Updated on 2024/10/22

写真a

 
YASHIRO Masakazu
 
Organization
Graduate School of Medicine Department of Clinical Medical Science Associate Professor
School of Medicine Department of Medical Science
Title
Associate Professor
Affiliation
Institute of Medicine
Profile
1988 M.D. Osaka City University Medical School. 1995 Ph.D. Osaka City University. 1996-1997 Research Fellow, UCSD, School of Medicine. 1997-Present Department of Surgical Oncology. 2007-present Associate Professor Molecular Oncology and Therapeutics/

Position

  • Graduate School of Medicine Department of Clinical Medical Science 

    Associate Professor  2022.04 - Now

  • School of Medicine Department of Medical Science 

    Associate Professor  2022.04 - Now

Degree

  • Doctor of Medicine ( Others )

Research Areas

  • Life Science / Digestive surgery  / Gastroenterol Surgery

  • Life Science / Pathological biochemistry  / Oncology

  • Life Science / General surgery and pediatric surgery

  • Life Science / Digestive surgery

  • Life Science / General surgery and pediatric surgery

Research Interests

  • Cancer,Molecular biology, Targetting therapy

  • Oncology」

  • Gastroenterol Surgery

Research subject summary

  • We aim at the development of the novel molecular target therapy based on cancer molecular mechanism.

Research Career

Professional Memberships

  • AACR

      Overseas

  • 遺伝性腫瘍学会

      Domestic

  • 日本癌学会

  • 日本消化器外科学会

  • 日本乳癌学会

      Domestic

  • 日本外科学会

  • 日本消化器内視鏡学会

      Domestic

  • 日本消化器病学会

      Domestic

  • 日本大腸肛門病学会

      Domestic

  • 日本消化器癌発生学会

  • 日本胃癌学会

  • 米国癌学会

  • 日本胃癌学会

  • 日本癌学会

  • 日本消化器癌発生学会

  • 日本消化器病学会

  • 日本消化器外科学会

  • 日本消化器内視鏡学会

  • 日本大腸肛門病学会

  • 日本外科学会

  • 日本乳癌学会

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Awards

  • 日本消化器癌発生学会奨励賞

    2007  

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    Country:Japan

  • 日本消化器癌発生学会奨励賞

    2007  

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    Country:Japan

  • The SUBSIDY Award for Cancer Research (The 5th International Symposium on Cancer Research

    2006  

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    Country:Japan

  • 癌研究奨励賞

    2006  

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    Country:Japan

  • 平成18年度大阪市医学会市長賞

    2005  

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    Country:Japan

  • 平成18年度大阪市医学会市長賞

    2005  

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    Country:Japan

  • 大阪市医学会市長賞

    1998  

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    Country:Japan

  • 大阪市医学会市長賞

    1997  

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    Country:Japan

  • 国際胃癌学会ポスター賞(Poster Prize)

    1995  

  • 消化器癌発生研究会(Young Researchers Award)

    1995  

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    Country:Japan

  • 日本消化器外科学会研究者賞(Young Researchers Award)

    1993  

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    Country:Japan

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Job Career (off-campus)

  • 大阪市立住吉市民病院・研究医   研究医

    1990.06 - 1991.05

Education

  • Osaka City University   Doctor's Course  

    - 1995

  • Osaka City University    

    - 1988

Papers

  • Significance of Multi-Cancer Genome Profiling Testing for Breast Cancer: A Retrospective Analysis of 3326 Cases from Japan's National Database. Reviewed

    Kawabata K, Nishikubo H, Kanei S, Aoyama R, Tsukada Y, Sano T, Imanishi D, Sakuma T, Maruo K, Yamamoto Y, Wang Q, Zhu Z, Fan C, Yashiro M

    Genes   15 ( 6 )   2024.06

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.3390/genes15060792

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  • Clinical Characteristics of Cryopyrin-Associated Periodic Syndrome and Long-Term Real-World Efficacy and Tolerability of Canakinumab in Japan: Results of a Nationwide Survey Reviewed

    Miyamoto T.

    Arthritis and Rheumatology   76 ( 6 )   949 - 962   2024.06( ISSN:23265191

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/art.42808

  • Prognostic significance of connective tissue growth factor expression in stromal cells in patients with diffuse‑type gastric cancer. Reviewed

    Miki Y, Yoshii M, Miyauchi R, Kasashima H, Fukuoka T, Tamura T, Shibutani M, Toyokawa T, Lee S, Yashiro M, Maeda K

    Oncology letters   27 ( 6 )   241   2024.06( ISSN:1792-1074

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.3892/ol.2024.14374

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  • Bioinformatics Analysis and Validation of Potential Markers Associated with Prediction and Prognosis of Gastric Cancer. Reviewed

    Tasuku Matsuoka, Masakazu Yashiro

    International journal of molecular sciences   25 ( 11 )   2024.05( ISSN:16616596

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    Publishing type:Research paper (scientific journal)   International / domestic magazine:International journal  

    Gastric cancer (GC) is one of the most common cancers worldwide. Most patients are diagnosed at the progressive stage of the disease, and current anticancer drug advancements are still lacking. Therefore, it is crucial to find relevant biomarkers with the accurate prediction of prognoses and good predictive accuracy to select appropriate patients with GC. Recent advances in molecular profiling technologies, including genomics, epigenomics, transcriptomics, proteomics, and metabolomics, have enabled the approach of GC biology at multiple levels of omics interaction networks. Systemic biological analyses, such as computational inference of "big data" and advanced bioinformatic approaches, are emerging to identify the key molecular biomarkers of GC, which would benefit targeted therapies. This review summarizes the current status of how bioinformatics analysis contributes to biomarker discovery for prognosis and prediction of therapeutic efficacy in GC based on a search of the medical literature. We highlight emerging individual multi-omics datasets, such as genomics, epigenomics, transcriptomics, proteomics, and metabolomics, for validating putative markers. Finally, we discuss the current challenges and future perspectives to integrate multi-omics analysis for improving biomarker implementation. The practical integration of bioinformatics analysis and multi-omics datasets under complementary computational analysis is having a great impact on the search for predictive and prognostic biomarkers and may lead to an important revolution in treatment.

    DOI: 10.3390/ijms25115880

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  • Epithelial aPKC deficiency leads to stem cell loss preceding metaplasia in colorectal cancer initiation. Reviewed

    Kinoshita H, Martinez-Ordoñez A, Cid-Diaz T, Han Q, Duran A, Muta Y, Zhang X, Linares JF, Nakanishi Y, Kasashima H, Yashiro M, Maeda K, Albaladejo-Gonzalez A, Torres-Moreno D, García-Solano J, Conesa-Zamora P, Inghirami G, Diaz-Meco MT, Moscat J

    Developmental cell   2024.05( ISSN:1534-5807

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.devcel.2024.05.001

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  • Clinical practice guidelines for molecular tumor marker, 2nd edition review part 2. Reviewed

    Kikuchi Y, Shimada H, Yamasaki F, Yamashita T, Araki K, Horimoto K, Yajima S, Yashiro M, Yokoi K, Cho H, Ehira T, Nakahara K, Yasuda H, Isobe K, Hayashida T, Hatakeyama S, Akakura K, Aoki D, Nomura H, Tada Y, Yoshimatsu Y, Miyachi H, Takebayashi C, Hanamura I, Takahashi H

    International journal of clinical oncology   29 ( 5 )   512 - 534   2024.05( ISSN:1341-9625

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s10147-024-02497-0

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  • C-CAT's triumph in gastroenterology: the wisdom of cats is infinitely superior. Reviewed

    Enomoto M, Odagiri N, Rinka K, Maruyama H, Shimamoto Y, Ishikawa-Kakiya Y, Fujiwara Y, Kawada N, Yashiro M

    Journal of gastroenterology   59 ( 2 )   157 - 158   2024.02( ISSN:0944-1174

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00535-023-02061-z

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  • Exosomes secreted by ST3GAL5(high) cancer cells promote peritoneal dissemination by establishing a premetastatic microenvironment. Reviewed

    Horie M, Takagane K, Itoh G, Kuriyama S, Yanagihara K, Yashiro M, Umakoshi M, Goto A, Arita J, Tanaka M

    Molecular oncology   18 ( 1 )   21 - 43   2024.01( ISSN:1574-7891

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/1878-0261.13524

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  • Clinical Significance of Multi-Cancer Genome Profiling: Data from a Single Hospital in Japan. Reviewed

    Aoyama R, Nishikubo H, Kawabata K, Kanei S, Yamamoto Y, Nishimura S, Yashiro M

    Cancer genomics & proteomics   21 ( 1 )   79 - 87   2024.01( ISSN:1109-6535

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.21873/cgp.20431

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  • Suppressed pediatric asthma hospitalizations during the COVID-19 pandemic in Japan, from a national survey Reviewed

    Korematsu S.

    Clinical and Translational Allergy   14 ( 1 )   2024.01

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/clt2.12330

  • Current status and perspectives of genetic testing in gastrointestinal cancer (Review). Reviewed

    Matsuoka T, Yashiro M

    Oncology letters   27 ( 1 )   21   2024.01( ISSN:1792-1074

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.3892/ol.2023.14155

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  • Stromal area differences with epithelial-mesenchymal transition gene changes in conjunctival and orbital mucosa-associated lymphoid tissue lymphoma. Reviewed

    Tagami M, Kasashima H, Kakehashi A, Yoshikawa A, Nishio M, Misawa N, Sakai A, Wanibuchi H, Yashiro M, Azumi A, Honda S

    Frontiers in oncology   14   1277749   2024( ISSN:2234-943X

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.3389/fonc.2024.1277749

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  • Two families with gastric adenocarcinoma and proximal polyposis of the stomach (GAPPS): case reports and literature review. Reviewed

    Sakuma T, Sera T, Aoyama R, Sawada A, Kasashima H, Ogisawa K, Bamba H, Yashiro M

    Journal of gastrointestinal oncology   14 ( 6 )   2650 - 2657   2023.12( ISSN:2078-6891

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.21037/jgo-23-564

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  • Molecular Insight into Gastric Cancer Invasion-Current Status and Future Directions. Reviewed

    Matsuoka T, Yashiro M

    Cancers   16 ( 1 )   2023.12( ISSN:2072-6694

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.3390/cancers16010054

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  • Enhanced SREBP2-driven cholesterol biosynthesis by PKCλ/ι deficiency in intestinal epithelial cells promotes aggressive serrated tumorigenesis. Reviewed

    Muta Y, Linares JF, Martinez-Ordoñez A, Duran A, Cid-Diaz T, Kinoshita H, Zhang X, Han Q, Nakanishi Y, Nakanishi N, Cordes T, Arora GK, Ruiz-Martinez M, Reina-Campos M, Kasashima H, Yashiro M, Maeda K, Albaladejo-Gonzalez A, Torres-Moreno D, García-Solano J, Conesa-Zamora P, Inghirami G, Metallo CM, Osborne TF, Diaz-Meco MT, Moscat J

    Nature communications   14 ( 1 )   8075   2023.12

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41467-023-43690-5

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  • The Role of the Transforming Growth Factor-β Signaling Pathway in Gastrointestinal Cancers. Reviewed

    Matsuoka T, Yashiro M

    Biomolecules   13 ( 10 )   2023.10

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.3390/biom13101551

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  • Impact of SMAD2 and MET Expression on Lymph Node Metastasis of HER2-positive Gastric Cancer Cells. Reviewed

    Tsujio G, Yashiro M, Sakuma T, Aoyama R, Maruo K, Yamamoto Y, Maeda K

    Anticancer research   43 ( 10 )   4359 - 4364   2023.10( ISSN:0250-7005

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.21873/anticanres.16631

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  • RBM17 Expression Is Associated With the Efficacy of ICI Monotherapy in NSCLC With Low PD-L1 Expression. Reviewed

    Nagamine H, Yashiro M, Yoshimoto N, Izumi M, Sugimoto A, Nakahama K, Ogawa K, Matsumoto Y, Sawa K, Tani Y, Kaneda H, Mitsuoka S, Yamada K, Watanabe T, Aasai K, Fukumura K, Mayeda A, Kawaguchi T

    Anticancer research   43 ( 10 )   4663 - 4672   2023.10( ISSN:0250-7005

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.21873/anticanres.16662

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  • THBS1-producing tumor-infiltrating monocyte-like cells contribute to immunosuppression and metastasis in colorectal cancer Reviewed

    Omatsu Mayuki, Nakanishi Yuki, Iwane Kosuke, Aoyama Naoki, Duran Angeles, Muta Yu, Martinez-Ordoñez Anxo, Han Qixiu, Agatsuma Nobukazu, Mizukoshi Kenta, Kawai Munenori, Yamakawa Go, Namikawa Mio, Hamada Kensuke, Fukunaga Yuichi, Utsumi Takahiro, Sono Makoto, Masuda Tomonori, Hata Akitaka, Araki Osamu, Nagao Munemasa, Yoshikawa Takaaki, Ogawa Satoshi, Hiramatsu Yukiko, Tsuda Motoyuki, Maruno Takahisa, Kogame Toshiaki, Kasashima Hiroaki, Kakiuchi Nobuyuki, Nakagawa Masahiro M., Kawada Kenji, Yashiro Masakazu, Maeda Kiyoshi, Saito Yasuyuki, Matozaki Takashi, Fukuda Akihisa, Kabashima Kenji, Obama Kazutaka, Ogawa Seishi, Sheibani Nader, Diaz-Meco Maria T., Moscat Jorge, Seno Hiroshi

    Nature Communications   14   2023.09( eISSN:20411723

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    Mesenchymal activation, characterized by dense stromal infiltration of immune and mesenchymal cells, fuels the aggressiveness of colorectal cancers (CRC), driving progression and metastasis. Targetable molecules in the tumor microenvironment (TME) need to be identified to improve the outcome in CRC patients with this aggressive phenotype. This study reports a positive link between high thrombospondin-1 (THBS1) expression and mesenchymal characteristics, immunosuppression, and unfavorable CRC prognosis. Bone marrow-derived monocyte-like cells recruited by CXCL12 are the primary source of THBS1, which contributes to the development of metastasis by inducing cytotoxic T-cell exhaustion and impairing vascularization. Furthermore, in orthotopically generated CRC models in male mice, THBS1 loss in the TME renders tumors partially sensitive to immune checkpoint inhibitors and anti-cancer drugs. Our study establishes THBS1 as a potential biomarker for identifying mesenchymal CRC and as a critical suppressor of antitumor immunity that contributes to the progression of this malignancy with a poor prognosis.

  • THBS1-producing tumor-infiltrating monocyte-like cells contribute to immunosuppression and metastasis in colorectal cancer. Reviewed

    Omatsu M, Nakanishi Y, Iwane K, Aoyama N, Duran A, Muta Y, Martinez-Ordoñez A, Han Q, Agatsuma N, Mizukoshi K, Kawai M, Yamakawa G, Namikawa M, Hamada K, Fukunaga Y, Utsumi T, Sono M, Masuda T, Hata A, Araki O, Nagao M, Yoshikawa T, Ogawa S, Hiramatsu Y, Tsuda M, Maruno T, Kogame T, Kasashima H, Kakiuchi N, Nakagawa MM, Kawada K, Yashiro M, Maeda K, Saito Y, Matozaki T, Fukuda A, Kabashima K, Obama K, Ogawa S, Sheibani N, Diaz-Meco MT, Moscat J, Seno H

    Nature communications   14 ( 1 )   5534   2023.09

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41467-023-41095-y

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  • [The Role of Cancer-Associated Fibroblasts in Modulating Tumor Immunity in Colorectal Cancer]. Reviewed

    Kasashima H, Fukui Y, Kitayama K, Miki Y, Yoshii M, Fukuoka T, Tamura T, Shibutani M, Toyokawa T, Ree S, Tanaka H, Yashiro M, Maeda K

    Gan to kagaku ryoho. Cancer & chemotherapy   50 ( 9 )   958 - 959   2023.09( ISSN:0385-0684

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  • 大腸癌微小環境における抗原提示性癌関連線維芽細胞が腫瘍進展に及ぼす影響の解析(The effect of antigen-presenting cancer-associated fibroblast in TME for tumor progression of colon cancer) Reviewed

    笠島 裕明, 福井 康裕, 中西 祐貴, 北山 紀州, 三木 友一朗, 吉井 真美, 福岡 達成, 田村 達郎, 渋谷 雅常, 豊川 貴弘, 田中 浩明, 李 栄柱, 八代 正和, 前田 清

    日本癌学会総会記事   82回   838 - 838   2023.09( ISSN:0546-0476

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  • Trophoblast cell surface antigen-2 phosphorylation triggered by binding of galectin-3 drives metastasis through down-regulation of E-cadherin. Reviewed

    Iwamoto S, Mori Y, Yamashita T, Ojima K, Akita K, Togano S, Kushiyama S, Yashiro M, Yatera Y, Yamaguchi T, Komiyama A, Sago Y, Itano N, Nakada H

    The Journal of biological chemistry   299 ( 8 )   104971   2023.08( ISSN:0021-9258

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.jbc.2023.104971

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  • Novel biomarkers for early detection of gastric cancer. Reviewed

    Matsuoka T, Yashiro M

    World journal of gastroenterology   29 ( 17 )   2515 - 2533   2023.05( ISSN:1007-9327

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.3748/wjg.v29.i17.2515

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  • Establishment of a gastric cancer cell line with high microsatellite instability, OCUM-13, derived from Borrmann type-2 primary tumor. Reviewed

    Yamamoto Y, Masuda G, Kushiyama S, Maruo K, Tsujio G, Sera T, Sugimoto A, Nishimura S, Kuroda K, Togano S, Okuno T, Ohira M, Yashiro M

    Cancer medicine   12 ( 5 )   6016 - 6022   2023.03

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/cam4.5403

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  • IL-1β derived from mixed-polarized macrophages activates fibroblasts and synergistically forms a cancer-promoting microenvironment. Reviewed

    Zhang J, Fu L, Yasuda-Yoshihara N, Yonemura A, Wei F, Bu L, Hu X, Akiyama T, Kitamura F, Yasuda T, Semba T, Uchihara T, Itoyama R, Yamashita K, Eto K, Iwagami S, Yashiro M, Komohara Y, Baba H, Ishimoto T

    Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association   26 ( 2 )   187 - 202   2023.03( ISSN:1436-3291

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s10120-022-01352-3

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  • GLUT1 and PKM2 may be useful prognostic predictors in patients with non‑small cell lung cancer following curative R0 resection. Reviewed

    Ito R, Yashiro M, Tsukioka T, Izumi N, Komatsu H, Inoue H, Yamamoto Y, Nishiyama N

    Oncology letters   25 ( 3 )   129   2023.03( ISSN:1792-1074

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.3892/ol.2023.13715

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  • 混合分極化マクロファージ由来のIL-1βは線維芽細胞を活性化し、相乗的に癌促進性微小環境を形成する(IL-1β derived from mixed-polarized macrophages activates fibroblasts and synergistically forms a cancer-promoting microenvironment) Reviewed

    Zhang Jun, Fu Lingfeng, Yasuda-Yoshihara Noriko, Yonemura Atsuko, Wei Feng, Bu Luke, Hu Xichen, Akiyama Takahiko, Kitamura Fumimasa, Yasuda Tadahito, Semba Takashi, Uchihara Tomoyuki, Itoyama Rumi, Yamashita Kohei, Eto Kojiro, Iwagami Shiro, Yashiro Masakazu, Komohara Yoshihiro, Baba Hideo, Ishimoto Takatsugu

    Gastric Cancer   26 ( 2 )   187 - 202   2023.03( ISSN:1436-3291

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    びまん型胃癌(DGC)進行における腫瘍微小環境でのマクロファージ、線維芽細胞、DGC細胞の相互活性化メカニズムについて検討した。マクロファージ、非癌性線維芽細胞(NF)、DGC細胞を共培養し、マスサイトメトリー分析を実施した。NFとマクロファージはDGC細胞と相互作用し、DGC組織の浸潤先進部に細胞クラスターを形成した。共培養下でM1/M2型細胞表面マーカーを有する混合分極化マクロファージを認めた。混合分極化マクロファージが産生したIL-1βは、NFの癌関連線維芽細胞様細胞変換を誘導し、IL-6やIL-24、白血病阻害因子の分泌が増加し、DGC細胞の悪性表現型を促進した。混合分極化マクロファージの安定性はIL-6とGM-CSFにより維持されていた。混合極性化マクロファージはDGC組織で多く検出された。

  • Hyaluronan driven by epithelial aPKC deficiency remodels the microenvironment and creates a vulnerability in mesenchymal colorectal cancer. Reviewed

    Martinez-Ordoñez A, Duran A, Ruiz-Martinez M, Cid-Diaz T, Zhang X, Han Q, Kinoshita H, Muta Y, Linares JF, Kasashima H, Nakanishi Y, Omar M, Nishimura S, Avila L, Yashiro M, Maeda K, Pannellini T, Pigazzi A, Inghirami G, Marchionni L, Sigal D, Diaz-Meco MT, Moscat J

    Cancer cell   41 ( 2 )   252 - 271.e9   2023.02( ISSN:1535-6108

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.ccell.2022.11.016

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  • Usefulness of pyruvate dehydrogenase-E1α expression to determine SUVmax cut-off value of [(18)F]FDG-PET for predicting lymph node metastasis in lung cancer. Reviewed

    Ito R, Yashiro M, Tsukioka T, Izumi N, Komatsu H, Inoue H, Nishiyama N

    Scientific reports   13 ( 1 )   1565   2023.01

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41598-023-28805-8

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  • CD9-positive Exosomes Derived from Cancer-associated Fibroblasts Might Inhibit the Proliferation of Malignant Melanoma Cells. Reviewed

    Fujii N, Yashiro M, Hatano T, Fujikawa H, Motomura H

    Anticancer research   43 ( 1 )   25 - 33   2023.01( ISSN:0250-7005

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.21873/anticanres.16130

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  • The heterogeneity of cancer-associated fibroblast subpopulations: Their origins, biomarkers, and roles in the tumor microenvironment. Reviewed

    Yamamoto Y, Kasashima H, Fukui Y, Tsujio G, Yashiro M, Maeda K

    Cancer science   114 ( 1 )   16 - 24   2023.01( ISSN:1347-9032

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/cas.15609

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  • CCDC85A is regulated by miR-224-3p and augments cancer cell resistance to endoplasmic reticulum stress. Reviewed

    Takahashi S, Takagane K, Itoh G, Kuriyama S, Umakoshi M, Goto A, Yanagihara K, Yashiro M, Iijima K, Tanaka M

    Frontiers in oncology   13   1196546   2023( ISSN:2234-943X

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.3389/fonc.2023.1196546

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  • Tumor-infiltrating lymphocytes and macrophages as a significant prognostic factor in biliary tract cancer. Reviewed

    Tanaka R, Eguchi S, Kimura K, Ohira G, Tanaka S, Amano R, Tanaka H, Yashiro M, Ohira M, Kubo S

    PloS one   18 ( 1 )   e0280348   2023

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1371/journal.pone.0280348

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  • The Cancer Cachexia Index Can Be Used to Prognostically Predict Patients with Gastric Cancer Undergoing Gastrectomy. Reviewed

    Sakurai K, Kubo N, Hasegawa T, Nishimura J, Iseki Y, Nishii T, Inoue T, Yashiro M, Nishiguchi Y, Maeda K

    Annals of nutrition & metabolism   79 ( 6 )   511 - 521   2023( ISSN:0250-6807

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1159/000534244

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  • The safe removal of a superior mediastinal foreign body by mediastinoscopy: a case report. Reviewed

    Sakuma T, Tamura T, Nambara M, Gyobu K, Yoshii M, Toyokawa T, Lee S, Tanaka H, Muguruma K, Yashiro M, Ohira M, Maeda K

    Surgical case reports   8 ( 1 )   174   2022.09( ISSN:2198-7793

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s40792-022-01525-3

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  • Lipocalin-2 negatively regulates epithelial-mesenchymal transition through matrix metalloprotease-2 downregulation in gastric cancer. Reviewed

    Nishimura S, Yamamoto Y, Sugimoto A, Kushiyama S, Togano S, Kuroda K, Okuno T, Kasashima H, Ohira M, Maeda K, Yashiro M

    Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association   25 ( 5 )   850 - 861   2022.09( ISSN:1436-3291

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    DOI: 10.1007/s10120-022-01305-w

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  • リポカリン-2は胃癌におけるマトリックスメタロプロテアーゼ-2の発現抑制を通じて上皮間葉転換を負に調節する(Lipocalin-2 negatively regulates epithelial-mesenchymal transition through matrix metalloprotease-2 downregulation in gastric cancer) Reviewed

    Nishimura Sadaaki, Yamamoto Yurie, Sugimoto Atsushi, Kushiyama Shuhei, Togano Shingo, Kuroda Kenji, Okuno Tomohisa, Kasashima Hiroaki, Ohira Masaichi, Maeda Kiyoshi, Yashiro Masakazu

    Gastric Cancer   25 ( 5 )   850 - 861   2022.09( ISSN:1436-3291

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    リポカリン-2(LCN2)は生体内で炎症反応の調節や抗菌作用など多様な機能を有する分泌性糖タンパク質である。本研究では、LCN2の胃癌における関与とそのメカニズムを検討した。LCN2は、拡散型胃癌と上皮間葉転換型胃癌で発現が低下していた。LCN2の発現抑制は、胃癌細胞の増殖、浸潤、遊走を有意に促進した。その分子メカニズムとして、LCN2の発現抑制は、胃癌細胞におけるEMTシグナルを促進するマトリックスメタロプロテイナーゼ-2(MMP2)刺激に寄与していた。GSEA(gene set enrichment analysis)の発現解析より、ヒト試料におけるLCN2の発現抑制がEMTシグナルに関与していた。LCN2タンパク質およびmRNAの低レベルは、胃癌患者の予後不良と有意に関連しており、LCN2 mRNAレベルは患者の全生存に対する独立した予後因子であった。以上より、LCN2は、胃癌の進行においてMMP2活性を介したEMTシグナルに重要な役割を担っていた。

  • 縦隔鏡を用いて行った上縦隔の異物の安全な除去 症例報告(The safe removal of a superior mediastinal foreign body by mediastinoscopy: a case report) Reviewed

    Sakuma Takashi, Tamura Tatsuro, Nambara Mikio, Gyobu Ken, Yoshii Mami, Toyokawa Takahiro, Lee Shigeru, Tanaka Hiroaki, Muguruma Kazuya, Yashiro Masakazu, Ohira Masaichi, Maeda Kiyoshi

    Surgical Case Reports   8   1 of 5 - 5 of 5   2022.09

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    症例は74歳男性。庭で剪定作業を行っている際に梯子から転落し、アザレアの枝が左側の胸鎖乳突筋に刺さる事故を起こした。直ちに近医へ搬送され、当日のうちにその除去手術を受けた。以後は無症状であったが、4ヵ月後に嗄声を自覚し始めたため再受診した。精査の結果、刺さった枝が残存していることが疑われたため、上縦隔内の異物の外科的管理を目的に当科へ紹介された。上部消化管内視鏡検査では胸部上部食道の前壁に隆起病変を認め、造影CTでは上縦隔の気管と食道の間に当たる位置に直線形状で約10×45mm大の異物が描出された。異物除去手術を実施し、圧を5~8cmH2Oかける気縦隔下でビデオ縦隔鏡を挿入した。その結果、広い術視野が得られ、瘢痕組織を切開して4cm長のアザレアの枝を注意深く安全に除去することに成功した。処置中に他の縦隔臓器を損傷することは無かった。手術時間は166分、出血量は45mlであった。手術から5日目に合併症のみられない状態で退院した。以降、4ヵ月毎に行った経過観察では創傷治癒が良好であることが確認されたが患者は嗄声を依然として自覚しており、そのため音声リハビリテーションが実施された。

  • Interleukin-8 produced from cancer-associated fibroblasts suppresses proliferation of the OCUCh-LM1 cancer cell line. Reviewed

    Tanaka R, Kimura K, Eguchi S, Ohira G, Tanaka S, Amano R, Tanaka H, Yashiro M, Ohira M, Kubo S

    BMC cancer   22 ( 1 )   748   2022.07

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    DOI: 10.1186/s12885-022-09847-z

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  • Significance of tumor heterogeneity of p-Smad2 and c-Met in HER2-positive gastric carcinoma with lymph node metastasis. Reviewed

    Tsujio G, Maruo K, Yamamoto Y, Sera T, Sugimoto A, Kasashima H, Miki Y, Yoshii M, Tamura T, Toyokawa T, Tanaka H, Muguruma K, Ohira M, Yashiro M

    BMC cancer   22 ( 1 )   598   2022.06

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    DOI: 10.1186/s12885-022-09681-3

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  • Optimal Organ for Patient-derived Xenograft Model in Pancreatic Cancer and Microenvironment that Contributes to Success. Reviewed

    Eguchi S, Kimura K, Kageyama K, Tani N, Tanaka R, Nishio K, Shinkawa H, Ohira GO, Amano R, Tanaka S, Yamamoto A, Takemura S, Yashiro M, Kubo S

    Anticancer research   42 ( 5 )   2395 - 2404   2022.05( ISSN:0250-7005

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    DOI: 10.21873/anticanres.15718

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  • Transferrin receptor 1 promotes the fibroblast growth factor receptor-mediated oncogenic potential of diffused-type gastric cancer. Reviewed

    Shirakihara T, Yamaguchi H, Kondo T, Yashiro M, Sakai R

    Oncogene   41 ( 18 )   2587 - 2596   2022.04( ISSN:0950-9232

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    DOI: 10.1038/s41388-022-02270-5

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  • Prognostic impact of postoperative systemic inflammatory response in patients with stage II/III gastric cancer. Reviewed

    Kuroda K, Toyokawa T, Miki Y, Yoshii M, Tamura T, Tanaka H, Lee S, Muguruma K, Yashiro M, Ohira M

    Scientific reports   12 ( 1 )   3025   2022.02

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    DOI: 10.1038/s41598-022-07098-3

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  • Integrin α5 mediates cancer cell-fibroblast adhesion and peritoneal dissemination of diffuse-type gastric carcinoma. Reviewed

    Miyamoto S, Nagano Y, Miyazaki M, Nagamura Y, Sasaki K, Kawamura T, Yanagihara K, Imai T, Ohki R, Yashiro M, Tanaka M, Sakai R, Yamaguchi H

    Cancer letters   526   335 - 345   2022.02( ISSN:0304-3835

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    DOI: 10.1016/j.canlet.2021.11.008

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  • Cancer-associated fibroblasts educate normal fibroblasts to facilitate cancer cell spreading and T-cell suppression. Reviewed

    Itoh G, Takagane K, Fukushi Y, Kuriyama S, Umakoshi M, Goto A, Yanagihara K, Yashiro M, Tanaka M

    Molecular oncology   16 ( 1 )   166 - 187   2022.01( ISSN:1574-7891

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    DOI: 10.1002/1878-0261.13077

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  • Dipeptidyl Peptidase-4 from Cancer-associated Fibroblasts Stimulates the Proliferation of Scirrhous-type Gastric Cancer Cells. Reviewed

    Kushiyama S, Yashiro M, Yamamoto Y, Sera T, Sugimoto A, Nishimura S, Togano S, Kuroda K, Okuno T, Miki Y, Ohira M

    Anticancer research   42 ( 1 )   501 - 509   2022.01( ISSN:0250-7005

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    DOI: 10.21873/anticanres.15508

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  • CXCL1 might be a useful predictive prognostic marker in patients with gastric cancer Reviewed

    Yamamoto Yurie, Maruo Koji, Tsujio Gen, Sera Tomohiro, Sugimoto Atsushi, Kushiyama Syuhei, Nishimura Sadaaki, Kasashima Hiroaki, Yoshii Mami, Tamura Tatsuro, Toyokawa Takahiro, Tanaka Hiroaki, Muguruma Kazuya, Ohira Masaichi, Yashiro Masakazu

    Japan Journal of Molecular Tumor Marker Research   37 ( 0 )   29 - 30   2022( eISSN:24338575

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    DOI: 10.11241/jsmtmr.37.29

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  • Analysis of Protein and Gene Expression in Gastric Cancers Related to Lymph Node Metastasis and Prognosis with Clustering Analysis Reviewed

    Tsujio Gen, Maruo Koji, Yamamoto Yurie, Sera Tomohiro, Sugimoto Atsushi, Kasashima Hiroaki, Miki Yuichiro, Yoshii Mami, Tamura Tatsuro, Toyokawa Takahiro, Tanaka Hiroaki, Muguruma Kazuya, Ohira Masaichi, Yashiro Masakazu

    Japan Journal of Molecular Tumor Marker Research   38 ( 0 )   33 - 33   2022( eISSN:24338575

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    DOI: 10.11241/jsmtmr.38.33

  • Identification of Characteristic Genes of Scirrhous-type Gastric Cancer Cells By RNA-Seq Reviewed

    Sera Tomohiro, Maruo Koji, Tsujio Gen, Yamamoto Yurie, Sugimoto Atsushi, Kushiyama Syuhei, Togano Shingo, Kuroda Kenji, Kasashima Hiroaki, Yashiro Masakazu

    Japan Journal of Molecular Tumor Marker Research   37 ( 0 )   21 - 22   2022( eISSN:24338575

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    DOI: 10.11241/jsmtmr.37.21

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  • CXCR2 signaling might have a tumor-suppressive role in patients with cholangiocarcinoma. Reviewed

    Yamamoto Y, Sugimoto A, Maruo K, Tsujio G, Sera T, Kushiyama S, Nishimura S, Kuroda K, Togano S, Eguchi S, Tanaka R, Kimura K, Amano R, Ohira M, Yashiro M

    PloS one   17 ( 4 )   e0266027   2022

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    DOI: 10.1371/journal.pone.0266027

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  • Search for driver gene of scirrhous-type gastric cancer by RNA-seq using Next-Generation Sequencer Reviewed

    Sera Tomohiro, Aoyama Rika, Sakuma Takashi, Maruo Koji, Tsujio Gen, Yamamoto Yurie, Sugimoto Atsushi, Kushiyama Shuhei, Togano Shingo, Kuroda Kenji, Kasashima Hiroaki, Yashiro Masakazu

    Japan Journal of Molecular Tumor Marker Research   38 ( 0 )   46 - 46   2022( eISSN:24338575

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    DOI: 10.11241/jsmtmr.38.46

  • Clinical significance of the cancer gene panel Reviewed

    Aoyama Rika, Sakuma Takashi, Maruo Koji, Yamamoto Yurie, Sera Tomohiro, Tsujio Gen, Yashiro Masakazu

    Japan Journal of Molecular Tumor Marker Research   38 ( 0 )   16 - 16   2022( eISSN:24338575

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    DOI: 10.11241/jsmtmr.38.16

  • Intratumoral Heterogeneity of Protein and Gene Level in Gastric Cancer Reviewed

    Tsujio Gen, Maruo Koji, Yamamoto Yurie, Sera Tomohiro, Sugimoto Atsushi, Kushiyama Syuhei, Nishimura Sadaaki, Yoshii Mami, Tamura Tatsuro, Toyokawa Takahiro, Tanaka Hiroaki, Muguruma Kazuya, Kasashima Hiroaki, Yashiro Masakazu

    Japan Journal of Molecular Tumor Marker Research   37 ( 0 )   31 - 31   2022( eISSN:24338575

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    DOI: 10.11241/jsmtmr.37.31

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  • [Effect of Upfront Dose Reduction in the First Cycle of Chemotherapy for Unresectable/Recurrent Gastric Cancers in Patients Aged Over 80 Years]. Reviewed

    Sera T, Tamura T, Tanaka H, Kusunoki Y, Tsujio G, Okazaki Y, Sugimoto A, Miki Y, Yoshii M, Toyokawa T, Muguruma K, Yashiro M, Ohira M

    Gan to kagaku ryoho. Cancer & chemotherapy   48 ( 13 )   1619 - 1621   2021.12( ISSN:0385-0684

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  • [A Case of Hyperammonemic Encephalopathy following mFOLFOX6 plus Panitumumab Therapy for Rectal Cancer]. Reviewed

    Tsujio G, Muguruma K, Eguchi S, Iseki Y, Miki Y, Yoshii M, Fukuoka T, Tamura T, Shibutani M, Nagahara H, Toyokawa T, Tanaka H, Lee S, Yashiro M, Ohira M

    Gan to kagaku ryoho. Cancer & chemotherapy   48 ( 13 )   2073 - 2075   2021.12( ISSN:0385-0684

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  • 80歳以上の切除不能進行・再発胃癌に対する化学療法初回減量の経験 Reviewed

    瀬良 知央, 田村 達郎, 田中 浩明, 楠 由希奈, 辻尾 元, 岡崎 由季, 杉本 敦史, 三木 友一朗, 吉井 真美, 豊川 貴弘, 六車 一哉, 八代 正和, 大平 雅一

    癌と化学療法   48 ( 13 )   1619 - 1621   2021.12( ISSN:0385-0684

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    高齢患者を対象とした化学療法はリスクが高く、治療マネジメントに工夫が必要である。今回われわれは、80歳以上の切除不能進行・再発胃癌患者に対する化学療法の初回減量効果について検討した。2020年1月~2021年1月の間に教室にて80歳以上の切除不能進行・再発胃癌患者にS-1+L-OHP療法(SOX)を施行した6例を対象とした。初回減量群(U群:4例)のうちGrade 3以上の有害事象を来した症例は認めなかったが、通常量群(N群:2例)では1例に認めた。U群では全例が4コース以上を継続し得たが、N群は2例とも1コースで終了となっていた。治療効果としてPRを得たのは3例であり、すべてU群であった。second-lineに移行した症例はU群/N群=2例/0例であり、second-line治療を行った2例ともthird-lineまで移行し得た。80歳以上の高齢患者でも初回より減量することで有害事象の発生率を低減でき、長期の化学療法の継続が可能となることが示唆された。(著者抄録)

  • mFOLFOX6+Panitumumab療法中に高アンモニア血症を来した直腸癌の1例 Reviewed

    辻尾 元, 六車 一哉, 江口 真平, 井関 康仁, 三木 友一朗, 吉井 真美, 福岡 達成, 田村 達郎, 渋谷 雅常, 永原 央, 豊川 貴弘, 田中 浩明, 李 栄柱, 八代 正和, 大平 雅一

    癌と化学療法   48 ( 13 )   2073 - 2075   2021.12( ISSN:0385-0684

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    症例は80歳、男性。直腸S状部癌および腹膜播種に対し腹腔鏡下直腸高位前方切除術を施行した。直腸S状部癌、muc、pT4a、N3(14/15)、M1c、P1、pStage IVc、RAS/BRAF野生型の診断にて、入院の上mFOLFOX6+panitumumab(Pmab)療法を開始した。化学療法開始時の血液検査ではCr 1.45mg/dLと軽度腎機能障害を認めた。化学療法開始3日目朝より徐々に意識レベルの低下を認めた(JCSIII-200)。血液検査にて血漿アンモニア濃度338μg/dLと高値を認め、5-FUに伴う高アンモニア血症と診断し、5-FU持続静注の中止および分枝鎖アミノ酸製剤の投与を行った。意識レベルは翌朝には改善を認め、血漿アンモニア濃度も78μg/dLまで低下し、その後も意識障害は認めず退院となった。second-lineとしてCPT-11+Pmab療法へ変更し化学療法を開始したが、患者希望に1コースで投与終了とし化学療法を終了とした。今回われわれは、5-FUに起因する高アンモニア血症というまれな症例を経験したため若干の文献的考察を加えて報告する。(著者抄録)

  • PKCλ/ι inhibition activates an ULK2-mediated interferon response to repress tumorigenesis. Reviewed

    Linares JF, Zhang X, Martinez-Ordoñez A, Duran A, Kinoshita H, Kasashima H, Nakanishi N, Nakanishi Y, Carelli R, Cappelli L, Arias E, Yashiro M, Ohira M, Patel S, Inghirami G, Loda M, Cuervo AM, Diaz-Meco MT, Moscat J

    Molecular cell   81 ( 21 )   4509 - 4526.e10   2021.11( ISSN:1097-2765

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    DOI: 10.1016/j.molcel.2021.08.039

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  • Telmisartan Exerts Cytotoxicity in Scirrhous Gastric Cancer Cells by Inducing G(0)/G(1) Cell Cycle Arrest. Reviewed

    Tsujiya Y, Yamamori M, Hasegawa AI, Yamamoto Y, Yashiro M, Okamura N

    Anticancer research   41 ( 11 )   5461 - 5468   2021.11( ISSN:0250-7005

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    DOI: 10.21873/anticanres.15358

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  • Gastric cancer stem cells survive in stress environments via their autophagy system. Reviewed

    Togano S, Yashiro M, Masuda G, Sugimoto A, Miki Y, Yamamoto Y, Sera T, Kushiyama S, Nishimura S, Kuroda K, Okuno T, Ohira M

    Scientific reports   11 ( 1 )   20664   2021.10

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    DOI: 10.1038/s41598-021-00155-3

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  • Pyruvate dehydrogenase E1α represents a reliable prognostic predictor for patients with non-small cell lung cancer resected via curative operation. Reviewed

    Ito R, Yashiro M, Tsukioka T, Izumi N, Komatsu H, Inoue H, Yamamoto Y, Nishiyama N

    Journal of thoracic disease   13 ( 10 )   5691 - 5700   2021.10( ISSN:2072-1439

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    DOI: 10.21037/jtd-21-1463

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  • Preoperative C-reactive protein to albumin ratio predicts anastomotic leakage after esophagectomy for thoracic esophageal cancer: a single-center retrospective cohort study. Reviewed

    Sugimoto A, Toyokawa T, Miki Y, Yoshii M, Tamura T, Sakurai K, Kubo N, Tanaka H, Lee S, Muguruma K, Yashiro M, Ohira M

    BMC surgery   21 ( 1 )   348   2021.09

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    DOI: 10.1186/s12893-021-01344-7

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  • Asporinによる癌細胞の代謝リプログラムは酸化ストレス抵抗性を獲得させる Reviewed

    田中 正光, 高金 くらら, 伊藤 剛, 栗山 正, 山田 聡, 八代 正和

    日本癌学会総会記事   80回   [J8 - 4]   2021.09( ISSN:0546-0476

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  • オルガノイドが駆動するがん研究 PKCζ欠失により誘導されるSOX2-SFRP1/2陽性癌関連線維芽細胞集団の同定と機能解析 Reviewed

    笠島 裕明, Moscat Jorge, Diazmeco Maria T., 中西 祐貴, 工藤 洋太郎, 八代 正和, 大平 雅一

    日本癌学会総会記事   80回   [CS4 - 6]   2021.09( ISSN:0546-0476

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  • オルガノイドが駆動するがん研究 PKCζ欠失により誘導されるSOX2-SFRP1/2陽性癌関連線維芽細胞集団の同定と機能解析 Reviewed

    笠島 裕明, Moscat Jorge, Diazmeco Maria T., 中西 祐貴, 工藤 洋太郎, 八代 正和, 大平 雅一

    日本癌学会総会記事   80回   [CS4 - 6]   2021.09( ISSN:0546-0476

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  • EMMPRIN in extracellular vesicles from peritoneal mesothelial cells stimulates the invasion activity of diffuse-type gastric cancer cells. Reviewed

    Sugimoto A, Okuno T, Miki Y, Tsujio G, Sera T, Yamamoto Y, Kushiyama S, Nishimura S, Kuroda K, Togano S, Maruo K, Kasashima H, Ohira M, Yashiro M

    Cancer letters   521   169 - 177   2021.08( ISSN:0304-3835

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    DOI: 10.1016/j.canlet.2021.08.031

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  • Cancer-associated Fibroblast-derived Spondin-2 Promotes Motility of Gastric Cancer Cells. Reviewed

    Kuramitsu S, Masuda T, Hu Q, Tobo T, Yashiro M, Fujii A, Kitagawa A, Abe T, Otsu H, Ito S, Oki E, Mori M, Mimori K

    Cancer genomics & proteomics   18 ( 4 )   521 - 529   2021.07( ISSN:1109-6535

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    DOI: 10.21873/cgp.20277

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  • The duration of systemic inflammatory response syndrome is a reliable indicator of long-term survival after curative esophagectomy for esophageal squamous cell carcinoma. Reviewed

    Kubo N, Sakurai K, Tamura T, Toyokawa T, Tanaka H, Muguruma K, Yashiro M, Maeda K, Ohira M

    Esophagus : official journal of the Japan Esophageal Society   18 ( 3 )   548 - 558   2021.07( ISSN:1612-9059

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    DOI: 10.1007/s10388-021-00821-5

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  • 全身性炎症反応症候群の期間は、食道扁平上皮癌に対する根治的食道切除後の長期生存に関連する信頼し得る因子である(The duration of systemic inflammatory response syndrome is a reliable indicator of long-term survival after curative esophagectomy for esophageal squamous cell carcinoma) Reviewed

    Kubo Naoshi, Sakurai Katsunobu, Tamura Tatsuro, Toyokawa Takahiro, Tanaka Hiroaki, Muguruma Kazuya, Yashiro Masakazu, Maeda Kiyoshi, Ohira Masaichi

