Stress can attenuate hepatic lipid accumulation via elevation of hepatic β-muricholic acid levels in mice with nonalcoholic steatohepatitis Reviewed International coauthorship

Takada S, Matsubara T, Fujii H, Sato-Matsubara M, Daikoku A, Odagiri N, Amano-Teranishi Y, Kawada N, Ikeda K.

Laboratory Investigation   101 ( 2 )   193 - 203   2021.02

TGF-β1-driven reduction of cytoglobin leads to oxidative DNA damage in stellate cells during non-alcoholic steatohepatitis Reviewed International coauthorship

Okina Y, Sato-Matsubara M, Matsubara T, Daikoku A, Longato L, Rombouts K, Thanh Thuy LT, Ichikawa H, Minamiyama Y, Kadota M, Fujii H, Enomoto M, Ikeda K, Yoshizato K, Pinzani M, Kawada N.

Journal of Hepatology   73 ( 4 )   882 - 895   2020.10

Involvement of ERK1/2 activation in the gene expression of senescence-associated secretory factors in human hepatic stellate cells. Reviewed International coauthorship

Odagiri N, Matsubara T, Higuchi M, Takada S, Urushima H, Sato-Matsubara M, Teranishi Y, Yoshizato K, Kawada N, Ikeda K

Molecular and cellular biochemistry   455   7 - 19   2019.05（ ISSN:0300-8177 ）

XPA expression is a predictive marker of the effectiveness of neoadjuvant chemotherapy for locally advanced uterine cervical cancer. Reviewed

Wada T, Fukuda T, Shimomura M, Inoue Y, Kawanishi M, Tasaka R, Yasui T, Ikeda K, Sumi T

Oncology letters   15 ( 3 )   3766 - 3771   2018.03（ ISSN:1792-1074 ）

Fibroblast growth factor 2 (FGF2) regulates cytoglobin expression and activation of human hepatic stellate cells via JNK signaling Reviewed

Sato-Matsubara Misako, Matsubara Tsutomu, Daikoku Atsuko, Okina Yoshinori, Longato Lisa, Rombouts Krista, Le Thi Thanh Thuy, Adachi Jun, Tomonaga Takeshi, Ikeda Kazuo, Yoshizato Katsutoshi, Pinzani Massimo, Kawada Norifumi

JOURNAL OF BIOLOGICAL CHEMISTRY   292 ( 46 )   18961 - 18972   2017.11（ ISSN:0021-9258 ）

Comprehensive analysis of transcriptome and metabolome analysis in Intrahepatic Cholangiocarcinoma and Hepatocellular Carcinoma Reviewed

Murakami Yoshiki, Kubo Shoji, Tamori Akihiro, Itami Saori, Kawamura Etsushi, Iwaisako Keiko, Ikeda Kazuo, Kawada Norifumi, Ochiya Takahiro, Taguchi Y-H

SCIENTIFIC REPORTS   5   16294   2015.11（ ISSN:2045-2322 ）

Involvement of hepatic stellate cell cytoglobin in acute hepatocyte damage through the regulation of CYP2E1-mediated xenobiotic metabolism Reviewed

Teranishi Yuga, Matsubara Tsutomu, Krausz Kristopher W., Le Thi T. T., Gonzalez Frank J., Yoshizato Katsutoshi, Ikeda Kazuo, Kawada Norifumi

LABORATORY INVESTIGATION   95 ( 5 )   515 - 524   2015.05（ ISSN:0023-6837 ）

Deletion of the Collagen-specific Molecular Chaperone Hsp47 Causes Endoplasmic Reticulum Stress-mediated Apoptosis of Hepatic Stellate Cells Reviewed

Kawasaki Kunito, Ushioda Ryo, Ito Shinya, Ikeda Kazuo, Masago Yusaku, Nagata Kazuhiro

JOURNAL OF BIOLOGICAL CHEMISTRY   290 ( 6 )   3639 - 3646   2015.02（ ISSN:0021-9258 ）

Efficient Engraftment of Human Induced Pluripotent Stem Cell-Derived Hepatocyte-Like Cells in uPA/SCID Mice by Overexpression of FNK, a Bcl-xL Mutant Gene Reviewed

Nagamoto Yasuhito, Takayama Kazuo, Tashiro Katsuhisa, Tateno Chise, Sakurai Fuminori, Tachibana Masashi, Kawabata Kenji, Ikeda Kazuo, Tanaka Yasuhito, Mizuguchi Hiroyuki

CELL TRANSPLANTATION   24 ( 6 )   1127 - 1138   2015（ ISSN:0963-6897 ）

Cilostazol attenuates hepatic stellate cell activation and protects mice against carbon tetrachloride-induced liver fibrosis Reviewed

Saito Shunichi, Hata Koichiro, Iwaisako Keiko, Yanagida Atsuko, Takeiri Masatoshi, Tanaka Hirokazu, Kageyama Shoichi, Hirao Hirofumi, Ikeda Kazuo, Asagiri Masataka, Uemoto Shinji

HEPATOLOGY RESEARCH   44 ( 4 )   460 - 473   2014.04（ ISSN:1386-6346 ）

シロスタゾールは肝星細胞の活性化を抑制して四塩化炭素に誘発される肝線維症からマウスを保護する(Cilostazol attenuates hepatic stellate cell activation and protects mice against carbon tetrachloride-induced liver fibrosis)

Saito Shunichi, Hata Koichiro, Iwaisako Keiko, Yanagida Atsuko, Takeiri Masatoshi, Tanaka Hirokazu, Kageyama Shoichi, Hirao Hirofumi, Ikeda Kazuo, Asagiri Masataka, Uemoto Shinji

Hepatology Research   44 ( 4 )   460 - 473   2014.04（ ISSN:1386-6346 ）

TGF-beta-SMAD3 signaling mediates hepatic bile acid and phospholipid metabolism following lithocholic acid-induced liver injury Reviewed

Matsubara Tsutomu, Tanaka Naoki, Sato Misako, Kang Dong Wook, Krausz Kristopher W., Flanders Kathleen C., Ikeda Kazuo, Luecke Hans, Wakefield Lalage M., Gonzalez Frank J.

JOURNAL OF LIPID RESEARCH   53 ( 12 )   2698 - 2707   2012.12（ ISSN:0022-2275 ）

MicroRNA-221/222 upregulation indicates the activation of stellate cells and the progression of liver fibrosis Reviewed

Ogawa Tomohiro, Enomoto Masaru, Fujii Hideki, Sekiya Yumiko, Yoshizato Katsutoshi, Ikeda Kazuo, Kawada Norifumi

GUT   61 ( 11 )   1600 - 1609   2012.11（ ISSN:0017-5749 ）

Induction of microRNA-214-5p in human and rodent liver fibrosis. Reviewed

Iizuka M, Ogawa T, Enomoto M, Motoyama H, Yoshizato K, Ikeda K, Kawada N

Fibrogenesis & tissue repair   5 ( 1 )   12   2012.08

Down-Regulation of Cyclin E1 Expression by MicroRNA-195 Accounts for Interferon-beta-Induced Inhibition of Hepatic Stellate Cell Proliferation Reviewed

Sekiya Yumiko, Ogawa Tomohiro, Iizuka Masashi, Yoshizato Katsutoshi, Ikeda Kazuo, Kawada Norifumi

JOURNAL OF CELLULAR PHYSIOLOGY   226 ( 10 )   2535 - 2542   2011.10（ ISSN:0021-9541 ）

Suppression of hepatic stellate cell activation by microRNA-29b Reviewed

Sekiya Yumiko, Ogawa Tomohiro, Yoshizato Katsutoshi, Ikeda Kazuo, Kawada Norifumi

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   412 ( 1 )   74 - 79   2011.08（ ISSN:0006-291X ）

Promotion of Liver and Lung Tumorigenesis in DEN-Treated Cytoglobin-Deficient Mice Reviewed

Le Thi Thanh Thuy, Morita Takashi, Yoshida Kayo, Wakasa Kenichi, Iizuka Masashi, Ogawa Tomohiro, Mori Mami, Sekiya Yumiko, Momen Shinobu, Motoyama Hiroyuki, Ikeda Kazuo, Yoshizato Katsutoshi, Kawada Norifumi

AMERICAN JOURNAL OF PATHOLOGY   179 ( 2 )   1050 - 1060   2011.08（ ISSN:0002-9440 ）

Pitavastatin inhibits hepatic steatosis and fibrosis in non-alcoholic steatohepatitis model rats. Reviewed International coauthorship

Miyaki T, Nojiri S, Shinkai N, Kusakabe A, Matsuura K, Iio E, Takahashi S, Yan G, Ikeda K, Joh T

