Organization
Graduate School of Medicine Department of Basic Medical Science Professor
School of Medicine Department of Medical Science
School of Medicine Department of Medical Science
Title
Professor
Affiliation
Institute of Medicine
HIROTUNE Shinji
Position
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Graduate School of Medicine Department of Basic Medical Science
Professor 2022.04 - Now
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School of Medicine Department of Medical Science
Professor 2022.04 - Now
Degree
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Doctor of Medical Science （ Osaka University ）
Research Areas
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Life Science / Medical biochemistry / Neuroscience
Research Interests
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neuronal degeneration
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intracellular transport
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neural development
Research subject summary
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ほ乳類の脳発生のメカニズム解明と神経疾患の原因遺伝子の探索。 形態形成を制御する遺伝子の機能解析と神経変性疾患のメカニズム解明。
Research Career
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Neuronal Development
Individual
1900.04
Job Career (off-campus)
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埼玉医科大学、ゲノム医学研究センター 神経疾患研究室 助教授
2001.08 - 2002.03
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動物遺伝研究所 主任研究員
1998.04 - 2001.07
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米国国立衛生研究所、ヒトゲノム研究センター 遺伝疾患研究室 ポストドクトラルフェロー
1995.04 - 1998.03
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理化学研究所 研究協力員
1993.04 - 1995.03
Education
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Osaka University Doctor's Course
1989.04 - 1993.03
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Osaka City University
1981.04 - 1987.03
Papers
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シヌクレイン変異によるパーキンソン病の分子機構解明 Reviewed
広常 真治
(公財)上原記念生命科学財団 上原記念生命科学財団研究報告集 31 1 - 5 2017.12
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Alpha-synuclein facilitates to form short unconventional microtubules that have a unique function in the axonal transport Reviewed
Toba Shiori, Jin Mingyue, Yamada Masami, Kumamoto Kanako, Matsumoto Sakiko, Yasunaga Takuo, Fukunaga Yuko, Miyazawa Atsuo, Fujita Sakiko, Itoh Kyoko, Fushiki Shinji, Kojima Hiroaki, Wanibuchi Hideki, Arai Yoshiyuki, Nagai Takeharu, Hirotsune Shinji
SCIENTIFIC REPORTS 7 ( 1 ) 16386 2017.11（ ISSN:2045-2322 ）
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Developmental downregulation of LIS1 expression limits axonal extension and allows axon pruning Reviewed
Kumamoto Kanako, Iguchi Tokuichi, Ishida Ryuichi, Uemura Takuya, Sato Makoto, Hirotsune Shinji
BIOLOGY OPEN 6 ( 7 ) 1041 - 1055 2017.07（ ISSN:2046-6390 ）
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Katanin p80, NuMA and cytoplasmic dynein cooperate to control microtubule dynamics Reviewed
Jin Mingyue, Pomp Oz, Shinoda Tomoyasu, Toba Shiori, Torisawa Takayuki, Furuta Ken'ya, Oiwa Kazuhiro, Yasunaga Takuo, Kitagawa Daiju, Matsumura Shigeru, Miyata Takaki, Tan Thong Teck, Reversade Bruno, Hirotsune Shinji
SCIENTIFIC REPORTS 7 39902 2017.01（ ISSN:2045-2322 ）
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Ndel1 suppresses ciliogenesis in proliferating cells by regulating the trichoplein-Aurora A pathway Reviewed
Inaba Hironori, Goto Hidemasa, Kasahara Kousuke, Kumamoto Kanako, Yonemura Shigenobu, Inoko Akihito, Yamano Shotaro, Wanibuchi Hideki, He Dongwei, Goshima Naoki, Kiyono Tohru, Hirotsune Shinji, Inagaki Masaki
JOURNAL OF CELL BIOLOGY 212 ( 4 ) 409 - 423 2016.02（ ISSN:0021-9525 ）
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Lis1 restricts the conformational changes in cytoplasmic dynein on microtubules Reviewed
Toba Shiori, Koyasako Kotaro, Yasunaga Takuo, Hirotsune Shinji
MICROSCOPY 64 ( 6 ) 419 - 427 2015.12（ ISSN:2050-5698 ）
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DBZ Regulates Cortical Cell Positioning and Neurite Development by Sustaining the Anterograde Transport of Lis1 and DISC1 through Control of Ndel1 Dual-Phosphorylation Reviewed
Okamoto Masayuki, Iguchi Tokuichi, Hattori Tsuyoshi, Matsuzaki Shinsuke, Koyama Yoshihisa, Taniguchi Manabu, Komada Munekazu, Xie Min-Jue, Yagi Hideshi, Shimizu Shoko, Konishi Yoshiyuki, Omi Minoru, Yoshimi Tomohiko, Tachibana Taro, Fujieda Shigeharu, Katayama Taiichi, Ito Akira, Hirotsune Shinji, Tohyama Masaya, Sato Makoto
JOURNAL OF NEUROSCIENCE 35 ( 7 ) 2942 - 2958 2015.02（ ISSN:0270-6474 ）
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Ndel1 suppresses unscheduled cilia formation in proliferating cells by regulating the trichoplein-Aurora-A pathway. Reviewed
Inaba H., Goto H., Kasahara K., Kumamoto K., Yonemura S., Inoko A., Yamano S., Wanibuchi H., He D., Goshima N., Kiyono T., Hirotsune S., Inagaki M.
