Updated on 2024/04/03

写真a

 
MATSUBARA Tsutomu
 
Organization
Graduate School of Medicine Department of Basic Medical Science Associate Professor
School of Medicine Department of Medical Science
Title
Associate Professor
Affiliation
Institute of Medicine

Position

  • Graduate School of Medicine Department of Basic Medical Science 

    Associate Professor  2022.04 - Now

  • School of Medicine Department of Medical Science 

    Associate Professor  2022.04 - Now

Degree

  • 博士(薬学) ( Tohoku University )

Research Areas

  • Life Science / Pathological biochemistry

  • Life Science / Anatomy

  • Life Science / Metabolism and endocrinology

Papers

  • New Era of Immune-Based Therapy in Intrahepatic Cholangiocarcinoma. Reviewed

    Etsushi Kawamura, Tsutomu Matsubara, Norifumi Kawada

    Cancers   15 ( 15 )   2023.08( ISSN:2072-6694

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    Publishing type:Research paper (scientific journal)   International / domestic magazine:International journal  

    Intrahepatic cholangiocarcinoma (CC) accounts for approximately 20% of all biliary tract cancer (BTC) cases and 10-15% of all primary liver cancer cases. Many patients are diagnosed with unresectable BTC, and, even among patients with resectable BTC, the 5-year survival rate is approximately 20%. The BTC incidence rate is high in Southeast and East Asia and has increased worldwide in recent years. Since 2010, cytotoxic chemotherapy, particularly combination gemcitabine + cisplatin (ABC-02 trial), has been the first-line therapy for patients with BTC. In 2022, a multicenter, double-blind, randomized phase 3 trial (TOPAZ-1 trial) examined the addition of programmed death-ligand 1 immunotherapy (durvalumab) to combination gemcitabine + cisplatin for BTC treatment, resulting in significantly improved survival without notable additional toxicity. As a result of this trial, this three-drug combination has become the new standard first-line therapy, leading to notable advances in BTC management for the first time since 2010. The molecular profiling of BTC has continued to drive the development of new targeted therapies for use when first-line therapies fail. Typically, second-line therapy decisions are based on identified genomic alterations in tumor tissue. Mutations in fibroblast growth factor receptor 1/2/3, isocitrate dehydrogenase 1/2, and neurotrophic tyrosine receptor kinase A/B/C are relatively frequent in intrahepatic CC, and precision medicines are available that can target associated pathways. In this review, we suggest strategies for systemic pharmacotherapy with a focus on intrahepatic CC, in addition to presenting the results and safety outcomes of clinical trials evaluating immune checkpoint inhibitor therapies in BTC.

    DOI: 10.3390/cancers15153993

    PubMed

  • Hypo-osmolarity induces apoptosis resistance via TRPV2-mediated AKT-Bcl-2 pathway. Reviewed

    Hayato Urushima, Tsutomu Matsubara, Masaaki Miyakoshi, Shioko Kimura, Hideto Yuasa, Katsutoshi Yoshizato, Kazuo Ikeda

    American journal of physiology. Gastrointestinal and liver physiology   324 ( 3 )   G219 - G230   2023.03( ISSN:0193-1857

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    Publishing type:Research paper (scientific journal)   International / domestic magazine:International journal  

    In cirrhosis, several molecular alterations such as resistance to apoptosis could accelerate carcinogenesis. Recently, mechanotransduction has been attracting attention as one of the causes of these disturbances. In patients with cirrhosis, the serum sodium levels progressively decrease in the later stage of cirrhosis, and hyponatremia leads to serum hypo-osmolality. Since serum sodium levels in patients with cirrhosis with liver cancer are inversely related to cancer's number, size, stage, and cumulative survival, we hypothesized that hypo-osmolality-induced mechanotransduction under cirrhotic conditions might contribute to oncogenesis and/or progression of hepatocellular carcinoma (HCC). In this study, we adjusted osmosis of culture medium by changing the sodium chloride concentration and investigated the influence of hypotonic conditions on the apoptosis resistance of an HCC cell line, HepG2, using a serum-deprivation-induced apoptosis model. By culturing the cells in a serum-free medium, the levels of an antiapoptotic protein Bcl-2 were downregulated. In contrast, the hypotonic conditions caused apoptosis resistance by upregulation of Bcl-2. Next, we examined which pathway was involved in the apoptosis resistance. Hypotonic conditions enhanced AKT signaling, and constitutive activation of AKT in HepG2 cells led to upregulation of Bcl-2. Moreover, we revealed that the enhancement of AKT signaling was caused by intracellular calcium influx via a mechanosensor, TRPV2. Our findings suggested that hyponatremia-induced serum hypotonic in patients with cirrhosis promoted the progression of hepatocellular carcinoma.NEW & NOTEWORTHY Our study first revealed that hypo-osmolarity-induced mechanotransduction enhanced calcium-mediated AKT signaling via TRPV2 activation, resulting in contributing to apoptosis resistance. The finding indicates a possible view that liver cirrhosis-induced hyponatremia promotes hepatocellular carcinogenesis.

    DOI: 10.1152/ajpgi.00138.2022

    PubMed

  • Nitric oxide derived from cytoglobin-deficient hepatic stellate cells causes suppression of cytochrome c oxidase activity in hepatocytes. Reviewed

    Yoshinori Okina, Misako Sato-Matsubara, Yasutoshi Kido, Hayato Urushima, Atsuko Daikoku, Chiho Kadono, Yu Nakagama, Yuko Nitahara, Truong Huu Hoang, Le Thi Thanh Thuy, Tsutomu Matsubara, Naoko Ohtani, Kazuo Ikeda, Katsutoshi Yoshizato, Norifumi Kawada

    Antioxidants & redox signaling   38 ( 7-9 )   463 - 479   2023.03( ISSN:1523-0864

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    Publishing type:Research paper (scientific journal)   International / domestic magazine:International journal  

    AIMS: Cell-cell interactions between hepatocytes and other liver cells are key to maintaining liver homeostasis. Cytoglobin (CYGB), expressed exclusively by hepatic stellate cells (HSC), is essential in mitigating mitochondrial oxidative stress. CYGB absence causes hepatocyte (Hep) dysfunction and evokes hepatocarcinogenesis through an elusive mechanism. CYGB deficiency is speculated to hinder nitric oxide dioxygenase (NOD) activity, resulting in the elevated formation and release of NO. Hence, we hypothesized that NO accumulation induced by the loss of NOD activity in CYGB-deficient HSC could adversely affect mitochondrial function in Hep, leading to disease progression. RESULTS: NO, a membrane-permeable gas metabolite overproduced by CYGB-deficient HSC, diffuses into neighboring hepatocytes to reversibly inhibit cytochrome c oxidase (CcO), resulting in the suppression of respiratory function in an electron transport chain (ETC). The binding of NO to CcO is proved using purified CcO fractions from Cygb knockout (Cygb-/-) mouse liver mitochondria. It's inhibitory action towards CcO specific activity is fully reversed by the external administration of oxyhemoglobin chasing away the bound NO. Thus, these findings indicate that the attenuation of respiratory function in ETC causes liver damage through formation of excessive reactive oxygen species. Treating Cygb-/- mice with an NO synthase inhibitor successfully relieved NO-induced inhibition of CcO activity in vivo. INNOVATION AND CONCLUSION: Our findings provide a biochemical link between CYGB-absence in HSC and neighboring hepatocyte dysfunction; mechanistically the absence of CYGB in HSC causes mitochondrial dysfunction of Hep via the inhibition of CcO activity by HSC-derived NO.

    DOI: 10.1089/ars.2021.0279

    PubMed

  • Suppression of intrahepatic cholangiocarcinoma cell growth by SKI via upregulation of the CDK inhibitor p21. Reviewed

    Kawamura E, Matsubara T, Daikoku A, Deguchi S, Kinoshita M, Yuasa H, Urushima H, Odagiri N, Motoyama H, Kotani K, Kozuka R, Hagihara A, Fujii H, Uchida-Kobayashi S, Tanaka S, Takemura S, Iwaisako K, Enomoto M, Taguchi YH, Tamori A, Kubo S, Ikeda K, Kawada N

    FEBS open bio   12 ( 12 )   2122 - 2135   2022.12

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    DOI: 10.1002/2211-5463.13489

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  • Cancer cells produce liver metastasis via gap formation in sinusoidal endothelial cells through proinflammatory paracrine mechanisms Reviewed

    Truong Huu Hoang, Misako Sato-Matsubara, Hideto Yuasa, Tsutomu Matsubara, Le Thi Thanh Thuy, Hiroko Ikenaga, Dong Minh Phuong, Ngo Vinh Hanh, Vu Ngoc Hieu, Dinh Viet Hoang, Hoang Hai, Yoshinori Okina, Masaru Enomoto, Akihiro Tamori, Atsuko Daikoku, Hayato Urushima, Kazuo Ikeda, Ninh Quoc Dat, Yutaka Yasui, Hiroji Shinkawa, Shoji Kubo, Ryota Yamagishi, Naoko Ohtani, Katsutoshi Yoshizato, Jordi Gracia-Sancho, Norifumi Kawada

    Science Advances   8 ( 39 )   eabo5525   2022.09( eISSN:2375-2548

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    Intracellular gap (iGap) formation in liver sinusoidal endothelial cells (LSECs) is caused by the destruction of fenestrae and appears under pathological conditions; nevertheless, their role in metastasis of cancer cells to the liver remained unexplored. We elucidated that hepatotoxin-damaged and fibrotic livers gave rise to LSECs-iGap formation, which was positively correlated with increased numbers of metastatic liver foci after intrasplenic injection of Hepa1-6 cells. Hepa1-6 cells induced interleukin-23–dependent tumor necrosis factor–α (TNF-α) secretion by LSECs and triggered LSECs-iGap formation, toward which their processes protruded to transmigrate into the liver parenchyma. TNF-α triggered depolymerization of F-actin and induced matrix metalloproteinase 9 (MMP9), intracellular adhesion molecule 1, and CXCL expression in LSECs. Blocking MMP9 activity by doxycycline or an MMP2/9 inhibitor eliminated LSECs-iGap formation and attenuated liver metastasis of Hepa1-6 cells. Overall, this study revealed that cancer cells induced LSEC-iGap formation via proinflammatory paracrine mechanisms and proposed MMP9 as a favorable target for blocking cancer cell metastasis to the liver.

