    DOI: 10.3324/haematol.2016.143644

    PubMed

  • 骨髄腫関連疾患における二次癌の検討 関西骨髄腫フォーラムデータベースを用いた解析

    小杉 智, 柴山 浩彦, 中谷 英仁, 木田 亨, 太田 健介, 金子 仁臣, 八木 秀男, 田中 宏和, 淵田 真一, 中谷 綾, 小林 正行, 黒田 純也, 上辻 由里, 魚嶋 伸彦, 足立 陽子, 通堂 満, 島崎 千尋, 野村 昌作, 日野 雅之, 松村 到, 谷脇 雅史, 金倉 譲, 高折 晃史

    臨床血液   57 ( 7 )   839 - 847   2016.07( ISSN:0485-1439

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    新規薬剤により骨髄腫患者の生存が延長すると共に,二次がん発生が問題になっている。今回,関西骨髄腫フォーラム(KMF)データベースを用い,2012年11月〜2015年3月に登録された骨髄腫および関連疾患1571例について二次がん発生を解析した。観察期間(中央値31ヵ月)内に血液腫瘍が10例,固形がんが36例に発生していた(5年累積発生率:血液腫瘍1.0%,固形がん3.7%)。未治療の無症候性骨髄腫およびMGUS症例では,固形がん発生を認める一方で血液腫瘍発生は認めなかったが,累積発生率においては治療例との間に有意差を認めなかった。一方,melphalan,bortezomib,lenalidomideおよびthalidomideの4剤それぞれの投与歴を見た場合,血液腫瘍発生への影響は統計学的に認められない一方,レナリドマイド投与歴のある患者で固形がん発生が多く認められた。より詳細な検討には,本データベースへのさらなる症例数の蓄積と,長期の観察が必要と考える。(著者抄録)

  • Comparison of survival of adolescents and young adults with hematologic malignancies in Osaka, Japan Reviewed

    Nakata-Yamada Kayo, Inoue Masami, Ioka Akiko, Ito Yuri, Tabuchi Takahiro, Miyashiro Isao, Masaie Hiroaki, Ishikawa Jun, Hino Masayuki, Tsukuma Hideaki

    LEUKEMIA & LYMPHOMA   57 ( 6 )   1342 - 1348   2016.06( ISSN:1042-8194

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    DOI: 10.3109/10428194.2015.1083562

    PubMed

  • Lung function score including a parameter of small airway disease as a highly predictive indicator of survival after allogeneic hematopoietic cell transplantation Reviewed

    Nakamae Mika, Yamashita Mariko, Koh Hideo, Nishimoto Mitsutaka, Hayashi Yoshiki, Nakane Takahiko, Nakashima Yasuhiro, Hirose Asao, Hino Masayuki, Nakamae Hirohisa

    TRANSPLANT INTERNATIONAL   29 ( 6 )   707 - 714   2016.06( ISSN:0934-0874

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    末梢気道(V˙50/V˙25)のマーカーを含むPFT指標を、当院で同種移植を受けた206人に対し包括的に移植前に評価した。単変量解析で注目すべきことは、V˙50/V˙25が移植後生存の最も強力な指標だった。さらに、V˙50/V˙25を含む優れた予測値を持つ3つのパラメーターを組み合わせた移植前肺機能スコア(pLFS)は、生存予測曲線を良く分離できた。

    DOI: 10.1111/tri.12779

    PubMed

  • Analysis of elderly patients with diffuse large B-cell lymphoma: aggressive therapy is a reasonable approach for "unfit' patients classified by comprehensive geriatric assessment Reviewed

    Yoshida Masahiro, Nakao Takafumi, Horiuchi Mirei, Ueda Hideya, Hagihara Kiyoyuki, Kanashima Hiroshi, Inoue Takeshi, Sakamoto Erina, Hirai Manabu, Koh Hideo, Nakane Takahiko, Hino Masayuki, Yamane Takahisa

    EUROPEAN JOURNAL OF HAEMATOLOGY   96 ( 4 )   409 - 416   2016.04( ISSN:0902-4441

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    びまん性大細胞型B細胞リンパ腫に罹患した60歳以上の高齢者を、高齢者総合機能評価(CGA)でunfit、fitに分類し、後方視的にCGA分類と予後の関連を解析した。135例が抽出され、治癒を目指した化学療法は85%の症例に施行された。61%が“fit”と分類された。1年全生存率は“fit”症例(91.3%)が”unfit”症例(53.8%)と比べて有意に優れていた。”unfit”と分類された症例のうち治癒的治療を受けた症例(66.1%)は緩和的治療を受けた症例(19.0%)と比較すると有意に生存率が優れていた。

    DOI: 10.1111/ejh.12608

    PubMed

  • Panobinostat PK/PD profile in combination with bortezomib and dexamethasone in patients with relapsed and relapsed/refractory multiple myeloma Reviewed

    Mu Song, Kuroda Yoshiaki, Shibayama Hirohiko, Hino Masayuki, Tajima Takeshi, Corrado Claudia, Lin Rong, Waldron Edward, Binlich Florence, Suzuki Kenshi

    EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY   72 ( 2 )   153 - 161   2016.02( ISSN:0031-6970

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    DOI: 10.1007/s00228-015-1967-z

    PubMed

  • Plasma Kinetics of Th1, Th2 and Th17 Cytokines in Polymyositis Related to Chronic Graft-versus-Host Disease Reviewed

    Shiro Koh, Hideo Koh, Yasuhiro Nakashima, Takako Katayama, Manami Sakabe, Hiroshi Okamura, Takuro Yoshimura, Satoru Nanno, Mitsutaka Nishimoto, Yoshiki Hayashi, Takahiko Nakane, Hirohisa Nakamae, Masahiko Ohsawa, Masayuki Hino

    JAPAN SOC INTERNAL MEDICINE INTERNAL MEDICINE   55 ( 16 )   2265 - 2270   2016( ISSN:0918-2918

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    We herein describe a case of myelodysplastic syndrome with chronic graft-versus-host disease (cGVHD)-related polymyositis. On approximately day 1,570 post HLA-identical sibling bone marrow transplant, the patient presented with a fever, myalgia and liver dysfunction. A muscle biopsy revealed destruction of the muscle fibers and infiltration of CD20(+) B cells and CD4(+) and CD8(+) T cells, and a liver biopsy confirmed the findings of cGVHD. An analysis of plasma cytokine profiles indicated elevation of not only T-helper (Th) 1 and Th2, but also Th17 cytokines. Increases in these cytokines in addition to the invasion of inflammatory cells might be associated with the pathophysiology of cGVHD involving the muscle and liver.

    DOI: 10.2169/internalmedicine.55.6206

  • Plasma Levels of Presepsin (Soluble CD14-subtype) as a Novel Prognostic Marker for Hemophagocytic Syndrome in Hematological Malignancies Reviewed

    Satoru Nanno, Hideo Koh, Takako Katayama, Masamichi Hashiba, Ayumi Sato, Yosuke Makuuchi, Joji Nagasaki, Masatomo Kuno, Takuro Yoshimura, Hiroshi Okamura, Mitsutaka Nishimoto, Asao Hirose, Mika Nakamae, Takahiko Nakane, Masayuki Hino, Hirohisa Nakamae

    JAPAN SOC INTERNAL MEDICINE INTERNAL MEDICINE   55 ( 16 )   2173 - 2184   2016( ISSN:0918-2918

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    Objective Recent studies suggest that presepsin (soluble CD14-subtype) is a useful diagnostic and prognostic marker for sepsis, with secretion by activated macrophages potentially dependent on phagocytosis of microorganisms. As "hemophagocytosis" is one of the major characteristics in patients with hemophagocytic syndrome (HPS), we hypothesized that presepsin may reflect the phagocytic activity and be a useful prognostic marker for HPS. Therefore, we aimed to assess the prognostic potential of presepsin in secondary HPS in adult patients with hematological malignancies.
    Methods Between April 2006 and August 2014, we retrospectively examined consecutive patients with HPS whose blood samples were available at our institution and compared the prognostic value of the following in HPS, singly and in combination: plasma presepsin, serum soluble interleukin (IL)-2 receptor (sIL-2R), ferritin, tumor necrosis factor-alpha (TNF-alpha), interferon-gamma (IFN-gamma), IL-6 and IL-10.
    Results A total of 14 patients were enrolled. The median age of the patients was 46.5 years (range, 22-65). In univariable Cox models, there were no significant variables associated with the prognosis. However, in 12 evaluable patients, only the combination of higher median values of presepsin (&gt; 1,935 pg/mL) and sIL-2R (&gt; 4,585 U/mL) at the onset of HPS was significantly associated with the 90-day mortality (hazard ratio 14.5; 95% CI, 1.47-143.36; p= 0.02).
    Conclusion These results suggest that a composite model of plasma presepsin and serum sIL-2R levels at the onset of HPS might be a novel predictor of the prognosis of patients with hematological malignancies and secondary HPS.

    DOI: 10.2169/internalmedicine.55.6524

  • Second primary malignancies among patients with myeloma-related-diseases in the KMF database Reviewed

    KOSUGI Satoru, SHIBAYAMA Hirohiko, NAKATANI Eiji, KIDA Toru, OHTA Kensuke, KANEKO Hidemi, YAGI Hideo, TANAKA Hirokazu, FUCHIDA Shin-ichi, NAKAYA Aya, KOBAYASHI Masayuki, KURODA Junya, KAMITSUJI Yuri, UOSHIMA Nobuhiko, ADACHI Yoko, TSUDO Mitsuru, SHIMAZAKI Chihiro, NOMURA Shosaku, HINO Masayuki, MATSUMURA Itaru, TANIWAKI Masashi, KANAKURA Yuzuru, TAKAORI-KONDO Akifumi

    Rinsho Ketsueki   57 ( 7 )   839 - 847   2016( ISSN:04851439

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    <p>The incidence of second primary malignancies (SPMs) in Japanese patients with myeloma or myeloma-related diseases was studied by using the Kansai Myeloma Forum (KMF) database registered from November 2012 to March 2015. We studied 1,571 cases. Hematologic malignancies were documented in 10 patients, and solid tumors in 36 during this period. The cumulative 5-year incidence was estimated to be 1.0% for hematological malignancies and 3.7% for solid tumors. In the patients with smoldering myeloma or MGUS without treatment, solid tumors but not hematologic malignancies developed, though the cumulative incidence of each malignancy did not differ significantly from that in patients receiving treatment. Although statistical analysis showed that treatment with melphalan, bortezomib, lenalidomide, or thalidomide had no effect on the occurrence of hematological malignancies, lenalidomide administration was more frequent in the patients with solid tumors. To evaluate the SPMs in myeloma or myeloma-related diseases more accurately, accumulation of a larger number of patients and longer observation are needed.</p>

    DOI: 10.11406/rinketsu.57.839

    PubMed

    CiNii Article

  • Discontinuation of dasatinib in patients with chronic myeloid leukaemia who have maintained deep molecular response for longer than 1 year (DADI trial): a multicentre phase 2 trial Reviewed

    Imagawa Jun, Tanaka Hideo, Okada Masaya, Nakamae Hirohisa, Hino Masayuki, Murai Kazunori, Ishida Yoji, Kumagai Takashi, Sato Seiichi, Ohashi Kazuteru, Sakamaki Hisashi, Wakita Hisashi, Uoshima Nobuhiko, Nakagawa Yasunori, Minami Yosuke, Ogasawara Masahiro, Takeoka Tomoharu, Akasaka Hiroshi, Utsumi Takahiko, Uike Naokuni, Sato Tsutomu, Ando Sachiko, Usuki Kensuke, Morita Satoshi, Sakamoto Junichi, Kimura Shinya

    LANCET HAEMATOLOGY   2 ( 12 )   E528 - E535   2015.12( ISSN:2352-3026

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    DOI: 10.1016/S2352-3026(15)00196-9

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  • Efficacy and safety of intra-arterial steroid infusions in patients with steroid-resistant gastrointestinal acute graft-versus-host disease Reviewed

    Nishimoto Mitsutaka, Koh Hideo, Hirose Asao, Nakamae Mika, Nakane Takahiko, Hayashi Yoshiki, Okamura Hiroshi, Yoshimura Takuro, Koh Shiro, Nanno Satoru, Nakashima Yasuhiro, Takeshita Toru, Yamamoto Akira, Sakai Yukimasa, Nishida Norifumi, Matsuoka Toshiyuki, Miki Yukio, Hino Masayuki, Nakamae Hirohisa

    EXPERIMENTAL HEMATOLOGY   43 ( 12 )   995 - 1000   2015.12( ISSN:0301-472X

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    同種造血幹細胞移植後の急性移植片対宿主病は生命を脅かす重篤な合併症であるが、ステロイド治療に不応であった場合、有効な2次治療は確立されていない。本論文では、ステロイド不応性消化管急性移植片対宿主病に対してステロイド動注療法を2次治療として行ない、過去の自施設データと比較して、非再発死亡を低下させ、生存率の改善が認められ、ステロイド動注療法が有益な2次治療となりうることを報告している。

    DOI: 10.1016/j.exphem.2015.08.002

    PubMed

  • HLA haploidentical peripheral blood stem cell transplantation using reduced dose of posttransplantation cyclophosphamide for poor-prognosis or refractory leukemia and myelodysplastic syndrome Reviewed

    Nakamae Hirohisa, Koh Hideo, Katayama Takako, Nishimoto Mitsutaka, Hayashi Yoshiki, Nakashima Yasuhiro, Nakane Takahiko, Nakamae Mika, Hirose Asao, Hino Masayuki

    EXPERIMENTAL HEMATOLOGY   43 ( 11 )   921 - 929   2015.11( ISSN:0301-472X

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    DOI: 10.1016/j.exphem.2015.07.006

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  • P0344-22-AM 同種造血幹細胞移植におけるカスポファンギンとカルシニューリン阻害剤併用時の薬物相互作用および安全性に関する検討(薬物相互作用,ポスター発表,一般演題,医療薬学の進歩と未来-次の四半世紀に向けて-)

    徳和目 篤史, 西本 光孝, 高橋 正也, 中村 安孝, 康 秀男, 中前 博久, 西川 武司, 日野 雅之, 永山 勝也

    日本医療薬学会年会講演要旨集   25 ( 0 )   323   2015.10

  • Effectiveness of antibacterial prophylaxis with non-absorbable polymyxin B compared to levofloxacin after allogeneic hematopoietic stem cell transplantation Reviewed

    Koh S., Yamada K., Nishimoto M., Hayashi Y., Koh H., Nakashima Y., Nakane T., Hirose A., Nakamae M., Kakeya H., Hino M., Nakamae H.

    TRANSPLANT INFECTIOUS DISEASE   17 ( 5 )   647 - 654   2015.10( ISSN:1398-2273

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    同種造血幹細胞移植時感染予防の非吸収性抗生剤ポリミキシンB(PB)と全身抗生剤レボフロキサシン(LVFX)有効性をPB群106名、LVFX群140名で後方視的に検討した。2群において感染予防失敗の累積発症率、臨床的感染症の発症率、移植後100日までの非再発死亡、全生存率に有意差はなかった.

    DOI: 10.1111/tid.12416

  • Eosinophilic Crisisを呈する骨髄異形成症候群を合併した視神経炎 Reviewed

    54 ( 17 )   2241 - 2244   2015.09( ISSN:0918-2918

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  • Patient-reported quality of life after allogeneic hematopoietic cell transplantation or chemotherapy for acute leukemia Reviewed

    Kurosawa S., Yamaguchi T., Mori T., Kanamori H., Onishi Y., Emi N., Fujisawa S., Kohno A., Nakaseko C., Saito B., Kondo T., Hino M., Nawa Y., Kato S., Hashimoto A., Fukuda T.

    BONE MARROW TRANSPLANTATION   50 ( 9 )   1241 - 1249   2015.09( ISSN:0268-3369

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    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

    DOI: 10.1038/bmt.2015.137

  • Bone marrow-derived stromal cells are associated with gastric cancer progression Reviewed

    Kasashima H., Yashiro M., Nakamae H., Masuda G., Kinoshita H., Morisaki T., Fukuoka T., Hasegawa T., Sakurai K., Toyokawa T., Kubo N., Tanaka H., Muguruma K., Ohira M., Nakane T., Hino M., Hirakawa K.

    BRITISH JOURNAL OF CANCER   113 ( 3 )   443 - 452   2015.07( ISSN:0007-0920

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    DOI: 10.1038/bjc.2015.236

  • 初回治療としてCHOP-R療法を選択した縦隔原発大細胞型B細胞性リンパ腫 Reviewed

    田垣内 優美, 西本 光孝, 林 良樹, 幕内 陽介, 久野 雅智, 高桑 輝人, 岡村 浩史, 吉村 卓朗, 康 史朗, 南野 智, 廣瀬 朝生, 中前 美佳, 中嶋 康博, 康 秀男, 中根 孝彦, 中前 博久, 大澤 政彦, 日野 雅之

    血液診療   11 ( 1 )   16 - 20   2015.07

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    症例は43歳、女性。縦隔原発大細胞型B細胞性リンパ腫(PMBL)、臨床病期IV期と診断した。初回治療としてCHOP-R療法を選択し、経過良好である。PMBLはまれな疾患である。

  • Prospectively Isolated Human Bone Marrow Cell-Derived MSCs Support Primitive Human CD34-Negative Hematopoietic Stem Cells Reviewed

    Matsuoka Yoshikazu, Nakatsuka Ryusuke, Sumide Keisuke, Kawamura Hiroshi, Takahashi Masaya, Fujioka Tatsuya, Uemura Yasushi, Asano Hiroaki, Sasaki Yutaka, Inoue Masami, Ogawa Hiroyasu, Takahashi Takayuki, Hino Masayuki, Sonoda Yoshiaki

    STEM CELLS   33 ( 5 )   1554 - 1565   2015.05( ISSN:1066-5099

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    DOI: 10.1002/stem.1941

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  • 骨髄異形成症候群の同種造血幹細胞移植後再発に合併した冷式自己免疫性溶血性貧血 Reviewed

    岡村 浩史, 中根 孝彦, 藤野 恵三, 康 史郎, 吉村 卓朗, 西本 光孝, 林 良樹, 康 秀男, 中尾 吉孝, 中前 博久, 日野 雅之

    臨床血液   56 ( 4 )   412 - 417   2015.04( ISSN:0485-1439

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    症例は51歳女性。骨髄異形成症候群(MDS)に対して非血縁者間同種骨髄移植を施行したが,その後、再発。入院後貧血に対し連日の赤血球輸血を施行も貧血改善は得られず、精査の結果、冷式自己免疫性溶血性貧血(AIHA)の合併と診断し、加温に加え副腎皮質ホルモン,免疫抑制剤投与,γグロブリン大量静注療法を施行したところ溶血所見の改善が得られた。

  • Prognostic Value and Clinical Implication of Serum Ferritin Levels following Allogeneic Hematopoietic Cell Transplantation Reviewed

    Nakamae Mika, Nakamae Hirohisa, Koh Shiro, Koh Hideo, Nishimoto Mitsutaka, Nakashima Yasuhiro, Nakane Takahiko, Hirose Asao, Hino Masayuki

    ACTA HAEMATOLOGICA   133 ( 3 )   310 - 316   2015.04( ISSN:0001-5792

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    203人の患者に対する同種造血細胞移植後の血清フェリチンの予後評価。 移植後フェリチンは有意に上昇し、75%の患者が移植後90日後にピーク示した。 患者の合計43%で10,000 ng / mlを超えており、これは発熱性好中球減少症または感染症に関連。 移植後30日目および1年後のフェリチンは予後と有意に関連したが、統計的有意差は急性相反応物質の調整後に失われた。

    DOI: 10.1159/000365779

    PubMed

  • Cold autoimmune hemolytic anemia complicated with relapsed myelodysplastic syndrome after allogeneic hematopoietic cell transplantation

    OKAMURA Hiroshi, NAKANE Takahiko, FUJINO Keizo, KOH Shiro, YOSHIMURA Takuro, NISHIMOTO Mitsutaka, HAYASHI Yoshiki, KOH Hideo, NAKAO Yoshitaka, NAKAMAE Hirohisa, HINO Masayuki

    Rinsho Ketsueki   56 ( 4 )   412 - 7   2015.04( ISSN:0485-1439

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    Myelodysplastic syndrome (MDS) is known to often be complicated by a range of autoimmune diseases. We herein present a case with MDS complicated by cold autoimmune hemolytic anemia (cold AIHA). The patient was a 51-year-old woman. She was diagnosed with MDS (refractory cytopenia with multilineage dysplasia) in May 2009. In January 2010, she underwent unrelated allogeneic bone marrow transplantation but was re-admitted in October 2010 for treatment of relapsed MDS. Despite daily transfusions of red blood cells, her anemia failed to improve. Her laboratory examinations showed a low haptoglobin level and elevation of indirect bilirubin and LDH. The direct Coombs test was positive at a low and at room temperature and cold agglutinin was negative. After confirming the diagnosis of cold AIHA, all transfusion fluids were warmed but her anemia still failed to improve. In addition to the warmed transfusion fluids, we administered corticosteroids, immunosuppressive agents and high-dose intravenous immunoglobulin infusions. This management strategy ameliorated the patient's hemolytic anemia. To our knowledge, MDS cases complicated by cold AIHA are rare. Our patient thus provides a valuable contribution to medical knowledge.

    DOI: 10.11406/rinketsu.56.412

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    CiNii Article

  • Response-guided therapy for steroid-refractory acute GVHD starting with very-low-dose antithymocyte globulin Reviewed

    Nishimoto Mitsutaka, Nakamae Hirohisa, Koh Hideo, Nakamae Mika, Hirose Asao, Hayashi Yoshiki, Nakashima Yasuhiro, Nakane Takahiko, Hino Masayuki

    EXPERIMENTAL HEMATOLOGY   43 ( 3 )   177 - 179   2015.03( ISSN:0301-472X

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    同種造血幹細胞移植後の急性移植片対宿主病は生命を脅かす重篤な合併症であるが、ステロイド治療に不応であった場合、有効な治療は確立されていない。本論文では、ステロイド不応性急性移植片対宿主病に対して、抗胸腺細胞グロブリン治療を従来の投与法とは異なる、少量より開始し、治療反応に応じて増減する方法で行なった11例の治療成績について分析し、比較的良好な治療成績を報告している。

    DOI: 10.1016/j.exphem.2014.11.008

    PubMed

  • 発熱性好中球減少症の成人患者における経験的治療としてのセフォゾプラン、メロペネムまたはイミペネム・シラスタチンとセフェピムの比較 多施設前向き無作為化試験 Reviewed

    21 ( 1-2 )   16 - 22   2015.02( ISSN:1341-321X

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  • Therapy-related myelodysplastic syndrome: a case study Reviewed

    Manabe Masahiro, Wada Katsuya, Momose Dai, Sugano Yasuyoshi, Hino Masayuki, Yamane Takahisa, Ishida Eiwa, Koh Ki-Ryang

    American journal of blood research   5 ( 2 )   91 - 94   2015( ISSN:2160-1992

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  • Rectal biopsy, rather than ileal, is appropriate to confirm the diagnosis of early gastrointestinal graft-versus-host disease Reviewed

    Minamino Hiroaki, Machida Hirohisa, Tominaga Kazunari, Morimoto Kenichi, Ominami Masaki, Fukunaga Shusei, Hosomi Shuhei, Hayashi Yoshiki, Nagami Yasuaki, Sugimori Satoshi, Kamata Noriko, Shiba Masatsugu, Nakamae Hirohisa, Yamagami Hirokazu, Tanigawa Tetsuya, Watanabe Toshio, Fujiwara Yasuhiro, Ohsawa Masahiko, Hino Masayuki, Arakawa Tetsuo

    SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY   50 ( 11 )   1428 - 1434   2015( ISSN:0036-5521

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    DOI: 10.3109/00365521.2015.1054421

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  • Optic Neuritis Associated with Myelodysplastic Syndrome Accompanied by Eosinophilic Crisis Reviewed

    Joji Nagasaki, Mitsutaka Nishimoto, Hirohisa Nakamae, Takahiko Nakane, Hideo Koh, Kumiko Yoshimoto, Kunihiko Shiraki, Masayuki Hino

    JAPAN SOC INTERNAL MEDICINE INTERNAL MEDICINE   54 ( 17 )   2241 - 2244   2015( ISSN:0918-2918

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    Myelodysplastic syndrome (MDS) was diagnosed in a 64-year-old man. Three months later, he presented with right-sided visual loss. A diagnosis of optic neuritis caused by both ischemic and non-ischemic changes was established. Concurrently, prominent eosinophilia was seen in both the peripheral blood and bone marrow. A partial improvement of visual loss was obtained concomitant with a rapid decrease of the eosinophils after treatment with corticosteroids. Optic neuritis related to MDS is a rare condition and its etiology has not yet been identified. We herein report a case of optic neuritis associated with MDS and accompanied by an eosinophilic crisis.

