Updated on 2024/02/13

写真a

 
NAGASAKI Takeshi
 
Organization
Graduate School of Engineering Division of Science and Engineering for Materials, Chemistry and Biology Professor
School of Engineering Department of Chemistry and Bioengineering
Title
Professor
Affiliation
Institute of Engineering
Affiliation campus
Sugimoto Campus

Position

  • Graduate School of Engineering Division of Science and Engineering for Materials, Chemistry and Biology 

    Professor  2022.04 - Now

  • School of Engineering Department of Chemistry and Bioengineering 

    Professor  2022.04 - Now

Degree

  • Doctor of Engineering ( Kyushu University )

Research Areas

  • Life Science / Biomaterials  / Medical Bioengineering

  • Life Science / Biomedical engineering  / Medical Bioengineering

  • Manufacturing Technology (Mechanical Engineering, Electrical and Electronic Engineering, Chemical Engineering) / Biofunction and bioprocess engineering  / Biofunctional Engineering

Research Interests

  • Drug Delivery System

  • Anti-cancer agent

  • Cell Scaffold

  • Tissue Adhesive

  • Neutron Capture Therapy

Research subject summary

  • バイオ産業を支える基盤技術として細胞工学関連技術の重要性は今後益々増大すると期待される。その中でも細胞培養や遺伝子導入は多方面へ応用する際の基幹技術である。我々は、再生医療や遺伝子治療等の近未来に医療革命を引き起こす可能性がある先進医療を見据え、安全性と効率の高い遺伝子導入剤や培養基剤の開発を目指し研究を行っている。

Research Career

  • Boron Delivery System for Boron Neutron Capture Therapy

    Joint Research in Japan

    2010.04 - Now 

  • Hydrogel as Hemostat

    Hemostat, Hydro Gel  Joint Research in Japan

    2006.04 - Now 

  • Controlled Drug Delivery by Using Functional Protein

    drug delivery, intracellular trafficking, functional protein  Joint Research in Organization

    2000.04 - Now 

  • Development of Cell Culutre Devices

    cell culture, polycation, cell adhesion  Joint Research in Japan

    2003.04 - Now 

  • Biopolymer-based gene carrier

    gene carrier, biopolymer, polycation  Joint Research in Japan

    1999.04 - Now 

  • Protein Engineering Using Non-natural Amino Acid

    Non-natural amino acid, Protein engineering, Molecular Recognition  International Joint Research

    1900.04 - Now 

Professional Memberships

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Committee Memberships (off-campus)

  • Executive Board Member   Japanese Society of Neutron Capture Therapy  

    2021.07 - Now 

  • 行事委員   高分子学会  

    2015.06 - 2018.05 

  • 関西支部常任理事   高分子学会  

    2013.07 - 2020.06 

  • 評議員   日本バイオマテリアル学会  

    2012.04 - Now 

  • Board   Association of Research for Host-Guest and Supramolecular Chemistry  

    2008 - Now 

  • 評議員   日本DDS学会  

    2007 - Now 

  • フロンティア生命化学研究会理事   日本化学会  

    2004 - Now 

  • Board   The Japanese Society of Gene Design and Delivery  

    2000 - Now 

  • 協議会委員   大阪市立都島工業高等学校  

    2016.04 - Now 

  • 支部編集委員   高分子学会  

    2014.06 - 2016.05 

  • -   審議会・政策研究会等の委員会  

    2014.04 - 2015.03 

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    原子炉実験所共同利用課題審査委員

  • 代議員   高分子学会  

    2014.03 - 2018.03 

  • 近畿支部幹事   日本化学会  

    2014.03 - 2017.03 

  • 第23回ポリマー材料フォーラム 運営委員   高分子学会  

    2013.10 - 2014.11 

  • -   学会誌等の編集・審査委員会  

    2011.05 

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    Reviwer of J. Control. Release

  • -   審議会・政策研究会等の委員会  

    2011.04 - 2012.03 

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    大阪市島屋ビジネス・インキュベータ「インキュベーションオフィス入居審査会」審査委員長

  • -   文部科学省・日本学術振興会等による事業の審査委員会  

    2004.04 - 2005.03 

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    日本学術振興会・特別研究員等審査会専門委員

  • 近畿支部幹事   日本化学会  

    2003 - 2005 

  • 関西支部幹事   有機合成化学協会  

    1999 - 2001 

  • 編集協力委員   有機合成化学協会  

    1995 - 1997 

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Awards

  • Bull. Chem. Soc. Jpn. Award

    2007  

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    Country:Japan

  • HGCS Japan Award of Excellence 2006

    2006  

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    Country:Japan

  • Bull. Chem. Soc. Jpn. Award

    2004  

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    Country:Japan

  • 日本化学会生体機能関連化学部会部会講演賞

    2002  

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    Country:Japan

  • 日本化学会年会講演奨励賞

    1996  

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    Country:Japan

  • 荒川化学工業研究企画賞

    1995  

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    Country:Japan

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Job Career (off-campus)

  • 奈良高等専門学校非常勤講師   -

    2000 - 2005

  • Faculty of Engineering, Kyushu University   Research Associate

    1991 - 1994

Education

  • Kyushu University   Department of Organic Synthesis   Doctor's Course   Accomplished credits for doctoral program

    1988.04 - 1991.03

  • Tokyo University of Agriculture and Technology   Department of Applied Chemistry for Resources   Master's Course   Graduated/Completed

    1986.04 - 1988.03

  • Tokyo University of Agriculture and Technology   Department of Applied Chemistry for Resources     Graduated/Completed

    1982.04 - 1986.03

Papers

  • Widely distributable and retainable in-situ gelling material for treating myocardial infarction Reviewed

    Hue Thi Le ,Atsushi Mahara ,Kyoko Fukazawa ,Takeshi Nagasaki ,Tetsuji Yamaoka

    Acta Biomaterialia   2024

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    Publishing type:Research paper (scientific journal)   International / domestic magazine:International journal  

    DOI: 10.1016/j.actbio.2024.01.013

  • HER-2-targeted Boron Neutron Capture Therapy with Carborane-integrated Immunoliposomes Prepared via an Exchanging Reaction Reviewed

    Riku Kawasaki; Ayano Oshige; Keita Yamana; Hidetoshi Hirano; Kotaro Nishimura; Yamato Miura; Ryuji Yorioka; Yu Sanada; Kaori Bando; Anri Tabata; Kazuma Yasuhara; Yusuke Miyazaki; Wataru Shinoda; Tomoki Nishimura; Hideki Azuma; Takushi Takata; Yoshinori Sakurai; Hiroki Tanaka; Minoru Suzuki; Takeshi Nagasaki; Atsushi Ikeda

    Chemistry - A European Journal -   2023.10

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    Publishing type:Research paper (scientific journal)   International / domestic magazine:International journal  

    DOI: 10.1002/chem.202302486

  • HER-2-targeted boron neutron capture therapy using an antibody-conjugated boron nitride nanotube/β-1,3-glucan complex Reviewed

    Keita Yamana, Riku Kawasaki, Kousuke Kondo, Hidetoshi Hirano, Shogo Kawamura, Yu Sanada, Kaori Bando, Anri Tabata, Hideki Azuma, Takushi Takata, Yoshinori Sakurai, Hiroki Tanaka, Tomoki Kodama, Seiji Kawamoto, Takeshi Nagasaki, and Atsushi Ikeda

    Nanoscale Advances   5   3857 - 3861   2023.05

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1039/D3NA00028A

  • Phospholipid-Coated Boronic Oxide Nanoparticles as a Boron Agent for Boron Neutron Capture Therapy Reviewed

    Riku Kawasaki, Hidetoshi Hirano, Keita Yamana, Ayano Oshige, Kotaro Nishimura, Nanami Kono, Yu Sanada, Kaori Bando, Anri Tabata, Naoki Yasukawa, Hideki Azuma, Takushi Takata, Yoshinori Sakurai, Hiroki Tanaka, Minoru Suzuki, Naoki Tarutani, Kiyofumi Katagiri, Takeshi Nagasaki, Atsushi Ikeda

    ChemBioChem   2023.04

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    Publishing type:Research paper (scientific journal)   International / domestic magazine:International journal  

    DOI: 10.1002/cbic.202300186

  • Prevention of anastomotic stenosis for decellularized vascular grafts using rapamycin-loaded boronic acid-based hydrogels mimicking the perivascular tissue function Reviewed

    Hue Thi Le, Atsushi Mahara, Takeshi Nagasaki, and Tetsuji Yamaoka

    Biomaterials Adv.   147   213324   2023.02

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    Publishing type:Research paper (scientific journal)   International / domestic magazine:International journal  

    DOI: 10.1016/j.bioadv.2023.213324

  • Carborane bearing pullulan nanogel-boron oxide nanoparticle hybrid for boron neutron capture therapy Reviewed

    Riku Kawasaki, Hidetoshi Hirano, Keita Yamana, Hinata Isozaki, Shogo Kawamura, Yu Sanada, Kaori Bando, Anri Tabata, Kouhei Yoshikawa, Hideki Azuma, Takushi Takata, Hiroki Tanaka, Yoshinori Sakurai, Minoru Suzuki, Naoki Tarutani, Kiyofumi Katagiri, Shin-ichi Sawada, Yoshihiro Sasaki, Kazunari Akiyoshi, Takeshi Nagasaki, and Atsushi Ikeda

    Nanomed.: Nanotechnol. Biol. Med.   49   102659   2023.02

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    Publishing type:Research paper (scientific journal)   International / domestic magazine:International journal  

    DOI: 10.1016/j.nano.2023.102659

  • HER-2-targeted boron neutron capture therapy using an antibody-conjugated boron nitride nanotube/β-1,3-glucan complex Reviewed

    Keita Yamana, Riku Kawasaki, Kousuke Kondo, Hidetoshi Hirano, Shogo Kawamura, Yu Sanada, Kaori Bando, Anri Tabata, Hideki Azuma, Takushi Takata, Yoshinori Sakurai, Hiroki Tanaka, Tomoki Kodama, Seiji Kawamoto, Takeshi Nagasaki, and Atsushi Ikeda

    Nanoscale Advances   2023.01

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    Publishing type:Research paper (scientific journal)   International / domestic magazine:International journal  

    DOI: 10.1039/D3NA00028A

  • Caninization of Anti BSH Antibody Prepared from Rabbit Lymphocytes Reviewed

    N. Ueda, N. Yasukawa, R. Kawasaki, Y. Sakurai, H. Tanaka, Y. Sanada, N. Kondo, M. Suzuki, and T. Na-gasaki

    KURNS Progress Report 2022   2023

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    Authorship:Last author, Corresponding author   Publishing type:Research paper (bulletin of university, research institution)  

  • Combination Effect of Shikonin on BPA-BNCT toward SCCVII Cells-Bearing C3H Mice Reviewed

    K. Bando, A. Tabata, N. Yasukawa, R. Kawasaki, Y. Sakurai, Y. Sanada, M. Suzuki, N. Kondo, and T. Nagasaki

    KURNS Progress Report 2022   2023

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    Authorship:Last author, Corresponding author   Publishing type:Research paper (bulletin of university, research institution)  

  • A new "Mitsunobu homocoupling" reaction using aldol adducts of kojic acid Reviewed

    Azuma Hideki, Morishima Yasuhito, Nakaguro Keijin, Kato Reiko, Nagasaki Takeshi

    TETRAHEDRON   94   2021.08( ISSN:0040-4020

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.tet.2021.132314

  • Tumor-targeting hyaluronic acid/fluorescent carborane complex for boron neutron capture therapy Reviewed

    Yamana Keita, Kawasaki Riku, Sanada Yu, Tabata Anri, Bando Kaori, Yoshikawa Kouhei, Azuma Hideki, Sakurai Yoshinori, Masunaga Shin-ichiro, Suzuki Minoru, Sugikawa Kouta, Nagasaki Takeshi, Ikeda Atsushi

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   559   210 - 216   2021.06( ISSN:0006-291X

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.bbrc.2021.04.037

    PubMed

  • Mechanism toward Turn-on of Polysaccharide-Porphyrin Complexes for Fluorescence Probes and Photosensitizers in Photodynamic Therapy in Living Cells Reviewed

    Hino Shodai, Funada Rikushi, Sugikawa Kouta, Kawasaki Riku, Koumoto Kazuya, Suzuki Toshio, Nagasaki Takeshi, Ikeda Atsushi

    CHEMMEDCHEM   16 ( 5 )   793 - 803   2021.03( ISSN:1860-7179

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/cmdc.202000656

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  • Tumor Growth Suppression With Novel Intra-arterial Chemotherapy Using Epirubicin-entrapped Water-in-oil-in-water Emulsion In Vivo Reviewed

    Hironobu Yanagie, Takashi Fujino , Masashi Yanagawa, Toshimitsu Terao, Takashi Imagawa, Mitsuteru Fujihara, Yasuyuki Morishita, Ryouji Mizumachi, Yuuji Murata, Novriana Dewi, Yuuya Ono, Ichiro Ikushima, Koji Seguchi, Masashi Nagata, Yasumasa Nonaka, Yoshitaka Furuya, Tomoyuki Hisa, Takeshi Nagasaki, Kazuhiko Arimori, Tadao Nakashima, Takumichi Sugihara, Kazuhiro Kakimi, Minoru Ono, Jun Nakajima, Masazumi Eriguchi, Shushi Higashi, Hiroyuki Takahashi

    In Vivo   35 ( 1 )   239 - 248   2021.02

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    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

  • Cancer-Targeting Hyaluronic Acid/Carboranyl Pyrene Complex for Boron Neutron Capture Therapy Reviewed

    2021

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    Publishing type:Research paper (bulletin of university, research institution)   Kind of work:Joint Work  

  • Mechanism Toward Turn‐on of Polysaccharide–Porphyrin Complexes for Fluorescence Probes and Photosensitizers in Photodynamic Therapy in Living Cells Reviewed

    Shodai Hino, Rikushi Funada, Kouta Sugikawa, Riku Kawasaki, Kazuya Koumoto, Toshio Suzuki, Takeshi Nagasaki, and Atsushi Ikeda

    ChemMedChem   16   793 - 803   2020.10

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  • Improved Stability and Photodynamic Activity of Water-Soluble 5,15-Diazaporphyrins Incorporated in beta-(1,3-1,6)-d-Glucan with On-Off Switch Reviewed

    Hino Shodai, Satake Shuhei, Shinmori Hideyuki, Kawabata Shigeki, Koumoto Kazuya, Suzuki Toshio, Nagasaki Takeshi, Sugikawa Kouta, Kawasaki Riku, Ikeda Atsushi

    CHEMISTRY-AN ASIAN JOURNAL   15 ( 3 )   365 - 370   2020.02( ISSN:1861-4728

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/asia.201901582

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  • Preparation and Characterization of a Novel Bispecific Antibody That Targets Her2 and BSH for Boron Neutron Capture Therapy Reviewed

    KURNS Progress Report 2019   2020

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    Publishing type:Research paper (bulletin of university, research institution)   Kind of work:Joint Work  

  • Turn-on fluorescence and photodynamic activity of beta-(1,3-1,6)-d-glucan-complexed porphyrin derivatives inside HeLa cells Reviewed

    Hino Shodai, Funada Rikushi, Sugikawa Kouta, Koumoto Kazuya, Suzuki Toshio, Nagasaki Takeshi, Ikeda Atsushi

    PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES   18 ( 12 )   2854 - 2858   2019.12( ISSN:1474-905X

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1039/c9pp00208a

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  • Formation of beta-(1,3-1,6)-D-glucan-complexed [70]fullerene and its photodynamic activity towards macrophages (vol 15, pg 1990, 2017) Reviewed

    Ikeda Atsushi, Akiyama Motofusa, Sugikawa Kouta, Koumoto Kazuya, Kagoshima Yuta, Li Jiawei, Suzuki Toshio, Nagasaki Takeshi

    ORGANIC & BIOMOLECULAR CHEMISTRY   15 ( 45 )   9734 - 9734   2017.12( ISSN:1477-0520

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1039/c7ob90179h

  • Water Solubilization of Fullerene Derivatives by beta-(1,3-1,6)-D-Glucan and Their Photodynamic Activities toward Macrophages Reviewed