Hepatology research   41 ( 4 )   375 - 85   2011.04（ ISSN:1386-6346 ）

ピタバスタチンは非アルコール性脂肪肝ラットモデル肝臓の脂肪変性および線維形成を抑制する(Pitavastatin inhibits hepatic steatosis and fibrosis in non-alcoholic steatohepatitis model rats)

Miyaki Tomokatsu, Nojiri Shunsuke, Shinkai Noboru, Kusakabe Atsunori, Matsuura Kentaro, Iio Etsuko, Takahashi Satoru, Yan Ge, Ikeda Kazuo, Joh Takashi

Hepatology Research   41 ( 4 )   375 - 385   2011.04（ ISSN:1386-6346 ）

Dynamic Relationship of Focal Contacts and Hemidesmosome Protein Complexes in Live Cells Reviewed

Ozawa Toshiyuki, Tsuruta Daisuke, Jones Jonathan C. R., Ishii Masamitsu, Ikeda Kazuo, Harada Teruichi, Aoyama Yumi, Kawada Akira, Kobayashi Hiromi

JOURNAL OF INVESTIGATIVE DERMATOLOGY   130 ( 6 )   1624 - 1635   2010.06（ ISSN:0022-202X ）

Laminin-511, inducer of hair growth, is down-regulated and its suppressor in hair growth, laminin-332 up-regulated in chemotherapy-induced alopecia Reviewed

IMANISHI Hisayoshi, TSURUTA Daisuke, TATEISHI Chiharu, SUGAWARA Koji, PAUS Ralf, TSUJI Tsutomu, ISHII Masamitsu, IKEDA Kazuo, KUNIMOTO Hiroyuki, NAKAJIMA Koichi, JONES Jonathan C. R., KOBAYASHI Hiromi

Journal of dermatological science   58 ( 1 )   43 - 54   2010.04（ ISSN:09231811 ）

化学療法による脱毛において、毛髪成長誘導因子であるラミニン-511はダウンレギュレートされ、毛髪成長抑制因子であるラミニン-332はアップレギュレートされる(Laminin-511, inducer of hair growth, is down-regulated and its suppressor in hair growth, laminin-332 up-regulated in chemotherapy-induced alopecia)

Imanishi Hisayoshi, Tsuruta Daisuke, Tateishi Chiharu, Sugawara Koji, Paus Ralf, Tsuji Tsutomu, Ishii Masamitsu, Ikeda Kazuo, Kunimoto Hiroyuki, Nakajima Koichi, Jones Jonathan C.R., Kobayashi Hiromi

Journal of Dermatological Science   58 ( 1 )   43 - 54   2010.04（ ISSN:0923-1811 ）

Suppression of type I collagen production by microRNA-29b in cultured human stellate cells Reviewed

Ogawa Tomohiro, Iizuka Masashi, Sekiya Yumiko, Yoshizato Katsutoshi, Ikeda Kazuo, Kawada Norifumi

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   391 ( 1 )   316 - 321   2010.01（ ISSN:0006-291X ）

Negligible contribution of bone marrow-derived cells to collagen production during hepatic fibrogenesis in mice. Reviewed

Higashiyama R, Moro T, Nakao S, Mikami K, Fukumitsu H, Ueda Y, Ikeda K, Adachi E, Bou-Gharios G, Okazaki I, Inagaki Y

Gastroenterology   137 ( 4 )   1459 - 66.e1   2009.10（ ISSN:0016-5085 ）

Effect of natural interferon alpha on proliferation and apoptosis of hepatic stellate cells Reviewed

Ogawa Tomohiro, Kawada Norifumi, Ikeda Kazuo

HEPATOLOGY INTERNATIONAL   3 ( 3 )   497 - 503   2009.09（ ISSN:1936-0533 ）

Impaired cutaneous wound healing with excess granulation tissue formation in TNFalpha-null mice. Reviewed

Shinozaki M, Okada Y, Kitano A, Ikeda K, Saika S, Shinozaki M

Archives of dermatological research   301 ( 7 )   531 - 7   2009.08（ ISSN:0340-3696 ）

TGF beta in fibroproliferative diseases in the eye. Reviewed

Saika S, Yamanaka O, Okada Y, Tanaka S, Miyamoto T, Sumioka T, Kitano A, Shirai K, Ikeda K

Frontiers in bioscience (Scholar edition)   1   376 - 90   2009.06（ ISSN:1945-0516 ）

Induction of tropomyosin during hepatic stellate cell activation and the progression of liver fibrosis Reviewed

Otogawa Kohji, Ogawa Tomohiro, Shiga Ryoko, Ikeda Kazuo, Kawada Norifumi

HEPATOLOGY INTERNATIONAL   3 ( 2 )   378 - 383   2009.06（ ISSN:1936-0533 ）

Suppression of Injury-Induced Conjunctiva Scarring by Peroxisome Proliferator-Activated Receptor gamma Gene Transfer in Mice Reviewed

Yamanaka Osamu, Miyazaki Ken-ichi, Kitano Ai, Saika Shizuya, Nakajima Yuji, Ikeda Kazuo

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE   50 ( 1 )   187 - 193   2009.01（ ISSN:0146-0404 ）

Inhibitory effect of blocking TGF-beta/Smad signal on injury-induced fibrosis of corneal endothelium Reviewed

Sumioka Takayoshi, Ikeda Kazuo, Okada Yuka, Yamanaka Osamu, Kitano Ai, Saika Shizuya

MOLECULAR VISION   14 ( 263-65 )   2272 - 2281   2008.12（ ISSN:1090-0535 ）

S2-03 肝線維化機構の分子形態学的解析 : 組織化学的検討を中心に(線維化機構の分子形態的解析,シンポジウム,「出島」游學-形態通詞の未来展開-,第49回日本組織細胞化学会総会・学術集会)

仲谷和記, 小川智弘, 河田則文, 池田一雄, 中島裕司

日本組織細胞化学会総会プログラムおよび抄録集   42   2008.10

ROCK1 expression is regulated by TGF beta 3 and ALK2 during valvuloseptal endocardial cushion formation Reviewed

Sakabe Masahide, Sakata Hirokazu, Matsui Hiroko, Ikeda Kazuo, Yamagishi Toshiyuki, Nakajima Yuji

ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY   291 ( 7 )   845 - 857   2008.07（ ISSN:1932-8486 ）

Induction of initial heart α-actin, smooth muscle α-actin, in chick pregastrula epiblast : The role of hypoblast and fibroblast growth factor-8 Reviewed

Matsui Hiroko, Sakabe Masahide, Sakata Hirokazu, YANAGAWA Nariaki, IKEDA Kazuo, YAMAGISHI Toshiyuki, NAKAJIMA Yuji

Japanese Society of Developmental Biologists　Development, growth & differentiation   50 ( 3 )   143 - 157   2008.04（ ISSN:00121592 ）

Corneal wound healing in an osteopontin-deficient mouse Reviewed

Miyazaki Ken-ichi, Okada Yuka, Yamanaka Osamu, Kitano Ai, Ikeda Kazuo, Kon Shigeyuki, Uede Toshimitsu, Rittling Susan R., Denhardt David T., Kao Winston Whei-Yang, Saika Shizuya

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE   49 ( 4 )   1367 - 1375   2008.04（ ISSN:0146-0404 ）

Epithelial-mesenchymal transition as a therapeutic target for prevention of ocular tissue fibrosis. Reviewed

Saika S, Yamanaka O, Flanders KC, Okada Y, Miyamoto T, Sumioka T, Shirai K, Kitano A, Miyazaki K, Tanaka S, Ikeda K

Endocrine, metabolic & immune disorders drug targets   8 ( 1 )   69 - 76   2008.03（ ISSN:1871-5303 ）

Fibrotic disorders in the eye: Targets of gene therapy Reviewed

Saika Shizuya, Yamanaka Osamu, Sumioka Takayoshi, Miyamoto Takeshi, Miyazaki Ken-Ichi, Okada Yuka, Kitano Ai, Shirai Kumi, Tanaka Sai-ichi, Ikeda Kazuo

PROGRESS IN RETINAL AND EYE RESEARCH   27 ( 2 )   177 - 196   2008.03（ ISSN:1350-9462 ）

Induction of initial heart alpha-actin, smooth muscle alpha-actin, in chick pregastrula epiblast: the role of hypoblast and fibroblast growth factor-8.