    DOI: 10.2169/internalmedicine.54.4148

  • Diagnostic performance of serum high-sensitivity procalcitonin and serum C-reactive protein tests for detecting bacterial infection in febrile neutropenia Reviewed

    Aimoto Mizuki, Koh Hideo, Katayama Takako, Okamura Hiroshi, Yoshimura Takuro, Koh Shiro, Nanno Satoru, Nishimoto Mitsutaka, Hirose Asao, Nakamae Mika, Nakane Takahiko, Nakamae Hirohisa, Kakeya Hiroshi, Hino Masayuki

    INFECTION   42 ( 6 )   971 - 979   2014.12( ISSN:0300-8126

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    発熱性好中球減少症(FN)患者の細菌感染を検出するための血清高感度プロカルシトニン(PCT)とCRPレベルの有用性を前向きに比較した。75例のFNエピソードで評価を行った。ROC曲線下の面積は、PCTで0.824で、CRPでは0.673であった。CRPは感染症の重症度とともに有意に増加する傾向があった。PCTはFN発症後の初期段階での生命にかかわる感染の検出に有用であり、CRP重症度を診断するのに有用である可能性が示唆された。

    DOI: 10.1007/s15010-014-0657-6

    PubMed

  • Prospective long-term study of hepatitis B virus reactivation in patients with hematologic malignancy Reviewed

    Tamori Akihiro, Hino Masayuki, Kawamura Etsushi, Fujii Hideki, Uchida-Kobayashi Sawako, Morikawa Hiroyasu, Nakamae Hirohisa, Enomoto Masaru, Murakami Yoshiki, Kawada Norifumi

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   29 ( 9 )   1715 - 1721   2014.09( ISSN:0815-9319

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    DOI: 10.1111/jgh.12604

    PubMed

  • 当院における臨床分離緑膿菌のカルバペネム系抗菌薬に対する薬剤感受性の比較 Reviewed

    掛屋 弘, 山田 康一, 中家 清隆, 滝沢 恵津子, 岡田 恵代, 藤田 明子, 中村 安孝, 安部 順子, 広瀬 朝生, 金子 幸弘, 日野 雅之

    The Japanese Journal of Antibiotics   67 ( 4 )   241 - 248   2014.08( ISSN:0368-2781

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    臨床分離緑膿菌400株のカルバペネム系抗菌薬に対する薬剤感受性について検討した。感受性株の割合はDRPM 78.3%、MEPM 74.3%、IPM 64.8%であった。耐性菌の割合は、DRPMが12.5%、MEPMが22.8%、IPMが28.5%で、DRPM耐性率はMEPM、IPM耐性率より有意に低かった。MEPM耐性株の7.7%、IPM耐性株の23.7%はDRPMに感受性を示した。IPM耐性株の9.6%はMEPMに感受性であった。MEPMに耐性でIPMに感受性を示す株やDRPMに耐性で、MEPMやIPMに感受性を示す株は一株もなかった。

  • [A comparison of susceptibility of Pseudomonas aeruginosa clinical isolates to carbapenem antibiotics in our hospital]. Reviewed

    Kakeya H, Yamada K, Nakaie K, Takizawa E, Okada Y, Fujita A, Nakamura Y, Abe J, Hirose A, Kaneko Y, Hino M

    The Japanese journal of antibiotics   67 ( 4 )   241 - 248   2014.08( ISSN:0368-2781

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  • Feasibility of umbilical cord blood transplantation with a myeloablative, reduced toxicity-conditioning regimen Reviewed

    Nishimoto M., Nakamae H., Nakamae M., Hirose A., Hagihara K., Koh H., Nakane T., Terada Y., Hino M.

    BONE MARROW TRANSPLANTATION   49 ( 7 )   980 - 981   2014.07( ISSN:0268-3369

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    臍帯血移植は移植源として、ドナーに対する負担がなく、コーディネートに時間がかからないなど他の移植源に比べて優位な面がある一方で、生着不全のリスクが高く、最適な前処置療法は確立されていない。本論文ではフルダラビンを含む骨髄破壊的ではあるが、毒性を減じた前処置療法を用いて臍帯血移植を行った10例の治療成績について分析し、比較的安定した生着率と良好な移植成績を報告している。

    DOI: 10.1038/bmt.2014.60

  • Diffuse large B-cell lymphoma with hemolytic crisis developed twenty years after the onset of Evans syndrome Reviewed

    YOSHIMURA Takuro, NAKANE Takahiko, KAMESAKI Toyomi, INABA Akiko, NISHIMOTO Mitsutaka, MUKAI Satoru, SAKABE Manami, OHSAWA Masahiko, FUJINO Keizo, KOH Hideo, NAKAO Yoshitaka, NAKAMAE Hirohisa, HINO Masayuki

    The Japanese Society of Hematology, Rinsho Ketsueki   55 ( 5 )   546 - 551   2014.05( ISSN:0485-1439

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    A 65-year-old woman was diagnosed with Coombs-positive autoimmune hemolytic anemia (AIHA) and pure red cell aplasia (PRCA) in May 1992. One month later, her PRCA went into remission following treatment but she developed idiopathic thrombocytopenic purpura and was diagnosed with Evans syndrome. Although her condition resolved with administration of prednisolone and azathioprine, it was necessary to continue treatment with gradual tapering over the following two decades. In October 2012, her hemolytic anemia again worsened, and lymph node swelling, splenomegaly and B symptoms developed. She was diagnosed as having diffuse large B-cell lymphoma (DLBCL) based on lymph node biopsy. However, AIHA was not considered to be the cause of her hemolytic anemia, but rather to be related to DLBCL. This was because a Coombs test and other extensive investigations for Coombs negative-AIHA yielded negative results. The patient underwent CHOP therapy, and all of her symptoms improved. Herein, we report this rare case in which DLBCL developed after the onset of Evans syndrome.

    DOI: 10.11406/rinketsu.55.546

    CiNii Article

  • キャリブレーターによる国際標準値変換を可能とするMajor BCR-ABL mRNA測定キットの臨床性能評価 Reviewed

    宮村 耕一, 岡本 真一郎, 薄井 紀子, 日野 雅之, 赤司 浩一, 中世古 知昭, 高橋 直人, 中谷 中, 高橋 啓太, 登 勉, 直江 知樹

    臨床血液   55 ( 5 )   534 - 540   2014.05( ISSN:0485-1439

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    キット内のWHO国際標準品に基づくキャリブレーターを用いて国際標準値(IS)へ変換を行うMajor BCR-ABL mRNA測定キット(M135R)とConversion Factorを用いてISへ変換するHome-brew法との間には良好な相関関係が得られた(r=0.90)。,同一検体を対象に2施設で測定されたM135RのIS間の相関係数は極めて良好であり(r=0.94),ISとして1.0%以下の検体を抽出した解析においても,その関係は維持された。

  • Posterior reversible encephalopathy syndrome following acute pancreatitis during chemotherapy for acute monocytic leukemia Reviewed

    NISHIMOTO Mitsutaka, KOH Hideo, BINGO Masato, YOSHIDA Masahiro, NANNO Satoru, HAYASHI Yoshiki, NAKANE Takahiko, NAKAMAE Hirohisa, SHIMONO Taro, HINO Masayuki

    The Japanese Society of Hematology, Rinsho Ketsueki   55 ( 5 )   552 - 557   2014.05( ISSN:0485-1439

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    We describe an 18-year-old man with acute leukemia who presented with posterior reversible encephalopathy syndrome (PRES) shortly after developing acute pancreatitis. On day 15 after the third consolidation course with high-dose cytarabine, treatment with broad-spectrum antibiotics was initiated for febrile neutropenia. On day 16, he developed septic shock, and subsequently, acute respiratory distress syndrome (ARDS). After adding vancomycin, micafungin and high-dose methylprednisolone (mPSL) to his treatment regimen, these manifestations subsided. On day 22, he received hemodialysis for drug-induced acute renal failure. On day 24, he developed acute pancreatitis possibly due to mPSL; the following day he had generalized seizures, and was intubated. Cerebrospinal fluid findings were normal. Brain MRI revealed hyperintense signals on FLAIR images and increased apparent diffusion coefficient values in the sub-cortical and deep white matter areas of the bilateral temporal and occipital lobes, indicative of vasogenic edema. Thus, we diagnosed PRES. Blood pressure, seizures and volume status were controlled, with MRI findings showing improvement by day 42. He was extubated on day 32 and discharged on day 49 without complications. Although little is known about PRES following acute pancreatitis, clinicians should be aware that this condition may develop.

    DOI: 10.11406/rinketsu.55.552

    CiNii Article

  • [Posterior reversible encephalopathy syndrome following acute pancreatitis during chemotherapy for acute monocytic leukemia].

    Nishimoto M, Koh H, Bingo M, Yoshida M, Nanno S, Hayashi Y, Nakane T, Nakamae H, Shimono T, Hino M

    [Rinsho ketsueki] The Japanese journal of clinical hematology   55 ( 5 )   552 - 7   2014.05( ISSN:0485-1439

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  • [Diffuse large B-cell lymphoma with hemolytic crisis developed twenty years after the onset of Evans syndrome].

    Yoshimura T, Nakane T, Kamesaki T, Inaba A, Nishimoto M, Mukai S, Sakabe M, Ohsawa M, Fujino K, Koh H, Nakao Y, Nakamae H, Hino M

    [Rinsho ketsueki] The Japanese journal of clinical hematology   55 ( 5 )   546 - 51   2014.05( ISSN:0485-1439

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  • Evaluation of clinical performance of the major BCR-ABL mRNA detection kit which enables conversion to international standard scale using the reference material calibrator.

    Miyamura K, Okamoto S, Usui N, Hino M, Akashi K, Nakaseko T, Takahashi N, Nakatani K, Takahashi K, Nobori T, Naoe T

    [Rinsho ketsueki] The Japanese journal of clinical hematology   55 ( 5 )   534 - 40   2014.05( ISSN:0485-1439

  • Cerebral toxoplasmosis after umbilical cord blood transplantation diagnosed by the detection of anti-toxoplasma specific IgM antibody in cerebrospinal fluid Reviewed

    INABA Akiko, KOH Hideo, NAKASHIMA Yasuhiro, NISHIMOTO Mitsutaka, HAYASHI Yoshiki, OKAMURA Hiroshi, INOUE Atsushi, NANNO Satoru, NAKANE Takahiko, SHIMONO Taro, NAKAMAE Hirohisa, HINO Masayuki

    The Japanese Society of Hematology, Rinsho Ketsueki   55 ( 4 )   456 - 460   2014.04( ISSN:0485-1439

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    Cerebral toxoplasmosis is a rare, potentially fatal, complication of hematopoietic cell transplantation. Early definitive diagnosis is very difficult and it may be associated with a poor prognosis. Herein, we describe a 60-year-old woman who developed cerebral toxoplasmosis after cord blood transplantation for myelodysplastic syndrome. During treatment with tacrolimus and methylprednisolone for relapsed grade 2 acute gut GVHD, fever and disturbance of consciousness occurred on day 210. Brain MRI showed multiple ring-enhancing nodular lesions in the thalamus, basal ganglia, brainstem, and subcortical white matter. Cerebrospinal fluid (CSF) assessment revealed elevations of both anti-to-xoplasma IgM and IgG, which were also elevated in serum, but no evidence of other infections or malignancies. Notably, the IgM level was higher in the CSF than in serum. Thus, cerebral toxoplasmosis was diagnosed. Soon after administration of oral sulfamethoxazole/trimethoprim and intravenous clindamycin in combination with short-term dexamethasone for the cerebral edema, her symptoms and signs began to improve. On day 229, both IgM and IgG titers in CSF had clearly decreased but remained essentially constant in serum. She was discharged without clinically significant neurological disorders. This case suggests that CSF specific anti-toxoplasma IgM titers might be useful for early diagnosis of cerebral toxoplasmosis after transplantation.

    DOI: 10.11406/rinketsu.55.456

    CiNii Article

  • 新薬時代における移植不適格と新たに診断された症候性多発性骨髄腫の長期予後を予測するための国際病期分類システムの限定的価値 Reviewed

    99 ( 4 )   441 - 449   2014.04( ISSN:0925-5710

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  • [Cerebral toxoplasmosis after umbilical cord blood transplantation diagnosed by the detection of anti-toxoplasma specific IgM antibody in cerebrospinal fluid].

    Inaba A, Koh H, Nakashima Y, Nishimoto M, Hayashi Y, Okamura H, Inoue A, Nanno S, Nakane T, Shimono T, Nakamae H, Hino M

    [Rinsho ketsueki] The Japanese journal of clinical hematology   55 ( 4 )   456 - 60   2014.04( ISSN:0485-1439

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  • PBSC collection from family donors in Japan: a prospective survey Reviewed International coauthorship

    Kodera Y., Yamamoto K., Harada M., Morishima Y., Dohy H., Asano S., Ikeda Y., Nakahata T., Imamura M., Kawa K., Kato S., Tanimoto M., Kanda Y., Tanosaki R., Shiobara S., Kim S. W., Nagafuji K., Hino M., Miyamura K., Suzuki R., Hamajima N., Fukushima M., Tamakoshi A., Halter J., Schmitz N., Niederwieser D., Gratwohl A.

    BONE MARROW TRANSPLANTATION   49 ( 2 )   195 - 200   2014.02( ISSN:0268-3369

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    DOI: 10.1038/bmt.2013.147

  • Evaluation of clinical performance of the Major <i>BCR-ABL</i> mRNA detection kit which enables conversion to international standard scale using the reference material calibrator

    MIYAMURA Koichi, OKAMOTO Shinichiro, USUI Noriko, HINO Masayuki, AKASHI Koichi, NAKASEKO Tomoaki, TAKAHASHI Naoto, NAKATANI Kaname, TAKAHASHI Keita, NOBORI Tsutomu, NAOE Tomoki

    Rinsho Ketsueki   55 ( 5 )   534 - 540   2014( ISSN:04851439

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    In a multicenter study, we evaluated the Major <i>BCR-ABL</i> mRNA/<i>ABL</i> mRNA quantification kit (M135R), which uses reference material included in the kit designed to report results using the international scale (IS). In total, 127 samples were studied. A good correlation was observed between M135R results and home-brew RT-qPCR results, which are reported on the IS using a conversion factor (r=0.90; n=115). However, the correlation coefficient between M135R results and Amp-CML results was relatively low (r=0.56; n=108). A good correlation was observed between M135R results from the two assay sites (r=0.94; n=115). The subset analysis of samples from the two assay sites showed M135R to have a good correlation even in the low IS range (r=0.98; IS≤1%). M135R showed high sensitivity and accuracy for detecting minimal residual disease and is considered to be a useful tool for treatment response assessment and for early detection of recurrence in CML patients.

    DOI: 10.11406/rinketsu.55.534

    PubMed

    CiNii Article

  • 血液疾患に合併した発熱性好中球減少症患者に対する経験的ボリコナゾール療法 日本の前向き多施設試験 Reviewed

    19 ( 6 )   1126 - 1134   2013.12( ISSN:1341-321X

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  • Retrospective Analysis Of The Recent Treatment Strategies For The Patients With Myeloma-Related Diseases Registered In Kansai Myeloma Forum

    Hirokazu Tanaka, Satoru Kosugi, Toru Kida, Kensuke Ohta, Ryosuke Yamamura, Hirohiko Shibayama, Takae Kohara, Hitomi Kaneko, Shin-ichi Fuchida, Masayuki Kobayashi, Kazue Miyamoto, Maki Shindo, Junya Kuroda, Nobuhiko Uoshima, Yayoi Matsumura, Yumi Yoshii, Yuri Kamitsuji, Shogen Boku, Kazuyoshi Ishii, Mitsuhiro Matsuda, Takayuki Takahashi, Tsuneyoshi Hamada, Yoko Adachi, Eiji Nakatani, Shosaku Nomura, Masafumi Taniwaki, Akifumi Takaori, Chihiro Shimazaki, Mitsuru Tsudo, Masayuki Hino, Itaru Matsumura, Yuzuru Kanakura

    BLOOD   122 ( 21 )   2013.11( ISSN:0006-4971

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  • 急性骨髄性白血病における血小板輸血不応状態は抗血小板第4因子/ヘパリン複合体抗体の吸光度と相関する Reviewed

    98 ( 4 )   472 - 477   2013.10( ISSN:0925-5710

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  • A multicenter clinical study evaluating the confirmed complete molecular response rate in imatinib-treated patients with chronic phase chronic myeloid leukemia by using the international scale of real-time quantitative polymerase chain reaction Reviewed

    Shinohara Yoshinori, Takahashi Naoto, Nishiwaki Kaichi, Hino Masayuki, Kashimura Makoto, Wakita Hisashi, Hatano Yoshiaki, Hirasawa Akira, Nakagawa Yasuaki, Itoh Kuniaki, Masuoka Hidekazu, Aotsuka Nobuyuki, Matsuura Yasuhiro, Takahara Sinobu, Sano Koji, Kuroki Jun, Hata Tomoko, Nakamae Hirohisa, Mugitani Atsuko, Nakane Takahiko, Miyazaki Yasushi, Niioka Takenori, Miura Masatomo, Sawada Kenichi

    HAEMATOLOGICA   98 ( 9 )   1407 - 1413   2013.09( ISSN:0390-6078

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    DOI: 10.3324/haematol.2013.085167

    PubMed

  • Successful Treatment of Both Acute Leukemia and Active Crohn's Disease After Allogeneic Hematopoietic Stem Cell Transplantation Using Reduced-Intensity Conditioning With Fludarabine and Busulfan: A Case Report Reviewed

    Nishimoto M., Nakamae H., Watanabe K., Koh H., Nakane T., Ohsawa M., Arakawa T., Hino M.

    TRANSPLANTATION PROCEEDINGS   45 ( 7 )   2854 - 2857   2013.09( ISSN:0041-1345

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    症例は32歳男性。難治性クローン病の治療中に急性単球性白血病を発症した。化学療法にて寛解に至った後、強度減弱型前処置による同種造血幹細胞移植を施行した。移植後、血液疾患の長期寛解に加えて、難治性クローン病に対しても追加治療なしで寛解を維持した。クローン病の病態を引き起こす免疫系統に対して同種造血幹細胞移植治療が及ぼす影響について考察している。

    DOI: 10.1016/j.transproceed.2013.03.049

  • Clinical Factors Predicting the Response of Acute Graft-versus-Host Disease to Corticosteroid Therapy: An Analysis from the GVHD Working Group of the Japan Society for Hematopoietic Cell Transplantation Reviewed

    Murata Makoto, Nakasone Hideki, Kanda Junya, Nakane Takahiko, Furukawa Tatsuo, Fukuda Takahiro, Mori Takehiko, Taniguchi Shuichi, Eto Tetsuya, Ohashi Kazuteru, Hino Masayuki, Inoue Masami, Ogawa Hiroyasu, Atsuta Yoshiko, Nagamura-Inoue Tokiko, Yabe Hiromasa, Morishima Yasuo, Sakamaki Hisashi, Suzuki Ritsuro

    BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION   19 ( 8 )   1183 - 1189   2013.08( ISSN:1083-8791

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    DOI: 10.1016/j.bbmt.2013.05.003

    PubMed

  • Maintenance of complete remission after allogeneic stem cell transplantation in leukemia patients treated with Wilms tumor 1 peptide vaccine Reviewed

    Maeda T., Hosen N., Fukushima K., Tsuboi A., Morimoto S., Matsui T., Sata H., Fujita J., Hasegawa K., Nishida S., Nakata J., Nakae Y., Takashima S., Nakajima H., Fujiki F., Tatsumi N., Kondo T., Hino M., Oji Y., Oka Y., Kanakura Y., Kumanogoh A., Sugiyama H.

    BLOOD CANCER JOURNAL   3 ( 8 )   e130   2013.08( ISSN:2044-5385

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    DOI: 10.1038/bcj.2013.29

  • Angioimmunoblastic T cell lymphoma complicated with endocapillary proliferative glomerulonephritis Reviewed

    NANNO Satoru, MAKAMAE Hirohisa, KUWAMURA Yukinobu, ISHIMURA Eiji, SAKABE Manami, INABA Akiko, KOH Shiro, YOSHIMURA Takuro, NISHIMOTO Mitsutaka, HAYASHI Yoshiki, TERADA Yoshiki, NAKANE Takahiko, KOH Hideo, NAKAO Yoshitaka, OHSAWA Masahiko, HINO Masayuki

    The Japanese Society of Hematology, Rinsho Ketsueki   54 ( 7 )   658 - 663   2013.07( ISSN:04851439

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    A 30-year-old female developed fever and multiple lymphadenopathy in September 2011. Her symptoms improved with antibiotic treatment. However, she again presented with fever and multiple lymphadenopathy in December 2011. In addition, she suffered from nephrotic syndrome with severe edema. She was therefore hospitalized to undergo detailed examinations. Renal biopsy revealed endocapillary proliferative glomerulonephritis. Since her renal function deteriorated rapidly, she was given steroid pulse therapy with methylprednisolone, followed by maintenance therapy with prednisolone. After treatment, her renal function improved but multiple lymphadenopathy persisted. Biopsy of a left axillary lymph node was then performed and revealed angioimmunoblastic T-cell lymphoma (AITL). She received CHOP therapy but showed no response. Therefore, she was given ESHAP therapy. A partial response was achieved and the nephrotic syndrome also resolved completely. We report this extremely rare case of renal dysfunction due to endocapillary proliferative glomerulonephritis complicated by AITL.

    DOI: 10.11406/rinketsu.54.658

    CiNii Article

  • Comparison of outcomes between autologous and allogeneic hematopoietic stem cell transplantation for peripheral T-cell lymphomas with central review of pathology Reviewed

    Kim S-W, Yoon S-S, Suzuki R., Matsuno Y., Yi H. G., Yoshida T., Imamura M., Wake A., Miura K., Hino M., Ishikawa T., Kim J. S., Maeda Y., Lee J-J, Kang H. J., Lee H. S., Lee J-H, Izutsu K., Fukuda T., Kim C. W., Yoshino T., Ohshima K., Nakamura S., Nagafuji K., Suzumiya J., Harada M., Kim C. S.