MOLECULAR BIOLOGY OF THE CELL 26 2015（ ISSN:1059-1524 ）
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細胞質ダイニンの制御機構の解明 Reviewed
広常 真治
(公財)上原記念生命科学財団 上原記念生命科学財団研究報告集 28 1 - 6 2014.12
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Arl3 and LC8 regulate dissociation of dynactin from dynein Reviewed
Jin Mingyue, Yamada Masami, Arai Yoshiyuki, Nagai Takeharu, Hirotsune Shinji
NATURE COMMUNICATIONS 5 5295 2014.10（ ISSN:2041-1723 ）
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The Phosphatase PP4c Controls Spindle Orientation to Maintain Proliferative Symmetric Divisions in the Developing Neocortex Reviewed
Xie Yunli, Jueschke Christoph, Esk Christopher, Hirotsune Shinji, Knoblich Juergen A.
NEURON 79 ( 2 ) 254 - 265 2013.07（ ISSN:0896-6273 ）
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Rab6a releases LIS1 from a dynein idling complex and activates dynein for retrograde movement Reviewed
Yamada Masami, Kumamoto Kanako, Mikuni Shintaro, Arai Yoshiyuki, Kinjo Masataka, Nagai Takeharu, Tsukasaki Yoshikazu, Watanabe Tomonobu M., Fukui Mitsuru, Jin Mingyue, Toba Shiori, Hirotsune Shinji
NATURE COMMUNICATIONS 4 2033 2013.06（ ISSN:2041-1723 ）
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Kinesin-1 regulates dendrite microtubule polarity in Caenorhabditis elegans Reviewed
Yan Jing, Chao Dan L., Toba Shiori, Koyasako Kotaro, Yasunaga Takuo, Hirotsune Shinji, Shen Kang
ELIFE 2 e00133 2013.03（ ISSN:2050-084X ）
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Post-natal treatment by a blood-brain-barrier permeable calpain inhibitor, SNJ1945 rescued defective function in lissencephaly Reviewed
Toba Shiori, Tamura Yasuhisa, Kumamoto Kanako, Yamada Masami, Takao Keizo, Hattori Satoko, Miyakawa Tsuyoshi, Kataoka Yosky, Azuma Mitsuyoshi, Hayasaka Kiyoshi, Amamoto Masano, Tominaga Keiko, Wynshaw-Boris Anthony, Wanibuchi Hideki, Oka Yuichiro, Sato Makoto, Kato Mitsuhiro, Hirotsune Shinji
SCIENTIFIC REPORTS 3 1224 2013.02（ ISSN:2045-2322 ）
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ALLN rescues an in vitro excitatory synaptic transmission deficit in Lis1 mutant mice Reviewed
Sebe Joy Y., Bershteyn Marina, Hirotsune Shinji, Wynshaw-Boris Anthony, Baraban Scott C.