Matsui H, Sakabe M, Sakata H, Yanagawa N, Ikeda K, Yamagishi T, Nakajima Y

Development, growth & differentiation   50 ( 3 )   143 - 57   2008.03（ ISSN:0012-1592 ）

Attenuation of acute and chronic liver injury in rats by iron-deficient diet Reviewed

Otogawa Kohji, Ogawa Tomohiro, Shiga Ryoko, Nakatani Kazuki, Ikeda Kazuo, Nakajima Yuji, Kawada Norifumi

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY   294 ( 2 )   R311 - R320   2008.02（ ISSN:0363-6119 ）

Connective tissue growth factor modulates extracellular matrix production in human subconjunctival fibroblasts and their proliferation and migration in vitro Reviewed

Yamanaka Osamu, Saika Shizuya, Ikeda Kazuo, Miyazaki Ken-Ichi, Kitano Ai, Ohnishi Yoshitaka

JAPANESE JOURNAL OF OPHTHALMOLOGY   52 ( 1 )   8 - 15   2008.02（ ISSN:0021-5155 ）

Tetrandrine suppresses activation of human subconjunctival fibroblasts in vitro Reviewed

Kitano Ai, Yamanaka Osamu, Ikeda Kazuo, Ishida-Nishikawa Iku, Okada Yuka, Shirai Kumi, Saika Shizuya

CURRENT EYE RESEARCH   33 ( 7 )   559 - 565   2008（ ISSN:0271-3683 ）

Inhibitory effect of blocking TGF-beta/Smad signal on injury-induced fibrosis of corneal endothelium. Reviewed

Sumioka T, Ikeda K, Okada Y, Yamanaka O, Kitano A, Saika S

Molecular vision   14   2272 - 81   2008

Emodin suppression of ocular surface inflammatory reaction Reviewed

Kitano Ai, Saika Shizuya, Yamanaka Osamu, Ikeda Kazuo, Okada Yuka, Shirai Kumi, Reinach Peter S.

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE   48 ( 11 )   5013 - 5022   2007.11（ ISSN:0146-0404 ）

Inhibition of p38MAP kinase suppresses fibrogenic reaction in conjunctiva in mice Reviewed

Yamanaka Osamu, Saika Shizuya, Ohnishi Yoshitaka, Kim-Mitsuyama Shokei, Kamaraju Anil K., Ikeda Kazuo

MOLECULAR VISION   13 ( 190-93 )   1730 - 1739   2007.09（ ISSN:1090-0535 ）

TNF alpha suppression of corneal epithelium migration Reviewed

Okada Yuka, Ikeda Kazuo, Yamanaka Osamu, Miyamoto Takeshi, Kitano Ai, Kao Winston W. -Y., Saika Shizuya

MOLECULAR VISION   13 ( 157 )   1428 - 1435   2007.08（ ISSN:1090-0535 ）

Effect of overexpression of ppar gamma on the healing process of corneal alkali burn in mice Reviewed

Saika Shizuya, Yamanaka Osamu, Okada Yuka, Miyamoto Takeshi, Kitano Ai, Flanders Kathleen C., Ohnishi Yoshitaka, Nakajima Yuji, Kao Winston W. -Y., Ikeda Kazuo

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY   293 ( 1 )   C75 - C86   2007.07（ ISSN:0363-6143 ）

Endogenous TNF alpha suppression of neovascularization in corneal stroma in mice Reviewed

Fujita Shuko, Saika Shizuya, Kao Winston Whei-Yang, Fujita Kyoko, Miyamoto Takeshi, Ikeda Kazuo, Nakajima Yuji, Ohnishi Yoshitaka

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE   48 ( 7 )   3051 - 3055   2007.07（ ISSN:0146-0404 ）

Adenovirus-mediated expression of BMP-7 suppresses the development of liver fibrosis in rats Reviewed

Kinoshita Kohji, Iimuro Yuji, Otogawa Kohji, Saika Shizuya, Inagaki Yutaka, Nakajima Yuji, Kawada Norifumi, Fujimoto Jiro, Friedman Scott L., Ikeda Kazuo

GUT   56 ( 5 )   706 - 714   2007.05（ ISSN:0017-5749 ）

Effect of Smad7 gene overexpression on transforming growth factor beta-induced retinal pigment fibrosis in a proliferative vitreoretinopathy mouse model. Reviewed

Saika S, Yamanaka O, Nishikawa-Ishida I, Kitano A, Flanders KC, Okada Y, Ohnishi Y, Nakajima Y, Ikeda K

Archives of ophthalmology (Chicago, Ill. : 1960)   125 ( 5 )   647 - 54   2007.05（ ISSN:0003-9950 ）

Expression of large tenascin-C splice variants by hepatic stellate cells/myofibroblasts in chronic hepatitis C Reviewed

El-Karef Amro, Kaito Masahiko, Tanaka Hideaki, Ikeda Kazuo, Nishioka Tomohiro, Fujita Naoki, Inada Hiroyasu, Adachi Yukihiko, Kawada Norifumi, Nakajima Yuji, Imanaka-Yoshida Kyoko, Yoshida Toshimichi

JOURNAL OF HEPATOLOGY   46 ( 4 )   664 - 673   2007.04（ ISSN:0168-8278 ）

Erythrophagocytosis by liver macrophages (Kupffer cells) promotes oxidative stress, inflammation, and fibrosis in a rabbit model of steatohepatitis - Implications for the pathogenesis of human nonalcoholic steatohepatitis Reviewed

Otogawa Kohji, Kinoshita Kohji, Fujii Hideki, Sakabe Masahide, Shiga Ryoko, Nakatani Kazuki, Ikeda Kazuo, Nakajima Yuji, Ikura Yoshihiro, Ueda Makiko, Arakawa Tetsuo, Hato Fumihiko, Kawada Norifumi

AMERICAN JOURNAL OF PATHOLOGY   170 ( 3 )   967 - 980   2007.03（ ISSN:0002-9440 ）

Targeted and regulable expression of transgenes in hepatic stellate cells and myofibroblasts in culture and in vivo using an adenoviral Cre/IoxP system to antagonise hepatic fibrosis Reviewed

Kinoshita Kohji, Iimuro Yuji, Fujimoto Jiro, Inagaki Yutaka, Namikawa Kazuhiko, Kiyama Hiroshi, Nakajima Yuji, Otogawa Kohji, Kawada Norifumi, Friedman Scott L., Ikeda Kazuo

GUT   56 ( 3 )   396 - 404   2007.03（ ISSN:0017-5749 ）

Rho kinase inhibitor Y27632 affects initial heart myofibrillogenesis in cultured chick blastoderm Reviewed

Sakata Hirokazu, Sakabe Masahide, Matsui Hiroko, Kawada Norifumi, Nakatani Kazuki, Ikeda Kazuo, Yamagishi Toshiyuki, Nakajima Yuji

DEVELOPMENTAL DYNAMICS   236 ( 2 )   461 - 472   2007.02（ ISSN:1058-8388 ）

Spatial and temporal control of laminin-332 (5) and -511 (10) expression during induction of anagen hair growth Reviewed

Sugawara Koji, Tsuruta Daisuke, Kobayashi Hiromi, Ikeda Kazuo, Hopkinson Susan B., Jones Jonathan C. R., Ishii Masamitsu

JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY   55 ( 1 )   43 - 55   2007.01（ ISSN:0022-1554 ）

Dissection of the Heart : A Useful Guide to Understanding the Three-dimensional Gross Anatomy Reviewed

SAKABE Masahide, ABE Mikiko, NAKATANI Kazuki, IKEDA Kazuo, YOSHIYAMA Minoru, NAKAJIMA Yuji

Acta anatomica Nipponica   81 ( 4 )   117 - 124   2006.12（ ISSN:00227722 ）

[Dissection of the heart: a useful guide to understanding the three-dimensional gross anatomy]. Reviewed

Sakabe M, Abe M, Nakatani K, Ikeda K, Yoshiyamal M, Nakajima Y

Kaibogaku zasshi. Journal of anatomy   81 ( 4 )   117 - 24   2006.12（ ISSN:0022-7722 ）

Genipin suppression of fibrogenic behaviors of the alpha-TN4 lens epithelial cell line. Reviewed

Kitano A, Saika S, Yamanaka O, Reinach PS, Ikeda K, Okada Y, Shirai K, Ohnishi Y

Journal of cataract and refractive surgery   32 ( 10 )   1727 - 35   2006.10（ ISSN:0886-3350 ）

Gene transfer of Smad7 modulates injury-induced conjunctival wound healing in mice Reviewed

Yamanaka Osamu, Ikeda Kazuo, Saika Shizuya, Miyazaki Ken-ichi, Ooshima Akira, Ohnishi Yoshitaka

MOLECULAR VISION   12 ( 95 )   841 - 851   2006.08（ ISSN:1090-0535 ）

Interleukin-7 modulates extracellular matrix production and TGF-beta signaling in cultured human subconjunctival fibroblasts Reviewed

Yamanaka O, Saika S, Ikeda K, Miyazaki KI, Ohnishi Y, Ooshima A

CURRENT EYE RESEARCH   31 ( 6 )   491 - 499   2006.06（ ISSN:0271-3683 ）

Loss of tumor necrosis factor alpha potentiates transforming growth factor beta-mediated pathogenic tissue response during wound healing. Reviewed