    Ikeda Atsushi, Iizuka Tatsuya, Maekubo Naotake, Nobusawa Kazuyuki, Sugikawa Kouta, Koumoto Kazuya, Suzuki Toshio, Nagasaki Takeshi, Akiyama Motofusa

    CHEMISTRY-AN ASIAN JOURNAL   12 ( 10 )   1069 - 1074   2017.05( ISSN:1861-4728

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/asia.201700182

  • Formation of β-(1,3-1,6)-d-glucan-complexed [70]fullerene and its photodynamic activity towards macrophages. Reviewed

    Ikeda A, Akiyama M, Sugikawa K, Koumoto K, Kashijima Y, Li J, Suzuki T, Nagasaki T

    Organic & biomolecular chemistry   15 ( 9 )   1990 - 1997   2017.03( ISSN:1477-0520

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1039/c6ob02747d

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  • Lipid-membrane-incorporated arylboronate esters as agents for boron neutron capture therapy Reviewed

    Ueda Masafumi, Ashizawa Kengo, Sugikawa Kouta, Koumoto Kazuya, Nagasaki Takeshi, Ikeda Atsushi

    ORGANIC & BIOMOLECULAR CHEMISTRY   15 ( 7 )   1565 - 1569   2017.02( ISSN:1477-0520

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1039/c6ob02142e

  • Improved isolation procedure for shikonin from the root of the Chinese medicinal plant Lithospermum erythrorhizon and its solubilization with cyclodextrins Reviewed

    Hideki Azuma,* Jiawei Li, Ryota Youda, Toshio Suzuki, Kazuhide Miyamoto, Taizo Taniguchi, Takeshi Nagasaki

    J. Appl. Res. Med. Arom Plants   3 ( 2 )   58 - 63   2016

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    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

  • Anti-inflammatory effect of water-soluble complex of 1 '-acetoxychavicol acetate with highly branched beta-1,3-glucan on contact dermatitis Reviewed

    Li Jiawei, Aizawa Yui, Hiramoto Keiichi, Kasahara Emiko, Tsuruta Daisuke, Suzuki Toshio, Ikeda Atsushi, Azuma Hideki, Nagasaki Takeshi

    BIOMEDICINE & PHARMACOTHERAPY   69   201 - 207   2015.02( ISSN:0753-3322

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.biopha.2014.11.026

  • Anti-inflammatory effect of water-soluble complex of 1’-acetoxychavicol acetate with highly branched -1,3-glucan on contact dermatitis

    Jiawei Li , Yui Aizawa, Keiichi Hiramoto, Emiko Kasahara, Daisuke Tsuruta, Toshio Suzuki, Atsushi Ikeda, Hideki Azuma

    Biomed. Biopharmacother.   69   201 - 207   2015.02

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  • Evaluation of Biocompatible Polylysine Bearing BSH as a Polymeric Agent for Boron Neutron Capture Therapy

    R. Kawasaki, M. Sakuramoto, M. Kirihata, K. Ono, S. Masunaga, Y. Sakurai

    KURRI Progress Report 2013   281   2014.10( ISSN:0919-1038

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    Publishing type:Research paper (bulletin of university, research institution)  

  • Hypoxia-induced Factor (HIF)-1α Inhibition and Metastasis Suppression with BNCT by Using Kojic Acid Modified o-Carborane

    R. Kawasaki, M. Sakuramoto, S. Iizuka, M. Kirihata, Y. Hattori, S. Masunaga,Y. Sakurai

    KURRI Progress Report 2013   124   2014.10( ISSN:0919-1038

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  • ホウ素中性子捕捉療法剤としての含有ホウ素希土類酸化物 Reviewed

    長崎 健

    化学工業   65   512 - 517   2014

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    Publishing type:Research paper (scientific journal)  

  • Tumor growth suppression by gadolinium-neutron capture therapy using gadolinium-entrapped liposome as gadolinium delivery agent Reviewed

    Dewi Novriana, Yanagie Hironobu, Zhu Haito, Demachi Kazuyuki, Shinohara Atsuko, Yokoyama Kazuhito, Sekino Masaki, Sakurai Yuriko, Morishita Yasuyuki, Iyomoto Naoko, Nagasaki Takeshi, Horiguchi Yukichi, Nagasaki Yukio, Nakajima Jun, Ono Minoru, Kakimi Kazuhiro, Takahashi Hiroyuki

    BIOMEDICINE & PHARMACOTHERAPY   67 ( 6 )   451 - 457   2013.07( ISSN:0753-3322

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.biopha.2012.11.010

  • Mechanism Involved in Tumor Tissue of Colon 26 Carcinoma - Bearing Mice Irradiated with Neutron in the Presence of BSH - Appended Polyamine

    Takeshi Nagasaki, Riku Kawasaki , Masashi Sakuramoto, Hideki Azuma, et al.

    CO6   2013

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    Publishing type:Research paper (bulletin of university, research institution)  

  • Kojic Acid - Appended Carorane/Hydroxypropyl-beta- Cyclodextrin Complex for BNCT of Murine Melanoma

    Riku Kawasaki, Takeshi Nagasaki , Jiawei Li , Hideki Azuma et al.

    KURRI Progress Report   PR6-6   2013

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    Publishing type:Research paper (bulletin of university, research institution)  

  • HVJ-E/importin-beta hybrid vector for overcoming cytoplasmic and nuclear membranes as double barrier for non-viral gene delivery Reviewed

    Kawazu Takeshi, Kanzaki Hiroyuki, Uno Atsushi, Azuma Hideki, Nagasaki Takeshi

    BIOMEDICINE & PHARMACOTHERAPY   66 ( 7 )   519 - 524   2012.10( ISSN:0753-3322

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.biopha.2012.02.005

  • HVJ-E/importin-b hybrid vector for overcoming cytoplasmic and nuclear membranes as double barrier for non-viral gene delivery Reviewed

    Takeshi Kawazu, Hiroyuki Kanzaki, Atsushi Uno, Hideki Azuma, Takeshi Nagasaki

    Elsevier   66 ( 7 )   519 - 524   2012.07

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    Authorship:Corresponding author   Publishing type:Research paper (scientific journal)   Kind of work:Joint Work   International / domestic magazine:International journal  

  • Protein recognition of hetero-/homoleptic ruthenium(II) tris(bipyridine)s for alpha-chymotrypsin and cytochrome c Reviewed

    Yamaguchi Yoshinobu, Kato Nobuo, Azuma Hideki, Nagasaki Takeshi, Ohkanda Junko

    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS   22 ( 6 )   2354 - 2358   2012.03( ISSN:0960-894X

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.bmcl.2011.12.087

  • Quantitative comparison between poly(L-arginine) and poly(L-lysine) at each step of polyplex-based gene transfection using a microinjection technique

    Tomoko Hashimoto, Takeshi Kawazu, Takeshi Nagasaki, Akira, Murakami, Tetsuji Yamaoka

    Sci. Technol. Adv. Mater.   13 ( 1 )   2012.03

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    Publishing type:Research paper (scientific journal)  

  • Protein Recognition of Hetero-/Homoleptic Ruthenium(II) Tris(bipyridine)s for -Chymotrypsin and Cytochrome c

    Yoshinobu Yamaguchi, Nobuo Kato, Hideki Azuma, Takeshi Nagasaki and Junko Ohkanda

    Bioorg. Med. Chem. Lett.   22 ( 6 )   2354 - 2358   2012.03

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    Publishing type:Research paper (scientific journal)  

  • Quantitative comparison between poly(L-arginine) and poly(L-lysine) at each step of polyplex-based gene transfection using a microinjection technique Reviewed

    Hashimoto Tomoko, Kawazu Takeshi, Nagasaki Takeshi, Murakami Akira, Yamaoka Tetsuji

    SCIENCE AND TECHNOLOGY OF ADVANCED MATERIALS   13 ( 1 )   2012.02( ISSN:1468-6996

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1088/1468-6996/13/1/015009

  • Kojic Acid-Appended Carorane/Hydroxypropyl-beta-Cyclodextrin Complex: A Novel Boron Carrier for Melanoma Targeting

    2012

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    Publishing type:Research paper (bulletin of university, research institution)  

  • Intracellular Distribution of BSH-Appended Polyamine at Tumor Tissue of Colon 26 Carcinoma-Bearing Mice

    KURRI Progress Report 2011   2012

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    Publishing type:Research paper (bulletin of university, research institution)  

  • Tumor Accumulation of e-Poly-Lysines-Based Polyamines Conjugated with Boron Clusters

    Masayuki Umano, Kazuhiro Uechi, Takatoshi Uriuda, Sayuri Murayama, Hideki Azuma, Takeshi Nagasaki et al.

    Applied Radiation and Isotopes   69 ( 12 )   1765 - 1767   2011.12

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    Publishing type:Research paper (scientific journal)  

  • Tumor accumulation of epsilon-poly-lysines-based polyamines conjugated with boron clusters Reviewed

    Umano Masayuki, Uechi Kazuhiro, Uriuda Takatoshi, Murayama Sayuri, Azuma Hideki, Shinohara Atsuko, Liu Young, Ono Koji, Kirihata Mitsunori, Yanagie Hironobu, Nagasaki Takeshi

    APPLIED RADIATION AND ISOTOPES   69 ( 12 )   1765 - 1767   2011.12( ISSN:0969-8043

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.apradiso.2011.02.048

  • Lateral phase separation in tense membranes

    Tsutomu Hamada, Yuko Kishimoto, Takeshi Nagasaki and Masahiro Takagi

    Soft Matter   7 ( 19 )   9061 - 9068   2011.10

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    Publishing type:Research paper (scientific journal)  

  • 関節リウマチへの適応を目指した免疫細胞選択的PDT薬剤デリバリーシステムの開発 Reviewed

    長崎 健, 鹿子嶋 祐太, 東 秀紀, 脇谷 滋之, 池田 篤志

    日本レーザー医学会誌 = The Journal of Japan Society for Laser Medicine   32 ( 2 )   2011.08( ISSN:02886200

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    Publishing type:Research paper (scientific journal)  

    CiNii Article

  • Biological activity of water-soluble inclusion complexes of 1 '-acetoxychavicol acetate with cyclodextrins Reviewed

    Azuma Hideki, Aizawa Yui, Higashitani Nao, Tsumori Takashi, Kojima-Yuasa Akiko, Matsui-Yuasa Isao, Nagasaki Takeshi

    BIOORGANIC & MEDICINAL CHEMISTRY   19 ( 12 )   3855 - 3863   2011.06( ISSN:0968-0896

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    DOI: 10.1016/j.bmc.2011.04.038

  • Biological activity of water-soluble inclusion complexes of 1'-acetoxychavicol acetate with cyclodextrins

    Hideki Azuma, Yui Aizawa, Nao Higashitani, Takashi Tsumori, Akiko Kojima-Yuasa, Isao Matsui-Yuasa and Takeshi Nagasaki

    Bioorg. Med. Chem.   19 ( 12 )   3855 - 3863   2011.06

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  • Ultrasound-mediated Transfection with Liposomal Bubbles Delivers Plasmid DNA Directly into Nucleus Reviewed

    Kawazu Takeshi, Hakamada Kazumi, Oda Yusuke, Miyake Jun, Maruyama Kazuo, Nagasaki Takeshi

    The Chemical Society of Japan CHEMISTRY LETTERS   40 ( 3 )   298 - 299   2011.03( ISSN:0366-7022

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    Transfection using ultrasound exposure in the presence of nanobubbles can overcome an important barrier for nonviral gene delivery, that is entering the nucleus without cell division. The monitoring of the relationship between fluorescent protein expression and cell division reveals that ultrasound-mediated transfection with liposomal bubbles is independent on the disappearance of nuclear membrane at mitosis.

    DOI: 10.1246/cl.2011.298

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  • Photochemical controlof membrane raft organization

    Soft Matter   7   220 - 224   2011

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  • Preparation and antitumor activity of water-soluble inclusion complexes of cyclodextrins with 1'-Acetoxychavicol Acetate Reviewed

    Azuma Hideki, Aizawa Yui, HIgashitani Nao, Kojima Akiko, Nagasaki Takeshi

    Association of Research for Host-Guest and Supramolecular Chemistry, Abstracts of Papers: Host-Guest Chemistry Symposium   2011 ( 0 )   33 - 33   2011

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    DOI: 10.14916/hgsupra.2011.0.33.0

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  • Photochemical control of membrane raft organization Reviewed

    Hamada Tsutomu, Sugimoto Ryoko, Nagasaki Takeshi, Takagi Masahiro

    SOFT MATTER   7 ( 1 )   220 - 224   2011( ISSN:1744-683X

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    DOI: 10.1039/c0sm00797h

  • Lateral phase separation in tense membranes Reviewed

    Hamada Tsutomu, Kishimoto Yuko, Nagasaki Takeshi, Takagi Masahiro

    SOFT MATTER   7 ( 19 )   9061 - 9068   2011( ISSN:1744-683X

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    DOI: 10.1039/c1sm05948c

  • Membrane Disk and Sphere: Controllable Mesoscopic Structures for the Capture and Release of a Targeted Object Reviewed

    Hamada Tsutomu, Sugimoto Ryoko, Vestergaard Mun'delanji C., Nagasaki Takeshi, Takagi Masahiro

    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY   132 ( 30 )   10528 - 10532   2010.08( ISSN:0002-7863

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    DOI: 10.1021/ja103895b

  • Enhanced internalization and endosomal escape of dual-functionalized poly(ethyleneimine)s polyplex with diphtheria toxin T and R domains Reviewed

    Kakimoto Shinji, Tanabe Toshizumi, Azuma Hideki, Nagasaki Takeshi

    BIOMEDICINE & PHARMACOTHERAPY   64 ( 4 )   296 - 301   2010.04( ISSN:0753-3322

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    DOI: 10.1016/j.biopha.2009.06.017

  • アポトーシスカクテル併用中性子捕捉療法用ホウ素デリバリーシステムの開発 Reviewed

    長崎 健

    (公財)鈴木謙三記念医科学応用研究財団 医科学応用研究財団研究報告   27   110 - 115   2010.02( ISSN:0914-5117

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    著者等は、ホウ素中性子捕捉療法(BNCT)をサポートするアポトーシスカクテル併用型BNCTのためのデリバリーシステム開発を目的に研究を行っている。これまでに、セラミド化合物のアポトーシス活性を増大させるケトセラミドの合成ならびにその機序に関する知見を得ている。また、タイショウガから単離された1'-Acetoxychavicol acetate(ACA)がアポトーシス誘導能を有することを明らかにした。アポトーシス制御因子Mcl-1に対してsiRNAが有効であることは既に多くの研究者によって報告されている。高いアポトーシス誘導作用をもつケトセラミドとACAに加え、Mcl-1に対するsiRNAをアポトーシスカクテルとしてBNCTに併用するためには、基本となるホウ素キャリアーの高い腫瘍集積性が必要である。そこで今回、安全性の高い天然ポリアミンであるε-ポリ-リジンを用いた腫瘍集積性高分子型ホウ素キャリアーの創製を行い、腫瘍選択的なホウ素キャリアーを作ることができたので報告した。

  • Membrane disc and sphere:controllable mesoscopic structures for the capture and release of a targeted object

    J. Am. Chem. Soc.   132   10528 - 10532   2010

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  • Enhanced internalization and endosomal escape of dual-functionalized poly(ethyleneimine)s polyplex with Diphtheria Toxin T and R domains

    Biomed. Biopharmacother.   64 ( 4 )   296 - 301   2010

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  • Self-Assembly and Cellular Uptake of Degradable and Water-Soluble Polyperoxides Reviewed

    Fujioka Tamami, Taketani Shuji, Nagasaki Takeshi, Matsumoto Akikazu

    BIOCONJUGATE CHEMISTRY   20 ( 10 )   1879 - 1887   2009.10( ISSN:1043-1802

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    DOI: 10.1021/bc9001618

  • Development of epirubicin entrapped WOW emulsion by double emulcification technique to arterial-injection-chemotherapy for hepatocellular carcinoma Reviewed