JOURNAL OF NEUROPHYSIOLOGY 109 ( 2 ) 429 - 436 2013.01（ ISSN:0022-3077 ）
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Progesterone induced mesenchymal differentiation and rescued cystic dilation of renal tubules of Pkd1(-/-) mice Reviewed
Wachi Tomoka, Yoshida Noriyuki, Funae Yoshihiko, Ueno Munehisa, Germino Gregory G., Hirotsune Shinji, Deguchi Nobuhiro
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 425 ( 2 ) 212 - 218 2012.08（ ISSN:0006-291X ）
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Activation of Aurora-A Is Essential for Neuronal Migration via Modulation of Microtubule Organization Reviewed
Takitoh Takako, Kumamoto Kanako, Wang Chen-Chi, Sato Makoto, Toba Shiori, Wynshaw-Boris Anthony, Hirotsune Shinji
JOURNAL OF NEUROSCIENCE 32 ( 32 ) 11050 - 11066 2012.08（ ISSN:0270-6474 ）
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A unique role of dynein and nud family proteins in corticogenesis Reviewed
Toba Shiori, Hirotsune Shinji
NEUROPATHOLOGY 32 ( 4 ) 432 - 439 2012.08（ ISSN:0919-6544 ）
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Trichoplein controls microtubule anchoring at the centrosome by binding to Odf2 and ninein Reviewed
Ibi Miho, Zou Peng, Inoko Akihito, Shiromizu Takashi, Matsuyama Makoto, Hayashi Yuko, Enomoto Masato, Mori Daisuke, Hirotsune Shinji, Kiyono Tohru, Tsukita Sachiko, Goto Hidemasa, Inagaki Masaki
JOURNAL OF CELL SCIENCE 124 ( 6 ) 857 - 864 2011.03（ ISSN:0021-9533 ）
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Global Developmental Gene Expression and Pathway Analysis of Normal Brain Development and Mouse Models of Human Neuronal Migration Defects Reviewed
Pramparo Tiziano, Libiger Ondrej, Jain Sonia, Li Hong, Youn Yong Ha, Hirotsune Shinji, Schork Nicholas J., Wynshaw-Boris Anthony
PLOS GENETICS 7 ( 3 ) e1001331 2011.03（ ISSN:1553-7404 ）
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Functional Dissection of LIS1 and NDEL1 Towards Understanding the Molecular Mechanisms of Cytoplasmic Dynein Regulation Reviewed
Torisawa Takayuki, Nakayama Akiko, Furuta Ken'ya, Yamada Masami, Hirotsune Shinji, Toyoshima Yoko Y.
JOURNAL OF BIOLOGICAL CHEMISTRY 286 ( 3 ) 1959 - 1965 2011.01（ ISSN:0021-9258 ）
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Lissencephaly: Mechanistic insights from animal models and potential therapeutic strategies Reviewed
Wynshaw-Boris Anthony, Pramparo Tiziano, Youn Yong Ha, Hirotsune Shinji
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY 21 ( 8 ) 823 - 830 2010.10（ ISSN:1084-9521 ）
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A novel strategy for therapeutic intervention for the genetic disease: Preventing proteolytic cleavage using small chemical compound Reviewed
Yamada Masami, Hirotsune Shinji, Wynshaw-Boris Anthony
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY 42 ( 9 ) 1401 - 1407 2010.09（ ISSN:1357-2725 ）
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Novel Embryonic Neuronal Migration and Proliferation Defects in Dcx Mutant Mice Are Exacerbated by Lis1 Reduction Reviewed
Pramparo Tiziano, Youn Yong Ha, Yingling Jessica, Hirotsune Shinji, Wynshaw-Boris Anthony
JOURNAL OF NEUROSCIENCE 30 ( 8 ) 3002 - 3012 2010.02（ ISSN:0270-6474 ）
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mNUDC is required for plus-end-directed transport of cytoplasmic dynein and dynactins by kinesin-1 Reviewed
Yamada Masami, Toba Shiori, Takitoh Takako, Yoshida Yuko, Mori Daisuke, Nakamura Takeshi, Iwane Atsuko H., Yanagida Toshio, Imai Hiroshi, Yu-Lee Li-yuan, Schroer Trina, Wynshaw-Boris Anthony, Hirotsune Shinji
EMBO JOURNAL 29 ( 3 ) 517 - 531 2010.02（ ISSN:0261-4189 ）
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The essential role of LIS1, NDEL1 and Aurora-A in polarity formation and microtubule organization during neurogensis Reviewed
Yamada Masami, Hirotsune Shinji, Wynshaw-Boris Anthony
CELL ADHESION & MIGRATION 4 ( 2 ) 180 - 184 2010（ ISSN:1933-6918 ）
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Distinct Dose-Dependent Cortical Neuronal Migration and Neurite Extension Defects in Lis1 and Ndel1 Mutant Mice Reviewed
Youn Yong Ha, Pramparo Tiziano, Hirotsune Shinji, Wynshaw-Boris Anthony
JOURNAL OF NEUROSCIENCE 29 ( 49 ) 15520 - 15530 2009.12（ ISSN:0270-6474 ）
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CRMP-2 directly binds to cytoplasmic dynein and interferes with its activity Reviewed
Arimura Nariko, Hattori Atsushi, Kimura Toshihide, Nakamuta Shinichi, Funahashi Yasuhiro, Hirotsune Shinji, Furuta Kenya, Urano Takashi, Toyoshima Yoko Y., Kaibuchi Kozo
JOURNAL OF NEUROCHEMISTRY 111 ( 2 ) 380 - 390 2009.10（ ISSN:0022-3042 ）
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Inhibition of calpain increases LIS1 expression and partially rescues in vivo phenotypes in a mouse model of lissencephaly Reviewed
Yamada Masami, Yoshida Yuko, Mori Daisuke, Takitoh Takako, Kengaku Mineko, Umeshima Hiroki, Takao Keizo, Miyakawa Tsuyoshi, Sato Makoto, Sorimachi Hiroyuki, Wynshaw-Boris Anthony, Hirotsune Shinji
NATURE MEDICINE 15 ( 10 ) 1202 - U132 2009.10（ ISSN:1078-8956 ）
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An essential role of the aPKC-Aurora A-NDEL1 pathway in neurite elongation by modulation of microtubule dynamics.
