Updated on 2024/03/28

写真a

 
KAWABE Kouichi
 
Organization
Graduate School of Literature and Human Sciences Department of Human Behavioral Sciences Professor
School of Literature and Human Sciences Department of Human Behavioral Sciences
Title
Professor
Affiliation
Institute of Literature and Human Sciences

Position

  • Graduate School of Literature and Human Sciences Department of Human Behavioral Sciences 

    Professor  2022.04 - Now

  • School of Literature and Human Sciences Department of Human Behavioral Sciences 

    Professor  2022.04 - Now

Degree

  • Ph.D. ( University of Tsukuba )

Research Areas

  • Humanities & Social Sciences / Experimental psychology  / Physiological Psychology

  • Life Science / Neuroscience-general  / Behavioral Neuroscience

  • Humanities & Social Sciences / Experimental psychology  / Pharmacological Psychology

Research Interests

  • ラット

  • 行動テスト

  • 統合失調症

  • 精神疾患動物モデル

  • 高次認知機能

  • 学習・記憶

Research subject summary

  • 動物を用いた行動実験によって、学習・記憶現象を中心とした行動・心的機能の生理的基盤となる脳内機構についての研究を行っている。また、精神疾患の動物モデルを作成し、動物モデルとしての妥当性の評価を行っている。

Research Career

  • 精神疾患モデル動物の行動評価

    Individual

    2006 - Now 

  • Brain mechanisms in learning and memory

    learning and memory, neurotransmitter, brain  Individual

    1991.04 

  • Brain and behavior

    behavior, neurotransmitter, brain  Individual

    1991.04 

Professional Memberships

  • THE JAPANESE PSYCHOLOGICAL ASSOCIATION

      Domestic

  • Japanese Society of Neuropsychopharmacology

      Domestic

  • 日本神経科学学会

      Domestic

  • Japanese Society for Animal Psychology

      Domestic

Committee Memberships (off-campus)

  • 評議員   日本神経精神薬理学会  

    2011.10 - Now 

Job Career (off-campus)

  • 科学技術振興事業団戦略的基礎研究研究員   -

    1998 - 2001

Education

  • University of Tsukuba   Doctor's Course   Accomplished credits for doctoral program

    - 1998

  • University of Tsukuba     Graduated/Completed

    - 1991

Papers

  • Effects of early postnatal MK-801 treatment on behavioral properties in rats: Differences according to treatment schedule Reviewed

    Kawabe Kouichi, Miyamoto Eri

    BEHAVIOURAL BRAIN RESEARCH   370   2019.09( ISSN:0166-4328

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.bbr.2019.111926

  • Effects of chronic forced-swim stress on behavioral properties in rats with neonatal repeated MK-801 treatment Reviewed

    Kawabe, K.

    Pharmacology, Biochemistry and Behavior   159   48 - 54   2017.08

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    Publishing type:Research paper (scientific journal)   Kind of work:Single Work  

  • 1'-Acetoxychavicol acetate ameliorates age-related spatial memory deterioration by increasing serum ketone body production as a complementary energy source for neuronal cells. Reviewed

    Kojima-Yuasa A, Yamamoto T, Yaku K, Hirota S, Takenaka S, Kawabe K, Matsui-Yuasa I

    Chemico-biological interactions   257   101 - 109   2016.09( ISSN:0009-2797

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.cbi.2016.07.031

    PubMed

  • Hippocampal AP5 treatment impairs both spatial working and reference memory in radial maze performance in rats. Reviewed

    Yamada K, Shimizu M, Kawabe K, Ichitani Y

    European journal of pharmacology   758   137 - 141   2015.07( ISSN:0014-2999

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.ejphar.2015.03.080

    PubMed

  • 新生仔期NMDA受容体拮抗薬反復投与動物の行動特性―統合失調症動物モデルとして―

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    人文研究   65   47 - 62   2014.03

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    Publishing type:Research paper (bulletin of university, research institution)   Kind of work:Single Work  

  • Behavioral properties in rats and mice with repeated neonatal treatment by NMDA antagonists : as an animal model for schizophrenia Reviewed

    Kawabe Kouichi

    Osaka City University, Studies in the humanities   65   47 - 62   2014( ISSN:0491-3329

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    Publishing type:Research paper (scientific journal)   Kind of work:Single Work  

    CiNii Article

  • Effects of neonatal repeated MK-801 treatment on delayed non-matching-to-position responses in rats.