    Yanagie Hironobu, Morishita Yasuyuki, Nishimura Ryohei, Kakimi Kozuhiro, Sugiyama Hirotaka, Takamoto Shinichi, Higashi Shyushi, Ikushima Ichiro, Arimori Kazuhiko, Nagata Masashi, Nagasaki Takeshi, Imagawa Takashi, Nakashima Tadao, Terao Toshimitsu, Eriguchi Masazumi

    CANCER RESEARCH   69   2009.05( ISSN:0008-5472

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  • The Significance and Attempt to Establish the Intracellular Targeting on Gene Delivery System Reviewed

    KAKIMOTO Shinji, NAGASAKI Takeshi

    58 ( 3 )   133 - 136   2009.03( ISSN:04541138

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  • Reversible Control of Exo- and Endo-Budding Transitions in a Photosensitive Lipid Membrane Reviewed

    Ishii Ken-ichi, Hamada Tsutomu, Hatakeyama Masaomi, Sugimoto Ryoko, Nagasaki Takeshi, Takagi Masahiro

    CHEMBIOCHEM   10 ( 2 )   251 - 256   2009.01( ISSN:1439-4227

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    DOI: 10.1002/cbic.200800482

  • The conjugation of diphtheria toxin T domain to poly(ethylenimine) based vectors for enhanced endosomal escape during gene transfection Reviewed

    Kakimoto Shinji, Hamada Tsutomu, Komatsu Yuuki, Takagi Masahiro, Tanabe Toshizumi, Azuma Hideki, Shinkai Seiji, Nagasaki Takeshi

    BIOMATERIALS   30 ( 3 )   402 - 408   2009.01( ISSN:0142-9612

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    DOI: 10.1016/j.biomaterials.2008.09.042

  • Self-Assembly and Cellular Uptake of Degradable and Water-Soluble Polyperoxides

    Bioconjug. Chem.   20 ( 10 )   1879 - 1887   2009

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  • Cytochrome c-binding "proteo-dendrimers" as a new type of apoptosis inhibitors working in HeLa cells system Reviewed

    Azuma Hideki, Yoshida Yuuka, Paul Dharam, Shinoda Satoshi, Tsukube Hiroshi, Nagasaki Takeshi

    Association of Research for Host-Guest and Supramolecular Chemistry, Abstracts of Papers: Host-Guest Chemistry Symposium   2009 ( 0 )   13 - 13   2009

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    DOI: 10.14916/hgsupra.2009.0.13.0

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  • Cytochrome c-binding "proteo-dendrimers" as new types of apoptosis inhibitors working in HeLa cell systems Reviewed

    Azuma Hideki, Yoshida Yuuka, Paul Dharam, Shinoda Satoshi, Tsukube Hiroshi, Nagasaki Takeshi

    ORGANIC & BIOMOLECULAR CHEMISTRY   7 ( 8 )   1700 - 1704   2009( ISSN:1477-0520

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    DOI: 10.1039/b900154a

  • Target-selective vesicle fusion system with pH-selectivity and responsiveness Reviewed

    Kashiwada Ayumi, Tsuboi Mana, Mizuno Toshihisa, Nagasaki Takeshi, Matsuda Kiyomi

    SOFT MATTER   5 ( 23 )   4719 - 4725   2009( ISSN:1744-683X

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    DOI: 10.1039/b909503a

  • The conjugation ofdiphtheria toxin T domain to poly(ethylenimine)based vectors for enhanced endosomal escape during gene transfection.

    Biomaterials   30 ( 3 )   402 - 408   2009

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  • Reversible Controlof Exo- and Endo-BuddingTransitions in a Photosensitive Lipid Membrane.

    ChemBioChem   10 ( 2 )   251 - 256   2009

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  • Cytochrome c-bionding"proteo-dendrimers" as new types of apoptosis inhibitors working in HeLa cell systems

    Org. Biomol. Chem.   7   1700 - 1704   2009

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  • Target-selective vesicle fusion system with pH-selectivity and responsiveness

    Soft Matter   5   4719 - 4725   2009

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  • Photoresponsive polymeric materials for drug delivery systems : double targeting with photoresponsive polymers Reviewed

    NAGASAKI Takeshi

    Drug delivery system   23 ( 6 )   637 - 643   2008.11( ISSN:09135006

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  • 核内移行因子を組み込んだ遺伝子キャリアーシステム Reviewed

    長崎 健

    Drug delivery system   23 ( 3 )   2008.05( ISSN:09135006

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  • SF-096-2 WOWエマルションを用いた原発性肝癌に対する肝動注療法の基礎的検討(第108回日本外科学会定期学術集会) Reviewed

    柳衛 宏宣, 東 秀史, 生嶋 一朗, 森下 保幸, 西村 亮平, 永田 奨司, 長崎 健, 中島 忠夫, 今川 昴, 有森 和彦, 高橋 浩之, 江里口 正純, 高本 眞一

    一般社団法人日本外科学会 日本外科学会雑誌   109 ( 2 )   2008.04( ISSN:03014894

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  • Diphtheria toxin T domain-conjugated pei polyplex for enhanced trantection via elevated endosomal escape Reviewed

    Kakimoto Shinji, Nagasaki Takeshi

    JOURNAL OF GENE MEDICINE   10 ( 4 )   463 - 464   2008.04( ISSN:1099-498X

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  • Isothiouronium-based amphiphilic gold nanoparticles with a colorimetric response to hydrophobic anions in water: a new strategy for fluoride ion detection in the presence of a phenylboronic acid Reviewed

    Minami Tsuyoshi, Kaneko Kenji, Nagasaki Takeshi, Kubo Yuji

    TETRAHEDRON LETTERS   49 ( 3 )   432 - 436   2008.01( ISSN:0040-4039

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    DOI: 10.1016/j.tetlet.2007.11.120

  • Intracellular uptake and photodynamic activity of water-soluble [60]and [70]fullerenes incorporated in liposomes.

    Chem. Eur. J.   14 ( 29 )   8892 - 8897   2008

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  • Intracellular Uptake and Photodynamic Activity of Water-Soluble [60]- and [70]Fullerenes Incorporated in Liposomes Reviewed

    Doi Yuki, Ikeda Atsushi, Akiyama Motofusa, Nagano Mai, Shigematsu Tamami, Ogawa Takuya, Takeya Tatsuo, Nagasaki Takeshi

    CHEMISTRY-A EUROPEAN JOURNAL   14 ( 29 )   8892 - 8897   2008( ISSN:0947-6539

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    DOI: 10.1002/chem.200801090

  • Photoresponsive polymeric materials for drug delivery systems: double targeting with photo-responsive polymers:double targeting with photoresponsive polymers Reviewed

    Nagasaki Takeshi

    THE JAPAN SOCIETY OF DRUG DELIVERY SYSTEM, Drug Delivery System   23 ( 6 )   637 - 643   2008( ISSN:0913-5006

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    Photoresponsive polymeric materials are promising not only for cell-targeting <I>in vivo</I>, but also for intracellular navigations such as the internalization, the endosomal escape, and the nuclear import. Furthermore, the controlled release as well as the activation of drugs is caused by the photoresponsive delivery. Finally, such photoresponsive polymeric system can pave the way for double targeting of drugs resulting in temporal and spatial delivery. The photoresponsive synchronization of biocompatible materials and novel photo-irradiating apparatus might bring a various happiness to the refractory patients in near future.

    DOI: 10.2745/dds.23.637

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  • Synthesis of amphiphilic isothiouronium-capped gold nanoparticles and a new strategy for fluoride ion detection Reviewed

    Minami Tsuyoshi, Kaneko Kenji, Nagasaki Takeshi, Kubo Yuji

    Association of Research for Host-Guest and Supramolecular Chemistry, Abstracts of Papers: Host-Guest Chemistry Symposium   2008 ( 0 )   69 - 69   2008

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    DOI: 10.14916/hgsupra.2008.0.69.0

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  • Isothiouronium-based amphiphilic gold nanoparticles with a colorimetric response to hydrophobic anions in water: a new strategy for fluoride ion detection in the presence of a phenylboronic acid

    Tetrahedron Lett.   49 ( 3 )   432 - 436   2008

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  • Schizophyllan, beta-1,3-glucan,-oligoamine conjugates as non-viral vector Reviewed

    Nagasaki Takeshi, Uno Atsushi, Koumoto Kazuya, Sakurai Kazuo, Shinkai Seiji

    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY   234   2007.08( ISSN:0065-7727

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  • In vitro gene delivery to HepG2 cells using galactosylated 6-amino-6-deoxychitosan as a DNA carrier Reviewed

    Satoh Taku, Kakimoto Shinji, Kano Hiroshi, Nakatani Mika, Shinkai Seiji, Nagasaki Takeshi

    CARBOHYDRATE RESEARCH   342 ( 11 )   1427 - 1433   2007.08( ISSN:0008-6215

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    DOI: 10.1016/j.carres.2007.04.016

  • The concept of molecular machinery is useful for design of stimuli-responsive gene delivery systems in the mammalian cell Reviewed

    Nagasaki Takeshi, Shinkai Seiji

    JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY   58 ( 3-4 )   205 - 219   2007.08( ISSN:1388-3127

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    DOI: 10.1007/s10847-007-9303-6

  • Dual-ligand effect of transferrin and transforming growth factor alpha on polyethyleneimine-mediated gene delivery Reviewed

    Kakimoto Shinji, Moriyama Tetsuji, Tanabe Toshizumi, Shinkai Seiji, Nagasaki Takeshi

    JOURNAL OF CONTROLLED RELEASE   120 ( 3 )   242 - 249   2007.07( ISSN:0168-3659

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    DOI: 10.1016/j.jconrel.2007.05.001

  • Delivery of Antisense Oligonucleotides to Nuclear Telomere RNA by Use of a Complex between Polysaccharide and Polynucleotide Reviewed

    Minari Jusaku, Kubo Takanori, Ohba Hideki, SHIMADA Naohiko, TAKEDA Yoich, KARINAGA Ryouji, ANADA Takahisa, KOUMOTO Kazuya, KAWAZU Takeshi, NAGASAKI Takeshi, SHINKAI Seiji, SAKURAI Kazuo

    Chemical Society of Japan Bulletin of the Chemical Society of Japan   80 ( 6 )   1091 - 1098   2007.06( ISSN:00092673

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  • Delivery of antisense oligonucleotides to nuclear telomere RNA by use of a complex between polysaccharide and polynucleotide Reviewed

    Minari Jusaku, Kubo Takanori, Ohba Hideki, Shimada Naohiko, Takeda Yoich, Karinaga Ryouji, Anada Takahisa, Koumoto Kazuya, Kawazu Takeshi, Nagasaki Takeshi, Shinkai Seiji, Sakurai Kazuo

    公益社団法人 日本化学会 BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN   80 ( 6 )   1091 - 1098   2007.06( ISSN:0009-2673

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    Telomerase, which is highly activated in neoplastic cells, can be a target for antisense therapy, and for that purpose, antisense oligonucleotides (AS ODNs) have to be effectively delivered into cellular nucleus where the target telomerase is present. The present work shows a new strategy to deliver AS ODNs to nucleus by use of a novel complex made from a natural polysaccharide schizophyllan (SPG) and AS ODNs. Nuclear transport is strictly regulated by the nuclear pore size and the related proteins. If the molecular weight of SPG is decreased, the SPG/AS ODN complex should be easily transported, although the stability of the complex decreases with a decrease in the molecular weight. We optimized the molecular weight of SPG to be 25 K. Furthermore, we attached importin-&beta; (a nuclear transport protein) to the side chain of SPG by use of a streptavidin&ndash;biotin interaction. When this complex was added to Jurkat cells, the telomerase activity was more suppressed than the naked dose, indicating that the importin-&beta; in the complex induced the nuclear transport of the complexed AS ODN and the AS ODN inhibited the telomerase. The present work shows a new methodology for nuclear anti-sense therapy that should be important in future anti-cancer therapies.

    DOI: 10.1246/bcsj.80.1091

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  • β-1,3-Glucan Schizophyllan Can Act as a One-dimensional Host to Arrange Icosahedral Carboranes Reviewed

    NUMATA Munenori, TAMESUE Shingo, NAGASAKI Takeshi, SAKURAI Kazuo, SHINKAI Seiji

    The Chemical Society of Japan Chemistry letters   36 ( 5 )   668 - 669   2007.05( ISSN:03667022

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    We here demonstrate that schizophyllan (SPG: one kind of β-1,3-glucans)/<I>m</I>-carborane nanocomposites can be easily created in a supramolecular manner by utilizing the unique wrapping capability of SPG. TEM observations revealed that incorporated <I>m</I>-carborane molecules adopt continuous one-dimensional (1-D) arrangement in the SPG hydrophobic cavity. We believe that the present system can provide a novel concept not only for the separation of carborane isomers and the construction of one-dimensional architectures but also for the new formulation of boron neutron capture therapy (BNCT) agents.

    DOI: 10.1246/cl.2007.668

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  • beta-1,3-glucan schizophyllan can act as a one-dimensional host to arrange icosahedral carboranes Reviewed

    Numata Munenori, Tamesue Shingo, Nagasaki Takeshi, Sakurai Kazuo, Shinkai Seiji

    CHEMISTRY LETTERS   36 ( 5 )   668 - 669   2007.05( ISSN:0366-7022

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  • Cross-Linked ε-Poly-L-Lysine with Low Toxicity for Highly Efficient Transfection Reviewed

    NAGASAKI Takeshi, UNO Atsushi, MURAOKA Hisashi, SHINKAI Seiji, NISHIDA Mamoru, FUKUSHI Hideaki, HIRAKI Jun

    Peptide science : proceedings of the ... Japanese Peptide Symposium   2006   2007.03( ISSN:13447661

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    CiNii Article

  • Dual-ligand effect of transferrin and transforming growth factor alpha on polyethyleneimine-mediated gene delivery.

    J. Control. Release   120 ( 3 )   242 - 249   2007

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  • β-1,3-Glucan Schizophyllan Can Act as a One-dimensional Host to Arrange Icosahedral Carboranes.

    Chem. Lett.   36 ( 5 )   668 - 669   2007

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  • Delivery of Antisense Oligonucleotides to Nuclear Telomere RNA by use of a Complex between Polysaccharide and Polynucleotide.

    Bull Chem. Soc. Jpn.   80 ( 6 )   1091 - 1098   2007

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  • In vitro gene delivery HepG2 cells using a galactosylated 6-amino-6-deoxychitosan as a DNA carrier.

    Carbohydr. Res.   342 ( 11 )   1427 - 1433   2007

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  • 6-Amino-6-deoxy-chitosan. Sequential chemical modifications at the C-6 positions of N-phthaloyl-chitosan and evaluation as a gene carrier Reviewed

    Satoh Taku, Kano Hiroshi, Nakatani Mika, Sakairi Nobuo, Shinkai Seiji, Nagasaki Takeshi

    CARBOHYDRATE RESEARCH   341 ( 14 )   2406 - 2413   2006.10( ISSN:0008-6215

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    DOI: 10.1016/j.carres.2006.06.019

  • Galactosylated 6-amino-6-deoxychitosan for gene delivery into hepatocytes Reviewed

    SATOH Taku, NAGASAKI Takeshi, KANO Hiroshi, NAKATANI Mika, SHINKAI Seiji

    12 ( 2 )   138 - 139   2006.07( ISSN:13409778

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  • Enhanced Nuclear Import and Transfection Efficiency by Disaccharide-Modified PEIs Reviewed

    Nagasaki Takeshi, Shiga Toshiki, Jinta Tomomi, Shinkai Seiji

    MOLECULAR THERAPY   13   S73 - S74   2006.05( ISSN:1525-0016

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  • Branched Polymer-Mediated Gene Delivery Reviewed

    SATOH Taku, NAGASAKI Takeshi

    The Society of Polymer Science, Japan, Kobunshi   55 ( 3 )   156 - 160   2006.03( ISSN:04541138

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    DOI: 10.1295/kobunshi.55.156

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  • 6-Amino-6-deoxy-chitosan. Sequential Chemical Modifications at the C-6 Positions of N-Phthaloyl-chitosan and Evaluation as a Gene Carrier.