    Esophagus   18 ( 3 )   548 - 558   2021.07( ISSN:1612-9059

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    2005年から2015年の間に局在性食道扁平上皮癌(ESCC)に対して根治的食道切除術を行った222例(男性179例、女性43例、平均年齢63.7歳)を検討対象とした。(a)体温>38℃または<36℃、(b)心拍数>90回/分、(c)呼吸回数>20回/分、(d)白血球数>12000または<4000/mm3、の4項目中2項目以上を満たす場合を、全身性炎症反応症候群(SIRS)と定義した。SIRS期間は術後7日までのうちSIRSの診断基準を満たした日数と定義した。5年全生存率をエンドポイントとして描いた受信者操作特性曲線解析の結果、SIRS期間のカットオフ値は5.0日であった。222症例のうち、165例(74.4%)および57例(25.6%)がそれぞれ短期(<5.0)および長期(≧5.0)SIRSに分類された。ロジスティック回帰分析の結果、長期SIRSは、術後肺炎、術中大量出血、術後高CRP値および術後低アルブミン血症と有意に関連していた。多変量Cox比例ハザード分析の結果、長期SIRSは全生存率(OS)および癌特異的生存率(CSS)に関する有意な増悪因子であった。術後肺炎および術後高CRP値はいずれもOS、CSSの増悪因子ではなかった。

  • Molecular-targeted therapy toward precision medicine for gastrointestinal caner: Current progress and challenges. Reviewed

    Matsuoka T, Yashiro M

    World journal of gastrointestinal oncology   13 ( 5 )   366 - 390   2021.05( ISSN:1948-5204

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    DOI: 10.4251/wjgo.v13.i5.366

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  • Clinicopathologic significance of TROP2 and phospho-TROP2 in gastric cancer Reviewed

    Kushiyama Shuhei, Yashiro Masakazu, Yamamoto Yurie, Sera Tomohiro, Sugimoto Atsushi, Nishimura Sadaaki, Togano Shingo, Kuroda Kenji, Yoshii Mami, Tamura Tatsuro, Toyokawa Takahiro, Tanaka Hiroaki, Muguruma Kazuya, Nakada Hiroshi, Ohira Masaichi

    MOLECULAR AND CLINICAL ONCOLOGY   14 ( 5 )   105   2021.05( ISSN:2049-9450

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    DOI: 10.3892/mco.2021.2267

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  • Clinicopathologic significance of TROP2 and phospho-TROP2 in gastric cancer. Reviewed

    Kushiyama S, Yashiro M, Yamamoto Y, Sera T, Sugimoto A, Nishimura S, Togano S, Kuroda K, Yoshii M, Tamura T, Toyokawa T, Tanaka H, Muguruma K, Nakada H, Ohira M

    Molecular and clinical oncology   14 ( 5 )   105   2021.05( ISSN:2049-9450

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    DOI: 10.3892/mco.2021.2267

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  • Expression of asporin reprograms cancer cells to acquire resistance to oxidative stress Reviewed

    Sasaki Yuto, Takagane Kurara, Konno Takumi, Itoh Go, Kuriyama Sei, Yanagihara Kazuyoshi, Yashiro Masakazu, Yamada Satoru, Murakami Shinya, Tanaka Masamitsu

    CANCER SCIENCE   112 ( 3 )   1251 - 1261   2021.03( ISSN:1347-9032

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    DOI: 10.1111/cas.14794

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  • Expression of asporin reprograms cancer cells to acquire resistance to oxidative stress. Reviewed

    Sasaki Y, Takagane K, Konno T, Itoh G, Kuriyama S, Yanagihara K, Yashiro M, Yamada S, Murakami S, Tanaka M

    Cancer science   112 ( 3 )   1251 - 1261   2021.03( ISSN:1347-9032

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    DOI: 10.1111/cas.14794

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  • アスポリンの発現は癌細胞をリプログラミングし、酸化ストレスに対する耐性を獲得させる(Expression of asporin reprograms cancer cells to acquire resistance to oxidative stress) Reviewed

    Sasaki Yuto, Takagane Kurara, Konno Takumi, Itoh Go, Kuriyama Sei, Yanagihara Kazuyoshi, Yashiro Masakazu, Yamada Satoru, Murakami Shinya, Tanaka Masamitsu

    Cancer Science   112 ( 3 )   1251 - 1261   2021.03( ISSN:1347-9032

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    変形性関節症の感受性遺伝子として知られるアスポリンの胃癌における関与を検討した。アスポリンを胃癌細胞株(HSC-43細胞と44As3細胞)で過剰発現させると、CD44の発現誘導とRac1とMMP9の活性化を伴って、遊走能と浸潤能が亢進した。アスポリンの発現は、ミトコンドリアの活性酸素種を減少させることにより、胃癌細胞株の酸化ストレスに対する耐性を高めた。アスポリンは、転写因子HIF1αの発現を誘導し、乳酸脱水素酵素AおよびPDH-E1αの発現を亢進させた。それにより、アスポリンがHSC-43細胞を嫌気的な解糖に再プログラムし、ミトコンドリアでの活性酸素の生成を抑制していると考えられた。対照的に、44As3細胞は酸化ストレスに反応して高レベルのHIF1αを発現し、アスポリンの発現にかかわらずアポトーシスを免れた。アスポリンノックアウトマウスの胃壁に移植された異種移植片を調べたところ、微小血管密度が増加したHSC-43腫瘍の増殖はアスポリンによって著しく促進され、アスポリンはHSC-43腫瘍と44As3腫瘍の両方の浸潤の深さを増加させた。以上より、アスポリンは、グルコース代謝の再プログラムを介したHIF1αによる酸化ストレスへの耐性およびCD44-Rac1とMMP9の活性化による細胞の遊走と浸潤の促進という2つの異なる作用を持つことが示唆された。

  • Clinical benefit for clinical sequencing using cancer panel testing Reviewed

    Nishimura Sadaaki, Sugimoto Atsushi, Kushiyama Shuhei, Togano Shingo, Kuroda Kenji, Yamamoto Yurie, Yamauchi Makoto, Sumi Toshiyuki, Kaneda Hiroyasu, Kawaguchi Tomoya, Kato Minoru, Tagami Mizuki, Oebisu Naoto, Hoshi Manabu, Kimura Kenjiro, Kubo Shoji, Muguruma Kazuya, Takashima Tsutomu, Ohira Masaichi, Yashiro Masakazu

    PLOS ONE   16 ( 2 )   e0247090   2021.02( ISSN:1932-6203

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    DOI: 10.1371/journal.pone.0247090

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  • Clinical difference between fibroblast growth factor receptor 2 subclass, type IIIb and type IIIc, in gastric cancer Reviewed

    Yashiro Masakazu, Kuroda Kenji, Masuda Go, Okuno Tomohisa, Miki Yuichiro, Yamamoto Yurie, Sera Tomohiro, Sugimoto Atsushi, Kushiyama Shuhei, Nishimura Sadaaki, Togano Shingo, Ohira Masaichi

    SCIENTIFIC REPORTS   11 ( 1 )   4698   2021.02( ISSN:2045-2322

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    DOI: 10.1038/s41598-021-84107-x

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  • Clinical difference between fibroblast growth factor receptor 2 subclass, type IIIb and type IIIc, in gastric cancer. Reviewed

    Yashiro M, Kuroda K, Masuda G, Okuno T, Miki Y, Yamamoto Y, Sera T, Sugimoto A, Kushiyama S, Nishimura S, Togano S, Ohira M

    Scientific reports   11 ( 1 )   4698   2021.02

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    DOI: 10.1038/s41598-021-84107-x

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  • The duration of systemic inflammatory response syndrome is a reliable indicator of long-term survival after curative esophagectomy for esophageal squamous cell carcinoma Reviewed

    Kubo Naoshi, Sakurai Katsunobu, Tamura Tatsuro, Toyokawa Takahiro, Tanaka Hiroaki, Muguruma Kazuya, Yashiro Masakazu, Maeda Kiyoshi, Ohira Masaichi

    ESOPHAGUS   2021.02( ISSN:1612-9059

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    DOI: 10.1007/s10388-021-00821-5

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  • Analysis of clinicopathologic factors associated with false negative of lymph node metastasis by FDG-PET in lung cancer Reviewed

    Ito Ryuichi, Yashiro Masakazu, Inoue Hidetoshi

    CANCER SCIENCE   112   498 - 498   2021.02( ISSN:1347-9032

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  • The clinicopathological significance of CXCR2 ligand family in gastric carcinoma Reviewed

    Yamamoto Yurie, Yashiro Masakazu, Sera Tomohiro, Sugimoto Atsushi, Kushiyama Shuhei, Nishimura Sadaaki, Togano Shingo, Kuroda Kenji, Okuno Tomohisa, Yoshii Mami, Tamura Tatsuro, Toyokawa Takahiro, Tanaka Hiroaki, Muguruma Kazuya, Ohira Masaichi

    CANCER SCIENCE   112   422 - 422   2021.02( ISSN:1347-9032

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  • Spondin2 secreted from cancer-associated fibroblasts (CAF) facilitates gastric cancer motility Reviewed

    Saito Hideyuki, Masuda Takaaki, Kuramitsu Shotaro, Yashiro Masakazu, Koike Kensuke, Kobayashi Yuta, Takahashi Junichi, Takao Seiichiro, Motomura Yushi, Otsu Hajime, Takeishi Kazuki, Yonemura Yusuke, Saeki Hiroshi, Mimori Koshi

    CANCER SCIENCE   112   358 - 358   2021.02( ISSN:1347-9032

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  • Significance of Circulating Tumor Cells with Fibroblast growth factor receptor 2 Expression in Gastric Cancer Reviewed

    Kuroda Kenji, Yashiro Masakazu, Miki Yuichiro, Sera Tomohiro, Yamamoto Yurie, Sugimoto Atsushi, Nishimura Sadaaki, Kushiyama Shuhei, Togano Shingo, Okuno Tomohisa, Ohira Masaichi

    CANCER SCIENCE   112   475 - 475   2021.02( ISSN:1347-9032

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  • Scirrhous gastric cancer extracellular vesicles cells might stimulate the proliferation of cancer-associated fibroblasts Reviewed

    Sugimoto Atsushi, Yashiro Masakazu, Okuno Tomohisa, Miki Yuichiro, Yamamoto Yurie, Sera Tomohiro, Kushiyama Shuhei, Nishimura Sadaaki, Kuroda Kenji, Togano Shingo, Ohira Masaichi

    CANCER SCIENCE   112   712 - 712   2021.02( ISSN:1347-9032

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  • Is Cancer Panel Testing useful for cancer treatment? Reviewed

    Nishimura Sadaaki, Sugimoto Atsushi, Kushiyama Shuhei, Togano Shingo, Kuroda Kenji, Yamauchi Makoto, Sumi Toshiyuki, Sawa Kenji, Kawaguchi Tomoya, Kimura Kenjiro, Nagahara Hisashi, Muguruma Kazuya, Takashima Tsutomu, Ohira Masaichi, Yashiro Masakazu

    CANCER SCIENCE   112   325 - 325   2021.02( ISSN:1347-9032

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  • Dynamics of giant cancer cells cooperating with cancer associated fibroblasts Reviewed

    Itoh Go, Yashiro Masakazu, Tanaka Masamitsu

    CANCER SCIENCE   112   307 - 307   2021.02( ISSN:1347-9032

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  • Distance from tumor to serosa might be a useful predictive factor for dissemination after operation of T3-gastric cancer Reviewed

    Togano Shingo, Yashiro Masakazu, Miki Yuichiro, Yamamoto Yurie, Sera Tomohiro, Sugimoto Atsushi, Kushiyama Shuhei, Nishimura Sadaaki, Kuroda Kenji, Okuno Tomohisa, Tanaka Hiroaki, Muguruma Kazuya, Tanaka Sayaka, Ohira Masaichi

    CANCER SCIENCE   112   782 - 782   2021.02( ISSN:1347-9032

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  • Clinicopathological significance of TROP-2 and pTROP-2 in gastric cancer Reviewed

    Kushiyama Shuhei, Yashiro Masakazu, Nishimura Sadaaki, Togano Shingo, Kuroda Kenji, Sugimoto Atsushi, Sera Tomohiro, Yamamoto Yurie, Okuno Tomohisa, Miki Yuichiro, Nakada Hiroshi, Ohira Masaichi

    CANCER SCIENCE   112   780 - 780   2021.02( ISSN:1347-9032

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  • Clinical significance of BRACAnalysis and PARP inhibitors at Osaka City University Hospital Reviewed

    Sera Tomohiro, Takashima Tsutomu, Yamamoto Yurie, Sugimoto Atsushi, Kushiyama Shuhei, Nishimura Sadaaki, Kashiwagi Shinichiro, Ohira Masaichi, Yashiro Masakazu

    CANCER SCIENCE   112   825 - 825   2021.02( ISSN:1347-9032

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  • CEA positive circulating tumor cells and its clinical significance Reviewed

    Miki Yuichiro, Yashiro Masakazu, Kuroda Kenji, Yoshii Mami, Tamura Tatsuro, Toyokawa Takahiro, Tanaka Hiroaki, Lee Shigeru, Muguruma Kazuya, Ohira Masaichi

    CANCER SCIENCE   112   425 - 425   2021.02( ISSN:1347-9032

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  • Cancer-associated fibroblasts educate normal fibroblasts to facilitate gastric cancer dissemination Reviewed

    Tanaka Masamitsu, Itoh Go, Takagane Kurara, Kuriyama Sei, Yashiro Masakazu

    CANCER SCIENCE   112   356 - 356   2021.02( ISSN:1347-9032

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  • Stromal SOX2 Upregulation Promotes Tumorigenesis through the Generation of a SFRP1/2-Expressing Cancer-Associated Fibroblast Population Reviewed

    Kasashima Hiroaki, Duran Angeles, Martinez-Ordonez Anxo, Nakanishi Yuki, Kinoshita Hiroto, Linares Juan F., Reina-Campos Miguel, Kudo Yotaro, L'Hermitte Antoine, Yashiro Masakazu, Ohira Masaichi, Bao Fei, Tauriello Daniele V. F., Batlle Eduard, Diaz-Meco Maria T., Moscat Jorge

    DEVELOPMENTAL CELL   56 ( 1 )   95 - +   2021.01( ISSN:1534-5807

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    DOI: 10.1016/j.devcel.2020.10.014

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  • Stromal SOX2 Upregulation Promotes Tumorigenesis through the Generation of a SFRP1/2-Expressing Cancer-Associated Fibroblast Population. Reviewed

    Kasashima H, Duran A, Martinez-Ordoñez A, Nakanishi Y, Kinoshita H, Linares JF, Reina-Campos M, Kudo Y, L'Hermitte A, Yashiro M, Ohira M, Bao F, Tauriello DVF, Batlle E, Diaz-Meco MT, Moscat J

    Developmental cell   56 ( 1 )   95 - 110.e10   2021.01( ISSN:1534-5807

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    DOI: 10.1016/j.devcel.2020.10.014

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  • Circulating CEA-positive and EpCAM-negative tumor cells might be a predictive biomarker for recurrence in patients with gastric cancer Reviewed

    Miki Yuichiro, Yashiro Masakazu, Kuroda Kenji, Okuno Tomohisa, Togano Shingo, Masuda Go, Kasashima Hiroaki, Ohira Masaichi

    CANCER MEDICINE   10 ( 2 )   521 - 528   2021.01( ISSN:2045-7634

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    DOI: 10.1002/cam4.3616

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  • SDF1 alpha/CXCR4 axis may be associated with the malignant progression of gastric cancer in the hypoxic tumor microenvironment Reviewed

    Yashiro Masakazu, Kinoshita Haruhito, Tsujio Gen, Fukuoka Tatsunari, Yamamoto Yurie, Sera Tomohiro, Sugimoto Atsushi, Nishimura Sadaaki, Kushiyama Shuhei, Togano Shingo, Kuroda Kenji, Toyokawa Takahiro, Ohira Masaichi

    ONCOLOGY LETTERS   21 ( 1 )   38   2021.01( ISSN:1792-1074

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    DOI: 10.3892/ol.2020.12299

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  • Combination of p53 and Ki67 as a Promising Predictor of Postoperative Recurrence of Meningioma Reviewed

    Nagahama Atsufumi, Yashiro Masakazu, Kawashima Toshiyuki, Nakajo Kosuke, Morisako Hiroki, Uda Takehiro, Naito Kentaro, Ichinose Tsutomu, Ohata Kenji, Goto Takeo

    ANTICANCER RESEARCH   41 ( 1 )   203 - 210   2021.01( ISSN:0250-7005

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    DOI: 10.21873/anticanres.14766

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  • Circulating CEA-positive and EpCAM-negative tumor cells might be a predictive biomarker for recurrence in patients with gastric cancer. Reviewed

    Miki Y, Yashiro M, Kuroda K, Okuno T, Togano S, Masuda G, Kasashima H, Ohira M

    Cancer medicine   10 ( 2 )   521 - 528   2021.01

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    DOI: 10.1002/cam4.3616

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  • SDF1α/CXCR4 axis may be associated with the malignant progression of gastric cancer in the hypoxic tumor microenvironment. Reviewed

    Yashiro M, Kinoshita H, Tsujio G, Fukuoka T, Yamamoto Y, Sera T, Sugimoto A, Nishimura S, Kushiyama S, Togano S, Kuroda K, Toyokawa T, Ohira M

    Oncology letters   21 ( 1 )   38   2021.01( ISSN:1792-1074

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    DOI: 10.3892/ol.2020.12299

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  • Combination of p53 and Ki67 as a Promising Predictor of Postoperative Recurrence of Meningioma. Reviewed

    Nagahama A, Yashiro M, Kawashima T, Nakajo K, Morisako H, Uda T, Naito K, Ichinose T, Ohata K, Goto T

    Anticancer research   41 ( 1 )   203 - 210   2021.01( ISSN:0250-7005

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    DOI: 10.21873/anticanres.14766

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  • Does clinical sequencing bridge to clinical benefit in cancer treatment? Reviewed

    Nishimura Sadaaki, Kato Minoru, Kimura Kenjiro, Nagahara Hisashi, Muguruma Kazuya, Lee Shigeru, Takashima Tsutomu, Kubo Shoji, Ohira Masaichi, Yashiro Masakazu, Sugimoto Atsushi, Kushiyama Shuhei, Togano Shingo, Kuroda Kenji, Yamauchi Makoto, Sumi Toshiyuki, Kaneda Hiroyasu, Kawaguchi Tomoya

    Japanese Society for Molecular Tumor Marker Research, Japan Journal of Molecular Tumor Marker Research   36 ( 0 )   5 - 6   2021

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    DOI: 10.11241/jsmtmr.36.5

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  • Asporin Expression on Stromal Cells and/or Cancer Cells Might Be A Useful Prognostic Marker in Patients with Diffuse-Type Gastric Cancer. Reviewed

    Yashiro M, Hasegawa T, Yamamoto Y, Tsujio G, Nishimura S, Sera T, Sugimoto A, Kushiyama S, Kasashima H, Fukuoka T, Sakurai K, Toyokawa T, Kubo N, Ohira M

    European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes   62 ( 1 )   53 - 60   2021( ISSN:0014-312X

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    DOI: 10.1159/000515458

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  • Does clinical sequencing bridge to clinical benefit in cancer treatment? Reviewed

    Nishimura Sadaaki, Sugimoto Atsushi, Kushiyama Shuhei, Togano Shingo, Kuroda Kenji, Yamauchi Makoto, Sumi Toshiyuki, Kaneda Hiroyasu, Kawaguchi Tomoya, Kato Minoru, Kimura Kenjiro, Nagahara Hisashi, Muguruma Kazuya, Lee Shigeru, Takashima Tsutomu, Kubo Shoji, Ohira Masaichi, Yashiro Masakazu

    Japan Journal of Molecular Tumor Marker Research   36 ( 0 )   5 - 6   2021( eISSN:24338575

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    DOI: 10.11241/jsmtmr.36.5

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  • The clinicopathologic significance of Tks5 expression of peritoneal mesothelial cells in gastric cancer patients. Reviewed

    Sugimoto A, Okuno T, Tsujio G, Sera T, Yamamoto Y, Maruo K, Kushiyama S, Nishimura S, Kuroda K, Togano S, Miki Y, Yoshii M, Tamura T, Toyokawa T, Tanaka H, Muguruma K, Ohira M, Yashiro M

    PloS one   16 ( 7 )   e0253702   2021

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    DOI: 10.1371/journal.pone.0253702

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  • Clinical benefit for clinical sequencing using cancer panel testing. Reviewed

    Nishimura S, Sugimoto A, Kushiyama S, Togano S, Kuroda K, Yamamoto Y, Yamauchi M, Sumi T, Kaneda H, Kawaguchi T, Kato M, Tagami M, Oebisu N, Hoshi M, Kimura K, Kubo S, Muguruma K, Takashima T, Ohira M, Yashiro M

    PloS one   16 ( 2 )   e0247090   2021

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  • Circulating tumor cells with FGFR2 expression might be useful to identify patients with existing FGFR2-overexpressing tumor Reviewed

    Kuroda Kenji, Yashiro Masakazu, Miki Yuichiro, Sera Tomohiro, Yamamoto Yurie, Sugimoto Atsushi, Nishimura Sadaaki, Kushiyama Shuhei, Togano Shingo, Okuno Tomohisa, Ohira Masaichi

    CANCER SCIENCE   111 ( 12 )   4500 - 4509   2020.12( ISSN:1347-9032

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    DOI: 10.1111/cas.14654

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  • Circulating tumor cells with FGFR2 expression might be useful to identify patients with existing FGFR2-overexpressing tumor(和訳中) Reviewed

    Kuroda Kenji, Yashiro Masakazu, Miki Yuichiro, Sera Tomohiro, Yamamoto Yurie, Sugimoto Atsushi, Nishimura Sadaaki, Kushiyama Shuhei, Togano Shingo, Okuno Tomohisa, Ohira Masaichi

    John Wiley & Sons Australia, Ltd Cancer Science   111 ( 12 )   4500 - 4509   2020.12( ISSN:1347-9032

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  • FGFR2発現を伴う循環腫瘍細胞は既存FGFR2過剰発現腫瘍患者の同定に有用である(Circulating tumor cells with FGFR2 expression might be useful to identify patients with existing FGFR2-overexpressing tumor) Reviewed

    Kuroda Kenji, Yashiro Masakazu, Miki Yuichiro, Sera Tomohiro, Yamamoto Yurie, Sugimoto Atsushi, Nishimura Sadaaki, Kushiyama Shuhei, Togano Shingo, Okuno Tomohisa, Ohira Masaichi

    Cancer Science   111 ( 12 )   4500 - 4509   2020.12( ISSN:1347-9032

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    血液中に循環するFGFR2の過剰発現を伴う循環腫瘍細胞(CTC)の同定が、FGFR2過剰発現の胃癌患者の検出に有用性かどうかについて検討した。胃切除術を受けた胃癌患者100例を対象として、胃切除術の直前に各患者から総量8mLの末梢血を採取し、フィコール密度勾配遠心法により単核細胞を濃縮した。各細胞検体でFGFR2を発現しているCTC数をフローサイトメーターで測定した。切除した原発腫瘍のFGFR2発現レベルは免疫組織化学検査で評価した。その結果、胃癌患者の末梢血中のFGFR2陽性CTC数は、原発性胃癌のFGFR2発現レベルと有意に相関していた。FGFR2陽性CTCを持つ患者(≧5細胞/10mL血液)の無再発生存率は、FGFR2陽性CTCを持たない患者(<5細胞/10mL血液)よりも有意に低かった。FGFR2陽性CTCを判定することにより、FGFR2を過剰発現する胃癌を特定できる可能性が示唆された。

  • Circulating tumor cells with FGFR2 expression might be useful to identify patients with existing FGFR2-overexpressing tumor. Reviewed

    Kuroda K, Yashiro M, Miki Y, Sera T, Yamamoto Y, Sugimoto A, Nishimura S, Kushiyama S, Togano S, Okuno T, Ohira M

    Cancer science   111 ( 12 )   4500 - 4509   2020.12( ISSN:1347-9032

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  • Futibatinib Is a Novel Irreversible FGFR 1-4 Inhibitor That Shows Selective Antitumor Activity against FGFR-Deregulated Tumors. Reviewed

    Sootome H, Fujita H, Ito K, Ochiiwa H, Fujioka Y, Ito K, Miura A, Sagara T, Ito S, Ohsawa H, Otsuki S, Funabashi K, Yashiro M, Matsuo K, Yonekura K, Hirai H

    Cancer research   80 ( 22 )   4986 - 4997   2020.11( ISSN:0008-5472

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    DOI: 10.1158/0008-5472.CAN-19-2568

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  • Serine threonine kinase 11/liver kinase B1 mutation in sporadic scirrhous-type gastric cancer cells. Reviewed

    Nishimura S, Yashiro M, Sera T, Yamamoto Y, Kushitani Y, Sugimoto A, Kushiyama S, Togano S, Kuroda K, Okuno T, Murakami Y, Ohira M

    Carcinogenesis   41 ( 11 )   1616 - 1623   2020.11( ISSN:0143-3334

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    DOI: 10.1093/carcin/bgaa031

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  • Clinical update with plasma and tumour-based genomic analyses in expansion part of phase I study of selective FGFR inhibitor E7090 Reviewed

    Morizane C., Ueno M., Ioka T., Tajika M., Ikeda M., Yamaguchi K., Hara H., Yabusaki H., Miyamoto A., Iwasa S., Muto M., Takashima T., Minashi K., Komatsu Y., Nishina T., Nakajima T., Sahara T., Funasaka S., Yashiro M., Furuse J.

    ANNALS OF ONCOLOGY   31   S1292 - S1293   2020.11( ISSN:0923-7534

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    DOI: 10.1016/j.annonc.2020.10.149

  • Serine threonine kinase 11/liver kinase B1 mutation in sporadic scirrhous-type gastric cancer cells Reviewed

    Nishimura Sadaaki, Yashiro Masakazu, Sera Tomohiro, Yamamoto Yurie, Kushitani Yukako, Sugimoto Atsushi, Kushiyama Shuhei, Togano Shingo, Kuroda Kenji, Okuno Tomohisa, Murakami Yoshiki, Ohira Masaichi

    CARCINOGENESIS   41 ( 11 )   1616 - 1623   2020.11( ISSN:0143-3334

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    DOI: 10.1093/carcin/bgaa031

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  • Futibatinib Is a Novel Irreversible FGFR 1-4 Inhibitor That Shows Selective Antitumor Activity against FGFR-Deregulated Tumors Reviewed

    Sootome Hiroshi, Fujita Hidenori, Ito Kenjiro, Ochiiwa Hiroaki, Fujioka Yayoi, Ito Kimihiro, Miura Akihiro, Sagara Takeshi, Ito Satoru, Ohsawa Hirokazu, Otsuki Sachie, Funabashi Kaoru, Yashiro Masakazu, Matsuo Kenichi, Yonekura Kazuhiko, Hirai Hiroshi

    CANCER RESEARCH   80 ( 22 )   4986 - 4997   2020.11( ISSN:0008-5472

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    DOI: 10.1158/0008-5472.CAN-19-2568

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  • Crosstalk Between Cancer Associated Fibroblasts and Cancer Cells in Scirrhous Type Gastric Cancer Reviewed

    Miki Yuichiro, Yashiro Masakazu, Moyano-Galceran Lidia, Sugimoto Atsushi, Ohira Masaichi, Lehti Kaisa

    FRONTIERS IN ONCOLOGY   10   568557   2020.10( ISSN:2234-943X

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    DOI: 10.3389/fonc.2020.568557

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  • CXCR2リガンドファミリーの胃癌における臨床病理学的因子への関与 Reviewed

    山本 百合恵, 八代 正和, 瀬良 知央, 杉本 敦史, 櫛山 周平, 西村 貞徳, 栂野 真吾, 黒田 顕慈, 奥野 倫久, 吉井 真美, 田村 達郎, 豊川 貴弘, 田中 浩明, 六車 一哉, 大平 雅一

    日本癌学会総会記事   79回   OJ13 - 2   2020.10( ISSN:0546-0476

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  • 腫瘍先進部-漿膜間距離の測定は治癒切除したT3胃癌の腹膜播種再発の予測に有用である Reviewed

    栂野 真吾, 八代 正和, 三木 友一朗, 山本 百合恵, 瀬良 知央, 杉本 敦史, 櫛山 周平, 西村 貞徳, 黒田 顕慈, 奥野 倫久, 田中 浩明, 六車 一哉, 田中 さやか, 大平 雅一

    日本癌学会総会記事   79回   PJ14 - 3   2020.10( ISSN:0546-0476

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  • 胃癌のFGFR2発現の診断にCirculating Tumor Cells測定を用いた検討 Reviewed

    黒田 顕慈, 八代 正和, 三木 友一朗, 瀬良 知央, 山本 百合恵, 杉本 敦史, 西村 貞徳, 櫛山 周平, 栂野 真吾, 奥野 倫久, 大平 雅一

    日本癌学会総会記事   79回   OJ14 - 3   2020.10( ISSN:0546-0476

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  • 癌パネル検査は癌治療においてはたして有用か? Reviewed

    西村 貞徳, 杉本 敦史, 櫛山 周平, 栂野 真吾, 黒田 顕慈, 山内 真, 角 俊幸, 澤 兼二, 川口 知哉, 木村 健二郎, 永原 央, 六車 一哉, 高島 勉, 大平 雅一, 八代 正和

    日本癌学会総会記事   79回   OJ7 - 9   2020.10( ISSN:0546-0476

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  • 癌パネル検査は癌治療においてはたして有用か? Reviewed

    西村 貞徳, 杉本 敦史, 櫛山 周平, 栂野 真吾, 黒田 顕慈, 山内 真, 角 俊幸, 澤 兼二, 川口 知哉, 木村 健二郎, 永原 央, 六車 一哉, 高島 勉, 大平 雅一, 八代 正和

    日本癌学会総会記事   79回   OJ7 - 9   2020.10( ISSN:0546-0476

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  • 大阪市立大学病院におけるBRACAnalysisとPARP阻害薬の臨床的意義 Reviewed

    瀬良 知央, 高島 勉, 山本 百合恵, 杉本 敦史, 櫛山 周平, 西村 貞徳, 柏木 伸一郎, 大平 雅一, 八代 正和

    日本癌学会総会記事   79回   PJ14 - 10   2020.10( ISSN:0546-0476

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  • スキルス胃癌細胞由来細胞外小胞は癌関連線維芽細胞の増殖を促進する Reviewed

    杉本 敦史, 八代 正和, 奥野 倫久, 三木 友一朗, 山本 百合恵, 瀬良 知央, 櫛山 周平, 西村 貞徳, 黒田 顕慈, 栂野 真吾, 大平 雅一

    日本癌学会総会記事   79回   PJ11 - 2   2020.10( ISSN:0546-0476

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  • スキルス胃癌細胞の変異遺伝子STK11/LKB1の同定 Reviewed

    西村 貞徳, 八代 正和, 瀬良 知央, 山本 百合恵, 杉本 敦史, 櫛山 周平, 栂野 真吾, 黒田 顕慈, 奥野 倫久, 村上 善基, 大平 雅一

    日本癌治療学会学術集会抄録集   58回   O86 - 4   2020.10

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  • がん遺伝子パネル検査を用いたクリニカルシーケンスの課題と現状 Reviewed

    西村 貞徳, 杉本 敦史, 櫛山 周平, 栂野 真吾, 黒田 顕慈, 山内 真, 角 俊幸, 金田 裕靖, 川口 知哉, 加藤 実, 木村 健二郎, 永原 央, 六車 一哉, 李 栄柱, 高島 勉, 久保 正二, 大平 雅一, 八代 正和

    日本分子腫瘍マーカー研究会プログラム・講演抄録   40回   42 - 43   2020.09

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  • Extracellular Vesicles from Cancer-Associated Fibroblasts Containing Annexin A6 Induces FAK-YAP Activation by Stabilizing beta 1 Integrin, Enhancing Drug Resistance Reviewed

    Uchihara Tomoyuki, Miyake Keisuke, Yonemura Atsuko, Komohara Yoshihiro, Itoyama Rumi, Koiwa Mayu, Yasuda Tadahito, Arima Kota, Harada Kazuto, Eto Kojiro, Hayashi Hiromitsu, Iwatsuki Masaaki, Iwagami Shiro, Baba Yoshifumi, Yoshida Naoya, Yashiro Masakazu, Masuda Mari, Ajani Jaffer A., Tan Patrick, Baba Hideo, Ishimoto Takatsugu

    CANCER RESEARCH   80 ( 16 )   3222 - 3235   2020.08( ISSN:0008-5472

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    DOI: 10.1158/0008-5472.CAN-19-3803

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  • Extracellular Vesicles from Cancer-Associated Fibroblasts Containing Annexin A6 Induces FAK-YAP Activation by Stabilizing β1 Integrin, Enhancing Drug Resistance. Reviewed

    Uchihara T, Miyake K, Yonemura A, Komohara Y, Itoyama R, Koiwa M, Yasuda T, Arima K, Harada K, Eto K, Hayashi H, Iwatsuki M, Iwagami S, Baba Y, Yoshida N, Yashiro M, Masuda M, Ajani JA, Tan P, Baba H, Ishimoto T

    Cancer research   80 ( 16 )   3222 - 3235   2020.08( ISSN:0008-5472

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    DOI: 10.1158/0008-5472.CAN-19-3803

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  • Association between FGFR4 Gly388Arg polymorphism rs351855 or the IDH1 rs11554137 and Japanese gastric cancer Reviewed

    Sera Tomohiro, Yashiro Masakazu, Yamamoto Yurie, Kushitani Yukako, Sugimoto Atsushi, Kushiyama Syuhei, Kuroda Kenji, Togano Shingo, Okuno Tomohisa, Yoshii Mami, Tamura Tatsuro, Toyokawa Takahiro, Tanaka Hiroaki, Muguruma Kazuya, Ohira Masaichi

    CANCER RESEARCH   80 ( 16 )   2020.08( ISSN:0008-5472

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    DOI: 10.1158/1538-7445.AM2020-5856

  • Serine threonine kinase 11/liver kinase B1 mutation in sporadic scirrhous-type gastric cancer cells Reviewed

    Nishimura Sadaaki, Yashiro Masakazu, Sera Tomohiro, Yamamoto Yurie, Sugimoto Atsushi, Kushiyama Shuhei, Togano Shingo, Kuroda Kenji, Okuno Tomohisa, Ohira Masaichi

    CANCER RESEARCH   80 ( 16 )   2020.08( ISSN:0008-5472

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    DOI: 10.1158/1538-7445.AM2020-1217A

  • Lysyl oxidase is associated with the epithelial-mesenchymal transition of gastric cancer cells in hypoxia Reviewed

    Yashiro Masakazu, Kasashima Hiroaki, Yamamoto Yurie, Kuroda Kenji, Sera Tomohiro, Sugimoto Atsushi, Kushiyama Shuhei, Togano Shingo, Okuno Tomohisa, Miki Yuichiro, Ohira Masaichi

    CANCER RESEARCH   80 ( 16 )   2020.08( ISSN:0008-5472

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    DOI: 10.1158/1538-7445.AM2020-3566

  • Clinicopathological features of TROP-2 and pTROP-2 in gastric cancer Reviewed

    Kushiyama Syuhei, Yashiro Masakazu, Nishimura Sadaaki, Togano Shingo, Kuroda Kanji, Sugimoto Atsushi, Sera Tomohiro, Yamamoto Yurie, Okuno Tomohisa, Miki Yuichiro, Nakada Hiroshi, Ohira Masaichi

    CANCER RESEARCH   80 ( 16 )   2020.08( ISSN:0008-5472

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    DOI: 10.1158/1538-7445.AM2020-6465

  • スキルス胃癌におけるSTK11/LKB1遺伝子の意義 Reviewed

    西村 貞徳, 八代 正和, 瀬良 知央, 山本 百合恵, 櫛谷 友佳子, 杉本 敦史, 櫛山 周平, 栂野 真吾, 黒田 顕慈, 奥野 倫久, 三木 友一朗, 大平 雅一

    日本外科学会定期学術集会抄録集   120回   SF - 2   2020.08

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  • 胃癌患者におけるFGFR2をマーカーにしたCirculating Tumor Cells測定の意義 Reviewed

    黒田 顕慈, 八代 正和, 三木 友一朗, 杉本 敦史, 瀬良 知央, 山本 百合恵, 櫛山 周平, 西村 貞徳, 栂野 真吾, 奥野 倫久, 吉井 真美, 田村 達郎, 豊川 貴弘, 田中 浩明, 六車 一哉, 大平 雅一

    日本外科学会定期学術集会抄録集   120回   SF - 5   2020.08

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  • 胃癌幹細胞のオートファジーの意義 Reviewed

    栂野 真吾, 八代 正和, 三木 友一朗, 山本 百合恵, 瀬良 知央, 櫛谷 友佳子, 杉本 敦史, 櫛山 周平, 西村 貞徳, 黒田 顕慈, 奥野 倫久, 吉井 真美, 田村 達郎, 豊川 貴弘, 田中 浩明, 六車 一哉, 大平 雅一

    日本外科学会定期学術集会抄録集   120回   DP - 7   2020.08

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  • 胃癌におけるCXCケモカインファミリー発現の臨床学的意義 Reviewed

    山本 百合恵, 八代 正和, 瀬良 知央, 櫛谷 友佳子, 杉本 敦史, 櫛山 周平, 西村 貞徳, 黒田 顕慈, 栂野 真吾, 奥野 倫久, 田村 達郎, 豊川 貴弘, 田中 浩明, 六車 一哉, 大平 雅一

    日本外科学会定期学術集会抄録集   120回   RS - 3   2020.08

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  • スキルス胃癌細胞由来のエクソソームは癌関連線維芽細胞の増殖を促進する Reviewed

    杉本 敦史, 八代 正和, 山本 百合恵, 瀬良 知央, 櫛谷 友佳子, 櫛山 周平, 西村 貞徳, 黒田 顕慈, 田中 涼太, 栂野 真吾, 奥野 倫久, 大平 雅一

    日本外科学会定期学術集会抄録集   120回   DP - 3   2020.08

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  • スキルス胃癌細胞に対する癌関連線維芽細胞由来の新規増殖促進因子の検討 Reviewed

    櫛山 周平, 八代 正和, 西村 貞徳, 栂野 真吾, 黒田 顕慈, 杉本 敦史, 瀬良 知央, 山本 百合恵, 奥野 倫久, 三木 友一朗, 大平 雅一

    日本外科学会定期学術集会抄録集   120回   DP - 6   2020.08

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  • Cancer cells with high-metastatic potential promote a glycolytic shift in activated fibroblasts Reviewed

    Kogure Akiko, Naito Yutaka, Yamamoto Yusuke, Yashiro Masakazu, Kiyono Tohru, Yanagihara Kazuyoshi, Hirakawa Kosei, Ochiya Takahiro

    PLOS ONE   15 ( 6 )   e0234613   2020.06( ISSN:1932-6203

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    DOI: 10.1371/journal.pone.0234613

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  • Clinical significance of prognostic inflammation-based and/or nutritional markers in patients with stage III gastric cancer Reviewed

    Toyokawa Takahiro, Muguruma Kazuya, Yoshii Mami, Tamura Tatsuro, Sakurai Katsunobu, Kubo Naoshi, Tanaka Hiroaki, Lee Shigeru, Yashiro Masakazu, Ohira Masaichi

    BMC CANCER   20 ( 1 )   517   2020.06

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    DOI: 10.1186/s12885-020-07010-0

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  • Clinical significance of prognostic inflammation-based and/or nutritional markers in patients with stage III gastric cancer. Reviewed

    Toyokawa T, Muguruma K, Yoshii M, Tamura T, Sakurai K, Kubo N, Tanaka H, Lee S, Yashiro M, Ohira M

    BMC cancer   20 ( 1 )   517   2020.06

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    DOI: 10.1186/s12885-020-07010-0

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  • Establishment of a Liver Transplant Patient-derived Tumor Xenograft (PDX) Model Using Cryopreserved Pancreatic Ductal Adenocarcinoma Reviewed

    Tanaka Ryota, Kageyama Ken, Kimura Kenjiro, Eguchi Shinpei, Tauchi Jun, Shinkawa Hiroji, Ohira Go, Yamazoe Sadaaki, Yamamoto Akira, Tanaka Shogo, Amano Ryosuke, Tanaka Hiroaki, Yashiro Masakazu, Kubo Shoji, Ohira Masaichi

    ANTICANCER RESEARCH   40 ( 5 )   2637 - 2644   2020.05( ISSN:0250-7005

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    DOI: 10.21873/anticanres.14234

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  • Preoperative Neutrophil-to-lymphocyte Ratio Predicts Tumor-infiltrating CD8(+) T Cells in Biliary Tract Cancer Reviewed

    Tanaka Ryota, Kimura Kenjiro, Eguchi Shinpei, Tauchi Jun, Shibutani Masatune, Shinkawa Hiroji, Ohira Go, Yamazoe Sadaaki, Tanaka Shogo, Amano Ryosuke, Tanaka Hiroaki, Yashiro Masakazu, Kubo Shoji, Ohira Masaichi

    ANTICANCER RESEARCH   40 ( 5 )   2881 - 2887   2020.05( ISSN:0250-7005

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    DOI: 10.21873/anticanres.14264

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  • Establishment of a Liver Transplant Patient-derived Tumor Xenograft (PDX) Model Using Cryopreserved Pancreatic Ductal Adenocarcinoma. Reviewed

    Tanaka R, Kageyama K, Kimura K, Eguchi S, Tauchi J, Shinkawa H, Ohira GO, Yamazoe S, Yamamoto A, Tanaka S, Amano R, Tanaka H, Yashiro M, Kubo S, Ohira M

    Anticancer research   40 ( 5 )   2637 - 2644   2020.05( ISSN:0250-7005

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    DOI: 10.21873/anticanres.14234

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  • Preoperative Neutrophil-to-lymphocyte Ratio Predicts Tumor-infiltrating CD8(+) T Cells in Biliary Tract Cancer. Reviewed

    Tanaka R, Kimura K, Eguchi S, Tauchi J, Shibutani M, Shinkawa H, Ohira GO, Yamazoe S, Tanaka S, Amano R, Tanaka H, Yashiro M, Kubo S, Ohira M

    Anticancer research   40 ( 5 )   2881 - 2887   2020.05( ISSN:0250-7005

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    DOI: 10.21873/anticanres.14264

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  • Adaptive RSK-EphA2-GPRC5A signaling switch triggers chemotherapy resistance in ovarian cancer. Reviewed

    Moyano-Galceran L, Pietilä EA, Turunen SP, Corvigno S, Hjerpe E, Bulanova D, Joneborg U, Alkasalias T, Miki Y, Yashiro M, Chernenko A, Jukonen J, Singh M, Dahlstrand H, Carlson JW, Lehti K

    EMBO molecular medicine   12 ( 4 )   e11177   2020.04( ISSN:1757-4676

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    DOI: 10.15252/emmm.201911177

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  • 症例 横行結腸癌術後Sister Mary Josephʼs noduleの1例 Reviewed

    伊藤 厳太郎, 大澤 尚志, 永原 央, 八代 正和, 大平 雅一

    外科   82 ( 4 )   376 - 380   2020.04( ISSN:0016593X ( eISSN:24329428

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    DOI: 10.15106/j_geka82_376

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  • 横行結腸癌術後Sister Mary Joseph&#700;s noduleの1例 Reviewed

    伊藤 厳太郎, 大澤 尚志, 永原 央, 八代 正和, 大平 雅一

    (株)南江堂 外科   82 ( 4 )   376 - 380   2020.04( ISSN:0016-593X

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    79歳女性。横行結腸癌術後10ヵ月目に臍部痛と臍部腫瘍が触知され、精査加療目的で入院となった。所見ではCEAの上昇が認められ、腹部超音波検査では低エコーを示す腫瘍がみられ、転移が疑われた。また、腹部造影CTでは造影効果を示す臍部に皮下組織から腹膜に至る33×32mmの辺縁不整な腫瘍が確認され、PET/CTでは臍部に強い集積が認められた。以上より、本症例は横行結腸癌術後の異時性孤立臍転移と診断され、臍腫瘍切除術が施行された。その結果、臍部痛は消失し、病理組織学的には横行結腸癌術後のSister Mary Joseph's noduleと確定診断された。退院後はUFT/UZELによる化学療法が行われたが、術後7ヵ月より肝転移が出現し、best supportive careへ移行されたものの、肝転移の増大や癌性腹水、悪液質の進行を認め、臍転移切除術後24ヵ月目に死亡となった。