Nature Cell Biology 11 1057 - 1068 2009
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LIS1 and NDEL1 coordinate the plus-end-directed transport of cytoplasmic dynein Reviewed
Yamada Masami, Toba Shiori, Yoshida Yuko, Haratani Koji, Mori Daisuke, Yano Yoshihisa, Mimori-Kiyosue Yuko, Nakamura Takeshi, Itoh Kyoko, Fushiki Shinji, Setou Mitsutoshi, Wynshaw-Boris Anthony, Torisawa Takayuki, Toyoshima Yoko Y., Hirotsune Shinji
EMBO JOURNAL 27 ( 19 ) 2471 - 2483 2008.10（ ISSN:0261-4189 ）
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[Molecular mechanism of lissencephaly: how LIS1 regulates cytoplasmic dynein]. Reviewed
Hirotsune S
No to hattatsu = Brain and development 40 ( 3 ) 208 - 12 2008.05（ ISSN:0029-0831 ）
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[Special issue for the 49th annual meeting of the Japanese Society of Child Neurology. July 5-7, 2007 Osaka. Symposium II. Molecular mechanism of brain formation. Introductory remarks]. Reviewed
Hirotsune S, Kato M
No to hattatsu = Brain and development 40 ( 3 ) 202 - 3 2008.05（ ISSN:0029-0831 ）
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[Molecular mechanism of lissencephaly--how LIS1 and NDEL1 regulate cytoplasmic dynein?]. Reviewed
Hirotsune S
Brain and nerve = Shinkei kenkyu no shinpo 60 ( 4 ) 375 - 81 2008.04（ ISSN:1881-6096 ）
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Protein phosphatase 4 catalytic subunit regulates Cdk1 activity and microtubule organization via NDEL1 dephosphorylation. Reviewed
Toyo-oka K, Mori D, Yano Y, Shiota M, Iwao H, Goto H, Inagaki M, Hiraiwa N, Muramatsu M, Wynshaw-Boris A, Yoshiki A, Hirotsune S
The Journal of cell biology 180 ( 6 ) 1133 - 47 2008.03（ ISSN:0021-9525 ）
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Neuroepithelial stem cell proliferation requires LIS1 for precise spindle orientation and symmetric division Reviewed
Yingling Jessica, Youn Yong Ha, Darling Dawn, Toyo-Oka Kazuhito, Pramparo Tiziano, Hirotsune Shinji, Wynshaw-Boris Anthony
CELL 132 ( 3 ) 474 - 486 2008.02（ ISSN:0092-8674 ）
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LIS1 and NDEL1 coordinate the plus-end-directed transport of cytoplasmic dynein.
The EMBO journal 27 2471 - 2483 2008
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DISC1 regulates the transport of the NUDEL/LIS1/14-3-3 epsilon complex through Kinesin-1 Reviewed
Taya Shinichiro, Shinoda Tomoyasu, Tsuboi Daisuke, Asaki Junko, Nagai Kumiko, Hikita Takao, Kuroda Setsuko, Kuroda Keisuke, Shimizu Mariko, Hirotsune Shinji, Iwamatsu Akihiro, Kaibuchi Kozo
JOURNAL OF NEUROSCIENCE 27 ( 1 ) 15 - 26 2007.01（ ISSN:0270-6474 ）
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NDEL1 phosphorylation by aurora-A kinase is essential for centrosomal maturation, separation, and TACC3 recruitment Reviewed
Mori Daisuke, Yano Yoshihisa, Toyo-Oka Kazuhito, Yoshida Noriyuki, Yamada Masami, Muramatsu Masami, Zhang Dongwei, Saya Hideyuki, Toyoshima Yoko Y., Kinoshita Kazuhisa, Wynshaw-Boris Anthony, Hirotsune Shinji
MOLECULAR AND CELLULAR BIOLOGY 27 ( 1 ) 352 - 367 2007.01（ ISSN:0270-7306 ）
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LIS 1 heterozygous mutant mice show epileptic EEG pattern and lethal seizure induced by increasing-current electroshock test Reviewed
Yamashita H., Yoda H., Okajima H., Kitana Y., Takazawa A., Toyo-oka K., Hirotsune S., Maruki T., Toyoshima R., Yamauchi T.