    T. Satoh, H. Kano, M. Nakatani, N. Sakairi, S. Shinkai, and T. Nagasaki

    Carbohydr. Res.   341 ( 14 )   2406 - 2413   2006

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  • Linear double-stranded DNA that mimics an infective tail of virus genome to enhance transfection Reviewed

    Anada T, Karinaga R, Koumoto K, Mizu M, Nagasaki T, Kato Y, Taira K, Shinkai S, Sakurai K

    JOURNAL OF CONTROLLED RELEASE   108 ( 2-3 )   529 - 539   2005.11( ISSN:0168-3659

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    DOI: 10.1016/j.jconrel.2005.08.019

  • Cholesterol-appended beta-(1 -> 3)-D-glucan schizophylllan for antisense oligonucleotides delivery to enhance the cellular uptake Reviewed

    Koumoto K, Mizu M, Anada T, Nagasaki T, Shinkai S, Sakurai K

    The Chemical Society of Japan BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN   78 ( 10 )   1821 - 1830   2005.10( ISSN:0009-2673

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    Schizophyllan is a natural β-(1 → 3)-<FONT SIZE="-2">D</FONT>-glucan existing as a triple helix in water and as a single chain in dimethyl sulfoxide (DMSO), respectively. As we already reported, when a homo-polynucleotide is added to a schizophyllan solution, the single chain of schizophyllan forms a complex with the polynucleotide. One of the potential applications of this novel complex is an antisense-oligonucleotide (AS ODN) carrier. The present paper describes a modification technique that enables us to introduce a cholesterol group only to the side chain of schizophyllan. We prepared four cholesterol-appended schizophyllans with different modification levels. Using these compounds, we made complexes and carried out an in vitro antisense assay, administrating a phosphorothioate AS ODN to the several cell lines to depress their c-myb mRNA. When we used 2.2–2.3 mol % modified schizophyllan as the carrier, the antisense effect was most enhanced among others. The addition of β-cyclodextrin improved the complexation ability as well as the up-take for highly modified samples. Furthermore, the cytotoxicity for these modified schizophyllan samples was negligibly as small as the natural (unmodified) schizophyllan. The present work has thus clarified that schizophyllan can act as a new potential candidate for AS ODN carriers.

    DOI: 10.1246/bcsj.78.1821

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  • Reversible photoswitching in a cell-sized vesicle Reviewed

    Hamada T, Sato YT, Yoshikawa K, Nagasaki T

    LANGMUIR   21 ( 17 )   7626 - 7628   2005.08( ISSN:0743-7463

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    DOI: 10.1021/la050885y

  • Enhanced nuclear import and transfection efficiency of plasmid DNA using streptavidin-fused importin-beta Reviewed

    Nagasaki T, Kawazu T, Tachibana T, Tamagaki S, Shinkai S

    JOURNAL OF CONTROLLED RELEASE   103 ( 1 )   199 - 207   2005.03( ISSN:0168-3659

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.jconrel.2004.11.024

  • Morphological dynamics and transcription/translation reactions in cell-sized lipid vesicles Reviewed

    Hamada T, Sato Y, Nomura SM, Tsumoto K, Nagasaki T, Yoshikawa K

    BIOPHYSICAL JOURNAL   88 ( 1 )   238A - 238A   2005.01( ISSN:0006-3495

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  • Linear Double-Stranded DNA that Mimics an Infective Tail of Virus Genome to Enhance Transfection.

    J. Control. Release   108 ( 2-3 )   529 - 539   2005

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    Publishing type:Research paper (scientific journal)  

  • Reversible Photoswitching in a Cell-Sized Vesicle

    Langmuir   21   7626 - 7628   2005

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    Publishing type:Research paper (scientific journal)  

  • Enhanced nuclear import and transfection efficiency of plasmid DNA using streptavidin-fused importin-beta

    J. Controlled Release   103   199 - 207   2005

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    Publishing type:Research paper (scientific journal)  

  • Cholesterol-appended β-(1 3)-D-glucan schizophyllan for antisense oligonucleotides delivery to enhance the cellular uptake.

    Bull. Chem. Soc. Jpn.   78 ( 10 )   1821 - 1983   2005

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    Publishing type:Research paper (scientific journal)  

  • Chemically-modified polysaccharide schizophyllan for antisense oligonucleotides delivery to enhance the cellular uptake efficiency

    Biochimica et Biophysica Acta-General Subjects   1670   91 - 104   2004

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    Publishing type:Research paper (scientific journal)  

  • A Polysaccharide Carrier for Immunostimulatory CpG DNAs to Enhance Cytokine Secretion

    J. Am. Chem. Soc.   126 ( 27 )   8372 - 8373   2004

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    Publishing type:Research paper (scientific journal)  

  • Long-Term Expression with Cationic Polymer Derived from a Natural Polysaccharide: Schizophyllan

    Bioconjugate Chem.   15 ( 2 )   249 - 259   2004

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    Publishing type:Research paper (scientific journal)  

  • Enhanced Antisense Effect of Polysaccharide-polynucleotide Complexes by Preventing the Antisense Oligonucleotide from Binding to Proteins in the Culture Medium

    Bull. Chem. Soc. Jpn.   77 ( 6 )   1101 - 1110   2004

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    Publishing type:Research paper (scientific journal)  

  • 6-Amino-6-deoxychitosan. Preparation and Application as Plasmid Vector in COS-1 Cells.

    Chem. Lett.   33 ( 3 )   340 - 341   2004

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    Publishing type:Research paper (scientific journal)  

  • Photo-Enhancement of Transfection Efficiency witha Novel Azobenzene-Based Cationic Lipids

    Chemistry Letters   32 ( 1 )   88 - 89   2003

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    Publishing type:Research paper (scientific journal)  

  • Photoenhancement of Transfection Efficiency Using Novel Cationic Lipids Having a Photocleavable Spacer

    14 ( 3 )   513 - 516   2003

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    Publishing type:Research paper (scientific journal)  

  • Can Nuclear Localization Signals Enhance Nuclear Localization of Plasmid DNA?

    14 ( 2 )   282 - 286   2003

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    Publishing type:Research paper (scientific journal)  

  • Synthesis of a novel azobenzene-based trihydroxamate siderophore and photoregulation of its ferric complex structure

    41 ( 14 )   2411 - 2414   2000

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    Publishing type:Research paper (scientific journal)  

  • Microbial Growth Regulation Using Photoresponsive Siderophore

    ( 8 )   872 - 873   2000

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    Publishing type:Research paper (scientific journal)  

  • Synthesis of a Novel Water-Soluble Polyazobenzene Dendrimer and Photoregulation of Affinity Toward DNA

    Mol. Cryst. Liq. Cryst.   345   227 - 232   2000

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    Publishing type:Research paper (scientific journal)  

  • Photo-Regulative Transfection Using a Cationic Polyazobenzene Dendrimer

    Kobunshi Ronbunshu   57 ( 10 )   696 - 700   2000

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    Publishing type:Research paper (scientific journal)  

  • Sugar-Induced Stereoselectivity in the Fe3+-Complexation of Boronic Acid-Appended Trihydroxamate-Type Artificial Siderophores

    Supramol. Chem.   11 ( 4 )   301 - 314   2000

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    Publishing type:Research paper (scientific journal)  

  • Syntheses and Characterization of Photochromic Dendrimers lncluding a 1,3alternate Calix[4]arene as a Core and Azobenzene Moieties as Branches

    Chem. Lett.   ( 8 )   717   1997

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    Publishing type:Research paper (scientific journal)  

  • Effect of coexisting alkaline metal ions onthe extraction selectivity of lanthanide ions with calixarene carboxylate derivatives

    16 ( 10 )   1655 - 1661   1997

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    Publishing type:Research paper (scientific journal)  

  • Photochemically size-controllable dendrimers including a 1,3-alfernate calix[4]arene as a core and azobenzene moiefies asbranches

    Anales de Quimica 1nt. Ed.   93 ( 5 )   341 - 346   1997

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    Publishing type:Research paper (scientific journal)  

  • Extraction Behavior of Copper(II) Ion by Calixarene Carboxlate Derivatives Preorganized by Sodium Ion

    Solvent Extr. Ion Exch.   14 ( 3 )   459 - 478   1996

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    Publishing type:Research paper (scientific journal)  

  • Sugar Induced Color and Orientation Changes in a Cyanine Dye Bound to Boronic-Acid-Appended Poly(L-lysine)

    Tetrahedron Letter   36 ( 4 )   559 - 562   1995

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    Publishing type:Research paper (scientific journal)  

  • Design and Synthesis of a CD24D2-Symmetrial Hard-Soft Ditopic Metal Receptor by Calixarene-porphyrin Coupling

    Journal of Chemical Society ,Perkin Transaction 1   ( 15 )   1883 - 1888   1995

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    Publishing type:Research paper (scientific journal)  

  • Solvent Extraction of Trivalent Rare Earth Metal Ions with Carboxylate Derivatives of Calixarenes

    Analyfical Sciences   11   893 - 902   1995

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    Publishing type:Research paper (scientific journal)  

  • Sugar-induced Conformational Changes in Boronic Acid-appended Poly (L-and D-lysine)s and Sugar-controlled Orientation of a Cyanine dye on the Polymer

    Journal of Chemical Society ,Perkin Transaction 2   ( 10 )   1889 - 1894   1995

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    Publishing type:Research paper (scientific journal)  

  • Self-assembly of Tetracationic Amphiphiles Bearing Calix[4]arene core. Correlationbetween the Core Structure and the Aggregation Properties

    Journal of Chemical Society, Perkin Transaction 2   ( 4 )   679 - 683   1995

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    Publishing type:Research paper (scientific journal)  

  • Synthesis, Metal-binding Properties and Polypeptide Solubilization of"Crowned" Arborols

    Journal of Chemical Society, Perkin Transaction 1   ( 1 )   75 - 81   1994

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    Publishing type:Research paper (scientific journal)  

  • Influence of Added Saccharides on the Conformation of Boronic-Acid-Appended Poly(L-lysine). Attempts to Control a Helix-Coil Transition by Sugars((Multiple Authorship))

    Chemistry Letters   ( 10 )   1495 - 1498   1994

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    Publishing type:Research paper (scientific journal)  

  • Novel Chemical Modification of Myoglobin byan Alcohol-Responsive Phenylboronic Acid Function

    Chemistry Letters   ( 10 )   1945 - 1948   1994

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    Publishing type:Research paper (scientific journal)  

  • Calix[4]arene-Capped Tetraphenylporphyrin. Synthetic Approach to a Chiral Capped Porphyrin with Regular CD24D2 Symmetry

    Chemistry Letters   ( 6 )   989 - 992   1994

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    Publishing type:Research paper (scientific journal)  

  • Influence of Added Saccharides on the Conformation of Boronic-Acid-Appended Poly(L-lysine). Attempt to Control a Helix-Coil Transition by Sugars

    Chem. Lett.   ( 8 )   1495 - 1498   1994

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    Publishing type:Research paper (scientific journal)  

  • Molecular Design of Hard-Soft Ditopic Metal-Binding Sites on a Calix[4]arene Platform

    Tetrahedron Letter   35 ( 24 )   4157 - 4160   1994

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    Publishing type:Research paper (scientific journal)  

  • Thiadiphosphetane Disulfide as a Metal Extractant Which Shows High AgD1+D1 Selectivity

    Tetrahedron Letter   35 ( 34 )   6313 - 6316   1994

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    Publishing type:Research paper (scientific journal)  

  • Sugar Sensing Utilizing Aggregation Properties of Boronic-acid-appended Porphyrins and Metalloporphyrins

    Journal of Chemical Society, Perkin Transaction 2   ( 5 )   975 - 981   1994

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    Publishing type:Research paper (scientific journal)  

  • Attempts to Change the color of Dye Molecules by Saccharides

    Tetrahedron Letter   35 ( 14 )   2201 - 2204   1994

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    Publishing type:Research paper (scientific journal)  

  • Tailor-making of Desired Assemblies from Well-designed Monomers : Use of Calix[4]arene Comformers as Building Blocks

    Journal of Chemical Society, Perkin Transaction 1   ( 8 )   887 - 889   1993

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    Publishing type:Research paper (scientific journal)  

  • New Water-Soluble Calixarenes Modified with Amino Acids at the Upper Rim

    Recueil des Travaux Chimiques des Pays-Bas   112 ( 6 )   407 - 411   1993

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    Publishing type:Research paper (scientific journal)  

  • Sugar Sensing Utilizing Aggregation Properties of a Boronic-acid-appended Porphyrin

    Tetrahedron Letter   34 ( 39 )   6273 - 6276   1993

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    Publishing type:Research paper (scientific journal)  

  • Solvent Extraction of Trivalent Yttrium, Holmium, and Erbium by Novel Types of Acidic Organophosphonates

    Bulletin of Chemical Society of Japan   66 ( 9 )   2528 - 2538   1993

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    Publishing type:Research paper (scientific journal)  

  • Molecular Design of a Calix[6]arene-Based Super-Uranophile with CD23D2 Symmetry. High UOD22D2D12+D1 Selectivity in Solvent Extraction

    Chemistry Letters   ( 5 )   829 - 832   1993

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    Publishing type:Research paper (scientific journal)  

  • "Crowned" Arborols

    Journal of Chemical Society ChemicalCommunications   ( 8 )   608 - 609   1992

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    Publishing type:Research paper (scientific journal)  

  • Conformational Analysis of Calix[n]arenes with Chiral Substituents by Using Circular Dichroism

    Journal of Physical Organic Chemistry   5   699 - 710   1992

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    Publishing type:Research paper (scientific journal)  

  • Intercalation of a Trimethylammoniomethylated Calix[4]arene by Cu(II)-Montmorillonite

    Bulletin of Chemical Society of Japan   65 ( 9 )   2510 - 2513   1992

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    Publishing type:Research paper (scientific journal)  

  • Calixarene-Tetracyanoethylene Complexes. On the Selective Complexation with Calix[4]arene Conformers

    Tetrahedron   48 ( 6 )   1059 - 1070   1992

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    Publishing type:Research paper (scientific journal)  

  • Novel Conformational Isomerism of Water-Soluble Calix[4]arenes

    Tetrahedron   48 ( 5 )   797 - 804   1992

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    Publishing type:Research paper (scientific journal)  

  • Solvent Extraction on Transition Metal Cations by Calixarene-besed Cyclic Ligands

    Bulletin of Chemical Society of Japan   65 ( 2 )   471 - 475   1992

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    Publishing type:Research paper (scientific journal)  

  • Synthesis and Solvent Extraction Studies of Novel Clixarene-based Uranophiles Bearing Hydroxamic Groups

    Journal of Chemical Society Perkin Transactions 2   ( 7 )   1063 - 1066   1991

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    Publishing type:Research paper (scientific journal)  

  • A New Calix[6]arene-Based Uranophile with Phosphonate Groups as Ligands

    Bulletin of Chemical Society of Japan   64 ( 8 )   2575 - 2577   1991

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    Publishing type:Research paper (scientific journal)  

  • New Syntheses and Physical Properties of p-Alkylcalix[n]arenes

    Bulletin of Chemical Societyof Japan   64 ( 2 )   381 - 386   1991

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    Publishing type:Research paper (scientific journal)  

  • D113D1C NMR Relaxation Time Studies of Calixarenes and Their O-Methyl and Acyclic Analogs

    Chemistry Express   6 ( 7 )   491 - 494   1991

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    Publishing type:Research paper (scientific journal)  

  • Calixarene-Based Molecular Capsule

    Tetrahedron Letter   32 ( 38 )   5111 - 5114   1991

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    Publishing type:Research paper (scientific journal)  

  • Kinetic Studies of Calixarene-based Cyclic and Non-cyclic"Super-uranophiles"

    Journal of Chemical Society Perkin Transaction 2   ( 9 )   1325 - 1327   1991

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    Publishing type:Research paper (scientific journal)  

  • Synthesis and Solvent Extration Properties of a Novel Calixarene-based Uranophile Bearing Hydroxamate Groups

    Journal of Chemical Society Perkin Transaction 1   ( 9 )   2617 - 2618   1990

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    Publishing type:Research paper (scientific journal)  

  • Host-Guest Properties of New Water-Soluble Calixarenes Derived from p-(Chloromethyl) Calixarenes

    Journal of Organic Chemistry   54 ( 16 )   3766 - 3768   1989

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    Publishing type:Research paper (scientific journal)  

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Books and Other Publications

  • 超分子材料の設計と応用展開, 機能性食品素材b-グルカンの開発-機能性食品素材開発から医療材料への応用-

    鈴木利雄, 長﨑 健, 井戸垣秀聡( Role: Joint author)

    シーエムシー出版  2014.09 

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    Responsible for pages:14  

  • ひらく、ひらく「バイオの世界」14歳からの生物工学入門-遺伝子治療ってどうやるの?