    NeuroReport   19 ( 9 )   969 - 973   2008

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    Publishing type:Research paper (scientific journal)  

  • Repeated treatment with N-methyl-D-aspartate antagonists in neonatal, but not adult, rats causes long-term deficits of radial-arm maze learning.

    Brain Research   1169   77 - 86   2007

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    Publishing type:Research paper (scientific journal)  

  • 動物を用いた指示性忘却(Directed Forgetting)に関する研究の概観

    山田一夫,一谷幸男

    筑波大学心理学研究   33   1 - 7   2007

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    Publishing type:Research paper (bulletin of university, research institution)  

  • ラットの視覚的遅延見本合わせ学習

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    人文研究   55 ( 3 )   53 - 65   2004

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    Publishing type:Research paper (bulletin of university, research institution)   Kind of work:Single Work  

  • Fronto-parieto-cerebellar interaction associated with intermanual transfer of monkey tool-use learning.

    Neuroscience Letters   339 ( 2 )   123 - 126   2003

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    Publishing type:Research paper (scientific journal)  

  • Visualization of α5 subunit of GABAD2AD2 / benzodiazepine receptor by [D111D1C]Ro-4513 using positron emission tomography.

    Synapse   47 ( 3 )   200 - 208   2003

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    Publishing type:Research paper (scientific journal)  

  • Syntheses and pharmacological evaluation of two potent antagonists for dopamine DD24D2 receptors: [D111D1C]YM-50001 and N-[2-[4-(4-Chlorophenyl)-piperizin-1-yl]ethyl]-3-[D111D1C]methoxybenzamide.

    Nuclear Medicine& Biology   29 ( 2 )   233 - 241   2002

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    Publishing type:Research paper (scientific journal)  

  • Synthesis and evaluation of 3-(4-chlorobenzyl)-8-[D111D1C]methoxy-1,2,3,4-tetrahydrochromeno[3,4-c]pyridin-5-one: a PET tracer for imaging sigmaD21D2 receptors.

    Nuclear Medicine& Biology   29 ( 4 )   469 - 476   2002

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    Publishing type:Research paper (scientific journal)  

  • Clozapine can induce high dopamine DD22D2 receptor occupancy in vivo.

    Psychopharmacology   160 ( 1 )   107 - 112   2002

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    Publishing type:Research paper (scientific journal)  

  • A positron-emitter labeled glycineD2BD2 site antagonist, [D111D1C]L-703,717, preferentially binds to a cerebellar NMDA receptor subtype consisting of GluR ε3 subunit in vivo, but not in vitro.

    Synapse   43 ( 2 )   131 - 133   2002

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    Publishing type:Research paper (scientific journal)  

  • A prodrug of NMDA/glycine site antagonist, L-703,717, with improved BBB permeability: 4-acetoxy derivative and its positron-emitter labeled analog.

    Chemical& Pharmaceutical Bulletin   49 ( 2 )   147 - 150   2001

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    Publishing type:Research paper (scientific journal)  

  • In vivo binding properties of [carbonyl-D111D1C]WAY-100635: effect of endogenous serotonin.

    Synapse   40 ( 2 )   122 - 129   2001

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    Publishing type:Research paper (scientific journal)  

  • Effect of endogenous dopamine on extrastriatal [D111D1C]FLB 457 binding measured by PET.

    41 ( 2 )   87 - 95   2001

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    Publishing type:Research paper (scientific journal)  

  • A strategy for increasing the brain uptake of a radioligand in animals: use of a drug that inhibits plasma protein binding.

    Nuclear Medicine& Biology   27 ( 4 )   357 - 360   2001

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    Publishing type:Research paper (scientific journal)  

  • Functional brain mapping of monkey tool use.