    DOI: 10.1126/sciadv.abo5525

    PubMed

  • Title: Cloaking the ACE2 receptor with salivary cationic proteins inhibits SARS-CoV-2 entry. Reviewed

    Katsutoshi Yoshizato, Toshio Taira, Misako Sato-Matsubara, Shizuko Sekiguchi, Yoriko Yabunaka, Yukimi Kira, Tetsu Ohashi, Atsuko Daikoku, Ken Ofusa, Chiho Kadono, Daisuke Oikawa, Tsutomu Matsubara, Yu Nakagama, Yasutoshi Kido, Fuminori Tokunaga, Kazuo Ikeda, Akira Kaneko, Norifumi Kawada

    Journal of biochemistry   172 ( 4 )   205 - 216   2022.09( ISSN:0021-924X

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    Publishing type:Research paper (scientific journal)   International / domestic magazine:International journal  

    Saliva contributes to the innate immune system, which suggests that it can prevent SARS-CoV-2 entry. We studied the ability of healthy salivary proteins to bind to angiotensin-converting enzyme 2 (ACE2) using biolayer interferometry and pull-down assays. Their effects on binding between the receptor-binding domain of the SARS-CoV-2 spike protein S1 (S1) and ACE2 were determined using an enzyme-linked immunosorbent assay. Saliva bound to ACE2 and disrupted the binding of S1 to ACE2 and four ACE2-binding salivary proteins were identified, including cationic histone H2A and neutrophil elastase, which inhibited the S1-ACE2 interaction. Calf thymus histone (ct-histone) also inhibited binding as effectively as histone H2A. The results of a cell-based infection assay indicated that ct-histone suppressed SARS-CoV-2 pseudoviral invasion into ACE2-expressing host cells. Manufactured polypeptides, such as ε-poly-L-lysine, also disrupted S1-ACE2 binding, indicating the importance of the cationic properties of salivary proteins in ACE2 binding. Overall, we demonstrated that positively-charged salivary proteins are a barrier against SARS-CoV-2 entry by cloaking the negatively-charged surface of ACE2, and provided a view that the cationic polypeptides represent a preventative and therapeutic treatment against COVID-19.

    DOI: 10.1093/jb/mvac054

    PubMed

  • Glass-patternable notch-shaped microwave architecture for on-chip spin detection in biological samples. Reviewed

    Keisuke Oshimi, Yushi Nishimura, Tsutomu Matsubara, Masuaki Tanaka, Eiji Shikoh, Li Zhao, Yajuan Zou, Naoki Komatsu, Yuta Ikado, Yuka Takezawa, Eriko Kage-Nakadai, Yumi Izutsu, Katsutoshi Yoshizato, Saho Morita, Masato Tokunaga, Hiroshi Yukawa, Yoshinobu Baba, Yoshio Teki, Masazumi Fujiwara

    Lab on a chip   22 ( 13 )   2519 - 2530   2022.06

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    Publishing type:Research paper (scientific journal)   International / domestic magazine:International journal  

    We report a notch-shaped coplanar microwave waveguide antenna on a glass plate designed for on-chip detection of optically detected magnetic resonance (ODMR) of fluorescent nanodiamonds (NDs). A lithographically patterned thin wire at the center of the notch area in the coplanar waveguide realizes a millimeter-scale ODMR detection area (1.5 × 2.0 mm2) and gigahertz-broadband characteristics with low reflection (∼8%). The ODMR signal intensity in the detection area is quantitatively predictable by numerical simulation. Using this chip device, we demonstrate a uniform ODMR signal intensity over the detection area for cells, tissue, and worms. The present demonstration of a chip-based microwave architecture will enable scalable chip integration of ODMR-based quantum sensing technology into various bioassay platforms.

    DOI: 10.1039/d2lc00112h

    PubMed

  • Activation of Hepatic Stellate Cells Requires Dissociation of E-Cadherin-Containing Adherens Junctions with Hepatocytes. Reviewed

    Urushima H, Yuasa H, Matsubara T, Kuroda N, Hara Y, Inoue K, Wake K, Sato T, Friedman SL, Ikeda K

    The American journal of pathology   191 ( 3 )   438 - 453   2021.03( ISSN:0002-9440

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    DOI: 10.1016/j.ajpath.2020.12.007

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  • Wide-field fluorescent nanodiamond spin measurements toward real-time large-area intracellular thermometry. Reviewed

    Nishimura Y, Oshimi K, Umehara Y, Kumon Y, Miyaji K, Yukawa H, Shikano Y, Matsubara T, Fujiwara M, Baba Y, Teki Y

    Scientific reports   11 ( 1 )   4248   2021.02

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41598-021-83285-y

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  • Stress can attenuate hepatic lipid accumulation via elevation of hepatic β-muricholic acid levels in mice with nonalcoholic steatohepatitis. Reviewed

    Takada S, Matsubara T, Fujii H, Sato-Matsubara M, Daikoku A, Odagiri N, Amano-Teranishi Y, Kawada N, Ikeda K

    Laboratory investigation; a journal of technical methods and pathology   101 ( 2 )   193 - 203   2021.02( ISSN:0023-6837

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41374-020-00509-x

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  • Lysosomal SLC46A3 modulates hepatic cytosolic copper homeostasis. Reviewed

    Kim JH, Matsubara T, Lee J, Fenollar-Ferrer C, Han K, Kim D, Jia S, Chang CJ, Yang H, Nagano T, Krausz KW, Yim SH, Gonzalez FJ

    Nature communications   12 ( 1 )   290   2021.01

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41467-020-20461-0

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  • Anti-fibrotic treatments for chronic liver diseases: the present and the future. Reviewed

    Odagiri N, Matsubara T, Sato-Matsubara M, Fujii H, Enomoto M, Kawada N

    Clinical and molecular hepatology   2020.12( ISSN:2287-2728

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    DOI: 10.3350/cmh.2020.0187

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  • TGF-β-driven reduction of cytoglobin leads to oxidative DNA damage in stellate cells during non-alcoholic steatohepatitis. Reviewed

    Okina Y, Sato-Matsubara M, Matsubara T, Daikoku A, Longato L, Rombouts K, Thanh Thuy LT, Ichikawa H, Minamiyama Y, Kadota M, Fujii H, Enomoto M, Ikeda K, Yoshizato K, Pinzani M, Kawada N

    Journal of hepatology   2020.04( ISSN:0168-8278

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.jhep.2020.03.051

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  • Adrenoceptor-related decrease in serum triglycerides is independent of PPARα activation. Reviewed

    Konstandi M, Kypreos KE, Matsubara T, Xepapadaki E, Shah YM, Krausz K, Andriopoulou CE, Kofinas A, Gonzalez FJ

    The FEBS journal   286 ( 21 )   4328 - 4341   2019.06( ISSN:1742-464X

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/febs.14966

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  • Adrenoceptor-stimulated inflammatory response in stress-induced serum amyloid A synthesis. Reviewed

    Konstandi M, Sotiropoulos I, Matsubara T, Malliou F, Katsogridaki A, Andriopoulou CE, Gonzalez FJ

    Psychopharmacology   2019.01( ISSN:0033-3158

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00213-018-5149-4

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  • Involvement of ERK1/2 activation in the gene expression of senescence-associated secretory factors in human hepatic stellate cells. Reviewed

    Odagiri N, Matsubara T, Higuchi M, Takada S, Urushima H, Sato-Matsubara M, Teranishi Y, Yoshizato K, Kawada N, Ikeda K

    Molecular and cellular biochemistry   2018.11( ISSN:0300-8177

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s11010-018-3466-x

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  • Promoter Activity of Human Cytoglobin Is Regulated By TGF beta 1-Smad2-SP3 Pathway in Human, but Not Mouse, Hepatic Stellate Cells Reviewed

    Okina Yoshinori, Matsubara Misako, Matsubara Tsutomu, Daikoku Atsuko, Fujii Hideki, Rombouts Krista, Okina Kazuo, Pinzani Massimo, Kawada Norifumi

    HEPATOLOGY   68   638A - 638A   2018.10( ISSN:0270-9139

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  • Fibroblast growth factor 2 (FGF2) regulates cytoglobin expression and activation of human hepatic stellate cells via JNK signaling Reviewed

    Sato-Matsubara Misako, Matsubara Tsutomu, Daikoku Atsuko, Okina Yoshinori, Longato Lisa, Rombouts Krista, Le Thi Thanh Thuy, Adachi Jun, Tomonaga Takeshi, Ikeda Kazuo, Yoshizato Katsutoshi, Pinzani Massimo, Kawada Norifumi

    JOURNAL OF BIOLOGICAL CHEMISTRY   292 ( 46 )   18961 - 18972   2017.11( ISSN:0021-9258

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1074/jbc.M117.793794

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  • Lack of epithelial PPARγ causes cystic adenomatoid malformations in mouse fetal lung. Reviewed

    Kim JH, Yamaori S, Tanabe T, Takagi M, Matsubara T, Okamoto M, Kimura S, Gonzalez FJ

    Biochemical and biophysical research communications   491 ( 2 )   271 - 276   2017.09( ISSN:0006-291X

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    DOI: 10.1016/j.bbrc.2017.07.113