    LEUKEMIA   27 ( 6 )   1394 - 1397   2013.06( ISSN:0887-6924

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    DOI: 10.1038/leu.2012.321

  • チロシンキナーゼ阻害薬で事前治療を受けていたフィラデルフィア染色体陽性急性リンパ芽球性白血病(Ph+ALL)に対する非血縁者からの骨髄移植の予後予測因子と治療成績 Reviewed

    59 ( 1 )   9 - 21   2013.06( ISSN:0030-6096

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  • 消化管急性移植片対宿主病に対するベクロメタゾンプロピオン酸エステル製剤の有効性 Reviewed

    中前 博久, 西本 光孝, 徳和目 篤史, 日野 雅之

    (公財)臨床薬理研究振興財団 臨床薬理の進歩   ( 34 )   93 - 98   2013.06( ISSN:0914-4366

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    消化管急性移植片対宿主病に対するベクロメタゾンプロピオン酸エステル製剤(BDP)の有効性について検討した。同種造血幹細胞移植後に消化管急性GVHDを発症した血液悪性疾患4例を対象とした。4例中、少なくとも2例に完全寛解、部分寛解を認めた。4例中3例は非血縁臍帯血移植症例であった。全身ステロイド投与により感染症が併発あるいは、悪化することを懸念してBDPを投与し、感染症が併発あるいは、悪化した症例は認めなかった。BDP投与の効果を十分認めなった2例のうち1例は、一度、消化管GVHD grade 4まで進展を認め、下部消化管内視鏡での生検でもGVHDが持続していることを確認した。また、1例は、BDPによって一旦、消化管GVHD症状の改善が得られたが、急速なBDPの中止によって消化管GVHD症状の悪化を認め、その後、BDPの漸減を行うことで、消化管GVHDのコントロールが可能になった。

  • Retrospective analysis of eltrombopag for the treatment of refractory primary immune thrombocytopenia in Japan Reviewed

    YOSHIDA Masahiro, KANASHIMA Hiroshi, NAKAO Takafumi, OGAWA Yoshihiko, HINO Masayuki, NAKANE Takahiko, OHTA Tadanobu, KUMURA Takeo, MANABE Masahiro, YAMAMURA Ryosuke, YAMANE Takahisa

    The Japanese Society of Hematology, Rinsho Ketsueki   54 ( 5 )   444 - 450   2013.05( ISSN:04851439

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    Eltrombopag, an oral thrombopoietin receptor agonist, is a novel drug that can be used in cases with previously-treated primary immune thrombocytopenia (ITP). In this study, we retrospectively analyzed 22 Japanese ITP patients treated in four hospitals. A responder was defined as a patient achieving a platelet count between 50,000/μ<i>l</i> and 400,000/μ<i>l</i>, at 75% or more of on-treatment assessments. Excluding 2 patients whose treatments were interrupted at their request, 13 of 20 patients (65%) were responders. Ten of the 13 responders had been taking more than 5 mg of a steroid preparation in the form of prednisolone or its equivalent. In 7 of these patients, the steroid dose could be tapered to 5 mg or less. Disappearance or amelioration of hemorrhagic symptoms was observed in 11 of 19 patients who had these symptoms prior to treatment (9 of 10 responders, 2 of 7 non-responders), and the improvement rate was greater in responders (p=0.018). No factors were identified as being related to efficacy. Reported adverse effects were fever (1), malaise (3), headache (2), and muscle pain (1). One severe adverse event, cerebral thromboembolism, was reported in 1 patient. Although eltrombopag is a useful therapeutic agent for refractory ITP, it is necessary to evaluate its position in the overall treatment strategy for ITP after assessing long-term complications as well as therapeutic effects.

    DOI: 10.11406/rinketsu.54.444

    CiNii Article

  • Two rare cases of extramedullary relapse of acute myeloid leukemia in mammary gland Reviewed

    NAKAMURA Keiko, TAKASHIMA Tsutomu, HINO Masayuki, FUJIOKA Kazuya, TAKEDA Setsuko, OGISAWA Kana, KAWAJIRI Hidemi, ONODA Naoyoshi, ISHIKAWA Tetsuro, HIRAKAWA Kosei

    The Japan Society of Ultrasonics in Medicine, Jpn J Med Ultrasonics   40 ( 3 )   297 - 302   2013.05( ISSN:13461176

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    We encountered two rare cases of extramedullary relapse of acute myeloid leukemia (AML) in mammary gland. [Case 1] A 32-year-old woman who had received intensive chemotherapy for AML achieved complete remission. The AML relapsed 3 years later, at which time allogenic bone marrow transplantation was performed. Six years after initial presentation, a soft tissue mass appeared in the nasal cavity. Biopsy revealed extramedullary relapse of the AML. At the same time, a breast tumor was detected. Ultrasonography showed a lobular-shaped and hypoechogenic tumor in the lower medial quadrant of the left breast. Core needle biopsy showed infiltration of leukemia cells. Although bone marrow biopsy showed no leukemia cells after chemotherapy for AML, the breast tumor remained. A lumpectomy of the breast tumor was performed. The pathological diagnosis of the surgical specimen was invasion of myeloid leukemia in the breast. [Case 2] A 20-year-old man was diagnosed with AML and bilateral gynecomastia. After the patient failed to respond to induction chemotherapy three times, allogeneic bone marrow transplantation was performed, which successfully induced complete remission. The bilateral gynecomastia subsided after remission. Six months after remission, bilateral breast lumps gradually increased in size. Ultrasonography showed hypoechogenic breast tumors with smooth borders under the nipples. Branched blood flow signals were detected in the tumors by color Doppler mode examination. The ultrasonographic findings suggested malignant disorder. Core needle biopsy showed infiltration of leukemia cells in the bilateral breasts. Bone marrow biopsy also showed leukemia cells, prompting a diagnosis of relapsed AML. Extramedullary relapse must be considered when a patient with hematopoietic malignancy develops a breast tumor.

    DOI: 10.3179/jjmu.JJMU.A.1

    CiNii Article

  • Acute myeloid leukemia with monosomy 7 and inv(3) (q21q26.2) complicated with central diabetes insipidus Reviewed

    NANNO Satoru, HAGIHARA Kiyoyuki, SAKABE Manami, OKAMURA Hiroshi, INABA Akiko, NAGATA Yuki, NISHIMOTO Mitsutaka, KOH Hideo, NAKAO Yoshitaka, NAKANE Takahiko, NAKAMAE Hirohisa, SHIMONO Taro, HINO Masayuki

    The Japanese Society of Hematology, Rinsho Ketsueki   54 ( 4 )   397 - 402   2013.04( ISSN:04851439

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    A 20-year-old female presented with thirst, polyposia, and polyuria and was referred to our hospital because of leukocytosis and anemia. Bone marrow aspiration revealed 66.8% myeloperoxidase-positive blasts and trilineage myelodysplasia. The karyotype was 45, XX, inv(3)(q21q26.2), -7[19]. Therefore, a diagnosis of AML with inv(3)(q21q26.2) complicated by -7 was made. Moreover, hyposthenuria and a low anti-diuretic hormone (ADH) level were observed. Although cerebrospinal fluid analysis was normal, magnetic resonance imaging (MRI) revealed the absence of hyperintensity in the neurohypophysis in T1-weighted images. Therefore, she was also diagnosed with diabetes insipidus. After she was administered a desmopressin nasal spray, the volume of urine produced decreased. Following treatment with second induction therapy containing high-dose cytarabine for AML, she achieved complete remission in the bone marrow. Moreover, when the abnormality on MRI and the volume of urine were normalized, she discontinued desmopressin. Although diabetes insipidus is a rare complication of AML, the majority of AML patients who have diabetes insipidus have the abnormal karyotypes with inv(3)(q21q26.2)/t(3;3)(q21;q26.2) and monosomy 7. Further study is required to clarify the pathogenesis and develop a strategy for the treatment of this category of AML.

    DOI: 10.11406/rinketsu.54.397

    CiNii Article

  • 同種骨髄移植後に急性横断性脊髄炎を合併した急性リンパ性白血病 Reviewed

    間部 賢寛, 西本 光孝, 伊藤 和博, 岡村 浩史, 備後 真登, 吉田 全宏, 井上 敦司, 相本 瑞樹, 林 良樹, 康 秀男, 中根 孝彦, 中前 美佳, 寺田 芳樹, 中前 博久, 中尾 隆文, 高 起良, 平井 学, 中尾 吉孝, 山根 孝久, 日野 雅之

    癌と化学療法   40 ( 4 )   529 - 532   2013.04( ISSN:0385-0684

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    症例は40歳、女性。Philadelphia染色体陽性急性リンパ性白血病に対して、非血縁者間骨髄移植を実施した。day 90ごろより知覚異常、膀胱直腸障害および下肢筋力低下を認め、MRI所見も含めて急性横断性脊髄炎と診断した。ステロイドパルスおよび免疫グロブリン製剤投与を行い、症状の改善を得た。

  • Risk factors affecting cardiac left-ventricular hypertrophy and systolic and diastolic function in the chronic phase of allogeneic hematopoietic cell transplantation Reviewed

    Nishimoto M., Nakamae H., Koh H., Nakane T., Nakamae M., Hirose A., Hagihara K., Nakao Y., Terada Y., Ohsawa M., Hino M.

    BONE MARROW TRANSPLANTATION   48 ( 4 )   581 - 586   2013.04( ISSN:0268-3369

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    同種造血幹細胞移植にともなうさまざまな因子が心毒性を引き起こすことが懸念されるが、移植後慢性期における心機能評価についての成人データはほとんどない。本論文では大量放射線療法を含む前処置が移植後慢性期の心収縮能を低下させ、大量シクロフォスファミドを含む骨髄破壊的前処置が移植後慢性期の心拡張能を低下させ、また、移植前血清フェリチン高値が移植後心肥大のリスク因子であることを報告している。

    DOI: 10.1038/bmt.2012.179

  • [Acute transverse myelitis after allogeneic bone marrow transplantation for acute lymphoblastic leukemia--a case report]. Reviewed

    Manabe M, Nishimoto M, Ito K, Okamura H, Bingo M, Yoshida M, Inoue A, Aimoto M, Hayashi Y, Koh H, Nakane T, Nakamae M, Terada Y, Nakamae H, Nakao T, Koh KR, Hirai M, Nakao Y, Yamane T, Hino M

    Gan to kagaku ryoho. Cancer & chemotherapy   40 ( 4 )   529 - 532   2013.04( ISSN:0385-0684

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  • 血液疾患と発熱性好中球減少症の患者に対するセフェピム、パニペネムまたはメロペネム単独療法の前方視的無作為化試験 Reviewed

    19 ( 1 )   103 - 111   2013.02( ISSN:1341-321X

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  • 輸血後鉄過剰症に対する経口鉄キレート剤(deferasirox)の使用経験 Reviewed

    山村亮介、坂本恵利奈、寺田芳樹、阪本親彦、小坂さおり、青山泰孝、平井 学、太田健介、日野雅之

    日本輸血細胞治療学会誌   58   770 - 773   2013

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    輸血後鉄過剰症患者におけるdeferasirox(DFX)による除鉄効果について後方視的に検討した。骨髄異形成症候群や再生不良性貧血など73例について中央値182日(19~428)の観察を行った.血清フェリチン値(SF)は一月あたり平均103ng/ml減少した.目標であるSF<500となり投与が一時終了されたのは3例,それ以外に継続投与が可能であった36例のうちSFが低下したのは19例であった.副作用によりDFXの投与が中止されたのは17例(23.3%)であり消化器症状,腎機能異常が主な原因であった。

  • Dasatinib Maintenance Therapy after Allogeneic Hematopoietic Stem Cell Transplantation for an Isolated Central Nervous System Blast Crisis in Chronic Myelogenous Leukemia Reviewed

    Nishimoto Mitsutaka, Nakamae Hirohisa, Koh Ki-Ryang, Kosaka Saori, Matsumoto Kana, Morita Kunihiko, Koh Hideo, Nakane Takahiko, Ohsawa Masahiko, Hino Masayuki

    ACTA HAEMATOLOGICA   130 ( 2 )   111 - 114   2013( ISSN:0001-5792

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    症例は22歳男性。慢性骨髄性白血病に対する第1世代チロシンキナーゼであるイマチニブにて治療中、末梢血、骨髄では血液学的寛解を維持していたにもかかわらず、中枢神経にて急性転化を起こした。中枢神経への浸透も期待される第2世代チロシンキナーゼであるダサチニブを同種造血幹細胞移植後も投与し、中枢神経の寛解を維持できた。血中および髄液中のダサチニブ薬剤濃度と治療経過について考察している。

    DOI: 10.1159/000347158

    PubMed

  • Use of per Rectal Portal Scintigraphy to Detect Portal Hypertension in Sinusoidal Obstructive Syndrome following Unrelated Cord Blood Transplantation Reviewed

    Okamura Hiroshi, Hayashi Yoshiki, Nakamae Hirohisa, Shiomi Susumu, Nishimoto Mitsutaka, Koh Hideo, Nakane Takahiko, Hino Masayuki

    ACTA HAEMATOLOGICA   130 ( 2 )   83 - 86   2013( ISSN:0001-5792

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    類洞閉塞症候群(SOS)は、黄疸、腹水、右季肋部痛などの症状を呈する同種造血細胞移植後早期の致死的合併症であるが、鑑別診断が多く診断には困難が伴う。これまで門脈圧亢進がSOSに特徴的であることが示されている。我々は非侵襲的門脈圧測定法である経直腸門脈シンチグラフィーをSOS患者に行った結果、門脈圧亢進所見を得た。経直腸門脈シンチグラフィーはSOS診断に有用である可能性がある。

    DOI: 10.1159/000346438

    PubMed

  • Fatal BK virus pneumonia following stem cell transplantation Reviewed

    Akazawa Y., Terada Y., Yamane T., Tanaka S., Aimoto M., Koh H., Nakane T., Koh K. -R., Nakamae H., Ohsawa M., Wakasa K., Hino M.

    TRANSPLANT INFECTIOUS DISEASE   14 ( 6 )   E142 - E146   2012.12( ISSN:1398-2273

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    DOI: 10.1111/tid.12011

  • CD138-negative clonogenic cells are plasma cells but not B cells in some multiple myeloma patients Reviewed

    Hosen N., Matsuoka Y., Kishida S., Nakata J., Mizutani Y., Hasegawa K., Mugitani A., Ichihara H., Aoyama Y., Nishida S., Tsuboi A., Fujiki F., Tatsumi N., Nakajima H., Hino M., Kimura T., Yata K., Abe M., Oka Y., Oji Y., Kumanogoh A., Sugiyama H.

    LEUKEMIA   26 ( 9 )   2135 - 2141   2012.09( ISSN:0887-6924

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    DOI: 10.1038/leu.2012.80

  • MULTICENTER CLINICAL STUDY EVALUATING THE CONFIRMED CMR TO MMR RATIO AMONG IMATINIB-TREATED CHRONIC PHASE CHRONIC MYELOID LEUKEMIA PATIENTS USING INTERNATIONAL STANDARD RQ-PCR Reviewed

    Shinohara Y., Takahashi N., Nishiwaki K., Miura M., Nakamae H., Hino M., Miyazaki Y., Wakita H., Sawada K.

    HAEMATOLOGICA   97   309 - 309   2012.07( ISSN:0390-6078

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  • リチウム内服患者における好中球増加 Reviewed

    日野 雅之, 左川 均

    血液診療   9 ( 1 )   20 - 21   2012.07

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    50歳男。血液検査で白血球数が20000/mm3以上あったため紹介受診した。発熱等の自覚症状はなく、10年前より白血球増加で骨髄検査を受けたが、異常は指摘されなかった。うつ病に対して10年以上前からソラナックス、リーマス、メイラックスを服用していた。遺伝子検査の結果、慢性骨髄性白血病は否定的で、10年前より白血球増加を指摘されている事からリーマス(リチウム)による白血球増加と診断した。

  • 5番染色体長腕欠失を伴う骨髄異形成症候群に対するレナリドミドの使用経験 Reviewed

    麥谷 安津子, 岡本 秀一郎, 間部 賢寛, 青山 泰孝, 久村 岳央, 太田 忠信, 古川 佳央, 橋村 光晴, 平井 学, 藤谷 洋太朗, 太田 健介, 百瀬 大, 日野 雅之

    血液診療   9 ( 1 )   1 - 7   2012.07

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    5番染色体長腕欠失(5q-)を伴うMDS6例に対してレナリドミドを投与し、1例は投与中に顕性白血病に移行し無効、4例は貧血の改善を認めた。細胞遺伝学的反応は2例に完全寛解、1例に部分寛解が得られた。副作用は血球減少以外には、1例に下肢に深部静脈血栓症を認めた。

  • Different immunoprofiles in patients with chronic myeloid leukemia treated with imatinib, nilotinib or dasatinib. Reviewed

    Hayashi Y, Nakamae H, Katayama T, Nakane T, Koh H, Nakamae M, Hirose A, Hagihara K, Terada Y, Nakao Y, Hino M.

    Leuk Lymphoma   53 ( 6 )   1084 - 1089   2012.06

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  • Diffuse large B cell lymphoma with an interfollicular pattern of proliferation shows a favourable prognosis: a study of the Osaka Lymphoma Study Group Reviewed

    Wada Naoki, Zaki Mona A. A., Kohara Masaharu, Ogawa Hiroyasu, Sugiyama Haruo, Nomura Shosaku, Matsumura Itaru, Hino Masayuki, Kanakura Yuzuru, Inagaki Hiroshi, Morii Eiichi, Aozasa Katsuyuki

    HISTOPATHOLOGY   60 ( 6 )   924 - 932   2012.05( ISSN:0309-0167

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    DOI: 10.1111/j.1365-2559.2011.04161.x

    PubMed

  • 同種骨髄移植後のヒトヘルペスウイルス6(HHV6)脳脊髄炎による遷延性洞性頻脈 Reviewed

    51 ( 10 )   1265 - 1267   2012.05( ISSN:0918-2918

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  • 遺伝子検査 Invited

    日野雅之

    日本臨床   70 Suppl 2   188 - 192   2012.04( ISSN:0047-1852

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    PubMed

  • 好酸球増加症は重症度に関係なく同種造血幹細胞移植後の良好な転帰に関連する Reviewed

    51 ( 8 )   851 - 858   2012.04( ISSN:0918-2918

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  • Complication of pernicious anemia during interferon-β treatment for type C chronic hepatitis Reviewed

    ICHIHARA Hiroyoshi, KOH Shiro, AOYAMA Yasutaka, KUMURA Takeo, OHTA Tadanobu, FURUKAWA Yoshio, TERADA Yoshiki, YAMANE Takahisa, HINO Masayuki, MUGITANI Atsuko

    53 ( 3 )   352 - 356   2012.03( ISSN:04851439

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  • A case of adult-onset Still's disease with macrophage activation syndrome and acute liver failure Reviewed

    FUJII Hideki, TAKEDA Shogo, ASAI Satoru, HAYASHI Yoshiki, IMANISHI Hisayoshi, ENOMOTO Masaru, ISHII Masamitsu, HINO Masayuki, NEGORO Nobuo, ARAKAWA Tetsuo, KAWADA Norifumi

    The Japan Society of Hepatology, Kanzo   53 ( 3 )   155 - 163   2012.03( ISSN:04514203

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    A 26-year-old Japanese woman was admitted to our hospital because of spiking fever, eruption, and liver dysfunction. High fever continued after admission, and antibiotics were not effective. The patient was diagnosed as adult-onset Still's disease after excluding leukemia and malignant lymphoma. Because the patient was complicated with acute liver failure, steroid pulse therapy was started. Although steroid pulse therapy was transiently effective for clinical symptoms, oral predonisolone was not. Moreover, the patient was complicated with severe cytopenia. We diagnosed with macrophage activation syndrome complicated with adult-onset Still's disease. She was treated with cyclosporine A and liposteroid, resulted in complete remission for macrophage activation syndrome and adult-onset Still's disease. In summary of our case, combination of cyclosporine A and liposteroid was effective for the treatment of macrophage activation syndrome with acute liver failure in a patient with adult-onset Still's disease.<br>

    DOI: 10.2957/kanzo.53.155

    CiNii Article

  • A novel thermoelectric cooling device using Peltier modules for inducing local hypothermia of the spinal cord: the effect of local electrically controlled cooling for the treatment of spinal cord injuries in conscious rats. Reviewed

    Morizane K, Ogata T, Morino T, Horiuchi H, Yamaoka G, Hino M, Miura H

    Neuroscience research   72 ( 3 )   279 - 82   2012.03( ISSN:0168-0102

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    DOI: 10.1016/j.neures.2011.12.003

    PubMed

  • INF-β投与中に悪性貧血を合併したC型慢性肝炎

    市原 弘善, 康 史朗, 青山 泰孝, 久村 岳央, 太田 忠信, 古川 佳央, 寺田 芳樹, 山根 孝久, 日野 雅之, 麥谷 安津子

    臨床血液   53 ( 3 )   352 - 356   2012.03( ISSN:0485-1439

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    症例は62歳,男性。近医にてC型慢性肝炎の診断のもとInterferon-β(IFN-β)で治療が開始された。治療開始後29ヵ月2週目にWBC 2,300/μl,Hb 7.2g/dl,PLT 4.7×104/μl,と汎血球減少を認めIFNを中止。しかし,その後も汎血球減少は進行,LDH 4,898IU/lと急激な上昇を認め,当科紹介入院となった。精査の結果,悪性貧血と診断,ビタミンB12投与により速やかな改善が得られた。ウイルス性肝炎に対してIFN治療が広く行われている。それに伴って様々な副作用が報告されているが,悪性貧血合併報告は稀である。IFN加療中に貧血を合併した場合,悪性貧血を鑑別する必要があると考えられ報告する。(著者抄録)

  • Serum Cytokine Profiles in Hemophagocytic Syndrome following Allogeneic Hematopoietic Stem Cell Transplantation. Reviewed

    Koh H, Nakane T, Sakamoto E, Katayama T, Nakamae H, Ohsawa M, Hino M

    Acta Haematol   127 ( 3 )   182 - 185   2012.02

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  • CD48 as a novel molecular target for antibody therapy in multiple myeloma Reviewed

    Hosen Naoki, Ichihara Hiroyoshi, Mugitani Atsuko, Aoyama Yasutaka, Fukuda Yuki, Kishida Satoshi, Matsuoka Yoshikazu, Nakajima Hiroko, Kawakami Manabu, Yamagami Tamotsu, Fuji Shigeo, Tamaki Hiroya, Nakao Takafumi, Nishida Sumiyuki, Tsuboi Akihiro, Iida Shinsuke, Hino Masayuki, Oka Yoshihiro, Oji Yusuke, Sugiyama Haruo

    BRITISH JOURNAL OF HAEMATOLOGY   156 ( 2 )   213 - 224   2012.01( ISSN:0007-1048

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    DOI: 10.1111/j.1365-2141.2011.08941.x

    PubMed

  • Unrelated Peripheral Blood Stem Cell Harvest : Current Status and Future Direction Reviewed

    Hino Masayuki

    31 ( 3 )   209 - 215   2012( ISSN:13405888

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    Allogeneic peripheral blood stem cell transplantation (PBSCT) as well as allogeneic bone marrow transplantation (BMT) is a curative treatment strategy for patients with hematopoietic disorders. PBSCT is associated with more rapid hematopoietic recovery than BMT. Although PBSC harvest is feasible without the risk of anesthesia or invasive multiple bone marrow aspirations, the other concern is the short-term and long-term safety. In a nation-wide prospective survey of the Japan Society for Hematopoietic Cell Transplantation and other worldwide registry data, PBSC harvest was mostly tolerated as well as BM collection. Since the first unrelated PBSCT in 2011, 4 transplants have been performed. Both patients and donors have more therapeutic options by the use of PBSC for unrelated donor transplantation. However, some problems (work-sharing, apheresis center, management of post-transplantation, cryopreservation, etc.) should be solved.

    CiNii Article

  • Immunoglobulin Prophylaxis Against Cytomegalovirus Infection in Patients at High Risk of Infection Following Allogeneic Hematopoietic Cell Transplantation Reviewed

    Ichihara H., Nakamae H., Hirose A., Nakane T., Koh H., Hayashi Y., Nishimoto M., Nakamae M., Yoshida M., Bingo M., Okamura H., Aimoto M., Manabe M., Hagihara K., Terada Y., Nakao Y., Hino M.