Saika S, Ikeda K, Yamanaka O, Flanders KC, Okada Y, Miyamoto T, Kitano A, Ooshima A, Nakajima Y, Ohnishi Y, Kao WW

The American journal of pathology   168 ( 6 )   1848 - 60   2006.06（ ISSN:0002-9440 ）

TNP-470 blockage of VEGF synthesis is dependent on MAPK/COX-2 signaling pathway in PDGF-BB-activated hepatic stellate cells Reviewed

Wang YQ, Luk JM, Chu AC, Ikeda K, Man K, Kaneda K, Fan ST

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   341 ( 1 )   239 - 244   2006.03（ ISSN:0006-291X ）

Expression of NCAM in activated portal fibroblasts during regeneration of the rat liver after partial hepatectomy Reviewed

NAKATANI Kazuki, TANAKA Hisao, IKEDA Kazuo, SAKABE Masahide, KADOYA Hirokazu, SEKI Shuichi, KANEDA Kenji, NAKAJIMA Yuji

Archives of histology and cytology   69 ( 1 )   61 - 72   2006.03（ ISSN:09149465 ）

BMP-7 opposes TGF-beta 1-mediated collagen induction in mouse pulmonary myofibroblasts through Id2 Reviewed

Izumi N, Mizuguchi S, Inagaki Y, Saika S, Kawada N, Nakajima Y, Inoue K, Suehiro S, Friedman SL, Ikeda K

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY   290 ( 1 )   L120 - L126   2006.01（ ISSN:1040-0605 ）

Adenoviral gene transfer of BMP-7, Id2, or Id3 suppresses injury-induced epithelial-to-mesenchymal transition of lens epithelium in mice Reviewed

Saika S, Ikeda K, Yamanaka O, Flanders KC, Ohnishi Y, Nakajima Y, Muragaki Y, Ooshima A

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY   290 ( 1 )   C282 - C289   2006.01（ ISSN:0363-6143 ）

Rho kinases regulate endothelial invasion and migration during valvuloseptal endocardial cushion tissue formation Reviewed

Sakabe M, Ikeda K, Nakatani K, Kawada N, Imanaka-Yoshida K, Yoshida T, Yamagishi T, Nakajima Y

DEVELOPMENTAL DYNAMICS   235 ( 1 )   94 - 104   2006.01（ ISSN:1058-8388 ）

Heart myofibrillogenesis occurs in isolated chick posterior blastoderm: A culture model Reviewed

Matsui Hiroko, Sakabe Masahide, Sakata Hirokazu, Nakatani Kazuki, Ikeda Kazuo, Fukui Mitsuru, Ando Katsumi, Yamagishi Toshiyuki, Nakajima Yuji

JAPAN SOCIETY OF HISTOCHEMISTRY AND CYTOCHEMISTRY　ACTA HISTOCHEMICA ET CYTOCHEMICA   39 ( 5 )   139 - 144   2006（ ISSN:0044-5991 ）

Induction of initial cardiomyocyte alpha-actin - Smooth muscle alpha-actin - in cultured avian pregastrula epiblast: A role for nobal and BMP antagonist Reviewed

Matsui H, Ikeda K, Nakatani K, Sakabe M, Yamagishi T, Nakanishi T, Nakajima Y

DEVELOPMENTAL DYNAMICS   233 ( 4 )   1419 - 1429   2005.08（ ISSN:1058-8388 ）

Cell type-specific intervention of transforming growth factor beta/Smad signaling suppresses collagen gene expression and hepatic fibrosis in mice Reviewed

Inagaki Y, Kushida M, Higashi K, Itoh J, Higashiyama R, Hong YY, Kawada N, Namikawa K, Kiyama H, Bou-Gharios G, Watanabe T, Ikeda K

GASTROENTEROLOGY   129 ( 1 )   259 - 268   2005.07（ ISSN:0016-5085 ）

Inhibition of p38MAP kinase suppresses fibrotic reaction of retinal pigment epithelial cells Reviewed

Saika S, Yamanaka O, Ikeda K, Kim-Mitsuyama S, Flanders KC, Yoo JY, Roberts AB, Nishikawa-Ishida I, Ohnishi Y, Muragaki Y, Ooshima A

LABORATORY INVESTIGATION   85 ( 7 )   838 - 850   2005.07（ ISSN:0023-6837 ）

Expression of Smad7 in mouse eyes accelerates healing of corneal tissue after exposure to alkali Reviewed

Saika S, Ikeda K, Yamanaka O, Miyamoto T, Ohnishi Y, Sato M, Muragaki Y, Ooshima A, Nakajima Y, Kao WWY, Flanders KC, Roberts AB

AMERICAN JOURNAL OF PATHOLOGY   166 ( 5 )   1405 - 1418   2005.05（ ISSN:0002-9440 ）

Therapeutic effect of topical administration of SN50, an inhibitor of nuclear factor-kappaB, in treatment of corneal alkali burns in mice. Reviewed

Saika S, Miyamoto T, Yamanaka O, Kato T, Ohnishi Y, Flanders KC, Ikeda K, Nakajima Y, Kao WW, Sato M, Muragaki Y, Ooshima A

The American journal of pathology   166 ( 5 )   1393 - 403   2005.05（ ISSN:0002-9440 ）

FK778単独およびFK778・FK506併用によるラット肝移植後免疫反応の抑制効果(第105回日本外科学会定期学術集会)

山本 訓史, 奥田 豊一, 山崎 圭一, 竹村 茂一, 南山 幸子, 池田 一雄, 田中 宏, 裴 正寛, 高台 真太郎, 久保 正二

日本外科学会雑誌   106 ( 0 )   414   2005.04（ ISSN:03014894 ）

Therapeutic effects of adenoviral gene transfer of bone morphogenic proteinalkali injury model in mice Reviewed

Saika S, Ikeda K, Yamanaka O, Flanders KC, Nakajima Y, Miyamoto T, Ohnishi Y, Kao WWY, Muragaki Y, Ooshima A

LABORATORY INVESTIGATION   85 ( 4 )   474 - 486   2005.04（ ISSN:0023-6837 ）

FK778 controls acute rejection after rat liver allotransplantation showing positive interaction with FK506 Reviewed

Yamamoto S, Okuda T, Yamasaki K, Tanaka H, Takemura S, Minamiyama Y, Ikeda K, Hirohashi K, Suehiro S

TRANSPLANTATION PROCEEDINGS   37 ( 1 )   126 - 129   2005（ ISSN:0041-1345 ）

Transient adenoviral gene transfer of Smad7 prevents injury-induced epithelial-mesenchymal transition of lens epithelium in mice Reviewed International coauthorship

Saika S, Ikeda K, Yamanaka O, Sato M, Muragaki Y, Ohnishi Y, Ooshima A, Nakajima Y, Namikawa K, Kiyama H, Flanders KC, Roberts AB

Lab Invest   84 ( 10 )   1259 - 1270   2004.10

Sulfur-containing amino acids attenuate the development of liver fibrosis in rats through down-regulation of stellate cell activation Reviewed International coauthorship

Matsui H, Ikeda K, Nakajima Y, Horikawa S, Imanishi Y, Kawada N

J Hepatol   40 ( 6 )   917 - 925   2004.06

Regulatory role of vHL/HIF-1alpha in hypoxia-induced VEGF production in hepatic stellate cells Reviewed International coauthorship

Wang YQ, Luk JM, Ikeda K, Man K, Chu AC, Kaneda K, Fan ST

Biochem Biophys Res Commun   317 ( 2 )   358 - 362   2004.04

Localization of lymphocyte apoptosis in murine lymphoid tissues after stimulation of natural killer T cells with alpha-galactosylceramide Reviewed International coauthorship

Fujii H, Seki S, Nakatani K, Ikeda K, Ikemoto M, Nakajima Y, Arakawa T, Kaneda K

Arch Histol Cytol   66 ( 5 )   397 - 406   2003.12

Carbenoxolone inhibits DNA synthesis and collagen gene expression in rat hepatic stellate cells in culture Reviewed International coauthorship

Uyama N, Shimahara Y, Okuyama H, Kawada N, Kamo S, Ikeda K, Yamaoka Y

J Hepatol   39 ( 5 )   749 - 755   2003.11

Interferon alfa down-regulates collagen gene transcription and suppresses experimental hepatic fibrosis in mice Reviewed International coauthorship

Inagaki Y, Nemoto T, Kushida M, Sheng Y, Higashi K, Ikeda K, Kawada N, Shirasaki F, Takehara K, Sugiyama K, Fujii M, Yamauchi H, Nakao A, de Crombrugghe B, Watanabe T, Okazaki I

Hepatology   38 ( 4 )   890 - 899   2003.10

Stimulation of proliferation of rat hepatic stellate cells by galectin-1 and galectin-3 through different intracellular signaling pathways Reviewed International coauthorship