    日本生物工学会 編( Role: Contributor)

    化学同人  2012.10 

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    Responsible for pages:2  

  • Ultrasound-mediated Transfection with Liposomal Bubbles Delivers Plasmid DNA Directly into Nucleu

    Takeshi Kawazu, Kazumi Hakamada, Yusuke Oda, Jun Miyake, Kazuo Maruyama, and Takeshi Nagasaki( Role: Joint author)

    Chem. Lett.  2011.03 

  • ファインケミカルシリーズ バイオ医薬の開発技術とシーズ-核酸医薬開発に欠かせないデリバリーテクノロジー(

    柿本 真司, 長﨑 健( Role: Contributor)

    シーエムシー出版  2009.03 

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    Responsible for pages:12  

  • Bottom-Up Nanofablication, Development of Molecular Machinery as Nonviral Vectors

    Tomomi Jinta, Takeshi Nagasaki( Role: Contributor)

    American Scientific Publishers  2009 

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    Responsible for pages:14  

  • 遺伝子医学MOOK別冊 絵で見てわかるナノDDS–マテリアルから見た治療・診断・予後・予防、ヘルスケア技術の最先端, DDSのための光応答性マテリアル

    長崎 健( Role: Contributor)

    メディカルドゥ  2007 

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    Responsible for pages:7  

  • Non-viral Gene Therapy: Gene Design and Derivery, 2.2 Active DNA Release from Complexes

    ( Role: Sole author)

    Springer-Verlag, Tokyo  2005  ( ISBN:4431251227

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    Book type:Scholarly book

  • Non-viral Gene Therapy: Gene Design and Derivery, 2.4 Active Transport of Exogenous Genes into the Nucleus

    ( Role: Joint author)

    Springer-Verlag, Tokyo  2005  ( ISBN:4431251227

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    Book type:Scholarly book

  • ゲルの安定化と機能性付与・次世代への応用開発-安全性の高い止血剤用ハイドロゲルの開発

    長﨑 健, 石橋謙一, 大畑建治( Role: Joint author)

    技術情報協会  2003.12 

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    Responsible for pages:7  

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MISC

  • Photoresponsive Gene Delivery System: Photoregulation of Intracellular Trafficking Using Photoresponsive Liposome Invited Reviewed

    Takeshi Nagasaki, Tsutomu Hamada

    Laser Society of Japan   45 ( 11 )   696 - 700   2017.11( ISBN:0387-0200

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    Publishing type:Article, review, commentary, editorial, etc. (scientific journal)   Kind of work:Joint Work  

    Since light as a stimulus can be controlled both temporally and spatially, photo-irradiation improves both the endosomal escape of exogenous DNA and DNA release from the complexes with carriers. When a photo-responsive cationic lipid formed a cell-sized giant vesicle, we observed the photo-isomerization effect of azobenzene on its shape change. Photoswitching the membrane line tension induced reversible transitions between a closed sphere and an opened disk with a bilayer pore. In a transfection experiment using a photoresponsive cationic lipid, UV irradiation improved the transfection efficiency. After the lipoplexes passed through the plasma membrane by endocytosis, trans to cis isomerization of azobenzene moiety destabilized the vesicle membrane, thus accelerating not only the membrane fusion of the photo-responsive lipid vesicles but also the endosomal escape of the exogenous DNA.

  • 体内で放射線を発生させる新規放射線療法のための無機ホウ素クラスターマテリアル

    -

    エヌ・ティー・エス   12 ( 5 )   34 - 39   2012.05

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    Publishing type:Article, review, commentary, editorial, etc. (other)   Kind of work:Single Work  

  • Evaluation of hyperbranched polyglycerol-graft-γ-cyclodextrin for neutron capture therapy Reviewed

    杉浦幸作, 板尾琴子, 金井大成, 櫻井良憲, 真田悠生, 増永慎一郎, 長崎健, 大谷亨

    シクロデキストリンシンポジウム講演要旨集   37th   2021

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    Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

    J-GLOBAL

  • Preparation and Characterization of a Novel Bispecific Antibody That Targets Her2 and BSH for Boron Neutron Capture Therapy Invited

    Taisei Kanai, Taro Tachibana, Takeshi Nakanishi, Takeshi Nagasaki, Mitsunori Kirihata, Yoshihide Hattori, Yu Sanada, Yoshinori Sakurai and Shin-ichiro Masunaga

    KURNS Progress Report 2019   2020.04

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    Publishing type:Rapid communication, short report, research note, etc. (bulletin of university, research institution)   Kind of work:Joint Work  

  • Photoresponsive Gene Delivery System: Photoregulation of Intracellular Trafficking Using Photoresponsive Liposome Reviewed

    Takeshi Nagasaki, Tsutomu Hamada

    Laser Society of Japan   45 ( 11 )   696 - 700   2017.11

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    Publishing type:Article, review, commentary, editorial, etc. (scientific journal)   Kind of work:Single Work  

    Since light as a stimulus can be controlled both temporally and spatially, photo-irradiation improves both the endosomal escape of exogenous DNA and DNA release from the complexes with carriers. When a photo-responsive cationic lipid formed a cell-sized giant vesicle, we observed the photo-isomerization effect of azobenzene on its shape change. Photoswitching the membrane line tension induced reversible transitions between a closed sphere and an opened disk with a bilayer pore. In a transfection experiment using a photoresponsive cationic lipid, UV irradiation improved the transfection efficiency. After the lipoplexes passed through the plasma membrane by endocytosis, trans to cis isomerization of azobenzene moiety destabilized the vesicle membrane, thus accelerating not only the membrane fusion of the photo-responsive lipid vesicles but also the endosomal escape of the exogenous DNA.

  • ホウ素中性子捕捉療法剤としての含ホウ素希土類酸化物 Invited

    冨田恒之, 長崎健

    化学工業   65 ( 7 )   512 - 517   2014.07

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    Publishing type:Article, review, commentary, editorial, etc. (other)   Kind of work:Joint Work  

  • 新規ホウ素含有ナノ粒子の開発とBNCTへの応用

    冨田恒之, 長崎 健

    Isotope News   67   451 - 457   2013

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    Publishing type:Article, review, commentary, editorial, etc. (other)  

  • 健康・医療用マテリアルとしてのβ-1,3-グルカン Reviewed

    鈴木利雄, 長崎 健

    機能材料   30 ( 9 )   54 - 62   2010

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  • 健康・医療用マテリアルとしてのβ-1,3-グルカン Invited

    鈴木利雄, 長崎 健

    機能材料   30 ( 9 )   54 - 62   2010

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    Publishing type:Article, review, commentary, editorial, etc. (other)   Kind of work:Joint Work  

  • 新規メカニズムで作用する抗アポトーシス剤 Invited

    長崎 健, 東 秀紀

    化学   64 ( 10 )   70 - 71   2009

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    Publishing type:Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)   Kind of work:Joint Work  

  • 細胞内ターゲティングの必要性とその試み Reviewed

    柿本真司, 長﨑 健

    高分子   58 ( 3 )   133 - 136   2009

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    Publishing type:Article, review, commentary, editorial, etc. (other)   Kind of work:Single Work  

  • 高分子遺伝子キャリアー材料–デンドリマーを用いた遺伝子送達技術– Invited

    長崎健

    未来材料   8 ( 2 )   50 - 55   2008

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    Publishing type:Article, review, commentary, editorial, etc. (other)   Kind of work:Single Work  

  • 核内移行因子を用いた遺伝子デリバリー Invited

    長崎健

    化学工業   59 ( 4 )   58 - 63   2008

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    Publishing type:Article, review, commentary, editorial, etc. (other)   Kind of work:Single Work  

  • 光応答性高分子材料-光応答性高分子によるダブルターゲティング Invited

    長﨑 健

    Drug Delivery System   23 ( 6 )   637 - 643   2008

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    Publishing type:Article, review, commentary, editorial, etc. (other)   Kind of work:Single Work  

  • The Concept of Molecular Machinery Is Useful for Design of Stimuli-Responsive Gene Delivery Systems in the Mammalian Cell.

    J. Incl. Phenom. Macrocycl. Chem.   58 ( 3-4 )   205 - 219   2007

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    Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 分岐高分子を用いる遺伝子デリバリーシステム

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    高分子   55 ( 3 )   156 - 160   2006

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    Publishing type:Article, review, commentary, editorial, etc. (other)   Kind of work:Single Work  

  • 第二世代に突入した合成ベクター

    -

    化学   57 ( 3 )   56 - 57   2002

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    Publishing type:Article, review, commentary, editorial, etc. (scientific journal)   Kind of work:Single Work  

  • シデロホアを利用した細菌へのドラッグデリバリー

    -

    化学   55 ( 6 )   59 - 60   2000( ISBN:0451-1964

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    Publishing type:Article, review, commentary, editorial, etc. (other)   Kind of work:Single Work  

  • デンドリマーを利用した遺伝子導入

    -

    化学   52 ( 6 )   65   1997

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    Publishing type:Article, review, commentary, editorial, etc. (other)   Kind of work:Single Work  

  • Extraction Behavior of Copper Ion by Calixarene Carboxylate Derivatives Preorganized by Sodium Ion((Multiple Authorship))

    Solvent Extraction and Ion Exchange   14 ( 3 )   459 - 478   1996

  • Applications of Calixarenes as Cyclic Oligomers

    Kobunshi High Polymers, Japan   42 ( 2 )   107   1993

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    Publishing type:Article, review, commentary, editorial, etc. (other)  

  • Development of Novel Ligands for Imaging Agents

    Chemistry   46 ( 3 )   208 - 209   1991

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    Publishing type:Article, review, commentary, editorial, etc. (other)  

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Presentations

  • 糖鎖抗体作製用の糖セラミド類の合成 Domestic conference

    竹林尚志, 東秀紀,長﨑健

    BioMedicaal Forum 2024  2023.12  大阪公立大学バイオ・メディカル・フォーラム

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    Presentation type:Poster presentation  

    Venue:堺市  

  • 4-((E)-3-Hydroxyprop-1-enyl)phenyl acetate 修飾ALAを基にした新規LAT1阻害化合物の開発 Domestic conference

    松枝蒼弥、東秀紀,長﨑健

    BioMedicaal Forum 2024  2023.12  大阪公立大学バイオ・メディカル・フォーラム

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    Presentation type:Poster presentation  

    Venue:堺市  

  • 交換反応を利用した疎水性ホウ素クラスター集積化エクソソームの開発とホウ素中性子捕捉療法への応用 Domestic conference

    大重彩乃,河崎陸,山名啓太,平野英寿,田畑杏梨, 坂東香里, 真田悠生, 櫻井良憲, 田中浩基, 鈴木実, 水田涼介,佐々木善浩,秋吉一成, 長崎健, 池田篤志

    BioMedicaal Forum 2024  2023.12  大阪公立大学バイオ・メディカル・フォーラム

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    Presentation type:Poster presentation  

    Venue:堺市  

  • マクロファージ極性制御剤とホウ素中性子捕捉療法の併用治療に関する研究 Domestic conference

    安川 直輝・坂東香里・高林直紀・近藤夏子・櫻井良憲・真田悠生・河崎 陸・長﨑 健

    BioMedicaal Forum 2024  2023.12  大阪公立大学バイオ・メディカル・フォーラム

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    Presentation type:Poster presentation  

    Venue:堺市  

  • ホウ素中性子捕捉療法のための腫瘍指向性窒化ホウ素ナノチューブの開発 Domestic conference

    山名啓太, 河崎陸,平野英寿,真田悠,東秀紀, 高田卓志, 櫻井良憲, 田中浩基, 児玉智基, 河本正次, 長崎健, 池田篤志

    第45回日本バイオマテリアル学会  2023.11  日本バイオマテリアル学会

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    Venue:神戸市  

  • 交換反応によるカルボラン集積イムノリポソームの調製と BNCT 応用 Domestic conference

    大重彩乃, 河崎陸,山名啓太,平野英寿,真田悠生, 坂東香里, 田畑杏梨, 田中浩基, 櫻井良憲, 鈴木実, 安原主馬, 西村智貴, 篠田渉, 長崎健, 池田篤志

    第45回日本バイオマテリアル学会  2023.11  日本バイオマテリアル学会

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    Venue:神戸市  

  • BSHとHer2に対する二重特異性抗体を用いたBNCT用ホウ素デリバリーシステム Invited Domestic conference

    長﨑 健・田畑 杏梨・坂東 香里・立花 太郎・中西 猛・河崎 陸 ・ 櫻井 良憲・田中 浩基・真田 悠生

    第72回高分子討論会  2023.09  高分子学会

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    Venue:高松市  

  • 抗BSHウサギ抗体のCDR領域配列解析と物性評価 Domestic conference

    吉田 伊吹・田畑杏梨・金井大成・立花 太郎・中西 猛・伊原寛一郎・長﨑 健・黒田大祐

    遺伝子・デリバリー研究会 第22回シンポジウム  2023.09  遺伝子・デリバリー研究会

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    Venue:大阪市  

  • シコニン含有b-1,3グルカンナノゲルのBPA-BNCTにおける併用効果 Domestic conference

    安川直輝・坂東香里・田畑杏里・近藤夏子・櫻井良憲・真田悠生・長﨑 健

    遺伝子・デリバリー研究会 第22回シンポジウム  2023.09  遺伝子・デリバリー研究会

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    Venue:大阪市  

  • 抗BSH抗体の獲得とCDR領域配列解析 Domestic conference

    吉田 伊吹、長崎 健

    第39回日本DDS学会学術集会  2023.07  日本DDS学会

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    Venue:千葉市  

  • ホウ素ナノ粒子のクラスターを集積させたハイブリッドナノゲルの創製とBNCT応用 Domestic conference

    河﨑 陸, 平野 英寿, 山名 啓太, 真田 悠生,櫻井 良憲, 長崎 健, 鈴木 実,佐々木 善浩, 秋吉 一成

    第19回日本中性子捕捉療法学会学術大会  2023.07  日本中性子捕捉療法学会

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    Venue:横浜市  

  • 酸化ホウ素ナノ粒子集積を高度に集積したハイブリッドナノゲルの創製とバイオ機能 Domestic conference

    河﨑 陸, 平野 英寿, 山名 啓太, 真田 悠生, 坂東 香里, 田畑 杏梨, 櫻井 良憲, 田中 浩基, 鈴木 実, 澤田 晋一, 佐々木 善浩, 秋吉 一成, 長崎 健, 池田 篤志

    第20回 ホスト-ゲスト・超分子化学シンポジウム  2023.06 

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    Venue:八王子市  

  • Sorbitol-releasing in situ gelling materials for treatment of myocardial infarction Domestic conference

    Hue LE THI, K. Fukazawa, T. Nagasaki, A. Mahara, T. Yamaoka

    2023.05 

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  • Development of organic-inorganic hybrid nanomaterials for boron neutron capture therapy Invited Domestic conference

    Riku Kawasaki・Keita Yamana・Hidetoshi Hirano・Ayano Oshige・Yu Sanada・Kaori Bando・Anri Tabata・Yoshinori Sakurai・Hiroki Tanaka・Minoru Suzuki・Shin-ichi Sawada・Yoshihiro Sasaki・Kazunari Akiyoshi・Takeshi Nagasaki・Atsushi Ikeda

    2023.05 

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  • Bispecific antibody against BSH and Her2 for Boron Neutron Capture Therapy Invited International conference