    TRANSPLANTATION PROCEEDINGS   43 ( 10 )   3927 - 3932   2011.12( ISSN:0041-1345

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    DOI: 10.1016/j.transproceed.2011.08.104

  • PTHrPの上昇を伴う高Ca血症が認められR-CHOP療法が有効であったB細胞性悪性リンパ腫 Reviewed

    洪 鉉寿, 林 為仁, 萩原 潔通, 杉山 裕之, 安藤 健治, 金 守良, 日野 雅之

    癌と化学療法   38 ( 11 )   1881 - 1884   2011.11( ISSN:0385-0684

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    症例は72歳、男性。意識状態低下、肝脾腫瘤、高Ca血症が認められたため、精査目的で当院に転院した。肝生検の結果、びまん性B細胞性悪性リンパ腫と診断された。高Ca血症に起因する症状は、生理食塩水の点滴、calcitonin製剤の投与などを行い、血清Ca値が改善するとともに消失した。精査結果、血清副甲状腺ホルモン関連蛋白(PTHrP)の上昇およびPTHの低下が認められ、腫瘍細胞から産生されるPTHrPの上昇が高Ca血症の原因と考えられた。全身状態の改善後にR-CHOP療法6コースを施行し、PTHrPの再上昇は観察されず、良好な原疾患の制御が得られている。

  • [Hypercalcemia associated with parathyroid hormone-related protein(PTHrP)in a patient with diffuse large- type B-cell lymphoma(DLBCL)].

    Hong H, Hayashi T, Hagiwara K, Sugiyama H, Ando K, Kim S, Hino M

    Gan to kagaku ryoho. Cancer & chemotherapy   38 ( 11 )   1881 - 4   2011.11( ISSN:0385-0684

  • Predictability of the response to tyrosine kinase inhibitors via in vitro analysis of Bcr-Abl phosphorylation Reviewed

    Shibata Masaru, Ezoe Sachiko, Oritani Kenji, Matsui Keiko, Tokunaga Masahiro, Fujita Natsuko, Saito Yuri, Takahashi Takayuki, Hino Masayuki, Matsumura Itaru, Kanakura Yuzuru

    LEUKEMIA RESEARCH   35 ( 9 )   1205 - 1211   2011.09( ISSN:0145-2126

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    DOI: 10.1016/j.leukres.2011.01.012

    PubMed

  • Membranous nephropathy with nephrotic syndrome developed after allogeneic hematopoietic stem cell transplantation for acute lymphoblastic leukemia Reviewed

    AIMOTO Mizuki, YAMANE Takahisa, ICHII Mitsuru, MORI Katsuhito, MORIGUCHI AIMOTO Ran, WADA INOUE Eri, KOH Hideo, NAKANE Takahiko, TAKEOKA Yasunobu, AKAHORI NAKAMAE Mika, NISHIKI KOSAKA Saori, TERADA Yoshiki, NAKAMAE Hirohisa, KOH Ki-Ryang, NAKAO Takafumi, OHSAWA Masahiko, WAKASA Kenichi, ISHIMURA Eiji, INABA Masaaki, HINO Masayuki

    The Japanese Society of Hematology, Rinsho Ketsueki   52 ( 7 )   556 - 562   2011.07( ISSN:04851439

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    A 38-year-old man was diagnosed with acute lymphoblastic leukemia. We performed myeloablative bone marrow transplantation from an unrelated donor during the patient's first complete remission. After engraftment, he developed acute graft-versus-host disease involving the gastrointestinal tract on day 32. Steroids and mycophenolate mofetil were initiated from day 39. His symptoms improved and the dose of immunosuppressants was tapered and then discontinued on day 421. On day 491, he developed nephrotic syndrome (NS). Based on renal biopsy, membranous nephropathy was diagnosed. There were no apparent symptoms or abnormal laboratory data suggestive of chronic graft-versus-host disease (cGVHD). Steroid therapy was initiated from day 518 and proteinuria improved significantly. NS is very rare following allogeneic hematopoietic stem cell transplantation (allo-HSCT). When there is no concomitant cGVHD, as in this case, allo-HSCT-associated NS is difficult to distinguish from idiopathic NS.

    DOI: 10.11406/rinketsu.52.556

    CiNii Article

  • Severe prekallikrein deficiency due to a homozygous Trp499Stop nonsense mutation Reviewed

    Nakao Takafumi, Yamane Takahisa, Katagami Tomoko, Shiota Masayuki, Izumi Yasukatsu, Samori Tomohiro, Hino Masayuki, Iwao Hiroshi

    BLOOD COAGULATION & FIBRINOLYSIS   22 ( 4 )   337 - 339   2011.06( ISSN:0957-5235

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    DOI: 10.1097/MBC.0b013e3283444ddb

    PubMed

  • Chronic myelogenous leukemia complicated by drug-induced agranulocytosis Reviewed

    NAKAO Takafumi, YOSHIDA Noriko, NAKANE Takahiko, TERADA Yoshiki, NAKAMAE Hirohisa, KOH Ki-Ryang, YAMANE Takahisa, HINO Masayuki

    The Japanese journal of clinical hematology   52 ( 5 )   278 - 281   2011.05( ISSN:04851439

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  • Presence of B-cell clones in T-cell lymphoma Reviewed

    Zaki Mona A. A., Wada Naoki, Kohara Masaharu, Ikeda Junichiro, Hori Yumiko, Fujita Shigeki, Ogawa Hiroyasu, Sugiyama Haruo, Hino Masayuki, Kanakura Yuzuru, Morii Eiichi, Aozasa Katsuyuki

    EUROPEAN JOURNAL OF HAEMATOLOGY   86 ( 5 )   412 - 419   2011.05( ISSN:0902-4441

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    DOI: 10.1111/j.1600-0609.2011.01597.x

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  • Seven-year follow-up of patients receiving imatinib for the treatment of newly diagnosed chronic myelogenous leukemia by the TARGET system Reviewed

    Tauchi Tetsuzo, Kizaki Masahiro, Okamoto Shinichiro, Tanaka Hideo, Tanimoto Mitsune, Inokuchi Koiti, Murayama Tohru, Saburi Yoshio, Hino Masayuki, Tsudo Mitsuru, Shimomura Taizo, Isobe Yasushi, Oshimi Kazuo, Dan Kazuo, Ohyashiki Kazuma, Ikeda Yasuo

    LEUKEMIA RESEARCH   35 ( 5 )   585 - 590   2011.05( ISSN:0145-2126

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    DOI: 10.1016/j.leukres.2010.10.027

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  • Frequency of intravascular large B-cell lymphoma in Japan: Study of the Osaka Lymphoma Study Group Reviewed

    Chihara Takeshi, Wada Naoki, Ikeda Junichiro, Fujita Shigeki, Hori Yumiko, Ogawa Hiroyasu, Sugiyama Haruo, Nomura Shosaku, Matsumura Itaru, Hino Masayuki, Kanakura Yuzuru, Morii Eiichi, Aozasa Katsuyuki

    JOURNAL OF HEMATOLOGY & ONCOLOGY   4   14   2011.04( ISSN:1756-8722

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    DOI: 10.1186/1756-8722-4-14

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  • Factors that contribute to long-term survival in patients with leukemia not in remission at allogeneic hematopoietic cell transplantation Reviewed

    Koh Hideo, Nakamae Hirohisa, Hagihara Kiyoyuki, Nakane Takahiko, Manabe Masahiro, Hayashi Yoshiki, Nishimoto Mitsutaka, Umemoto Yukari, Nakamae Mika, Hirose Asao, Inoue Eri, Inoue Atsushi, Yoshida Masahiro, Bingo Masato, Okamura Hiroshi, Aimoto Ran, Aimoto Mizuki, Terada Yoshiki, Koh Ki-Ryang, Yamane Takahisa, Ohsawa Masahiko, Hino Masayuki

    JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH   30   36   2011.04( ISSN:1756-9966

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/1756-9966-30-36

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  • 非血縁者間骨髄移植における追加的放射線照射およびT細胞除去を伴わないフルダラビン/ブスルファンによる骨髄非破壊的前処置は無再発死亡率を低下させる Reviewed

    93 ( 4 )   509 - 516   2011.04( ISSN:0925-5710

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  • 免疫抑制療法を受けた関節リウマチ患者におけるB型肝炎ウイルス再活性化に関する前向き研究 HBsAg陽性コホートとHBsAg陰性コホートの評価 Reviewed

    46 ( 4 )   556 - 564   2011.04( ISSN:0944-1174

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  • 日本の同種造血幹細胞移植患者におけるミコフェノール酸モフェチル使用 Reviewed

    93 ( 4 )   523 - 531   2011.04( ISSN:0925-5710

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  • Epstein-Barr Virus in Diffuse Large B-Cell Lymphoma in Immunocompetent Patients in Japan is as Low as in Western Countries Reviewed

    Wada Naoki, Ikeda Junichiro, Hori Yumiko, Fujita Shigeki, Ogawa Hiroyasu, Soma Toshihiro, Sugiyama Haruo, Fukuhara Shirou, Kanamaru Akihisa, Hino Masayuki, Kanakura Yuzuru, Morii Eiichi, Aozasa Katsuyuki

    JOURNAL OF MEDICAL VIROLOGY   83 ( 2 )   317 - 321   2011.02( ISSN:0146-6615

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    DOI: 10.1002/jmv.21967

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  • Epstein-Barr virus-associated post-transplant lymphoproliferative disorder diagnosed by the episode of intestinal perforation following allogeneic hematopoietic stem cell transplantation Reviewed

    AIMOTO Mizuki, YAMANE Takahisa, INOUE Atushi, MOMOSE Dai, MORIGUCHI AIMOTO Ran, WADA INOUE Eri, OKAMOTO Syuuichirou, KOH Hideo, NAKANE Takahiko, TAKEOKA Yasunobu, AKAHORI NAKAME Mika, NISHIKI KOSAKA Saori, TERADA Yoshiki, NAKAMAE Hirohisa, KOH Ki-Ryang, NAKAO Takafumi, OHSAWA Masahiko, HINO Masayuki

    The Japanese journal of clinical hematology   51 ( 12 )   1775 - 1780   2010.12( ISSN:04851439

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  • Cytosine-arabinosideはヒト骨髄間質細胞の正常な造血を補助する能力を高める Reviewed

    56 ( 2 )   11 - 20   2010.12( ISSN:0030-6096

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  • Safety and Risk of Allogeneic Peripheral Blood Stem Cell Donation: The Comprehensive Report of Nation-Wide Consecutively Pre-Registered 3,264 Family Donor Survey In 10years Project by Japan Society for Hematopoietic Cell Transplantation Reviewed

    Kodera Yoshihisa, Yamamoto Kazuhito, Kato Shunichi, Harada Mine, Kanda Yoshinobu, Hamajima Nobuyuki, Asano Shigetaka, Ikeda Yasuo, Imamura Masahiro, Kawa Keisei, Morishima Yasuo, Nakahata Tatsutoshi, Tanimoto Mitsune, Dohy Hiroo, Tanosaki Ryuji, Shiobara Shintaro, Kim Sung-Won, Nagafuji Koji, Hino Masayuki, Miyamura Koichi, Suzuki Ritsuro

    BLOOD   116 ( 21 )   508   2010.11( ISSN:0006-4971

  • 同種造血幹細胞移植後のリポソーマルアムホテリシンB投与中に新規発症したトリコスポロン血症の一例

    康 秀男, 井上 恵里, 中根 孝彦, 武岡 康信, 相本 蘭, 相本 瑞樹, 寺田 芳樹, 中前 博久, 高 起良, 山根 孝久, 大澤 政彦, 日野 雅之

    血液フロンティア   20 ( 12 )   2176 - 2179   2010.11( ISSN:1344-6940

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    63歳女。骨髄異形成症候群からの急性骨髄性白血病と診断され、化学療法で寛解後に非血縁骨髄移植を施行したが骨髄再発した。再寛解導入療法を施行し、第2寛解後に再度非血縁骨髄移植を施行した。day28に好中球生着を確認したが、day32以降にアデノウイルスによる出血性膀胱炎およびウイルス血症、サイトメガロウイルス抗原血症、腎出血を発症し、ribavirin、gancyclovir、血小板輸血などを使用した。day83にCRP高値が続き、liposomal amphoptericin B(L-AMB)を5mg/kg/dayに変更した。いったん改善したが、day104より発熱が出現し、β-Dグルカン著明上昇を認め、静脈血液培養で酵母様真菌が検出され、後日Trichosporon spp.と判明した。day108よりvoriconazole 400mg/dayとmicafungin 300mg/dayの点滴に変更したところ、翌日には解熱し、β-Dグルカンも減少し、血液培養陰性を確認した。しかし、day 122より再び発熱し、翌日Stenotrophomonas maltophilia敗血症で死亡した。

  • Unrelated Peripheral Blood Stem Cell Transplantation

    HinoMasayuki

    29 ( 3 )   247 - 252   2010.10

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    Allogeneic peripheral blood stem cell transplantation (PBSCT) as well as allogeneic bone marrow transplantation (BMT) is a curative treatment strategy for patients with hematopoietic disorders. PBSCT is associated with more rapid hematopoietic recovery than BMT. Although PBSC harvest is feasible without the risk of anesthesia or invasive multiple bone marrow aspirations, the other concern is the short-term and long-term safety. In a nation-wide prospective survey of the Japan Society for Hematopoietic Cell Transplantation and other worldwide registry data, PBSC harvest was mostly tolerated as well as BM collection. Both patients and donors have more therapeutic options for unrelated donor transplantation with the use of PBSC. However, some problems (safe procedure for donor, inspection and accreditation of hospital, work-sharing, apheresis center, management of post-transplantation, cryopreservation, etc.) should be dealt with.

    CiNii Article

  • 進行期白血病に対する静注Busulfan(Busulfex)+Cyclophosphamide+Total Lymphoid Irradiationを用いたModified Myeloablative Conditioningによる同種造血幹細胞移植 Reviewed

    中前 博久, 寺田 芳樹, 中根 孝彦, 康 秀男, 中前 美佳, 相本 蘭, 廣瀬 朝生, 林 良樹, 西本 光孝, 井上 恵里, 吉村 卓朗, 井上 敦司, 高 起良, 山根 孝久, 日野 雅之

    癌と化学療法   37 ( 9 )   1691 - 1695   2010.09( ISSN:0385-0684

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    同種造血幹細胞移植の移植前処置の強度の最適化を検討する目的で静注busulfan +cyclophosphamide+total lymphoid irradiation(TLI)によるmodified myeloablative conditioning regimenにて進行期の急性、慢性白血病9例に対して同種造血幹細胞移植を行った。急性GVHDは9人中6例(67%)に出現し、全例でgrade 2であった。広範型慢性GVHDは評価可能症例7例中3例に認められた。移植後観察期間中央値は813(248〜1702)日で、9例中5例で移植後に原疾患の再発、再燃を認めたが、移植後100日以内の再発例はなかった。移植全観察期間を通じて移植関連死亡は認めなかった。2年の全生存率は88.9%、無病生存率は50.0%であった。

  • 同種骨髄移植後の内臓播種性水痘帯状疱疹ウイルス感染症に合併した血球貪食症候群の診断に血清フェリチンが有用であった1例 Reviewed

    宮本 奈津子, 康 秀男, 中根 孝彦, 和田 恵里, 相本 瑞樹, 相本 蘭, 武岡 康信, 寺田 芳樹, 中前 博久, 高 起良, 山根 孝久, 大澤 政彦, 日野 雅之

    診断と治療   98 ( 9 )   1539 - 1542   2010.09( ISSN:0370-999X

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    24歳女。急性骨髄性白血病にて骨髄移植を受けたが再発し、再移植受け、寛解状態であったが、便秘、上腹部痛、汎血球減少、肝障害、フェリチン高値を認め、その後、全身に散在性の水疱が出現し、生検で巨細胞を認め、VZV-DNA高値であり、内臓播種性水痘帯状疱疹ウイルス感染症と確定診断した。

  • [A modified myeloablative conditioning regimen for allogeneic hematopoietic stem cell transplantation, consisting of intravenous busulfan, cyclophosphamide and total lymphoid irradiation, in advanced leukemia].

    Nakamae H, Terada Y, Nakane T, Koh H, Nakamae M, Aimoto R, Hirose A, Hayashi Y, Nishimoto M, Inoue E, Yoshimura T, Inoue A, Koh KR, Yamane T, Hino M

    Gan to kagaku ryoho. Cancer & chemotherapy   37 ( 9 )   1691 - 5   2010.09( ISSN:0385-0684

  • Acrodermatitis continua of Hallopeau appearing at specific, high leucocyte counts Reviewed

    Kurooka S., Tsuruta D., Hino M., Yanagihara S., Ishii M.

    BRITISH JOURNAL OF DERMATOLOGY   163 ( 2 )   428 - 430   2010.08( ISSN:0007-0963

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    DOI: 10.1111/j.1365-2133.2010.09792.x

  • A rare t(4;12)(q12;p13) in an adolescent patient with acute myeloid leukemia Reviewed

    Manabe Masahiro, Nakamura Koji, Inaba Akiko, Fujitani Yotaro, Kosaka Saori, Yamamura Ryosuke, Inoue Atsushi, Hino Masayuki, Senzaki Hideto, Ohta Kensuke

    CANCER GENETICS AND CYTOGENETICS   200 ( 1 )   70 - 72   2010.07( ISSN:0165-4608

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    DOI: 10.1016/j.cancergencyto.2010.03.012

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  • 自己移植患者および同種移植ドナーにおける末梢血幹細胞白血球除去療法中および療法後の心拍変動 Reviewed

    91 ( 3 )   478 - 484   2010.04( ISSN:0925-5710

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  • Polymorphous lymphoproliferative disorder: a clinicopathological analysis Reviewed

    Nakamichi Naoto, Wada Naoki, Kohara Masaharu, Fukuhara Shirou, Sugiyama Haruo, Ogawa Hiroyasu, Hino Masayuki, Kanamaru Akihisa, Kanakura Yuzuru, Morii Eiichi, Aozasa Katsuyuki

    VIRCHOWS ARCHIV   456 ( 3 )   269 - 276   2010.03( ISSN:0945-6317

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    DOI: 10.1007/s00428-010-0880-1

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  • 当院における造血細胞移植前の口腔内感染症スクリーニングの検討 Reviewed

    間部 賢寛, 京本 博行, 山村 亮介, 稲葉 晃子, 藤谷 洋太朗, 小坂 さおり, 松田 信彦, 西川 典良, 瀧田 正亮, 金島 広, 手島 博文, 相本 蘭, 日野 雅之, 太田 健介

    血液診療   7 ( 1 )   10 - 14   2010.02

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    移植前に口腔内診査を行った18例に対し口腔内感染源と対処法について検討した。歯科疾患は16例(88.8%)に合併しており、齲歯13歯、歯髄炎6歯、根尖性歯周炎24歯、辺縁性歯周炎14例、埋伏智歯5歯を認めた。処置として抜歯20歯、抜髄6歯、修復処置3歯、感染根管治療7歯及び歯石除去14例を施行し、全例において前処置開始から移植後に歯性感染症はみられなかった。

  • Diffuse large B-cell lymphoma in the spinal epidural space: A study of the Osaka Lymphoma Study Group Reviewed

    Wada Naoki, Kohara Masaharu, Ikeda Junichiro, Hori Yumiko, Fujita Shigeki, Okada Masaya, Ogawa Hiroyasu, Sugiyama Haruo, Fukuhara Shirou, Kanamaru Akihisa, Hino Masayuki, Kanakura Yuzuru, Morii Eiichi, Aozasa Katsuyuki

    PATHOLOGY RESEARCH AND PRACTICE   206 ( 7 )   439 - 444   2010( ISSN:0344-0338

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    DOI: 10.1016/j.prp.2010.02.003

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  • Serum Cytokine Profiles at the Onset of Severe, Diffuse Alveolar Hemorrhage Complicating Allogeneic Hematopoietic Stem Cell Transplantation, Treated Successfully with Pulse Intravenous Cyclophosphamide Reviewed

    Koh Hideo, Nakamae Hirohisa, Koh Ki-Ryang, Ohsawa Masahiko, Nakane Takahiko, Takeoka Yasunobu, Aimoto Ran, Aimoto Mizuki, Wada-Inoue Eri, Terada Yoshiki, Yamane Takahisa, Hino Masayuki

    ACTA HAEMATOLOGICA   124 ( 3 )   171 - 175   2010( ISSN:0001-5792

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    DOI: 10.1159/000318013

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  • Change of CD20 Expression in Diffuse Large B-Cell Lymphoma Treated with Rituximab, an Anti-CD20 Monoclonal Antibody: A Study of the Osaka Lymphoma Study Group. Reviewed

    Wada N, Kohara M, Ogawa H, Sugiyama H, Fukuhara S, Tatsumi Y, Kanamaru A, Hino M, Kanakura Y, Morii E, Aozasa K

    Case reports in oncology   2 ( 3 )   194 - 202   2009.10

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    DOI: 10.1159/000249152

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  • 心機能低下を有する血液疾患患者に対する強度減弱同種造血細胞移植後の心機能および自律神経機能 Reviewed

    88 ( 9 )   871 - 879   2009.09( ISSN:0939-5555

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    DOI: 10.1007/s00277-009-0695-9

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  • Diffuse large B-cell lymphoma with a high number of epithelioid histiocytes (lymphoepithelioid B-cell lymphoma): a study of Osaka Lymphoma Study Group Reviewed

    Wada Naoki, Ikeda Junichiro, Kohara Masaharu, Ogawa Hiroyasu, Hino Masayuki, Fukuhara Shirou, Kanamaru Akihisa, Sugiyama Haruo, Kanakura Yuzuru, Morii Eiichi, Aozasa Katsuyuki

    VIRCHOWS ARCHIV   455 ( 3 )   285 - 293   2009.09( ISSN:0945-6317

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00428-009-0827-6

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  • Long-term survival after HLA-haploidentical SCT from noninherited maternal antigen-mismatched family donors: impact of chronic GVHD Reviewed

    Kanda J., Ichinohe T., Shimazaki C., Hamaguchi M., Watanabe A., Ishida H., Yoshihara T., Morimoto A., Uoshima N., Adachi S., Inukai T., Sawada A., Oka K., Itoh M., Hino M., Maruya E., Saji H., Uchiyama T., Kodera Y.

    BONE MARROW TRANSPLANTATION   44 ( 5 )   327 - 329   2009.09( ISSN:0268-3369

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    DOI: 10.1038/bmt.2009.18

  • Impact of relative dose intensity (RDI) in CHOP combined with rituximab (R-CHOP) on survival in diffuse large B-cell lymphoma Reviewed

    Terada Yoshiki, Nakamae Hirohisa, Aimoto Ran, Kanashima Hiroshi, Sakamoto Erina, Aimoto Mizuki, Inoue Eri, Koh Hideo, Nakane Takahiko, Takeoka Yasunobu, Ohsawa Masahiko, Koh Ki-Ryang, Yamane Takahisa, Nakao Yoshitaka, Ohta Kensuke, Mugitani Atsuko, Teshima Hirofumi, Hino Masayuki

    JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH   28   116   2009.08( ISSN:1756-9966

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    DOI: 10.1186/1756-9966-28-116

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  • Long-term efficacy of Helicobacter pylori eradication in patients with idiopathic thrombocytopenic purpura: 7-year follow-up prospective study Reviewed

    Tsumoto C., Tominaga K., Okazaki H., Tanigawa T., Yamagami H., Watanabe K., Nakao T., Koh K., Watanabe T., Fujiwara Y., Yamane T., Oshitani N., Hino M., Higuchi K., Arakawa T.