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  • St. John's Wort Attenuates Colorectal Carcinogenesis in Mice through Suppression of Inflammatory Signaling. Reviewed

    Manna SK, Golla S, Golla JP, Tanaka N, Cai Y, Takahashi S, Krausz KW, Matsubara T, Korboukh I, Gonzalez FJ

    Cancer prevention research (Philadelphia, Pa.)   8 ( 9 )   786 - 95   2015.09( ISSN:1940-6207

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    DOI: 10.1158/1940-6207.CAPR-14-0113

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  • Differential Proteome Analysis Identifies TGF-beta-Related Pro-Metastatic Proteins in a 4T1 Murine Breast Cancer Model Reviewed

    Sato Misako, Matsubara Tsutomu, Adachi Jun, Hashimoto Yuuki, Fukamizu Kazuna, Kishida Marina, Yang Yu-an, Wakefield Lalage M., Tomonaga Takeshi

    PLOS ONE   10 ( 5 )   e0126483   2015.05( ISSN:1932-6203

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    DOI: 10.1371/journal.pone.0126483

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  • Involvement of hepatic stellate cell cytoglobin in acute hepatocyte damage through the regulation of CYP2E1-mediated xenobiotic metabolism Reviewed

    Teranishi Yuga, Matsubara Tsutomu, Krausz Kristopher W., Le Thi T. T., Gonzalez Frank J., Yoshizato Katsutoshi, Ikeda Kazuo, Kawada Norifumi

    LABORATORY INVESTIGATION   95 ( 5 )   515 - 524   2015.05( ISSN:0023-6837

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/labinvest.2015.29

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  • Expression of Stanniocalcin 1 in Thyroid Side Population Cells and Thyroid Cancer Cells Reviewed

    Hayase Suguru, Sasaki Yoshihito, Matsubara Tsutomu, Seo Daekwan, Miyakoshi Masaaki, Murata Tsubasa, Ozaki Takashi, Kakudo Kennichi, Kumamoto Kensuke, Ylaya Kris, Cheng Sheue-yann, Thorgeirsson Snorri S., Hewitt Stephen M., Ward Jerrold M., Kimura Shioko

    THYROID   25 ( 4 )   425 - 436   2015.04( ISSN:1050-7256

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    DOI: 10.1089/thy.2014.0464

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  • Adipocyte-specific disruption of fat-specific protein 27 causes hepatosteatosis and insulin resistance in high-fat diet-fed mice. Reviewed

    Tanaka N, Takahashi S, Matsubara T, Jiang C, Sakamoto W, Chanturiya T, Teng R, Gavrilova O, Gonzalez FJ

    The Journal of biological chemistry   290 ( 5 )   3092 - 105   2015.01( ISSN:0021-9258

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    DOI: 10.1074/jbc.M114.605980

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  • Role of white adipose lipolysis in the development of NASH induced by methionine- and choline-deficient diet Reviewed

    Tanaka Naoki, Takahashi Shogo, Fang Zhong-Ze, Matsubara Tsutomu, Krausz Kristopher W., Qu Aijuan, Gonzalez Frank J.

    BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS   1841 ( 11 )   1596 - 1607   2014.11( ISSN:1388-1981

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    DOI: 10.1016/j.bbalip.2014.08.015

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  • Biomarkers of coordinate metabolic reprogramming in colorectal tumors in mice and humans. Reviewed

    Manna SK, Tanaka N, Krausz KW, Haznadar M, Xue X, Matsubara T, Bowman ED, Fearon ER, Harris CC, Shah YM, Gonzalez FJ

    Gastroenterology   146 ( 5 )   1313 - 24   2014.05( ISSN:0016-5085

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1053/j.gastro.2014.01.017

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  • An Efficient Method for Differentiation of Human Induced Pluripotent Stem Cells into Hepatocyte-like Cells Retaining Drug Metabolizing Activity Reviewed

    KONDO Yuki, IWAO Takahiro, NAKAMURA Katsunori, SASAKI Takamitsu, TAKAHASHI Shogo, KAMADA Noboru, MATSUBARA Tsutomu, GONZALEZ Frank J., AKUTSU Hidenori, MIYAGAWA Yoshitaka, OKITA Hajime, KIYOKAWA Nobutaka, TOYODA Masashi, UMEZAWA Akihiro, NAGATA Kiyoshi, MATSUNAGA Tamihide, OHMORI Shigeru

    日本薬物動態学会 Drug Metabolism and Pharmacokinetics   29 ( 3 )   237 - 243   2014

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    The use of human induced pluripotent stem (iPS) cells would be of great value for a variety of applications involving drug development studies. Several reports have been published on the differentiation of human iPS cells into hepatocyte-like cells; however, the cells were insufficient for application in drug metabolism studies. In this study, we aimed to establish effective methods for differentiation of human iPS cells into hepatocytes. Two human iPS cell lines were differentiated by addition of activin A, dimethyl sulfoxide, hepatocyte growth factor, oncostatin M, and dexamethasone. The differentiated cells expressed hepatocyte markers and drug-metabolizing enzymes, revealing that the human iPS cells were differentiated into hepatocyte-like cells. Expression of CYP3A4 and UGT1A1 mRNAs increased with treatment with typical inducers of the enzymes, and the response of the cells against the inducers was similar to that of human hepatocytes. Furthermore, the drug-metabolizing activity of CYP3A4, as monitored by testosterone 6β-hydroxylase activity, was elevated by these inducers. In conclusion, we established methods for differentiation of hepatocyte-like cells expressing drug metabolizing activity from human iPS cells. The hepatocyte-like cells derived from human iPS cells will be useful for drug metabolism studies.

    DOI: 10.2133/dmpk.DMPK-13-RG-104

    CiNii Article

  • Secretoglobin Superfamily Protein SCGB3A2 Deficiency Potentiates Ovalbumin-Induced Allergic Pulmonary Inflammation Reviewed

    Kido Taketomo, Yoneda Mitsuhiro, Cai Yan, Matsubara Tsutomu, Ward Jerrold M., Kimura Shioko

    MEDIATORS OF INFLAMMATION   2014   216465   2014( ISSN:0962-9351

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1155/2014/216465

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  • Stress influences on bile acid homeostasis in development of diet-induced steatohepatitis Reviewed

    Matsubara Tsutomu, Kitamura Kenji, Teranishi Yuga, Kawada Norifumi, Ikeda Kazuo

    HEPATOLOGY   58   550A - 550A   2013.10( ISSN:0270-9139

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  • Cholestasis induces reversible accumulation of periplakin in mouse liver Reviewed

    Ito Shinji, Satoh Junko, Matsubara Tsutomu, Shah Yatrik M., Ahn Sung-hoon, Anderson Cherie R., Shan Weiwei, Peters Jeffrey M., Gonzalez Frank J.

    BMC GASTROENTEROLOGY   13   116   2013.07( ISSN:1471-230X

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/1471-230X-13-116

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  • FXR signaling in the enterohepatic system. Reviewed

    Matsubara T, Li F, Gonzalez FJ

    Molecular and cellular endocrinology   368 ( 1-2 )   17 - 29   2013.04( ISSN:0303-7207

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    DOI: 10.1016/j.mce.2012.05.004

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  • Human PXR modulates hepatotoxicity associated with rifampicin and isoniazid co-therapy. Reviewed

    Li F, Lu J, Cheng J, Wang L, Matsubara T, Csanaky IL, Klaassen CD, Gonzalez FJ, Ma X

    Nature medicine   19 ( 4 )   418 - 20   2013.04( ISSN:1078-8956

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/nm.3104

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  • Role of PPARα and HNF4α in stress-mediated alterations in lipid homeostasis. Reviewed

    Konstandi M, Shah YM, Matsubara T, Gonzalez FJ

    PloS one   8 ( 8 )   e70675   2013

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1371/journal.pone.0070675

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  • Mechanisms of CYP3A Induction by Glucocorticoids in Human Fetal Liver Cells Reviewed

    Matsunaga Tamihide, Maruyama Masataka, Matsubara Tsutomu, Nagata Kiyoshi, Yamazoe Yasushi, Ohmori Shigeru

    The Japanese Society for the Study of Xenobiotics DRUG METABOLISM AND PHARMACOKINETICS   27 ( 6 )   653 - 657   2012.12( ISSN:1347-4367

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    Human fetal liver (HFL) cells express major drug metabolic enzymes CYP3A4, CYP3A5 and CYP3A7. In the fetal hepatocytes, betamethasone and dexamethasone (DEX) markedly enhanced the expression levels of CYP3A4 and CYP3A7 mRNAs and slightly increased the expression level of CYP3A5 mRNA. Interestingly, a high correlation between the CYP3A induction ability and the intensity of anti-inflammatory effect was observed. Human glucocorticoid receptor (GR)–small interfering RNA clearly attenuated the expression level of GR mRNA, and diminished the DEX-stimulated CYP3A4, CYP3A5 and CYP3A7 expression in HFL cells. These findings indicate that GR mediates the induction of CYP3A4 and CYP3A7 expression in human fetal hepatocytes as well as the CYP3A5.<br>

    DOI: 10.2133/dmpk.DMPK-12-NT-018

    CiNii Article

  • TGF-beta-SMAD3 signaling mediates hepatic bile acid and phospholipid metabolism following lithocholic acid-induced liver injury Reviewed

    Matsubara Tsutomu, Tanaka Naoki, Sato Misako, Kang Dong Wook, Krausz Kristopher W., Flanders Kathleen C., Ikeda Kazuo, Luecke Hans, Wakefield Lalage M., Gonzalez Frank J.

    JOURNAL OF LIPID RESEARCH   53 ( 12 )   2698 - 2707   2012.12( ISSN:0022-2275

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    DOI: 10.1194/jlr.M031773

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  • Metabolomics identifies an inflammatory cascade involved in dioxin- and diet-induced steatohepatitis.