    T. Nagasaki, A. Tabata, T. Kanai, T. Tachibana, T. Nakanishi, R. Kawasaki, Y. Sakurai, Y. Sanada

    2023 Taiwan-Japan Neutron Capure Therapy Academic Conference of Elite  2023.03 

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  • 使える医療機器の開発を目指して:大切な特性と要らない特性 Domestic conference

    山岡 哲二、深澤 今日子、長﨑健

    日本バイオマテリアル学会関西ブロック 第17回若手研究発表会  2023.03  日本バイオマテリアル学会関西ブロック

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    Venue:堺市  

  • 高濃度オーラプテン水溶液の調製とその抗腫瘍効果に関する研究 Domestic conference

    宮尾 勇人、長﨑健

    BioMedical Forum 2023  2023.01  大阪公立大学バイオメディカルフォーラム

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    Venue:堺市  

  • β-1,3-グルカン/シコニンナノゲルの調製とその物性評価 Domestic conference

    坂東 香里、長﨑健

    BioMedical Forum 2023  2023.01  大阪公立大学バイオメディカルフォーラム

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    Venue:堺市  

  • 二重特異性抗体を用いたBNCTホウ素デリバリー Domestic conference

    田畑 杏梨、金井 大成・中西 猛・立花 太郎・真田 悠生・櫻井 良憲・長崎 健

    BioMedical Forum 2023  2023.01  大阪公立大学バイオメディカルフォーラム

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    Venue:堺市  

  • コウジ酸を利用したメラノーマに対しての薬物送達及び可視化可能なツールの開発 Domestic conference

    笹井 麻由、東秀紀,長﨑健

    BioMedical Forum 2023  2023.01  大阪公立大学バイオメディカルフォーラム

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    Venue:堺市  

  • 軟組織表面への接触で速やかに被膜化する癒着防止スプレーの開発 Domestic conference

    深澤 今日子、松井 直、長崎 健、山岡 哲二

    第44回日本バイオマテリアル学会  2022.11  日本バイオマテリアル学会

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    Venue:東京都江戸川区  

  • BSHとHer2に対する二重特異性抗体を用いたホウ素デリバリーとBNCT効果 Domestic conference

    田畑杏梨、金井大成、河﨑 陸、櫻井良憲、真田悠生、立花太郎、中西 猛、長﨑 健

    第44回日本バイオマテリアル学会  2022.11  日本バイオマテリアル学会

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    Venue:東京都江戸川区  

  • 心筋虚血の治療を目指したsorbitol self-releasing injectable hydrogel(Sorbitol self-releasing injectable hydrogel for the treatment of myocardial ischemia) Domestic conference

    Le Thi Hue, Fukazawa Kyoko, Mahara Atsushi, Nagasaki Takeshi, Yamaoka Tetsuji

    日本バイオマテリアル学会大会予稿集  2022.11  日本バイオマテリアル学会

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  • BSHとHer2に対する二重特異性抗体を用いたホウ素デリバリーとBNCT効果 Domestic conference

    長﨑 健、田畑杏梨、金井大成、河﨑 陸、櫻井良憲、真田悠生、立花太郎、中西 猛

    第18回日本中性子捕捉療法学会  2022.10  日本中性子捕捉療法学会

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    Venue:つくば市  

  • BSHとHer2に対する二重特異性抗体のBNCTホウ素送達ツールとしての評価 Domestic conference

    田畑杏梨、金井大成、河﨑 陸、櫻井良憲、真田悠生、立花太郎、中西 猛、長﨑 健

    遺伝子・デリバリー研究会第21回シンポジウム、第20回夏期セミナー  2022.08  遺伝子・デリバリー研究会

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    Venue:東京都  

  • 究極のダブルターゲッティングを目指したBNCTホウ素薬剤の開発 Invited Domestic conference

    長崎 健

    第1回 大阪公立大学 アカデミア創薬 ミニシンポジウム  2022.06 

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    Venue:大阪市  

  • 軟組織表面で自発的に被膜化する癒着防止材の 開発 Domestic conference

    深澤 今日子、松井 直、長崎 健、山岡 哲二

    第71回高分子学会年次大会  2022.05  高分子学会

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    Venue:オンライン  

  • Development of self-healing concrete containing bacteria immobilized on multilayer alginate beads Domestic conference

    2022.01 

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  • Functional evaluation of bispecific antibody against BSH and EGFR Domestic conference

    Kohei Yoshikawa, Taro Tachibana, Takeshi Nakanishi, Takeshi Nagasaki

    2022.01 

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  • Preparation of lactose-presented cyclodextrin vesicles for asialoglycoprotein receptor targeting Domestic conference

    Nao Tateishi, Hideki Azuma, Takeshi Nagasaki

    2022.01 

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  • A novel injectable biomaterial enabling gelation upon contact with soft tissue surface Domestic conference

    Sunao Matsui, Takeshi Nagasaki Tetsuji Yamaoka

    2022.01 

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  • Basic evaluation of a cross-linked gelatin hemostat International conference

    Hironori Arima, Kido Hirotsugu,Takeshi Nagasaki, Kenji Ohata, Takeo Goto

    日米バイオマテリアル学会・ジョイントシンポジウム2021  2022.01 

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  • Behavior of New type cured gelatin hemostat On Surgical site temperature International conference

    Kido Hirotsugu, Hironori Arima, Takeshi Nagasaki, Kenji Ohata, Takeo Goto

    日米バイオマテリアル学会・ジョイントシンポジウム2021  2022.01 

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  • 心筋梗塞治療向けのソルビトール応答性注射用ハイドロゲルの開発(Development of sorbitol-responsive injectable hydrogel for treating myocardial infarction) Domestic conference

    Le Hue Thi, Fukazawa Kyoko, Matsui Sunao, Nagasaki Takeshi, Mahara Atsushi, Yamaoka Tetsuji

    日本バイオマテリアル学会大会予稿集  2021.11  日本バイオマテリアル学会

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  • ガレクチン-3及びアシアロ糖タンパクレセプターをターゲットとしたラクトース提示型シクロデキストリンベシクルの作製 Domestic conference

    立石奈央、東 秀紀、加藤 麗子、長崎 健

    第18回 ホスト-ゲスト・超分子化学シンポジウム  2021.06 

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  • コウジ酸アルドール付加体を用いた光延条件下における新規ホモカップリング反応 Domestic conference

    東 秀紀、森島 康仁、中畔 慶人、加藤 麗子、長崎 健

    日本化学会第101春季年会  2021.03 

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  • 食品添加物用多糖類によって水溶化されたポルフィリン類縁体を用いたTurn-on型光線力学治療薬の開発 Domestic conference

    日野 彰大、杉川 幸太、河﨑 陸、甲元 一也、鈴木 利雄、長崎 健、池田 篤志

    日本化学会第101春季年会  2021.03 

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  • Possibility Study of Polymer Matrix Using Low Molecular Reaction for Medical Materials International conference

    Hirotsugu Kido, Hironori Arima, Takeshi Nagasaki, Kenji Ohata

    WBC 2020 VIRTUAL 11TH WORLD BIOMATERIALS CONGRESS  2020.12 

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  • Development of new hemostat using collagen peptide Domestic conference

    Hironori Arima, Hirotsugu Kido, Takeo Goto, Takeshi Nagasaki, Kenji Ohata

    WBC 2020 VIRTUAL 11TH WORLD BIOMATERIALS CONGRESS  2020.12 

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  • ガドリニウム陽荷電複合体の中性子捕捉療法における腫瘍増殖抑制効果の検討 Domestic conference

    柳衛 佳輝, 柳衛 宏宣, 侯 鉉, 柳川 将志, 石川 達矢, ノブリアナ・デヴィ , 森下 保幸, 松川 岳久, 久保田 章乃, 鈴木 実, 増永 慎一郎, 桜井 良憲, 田中 浩基, 長崎 健, 高橋 浩之

    日本癌治療学会学術集会抄録集  2020.10  (一社)日本癌治療学会

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  • BNCT 用ホウ素薬剤送達ツールとしての二重特異性抗体の作製と機能評価 Domestic conference

    金井大成, 立花 太郎, 中西 猛, 長崎 健

    バイオメディカルフォーラム2020  2020.02 

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  • 4-((E)-3-Hydroxyprop-1-enyl)phenyl acetate(HPA)を用いたメラノーマ特異的な新規薬剤送達及び光線力学療法への応用 Domestic conference

    森田昂祐, 関田亮佑,西祐太郎,東秀紀,長崎健

    バイオメディカルフォーラム2020  2020.02 

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  • 蛍光標識コウジ酸を用いたメラノーマに対する薬剤送達及び可視化ツールの開発 Domestic conference

    森島康仁, 大藤拓哉, 東秀紀, 長﨑健

    バイオメディカルフォーラム2020  2020.02 

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  • ホウ素中性子捕捉療法用新規ホウ素薬剤送達ツールとしての二重特異性抗体の抗原認識能 Domestic conference

    金井大成, 立花 太郎, 中西 猛, 長崎 健

    京都大学複合原子力科学研究所第54回学術講演会  2020.02 

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  • ホウ素中性子捕捉療法(BNCT)におけるホウ素薬剤送達用二重特異性抗体の作製と機能評価 Domestic conference

    金井大成, 立花 太郎, 中西 猛, 長崎 健

    第41回日本バイオマテリアル学会  2019.11 

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  • グルコースを放出してゲル化するインジェクタブル癒着防止材 Domestic conference

    山岡 哲二, 迎田 拓也, 徐 于懿, 神戸 裕介, 長崎 健

    日本バイオマテリアル学会大会予稿集  2019.11  日本バイオマテリアル学会

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  • Cellular uptake mechanism of kojic acid modified o-carborane as a boron drug toward melanoma-targeting BNCT International conference

    Takeshi Nagasaki, Satoshi Dowaki , Riku Kawasaki , Koki Matsuura , Yoshihide Hattori, Yoshinori Sakurai, Shin-ichiro Masunaga, Mitsunori Kirihata

    10th Young Researchers BNCT Meeting  2019.09 

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  • ホウ素中性子捕捉療法(BNCT)におけるホウ素薬剤送達に用いる二重特異性抗体の作製 Domestic conference

    金井大成, 立花 太郎, 中西 猛, 長崎 健

    第13回バイオ関連化学シンポジウム  2019.09  日本化学会

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  • グルコース放出によりゲル化する組織接着性インジェクタブル癒着防止材 Domestic conference

    山岡哲二, 迎田拓也, 徐于懿, 長﨑 健

    第48回医用高分子シンポジウム  2019.07  高分子学会医用高分子研究会

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  • コウジ酸はがん幹細胞標的化に使えるか? Domestic conference

    長﨑 健, 堂脇聖史, 河崎陸

    第22回生命化学研究会  2019.06  フロンティア生命化学研究会

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    Venue:北見工業大  

  • メラノーマBNCT用ホウ素薬剤及び転移抑制剤としてのコウジ酸修飾カルボランの機能評価 Domestic conference

    堂脇聖史, 松浦昂紀, 河崎 陸, 服部能英, 櫻井良憲, 増永慎一郎, 切畑光統, 長﨑 健

    バイオメディカルフォーラム2019  2019.02 

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  • Foundation of Educational Research Center of Graduate School of Engineering, Osaka City University Invited Domestic conference

    2019.02 

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  • アルギン酸で固定化した微生物を用いた炭酸カルシウムの結晶化の制御 Domestic conference

    西川怜里, 五十嵐幸一, 長崎 健

    化学工学会中国四国支部・関西支部合同徳島大会  2018.12 

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  • コウジ酸修飾カルボラン-シクロデキストリン複合体のBNCTホウ素薬剤としての評価 Domestic conference

    堂脇 聖史, 松浦 昂紀, 河崎 陸, 服部 能英, 櫻井 良憲, 増永 慎一郎, 切畑 光統, 長崎 健

    第40回日本バイオマテリアル学会  2018.11  日本バイオマテリアル学会

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  • Functional evaluation of kojic acid modified carborane developed as a boron drug for melanoma BNCT International conference

    Satoshi DOWAKI, Koki MATSUURA, Riku KAWASAKI, Yoshihide HATTORI, Yoshinori SAKURAI, Shinichiro MASUNAGA, Mitsunori KIRIHATA, Takeshi NAGASAKI

    18th International Congress on Neutron Capture Therapy  2018.11 

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  • 医療に役立つ材料:ハイドロゲル Invited Domestic conference

    長﨑 健

    第76回オープンラボラトリー「医療をイノベーションする工学研究」医工産連携ハブ技術の展開  2018.10 

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  • アントラキノン修飾シクロデキストリン・1’-アセトキシチャビコールアセテート複合体からなる葉酸提示自己集積ベシクルの作製と細胞内移行性 Domestic conference

    東秀紀, 福田千紗, 小島明子,長﨑健

    第45回生体分子科学討論会  2018.06 

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  • メラノーマBNCT用ホウ素薬剤として開発したコウジ酸修飾カルボランの機能評価 Domestic conference

    堂脇聖史, 松浦昂紀, 河崎 陸, 服部能英, 櫻井良憲, 増永慎一郎, 切畑光統, 長﨑 健

    第34回日本DDS学会  2018.06 

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  • 微量グルコースを放出してゲル化する新規癒着防止材の開発 Domestic conference

    迎田拓也、徐于懿、長崎健、山岡哲二

    第17回日本再生医療学会総会  2018.03 

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    Venue:パシフィコ横浜  

  • Aureobasidium pullulans由来β-1,3-グルカンに対するモノクローナル抗体の作製 Domestic conference

    寺井 涼、立花太郎、長崎健

    「バイオインターフェース先端マテリアルの創生」第8回シンポジウム  2018.02 

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    Venue:あべのメディックス  

  • グルコース濃度低下によりゲル化するインジェクタブル癒着防止材の開発 Domestic conference

    迎田拓也、徐于懿、長崎健、山岡哲二

    「バイオインターフェース先端マテリアルの創生」第8回シンポジウム  2018.02 

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    Presentation type:Poster presentation  

    Venue:あべのメディックス  

  • アントラキノン修飾シクロデキストリンの葉酸レセプターを介した取り込みの向上 Domestic conference

    福田千紗、東秀紀、長崎健

    「バイオインターフェース先端マテリアルの創生」第8回シンポジウム  2018.02 

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    Presentation type:Poster presentation  

    Venue:あべのメディックス  

  • グルコース濃度の減少に応答するインジェクタブルハイドロゲルの物性 Domestic conference

    迎田拓也、徐于懿、長崎健、山岡哲二

    第26回ポリマー材料フォーラム  2017.11 

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    Presentation type:Poster presentation  

    Venue:大阪国際交流センター  

  • Suppression of Melanoma Metastasis by Kojic Acid Modified Carborane International conference

    Satoshi Dowaki、Koki Matsuura、Riku Kawasaki、Yoshihide Hattori、Yoshinori Sakurai、Hiroki Tanaka、Shin-ichiro Masunaga、Mitsunori kirihata、Takeshi Nagasaki

    9th Young Researchers' BNCT Meeting  2017.11 

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    Presentation type:Poster presentation  

    Venue:京大おうばくプラザ  

  • 蛍光標識コウジ酸を用いたコウジ酸のメラノーマ選択的な取り込みに関する研究 Domestic conference

    森島康仁、大藤拓哉、東 秀紀、長崎 健

    第47回複素環化学討論会  2017.10 

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    Presentation type:Poster presentation  

    Venue:高知県立文化ホール  

  • Physical properties and effect of glucose concentration responsive injectable hydrogel International conference

    Takuya Mukaeda、Yu-I Hsu、Takeshi Nagasaki、 Tetsuji Yamaoka

    6th Asian Biomaterials Congress  2017.10 

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    Presentation type:Poster presentation  

    Venue:Appolo DIMORA, Thiruvananthapuram, India  

  • 次世代がん治療法BNCTのための薬物送達システム Invited Domestic conference

    長崎 健

    2nd Symposium on New Trends of Nano- and Bio- Materials Design in Supramolecular Chemistry  2017.10 

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    Presentation type:Oral presentation (invited, special)  