Maeda N, Kawada N, Seki S, Arakawa T, Ikeda K, Iwao H, Okuyama H, Hirabayashi J, Kasai K, Yoshizato K

J Biol Chem   278 ( 21 )   18938 - 18944   2003.05

Oxidative stress-induced cell death of human oral neutrophils Reviewed International coauthorship

Sato EF, Higashino M, Ikeda K, Wake R, Matsuo M, Utsumi K, Inoue M

Am J Physiol Cell Physiol   284 ( 4 )   C1048 - 1053   2003.04

Apoptosis of T cells in the hepatic fibrotic tissue of the rat: a possible inducing role of hepatic myofibroblast-like cells Reviewed International coauthorship

Kobayashi S, Seki S, Kawada N, Morikawa H, Nakatani K, Uyama N, Ikeda K, Nakajima Y, Arakawa T, Kaneda K

Cell Tissue Res   311 ( 3 )   353 - 364   2003.03

Expression of SPARC by activated hepatic stellate cells and　its correlation with the stages of fibrogenesis in human chronic hepatitis Reviewed International coauthorship

Nakatani K, Seki S, Kawada N, Kitada T, Yamada T, Sakaguchi H, Kadoya H,　Ikeda K, Kaneda K

Virchows Arch   441 ( 5 )   466 - 474   2002.11

Discoidin domain receptor 2　interacts with Src and Shc following its activation by type I collagen Reviewed International coauthorship

Ikeda K, Wang LH, Torres R, Zhao H, Olaso E, Eng FJ, Labrador P, Klein R,　Lovett D, Yancopoulos GD, Friedman SL, Lin HC

J Biol Chem   277 ( 21 )   19206 - 19212   2002.05

Leptin in hepatic　fibrosis: evidence for increased collagen production in stellate cells and lean　littermates of ob/ob mice Reviewed International coauthorship

Saxena NK, Ikeda K, Rockey DC, Friedman SL, Anania FA

Hepatology   35 ( 4 )   762 - 771   2002.04

Discoidin domain receptor 2 regulates fibroblast proliferation and migration through the extracellular matrix in association with transcriptional activation of matrix metalloproteinase-2 Reviewed International coauthorship

Olaso E, Labrador JP, Wang L, Ikeda K, Eng FJ, Klein R, Lovett DH, Lin HC, Friedman SL

J Biol Chem   277 ( 5 )   3606 - 3613   2002.02

DDR2 receptor promotes MMP-2-mediated proliferation and invasion by hepatic stellate cells Reviewed International coauthorship

Olaso E, Ikeda K, Eng FJ, Xu L, Wang LH, Lin HC, Friedman SL

J Clin Invest   108 ( 9 )   1369 - 1378   2001.11

Cellular prion protein expression in non-ciliated epithelial cells (Clara cells) of proliferating bronchioles during bleomycin-induced pulmonary fibrosis in hamster Reviewed International coauthorship

Kadoya H, Ikeda K, Nakatani K, Seki S, Kaneda K

Osaka City Med J   47 ( 1 )   23 - 32   2001.06

Prevention of rat hepatic fibrosis by the protease inhibitor, camostat mesilate, via reduced generation of active TGF-beta Reviewed International coauthorship

Okuno M, Akita K, Moriwaki H, Kawada N, Ikeda K, Kaneda K, Suzuki Y, Kojima S

Gastroenterology   120 ( 7 )   1784 - 1800   2001.06

Ultrastructure of early phase hepatic metastasis of human colon carcinoma cells with special reference to desmosomal junctions with hepatocytes Reviewed International coauthorship

Shimizu S, Yamada N, Sawada T, Ikeda K, Nakatani K, Seki S, Kaneda K, Hirakawa K

Pathol Int   50 ( 12 )   953 - 959   2000.12

In vivo and in vitro interactions between human colon carcinoma cells and hepatic stellate cells Reviewed International coauthorship

Shimizu S, Yamada N, Sawada T, Ikeda K, Kawada N, Seki S, Kaneda K, Hirakawa K

Jpn J Cancer Res   91 ( 12 )   1285 - 1295   2000.12

Clinicopathological characterization of prion: a novel marker of activated human hepatic stellate cells Reviewed International coauthorship

Kitada T, Seki S, Ikeda K, Nakatani K, Sakaguchi H, Kawada N, Kadoya H, Kaneda K

J Hepatol   33 ( 5 )   751 - 757   2000.11

Inhibition of hepatic stellate cell proliferation and activation by the semisynthetic analogue of fumagillin TNP-470 in rats Reviewed International coauthorship

Wang YQ, Ikeda K, Ikebe T, Hirakawa K, Sowa M, Nakatani K, Kawada N, Kaneda K

Hepatology   32 ( 5 )   980 - 989   2000.11

Preventive effect of preoperative portal vein ligation on endotoxin-induced hepatic failure in hepatectomized rats is associated with reduced tumour necrosis factor alpha production Reviewed International coauthorship

Yachida S, Ikeda K, Kaneda K, Goda F, Maeba T, Maeta H

Br J Surg   87 ( 10 )   1382 - 1390   2000.10

Phenotypical and morphological alterations to rat sinusoidal endothelial cells in arterialized livers after portal branch ligation Reviewed International coauthorship

Yamasaki M, Ikeda K, Nakatani K, Yamamoto T, Kawai Y, Hirohashi K, Kinoshita H, Kaneda K

Arch Histol Cytol   62 ( 5 )   401 - 411   1999.12

Expression of cyclins D1, D2 and E correlates with proliferation of rat stellate cells in culture Reviewed International coauthorship

Kawada N, Ikeda K, Seki S, Kuroki T

J Hepatol   30 ( 6 )   1057 - 1064   1999.06

In vitro migratory potential of rat quiescent hepatic stellate cells and its augmentation by cell activation Reviewed International coauthorship

Ikeda K, Wakahara T, Wang YQ, Kadoya H, Kawada N, Kaneda K

Hepatology   29 ( 6 )   1760 - 1767   1999.06

Expression of cellular prion protein in activated hepatic stellate cells Reviewed International coauthorship

Ikeda K, Kawada N, Wang YQ, Kadoya H, Nakatani K, Sato M, Kaneda K

Am J Pathol   153 ( 6 )   1695 - 1700   1998.12

Immunohistochemical and ultrastructural analyses of in situ activation of hepatic stellate cells around Propionibacterium acnes-induced granulomas in the rat liver Reviewed International coauthorship

Tsuji N, Kawada N, Ikeda K, Kinoshita H, Kaneda K

J Submicrosc Cytol Pathol   29 ( 1 )   125 - 133   1997.01

Morphological study of endothelin-1-induced contraction of cultured hepatic stellate cells on hydrated collagen gels Reviewed International coauthorship

Kawada N, Harada K, Ikeda K, Kaneda K

Cell Tissue Res   286 ( 3 )   477 - 486   1996.12

Mechanism that regulates nitric oxide production by lipopolysaccharide-stimulated rat Kupffer cells Reviewed International coauthorship

Ikeda K, Kubo S, Hirohashi K, Kinoshita H, Kaneda K, Kawada N, Sato EF, Inoue M

Physiol Chem Phys Med NMR   28 ( 4 )   239 - 253   1996

The ultrastructure, kinetics and intralobular distribution of apoptotic hepatocytes after portal branch ligation with special reference to their relationship to necrotic hepatocytes Reviewed International coauthorship

Ikeda K, Kinoshita H, Hirohashi K, Kubo S, Kaneda K

Arch Histol Cytol   58 ( 2 )   171 - 184   1995.06

【肝胆膵の線維化;研究と診療の最近の進歩】肝臓の線維化　研究の進歩　肝線維化とマイクロRNA

池田 一雄, 小川 智弘, 河田 則文

肝胆膵   65 ( 2 )   203 - 209   2012.08（ ISSN:0389-4991 ）

肝線維化におけるLawsone結合タンパク質の同定ならびに機能解析 Domestic conference

大黒　敦子、松原　勤、松原　三佐子、湯浅　秀人、宇留島　隼人、河田　則文、池田　一雄

129回日本解剖学会総会・全国学術集会  2024.03 

肝内胆管癌の臨床検体から抽出したmicroRNA-3648と癌抑制遺伝子SKIの関係 Domestic conference

川村 悦史、松原 勤、大黒 敦子、武藤 芳美、小田桐 直志、元山 宏行、小谷 晃平、小塚 立蔵、萩原 淳司、藤井 英樹、打田 佐和子、榎本 大、池田 一雄、河田 則文

