Updated on 2024/04/08

写真a

 
YAMAGISHI Ryota
 
Organization
Graduate School of Medicine Department of Basic Medical Science Lecturer
School of Medicine Department of Medical Science
Title
Lecturer
Affiliation
Institute of Medicine

Position

  • Graduate School of Medicine Department of Basic Medical Science 

    Lecturer  2023.10 - Now

  • Graduate School of Medicine Department of Basic Medical Science 

    Assistant Professor  2022.04 - 2023.09

  • School of Medicine Department of Medical Science 

    Lecturer  2023.10 - Now

  • School of Medicine Department of Medical Science 

    Assistant Professor  2022.04 - 2023.09

Degree

  • 博士(薬学) ( Nagoya City University )

Research Areas

  • Life Science / Tumor biology

Research Interests

  • がん微小環境、細胞老化、mRNA代謝

Research subject summary

  • 転写後調節を介したがん微小環境制御

Professional Memberships

  • 日本癌学会

      Domestic

Job Career (off-campus)

  • 愛知県がんセンター   分子腫瘍学部   リサーチレジデント

    2016.04 - 2017.09

Education

  • Nihon University     Graduated/Completed

  • Nagoya City University   The second semester of doctoral program   Graduated/Completed

Papers

  • 増大特集 代謝 Ⅲ.代謝とがん 腸内細菌叢成分の肝移行による肥満関連肝がんの進展機構 Reviewed

    山岸 良多, 大谷 直子

    生体の科学   74 ( 5 )   460 - 461   2023.10( ISSN:03709531 ( eISSN:18835503

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.11477/mf.2425201753

  • SMG6 regulates DNA damage and cell survival in Hippo pathway kinase LATS2-inactivated malignant mesothelioma. Reviewed

    Suzuki K, Tange M, Yamagishi R, Hanada H, Mukai S, Sato T, Tanaka T, Akashi T, Kadomatsu K, Maeda T, Miida T, Takeuchi I, Murakami H, Sekido Y, Murakami-Tonami Y

    Cell death discovery   8 ( 1 )   446   2022.11( ISSN:2058-7716

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41420-022-01232-w

    PubMed

  • Cancer cells produce liver metastasis via gap formation in sinusoidal endothelial cells through proinflammatory paracrine mechanisms. Reviewed

    Huu Hoang T, Sato-Matsubara M, Yuasa H, Matsubara T, Thuy LTT, Ikenaga H, Phuong DM, Hanh NV, Hieu VN, Hoang DV, Hai H, Okina Y, Enomoto M, Tamori A, Daikoku A, Urushima H, Ikeda K, Dat NQ, Yasui Y, Shinkawa H, Kubo S, Yamagishi R, Ohtani N, Yoshizato K, Gracia-Sancho J, Kawada N

    Science advances   8 ( 39 )   eabo5525   2022.09

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1126/sciadv.abo5525

    PubMed

  • Gasdermin D-mediated release of IL-33 from senescent hepatic stellate cells promotes obesity-associated hepatocellular carcinoma. Reviewed

    Yamagishi R, Kamachi F, Nakamura M, Yamazaki S, Kamiya T, Takasugi M, Cheng Y, Nonaka Y, Yukawa-Muto Y, Thuy LTT, Harada Y, Arai T, Loo TM, Yoshimoto S, Ando T, Nakajima M, Taguchi H, Ishikawa T, Akiba H, Miyake S, Kubo M, Iwakura Y, Fukuda S, Chen WY, Kawada N, Rudensky A, Nakae S, Hara E, Ohtani N

    Science immunology   7 ( 72 )   eabl7209   2022.06

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1126/sciimmunol.abl7209

    PubMed

  • Non-heat-stressed Method to Isolate Hepatic Stellate Cells From Highly Steatotic Tumor-bearing Liver Using CD49a. Reviewed

    Cheng Y, Yamagishi R, Nonaka Y, Sato-Matsubara M, Kawada N, Ohtani N

    Cellular and molecular gastroenterology and hepatology   14 ( 4 )   964 - 966.e9   2022

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.jcmgh.2022.07.006

    PubMed

  • The mechanism of SASP in obesity-associated liver tumor microenvironnment Reviewed

    Yamagishi Ryota, Kamachi Fumitaka, Cheng Yi, Hara Eiji, Ohtani Naoko

    CANCER SCIENCE   112   488 - 488   2021.02( ISSN:1347-9032

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    Publishing type:Research paper (scientific journal)  