    Venue:志賀島国民休暇村  

  • メラノーマBNCT用ホウ素薬剤として開発したコウジ酸修飾カルボランのメラノーマ転移抑制効果に関する研究 Domestic conference

    堂脇聖史、河崎 陸、服部能英、櫻井良憲、増永慎一郎、切畑光統、長﨑 健

    第14回日本中性子捕捉療法学会学術大会  2017.09 

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    Presentation type:Poster presentation  

    Venue:郡山ビューホテルアネック  

  • インジェクタブルゲル型癒着防止材の設計と調整 Domestic conference

    迎田拓也、徐于懿、長崎健、山岡哲二

    第46回医用高分子シンポジウム  2017.07 

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    Presentation type:Poster presentation  

    Venue:産業技術総合研究所臨海副都心センター  

  • 水溶性βグルカンの精製とその性質 Domestic conference

    迎田拓也、徐于懿、長崎健、山岡哲二

    第63回高分子研究発表会[神戸]   2017.07 

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    Presentation type:Poster presentation  

    Venue:兵庫県民会館  

  • アントラキノン修飾シクロデキストリンへの葉酸レセプターをターゲットにした細胞選択性の付与 Domestic conference

    福田千紗、東秀紀、長崎健

    第33回日本DDS学会  2017.07 

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    Presentation type:Poster presentation  

    Venue:京都市勧業館みやこめっせ  

  • ダブルターゲティング〜分子機械の概念を利用した薬物送達システム〜 Invited Domestic conference

    長崎 健

    奈良女子大学大学院無機機能化学特論講演会  2017.06 

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    Presentation type:Oral presentation (invited, special)  

    Venue:奈良女子大心理学部会議室  

  • アントラキノン修飾シクロデキストリン/1’-アセトキシチャビコールアセテート複合体を用いた自己集積性ベシクルの作製と葉酸の提示 Domestic conference

    福田千紗、東秀紀、長崎健

    第15回 ホスト-ゲスト・超分子化学シンポジウム  2017.06 

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    Presentation type:Poster presentation  

    Venue:立命館大草津キャンパス  

  • リパーゼを用いたシコニン/アルカンニンの光学分割 Domestic conference

    東秀紀、榎本喬介、鈴木利雄、谷口泰造、長崎健

    第15回 ホスト-ゲスト・超分子化学シンポジウム  2017.06 

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    Presentation type:Poster presentation  

    Venue:立命館大草津キャンパス  

  • フタロシアニン亜鉛/β-1,3-グルカン複合体のdectin-1発現細胞選択的光線力学効果 Domestic conference

    萩原 麻未, 長崎 健, 鈴木 利雄

    日本バイオマテリアル学会大会予稿集  2015.11  日本バイオマテリアル学会

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    Presentation type:Oral presentation (general)  

  • チャビコール誘導体の光線力学療法への増強効果 Domestic conference

    小西 貴弘, 長崎 健, 東 秀紀, 小島 明子

    日本バイオマテリアル学会大会予稿集  2015.11  日本バイオマテリアル学会

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    Presentation type:Oral presentation (general)  

  • S-Allyl-glutathione類縁体によるマクロファージ活性化抑制 Domestic conference

    仲谷 友佑, 長崎 健, 東 秀紀, 高山 諒, 竹村 茂一, 南山 幸子

    日本バイオマテリアル学会大会予稿集  2015.11  日本バイオマテリアル学会

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    Presentation type:Oral presentation (general)  

  • β-1,3-グルカンを用いたシコニンの水溶化とdectin-1依存的細胞傷害性 Domestic conference

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    第17回生命化学研究会  2015.01 

  • 無水型フィトスフィンゴシンJaspine B 類縁体は腫瘍増殖を抑制する Domestic conference

    -

    第17回生命化学研究会  2015.01 

  • BNCTにおいて生体適合性高分子型薬剤は腫瘍集積性が向上する Domestic conference

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    第17回生命化学研究会  2015.01 

  • Melanoma-targeting boron delivery system using kojic acid-carborane conjugate International conference

    2nd International Workshop on BNCT  2014.12 

  • Development of Efficient Boron Delivery System Using Enhanced Permeability and Retention Effect in Boron Neutron Capture Therapy International conference

    The 2nd International Symposium on Fusion Materials  2014.11 

  • Cyclodextrin Complex of Kojic Acid Modified o-Carborane as a Novel BNCT Drug for Melanoma International conference

    The 2nd International Symposium on Fusion Materials  2014.11 

  • 生体適合性ポリリジンのホウ素クラスター修飾によるBNCT薬剤への応用 Domestic conference

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    第23回ポリマー材料フォーラム  2014.11 

  • コウジ酸修飾カルボランのメラノーマBNCT薬剤としての評価 Domestic conference

    -

    平成26年京都大学原子炉実験所専門研究会 研究炉及び加速器中性子源を用いた中性子捕捉療法の高度化に関する研究会  2014.09 

  • フタロシアニン亜鉛/aquaβ複合体のdectin-1依存的光線力学効果 Domestic conference

    -

    第2回バイオ関連化学シンポジウム若手フォーラム  2014.09 

  • ホウ素クラスター修飾ポリリジンを用いたBNCT用新規高分子型ホウ素薬剤の開発 Domestic conference

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    第8回バイオ関連化学シンポジウム  2014.09 

  • フタロシアニン亜鉛/β-1,3-グルカン複合体を用いた細胞選択的光線力学療法剤としての評価 Domestic conference

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    第8回バイオ関連化学シンポジウム  2014.09 

  • イットリウムオルトボレート/シクロデキストリン融合BNCT薬剤の腫瘍増殖抑制効果 Domestic conference

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    第63回高分子討論会  2014.09 

  • フタロシアニン亜鉛/β-1,3-グルカン複合体の光線力学療法剤としての評価 Domestic conference

    -

    第30回日本DDS学会  2014.07 

  • フタロシアニン亜鉛/β-1,3-グルカン複合体の光線力学療法剤としての評価 Domestic conference

    萩原 麻未, 長崎 健, 鈴木 利雄

    日本DDS学会学術集会プログラム予稿集  2014.07  日本DDS学会

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    Presentation type:Oral presentation (general)  

  • BSH修飾生体適合性ポリリジンの新規高分子型ホウ素中性子捕捉療法用薬剤としての評価 Domestic conference

    -

    第11回日本中性子捕捉療法学会学術大会  2014.07 

  • ホウ素クラスター修飾生分解性ポリリジンのBNCT薬剤としての評価 Domestic conference

    -

    第60回高分子研究発表会(神戸)  2014.07 

  • Kojic Acid Modified o-Carborane/Hydroxypropyl-β-Cyclodextrin Complex as Novel BNCT Drug for Melanoma International conference

    16th International Congress on Neutron Capture Therapy  2014.06 

  • Boron-containing Rare Earth Oxides Nanoparticles for Boron Neutron Capture Therapy International conference

    MRS2014Spring  2014.04 

  • 1’-Acetoxychavicol acetate(ACA)代謝産物のミトコンドリア経由アポトーシスに対する促進効果 Domestic conference

    -

    日本化学会第94春季年会  2014.03 

  • Stimuli-responsive drug delivery system: photoresponsive gene delivery system for gene therapy and boron delivery system for neutron capture therapy Domestic conference

    7th KIFEE International Symposium on Environment, Energy and Materials  2014.03 

  • メラノーマ選択性ホウ素クラスター修飾コウジ酸の新規BNCT用薬剤としての評価 Domestic conference

    -

    日本化学会第94春季年会  2014.03 

  • BNCT用含ホウ素希土類金属酸化物合成における粒径制御因子 Domestic conference

    -

    日本化学会第94春季年会  2014.03 

  • メフタロシアニン亜鉛/β-1,3-グルカン複合体を用いた細胞選択的光線力学効果 Domestic conference

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    日本化学会第94春季年会  2014.03 

  • コウジ酸修飾カルボランでメラノーマ選択的ホウ素中性子捕捉療法を実現する Domestic conference

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    第16回生命化学研究会  2014.01 

  • コウジ酸をリガンドとするメラノーマBNCT薬剤の開発に向けた基礎的検討 Domestic conference

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    平成25年度京都大学原子炉実験所専門研究会 研究炉及び加速器中性子源を用いた中性子捕捉療法の高度化に関する研究会  2013.12 

  • Carborane-Kojic Acid Conjugate for Melanoma-Targeting Boron Neutron Capture Therapy International conference

    2013Material Research Society Fall Meeting & Exposition  2013.12 

  • Melanoma-targeted boron delivery by kojic acid-appended carborane/cyclodextrin complexes for BNCT of malignant melanoma International conference

    6th Trilateral BNCT meeting between Taiwan and Japan  2013.12 

  • 新規がん治療のためのホウ素含有蛍光ナノ融合マテリアル Domestic conference

    -

    日本セラミック協会第26回秋季シンポジウム  2013.09 

  • Origin of double targeting concept is molecular machinery: photoresponsive gene carrier and boron carrier for BNCT Domestic conference

    New Trends of Nano- or Bio-materials Design in Supramolecular 2013  2013.09 

  • コウジ酸修飾カルボラン/2-ヒドロキシプロピル-β-シクロデキストリン複合体のメラノーマホウ素中性子捕捉療法薬剤としての評価 Domestic conference

    -

    第30回シクロデキストリンシンポジウム  2013.09 

  • Anti-tumor effect of kojic acid appended o-carborane as a novel boron agent for BNCT Domestic conference

    The 5th Asian Arden Conference  2013.08 

  • Kojic Acid-Appended Carborane/Hydroxypropyl-β-Cyclodextrin Complex: Melanoma-Selective Drug for Boron Neutron Capture Therapy International conference

    The 40th Annual Meeting & Exposition of the Controlled Release Society  2013.07 

  • マウスLPS刺激に対する抗炎症剤/β-1,3-グルカン複合体の血中サイトカイン濃度への影響 Domestic conference

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    第29回日本DDS学会  2013.07 

  • メラノーマに対するホウ素中性子捕捉療法用薬剤としてのコウジ酸修飾カルボラン Domestic conference

    -

    第29回日本DDS学会  2013.07 

  • Estimation of Boron-containing Rare Earth Oxides as Drugs for Boron Neutron Capture Therapy International conference

    The 40th Annual Meeting & Exposition of the Controlled Release Society  2013.07 

  • ミトコンドリア経由アポトーシスを制御する新規化合物の探索及び水溶化の検討 Domestic conference

    勝 玲子, 伊藤 奎亮, 安田 有沙, 東 秀紀, 長崎 健

    日本DDS学会学術集会プログラム予稿集  2013.06  日本DDS学会

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  • マウスLPS刺激に対する抗炎症剤/β-1,3-グルカン複合体の血中サイトカイン濃度への影響 Domestic conference

    李 家い, 平本 恵一, 笠原 恵美子, 東 秀紀, 長崎 健

    日本DDS学会学術集会プログラム予稿集  2013.06  日本DDS学会

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  • ホウ素クラスター修飾架橋ε-ポリリジンの高分子型ホウ素中性子捕捉療法薬剤への利用 Domestic conference

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    第62回高分子学会  2013.05 

  • コウジ酸修飾カルボラン/シクロデキストリン包接錯体のBNCT用新規キャリアとしての評価 Domestic conference

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    第10回ホスト・ゲスト化学シンポジウム  2013.05 

  • メラノーマ選択性コウジ酸修飾カルボランのホウ素中性子捕捉療法用新規キャリアとしての評価 Domestic conference

    長崎 健, 河崎 陸, 櫻井 良憲, 田中 浩基, 増永 慎一郎, 小野 公二, 切畑 光統

    日本バイオマテリアル学会大会予稿集  2012.11  日本バイオマテリアル学会

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  • 1'-Acetoxychavicol acetate/β-1,3-グルカン複合体の接触皮膚炎に対する抗炎症効果 Domestic conference

    李 家い, 東 秀紀, 平本 恵一, 笠原 恵美子, 長崎 健

    日本バイオマテリアル学会大会予稿集  2012.11  日本バイオマテリアル学会

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  • コウジ酸修飾o-カルボランのホウ素中性子捕捉療法用薬剤としての評価 Domestic conference

    河崎 陸, 櫻井 良憲, 田中 浩基, 増永 慎一郎, 小野 公二, 切畑 光統, 長崎 健

    日本DDS学会学術集会プログラム予稿集  2012.06  日本DDS学会

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  • β-1,3-グルカンを用いた関節リウマチに対する新規デリバリーシステム Domestic conference

    鹿子嶋 祐太, 李 家い, 東 秀紀, 池田 篤志, 長崎 健

    日本DDS学会学術集会プログラム予稿集  2012.06  日本DDS学会

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  • o-カルボランおよびチオドデカボランを導入したホウ素化コウジ酸の開発 Domestic conference

    -

    研究炉及び加速器中性子源を用いた中性子捕捉療法の高度化に関する研究会  2012.02 

  • 国際シンポジウム活動 Domestic conference

    -

    -  2012.01 

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    第5回アジア アーデン カンファレンス組織委員会 組織委員

  • Potential of polyion complex nanoparticle composed of mercaptoundecahydrododecaborane-appnded high molecular weight polyamine as a boron carrier for neutron capture therapy International conference

    2011 MRS Fall Meeting  2011.12 

  • Preparation and apoptogenic potency of Mcl-1 siRNA-encapsulated liposome containing short-chain 3-ketoceramide Domestic conference

    38th Inter. Sympo. Nucleic Acid Chemistry  2011.10 

  • 1’-Acetoxychavicol acetate/β-1,3-グルカンの接触皮膚炎に対する抗炎症効果 Domestic conference

    -

    第1回融合マテリアル若手スクール  2011.09 

  • Mcl-1 siRNA を包埋したケトセラミドリポソームの作製及びアポトーシス誘導活性評価 Domestic conference

    -

    アンチセンス・遺伝子・デリバリー シンポジウム 2011  2011.09 

  • α‐ガラクトシルセラミド類含有リポソームの作製およびその免疫増強作用の評価 Domestic conference

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    第5回バイオ関連化学シンポジウム  2011.09 

  • Dectin-1 選択的β-1,3-グルカン/C70複合体を用いたリウマチ光線力学療法に関する検討 Domestic conference

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    第5回バイオ関連化学シンポジウム  2011.09 

  • ホウ素クラスター融合ポリアミンを含むナノ粒子の腫瘍集積性と中性子捕捉反応による腫瘍増殖抑制効果 Domestic conference

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    第60回高分子討論会  2011.09 

  • Dectin-1 選択的β-1,3-グルカンを用いるリウマチ光線力学療法用デリバリーシステムの開発 Domestic conference

    -

    遺伝子・デリバリー研究会第11回夏期セミナー  2011.08 

  • 抗体作製におけるα-ガラクトシルセラミド類含有リポソームのアジュバント効果 Domestic conference

    -

    遺伝子・デリバリー研究会第11回夏期セミナー  2011.08 

  • 関節リウマチへの適応を目指した免疫細胞選択的PDT薬剤デリバリーシステムの開発 Domestic conference

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    第21回日本光線力学学会  2011.07 

  • ホウ素クラスター修飾ポリアミンナノ粒子の中性子捕捉療法薬剤としての評価 Domestic conference

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    第27回日本DDS学会  2011.06 

  • β-1,3-グルカン/C70複合体の光線力学効果における1’-Acetoxychavicol acetateの併用効果 Domestic conference

    -

    第27回日本DDS学会  2011.06 

  • シクロデキストリンを用いた水溶性1’-Acetoxychavicol Acetate 複合体の作製及び抗腫瘍効果に関する研究 Domestic conference

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    第7回ホスト・ゲスト化学シンポジウム  2011.05 

  • 短鎖ケトセラミドを含むMcl-1 siRNA封入リポソームの作製及びアポトーシス誘導活性評価 Domestic conference

    東 秀紀, 伊豆井 航, 長崎 健

    Drug Delivery System  2010.05  日本DDS学会

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  • シクロデキストリン-ACA包接錯体の作製及びその生理活性評価 Domestic conference

    相澤 結, 東 秀紀, 小島 明子, 長崎 健

    Drug Delivery System  2010.05  日本DDS学会

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    Presentation type:Oral presentation (general)  