    Cell Metabolism   16 ( 5 )   634 - 644   2012.11

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    Publishing type:Research paper (scientific journal)  

  • Disruption of phospholipid and bile acid homeostasis in mice with nonalcoholic steatohepatitis. Reviewed

    Tanaka N, Matsubara T, Krausz KW, Patterson AD, Gonzalez FJ

    Hepatology (Baltimore, Md.)   56 ( 1 )   118 - 29   2012.07( ISSN:0270-9139

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/hep.25630

    PubMed

  • Peroxisome proliferator-activated receptor alpha induction of uncoupling protein 2 protects against acetaminophen-induced liver toxicity. Reviewed

    Patterson AD, Shah YM, Matsubara T, Krausz KW, Gonzalez FJ

    Hepatology (Baltimore, Md.)   56 ( 1 )   281 - 90   2012.07( ISSN:0270-9139

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/hep.25645

    PubMed

  • Thyroid regeneration: characterization of clear cells after partial thyroidectomy. Reviewed

    Ozaki T, Matsubara T, Seo D, Okamoto M, Nagashima K, Sasaki Y, Hayase S, Murata T, Liao XH, Hanson J, Rodriguez-Canales J, Thorgeirsson SS, Kakudo K, Refetoff S, Kimura S

    Endocrinology   153 ( 5 )   2514 - 25   2012.05( ISSN:0013-7227

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1210/en.2011-1365

    PubMed

  • Suppression of hepatocyte proliferation by hepatocyte nuclear factor 4α in adult mice. Reviewed

    Bonzo JA, Ferry CH, Matsubara T, Kim JH, Gonzalez FJ

    The Journal of biological chemistry   287 ( 10 )   7345 - 56   2012.03( ISSN:0021-9258

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1074/jbc.M111.334599

    PubMed

  • Expression and regulation of human fetal-specific CYP3A7 in mice. Reviewed

    Pang XY, Cheng J, Kim JH, Matsubara T, Krausz KW, Gonzalez FJ

    Endocrinology   153 ( 3 )   1453 - 63   2012.03( ISSN:0013-7227

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1210/en.2011-1020

    PubMed

  • Mechanisms of CYP3A induction by glucocorticoids in human fetal liver cells. Reviewed

    Matsunaga T, Maruyama M, Matsubara T, Nagata K, Yamazoe Y, Ohmori S

    Drug metabolism and pharmacokinetics   27 ( 6 )   653 - 7   2012( ISSN:1347-4367

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    Publishing type:Research paper (scientific journal)  

    PubMed

  • Disruption of hypoxia-inducible factor 1 in adipocytes improves insulin sensitivity and decreases adiposity in high-fat diet-fed mice. Reviewed

    Jiang C, Qu A, Matsubara T, Chanturiya T, Jou W, Gavrilova O, Shah YM, Gonzalez FJ

    Diabetes   60 ( 10 )   2484 - 95   2011.10( ISSN:0012-1797

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.2337/db11-0174

    PubMed

  • Hypoxia-inducible transcription factor 2α promotes steatohepatitis through augmenting lipid accumulation, inflammation, and fibrosis. Reviewed

    Qu A, Taylor M, Xue X, Matsubara T, Metzger D, Chambon P, Gonzalez FJ, Shah YM

    Hepatology (Baltimore, Md.)   54 ( 2 )   472 - 83   2011.08( ISSN:0270-9139

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/hep.24400

    PubMed

  • Secretoglobin 3A2 suppresses bleomycin-induced pulmonary fibrosis by transforming growth factor beta signaling down-regulation. Reviewed

    Kurotani R, Okumura S, Matsubara T, Yokoyama U, Buckley JR, Tomita T, Kezuka K, Nagano T, Esposito D, Taylor TE, Gillette WK, Ishikawa Y, Abe H, Ward JM, Kimura S

    The Journal of biological chemistry   286 ( 22 )   19682 - 92   2011.06( ISSN:0021-9258

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1074/jbc.M111.239046

    PubMed

  • Hypoxia-inducible factor-2α mediates the adaptive increase of intestinal ferroportin during iron deficiency in mice. Reviewed

    Taylor M, Qu A, Anderson ER, Matsubara T, Martin A, Gonzalez FJ, Shah YM

    Gastroenterology   140 ( 7 )   2044 - 55   2011.06( ISSN:0016-5085

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1053/j.gastro.2011.03.007

    PubMed

  • Lithocholic acid disrupts phospholipid and sphingolipid homeostasis leading to cholestasis in mice. Reviewed

    Matsubara T, Tanaka N, Patterson AD, Cho JY, Krausz KW, Gonzalez FJ

    Hepatology (Baltimore, Md.)   53 ( 4 )   1282 - 93   2011.04( ISSN:0270-9139

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/hep.24193

    PubMed

  • PPARalpha-dependent activation of cell cycle control and DNA repair genes in hepatic nonparenchymal cells. Reviewed

    Qu A, Shah YM, Matsubara T, Yang Q, Gonzalez FJ

    Toxicological sciences : an official journal of the Society of Toxicology   118 ( 2 )   404 - 10   2010.12( ISSN:1096-6080

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/toxsci/kfq259

    PubMed

  • A novel role for the dioxin receptor in fatty acid metabolism and hepatic steatosis. Reviewed

    Lee JH, Wada T, Febbraio M, He J, Matsubara T, Lee MJ, Gonzalez FJ, Xie W

    Gastroenterology   139 ( 2 )   653 - 63   2010.08( ISSN:0016-5085

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1053/j.gastro.2010.03.033

    PubMed

  • Urinary metabolomics in Fxr-null mice reveals activated adaptive metabolic pathways upon bile acid challenge. Reviewed

    Cho JY, Matsubara T, Kang DW, Ahn SH, Krausz KW, Idle JR, Luecke H, Gonzalez FJ

    Journal of lipid research   51 ( 5 )   1063 - 74   2010.05( ISSN:0022-2275

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1194/jlr.M002923

    PubMed

  • Control of steroid 21-oic acid synthesis by peroxisome proliferator-activated receptor alpha and role of the hypothalamic-pituitary-adrenal axis. Reviewed

    Wang T, Shah YM, Matsubara T, Zhen Y, Tanabe T, Nagano T, Fotso S, Krausz KW, Zabriskie TM, Idle JR, Gonzalez FJ

    The Journal of biological chemistry   285 ( 10 )   7670 - 85   2010.03( ISSN:0021-9258

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1074/jbc.M109.090175

    PubMed

  • Unveiling a new essential cis element for the transactivation of the CYP3A4 gene by xenobiotics. Reviewed

    Toriyabe T, Nagata K, Takada T, Aratsu Y, Matsubara T, Yoshinari K, Yamazoe Y

    Molecular pharmacology   75 ( 3 )   677 - 84   2009.03( ISSN:0026-895X

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1124/mol.108.050575

    PubMed

  • Intestinal hypoxia-inducible transcription factors are essential for iron absorption following iron deficiency. Reviewed

    Shah YM, Matsubara T, Ito S, Yim SH, Gonzalez FJ

    Cell metabolism   9 ( 2 )   152 - 64   2009.02( ISSN:1550-4131

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.cmet.2008.12.012

    PubMed

  • Expression of a skin cholesterol sulfotransferase, St2b2, is a trigger of epidermal cell differentiation. Reviewed

    M Shimada, T Matsuda, A Sato, T Akase, T Matsubara, K Nagata, Y Yamazoe

    Xenobiotica; the fate of foreign compounds in biological systems   38 ( 12 )   1487 - 99   2008.12

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    Publishing type:Research paper (scientific journal)   International / domestic magazine:International journal  

    1. St2b2, a mouse cytosolic sulfotransferase, predominantly catalyses epidermal cholesterol sulfation. St2b2 was found in the basement layer by immunohistochemical analysis of normal mouse skin. The highest expression level was detected in epidermis from 3-day-old mice and then decreased before maturation. There was a good correlation between expression levels of skin St2b2 and a differentiation marker, involucrin. 2. To understand the role of St2b2 in epidermal cell differentiation, recombinant St2b2 was expressed in primary epidermal cells. The expression of St2b2 enhanced the involucrin expression with an increase of cholesterol sulfate. Furthermore, by down-regulation of the St2b2 gene expression, involucrin was decreased in dorsal skin of 1-3-day-old mice by 67% of the control. 3. These results strongly suggest a possibility that St2b2 expression plays a trigger of epidermal cell differentiation by controlling cholesterol sulfate level in the cells.