    ANNALS OF HEMATOLOGY   88 ( 8 )   789 - 793   2009.08( ISSN:0939-5555

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    DOI: 10.1007/s00277-008-0667-5

  • Efficacy and safety of intravenous itraconazole as empirical antifungal therapy for persistent fever in neutropenic patients with hematological malignancies in Japan Reviewed

    Ohta Kensuke, Kosaka Saori Nishiki, Nakao Yoshitaka, Kumura Takeo, Hagihara Kiyomichi, Sakamoto Erina, Okamoto Shuichiro, Hirose Asao, Aoyama Yasutaka, Yamamura Ryousuke, Hayashi Yoshiki, Umemoto Yukari, Terada Yoshiki, Takeoka Yasunobu, Nakane Takahiko, Koh Hideo, Hino Masayuki

    INTERNATIONAL JOURNAL OF HEMATOLOGY   89 ( 5 )   649 - 655   2009.06( ISSN:0925-5710

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    DOI: 10.1007/s12185-009-0316-3

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  • Intrathecal transplantation of autologous macrophages genetically modified to secrete proenkephalin ameliorated hyperalgesia and allodynia following peripheral nerve injury in rats. Reviewed

    Hino M, Ogata T, Morino T, Horiuchi H, Yamamoto H

    Neuroscience research   64 ( 1 )   56 - 62   2009.05( ISSN:0168-0102

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    DOI: 10.1016/j.neures.2009.01.011

  • CNS Complications of Hematopoietic Stem Cell Transplantation Reviewed

    Nishiguchi Tomokazu, Mochizuki Kunizo, Shakudo Miyuki, Takeshita Tohru, Hino Masayuki, Inoue Yuichi

    AMERICAN JOURNAL OF ROENTGENOLOGY   192 ( 4 )   1003 - 1011   2009.04( ISSN:0361-803X

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    DOI: 10.2214/AJR.08.1787

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  • 今月の主題 末梢血検査異常 何を考え,どう対応するか 血液疾患へのアプローチ 【白血球系の異常】 白血球数の減少

    北川 誠一, 日野 雅之

    medicina   45 ( 12 )   2206 - 2208   2008.12( ISSN:00257699

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  • Current and future perspectives on the TARGET system: the registration system for Glivec (R) established by the JSH Reviewed

    Kizaki Masahiro, Okamoto Shinichiro, Tauchi Tetsuzo, Tanaka Hideo, Tanimoto Mitsune, Inokuchi Koiti, Murayama Tohru, Saburi Yoshio, Hino Masayuki, Tsudo Mitsuru, Shimomura Taizo, Isobe Yasushi

    INTERNATIONAL JOURNAL OF HEMATOLOGY   88 ( 4 )   409 - 417   2008.11( ISSN:0925-5710

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    DOI: 10.1007/s12185-008-0186-0

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  • Chronic myeloid leukemia in two patients with gastrointestinal stromal tumor Reviewed

    Sakamoto Erina, Sawada Tetsuji, Osugi Harushi, Nakamae Hirohisa, Koh Ki-Ryang, Yamane Takahisa, Ohsawa Masahiko, Wakasa Kenichi, Hino Masayuki

    INTERNATIONAL JOURNAL OF HEMATOLOGY   88 ( 3 )   348 - 350   2008.10( ISSN:0925-5710

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    DOI: 10.1007/s12185-008-0151-y

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  • Platelet-associated IgG for the diagnosis of immune thrombocytopaenic purpura during peginterferon alpha and ribavirin treatment for chronic hepatitis C Reviewed

    Enomoto Masaru, Yamane Takahisa, Hino Masayuki, Ohnishi Miho, Tamori Akihiro, Kawada Norifumi

    LIVER INTERNATIONAL   28 ( 9 )   1314 - 1315   2008.10( ISSN:1478-3223

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    DOI: 10.1111/j.1478-3231.2008.01747.x

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  • 悪性リンパ腫診療update in 2008 最新のエビデンスに基づく診断と治療 悪性リンパ腫を捉える 正確な診断に必要な方法論 予後予測因子とは 適切な臨床決断のために

    寺田 芳樹, 日野 雅之

    内科   102 ( 2 )   267 - 270   2008.08( ISSN:00221961

  • 同種造血細胞移植前血清SP-D値は移植後閉塞性細気管支炎(BOS)および特発性肺炎症候群(IPS)発症予測に有用である Reviewed

    42 ( 1 )   43 - 49   2008.07( ISSN:0268-3369

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    DOI: 10.1038/bmt.2008.73

  • Diffuse large B-cell lymphoma showing an interfollicular pattern of proliferation: a study of the Osaka Lymphoma Study Group Reviewed

    Yamauchi A., Ikeda J., Nakamichi I., Kohara M., Fukuhara S., Hino M., Kanakura Y., Ogawa H., Sugiyama H., Kanamaru A., Aozasa K.

    HISTOPATHOLOGY   52 ( 6 )   731 - 737   2008.05( ISSN:0309-0167

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    DOI: 10.1111/j.1365-2559.2008.03018.x

  • Hematopoietic cell transplantation and clinical chemistry Invited Reviewed

    HINO Masayuki, NAKAMAE Hirohisa, KOH Ki-ryang, YAMANE Takahisa

    37 ( 2 )   107 - 115   2008.04( ISSN:03705633

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  • Calcium channel blockers suppress cytokine-induced activation of human neutrophils Reviewed

    Shima Etsuko, Katsube Masataka, Kato Takayuki, Kitagawa Maki, Hato Fumihiko, Hino Masayuki, Takahashi Tatsuji, Fujita Hisakazu, Kitagawa Seiichi

    AMERICAN JOURNAL OF HYPERTENSION   21 ( 1 )   78 - 84   2008.01( ISSN:0895-7061

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    DOI: 10.1038/ajh.2007.13

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  • The expression of anamorsin in diffuse large B cell lymphoma: Possible prognostic biomarker for low IPI patients Reviewed

    Shizusawa Takae, Shibayama Hirohiko, Murata Shinsuke, Saitoh Yuri, Sugimoto Yuna, Matsumura Itaru, Ogawa Hiroyasu, Sugiyama Haruo, Fukuhara Shirou, Hino Masayuki, Kanamaru Akihisa, Yamauchi Amane, Aozasa Katsuyuki, Kanakura Yuzuru

    LEUKEMIA & LYMPHOMA   49 ( 1 )   113 - 121   2008( ISSN:1042-8194

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    DOI: 10.1080/10428190701713697

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  • TRANSFUSION-TRANSMITTED HBV INFECTION DETECTED BY LOOKBACK STUDY FOR BLOOD DONOR-A CASE REPORT Reviewed

    Tamori Akihiro, Fujino Keizo, Oshima Shigeko, Takeda Kazuhiro, Kawada Norifumi, Hino Masayuki, Nishiguchi Shuhei

    The Japan Society of Transfusion Medicine and Cell Therapy, Journal of the Japan Society of Blood Transfusion   54 ( 3 )   393 - 397   2008( ISSN:1881-3011

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    We experienced a 61-year-old male patient with acute leukemia who was diagnosed with hepatitis B virus (HBV) infection after blood transfusion. At 3 months after transfusion, a blood sample from the same donor was positive for HBV DNA on 50-pooled sample nucleic acid amplification testing (NAT). Lookback study showed that the first donated blood was negative for HBV DNA on 50-pooled sample NAT but positive on individual sample NAT (ID-NAT). Before transfusion, the patient was negative for HBsAg and anti-HBc. HBV DNA sequence analysis of the patient and of the donor showed 99% homology. Lamivudine treatment was started, and prevented acute hepatitis B. The present patient was a member of the ID-NAT screening study for post-transfusion infection. In eight of 921 patients (excluding the present patient), HBV DNA was detected only after blood transfusion. Seven of these eight patients were positive for anti-HBc was positive and four had been transfused during chemotherapy for neoplasm. Retrospective study of all donor samples showed no detection of HBV DNA by ID-NAT. Recently it was reported that cytotoxic chemotherapy induced HBV reactivation in patients with past HBV infection. We therefore speculate that HBV reactivation occurred in some of our eight patients positive for HBV DNA after blood transfusion.<br>

    DOI: 10.3925/jjtc.54.393

    CiNii Article

  • :A Study in Three Hospitals in Osaka City, 2005-2006 Reviewed

    SHIMOUCHI Akira, GOTO Tetsushi, SHIRASAKA Takuma, HINO Masayuki

    The Japanese Society for AIDS Research, The Journal of AIDS Research   10 ( 3 )   206 - 214   2008( ISSN:1344-9478

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    <I>Objective</I>: To measure the effects of attendance and treatment of HIV/AIDS patients at outpatient department on clinical, laboratory results, and sexual behavior.<BR><B>Subjects and Methods</B>: A study was conducted through a questionnaire and review of medical records for HIV/AIDS patients attending outpatient departments in three hospitals in Osaka City in 2005-2006.<BR>Results: (1) Conditions at HIV Testing upon Diagnosis and Sexual Behavior<BR>127HIV/AIDS patients in 3 hospitals replied to the questionnaire. 97.6% of them were male. Most (85.1%) of the residents in Osaka City attended health facility for HIV test within the city. 93.5% of 123 persons visited medical facilities within one month after HIV positive results were given. 81.5% of persons diagnosed at medical facilities "visited" medical facilities in a week for further examination and treatment, while 48.4% of persons diagnosed at city and ward public health offices did so in a week. 77% of them reduced risky sexual behavior in the past 6 months compared with the period prior to HIV positive results being known. In particular, 80.6% of persons diagnosed at city and ward public health offices reduced risky sexual behavior. It was more than that (65.6%) of persons diagnosed at medical facilities. The difference is statistically significant (x<SUP>2</SUP> test, p< 0.05).<BR>(2) The effects of treatment on symptoms and laboratory tests 59 HIV/AIDS patients in 3 hospitals agreed to examination of their medical charts. 18.5% of them experienced default to attend the outpatient department on their scheduled dates in 2005-2006.35 received HAART and only one patient (2.9%) stopped treatment for more than 2 months. Symptoms improved or have not changed in 88.2% and viral load & CD4 count improved or have not changed in 81.3% of patients.<BR><B>Conclusion</B>: As most of the HIV/AIDS patients who regularly receive medical consultation and treatment improved symptoms and laboratory results, efforts on early case finding and early treatment would lead to reduction of HIV infection in future. Therefore it is important to increase opportunity further for HIV testing.

    DOI: 10.11391/aidsr1999.10.206

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  • Diffuse large B-cell lymphoma in the young in Japan: A study by the Osaka Lymphoma Study Group Reviewed

    Yamauchi Amane, Fujita Shigeki, Ikeda Junichiro, Nakamichi Itsuki, Fukuhara Shiro, Hino Masayuki, Kanakura Yuzuru, Ogawa Hiroyasu, Sugiyama Haruo, Kanamaru Akihisa, Aozasa Katsuyuki

    AMERICAN JOURNAL OF HEMATOLOGY   82 ( 10 )   893 - 897   2007.10( ISSN:0361-8609

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    DOI: 10.1002/ajh.20968

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  • Prospective phase II trial to evaluate the complications and kinetics of chimerism induction following allogeneic hematopoietic stem cell transplantation with fludarabine and busulfan Reviewed

    Saito Akiko M., Kami Masahiro, Mori Shin-Ichiro, Kanda Yoshinobu, Suzuki Ritsuro, Mineishi Shin, Takami Akiyoshi, Taniguchi Shuichi, Takemoto Yoshinobu, Hara Masamichi, Yamaguchi Masaki, Hino Masayuki, Yoshida Takashi, Kim Sung-Won, Hori Akiko, Ohashi Yasuo, Takaue Yoichi

    AMERICAN JOURNAL OF HEMATOLOGY   82 ( 10 )   873 - 880   2007.10( ISSN:0361-8609

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    DOI: 10.1002/ajh.20977

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  • Real-time direct measurement of spinal cord blood flow at the site of compression: relationship between blood flow recovery and motor deficiency in spinal cord injury. Reviewed

    Hamamoto Y, Ogata T, Morino T, Hino M, Yamamoto H

    Spine   32 ( 18 )   1955 - 62   2007.08( ISSN:0362-2436

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1097/BRS.0b013e3181316310

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  • Correlation between promoter hypermethylation of GSTP1 and response to chemotherapy in diffuse large B cell lymphoma Reviewed

    Nakamichi Itsuko, Tomita Yasuhiko, Zhang Binglin, Sugiyama Haruo, Kanakura Yuzuru, Fukuhara Shirou, Hino Masayuki, Kanamaru Akihisa, Ogawa Hiroyasu, Aozasa Katsuyuki

    ANNALS OF HEMATOLOGY   86 ( 8 )   557 - 564   2007.08( ISSN:0939-5555

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    DOI: 10.1007/s00277-007-0299-1

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  • Prophylactic fresh frozen plasma may prevent development of hepatic VOD after stem cell transplantation via ADAMTS13-mediated restoration of von Willebrand factor plasma levels Reviewed

    Matsumoto M., Kawa K., Uemura M., Kato S., Ishizashi H., Isonishi A., Yagi H., Park Y-D, Takeshima Y., Kosaka Y., Hara H., Kai S., Kanamaru A., Fukuhara S., Hino M., Sako M., Hiraoka A., Ogawa H., Hara J., Fujimura Y.

    BONE MARROW TRANSPLANTATION   40 ( 3 )   251 - 259   2007.08( ISSN:0268-3369

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    DOI: 10.1038/sj.bmt.1705724

  • Necrotizing fasciitis caused by Staphylococcus aureus in chronic myeloproliferative disease

    61 ( 7 )   558 - 561   2007.06( ISSN:00214973

  • 寛解導入療法中に脳膿瘍を合併し救命し得た急性骨髄性白血病 Reviewed

    中根孝彦、山根孝久、中前博久、市原弘善、康 秀男、武岡康信、金島 広、坂本恵利奈、高 起良、日野雅之

    癌と化学療法   34 ( 5 )   789 - 792   2007.05( ISSN:0385-0684

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  • Allogeneic hematopoietic stem cell transplantation for adult T cell leukemia: Result of a single center study Reviewed

    Koh Hideo., Koh Ki-Ryang., Hagihara Kiyoyuki., Nakane Takahiko., Takeoka Yasunobu, Kanashima Hiroshi., Sakamoto Erina, Nakamae Mika, Ichihara Hiroyoshi., Terada Yoshiki., Nakamae Hirohisa., Ohta Kensuke., Yamane Takahisa., Watanabe Toshiki., Hino Masayuki.

    AIDS RESEARCH AND HUMAN RETROVIRUSES   23 ( 4 )   604 - 605   2007.04( ISSN:0889-2229

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  • A multicentric Castleman disease-like case characterized by lymphadenopathy and polyclonal hypergammaglobulinemia associated with so-called Mikulicz disease Reviewed

    OHTA Tadanobu, FURUKAWA Yoshio, AOYAMA Yasutaka, KUMURA Takeo, MUGITANI Atsuko, NAKAMAE Hirohisa, KOH Kyron, YAMANE Takahisa, HINO Masayuki

    The Japanese Society of Hematology, Rinsho Ketsueki   48 ( 3 )   229 - 234   2007.03( ISSN:04851439

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    A 73-year-old male was admitted in January 1999 with hyperimmunoglobulinemia with a serum IgG level of 6530 mg/d<i>l</i>, bilateral eyelid tumors, bilateral submandibular swelling, and swelling of the superficial lymph nodes. A left submandibular gland biopsy showed severe chronic sialoadenitis with fibrosis. A left cervical lymph node biopsy showed invasion by many mature lymphocytes and plasma cells, but no lymphoma cells. The patient was diagnosed as having so-called Mikulicz disease associated with a disease similar to multicentric Castleman disease (MCD) characterized by multicentric lymphadenopathy and polyclonal hyperimmunoglobulinemia. Steroid therapy (prednisolone, 20 mg/day) was effective in reducing the symptoms, the bilateral eyelid tumors and the swelling of the bilateral submandibular glands and superficial lymph nodes. The lack of any increase of serum IL-6 suggested that this case had a hitherto unknown etiology, other than MCD.

    DOI: 10.11406/rinketsu.48.229

    CiNii Article

  • Thiopurine S-methyltransferase gene polymorphism in Japanese patients with autoimmune liver diseases Reviewed

    Tamori Akihiro, Shinzaki Mayumi, Kosaka Saori, Hayashi Takehiro, Iwai Shuji, Enomoto Masaru, Habu Daiki, Sakaguchi Hiroki, Kawada Norifumi, Hino Masayuki, Shiomi Susumu, Nishiguchi Shuhei

    LIVER INTERNATIONAL   27 ( 1 )   95 - 100   2007.02( ISSN:1478-3223

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    DOI: 10.1111/j.1478-3231.2006.01392.x

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  • 妊娠により重症化した難治性特発性血小板減少性紫斑病に対して摘脾が有効であった1例 Reviewed

    市原 弘善, 山根 孝久, 康 秀男, 中根 孝彦, 武岡 康信, 坂本 恵利奈, 金島 広, 中前 博久, 高 起良, 山田 靖哉, 松本 万紀子, 橘 大介, 石河 修, 日野 雅之

    血液診療   4 ( 2 )   46 - 48   2007.02

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    36歳女。めまいを主訴に近医を受診し、特発性血小板減少性紫斑病(ITP)と診断された。出血症状は認められず、無治療で経過観察していた。妊娠第10週第3日の受診時、血小板数は5.9万であったが、次第に減少し、減少傾向を認めた。ステロイドおよびH.pylori除菌療法を施行したが無効であった。本人および配偶者が妊娠の継続・出産を希望し、ガンマグロブリン大量療法で血小板数を増加させた後に摘脾を行うこととなった。妊娠38週2日目に経腟分娩にて健児を得ることができた。

  • Two cases of ampulla (takotsubo-shaped) cardiomyopathy associated with hemophagocytic lymphohistiocytosis Reviewed

    Takeoka Yasunobu, Nakamae Mika, Nakamae Hirohisa, Hagihara Kiyoyuki, Sakamoto Erina, Nakane Takahiko, Koh Hideo, Koh Ki-Ryang, Ohta Kensuke, Yamane Takahisa, Hino Masayuki

    ACTA HAEMATOLOGICA   117 ( 4 )   205 - 210   2007( ISSN:0001-5792

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    DOI: 10.1159/000098461

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  • Long-term survival after HLA-haploidentical stem cell transplantation, from non-inherited maternal antigen-mismatched family donors: Impact of chronic graft-versus-host disease

    Ichinohe, Tatsuo, Shimazaki, Chihiro, Hamaguchi, Motohiro, Watanabe, Arata, Ishida, Hiroyuki, Yoshihara, Takao, Morimoto, Akira, Uoshima, Nobuhiko, Adachi, Souichi, Inukai, Takeshi, Sawada, Akihisa, Oka, Koji, Itoh, Mitsuru, Hino, Masayuki, Kanda, Junya, Uchiyama, Takashi, Kodera, Yoshihisa

    BLOOD   110 ( 11 )   349B - 349B   2007( ISSN:0006-4971

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  • Myelodysplastic syndrome with cyclosporine A-induced encephalopathy presenting with a mass effect on the right basal ganglia after cord blood transplantation Reviewed

    KOH Hideo, YAMANE Takahisa, NAKANE Takahiko, TAKEOKA Yasunobu, SAKAMOTO Erina, KANASHIMA Hiroshi, NAKAMAE Mika, NAKAMAE Hirohisa, KOH Ki-ryang, MOCHIZUKI Kunizo, HAYASHI Noriko, HINO Masayuki

    The Japanese Society of Hematology, Rinsho Ketsueki   47 ( 12 )   1539 - 1543   2006.12( ISSN:04851439

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    An 18-year-old female with myelodysplastic syndrome underwent an allogeneic cord blood transplantation in May 2005. The conditioning regimen consisted of total body irradiation, cytarabine and cyclophosphamide. The day of the cord stem cell transfusion was counted as Day 0. For acute GVHD prophylaxis, cyclosporine A (CsA) and methotrexate were used. Engraftment was achieved on Day 30, acute GVHD grade II developed on Day 45 and treatment with methylprednisolone for acute GVHD was started. On Day 68 the patient had generalized seizures accompanied by loss of consciousness, hypertension and left hemiparesis, and was intubated. A cranial CT scan showed a mass effect on the right basal ganglia, and high signal intensities on the T2-weighted and FLAIR images of a MR examination were detected in the bilateral basal ganglia and posterior lobes, the findings of which were compatible with a brain tumor or infectious disease. Since an increased level of apparent diffusion coefficient (ADC) values on the bilateral basal ganglia was noted, we suspected that vasogenic edema had caused the mass effect. She went into remission immediately after CsA treatment was discontinued. Therefore, this case was diagnosed as atypical reversible posterior leukoencephalopathy syndrome (RPLS) associated with CsA. CsA-induced encephalopathy presenting a mass effect in clinical imaging findings is very rare, and an ADC map may be useful for the diagnosis of RPLS.

    DOI: 10.11406/rinketsu.47.1539

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  • Rituximab provided long-term remission in a patient with severe thrombotic thrombocytopenic purpura refractory to plasma exchange Reviewed

    HONG Hyunsoo, AOYAMA Yasutaka, YAMAMURA Ryousuke, OHTA Tadanobu, MUGITANI Atsuko, YAMANE Takahisa, HINO Masayuki, MATSUMOTO Masanori, FUJIMURA Yoshihiro

    The Japanese Society of Hematology, Rinsho Ketsueki   47 ( 12 )   1528 - 1532   2006.12( ISSN:04851439

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    We report a patient with severe thrombotic thrombocytopenic purpura (TTP) refractory to plasmapheresis who was successfully treated with rituximab. A 57-year-old male patient was referred to our department for further differential diagnosis and treatment of anemia and severe thrombocytopenia. Progressive psychoneurotic symptoms, hemolytic anemia, thrombocytopenia, renal function insufficiency and fever led us to the diagnosis of TTP. ADAMTS13 activity was below 3% and an inhibitor for ADAMTS13 was detected. Treatment with plasmapheresis and high-dose steroid was initiated but without clinical benefit. Two weeks following the initiation of plasmapheresis, we decided to treat the patient with 7 cycles of rituximab. No severe rituximab-related adverse effects were observed. After treatment with rituximab, the disease remitted, and the ADAMTS13 activity level increased. The patient has remained in complete remission for more than 1 year. Our data suggest that rituximab may be the optimal immunosuppressive therapy for refractory thrombotic thrombocytopenic purpura caused by an anti-ADAMTS 13 inhibitor.

    DOI: 10.11406/rinketsu.47.1528

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  • Infusions of fresh frozen plasma to the patients with a high-risk group for hepatic VOD associated with stem cell transplantation reduce its occurrence. Reviewed

    Matsumoto Masanori, Kawa Keisei, Yagi Hieo, Park Yong-Dong, Takeshima Yasuhiro, Kosaka Yoshiyuki, Hara Hiroshi, Kai Shunro, Yamamoto Masuii, Kanemaru Akihisa, Fukuhara Shirou, Hino Masayuki, Sako Masahiko, Hiraoka Akira, Ogawa Hiroyasu, Hara Junichi, Fujimura Yoshihiro

    BLOOD   108 ( 11 )   433A   2006.11( ISSN:0006-4971

  • Enhanced neutrophil motility by granulocyte colony-stimulating factor: the role of extracellular signal-regulated kinase and phosphatidylinositol 3-kinase Reviewed

    Nakamae-Akahori Mika, Kato Takayuki, Masuda Sayuri, Sakamoto Erina, Kutsuna Haruo, Hato Fumihiko, Nishizawa Yoshiki, Hino Masayuki, Kitagawa Seiichi

    IMMUNOLOGY   119 ( 3 )   393 - 403   2006.11( ISSN:0019-2805

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    顆粒球コロニー刺激因子(G-CSF)のヒト好中球の運動性への影響を、ビデオ顕微鏡にて検討。 G-CSFによる好中球刺激は、形態学的変化を伴う運動促進と接着性の増加をもたらした。好中球の運動促進は、G-CSF刺激後3〜5分以内に検出され、10分で最大に達し、約35分間持続した。最大遊走率は84.4 +/- 2.9 microm / 5分。ボイデンチャンバー法を用いて、G-CSF刺激好中球は走化ではなくランダム遊走であることが明らかになった。好中球の運動性と形態変化の増強は、MEK阻害剤およびPI3K阻害剤によって阻害され、p38 MAPK阻害では阻害されなかった。これらは、G-CSFが好中球のMEK / ERKとPI3Kを選択的に活性化するが、p38は活性化しないという事実と一致。 MEK / ERKの活性化は、G-CSFによるF-アクチンおよびリン酸化ミオシン軽鎖の再分布と関連があった。好中球の運動促進は、細胞接着を妨げる中和抗CD18抗体の存在下でも観察された。これらは、G-CSFがMEK / ERKおよびPI3Kの活性化を介してヒト好中球の遊走を誘導することを示す。

    DOI: 10.1111/j.1365-2567.2006.02448.x

    PubMed

  • Mast cells in diffuse large B-cell lymphoma; their role in fibrosis Reviewed

    Fukushima H., Ohsawa M., Ikura Y., Naruko T., Sugama Y., Suekane T., Kitabayashi C., Inoue T., Hino M., Ueda M.