  • 横行結腸癌術後Sister Mary Joseph&#700;s noduleの1例 Reviewed

    伊藤 厳太郎, 大澤 尚志, 永原 央, 八代 正和, 大平 雅一

    外科   82 ( 4 )   376 - 380   2020.04( ISSN:0016-593X

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    79歳女性。横行結腸癌術後10ヵ月目に臍部痛と臍部腫瘍が触知され、精査加療目的で入院となった。所見ではCEAの上昇が認められ、腹部超音波検査では低エコーを示す腫瘍がみられ、転移が疑われた。また、腹部造影CTでは造影効果を示す臍部に皮下組織から腹膜に至る33×32mmの辺縁不整な腫瘍が確認され、PET/CTでは臍部に強い集積が認められた。以上より、本症例は横行結腸癌術後の異時性孤立臍転移と診断され、臍腫瘍切除術が施行された。その結果、臍部痛は消失し、病理組織学的には横行結腸癌術後のSister Mary Joseph's noduleと確定診断された。退院後はUFT/UZELによる化学療法が行われたが、術後7ヵ月より肝転移が出現し、best supportive careへ移行されたものの、肝転移の増大や癌性腹水、悪液質の進行を認め、臍転移切除術後24ヵ月目に死亡となった。

  • Adaptive RSK-EphA2-GPRC5A signaling switch triggers chemotherapy resistance in ovarian cancer. Reviewed

    Moyano-Galceran L, Pietilä EA, Turunen SP, Corvigno S, Hjerpe E, Bulanova D, Joneborg U, Alkasalias T, Miki Y, Yashiro M, Chernenko A, Jukonen J, Singh M, Dahlstrand H, Carlson JW, Lehti K

    EMBO molecular medicine   e11177   2020.03( ISSN:1757-4676

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    DOI: 10.15252/emmm.201911177

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  • スキルス胃癌細胞由来の細胞外小胞は癌関連線維芽細胞の増殖を促進する(Exosomes from Scirrhous Gastric Cancer Cells promote proliferation of Cancer-associated Fibroblasts) Reviewed

    杉本 敦史, 八代 正和, 奥野 倫久, 三木 友一郎, 山本 百合恵, 瀬良 知央, 櫛山 周平, 西村 貞徳, 黒田 顕慈, 田中 涼太, 栂野 真吾, 大平 雅一

    日本胃癌学会総会記事   92回   270 - 270   2020.03

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  • 胃癌におけるCXCR2リガンドファミリー発現の臨床学的意義(The Clinicopathological Significance of CXCR2 Ligands in Gastric Cancer) Reviewed

    山本 百合恵, 八代 正和, 瀬良 知央, 櫛谷 友佳子, 杉本 敦史, 櫛山 周平, 西村 貞徳, 黒田 顕慈, 栂野 真吾, 奥野 倫久, 田村 達郎, 豊川 貴弘, 田中 浩明, 六車 一哉, 大平 雅一

    日本胃癌学会総会記事   92回   269 - 269   2020.03

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  • Expansion part of phase I study of E7090 in patients with cholangiocarcinoma harboring FGFR2 gene fusion and with gastric cancer harboring FGFR2 gene amplification or FGFR2 protein high expression Reviewed

    Morizane Chigusa, Ueno Makoto, Ioka Tatsuya, Tajika Masahiro, Ikeda Masafumi, Yamaguchi Kensei, Hara Hiroki, Yabusaki Hiroshi, Miyamoto Atsushi, Iwasa Satoru, Muto Manabu, Takashima Tsutomu, Minashi Keiko, Komatsu Yoshito, Nishina Tomohiro, Nakajima Takako Eguchi, Sahara Takatoshi, Funasaka Setsuo, Yashiro Masakazu, Furuse Junji

    JOURNAL OF CLINICAL ONCOLOGY   38 ( 4 )   2020.02( ISSN:0732-183X

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  • A Giant Gastric Gastrointestinal Stromal Tumor Successfully Resected Following Neoadjuvant Treatment With Imatinib Mesylate. Reviewed

    Takahashi R, Toyokawa T, Yoshii M, Tamura T, Tanaka H, Lee S, Muguruma K, Yashiro M, Ohira M

    Anticancer research   40 ( 2 )   1147 - 1152   2020.02( ISSN:0250-7005

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    DOI: 10.21873/anticanres.14056

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  • Generation of Rat Monoclonal Antibodies Specific for Human Stromal Cell-Derived Factor-2. Reviewed

    Tanaka M, Shiota M, Koyama M, Nakayama J, Yashiro M, Semba K, Goda N

    Monoclonal antibodies in immunodiagnosis and immunotherapy   39 ( 1 )   23 - 26   2020.02

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    DOI: 10.1089/mab.2019.0043

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  • Generation of Rat Monoclonal Antibodies Specific for Human Stromal Cell-Derived Factor-2. Reviewed

    Tanaka M, Shiota M, Koyama M, Nakayama J, Yashiro M, Semba K, Goda N

    Monoclonal antibodies in immunodiagnosis and immunotherapy   39 ( 1 )   23 - 26   2020.02

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    DOI: 10.1089/mab.2019.0043

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  • A Giant Gastric Gastrointestinal Stromal Tumor Successfully Resected Following Neoadjuvant Treatment With Imatinib Mesylate. Reviewed

    Takahashi R, Toyokawa T, Yoshii M, Tamura T, Tanaka H, Lee S, Muguruma K, Yashiro M, Ohira M

    Anticancer research   40 ( 2 )   1147 - 1152   2020.02( ISSN:0250-7005

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    DOI: 10.21873/anticanres.14056

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  • Precision medicine for gastrointestinal cancer: Recent progress and future perspective. Reviewed

    Matsuoka T, Yashiro M

    World journal of gastrointestinal oncology   12 ( 1 )   1 - 20   2020.01

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    DOI: 10.4251/wjgo.v12.i1.1

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  • Precision medicine for gastrointestinal cancer: Recent progress and future perspective. Reviewed

    Matsuoka T, Yashiro M

    World journal of gastrointestinal oncology   12 ( 1 )   1 - 20   2020.01( ISSN:1948-5204

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    DOI: 10.4251/wjgo.v12.i1.1

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  • Epigenetic priming sensitizes gastric cancer cells to irinotecan and cisplatin by restoring multiple pathways Reviewed

    Moro Hiroshi, Hattori Naoko, Nakamura Yoshiaki, Kimura Kana, Imai Toshio, Maeda Masahiro, Yashiro Masakazu, Ushijima Toshikazu

    GASTRIC CANCER   23 ( 1 )   105 - 115   2020.01( ISSN:1436-3291

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    DOI: 10.1007/s10120-019-01010-1

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  • Gastric cancer cells alter the immunosuppressive function of neutrophils Reviewed

    Hiramatsu Soichiro, Tanaka Hiroaki, Nishimura Junya, Yamakoshi Yoshihito, Sakimura Chie, Tamura Tatsuro, Toyokawa Takahiro, Muguruma Kazuya, Yashiro Masakazu, Hirakawa Kosei, Ohira Masaichi

    ONCOLOGY REPORTS   43 ( 1 )   251 - 259   2020.01( ISSN:1021-335X

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    DOI: 10.3892/or.2019.7410

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  • Epigenetic priming sensitizes gastric cancer cells to irinotecan and cisplatin by restoring multiple pathways(和訳中) Reviewed

    Moro Hiroshi, Hattori Naoko, Nakamura Yoshiaki, Kimura Kana, Imai Toshio, Maeda Masahiro, Yashiro Masakazu, Ushijima Toshikazu

    シュプリンガー・ジャパン(株) Gastric Cancer   23 ( 1 )   105 - 115   2020.01( ISSN:1436-3291

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  • Epigenetic priming sensitizes gastric cancer cells to irinotecan and cisplatin by restoring multiple pathways (vol 12, pg 289, 2019) Reviewed

    Moro Hiroshi, Hattori Naoko, Nakamura Yoshiaki, Kimura Kana, Imai Toshio, Maeda Masahiro, Yashiro Masakazu, Ushijima Toshikazu

    GASTRIC CANCER   23 ( 1 )   116 - 117   2020.01( ISSN:1436-3291

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    DOI: 10.1007/s10120-019-01013-y

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  • Epigenetic priming sensitizes gastric cancer cells to irinotecan and cisplatin by restoring multiple pathways. Reviewed

    Moro H, Hattori N, Nakamura Y, Kimura K, Imai T, Maeda M, Yashiro M, Ushijima T

    Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association   23 ( 1 )   105 - 115   2020.01( ISSN:1436-3291

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    DOI: 10.1007/s10120-019-01010-1

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  • Gastric cancer cells alter the immunosuppressive function of neutrophils. Reviewed

    Hiramatsu S, Tanaka H, Nishimura J, Yamakoshi Y, Sakimura C, Tamura T, Toyokawa T, Muguruma K, Yashiro M, Hirakawa K, Ohira M

    Oncology reports   43 ( 1 )   251 - 259   2020.01( ISSN:1021-335X

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    DOI: 10.3892/or.2019.7410

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  • Correction to: Epigenetic priming sensitizes gastric cancer cells to irinotecan and cisplatin by restoring multiple pathways. Reviewed

    Moro H, Hattori N, Nakamura Y, Kimura K, Imai T, Maeda M, Yashiro M, Ushijima T

    Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association   23 ( 1 )   116 - 117   2020.01( ISSN:1436-3291

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    DOI: 10.1007/s10120-019-01013-y

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  • エピジェネティックなプライミングにより胃癌細胞は複数の経路を回復させそのことでイリノテカンおよびシスプラチンに対し感受性を示すようになる(Epigenetic priming sensitizes gastric cancer cells to irinotecan and cisplatin by restoring multiple pathways) Reviewed

    Moro Hiroshi, Hattori Naoko, Nakamura Yoshiaki, Kimura Kana, Imai Toshio, Maeda Masahiro, Yashiro Masakazu, Ushijima Toshikazu

    Gastric Cancer   23 ( 1 )   105 - 115   2020.01( ISSN:1436-3291

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    DNA脱メチル化剤である5-アザ-2'-デオキシシチジン(5-aza-dC)を胃癌細胞に作用させることで、臨床的に用いられている細胞毒性剤に対する感受性が付与されるか解析した。各種の胃癌細胞株を対象に、感受性試験を行った結果、SN38(イリノテカンの活性型代謝産物)、シスプラチン、パクリタキセル、5-FUのそれぞれに耐性を示す胃癌細胞株を同定した。それらの耐性細胞株を5-aza-dCで72時間処理してその増殖を評価したところ、SN38耐性株とシスプラチン耐性株では50%阻害濃度(IC50)が低下したが、パクリタキセル耐性株と5-FU耐性株では低下しなかった。5-aza-dCでの前処理によってアポトーシス関連遺伝子類が再活性化され、そのうちの2種の遺伝子ではプロモーター領域のCpGアイランドのDNAが脱メチル化されたことが確かめられた。SN38耐性胃癌細胞株を皮下異種移植したマウスモデルをイリノテカンで治療する実験系において、イリノテカン治療前に5-aza-dCを腹腔内投与したところ腫瘍抑制効果は著明に亢進した。5-aza-dCを用いてエピジェネティックにプライミングを行えば、胃癌細胞のSN38およびシスプラチンへの感受性を向上させられることが明らかになった。

  • Microscopic distance from tumor invasion front to serosa might be a useful predictive factor for peritoneal recurrence after curative resection of T3-gastric cancer. Reviewed

    Togano S, Yashiro M, Miki Y, Yamamato Y, Sera T, Kushitani Y, Sugimoto A, Kushiyama S, Nishimura S, Kuroda K, Okuno T, Yoshii M, Tamura T, Toyokawa T, Tanaka H, Muguruma K, Tanaka S, Ohira M

    PloS one   15 ( 1 )   e0225958   2020

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    DOI: 10.1371/journal.pone.0225958

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  • Correction: Microscopic distance from tumor invasion front to serosa might be a useful predictive factor for peritoneal recurrence after curative resection of T3-gastric cancer. Reviewed

    Togano S, Yashiro M, Miki Y, Yamamoto Y, Sera T, Kushitani Y, Sugimoto A, Kushiyama S, Nishimura S, Kuroda K, Okuno T, Yoshii M, Tamura T, Toyokawa T, Tanaka H, Muguruma K, Tanaka S, Ohira M

    PloS one   15 ( 5 )   e0233743   2020

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    DOI: 10.1371/journal.pone.0233743

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  • Microscopic distance from tumor invasion front to serosa might be a useful predictive factor for peritoneal recurrence after curative resection of T3-gastric cancer. Reviewed

    Togano S, Yashiro M, Miki Y, Yamamoto Y, Sera T, Kushitani Y, Sugimoto A, Kushiyama S, Nishimura S, Kuroda K, Okuno T, Yoshii M, Tamura T, Toyokawa T, Tanaka H, Muguruma K, Tanaka S, Ohira M

    PloS one   15 ( 1 )   e0225958   2020

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    DOI: 10.1371/journal.pone.0225958

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  • Cancer cells with high-metastatic potential promote a glycolytic shift in activated fibroblasts. Reviewed

    Kogure A, Naito Y, Yamamoto Y, Yashiro M, Kiyono T, Yanagihara K, Hirakawa K, Ochiya T

    PloS one   15 ( 6 )   e0234613   2020

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    DOI: 10.1371/journal.pone.0234613

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  • Crosstalk Between Cancer Associated Fibroblasts and Cancer Cells in Scirrhous Type Gastric Cancer. Reviewed

    Miki Y, Yashiro M, Moyano-Galceran L, Sugimoto A, Ohira M, Lehti K

    Frontiers in oncology   10   568557   2020( ISSN:2234-943X

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    DOI: 10.3389/fonc.2020.568557

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  • Correction: Microscopic distance from tumor invasion front to serosa might be a useful predictive factor for peritoneal recurrence after curative resection of T3-gastric cancer. Reviewed

    Shingo Togano, Masakazu Yashiro, Yuichiro Miki, Yurie Yamamoto, Tomohiro Sera, Yukako Kushitani, Atsushi Sugimoto, Shuhei Kushiyama, Sadaaki Nishimura, Kenji Kuroda, Tomohisa Okuno, Mami Yoshii, Tatsuro Tamura, Takahiro Toyokawa, Hiroaki Tanaka, Kazuya Muguruma, Sayaka Tanaka, Masaichi Ohira

    PloS one   15 ( 5 )   e0233743   2020

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    [This corrects the article DOI: 10.1371/journal.pone.0225958.].

    DOI: 10.1371/journal.pone.0233743

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  • The Clinicopathological Significance of the CXCR2 Ligands, CXCL1, CXCL2, CXCL3, CXCL5, CXCL6, CXCL7, and CXCL8 in Gastric Cancer. Reviewed

    Yamamoto Y, Kuroda K, Sera T, Sugimoto A, Kushiyama S, Nishimura S, Togano S, Okuno T, Yoshii M, Tamura T, Toyokawa T, Tanaka H, Muguruma K, Ohira M, Yashiro M

    Anticancer research   39 ( 12 )   6645 - 6652   2019.12( ISSN:0250-7005

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    DOI: 10.21873/anticanres.13879

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  • The Clinicopathological Significance of the CXCR2 Ligands, CXCL1, CXCL2, CXCL3, CXCL5, CXCL6, CXCL7, and CXCL8 in Gastric Cancer. Reviewed

    Yamamoto Y, Kuroda K, Sera T, Sugimoto A, Kushiyama S, Nishimura S, Togano S, Okuno T, Yoshii M, Tamura T, Toyokawa T, Tanaka H, Muguruma K, Ohira M, Yashiro M

    Anticancer research   39 ( 12 )   6645 - 6652   2019.12( ISSN:0250-7005

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    DOI: 10.21873/anticanres.13879

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  • High tissue MMP14 expression predicts worse survival in gastric cancer, particularly with a low PROX1 Reviewed

    Kasurinen Aaro, Gramolelli Silvia, Hagstrom Jaana, Laitinen Alli, Kokkola Arto, Miki Yuichiro, Lehti Kaisa, Yashiro Masakazu, Ojala Paivi M., Bockelman Camilla, Haglund Caj

    CANCER MEDICINE   8 ( 16 )   6995 - 7005   2019.11( ISSN:2045-7634

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    DOI: 10.1002/cam4.2576

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  • High tissue MMP14 expression predicts worse survival in gastric cancer, particularly with a low PROX1. Reviewed

    Kasurinen A, Gramolelli S, Hagström J, Laitinen A, Kokkola A, Miki Y, Lehti K, Yashiro M, Ojala PM, Böckelman C, Haglund C

    Cancer medicine   8 ( 16 )   6995 - 7005   2019.11

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    DOI: 10.1002/cam4.2576

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  • T3胃癌におけるE-cadherinおよび癌先進部漿膜間距離と腹膜播種再発との関連性 Reviewed

    栂野 真吾, 八代 正和, 黒田 顕慈, 奥野 倫久, 西村 貞徳, 櫛山 周平, 三木 友一朗, 田村 達郎, 豊川 貴弘, 田中 浩明, 六車 一哉, 大平 雅一

    日本癌治療学会学術集会抄録集   57回   P11 - 7   2019.10

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  • 胃癌におけるFibroblast Growth Factor Receptor 2発現の臨床病理学的意義 Reviewed

    黒田 顕慈, 八代 正和, 増田 剛, 杉本 敦史, 瀬良 知央, 櫛谷 友佳子, 櫛山 周平, 西村 貞徳, 栂野 真吾, 奥野 倫久, 豊川 貴弘, 田中 浩明, 六車 一哉, 大平 雅一

    日本癌治療学会学術集会抄録集   57回   O6 - 4   2019.10

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  • Feasibility of Identifying Patients at High Risk of Hereditary Gastric Cancer Based on Clinicopathological Variables Reviewed

    Nishimura Sadaaki, Yashiro Masakazu, Sera Tomohiro, Yamamoto Yurie, Kushitani Yukako, Sugimoto Atsushi, Kushiyama Shuhei, Kuroda Kenji, Togano Shingo, Okuno Tomohisa, Tamura Tatsuro, Toyokawa Takahiro, Tanaka Hiroaki, Muguruma Kazuya, Hirakawa Kosei, Ohira Masaichi

    ANTICANCER RESEARCH   39 ( 9 )   5057 - 5064   2019.09( ISSN:0250-7005

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    DOI: 10.21873/anticanres.13698

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  • Feasibility of Identifying Patients at High Risk of Hereditary Gastric Cancer Based on Clinicopathological Variables. Reviewed

    Nishimura S, Yashiro M, Sera T, Yamamoto Y, Kushitani Y, Sugimoto A, Kushiyama S, Kuroda K, Togano S, Okuno T, Tamura T, Toyokawa T, Tanaka H, Muguruma K, Hirakawa K, Ohira M

    Anticancer research   39 ( 9 )   5057 - 5064   2019.09( ISSN:0250-7005

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    DOI: 10.21873/anticanres.13698

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  • スキルス胃癌と癌関連線維芽細胞の相互作用(Heterogeneous interactions between scirrhous gastric cancer cells and cancer-associated fibroblasts) Reviewed

    櫛山 周平, 八代 正和, 山本 百合恵, 黒田 顕慈, 栂野 真吾, 西村 貞徳, 櫛谷 友佳子, 杉本 敦史, 瀬良 知央, 大平 雅一

    日本癌学会総会記事   78回   P - 2286   2019.09( ISSN:0546-0476

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  • 胃癌間質におけるThrombospondin 4発現の臨床病理学的検討(Clinicopathological Significance of Thrombospondin 4 Expression in Gastric Cancer Stroma) Reviewed

    黒田 顕慈, 八代 正和, 栂野 真吾, 櫛山 周平, 西村 貞徳, 杉本 敦史, 瀬良 知央, 櫛谷 友佳子, 山本 百合恵, 豊川 貴弘, 田中 浩明, 六車 一哉, 大平 雅一

    日本癌学会総会記事   78回   P - 1113   2019.09( ISSN:0546-0476

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  • ストレス下における胃癌幹細胞とオートファジーの関連性(The correlation between gastric cancer stem cells under stress and autophagy system) Reviewed

    栂野 真吾, 八代 正和, 増田 剛, 山本 百合恵, 櫛山 周平, 西村 貞徳, 黒田 顕慈, 奥野 倫久, 三木 友一朗, 平川 弘聖, 大平 雅一

    日本癌学会総会記事   78回   P - 3262   2019.09( ISSN:0546-0476

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  • スキルス胃癌におけるマルチプレックス遺伝子パネル検査の有用性(Feasibility of multiplex gene panel testing to scirrhous gastric cancer) Reviewed

    西村 貞徳, 八代 正和, 瀬良 知央, 櫛谷 友佳子, 杉本 敦史, 櫛山 周平, 栂野 真吾, 黒田 顕慈, 田村 達郎, 豊川 貴弘, 田中 浩明, 六車 一哉, 大平 雅一

    日本癌学会総会記事   78回   J - 2030   2019.09( ISSN:0546-0476

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  • Induction of Trop-2 expression through the binding of galectin-3 to MUC1 Reviewed

    Yamashita Tomoko, Mori Yugo, Alzaaqi Shouq M., Yashiro Masakazu, Sawada Tetsuji, Hirakawa Kosei, Nakada Hiroshi

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   516 ( 1 )   44 - 49   2019.08( ISSN:0006-291X

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    DOI: 10.1016/j.bbrc.2019.06.003

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  • Induction of Trop-2 expression through the binding of galectin-3 to MUC1. Reviewed

    Yamashita T, Mori Y, Alzaaqi SM, Yashiro M, Sawada T, Hirakawa K, Nakada H

    Biochemical and biophysical research communications   516 ( 1 )   44 - 49   2019.08( ISSN:0006-291X

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    DOI: 10.1016/j.bbrc.2019.06.003

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  • 症例 腹腔鏡下胆囊摘出術中に胆囊底部に認めた異所性肝の1例 Reviewed

    伊藤 厳太郎, 八代 正和, 山添 定明, 木村 健二郎, 天野 良亮, 大平 雅一

    外科   81 ( 9 )   999 - 1002   2019.08( ISSN:0016593X ( eISSN:24329428

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    DOI: 10.15106/j_geka81_999

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  • [A Case of Lymph Node Recurrence Seven Years after Curative Esophagectomy for T1a(LPM)Upper Thoracic Esophageal Cancer]. Reviewed

    Sasaki M, Tamura T, Toyokawa T, Sakurai K, Amano R, Kubo N, Tanaka H, Muguruma K, Yashiro M, Ohira M

    Gan to kagaku ryoho. Cancer & chemotherapy   46 ( 8 )   1295 - 1297   2019.08( ISSN:0385-0684

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    PubMed

  • Identification of candidates for driver oncogenes in scirrhous-type gastric cancer cell lines Reviewed

    Sai Eirin, Miwa Yoshiyuki, Takeyama Reina, Kojima Shinya, Ueno Toshihide, Yashiro Masakazu, Seto Yasuyuki, Mano Hiroyuki

    CANCER SCIENCE   110 ( 8 )   2643 - 2651   2019.08( ISSN:1347-9032

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    DOI: 10.1111/cas.14111

    PubMed

  • スキルス胃癌細胞株における発癌ドライバー遺伝子の候補の同定(Identification of candidates for driver oncogenes in scirrhous-type gastric cancer cell lines) Reviewed

    Sai Eirin, Miwa Yoshiyuki, Takeyama Reina, Kojima Shinya, Ueno Toshihide, Yashiro Masakazu, Seto Yasuyuki, Mano Hiroyuki

    John Wiley & Sons Australia, Ltd Cancer Science   110 ( 8 )   2643 - 2651   2019.08( ISSN:1347-9032

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    確立したスキルス胃癌細胞株2種に対し全エクソーム配列解析とRNA配列解析とを施行することでスキルス胃癌の発癌ドライバー遺伝子の新規候補を検索することを試みた。両細胞株で発見された突然変異の大部分は未報告のものであった。片方の細胞株ではCD44遺伝子とIGF1R遺伝子の新規融合遺伝子が発見され、ゲノム内でCD44遺伝子とIGF1R遺伝子とが著明に増幅され豊富に発現していた。さらに同融合遺伝子は形質転換能を有することが細胞株を用いたフォーカス形成アッセイとマウスでの腫瘍形成アッセイで示された。もう片方の細胞株はゲノム中に複数の発癌イベントを所有していると思われる所見が得られ、中でも新規に見出されたBORCS5-ETV6融合遺伝子は発癌活性を有することが明らかになった。これらの新規融合遺伝子が実際のスキルス胃癌でも出現しているのかはこれから検討する必要があるものの、スキルス胃癌の詳細なゲノム解析を行うための被検物として細胞株は重要であることが確認された。

  • 腹腔鏡下胆嚢摘出術中に胆嚢底部に認めた異所性肝の1例 Reviewed

    伊藤 厳太郎, 八代 正和, 山添 定明, 木村 健二郎, 天野 良亮, 大平 雅一

    (株)南江堂 外科   81 ( 9 )   999 - 1002   2019.08( ISSN:0016-593X

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    69歳女性。近医より心窩部痛の精査目的で当院へ紹介となった。腹部CTおよび超音波所見より胆嚢結石と診断され、腹腔鏡下胆嚢摘出術を施行したところ、胆嚢底部に付着する約15mmの結節を認めたため胆嚢とともに切除した。病理組織学的に胆嚢底部に生じた異所性肝と診断され、術後は経過良好で術後7日目に退院となった。

  • 根治術後7年目に左鎖骨上リンパ節再発を来した胸部食道T1a(LPM)癌の1例 Reviewed

    佐々木 麻帆, 田村 達郎, 豊川 貴弘, 櫻井 克宣, 天野 良亮, 久保 尚士, 田中 浩明, 六車 一哉, 八代 正和, 大平 雅一

    (株)癌と化学療法社 癌と化学療法   46 ( 8 )   1295 - 1297   2019.08( ISSN:0385-0684

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    食道癌根治手術後の再発は28〜47%、その約85%が2年以内の早期に認められ、再発診断時からの生存期間中央値は5〜10ヵ月と極めて不良である。一方、壁深達度T1a(MM)、T1b(SM1)の症例でのリンパ節転移は10〜20%であることが知られており多くは手術治療が行われるが、T1a(LPM)ではリンパ節転移の頻度は極めてまれである。今回われわれは、pT1a(LPM)の食道癌根治術後7年という長期経過後に左鎖骨上リンパ節(No.104L)に再発したまれな症例を経験したので文献的考察を加えて報告する。(著者抄録)

  • Identification of candidates for driver oncogenes in scirrhous-type gastric cancer cell lines. Reviewed

    Sai E, Miwa Y, Takeyama R, Kojima S, Ueno T, Yashiro M, Seto Y, Mano H

    Cancer science   110 ( 8 )   2643 - 2651   2019.08( ISSN:1347-9032

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/cas.14111

    PubMed

  • [A Case of Lymph Node Recurrence Seven Years after Curative Esophagectomy for T1a(LPM)Upper Thoracic Esophageal Cancer]. Reviewed

    Sasaki M, Tamura T, Toyokawa T, Sakurai K, Amano R, Kubo N, Tanaka H, Muguruma K, Yashiro M, Ohira M

    Gan to kagaku ryoho. Cancer & chemotherapy   46 ( 8 )   1295 - 1297   2019.08( ISSN:0385-0684

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    Publishing type:Research paper (scientific journal)  

    PubMed

  • スキルス胃癌細胞株における発癌ドライバー遺伝子の候補の同定(Identification of candidates for driver oncogenes in scirrhous-type gastric cancer cell lines) Reviewed

    Sai Eirin, Miwa Yoshiyuki, Takeyama Reina, Kojima Shinya, Ueno Toshihide, Yashiro Masakazu, Seto Yasuyuki, Mano Hiroyuki

    Cancer Science   110 ( 8 )   2643 - 2651   2019.08( ISSN:1347-9032

     More details

    Publishing type:Research paper (scientific journal)  

    確立したスキルス胃癌細胞株2種に対し全エクソーム配列解析とRNA配列解析とを施行することでスキルス胃癌の発癌ドライバー遺伝子の新規候補を検索することを試みた。両細胞株で発見された突然変異の大部分は未報告のものであった。片方の細胞株ではCD44遺伝子とIGF1R遺伝子の新規融合遺伝子が発見され、ゲノム内でCD44遺伝子とIGF1R遺伝子とが著明に増幅され豊富に発現していた。さらに同融合遺伝子は形質転換能を有することが細胞株を用いたフォーカス形成アッセイとマウスでの腫瘍形成アッセイで示された。もう片方の細胞株はゲノム中に複数の発癌イベントを所有していると思われる所見が得られ、中でも新規に見出されたBORCS5-ETV6融合遺伝子は発癌活性を有することが明らかになった。これらの新規融合遺伝子が実際のスキルス胃癌でも出現しているのかはこれから検討する必要があるものの、スキルス胃癌の詳細なゲノム解析を行うための被検物として細胞株は重要であることが確認された。

  • 根治術後7年目に左鎖骨上リンパ節再発を来した胸部食道T1a(LPM)癌の1例 Reviewed

    佐々木 麻帆, 田村 達郎, 豊川 貴弘, 櫻井 克宣, 天野 良亮, 久保 尚士, 田中 浩明, 六車 一哉, 八代 正和, 大平 雅一

    癌と化学療法   46 ( 8 )   1295 - 1297   2019.08( ISSN:0385-0684

     More details

    Publishing type:Research paper (scientific journal)  

    食道癌根治手術後の再発は28~47%、その約85%が2年以内の早期に認められ、再発診断時からの生存期間中央値は5~10ヵ月と極めて不良である。一方、壁深達度T1a(MM)、T1b(SM1)の症例でのリンパ節転移は10~20%であることが知られており多くは手術治療が行われるが、T1a(LPM)ではリンパ節転移の頻度は極めてまれである。今回われわれは、pT1a(LPM)の食道癌根治術後7年という長期経過後に左鎖骨上リンパ節(No.104L)に再発したまれな症例を経験したので文献的考察を加えて報告する。(著者抄録)

  • 腹腔鏡下胆嚢摘出術中に胆嚢底部に認めた異所性肝の1例 Reviewed

    伊藤 厳太郎, 八代 正和, 山添 定明, 木村 健二郎, 天野 良亮, 大平 雅一

    外科   81 ( 9 )   999 - 1002   2019.08( ISSN:0016-593X

     More details

    Publishing type:Research paper (scientific journal)  

    69歳女性。近医より心窩部痛の精査目的で当院へ紹介となった。腹部CTおよび超音波所見より胆嚢結石と診断され、腹腔鏡下胆嚢摘出術を施行したところ、胆嚢底部に付着する約15mmの結節を認めたため胆嚢とともに切除した。病理組織学的に胆嚢底部に生じた異所性肝と診断され、術後は経過良好で術後7日目に退院となった。

  • Cancer extracellular vesicles contribute to stromal heterogeneity by inducing chemokines in cancer-associated fibroblasts Reviewed

    Naito Yutaka, Yamamoto Yusuke, Sakamoto Naoya, Shimomura Iwao, Kogure Akiko, Kumazaki Minami, Yokoi Akira, Yashiro Masakazu, Kiyono Tohru, Yanagihara Kazuyoshi, Takahashi Ryou-u, Hirakawa Kosei, Yasui Wataru, Ochiya Takahiro

    ONCOGENE   38 ( 28 )   5566 - 5579   2019.07( ISSN:0950-9232

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    DOI: 10.1038/s41388-019-0832-4

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  • Bone marrow-derived stromal cells in the tumor microenvironment might be associated with the progression of gastric cancer Reviewed

    Yashiro Masakazu, Kasashima Hiroaki, Kushiyama Syuhei, Nishimura Sadaaki, Kuroda Kenji, Togano Shingo, Okuno Tomohisa, Miki Yuichiro, Fukuoka Tatsunari, Nakamae Hirohisa, Hino Masayuki, Ohira Masaichi

    CANCER RESEARCH   79 ( 13 )   2019.07( ISSN:0008-5472

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    DOI: 10.1158/1538-7445.AM2019-2742

  • A factor (> MR 30 kDa) from cancer-associated fibroblasts may stimulate the progression of schirrous gastric cancer without FGFR2 overexpression Reviewed

    Kushiyama Syuhei, Yashiro Masakazu, Okuno Tomohisa, Kuroda Kenji, Tanaka Ryota, Togano Shingo, Nishimura Sadaaki, Toyokawa Takahiro, Tanaka Hiroaki, Muguruma Kazuya, Hirakawa Kosei, Ohira Masaichi

    CANCER RESEARCH   79 ( 13 )   2019.07( ISSN:0008-5472

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    DOI: 10.1158/1538-7445.AM2019-2045

  • Effect of cancer-associated fibroblasts on lymphatic vessel formation in malignant melanoma Reviewed

    Maeda Shusaku, Yashiro Masakazu, Motomura Hisashi, Hatano Takaharu, Fujikawa Heishiro

    CANCER RESEARCH   79 ( 13 )   2019.07( ISSN:0008-5472

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    DOI: 10.1158/1538-7445.AM2019-3763

  • Extracellular vesicles from scirrhous gastric cancer cells induce premetastatic niche formation for peritoneal metastasis Reviewed

    Okuno Tomohisa, Yashiro Masakazu, Kushiyama Shuhei, Nishimura Sadaaki, Togano Shingo, Kuroda Kenji, Tamura Tatsuro, Toyokawa Takahiro, Tanaka Hiroaki, Muguruma Kazuya, Hirakawa Kosei, Ohira Masaichi

    CANCER RESEARCH   79 ( 13 )   2019.07( ISSN:0008-5472

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    DOI: 10.1158/1538-7445.SABCS18-5160

  • p53 expression is a useful predictive marker for recurrence of meningioma Reviewed

    Nagahama Atsufumi, Yashiro Masakazu, Miki Yuichiro, Morisako Hiroki, Uda Takehiro, Goto Takeo, Takami Takehiro, Ohata Kenji

    CANCER RESEARCH   79 ( 13 )   2019.07( ISSN:0008-5472

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    DOI: 10.1158/1538-7445.AM2019-4901

  • Macrophage Inflammatory Protein-3 beta (MIP-3 beta) from cancer-associated fibroblasts promote the proliferation of melanoma cells Reviewed

    Fujikawa Heishiro, Yashiro Masakazu, Hatano Takaharu, Maeda Shusaku, Motomura Hisashi

    CANCER RESEARCH   79 ( 13 )   2019.07( ISSN:0008-5472

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    DOI: 10.1158/1538-7445.AM2019-2037

  • Long-term survival estimates in older patients with pathological stage I gastric cancer undergoing gastrectomy: Duocentric analysis of simplified scoring system Reviewed

    Sakurai Katsunobu, Kubo Naoshi, Tamamori Yutaka, Tamura Tatsuro, Toyokawa Takahiro, Tanaka Hiroaki, Muguruma Kazuya, Yashiro Masakazu, Maeda Kiyoshi, Nishiguchi Yukio, Hirakawa Kosei, Ohira Masaichi

    JOURNAL OF GERIATRIC ONCOLOGY   10 ( 4 )   604 - 609   2019.07( ISSN:1879-4068

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    DOI: 10.1016/j.jgo.2019.01.003

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  • Long-term survival estimates in older patients with pathological stage I gastric cancer undergoing gastrectomy: Duocentric analysis of simplified scoring system. Reviewed

    Sakurai K, Kubo N, Tamamori Y, Tamura T, Toyokawa T, Tanaka H, Muguruma K, Yashiro M, Maeda K, Nishiguchi Y, Hirakawa K, Ohira M

    Journal of geriatric oncology   10 ( 4 )   604 - 609   2019.07( ISSN:1879-4068

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    DOI: 10.1016/j.jgo.2019.01.003

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  • Cancer extracellular vesicles contribute to stromal heterogeneity by inducing chemokines in cancer-associated fibroblasts. Reviewed

    Naito Y, Yamamoto Y, Sakamoto N, Shimomura I, Kogure A, Kumazaki M, Yokoi A, Yashiro M, Kiyono T, Yanagihara K, Takahashi RU, Hirakawa K, Yasui W, Ochiya T

    Oncogene   38 ( 28 )   5566 - 5579   2019.07( ISSN:0950-9232

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    DOI: 10.1038/s41388-019-0832-4

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  • スキルス胃癌の増殖進展における癌細胞-間質線維芽細胞の相互作用に関わる新規シグナルの解析 Reviewed

    櫛山 周平, 八代 正和, 西村 貞徳, 栂野 真吾, 黒田 顕慈, 奥野 倫久, 福岡 達成, 大平 雅一

    日本消化器外科学会総会   74回   RS20 - 2   2019.07

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  • 胆道癌および膵癌における癌関連線維芽細胞の癌進展に及ぼす影響について Reviewed

    田中 涼太, 木村 健二郎, 天野 良亮, 山添 定明, 大平 豪, 田内 潤, 西村 貞徳, 田中 浩明, 八代 正和, 大平 雅一

    日本消化器外科学会総会   74回   P200 - 2   2019.07

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  • 胃癌におけるFGFR2陽性循環癌細胞(CTCs)測定の意義 Reviewed

    黒田 顕慈, 八代 正和, 三木 友一朗, 櫛山 周平, 西村 貞徳, 栂野 真吾, 奥野 倫久, 田中 浩明, 六車 一哉, 大平 雅一

    日本消化器外科学会総会   74回   P66 - 5   2019.07

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  • 癌ゲノム医療の二次的所見を推察する家族性胃癌の臨床病理学的特徴の検討 Reviewed

    西村 貞徳, 八代 正和, 櫛山 周平, 栂野 真吾, 黒田 顕慈, 奥野 倫久, 田中 浩明, 六車 一哉, 平川 弘聖, 大平 雅一

    日本消化器外科学会総会   74回   P68 - 7   2019.07

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  • 潜在型TGF-βは、胃癌患者における有望な予後良好のバイオマーカーとなりうる Reviewed

    栂野 真吾, 八代 正和, 櫛山 周平, 西村 貞徳, 黒田 顕慈, 奥野 倫久, 三木 友一朗, 村上 善基, 大平 雅一

    日本消化器外科学会総会   74回   P68 - 5   2019.07

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  • スキルス胃癌細胞の産生するextracellular vesiclesは腹膜中皮細胞の形態を制御し腹膜転移に関与する Reviewed

    奥野 倫久, 八代 正和, 櫛山 周平, 西村 貞徳, 栂野 真吾, 黒田 顕慈, 大平 雅一

    日本消化器外科学会総会   74回   O48 - 8   2019.07

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  • Postoperative Inflammation Is an Independent Prognostic Factor in Patients With Thoracic Esophageal Squamous Cell Carcinoma Reviewed

    Toyokawa Takahiro, Tamura Tatsuro, Sakurai Katsunobu, Kubo Naoshi, Tanaka Hiroaki, Muguruma Kazuya, Yashiro Masakazu, Ohira Masaichi

    ANTICANCER RESEARCH   39 ( 6 )   2777 - 2784   2019.06( ISSN:0250-7005

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    DOI: 10.21873/anticanres.13404

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  • Postoperative Inflammation Is an Independent Prognostic Factor in Patients With Thoracic Esophageal Squamous Cell Carcinoma. Reviewed

    Toyokawa T, Tamura T, Sakurai K, Kubo N, Tanaka H, Muguruma K, Yashiro M, Ohira M

    Anticancer research   39 ( 6 )   2777 - 2784   2019.06( ISSN:0250-7005

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    DOI: 10.21873/anticanres.13404

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  • [Efficacy and Safety of Paclitaxel plus Ramucirumab Therapy for Unresectable or Recurrent Gastric Cancer]. Reviewed

    Tsujio G, Toyokawa T, Fukuoka T, Tamura T, Ohira G, Shibutani M, Yamazoe S, Nagahara H, Kimura K, Amano R, Tanaka H, Muguruma K, Yashiro M, Maeda K, Hirakawa K, Ohira M

    Gan to kagaku ryoho. Cancer & chemotherapy   46 ( 5 )   895 - 899   2019.05( ISSN:0385-0684

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    PubMed

  • 切除不能進行・再発胃癌に対するPaclitaxel+Ramucirumab療法の治療成績 Reviewed

    辻尾 元, 豊川 貴弘, 福岡 達成, 田村 達郎, 大平 豪, 渋谷 雅常, 山添 定明, 永原 央, 木村 健二郎, 天野 良亮, 田中 浩明, 六車 一哉, 八代 正和, 前田 清, 平川 弘聖, 大平 雅一

    (株)癌と化学療法社 癌と化学療法   46 ( 5 )   895 - 899   2019.05( ISSN:0385-0684

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    進行・再発胃癌に対する二次以降の化学療法として施行したpaclitaxel(PTX)+ramucirumab(RAM)療法(PTX 80mg/m2、day 1、8、15、RAM 8mg/kg、day 1、15)の安全性および有効性について検討した。対象は当科でPTX+RAM療法を施行した進行・再発胃癌33例で、年齢中央値は68歳、PS2以上の症例は5例であった。投与コース数の中央値は4コースで、Grade 3以上の有害事象は28例(85%)[白血球・好中球減少21例(64%)、末梢神経障害3例(9%)など]に認められた。抗腫瘍効果は奏効率14.8%、病勢コントロール率66.7%であり、全生存期間および無増悪生存期間中央値はそれぞれ9.3ヵ月、4.7ヵ月であった。切除不能進行・再発胃癌に対するPTX+RAM療法は一定の効果が期待できるが、実地臨床においては高齢かつPSの悪い症例に対して使用することも多く、慎重なマネージメントが必要である。(著者抄録)

  • [Efficacy and Safety of Paclitaxel plus Ramucirumab Therapy for Unresectable or Recurrent Gastric Cancer]. Reviewed

    Tsujio G, Toyokawa T, Fukuoka T, Tamura T, Ohira G, Shibutani M, Yamazoe S, Nagahara H, Kimura K, Amano R, Tanaka H, Muguruma K, Yashiro M, Maeda K, Hirakawa K, Ohira M

    Gan to kagaku ryoho. Cancer & chemotherapy   46 ( 5 )   895 - 899   2019.05( ISSN:0385-0684

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    PubMed

  • 切除不能進行・再発胃癌に対するPaclitaxel+Ramucirumab療法の治療成績 Reviewed

    辻尾 元, 豊川 貴弘, 福岡 達成, 田村 達郎, 大平 豪, 渋谷 雅常, 山添 定明, 永原 央, 木村 健二郎, 天野 良亮, 田中 浩明, 六車 一哉, 八代 正和, 前田 清, 平川 弘聖, 大平 雅一

    癌と化学療法   46 ( 5 )   895 - 899   2019.05( ISSN:0385-0684

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    進行・再発胃癌に対する二次以降の化学療法として施行したpaclitaxel(PTX)+ramucirumab(RAM)療法(PTX 80mg/m2、day 1、8、15、RAM 8mg/kg、day 1、15)の安全性および有効性について検討した。対象は当科でPTX+RAM療法を施行した進行・再発胃癌33例で、年齢中央値は68歳、PS2以上の症例は5例であった。投与コース数の中央値は4コースで、Grade 3以上の有害事象は28例(85%)[白血球・好中球減少21例(64%)、末梢神経障害3例(9%)など]に認められた。抗腫瘍効果は奏効率14.8%、病勢コントロール率66.7%であり、全生存期間および無増悪生存期間中央値はそれぞれ9.3ヵ月、4.7ヵ月であった。切除不能進行・再発胃癌に対するPTX+RAM療法は一定の効果が期待できるが、実地臨床においては高齢かつPSの悪い症例に対して使用することも多く、慎重なマネージメントが必要である。(著者抄録)

  • 食道癌患者の食道切除後の手術成績に対するGeriatric Nutritional Risk Indexの影響(The impact of geriatric nutritional risk index on surgical outcomes after esophagectomy in patients with esophageal cancer) Reviewed

    Kubo Naoshi, Sakurai Katsunobu, Tamura Tatsuro, Toyokawa Takahiro, Tanaka Hiroaki, Muguruma Kazuya, Yashiro Masakazu, Ohira Masaichi

    シュプリンガー・ジャパン(株) Esophagus   16 ( 2 )   147 - 154   2019.04( ISSN:1612-9059

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    食道扁平上皮癌(ESCC)患者におけるGeriatric Nutritional Risk Index(GNRI)と短期・長期手術成績との関連を調査した。2000〜2012年に当施設で外科的切除後に組織学的にESCCを確認した患者240例(男性196例、女性44例、平均63.4歳)を後ろ向きに調査した。全例が2〜3領域リンパ節郭清と併用して根治的食道切除術を受けた。GNRIのカットオフ値を92として、GNRI<92の低GNRI群44例とGNRI≧92の高GNRI群196例に分けた。リンパ節転移率と病理学的病期は高GNRI群よりも低GNRI群の方が有意に高かった。肺合併症の割合は高GNRI群よりも低GNRI群の方が有意に高かったが、多変量解析ではGNRIは肺合併症発症に対する独立危険因子ではなかった。5年全生存率は高GNRI群よりも低GNRI群の方が有意に低かった。GNRIは全生存率に対する独立予後因子であったが、癌特異的生存率(CSS)は予後因子ではなかった。腫瘍病期の階層化による解析では、全生存率、CSSともに病期III ESCC患者で高GNRI群よりも低GNRI群の方が悪化した。病期III ESCCでは原発腫瘍サイズは高GNRI群よりも低GNRI群の方が大きい傾向にあり、術前嚥下障害の発生率は高GNRI群よりも低GNRI群の方が有意に高かった。