    DOI: 10.1080/00498250802488593

    PubMed

  • Role of vitamin D receptor in the lithocholic acid-mediated CYP3A induction in vitro and in vivo. Reviewed

    Matsubara T, Yoshinari K, Aoyama K, Sugawara M, Sekiya Y, Nagata K, Yamazoe Y

    Drug metabolism and disposition: the biological fate of chemicals   36 ( 10 )   2058 - 63   2008.10( ISSN:0090-9556

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1124/dmd.108.021501

    PubMed

  • Role of human hepatocyte nuclear factor 4alpha in the expression of drug-metabolizing enzymes and transporters in human hepatocytes assessed by use of small interfering RNA. Reviewed

    Kamiyama Y, Matsubara T, Yoshinari K, Nagata K, Kamimura H, Yamazoe Y

    Drug metabolism and pharmacokinetics   22 ( 4 )   287 - 98   2007.08( ISSN:1347-4367

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    PubMed

  • Broad but distinct role of pregnane x receptor on the expression of individual cytochrome p450s in human hepatocytes. Reviewed

    Kojima K, Nagata K, Matsubara T, Yamazoe Y

    Drug metabolism and pharmacokinetics   22 ( 4 )   276 - 86   2007.08( ISSN:1347-4367

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    Publishing type:Research paper (scientific journal)  

    PubMed

  • Assessment of human pregnane X receptor involvement in pesticide-mediated activation of CYP3A4 gene. Reviewed

    Matsubara T, Noracharttiyapot W, Toriyabe T, Yoshinari K, Nagata K, Yamazoe Y

    Drug metabolism and disposition: the biological fate of chemicals   35 ( 5 )   728 - 33   2007.05( ISSN:0090-9556

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1124/dmd.106.013144

    PubMed

  • Construction of several human-derived stable cell lines displaying distinct profiles of CYP3A4 induction. Reviewed

    Noracharttiyapot W, Nagai Y, Matsubara T, Miyata M, Shimada M, Nagata K, Yamazoe Y

    Drug metabolism and pharmacokinetics   21 ( 2 )   99 - 108   2006.04( ISSN:1347-4367

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    PubMed

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MISC

  • 肝疾患と微小環境 加齢関連肝疾患における肝星細胞の理解 Reviewed

    小田桐 直志, 松原 勤, 河田 則文

    肝臓   61 ( Suppl.1 )   A50 - A50   2020.04( ISSN:0451-4203 ( eISSN:1881-3593

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  • 細胞内温度イメージングに向けたワイドフィールド光検出電子スピン共鳴測定法の構築 Reviewed

    西村勇姿, 公文優花, 宮地冬, 松原勤, 湯川博, 馬場嘉信, 藤原正澄, 手木芳男

    応用物理学会春季学術講演会講演予稿集(CD-ROM)   66th   2019( ISSN:2436-7613

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    Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

    J-GLOBAL

  • 肝線維化病態進展におけるCYGB保護作用の分子機序解析 Reviewed

    松原三佐子, 松原三佐子, 翁良徳, 松原勤, 池田一雄, 吉里勝利, 河田則文

    日本臨床分子形態学会総会・学術集会講演プログラム・要旨集   51st   2019

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    J-GLOBAL

  • ヒト肝星細胞におけるサイトグロビン遺伝子発現制御と作用機序の解明 Reviewed

    大黒敦子, 松原三佐子, 松原三佐子, 松原勤, 池田一雄, 吉里勝利, 河田則文

    肝細胞研究会プログラム・抄録集   24th   2017

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    J-GLOBAL

  • FGF2はCytoglobinとαSMA遺伝子発現を制御し肝星細胞の脱活性化を促進する Reviewed

    松原三佐子, 松原三佐子, 大黒敦子, 松原勤, 池田一雄, 吉里勝利, 吉里勝利, 河田則文

    肝細胞研究会プログラム・抄録集   23rd   2016

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    J-GLOBAL

  • 肝星細胞におけるTGF-β1のCYGB発現抑制機構の解析 Reviewed

    翁良徳, 松原三佐子, 松原三佐子, 松原勤, 大黒敦子, 池田一雄, 吉里勝利, 吉里勝利, 河田則文

    肝細胞研究会プログラム・抄録集   23rd   2016

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    J-GLOBAL

  • HANDLING OF ACTIVATION STATUS OF HUMAN HEPATIC STELLATE CELLS BY LOW-MOLECULAR-WEIGHT FGF2 VIA THE INDUCTION OF CYTOGLOBIN Reviewed

    M. Sato-Matsubara, T. Matsubara, A. Daikoku, K. Ikeda, K. Rombouts, M. Pinzani, N. Kawada

    JOURNAL OF HEPATOLOGY   64   S711 - S711   2016( ISSN:0168-8278 ( eISSN:1600-0641

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    Publishing type:Research paper, summary (international conference)  

  • 肝星細胞脱活性化剤開発による肝硬変の肝機能改善と肝発がん予防 抗線維化物質の探索と慢性肝炎が惹起する肝発がん分子機序解析 Reviewed

    松原勤, 松原三佐子

    肝星細胞脱活性化剤開発による肝硬変の肝機能改善と肝発がん予防 平成25年度 総括・分担研究報告書   2014

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    J-GLOBAL

  • 実験材料及び評価系開発の最近の動向(第5回) 質量分析装置を用いた薬物動態研究の新たな展開医学・薬学研究におけるメタボロミクスの可能性 Reviewed

    松原 勤

    (一社)日本薬物動態学会 Drug Metabolism and Pharmacokinetics   26 ( 6 )   17 - 20   2011.12( ISSN:1347-4367

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    Publishing type:Article, review, commentary, editorial, etc. (scientific journal)   Kind of work:Single Work  

  • INVOLVEMENT OF PLURAL NUCLEAR RECEPTORS IN DRUG METABOLIZING GENE ACTIVATIONS

    Yasushi Yamazoe, Tsutomu Matsubara, Kiyoshi Nagata, Kouichi Yoshinari

    DRUG METABOLISM REVIEWS   40   17 - 17   2008( ISSN:0360-2532

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    Publishing type:Research paper, summary (international conference)  

  • UNVEILING A NEW ESSENTIAL CIS-ELELMENT FOR THE TRANSACTIVATION OF CYP3A4 GENE BY XENOBIOTICS

    Toriyabe Takayoshi, Takada Tomonari, Aratsu Yusuke, Matsubara Tsutomu, Yoshinari Kouichi, Nagata Kiyoshi, Yamazoe Yasushi

    Abstracts of JSSX meeting   23 ( 0 )   121 - 121   2008

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    Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

    DOI: 10.14896/jssxmeeting.23.0.121.0

    CiNii Article

  • ROLE OF VITAMIN D RECEPTOR IN THE LITHOCHOLIC ACID-MEDIATED CYP3A INDUCTION

    Matsubara Tsutomu, Yoshinari Kouichi, Aoyama Kazunobu, Sugawara Mika, Sekiya Yuji, Nagata Kiyoshi, Yamazoe Yasushi

    Abstracts of JSSX meeting   23 ( 0 )   325 - 325   2008

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    Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

    DOI: 10.14896/jssxmeeting.23.0.325.0

    CiNii Article

  • A NOVEL CIS-ELEMENT ESSENTIAL FOR THE TRANSACTIVATION OF THE CYP3A4 GENE IN RESPONSE TO RIFAMPICIN

    Takayoshi Toriyabe, Tomonari Takada, Yusuke Aratsu, Tsutomu Matsubara, Kouichi Yoshinari, Kiyoshi Nagata, Yasushi Yamazoe

    DRUG METABOLISM REVIEWS   39   139 - 139   2007( ISSN:0360-2532

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    Publishing type:Research paper, summary (international conference)  

  • DIFFERENCE IN INVOLVEMENT OF ER-6 ELEMENT ON VDR- AND PXR-MEDIATED ACTIVATION OF CYP3A4

    Kazutaka Sekiguchi, Ryu-ta Asaumi, Tsutomu Matsubara, Takayoshi Toriyabe, Kiyoshi Nagata, Kouichi Yoshinari, Yasushi Yamazoe

    DRUG METABOLISM REVIEWS   39   41 - 42   2007( ISSN:0360-2532

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  • UTILIZATION OF SMALL INTERFERING RNA TECHNIQUE TO ASSESS A ROLE OF HEPATOCYTE NUCLEAR FACTOR 4A. IN THE EXPRESSION OF DRUG-METABOLIZING ENZYMES AND TRANSPORTERS IN HUMAN HEPATOCYTES

    Yoshiteru Kamiyama, Tsutomu Matsubara, Kouichi Yoshinari, Kiyoshi Noguchi, Kiyoshi Nagata, Hidetaka Kamimura, Yasushi Yamazoe

    DRUG METABOLISM REVIEWS   39   230 - 230   2007( ISSN:0360-2532

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Presentations

  • LawsoneはYAPシグナルを減弱することで肝線維化を抑制する Domestic conference

    松原 勤、大黒 敦子、松原 三佐子、湯浅 秀人、宇留島 隼人、河田 則文、池田 一雄

    第144回日本薬学会年会  2024.03 

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    Venue:神奈川県横浜市  

  • Search for genes involved in proliferation of intrahepatic cholangiocarcinoma using clinical samples International conference

    Etsushi Kawamura, Tsutomu Matsubara, Naoshi Odagiri, Kohei Kotani, Atsuko Daikoku, Chiho Kadono, Hideto Yuasa, Ritsuzo Kozuka, Atsushi Hagihara, Hideki Fujii, Sawako Uchida-Kobayashi, Takeshi Izawa, Masaru Enomoto, Kazuo Ikeda, Norifumi Kawada

    The 33rd Annual Meeting of the Asian Pacific Association for the Study of the Liver  2024.03 

  • CHOP-Mediated FOS Expression Can Be Involved In Protection Against Acetaminophen-Induced Liver Injury Domestic conference

    2024.03 

  • Unveiling of Epithelial Membrane Protein 1 function in Nonalcoholic steatohepatitis and hepatocellular carcinoma Domestic conference