    HISTOPATHOLOGY   49 ( 5 )   498 - 505   2006.11( ISSN:0309-0167

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    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

    DOI: 10.1111/j.1365-2559.2006.02534.x

  • Expression of cyclooxygenase-2 in Hodgkin's lymphoma: Its role in cell proliferation and angiogenesis Reviewed

    Ohsawa Masahiko, Fukushima Hiroko, Ikura Yoshihiro, Inoue Takeshi, Shirai Nobuyuki, Sugama Yoshimi, Suekane Takehisa, Kitabayashi Chizuko, Nakamae Hirohisa, Hino Masayuki, Ueda Makiko

    LEUKEMIA & LYMPHOMA   47 ( 9 )   1863 - 1871   2006.09( ISSN:1042-8194

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    DOI: 10.1080/10428190600685442

    PubMed

  • Platelet activation is associated with hypoadiponectinemia and carotid atherosclerosis Reviewed

    Shoji Takuhito, Koyama Hidenori, Fukumoto Shinya, Maeno Takaaki, Yokoyama Hisayo, Shinohara Kayo, Emoto Masanori, Shoji Tetsuo, Yamane Takahisa, Hino Masayuki, Shioi Atsushi, Nishizawa Yoshiki

    ATHEROSCLEROSIS   188 ( 1 )   190 - 195   2006.09( ISSN:0021-9150

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    DOI: 10.1016/j.atherosclerosis.2005.10.034

    PubMed

  • 疾患と検査値の推移 骨髄移植(造血幹細胞移植)と検査値

    日野 雅之

    検査と技術   34 ( 8 )   747 - 754   2006.08( ISSN:03012611

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  • Risk factor analysis for thrombotic microangiopathy after reduced-intensity or myeloablative allogeneic hematopoietic stem cell transplantation Reviewed

    Nakamae H, Yamane T, Hasegawa T, Nakamae M, Terada Y, Hagihara K, Ohta K, Hino M

    AMERICAN JOURNAL OF HEMATOLOGY   81 ( 7 )   525 - 531   2006.07( ISSN:0361-8609

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    DOI: 10.1002/ajh.20648

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  • T-lymphocyte subset analysis using the automated hematology analyser CELL-DYN 4000 for patients with hematological disorders Reviewed

    T Yamane, K Hagihara, H Nakamae, T Hasegawa, M Hino

    TAYLOR & FRANCIS LTD LEUKEMIA & LYMPHOMA   47 ( 3 )   503 - 506   2006.03( ISSN:1042-8194

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    We evaluated the performance of a fully-automated hematology analyser CELL-DYN 4000 (CD4000; Abbott Laboratories, CA, USA) for T-lymphocyte subset analysis using the samples from 58 patients with hematological disorders. A flow cytometer (CytoronAbsolute; Ortho Diagnostics, NJ, USA) was used for comparison. Good correlations were shown between CD4000 and CytoronAbsolute for the of CD3+, CD4+, and CD8+ T-lymphocyte counts (for each of correlations, r=0.992, 0.992, and 0.969, respectively). This good correlation was sustained even in 24 cases in which the CD4+T-lymphocyte counts were less than 200/mu l. In this group the correlation coefficients (r-values) for the comparisons between CD3+, CD4+, and CD8+T-lymphocytes measured by CD4000 and CytoronAbsolute were 0.991, 0.976, and 0.990, respectively. The CD4000 T-lymphocyte assay is a completely automated method, and does not require opening of the sample tube, which reduces exposure to any biohazards such as HIV. Furthermore, the method is rapid and requires only 7 min for completion of the analysis.

    DOI: 10.1080/10428190500353612

  • non-Hodgkin's lymphomaに対する地固め療法としての自家末梢血幹細胞移植併用大量化学療法 -第2報- Reviewed

    山根孝久、廣瀬朝生、中嶋康博、中根孝彦、康 秀男、武岡康信、中前美佳、山村亮介、中前博久、中尾吉孝、麥谷安津子、屋木敏也、手島博文、日野雅之

    癌と化学療法   33 ( 2 )   193 - 198   2006.02( ISSN:0385-0684

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  • Expression of cyclooxygenase-2 in Hodgkin's lymphoma: its role in cell proliferation and angiogenesis. Reviewed

    Leukemia and Lymphoma   47 ( 9 )   1863 - 1871   2006

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  • T-lymphocyte subset analysis using the automated hematology analyser CELL-DYN 4000 for patients with hematological disorders. Reviewed

    Leukemia and Lymphoma   47 ( 3 )   503 - 506   2006

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  • Notable effects of angiotensin II receptor blocker, valsartan, on acute cardiotoxic changes after standard chemotherapy with cyclophosphamide, doxorubicin, vincristine, and prednisolone Reviewed

    Nakamae H, Tsumura K, Terada Y, Nakane T, Nakamae M, Ohta K, Yamane T, Hino M

    CANCER   104 ( 11 )   2492 - 2498   2005.12( ISSN:0008-543X

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    DOI: 10.1002/cncr.21478

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  • Cord blood transplantation for adult patients with hematological malignancies. Reviewed

    Yamane T, Nakamae H, Hasegawa T, Terada Y, Hagihara K, Ohta K, Hino M

    Osaka city medical journal   51 ( 2 )   83 - 88   2005.12( ISSN:0030-6096

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    PubMed

  • Evaluation of an automated hematologyanalyzer (CELL-DYN 4000) for counting CD4+ T helper cells at low concentrations. Reviewed

    Hagihara K, Yamane T, Aoyama Y, Nakamae H, Hino M

    Annals of clinical and laboratory science   35 ( 1 )   31 - 6   2005.12( ISSN:0091-7370

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    In human immunodeficiency virus (HIV) infection, CD4 cell counts are useful in defining the disease state, monitoring antiviral treatment, and identifying patients at risk for opportunistic infections. Counting CD4 cells typically relies on traditional immuno-flow cytometric analyzers that require opening the tube for manipulation of the blood sample. In addition to automated blood cell counting, the CELL-DYN 4000 hematology analyzer performs a completely enclosed and automated analysis of the T lymphocyte subsets. We studied the performance characteristics of this method in blood samples containing low levels of CD4+ T cells. In one set of experiments, we emulated low level CD4 counts by use of a CD4 Positive Isolation Kit to deplete the CD4+ cells from blood samples. We used the FACScan analyzer for reference counts. Measurements were made exactly 12 hr after venepuncture in samples that were stored at room temperature. In normal samples and those with low CD4+ cell counts, there was excellent correlation between the results of the CELL-DYN and FACScan methods. Using the CELL-DYN 4000 analyzer, the precision of CD4+ and CD8+ T-cell counts was high (CV = 2 to 8%). The CD4+ T-cell count was linear over a wide range (35 to 1640 cells/μl). This study shows that CD4 and CD8T cell counts using the CELL-DYN 4000 analyzer is suitable for normal samples and also for those with low CD4+ T cell counts. The method is rapid and automated, and blood specimens remain enclosed, minimizing the biohazard of exposure to blood of HIV patients. © 2005 by the Association of Clinical Scientists, Inc.

    PubMed

  • [Autologous hematopoietic stem cell transplantation for aggressive B-cell non-Hodgkin's lymphoma].

    Hirose A, Yamane T, Nakajima Y, Manabe M, Kanashima H, Hagihara K, Sakamoto E, Nakamae M, Terada Y, Kosaka S, Aoyama Y, Sakamoto C, Kumura T, Koh KR, Hirai M, Ohta K, Nakao Y, Mugitani A, Teshima H, Hino M

    Gan to kagaku ryoho. Cancer & chemotherapy   32 ( 13 )   2059 - 64   2005.12( ISSN:0385-0684

  • Chronic GVHD with polymyositis after non-myeloablative stem cell transplantation Reviewed

    NAKAMAE Hirohisa, HIMURO Kimihide, HAGIHARA Kiyoyuki, TERADA Yoshiki, SAKAMOTO Erina, TAKEOKA Yasunobu, NAKANE Takahiko, NAKAMAE Mika, OHTA Kensuke, YAMANE Takahisa, SHIMADA Hiroyuki, MIKI Takami, HINO Masayuki

    The Japanese Society of Hematology, Rinsho Ketsueki   46 ( 11 )   1213 - 1217   2005.11( ISSN:04851439

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    A 57-year-old man underwent an autologous hematopoietic stem cell transplant for mantle cell lymphoma in August 1999. Anemia and thrombocytopenia appeared in November 2001. He was diagnosed with further hematological examination as having acute myeloid leukemia with multilineage dysplasia following secondary myelodysplastic syndrome. He received the allogeneic hematopoietic stem cell transplant from his HLA DRB1 locus mismatched brother in May 2002. The non-myeloablative preparative regimen consisted of fludarabine 30mg/m<sup>2</sup> for 6 days and busulfan 4mg/kg for 2 days. Eosinophilia, decrease of lacrimal fluid and liver dysfunction appeared on Day 104. We diagnosed this as chronic GVHD and treated the patient with prednisolone 10 mg/day. Thereafter, his chronic GVHD gradually improved. He had fever and myalgia in the extremities and lumbar region with elevated serum CPK and aldolase in January 2003. Histological examination led to a diagnosis of polymyositis simultaneously with chronic GVHD. Prednisolone 50 mg/day as an initial dose was started for the polymyositis following which the prednisolone dose was gradually tapered off. The polymyositis improved promptly after the administration of prednisolone and remains in remission with a current maintenance program of prednisolone 5 mg/day.

    DOI: 10.11406/rinketsu.46.1213

    CiNii Article

  • Prognostic significance of BACH2 expression in diffuse large B-cell lymphoma: a study of the Osaka Lymphoma Study Group. Reviewed

    Sakane-Ishikawa E, Nakatsuka S, Tomita Y, Fujita S, Nakamichi I, Takakuwa T, Sugiyama H, Fukuhara S, Hino M, Kanamaru A, Soma T, Tsukaguchi M, Igarashi K, Kanakura Y, Aozasa K, Osaka Lymphoma Study Group.

    Journal of clinical oncology   23 ( 31 )   8012 - 8017   2005.11( ISSN:0732-183X

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    DOI: 10.1200/JCO.2005.02.1626

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  • L-Asparaginaseが一時的に有効であったNasal NK/T-Cell Lymphoma Reviewed

    坂本 恵利奈, 山根 孝久, 中根 孝彦, 武岡 康信, 廣瀬 朝生, 萩原 潔通, 中前 博久, 太田 健介, 平山 道彦, 伊倉 義弘, 大澤 政彦, 澤田 達, 鬼頭 敏幸, 日野 雅之

    癌と化学療法   32 ( 12 )   1993 - 1996   2005.11( ISSN:0385-0684

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    症例は48歳,男性。鼻腔内生検にてnasal NK/T-cell lymphomaと診断、CHOP療法、放射線照射+DeVIC療法が無効であった。腫瘍パラフィン標本のasparagine synthetase免疫染色が弱陽性であったことより,L-asparaginase投与を2コース行ったところ,症状改善とおよび腫瘍の縮小を認めたが、その後、増悪し永眠された。剖検では,血球貪食症候群および原疾患の多臓器への浸潤を認めた。

    PubMed

  • Detection of various platelet-associated immunoglobulins by flow cytometry in idiopathic thrombocytopenic purpura Reviewed

    Nishioka T, Yamane T, Takubo T, Ohta K, Park K, Hino M

    CYTOMETRY PART B-CLINICAL CYTOMETRY   68B ( 1 )   37 - 42   2005.11( ISSN:1552-4949

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    DOI: 10.1002/cyto.b.20067

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  • 発熱性好中球減少症に対する抗菌薬治療の臨床解析 Reviewed

    柴田仙子、山根孝久、坂本恵利奈、中前博久、太田健介、日野雅之

    The Japanese journal of antibiotics   58 ( 4 )   382 - 387   2005.08( ISSN:0368-2781

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    発熱性好中球減少症に対する抗菌薬の有効性をretrospectiveに検討した。単変量解析にて、カルバペネム系抗菌薬使用群および投与終了時の好中球数が500/μL以上の群で有意に有効であった。多変量解析ではカルバペネム系抗菌薬使用群は投与終了時の好中球数に関わらず、セフェム系薬剤使用群より有意に有効であった。

    PubMed

  • Type I and type II interferons delay human neutrophil apoptosis via activation of STAT3 and up-regulation of cellular inhibitor of apoptosis 2 Reviewed

    Sakamoto E, Hato F, Kato T, Sakamoto C, Akahori M, Hino M, Kitagawa S

    JOURNAL OF LEUKOCYTE BIOLOGY   78 ( 1 )   301 - 309   2005.07( ISSN:0741-5400

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    DOI: 10.1189/jlb.1104690

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  • Immunohistochmeical expression of multidrug resistance proteins as a predictor of poor response to chemotherapy and prognosis in patients with nodal diffuse large B-cell lymphoma. Reviewed

    Oncology   68 ( 4-6 )   422 - 431   2005.06

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  • Reduced-intensity stem-cell transplantation for adult acute lymphoblastic leukemia: a retrospective study of 33 patients Reviewed

    Hamaki T, Kami M, Kanda Y, Yuji K, Inamoto Y, Kishi Y, Nakai K, Nakayama I, Murashige N, Abe Y, Ueda Y, Hino M, Inoue T, Ago H, Hidaka M, Hayashi T, Yamane T, Uoshima N, Miyakoshi S, Taniguchi S

    BONE MARROW TRANSPLANTATION   35 ( 6 )   549 - 556   2005.03( ISSN:0268-3369

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    DOI: 10.1038/sj.bmt.1704776

  • 非ステロイド系消炎鎮痛剤による多発性下部消化管潰瘍を合併した急性骨髄単球性白血病 Reviewed

    洪 鉉寿, 山根 孝久, 青山 泰孝, 阪本 親彦, 中前 博久, 長谷川 太郎, 寺田 芳樹, 日野 雅之

    癌と化学療法   32 ( 1 )   111 - 113   2005.01( ISSN:0385-0684

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    症例は急性骨髄単球性白血病の19歳、女性。寛解導入療法中に多量の下血がみられた、下部消化管内視鏡で類円形の多発性潰瘍を認め、組織像では非特異的炎症像ならびにアポトーシス体が散在性にみられた。患者は長引く発熱,咽頭痛で非ステロイド系消炎鎮痛剤(NSAID)を連日服用していたことから、NSAIDによって生じた下部消化管潰瘍からの下血と診断した。NSAIDを中止し,いったん止血したが、再び下血し、塞栓術を試みたが,不十分で、内視鏡的クリッピング術ならびにバゾプレッシンの持続投与を行い、止血,全身状態は改善した。

    PubMed

  • 膀胱原発Mucosa-associated lymphoid tissue(MALT)リンパ腫の1例 Reviewed

    高原 由姫, 川嶋 秀紀, 韓 榮新, 杉村 一誠, 仲谷 達也, 田中 一巨, 日野 雅之

    泌尿器科紀要   51 ( 1 )   45 - 48   2005.01( ISSN:0018-1994

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  • Automated analyzer evaluation of reticulocytes in bone marrow and peripheral blood of hematologic disorders Reviewed

    Hirose A, Yamane T, Shibata H, Kamitani T, Hino M

    ACTA HAEMATOLOGICA   114 ( 3 )   141 - 145   2005( ISSN:0001-5792

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    R-3000網赤血球解析装置を使用して、血液疾患111人の骨髄(BM)および末梢血(PB)119サンプルを解析。BMの網状赤血球と未熟網赤血球分画(IRF)の割合は、PBよりも高く、BMとPBの網状赤血球割合の相関は良好だった。貧血群のうち無効造血(骨髄異形成症候群)群のBM / PB網状赤血球比は、それ以外の貧血群よりも統計的に高く、骨髄異形成症候群の診断の有用な指標であることを示している。

    DOI: 10.1159/000087887

    PubMed

  • Cord blood transplantation for adult patients with hematological malignancies. Reviewed

    Osaka City Medical Journal   51 ( 2 )   83 - 88   2005

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  • Evaluation of noninvasive hemoglobin monitoring for hematological disorders. Reviewed

    J Clin Lab Anal.   19 ( 1 )   1 - 5   2005

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  • Evaluation of an automated hematologyanalyzer (CELL-DYN 4000) for counting CD4+ T helper cells at low concentrations. Reviewed

    Ann Clin Lab Sci   35 ( 1 )   31 - 36   2005

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  • Study of the Sampling Method of Blood Samples for Total-Reflection X-ray Fluorescence(<Special Articles>The First Papers of Prospective Analytical Chemists) Reviewed

    MATSUOKA Yoshiko, HOSOKAWA Yoshinori, HINO Masayuki, TSUJI Kouichi

    The Japan Society for Analytical Chemistry, BUNSEKI KAGAKU   54 ( 9 )   749 - 753   2005( ISSN:0525-1931

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    We investigated the sampling method of blood samples for total-reflection x-ray fluorescence (TXRF) analysis. Three types of samples, such as whole blood, serum and blood plasma, were prepared. After these samples were diluted by Milli-Q water, they were allowed to fall in drops onto an acrylic flat substrate, which was used as a sample carrier for TXRF analysis. In the case of a whole blood sample, the detection limits of Fe and Cl were improved by adding Milli-Q water to the sample. We consider that the improvement of the detection limits resulted from destruction of the red blood cells. This suggests that whole blood diluted by Milli-Q water is a suitable sample-preparation method for TXRF analysis without a time-consuming procedure.

    DOI: 10.2116/bunsekikagaku.54.749

    CiNii Article

  • Immunohistochemical expression of multidrug resistance proteins as a predictor of poor response to chemotherapy and prognosis in patients with nodal diffuse large B-cell lymphoma Reviewed

    M Ohsawa, Y Ikura, H Fukushima, N Shirai, Y Sugama, T Suekane, M Hirayama, M Hino, M Ueda

    KARGER ONCOLOGY   68 ( 4-6 )   422 - 431   2005( ISSN:0030-2414

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    Background/Aims: The aim of this study was to determine whether expression of P-glycoprotein (P-gp), multidrug-resistance-related protein 1 (MRP1), and lung resistance protein (LRP) was related to the response to induction chemotherapy and prognosis in untreated diffuse large B-cell lymphoma (DLBCL). Methods: We assessed immunohistochemical expression of P-gp, MRP1 and LRP, using formalin-fixed and paraffin-embedded specimens of lymph node in 41 patients with DLBCL. Association between expression of these three proteins and their impact on clinical outcome and prognosis was statistically evaluated. Results: P-gp was positive in 37% of subjects, MRP1 in 63%, and LRP in 68%. The complete remission rates achieved in the group expressing these multidrug resistance (MDR) proteins was significantly lower than in the group not expressing them (20 versus 58%; p = 0.025 in P-gp, 23 versus 80%; p &lt; 0.001 in MRP1 and 32 versus 69%, p = 0.043 in LRP, respectively). Furthermore, the patients expressing LRP had a shorter overall survival rate than those that did not (median of 26 months versus median not reached; p = 0.013). Conclusions:These findings suggest that the three MDR proteins are important predictive factors for the clinical outcome and prognosis in patients with DLBCL. Copyright (C) 2005 S. Karger AG, Basel.

    DOI: 10.1159/000086984

  • Automated analysis of bone marrow reticulocytes using the XE-2100 automated hematology analyzer. Reviewed

    Acta Haematol.   111 ( 4 )   237 - 238   2004

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  • A case of a long-time survivor with chronic active Epstein-Barr virus infection. Reviewed

    Eur J Haematol   72 ( 1 )   73 - 76   2004

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  • Selective activation of STAT3 in human monocytes stimulated by G-CSF: implication in inhibition of LPS-induced TNF-alpha production. Reviewed

    Am J Physiol Cell Physiol   286 ( 6 )   302 - 311   2004

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  • Pericarditis associated with Epstein-Barr virus reactivation in a patient following allogeneic peripheral blood stem cell transplantation from an HLA genotypic 1-locus mismatched sibling donor. Reviewed

    Leuk Lymphoma   45 ( 2 )   393 - 395   2004

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  • Adefovir dipivoxil to prevent exacerbation of lamivudine-resistant hepatitis B infection during chemotherapy for non-Hodgkin's lymphoma. Reviewed

    Am J Gastroenterol   99 ( 8 )   1619 - 1620   2004

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  • QT dispersion correlates with systolic rather than diastolic parameters in patients receiving anthracycline treatment. Reviewed

    Intern Med   43 ( 5 )   379 - 387   2004

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  • Feasibility of HLA-haploidentical hematopoietic stem cell transplantation between noninherited maternal antigen (NIMA)-mismatched family members linked with long-term fetomaternal microchimerism. Reviewed

    Blood   104 ( 12 )   3821 - 3828   2004

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  • Conditioning regimens including high-dose busulfan cause a high incidence of transplant-related mortality after myeloablative stem cell transplantation. Reviewed

    Chemotherapy.   50 ( 4 )   178 - 183   2004

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  • Acute myelogenous leukemia in a donor after granulocyte colony-stimulating factor primed peripheral blood stem cell harvest Reviewed

    Bone Marrow Transplantation   33 ( 6 )   661 - 668   2004

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  • Predictive values of QT disoersion for acute heart failure after autologous and allogeneic hematopoietic stem cell transplantation Reviewed

    American Journal of Hematology   76 ( 1 )   1 - 7   2004

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  • Electrocardiogram is very useful for predicting acute heart failure following myeloablative chemotherapy with hematopoietic stem cell transplantation rescue. Reviewed

    Bone Marrow Transplantation   31 ( 7 )   585 - 590   2003.04

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  • Platelet recovery after eradication of Helicobacter pylori in patients with idiopathic thrombocytopenic purpura. Reviewed

    Annals of Hematology   82 ( 1 )   30 - 32   2003.01

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  • Antiapoptotic effect of granulocyte colony-stimulating factor, granulocyte-macrophage colony-stimulating factor, and cyclic AMP on human neutrophils: protein synthesis-dependent and protein synthesis-independent mechanisms and the role of the Janus kinase-STAT pathway. Reviewed

    International Journal of Hematology   77 ( 1 )   60 - 70   2003

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  • Expression of the inhibitor of apoptosis (IAP) family members in human neutrophils: up-regulation of cIAP2 by granulocyte colony-stimulating factor and overexpression of cIAP2 in chronic neutrophilic leukemia. Reviewed

    Blood   101 ( 3 )   1164 - 1171   2003

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  • Infliximab for the treatment of severe steroid refractory acute graft-versus-host disease in three patients after allogeneic hematopoietic transplantation. Reviewed

    Leuk Lymphoma   44 ( 12 )   2095 - 2097   2003

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  • Excretion of granulocyte colony-stimulating factor into human breast milk. Reviewed

    Acta Haematol   110 ( 4 )   200 - 201   2003

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  • Reduced-intensity stem cell transplantation in two cases of metastatic renal cell carcinoma. Reviewed

    Int J Urol   10 ( 11 )   610 - 614   2003

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  • Thrombopoietin stimulates ex vivo expansion of mature neutrophils in the early stages of differentiation. Reviewed

    Ann Hematol.   82 ( 11 )   671 - 676   2003

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  • Esophageal actinomycosis after allogeneic peripheral blood stem cell transplantation for extranodal natural killer/T cell lymphoma, nasal type. Reviewed

    Bone Marrow Transplant   32 ( 4 )   451 - 453   2003

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  • Automatic analysis of normal bone marrow blood cells using the XE-2100 automated hematology analyzer. Reviewed

    J Clin Lab Anal   17 ( 1 )   12 - 17   2003

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  • Development of chronic myelocytic leukemia after chemotherapy for malignant fibrous histiocytoma. Reviewed

    Acta haematologica   109 ( 3 )   141 - 144   2003

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  • Successful treatment with reduced-intensity stem cell transplantation in a case of relapsed refractory central nervous system lymphoma. Reviewed

    Annals of Hematology   82 ( 6 )   371 - 373   2003

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  • Platelet P-selectin expression is associated with atherosclerotic wall thickness in carotid artery in humans. Reviewed

    Circulation   108 ( 5 )   524 - 529   2003

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  • Differential effects of fibroblast growth factor-4, epidermal growth factor and transforming growth factor-beta1 on functional development of stromal layers in acute myeloid leukemia. Reviewed

    Leuk Res   26 ( 10 )   933 - 938   2002.10

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  • Role of mitogen-activated protein kinase family in serum-induced leukaemia inhibitory factor and interleukin-6 secretion by bone marrow stromal cells. Reviewed

    Br J Pharmacol   136 ( 7 )   975 - 984   2002.04

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  • Simple high-density lipoprotein cholesterol assay based on dry chemistry. Reviewed

    Clin Chim Acta   320 ( 1-2 )   79 - 88   2002

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  • Measurement of Hemoglobin Concentrations Using the Astrim(TM) Noninvasive Blood Vessel Monitoring Apparatus. Reviewed

    Acta Haematol   108 ( 2 )   109 - 110   2002

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  • The HLA-DOB gene displays limited polymorphism with only one amino acid substitution. Reviewed

    Tissue Antigens   59 ( 6 )   512 - 519   2002

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  • New compact-type latex photometric immunoassay system for hemoglobin and three acute inflammation markers: neutrophil count, C-reactive protein, and anti-streptolysin O Reviewed

    J Clin Lab Anal   16 ( 2 )   95 - 102   2002

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  • A novel cell surface antigen, 4C8 is expressed on human eosinophils Reviewed

    Cytometoly   50 ( 1 )   8 - 13   2002

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  • Clinical significance of serum soluble transferrin receptor levels in haematologic malignancies Reviewed

    J Tumor Marker Oncol   17   13 - 15   2002

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  • Clinical usefulness of serum IL-18 level determination in patients with haematologic malignancies

    J Tumor Marker Oncol   17   25 - 27   2002

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  • 造血器悪性疾患に対する骨髄非破壊的造血幹細胞移植

    山根孝久、青山泰孝、中前博久、山村亮介、島 悦子、牧田香理、田中一巨、太田健介、 巽 典之、日野雅之

    Biotherapy   16   165 - 170   2002

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  • Possible automatic cell classification of bone marrow aspirate using the CELL-DYN 4000 automatic blood cell analyzer.