  • Establishment of a New Scirrhous Gastric Cancer Cell Line with FGFR2 Overexpression, OCUM-14 Reviewed

    Okuno Tomohisa, Yashiro Masakazu, Masuda Go, Togano Shingo, Kuroda Kenji, Miki Yuichiro, Hirakawa Kosei, Ohsawa Masahiko, Wanibuchi Hideki, Ohira Masaichi

    ANNALS OF SURGICAL ONCOLOGY   26 ( 4 )   1093 - 1102   2019.04( ISSN:1068-9265

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    DOI: 10.1245/s10434-018-07145-2

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  • The impact of geriatric nutritional risk index on surgical outcomes after esophagectomy in patients with esophageal cancer Reviewed

    Kubo Naoshi, Sakurai Katsunobu, Tamura Tatsuro, Toyokawa Takahiro, Tanaka Hiroaki, Muguruma Kazuya, Yashiro Masakazu, Ohira Masaichi

    ESOPHAGUS   16 ( 2 )   147 - 154   2019.04( ISSN:1612-9059

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    DOI: 10.1007/s10388-018-0644-6

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  • Establishment of a New Scirrhous Gastric Cancer Cell Line with FGFR2 Overexpression, OCUM-14. Reviewed

    Okuno T, Yashiro M, Masuda G, Togano S, Kuroda K, Miki Y, Hirakawa K, Ohsawa M, Wanibuchi H, Ohira M

    Annals of surgical oncology   26 ( 4 )   1093 - 1102   2019.04( ISSN:1068-9265

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    DOI: 10.1245/s10434-018-07145-2

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  • The impact of geriatric nutritional risk index on surgical outcomes after esophagectomy in patients with esophageal cancer. Reviewed

    Kubo N, Sakurai K, Tamura T, Toyokawa T, Tanaka H, Muguruma K, Yashiro M, Ohira M

    Esophagus : official journal of the Japan Esophageal Society   16 ( 2 )   147 - 154   2019.04( ISSN:1612-9059

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    DOI: 10.1007/s10388-018-0644-6

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  • 食道癌患者の食道切除後の手術成績に対するGeriatric Nutritional Risk Indexの影響(The impact of geriatric nutritional risk index on surgical outcomes after esophagectomy in patients with esophageal cancer) Reviewed

    Kubo Naoshi, Sakurai Katsunobu, Tamura Tatsuro, Toyokawa Takahiro, Tanaka Hiroaki, Muguruma Kazuya, Yashiro Masakazu, Ohira Masaichi

    Esophagus   16 ( 2 )   147 - 154   2019.04( ISSN:1612-9059

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    食道扁平上皮癌(ESCC)患者におけるGeriatric Nutritional Risk Index(GNRI)と短期・長期手術成績との関連を調査した。2000~2012年に当施設で外科的切除後に組織学的にESCCを確認した患者240例(男性196例、女性44例、平均63.4歳)を後ろ向きに調査した。全例が2~3領域リンパ節郭清と併用して根治的食道切除術を受けた。GNRIのカットオフ値を92として、GNRI<92の低GNRI群44例とGNRI≧92の高GNRI群196例に分けた。リンパ節転移率と病理学的病期は高GNRI群よりも低GNRI群の方が有意に高かった。肺合併症の割合は高GNRI群よりも低GNRI群の方が有意に高かったが、多変量解析ではGNRIは肺合併症発症に対する独立危険因子ではなかった。5年全生存率は高GNRI群よりも低GNRI群の方が有意に低かった。GNRIは全生存率に対する独立予後因子であったが、癌特異的生存率(CSS)は予後因子ではなかった。腫瘍病期の階層化による解析では、全生存率、CSSともに病期III ESCC患者で高GNRI群よりも低GNRI群の方が悪化した。病期III ESCCでは原発腫瘍サイズは高GNRI群よりも低GNRI群の方が大きい傾向にあり、術前嚥下障害の発生率は高GNRI群よりも低GNRI群の方が有意に高かった。

  • 胆道癌の癌局所免疫における癌関連線維芽細胞の働き Reviewed

    田中 涼太, 木村 健二郎, 天野 良亮, 山添 定明, 大平 豪, 田内 潤, 西村 貞徳, 田中 浩明, 八代 正和, 大平 雅一

    日本外科学会定期学術集会抄録集   119回   PS - 8   2019.04

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  • 胃癌間質におけるThrombospondin4発現の検討 Reviewed

    黒田 顕慈, 八代 正和, 櫛山 周平, 西村 貞徳, 栂野 真吾, 奥野 倫久, 三木 友一朗, 豊川 貴弘, 田中 浩明, 六車 一哉, 平川 弘聖, 大平 雅一

    日本外科学会定期学術集会抄録集   119回   SF - 6   2019.04

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  • 家族性胃癌の臨床病理学的検討 Reviewed

    西村 貞徳, 八代 正和, 櫛山 周平, 栂野 真吾, 黒田 顕慈, 奥野 倫久, 田村 達郎, 豊川 貴弘, 木村 健二郎, 天野 良亮, 田中 浩明, 六車 一哉, 平川 弘聖, 大平 雅一

    日本外科学会定期学術集会抄録集   119回   PS - 2   2019.04

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  • トラニラスト、シスプラチン併用療法によるスキルス胃癌への治療効果の検討 Reviewed

    櫛山 周平, 八代 正和, 村橋 邦康, 奥野 倫久, 黒田 顕慈, 田中 涼太, 栂野 真吾, 西村 貞徳, 豊川 貴弘, 田中 浩明, 六車 一哉, 平川 弘聖, 大平 雅一

    日本外科学会定期学術集会抄録集   119回   PS - 6   2019.04

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  • スキルス胃癌細胞由来EVsの腹膜中皮細胞への影響の違い Reviewed

    奥野 倫久, 八代 正和, 櫛山 周平, 西村 貞徳, 栂野 真吾, 黒田 顕慈, 田村 達郎, 豊川 貴弘, 田中 浩明, 六車 一哉, 平川 弘聖, 大平 雅一

    日本外科学会定期学術集会抄録集   119回   SF - 7   2019.04

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  • 飢餓ストレスにおける胃癌幹細胞のオートファジーの意義 Reviewed

    栂野 真吾, 八代 正和, 増田 剛, 黒田 顕慈, 奥野 倫久, 西村 貞徳, 櫛山 周平, 三木 友一朗, 平川 弘聖, 大平 雅一

    日本外科学会定期学術集会抄録集   119回   SF - 8   2019.04

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  • Macrophage-mediated transfer of cancer-derived components to stromal cells contributes to establishment of a pro-tumor microenvironment Reviewed

    Umakoshi Michinobu, Takahashi So, Itoh Go, Kuriyama Sei, Sasaki Yuto, Yanagihara Kazuyoshi, Yashiro Masakazu, Maeda Daichi, Goto Akiteru, Tanaka Masamitsu

    ONCOGENE   38 ( 12 )   2162 - 2176   2019.03( ISSN:0950-9232

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    DOI: 10.1038/s41388-018-0564-x

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  • Clinicopathological Significance of Autophagy-related Proteins and its Association With Genetic Alterations in Gliomas Reviewed

    Tamrakar Samantha, Yashiro Masakazu, Kawashima Toshiyuki, Uda Takehiro, Terakawa Yuzo, Kuwae Yuko, Ohsawa Masahiko, Ohata Kenji

    ANTICANCER RESEARCH   39 ( 3 )   1233 - 1242   2019.03( ISSN:0250-7005

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    DOI: 10.21873/anticanres.13233

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  • Macrophage-mediated transfer of cancer-derived components to stromal cells contributes to establishment of a pro-tumor microenvironment. Reviewed

    Umakoshi M, Takahashi S, Itoh G, Kuriyama S, Sasaki Y, Yanagihara K, Yashiro M, Maeda D, Goto A, Tanaka M

    Oncogene   38 ( 12 )   2162 - 2176   2019.03( ISSN:0950-9232

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    DOI: 10.1038/s41388-018-0564-x

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  • Clinicopathological Significance of Autophagy-related Proteins and its Association With Genetic Alterations in Gliomas. Reviewed

    Tamrakar S, Yashiro M, Kawashima T, Uda T, Terakawa Y, Kuwae Y, Ohsawa M, Ohata K

    Anticancer research   39 ( 3 )   1233 - 1242   2019.03( ISSN:0250-7005

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    DOI: 10.21873/anticanres.13233

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  • A Pretreatment-Free, Polymer-Based Platform Prepared by Molecular Imprinting and Post-Imprinting Modifications for Sensing Intact Exosomes Reviewed

    Mori Kisho, Hirase Mitsuhiro, Morishige Takahiro, Takano Eri, Sunayama Hirobumi, Kitayama Yukiya, Inubushi Sachiko, Sasaki Ryohei, Yashiro Masakazu, Takeuchi Toshifumi

    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION   58 ( 6 )   1612 - 1615   2019.02( ISSN:1433-7851

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    DOI: 10.1002/anie.201811142

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  • A Pretreatment-Free, Polymer-Based Platform Prepared by Molecular Imprinting and Post-Imprinting Modifications for Sensing Intact Exosomes. Reviewed

    Mori K, Hirase M, Morishige T, Takano E, Sunayama H, Kitayama Y, Inubushi S, Sasaki R, Yashiro M, Takeuchi T

    Angewandte Chemie (International ed. in English)   58 ( 6 )   1612 - 1615   2019.02( ISSN:1433-7851

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    DOI: 10.1002/anie.201811142

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  • Adverse Effects of Preoperative Sarcopenia on Postoperative Complications of Patients With Gastric Cancer Reviewed

    Tamura Tatsuro, Sakurai Katsunobu, Nambara Mikio, Miki Yuichiro, Toyokawa Takahiro, Kubo Naoshi, Tanaka Hiroaki, Muguruma Kazuya, Yashiro Masakazu, Ohira Masaichi

    ANTICANCER RESEARCH   39 ( 2 )   987 - 992   2019.02( ISSN:0250-7005

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    DOI: 10.21873/anticanres.13203

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  • Oligodendrocytes Up-regulate the Invasive Activity of Glioblastoma Cells via the Angiopoietin-2 Signaling Pathway Reviewed

    Kawashima Toshiyuki, Yashiro Masakazu, Kasashima Hiroaki, Terakawa Yuzo, Uda Takehiro, Nakajo Kosuke, Umaba Ryoko, Tanoue Yuta, Tamrakar Samantha, Ohata Kenji

    ANTICANCER RESEARCH   39 ( 2 )   577 - 584   2019.02( ISSN:0250-7005

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    DOI: 10.21873/anticanres.13150

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  • Adverse Effects of Preoperative Sarcopenia on Postoperative Complications of Patients With Gastric Cancer. Reviewed

    Tamura T, Sakurai K, Nambara M, Miki Y, Toyokawa T, Kubo N, Tanaka H, Muguruma K, Yashiro M, Ohira M

    Anticancer research   39 ( 2 )   987 - 992   2019.02( ISSN:0250-7005

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    DOI: 10.21873/anticanres.13203

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  • Oligodendrocytes Up-regulate the Invasive Activity of Glioblastoma Cells via the Angiopoietin-2 Signaling Pathway. Reviewed

    Kawashima T, Yashiro M, Kasashima H, Terakawa Y, Uda T, Nakajo K, Umaba R, Tanoue Y, Tamrakar S, Ohata K

    Anticancer research   39 ( 2 )   577 - 584   2019.02( ISSN:0250-7005

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    DOI: 10.21873/anticanres.13150

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  • スキルス胃癌細胞由来EVsは腹膜中皮細胞にmesenchymal transitionを引き起こす Reviewed

    奥野 倫久, 八代 正和, 櫛山 周平, 西村 貞徳, 栂野 真吾, 黒田 顕慈, 田村 達郎, 豊川 貴弘, 田中 浩明, 六車 一哉, 平川 弘聖, 大平 雅一

    日本胃癌学会総会記事   91回   490 - 490   2019.02

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  • 家族性胃癌の臨床病学的因子の検討 Reviewed

    西村 貞徳, 八代 正和, 櫛山 周平, 栂野 真吾, 黒田 顕慈, 奥野 倫久, 平川 弘聖, 大平 雅一

    日本胃癌学会総会記事   91回   538 - 538   2019.02

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  • 特集 スキルス胃癌のすべて I. 基礎 3.スキルス胃癌腹膜播種形成の分子機構と分子標的治療 Reviewed

    八代 正和, 大平 雅一

    外科   81 ( 1 )   12 - 15   2019.01( ISSN:0016593X ( eISSN:24329428

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    DOI: 10.15106/j_geka81_12

  • スキルス胃癌細胞株由来Exosomeは腹膜中皮細胞のmesothelial-mesenchymal transitionを引き起こし腹膜転移に関与する Reviewed

    奥野 倫久, 八代 正和, 櫛山 周平, 西村 貞徳, 栂野 真吾, 黒田 顕慈, 田村 達郎, 豊川 貴弘, 田中 浩明, 六車 一哉, 平川 弘聖, 大平 雅一

    日本分子腫瘍マーカー研究会 日本分子腫瘍マーカー研究会誌   34   23 - 25   2019.01

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    スキルス胃癌(SGC)細胞由来Exosomeの腹膜への分布とその影響を検討した。In vitroにおけるlive imagingと蛍光顕微鏡による検討の結果、SGC細胞由来Exosomeは腹膜中皮細胞に取り込まれやすく、腹膜中皮細胞を敷石状から紡錘形に形態変化させた。SGC由来のPKH26標識Exosomeをヌードマウスに3週間尾静脈投与を行った結果、腹膜に指向性に集積した。また胃癌切除組織症例における腹膜のExosomeマーカー(CD9、CD63)の発現は遠隔転移と有意に相関していたことから、CD9およびCD63は腹膜転移の予測因子であることが示唆された。

  • スキルス胃癌細胞株由来Exosomeは腹膜中皮細胞のmesothelial-mesenchymal transitionを引き起こし腹膜転移に関与する Reviewed

    奥野 倫久, 八代 正和, 櫛山 周平, 西村 貞徳, 栂野 真吾, 黒田 顕慈, 田村 達郎, 豊川 貴弘, 田中 浩明, 六車 一哉, 平川 弘聖, 大平 雅一

    日本分子腫瘍マーカー研究会誌   34   23 - 25   2019.01

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    スキルス胃癌(SGC)細胞由来Exosomeの腹膜への分布とその影響を検討した。In vitroにおけるlive imagingと蛍光顕微鏡による検討の結果、SGC細胞由来Exosomeは腹膜中皮細胞に取り込まれやすく、腹膜中皮細胞を敷石状から紡錘形に形態変化させた。SGC由来のPKH26標識Exosomeをヌードマウスに3週間尾静脈投与を行った結果、腹膜に指向性に集積した。また胃癌切除組織症例における腹膜のExosomeマーカー(CD9、CD63)の発現は遠隔転移と有意に相関していたことから、CD9およびCD63は腹膜転移の予測因子であることが示唆された。

  • スキルス胃癌細胞株由来Exosomeは腹膜中皮細胞のmesothelial-mesenchymal transitionを引き起こし腹膜転移に関与する Reviewed

    奥野 倫久, 八代 正和, 櫛山 周平, 西村 貞徳, 栂野 真吾, 黒田 顕慈, 田村 達郎, 豊川 貴弘, 田中 浩明, 六車 一哉, 平川 弘聖, 大平 雅一

    日本分子腫瘍マーカー研究会誌   34   23 - 25   2019.01( eISSN:2433-8575

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    スキルス胃癌(SGC)細胞由来Exosomeの腹膜への分布とその影響を検討した。In vitroにおけるlive imagingと蛍光顕微鏡による検討の結果、SGC細胞由来Exosomeは腹膜中皮細胞に取り込まれやすく、腹膜中皮細胞を敷石状から紡錘形に形態変化させた。SGC由来のPKH26標識Exosomeをヌードマウスに3週間尾静脈投与を行った結果、腹膜に指向性に集積した。また胃癌切除組織症例における腹膜のExosomeマーカー(CD9、CD63)の発現は遠隔転移と有意に相関していたことから、CD9およびCD63は腹膜転移の予測因子であることが示唆された。

    Other URL: https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2019&ichushi_jid=J04910&link_issn=&doc_id=20191118260011&doc_link_id=10.11241%2Fjsmtmr.34.23&url=https%3A%2F%2Fdoi.org%2F10.11241%2Fjsmtmr.34.23&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_3.gif

  • The clinicopathological significance of Thrombospondin-4 expression in the tumor microenvironment of gastric cancer. Reviewed

    Kuroda K, Yashiro M, Sera T, Yamamoto Y, Kushitani Y, Sugimoto A, Kushiyama S, Nishimura S, Togano S, Okuno T, Tamura T, Toyokawa T, Tanaka H, Muguruma K, Ohira M

    PloS one   14 ( 11 )   e0224727   2019

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    DOI: 10.1371/journal.pone.0224727

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  • Exosomes from scirrhous gastric cancer cells might affect on the morphology of peritoneal mesothelial cells and induce peritoneal metastasis Reviewed

    Okuno Tomohisa, Muguruma Kazuya, Hirakawa Kosei, Ohira Masaichi, Yashiro Masakazu, Kushiyama Shuhei, Nishimura Sadaaki, Togano Shingo, Kuroda Kenji, Tamura Tatsuro, Toyokawa Takahiro, Tanaka Hiroaki

    Japanese Society for Molecular Tumor Marker Research, Japan Journal of Molecular Tumor Marker Research   34 ( 0 )   23 - 25   2019

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    DOI: 10.11241/jsmtmr.34.23

    CiNii Article

  • The clinicopathological significance of Thrombospondin-4 expression in the tumor microenvironment of gastric cancer. Reviewed

    Kuroda K, Yashiro M, Sera T, Yamamoto Y, Kushitani Y, Sugimoto A, Kushiyama S, Nishimura S, Togano S, Okuno T, Tamura T, Toyokawa T, Tanaka H, Muguruma K, Ohira M

    PloS one   14 ( 11 )   e0224727   2019

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    DOI: 10.1371/journal.pone.0224727

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  • Exosomes from scirrhous gastric cancer cells might affect on the morphology of peritoneal mesothelial cells and induce peritoneal metastasis Reviewed

    Okuno Tomohisa, Yashiro Masakazu, Kushiyama Shuhei, Nishimura Sadaaki, Togano Shingo, Kuroda Kenji, Tamura Tatsuro, Toyokawa Takahiro, Tanaka Hiroaki, Muguruma Kazuya, Hirakawa Kosei, Ohira Masaichi

    Japan Journal of Molecular Tumor Marker Research   34 ( 0 )   23 - 25   2019( eISSN:24338575

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    DOI: 10.11241/jsmtmr.34.23

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  • [A Case of Appendiceal Cancer Wherein the Abdominal Abscess Ruptured into the Urinary Bladder Owing to Obstructive Appendicitis]. Reviewed

    Tsujio G, Nagahara H, Shibutani M, Fukuoka T, Matsutani S, Kusunoki C, Yamazoe S, Kimura K, Toyokawa T, Amano R, Tanaka H, Muguruma K, Yashiro M, Hirakawa K, Ohira M

    Gan to kagaku ryoho. Cancer & chemotherapy   45 ( 13 )   2458 - 2460   2018.12( ISSN:0385-0684

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  • Clinical significance of diffuse-type histologic type coexistence in gastric cancer Reviewed

    Tanaka Hiroaki, Muguruma Kazuya, Tamura Tatsuro, Toyokawa Takahiro, Shibutani Masatsune, Nagahara Hisashi, Yashiro Masakazu, Hirakawa Kosei, Ohira Masaichi

    CANCER SCIENCE   109   479 - 479   2018.12( ISSN:1349-7006

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  • The significance of autophagy of gastric cancer stem cells Reviewed

    Togano Shingo, Yashiro Masakazu, Masuda Go, Kuroda Kenji, Okuno Tomohisa, Miki Yuichiro, Tamura Tatsuro, Toyokawa Takahiro, Amano Ryosuke, Tanaka Hiroaki, Muguruma Kazuya, Ohira Masaichi, Hirakawa Kosei

    CANCER SCIENCE   109   1253 - 1253   2018.12( ISSN:1349-7006

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  • Functional Heterogeneity in Activated Fibroblasts Created by Extracellular Vesicles Reviewed

    Naito Yutaka, Yamamoto Yusuke, Yashiro Masakazu, Kiyono Tohru, Hirakawa Kosei, Yanagihara Kazuyoshi, Yasui Wataru, Ochiya Takahiro

    CANCER SCIENCE   109   266 - 266   2018.12( ISSN:1349-7006

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  • Extracellular vesicles from gastric carcinoma induce mesothelial-mesenchymal transition of peritoneal mesothelial cells Reviewed

    Okuno Tomohisa, Yashiro Masakazu, Togano Shingo, Kuroda Kenji, Miki Yuichiro, Kasashima Hiroaki, Tamura Tatsuro, Toyokawa Takahiro, Tanaka Hiroaki, Muguruma Kazuya, Hirakawa Kosei, Ohira Masaichi

    CANCER SCIENCE   109   475 - 475   2018.12( ISSN:1349-7006

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  • Macrophages transmit tumor-derived extracellular vesicles to stromal cells and create pro-tumor microenvironment Reviewed

    Tanaka Masamitsu, Umakoshi Michinobu, Takahashi So, Itoh Go, Kuriyama Sei, Yashiro Masakazu, Goto Akiteru

    CANCER SCIENCE   109   281 - 281   2018.12( ISSN:1349-7006

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  • 閉塞性虫垂炎による腹腔内膿瘍膀胱穿通を来した虫垂癌の1例 Reviewed

    辻尾 元, 永原 央, 渋谷 雅常, 福岡 達成, 松谷 慎治, 楠 誓子, 山添 定明, 木村 健二郎, 豊川 貴弘, 天野 良亮, 田中 浩明, 六車 一哉, 八代 正和, 平川 弘聖, 大平 雅一

    (株)癌と化学療法社 癌と化学療法   45 ( 13 )   2458 - 2460   2018.12( ISSN:0385-0684

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    症例は73歳、女性。下腹部痛、腹部膨満感を主訴に近医を受診、下腹部に腫瘍性病変を認め当院紹介となった。造影CT検査で、膀胱右前壁に壁肥厚および虫垂先端に連続する約6cm大の内部に壊死性変化を疑う腫瘤を認めた。虫垂腫瘍膀胱浸潤や膀胱腫瘍虫垂浸潤が疑われ手術の方針とした。約1ヵ月後の入院時に施行した造影CT検査にて虫垂先端の腫瘤は著明に縮小していたが膀胱の壁肥厚は残存しており、虫垂に造影効果を受ける腫瘤を認め、虫垂癌もしくは膀胱癌と考え手術を施行した。術中所見では虫垂先端が膀胱壁と一塊になっており、膀胱壁を含めた虫垂切除を行い、虫垂中部に約1cm大の腫瘍を認めた。迅速病理検査にて虫垂癌と診断されたため、回盲部切除+D2リンパ節郭清を追加した。病理組織学的検査で虫垂癌、pT2N0M0、pStage Iの診断、虫垂癌による閉塞性虫垂炎で虫垂が穿破し、腹腔内膿瘍を形成、膀胱に穿通したものと考えた。(著者抄録)

  • [A Case of Appendiceal Cancer Wherein the Abdominal Abscess Ruptured into the Urinary Bladder Owing to Obstructive Appendicitis]. Reviewed

    Tsujio G, Nagahara H, Shibutani M, Fukuoka T, Matsutani S, Kusunoki C, Yamazoe S, Kimura K, Toyokawa T, Amano R, Tanaka H, Muguruma K, Yashiro M, Hirakawa K, Ohira M

    Gan to kagaku ryoho. Cancer & chemotherapy   45 ( 13 )   2458 - 2460   2018.12( ISSN:0385-0684

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    PubMed

  • 閉塞性虫垂炎による腹腔内膿瘍膀胱穿通を来した虫垂癌の1例 Reviewed

    辻尾 元, 永原 央, 渋谷 雅常, 福岡 達成, 松谷 慎治, 楠 誓子, 山添 定明, 木村 健二郎, 豊川 貴弘, 天野 良亮, 田中 浩明, 六車 一哉, 八代 正和, 平川 弘聖, 大平 雅一

    癌と化学療法   45 ( 13 )   2458 - 2460   2018.12( ISSN:0385-0684

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    症例は73歳、女性。下腹部痛、腹部膨満感を主訴に近医を受診、下腹部に腫瘍性病変を認め当院紹介となった。造影CT検査で、膀胱右前壁に壁肥厚および虫垂先端に連続する約6cm大の内部に壊死性変化を疑う腫瘤を認めた。虫垂腫瘍膀胱浸潤や膀胱腫瘍虫垂浸潤が疑われ手術の方針とした。約1ヵ月後の入院時に施行した造影CT検査にて虫垂先端の腫瘤は著明に縮小していたが膀胱の壁肥厚は残存しており、虫垂に造影効果を受ける腫瘤を認め、虫垂癌もしくは膀胱癌と考え手術を施行した。術中所見では虫垂先端が膀胱壁と一塊になっており、膀胱壁を含めた虫垂切除を行い、虫垂中部に約1cm大の腫瘍を認めた。迅速病理検査にて虫垂癌と診断されたため、回盲部切除+D2リンパ節郭清を追加した。病理組織学的検査で虫垂癌、pT2N0M0、pStage Iの診断、虫垂癌による閉塞性虫垂炎で虫垂が穿破し、腹腔内膿瘍を形成、膀胱に穿通したものと考えた。(著者抄録)

  • High stromaltransforming growth factor -induced expression is a novel marker of progression and poor prognosis in gastric cancer Reviewed

    Suzuki Masaki, Yokobori Takehiko, Gombodorj Navchaa, Yashiro Masakazu, Turtoi Andrei, Handa Tadashi, Ogata Kyoichi, Oyama Tetsunari, Shirabe Ken, Kuwano Hiroyuki

    JOURNAL OF SURGICAL ONCOLOGY   118 ( 6 )   966 - 974   2018.11( ISSN:0022-4790

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    DOI: 10.1002/jso.25217

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  • High stromal transforming growth factor β-induced expression is a novel marker of progression and poor prognosis in gastric cancer. Reviewed

    Suzuki M, Yokobori T, Gombodorj N, Yashiro M, Turtoi A, Handa T, Ogata K, Oyama T, Shirabe K, Kuwano H

    Journal of surgical oncology   118 ( 6 )   966 - 974   2018.11( ISSN:0022-4790

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    DOI: 10.1002/jso.25217

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  • The significance of scirrhous gastric cancer cell lines: the molecular characterization using cell lines and mouse models Reviewed

    Yashiro Masakazu, Matsuoka Tasuku, Ohira Masaichi

    HUMAN CELL   31 ( 4 )   271 - 281   2018.10( ISSN:1749-0774

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    DOI: 10.1007/s13577-018-0211-4

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  • The significance of scirrhous gastric cancer cell lines: the molecular characterization using cell lines and mouse models Reviewed

    Masakazu Yashiro, Tasuku Matsuoka, Masaichi Ohira

    Human Cell   31 ( 4 )   271 - 281   2018.10( ISSN:0914-7470

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    Scirrhous gastric cancer (SGC) exhibits aggressiveness of the rapid infiltrating tumor cells with abundant fibroblasts. Experimental studies using SGC cell lines have obtained useful information about this cancer. Our literature search divulged a total of 18 SGC cell lines
    two cell lines were established from primary SGC and the other lines were established from a metastatic lesion of SGC. Fibroblast growth factor receptor 2 (FGFR2) and transforming growth factor-beta receptor (TβR) are linked to the rapid development of SGC. Cross-talk between the cancer cells and cancer-associated fibroblasts (CAFs) has been shown to contribute to the progression of SGC. Chemokine (C-X-C motif) receptor 1 (CXCR1) from SGC cells might be associated with the abundant CAFs in cancer microenvironments. The in vivo models established using SGC cell lines are expected to serve as a useful tool for the development of drugs such as FGFR2 inhibitors, TβR inhibitors, and CXCR1 inhibitors, which might be promising as SGC treatments. However, the number of available SGC cell lines is insufficient for the clarification of the entire biologic behavior of SGC. Since the mechanisms responsible for the characteristic aggressiveness of SGC are not fully elucidated, the establishment of new SGC cell lines could help clarify the biological behavior of SGC and contribute to its treatment.

    DOI: 10.1007/s13577-018-0211-4

    PubMed

  • 膵頭十二指腸切除術後における膵液瘻発症の危険因子の検討 Reviewed

    田内 潤, 木村 健二郎, 天野 良亮, 山添 定明, 大平 豪, 田中 涼太, 西村 貞徳, 田村 達郎, 渋谷 雅常, 永原 央, 豊川 貴弘, 田中 浩明, 六車 一哉, 八代 正和, 大平 雅一

    日本臨床外科学会雑誌   79 ( 増刊 )   801 - 801   2018.10( ISSN:1345-2843 ( eISSN:1882-5133

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  • 同時性遠隔転移あるいは術後再発を生じた浸潤性膵癌における外科的介入の意義 Reviewed

    木村 健二郎, 天野 良亮, 山添 定明, 大平 豪, 田中 涼太, 田内 潤, 西村 貞徳, 柏原 伸一郎, 渋谷 雅常, 田中 浩明, 六車 一哉, 八代 正和, 平川 弘聖, 大平 雅一

    日本癌治療学会学術集会抄録集   56回   P92 - 5   2018.10

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  • 膵癌に対するGemcitabine+nab-paclitaxel療法の当院での治療成績 Reviewed

    田中 涼太, 木村 健二郎, 天野 良亮, 山添 定明, 大平 豪, 田内 潤, 西村 貞徳, 永原 央, 豊川 貴弘, 田中 浩明, 六車 一哉, 八代 正和, 平川 弘聖, 大平 雅一

    日本癌治療学会学術集会抄録集   56回   O18 - 4   2018.10

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  • Clinico-pathological significance of exosome marker CD63 expression on cancer cells and stromal cells in gastric cancer Reviewed

    Miki Yuichiro, Yashiro Masakazu, Okuno Tomohisa, Kuroda Kenji, Togano Shingo, Hirakawa Kosei, Ohira Masaichi

    PLOS ONE   13 ( 9 )   e0202956   2018.09( ISSN:1932-6203

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    DOI: 10.1371/journal.pone.0202956

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  • スキルス胃癌由来細胞外小胞顆粒によるCAFの機能的不均一性(Functional Heterogeneity in Activated Fibroblasts Created by Extracellular Vesicles) Reviewed

    内藤 寛, 山本 雄介, 八代 正和, 清野 透, 平川 弘聖, 柳原 五吉, 安井 弥, 落谷 孝広

    日本癌学会総会記事   77回   349 - 349   2018.09( ISSN:0546-0476

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  • スキルス胃癌細胞株由来Exosomeは腹膜中皮細胞のmesothelial-mesenchymal transitionを引き起こし腹膜転移に関与する Reviewed

    奥野 倫久, 八代 正和, 櫛山 周平, 西村 貞徳, 栂野 真吾, 黒田 顕慈, 田村 達郎, 豊川 貴弘, 田中 浩明, 六車 一哉, 平川 弘聖, 大平 雅一

    日本分子腫瘍マーカー研究会プログラム・講演抄録   38回   40 - 42   2018.09

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  • C-X-C Motif Ligand 1 (CXCL1) from melanoma cells down-regulates the invasion of their metastatic melanoma cells. Reviewed

    Hatano T, Yashiro M, Fujikawa H, Motomura H

    Oncotarget   9 ( 57 )   31090 - 31097   2018.07

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    DOI: 10.18632/oncotarget.25783

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  • C-X-C Motif Ligand 1 (CXCL1) from melanoma cells down-regulates the invasion of their metastatic melanoma cells. Reviewed

    Hatano T, Yashiro M, Fujikawa H, Motomura H

    Oncotarget   9 ( 57 )   31090 - 31097   2018.07

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    DOI: 10.18632/oncotarget.25783

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  • Biomarkers of gastric cancer: Current topics and future perspective Reviewed

    Matsuoka Tasuku, Yashiro Masakazu

    WORLD JOURNAL OF GASTROENTEROLOGY   24 ( 26 )   2818 - 2832   2018.07( ISSN:1007-9327

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    DOI: 10.3748/wjg.v24.i26.2818

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  • Biomarkers of gastric cancer: Current topics and future perspective. Reviewed

    Matsuoka T, Yashiro M

    World journal of gastroenterology   24 ( 26 )   2818 - 2832   2018.07( ISSN:1007-9327

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    DOI: 10.3748/wjg.v24.i26.2818

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  • C-X-C motif ligand 1 from melanoma cells downregulates the invasion of their metastatic melanoma cells Reviewed

    Hatano Takaharu, Yashiro Masakazu, Motomura Hisashi, Fujikawa Heishiro, Maeda Shusaku

    CANCER RESEARCH   78 ( 13 )   2018.07( ISSN:0008-5472

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    DOI: 10.1158/1538-7445.AM2018-4507

  • Effect of cancer-associated fibroblasts on the progression of malignant melanoma cells Reviewed

    Fujikawa Heishiro, Yashiro Masakazu, Hatano Takaharu, Maeda Shusaku, Motomura Hisashi

    CANCER RESEARCH   78 ( 13 )   2018.07( ISSN:0008-5472

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    DOI: 10.1158/1538-7445.AM2018-4489

  • Pyruvate kinase isozymes M2 and glutaminase might be promising molecular targets for the treatment of gastric cancer Reviewed

    Yashiro Masakazu, Kitayama Kishu

    CANCER RESEARCH   78 ( 13 )   2018.07( ISSN:0008-5472

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    DOI: 10.1158/1538-7445.AM2018-5484

  • Loss of E-cadherin expression is a critical step for peritoneal metastasis of gastric cancer with sub-serosal invasion Reviewed

    Togano Shingo, Yashiro Masakazu, Kuroda Kenji, Okuno Tomohisa, Miki Yuichiro, Hirakawa Kosei, Ohira Masaichi

    CANCER RESEARCH   78 ( 13 )   2018.07( ISSN:0008-5472

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    DOI: 10.1158/1538-7445.AM2018-4030

  • Effect of extracellular vesicles from gastric cancer cells on the morphologic and genetic changes of peritoneal mesothelial cells Reviewed

    Okuno Tomohisa, Yashiro Masakazu, Togano Shingo, Kuroda Kenji, Miki Yuichiro, Kasashima Hiroaki, Hirakawa Kosei, Ohira Masaichi

    CANCER RESEARCH   78 ( 13 )   2018.07( ISSN:0008-5472

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    DOI: 10.1158/1538-7445.AM2018-5219

  • Comparison of the prognostic impact and combination of preoperative inflammation-based and/or nutritional markers in patients with stage II gastric cancer. Reviewed

    Toyokawa T, Muguruma K, Tamura T, Sakurai K, Amano R, Kubo N, Tanaka H, Yashiro M, Hirakawa K, Ohira M

    Oncotarget   9 ( 50 )   29351 - 29364   2018.06

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    DOI: 10.18632/oncotarget.25486

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  • Comparison of the prognostic impact and combination of preoperative inflammation-based and/or nutritional markers in patients with stage II gastric cancer. Reviewed

    Toyokawa T, Muguruma K, Tamura T, Sakurai K, Amano R, Kubo N, Tanaka H, Yashiro M, Hirakawa K, Ohira M

    Oncotarget   9 ( 50 )   29351 - 29364   2018.06

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    DOI: 10.18632/oncotarget.25486

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  • Neutrophils in primary gastric tumors are correlated with neutrophil infiltration in tumor-draining lymph nodes and the systemic inflammatory response Reviewed

    Hiramatsu Soichiro, Tanaka Hiroaki, Nishimura Junya, Sakimura Chie, Tamura Tatsuro, Toyokawa Takahiro, Muguruma Kazuya, Yashiro Masakazu, Hirakawa Kosei, Ohira Masaichi

    BMC IMMUNOLOGY   19 ( 1 )   13   2018.04

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    DOI: 10.1186/s12865-018-0251-2

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  • Neutrophils in primary gastric tumors are correlated with neutrophil infiltration in tumor-draining lymph nodes and the systemic inflammatory response Reviewed

    Soichiro Hiramatsu, Hiroaki Tanaka, Junya Nishimura, Chie Sakimura, Tatsuro Tamura, Takahiro Toyokawa, Kazuya Muguruma, Masakazu Yashiro, Kosei Hirakawa, Masaichi Ohira

    BMC Immunology   19 ( 1 )   13   2018.04( ISSN:1471-2172

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    Background: Tumor-Associated Neutrophils (TANs) may be able to induce lymphangiogenesis and angiogenesis, although the detailed roles of TANs remain unclear. The Neutrophil-Lymphocyte Ratio (NLR) is an inflammation-based prognostic factor for gastric cancer. This study aimed to investigate the distribution of CD15+neutrophils in the primary tumor and Tumor-Draining Lymph Nodes (TDLNs), and to examine the association of TANs with the clinicopathological features (including NLR) of patients with gastric cancer. Results: Immunohistochemical staining showed that the median number of CD15+TANs was 18 and 24 per high-power field (HPF) in primary tumors and TDLNs, respectively. Patients were divided into high and low infiltration groups based on the median number. A high number of infiltrating CD15+TANs in the primary tumors and in the TDLNs were associated with depth of invasion and lymph node metastasis. Kaplan-Meier analysis revealed that a poor overall survival was associated with high numbers of CD15+TANs, and the multivariate analyses revealed that a high number of CD15+TANs in the TDLNs was an independent prognostic factor. The numbers of CD15+TANs in the primary tumors and TDLNs showed weak positive correlation. The number of CD15+TANs in the primary tumors was positively correlated with the preoperative NLR, (P=0.001, R=0.327) and immunohistochemical staining revealed that C-X-C motif chemokine receptor 2 (CXCR2) +neutrophils might be the origin of the CD15+TANs. Flow cytometry analysis indicated that infiltrating neutrophils increased in the tumor and TDLN compared to non-cancerous tissue. Neutrophils treated with cancer supernatant upregulated TWIST and IL-6 genes in vitro. Conclusion: Our findings suggested that local infiltration of CD15+TANs may be correlated with inflammation in TDLNs and systemic response to cause metastasis in gastric carcinoma.

    DOI: 10.1186/s12865-018-0251-2

    PubMed

  • 腫瘍炎症環境において間質に依存する胃癌進展の分子メカニズム Reviewed

    石本 崇胤, 三宅 慧輔, 八代 正和, 内原 智幸, 有馬 浩太, 泉 大輔, 岩槻 政晃, 馬場 祥史, 渡邊 雅之, Tan Patrick, 馬場 秀夫

    日本外科学会定期学術集会抄録集   118回   961 - 961   2018.04

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  • CD9-positive exosomes from cancer-associated fibroblasts stimulate the migration ability of scirrhous-type gastric cancer cells Reviewed

    Miki Yuichiro, Yashiro Masakazu, Okuno Tomohisa, Kitayama Kishu, Masuda Go, Hirakawa Kosei, Ohira Masaichi

    BRITISH JOURNAL OF CANCER   118 ( 6 )   867 - 877   2018.03( ISSN:0007-0920

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    DOI: 10.1038/bjc.2017.487

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  • CD9-positive exosomes from cancerassociated fibroblasts stimulate the migration ability of scirrhous-type gastric cancer cells Reviewed

    Yuichiro Miki, Masakazu Yashiro, Tomohisa Okuno, Kishu Kitayama, Go Masuda, Kosei Hirakawa, Masaichi Ohira

    British Journal of Cancer   118 ( 6 )   867 - 877   2018.03( ISSN:0007-0920

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    Background: Crosstalk between cancer cells and fibroblasts is crucial for tumour progression. It has been reported that exosomes derived from cancer cells play an important role in the intracellular communications involved in the development of carcinoma. However, the role of exosomes from fibroblasts remains unclear. This study aimed to clarify the effect of exosomes from fibroblasts on the motility of gastric cancer cells. Methods: 5 gastric cancer cell lines were used: OCUM-12, NUGC-3, MKN45, FU97 and MKN74. 2 cancer-associated fibroblasts (CAFs) were used. CD9 expression of exosomes from fibroblasts was examined by western blot. The effect of exosomes on the motility of cancer cells was analysed by migration assays. MMP2 was examined by RT-PCR or gelatin zymography. Then, CD9 and MMP2 expressions of 619 gastric cancers were analysed by immunohistochemistry. Results: Exosomes from CAFs were taken into scirrhous-type gastric cancer cells, namely OCUM-12 cells and NUGC-3 cells, but not into other types of gastric cancer cells. Exosomes from CAFs were positive for CD9. Exosomes from CAFs significantly stimulated the migration and invasion of OCUM-12 and NUGC-3 cells, which was inhibited by anti-CD9 antibody or CD9-siRNA. MMP2 expression of OCUM-12 and NUGC-3 cells was significantly decreased by CD9-siRNA. 116 CD9-positive cases were significantly correlated with scirrhous-type gastric cancer, lymph node metastasis and venous invasion. The 5-year survival rate of patients with CD9-positive tumours was significantly lower (Po0.001) than in those with CD9-negative tumours. Conclusions: CD9-positive exosomes from CAFs might stimulate the migration ability of scirrhous-type gastric cancer cells.

    DOI: 10.1038/bjc.2017.487

    PubMed

  • 胃癌の微小環境からみた腫瘍免疫の基礎 Reviewed

    田中 浩明, 田村 達郎, 吉井 真美, 大北 仁裕, 徳本 真央, 呉 幸枝, 崎村 千恵, 平松 宗一郎, 西村 潤也, 山越 義仁, 三木 友一朗, 豊川 貴弘, 六車 一哉, 八代 正和, 平川 弘聖, 大平 雅一

    日本胃癌学会総会記事   90回   205 - 205   2018.03

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  • Significance of immune-cell infiltration in gastric Reviewed

    Hiroaki Tanaka, Tatsuro Tamura, Yoshihiro Okita, Mami Yoshii, Mao Tokumoto, Yukie Go, Chie Sakimura, Soichiro Hiramatsu, Junya Nishimura, Yoshihito Yamagoe, Masakazu Yashiro, Yuichiro Miki, Takahiro Toyokawa, Kazuya Muguruma, Kosei Hirakawa, Masaichi Ohira

    Japanese Journal of Cancer and Chemotherapy   45 ( 2 )   217 - 221   2018.02( ISSN:0385-0684

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    There are many reports on the association between infiltrating immune cells and cancer prognosis. It is generally thought that cancer cells escape from the immune surveillance system in vivo. Cells associated with tumor immunosuppressive mechanisms include macrophages, regulatory T cells, bone marrow-derived immunosuppressive cells (MDSC), and neutrophils. These immunosuppressive cells enhance the production of TGF-β and IL-10 and the expression of PDL-1 by cytokines produced by stromal cells such as cancer cells and fibroblasts, thereby inducing cytotoxic T cells lymphocytes (CTL). On the other hand, it has been proved that CD8+ T cells react in an antigen-specific manner even in advanced gastric cancer, suggesting the possibility that memory T cells, NK cells and NKT cells in gastric cancer tissues correlate with good prognosis. Recently, it has been reported that the presence of follicular lymphoid structure called tertiary lymphoid structure (TLS) in gastric cancer tissue is associated with favorable prognosis. Although immune responses are suppressed in gastric cancer tissues, the effectiveness of an immune checkpoint inhibitor (anti-PD-1 antibody) has been proved in 2017. The tumor-infiltrating immune cells is known as a predictive effect biomarker. As cancer genome research progresses, which type of immune response is induced is gradually being elucidated in near future. Thus, assessing the invasive morphology and function of various tumorinfiltrating immune cells is considered to be extremely important in Precision Medicine for gastric cancer.