    2024.03 

  • 肝線維化におけるLawsone結合タンパク質の同定ならびに機能解析 Domestic conference

    大黒 敦子、松原 勤、松原 三佐子、湯浅 秀人、宇留島 隼人、河田 則文、池田 一雄

    第129回日本解剖学会総会・全国学術集会  2024.03 

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    Venue:沖縄県那覇市  

  • 活性型肝星細胞の生体内における三次元的構造解析 Domestic conference

    湯浅 秀人、宇留島 隼人、大黒 敦子、松原 勤、池田 一雄

    第129回日本解剖学会総会・全国学術集会  2024.03 

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    Venue:沖縄県那覇市  

  • 老化肝星細胞におけるERKリン酸化亢進とSMAD4発現抑制の分子機序解明 Domestic conference

    中居 暉、松原 勤、宇留島 隼人、湯浅 秀人、池田 一雄

    第37回肝類洞壁細胞研究会学術集会  2023.12 

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    Venue:東京都  

  • 肝細胞脂質代謝におけるプリオンの機能解析 Domestic conference

    辜 瓊雅、宇留島 隼人、松原 勤、湯浅 秀人、大黒 敦子、Hung Vu Thai、Nguyen Duc Vien、安藤 美玖、中居 暉、池田 一雄

    第37回肝類洞壁細胞研究会学術集会  2023.12 

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    Venue:東京都  

  • 増殖様式が異なるHepG2細胞2系統間の遺伝子発現比較と肝機能改善剤スクリーニングシステムの構築 Domestic conference

    宇留島隼人、松原勤、湯浅秀人、大黒敦子、Gu Qiongya、Hung Vu Thai、Nguyen Duc Vien、安藤美玖、中居暉、池田一雄

    第37回肝類洞壁細胞研究会学術集会  2023.12 

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    Venue:東京都  

  • 肝内胆管癌の臨床検体から抽出したmicroRNA-3648と癌抑制遺伝子SKIの関係 Domestic conference

    川村 悦史、松原 勤、大黒 敦子、武藤 芳美、小田桐 直志、元山 宏行、小谷 晃平、小塚 立蔵、萩原 淳司、藤井 英樹、打田 佐和子、榎本 大、池田 一雄、河田 則文

    第45回日本肝臓学会西部会  2023.12 

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    Venue:京都府  

  • クロソーム型エポキシドホドロラーゼによる肝線維化機序の解明 Domestic conference

    池永 寛子、松原 勤、河田 則文

    第31回日本消化器関連学会週間  2023.11 

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    Venue:兵庫県神戸市  

  • 老化肝星細胞におけるERKリン酸化亢進の意義 Domestic conference

    中居 暉、松原 勤、高田 さゆり、安藤 美玖、宇留島 隼人、湯浅 秀人、池田 一雄

    第30回肝細胞研究会  2023.08 

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    Venue:鹿児島県  

  • 肝星細胞のスパイン形成および活性化抑制に関わる細胞膜タンパク質の同定と機能解明 Domestic conference

    井上 喜来々、松原 三佐子、松原 勤、宇留島 隼人、湯浅 秀人、大黒 敦子、池田 一雄、吉里 勝利、河田 則文、鈴木孝幸

    第30回肝細胞研究会  2023.08 

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    Venue:鹿児島県  

  • 非アルコール性脂肪肝炎の病態変化に関連した因子の探索 Domestic conference

    安藤美玖、松原勤、大黒敦子、VU THAI HUNG、門野千穂、湯浅秀人、宇留島隼人、池田一雄

    第30回肝細胞研究会  2023.08 

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    Venue:鹿児島県  

  • Aged-Related Changes in Hepatic Mesenchymal Cells (HMCs) Domestic conference

    Nguyen Duc Vien, Tsutomu Matsubara, Atsuko Daikoku, Miku Ando, Chiho Kadono, Moe Higuchi, Hikaru Nakai, Hideto Yuasa, Hayato Urushima, Kazuo Ikeda

    2023.07 

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    Presentation type:Poster presentation  

  • Gene Expression Analysis Related to Pathological Changes in Non-alcoholic Steatohepatitis Domestic conference

    Vu Thai Hung, Tsutomu Matsubara, Atsuko Daikoku, Miku Ando, Chiho Kadono, Moe Higkuchi, Hideto Yuasa, Hayato Urushima, Kazuo Ikeda

    2023.07 

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    Presentation type:Poster presentation  

  • Induction of apoptosis in hepatocellular carcinoma-derived cells by Oligonol®, a low-molecular-weight polyphenol derived from lychee fruit International conference

    Hideto Yuasa, Hayato Urushima, Tsutomu Matsubara, Kazuo Ikeda

    The 31st Annual Meeting of International Congress on Nutrition and Integrative Medicine  2023.07 

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  • Hepatocyte Regeneration-Promoting Effects of AHCCⓇ in a Partial Hepatectomy Model International conference

    Qiongya Gu, Hayato Urushima,Chiho Kadono,Atsuko Daikoku, Hideto Yuasa,Tsutomu Matsubara,Kazuo Ikeda

    The 31st Annual Meeting of International Congress on Nutrition and Integrative Medicine  2023.07 

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  • AHCC® inhibited hepatic stellate cells activation by induction of cytoglobin expression through Toll-like receptor 2-JNK pathway and suppressed liver fibrosis International conference

    Hayato Urushima, Tsutomu Matsubara, Gu Qiongya, Atsuko Daikoku, Chiho Kadono, Hideto Yuasa, Kazuo Ikeda

    The 31st Annual Meeting of International Congress on Nutrition and Integrative Medicine  2023.07 

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  • NAFLD患者サンプル及びNASHモデルマウスを使用した肝線維化に関連する脂肪酸代謝経路の同定~リピドミクス解析によるアプローチ~

    池永 寛子、松原 勤、河田 則文

    第59回日本肝臓学会総会  2023.06 

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  • Gene expression analysis related to pathological changes in non-alcoholic steatohepatitis Domestic conference

    Vu Thai Hung、松原勤、大黒敦子、安藤美玖、門野千穂、樋口萌、湯浅秀人、宇留島隼人、池田一雄

    2023.03 

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  • Lawsoneが示す抗線維化作用機序の解明 Domestic conference

    大黒敦子、松原勤、松原三佐子、湯浅秀人、宇留島隼人、河田則文、池田一雄

    第128回日本解剖学会総会・全国学術集会  2023.03 

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  • Age-related changes in hepatic mesenchymal cells Domestic conference

    Nguyen Duc Vien、松原勤、大黒敦子、安藤美玖、門野千穂、中居暉、湯浅秀人、宇留島隼人、池田一雄

    2023.03 

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  • 肝転移におけるがん細胞‐肝類洞内皮細胞相互作用機構の解明 Domestic conference

    Huu Hoang Truong、松原三佐子、湯浅秀人、Le Thi Thanh Thuy、松原勤、池田一雄、吉里勝利、河田則文

    第36回肝類洞壁細胞研究会学術集会  2022.12 

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  • 肝細胞膜による肝星細胞活性化抑制作用 Domestic conference

    井上喜来々、松原三佐子、松原勤、宇留島隼人、湯浅秀人、大黒敦子、池田一雄、吉里勝利、鈴木孝幸、河田則文

    第36回肝類洞壁細胞研究会学術集会  2022.12 

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  • 電子顕微鏡を用いた肝類洞壁構成細胞の三次元的構造解析 Domestic conference

    湯浅秀人、太田啓介、大黒敦子、宇留島隼人、松原勤、池田一雄

    第36回肝類洞壁細胞研究会学術集会  2022.12 

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  • 肝細胞と肝星細胞との細胞膜を介した直接的なクロストーク Domestic conference

    井上喜来々、松原三佐子、松原勤、宇留島隼人、湯浅秀人、大黒敦子、池田一雄、吉里勝利鈴木孝幸、河田則文

    第45回日本分子生物学会年会  2022.11 

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  • 肝細胞膜による肝星細胞の脱活性化機構の解明 Domestic conference

    井上喜来々、松原三佐子、松原勤、宇留島隼人、湯浅秀人、大黒敦子、池田一雄、吉里勝利、河田則文

    第29回日本門脈圧亢進症学会総会  2022.09 

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  • 抗線維化薬としてのLawsoneの評価と作用機序の解明 Domestic conference

    大黒敦子、松原勤、松原三佐子、湯浅秀人、宇留島隼人、河田則文、池田一雄

    第29回肝細胞研究会  2022.08 

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  • 肝細胞の肝星細胞活性化抑制作用における肝細胞膜の重要性 Domestic conference

    井上喜来々、松原三佐子、松原勤、宇留島隼人、湯浅秀人、大黒敦子、池田一雄、吉里勝利鈴木孝幸、河田則文

    第29回肝細胞研究会  2022.08 

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  • Oligonol, a standardized oligomerized-polyonenol from Litchi chinensis fruit extract, incrases E-cadherin expression in hepatocyte International conference

    Hideto Yuasa, Hayato Urushima, Tsutomu Matsubara, Kazuo Ikeda

    2022.07 

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  • AHCCⓇ inhibited hepatic stellate cells activation and suppressed liver fibrosis progression via induction of cytoglobin International conference

    Hayato Urushima, Hideto Yuasa, Tsutomu Matsubara, and Kazuo Ikeda

    2022.07 

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  • 肝硬変治療薬を目指した化合物スクリーニングとその分子機序解析 Domestic conference

    松原勤、大黒敦子、池田一雄

    第58回日本肝臓学会総会  2022.06 

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  • 肝星細胞の微小突起形成におけるCdc42の役割ついて Domestic conference

    湯浅秀人、宇留島隼人、松原勤、池田一雄

    第127回日本解剖学会総会・全国学術集会  2022.03 

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  • アセトアミノフェン誘発急性肝炎におけるC/EBP homologous proteinの役割 Domestic conference

    樋口萌、松原勤、湯浅秀人、宇留島隼人、池田一雄

    第127回日本解剖学会総会・全国学術集会  2022.03 

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  • 肝星細胞の活性化時における上皮-間葉転換と機能変化との相関 Domestic conference

    宇留島隼人、和氣健二郎、湯浅秀人、松原勤、池田一雄

    第127回日本解剖学会総会・全国学術集会  2022.03 

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  • Cytoglobin欠損マウスの肝星細胞に由来する一酸化窒素は肝細胞のミトコンドリア機能障害を引き起こす Domestic conference

    翁良徳、松原三佐子、宇留島隼人、松原勤、池田一雄、吉里勝利、河田則文

    第35回肝類洞壁細胞研究会  2021.12 

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  • 肝星細胞の微小突起形成機構について Domestic conference