第45回日本肝臓学会西部会  2023.12 

老化肝星細胞におけるERKリン酸化亢進とSMAD4発現抑制の分子機序解明 Domestic conference

中居 暉、松原 勤、宇留島 隼人、湯浅 秀人、池田 一雄

第37回肝類洞壁細胞研究会学術集会  2023.12 

肝細胞脂質代謝におけるプリオンの機能解析 Domestic conference

辜 瓊雅、宇留島 隼人、松原 勤、湯浅 秀人、大黒 敦子、Hung Vu Thai、Nguyen Duc Vien、安藤 美玖、中居 暉、池田 一雄

第37回肝類洞壁細胞研究会学術集会  2023.12 

増殖様式が異なるHepG2細胞2系統間の遺伝子発現比較と肝機能改善剤スクリーニングシステムの構築 Domestic conference

宇留島隼人、松原勤、湯浅秀人、大黒敦子、Gu Qiongya、Hung Vu Thai、Nguyen Duc Vien、安藤美玖、中居暉、池田一雄

第37回肝類洞壁細胞研究会学術集会  2023.12 

肝内胆管癌の臨床検体から抽出したmicroRNA-3648と癌抑制遺伝子SKIの関係

川村 悦史, 松原 勤, 大黒 敦子, 武藤 芳美, 小田桐 直志, 元山 宏行, 小谷 晃平, 小塚 立蔵, 萩原 淳司, 藤井 英樹, 打田 佐和子, 榎本 大, 池田 一雄, 河田 則文

肝臓  2023.10  (一社)日本肝臓学会

非アルコール性脂肪肝炎の病態変化に関連した因子の探索 Domestic conference

安藤美玖、松原勤、大黒敦子、VU THAI HUNG、門野千穂、湯浅秀人、宇留島隼人、池田一雄

第30回肝細胞研究会  2023.08 

老化肝星細胞におけるERKリン酸化亢進の意義 Domestic conference

中居 暉、松原 勤、高田 さゆり、安藤 美玖、宇留島 隼人、湯浅 秀人、池田 一雄

第30回肝細胞研究会  2023.08 

肝星細胞のスパイン形成および活性化抑制に関わる細胞膜タンパク質の同定と機能解明 Domestic conference

井上 喜来々、松原 三佐子、松原 勤、宇留島 隼人、湯浅 秀人、大黒 敦子、池田 一雄、吉里 勝利、河田 則文、鈴木孝幸

第30回肝細胞研究会  2023.08 

Aged-Related Changes in Hepatic Mesenchymal Cells (HMCs) Domestic conference

Nguyen Duc Vien, Tsutomu Matsubara, Atsuko Daikoku, Miku Ando, Chiho Kadono, Moe Higuchi, Hikaru Nakai, Hideto Yuasa, Hayato Urushima, Kazuo Ikeda

2023.07 

Gene Expression Analysis Related to Pathological Changes in Non-alcoholic Steatohepatitis Domestic conference

Vu Thai Hung, Tsutomu Matsubara, Atsuko Daikoku, Miku Ando, Chiho Kadono, Moe Higkuchi, Hideto Yuasa, Hayato Urushima, Kazuo Ikeda

2023.07 

Induction of apoptosis in hepatocellular carcinoma-derived cells by Oligonol®, a low-molecular-weight polyphenol derived from lychee fruit International conference

Hideto Yuasa, Hayato Urushima, Tsutomu Matsubara, Kazuo Ikeda

The 31st Annual Meeting of International Congress on Nutrition and Integrative Medicine  2023.07 

Hepatocyte Regeneration-Promoting Effects of AHCCⓇ in a Partial Hepatectomy Model International conference

Qiongya Gu, Hayato Urushima,Chiho Kadono,Atsuko Daikoku, Hideto Yuasa,Tsutomu Matsubara,Kazuo Ikeda

The 31st Annual Meeting of International Congress on Nutrition and Integrative Medicine  2023.07 

AHCC® inhibited hepatic stellate cells activation by induction of cytoglobin expression through Toll-like receptor 2-JNK pathway and suppressed liver fibrosis International conference

Hayato Urushima, Tsutomu Matsubara, Gu Qiongya, Atsuko Daikoku, Chiho Kadono, Hideto Yuasa, Kazuo Ikeda

The 31st Annual Meeting of International Congress on Nutrition and Integrative Medicine  2023.07 

肝星細胞活性化抑制作用を有する肝細胞膜タンパク質の探索

井上 喜来々, 松原 三佐子, 松原 勤, 大黒 敦子, 池田 一雄, 河田 則文

肝臓  2023.04  (一社)日本肝臓学会

Lawsoneが示す抗線維化作用機序の解明 Domestic conference

大黒敦子、松原勤、松原三佐子、湯浅秀人、宇留島隼人、河田則文、池田一雄

第128回日本解剖学会総会・全国学術集会  2023.03  日本解剖学会

Age-related changes in hepatic mesenchymal cells Domestic conference

2023.03 

Gene expression analysis related to pathological changes in non-alcoholic steatohepatitis Domestic conference

2023.03 

肝星細胞研究：今昔 Invited Domestic conference

池田一雄

第36回肝類洞壁細胞研究会学術集会  2022.12  肝類洞壁細胞研究会

肝転移におけるがん細胞‐肝類洞内皮細胞相互作用機構の解明 Domestic conference

Huu Hoang Truong、松原三佐子、湯浅秀人、Le Thi Thanh Thuy、松原勤、池田一雄、吉里勝利、河田則文

第36回肝類洞壁細胞研究会学術集会  2022.12  肝類洞壁細胞研究会

肝細胞膜による肝星細胞活性化抑制作用 Domestic conference

井上喜来々、松原三佐子、松原勤、宇留島隼人、湯浅秀人、大黒敦子、池田一雄、吉里勝利、鈴木孝幸、河田則文

第36回肝類洞壁細胞研究会学術集会  2022.12  肝類洞壁細胞研究会

電子顕微鏡を用いた肝類洞壁構成細胞の三次元的構造解析 Domestic conference

湯浅秀人、太田啓介、大黒敦子、宇留島隼人、松原勤、池田一雄

第36回肝類洞壁細胞研究会学術集会  2022.12  肝類洞壁細胞研究会

肝星細胞研究：今昔 Invited Domestic conference

池田一雄

第36回肝類洞壁細胞研究会学術集会  2022.12  肝類洞壁細胞研究会

肝細胞と肝星細胞との細胞膜を介した直接的なクロストーク Domestic conference

井上喜来々、松原三佐子、松原勤、宇留島隼人、湯浅秀人、大黒敦子、池田一雄、吉里勝利、鈴木孝幸、河田則文

第45回日本分子生物学会年会  2022.11  日本分子生物学会

肝細胞膜による肝星細胞の脱活性化機構の解明 Domestic conference

井上喜来々、松原三佐子、松原勤、宇留島隼人、湯浅秀人、大黒敦子、池田一雄、吉里勝利、河田則文

第29回日本門脈圧亢進症学会総会  2022.09  日本門脈圧亢進症学会

抗線維化薬としてのLawsoneの評価と作用機序の解明 Domestic conference

大黒敦子、松原勤、松原三佐子、湯浅秀人、宇留島隼人、河田則文、池田一雄

第29回肝細胞研究会  2022.08  肝細胞研究会

肝細胞の肝星細胞活性化抑制作用における肝細胞膜の重要性 Domestic conference

井上喜来々、松原三佐子、松原勤、宇留島隼人、湯浅秀人、大黒敦子、池田一雄、吉里勝利、鈴木孝幸、河田則文

第29回肝細胞研究会  2022.08  肝細胞研究会

AHCCⓇ inhibited hepatic stellate cells activation and suppressed liver fibrosis progression via induction of cytoglobin International conference

Hayato Urushima, Hideto Yuasa, Tsutomu Matsubara, and Kazuo Ikeda

International Congress on Nutrition and Integrative Medicine  2022.07 

Oligonol, a standardized oligomerized-polyonenol from Litchi chinensis fruit extract, incrases E-cadherin expression in hepatocyte International conference

Hideto Yuasa, Hayato Urushima, Tsutomu Matsubara, Kazuo Ikeda

International Congress on Nutrition and Integrative Medicine  2022.07 

肝硬変治療薬を目指した化合物スクリーニングとその分子機序解析

松原勤、大黒敦子、池田一雄

第58回日本肝臓学会総会  2022.06  日本肝臓学会

肝硬変治療薬を目指した化合物スクリーニングとその分子機序解析

松原勤, 大黒敦子, 池田一雄

第58回日本肝臓学会総会  2022.06  日本肝臓学会

肝線維化研究Revisited-肝臓学のBiologyからTranslationalへ　肝硬変治療薬を目指した化合物スクリーニングとその分子機序解析

松原 勤, 大黒 敦子, 池田 一雄

肝臓  2022.04  (一社)日本肝臓学会

臨床検体から抽出した癌抑制遺伝子SKIによる胆管癌細胞周期の抑制

川村 悦史, 松原 勤, 大黒 敦子, 武藤 芳美, 高田 さゆり, 新川 寛二, 木下 正彦, 小田桐 直志, 小谷 晃平, 元山 宏行, 小塚 立蔵, 松原 美三子, 萩原 淳司, 藤井 英樹, 打田 佐和子, 田中 肖吾, 竹村 茂一, 榎本 大, 田守 昭博, 久保 正二, 池田 一雄, 河田 則文