    PubMed

  • [Significance of Immune-Cell Infiltration in Gastric]. Reviewed

    Tanaka H, Tamura T, Okita Y, Yoshii M, Tokumoto M, Go Y, Sakimura C, Hiramatsu S, Nishimura J, Yamagoe Y, Yashiro M, Miki Y, Toyokawa T, Muguruma K, Hirakawa K, Ohira M

    Gan to kagaku ryoho. Cancer & chemotherapy   45 ( 2 )   217 - 221   2018.02( ISSN:0385-0684

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  • [Significance of Immune-Cell Infiltration in Gastric]. Reviewed

    Tanaka H, Tamura T, Okita Y, Yoshii M, Tokumoto M, Go Y, Sakimura C, Hiramatsu S, Nishimura J, Yamagoe Y, Yashiro M, Miki Y, Toyokawa T, Muguruma K, Hirakawa K, Ohira M

    Gan to kagaku ryoho. Cancer & chemotherapy   45 ( 2 )   217 - 221   2018.02( ISSN:0385-0684

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  • CD9-positive Exosomes from CaF Stimulate the Migration Ability of Scirrhous-type Gastric Cancer Cells Reviewed

    Miki Yuichiro, Yashiro Masakazu, Okuno Tomohisa, Tamura Tatsuro, Toyokawa Takahiro, Tanaka Hiroaki, Muguruma Kazuya, Hirakawa Kesei, Ohira Masaichi

    CANCER SCIENCE   109   875 - 875   2018.01( ISSN:1349-7006

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  • Extracellular vesicle-driven crosstalk between cancer and stromal cells orchestrates the microenvironment for metastasis Reviewed

    Naito Yutaka, Yamamoto Yusuke, Yoshioka Yusuke, Yashiro Masakazu, Kiyono Tohru, Hirakawa Kosei, Yanagihara Kazuyoshi, Yasui Wataru, Ochiya Takahiro

    CANCER SCIENCE   109   486 - 486   2018.01( ISSN:1349-7006

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  • Establishment of a new scirrhous gastric cancer cell line with FGFR2 overexpression, OCUM-14. Reviewed

    Okuno Tomohisa, Yashiro Masakazu, Masuda Go, Kitayama Kishu, Hirakawa Kosei, Ohira Masaichi

    CANCER SCIENCE   109   644 - 644   2018.01( ISSN:1349-7006

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  • Protection of SDF-2 by Hsp72 prevents oxaliplatin-induced cell death in oxaliplatin-resistant human gastric cancer cells Reviewed

    Shiota Masayuki, Takahashi Katsuyuki, Yashiro Masakazu, Tanaka Masako

    CANCER SCIENCE   109   64 - 64   2018.01( ISSN:1349-7006

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  • Possibility of inducing tumor infiltrating lymphocytes by B cells in tertiary lymphoid structures in gastric cancer Reviewed

    Tanaka Hiroaki, Sakimura Chie, Kazuya Muguruma, Tamura Tatsuro, Shibutani Masatsune, Kimura Kenjiro, Nagahara Hisashi, Toyokawa Takahiro, Amano Ryosuke, Yashiro Masakazu, Hirakawa Kosei, Ohira Masaichi

    CANCER SCIENCE   109   837 - 837   2018.01( ISSN:1349-7006

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  • 【Borderline resectable膵癌に対する集学的治療】技術的切除可能な主要動脈浸潤局所進行膵癌に対するR0を目指した集学的治療 Reviewed

    天野 良亮, 木村 健二郎, 山添 定明, 西尾 康平, 大平 豪, 渋谷 雅常, 永原 央, 豊川 貴弘, 田中 浩明, 六車 一哉, 八代 正和, 前田 清, 平川 弘聖, 大平 雅一

    (株)篠原出版新社 癌の臨床   63 ( 5 )   447 - 453   2018.01( ISSN:0021-4949

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    肝動脈浸潤・接触、上腸間膜動脈接触を認める局所進行膵癌42例中、膵切除を行った30例を対象とした。術前化学放射線療法の完遂率は97.6%、外科切除率は71.4%であった。NCCNガイドラインにおけるBorderline resectable(BR)が14例、Unresectable(UR)が16例で、術前治療により腫瘍径、腫瘍マーカーともに有意な低下を認めた。PD-CARやPD-CHAR、TP-CARなどの肝動脈合併膵切除症例が14例で、10例に肝動脈再建を要した。門脈合併切除は70%に行い、術中輸血率は60%であった。grade 3a以上の術後合併症発症率は36.7%であった。胃排出遅延は16.7%に認め、1例が在院死亡に至った。病理所見では、リンパ節転移例は33.3%、膵頭神経叢浸潤は43.3%、門脈浸潤率は30%であった。病理学的な90%以上の腫瘍壊死効果は43.3%に認め、R0切除率は93.3%であった。S-1による術後補助化学療法導入率は82.6%であった。2年生存率は56.1%であった。

  • 【Borderline resectable膵癌に対する集学的治療】技術的切除可能な主要動脈浸潤局所進行膵癌に対するR0を目指した集学的治療 Reviewed

    天野 良亮, 木村 健二郎, 山添 定明, 西尾 康平, 大平 豪, 渋谷 雅常, 永原 央, 豊川 貴弘, 田中 浩明, 六車 一哉, 八代 正和, 前田 清, 平川 弘聖, 大平 雅一

    癌の臨床   63 ( 5 )   447 - 453   2018.01( ISSN:0021-4949

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    肝動脈浸潤・接触、上腸間膜動脈接触を認める局所進行膵癌42例中、膵切除を行った30例を対象とした。術前化学放射線療法の完遂率は97.6%、外科切除率は71.4%であった。NCCNガイドラインにおけるBorderline resectable(BR)が14例、Unresectable(UR)が16例で、術前治療により腫瘍径、腫瘍マーカーともに有意な低下を認めた。PD-CARやPD-CHAR、TP-CARなどの肝動脈合併膵切除症例が14例で、10例に肝動脈再建を要した。門脈合併切除は70%に行い、術中輸血率は60%であった。grade 3a以上の術後合併症発症率は36.7%であった。胃排出遅延は16.7%に認め、1例が在院死亡に至った。病理所見では、リンパ節転移例は33.3%、膵頭神経叢浸潤は43.3%、門脈浸潤率は30%であった。病理学的な90%以上の腫瘍壊死効果は43.3%に認め、R0切除率は93.3%であった。S-1による術後補助化学療法導入率は82.6%であった。2年生存率は56.1%であった。

  • Significance of the Lysyl Oxidase Members Lysyl Oxidase Like 1, 3, and 4 in Gastric Cancer Reviewed

    Kasashima Hiroaki, Yashiro Masakazu, Okuno Tomohisa, Miki Yuichiro, Kitayama Kisyu, Masuda Go, Kinoshita Haruhito, Morisaki Tamami, Fukuoka Tatsunari, Hasegawa Tsuyoshi, Sakurai Katsunobu, Toyokawa Takahiro, Kubo Naoshi, Tanaka Hiroaki, Muguruma Kazuya, Hirakawa Kosei, Ohira Masaichi

    DIGESTION   98 ( 4 )   238 - 248   2018( ISSN:0012-2823

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    DOI: 10.1159/000489558

    PubMed

  • Clinico-pathological significance of exosome marker CD63 expression on cancer cells and stromal cells in gastric cancer. Reviewed

    Miki Y, Yashiro M, Okuno T, Kuroda K, Togano S, Hirakawa K, Ohira M

    PloS one   13 ( 9 )   e0202956   2018

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    DOI: 10.1371/journal.pone.0202956

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  • Significance of the Lysyl Oxidase Members Lysyl Oxidase Like 1, 3, and 4 in Gastric Cancer. Reviewed

    Kasashima H, Yashiro M, Okuno T, Miki Y, Kitayama K, Masuda G, Kinoshita H, Morisaki T, Fukuoka T, Hasegawa T, Sakurai K, Toyokawa T, Kubo N, Tanaka H, Muguruma K, Hirakawa K, Ohira M

    Digestion   98 ( 4 )   238 - 248   2018( ISSN:0012-2823

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    DOI: 10.1159/000489558

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  • Pyruvate kinase isozyme M2 and glutaminase might be promising molecular targets for the treatment of gastric cancer Reviewed

    Kitayama Kishu, Yashiro Masakazu, Morisaki Tamami, Miki Yuichiro, Okuno Tomohisa, Kinoshita Haruhito, Fukuoka Tatsunari, Kasashima Hiroaki, Masuda Go, Hasegawa Tsuyoshi, Sakurai Katsunobu, Kubo Naoshi, Hirakawa Kosei, Ohira Masaichi

    CANCER SCIENCE   108 ( 12 )   2462 - 2469   2017.12( ISSN:1349-7006

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    DOI: 10.1111/cas.13421

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  • Examination of cancer cells exposed to gastric serosa by serosal stamp cytology plus RT-PCR is useful for the identification of gastric cancer patients at high risk of peritoneal recurrence Reviewed

    Miki Yuichiro, Yashiro Masakazu, Ando Kanae, Okuno Tomohisa, Kitayama Kishu, Masuda Go, Tamura Tatsuro, Sakurai Katsunobu, Toyokawa Takahiro, Kubo Naoshi, Tanaka Hiroaki, Muguruma Kazuya, Osawa Masahiko, Hirakawa Kosei, Ohira Masaichi

    SURGICAL ONCOLOGY-OXFORD   26 ( 4 )   352 - 358   2017.12( ISSN:0960-7404

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    DOI: 10.1016/j.suronc.2017.07.008

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  • ピルビン酸キナーゼアイソザイムM2およびグルタミナーゼは胃癌の治療に対する有望な分子標的となる可能性がある(Pyruvate kinase isozyme M2 and glutaminase might be promising molecular targets for the treatment of gastric cancer) Reviewed

    Kitayama Kishu, Yashiro Masakazu, Morisaki Tamami, Miki Yuichiro, Okuno Tomohisa, Kinoshita Haruhito, Fukuoka Tatsunari, Kasashima Hiroaki, Masuda Go, Hasegawa Tsuyoshi, Sakurai Katsunobu, Kubo Naoshi, Hirakawa Kosei, Ohira Masaichi

    John Wiley & Sons Australia, Ltd Cancer Science   108 ( 12 )   2462 - 2469   2017.12( ISSN:1347-9032

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    低酸素環境下の胃癌細胞の増殖に対する反応における解糖系およびグルタミン代謝に対する酵素の重要性を評価した。4種の低酸素耐性胃癌細胞株と患者細胞株を用い、代謝に関連した酵素のmRNA発現解析および、これらの酵素が細胞増殖に及ぼす影響について調べた。全ての低酸素耐性胃癌細胞株において、解糖系酵素ピルビン酸キナーゼのアイソザイムM2(PKM2)およびグルタミナーゼ(GLS)mRNAは患者細胞と比較して高値を示した。siRNAによるノックダウンにより低酸素耐性胃癌細胞株の増殖は減少した。また、siRNAによるノックダウンまたはPKM2阻害剤シコニンとGLS阻害剤BPTES処置では、それぞれ単体よりも併用により有意に細胞増殖が減少した。in vivoにおいても併用処置により腫瘍サイズが減少した。以上より、PKM2とGLSは低酸素胃癌細胞の増殖に重要な役割を果たし、これら阻害剤の併用が胃癌治療に有用と考えられた。

  • Examination of cancer cells exposed to gastric serosa by serosal stamp cytology plus RT-PCR is useful for the identification of gastric cancer patients at high risk of peritoneal recurrence Reviewed

    Yuichiro Miki, Masakazu Yashiro, Kanae Ando, Tomohisa Okuno, Kishu Kitayama, Go Masuda, Tatsuro Tamura, Katsunobu Sakurai, Takahiro Toyokawa, Naoshi Kubo, Hiroaki Tanaka, Kazuya Muguruma, Masahiko Osawa, Kosei Hirakawa, Masaichi Ohira

    SURGICAL ONCOLOGY-OXFORD   26 ( 4 )   352 - 358   2017.12( ISSN:0960-7404 ( eISSN:1879-3320

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    Background: We sought to clarify the clinical value of the examination of cancer cells exposed to gastric serosa by our novel method of serosal stamp cytology and a real-time quantitative reverse transcription-polymerase chain reaction (RT-PCR) analysis.
    Method: A total of 70 patients who underwent gastrectomy were enrolled. Stamp cytology specimens were obtained by stamping the gastric serosa at the primary gastric tumor lesion, followed by Papanicolaou's staining. Samples obtained by brushing the serosa at the primary gastric tumor were analyzed by our RT-PCR of carcinoembryonic antigen (CEA) and cytokeratin 20 (CK20).
    Results: Among the 70 patients, 11 patients were diagnosed as stamp cytology-positive. Eight and five patients were found to be CEA-positive and CK20-positive, respectively. Since 21 of the 70 patients were either stamp cytology-positive or RT-PCR analysis-positive, these 21 patients were considered to be positive for cancer cells exposed to serosa of primary gastric tumor. The 3-year recurrence-free survival rate of the patients with a single positive result by our method (41.7%) was significantly (log rank p = 0.0002) worse than that of the patients with both negative results (81.0%). Our method showed 58.8% sensitivity and 79.2% specificity. A multivariate analysis revealed that a stamp cytology and/or RT-PCR result was an independent prognostic factor for recurrence.
    Conclusion: The examination of cancer cells exposed to gastric serosa by our serosal stamp cytology and RT-PCR system will be useful for the identification of patients at high risk for peritoneal recurrence after curative surgery for gastric cancer. (C) 2017 Elsevier Ltd. All rights reserved.

    DOI: 10.1016/j.suronc.2017.07.008

    PubMed

  • Pyruvate kinase isozyme M2 and glutaminase might be promising molecular targets for the treatment of gastric cancer Reviewed

    Kishu Kitayama, Masakazu Yashiro, Tamami Morisaki, Yuichiro Miki, Tomohisa Okuno, Haruhito Kinoshita, Tatsunari Fukuoka, Hiroaki Kasashima, Go Masuda, Tsuyoshi Hasegawa, Katsunobu Sakurai, Naoshi Kubo, Kosei Hirakawa, Masaichi Ohira

    Cancer Science   108 ( 12 )   2462 - 2469   2017.12( ISSN:1347-9032

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    The aim of this study was to analyze the significance of glucose metabolism-related enzymes in the proliferation of gastric cancer under hypoxia. Four hypoxia-resistant gastric cancer cell lines and four parent cell lines were used. Reverse transcription–PCR was used to evaluate the mRNA expression levels of the following metabolism-related enzymes: pyruvate kinase isozyme M2 (PKM2), glutaminase (GLS), enolase 1 (ENO1), glucose-6-phosphate dehydrogenase (G6PDH), and PKM1. The effects of these enzymes on the proliferation of gastric cancer cells were examined using siRNAs, shikonin as a PKM2 inhibitor, or BPTES as a GLS inhibitor, in vitro and in vivo. Levels of both PKM2 and GLS mRNA were significantly high in all hypoxia-resistant cell lines, compared with those of their parent cells. Knockdown of PKM2 and GLS significantly decreased the proliferation of all hypoxia-resistant cells. The combination of siPKM2 and siGLS significantly decreased proliferation compared with treatment by siPKM2 or siGLS alone. The knockdown of ENO1, G6PDH, or PKM1 did not decrease the proliferation of all hypoxia-resistant cells. Combination treatment using shikonin and BPTES inhibited the proliferation of all hypoxia-resistant cancer cells more than that by either agent alone. The in vivo study indicated that the tumor size treated by the combination of shikonin and BPTES was significantly smaller than that of vehicle-treated group. These findings suggested that PKM2 and GLS might play important roles in the proliferation of hypoxic gastric cancer cells. A combination of PKM2 and GLS inhibitors could be therapeutically promising for the treatment of gastric cancer.

    DOI: 10.1111/cas.13421

    PubMed

  • ピルビン酸キナーゼアイソザイムM2およびグルタミナーゼは胃癌の治療に対する有望な分子標的となる可能性がある(Pyruvate kinase isozyme M2 and glutaminase might be promising molecular targets for the treatment of gastric cancer) Reviewed

    Kitayama Kishu, Yashiro Masakazu, Morisaki Tamami, Miki Yuichiro, Okuno Tomohisa, Kinoshita Haruhito, Fukuoka Tatsunari, Kasashima Hiroaki, Masuda Go, Hasegawa Tsuyoshi, Sakurai Katsunobu, Kubo Naoshi, Hirakawa Kosei, Ohira Masaichi

    Cancer Science   108 ( 12 )   2462 - 2469   2017.12( ISSN:1347-9032

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    低酸素環境下の胃癌細胞の増殖に対する反応における解糖系およびグルタミン代謝に対する酵素の重要性を評価した。4種の低酸素耐性胃癌細胞株と患者細胞株を用い、代謝に関連した酵素のmRNA発現解析および、これらの酵素が細胞増殖に及ぼす影響について調べた。全ての低酸素耐性胃癌細胞株において、解糖系酵素ピルビン酸キナーゼのアイソザイムM2(PKM2)およびグルタミナーゼ(GLS)mRNAは患者細胞と比較して高値を示した。siRNAによるノックダウンにより低酸素耐性胃癌細胞株の増殖は減少した。また、siRNAによるノックダウンまたはPKM2阻害剤シコニンとGLS阻害剤BPTES処置では、それぞれ単体よりも併用により有意に細胞増殖が減少した。in vivoにおいても併用処置により腫瘍サイズが減少した。以上より、PKM2とGLSは低酸素胃癌細胞の増殖に重要な役割を果たし、これら阻害剤の併用が胃癌治療に有用と考えられた。

  • [A Case of Small Intestinal Metastasis with Intussusception Due to Barium]. Reviewed

    Tsujio G, Nagahara H, Nakao S, Fukuoka T, Shibutani M, Maeda K, Matsutani S, Kimura K, Toyokawa T, Amano R, Tanaka H, Muguruma K, Yashiro M, Hirakawa K, Ohira M

    Gan to kagaku ryoho. Cancer & chemotherapy   44 ( 12 )   1973 - 1975   2017.11( ISSN:0385-0684

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  • [A Case of Laparoscopic Surgery Performed for Locally Advanced Rectal Cancer Suspected of Invasion to Prostate]. Reviewed

    Nagahara H, Nakao S, Fukuoka T, Shibutani M, Maeda K, Matsutani S, Doi Y, Ohtani H, Yamazaki T, Amano R, Tanaka H, Muguruma K, Yashiro M, Hirakawa K, Ohira M

    Gan to kagaku ryoho. Cancer & chemotherapy   44 ( 12 )   1523 - 1525   2017.11( ISSN:0385-0684

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  • バリウム内服を契機に発症した小腸重積により診断された転移性小腸腫瘍の1例 Reviewed

    辻尾 元, 永原 央, 中尾 重富, 福岡 達成, 渋谷 雅常, 前田 清, 松谷 慎治, 木村 健二郎, 豊川 貴弘, 天野 良亮, 田中 浩明, 六車 一哉, 八代 正和, 平川 弘聖, 大平 雅一

    (株)癌と化学療法社 癌と化学療法   44 ( 12 )   1973 - 1975   2017.11( ISSN:0385-0684

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    症例は48歳、男性。受診2日前より嘔気を自覚、翌日に健康診断を受診し、胸部X線検査および食道・胃・十二指腸造影検査を施行した。胸部に異常陰影を指摘されたため当院に紹介受診となった。胸部〜骨盤部CT検査にて左肺門部に約4cm大の腫瘤を認め、小腸にtarget signを認めた。小腸重積の診断となり緊急手術の方針となった。開腹にて腹腔内を観察したところ、Treitz靱帯より約20cm、130cm肛門側の小腸に重積を認め、Hutchinson手技にて重積を解除し得た。口側の重積部では先進部に腫瘍を認めたが、肛門側の重積部では先進部に明らかな腫瘍性病変は認めずバリウム内服による蠕動亢進が原因と考えた。検索を進めたところ小腸に3ヶ所腫瘍性病変を認め、1ヶ所は口側腸重積の先進部となっていた。腫瘍を有する部位の小腸計3ヶ所を部分切除・再建し手術を終了した。病理組織検査では肺多型癌小腸転移の診断となり、現在外来で加療中である。(著者抄録)

  • 前立腺浸潤が疑われた局所進行直腸癌に対し腹腔鏡下に手術を施行した1例 Reviewed

    永原 央, 中尾 重富, 福岡 達成, 渋谷 雅常, 前田 清, 松谷 慎治, 土井 洋輔, 大谷 博, 山崎 健史, 天野 良亮, 田中 浩明, 六車 一哉, 八代 正和, 平川 弘聖, 大平 雅一

    (株)癌と化学療法社 癌と化学療法   44 ( 12 )   1523 - 1525   2017.11( ISSN:0385-0684

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    症例は58歳、男性。肛門痛、血便を主訴に他院を受診し、前立腺浸潤を伴う直腸癌と診断、人工肛門造設術を施行され、術前化学療法としてmFOLFOX6を6コース施行後、手術目的に当院を紹介受診となった。術前評価はPRであったが前立腺の浸潤は残存していると判断し、腹腔鏡下に腹会陰式直腸切断術、前立腺合併切除、尿道膀胱吻合による尿路再建を行い、術後第10病日に軽快退院となった。術後2年を経過した現在、明らかな排尿障害、残尿は認めず無再発生存中である。本術式は良好な術野が得られ、確実な切除が得られる点で非常に有用な術式であると思われた。(著者抄録)

  • [A Case of Small Intestinal Metastasis with Intussusception Due to Barium]. Reviewed

    Tsujio G, Nagahara H, Nakao S, Fukuoka T, Shibutani M, Maeda K, Matsutani S, Kimura K, Toyokawa T, Amano R, Tanaka H, Muguruma K, Yashiro M, Hirakawa K, Ohira M

    Gan to kagaku ryoho. Cancer & chemotherapy   44 ( 12 )   1973 - 1975   2017.11( ISSN:0385-0684

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  • [A Case of Small Intestinal Metastasis with Intussusception Due to Barium]. Reviewed

    Tsujio G, Nagahara H, Nakao S, Fukuoka T, Shibutani M, Maeda K, Matsutani S, Kimura K, Toyokawa T, Amano R, Tanaka H, Muguruma K, Yashiro M, Hirakawa K, Ohira M

    Gan to kagaku ryoho. Cancer & chemotherapy   44 ( 12 )   1973 - 1975   2017.11( ISSN:0385-0684

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  • [A Case of Laparoscopic Surgery Performed for Locally Advanced Rectal Cancer Suspected of Invasion to Prostate]. Reviewed

    Nagahara H, Nakao S, Fukuoka T, Shibutani M, Maeda K, Matsutani S, Doi Y, Ohtani H, Yamazaki T, Amano R, Tanaka H, Muguruma K, Yashiro M, Hirakawa K, Ohira M

    Gan to kagaku ryoho. Cancer & chemotherapy   44 ( 12 )   1523 - 1525   2017.11( ISSN:0385-0684

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  • [A Case of Laparoscopic Surgery Performed for Locally Advanced Rectal Cancer Suspected of Invasion to Prostate]. Reviewed

    Nagahara H, Nakao S, Fukuoka T, Shibutani M, Maeda K, Matsutani S, Doi Y, Ohtani H, Yamazaki T, Amano R, Tanaka H, Muguruma K, Yashiro M, Hirakawa K, Ohira M

    Gan to kagaku ryoho. Cancer & chemotherapy   44 ( 12 )   1523 - 1525   2017.11( ISSN:0385-0684

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  • バリウム内服を契機に発症した小腸重積により診断された転移性小腸腫瘍の1例 Reviewed

    辻尾 元, 永原 央, 中尾 重富, 福岡 達成, 渋谷 雅常, 前田 清, 松谷 慎治, 木村 健二郎, 豊川 貴弘, 天野 良亮, 田中 浩明, 六車 一哉, 八代 正和, 平川 弘聖, 大平 雅一

    癌と化学療法   44 ( 12 )   1973 - 1975   2017.11( ISSN:0385-0684

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    症例は48歳、男性。受診2日前より嘔気を自覚、翌日に健康診断を受診し、胸部X線検査および食道・胃・十二指腸造影検査を施行した。胸部に異常陰影を指摘されたため当院に紹介受診となった。胸部~骨盤部CT検査にて左肺門部に約4cm大の腫瘤を認め、小腸にtarget signを認めた。小腸重積の診断となり緊急手術の方針となった。開腹にて腹腔内を観察したところ、Treitz靱帯より約20cm、130cm肛門側の小腸に重積を認め、Hutchinson手技にて重積を解除し得た。口側の重積部では先進部に腫瘍を認めたが、肛門側の重積部では先進部に明らかな腫瘍性病変は認めずバリウム内服による蠕動亢進が原因と考えた。検索を進めたところ小腸に3ヶ所腫瘍性病変を認め、1ヶ所は口側腸重積の先進部となっていた。腫瘍を有する部位の小腸計3ヶ所を部分切除・再建し手術を終了した。病理組織検査では肺多型癌小腸転移の診断となり、現在外来で加療中である。(著者抄録)

  • 前立腺浸潤が疑われた局所進行直腸癌に対し腹腔鏡下に手術を施行した1例 Reviewed

    永原 央, 中尾 重富, 福岡 達成, 渋谷 雅常, 前田 清, 松谷 慎治, 土井 洋輔, 大谷 博, 山崎 健史, 天野 良亮, 田中 浩明, 六車 一哉, 八代 正和, 平川 弘聖, 大平 雅一

    癌と化学療法   44 ( 12 )   1523 - 1525   2017.11( ISSN:0385-0684

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    症例は58歳、男性。肛門痛、血便を主訴に他院を受診し、前立腺浸潤を伴う直腸癌と診断、人工肛門造設術を施行され、術前化学療法としてmFOLFOX6を6コース施行後、手術目的に当院を紹介受診となった。術前評価はPRであったが前立腺の浸潤は残存していると判断し、腹腔鏡下に腹会陰式直腸切断術、前立腺合併切除、尿道膀胱吻合による尿路再建を行い、術後第10病日に軽快退院となった。術後2年を経過した現在、明らかな排尿障害、残尿は認めず無再発生存中である。本術式は良好な術野が得られ、確実な切除が得られる点で非常に有用な術式であると思われた。(著者抄録)

  • Adverse Effects of Low Preoperative Skeletal Muscle Mass in Patients Undergoing Gastrectomy for Gastric Cancer Reviewed

    Sakurai Katsunobu, Kubo Naoshi, Tamura Tatsuro, Toyokawa Takahiro, Amano Ryosuke, Tanaka Hiroaki, Muguruma Kazuya, Yashiro Masakazu, Maeda Kiyoshi, Hirakawa Kosei, Ohira Masaichi

    ANNALS OF SURGICAL ONCOLOGY   24 ( 9 )   2712 - 2719   2017.09( ISSN:1068-9265

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    DOI: 10.1245/s10434-017-5875-6

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  • Adverse Effects of Low Preoperative Skeletal Muscle Mass in Patients Undergoing Gastrectomy for Gastric Cancer Reviewed

    Katsunobu Sakurai, Naoshi Kubo, Tatsuro Tamura, Takahiro Toyokawa, Ryosuke Amano, Hiroaki Tanaka, Kazuya Muguruma, Masakazu Yashiro, Kiyoshi Maeda, Kosei Hirakawa, Masaichi Ohira

    ANNALS OF SURGICAL ONCOLOGY   24 ( 9 )   2712 - 2719   2017.09( ISSN:1068-9265 ( eISSN:1534-4681

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    Objective. The aim of this study was to determine the impact of preoperative skeletal muscle mass on short- and long-term outcomes of patients with gastric cancer (GC) who undergo gastrectomy.
    Methods. A total of 569 patients subjected to gastrectomy for GC at our institution between January 2007 and December 2013 were reviewed and skeletal muscle index (SMI) was measured via cross-sectional, image-based muscle assessment. Computed tomography (CT) and the volume analyzer SYNAPSE VINCENT were required. Patients were divided into two groups, with the first quartile serving as the cut-point for both men and women. Clinicopathologic features and short- and long-term outcomes were compared.
    Results. In multivariate analysis, SMI emerged as an independent predictor of 5 year overall survival (OS) and cancer-specific survival (CSS) in patients with GC. In subgroup analysis, by stage, patients with stage I disease and low (vs. high) SMI demonstrated significantly worse 5 year OS. The incidence of postoperative complications did not differ significantly by group.
    Conclusions. Preoperative SMI, measured in cross-section using CT, is a useful nutritional determinant that may predict OS and CSS in patients with GC who undergo gastrectomy. In our view, nutritional support for sarcopenic patients with stage I GC, aimed at retaining or adding skeletal muscle mass, may improve survival. Our analysis showed no relationship between preoperative SMI and postoperative complications.

    DOI: 10.1245/s10434-017-5875-6

    PubMed

  • Cancer-associated fibroblasts induce cancer cell apoptosis that regulates invasion mode of tumours Reviewed

    Itoh G., Chida S., Yanagihara K., Yashiro M., Aiba N., Tanaka M.

    ONCOGENE   36 ( 31 )   4434 - 4444   2017.08( ISSN:0950-9232

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    DOI: 10.1038/onc.2017.49

  • Cancer-associated fibroblasts induce cancer cell apoptosis that regulates invasion mode of tumours. Reviewed

    Itoh G, Chida S, Yanagihara K, Yashiro M, Aiba N, Tanaka M

    Oncogene   36 ( 31 )   4434 - 4444   2017.08( ISSN:0950-9232

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    DOI: 10.1038/onc.2017.49

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  • Activation of Transforming Growth Factor Beta 1 Signaling in Gastric Cancer-associated Fibroblasts Increases Their Motility, via Expression of Rhomboid 5 Homolog 2, and Ability to Induce Invasiveness of Gastric Cancer Cells Reviewed

    Ishimoto Takatsugu, Miyake Keisuke, Nandi Tannistha, Yashiro Masakazu, Onishi Nobuyuki, Huang Kie Kyon, Lin Suling Joyce, Kalpana Ramnarayanan, Tay Su Ting, Suzuki Yuka, Cho Byoung Chul, Kuroda Daisuke, Arima Kota, Izumi Daisuke, Iwatsuki Masaaki, Baba Yoshifumi, Oki Eiji, Watanabe Masayuki, Saya Hideyuki, Hirakawa Kosei, Baba Hideo, Tan Patrick

    GASTROENTEROLOGY   153 ( 1 )   191 - +   2017.07( ISSN:0016-5085

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    DOI: 10.1053/j.gastro.2017.03.046

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  • Activation of Transforming Growth Factor Beta 1 Signaling in Gastric Cancer-associated Fibroblasts Increases Their Motility, via Expression of Rhomboid 5 Homolog 2, and Ability to Induce Invasiveness of Gastric Cancer Cells Reviewed

    Takatsugu Ishimoto, Keisuke Miyake, Tannistha Nandi, Masakazu Yashiro, Nobuyuki Onishi, Kie Kyon Huang, Suling Joyce Lin, Ramnarayanan Kalpana, Su Ting Tay, Yuka Suzuki, Byoung Chul Cho, Daisuke Kuroda, Kota Arima, Daisuke Izumi, Masaaki Iwatsuki, Yoshifumi Baba, Eiji Oki, Masayuki Watanabe, Hideyuki Saya, Kosei Hirakawa, Hideo Baba, Patrick Tan

    GASTROENTEROLOGY   153 ( 1 )   191 - 204.e16   2017.07( ISSN:0016-5085 ( eISSN:1528-0012

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    BACKGROUND & AIMS: Fibroblasts that interact with cancer cells are called cancer-associated fibroblasts (CAFs), which promote progression of different tumor types. We investigated the characteristics and functions of CAFs in diffuse-type gastric cancers (DGCs) by analyzing features of their genome and gene expression patterns. METHODS: We isolated CAFs and adjacent non-cancer fibroblasts (NFs) from 110 gastric cancer (GC) tissues from patients who underwent gastrectomy in Japan from 2008 through 2016. Cells were identified using specific markers of various cell types by immunoblot and flow cytometry. We selected pairs of CAFs and NFs for whole-exome and RNA sequencing analyses, and compared expression of specific genes using quantitative reverse transcription PCR. Protein levels and phosphorylation were compared by immunoblot and immunofluorescence analyses. Rhomboid 5 homolog 2 (RHBDF2) was overexpressed from a transgene in fibroblasts or knocked down using small interfering RNAs. Motility and invasiveness of isolated fibroblasts and GC cell lines (AGS, KATOIII, MKN45, NUGC3, NUGC4, OCUM-2MD3 and OCUM-12 cell lines) were quantified by real-time imaging analyses. We analyzed 7 independent sets of DNA microarray data from patients with GC and associated expression levels of specific genes with patient survival times. Nude mice were given injections of OCUM-2MD3 in the stomach wall; tumors and metastases were collected and analyzed by immunohistochemistry. RESULTS: Many of the genes with increased expression in CAFs compared with NFs were associated with transforming growth factor beta 1 (TGFB1) activity. When CAFs were cultured in extracellular matrix, they became more motile than NFs; DGC cells incubated with CAFs were also more motile and invasive in vitro than DGC cells not incubated with CAFs. When injected into nude mice, CAF-incubated DGC cells invaded a greater number of lymphatic vessels than NF-incubated DGC cells. We identified RHBDF2 as a gene overexpressed in CAFs compared with NFs. Knockdown of RHBDF2 in CAFs reduced their elongation and motility in response to TGFB1, whereas overexpression of RHBDF2 in NFs increased their motility in extracellular matrix. RHBDF2 appeared to regulate oncogenic and non-canonical TGFB1 signaling. Knockdown of RHBDF2 in CAFs reduced cleavage of the TGFB receptor 1 (TGFBR1) by ADAM metallopeptidase domain 17 (ADAM17 or TACE) and reduced expression of genes that regulate motility. Incubation of NFs with in interleukin 1 alpha (IL1A), IL1B or tumor necrosis factor, secreted by DGCs, increased fibroblast expression of RHBDF2. Simultaneous high expression of these cytokines in GC samples was associated with shorter survival times of patients. CONCLUSIONS: In CAFs isolated from human DGCs, we observed increased expression of RHBDF2, which regulates TGFB1 signaling. Expression of RHBDF2 in fibroblasts is induced by inflammatory cytokines (such as IL1A, IL1B, and tumor necrosis factor) secreted by DGCs. RHBDF2 promotes cleavage of TGFBR1 by activating TACE and motility of CAFs in response to TGFB1. These highly motile CAFs induce DGCs to invade extracellular matrix and lymphatic vessels in nude mice.

    DOI: 10.1053/j.gastro.2017.03.046

    PubMed

  • Interaction between the malignant melanoma cell of the primary lesion and the metastatic lesion Reviewed

    Hatano Takaharu, Motomura HIsashi, Fujikawa Heishiro, Yashiro Masakazu, Kitayama Kishu

    CANCER RESEARCH   77   2017.07( ISSN:0008-5472

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    DOI: 10.1158/1538-7445.AM2017-2985

  • Clinicopathologic significance of the CXCL1-CXCR2 axis in the tumor microenvironment of gastric carcinoma Reviewed

    Kasashima Hiroaki, Yashiro Masakazu, Nakamae Hirohisa, Masuda Go, Kinoshita Haruhito, Morisaki Tamami, Fukuoka Tatsunari, Hasegawa Tsuyoshi, Nakane Takahiko, Hino Masayuki, Hirakawa Kosei, Ohira Masaichi

    PLOS ONE   12 ( 6 )   e0178635   2017.06( ISSN:1932-6203

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    DOI: 10.1371/journal.pone.0178635

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  • Immunoregulatory Function of Lymphatic Endothelial Cells in Tumor-draining Lymph Nodes of Human Gastric Cancer Reviewed

    Tokumoto Mao, Tanaka Hiroaki, Tauchi Yukie, Tamura Tatsuro, Toyokawa Takahiro, Kimura Kenjiro, Muguruma Kazuya, Yashiro Masakazu, Maeda Kiyoshi, Hirakawa Kosei, Ohira Masaichi

    ANTICANCER RESEARCH   37 ( 6 )   2875 - 2883   2017.06( ISSN:0250-7005

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    DOI: 10.21873/anticanres.11640

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  • Immunoregulatory Function of Lymphatic Endothelial Cells in Tumor-draining Lymph Nodes of Human Gastric Cancer Reviewed

    Mao Tokumoto, Hiroaki Tanaka, Yukie Tauchi, Tatsuro Tamura, Takahiro Toyokawa, Kenjiro Kimura, Kazuya Muguruma, Masakazu Yashiro, Kiyoshi Maeda, Kosei Hirakawa, Masaichi Ohira

    ANTICANCER RESEARCH   37 ( 6 )   2875 - 2883   2017.06( ISSN:0250-7005 ( eISSN:1791-7530

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    Background/Aim: Lymph node metastasis is the most important prognostic factor for patients with gastric cancer. Increasing evidence suggests that lymphatic endothelial cells (LECs) regulate immune responses. The aim of this study was to examine the effect of LECs on the activation of CD4(+) T cells. Materials and Methods: We examined the impact of cancer cells on the phenotype and production of cytokines of LECs derived from tumor-draining lymph nodes. Results: We showed that LECs inhibited CD4(+) T cell production of cytokines, such as IL-2, IL-10, and INF-gamma. The mRNA expression of programmed death-ligand 1 (PD-L1) and indoleamine 2, 3-dioxygenase (IDO) by LECs were significantly up-regulated when the LECs and CD4(+) T cells were co-cultured with cells of the gastric cancer cell line, OCUM12. Conclusion: Intranodal LECs may be a key player in the induction of immune tolerance against cancer and in facilitating metastasis through lymphatic vessels in gastric cancer.

    DOI: 10.21873/anticanres.11640

    PubMed

  • Clinical experience of S-1 and oxaliplatin (SOX) as the first-line chemotherapy for metastatic/recurrent gastric cancer Reviewed

    Takahiro Toyokawa, Tatsuro Tamura, Masatsune Shibutani, Goh Ohira, Sadaaki Yamazoe, Kenjiro Kimura, Hisashi Nagahara, Ryosuke Amano, Hiroaki Tanaka, Kazuya Muguruma, Masakazu Yashiro, Kosei Hirakawa, Masaichi Ohira

    Japanese Journal of Cancer and Chemotherapy   44 ( 5 )   405 - 408   2017.05( ISSN:0385-0684

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    We retrospectively investigated the efficacy and safety of S-1 and oxaliplatin (SOX) as the first-line chemotherapy in patients with metastatic/recurrent gastric cancer. A total of 27 patients who received SOX as the first-line chemotherapy in our hospital were considered for the study. The SOX chemotherapy schedule consisted of 1 course every 3 weeks. S-1 was administered orally, at 80-120 mg-body, every day for 14 days. Oxaliplatin was infused at 100mg/m2 on day 1 of each course. The median number of treatment courses was 7. The response rate and disease control rate were 47.6% and 76.2%, respectively. The observed adverse events of Grade 3 or more included neutropenia (33.3%)
    peripheral neuropathy and anorexia (11.1%)
    thrombocytopenia (7.4%)
    and anemia, diarrhea, fatigue, and hypercalcemia (3.7%). The median overall survival was not achieved, and the 1-year survival rate was 63.2%. Therefore, SOX is an effective and feasible first-line chemotherapy that is easily available for ambulatory treatment of patients with metastatic/recurrent gastric cancer.

    PubMed

  • [Clinical Experience of S-1 and Oxaliplatin(SOX)as the First-Line Chemotherapy for Metastatic/Recurrent Gastric Cancer]. Reviewed

    Toyokawa T, Tamura T, Shibutani M, Ohira G, Yamazoe S, Kimura K, Nagahara H, Amano R, Tanaka H, Muguruma K, Yashiro M, Hirakawa K, Ohira M

    Gan to kagaku ryoho. Cancer & chemotherapy   44 ( 5 )   405 - 408   2017.05( ISSN:0385-0684

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  • 進行再発胃癌に対するSOX療法の治療成績 Reviewed

    豊川 貴弘, 田村 達郎, 渋谷 雅常, 大平 豪, 山添 定明, 木村 健二郎, 永原 央, 天野 良亮, 田中 浩明, 六車 一哉, 八代 正和, 平川 弘聖, 大平 雅一

    (株)癌と化学療法社 癌と化学療法   44 ( 5 )   405 - 408   2017.05( ISSN:0385-0684

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    進行再発胃癌に対する一次治療としてのS-1+oxaliplatin(SOX)療法の有効性と安全性について検討した。対象は当科でSOX療法を施行した進行再発胃癌27例である。投与方法はoxaliplatin 100mg/m2を第1日目に点滴静注、S-1 80〜120mg/bodyを2週投与1週休薬で投与し、3週1コースとした。投与コース中央値は7コースで、奏効率47.6%、病勢コントロール率は76.2%であった。Grade 3以上の有害事象は、好中球減少33.3%、末梢神経障害、食欲不振11.1%、血小板減少7.4%、貧血、下痢、疲労、高カルシウム血症を3.7%に認めた。生存期間中央値には到達せず、1年生存率は63.2%であった。実地臨床においてもSOX療法の治療効果は良好で、外来で安全に施行可能であった。(著者抄録)

  • [Clinical Experience of S-1 and Oxaliplatin(SOX)as the First-Line Chemotherapy for Metastatic/Recurrent Gastric Cancer]. Reviewed

    Toyokawa T, Tamura T, Shibutani M, Ohira G, Yamazoe S, Kimura K, Nagahara H, Amano R, Tanaka H, Muguruma K, Yashiro M, Hirakawa K, Ohira M

    Gan to kagaku ryoho. Cancer & chemotherapy   44 ( 5 )   405 - 408   2017.05( ISSN:0385-0684

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  • 進行再発胃癌に対するSOX療法の治療成績 Reviewed

    豊川 貴弘, 田村 達郎, 渋谷 雅常, 大平 豪, 山添 定明, 木村 健二郎, 永原 央, 天野 良亮, 田中 浩明, 六車 一哉, 八代 正和, 平川 弘聖, 大平 雅一

    癌と化学療法   44 ( 5 )   405 - 408   2017.05( ISSN:0385-0684

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    進行再発胃癌に対する一次治療としてのS-1+oxaliplatin(SOX)療法の有効性と安全性について検討した。対象は当科でSOX療法を施行した進行再発胃癌27例である。投与方法はoxaliplatin 100mg/m2を第1日目に点滴静注、S-1 80~120mg/bodyを2週投与1週休薬で投与し、3週1コースとした。投与コース中央値は7コースで、奏効率47.6%、病勢コントロール率は76.2%であった。Grade 3以上の有害事象は、好中球減少33.3%、末梢神経障害、食欲不振11.1%、血小板減少7.4%、貧血、下痢、疲労、高カルシウム血症を3.7%に認めた。生存期間中央値には到達せず、1年生存率は63.2%であった。実地臨床においてもSOX療法の治療効果は良好で、外来で安全に施行可能であった。(著者抄録)

  • C-Reactive Protein Indicates Early Stage of Postoperative Infectious Complications in Patients Following Minimally Invasive Esophagectomy Reviewed

    Miki Yuichiro, Toyokawa Takahiro, Kubo Naoshi, Tamura Tatsuro, Sakurai Katsunobu, Tanaka Hiroaki, Muguruma Kazuya, Yashiro Masakazu, Hirakawa Kosei, Ohira Masaichi

    WORLD JOURNAL OF SURGERY   41 ( 3 )   796 - 803   2017.03( ISSN:0364-2313

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    DOI: 10.1007/s00268-016-3803-8

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  • C-Reactive Protein Indicates Early Stage of Postoperative Infectious Complications in Patients Following Minimally Invasive Esophagectomy Reviewed

    Yuichiro Miki, Takahiro Toyokawa, Naoshi Kubo, Tatsuro Tamura, Katsunobu Sakurai, Hiroaki Tanaka, Kazuya Muguruma, Masakazu Yashiro, Kosei Hirakawa, Masaichi Ohira

    WORLD JOURNAL OF SURGERY   41 ( 3 )   796 - 803   2017.03( ISSN:0364-2313 ( eISSN:1432-2323

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    Esophagectomy for patients with esophageal cancer is associated with high rate of postoperative infectious complications (PICs). Although minimally invasive esophagectomy (MIE) could reduce the rate of PICs, its incidence cannot be ignored. Early detection of PICs may be beneficial in clinical settings. We investigated whether systemic inflammation markers, such as C-reactive protein (CRP) and white blood cell count (WBC), are useful for the early detection of PICs.
    We reviewed 158 patients who underwent MIE from 2000 to 2015 and assessed PIC incidence and severity. The value of CRP and WBC in the early detection of PICs was evaluated by receiver operating characteristics analyses. Univariate and multivariate analyses were performed to identify severe PICs risk factors (Clavien-Dindo classification, grade IIIa or higher).
    Thirty patients developed PICs: grades III, IV, and V in 19 (12.0%), 9 (5.7%), and 2 (1.3%) patients, respectively. CRP on 4POD showed the highest value for detection of PICs (AUC = 072). Cutoff value of CRP on 4POD was determined as 11.1 (mg/dL), in which the sensitivity and specificity were the maximum value. The univariate analysis revealed that sex (male), operation time (&gt;= 597 min), and CRP on 4POD (&gt;= 11.1 mg/dL) were significant factors for detecting PICs. Multivariate analyses showed that operation time (&gt;= 597) and CRP on 4POD (&gt;= 11.1 mg/dL) were independent significant factors for detecting PICs.
    CRP on 4POD &gt;= 11.1 mg/dL was an independent PICs risk factor in patients who underwent MIE. It will be beneficial for the early detection of PICs following MIE.