    NeuroImage   14 ( 4 )   853 - 861   2001

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    Publishing type:Research paper (scientific journal)  

  • 海馬の長期増強の抑制・亢進に伴った学習・記憶能力の変化―McEachern& Shaw (1996)の可塑性-病理学的変性連続体モデルに関する一考察―

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    人文研究   53 ( 3 )   75 - 90   2001

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    Publishing type:Research paper (bulletin of university, research institution)   Kind of work:Single Work  

  • Extrastriatal dopamine D2 receptor density and affinity in the human brain measured by 3D PET.

    International Journal of Neuropsychopharmacology   2 ( 2 )   73 - 82   1999

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    Publishing type:Research paper (scientific journal)  

  • Effects of intrahippocampal AP5 treatment on the radial-arm maze performance in rats.

    Brain Research   781   300 - 306   1998

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    Publishing type:Research paper (scientific journal)  

  • Intrahippocampal D-cycloserine treatment improves MK-801-induced memory deficits in the radial-arm maze task.

    Brain Research   814   226 - 230   1998

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    Publishing type:Research paper (scientific journal)  

  • ラットの学習・記憶における脳内グルタミン酸のレセプターの役割に関する研究の動向

    岩崎庸男

    筑波大学心理学研究   17   19 - 27   1995

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    Publishing type:Research paper (bulletin of university, research institution)  

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Presentations

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Outline of collaborative research (seeds)

  • 生理心理学、行動神経科学、薬理心理学、行動薬理学

    2001-

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    Request for collaborative research:The private sector, such as other institutions

    Type of research exchange:Technical consultation, Contract research, Joint research

    Application fields / methods etc:脳・神経科学、薬理学などへの応用が期待される。

    動物(主にラット)を用いた行動実験により、学習・記憶を中心とした行動・心的機能の生理的基盤となる脳内機構を探求する。また、中枢神経系に作用する薬物の各種行動への影響を調べる。

Grant-in-Aid for Scientific Research

  • 統合失調症モデルラットにおける虚連合記憶―動物の「妄想」研究の基礎として

    Grant-in-Aid for Challenging Research (Pioneering)/(Exploratory)  2014.04

  • 統合失調症モデル動物である新生仔期NMDA拮抗薬投与ラットはストレスに対し脆弱か

    Grant-in-Aid for Scientific Research(C)  2011.04

  • 新生仔期NMDA拮抗薬投与ラットの行動異常の解析:統合失調症の動物モデルとして

    Grant-in-Aid for Scientific Research(C)  2008.04

Outline of education staff

  • 担当科目:(全学共通科目)心と脳、(学部)心理学実験演習I・III・IV。  「心と脳」では、脳研究においてこれまで得られている知見をとりあげ、脳や神経細胞の構造、神経系における情報伝達の仕組みや、脳と精神機能・行動との関係について概説する。  学部教育においては、実験心理学に関する知識の修得を目指すと同時に、動物を用いた行動実験を通じ、学習・記憶を中心とした高次精神機能・行動と脳の関係についての理解を深めることに主眼を置いている。

Charge of on-campus class subject

  • 動物心理学特論

    1900     Undergraduate

  • 生理心理学特論

    1900     Undergraduate

  • 心理学実験演習IIII・IV

    1900     Undergraduate

  • 心理学実験演習I・II

    1900     Undergraduate

  • 心理学への招待

    1900     Undergraduate

  • 心と脳

    1900     Undergraduate

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Number of instructed thesis, researches

  • 2023

    Number of instructed the graduation thesis:Number of graduation thesis reviews:10

    [Number of instructed the Master's Program] (previous term):[Number of instructed the Master's Program] (letter term):0

    [Number of master's thesis reviews] (chief):[Number of master's thesis reviews] (vice-chief):1

    [Number of doctoral thesis reviews] (chief):[Number of doctoral thesis reviews] (vice-chief):0

Visiting Lectures ⇒ Link to the list of Visiting Lectures

  • 精神疾患動物モデルの作製とその評価

    Category:Literature (literature, philosophy, history, art, human behavior, language, culture, society / gender)

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    Audience:High school students