EPILEPSIA 48 90 - 90 2007（ ISSN:0013-9580 ）
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Paradigm of dynein regulation by Lis1 towards elucidation of neuronal migration Reviewed
Hirotsune S.
JOURNAL OF NEUROCHEMISTRY 98 38 - 38 2006.07（ ISSN:0022-3042 ）
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Mnt-deficient mammary glands exhibit impaired involution and tumors with characteristics of Myc overexpression Reviewed
Toyo-oka Kazuhito, Bowen Timothy J., Hirotsune Shinji, Li Zirong, Jain Sonia, Ota Sara, Escoubet-Lozach Laure, Garcia-Bassets Ivan, Lozach Jean, Rosenfeld Michael G., Glass Christopher K., Eisenman Robert, Ren Bing, Hurlin Peter, Wynshaw-Boris Anthony
CANCER RESEARCH 66 ( 11 ) 5565 - 5573 2006.06（ ISSN:0008-5472 ）
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[Unique role of LIS1 and NDEL1 as a regulator of cytoplasmic dynein]. Reviewed
Hirotsune S
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 51 ( 6 Suppl ) 586 - 90 2006.05（ ISSN:0039-9450 ）
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Recruitment of katanin p60 by phosphorylated NDEL1, an LIS1 interacting protein, is essential for mitotic cell division and neuronal migration Reviewed
Toyo-Oka K, Sasaki S, Yano Y, Mori D, Kobayashi T, Toyoshima YY, Tokuoka SM, Ishii S, Shimizu T, Muramatsu M, Hiraiwa N, Yoshiki A, Wynshaw-Boris A, Hirotsune S
HUMAN MOLECULAR GENETICS 14 ( 21 ) 3113 - 3128 2005.11（ ISSN:0964-6906 ）
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Complete loss of Ndel1 results in neuronal migration defects and early embryonic lethality Reviewed
Sasaki S, Mori D, Toyo-oka K, Chen A, Garrett-Beal L, Muramatsu M, Miyagawa S, Hiraiwa N, Yoshiki A, Wynshaw-Boris A, Hirotsune S
MOLECULAR AND CELLULAR BIOLOGY 25 ( 17 ) 7812 - 7827 2005.09（ ISSN:0270-7306 ）
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LIS1 and NUDEL directly regulate the motility of cytoplasmic dynein in cooperative manner Reviewed
Toba S, Toyo-oka K, Hirotsune S, Toyoshima YY
BIOPHYSICAL JOURNAL 88 ( 1 ) 652A - 652A 2005.01（ ISSN:0006-3495 ）
MISC
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PKD1モデルマウスに対してプロゲステロンの与える影響について Reviewed
広常 真治
(有)科学評論社 腎臓内科・泌尿器科 1 ( 5 ) 478 - 484 2015.05（ ISSN:2188-9147 ）
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Toba Shiori, Hirotsune Shinji
John Wiley & Sons Australia, Ltd NEUROPATHOLOGY 32 ( 4 ) 432 - 439 2012.08（ ISSN:0919-6544 ）
Presentations
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微小管結合タンパク質アルファシヌクレインの神経軸索内輸送における機能解析 Domestic conference
鳥羽 栞, 金 明月, 山田 雅巳, 松本 早紀子, 安永 卓生, 福永 優子, 宮澤 淳夫, 小嶋 寛明, 新井 由之, 永井 健治, 広常 真治
Dementia Japan 2018.09 (一社)日本認知症学会
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微小管結合タンパク質アルファシヌクレインの微小管および微小管依存細胞内輸送における機能解析(Alpha-synuclein binds unconventional microtubules that have a unique function) Domestic conference
Toba Shiori, Jin Mingyue, Yamada Masami, Matsumoto Sakiko, Yasunaga Takuo, Fukunaga Yuko, Miyazawa Atsuo, Kojima Hiroaki, Arai Yoshiyuki, Nagai Takeharu, Hirotsune Shinji
生物物理 2017.08 (一社)日本生物物理学会
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電子顕微鏡トモグラフィーによって明らかになった細胞質ダイニンのモータードメインの配置(Orientation of two motor domains of cytoplasmic dynein characterized using electron computed tomography) Domestic conference
Koyasako Kotaro, Toba Shiori, Hirotsune Shinji, Yasunaga Takuo
生物物理 2016.10 (一社)日本生物物理学会
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アルファシヌクレインタンパク質による輸送性微小管の制御機構(Alpha-synuclein binds unconventional microtubules that have a unique function) Domestic conference
Toba Shiori, Jin Mingyue, Yamada Masami, Yasunaga Takuo, Fukunaga Yuko, Miyazawa Atsuo, Itoh Kyoko, Fushiki Shinji, Kojima Hiroaki, Wanibuchi Hideki, Arai Yoshiyuki, Nagai Takeharu, Hirotsune Shinji
生物物理 2016.10 (一社)日本生物物理学会