    DOI: 10.1007/s00268-016-3803-8

    PubMed

  • Cervical chylous leakage following esophagectomy treated by intranodal lipiodol lymphangiography: a case report Reviewed

    Tamura Tatsuro, Kubo Naoshi, Yamamoto Akira, Sakurai Katsunobu, Toyokawa Takahiro, Tanaka Hiroaki, Muguruma Kazuya, Yashiro Masakazu, Maeda Kiyoshi, Hirakawa Kosei, Ohira Masaichi

    BMC SURGERY   17 ( 1 )   20   2017.02( ISSN:1471-2482

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    DOI: 10.1186/s12893-017-0218-x

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  • Cervical chylous leakage following esophagectomy treated by intranodal lipiodol lymphangiography: a case report Reviewed

    Tatsuro Tamura, Naoshi Kubo, Akira Yamamoto, Katsunobu Sakurai, Takahiro Toyokawa, Hiroaki Tanaka, Kazuya Muguruma, Masakazu Yashiro, Kiyoshi Maeda, Kosei Hirakawa, Masaichi Ohira

    BMC SURGERY   17 ( 1 )   20   2017.02( ISSN:1471-2482

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    Background: Chylous leakage is a well-known complication after esophagectomy, but cervical chylous leakage is relatively rare, and considerable controversy remains regarding the appropriate management strategies. We herein report a case of cervical chylous leakage treated successfully by lipiodol lymphangiography.
    Case presentation: The patient, a 70-year-old man with middle thoracic esophageal cancer, underwent radical esophagectomy with 3-field lymph node dissection and subsequently developed cervical chylous leakage. From the second postoperative day (POD2), the amount of fluid in the cervical drainage tube increased by 200-300 ml/day. We started octreotide (300 mu g/day) on POD5 and etilefrine (120 mg/day) on the POD6. However, the amount of cervical discharge did not decrease. We performed lipiodol lymphangiography on POD8. Thereafter, the amount of cervical discharge finally began to decrease. We removed the drainage tube on POD13, and the patient was discharged from the hospital on POD23.
    Conclusions: Our case suggests the clinical efficacy of lipiodol lymphangiography for cervical chylous leakage after esophagectomy.

    DOI: 10.1186/s12893-017-0218-x

    PubMed

  • Mesothelial Cells Create a Novel Tissue Niche That Facilitates Gastric Cancer Invasion Reviewed

    Tanaka Masamitsu, Kuriyama Sei, Itoh Go, Maeda Daichi, Goto Akiteru, Tamiya Yutaro, Yanagihara Kazuyoshi, Yashiro Masakazu, Aiba Namiko

    CANCER RESEARCH   77 ( 3 )   684 - 695   2017.02( ISSN:0008-5472

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    DOI: 10.1158/0008-5472.CAN-16-0964

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  • Mesothelial Cells Create a Novel Tissue Niche That Facilitates Gastric Cancer Invasion Reviewed

    Masamitsu Tanaka, Sei Kuriyama, Go Itoh, Daichi Maeda, Akiteru Goto, Yutaro Tamiya, Kazuyoshi Yanagihara, Masakazu Yashiro, Namiko Aiba

    CANCER RESEARCH   77 ( 3 )   684 - 695   2017.02( ISSN:0008-5472 ( eISSN:1538-7445

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    Peritoneal mesothelial cells (PMC) cover organ surfaces in the abdominal cavity. In this study, lineage tracing revealed that the PMCs guide cancer cell invasion in the gastric wall and in peritoneal metastatic lesions. Serosal PMCs covering the stomach surface entered the gastric wall to create a novel niche that favored gastric cancer cell invasion. PMC infiltration was induced by incorporation of cancer cell-derived, Wnt3a-containing extracellular vesicles. Infiltrated PMCs in turn promoted subserosal invasion of cancer cells. Mutual attraction between cancer cells and PMCs accelerated tumor invasion in the gastric wall, and PMC-led cancer cell invasion in disseminated tumors within the abdominal wall and diaphragm. Addition of the carboxyl terminus of Dickkopf-1 attenuated directional invasion of PMCs toward cancer cells both in vitro and in the gastric wall in vivo. PMCs were sensitive to the aldehyde dehydrogenase (ALDH) inhibitor disulfiram (DSF), as ALDH activity is elevated in PMCs. Wnt3a upregulated ALDH, and addition of DSF inhibited the invasive properties of PMCs, whereas DSF pretreatment suppressed gastric infiltration of PMCs and subserosal invasion by cancer cells. Our results suggest that stabilization of PMCs may become an effective therapy for the prevention of local invasion and metastasis of gastric cancer. (C) 2016 AACR.

    DOI: 10.1158/0008-5472.CAN-16-0964

    PubMed

  • Prognostic significance of baseline nutritional index for patients with esophageal squamous cell carcinoma after radical esophagectomy Reviewed

    Kubo Naoshi, Ohira Masaichi, Tamura Tatsuro, Sakurai Katsunobu, Toyokawa Takahiro, Tanaka Hiroaki, Yashiro Masakazu, Yamashita Yoshito, Hirakawa Kosei

    ESOPHAGUS   14 ( 1 )   84 - 90   2017.01( ISSN:1612-9059

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    DOI: 10.1007/s10388-016-0548-2

  • 根治的食道切除後の食道扁平上皮癌患者における術前の予後指標としての栄養指数の意義(Prognostic significance of baseline nutritional index for patients with esophageal squamous cell carcinoma after radical esophagectomy) Reviewed

    Kubo Naoshi, Ohira Masaichi, Tamura Tatsuro, Sakurai Katsunobu, Toyokawa Takahiro, Tanaka Hiroaki, Yashiro Masakazu, Yamashita Yoshito, Hirakawa Kosei

    シュプリンガー・ジャパン(株) Esophagus   14 ( 1 )   84 - 90   2017.01( ISSN:1612-9059

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    食道扁平上皮癌(ESCC)に対する根治的食道切除後の短期および長期成績に、術前のprognostic nutritional index(PNI)がどのような影響を及ぼすか後ろ向きに検討した。対象はESCC患者202例(男性162例、女性40例、年齢43〜87歳)で、PNIは10×血清アルブミン値(g/dL)+0.005×総リンパ球計数(per mm3)で計算した。平均PNIは48.9±4.6で、多重ロジスティック回帰分析における受信者動作特性曲線下面積は0.5367であった。予測5年生存率はPNIが44.1の場合に最適であったためカットオフ値を44とし、患者をPNI 44以上の高PNI群(173例)と44未満の低PNI群(29例)に分類した。全生存率(OS)および無再発生存率(RFS)は高PNI群に比して低PNI群で有意に不良で、5年OSとRFSは高PNI群で67.2%と61.5%、低PNI群で41.2%と38.8%であった。術後合併症は両群で差は認められなかった。OSおよびRFSに対するCox比例ハザードモデルを用いた単変量および多変量解析では、PNIが両者に対する重要な予後因子であることが明らかとなった。PNIは根治手術を予定されているESCC患者に対する実践的予後マーカーであり、低PNIのESCC患者に対する術後の腫瘍再発に対する注意深いフォローアップが必要であることが示唆された。

  • 根治的食道切除後の食道扁平上皮癌患者における術前の予後指標としての栄養指数の意義(Prognostic significance of baseline nutritional index for patients with esophageal squamous cell carcinoma after radical esophagectomy) Reviewed

    Kubo Naoshi, Ohira Masaichi, Tamura Tatsuro, Sakurai Katsunobu, Toyokawa Takahiro, Tanaka Hiroaki, Yashiro Masakazu, Yamashita Yoshito, Hirakawa Kosei

    Esophagus   14 ( 1 )   84 - 90   2017.01( ISSN:1612-9059

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    食道扁平上皮癌(ESCC)に対する根治的食道切除後の短期および長期成績に、術前のprognostic nutritional index(PNI)がどのような影響を及ぼすか後ろ向きに検討した。対象はESCC患者202例(男性162例、女性40例、年齢43~87歳)で、PNIは10×血清アルブミン値(g/dL)+0.005×総リンパ球計数(per mm3)で計算した。平均PNIは48.9±4.6で、多重ロジスティック回帰分析における受信者動作特性曲線下面積は0.5367であった。予測5年生存率はPNIが44.1の場合に最適であったためカットオフ値を44とし、患者をPNI 44以上の高PNI群(173例)と44未満の低PNI群(29例)に分類した。全生存率(OS)および無再発生存率(RFS)は高PNI群に比して低PNI群で有意に不良で、5年OSとRFSは高PNI群で67.2%と61.5%、低PNI群で41.2%と38.8%であった。術後合併症は両群で差は認められなかった。OSおよびRFSに対するCox比例ハザードモデルを用いた単変量および多変量解析では、PNIが両者に対する重要な予後因子であることが明らかとなった。PNIは根治手術を予定されているESCC患者に対する実践的予後マーカーであり、低PNIのESCC患者に対する術後の腫瘍再発に対する注意深いフォローアップが必要であることが示唆された。

  • Prognostic significance of baseline nutritional index for patients with esophageal squamous cell carcinoma after radical esophagectomy Reviewed

    Naoshi Kubo, Masaichi Ohira, Tatsuro Tamura, Katsunobu Sakurai, Takahiro Toyokawa, Hiroaki Tanaka, Masakazu Yashiro, Yoshito Yamashita, Kosei Hirakawa

    ESOPHAGUS   14 ( 1 )   84 - 90   2017.01( ISSN:1612-9059 ( eISSN:1612-9067

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    Background Radical esophagectomy is the cornerstone of curative treatment for patients with resectable esophageal squamous cell carcinoma (ESCC). Patient survival after surgery for ESCC is mainly associated with pathological tumor progression. Recently, the impact of baseline immune-nutritional status of various types of patients with cancer on survival has been highlighted. The purpose of the present study was to investigate the association between the baseline prognostic nutritional index (PNI) and postoperative short-and long-term results after esophagectomy for patients with ESCC. Methods In total, 202 patients with ESCC who underwent radical esophagectomy at our institution between 2002 and 2010 were enrolled. PNI was calculated as 10x serum albumin (g/dL) + 0.005 x total lymphocyte counts (per mm3). Receiver operating characteristic (ROC) curves were generated for multiple logistic regression analysis using 5-year overall survival as the endpoint to determine an optimal PNI cutoff value, in which patients were classified into two groups: high PNI and low PNI. We evaluated the significance of PNI on postoperative morbidity and long-term survival using univariate and multivariate analyses. Results The mean PNI was 48.9 +/- 4.6 (range 37.2-64.0). The area under the ROC curve in multiple logistic regression analysis was 0.5367. The projected 5-year survival rate was optimal at a PNI of 44.1. Hence, the PNI cutoff point was set at 44, with subjects classified by PNI level into the low (PNI &lt; 44) or high (PNI = 44) PNI groups. Of 202 patients, 173 (85.7 %) and 29 (14.3 %) were classified as having high and low PNI, respectively. No significant differences were noted between the two groups regarding patient background, including age, sex, pT, pN, and pStage, or postoperative complications. However, overall survival (OS) and relapse-free survival (RFS) were significantly worse in the low PNI group than in the high PNI group. The 5-year OS and RFS rates in the high PNI vs. low PNI groups were 67.2 vs. 41.2 % (P = 0.007) and 61.5 vs. 38.8 % (P = 0.008), respectively. Multivariate analysis revealed that PNI was a significant prognostic factor for both OS (hazard ratio, 1.826; 95 % confidence interval, 1.015-3.285; P = 0.044) and RFS (hazard ratio, 1.862; 95 % confidence interval, 1.121-3.095; P = 0.016). Conclusion Preoperative PNI is an independent prognostic marker of both OS and RFS for patients with potentially curative ESCC. A careful follow-up for tumor recurrence after surgery is required for ESCC patients with low PNI.

    DOI: 10.1007/s10388-016-0548-2

  • Effect of glucose metabolism-related enzymes on the proliferation of gastric cancer cells in hypoxic microenvironment Reviewed

    Kitayama Kishu, Muguruma Kazuya, Hirakawa Kosei, Ohira Masaichi, Yashiro Masakazu, Morisaki Tamami, Okuno Tomohisa, Miki Yuichiro, Kasashima Hiroaki, Masuda Go, Toyokawa Takahiro, Tanaka Hiroaki

    Japanese Society for Molecular Tumor Marker Research, Japan Journal of Molecular Tumor Marker Research   32 ( 0 )   2017

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    DOI: 10.11241/jsmtmr.32.55

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  • 胃癌診療における腫瘍マーカー Reviewed

    八代 正和

    日本分子腫瘍マーカー研究会 日本分子腫瘍マーカー研究会誌   32 ( 0 )   2017

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    DOI: 10.11241/jsmtmr.32.10

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  • Clinicopathologic significance of the CXCL1-CXCR2 axis in the tumor microenvironment of gastric carcinoma Reviewed

    Hiroaki Kasashima, Masakazu Yashiro, Hirohisa Nakamae, Go Masuda, Haruhito Kinoshita, Tamami Morisaki, Tatsunari Fukuoka, Tsuyoshi Hasegawa, Takahiko Nakane, Masayuki Hino, Kosei Hirakawa, Masaichi Ohira

    PLOS ONE   12 ( 6 )   e0178635   2017( ISSN:1932-6203

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    Purpose
    It was reported that the chemokine (C-X-C motif) ligand 1 (CXCL1) from cancer cells stimulated the recruitment of bone marrow-derived mesenchymal cells (BM-MCs) into tumor stroma via chemokine (C-X-C motif) receptor 2 (CXCR2) signaling. We conducted this retrospective study to determine the clinicopathologic significance of the CXCL1-CXCR2 axis in human gastric cancer.
    Methods
    The correlations between the clinicopathological features of 270 primary gastric carcinomas and CXCL1 in cancer cells and CXCR2 in stromal cells were analyzed in immunohistochemical studies. The effect of gastric cancer cells on the expression of CXCR2 in BM-MCs was examined using diffuse-type gastric cancer cell lines in vitro.
    Results
    The expression of CXCL1 in cancer cells was correlated with T invasion (T2-T4), lymph node metastasis, lymphatic invasion, venous invasion, peritoneal cytology, peritoneal metastasis and CXCR2 expression in stromal cells. The expression of CXCR2 in stromal cells was correlated with macroscopic type-4 cancers, histological type, T invasion (T2-T4), lymph node metastasis, lymphatic invasion, infiltration, peritoneal cytology, peritoneal metastasis and CD271 expression in stromal cells. The overall survival of patients with CXCL1 and CXCR2-positive cancer was poorer than that of the patients with negative cancer. Both CXCL1 expression in cancer cells and CXCR2 expression in stromal cells were independent prognostic factors for gastric cancer patients.
    Conclusion
    The expressions of CXCL1 in cancer cells and CXCR2 in stromal cells are useful prognostic factors for gastric cancer patients.

    DOI: 10.1371/journal.pone.0178635

    PubMed

  • Effect of glucose metabolism-related enzymes on the proliferation of gastric cancer cells in hypoxic microenvironment Reviewed

    Kitayama Kishu, Yashiro Masakazu, Morisaki Tamami, Okuno Tomohisa, Miki Yuichiro, Kasashima Hiroaki, Masuda Go, Toyokawa Takahiro, Tanaka Hiroaki, Muguruma Kazuya, Hirakawa Kosei, Ohira Masaichi

    Japan Journal of Molecular Tumor Marker Research   32 ( 0 )   55   2017( eISSN:24338575

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    DOI: 10.11241/jsmtmr.32.55

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  • 胃癌診療における腫瘍マーカー Reviewed

    八代 正和

    日本分子腫瘍マーカー研究会誌   32 ( 0 )   10   2017( eISSN:24338575

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    DOI: 10.11241/jsmtmr.32.10

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  • Identification of the novel molecules mediating gastric cancer invasion based on genomic analysis of cancer-associated fibroblasts Reviewed

    Ishimoto T., Miyake K., Nandi T., Yashiro M., Huang K. K., Arima K., Izumi D., Baba Y., Baba H., Tan P.

    ANNALS OF ONCOLOGY   27   2016.12( ISSN:0923-7534

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  • 癌宿主因子における予後および効果予測 Reviewed

    後藤 航, 柏木 伸一郎, 浅野 有香, 渋谷 雅常, 木村 健二郎, 豊川 貴弘, 天野 良亮, 田中 浩明, 六車 一哉, 高島 勉, 八代 正和, 小野田 尚佳, 前田 清, 平川 弘聖, 大平 雅一

    大道学館出版部 臨牀と研究   93 ( 12 )   1614 - 1615   2016.12( ISSN:0021-4965

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    癌宿主因子における炎症指標の有用性について検証した。グラスゴー予後予測スコアはCRP値とアルブミン値によって算出されるが、その他の指標はそれぞれの因子の絶対値の組み合わせで求められる。カットオフ値はROC解析で求めることが多く、評価項目は全生存期間または無病生存期間に関連して測定されることが多い。すべての指標において基準とされる数値は存在しない。末梢血から求められる炎症反応や栄養状態、免疫環境などの宿主因子は、有用な予後および治療効果予測因子である可能性が示唆された。

  • 癌宿主因子における予後および効果予測 Reviewed

    後藤 航, 柏木 伸一郎, 浅野 有香, 渋谷 雅常, 木村 健二郎, 豊川 貴弘, 天野 良亮, 田中 浩明, 六車 一哉, 高島 勉, 八代 正和, 小野田 尚佳, 前田 清, 平川 弘聖, 大平 雅一

    臨牀と研究   93 ( 12 )   1614 - 1615   2016.12( ISSN:0021-4965

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    癌宿主因子における炎症指標の有用性について検証した。グラスゴー予後予測スコアはCRP値とアルブミン値によって算出されるが、その他の指標はそれぞれの因子の絶対値の組み合わせで求められる。カットオフ値はROC解析で求めることが多く、評価項目は全生存期間または無病生存期間に関連して測定されることが多い。すべての指標において基準とされる数値は存在しない。末梢血から求められる炎症反応や栄養状態、免疫環境などの宿主因子は、有用な予後および治療効果予測因子である可能性が示唆された。

  • [A Case of Metastatic Lung Cancer from Colon Cancer with a Long Partial Response with Regorafenib Treatment]. Reviewed

    Iseki Y, Yashiro M, Shibutani M, Nagahara H, Maeda K, Matsutani S, Tamura T, Ohira G, Yamazoe S, Kimura K, Toyokawa T, Amano R, Tanaka H, Muguruma K, Hirakawa K, Ohira M

    Gan to kagaku ryoho. Cancer & chemotherapy   43 ( 12 )   2338 - 2340   2016.11( ISSN:0385-0684

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  • CXCL1-Chemokine (C-X-C Motif) Receptor 2 Signaling Stimulates the Recruitment of Bone Marrow-Derived Mesenchymal Cells into Diffuse-Type Gastric Cancer Stroma Reviewed

    Kasashima Hiroaki, Yashiro Masakazu, Nakamae Hirohisa, Kitayama Kisyu, Masuda Go, Kinoshita Haruhito, Fukuoka Tatsunari, Hasegawa Tsuyoshi, Nakane Takahiko, Hino Masayuki, Hirakawa Kosei, Ohira Masaichi

    AMERICAN JOURNAL OF PATHOLOGY   186 ( 11 )   3028 - 3039   2016.11( ISSN:0002-9440

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    DOI: 10.1016/j.ajpath.2016.07.024

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  • Elevated alpha1-acid glycoprotein in gastric cancer patients inhibits the anticancer effects of paclitaxel, effects restored by co-administration of erythromycin Reviewed

    Ohbatake Yoshinao, Fushida Sachio, Tsukada Tomoya, Kinoshita Jun, Oyama Katsunobu, Hayashi Hironori, Miyashita Tomoharu, Tajima Hidehiro, Takamura Hiroyuki, Ninomiya Itasu, Yashiro Masakazu, Hirakawa Kousei, Ohta Tetsuo

    CLINICAL AND EXPERIMENTAL MEDICINE   16 ( 4 )   585 - 592   2016.11( ISSN:1591-8890

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    DOI: 10.1007/s10238-015-0387-9

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  • レゴラフェニブにて18ヵ月間の長期PRが得られた大腸癌肺転移の1例 Reviewed

    井関 康仁, 八代 正和, 渋谷 雅常, 永原 央, 前田 清, 松谷 慎治, 田村 達郎, 大平 豪, 山添 定明, 木村 健二郎, 豊川 貴弘, 天野 良亮, 田中 浩明, 六車 一哉, 平川 弘聖, 大平 雅一

    (株)癌と化学療法社 癌と化学療法   43 ( 12 )   2338 - 2340   2016.11( ISSN:0385-0684

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    症例は66歳、女性。2005年12月、当科にてS状結腸癌に対してS状結腸切除術を施行。病理結果にてpT2N0M0、fStage Iであり、術後補助化学療法は施行せず経過観察していた。2011年11月にCEA 9.7ng/mLと上昇を認め、精査にて転移性肺癌を認めた。FOLFOX+bevacizumab(BV)療法を21コース、FOLFIRI+BV療法を6コース、XELOX+BV療法を13コース施行した。いずれのレジメンもprogressive disease(PD)となったため、fourth-lineとしてレゴラフェニブ療法を開始した。レゴラフェニブ開始前のレジメンにて手足症候群がみられたため、80mg/dayで開始した、Grade 2以上の副作用はでることなく投与開始後18ヵ月経過し、長期間partial response(PR)が持続し現在22コース施行中である。大腸癌肺転移再発症例に対してレゴラフェニブ投与により長期にわたるPRを得ることができた1例を経験した。(著者抄録)

  • [A Case of Metastatic Lung Cancer from Colon Cancer with a Long Partial Response with Regorafenib Treatment]. Reviewed

    Iseki Y, Yashiro M, Shibutani M, Nagahara H, Maeda K, Matsutani S, Tamura T, Ohira G, Yamazoe S, Kimura K, Toyokawa T, Amano R, Tanaka H, Muguruma K, Hirakawa K, Ohira M

    Gan to kagaku ryoho. Cancer & chemotherapy   43 ( 12 )   2338 - 2340   2016.11( ISSN:0385-0684

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    PubMed

  • [A Case of Metastatic Lung Cancer from Colon Cancer with a Long Partial Response with Regorafenib Treatment]. Reviewed

    Iseki Y, Yashiro M, Shibutani M, Nagahara H, Maeda K, Matsutani S, Tamura T, Ohira G, Yamazoe S, Kimura K, Toyokawa T, Amano R, Tanaka H, Muguruma K, Hirakawa K, Ohira M

    Gan to kagaku ryoho. Cancer & chemotherapy   43 ( 12 )   2338 - 2340   2016.11( ISSN:0385-0684

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    PubMed

  • Elevated alpha1-acid glycoprotein in gastric cancer patients inhibits the anticancer effects of paclitaxel, effects restored by co-administration of erythromycin Reviewed

    Yoshinao Ohbatake, Sachio Fushida, Tomoya Tsukada, Jun Kinoshita, Katsunobu Oyama, Hironori Hayashi, Tomoharu Miyashita, Hidehiro Tajima, Hiroyuki Takamura, Itasu Ninomiya, Masakazu Yashiro, Kousei Hirakawa, Tetsuo Ohta

    CLINICAL AND EXPERIMENTAL MEDICINE   16 ( 4 )   585 - 592   2016.11( ISSN:1591-8890 ( eISSN:1591-9528

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    Paclitaxel (PTX) which easily elutes into ascites is widely used to treat gastric cancer patients with peritoneal carcinomatosis (PC), but clinical outcomes are suboptimal. Increased concentrations of alpha 1-acid glycoprotein (AGP), an important drug-binding protein, have been reported in the plasma and ascites of cancer patients. This study sought to clarify whether AGP binds to PTX and alters its anticancer effects. AGP concentrations were measured in the serum and ascites of gastric cancer patients with PC and in the serum of healthy volunteers. The in vitro effects of AGP and AGP plus erythromycin (EM) on PTX were evaluated by MTT assays in the gastric cancer cell lines. We also measured AGP concentrations in the ascites of PC model mice and examined the effects of EM plus PTX on PC. The mean AGP concentrations in the serum and ascites of gastric cancer patients with PC were 1524 and 834 mu g/mL, respectively, higher than the mean AGP concentration of 650 mu g/mL observed in the sera of healthy volunteers. AGP &gt; 400 mu g/mL significantly suppressed the cell growth inhibitory effect of PTX in vitro, but the co-administration of EM restored it. Elevated AGP concentrations were observed in the ascites of PC model mice. Administration of PTX alone did not markedly diminish PC, whereas co-administration of PTX and EM significantly reduced PC (p = 0.011). AGP is an important regulatory factor modulating the anticancer activity of intraperitoneal PTX. The co-administration of PTX and EM may be effective in treating gastric cancer patients with PC.

    DOI: 10.1007/s10238-015-0387-9

    PubMed

  • CXCL1-Chemokine (C-X-C Motif) Receptor 2 Signaling Stimulates the Recruitment of Bone Marrow-Derived Mesenchymal Cells into Diffuse-Type Gastric Cancer Stroma Reviewed

    Hiroaki Kasashima, Masakazu Yashiro, Hirohisa Nakamae, Kisyu Kitayama, Go Masuda, Haruhito Kinoshita, Tatsunari Fukuoka, Tsuyoshi Hasegawa, Takahiko Nakane, Masayuki Hino, Kosei Hirakawa, Masaichi Ohira

    AMERICAN JOURNAL OF PATHOLOGY   186 ( 11 )   3028 - 3039   2016.11( ISSN:0002-9440 ( eISSN:1525-2191

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    Tumor stromal cells play a critical role in the progression of diffuse-type gastric cancer (DGC). The aim of this study was to clarify where tumor stomal cells originate from and which factor(s) recruits them into the tumor stroma. Immunodeficient mice with bone marrow transplantation from the cytomegalovirus enhancer/chicken beta-actin promoter-enhanced green fluorescent protein mice were used for the in vivo experiments. An in vitro study analyzed the chemotaxis-stimulating factor from DGC cells using bone marrow-derived mesenchymal cells (BM-MCs). The influences of chemokine (C-X-C motif) receptor 2 (CXCR2) inhibitor on the migration of BM-MCs were examined both in vitro and in vivo. BM-MCs frequently migrated into stroma of DGC in vivo. The number of migrating BM-MCs was increased by conditioned medium from DGC cells. CXCL1 from DGC cells stimulated the chemoattractant ability of BM-MCs. Both anti-CXCL1 antibody and CXCR2 inhibitor decreased the migration of BM-MCs, stimulated by DGC cells. A CXCR2 inhibitor, SB225002, reduced the recruitment of BM-MCs into the tumor microenvironment in vivo, decreasing tumor size and lymph node metastasis, and prolonging the survival of gastric tumor-bearing mice. These findings suggested that most tumor stromal cells in DGC might originate from BM-MCs. CXCL1 from DGC cells stimulates the recruitment of BM-MCs into tumor stroma via CXCR2 signaling of BM-MCs. Inhibition of BM-MC recruitment via the CXCL1-CXCR2 axis appears a promising therapy for DGC.

    DOI: 10.1016/j.ajpath.2016.07.024

    PubMed

  • レゴラフェニブにて18ヵ月間の長期PRが得られた大腸癌肺転移の1例 Reviewed

    井関 康仁, 八代 正和, 渋谷 雅常, 永原 央, 前田 清, 松谷 慎治, 田村 達郎, 大平 豪, 山添 定明, 木村 健二郎, 豊川 貴弘, 天野 良亮, 田中 浩明, 六車 一哉, 平川 弘聖, 大平 雅一

    癌と化学療法   43 ( 12 )   2338 - 2340   2016.11( ISSN:0385-0684

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    症例は66歳、女性。2005年12月、当科にてS状結腸癌に対してS状結腸切除術を施行。病理結果にてpT2N0M0、fStage Iであり、術後補助化学療法は施行せず経過観察していた。2011年11月にCEA 9.7ng/mLと上昇を認め、精査にて転移性肺癌を認めた。FOLFOX+bevacizumab(BV)療法を21コース、FOLFIRI+BV療法を6コース、XELOX+BV療法を13コース施行した。いずれのレジメンもprogressive disease(PD)となったため、fourth-lineとしてレゴラフェニブ療法を開始した。レゴラフェニブ開始前のレジメンにて手足症候群がみられたため、80mg/dayで開始した、Grade 2以上の副作用はでることなく投与開始後18ヵ月経過し、長期間partial response(PR)が持続し現在22コース施行中である。大腸癌肺転移再発症例に対してレゴラフェニブ投与により長期にわたるPRを得ることができた1例を経験した。(著者抄録)

  • Low Preoperative Prognostic Nutritional Index Predicts Poor Survival Post-gastrectomy in Elderly Patients with Gastric Cancer Reviewed

    Sakurai Katsunobu, Tamura Tatsuro, Toyokawa Takahiro, Amano Ryosuke, Kubo Naoshi, Tanaka Hiroaki, Muguruma Kazuya, Yashiro Masakazu, Maeda Kiyoshi, Ohira Masaichi, Hirakawa Kosei

    ANNALS OF SURGICAL ONCOLOGY   23 ( 11 )   3669 - 3676   2016.10( ISSN:1068-9265

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    DOI: 10.1245/s10434-016-5272-6

    PubMed

  • Low Preoperative Prognostic Nutritional Index Predicts Poor Survival Post-gastrectomy in Elderly Patients with Gastric Cancer Reviewed

    Katsunobu Sakurai, Tatsuro Tamura, Takahiro Toyokawa, Ryosuke Amano, Naoshi Kubo, Hiroaki Tanaka, Kazuya Muguruma, Masakazu Yashiro, Kiyoshi Maeda, Masaichi Ohira, Kosei Hirakawa

    ANNALS OF SURGICAL ONCOLOGY   23 ( 11 )   3669 - 3676   2016.10( ISSN:1068-9265 ( eISSN:1534-4681

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    Preoperative nutritional status may predict short- and long-term outcomes of patients with cancer.
    The aim of this study was to clarify the impact of preoperative nutritional status on outcomes of elderly patients who have undergone gastrectomy for gastric cancer (GC).
    A review examining 147 patients treated for GC by gastrectomy at our institution between January 2004 and December 2011 was conducted. Onodera's prognostic nutritional index (PNI) was invoked, using an optimal cutpoint to stratify patients by high (PNI &gt; 43.8; n = 84) or low (PNI aecurrency sign 43.8; n = 63) nutritional status. Clinicopathologic features and short- and long-term outcomes, including the cause of death, were compared.
    In multivariate analysis, low PNI was identified as an independent correlate of poor 5-year overall survival (OS). In subgroup analysis, 5-year OS rates for patients with stage 1 GC were significantly worse in the low PNI (vs. high PNI) patient subset, which also posed a significantly higher risk of death from other disease; however, 5-year cancer-specific survival and PNI were unrelated. Deaths from recurrence in both groups were statistically similar, and morbidity rates did not differ significantly by group.
    PNI is useful in predicting long-term outcomes of elderly patients surgically treated for GC, helping to identify those at high risk of death from other disease. In an effort to improve patient outcomes, nutritional status and oncologic staging merit attention.

    DOI: 10.1245/s10434-016-5272-6

    PubMed

  • The pretreatment Controlling Nutritional Status (CONUT) score is an independent prognostic factor in patients with resectable thoracic esophageal squamous cell carcinoma: results from a retrospective study Reviewed

    Toyokawa Takahiro, Kubo Naoshi, Tamura Tatsuro, Sakurai Katsunobu, Amano Ryosuke, Tanaka Hiroaki, Muguruma Kazuya, Yashiro Masakazu, Hirakawa Kosei, Ohira Masaichi

    BMC CANCER   16   722   2016.09( ISSN:1471-2407

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    DOI: 10.1186/s12885-016-2696-0

    PubMed

  • The pretreatment Controlling Nutritional Status (CONUT) score is an independent prognostic factor in patients with resectable thoracic esophageal squamous cell carcinoma: results from a retrospective study Reviewed

    Takahiro Toyokawa, Naoshi Kubo, Tatsuro Tamura, Katsunobu Sakurai, Ryosuke Amano, Hiroaki Tanaka, Kazuya Muguruma, Masakazu Yashiro, Kosei Hirakawa, Masaichi Ohira

    BMC CANCER   16 ( 1 )   722   2016.09( ISSN:1471-2407

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    Background: The purpose of this study was to investigate the impact of the Controlling Nutritional Status (CONUT) score on survival compared with the platelet to lymphocyte ratio (PLR), the neutrophil to lymphocyte ratio (NLR), and the Glasgow Prognostic Score (GPS) in patients with resectable thoracic esophageal squamous cell carcinoma (ESCC).
    Methods: One hundred eighty-five consecutive patients who underwent subtotal esophagectomy with curative intent for resectable thoracic ESCC were retrospectively reviewed. Time-dependent receiver operating characteristic curve analyses for 3-year overall survival (OS) as the endpoint were performed, and the maximal Youden indices were calculated to assess discrimination ability and to determine the appropriate cut-off values of CONUT, PLR, and NLR. The patients were then classified into high and low groups based on these cut-off values. Correlations between CONUT and other clinicopathological characteristics were analyzed. Prognostic factors predicting overall survival (OS) and relapse-free survival (RFS) were analyzed using Cox proportional hazards models.
    Results: The areas under the curve predicting 3-year OS were 0.603 for CONUT, 0.561 for PLR, 0.564 for NLR, and 0.563 for GPS. The optimal cut-off values were two for the CONUT score, 193 for PLR, and 3.612 for NLR. The high-CONUT group was significantly associated with lower BMI, high-PLR, high-NLR, and GPS1/2 groups. On univariate analysis, high-CONUT, high-PLR, high-NLR, and GPS 1/2 groups were significantly associated with poorer OS and RFS. Of these factors, multivariate analysis revealed that only the CONUT score was an independent prognostic factor for OS (HR 2.303, 95 % CI 1.191-4.455; p = 0.013) and RFS (HR 2.163, 95 % CI 1.139-4.109; p = 0.018).
    Conclusions: The CONUT score was an independent predictor of OS and RFS before treatment and was superior to PLR, NLR, and GPS in terms of predictive ability for prognosis in patients with resectable thoracic ESCC.

    DOI: 10.1186/s12885-016-2696-0

    PubMed

  • Pancreatic Fibroblasts Stimulate the Motility of Pancreatic Cancer Cells through IGF1/IGF1R Signaling under Hypoxia Reviewed

    Hirakawa Toshiki, Yashiro Masakazu, Doi Yosuke, Kinoshita Haruhito, Morisaki Tamami, Fukuoka Tatsunari, Hasegawa Tsuyoshi, Kimura Kenjiro, Amano Ryosuke, Hirakawa Kosei

    PLOS ONE   11 ( 8 )   e0159912   2016.08( ISSN:1932-6203

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    DOI: 10.1371/journal.pone.0159912

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  • Protection of stromal cell-derived factor 2 by heat shock protein 72 prevents oxaliplatin-induced cell death in oxaliplatin-resistant human gastric cancer cells Reviewed

    Takahashi Katsuyuki, Tanaka Masako, Yashiro Masakazu, Matsumoto Masaki, Ohtsuka Asuka, Nakayama Keiichi I., Izumi Yasukatsu, Nagayama Katsuya, Miura Katsuyuki, Iwao Hiroshi, Shiota Masayuki

    CANCER LETTERS   378 ( 1 )   8 - 15   2016.08( ISSN:0304-3835

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    DOI: 10.1016/j.canlet.2016.05.002

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  • Protection of stromal cell-derived factor 2 by heat shock protein 72 prevents oxaliplatin-induced cell death in oxaliplatin-resistant human gastric cancer cells Reviewed

    Katsuyuki Takahashi, Masako Tanaka, Masakazu Yashiro, Masaki Matsumoto, Asuka Ohtsuka, Keiichi I. Nakayama, Yasukatsu Izumi, Katsuya Nagayama, Katsuyuki Miura, Hiroshi Iwao, Masayuki Shiota

    CANCER LETTERS   378 ( 1 )   8 - 15   2016.08( ISSN:0304-3835 ( eISSN:1872-7980

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    Heat shock protein 72 (Hsp72) is a molecular chaperone that assists in the folding of nascent polypeptides and in the refolding of denatured proteins. In many cancers, Hsp72 is constitutively expressed at elevated levels, which can result in enhanced stress tolerance. Similarly, following treatment with anticancer drugs, Hsp72 binds to denatured proteins that may be essential for survival. We therefore hypothesized that Hsp72 client proteins may play a crucial role in drug resistance. Here, we aimed to identify proteins that are critical for oxaliplatin (OXA) resistance by analyzing human gastric cancer cell lines, as well as OXA-resistant cells via a mass spectrometry-based proteomic approach combined with affinity purification using anti-Hsp72 antibodies. Stromal cell-derived factor 2 (SDF-2) was identified as an Hsp72 client protein unique to OCUM-2M/OXA cells. SDF-2 was overexpressed in OXA-resistant cells and SDF-2 silencing promoted the apoptotic effects of OXA. Furthermore, Hsp72 prevented SDF-2 degradation in a chaperone activity-dependent manner. Together, our data demonstrate that Hsp72 protected SDF-2 to avoid OXA-induced cell death. We propose that inhibition of SDF-2 may comprise a novel therapeutic strategy to counteract OXA-resistant cancers. (C) 2016 Elsevier Ireland Ltd. All rights reserved.

    DOI: 10.1016/j.canlet.2016.05.002

    PubMed

  • Tumor-associated macrophages induce capillary morphogenesis of lymphatic endothelial cells derived from human gastric cancer Reviewed

    Tauchi Yukie, Tanaka Hiroaki, Kumamoto Kanako, Tokumoto Mao, Sakimura Chie, Sakurai Katsunobu, Kimura Kenjiro, Toyokawa Takahiro, Amano Ryosuke, Kubo Naoshi, Muguruma Kazuya, Yashiro Masakazu, Maeda Kiyoshi, Ohira Masaichi, Hirakawa Kosei

    CANCER SCIENCE   107 ( 8 )   1101 - 1109   2016.08( ISSN:1347-9032

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    DOI: 10.1111/cas.12977

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  • 腫瘍関連マクロファージはヒト胃癌由来リンパ管内皮細胞の毛細管形成を誘導する(Tumor-associated macrophages induce capillary morphogenesis of lymphatic endothelial cells derived from human gastric cancer) Reviewed

    Tauchi Yukie, Tanaka Hiroaki, Kumamoto Kanako, Tokumoto Mao, Sakimura Chie, Sakurai Katsunobu, Kimura Kenjiro, Toyokawa Takahiro, Amano Ryosuke, Kubo Naoshi, Muguruma Kazuya, Yashiro Masakazu, Maeda Kiyoshi, Ohira Masaichi, Hirakawa Kosei

    John Wiley & Sons Australia, Ltd Cancer Science   107 ( 8 )   1101 - 1109   2016.08( ISSN:1347-9032

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    胃癌の予後指標である腫瘍リンパ管形成におけるマクロファージの役割について検討するため、当院で胃癌の外科的処置が施行された患者の転移リンパ節(LN)由来リンパ管内皮細胞(LEC)と腫瘍関連マクロファージ間の相互作用について評価した。LECをマクロファージと直接的または間接的に、胃癌細胞系OCUM-12の培養上清の有無の条件下で共培養を行い、LECにおよぼすマクロファージの影響を解析し、共培養したLECの形態学的変化およびマクロファージとLECのリンパ管形成遺伝子発現について検討した。その結果、LECの管形成は接触培養時にのみ観察され、OCUM-12はマクロファージ誘導性の管形成を促進した。また、毛細管形成中のLECおよび共培養マクロファージの双方で、MMPと接着分子の遺伝子発現が有意にアップレギュレートされ、癌で前処理されたマクロファージにおいて、炎症性サイトカイン、MMP、接着分子、VEGF-Cなどのリンパ管形成因子のアップレギュレーションが示され、ICAM-1とマクロファージ活性化を阻害するとLECの管形成が抑制され、免疫組織化学から、リンパ管周囲に局在するマクロファージが検出された。以上の所見から、LECとマクロファージ間の相互作用が、LN転移を発症する腫瘍リンパ管形成の初期段階で重要なことが示唆された。

  • Tumor-associated macrophages induce capillary morphogenesis of lymphatic endothelial cells derived from human gastric cancer Reviewed

    Yukie Tauchi, Hiroaki Tanaka, Kanako Kumamoto, Mao Tokumoto, Chie Sakimura, Katsunobu Sakurai, Kenjiro Kimura, Takahiro Toyokawa, Ryosuke Amano, Naoshi Kubo, Kazuya Muguruma, Masakazu Yashiro, Kiyoshi Maeda, Masaichi Ohira, Kosei Hirakawa

    CANCER SCIENCE   107 ( 8 )   1101 - 9   2016.08( ISSN:1347-9032 ( eISSN:1349-7006

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    Tumor lymphangiogenesis is a major prognostic indicator of gastric cancer. Tumor-induced inflammation has been shown to attract tumor-associated macrophages that affect lymphangiogenesis. However, detailed mechanisms of macrophage-induced lymphangiogenesis have not been elucidated. Here, we evaluated the interaction between tumor-associated macrophages and lymphatic endothelial cells (LECs) derived from lymph nodes (LNs) of human gastric cancer. Lymphatic endothelial cells were directly or indirectly cocultured with macrophages from healthy human blood, with or without the supernatant of the gastric cancer cell line, OCUM-12. We analyzed the effect of cancer pretreated macrophages and of macrophages from metastatic LNs of gastric cancer on LECs. We observed morphological changes of LECs in coculture and assessed the gene expression of possible lymphangiogenic molecules of macrophages and LECs after contact coculture, and of cancer pretreated macrophages, by quantitative RT-PCR. Specimens of metastatic LN of gastric cancer were immunofluorescently stained. We found that tubulogenesis of LECs was observed only in the contact coculture model. OCUM-12 cells promoted macrophage-induced tubulogenesis of LECs. Relative gene expression of MMP and adhesion molecules was significantly upregulated in both capillary-forming LECs and cocultured macrophages. Cancer pretreated macrophages upregulated lymphangiogenic factors including inflammatory cytokines, MMPs, adhesion molecules, and vascular endothelial growth factor-C. Blocking of intercellular adhesion molecule-1 and macrophage activation suppressed tubulogenesis of LECs. Immunohistochemistry showed macrophages localized around lymphatic vessels. Our results suggested that interaction between LECs and macrophages may be an important initial step of tumor lymphangiogenesis developing LN metastasis. Understanding of its mechanisms could be useful for future therapeutics of gastric cancer.

    DOI: 10.1111/cas.12977

    PubMed

  • 腫瘍関連マクロファージはヒト胃癌由来リンパ管内皮細胞の毛細管形成を誘導する(Tumor-associated macrophages induce capillary morphogenesis of lymphatic endothelial cells derived from human gastric cancer) Reviewed

    Tauchi Yukie, Tanaka Hiroaki, Kumamoto Kanako, Tokumoto Mao, Sakimura Chie, Sakurai Katsunobu, Kimura Kenjiro, Toyokawa Takahiro, Amano Ryosuke, Kubo Naoshi, Muguruma Kazuya, Yashiro Masakazu, Maeda Kiyoshi, Ohira Masaichi, Hirakawa Kosei

    Cancer Science   107 ( 8 )   1101 - 1109   2016.08( ISSN:1347-9032

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    胃癌の予後指標である腫瘍リンパ管形成におけるマクロファージの役割について検討するため、当院で胃癌の外科的処置が施行された患者の転移リンパ節(LN)由来リンパ管内皮細胞(LEC)と腫瘍関連マクロファージ間の相互作用について評価した。LECをマクロファージと直接的または間接的に、胃癌細胞系OCUM-12の培養上清の有無の条件下で共培養を行い、LECにおよぼすマクロファージの影響を解析し、共培養したLECの形態学的変化およびマクロファージとLECのリンパ管形成遺伝子発現について検討した。その結果、LECの管形成は接触培養時にのみ観察され、OCUM-12はマクロファージ誘導性の管形成を促進した。また、毛細管形成中のLECおよび共培養マクロファージの双方で、MMPと接着分子の遺伝子発現が有意にアップレギュレートされ、癌で前処理されたマクロファージにおいて、炎症性サイトカイン、MMP、接着分子、VEGF-Cなどのリンパ管形成因子のアップレギュレーションが示され、ICAM-1とマクロファージ活性化を阻害するとLECの管形成が抑制され、免疫組織化学から、リンパ管周囲に局在するマクロファージが検出された。以上の所見から、LECとマクロファージ間の相互作用が、LN転移を発症する腫瘍リンパ管形成の初期段階で重要なことが示唆された。

  • Identification of anti-cancer chemical compounds using Xenopus embryos Reviewed

    Tanaka Masamitsu, Kuriyama Sei, Itoh Go, Kohyama Aki, Iwabuchi Yoshiharu, Shibata Hiroyuki, Yashiro Masakazu, Aiba Namiko

    CANCER SCIENCE   107 ( 6 )   803 - 811   2016.06( ISSN:1347-9032

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    DOI: 10.1111/cas.12940

    PubMed

  • Xenopus胚を用いた抗癌化合物の同定(Identification of anti-cancer chemical compounds using Xenopus embryos) Reviewed

    Tanaka Masamitsu, Kuriyama Sei, Itoh Go, Kohyama Aki, Iwabuchi Yoshiharu, Shibata Hiroyuki, Yashiro Masakazu, Aiba Namiko

    John Wiley & Sons Australia, Ltd Cancer Science   107 ( 6 )   803 - 811   2016.06( ISSN:1347-9032

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    Xenopus胚の原腸形成または頭部神経冠細胞(CNCC)移動の阻害を指標として、癌浸潤を抑制する抗癌化合物をスクリーニングする手法について検討した。原腸形成に及ぼす効果は、ステージ10(原腸形成開始時)に達した胚を化合物で処理し、対照胚のステージ12 1/2およびステージ14到達時に原口閉鎖の状態を評価した。また、CNCCに及ぼす効果は、原腸形成後の胚を化合物で処理し、ホールマウントin situハイブリダイゼーションによりCNCCの移動の評価を行った。その結果、AMD3100およびパクリタキセルは、原口閉鎖を阻害し、CNCC移動に影響を及ぼした。さらに、100の合成化合物を盲検的にスクリーニングし、胚致死性を示さず、原腸形成または神経冠発生に重篤な欠損を認めた9つの化合物を候補化合物としたところ、候補化合物中、ポドフィロトキシンアナログであるC-157およびインドールアルカロイドであるD-572は、間期微小管の破壊を通して癌細胞浸潤を阻害し、SAS細胞のアポトーシスを誘導し、マウスに異種移植された腫瘍増殖および浸潤を抑制した。以上の所見から、Xenopus胚は、腫瘍増殖および浸潤に影響を及ぼす化合物のスクリーニングに有用と考えられた。

  • Identification of anti-cancer chemical compounds using Xenopus embryos Reviewed

    Masamitsu Tanaka, Sei Kuriyama, Go Itoh, Aki Kohyama, Yoshiharu Iwabuchi, Hiroyuki Shibata, Masakazu Yashiro, Namiko Aiba

    CANCER SCIENCE   107 ( 6 )   803 - 11   2016.06( ISSN:1347-9032 ( eISSN:1349-7006

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    Cancer tissues have biological characteristics similar to those observed in embryos during development. Many types of cancer cells acquire pro-invasive ability through epithelial-mesenchymal transition (EMT). Similar processes (gastrulation and migration of cranial neural crest cells [CNCC]) are observed in the early stages of embryonic development in Xenopus during which cells that originate from epithelial sheets through EMT migrate to their final destinations. The present study examined Xenopus embryonic tissues to identify anti-cancer compounds that prevent cancer invasion. From the initial test of known anti-cancer drugs, AMD3100 (an inhibitor of CXCR4) and paclitaxel (a cytoskeletal drug targeting microtubules) effectively prevented migration during gastrulation or CNCC development. Blind-screening of 100 synthesized chemical compounds was performed, and nine candidates that inhibited migration of these embryonic tissues without embryonic lethality were selected. Of these, C-157 (an analog of podophyllotoxin) and D-572 (which is an indole alkaroid) prevented cancer cell invasion through disruption of interphase microtubules. In addition, these compounds affected progression of mitotic phase and induced apoptosis of SAS oral cancer cells. SAS tumors were reduced in size after intratumoral injection of C-157, and peritoneal dissemination of melanoma cells and intracranial invasion of glioma cells were inhibited by C-157 and D-572. When the other analogues of these chemicals were compared, those with subtle effect on embryos were not tumor suppressive. These results suggest that a novel chemical-screening approach based on Xenopus embryos is an effective method for isolating anti-cancer drugs and, in particular, targeting cancer cell invasion and proliferation.