肝臓  2021.11  (一社)日本肝臓学会

Inter-organ communication networks maintain organismal homeostasis　肝脂質の恒常性維持における臓器ネットワーク(The organic networks for hepatic lipid homeostasis)

Matsubara Tsutomu, Ikeda Kazuo

The Journal of Physiological Sciences  2021.08  (一社)日本生理学会

肝星細胞の培養条件下における静止型形態の維持について Domestic conference

湯浅秀人、宇留島隼人、髙山実紗子、松原勤、池田一雄

第34回肝類洞壁細胞研究会  2020.12 

AHCC®に含まれる肝星細胞活性化抑制能を有する新規活性成分の探索 Domestic conference

髙山実紗子、宇留島隼人、湯浅秀人、松原勤、岡田芳治、池谷幸信、池田一雄

第34回肝類洞壁細胞研究会  2020.12 

肝細胞との接着結合による肝星細胞活性抑制と肝機能単位Stellonの再認識 Domestic conference

宇留島隼人、湯浅秀人、松原勤、井上孝二、和氣健二郎、池田一雄

第34回肝類洞壁細胞研究会  2020.12 

胆管細胞がん治療のためのSKI利用可能性に関するin vitro評価(In vitro assessment of SKI availability for the cholangiocarcinoma therapy.)

Kawamura Etsushi, Matsubara Tsutomu, Yuasa Hideto, Urushima Hayato, Enomoto Masaru, Tamori Akihiro, Kubo Shoji, Ikeda Kazuo, Kaneko Akira, Kawada Norifumi

グローバルヘルス合同大会プログラム・抄録集  2020.11  グローバルヘルス合同大会事務局

老化肝星細胞におけるTGFbetaシグナルの変化 Domestic conference

松原勤、高田さゆり、小田桐直志、宇留島隼人、河田則文、池田一雄

第125回日本解剖学会  2020.03 

肝星細胞におけるfilopodia関連タンパク質の発現解析 Domestic conference

湯浅秀人、宇留島隼人、松原勤、池田一雄

第125回日本解剖学会  2020.03 

正常ないし障害肝の肝星細胞におけるfilopodia関連タンパク質の発現解析 Domestic conference

湯浅秀人、宇留島隼人、松原勤、池田一雄

第33回肝類洞壁細胞研究会  2019.12 

非アルコール性脂肪性肝炎におけるCytoglobin発現制御機構 Domestic conference

翁良徳、松原三佐子、松原勤、大黒敦子、池田一雄、吉里勝利、河田則文

第33回肝類洞壁細胞研究会  2019.11 

若年胆管癌組織を使った癌抑制遺伝子の探索

川村 悦史, 松原 勤, 樋口 萌, 出口 早苗, 高田 さゆり, 大黒 敦子, 伊藤 得路, 木下 正彦, 松原 三佐子, 小田桐 直志, 田中 肖吾, 竹村 茂一, 村上 善基, 榎本 大, 田守 昭博, 久保 正二, 祝迫 惠子, 池田 一雄, 河田 則文

肝臓  2019.11  (一社)日本肝臓学会

老化肝星細胞におけるTGFβシグナル変化についての解析

高田 さゆり, 松原 勤, 樋口 萌, 小田桐 直志, 松原 三佐子, 河田 則文, 池田 一雄

肝臓  2019.11  (一社)日本肝臓学会

Downregulation of cytoglobin by TGF-β leads to hydroxyl radical-induced oxidative DNA damage in human HSCs International conference

Okina Y, Sato-Matsubara M, Matsubara T, Daikoku A, Rombouts K, Fujii H, Ikeda K, Pinzani M, Kawada N.

JSH:International Liver Conference 2019  2019.10 

TGF-β1 transcriptionally repressed cytoglobin expression and enhanced H2O2-induced oxidative DNA damage in activated HSCs International conference

Sato-Matsubara M, Okina Y, Matsubara T, Daikoku A, Rombouts K, Thuy LTT, Fujii H, Ikeda K, Yoshizato K, Pinzani M, Kawada N

20th International Symposium on Cells of the Hepatic Sinusoid  2019.09 

Stellate cells initiate the activation by the loss of adherens junction with hepatocytes International conference

Urushima H, Yuasa H, Matsubara T, Hara Y, Inoue K, Wake K, Sato T, Ikeda K

20th International Symposium on Cells of the Hepatic Sinusoid  2019.09 

門亢症の病態解明～基礎から臨床へ～　肝硬変時の低ナトリウム血症による低浸透圧環境が門脈圧亢進に及ぼす影響

宇留島 隼人, 松原 勤, 湯浅 秀人, 河田 則文, 池田 一雄

日本門脈圧亢進症学会雑誌  2019.09  (一社)日本門脈圧亢進症学会

Oligonol ameliorates hepatic fibrosis through the inhibition of FAK-YAP pathway in hepatic stellate cells International conference

Urushima H, Yuasa H,　Takayama M, Matsubara T,Ikeda K.

27 th International Congress on Nutrition and Integrative Medicine  2019.07 

Search for novel component with ability to suppress the hepatic stellate cell acitivation in AHCC International conference

Takayama M, Urushima H, Yuasa H,Matsubara T, Ikeda K.

27 th International Congress on Nutrition and Integrative Medicine  2019.07 

肝細胞―肝星細胞間の接着結合喪失は肝星細胞活性化に寄与する Domestic conference

宇留島隼人、湯浅秀人、松原勤、井上孝二、和氣健二郎、佐藤哲二、池田一雄

第124回日本解剖学会総会  2019.03 

肝星細胞活性化と肝障害 　シンポジウム；肝臓、最新の話題と理論 Invited Domestic conference

池田一雄、松原勤、宇留島隼人、湯浅秀人

第124回日本解剖学会総会  2019.03 

四塩化炭素投与ラット肝炎モデルにおける肝星細胞活性化の検討 Domestic conference

原矢委子、黒田範行、井上孝二、松原勤、宇留島隼人、池田一雄、和氣健二郎、佐藤哲二

第124回日本解剖学会総会  2019.03 

肝細胞―星細胞間接着と星細胞活性化との関連 Domestic conference

宇留島隼人、松原勤、湯浅秀人、井上孝二、和氣健二郎、佐藤哲二、池田一雄

第32回肝類洞壁細胞研究会  2018.12 

脂肪性肝炎の進展におけるCYGB保護作用の分子機序解析 Domestic conference

松原三佐子、翁良徳、松原 勤、大黒 敦子、池田 一雄、吉里　勝利、河田 則文

第32回肝類洞壁細胞研究会  2018.12 

Promoter Activity of Human Cytoglobin Is Regulated By TGFβ1‐Smad2‐SP3 Pathway in Human, but Not Mouse, Hepatic Stellate Cells International conference

Okina Y, Sato-Matsubara M, Matsubara T, Daikoku A, Rombouts K, Fujii H, Ikeda K, Pinzani M, Kawada N

69th Annual Meeting of the American Association for the Study of Liver Diseases  2018.11 

TGFbeta1 reduces Cytoglobin expression via Smad2-SP3 pathway in human, but not mouse, hepatic stellate cells International conference

Sato-Matsubara M, Okina Y, Matsubara T, Daikoku A, Fujii H, Rombouts K, Ikeda K, Yoshizato K, Pinzani M, Kawada N

AASLD single topic conference; Hepatic fibrosis  2018.09 

肝細胞と肝星細胞の共培養による肝星細胞の活性化抑制 Domestic conference

松原三佐子、松原 勤、宇留島隼人、大黒 敦子、池田 一雄、森浦芳枝、門野千穂、河田 則文、吉里　勝利

第25回肝細胞研究会　  2018.07 

Oligonol suppresses activation of hepatic stellate cell by inhibition of YAP/TAZ pathway International conference

Urushima H, Matsubara T, Ikeda K.