    J Clin Lab Analysis   16   86 - 90   2002

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  • Selective activation of p38 mitogen-activated protein kinase cascade in human neutrophils stimulated by IL-1β. Reviewed

    J Immunol   167 ( 10 )   5940 - 5947   2001.11

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  • Apoptosis and thymidylate synthase inductions by 5-fluorouracil in gastric cancer cells with or without p53 mutation. Reviewed

    Int J Oncol   19 ( 2 )   373 - 378   2001.08

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  • RNA extraction from ethanol-fixed leukocytes trapped on polyethylene terephthalate filter for RT-PCR analysis. Reviewed

    Biotech   30 ( 5 )   954 - 960   2001.05

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  • Cleavage of mitogen-activated protein kinases in human neutrophils undergoing apoptosis: role in decreased responsiveness to inflammatory cytokines. Reviewed

    J Immunol   166 ( 2 )   1185 - 1192   2001.01

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  • Serum KL-6 levels in haematologic malignancies and their clinical application. Reviewed

    Haematologia   31 ( 1 )   61 - 67   2001

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  • Expression of human interleukin-18 antigen in leukemia cells in a patient with acute mixed lineage leukemia. Reviewed

    Haematologia   31 ( 1 )   69 - 71   2001

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  • Elevation of serum procalcitonin level in a patient with chronic myelocytic leukemia. Reviewed

    Haematologia   31 ( 2 )   177 - 179   2001

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  • Expression of KL-6 antigen on leukemia cells of a patient with chronic myelocytic leukemia in blastic phase. Reviewed

    Haematologia   31 ( 1 )   173 - 176   2001

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  • HLA class II alleles in Japanese patients with non-Hodgkin"s lymphoma. Reviewed

    Southeast Asian J Trop Med Public Health   31 ( 3 )   556 - 560   2000.09

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  • Ex vivo expansion of mature human neutrophils with normal functions from purified peripheral blood CD34+ haematopoietic progenitor cells. Reviewed

    Br J Haematol   109 ( 2 )   314 - 321   2000.05

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  • DX-9065a, a specific factor Xa inhibitor, as a universal anticoagulant for blood collection tubes. Reviewed

    Clin Chim Acta   294 ( 1-2 )   27 - 35   2000.04

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  • QT dispersion as a predictor of acute heart failure after high-dose cyclophosphamide. Reviewed

    Lancet   355 ( 4 )   805 - 806   2000.03

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  • Transmission of symptomatic parvovirus B19 infection by fibrin sealant during surgery. Reviewed

    Br J Haematol   108 ( 1 )   194 - 195   2000.01

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  • Systhetic polymer sulphonated polyisoprene as a universal anticoagulant for laboratory testing. Reviewed

    J. Clin. Lab. Anal.   14 ( 4 )   180 - 187   2000

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  • Argatroban as an anticoagulant for both hematologic and chemical tests. Reviewed

    J. Clin. Lab. Anal.   14 ( 4 )   136 - 140   2000

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  • A practical quick staining method using by hydrochloric acid-fast metachromatic dye for megakaryocytes. Reviewed

    Haematologia   30 ( 1 )   11 - 21   2000

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  • Lymphoma in Castleman"s disease, acute lymphocytic leukemia, adult T-cell leukemia, cutaneous T-cell lymphoma accompanied with high serum soluble Fas ligand levels. Reviewed

    Haematologia   30 ( 1 )   23 - 26   2000

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  • Neutropenia accompanying parvovirus B19 infection after gynecologic surgery Reviewed

    Acta Haematol.   103 ( 4 )   186 - 190   2000

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  • New enzymatic method for determing D-arabinitol in serum. Reviewed

    J Basic Miclobiol   40 ( 5-6 )   363 - 368   2000

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  • 当科における急性白血病に対する造血幹細胞移植の臨床的検討 Reviewed

    山根孝久、日野雅之、太田健介、高 起良、太田忠信、青山泰孝、阪本親彦、中前博久、長谷川太郎、山村亮介、岸田卓也、田窪孝行、巽 典之

    大阪市医学会雑誌   49   191 - 199   2000

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  • Analogues of ethylenediaminetetraacetic acid and sodium fluoride as anticoagulants. Reviewed

    Osaka City Med J   46 ( 1 )   71 - 76   2000

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  • Low-molecular-weight heparin as a multipurpose anticoagulant for laboratory testing. Reviewed

    Osaka City Med J   46   37 - 53   2000

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  • Basic and clinical evaluation of a newly-developed enzymatic bilirubin assay. Reviewed

    Osaka City Med J   46   55 - 70   2000

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  • Clinical significance of simultaneous determination of serum soluble transferrin receptor, soluble Fas, soluble Fas ligand, hepatocyte growth factor and interleukin 18 levels in a patient with hemophagocytic syndrome. Reviewed

    Acta Haematol.   103 ( 3 )   165 - 167   2000

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  • Human IL-18 bioactivity in hematological malignancies with highly elevated serum IL-18 levels. Reviewed

    Acta Haematol.   103 ( 3 )   162 - 164   2000

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  • Automated bone marrow analysis using the CD4000 automated haematology analyzer. Reviewed

    J Autom Method Manag Chem   22 ( 3 )   89 - 92   2000

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  • 非Hodgkinリンパ湯に対する自家末梢血幹細胞移植併用大量化学療法 Reviewed

    山根孝久、日野雅之、太田健介、高 起良、中前博久、青山泰孝、他

    癌と化学療法   27   1547 - 1555   2000

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  • Hirudin as an anticoagulant for both haematology and chemistry tests. Reviewed

    J Autom Method Manag Chem   22 ( 4 )   109 - 112   2000

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  • Clinical significance of simultaneous measurement of reticulated platelets and large platelets in idiopathic thrombocytopenic purpura. Reviewed

    Haematologia   30 ( 3 )   183 - 192   2000

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  • Clinical usefulness of combined measurements of serum soluble transferrin receptor levels and serum interleukin-18 levels at determination of serum KL-6 levels in haematologic malignancies. Reviewed

    Acta Haematol   104 ( 2-3 )   141 - 143   2000

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  • Comparative study on complete remission rate and overall survival in three groups classified based on the serum interleukin-18 level in non-hodgkin"s lymphoma patients. Reviewed

    Acta Haematol   104 ( 4 )   220 - 222   2000

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  • Serum IL-18 levels in patients with various hematological disorders Reviewed

    Haematologia   30 ( 1 )   31 - 33   2000

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  • Cytokine-specific activation of elistinct mitogen-actirated protein kinase subtype cascades in human neutrophils stimulated by granulocyte colony-stimulating factor, granulocyte-macrophage colony-stimulating factor, and tumor necrosis factor-α Reviewed

    Blood   93 ( 1 )   341 - 349   1999.01

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  • Pathophysiological significance of simultaneous measurement of reticulated platelets, large platelets and serum thrombopoietin in non-neoplastic thrombocytopenic disorders. Reviewed

    Eur J Haematol   63 ( 5 )   295 - 301   1999

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  • An effective method for recovering CD34 positive progenitor cells from peripheral blood stem cell apheresis products cryopreserved with simplified method. Reviewed

    Osaka City Med J   45   139 - 148   1999

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  • HLA class II polymorphism in Thai patients with non-Hodgkin"s lymphoma. Reviewed

    Eur J Immunogenetics   26 ( 6 )   389 - 392   1999

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  • Relative distribution of myosin, actin, and α-actinin in adherent monocytes. Reviewed

    Eur J Histochem   43 ( 1 )   71 - 77   1999

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  • Serum soluble Fas ligand and soluble Fas levels in hematological disorders. Reviewed

    Medical Postgraduates   37   77 - 79   1999

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  • First basic performance evaluation of the XE-2100 haematology analyzer. Reviewed

    Medical Postgraduates   37   65 - 67   1999

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  • Automated enumeration of cellular composition in bone marrow aspirate with the CELL-DYN 4000 automated hematology analyzer. Reviewed

    Acat Hematol   101 ( 3 )   130 - 134   1999

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  • Nonspecific response of enzyme immunosaasy system to myeloperoxidase antigen released from blast cells in patients with nonlymphocytic leukemia. Reviewed

    Lab Hematol   24   120 - 123   1999

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  • Successful treatment of pustulosis palmaris et plantaris with granulocyte colony stimulating factor in a patient with hereditary neutropenia. Reviewed

    Hino M, Yamane T, Kuwaki T, Kono T, Kitagawa S, Tatsumi N

    Int J Hematol   68 ( 4 )   453 - 456   1998.12

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  • Study on the measurement of the percentage of viable cells in frozen peripheral blood stem cell harvesting samples by an automated hematology analyzer. Reviewed

    Aoyama Y, Yamane T, Ohta K, Hino M, Tatsumi N.

    Eur J Haematol   61 ( 5 )   356 - 357   1998.11

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  • Localization of myosin, actin, alpha-actinin, tropomyosin and vinculin in surface-activated, spreading human platelets. Reviewed

    Takubo T, Hino M, Suzuki K, Tatsumi N.

    Biotech Histochem   73 ( 6 )   310 - 315   1998.11

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  • Determination of hematopoietic stem cells in peripheral blood by an automated hematology analyzer (SE-9000). Reviewed

    Takekawa K, Yamane T, Hino M, Tatsumi N.

    Acta Haematol   100 ( 3 )   130 - 136   1998.10

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  • Expression of the Leptin recoptor in human leukemic blast cells. Reviewed

    British Journal of Haematology   102 ( 3 )   740 - 745   1998.08

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  • Problems with assays based on fibrin clot formation principle: analysis of multilaboratory data. Reviewed

    Hirai N, Tatsumi N, Hino M, Yamane T, Ohta K

    Osaka City Med J   44 ( 1 )   55 - 71   1998.06

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  • 一般病院での自家末梢血幹細胞移植の施行経験とその臨床的検討 Reviewed

    太田忠信、岸田卓也、長谷川太郎、平井 学、山根孝久、日野雅之、巽 典之

    臨床血液   39 ( 5 )   355 - 362   1998.05

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  • Relative distribution of myosin, actin and alpha-actinin in surface-activated, spreading platelets Reviewed

    Takubo T, Hino M, Suzuki K, Tatsumi N.

    Eur J Haematol   60 ( 5 )   307 - 309   1998.05

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  • Amplicor CMV PCRキットで得られるPCR増幅産物を電気泳動法で確認するための至適条件の検討 Reviewed

    橋本卯巳、日吉基文、田窪孝行、田川進一、巽 典之

    Jpn J Electroph   42   181 - 184   1998

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  • Method to evaluate an automated slide maker and stainer system tested on the CELL-DYN SMS. Reviewed

    Tatsumi N, Tsuda I, Takubo T, Hino M, Imai T, van Hove L.

    Lab Hematol   4   58 - 63   1998

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  • Peripheral blood stem cell transplantation for non-Hodgkin's lymphoma in complete remission. Reviewed

    Yamane T, Hino M, Ohta K, Nakao T, Nakamae H, Yamamura R, Takubo T, Tatsumi N

    Osaka City Med J   44 ( 2 )   219 - 223   1998

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  • The value of serum soluble transferrin receptor (sTfR) determination in hematological malignancies. Reviewed

    Takubo T, Yamane Y, Hino M, Hashimoto S, Koh KR, Sakamoto C, Kamitani T, Tatsumi N, Hikawa A

    Haematologia   29 ( 3 )   259 - 260   1998

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  • Localization of myosin, actin, and α-actinin in surface-activated, spresding human platelets. Reviewed

    Takubo T, Hino M, Tatusmi N

    J Anal Bio-Sci   73   155 - 157   1998

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  • Microscopical localization of actin-associated proteins alpha-actinin, tropomyosin and vinculin in motile human neutrophils. Reviewed

    Takubo T, Hino M, Suzuki K, Tatsumi N.

    Eur J Histochem   42 ( 3 )   237 - 239   1998

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  • Usefulness of determining reticulated and large platelets in idiopathic thrombocytopenic purpura. Reviewed

    Takubo T, Yamane T, Hino M, Tsuda I, Tatsumi N.

    Acta Haematol   99 ( 2 )   109 - 110   1998

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  • Thrombopoietin inhibits in vitro osteoclastogenesis from murine bone marrow cells. Reviewed

    Wakikawa T, Shioi A, Hino M, Inaba M, Nishizawa Y, Tatsumi N, Morii H, Otani S

    Endocrinology   138 ( 10 )   4160 - 4166   1997.10

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  • Molecular analysis of the t(8;21)(q22;q22) translocation in a case of acute myelomonocytic leukemia (AML-M4) Reviewed

    Nakao T, Hino M, Kumura T, Yamane T, Tatsumi N

    Eur J Haematol   59 ( 2 )   126 - 127   1997.08

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  • Inhibition by 1alpha,25-dihydroxyvitamin D3 of activin A-induced differentiation of murine erythroleukemic F5-5 cells. Reviewed

    Nagasaki T, Hino M, Inaba M, Nishizawa Y, Morii H, Otani S

    Arch Biochem Biophys   343 ( 2 )   181 - 187   1997.07

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  • In vitro expansion of mature neutrophils from isolated peripheral blood stem cells. Reviewed

    Hasuike T, Hino M, Yamane T, Tatsumi N

    Osaka City Med J   43 ( 1 )   61 - 68   1997.06

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  • Effects of TNP-470, a potent angiogenesis inhibitor, on growth of hematopoietic progenitors. Reviewed

    Hasuike T, Hino M, Yamane T, Nishizawa Y, Morii H, Tatsumi N.

    Eur J Haematol   58 ( 4 )   293 - 294   1997.04

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  • Change in FAS antigen expression during differentiation of CD34-positive cells isolated from peripheral blood stem cell harvest samples. Reviewed

    Yamane T, Hino M, Tatsumi N.

    Eur J Haematol   58 ( 4 )   289 - 290   1997.04

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  • Change in reticulated platelet count before and after leukocyte removal filtration for platelet concentrate transfusion. Reviewed

    Koh KR, Yamane T, Ohta K, Hino M, Tatsumi N.

    Laboratory Hematology   3   316 - 318   1997

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  • Identification of hematopoietic stem cells by the SE-9000 automated hematology analyzer in peripheral blood stem cell harvest samples. Reviewed

    Takekawa K, Yamane T, Suzuki K, Hino M, Tatsumi N.

    Acta Haematol   98 ( 1 )   54 - 55   1997

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  • Hepatocyte growth factor levels in bone marrow plasma of patients with leukaemia and its gene expression in leukaemic blast cells. Reviewed

    Hino M, Inaba M, Goto H, Nishizawa Y, Tatsumi N, Nishino T, Morii H

    Br J Cancer.   73 ( 1 )   119 - 123   1996.01

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  • Effect of 1,25-dihydroxyvitamin D3 on induction of scavenger receptor and differentiation of 12-O-tetradecanoylphorbol-13-acetate-treated THP-1 human monocyte like cells. Reviewed

    Suematsu Y, Nishizawa Y, Shioi A, Hino M, Tahara H, Inaba M, Morii H, Otani S

    J Cell Physiol   165 ( 3 )   547 - 555   1995.12

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  • Constitutive expression of the thrombopoietin gene in a human hepatoma cell line. Reviewed

    Hino M, Nishizawa Y, Tagawa S, Yamane T, Morii H, Tatsumi N

    Biochem Biophys Res Commun   217 ( 2 )   475 - 481   1995.12

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  • Down-modulation of c-kit mRNA and protein expression by erythroid differentiation factor/activin A. Reviewed

    Hino M, Nishizawa Y, Tatsumi N, Tojo A, Morii H

    FEBS Lett   374 ( 1 )   69 - 71   1995.10

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  • Establishmment and characterization of IRTA17 and IRTA21 two novel acute non-lymphocytic leukaemia cell lines with t(16;21) translocation. Reviewed

    Hiyoshi M ,Yamane T, Hirai M, Harroti H, Nakao Y, Yasui Y, Koh K-R, Hino M, Tatsumi N

    Br J Haematol   90 ( 2 )   417 - 424   1995.06

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  • c-kit-positive cells and CD34-positive cells in cryopreserved peripheral blood stem cell samples. Reviewed

    Yamane T, Hino M, Park K, Im T, Tatsumi N, ON Thalang

    Acta Haematol   94 ( 2 )   112 - 113   1995

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  • Parathyroid hormone-related peptide and models of vascular disease: its expression and action in vascular smooth muscle cells. Reviewed

    Nishizawa Y, Koyama H, Shioi A, Hosoi M, Jono S, Hino M, Morii H

    Miner Electrolyte Metab   21 ( 1*3 )   152 - 156   1995

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  • 造血器悪性腫瘍に対する自家末梢血幹細胞移植を併用したRanimustine,Cytarabine,EtoposideおよびCyclophosphamide併用療法の治療成績 Reviewed

    山根孝久、太田忠信、高 起良、橋本卯巳、竹川勝宏、平井信光、田中一巨、蓮池孝夫、平井 学、太田健介、大平秀公、中尾吉孝、安井良則、日吉基文、日野雅之、佐々木安津子、朴 勤植、任 太性、巽 典之

    癌と化学療法   21 ( 6 )   903 - 906   1994.05

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  • Impaired homologous upregulation of vitamin D receptor in rats with chronic renal failure. Reviewed

    Koyama H, Nishizawa Y, Inaba M, Hino M, Prahl JM, DeLuca HF, Morii H

    Am J Physiol   266 ( 5 Pt 2 )   F706 - F712   1994.05

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  • CD34陽性細胞数を造血回復の指標とした末梢血幹細胞移植の試み Reviewed

    山根孝久、日野雅之、麦谷安津子、朴 勤植、任 太性、橋本卯巳、太田忠信、高 起良、巽 典之

    BIOTHERAPY   8 ( 11 )   1453 - 1456   1994

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  • Regulation of release of hepatocyte growth factor from human promyelocytic leukemia cells, HL-60, by 1,25-dihydroxyvitamin D3, 12-O-tetradecanoylphorbol 13-acetate, and dibutyryl cyclic adenosine monophosphate. Reviewed

    Inaba M, Koyama H, Hino M, Okuno S, Terada M, Nishizawa Y, Nishino T, Morii H

    Blood   82 ( 1 )   53 - 59   1993.07

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  • Possible selective effects of interferon alpha-2b on a malignant clone in a case of polycythemia vera. Reviewed

    Hino M, Futami E, Okuno S, Miki T, Nishizawa Y, Morii H

    Ann Hematol   66 ( 3 )   161 - 162   1993.03

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  • A highly conserved tyrosine residue at codon 845 within the kinase domain is not required for the transforming activity of human epidermal growth factor receptor. Reviewed

    Gotoh N, Tojo A, Hino M, Yazaki Y, Shibuya M

    Biochem Biophys Res Commun   186 ( 2 )   768 - 774   1992.07

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  • Unregulated expression of the erythropoietin receptor gene caused by insertion of spleen focus-forming virus long terminal repeat in a murine erythroleukemia cell line. Reviewed

    Hino M, Tojo A, Misawa Y, Morii H, Takaku F, Shibuya M

    Mol Cell Biol   11 ( 11 )   5527 - 5533   1991.11

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  • Enhancing effect of ubenimex (bestatin) on proliferation and differentiation of hematopoietic progenitor cells, and the suppressive effect on proliferation of leukemic cell lines via peptidase regulation. Reviewed

    Shibuya K, Chiba S, Hino M, Kitamura T, Miyagawa K, Takaku F, Miyazano K.

    Biomed Pharmacother   45 ( 2-3 )   71 - 80   1991

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  • Erythropoietin treatment for anemia in end-stage renal disease with diabetes mellitus. Reviewed

    Nakatsuka K, Hino M, Miki T, Nishizawa Y, Tabata T, Inoue T, Morii H

    Diabetes Care   13 ( 11 )   1130 - 1131   1990.11

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  • Radioimmunoassay for erythropoietin using anti-recombinant erythropoietin antibody with high affinity. Reviewed

    Matsubara K, Yoshimura T, Kamachi S, Fukushima M, Hino M, Morii H

    Clin Chim Acta   185 ( 2 )   177 - 184   1989.11

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  • Characterization of cellular receptors for erythroid differentiation factor on murine erythroleukemia cells. Reviewed

    Hino M, Tojo A, Miyazono K, Miura Y, Chiba S, Eto Y, Shibai H, Takaku F

    J Biol Chem   264 ( 17 )   10309 - 10314   1989.06

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  • Treatment of myelodysplastic syndromes with recombinant human granulocyte colony-stimulating factor: a preliminary report. Reviewed

    Kobayashi Y, Okabe T, Ozawa K, Chiba S, Hino M, Miyazono K, Urabe A, Takaku F.

    Am J Med   86 ( 2 )   178 - 182   1989.02

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  • Effects of type beta transforming growth factors on haematopoietic progenitor cells. Reviewed

    Hino M, Tojo A, Miyazono K, Urabe A, Takaku F.