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α-synucleinは固有機能を有する非定型微小管と結合する(Alpha-synuclein binds unconventional microtubules that have a unique function) Domestic conference
鳥羽 栞, 金 明月, 山田 雅巳, 安永 卓生, 福永 優子, 宮澤 淳夫, 小嶋 寛明, 新井 由之, 永井 健治, 広常 真治
Dementia Japan 2016.10 (一社)日本認知症学会
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Ndel1はtrichoplein-Aurora A経路の制御によって増殖細胞の線毛形成を抑制する Domestic conference
稲葉 弘哲, 後藤 英仁, 笠原 広介, 熊本 香奈子, 米村 重信, 猪子 誠人, 何 東偉, 五島 直樹, 山野 荘太郎, 鰐渕 英機, 清野 透, 広常 真治, 稲垣 昌樹
日本癌学会総会記事 2016.10 日本癌学会
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細胞骨格、形態、運動を制御する分子機構 Ndel1は増殖細胞において一次線毛形成を抑制する Domestic conference
稲葉 弘哲, 後藤 英仁, 笠原 広介, 熊本 香奈子, 米村 重信, 猪子 誠人, 何 東偉, 五島 直樹, 山野 荘太郎, 鰐渕 英機, 清野 透, 広常 真治, 稲垣 昌樹
日本細胞生物学会大会講演要旨集 2016.05 (一社)日本細胞生物学会
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Cargo unloadingに関する調節機序 Arl3とLC8は協調的にdynein-dynactin解離を誘導する(A regulatory mechanism of cargo unloading: Arl3 and LC8 coordinately induce dissociation of the dynein-dynactin) Domestic conference
Yamada Masami, Jin Mingyue, Hirotsune Shinji
日本細胞生物学会大会講演要旨集 2015.06 (一社)日本細胞生物学会
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Ndel1による一次線毛形成抑制は腎臓の形態形成に重要である Domestic conference
稲葉 弘哲, 後藤 英仁, 笠原 広介, 猪子 誠人, 熊本 香奈子, 米村 重信, 何 東偉, 五島 直樹, 山野 荘太郎, 鰐淵 英樹, 清野 透, 広常 真治, 稲垣 昌樹
日本細胞生物学会大会講演要旨集 2015.06 (一社)日本細胞生物学会
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Toba Shiori, Koyasako Kotaro, Yamada Masami, Yasunaga Takuo, Kojima Hiroaki, Wanibuchi Hideki, Hirotsune Shinji
生物物理 2014.08 (一社)日本生物物理学会
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Ndel1の欠損は一次線毛形成を引き起こし、細胞増殖を阻害する Domestic conference
稲葉 弘哲, 後藤 英仁, 猪子 誠人, 何 東偉, 五島 直樹, 山野 荘太郎, 鰐淵 英樹, 熊本 香奈子, 広常 真治, 清野 透, 稲垣 昌樹
日本細胞生物学会大会講演要旨集 2014.05 (一社)日本細胞生物学会
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タンパク質分解酵素カルパインの阻害薬は滑脳症モデル(LIS1ヘテロ欠損マウス)においてその症状を改善した Domestic conference
山田 雅巳, 瀧藤 尊子, 広常 真治
日本生化学会大会プログラム・講演要旨集 2011.09 (公社)日本生化学会
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皮質発生における運動蛋白およびその仲間の独特の役割 細胞質dyneinおよびnudファミリー蛋白の状況(A unique role of motor proteins and their friends in corticogenesis: landscape of cytoplasmic dynein and nud family proteins) Domestic conference
Hirotsune S
NEUROPATHOLOGY 2011.06 John Wiley & Sons Australia, Ltd
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Hirotsune Shinji
日本細胞生物学会大会講演要旨集 2011.05 (一社)日本細胞生物学会
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山田 雅巳, 瀧藤 尊子, 広常 真治
日本細胞生物学会大会講演要旨集 2011.05 (一社)日本細胞生物学会
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タンパク質分解酵素カルパインの阻害薬は滑脳症モデル(LIS1ヘテロ欠損)マウスにおいてその症状を改善した Domestic conference
山田 雅巳, 吉田 祐子, 森 大輔, 瀧藤 尊子, 見学 美根子, 梅嶋 宏樹, 高雄 啓三, 宮川 剛, 佐藤 真, 反町 洋之, Wynshaw-Boris Anthony, 広常 真治
大阪市医学会雑誌 2010.12 大阪市医学会
Grant-in-Aid for Scientific Research
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非定型微小管の構造と機能
Grant-in-Aid for Scientific Research(B) 2017.04
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神経発生、ネットワーク形成に果たす中心体の役割の解明
中心体・シリア 2013.04
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滑脳症治療への挑戦：カルパインによるリスワン分解機構の解明
Grant-in-Aid for Scientific Research on Priority Areas 2010.04
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分化と増殖のスイッチング：分裂期キナーゼの神経細胞における役割。
Grant-in-Aid for Scientific Research on Priority Areas 2009.04
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中枢神経系の形態形成と機能における細胞内物質輸送機構の解明。
Grant-in-Aid for Scientific Research(B) 2009.04
Contract research
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アルファシヌクレインの変異によるパーキンソン病発症メカニズムの解明。
AMED 2018.04
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カルパイン阻害剤を用いた滑脳症治療への新戦略。
文部科学省・経済産業省 2010.04
Outline of education staff
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生化学、細胞生物学
Charge of on-campus class subject
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Practice of biochemistry
2019 Graduate school
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Medical Research