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Industrial Property Rights

  • ゲル化組成物およびゲル構造体

    長崎 健, 鈴木利雄,山岡哲二,徐于懿

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    property_type:Patent 

    Application no:特願2017-137396 

    Patent/Registration no:6954529 

  • ホウ素中性子捕捉療法用組成物およびその製造方法

    長﨑 健・冨田恒之

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    property_type:Patent 

    Patent/Registration no:6083738 

    がん治療法の一つであるホウ素中性子捕捉療法に用いる発光性含ホウ素希土類酸化物組成物を発明した。

  • カルボラン修飾コウジ酸/シクロデキストリン包接錯体およびその製造方法

    上原幸樹、切畑光統、長崎 健

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    property_type:Patent 

    Patent/Registration no:5816896 

    ホウ素中性子捕捉療法に使用されるカルボランを、生体内へ導入しやすくするために水溶性かつ細胞親和性のある複合体に包接する技術に関する。

  • シトクロムc捕捉型アポトーシス抑制剤

    長崎 健・東 秀紀・築部 浩・篠田哲史

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    property_type:Patent 

    Patent/Registration no:4767295 

    アポトーシス時にミトコンドリアから漏出するシトクロムcを捕捉し、アポトーシスを抑制するアポトーシス抑制剤であって、下記の式で表される化合物またはその薬理学的に許容される塩を有効成分とすることを特徴とするアポトーシス抑制剤。

  • β-1,3-グルカン由来ポリアルデヒド/ポリアミンハイドロゲル

    長﨑 健、林 達郎、鈴木利雄、古川喜朗、大畑建治、石橋謙一

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    property_type:Patent 

    Patent/Registration no:5660781 

    ポリアミンには食品添加物や医薬外部品として承認済みで安全性に優れたε-PLL(ポリ-L-リジン)を基体とし高分子量化を行った。一方、菌類や酵母など微生物由来で側鎖グルコースを持つβ-1,3-グルカン(医薬品やサプリメントとしてこちらも安全性が確認されている)の側鎖グルコースに選択的にアルデヒドを導入したポリアルデヒドを調製し、両者からなる生体適合性が高く安全性・接着速度・強度に優れたハイドロゲル形成に成功した。

  • β-1,3-グルカン/カルボラン複合体

    新海征治・為末真吾・広瀬良治・櫻井和朗・長崎 健・沼田宗典

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    property_type:Patent 

    Patent/Registration no:5159125 

    ホウ素中性子捕捉療法に使用されるカルボランを生体内へ導入しやすくするための、水溶性かつ細胞親和性のある複合体及びその調製方法の提供。

  • 核酸構造体

    新海征治、長﨑 健、川津 猛、柿本真司

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    property_type:Patent 

    Patent/Registration no:5561893 

    細胞外から細胞核内に到る核酸の輸送を促進するタンパクまたはペプチドの少なくとも1種類、細胞内在性還元物質または光に応答して低分子化し得るカチオン性ポリマー、および、細胞内に導入されるべき遺伝子を含む核酸物質から構成されることを特徴とする核酸構造体。

  • 核酸複合体及びそれを用いる細胞内への核酸導入方法

    長崎健・新海征治・宇野篤・西田守

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    property_type:Patent 

    Patent/Registration no:4989039 

    細胞内への核酸導入効率が高く、かつ細胞毒性が低い上に、簡便、安価に調製が可能な核酸複合体、及びそれを用いた安全でかつトランスフェクション効率の高い細胞内への核酸導入方法を提供する。

  • 核内移行性核酸構造体

    新海征治・長崎 健・川津 猛・立花太郎

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    property_type:Patent 

    Patent/Registration no:4034274 

    細胞に遺伝子を導入するに際して核内移行を促進して効率的なトランスフェクションが確保できる新しい手法を提供する

  • 6-アミノ-6-デオキシキトサン,その製造方法およびそれより成る核酸導入剤

    新海征治・坂入信夫・長崎 健・佐藤 琢

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    property_type:Patent 

    Patent/Registration no:P4518804 

    キトサンのβ-(1-4)-2-アミノ-2-デオキシ-D-グルカン構造が6-デオキシ-6-アミノ構造で置換された新規なキトサン誘導体、該キトサン誘導体の製造方法、該キトサン誘導体を用いる細胞への核酸導入剤としての用途に関するもの

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Collaborative research (seeds) keywords

  • Boron Neutron Capture Therapy

    Category:Life Science 

Outline of collaborative research (seeds)

  • Development of cell culture devise

    随時

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    Request for collaborative research:The private sector, such as other institutions

    Type of research exchange:Technical consultation, Contract research, Joint research, Lecture

  • Controlled drug delivery by using functional protein

    随時

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    Request for collaborative research:The private sector, such as other institutions

    Type of research exchange:Technical consultation, Contract research, Joint research, Lecture

  • Development of biopolymer-based gene carrier

    随時

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    Request for collaborative research:The private sector, such as other institutions

    Type of research exchange:Technical consultation, Contract research, Joint research, Lecture

Grant-in-Aid for Scientific Research

  • 二重特異性抗体を用いたBNCTホウ素デリバリーシステムの開発

    Grant-in-Aid for Scientific Research(B)  2019.04

  • 超分子形成を応用した高機能性BNCT薬剤の開発

    Grant-in-Aid for Scientific Research(C)  2014.04

  • 含ホウ素希土類酸化物ナノ粒子のBNCT薬剤への応用

    新学術領域研究(研究領域提案型)  2013.04

  • Development of Inorganic Boron Cluster-fused Delivery Materials for the Neutron Capture Therapy

    2011.04

  • 細胞内動態制御による硼素中性子捕捉効果増強に関する研究

    Grant-in-Aid for Scientific Research(C)  2011.04

  • 脳神経外科手術用止血剤の開発に向けた組織接着性ハイドロゲルの安全性評価研究

    Grant-in-Aid for Scientific Research(C)  2011.04

  • Development of multifunctional vectors

    Grant-in-Aid for Scientific Research(C)  2005.04

  • 核移行シグナル化学修飾遺伝子による非ウイルスベクターの高効率化

    Grant-in-Aid for Scientific Research on Priority Areas  2002.04

  • Study on interaction between the photoresponsive dendrimer and biorelative compounds

    Grant-in-Aid for Scientific Research(C)  1997.04

  • 光応答性デンドリマ-の合成と機能

    奨励研究(A)  1996.04

  • 高機能性糖センシング化合物の開発

    奨励研究(A)  1994.04

  • 形状記憶と複製過程を利用した環状化合物の新規合成法

    奨励研究(A)  1993.04

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Contract research

  • メラノーマ中性子捕捉療法用コウジ酸修飾ホウ素薬剤の開発

    2011.08

Outline of education staff

  • 生体現象を分子レベルで解析し、人工的再構築を行うために必要な基盤知識の修得

Charge of on-campus class subject

  • 化学バイオ工学概論

    2021     Undergraduate

  • 特別演習

    2021     Graduate school

  • 有機化学2

    2021     Undergraduate

  • バイオ工学実験Ⅰ・Ⅱ

    2021     Undergraduate

  • 高分子化学Ⅱ

    2021     Undergraduate

  • 化学バイオ工学論

    2021     Undergraduate

  • 超分子化学特論

    2021     Graduate school

  • 化学バイオ工学論

    2020     Undergraduate

  • バイオ工学実験Ⅰ・Ⅱ

    2020     Undergraduate

  • 高分子化学Ⅱ

    2020     Undergraduate

  • 有機化学2

    2020     Undergraduate

  • 特別演習

    2020     Graduate school

  • 化学バイオ工学概論

    2020     Undergraduate

  • 超分子化学特論

    2020     Graduate school

  • バイオ工学実験Ⅰ・Ⅱ

    2019     Undergraduate

  • 高分子化学Ⅱ

    2019     Undergraduate

  • 有機化学2

    2019     Undergraduate

  • 特別演習

    2019     Graduate school

  • 化学バイオ工学概論

    2019     Undergraduate

  • 超分子化学特論

    2019     Graduate school

  • 化学バイオ工学論

    2019     Undergraduate

  • 超分子化学特論

    2018     Graduate school

  • 化学バイオ工学概論

    2018     Undergraduate

  • 特別演習

    2018     Graduate school

  • 有機化学2

    2018     Undergraduate

  • 高分子化学Ⅱ

    2018     Undergraduate

  • バイオ工学実験Ⅰ・Ⅱ

    2018     Undergraduate

  • 化学バイオ工学論

    2018     Undergraduate

  • 化学バイオ工学概論

    2017     Undergraduate

  • 特別演習

    2017     Graduate school

  • 高分子化学Ⅱ

    2017     Undergraduate

  • 有機化学2

    2017     Undergraduate

  • バイオ工学実験Ⅰ・Ⅱ

    2017     Undergraduate

  • 化学バイオ工学論

    2017     Undergraduate

  • 超分子化学特論

    2017     Graduate school

  • 特別演習

    2016     Graduate school

  • 高分子化学Ⅱ

    2016     Undergraduate

  • 有機化学2

    2016     Undergraduate

  • バイオ工学実験Ⅰ・Ⅱ

    2016     Undergraduate

  • 化学バイオ工学論

    2016     Undergraduate

  • 超分子化学特論

    2016     Graduate school

  • 超分子化学特論

    2015     Graduate school

  • 特別演習

    2015     Graduate school

  • 高分子化学Ⅱ

    2015     Undergraduate

  • 有機化学2

    2015     Undergraduate

  • バイオ工学実験Ⅰ・Ⅱ

    2015     Undergraduate

  • 化学バイオ工学論

    2015     Undergraduate

  • 超分子化学特論

    2014    

  • 化学バイオ工学論

    2014     Undergraduate

  • バイオ工学実験Ⅰ・Ⅱ

    2014     Undergraduate

  • 有機化学2

    2014     Undergraduate

  • 特別演習

    2014     Undergraduate

  • 超分子化学特論

    2013    

  • 技術者倫理

    2013     Undergraduate

  • 化学バイオ工学論

    2013     Undergraduate

  • バイオ工学実験Ⅰ・Ⅱ

    2013     Undergraduate

  • 有機化学2

    2013     Undergraduate

  • 特別演習

    2013     Undergraduate

  • 超分子化学特論

    2012    

  • バイオ工学実験Ⅰ・Ⅱ

    2012     Undergraduate

  • 化学バイオ工学論

    2012     Undergraduate

  • 有機化学2

    2012     Undergraduate

  • 特別演習

    2012    

  • 超分子化学特論

    2011    

  • 化学バイオ工学論

    2011     Undergraduate

  • 有機化学2

    2011     Undergraduate

  • バイオ工学実験Ⅰ・Ⅱ

    2011     Undergraduate

  • 特別演習

    2011     Undergraduate

  • 技術と生命

    2007     Undergraduate

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Charge of off-campus class subject

  • 無機機能化学

    2017.06
    Institution:Nara Women's University

  • 蛋白質有機化学特論

    2015.07
    Institution:Osaka University

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    Level:Postgraduate 

Faculty development activities

  • FD活動への貢献  2022

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    工学部入学時・卒業時アンケート実施
    工学研究科前期博士課程入学時・修了時アンケート実施
    9月と11月のFD集会へ参加

  • FD活動への貢献  2021

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    工学部入学時・卒業時アンケート実施
    工学研究科前期博士課程入学時・修了時アンケート実施
    9月と12月のFD集会へ参加

  • FD活動への貢献  2020

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    工学部入学時・卒業時アンケート実施
    工学研究科前期博士課程入学時・修了時アンケート実施
    9月と12月のFD集会へ参加

  • FD活動への貢献  2010

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    工学部FD集会(2010.9.28)・障害学生懇談会(2011.1.26)に参加

Number of instructed thesis, researches

  • 2022

    Number of instructed the graduation thesis:Number of graduation thesis reviews:2

    [Number of instructed the Master's Program] (previous term):[Number of instructed the Master's Program] (letter term):1

    [Number of master's thesis reviews] (chief):[Number of master's thesis reviews] (vice-chief):7

    [Number of doctoral thesis reviews] (chief):

  • 2021

    Number of instructed the graduation thesis:Number of graduation thesis reviews:4

    [Number of instructed the Master's Program] (previous term):[Number of instructed the Master's Program] (letter term):1

    [Number of master's thesis reviews] (chief):[Number of master's thesis reviews] (vice-chief):4

    [Number of doctoral thesis reviews] (chief):[Number of doctoral thesis reviews] (vice-chief):0

  • 2020

    Number of instructed the graduation thesis:Number of graduation thesis reviews:6

    [Number of instructed the Master's Program] (previous term):[Number of instructed the Master's Program] (letter term):1

    [Number of master's thesis reviews] (chief):[Number of master's thesis reviews] (vice-chief):4

    [Number of doctoral thesis reviews] (chief):[Number of doctoral thesis reviews] (vice-chief):0

  • 2010

    Number of instructed the graduation thesis:Number of graduation thesis reviews:3

    [Number of instructed the Master's Program] (previous term):[Number of instructed the Master's Program] (letter term):2

    [Number of master's thesis reviews] (chief):[Number of master's thesis reviews] (vice-chief):4

    [Number of doctoral thesis reviews] (chief):[Number of doctoral thesis reviews] (vice-chief):0

Original item・Special report (Education Activity)

  • 2022

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    Original item:創薬科学副専攻WG委員

  • 2021

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    Original item:オフィスアワーによる学修支援

  • 2021

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    Original item:工学研究科医工・生命工学教育研究センターと医学研究科による「バイオデザインプログラム」の実施

  • 2020

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    Original item:博士課程教育リーディングプログラムステアリング委員・資格審査委員・運営委員・実務委員

  • 2020

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    Original item:オフィスアワーによる学修支援

  • 2018

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    Original item:工学研究科医工・生命工学教育研究センター研究員

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Social Activities

  • 産学官連携活動

    2010.04 - 2011.03

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    財団法人 大阪市都市型産業振興センター島屋ビジネス・インキュベータ 入所審査委員会委員長

  • その他活動

    2008.04 - 2009.03

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    第4回次世代医療システム産業化フォーラム2008にて「βー1,3?グルカンを原料とする新規止血剤の開発」について講演

  • マスメディア活動

    2005.04 - 2006.03

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    日経産業新聞、2006.1.27、11面、「カニ殻成分で遺伝子導入」記事掲載

  • 小中高生向け教育活動

    2004.04 - 2005.03

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    夢・化学-21 化学への招待-大阪市立大学一日体験化学実験教室- 2004年度(責任者)

Visiting Lectures ⇒ Link to the list of Visiting Lectures

  • 先端医療と材料化学

    Category:Modern system science (knowledge information system, environmental system, educational welfare, psychology), Commerce (management, public management), Economics, Law (law, politics, administration), Literature (literature, philosophy, history, art, human behavior, language, culture, society / gender), Science (mathematics, physics, chemistry, biology, geology, biochemistry), Engineering (machinery, electronics / physics, electrical / electronics, electrical information, chemical biotechnology, architecture, cities (civil engineering / environment), material chemistry, aerospace, marine systems, applied chemistry, chemistry, materials), Life sciences (food, nutrition science, living environment, human welfare), Agricultural science (applied biology, biofunctional chemistry, green space environmental science), Medicine (medical care, rehabilitation, health exercise science, physical fitness / training, sports practice science), Nursing (nursing, sex education), Veterinary

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    Audience:Schoolchildren, Junior high school students, High school students, College students, Graduate students, Teachers, Guardians, Researchers, General, Scientific organization, Company, Civic organization, Governmental agency, Media

    再生医療や遺伝子・細胞治療など未来の治療法として期待されている先端医療の実現には、使用される医薬品は勿論のこと医用材料が重要な役割を担っています。材料を創製するための学問である化学の重要性などをわかりやすくお伝えします。

Foreigner acceptance

  • 2017

    International Students :1

  • 2010

    foreigners accepted :1

    International Students :2

Job title

  • Manager within the university

    Dean  2018.04 - 2022.03

Other

  • Job Career

    2007.04

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    Osaka City University

  • Job Career

    1995.04

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    Osaka City University

  • Job Career

    1994.04

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    Osaka City University