    DOI: 10.1111/cas.12940

    PubMed

  • Xenopus胚を用いた抗癌化合物の同定(Identification of anti-cancer chemical compounds using Xenopus embryos) Reviewed

    Tanaka Masamitsu, Kuriyama Sei, Itoh Go, Kohyama Aki, Iwabuchi Yoshiharu, Shibata Hiroyuki, Yashiro Masakazu, Aiba Namiko

    Cancer Science   107 ( 6 )   803 - 811   2016.06( ISSN:1347-9032

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    Xenopus胚の原腸形成または頭部神経冠細胞(CNCC)移動の阻害を指標として、癌浸潤を抑制する抗癌化合物をスクリーニングする手法について検討した。原腸形成に及ぼす効果は、ステージ10(原腸形成開始時)に達した胚を化合物で処理し、対照胚のステージ12 1/2およびステージ14到達時に原口閉鎖の状態を評価した。また、CNCCに及ぼす効果は、原腸形成後の胚を化合物で処理し、ホールマウントin situハイブリダイゼーションによりCNCCの移動の評価を行った。その結果、AMD3100およびパクリタキセルは、原口閉鎖を阻害し、CNCC移動に影響を及ぼした。さらに、100の合成化合物を盲検的にスクリーニングし、胚致死性を示さず、原腸形成または神経冠発生に重篤な欠損を認めた9つの化合物を候補化合物としたところ、候補化合物中、ポドフィロトキシンアナログであるC-157およびインドールアルカロイドであるD-572は、間期微小管の破壊を通して癌細胞浸潤を阻害し、SAS細胞のアポトーシスを誘導し、マウスに異種移植された腫瘍増殖および浸潤を抑制した。以上の所見から、Xenopus胚は、腫瘍増殖および浸潤に影響を及ぼす化合物のスクリーニングに有用と考えられた。

  • Orthotopic Implantation of Intact Tumor Tissue Leads to Metastasis of OCUM-2MD3 Human Gastric Cancer in Nude Mice Visualized in Real Time by Intravital Fluorescence Imaging Reviewed

    Murakami Takashi, Zhang Yong, Wang Xiaoen, Hiroshima Yukihiko, Kasashima Hiroaki, Yashiro Masakazu, Hirakawa Kosei, Miwa Atsushi, Kiyuna Tasuku, Matsuyama Ryusei, Tanaka Kuniya, Bouvet Michael, Endo Itaru, Hoffman Robert M.

    ANTICANCER RESEARCH   36 ( 5 )   2125 - 2130   2016.05( ISSN:0250-7005

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  • Orthotopic Implantation of Intact Tumor Tissue Leads to Metastasis of OCUM-2MD3 Human Gastric Cancer in Nude Mice Visualized in Real Time by Intravital Fluorescence Imaging. Reviewed

    Murakami T, Zhang Y, Wang X, Hiroshima Y, Kasashima H, Yashiro M, Hirakawa K, Miwa A, Kiyuna T, Matsuyama R, Tanaka K, Bouvet M, Endo I, Hoffman RM

    Anticancer research   36 ( 5 )   2125 - 30   2016.05( ISSN:0250-7005

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    PubMed

  • Orthotopic Implantation of Intact Tumor Tissue Leads to Metastasis of OCUM-2MD3 Human Gastric Cancer in Nude Mice Visualized in Real Time by Intravital Fluorescence Imaging Reviewed

    Takashi Murakami, Yong Zhang, Xiaoen Wang, Yukihiko Hiroshima, Hiroaki Kasashima, Masakazu Yashiro, Kosei Hirakawa, Atsushi Miwa, Tasuku Kiyuna, Ryusei Matsuyama, Kuniya Tanaka, Michael Bouvet, Itaru Endo, Robert M. Hoffman

    ANTICANCER RESEARCH   36 ( 5 )   2125 - 2130   2016.05( ISSN:0250-7005 ( eISSN:1791-7530

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    Background/Aim: Orthotopic (literally "correct place") implantation of cancer in nude mice has long been known to be superior to subcutaneous transplantation because the orthotopic tumor can metastasize. We reported previously on surgical orthotopic implantation (SOI) of gastric cancer tissue in nude mice resulting in the formation of metastases in 100% of the mice with extensive primary growth to the regional lymph nodes, liver, and lung. In contrast, when cell suspensions were used to inject gastric cancer cells orthotopically, metastases occurred in only 6.7% of the mice with local tumor formation, emphasizing the importance of orthotopically implanting intact tissue to allow full expression of metastatic potential. However, the different behavior of tumors implanted orthotopically by the two methods has not been visualized in real time. Materials and Methods: OCUM-2MD3 human gastric cancer cells labeled with the fluorescent protein Azami-Green were implanted orthotopically as cells or tissue in nude mice. Results: Orthotopic implantation of cells resulted in local spread on the stomach. In contrast, SOI of tumor tissue of OCUM-2MD3 resulted in vessel spread of the Azami-Green-expressing cancer cells. Metastasis was also observed in the left lobe of the liver after SOI. Conclusion: These results demonstrate the physiological importance of intact cancer tissue for orthotopic implantation in order for tumors to properly grow and express their metastatic potential.

    PubMed

  • Orthotopic Implantation of Intact Tumor Tissue Leads to Metastasis of OCUM-2MD3 Human Gastric Cancer in Nude Mice Visualized in Real Time by Intravital Fluorescence Imaging. Reviewed

    Murakami T, Zhang Y, Wang X, Hiroshima Y, Kasashima H, Yashiro M, Hirakawa K, Miwa A, Kiyuna T, Matsuyama R, Tanaka K, Bouvet M, Endo I, Hoffman RM

    Anticancer research   36 ( 5 )   2125 - 30   2016.05( ISSN:0250-7005

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    PubMed

  • Establishment and characterization of new cell lines of anaplastic pancreatic cancer, which is a rare malignancy: OCUP-A1 and OCUP-A2 Reviewed

    Miura Kotaro, Kimura Kenjiro, Amano Ryosuke, Yamazoe Sadaaki, Ohira Go, Murata Akihiro, Nishio Kohei, Hasegawa Tsuyoshi, Yashiro Masakazu, Nakata Bunzo, Ohira Masaichi, Hirakawa Kosei

    BMC CANCER   16   268   2016.04( ISSN:1471-2407

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    DOI: 10.1186/s12885-016-2297-y

    PubMed

  • Establishment and characterization of new cell lines of anaplastic pancreatic cancer, which is a rare malignancy: OCUP-A1 and OCUP-A2 Reviewed

    Kotaro Miura, Kenjiro Kimura, Ryosuke Amano, Sadaaki Yamazoe, Go Ohira, Akihiro Murata, Kohei Nishio, Tsuyoshi Hasegawa, Masakazu Yashiro, Bunzo Nakata, Masaichi Ohira, Kosei Hirakawa

    BMC CANCER   16   268   2016.04( ISSN:1471-2407

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    Background: Anaplastic pancreatic cancer (APC) cell lines have been scarcely established.
    Methods: The morphology, gene expressions, karyotyping and epithelial-mesenchymal transition markers of newly established APC cell lines OCUP-A1 and OCUP-A2 were analyzed. Their abilities of proliferation under normoxia and hypoxia, migration and invasion were compared to 4 commercially available pancreatic ductal adenocarcinoma (PDA) cell lines. Their induction of angiogenesis, stem-like cell population and subcutaneous tumor growth in nude mice were estimated, comparing 2 PDA cell lines examined here.
    Results: OCUP-A1 and OCUP-A2 cells continuously grew with spindle and polygonal shapes, respectively. Gene analysis revealed 9 gene mutations including KRAS and TP53. Karyotyping clarified numerical structural abnormalities in both cells. Loss of E-cadherin and expression of vimentin in both cell lines were observed. The doubling time of both cell lines was approximately 20 h. Proliferation, migration and invasion abilities were not notable compared to other PDA cell lines. However stem-like cell population of both cell lines was superior to a part of PDA cell lines. Moreover OCUP-A1 showed stronger hypoxia tolerance and induction of angiogenesis than other PDA cell lines. The tumorigenicity in vivo of OCUP-A2 was stronger than conventional PDA cell lines.
    Conclusions: The OCUP-A1 and OCUP-A2 cell lines of rare malignancies might be useful for investigating the biology of pancreatic cancer.

    DOI: 10.1186/s12885-016-2297-y

    PubMed

  • Lysyl oxidase is associated with the epithelial-mesenchymal transition of gastric cancer cells in hypoxia Reviewed

    Kasashima Hiroaki, Yashiro Masakazu, Kinoshita Haruhito, Fukuoka Tatsunari, Morisaki Tamami, Masuda Go, Sakurai Katsunobu, Kubo Naoshi, Ohira Masaichi, Hirakawa Kosei

    GASTRIC CANCER   19 ( 2 )   431 - 442   2016.04( ISSN:1436-3291

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    DOI: 10.1007/s10120-015-0510-3

    PubMed

  • Lysyl oxidaseは低酸素状態における胃癌細胞の上皮間葉移行に関連している(Lysyl oxidase is associated with the epithelial-mesenchymal transition of gastric cancer cells in hypoxia) Reviewed

    Kasashima Hiroaki, Yashiro Masakazu, Kinoshita Haruhito, Fukuoka Tatsunari, Morisaki Tamami, Masuda Go, Sakurai Katsunobu, Kubo Naoshi, Ohira Masaichi, Hirakawa Kosei

    シュプリンガー・ジャパン(株) Gastric Cancer   19 ( 2 )   431 - 442   2016.04( ISSN:1436-3291

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    低酸素状態の胃癌細胞における上皮間葉移行(EMT)とlysyl oxidase(LOX)の関係を検討した。2種類の胃癌細胞株(OCUM-2MD3とOCUM-12)をin vitro試験に用いた。LOXの低分子干渉RNA(siRNA)がEMTに及ぼす影響、および低酸素状態での癌細胞の運動性を、逆転写PCR法、ウェスタンブロット法、創傷治癒アッセイ法および細胞浸潤アッセイ法により解析した。544例の胃癌患者におけるLOX発現と臨床病理学的特性との相関性を免疫組織化学法により検討した。低酸素状態によって、胃癌細胞のEMTに起因する多角細胞または紡錘状細胞が増加した。低酸素状態によって誘発された癌細胞のEMTは、LOXのsiRNA処理により抑制された。低酸素状態で遊走および浸潤する胃癌細胞数は、LOXノックダウンにより有意に減少した。LOXのsiRNAは、胃癌細胞のE-cadherin濃度を有意に増加させ、vimentin濃度を有意に低下させた。LOX発現は、深達度、腫瘍分化度、リンパ節転移、リンパ浸潤、血管浸潤および腹膜転移と有意に関係していた。多変量解析の結果、LOXは、全生存期間の独立したパラメータであった。

  • Lysyl oxidase is associated with the epithelial-mesenchymal transition of gastric cancer cells in hypoxia Reviewed

    Hiroaki Kasashima, Masakazu Yashiro, Haruhito Kinoshita, Tatsunari Fukuoka, Tamami Morisaki, Go Masuda, Katsunobu Sakurai, Naoshi Kubo, Masaichi Ohira, Kosei Hirakawa

    GASTRIC CANCER   19 ( 2 )   431 - 442   2016.04( ISSN:1436-3291 ( eISSN:1436-3305

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    It has been reported that lysyl oxidase (LOX) is a hypoxia-responsive factor and is associated with the malignant progression of carcinoma. The aim of this study was to clarify the relationship between the epithelial-mesenchymal transition (EMT) and LOX in gastric cancer cells under hypoxia.
    Two gastric cancer cell lines, OCUM-2MD3 and OCUM-12, were used in an in vitro study. The effect of LOX small interfering RNA (siRNA) on the EMT and motility of gastric cancer cells under hypoxic condition was analyzed by reverse transcription PCR, Western blot, a wound-healing assay, and an invasion assay. Correlations between LOX expression and the clinicopathological features of 544 patients with gastric carcinoma were examined immunohistochemically.
    Hypoxic conditions increased the number of polygonal or spindle-shaped cells resulting from EMT in gastric cancer cells. The EMT of cancer cells induced by hypoxia was inhibited by treatment with LOX siRNA. The number of migrating and invading gastric cancer cells in hypoxia was significantly decreased by LOX knockdown. LOX siRNA significantly increased the E-cadherin level and decreased the vimentin level of gastric cancer cells. LOX expression was significantly associated with invasion depth, tumor differentiation, lymph node metastasis, lymphatic invasion, venous invasion, and peritoneal metastasis. Multivariable analysis revealed that LOX was an independent parameter for overall survival.
    LOX affects the EMT of gastric cancer cells in hypoxic conditions. LOX expression is a useful prognostic factor for patients with gastric cancer.

    DOI: 10.1007/s10120-015-0510-3

    PubMed

  • Lysyl oxidaseは低酸素状態における胃癌細胞の上皮間葉移行に関連している(Lysyl oxidase is associated with the epithelial-mesenchymal transition of gastric cancer cells in hypoxia) Reviewed

    Kasashima Hiroaki, Yashiro Masakazu, Kinoshita Haruhito, Fukuoka Tatsunari, Morisaki Tamami, Masuda Go, Sakurai Katsunobu, Kubo Naoshi, Ohira Masaichi, Hirakawa Kosei

    Gastric Cancer   19 ( 2 )   431 - 442   2016.04( ISSN:1436-3291

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    Publishing type:Research paper (scientific journal)  

    低酸素状態の胃癌細胞における上皮間葉移行(EMT)とlysyl oxidase(LOX)の関係を検討した。2種類の胃癌細胞株(OCUM-2MD3とOCUM-12)をin vitro試験に用いた。LOXの低分子干渉RNA(siRNA)がEMTに及ぼす影響、および低酸素状態での癌細胞の運動性を、逆転写PCR法、ウェスタンブロット法、創傷治癒アッセイ法および細胞浸潤アッセイ法により解析した。544例の胃癌患者におけるLOX発現と臨床病理学的特性との相関性を免疫組織化学法により検討した。低酸素状態によって、胃癌細胞のEMTに起因する多角細胞または紡錘状細胞が増加した。低酸素状態によって誘発された癌細胞のEMTは、LOXのsiRNA処理により抑制された。低酸素状態で遊走および浸潤する胃癌細胞数は、LOXノックダウンにより有意に減少した。LOXのsiRNAは、胃癌細胞のE-cadherin濃度を有意に増加させ、vimentin濃度を有意に低下させた。LOX発現は、深達度、腫瘍分化度、リンパ節転移、リンパ浸潤、血管浸潤および腹膜転移と有意に関係していた。多変量解析の結果、LOXは、全生存期間の独立したパラメータであった。

  • Current status in remnant gastric cancer after distal gastrectomy Reviewed

    Ohira Masaichi, Toyokawa Takahiro, Sakurai Katsunobu, Kubo Naoshi, Tanaka Hiroaki, Muguruma Kazuya, Yashiro Masakazu, Onoda Naoyoshi, Hirakawa Kosei

    WORLD JOURNAL OF GASTROENTEROLOGY   22 ( 8 )   2424 - 2433   2016.02( ISSN:1007-9327

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    DOI: 10.3748/wjg.v22.i8.2424

    PubMed

  • Fibroblast growth factor receptor signaling as therapeutic targets in gastric cancer Reviewed

    Yashiro Masakazu, Matsuoka Tasuku

    WORLD JOURNAL OF GASTROENTEROLOGY   22 ( 8 )   2415 - 2423   2016.02( ISSN:1007-9327

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    DOI: 10.3748/wjg.v22.i8.2415

    PubMed

  • Fibroblast growth factor receptor signaling as therapeutic targets in gastric cancer Reviewed

    Masakazu Yashiro, Tasuku Matsuoka

    WORLD JOURNAL OF GASTROENTEROLOGY   22 ( 8 )   2415 - 23   2016.02( ISSN:1007-9327 ( eISSN:2219-2840

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    Fibroblast growth factor receptors (FGFRs) regulate a variety of cellular functions, from embryogenesis to adult tissue homeostasis. FGFR signaling also plays significant roles in the proliferation, invasion, and survival of several types of tumor cells. FGFR-induced alterations, including gene amplification, chromosomal translocation, and mutations, have been shown to be associated with the tumor initiation and progression of gastric cancer, especially in diffuse-type cancers. Therefore, the FGFR signaling pathway might be one of the therapeutic targets in gastric cancer. This review aims to provide an overview of the role of FGFR signaling in tumorigenesis, tumor progression, proliferation, and chemoresistance. We also discuss the accumulating evidence that demonstrates the effectiveness of using clinical therapeutic agents to inhibit FGFR signaling for the treatment of gastric cancer.

    DOI: 10.3748/wjg.v22.i8.2415

    PubMed

  • Current status in remnant gastric cancer after distal gastrectomy Reviewed

    Masaichi Ohira, Takahiro Toyokawa, Katsunobu Sakurai, Naoshi Kubo, Hiroaki Tanaka, Kazuya Muguruma, Masakazu Yashiro, Naoyoshi Onoda, Kosei Hirakawa

    WORLD JOURNAL OF GASTROENTEROLOGY   22 ( 8 )   2424 - 33   2016.02( ISSN:1007-9327 ( eISSN:2219-2840

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    Remnant gastric cancer (RGC) and gastric stump cancer after distal gastrectomy (DG) are recognized as the same clinical entity. In this review, the current knowledges as well as the non-settled issues of RGC are presented. Duodenogastric reflux and denervation of the gastric mucosa are considered as the two main factors responsible for the development of RGC after benign disease. On the other hand, some precancerous circumstances which already have existed at the time of initial surgery, such as atrophic gastritis and intestinal metaplasia, are the main factors associated with RGC after gastric cancer. Although eradication of Helicobacter pylori (H. pylori) in remnant stomach is promising, it is still uncertain whether it can reduce the risk of carcinogenesis. Periodic endoscopic surveillance after DG was reported useful in detecting RGC at an early stage, which offers a chance to undergo minimally invasive endoscopic treatment or laparoscopic surgery and leads to an improved prognosis in RGC patients. Future challenges may be expected to elucidate the benefit of eradication of H. pylori in the remnant stomach if it could reduce the risk for RGC, to build an optimal endoscopic surveillance strategy after DG by stratifying the risk for development of RGC, and to develop a specific staging system for RGC for the standardization of the treatment by prospecting the prognosis.

    DOI: 10.3748/wjg.v22.i8.2424

    PubMed

  • Predictive Potential of Preoperative Nutritional Status in Long-Term Outcome Projections for Patients with Gastric Cancer Reviewed

    Sakurai Katsunobu, Ohira Masaichi, Tamura Tatsuro, Toyokawa Takahiro, Amano Ryosuke, Kubo Naoshi, Tanaka Hiroaki, Muguruma Kazuya, Yashiro Masakazu, Maeda Kiyoshi, Hirakawa Kosei

    ANNALS OF SURGICAL ONCOLOGY   23 ( 2 )   525 - 533   2016.02( ISSN:1068-9265

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    DOI: 10.1245/s10434-015-4814-7

    PubMed

  • Predictive Potential of Preoperative Nutritional Status in Long-Term Outcome Projections for Patients with Gastric Cancer Reviewed

    Katsunobu Sakurai, Masaichi Ohira, Tatsuro Tamura, Takahiro Toyokawa, Ryosuke Amano, Naoshi Kubo, Hiroaki Tanaka, Kazuya Muguruma, Masakazu Yashiro, Kiyoshi Maeda, Kosei Hirakawa

    ANNALS OF SURGICAL ONCOLOGY   23 ( 2 )   525 - 33   2016.02( ISSN:1068-9265 ( eISSN:1534-4681

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    Preoperative nutritional status not only correlates with the incidence of postoperative complications but also may be indicative of long-term outcomes for patients with cancer. The impact of preoperative nutritional status on outcomes for patients undergoing gastrectomy for gastric cancer (GC) was investigated.
    The study reviewed 594 patients treated for GC by gastrectomy at the authors' hospital between January, 2004 and December, 2010. Onodera's prognostic nutritional index (PNI) was invoked, using an optimal cut point to group patients as having high (PNI &gt; 45; n = 449) or low (PNI a parts per thousand currency sign 45; n = 145) nutritional status. Clinicopathologic features, perioperative results, and long-term outcomes, including cause of death, were compared.
    Multivariate analysis of 5-year overall survival (OS) and disease-specific survival (DSS) indicated that low PNI was independently associated with unfavorable outcomes for patients with GC. In subgroup analysis, the 5-year OS and DSS rates for patients with GC at stages 1 and 2 were significantly worse in the low PNI group than in the high PNI group. Although wound and extrasurgical field infections also tended to be more frequent in the low PNI group, postoperative intraabdominal infections did not differ significantly by group.
    Preoperative PNI may have merit as a gauge of prognosis for patients with GC at stages 1 and 2, but PNI and postoperative morbidity showed no correlation in this setting.

    DOI: 10.1245/s10434-015-4814-7

    PubMed

  • Molecular targets for the treatment of pancreatic cancer: Clinical and experimental studies Reviewed

    Matsuoka Tasuku, Yashiro Masakazu

    WORLD JOURNAL OF GASTROENTEROLOGY   22 ( 2 )   776 - 789   2016.01( ISSN:1007-9327

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    DOI: 10.3748/wjg.v22.i2.776

    PubMed

  • Molecular targets for the treatment of pancreatic cancer: Clinical and experimental studies Reviewed

    Tasuku Matsuoka, Masakazu Yashiro

    WORLD JOURNAL OF GASTROENTEROLOGY   22 ( 2 )   776 - 89   2016.01( ISSN:1007-9327 ( eISSN:2219-2840

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    Pancreatic cancer is the fourth most common cause of cancer deaths worldwide. Although recent therapeutic developments for patients with pancreatic cancer have provided survival benefits, the outcomes for patients with pancreatic cancer remain unsatisfactory. Molecularly targeted cancer therapy has advanced in the past decade with the use of a number of pathways as candidates of therapeutic targets. This review summarizes the molecular features of this refractory disease while focusing on the recent clinical and experimental findings on pancreatic cancer. It also discusses the data supporting current standard clinical outcomes, and offers conclusions that may improve the management of pancreatic cancer in the future.

    DOI: 10.3748/wjg.v22.i2.776

    PubMed

  • Clinicopathological Correlations of Autophagy-related Proteins LC3, Beclin 1 and p62 in Gastric Cancer Reviewed

    Masuda Go, Yashiro Masakazu, Kitayama Kishu, Miki Yuichiro, Kasashima Hiroaki, Kinoshita Haruhito, Morisaki Tamami, Fukuoka Tatshunari, Hasegawa Tsuyoshi, Sakurai Katsunobu, Toyokawa Takahiro, Kubo Naoshi, Tanaka Hiroaki, Muguruma Kazuya, Masaichi Ohira, Hirakawa Kosei

    ANTICANCER RESEARCH   36 ( 1 )   129 - 136   2016.01( ISSN:0250-7005

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  • Clinicopathological Correlations of Autophagy-related Proteins LC3, Beclin 1 and p62 in Gastric Cancer. Reviewed

    Masuda GO, Yashiro M, Kitayama K, Miki Y, Kasashima H, Kinoshita H, Morisaki T, Fukuoka T, Hasegawa T, Sakurai K, Toyokawa T, Kubo N, Tanaka H, Muguruma K, Masaichi O, Hirakawa K

    Anticancer research   36 ( 1 )   129 - 36   2016.01( ISSN:0250-7005

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    PubMed

  • Clinicopathological Correlations of Autophagy-related Proteins LC3, Beclin 1 and p62 in Gastric Cancer Reviewed

    Go Masuda, Masakazu Yashiro, Kishu Kitayama, Yuichiro Miki, Hiroaki Kasashima, Haruhito Kinoshita, Tamami Morisaki, Tatshunari Fukuoka, Tsuyoshi Hasegawa, Katsunobu Sakurai, Takahiro Toyokawa, Naoshi Kubo, Hiroaki Tanaka, Kazuya Muguruma, Ohira Masaichi, Kosei Hirakawa

    ANTICANCER RESEARCH   36 ( 1 )   129 - 136   2016.01( ISSN:0250-7005 ( eISSN:1791-7530

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    Aim: This study evaluated the clinicopathological significance of autophagy, an intracellular degradation system, in gastric cancer. Materials and Methods: The expression levels of three autophagy-related proteins, namely light chain 3 (LC3), Beclin 1 and p62, were analyzed by immunohistochemistry using samples from 510 patients with primary gastric cancer. Results: LC3, Beclin 1, and p62 expression was positive in 79 (15.5%), 126 (24.7%) and 251 (49.2%) out of 510 carcinomas, respectively. Autophagy was defined when samples were positive for at least two out of the three proteins. Autophagy-positive cases were 113 (22.1%) out of the 510. Autophagy determined by LC3, Beclin 1, and p62 significantly correlated with lymph node metastasis, vessel invasion, and hepatic metastasis. A Kaplan-Meier survival curve showed that autophagy was significantly associated with poor survival of patients with gastric cancer, especially for those with disease at stage I. Multivariate analysis indicated that autophagy was an independent prognostic factor. Conclusion: Autophagy promotes the progression of gastric cancer at an early clinical stage.

    PubMed

  • Clinicopathological Correlations of Autophagy-related Proteins LC3, Beclin 1 and p62 in Gastric Cancer. Reviewed

    Masuda GO, Yashiro M, Kitayama K, Miki Y, Kasashima H, Kinoshita H, Morisaki T, Fukuoka T, Hasegawa T, Sakurai K, Toyokawa T, Kubo N, Tanaka H, Muguruma K, Masaichi O, Hirakawa K

    Anticancer research   36 ( 1 )   129 - 36   2016.01( ISSN:0250-7005

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    PubMed

  • Pancreatic Fibroblasts Stimulate the Motility of Pancreatic Cancer Cells through IGF1/IGF1R Signaling under Hypoxia Reviewed

    Toshiki Hirakawa, Masakazu Yashiro, Yosuke Doi, Haruhito Kinoshita, Tamami Morisaki, Tatsunari Fukuoka, Tsuyoshi Hasegawa, Kenjiro Kimura, Ryosuke Amano, Kosei Hirakawa

    PLOS ONE   11 ( 8 )   e0159912   2016( ISSN:1932-6203

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    Pancreatic ductal adenocarcinoma (PDAC) is characterized by its hypovascularity, with an extremely poor prognosis because of its highly invasive nature. PDAC proliferates with abundant stromal cells, suggesting that its invasive activity might be controlled by intercellular interactions between cancer cells and fibroblasts. Using four PDAC cell lines and two pancreas cancer-associated fibroblasts (CAFs), the expression of insulin-like growth factor-1 (IGF1) and IGF1 receptor (IGF1R) was evaluated by RT-PCR, FACScan, western blot, or ELISA. Correlation between IGF1R and the hypoxia marker carbonic anhydrase 9 (CA9) was examined by immunohistochemical staining of 120 pancreatic specimens. The effects of CAFs, IGF1, and IGF1R inhibitors on the motility of cancer cells were examined by wound-healing assay or invasion assay under normoxia (20% O-2) and hypoxia (1% O-2). IGF1R expression was significantly higher in RWP-1, MiaPaCa-2, and OCUP-AT cells than in Panc-1 cells. Hypoxia increased the expression level of IGF1R in RWP-1, MiaPaCa-2, and OCUP-AT cells. CA9 expression was correlated with IGF1R expression in pancreatic specimens. CAFs produced IGF1 under hypoxia, but PDAC cells did not. A conditioned medium from CAFs, which expressed alpha SMA, stimulated the migration and invasion ability of MiaPaCa-2, RWP-1, and OCUP-AT cells. The motility of all PDAC cells was greater under hypoxia than under normoxia. The motility-stimulating ability of CAFs was decreased by IGF1R inhibitors. These findings might suggest that pancreas CAFs stimulate the invasion activity of PDAC cells through paracrine IGF1/IGF1R signaling, especially under hypoxia. Therefore the targeting of IGF1R signaling might represent a promising therapeutic approach in IGF1R-dependent PDAC.

    DOI: 10.1371/journal.pone.0159912

    PubMed

  • 4ヵ月のプレドニゾロン療法とポリープ切除術により完全寛解したCronkhite-Canada症候群(Cronkhite-Canada Syndrome with Complete Remission after Four Months of Prednisolone Therapy and Polypectomy) Reviewed

    Namikawa Hiroki, Takemoto Yasuhiko, Kamata Noriko, Yashiro Masakazu, Hirohashi Kazuhiro, Shuto Taichi

    (一社)日本プライマリ・ケア連合学会 Journal of General and Family Medicine   16 ( 4 )   297 - 301   2015.12( ISSN:2189-6577

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    66歳男。脱毛症、味覚異常および下痢のため受診した。全身性脱毛、爪異栄養症、皮膚色素沈着および両下肢浮腫がみられ、リウマチ因子、メタロプロテアーゼ3および抗CCP抗体の上昇から自己免疫疾患が疑われた。上部消化管内視鏡および大腸鏡検査にて胃、十二指腸および結腸にポリープが観察された。以上の所見はCronkhite-Canada症候群(CCS)に一致した。生検にて胃ポリープに過形成、結腸ポリープに過形成および腺腫がみられた。CCSの診断後速やかに経口プレドニゾロン療法を開始し、症状の著明な改善を得た。4ヵ月間のプレドニゾロン漸減投与により上部消化管ポリープは消失し、残存していた4個の結腸ポリープは切除された。結腸ポリープの1つに粘膜内腺癌が発見されたが、断端に悪性所見はなく、CCSの完全寛解が確認された。プレドニゾロン療法中止から9ヵ月現在、再発はみられなかった。

  • Cronkhite-Canada Syndrome with Complete Remission after Four Months of Prednisolone Therapy and Polypectomy Reviewed

    Namikawa Hiroki, Takemoto Yasuhiko, Kamata Noriko, Yashiro Masakazu, Hirohashi Kazuhiro, Shuto Taichi

    JOURNAL OF GENERAL AND FAMILY MEDICINE   16 ( 4 )   297 - 301   2015.12( ISSN:2189-7948

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  • Transforming somatic mutations of mammalian target of rapamycin kinase in human cancer Reviewed

    Yamaguchi Hiroyuki, Kawazu Masahito, Yasuda Takahiko, Soda Manabu, Ueno Toshihide, Kojima Shinya, Yashiro Masakazu, Yoshino Ichiro, Ishikawa Yuichi, Sai Eirin, Mano Hiroyuki

    CANCER SCIENCE   106 ( 12 )   1687 - 1692   2015.12( ISSN:1347-9032

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    DOI: 10.1111/cas.12828

    PubMed

  • Diffuse-type gastric cancer cells switch their driver pathways from FGFR2 signaling to SDF1/CXCR4 axis in hypoxic tumor microenvironments Reviewed

    Kinoshita Haruhito, Yashiro Masakazu, Fukuoka Tatsunari, Hasegawa Tsuyoshi, Morisaki Tamami, Kasashima Hiroaki, Masuda Go, Noda Satoru, Hirakawa Kosei

    CARCINOGENESIS   36 ( 12 )   1511 - 1520   2015.12( ISSN:0143-3334

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    DOI: 10.1093/carcin/bgv134

    PubMed

  • ヒト癌における哺乳類ラパマイシンキナーゼ標的蛋白質の形質転換体細胞変異(Transforming somatic mutations of mammalian target of rapamycin kinase in human cancer) Reviewed

    Yamaguchi Hiroyuki, Kawazu Masahito, Yasuda Takahiko, Soda Manabu, Ueno Toshihide, Kojima Shinya, Yashiro Masakazu, Yoshino Ichiro, Ishikawa Yuichi, Sai Eirin, Mano Hiroyuki

    John Wiley & Sons Australia, Ltd Cancer Science   106 ( 12 )   1687 - 1692   2015.12( ISSN:1347-9032

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    ヒト癌における哺乳類ラパマイシン標的蛋白質(mTOR)遺伝子自体が体細胞変異を経て癌遺伝子となるか検討した。大細胞神経内分泌癌試料において、2209位のアミノ酸がロイシンからバリンに置換したmTORの体細胞非同義変異を同定した。mTOR(L2209V)変異はマウス3T3線維芽細胞を用いるフォーカス形成アッセイで顕著な形質転換能を示し、p70 S6キナーゼ、S6リボソーム蛋白質、真核生物翻訳開始因子4E結合蛋白質1のリン酸化を誘導した。追加の腫瘍標本や癌ゲノム変異データベースから種々の癌でmTORの別の独立した非同義変異が28同定され、そのうち12が形質転換能を示した。以上より、癌の変異によりmTORは形質転換能を獲得するため、このような腫瘍はmTOR阻害剤による分子標的治療の候補となり得ると考えられた。

  • 4ヵ月のプレドニゾロン療法とポリープ切除術により完全寛解したCronkhite-Canada症候群(Cronkhite-Canada Syndrome with Complete Remission after Four Months of Prednisolone Therapy and Polypectomy) Reviewed

    Namikawa Hiroki, Takemoto Yasuhiko, Kamata Noriko, Yashiro Masakazu, Hirohashi Kazuhiro, Shuto Taichi

    Journal of General and Family Medicine   16 ( 4 )   297 - 301   2015.12( ISSN:2189-6577

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    Publishing type:Research paper (scientific journal)  

    66歳男。脱毛症、味覚異常および下痢のため受診した。全身性脱毛、爪異栄養症、皮膚色素沈着および両下肢浮腫がみられ、リウマチ因子、メタロプロテアーゼ3および抗CCP抗体の上昇から自己免疫疾患が疑われた。上部消化管内視鏡および大腸鏡検査にて胃、十二指腸および結腸にポリープが観察された。以上の所見はCronkhite-Canada症候群(CCS)に一致した。生検にて胃ポリープに過形成、結腸ポリープに過形成および腺腫がみられた。CCSの診断後速やかに経口プレドニゾロン療法を開始し、症状の著明な改善を得た。4ヵ月間のプレドニゾロン漸減投与により上部消化管ポリープは消失し、残存していた4個の結腸ポリープは切除された。結腸ポリープの1つに粘膜内腺癌が発見されたが、断端に悪性所見はなく、CCSの完全寛解が確認された。プレドニゾロン療法中止から9ヵ月現在、再発はみられなかった。

  • Diffuse-type gastric cancer cells switch their driver pathways from FGFR2 signaling to SDF1/CXCR4 axis in hypoxic tumor microenvironments Reviewed

    Haruhito Kinoshita, Masakazu Yashiro, Tatsunari Fukuoka, Tsuyoshi Hasegawa, Tamami Morisaki, Hiroaki Kasashima, Go Masuda, Satoru Noda, Kosei Hirakawa

    CARCINOGENESIS   36 ( 12 )   1511 - 20   2015.12( ISSN:0143-3334 ( eISSN:1460-2180

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    Cancer-associated fibroblasts (CAFs) have been considered to play an important role for tumor progression of cancer. Solid tumors contain heterogeneous distribution of oxygen in their microenvironments. This study investigated the growth signaling of gastric cancer (GC) cells in focus on the interaction with CAFs and GC cells under normoxia and hypoxia. Four diffuse-type GC cell lines, two intestinal-type GC cell lines and three CAF cell lines were used. Cells were examined for expression of C-X-C chemokine receptor 4 (CXCR4), fibroblast growth factor receptor 2 (FGFR2) and stromal-derived factor 1 (SDF1) by RT-PCR, western blot, ELISA and immunohistochemical staining of xenografted tumors. GC cell proliferation was examined under hypoxia in the presence or absence of CAFs, a FGFR2 inhibitor, a CXCR4 inhibitor and HIF1a siRNA. Proliferation of diffuse-type GC cells, but not intestinal-type GC cells, was significantly increased by CAFs. CXCR4 expression by diffuse-type GC cells was significantly increased in hypoxia, while FGFR2 expression was decreased. CXCR4 expression was correlated with hypoxic microenvironment of xenografted tumor, but FGFR2 expression was not. FGFR2 inhibition significantly decreased the growth-stimulating activity of CAFs for diffuse-type GC cells in normoxia. In contrast, CXCR4 inhibition significantly decreased the growth-stimulating activity of CAFs in hypoxia. SDF1 production by CAFs was increased in hypoxia, while cancer cells did not produce SDF1. HIF1 siRNA significantly decreased both CXCR4 expression by diffuse-type GC cells and SDF1 production by CAFs. These findings suggest that diffuse-type GC cells might switch their driver pathways from FGFR2 signaling to SDF1/CXCR4 axis through HIF1 in hypoxic tumor microenvironments.

    DOI: 10.1093/carcin/bgv134

    PubMed

  • ヒト癌における哺乳類ラパマイシンキナーゼ標的蛋白質の形質転換体細胞変異(Transforming somatic mutations of mammalian target of rapamycin kinase in human cancer) Reviewed

    Yamaguchi Hiroyuki, Kawazu Masahito, Yasuda Takahiko, Soda Manabu, Ueno Toshihide, Kojima Shinya, Yashiro Masakazu, Yoshino Ichiro, Ishikawa Yuichi, Sai Eirin, Mano Hiroyuki

    Cancer Science   106 ( 12 )   1687 - 1692   2015.12( ISSN:1347-9032

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    Publishing type:Research paper (scientific journal)  

    ヒト癌における哺乳類ラパマイシン標的蛋白質(mTOR)遺伝子自体が体細胞変異を経て癌遺伝子となるか検討した。大細胞神経内分泌癌試料において、2209位のアミノ酸がロイシンからバリンに置換したmTORの体細胞非同義変異を同定した。mTOR(L2209V)変異はマウス3T3線維芽細胞を用いるフォーカス形成アッセイで顕著な形質転換能を示し、p70 S6キナーゼ、S6リボソーム蛋白質、真核生物翻訳開始因子4E結合蛋白質1のリン酸化を誘導した。追加の腫瘍標本や癌ゲノム変異データベースから種々の癌でmTORの別の独立した非同義変異が28同定され、そのうち12が形質転換能を示した。以上より、癌の変異によりmTORは形質転換能を獲得するため、このような腫瘍はmTOR阻害剤による分子標的治療の候補となり得ると考えられた。

  • Transforming somatic mutations of mammalian target of rapamycin kinase in human cancer Reviewed

    Hiroyuki Yamaguchi, Masahito Kawazu, Takahiko Yasuda, Manabu Soda, Toshihide Ueno, Shinya Kojima, Masakazu Yashiro, Ichiro Yoshino, Yuichi Ishikawa, Eirin Sai, Hiroyuki Mano

    CANCER SCIENCE   106 ( 12 )   1687 - 92   2015.12( ISSN:1347-9032 ( eISSN:1349-7006

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    Mammalian target of rapamycin (mTOR) is a serine-threonine kinase that acts downstream of the phosphatidylinositol 3-kinase signaling pathway and regulates a wide range of cellular functions including transcription, translation, proliferation, apoptosis, and autophagy. Whereas genetic alterations that result in mTOR activation are frequently present in human cancers, whether the mTOR gene itself becomes an oncogene through somatic mutation has remained unclear. We have now identified a somatic non-synonymous mutation of mTOR that results in a leucine-to-valine substitution at amino acid position 2209 in a specimen of large cell neuroendocrine carcinoma. The mTOR(L2209V) mutant manifested marked transforming potential in a focus formation assay with mouse 3T3 fibroblasts, and it induced the phosphorylation of p70 S6 kinase, S6 ribosomal protein, and eukaryotic translation initiation factor 4E-binding protein 1 in these cells. Examination of additional tumor specimens as well as public and in-house databases of cancer genome mutations identified another 28 independent non-synonymous mutations of mTOR in various cancer types, with 12 of these mutations also showing transforming ability. Most of these oncogenic mutations cluster at the interface between the kinase domain and the FAT (FRAP, ATM, TRRAP) domain in the 3-D structure of mTOR. Transforming mTOR mutants were also found to promote 3T3 cell survival, and their oncogenic activity was sensitive to rapamycin. Our data thus show that mTOR acquires transforming activity through genetic changes in cancer, and they suggest that such tumors may be candidates for molecularly targeted therapy with mTOR inhibitors.

    DOI: 10.1111/cas.12828

    PubMed

  • 4ヵ月のプレドニゾロン療法とポリープ切除術により完全寛解したCronkhite-Canada症候群(Cronkhite-Canada Syndrome with Complete Remission after Four Months of Prednisolone Therapy and Polypectomy) Reviewed

    Namikawa Hiroki, Takemoto Yasuhiko, Kamata Noriko, Yashiro Masakazu, Hirohashi Kazuhiro, Shuto Taichi

    (一社)日本プライマリ・ケア連合学会 Journal of General and Family Medicine   16 ( 4 )   297 - 301   2015.12( ISSN:2189-6577

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    Publishing type:Research paper (scientific journal)  

    66歳男。脱毛症、味覚異常および下痢のため受診した。全身性脱毛、爪異栄養症、皮膚色素沈着および両下肢浮腫がみられ、リウマチ因子、メタロプロテアーゼ3および抗CCP抗体の上昇から自己免疫疾患が疑われた。上部消化管内視鏡および大腸鏡検査にて胃、十二指腸および結腸にポリープが観察された。以上の所見はCronkhite-Canada症候群(CCS)に一致した。生検にて胃ポリープに過形成、結腸ポリープに過形成および腺腫がみられた。CCSの診断後速やかに経口プレドニゾロン療法を開始し、症状の著明な改善を得た。4ヵ月間のプレドニゾロン漸減投与により上部消化管ポリープは消失し、残存していた4個の結腸ポリープは切除された。結腸ポリープの1つに粘膜内腺癌が発見されたが、断端に悪性所見はなく、CCSの完全寛解が確認された。プレドニゾロン療法中止から9ヵ月現在、再発はみられなかった。

  • Cronkhite-Canada Syndrome with Complete Remission after Four Months of Prednisolone Therapy and Polypectomy Reviewed

    Namikawa Hiroki, Takemoto Yasuhiko, Kamata Noriko, Yashiro Masakazu, Hirohashi Kazuhiro, Shuto Taichi

    JOURNAL OF GENERAL AND FAMILY MEDICINE   16 ( 4 )   297 - 301   2015.12( ISSN:2189-7948

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  • Polymeric Micelle Platform for Multimodal Tomographic Imaging to Detect Scirrhous Gastric Cancer. Reviewed

    Miura Y, Tsuji AB, Sugyo A, Sudo H, Aoki I, Inubushi M, Yashiro M, Hirakawa K, Cabral H, Nishiyama N, Saga T, Kataoka K

    ACS biomaterials science & engineering   1 ( 11 )   1067 - 1076   2015.11

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    DOI: 10.1021/acsbiomaterials.5b00142

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  • Is Anaplastic Pancreatic Cancer Originated from Invasive Ductal Carcinoma of Pancreas? Reviewed

    Miura K., Kimura K., Amano R., Yamazoe S., Ohira G., Nishio K., Shibutani M., Sakurai K., Nagahara H., Toyokawa T., Kubo N., Tanaka H., Muguruma K., Otani H., Yashiro M., Maeda K., Ohira M., Hirakawa K.