2019 Graduate school
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Advanced Course of Medical Research
2019 Graduate school
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Exercise in Presentation
2019 Graduate school
-
Biochemistry 4
2019 Graduate school
-
Biochemistry 3
2019 Graduate school
-
Biochemistry 2
2019 Graduate school
-
Biochemistry 1
2019 Graduate school
-
Molecular Medicine
2019 Graduate school
-
Basic Course of Molecular Medicine
2019 Graduate school
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生化学実習
2019 Undergraduate
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Cell Biology
2019 Undergraduate
-
Biochemistry
2019 Undergraduate
-
Practice of biochemistry
2018 Graduate school
-
Medical Research
2018 Graduate school
-
Advanced Course of Medical Research
2018 Graduate school
-
Exercise in Presentation
2018 Graduate school
-
Biochemistry 4
2018 Graduate school
-
Biochemistry 3
2018 Graduate school
-
Biochemistry 2
2018 Graduate school
-
Biochemistry 1
2018 Graduate school
-
Molecular Medicine
2018 Graduate school
-
Basic Course of Molecular Medicine
2018 Graduate school
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生化学実習
2018 Undergraduate
-
Cell Biology
2018 Undergraduate
-
Biochemistry
2018 Undergraduate
-
Practice of biochemistry
2017 Graduate school
-
Medical Research
2017 Graduate school
-
Advanced Course of Medical Research
2017 Graduate school
-
Exercise in Presentation
2017 Graduate school
-
Biochemistry 4
2017 Graduate school
-
Biochemistry 3
2017 Graduate school
-
Biochemistry 2
2017 Graduate school
-
Biochemistry 1
2017 Graduate school
-
Molecular Medicine
2017 Graduate school
-
Basic Course of Molecular Medicine
2017 Graduate school
-
生化学実習
2017 Undergraduate
-
Cell Biology
2017 Undergraduate
-
Biochemistry
2017 Undergraduate
-
Practice of biochemistry
2016 Graduate school
-
Medical Research
2016 Graduate school
-
Advanced Course of Medical Research
2016 Graduate school
-
Exercise in Presentation
2016 Graduate school
-
Biochemistry 4
2016 Graduate school
-
Biochemistry 3
2016 Graduate school
-
Biochemistry 2
2016 Graduate school
-
Biochemistry 1
2016 Graduate school
-
Molecular Medicine
2016 Graduate school
-
Basic Course of Molecular Medicine
2016 Graduate school
-
生化学実習
2016 Undergraduate
-
Cell Biology
2016 Undergraduate
-
Biochemistry
2016 Undergraduate
-
Practice of biochemistry
2015 Graduate school
-
Medical Research
2015 Graduate school
-
Advanced Course of Medical Research
2015 Graduate school
-
Exercise in Presentation
2015 Graduate school
-
Biochemistry 4
2015 Graduate school
-
Biochemistry 3
2015 Graduate school
-
Biochemistry 2
2015 Graduate school
-
Biochemistry 1
2015 Graduate school
-
Molecular Medicine
2015 Graduate school
-
Basic Course of Molecular Medicine
2015 Graduate school
-
生化学実習
2015 Undergraduate
-
Cell Biology
2015 Undergraduate
-
Biochemistry
2015 Undergraduate
-
Practice of biochemistry
2014 Graduate school
-
Medical Research
2014 Graduate school
-
Advanced Course of Medical Research
2014 Graduate school
-
Exercise in Presentation
2014 Graduate school
-
Biochemistry 4
2014 Graduate school
-
Biochemistry 3
2014 Graduate school
-
Biochemistry 2
2014 Graduate school
-
Biochemistry 1
2014 Graduate school
-
Molecular Medicine
2014 Graduate school
-
Basic Course of Molecular Medicine
2014 Graduate school
-
生化学実習
2014 Undergraduate
-
Cell Biology
2014 Undergraduate
-
Biochemistry
2014 Undergraduate
-
Practice of biochemistry
2013 Graduate school
-
Medical Research
2013 Graduate school
-
Advanced Course of Medical Research
2013 Graduate school
-
Exercise in Presentation
2013 Graduate school
-
Biochemistry 4
2013 Graduate school
-
Biochemistry 3
2013 Graduate school
-
Biochemistry 2
2013 Graduate school
-
Biochemistry 1
2013 Graduate school
-
Molecular Medicine