  • Molecular mechanism of synthetic lethality induced by SMG6 inhibition in LATS2-mutated mesothelioma cells Reviewed

    Suzuki Koya, Yamagishi Ryota, Mukai Satomi, Tabe Yoko, Miida Takashi, Sekido Yoshitaka, Murakami-Tonami Yuko

    CANCER SCIENCE   112   628 - 628   2021.02( ISSN:1347-9032

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    Publishing type:Research paper (scientific journal)  

  • Gut microbial metabolite and obesity-associated liver cancer Reviewed

    Ohtani Naoko, Kamiya Tomonori, Kamachi Fumitaka, Yamagishi Ryota

    CANCER SCIENCE   112   1031 - 1031   2021.02( ISSN:1347-9032

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    Publishing type:Research paper (scientific journal)  

  • The RNA-binding protein QKI-7 recruits the poly(A) polymerase GLD-2 for 3' adenylation and selective stabilization of microRNA-122. Reviewed

    Hojo H, Yashiro Y, Noda Y, Ogami K, Yamagishi R, Okada S, Hoshino SI, Suzuki T

    The Journal of biological chemistry   295 ( 2 )   390 - 402   2020.01( ISSN:0021-9258

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1074/jbc.RA119.011617

    PubMed

  • SGO1 is involved in the DNA damage response in MYCN-amplified neuroblastoma cells. Reviewed

    Murakami-Tonami Y, Ikeda H, Yamagishi R, Inayoshi M, Inagaki S, Kishida S, Komata Y, Jan Koster, Takeuchi I, Kondo Y, Maeda T, Sekido Y, Murakami H, Kadomatsu K

    Scientific reports   6   31615   2016.08

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/srep31615

    PubMed

  • The STAR protein QKI-7 recruits PAPD4 to regulate post-transcriptional polyadenylation of target mRNAs. Reviewed

    Yamagishi R, Tsusaka T, Mitsunaga H, Maehata T, Hoshino S

    Nucleic acids research   44 ( 6 )   2475 - 90   2016.04( ISSN:0305-1048

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/nar/gkw118

    PubMed

  • Arsenite inhibits mRNA deadenylation through proteolytic degradation of Tob and Pan3. Reviewed

    Yamagishi R, Hosoda N, Hoshino S

    Biochemical and biophysical research communications   455 ( 3-4 )   323 - 31   2014.12( ISSN:0006-291X

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.bbrc.2014.11.015

    PubMed

  • Anti-proliferative protein Tob negatively regulates CPEB3 target by recruiting Caf1 deadenylase. Reviewed

    Hosoda N, Funakoshi Y, Hirasawa M, Yamagishi R, Asano Y, Miyagawa R, Ogami K, Tsujimoto M, Hoshino S

    The EMBO journal   30 ( 7 )   1311 - 23   2011.04( ISSN:0261-4189

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/emboj.2011.37

    PubMed

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MISC

  • 【代謝】代謝とがん 腸内細菌叢成分の肝移行による肥満関連肝がんの進展機構 Reviewed

    山岸 良多, 大谷 直子

    生体の科学   74 ( 5 )   460 - 461   2023.10( ISSN:0370-9531

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    Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

    <文献概要>腸内細菌叢は様々な代謝物質を産生し,それらが腸から吸収され,腸のみならず様々な遠隔臓器に影響を及ぼすことが明らかになっている。なかでも肝臓は,門脈などを介して腸内細菌関連因子がまず流れ込む臓器であり,腸内細菌叢の影響を受けやすい臓器と考えられる。筆者らは非アルコール性脂肪性肝炎関連肝がんの微小環境において,腸内細菌叢成分の肝移行により,肝がん促進的がん微小環境が形成されていることを見いだした。特に肝星細胞ががん関連線維芽細胞に変化し,細胞老化随伴分泌現象を起こす分子メカニズムの一端を明らかにした。

Presentations

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Grant-in-Aid for Scientific Research

  • パイロトーシス実行因子GSDMDを標的としたCAF化肝星細胞排除法の開発

    Grant-in-Aid for Scientific Research(C)  2025

  • パイロトーシス実行因子GSDMDを標的としたCAF化肝星細胞排除法の開発

    Grant-in-Aid for Scientific Research(C)  2024

  • 合成致死を利用した悪性中皮腫瘍新規治療標的の探索

    Grant-in-Aid for Young Scientists(B)  2017.04

Charge of on-campus class subject

  • 初年次ゼミナール

    2024   Weekly class   Graduate school