    湯浅秀人,宇留島隼人,松原勤,池田一雄

    第35回肝類洞壁細胞研究会  2021.12 

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  • 上皮-間葉転換に着目した新規肝星細胞脱活性化候補化合物の探索 Domestic conference

    宇留島隼人 松原勤 湯浅秀人 和氣健二郎 池田一雄

    第35回肝類洞壁細胞研究会  2021.12 

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  • 肝星細胞と肝実質細胞との相関関係 Domestic conference

    和氣健二郎、宇留島隼人、湯浅秀人、松原勤、池田一雄

    第35回肝類洞壁細胞研究会  2021.12 

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  • 肝細胞と肝星細胞との細胞膜を介した直接的なクロストーク Domestic conference

    井上喜来々、松原三佐子、Truong Huu Hoang、松原勤、宇留島隼人、湯浅秀人

    第28回肝細胞研究会   2021.09 

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  • 胆管癌の臨床検体から抽出した癌抑制遺伝子による細胞増殖抑制:SKI-p21waf/cip1シグナルについて Domestic conference

    川村悦史、松原勤、河田則文

    第57回日本肝臓学会総会  2021.06 

  • The organic networks for hepatic lipid homeostasis Invited Domestic conference

    2021.03 

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  • 職業性肝内胆管癌組織を使った癌遺伝子の探索 Domestic conference

    川村悦史, 松原勤, 他18名

    第56回日本肝癌研究会  2020.12 

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  • 肝細胞との接着結合による肝星細胞活性抑制と肝機能単位 Stellonの再認識 Domestic conference

    宇留島隼人, 湯浅秀人, 松原 勤, 井上孝二, 和氣健二郎, 佐藤哲二, 池田一雄

    第34回肝類洞壁細胞研究会学術集会  2020.12 

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  • 肝星細胞の培養条件下における静止型形態の維持について Domestic conference

    湯浅秀人, 宇留島隼人, 髙山実紗子, 松原 勤, 池田一雄

    第34回肝類洞壁細胞研究会学術集会  2020.12 

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  • Intracellular gap formation of the liver sinusoidal endothelial cells facilitates the liver metastasis ability of cancer Domestic conference

    チュンフーホアン, 松原三佐子, 湯浅秀人, 松原勤, 宇留島隼人, リーツイ, 大黒敦子, 翁良徳, 吉里勝利, 河田則文

    第34回肝類洞壁細胞研究会学術集会  2020.12 

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  • 加齢関連肝疾患における肝星細胞の理解 Domestic conference

    小田桐直志, 松原勤, 河田則文

    第56回日本肝臓学会総会  2020.08 

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  • 肝線維老化肝星細胞におけるTGFβシグナルの変化 Domestic conference

    松原 勤、高田 さゆり、小田桐 直志、宇留島 隼人、河田 則文、池田 一雄

    第125回日本解剖学会総会・全国学術集会  2020.03 

  • 老化肝星細胞におけるTGFβシグナル変化についての解析 Domestic conference

    高田 さゆり, 松原 勤, 樋口 萌, 小田桐 直志, 松原 三佐子, 河田 則文, 池田 一雄

    第43回日本肝臓学会西部会  2019.12  (一社)日本肝臓学会

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  • 若年胆管癌組織を使った癌抑制遺伝子の探索 Domestic conference

    川村 悦史, 松原 勤, 樋口 萌, 出口 早苗, 高田 さゆり, 大黒 敦子, 伊藤 得路, 木下 正彦, 松原 三佐子, 小田桐 直志, 田中 肖吾, 竹村 茂一, 村上 善基, 榎本 大, 田守 昭博, 久保 正二, 祝迫 惠子, 池田 一雄, 河田 則文

    第43回日本肝臓学会西部会  2019.12  (一社)日本肝臓学会

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  • 非アルコール性脂肪性肝炎におけるCytoglobin発現制御機構 Domestic conference

    翁 良徳、松原三佐子、松原 勤、大黒 敦子、池田 一雄、吉里 勝利、河田 則文

    第33回肝類洞壁細胞研究会  2019.11 

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  • 正常肝ないし障害肝の肝星細胞におけるfilopodia関連タンパク質の発現解析 Domestic conference

    湯浅秀人、宇留島隼人、松原勤、池田一雄

    第33回肝類洞壁細胞研究会  2019.11 

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  • 肝がん・肝硬変における肝星細胞の多面的理解 Invited Domestic conference

    松原 勤

    第33回肝類洞壁細胞研究会  2019.11 

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  • Downregulation of cytoglobin by TGF-β leads to hydroxyl radical-induced oxidative DNA damage in human HSCs. International conference

    Okina Y, Sato-Matsubara M, Matsubara T, Daikoku A, Rombouts K, Fujii H, Ikeda K, Pinzani M, Kawada N.

    JSH:International Liver Conference 2019  2019.10 

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  • 病態進展におけるCYGB保護作用の分子機序解析 Invited Domestic conference

    松原三佐子、翁 良徳、松原 勤、池田 一雄、吉里 勝利、河田 則文

    第51回日本臨床分子形態学会総会・学術集会  2019.09 

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  • 肝硬変時の低ナトリウム血症による低浸透圧環境が門脈圧亢進に及ぼす影響 Domestic conference

    宇留島 隼人, 松原 勤, 湯浅 秀人, 河田 則文, 池田 一雄

    第26回日本門脈圧亢進症学会総会  2019.09  (一社)日本門脈圧亢進症学会

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  • 2. Stellate cells initiate the activation by the loss of adherence junction with hepatocytes. Domestic conference

    Urushima H, Yuasa H, Matsubara T, Hara Y, Inoue K, Wake K, Sato T, Ikeda K.

    20th International Symposium on Cells of Hepatic Sinusoid  2019.09 

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  • TGF-β1 transcriptionally repressed cytoglobin expression and enhanced H2O2-induced oxidative DNA damage in activated HSCs. International conference

    Sato-Matsubara M, Okina Y, Matsubara T, Daikoku A, Rombouts K, Thuy LTT, Fujii H, Ikeda K, Yoshizato K, Pinzani M, Kawada N.

    20th International Symposium on Cells of Hepatic Sinusoid  2019.09 

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  • Search for novel component with ability to suppress the hepatic stellate cell activation in AHCC. International conference

    Takayama M, Urushima H, Yuasa H, Matsubara T, Ikeda K.

    27th International Congress on Nutrition and Integrative Medicine  2019.07 

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  • Oligonol ameliorates hepatic fibrosis through the inhibition of FAK-YAP pathway in hepatic stellate cells. International conference

    Urushima H, Yuasa H, Takayama M, Matsubara T, Ikeda K.

    27th International Congress on Nutrition and Integrative Medicine  2019.07 

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  • NAFLD/NASHの病態進展における血清胆汁酸組成の影響 Domestic conference

    藤井 英樹, 松原 勤, 河田 則文

    第62回日本糖尿病学会年次学術集会  2019.05  (一社)日本糖尿病学会

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  • 老化肝星細胞におけるTGF-βシグナル変化の分子機序解析 Domestic conference

    松原勤、高田さゆり、小田桐直志、松原三佐子、大黒敦子、宇留島隼人、吉里勝利、河田則文、池田一雄

    第26回肝細胞研究会  2019.05 

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  • 直接的細胞接着に依存する肝細胞と星細胞の緊密な相互作用 Domestic conference

    松原 三佐子、谷口 絵美、松原 勤、宇留島隼人、大黒 敦子、森浦 芳枝、門野 千穂、池田 一雄 、和氣健二郎、河田 則文 、吉里 勝利

    第26回肝細胞研究会  2019.05 

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  • LawsoneはヒトCYGB遺伝子発現誘導作用を持つ抗線維化化合物である Domestic conference

    大黒 敦子、松原 勤、松原三佐子、池田 一雄、河田 則文

    第26回肝細胞研究会  2019.05 

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  • 肝細胞-肝星細胞間の接着結合喪失は肝星細胞活性化に寄与する Domestic conference

    宇留島隼人, 湯浅秀人, 松原勤, 井上孝二, 和氣健二郎, 佐藤哲二, 池田一雄

    第124回日本解剖学会総会  2019.03 

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  • 脂肪性肝炎の進展におけるCYGB保護作用の分子機序解析 Domestic conference

    松原三佐子, 翁良徳, 松原勤, 大黒敦子, 池田一雄, 吉里勝利, 河田則文

    第32回肝類洞壁細胞研究会  2018.12 

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  • 肝細胞 -肝星細胞間接着と星細胞活性化との関連 Domestic conference

    宇留島隼人, 松原勤, 湯浅秀人, 井上孝二, 和氣健二郎, 佐藤哲二, 池田一雄

    第32回肝類洞壁細胞研究会  2018.12 

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  • TGFβ1 reduces Cytoglobin expression via Smad2-SP3 pathway in human, but not mouse, hepatic stellate cells International conference

    Sato-Matsubara M, Okina Y, Matsubara T, Daikoku A, Fujii H, Rombouts K, Ikeda K, Yoshizato K, Pinzani M, Kawada N.