2013 Graduate school
-
Basic Course of Molecular Medicine
2013 Graduate school
-
生化学実習
2013 Undergraduate
-
Cell Biology
2013 Undergraduate
-
Biochemistry
2013 Undergraduate
-
Biochemistry
2012 Undergraduate
-
Practice of biochemistry
2012 Graduate school
-
Medical Research
2012 Graduate school
-
Advanced Course of Medical Research
2012 Graduate school
-
Exercise in Presentation
2012 Graduate school
-
Biochemistry 4
2012 Graduate school
-
Biochemistry 3
2012 Graduate school
-
Biochemistry 2
2012 Graduate school
-
Biochemistry 1
2012 Graduate school
-
Molecular Medicine
2012 Graduate school
-
Basic Course of Molecular Medicine
2012 Graduate school
-
生化学実習
2012 Undergraduate
-
Cell Biology
2012 Undergraduate
-
Biochemistry
2011 Undergraduate
-
Practice of biochemistry
2011 Graduate school
-
Medical Research
2011 Graduate school
-
Advanced Course of Medical Research
2011 Graduate school
-
Exercise in Presentation
2011 Graduate school
-
Biochemistry 4
2011 Graduate school
-
Biochemistry 3
2011 Graduate school
-
Biochemistry 2
2011 Graduate school
-
Biochemistry 1
2011 Graduate school
-
Molecular Medicine
2011 Graduate school
-
Basic Course of Molecular Medicine
2011 Graduate school
-
生化学実習
2011 Undergraduate
-
Cell Biology
2011 Undergraduate
-
Biochemistry
2010 Undergraduate
-
Practice of biochemistry
2010 Graduate school
-
Medical Research
2010 Graduate school
-
Advanced Course of Medical Research
2010 Graduate school
-
Exercise in Presentation
2010 Graduate school
-
Biochemistry 4
2010 Graduate school
-
Biochemistry 3
2010 Graduate school
-
Biochemistry 1
2010 Graduate school
-
Biochemistry 1
2010 Graduate school
-
Molecular Medicine
2010 Graduate school
-
Basic Course of Molecular Medicine
2010 Graduate school
-
生化学実習
2010 Undergraduate
-
Cell Biology
2010 Undergraduate
Charge of off-campus class subject
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生理学
Faculty development activities
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FD活動への貢献 2010
Social Activities
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電子顕微鏡を用いた神経細胞の観察
Role(s)： Planner, Logistic support
大阪市立大学 大阪市立大学・大学院医学研究科 2018.08
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電子顕微鏡を用いた神経細胞の観察
Role(s)： Planner, Logistic support, Performer
大阪市立大学 大阪市立大学・大学院医学研究科 2018.08
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脳のしくみ
Role(s)： Lecturer
大阪市立大学・大学院医学研究科 2018.07
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第173回市民医学講座
Role(s)： Lecturer
阿倍野メディックス 2013.06
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市民医学講座「ゲノム研究の最先端：病気の原因探索と治療への応用」
Role(s)： Lecturer
医学部附属病院 2013.06
Visiting Lectures ⇒ Link to the list of Visiting Lectures
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脳の発生と疾患
Category：Modern system science (knowledge information system, environmental system, educational welfare, psychology), Commerce (management, public management), Economics, Law (law, politics, administration), Literature (literature, philosophy, history, art, human behavior, language, culture, society / gender), Science (mathematics, physics, chemistry, biology, geology, biochemistry), Engineering (machinery, electronics / physics, electrical / electronics, electrical information, chemical biotechnology, architecture, cities (civil engineering / environment), material chemistry, aerospace, marine systems, applied chemistry, chemistry, materials), Life sciences (food, nutrition science, living environment, human welfare), Agricultural science (applied biology, biofunctional chemistry, green space environmental science), Medicine (medical care, rehabilitation, health exercise science, physical fitness / training, sports practice science), Nursing (nursing, sex education), Veterinary
Other
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Job Career
1987.04 - 1989.03