26 th International Congress on Nutrition and Integrative Medicine  2018.07 

ヒト肝星細胞における脱活性化誘導制御機構の解明 Domestic conference

松原三佐子、大黒 敦子、松原 勤、池田 一雄、吉里　勝利、河田 則文

第54回　日本肝臓学会総会  2018.06 

ヒト肝星細胞における老化関連分泌因子の遺伝子発現解析 Domestic conference

「松原　勤、他」

第123回日本解剖学会総会  2018.03 

肝星細胞のspineを介した肝細胞との接着の意義 Domestic conference

「宇留島隼人、他」

第123回日本解剖学会総会  2018.03 

ヒト肝星細胞の老化関連分泌表現型解析 Domestic conference

「小田桐直志、他」

第31回肝類洞壁細胞研究会学術集会  2017.11 

低浸透圧環境は活性化肝星細胞や肝がん細胞のアポトーシスを抑制する Domestic conference

「宇留島隼人、他」

第31回肝類洞壁細胞研究会学術集会  2017.11 

肝星細胞におけるTGF-b1/Smadシグナルを介したCytoglobin発現制御機構 Domestic conference

「松原三佐子、他」

第31回肝類洞壁細胞研究会学術集会  2017.11 

ヒト肝星細胞の老化関連分泌表現型(SASP)解析

小田桐 直志, 松原 勤, 池田 一雄

肝臓  2017.09  (一社)日本肝臓学会

肝星細胞を標的とした細胞表面抗原の樹立

吹田 安佐詠, 松原 三佐子, 松原 勤, 池田 一雄, 河田 則文

肝臓  2017.04  (一社)日本肝臓学会

肝星細胞の脱活性化を誘導するサイトグロビン発現促進機構の解析

松原 三佐子, 大黒 敦子, 松原 勤, 池田 一雄, 河田 則文

肝臓  2016.04  (一社)日本肝臓学会

ヒト肝星細胞におけるサイトグロビン遺伝子発現調節機構の分子機序解析

松原 三佐子, 大黒 敦子, 松原 勤, 池田 一雄, 河田 則文

肝臓  2015.11  (一社)日本肝臓学会

抗線維化in vitro評価系の構築と抗線維化物質の探索

松原 勤, 大黒 敦子, 松原 三佐子, 池田 一雄, 河田 則文

肝臓  2015.11  (一社)日本肝臓学会

肝星細胞によるサイトグロビンの発現に対する酸素分圧と基底膜成分の影響

沖田 大和, 松原 勤, 池田 一雄, 河田 則文, 吉里 勝利

肝臓  2015.11  (一社)日本肝臓学会

Enhanced endoplasmic reticulum stress response has a protective role in acetaminophen-induced liver injury in mice International conference

Sogabe N, Matsubara T, Teranishi Y, Nakatani K, Kawada N, Ikeda K.

18th International Symposium on Cells of the Hepatic Sinusoid  2015.10 

Identification of FGF2 as a Cytoglobin regulatory factor leading to inactivation of hepatic stellate cells International conference

Sato-Matsubara M, Matsubara T, Daikoku A, Ikeda K, Kawada N.

66th Annual Meeting of the American Association for the Study of Liver Diseases   2015.10 

A protective role of C/EBP homologous protein in acetaminophen-induced acute hepatocyte damage in mice International conference

Matsubara T, Kitamura K, Sogabe N, Teranishi Y, Nakatani K, Kawada N, Ikeda K.

66th Annual Meeting of the American Association for the Study of Liver Diseases  2015.10 

FGF2 deactivates human hepatic stellate cells following induction of cytoglobin and down-regulation of αSMA expressions International conference

Sato-Matsubara M, Daikoku A, Matsubara T, Rombouts K, Ikeda K, Pinzani M, Kawada N

18th International Symposium on Cells of the Hepatic Sinusoid  2015.10 

Inhibitory effect of bile acids on hepatic stellate cell activation International conference

Teranishi Y, Matsubara T, Odagiri N, Ikeda K, Kawada N.

18th International Symposium on Cells of the Hepatic Sinusoid  2015.10 

Characterization of senescence-associated hepatic stellate cells using human primary culture cells. Domestic conference

Odagiri N, Matsubara T, Kawada N, Ikeda K.

18th International Symposium on Cells of the Hepatic Sinusoid  2015.10 

アセトアミノフェン誘導性肝障害における小胞体ストレス応答因子CHOPの役割 Domestic conference

-

第28回肝類洞壁細胞研究会  2014.12 

ヒト肝星細胞におけるサイトグロビン遺伝子発現調節機構の分子解析 Domestic conference

-

第28回肝類洞壁細胞研究会  2014.12 

肝星細胞のエピジェネティクス制御機構 Domestic conference

-

第28回肝類洞壁細胞研究会  2014.12 

Hsp47欠損は肝星細胞で小胞体ストレス依存的なアポトーシスを引き起こす

川崎 邦人, 潮田 亮, 伊藤 進也, 池田 一雄, 真砂 有作, 永田 和宏

日本生化学会大会プログラム・講演要旨集  2014.10  (公社)日本生化学会

肝星細胞のサイトグロビンはアセトアミノフェンによる急性肝障害に関与する

寺西 優雅, 松原 勤, 池田 一雄, 河田 則文

肝臓  2014.04  (一社)日本肝臓学会

活性増強型Bcl-xL(FNK)過剰発現を利用したヒトiPS細胞由来肝細胞のマウス肝置換効率向上

長基 康人, 高山 和雄, 田代 克久, 立野 知世, 櫻井 文教, 立花 雅史, 川端 健二, 池田 一雄, 田中 靖人, 水口 裕之

日本薬学会年会要旨集  2014.03  (公社)日本薬学会

Stress influences on bile acid homeostasis in development of diet-induced steatohepatitis International conference

Matsubara T, Kitamura K, Tranishi Y, Kawada N, Ikeda K

64th Annual Meeting of the American Association for the Study of Liver Diseases   2013.10 

Stress accelerates derangement of bile acid homeostasis during development of steatohepatitis in mice International conference

Matsubara T, Kitamura K, Tranishi Y, Kawada N, Ikeda K

17th International Symposium on Cells of the Hepatic Sinusoid & 27th Annual Meeting for Hepatic Sinusoidal Research  2013.09 

慢性肝疾患における肝線維化バイオマーカーとしてのmiR-222の有用性

河田 則文, 小川 智弘, 榎本 大, 藤井 英樹, 村上 善基, 吉里 勝利, 池田 一雄

日本臨床分子医学会学術総会プログラム・抄録集  2013.04  日本臨床分子医学会

肝線維化の病態解明と治療への展開　慢性肝疾患における肝線維化診断マーカーとしてのマイクロRNAの有用性

河田 則文, 小川 智弘, 榎本 大, 吉里 勝利, 池田 一雄

肝臓  2012.04  (一社)日本肝臓学会

DENで誘導される肝癌と肺癌の発生はサイトグロビン欠損で促進される Domestic conference

Le Thi Thanh Thuy, 森田 隆, 吉田 佳世, 若狭 研一, 飯塚 昌司, 小川 智弘, 森 真美, 関谷 由美子, 木綿 しのぶ, 元山 宏行, 池田 一雄, 吉里 勝利, 河田 則文

大阪市医学会雑誌  2011.12  大阪市医学会

ヒトiPS細胞の肝細胞への分化誘導とiPS細胞由来肝細胞のマウス胎仔肝臓への移植方法の検討

杉山 良典, 立野 知世, 河田 則文, 池田 一雄

肝臓  2011.11  (一社)日本肝臓学会

肝線維化と星細胞活性化に関与するマイクロRNAの解析

飯塚 昌司, 小川 智弘, 関谷 由美子, 榎本 大, 吉里 勝利, 池田 一雄, 河田 則文

肝臓  2011.09  (一社)日本肝臓学会

miR-195の肝星細胞増殖における役割についての検討 Domestic conference

関谷 由美子, 小川 智弘, 飯塚 昌司, 吉里 勝利, 池田 一雄, 河田 則文

肝臓  2011.04  (一社)日本肝臓学会

I型インターフェロンのマイクロRNA発現調節を介した肝星細胞増殖抑制作用 Domestic conference

関谷 由美子, 小川 智弘, 飯塚 昌司, 吉里 勝利, 池田 一雄, 河田 則文

肝臓  2010.04  (一社)日本肝臓学会

マイクロRNAによる肝星細胞のI型コラーゲン発現制御

飯塚 昌司, 小川 智弘, 関谷 由美子, 吉里 勝利, 池田 一雄, 河田 則文

肝臓  2010.04  (一社)日本肝臓学会

ShRNAライブラリーを用いた肝線維化,癌化関連因子の網羅的解析と治療への応用

萌芽研究  2006.04

アデノウイルスベクターを用いた細胞特異的遺伝子制御による肝線維化治療の基礎研究

Grant-in-Aid for Scientific Research(C)  2004.04

コラーゲン刺激によるDDR2レセプターシグナル伝達およびその機能解析

Grant-in-Aid for Scientific Research(C)  2002.04

肝星細胞から肝実質細胞へのレチノイド移送

奨励研究(A)  1997.04

感覚器・皮膚コース

2019     Undergraduate

神経解剖コース

2019     Undergraduate