    AASLD single topic conference; Hepatic fibrosis   2018.09 

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  • FBLN5 could be a novel treatment target for elastic fibrosis in the liver International conference

    Yasui Y, Matsubara M, Fujii H, Enomoto M, Okina Y, Daikoku A, Matsubara T, Ikura Y, Kawamura E, Uchida-Kobayashi S, Murakami Y, Kawada N

    AASLD single topic conference; Hepatic fibrosis   2018.09 

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  • 肝細胞と肝星細胞の共培養による肝星細胞の活性化抑制 Domestic conference

    松原三佐子, 松原勤, 宇留島隼人, 大黒敦子, 森浦芳枝, 門野千穂, 池田一雄, 河田則文, 吉里勝利

    第25回肝細胞研究会  2018.07 

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  • ヒト肝星細胞における脱活性化誘導制御機構の解明 Domestic conference

    松原三佐子, 大黒敦子, 松原勤, 池田一雄, 吉里勝利, 河田則文

    第54回日本肝臓学会総会  2018.06 

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  • ヒト肝星細胞における老化関連分泌因子の遺伝子発現解析 Domestic conference

    松原 勤,小田桐 直志,河田 則文,池田 一雄

    第123回日本解剖学会総会  2018.03 

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  • 肝星細胞のspineを介した肝細胞との接着の意義 Domestic conference

    宇留島 隼人,松原 勤,井上 孝二,和氣 健二郎,佐藤 哲二,池田 一雄

    第123回日本解剖学会総会  2018.03 

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  • 低浸透圧環境は活性化星細胞や肝がん細胞のアポトーシスを抑制する Domestic conference

    宇留島 隼人,松原 勤,小田桐 直志,池田 一雄

    第31回肝類洞壁細胞研究会  2017.11 

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  • 肝星細胞におけるTGF-β1/Smadシグナルを介したCytoglobin発現制御機構 Domestic conference

    松原 三佐子,翁 良徳,松原 勤,大黒 敦子,池田 一雄,吉里 勝利,河田 則文

    第31回肝類洞壁細胞研究会  2017.11 

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  • ヒト肝星細胞の老化関連分泌表現型解析 Domestic conference

    小田桐 直志、松原 勤、河田 則文、池田 一雄

    第31回肝類洞壁細胞研究会  2017.11 

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    Presentation type:Oral presentation (general)  

  • ヒト肝星細胞の老化関連分泌表現型(SASP)解析 Domestic conference

    小田桐 直志, 松原 勤, 池田 一雄

    肝臓  2017.09  (一社)日本肝臓学会

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    Presentation type:Oral presentation (general)  

  • 肝星細胞の細胞老化に伴う遺伝子発現変化 Domestic conference

    松原 勤,小田桐 直志,樋口 萌,河田 則文,池田 一雄

    第24回肝細胞研究会  2017.06 

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    Presentation type:Poster presentation  

  • ヒト肝星細胞におけるサイトグロビン遺伝子発現制御と作用機序の解析 Domestic conference

    大黒 敦子,松原 三佐子,松原 勤,池田 一雄,吉里 勝利,河田 則文

    第24回肝細胞研究会  2017.06 

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    Presentation type:Poster presentation  

  • 肝星細胞を標的とした細胞表面抗原の樹立 Domestic conference

    吹田 安佐詠, 松原 三佐子, 松原 勤, 池田 一雄, 河田 則文

    肝臓  2017.04  (一社)日本肝臓学会

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    Presentation type:Oral presentation (general)  

  • 肝星細胞の脱活性化を誘導するサイトグロビン発現促進機構の解析 Domestic conference

    松原 三佐子, 大黒 敦子, 松原 勤, 池田 一雄, 河田 則文

    肝臓  2016.04  (一社)日本肝臓学会

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    Presentation type:Oral presentation (general)  

  • 肝星細胞によるサイトグロビンの発現に対する酸素分圧と基底膜成分の影響 Domestic conference

    沖田 大和, 松原 勤, 池田 一雄, 河田 則文, 吉里 勝利

    肝臓  2015.11  (一社)日本肝臓学会

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    Presentation type:Oral presentation (general)  

  • 抗線維化in vitro評価系の構築と抗線維化物質の探索 Domestic conference

    松原 勤, 大黒 敦子, 松原 三佐子, 池田 一雄, 河田 則文

    肝臓  2015.11  (一社)日本肝臓学会

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    Presentation type:Oral presentation (general)  

  • ヒト肝星細胞におけるサイトグロビン遺伝子発現調節機構の分子機序解析 Domestic conference

    松原 三佐子, 大黒 敦子, 松原 勤, 池田 一雄, 河田 則文

    肝臓  2015.11  (一社)日本肝臓学会

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    Presentation type:Oral presentation (general)  

  • 肝星細胞のサイトグロビンはアセトアミノフェンによる急性肝障害に関与する Domestic conference

    寺西 優雅, 松原 勤, 池田 一雄, 河田 則文

    肝臓  2014.04  (一社)日本肝臓学会

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    Presentation type:Oral presentation (general)  

  • メタボロミクスが明示した脂肪肝炎に関する炎症カスケード Domestic conference

    松原 勤, 田中 直樹, Gonzalez Frank

    日本薬学会年会要旨集  2013.03  (公社)日本薬学会

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    Presentation type:Oral presentation (general)  

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Industrial Property Rights

  • 線維症治療薬

    松原勤, 松原三佐子, 池田一雄, 河田則文

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    property_type:Patent 

    Application no:特願2020-174922 

  • 胆道癌又は膵癌治療剤

    川村悦史、松原勤、河田則文、池田一雄

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    property_type:Patent 

    Application no:特願2019-207404 

  • 乳がんの予防または治療剤及 び乳がん細胞の増殖抑制剤

    松原勤, 松原三佐子, 池田一雄, 河田則文

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    property_type:Patent 

    Application no:特願2019-052951 

  • 抗線維化剤

    河田則文, 池田一雄, 松原勤, 松原三佐子

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    property_type:Patent 

    Application no:特願2017-241997 

Grant-in-Aid for Scientific Research

  • Unmet Medical Needsである低アルブミン血症に対する改善候補化合物の分子機序解明

    Grant-in-Aid for Scientific Research(C)  2026

  • オルガネラ温度制御装置の開発:熱流体力学に基づいた細胞生理の解明を目指して

    挑戦的研究(萌芽)  2026

  • Unmet Medical Needsである低アルブミン血症に対する改善候補化合物の分子機序解明

    Grant-in-Aid for Scientific Research(C)  2025

  • オルガネラ温度制御装置の開発:熱流体力学に基づいた細胞生理の解明を目指して

    挑戦的研究(萌芽)  2025

  • Functions of the cholangiocarcinoma suppressor gene extracted from printing company workers' samples: From cell cycle regulation to drug discovery

    Grant-in-Aid for Scientific Research(C)  2024

  • Unmet Medical Needsである低アルブミン血症に対する改善候補化合物の分子機序解明

    Grant-in-Aid for Scientific Research(C)  2024

  • オルガネラ温度制御装置の開発:熱流体力学に基づいた細胞生理の解明を目指して

    挑戦的研究(萌芽)  2024

  • HSD17B4の新機能に着目した肝硬変治療薬の開発

    Grant-in-Aid for Scientific Research(B)  2024

  • 機能性ブロックポリペプチドを用いた臓器被膜の再構築

    挑戦的研究(萌芽)  2020.07

  • 生体内一細胞温度計測による定量熱生物学の開拓

    Grant-in-Aid for Scientific Research(A)  2020.04

  • 地元大阪の印刷所労働者胆管がん組織を使ったがん遺伝子の探索:創薬基盤の構築

    Grant-in-Aid for Scientific Research(C)  2019.04

  • 肝がんにおける肝星細胞形質転換の意義

    Grant-in-Aid for Scientific Research(C)  2018.04

  • 非アルコール性脂肪肝炎の慢性炎症形成における赤血球、血小板の役割

    Grant-in-Aid for Scientific Research(C)  2017.04

  • 肝硬変・肝がんにおける肝星細胞FXRの機能解析

    Grant-in-Aid for Young Scientists(B)  2017.04

  • 肝星細胞のエピジェネティクス制御と肝線維化に関する検討

    Grant-in-Aid for Scientific Research(C)  2016.04

  • 新規肝硬変治療薬の開発を目指した星細胞脱活性化の分子機序解析

    Grant-in-Aid for Scientific Research(C)  2015.04

  • 多面的網羅解析による胆汁酸受容体FXRの肝発がん抑制作用の分子機序解析

    Grant-in-Aid for Young Scientists(B)  2014.04

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Charge of on-campus class subject

  • 創薬科学のすすめ

    2024   Weekly class   Graduate school

  • 創薬科学のすすめ

    2024   Weekly class   Graduate school

  • 肉眼解剖(マクロ)実習

    2023    

  • 医学研究推進コース2

    2023    

  • 内分泌・代謝

    2023    

  • 消化器系

    2023    

  • 医学研究推進コース3

    2023    

  • 細胞と組織の基本構造と機能

    2023    

  • 医科学概論

    2023     Graduate school

  • 医科学概論

    2022     Graduate school

  • 細胞と組織の基本構造と機能

    2022    

  • 医学研究推進コース3

    2022    

  • 消化器系

    2022    

  • 内分泌・代謝

    2022    

  • 医学研究推進コース2

    2022    

  • 肉眼解剖(マクロ)実習

    2022    

  • 医科学概論

    2020     Graduate school

  • 細胞と組織の基本構造と機能コース

    2020     Undergraduate

  • 内分泌・代謝コース

    2020     Undergraduate

  • 肉眼解剖(マクロ)実習

    2020     Undergraduate

  • 内分泌・代謝コース

    2019     Undergraduate

  • 細胞と組織の基本構造と機能コース

    2019     Undergraduate

  • 医科学概論

    2019     Graduate school

  • 肉眼解剖学(マクロ)実習

    2019     Undergraduate

  • 医科学概論

    2018     Graduate school

  • 細胞と組織の基本構造と機能コース

    2018     Undergraduate

  • 内分泌・代謝コース

    2018     Undergraduate

  • 肉眼解剖学(マクロ)実習

    2018     Undergraduate

  • 医科学概論

    2017     Graduate school

  • 細胞と組織の基本構造と機能コース

    2017     Undergraduate

  • 内分泌・代謝コース

    2017     Undergraduate

  • 肉眼解剖学(マクロ)実習

    2017     Undergraduate

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