    Br J Haematol   70 ( 2 )   143 - 147   1988.10

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Books and Other Publications

  • 自家・同種骨髄・末梢血幹細胞の採取方法、ドナーの安全管理

    日野雅之、西本光孝、梅本由香里、中前博久( Role: Contributor)

    医薬ジャーナル社、みんなに役立つ造血幹細胞移植の基礎と臨床(改訂第3版)  2016.06 

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    Responsible for pages:275-283  

  • 造血幹細胞移植時の心筋障害

    中前博久, 中根孝彦, 日野雅之( Role: Sole author)

    医薬ジャーナル社、血液疾患治療に伴う合併症対策  2015.08 

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    Total pages:180   Responsible for pages:189   Book type:Scholarly book

  • 末梢血幹細胞採取

    日野雅之、中前博久、梅本由香里( Role: Contributor)

    医薬ジャーナル社、G-CSFの基礎と臨床  2015.07 

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    Total pages:175   Responsible for pages:186  

  • 自家・同種骨髄・末梢血幹細胞の採取方法、ドナーの安全管理

    日野雅之、中前博久、中根孝彦、梅本由香里( Role: Contributor)

    医薬ジャーナル社、みんなに役立つ造血幹細胞移植の基礎と臨床(改訂版)  2012.08 

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    Total pages:246   Responsible for pages:256  

  • 急激な片麻痺および意識障害で発症しMASS EFFECTを呈したシクロスポリン脳症

    日野雅之、康 秀男( Role: Contributor)

    医薬ジャーナル社、標本に学ぶ血液疾患症例  2012.01 

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    Total pages:322   Responsible for pages:327  

  • 内臓播種性水痘帯状疱疹ウイルス感染症[診療のコツ]

    日野 雅之( Role: Sole author)

    医薬ジャーナル社、症例とエビデンスに学ぶ造血細胞移植と感染症  2011.08 

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    Total pages:36   Responsible for pages:39  

  • 抗菌薬不応性発熱が持続する好中球減少症に対する経験的抗真菌治療および侵襲性アスペルギルス症の先制治療

    寺田芳樹、日野雅之( Role: Contributor)

    医薬ジャーナル社、IDSAガイドライン  2010.10 

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    Total pages:221   Responsible for pages:229  

  • 自家・同種骨髄・末梢血幹細胞の採取方法、ドナーの安全管理

    日野雅之、山根孝久、中前博久( Role: Contributor)

    医薬ジャーナル社、みんなに役立つ造血幹細胞移植の基礎と臨床  2008.09 

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    Total pages:200   Responsible for pages:205  

  • 造血細胞移植時の心筋障害とその対策

    中前博久、中根孝彦、日野雅之( Role: Contributor)

    医薬ジャーナル社、血液疾患治療の支持療法-最近の進歩  2006.12 

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    Total pages:134   Responsible for pages:143  

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MISC

  • 左結膜に限局性の微小形質転換びまん性大細胞型B細胞リンパ腫(Tiny transformed diffuse large B cell lymphoma localized to the left conjunctiva)

    Harada Naonori, Tagami Mizuki, Koh Hideo, Ohsawa Masahiko, Hino Masayuki, Nakamae Hirohisa

    International Journal of Hematology   114 ( 4 )   413 - 414   2021.10( ISSN:0925-5710

  • 赤白血病におけるマスター転写因子のドライバー変異

    康 秀男, 日野 雅之

    血液内科   82 ( 5 )   704 - 710   2021.05( ISSN:2185-582X

  • アカデミアにおけるイノベーション創出に向けた取り組み レギュレーションを制する者はイノベーションを制する Reviewed

    日下部 哲也, 立石 千晴, 藤井 比佐子, 西川 武司, 南 千華子, 西宇 美恵子, 日野 雅之

    (一社)レギュラトリーサイエンス学会 レギュラトリーサイエンス学会誌   10 ( 3 )   139 - 152   2020.09( ISSN:2185-7113

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    医薬品医療機器等法で取り扱うレギュレーションは、医薬品・医療機器等の薬事関連製品の開発、承認審査、製造および市販後の各段階を厳格に制御している。アカデミアにおいても、医療イノベーションを達成するためには、医薬品等の基礎研究・臨床研究を実施するにあたって、薬事レギュレーションの熟知と遵守が求められる。近年、AROはアカデミアにおける薬事関連製品などの新規開発を促進するため、基礎研究から臨床研究・治験、実用化までの工程を一貫して支援する組織として、アカデミアの内部に設置されるようになってきた。特に、オープンイノベーションにおいては、アカデミアの役割が大きく期待されており、大阪市立大学では、「レギュレーションを制する者はイノベーションを制する」をキャッチフレーズに掲げ、各種ARO活動を精力的に進めてきた。本稿では、アカデミアにおけるイノベーション創出に向けた取り組みとして、大阪市立大学医学部附属病院にAROとして設置された臨床研究・イノベーション推進センターが担うイノベーション創出への取り組みの状況を紹介するとともに、イノベーションと相互浸透の関係にあるレギュレーションへのアカデミアの関わりについて考察する。(著者抄録)

  • 【造血器腫瘍学(第2版)-基礎と臨床の最新研究動向-】造血器腫瘍の診断と治療 診断・検査法 遺伝子検査 Reviewed

    西本 光孝, 日野 雅之

    (株)日本臨床社 日本臨床   78 ( 増刊3 造血器腫瘍学 )   193 - 197   2020.08( ISSN:0047-1852

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  • 尿沈渣分析装置AUTION EYE AI-4510の基礎性能評価 Reviewed

    長岡 智香, 川口 咲乃, 谷上 朋子, 久保田 浩, 阿部 篤, 中前 美佳, 日野 雅之

    ラボ・サービス 医療と検査機器・試薬   43 ( 4 )   410 - 416   2020.08( ISSN:1347-0434

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  • 急性骨髄性白血病のエピゲノムを標的とした治療 Reviewed

    康 秀男, 星居 孝之, 日野 雅之

    (有)科学評論社 血液内科   81 ( 1 )   93 - 100   2020.07( ISSN:2185-582X

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  • 悪性腹膜中皮腫の確定診断のための、超音波内視鏡ガイド下細径針生検(Endoscopic ultrasound-guided fine-needle biopsy for definitive diagnosis of malignant peritoneal mesothelioma) Reviewed

    Higashino Masayuki, Sugiura Ryo, Sakamoto Naoya

    John Wiley & Sons Australia, Ltd Digestive Endoscopy   32 ( 3 )   e40 - e42   2020.03( ISSN:0915-5635

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  • 【溶血性貧血up to date】リンパ系腫瘍と溶血性貧血 Reviewed

    日野 雅之

    (有)科学評論社 血液内科   78 ( 2 )   228 - 233   2019.02( ISSN:2185-582X

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  • 【貧血学-最新の診断・治療動向-】疾患が原因による貧血の予防・管理 血液腫瘍による貧血の予防・管理 Reviewed

    日野 雅之

    (株)日本臨床社 日本臨床   75 ( 増刊1 貧血学 )   559 - 563   2017.01( ISSN:0047-1852

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  • KLF1変異による多彩な貧血症状 Reviewed

    中根 孝彦, 日野 雅之

    (有)科学評論社 血液内科   73 ( 6 )   828 - 833   2016.12( ISSN:2185-582X

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  • Prophylactic Use of a Combination of an Anticoagulant and Ursodeoxycholic Acid for Sinusoidal Obstruction Syndrome after Allogeneic Myeloablative Hematopoietic Stem Cell Transplantation

    Hiroshi Okamura, Mitsutaka Nishimoto, Takahiko Nakane, Hideo Koh, Yasuhiro Nakashima, Yasunobu Takeoka, Mika Nakamae, Asao Hirose, Masayuki Hino, Hirohisa Nakamae

    BLOOD   128 ( 22 )   2016.12( ISSN:0006-4971 ( eISSN:1528-0020

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  • Short-Term Fasting Induces Cell Cycle Arrest of Immature Hematopoietic Cells and Increases the Number of Naive T Cells in the Bone Marrow of Mice

    Teruhito Takakuwa, Yasuhiro Nakashima, Hideo Koh, Takahiko Nakane, Hirohisa Nakamae, Masayuki Hino

    BLOOD   128 ( 22 )   2016.12( ISSN:0006-4971 ( eISSN:1528-0020

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  • 経口鉄剤内服後24時間の鉄吸収低下 Reviewed

    中前 美佳, 日野 雅之

    (有)科学評論社 血液内科   73 ( 4 )   528 - 533   2016.10( ISSN:2185-582X

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  • KLF-1変異による多彩な貧血症状 Invited

    中根孝彦、日野雅之

    血液内科   73 ( 6 )   828 - 833   2016.06

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  • 【汎血球減少症】巨赤芽球性貧血における汎血球減少 Reviewed

    日野 雅之, 今井 重良

    (有)科学評論社 血液内科   72 ( 6 )   771 - 776   2016.06( ISSN:2185-582X

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  • KLF-1変異による多彩な貧血症状 Reviewed

    中根孝彦, 日野雅之

    血液内科   73 ( 6 )   828 - 833   2016.06

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  • 【汎血球減少症】巨赤芽球性貧血における汎血球減少 Reviewed

    日野 雅之, 今井 重良

    (有)科学評論社 血液内科   72 ( 6 )   771 - 776   2016.06( ISSN:2185-582X

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  • Qualitative Analysis of Patient-Reported Free Comments on Quality of Life in Patients Who Completed Treatment for Acute Leukemia

    Ayako Mori, Mayumi Tsukagoshi, Saiko Kurosawa, Takehiko Mori, Heiwa Kanamori, Yasushi Onishi, Nobuhiko Emi, Shin Fujisawa, Akio Kohno, Chiaki Nakaseko, Bungo Saito, Tadakazu Kondo, Masayuki Hino, Yuichiro Nawa, Shunichi Kato, Akiko Hashimoto, Yoshihiro Inamoto, Takahiro Fukuda

    BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION   22 ( 3 )   S454 - S455   2016.03( ISSN:1083-8791 ( eISSN:1523-6536

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  • 【免疫症候群(第2版)-その他の免疫疾患を含めて-】続発性免疫不全症候群 各種疾患・病態にみられる免疫異常 造血器疾患にみられる免疫異常 急性骨髄性白血病 Reviewed

    日野 雅之

    (株)日本臨床社 日本臨床   別冊 ( 免疫症候群II )   738 - 742   2016.01( ISSN:0047-1852

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  • 【免疫症候群(第2版)-その他の免疫疾患を含めて-】続発性免疫不全症候群 各種疾患・病態にみられる免疫異常 造血器疾患にみられる免疫異常 急性骨髄性白血病 Reviewed

    日野 雅之

    (株)日本臨床社 日本臨床   別冊 ( 免疫症候群II )   738 - 742   2016.01( ISSN:0047-1852

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  • Waldenstroemマクログロブリン血症細胞の起源と進展

    康 秀男、日野雅之

    血液内科   71 ( 6 )   781 - 786   2016

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  • Waldenstroemマクログロブリン血症細胞の起源と進展 Reviewed

    康 秀男, 日野雅之

    血液内科   71 ( 6 )   781 - 786   2016

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  • Waldenstroemマクログロブリン血症細胞の起源と進展 Reviewed

    康 秀男, 日野 雅之

    (有)科学評論社 血液内科   71 ( 6 )   781 - 786   2015.12( ISSN:2185-582X

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  • Pre-Transplant Autonomic Nervous System Malfunction Is a Powerful Predictor for Survival after Allogeneic Hematopoietic Cell Transplantation

    Takahiko Nakane, Mika Nakamae, Hideo Koh, Mitsutaka Nishimoto, Yoshiki Hayashi, Asao Hirose, Yasuhiro Nakashima, Masayuki Hino, Hirohisa Nakamae

    BLOOD   126 ( 23 )   2015.12( ISSN:0006-4971 ( eISSN:1528-0020

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  • イラストレイテッド・サージェリー 手術編 感染性脊椎炎に対する二期的手術法 Reviewed

    清水 克時, 日野 雅之, 藤田 勝, 松田 芳郎, 安良 興, 宮本 敬

    (株)三輪書店 脊椎脊髄ジャーナル   28 ( 9 )   767 - 773   2015.09( ISSN:0914-4412

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  • 転写開始因子のTIF-1Aのsplicing variantであるTIF-90は白血病細胞においてリボソームRNAの生成を促進する Reviewed

    中嶋 康博, 日野 雅之

    (有)科学評論社 血液内科   70 ( 5 )   617 - 621   2015.05( ISSN:2185-582X

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  • 転写開始因子のTIF-1Aのsplicing variantであるTIF-90は白血病細胞においてリボソームRNAの生成を促進する Reviewed

    中嶋 康博, 日野 雅之

    (有)科学評論社 血液内科   70 ( 5 )   617 - 621   2015.05( ISSN:2185-582X

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  • エストロゲンβ型の受容体刺激はリンパ腫の血管新生ならびに播種を抑制する Reviewed

    中嶋 康博, 日野 雅之

    (有)科学評論社 血液内科   69 ( 6 )   769 - 773   2014.12( ISSN:2185-582X

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  • エストロゲンβ型の受容体刺激はリンパ腫の血管新生ならびに播種を抑制する Reviewed

    中嶋 康博, 日野 雅之

    (有)科学評論社 血液内科   69 ( 6 )   769 - 773   2014.12( ISSN:2185-582X

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  • APLの臨床と最新治療 Reviewed

    日野 雅之

    (一社)日本検査血液学会 日本検査血液学会雑誌   15 ( 3 )   357 - 363   2014.11( ISSN:1347-2836

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    急性前骨髄球性白血病(APL)は、豊富なアズール顆粒とFaggot細胞の存在、特徴的な染色体異常t(15;17)(q22;q12)、遺伝子異常PML-RARAで診断は容易であるが、微細な顆粒を有する非典型的なタイプもある。APL細胞は、全トランス型レチノイン酸(ATRA)や亜ヒ酸により分化誘導され、化学療法との併用により最も治癒率の高い白血病となった。地固め治療後、分子生物学的寛解が得られることが重要で、再発した場合は、亜ヒ酸などにより分子生物学的再寛解が得られれば自家造血幹細胞移植が有効であり、非寛解の場合は同種造血幹細胞移植が検討される。APLは発病初期から線溶亢進型播種性血管内凝固症候群を高頻度に合併し、脳出血などの致死的臓器障害による早期死亡が問題となるため、緊急入院の適応である。APLは早期診断、早期治療がきわめて重要であり、臨床検査技師の果たす役割は大きい。(著者抄録)

  • 急性骨髄性白血病におけるarginaseを介した免疫抑制性の微小環境 Reviewed

    中嶋 康博, 日野 雅之

    (有)科学評論社 血液内科   69 ( 1 )   140 - 144   2014.07( ISSN:2185-582X

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  • 急性骨髄性白血病におけるarginaseを介した免疫抑制性の微小環境 Reviewed

    中嶋 康博, 日野 雅之

    (有)科学評論社 血液内科   69 ( 1 )   140 - 144   2014.07( ISSN:2185-582X

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  • HLA一致血縁または7‐8/8HLA一致非血縁ドナーからの同種造血細胞移植におけるMMFおよびカルシニューリン阻害剤を用いたGVHD予防の有用性:多施設共同第2相臨床試験

    中根孝彦, 中前博久, 黒澤彩子, 岡村篤夫, 日高道弘, 山下卓也, 河野彰夫, 齋藤健, 青山泰孝, 畑中一生, 片山義雄, 薬師神公和, 松井利充, 高見昭良, 山口拓洋, 日野雅之, 福田隆浩

    日本造血細胞移植学会総会プログラム・抄録集   36th   238   2014.02

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  • APLの臨床と最新治療

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    日本検査血液学会雑誌   15   357 - 363   2014

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  • APLの臨床と最新治療 Reviewed

    日野 雅之

    日本検査血液学会雑誌   15   357 - 363   2014

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  • MDSにおいてmiR-21はTGF-βシグナルを介して造血を抑制する Reviewed

    中嶋 康博, 日野 雅之

    (有)科学評論社 血液内科   67 ( 6 )   767 - 772   2013.12( ISSN:2185-582X

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  • MDSにおいてmiR-21はTGF-βシグナルを介して造血を抑制する Reviewed

    中嶋 康博, 日野 雅之

    (有)科学評論社 血液内科   67 ( 6 )   767 - 772   2013.12( ISSN:2185-582X

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  • 移植後のシクロフォスファミド大量療法を用いたHLA半合致同種造血細胞移植法(ハプロ移植) Reviewed

    中前 博久, 日野 雅之

    「血液診療」編集委員会 血液診療   10 ( Suppl. )   37 - 38   2013.12

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  • 移植後のシクロフォスファミド大量療法を用いたHLA半合致同種造血細胞移植法(ハプロ移植) Reviewed

    中前 博久, 日野 雅之

    「血液診療」編集委員会 血液診療   10 ( Suppl. )   37 - 38   2013.12

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  • Diagnostic Value Of Serum Level Of Soluble CD14-Subtype In Febrile Neutropenia In Patients With Hematologic Disorders

    Hideo Koh, Hirohisa Nakamae, Mizuki Aimoto, Takako Katayama, Asao Hirose, Mika Nakamae, Masayuki Hino

    BLOOD   122 ( 21 )   2013.11( ISSN:0006-4971 ( eISSN:1528-0020

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  • HLA Haplo-Identical Peripheral Blood Stem Cell Transplantation Using High-Dose Cyclophosphamide Post-Transplantation For Poor Prognosis Or Refractory Acute Leukemia and Myelodysplastic Syndrome: A Prospective Pilot Study At a Single Center

    Hirohisa Nakamae, Hideo Koh, Mitsutaka Nishimoto, Yasuhiro Nakashima, Satoru Nanno, Takuro Yoshimura, Shiro Koh, Hiroshi Okamura, Jyoji Nagasaki, Takahiko Nakane, Mika Nakamae, Asao Hirose, Masayuki Hino

    BLOOD   122 ( 21 )   2013.11( ISSN:0006-4971 ( eISSN:1528-0020

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  • 整形外科分野における神経障害の研究 病態の解明と治療法の開発 Reviewed

    尾形 直則, 森野 忠夫, 堀内 秀樹, 山岡 豪大朗, 森実 圭, 日野 雅之, 濱本 雄一郎, 三浦 裕正

    愛媛医学会 愛媛医学   32 ( 3 )   171 - 177   2013.09( ISSN:0286-3677

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  • EVALUATION OF EFFICACY AND SAFETY OF BENDAMUSTINE TREATMENT IN OSAKA LYMPHOMA STUDY GROUP(OLSG) OF JAPAN

    T. Kohara, H. Shibayama, N. Uoshima, Y. Terada, E. Nakatani, H. Yoshida, J. Ishikawa, H. Masaie, A. Mugitani, T. Kumura, S. Okamoto, Y. Kamitsuji, H. Sugahara, M. Nakagawa, M. Kawakami, J. Ishiko, H. Take, S. Kosugi, S. Nakata, Y. Nagate, T. Kida, Y. Moriyama, Y. Kataoka, N. Tominaga, T. Morita, S. Inoue, M. Yamada, F. Urase, A. Toda, K. Hayashi, N. Nakamichi, Y. Tokumine, A. Inoue, T. Tamaki, M. Tsukaguchi, M. Shibano, H. Hattori, M. Kuwayama, N. Anzai, M. Matsuda, S. Ueda, H. Matsunaga, H. Mitsui, K. Hashimoto, N. Wada, E. Morii, Y. Kanakura, M. Hino

    HAEMATOLOGICA   98   643 - 643   2013.06( ISSN:0390-6078

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  • Prognostic Value for Survival of Serum Ferritin Levels Over Time After Allogeneic Hematopoietic Cell Transplantation

    Mika Nakamae, Hirohisa Nakamae, Hideo Koh, Takahiko Nakane, Mitsutaka Nishimoto, Asao Hirose, Masayuki Hino

    BLOOD   120 ( 21 )   2012.11( ISSN:0006-4971

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  • Short Cycle of Immunochemotherapy Followed by Radiation Therapy Compared with Prolonged Cycles of Immunochemotherapy for Localized DLBCL: The Osaka Lymphoma Study Group (OLSG) Retrospective Analysis

    Yoshiki Terada, Hironori Take, Hirohiko Shibayama, Koji Hashimoto, Maki Kuwayama, Norie Fujii, Yasuhiko Azenishi, Yasuhiro Maeda, Tamotu Yamagami, Nobuhiko Uoshima, Machiko Tsukaguchi, Osamu Semba, Hideki Mitui, Shuji Ueda, Toshihiro Soma, Masashi Nakagawa, Mituhiro Matuda, Fumiaki Urase, Teruo Kiyoi, Hitoshi Yoshida, Hiroyuki Sugahara, Kenichi Yamashita, Nobuhiko Tominaga, Takeshi Kubota, Nobuyoshi Arima, Shinichirou Mori, Toshiharu Tamaki, Takahiro Okamoto, Naoyuki Anzai, Hiroshi Akasaka, Rie Tabata, Junichiro Ikeda, Naoki Wada, Katsuyuki Aozasa, Masayuki Hino

    BLOOD   120 ( 21 )   2012.11( ISSN:0006-4971

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    DOI: 10.1182/blood.V120.21.1628.1628

  • 【ドナーアフェレシスの現状と展開】非血縁者間末梢血幹細胞採取 Reviewed

    日野 雅之

    (一社)日本アフェレシス学会 日本アフェレシス学会雑誌   31 ( 3 )   209 - 215   2012.10( ISSN:1340-5888

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  • 【ドナーアフェレシスの現状と展開】非血縁者間末梢血幹細胞採取 Reviewed

    日野 雅之

    (一社)日本アフェレシス学会 日本アフェレシス学会雑誌   31 ( 3 )   209 - 215   2012.10( ISSN:1340-5888

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  • 慢性炎症に伴う貧血のhepcidin抑制による治療 Reviewed

    寺田 芳樹, 日野 雅之

    (有)科学評論社 血液内科   65 ( 4 )   591 - 598   2012.10( ISSN:2185-582X

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  • 慢性炎症に伴う貧血のhepcidin抑制による治療 Reviewed

    寺田 芳樹, 日野 雅之

    (有)科学評論社 血液内科   65 ( 4 )   591 - 598   2012.10( ISSN:2185-582X

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  • 大阪市大発信、ドナーサンクスカード運動 Reviewed

    日野 雅之, 梅本 由香里, 美濃 全代, 古川 まゆみ, 稲崎 水奈子, 田中 和子, 今井 重良, 池本 彩, 奥井 靖子, 今久保 千佳, 蓮輪 亮介

    「血液診療」編集委員会 血液診療   9 ( 1 )   22 - 23   2012.07

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  • 診療科内での臨床研究支援部門についての現況と課題について Reviewed

    中前 美佳, 片山 貴子, 梅本 由香里, 井上 有希子, 樋口 智子, 津田 泉, 廣瀬 朝生, 日野 雅之

    「血液診療」編集委員会 血液診療   9 ( 1 )   15 - 19   2012.07

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  • 大阪市大発信、ドナーサンクスカード運動 Reviewed

    日野 雅之, 梅本 由香里, 美濃 全代, 古川 まゆみ, 稲崎 水奈子, 田中 和子, 今井 重良, 池本 彩, 奥井 靖子, 今久保 千佳, 蓮輪 亮介

    「血液診療」編集委員会 血液診療   9 ( 1 )   22 - 23   2012.07

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  • 診療科内での臨床研究支援部門についての現況と課題について Reviewed

    中前 美佳, 片山 貴子, 梅本 由香里, 井上 有希子, 樋口 智子, 津田 泉, 廣瀬 朝生, 日野 雅之

    「血液診療」編集委員会 血液診療   9 ( 1 )   15 - 19   2012.07

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  • 【造血器腫瘍学-基礎と臨床の最新研究動向-】造血器腫瘍の診断と治療 診断・検査法 遺伝子検査 Reviewed

    日野 雅之

    (株)日本臨床社 日本臨床   70 ( 増刊2 造血器腫瘍学 )   188 - 192   2012.04( ISSN:0047-1852

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  • 【造血器腫瘍学-基礎と臨床の最新研究動向-】造血器腫瘍の診断と治療 診断・検査法 遺伝子検査 Reviewed

    日野 雅之

    (株)日本臨床社 日本臨床   70 ( 増刊2 造血器腫瘍学 )   188 - 192   2012.04( ISSN:0047-1852

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