    PANCREAS   44 ( 8 )   1398 - 1398   2015.11( ISSN:0885-3177

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  • Polymeric Micelle Platform for Multimodal Tomographic Imaging to Detect Scirrhous Gastric Cancer Reviewed

    Miura Yutaka, Tsuji Atsushi B., Sugyo Aya, Sudo Hitomi, Aok Ichio, Inubushi Masayuki, Yashiro Masakazu, Hirakawa Kosei, Cabral Horacio, Nishiyama Nobuhiro, Saga Tsuneo, Kataoka Kazunori

    ACS BIOMATERIALS SCIENCE & ENGINEERING   1 ( 11 )   1067 - 1076   2015.11( ISSN:2373-9878

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    DOI: 10.1021/acsbiomaterials.5b00142

  • Binding of Galectin-3, a beta-Galactoside-binding Lectin, to MUC1 Protein Enhances Phosphorylation of Extracellular Signal-regulated Kinase 1/2 (ERK1/2) and Akt, Promoting Tumor Cell Malignancy Reviewed

    Mori Yugo, Akita Kaoru, Yashiro Masakazu, Sawada Tetsuji, Hirakawa Kosei, Murata Takeomi, Nakada Hiroshi

    JOURNAL OF BIOLOGICAL CHEMISTRY   290 ( 43 )   26125 - 26140   2015.10( ISSN:0021-9258

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    DOI: 10.1074/jbc.M115.651489

    PubMed

  • Binding of Galectin-3, a beta-Galactoside-binding Lectin, to MUC1 Protein Enhances Phosphorylation of Extracellular Signal-regulated Kinase 1/2 (ERK1/2) and Akt, Promoting Tumor Cell Malignancy Reviewed

    Yugo Mori, Kaoru Akita, Masakazu Yashiro, Tetsuji Sawada, Kosei Hirakawa, Takeomi Murata, Hiroshi Nakada

    JOURNAL OF BIOLOGICAL CHEMISTRY   290 ( 43 )   26125 - 40   2015.10( ISSN:0021-9258 ( eISSN:1083-351X

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    Both mucin 1 (MUC1) and galectin-3 are known to be over-expressed in various malignant tumors and associated with a poor prognosis. It has been extensively reported that MUC1 is involved in potentiation of growth factor-dependent signal transduction. Because some carbohydrate moieties carried on MUC1 change to preferable ones for binding of galectin-3 in cancer cells, we speculated that MUC1-mediated signaling may occur through direct binding of galectin-3. Immunochemical studies showed that the distribution of galectin-3 coincided with that of MUC1 in various human tumor tissues but not in human nonmalignant tissues, and the level of galectin-3 retained on the surface of various cancer cells paralleled that of MUC1. Treatment of MUC1-expressing cells with galectin-3 induced phosphorylation of ERK1/2 and Akt following enhanced phosphorylation of MUC1 C-terminal domain, consistently promoting tumor cell malignancy. It is also noted that this enhanced phosphorylation occurred independently of EGF receptor-mediated signaling in both EGF receptor-and MUC1-expressing cells, and multivalency of galectin-3 was important for initiation of MUC1-mediated signaling. Expectedly, both silencing of endogenous galectin-3 and treatment with galectin-3 antagonists down-regulated cell proliferation of MUC1-expressing cells. These results suggest that the binding of galectin-3 to MUC1 plays a key role in MUC1-mediated signaling. Thus, constitutive activation of MUC1-mediated signaling in an autocrine/paracrine manner caused by ligation of galectin-3 promotes uncontrolled tumor cell malignancy. This signaling may be another MUC1-mediated pathway and function in parallel with a growth factor-dependent MUC1-mediated signaling pathway.

    DOI: 10.1074/jbc.M115.651489

    PubMed

  • Identification of tumour-reactive lymphatic endothelial cells capable of inducing progression of gastric cancer Reviewed

    Tokumoto Mao Watanabe, Tanaka Hiroaki, Tauchi Yukie, Kasashima Hiroaki, Kurata Kento, Yashiro Masakazu, Sakurai Katsunobu, Toyokawa Takahiro, Kubo Naoshi, Amano Ryosuke, Kimura Kenjiro, Muguruma Kazuya, Maeda Kiyoshi, Ohira Masaichi, Hirakawa Kosei

    BRITISH JOURNAL OF CANCER   113 ( 7 )   1046 - 1054   2015.09( ISSN:0007-0920

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    DOI: 10.1038/bjc.2015.282

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  • Identification of tumour-reactive lymphatic endothelial cells capable of inducing progression of gastric cancer Reviewed

    Mao Watanabe Tokumoto, Hiroaki Tanaka, Yukie Tauchi, Hiroaki Kasashima, Kento Kurata, Masakazu Yashiro, Katsunobu Sakurai, Takahiro Toyokawa, Naoshi Kubo, Ryosuke Amano, Kenjiro Kimura, Kazuya Muguruma, Kiyoshi Maeda, Masaichi Ohira, Kosei Hirakawa

    BRITISH JOURNAL OF CANCER   113 ( 7 )   1046 - 54   2015.09( ISSN:0007-0920 ( eISSN:1532-1827

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    Background: Tumour cells and stromal cells interact in the tumour microenvironment; moreover, stromal cells can acquire abnormalities that contribute to tumour progression. However, interactions between lymphatic endothelial cells (LECs) and tumour cells are largely unexamined. In this study, we aimed to determine whether tumour-specific LECs inhabit the tumour microenvironment and examine their influence on this microenvironment.
    Methods: We isolated normal LECs (NLECs) from a non-metastatic lymph node and tumour-associated LECs (TLECs) from cancerous lymph nodes. We examined proliferative and migratory potency, growth factor production, and gene expression of each type of LEC. Moreover, we developed a co-culture system to investigate the interactions between gastric cancer cells and LECs.
    Results: When compared with NLEC, TLECs had an abnormal shape, high proliferative and migratory abilities, and elevated expression of genes associated with inflammation, cell growth, and cell migration. NLECs co-cultured with gastric cancer cells from the OCUM12 cell line acquired TLEC-like phenotypes. Also, OCUM12 cells co-cultured with TLECs expressed high levels of genes responsible for metastasis.
    Conclusions: Our results demonstrated that LECs interacted with tumour cells and obtained abnormal phenotypes that could have important roles in tumour progression.

    DOI: 10.1038/bjc.2015.282

    PubMed

  • Prostaglandin D synthase is a potential novel therapeutic agent for the treatment of gastric carcinomas expressing PPAR gamma Reviewed

    Fukuoka Tatsunari, Yashiro Masakazu, Kinoshita Haruhito, Morisaki Tamami, Hasegawa Tsuyoshi, Hirakawa Toshiki, Aomatsu Naoki, Takeda Hiroshi, Maruyama Takayuki, Hirakawa Kosei

    INTERNATIONAL JOURNAL OF CANCER   137 ( 5 )   1235 - 1244   2015.09( ISSN:0020-7136

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    DOI: 10.1002/ijc.29392

    PubMed

  • Prostaglandin D synthase is a potential novel therapeutic agent for the treatment of gastric carcinomas expressing PPAR gamma Reviewed

    Tatsunari Fukuoka, Masakazu Yashiro, Haruhito Kinoshita, Tamami Morisaki, Tsuyoshi Hasegawa, Toshiki Hirakawa, Naoki Aomatsu, Hiroshi Takeda, Takayuki Maruyama, Kosei Hirakawa

    INTERNATIONAL JOURNAL OF CANCER   137 ( 5 )   1235 - 44   2015.09( ISSN:0020-7136 ( eISSN:1097-0215

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    The antitumor activity of prostaglandin (PG) D-2 has been demonstrated against some types of cancer, including gastric cancer. However, exogenous PGD(2) is not useful from a clinical point of view because it is rapidly metabolized in vivo. The aim of this study was to clarify the antitumor efficacy of an alternative, PGD synthase (PGDS), on gastric cancer cells. The effects of PGD(2) and PGDS on the proliferation of gastric cancer cells were examined in vivo and in vitro. The expression levels of PGD(2) receptors and peroxisome proliferator-activated receptor (PPAR) were evaluated by RT-PCR. The effects of a PPAR antagonist or siPPAR on the proliferation of cancer cells and the c-myc and cyclin D1 expression were examined in the presence or absence of PGD(2) or PGDS. PPAR was expressed in gastric cancer cell lines, but PGD(2) receptors were not. PGD(2) and PGDS significantly decreased the proliferation of gastric cancer cells that highly expressed PPAR. PGDS increased the PGD(2) production of gastric cancer cells. A PPAR antagonist and siPPAR transfection significantly suppressed the growth-inhibitory effects of PGD(2) and PGDS. Expression of c-myc and cyclin D1 was significantly decreased by PGD(2); this inhibitory effect was suppressed by PPAR antagonist. Both PGD(2) and PGDS significantly decreased subcutaneous tumor growth in vivo. Tumor volume after PGDS treatment was significantly less than PGD(2) treatment. These findings suggest that PGDS and PGD(2) decrease the proliferation of gastric cancer cells through PPAR signaling. PGDS is a potentially promising therapeutic agent for gastric cancers that express PPAR.
    What's new? Previous work suggests that prostaglandin D-2 (PGD(2)) exerts antiproliferative effects in certain types of cancer cells. But because PGD(2) is rapidly catalyzed to its inactive form, its clinical utility is limited. A possible alternative to PGD(2) is PGD synthase (PGDS), which synthesizes PGD2, but whether it also possesses antitumor activity is unknown. In this study, in PPAR-expressing gastric cancer cells, both PGD(2) and PGDS were found to significantly suppress cell proliferation. In vivo, they inhibited the growth of subcutaneous tumors. Tumor volume was markedly decreased with PGDS treatment, compared with PGD(2).

    DOI: 10.1002/ijc.29392

    PubMed

  • Epithelial mesenchymal transition may contribute to anaplastic change of pancreatic ductal adenocarcinoma Reviewed

    Miura Kotaro, Kimura Kenjiro, Amano Ryosuke, Yamazoe Sadaaki, Ohira Go, Nishio Kohei, Shibutani Masatsune, Sakurai Katsunobu, Nagahara Hisashi, Toyokawa Takahiro, Kubo Naoshi, Tanaka Hiroaki, Muguruma Kazuya, Otani Hiroshi, Yashiro Masakazu, Maeda Kiyoshi, Ohira Masaichi, Hirakawa Kosei

    CANCER RESEARCH   75   2015.08( ISSN:0008-5472

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    DOI: 10.1158/1538-7445.AM2015-5276

  • Novel biomarkers for gastric cancer stem cells utilizing comparative proteomics analysis Reviewed

    Yashiro Masakazu, Morisaki Tamami, Hasegawa Tsuyoshi, Kakehashi Anna, Kinoshita Haruhito, Fukuoka Tatsunari, Kasashima Hiroaki, Masuda Go, Sakurai Katsunobu, Kubo Naoshi, Tanaka Hiroaki, Muguruma Kazuya, Ohira Masaichi, Wanibuchi Hideki, Hirakawa Kosei

    CANCER RESEARCH   75   2015.08( ISSN:0008-5472

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    DOI: 10.1158/1538-7445.AM2015-1405

  • Lysyl oxidase-like 2 (LOXL2) from cancer-associated fibroblasts stimulates the progression of gastric carcinoma Reviewed

    Kasashima Hiroaki, Yashiro Masakazu, Kitayama Kisyu, Masuda Go, Kinoshita Haruhito, Sakurai Katsunobu, Toyokawa Takahiro, Kubo Naoshi, Tanaka Hiroaki, Muguruma Kazuya, Ohira Masaichi, Hirakawa Kosei

    CANCER RESEARCH   75   2015.08( ISSN:0008-5472

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    DOI: 10.1158/1538-7445.AM2015-5063

  • SDF1 alpha/CXCR4 axis might be associated with growth-interaction between cancer-associated fibroblasts and gastric cancer cells in hypoxic tumor microenvironment Reviewed

    Kinoshita Haruhito, Yashiro Masakazu, Kasashima Hiroaki, Masuda Go, Morisaki Tamami, Fukuoka Tatsunari, Sakurai Katsunobu, Toyokawa Takahiro, Kimura Kenjiro, Kubo Naoshi, Tanaka Hiroaki, Muguruma Kazuya, Ohira Masaichi, Hirakawa Kosei

    CANCER RESEARCH   75   2015.08( ISSN:0008-5472

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    DOI: 10.1158/1538-7445.AM2015-436

  • Significance of an autophagy protein, microtubule-associated protein light chain 3 (LC3), in gastric cancer Reviewed

    Masuda Go, Yashiro Masakazu, Kasashima Hiroaki, Kinoshita Haruhito, Fukuoka Tatsunari, Morisaki Tamami, Hasegawa Tsuyoshi, Sakurai Katsunobu, Toyokawa Takahiro, Kubo Naoshi, Tanaka Hiroaki, Muguruma Kazuya, Ohira Masaichi, Chung Kosei

    CANCER RESEARCH   75   2015.08( ISSN:0008-5472

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    DOI: 10.1158/1538-7445.AM2015-992

  • Molecular Alterations of Colorectal Cancer with Inflammatory Bowel Disease Reviewed

    Yashiro Masakazu

    DIGESTIVE DISEASES AND SCIENCES   60 ( 8 )   2251 - 2263   2015.08( ISSN:0163-2116

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    Publishing type:Research paper (scientific journal)   Kind of work:Single Work  

    DOI: 10.1007/s10620-015-3646-4

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  • Molecular Alterations of Colorectal Cancer with Inflammatory Bowel Disease Reviewed

    Masakazu Yashiro

    DIGESTIVE DISEASES AND SCIENCES   60 ( 8 )   2251 - 63   2015.08( ISSN:0163-2116 ( eISSN:1573-2568

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    Inflammatory bowel disease (IBD) is an important etiologic factor in the development of colorectal cancer (CRC). The risk of CRC begins to increase 8 or 10 years after the diagnosis of IBD. This type of cancer is called colitis-associated CRC (CA-CRC). The molecular pathogenesis of inflammatory epithelium might play a critical role in the development of CA-CRC. Genetic alterations detected in CA-CRC such as genetic mutations, microsatellite instability, and DNA hypermethylation are also recognized in sporadic CRC; however, there are differences in the timing and frequency of molecular events between CA-CRC and sporadic CRC. Interaction between gene-environmental factors, including inflammation, lifestyle, psychological stress, and prior appendectomy, might be associated with the etiopathology of IBD. The mucosal inflammatory mediators, such as oxidant stress, free radicals, and chemokines, may cause the genetic alterations. Understanding the molecular mechanisms of CA-CRC might be important to develop clinical efficacies for patients with IBD. This review discusses the molecular characteristics of CA-CRC, especially ulcerative colitis-associated CRC, including clinical features, signaling pathways, and interactions between genetic alterations and environment involved in inflammatory carcinogenesis.

    DOI: 10.1007/s10620-015-3646-4

    PubMed

  • Bone marrow-derived stromal cells are associated with gastric cancer progression Reviewed

    Kasashima H., Yashiro M., Nakamae H., Masuda G., Kinoshita H., Morisaki T., Fukuoka T., Hasegawa T., Sakurai K., Toyokawa T., Kubo N., Tanaka H., Muguruma K., Ohira M., Nakane T., Hino M., Hirakawa K.

    BRITISH JOURNAL OF CANCER   113 ( 3 )   443 - 452   2015.07( ISSN:0007-0920

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    DOI: 10.1038/bjc.2015.236

  • Bone marrow-derived stromal cells are associated with gastric cancer progression. Reviewed

    Kasashima H, Yashiro M, Nakamae H, Masuda G, Kinoshita H, Morisaki T, Fukuoka T, Hasegawa T, Sakurai K, Toyokawa T, Kubo N, Tanaka H, Muguruma K, Ohira M, Nakane T, Hino M, Hirakawa K

    British journal of cancer   113 ( 3 )   443 - 52   2015.07( ISSN:0007-0920

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    DOI: 10.1038/bjc.2015.236

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  • Exosomal miRNAs from Peritoneum Lavage Fluid as Potential Prognostic Biomarkers of Peritoneal Metastasis in Gastric Cancer Reviewed

    Tokuhisa Motohiko, Ichikawa Yasushi, Kosaka Nobuyoshi, Ochiya Takahiro, Yashiro Masakazu, Hirakawa Kosei, Kosaka Takashi, Makino Hirochika, Akiyama Hirotoshi, Kunisaki Chikara, Endo Itaru

    PLOS ONE   10 ( 7 )   e0130472   2015.07( ISSN:1932-6203

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    DOI: 10.1371/journal.pone.0130472

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  • Tks5 activation in mesothelial cells creates invasion front of peritoneal carcinomatosis Reviewed

    Satoyoshi R., Aiba N., Yanagihara K., Yashiro M., Tanaka M.

    ONCOGENE   34 ( 24 )   3176 - 3187   2015.06( ISSN:0950-9232

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    DOI: 10.1038/onc.2014.246

  • Tks5 activation in mesothelial cells creates invasion front of peritoneal carcinomatosis. Reviewed

    Satoyoshi R, Aiba N, Yanagihara K, Yashiro M, Tanaka M

    Oncogene   34 ( 24 )   3176 - 87   2015.06( ISSN:0950-9232

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    DOI: 10.1038/onc.2014.246

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  • The Outcome of Surgical Treatment for Elderly Patients With Gastric Carcinoma Reviewed

    Sakurai Katsunobu, Muguruma Kazuya, Nagahara Hisashi, Kimura Kenjiro, Toyokawa Takahiro, Amano Ryosuke, Kubo Naoshi, Tanaka Hiroaki, Ohtani Hiroshi, Yashiro Masakazu, Maeda Kiyoshi, Ohira Masaichi, Hirakawa Kosei

    JOURNAL OF SURGICAL ONCOLOGY   111 ( 7 )   848 - 854   2015.06( ISSN:0022-4790

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    DOI: 10.1002/jso.23896

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  • The pretreatment Controlling Nutritional Status (CONUT) score as an independent prognostic factor in patients with clinical Stage I-III esophageal squamous cell carcinoma Reviewed

    Toyokawa T., Kubo N., Shibutani M., Sakurai K., Nagahara H., Tanaka H., Muguruma K., Ohtani H., Yashiro M., Maeda K., Ohira M., Hirakawa K.

    ANNALS OF ONCOLOGY   26   2015.06( ISSN:0923-7534

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    DOI: 10.1093/annonc/mdv233.45

  • The Outcome of Surgical Treatment for Elderly Patients With Gastric Carcinoma Reviewed

    Katsunobu Sakurai, Kazuya Muguruma, Hisashi Nagahara, Kenjiro Kimura, Takahiro Toyokawa, Ryosuke Amano, Naoshi Kubo, Hiroaki Tanaka, Hiroshi Ohtani, Masakazu Yashiro, Kiyoshi Maeda, Masaichi Ohira, Kosei Hirakawa

    JOURNAL OF SURGICAL ONCOLOGY   111 ( 7 )   848 - 54   2015.06( ISSN:0022-4790 ( eISSN:1096-9098

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    BackgroundThe aim of this study was to clarify the operative mortality and long-term survival of gastrectomy for elderly patients with gastric cancer.
    MethodsA total of 461 patients who underwent gastrectomy for gastric cancer in our hospital were classified as elderly group (80 years-old, 95 patients) and control group (60-69 years-old, 366 patients).
    ResultsThe frequency of comorbidities was significantly (P&lt;0.05) higher in elderly group (74.7%) than that in the control group (49.5%). No significant difference of the postoperative complication rate was found between the elderly group (23.2%) and the control group (23.2%). Adjuvant chemotherapy was 9.5% in the elderly group, which was significantly less than 29.0% of the control group (P&lt;0.05). Stage II and III elderly patients had worse disease specific survival (DSS) than controls did. In the elderly, overall survival (OS) was significantly worse than DSS in stage I patients (P&lt;0.05).
    ConclusionsThe operative complication rate of elderly patients was comparable to the control group. Comorbidity and occurrence of secondary malignant disease should be followed for elderly patients at stage I. For stage II and III disease patients, a novel drug which is acceptable for the elderly is needed as a postoperative therapy. J. Surg. Oncol. 2015 111:848-854. (c) 2014 Wiley Periodicals, Inc.

    DOI: 10.1002/jso.23896

    PubMed

  • Two-surgeon technique for liver transection using precoagulation by a soft-coagulation system and ultrasonic dissection. Reviewed

    Yamada N, Amano R, Kimura K, Murata A, Yashiro M, Tanaka S, Wakasa K, Hirakawa K

    Hepato-gastroenterology   62 ( 138 )   389 - 92   2015.03( ISSN:0172-6390

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  • リンパ流に沿ったリンパ節内マクロファージ数と胃癌リンパ節転移との関係 Reviewed

    田内 幸枝, 田中 浩明, 崎村 千恵, 徳本 真央, 櫻井 克宣, 豊川 貴弘, 久保 尚士, 六車 一哉, 八代 正和, 澤田 鉄二, 大平 雅一, 平川 弘聖

    日本胃癌学会総会記事   87回   288 - 288   2015.03

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  • 胃癌におけるオートファジー関連蛋白p62の臨床病理学的意義 Reviewed

    増田 剛, 八代 正和, 笠島 裕明, 田内 幸枝, 徳本 真央, 木下 春人, 福岡 達成, 森崎 珠美, 櫻井 克宣, 豊川 貴弘, 久保 尚士, 田中 浩明, 六車 一哉, 大平 雅一, 平川 弘聖

    日本胃癌学会総会記事   87回   277 - 277   2015.03

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  • Impact of Body Mass Index on Surgical Outcomes after Esophagectomy for Patients with Esophageal Squamous Cell Carcinoma Reviewed

    Hasegawa Tsuyoshi, Kubo Naoshi, Ohira Masaichi, Sakurai Katsunobu, Toyokawa Takahiro, Yamashita Yoshito, Yamazoe Sadaaki, Kimura Kenjiro, Nagahara Hisashi, Amano Ryosuke, Shibutani Masatsune, Tanaka Hiroaki, Muguruma Kazuya, Ohtani Hiroshi, Yashiro Masakazu, Maeda Kiyoshi, Hirakawa Kosei

    JOURNAL OF GASTROINTESTINAL SURGERY   19 ( 2 )   226 - 233   2015.02( ISSN:1091-255X

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s11605-014-2686-y

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  • Protein-bound polysaccharide K suppresses tumor fibrosis in gastric cancer by inhibiting the TGF-beta signaling pathway Reviewed

    Shinbo Toshifumi, Fushida Sachio, Tsukada Tomoya, Harada Shinichi, Kinoshita Jun, Oyama Katsunobu, Okamoto Koichi, Ninomiya Itasu, Takamura Hiroyuki, Kitagawa Hirohisa, Fujimura Takeshi, Yashiro Masakazu, Hirakawa Kousei, Ohta Tetsuo

    ONCOLOGY REPORTS   33 ( 2 )   553 - 558   2015.02( ISSN:1021-335X

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.3892/or.2014.3636

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  • Impact of Body Mass Index on Surgical Outcomes after Esophagectomy for Patients with Esophageal Squamous Cell Carcinoma Reviewed

    Tsuyoshi Hasegawa, Naoshi Kubo, Masaichi Ohira, Katsunobu Sakurai, Takahiro Toyokawa, Yoshito Yamashita, Sadaaki Yamazoe, Kenjiro Kimura, Hisashi Nagahara, Ryosuke Amano, Masatsune Shibutani, Hiroaki Tanaka, Kazuya Muguruma, Hiroshi Ohtani, Masakazu Yashiro, Kiyoshi Maeda, Kosei Hirakawa

    JOURNAL OF GASTROINTESTINAL SURGERY   19 ( 2 )   226 - 33   2015.02( ISSN:1091-255X ( eISSN:1873-4626

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    Patients with overweight reportedly have more comorbidities, including diabetes mellitus and cardiovascular disease, and longer operating times as well as more blood loss during surgery compared with those with normal weight. However, the impact of overweight on the short-term outcome after transthoracic esophagectomy for patients with esophageal squamous cell carcinoma (ESCC) remains unclear. We hypothesized that overweight has a negative impact on short-term surgical outcomes after esophagectomy for patients with ESCC.
    A total of 304 patients who underwent transthoracic esophagectomy for ESCC were included in this study. Body mass index (BMI) was classified into three categories, &lt; 18.49, 18.50-24.99, and &gt; 25.00 (kg/m(2)), defined as low, normal, and high BMI, respectively, according to the World Health Organization criteria. We investigated the association of BMI status with patient demographics and surgical outcomes after esophagectomy for patients with ESCC. In addition, overall survival and relapse-free survival stratified by BMI were compared.
    Fifty-nine (19.4 %) and 41 (13.4 %) patients were classified to low BMI and high BMI, respectively. The high-BMI group had significantly higher comorbidity rates of diabetes mellitus (p &lt; 0.01) and anastomotic leakage (p = 0.011) than the normal-BMI group. There were no significant association between high BMI and another various complications except for an anastomotic leakage, severe complications defined by Clavien-Dindo classification and in-hospital mortality. In multivariate analysis, high BMI was a significant risk factor for anastomotic leakage (p = 0.030, hazard ratio; 3.423, 95%CI; 1.128-10.38). On the other hand, no significant association was observed between low BMI and short surgical outcomes. There were no significant differences in overall and relapse-free survival among the three BMI groups in univariate and multivariate analysis (p = 0.128 and p = 0.584, respectively).
    The surgical treatment should not be denied for patients with ESCC due to overweight and underweight. However, intraoperative prevention and postoperative careful monitoring for anastomotic leakage might be required after esophagectomy for overweight patients with ESCC.

    DOI: 10.1007/s11605-014-2686-y

    PubMed

  • Protein-bound polysaccharide K suppresses tumor fibrosis in gastric cancer by inhibiting the TGF-beta signaling pathway Reviewed

    Toshifumi Shinbo, Sachio Fushida, Tomoya Tsukada, Shinichi Harada, Jun Kinoshita, Katsunobu Oyama, Koichi Okamoto, Itasu Ninomiya, Hiroyuki Takamura, Hirohisa Kitagawa, Takeshi Fujimura, Masakazu Yashiro, Kousei Hirakawa, Tetsuo Ohta

    ONCOLOGY REPORTS   33 ( 2 )   553 - 8   2015.02( ISSN:1021-335X ( eISSN:1791-2431

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    Peritoneal carcinomatosis (PC) is the most frequent metastatic pattern of gastric cancer and its prognosis is extremely poor. PC is characterized by rich fibrosis and the development of obstructive disorders such as ileus, jaundice and hydronephrosis. Epithelial-mesenchymal transition (EMT) is one of the major causes of tissue fibrosis and transforming growth factor beta (TGF-beta) has a pivotal function in the progression of EMT. Protein-bound polysaccharide K (PSK) is a biological response modifier that can modulate the TGF-beta/Smad signaling pathway in vitro. In the present study, we established a fibrotic tumor model using human peritoneal mesothelial cells (HPMCs) and a human gastric cancer cell line to evaluate whether PSK attenuates tumor fibrosis. HPMCs exposed to PSK did not undergo the morphological change from a cobblestone-like pattern to a spindle-shape pattern normally induced by treatment with TGF-beta. Immunofluorescence further demonstrated that PSK suppressed TGF-beta-induced overexpression of alpha-SMA in the HPMCs. We further showed that HPMCs contributed to the proliferation of tumor fibrosis by using a mouse xenograft model. Additionally, PSK treatment of these mice significantly reduced the area of observable tumor fibrosis. These results suggest that seeded cancer cells transformed HPMCs into myofibroblast-like cells through their release of TGF-beta in the microenvironment, facilitating the development of fibrous tumors in organs covered with HPMCs. Therefore, our study indicates that PSK has potential utility as an anti-fibrotic agent in the treatment of gastric cancer patients with PC.

    DOI: 10.3892/or.2014.3636

    PubMed

  • Asporin activates coordinated invasion of scirrhous gastric cancer and cancer-associated fibroblasts Reviewed

    Satoyoshi R., Kuriyama S., Aiba N., Yashiro M., Tanaka M.

    ONCOGENE   34 ( 5 )   650 - 660   2015.01( ISSN:0950-9232

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    DOI: 10.1038/onc.2013.584

  • Asporin activates coordinated invasion of scirrhous gastric cancer and cancer-associated fibroblasts. Reviewed

    Satoyoshi R, Kuriyama S, Aiba N, Yashiro M, Tanaka M

    Oncogene   34 ( 5 )   650 - 60   2015.01( ISSN:0950-9232

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    DOI: 10.1038/onc.2013.584

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  • Sentinel node navigation surgery for gastric cancer: Overview and perspective Reviewed

    Yashiro Masakazu, Matsuoka Tasuku

    WORLD JOURNAL OF GASTROINTESTINAL SURGERY   7 ( 1 )   1 - 9   2015.01( ISSN:1948-9366

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    DOI: 10.4240/wjgs.v7.i1.1

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  • Sentinel node navigation surgery for gastric cancer: Overview and perspective. Reviewed

    Yashiro M, Matsuoka T

    World journal of gastrointestinal surgery   7 ( 1 )   1 - 9   2015.01( ISSN:1948-9366

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    DOI: 10.4240/wjgs.v7.i1.1

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  • Recent advances in the HER2 targeted therapy of gastric cancer Reviewed

    Matsuoka Tasuku, Yashiro Masakazu

    WORLD JOURNAL OF CLINICAL CASES   3 ( 1 )   42 - 51   2015.01( ISSN:2307-8960

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    DOI: 10.12998/wjcc.v3.i1.42

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  • Recent advances in the HER2 targeted therapy of gastric cancer Reviewed

    Tasuku Matsuoka, Masakazu Yashiro

    WORLD JOURNAL OF CLINICAL CASES   3 ( 1 )   42 - 51   2015.01( ISSN:2307-8960

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    Recent advances in molecular targeted therapies, including targeting human epidermal growth factor receptor 2 (HER2), had a major forward step in the therapy for gastric cancer patients. Application of HER2-targeted therapies, in particular trastuzumab in combination with chemotherapy in metastatic HER2-positive gastric cancers, resulted in improvements in response rates, time to progression and overall survival. Nevertheless, as with breast cancer, many patients with gastric cancer develop resistance to trastuzumab. Several promising therapies are currently being developed in combination with chemotherapy to increase the efficacy and overcome the cancer-resistance. Here we review the current overview of clinical application of agents targeting HER2 in gastric cancer. We also discuss the ongoing trials supporting the use of HER2-targeted agents combined with cytotoxic agents or other monoclonal antibodies.

    DOI: 10.12998/wjcc.v3.i1.42

    PubMed

  • Agr2 Mediates Paracrine Effects on Stromal Fibroblasts That Promote Invasion by Gastric Signet-Ring Carcinoma Cells Reviewed

    Tsuji Tadahiro, Satoyoshi Rika, Aiba Namiko, Kubo Takanori, Yanagihara Kazuyoshi, Maeda Daichi, Goto Akiteru, Ishikawa Kazuo, Yashiro Masakazu, Tanaka Masamitsu

    CANCER RESEARCH   75 ( 2 )   356 - 366   2015.01( ISSN:0008-5472

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    DOI: 10.1158/0008-5472.CAN-14-1693

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  • Agr2 Mediates Paracrine Effects on Stromal Fibroblasts That Promote Invasion by Gastric Signet-Ring Carcinoma Cells Reviewed

    Tadahiro Tsuji, Rika Satoyoshi, Namiko Aiba, Takanori Kubo, Kazuyoshi Yanagihara, Daichi Maeda, Akiteru Goto, Kazuo Ishikawa, Masakazu Yashiro, Masamitsu Tanaka

    CANCER RESEARCH   75 ( 2 )   356 - 66   2015.01( ISSN:0008-5472 ( eISSN:1538-7445

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    Agr2 is a disulfide isomerase residing in the endoplasmic reticulum (ER), which physiologically regulates protein folding and mediates resistance to ER stress. Agr2 is overexpressed in adenocarcinomas of various organs, where it participates in neoplastic transformation and metastasis, therefore acts as a pro-oncogenic protein. Besides its normal localization in the ER, Agr2 is also found in the serum and urine of cancer patients, although the physiological significance of extracellular Agr2 is poorly understood. In this study, we demonstrated that extracellular Agr2 can activate stromal fibroblasts and promote fibroblast-associated cancer invasion in gastric signet-ring cell carcinoma (SRCC), where Agr2 is highly expressed. Agr2 secreted from SRCC cells was incorporated by the surrounding gastric fibroblasts and promoted invasion by these cells. In turn, activated fibroblasts coordinated the invasive behavior of fibroblasts and cancer cells. Our findings suggested that Agr2 drives progression of gastric SRCC by exerting paracrine effects on fibroblasts in the tumor microenvironment, acting also to increase the growth and resistance of SRCC cells to oxidative and hypoxic stress as cell autonomous effects. (C) 2014 AACR.

    DOI: 10.1158/0008-5472.CAN-14-1693

    PubMed

  • CD133 as biomarker in breast cancer Reviewed

    Tasuku Matsuoka, Masakazu Yashiro

    Biomarkers in Disease: Methods, Discoveries and Applications: Biomarkers in Cancer   429 - 445   2015.01

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    Breast cancer is one of the most common malignant diseases worldwide. Prognosis of breast cancer is still poor despite the diagnostic and therapeutic progress in recent years. In order to decrease breast cancer-related deaths, many studies are aimed at identifying novel screening- and prognosis-related biomarkers. Cancer stem cells (CSCs) are characterized by the capacity for self-renewal, tumorigenesis, and differentiation. Due to the role of cancer stem cells in tumor initiation and treatment failure, studies of CSC markers have been of great interest. CD133, five transmembrane single-chain glycoproteins, has been successfully used as a stem cell marker to identify and isolate CSCs in malignant tumors. CD133 can also be used to predict tumor metastasis, patient survival and resistance to therapy. This chapter provides an overview of the evidence regarding the existence and function of CD133 in breast cancers in the context of the experimental and clinical data. It also discusses CD133 as a possible target for breast cancer therapy.

    DOI: 10.1007/978-94-007-7681-4_24

  • Epigenetic modulation and repression of miR-200b by cancer-associated fibroblasts contribute to cancer invasion and peritoneal dissemination in gastric cancer Reviewed

    Kurashige Junji, Mima Kosuke, Sawada Genta, Takahashi Yusuke, Eguchi Hidetoshi, Sugimachi Keishi, Mori Masaki, Yanagihara Kazuyoshi, Yashiro Masakazu, Hirakawa Kosei, Baba Hideo, Mimori Koshi

    CARCINOGENESIS   36 ( 1 )   133 - 141   2015.01( ISSN:0143-3334

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    DOI: 10.1093/carcin/bgu232

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  • G-factorを加えたTNM分類による胃癌の新規分子ステージング 日本消化器癌発生学会のGプロジェクト委員会による多施設共同研究(New molecular staging with G-factor supplements TNM classification in gastric cancer: a multicenter collaborative research by the Japan Society for Gastroenterological Carcinogenesis G-Project committee) Reviewed

    Sawada Tetsuji, Yashiro Masakazu, Sentani Kazuhiro, Oue Naohide, Yasui Wataru, Miyazaki Kohji, Kai Keita, Fushida Sachio, Fujimura Takashi, Ohira Masaichi, Kakeji Yoshihiro, Natsugoe Shoji, Shirabe Ken, Nomura Sachiyo, Shimada Yutaka, Tomita Naohiro, Hirakawa Kosei, Maehara Yoshihiko

    シュプリンガー・ジャパン(株) Gastric Cancer   18 ( 1 )   119 - 128   2015.01( ISSN:1436-3291

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    Gプロジェクト委員会では、従来のTNM分類に分子生物学的特性に基づくG-factorを加えた新たな分類スキームを考案している。今回、胃癌に関する論文を検索し、G-factorの候補として8分子を選定した。根治的R0切除術を受けた胃癌患者210例から得られた切除標本を用いて、8分子に対する免疫染色を行い、臨床病理学的因子と各分子の発現との関連について検討した。8分子の免疫染色発現と術後再発の間に有意な相関は観察されなかった。しかし、p53およびマトリックスメタロプロテイナーゼ-7(MMP-7)の発現は全生存(OS)と有意に相関した。p53およびMMP-7の発現に基づいて210例を3群に分けた場合(G0群:両分子ともに陰性、G1群:どちらかが陽性、G2群:両分子ともに陽性)、G2群はG0群に比して有意に高い再発率を示した。多変量解析では、G2群が短い無病生存(DFS)と独立して関連することが示された。G2群のステージII患者はG0/G1群のステージII患者に比してOSとDFSに関して有意に予後が不良であり、生存曲線はステージIII患者と同様であった。p53およびMMP-7の発現に基づくG-factorは、ステージII/III胃癌の転帰を予測し、ステージII癌に対する治療選択において有用であると考えられた。

  • New molecular staging with G-factor supplements TNM classification in gastric cancer: a multicenter collaborative research by the Japan Society for Gastroenterological Carcinogenesis G-Project committee Reviewed

    Sawada Tetsuji, Yashiro Masakazu, Sentani Kazuhiro, Oue Naohide, Yasui Wataru, Miyazaki Kohji, Kai Keita, Fushida Sachio, Fujimura Takashi, Ohira Masaichi, Kakeji Yoshihiro, Natsugoe Shoji, Shirabe Ken, Nomura Sachiyo, Shimada Yutaka, Tomita Naohiro, Hirakawa Kosei, Maehara Yoshihiko

    GASTRIC CANCER   18 ( 1 )   119 - 128   2015.01( ISSN:1436-3291

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    DOI: 10.1007/s10120-014-0338-2

    PubMed

  • Epigenetic modulation and repression of miR-200b by cancer-associated fibroblasts contribute to cancer invasion and peritoneal dissemination in gastric cancer Reviewed

    Junji Kurashige, Kosuke Mima, Genta Sawada, Yusuke Takahashi, Hidetoshi Eguchi, Keishi Sugimachi, Masaki Mori, Kazuyoshi Yanagihara, Masakazu Yashiro, Kosei Hirakawa, Hideo Baba, Koshi Mimori

    CARCINOGENESIS   36 ( 1 )   133 - 41   2015.01( ISSN:0143-3334 ( eISSN:1460-2180

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    CAFs induced the hypermethylation of the miR-200b promoter regions and reduced miR-200b expression and there was a negative correlation between miR-200b expression in gastric cancer specimens and alpha-smooth muscle actin expression in the stroma of gastric cancer.Cancer-associated fibroblasts (CAFs) have recently been linked to the invasion and metastasis of gastric cancer. In addition, the microRNA (miR)-200 family plays a central role in the regulation of the epithelial-mesenchymal transition process during cancer metastasis, and aberrant DNA methylation is one of the key mechanisms underlying regulation of the miR-200 family. In this study, we clarified whether epigenetic changes of miR-200b by CAFs stimulate cancer invasion and peritoneal dissemination in gastric cancer. We evaluated the relationship between miR-200b and CAFs using a coculture model. In addition, we established a peritoneal metastasis mouse model and investigated the expression and methylation status of miR-200b. We also investigated the expression and methylation status of miR-200b and CAFs expression in primary gastric cancer samples. CAFs (CAF-37 and CAF-50) contributed to epigenetic changes of miR-200b, reduced miR-200b expression and promoted tumor invasion and migration in NUGC3 and OCUM-2M cells in coculture. In the model mice, epigenetic changes of miR-200b were observed in the inoculated high-frequency peritoneal dissemination cells. In the 173 gastric cancer samples, the low miR-200b expression group demonstrated a significantly poorer prognosis compared with the high miR-200b expression group and was associated with peritoneal metastasis. In addition, downregulation of miR-200b in cancer cells was significantly correlated with alpha-smooth muscle actin expression. Our data provide evidence that CAFs reduce miR-200b expression and promote tumor invasion through epigenetic changes of miR-200b in gastric cancer. Thus, CAFs might be a therapeutic target for inhibition of gastric cancer.

    DOI: 10.1093/carcin/bgu232

    PubMed

  • New molecular staging with G-factor supplements TNM classification in gastric cancer: a multicenter collaborative research by the Japan Society for Gastroenterological Carcinogenesis G-Project committee Reviewed

    Tetsuji Sawada, Masakazu Yashiro, Kazuhiro Sentani, Naohide Oue, Wataru Yasui, Kohji Miyazaki, Keita Kai, Sachio Fushida, Takashi Fujimura, Masaichi Ohira, Yoshihiro Kakeji, Shoji Natsugoe, Ken Shirabe, Sachiyo Nomura, Yutaka Shimada, Naohiro Tomita, Kosei Hirakawa, Yoshihiko Maehara

    GASTRIC CANCER   18 ( 1 )   119 - 28   2015.01( ISSN:1436-3291 ( eISSN:1436-3305

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    The G-Project committee was erected by the Japan Society for Gastroenterological Carcinogenesis with an aim of establishing a new classification scheme based on molecular biological characteristics that would supplement the conventional TNM classification to better predict outcome.
    In a literature search involving 822 articles on gastric cancer, eight molecules including p53, vascular endothelial growth factor (VEGF)-A, VEGF-C, matrix metalloproteinase-7 (MMP-7), human epidermal growth factor receptor 2, Regenerating islet-derived family, member 4, olfactomedin-4 and Claudin-18 were selected as candidates to be included in the new molecular classification scheme named G-factor. A total of 210 cases of gastric cancer who underwent curative R0 resection were registered from four independent facilities. Immunohistochemical staining for the aforementioned molecules was performed for the surgically resected specimens of the 210 cases to investigate the correlation between clinicopathological factors and expression of each molecule.
    No significant correlation was observed between the immunostaining expression of any of the eight factors and postoperative recurrence. However, the expressions of p53 and MMP-7 were significantly correlated with overall survival (OS). When 210 gastric cancer patients were divided into three groups based on the expression of p53 and MMP-7 (G0 group: negative for both p53 and MMP-7, n = 69, G1 group: positive for either p53 or MMP-7, n = 97, G2 group: positive for both of the molecules, n = 44), G2 group demonstrated significantly higher recurrence rate (59 %) compared to 38 % in G0 (p = 0.047). The multivariate regression analysis revealed that G2 group was independently associated with a shorter disease-free survival (DFS) (hazard ratio 1.904, 95 % CI 1.098-3.303; p = 0.022), although the association with OS was not significant. Stage II patients among the G2 group had significantly inferior prognosis both in terms of OS and DFS when compared with those among the G0/G1 group, with survival curves similar to those of Stage III cases.
    G-factor based on the expression of p53 and MMP-7 was found to be a promising factor to predict outcome of Stage II/III gastric cancer, and possibly to help select the treatment for Stage II cancer, thus supplementing the conventional TNM system.

    DOI: 10.1007/s10120-014-0338-2

    PubMed

  • G-factorを加えたTNM分類による胃癌の新規分子ステージング 日本消化器癌発生学会のGプロジェクト委員会による多施設共同研究(New molecular staging with G-factor supplements TNM classification in gastric cancer: a multicenter collaborative research by the Japan Society for Gastroenterological Carcinogenesis G-Project committee) Reviewed

    Sawada Tetsuji, Yashiro Masakazu, Sentani Kazuhiro, Oue Naohide, Yasui Wataru, Miyazaki Kohji, Kai Keita, Fushida Sachio, Fujimura Takashi, Ohira Masaichi, Kakeji Yoshihiro, Natsugoe Shoji, Shirabe Ken, Nomura Sachiyo, Shimada Yutaka, Tomita Naohiro, Hirakawa Kosei, Maehara Yoshihiko

    Gastric Cancer   18 ( 1 )   119 - 128   2015.01( ISSN:1436-3291

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    Publishing type:Research paper (scientific journal)  

    Gプロジェクト委員会では、従来のTNM分類に分子生物学的特性に基づくG-factorを加えた新たな分類スキームを考案している。今回、胃癌に関する論文を検索し、G-factorの候補として8分子を選定した。根治的R0切除術を受けた胃癌患者210例から得られた切除標本を用いて、8分子に対する免疫染色を行い、臨床病理学的因子と各分子の発現との関連について検討した。8分子の免疫染色発現と術後再発の間に有意な相関は観察されなかった。しかし、p53およびマトリックスメタロプロテイナーゼ-7(MMP-7)の発現は全生存(OS)と有意に相関した。p53およびMMP-7の発現に基づいて210例を3群に分けた場合(G0群:両分子ともに陰性、G1群:どちらかが陽性、G2群:両分子ともに陽性)、G2群はG0群に比して有意に高い再発率を示した。多変量解析では、G2群が短い無病生存(DFS)と独立して関連することが示された。G2群のステージII患者はG0/G1群のステージII患者に比してOSとDFSに関して有意に予後が不良であり、生存曲線はステージIII患者と同様であった。p53およびMMP-7の発現に基づくG-factorは、ステージII/III胃癌の転帰を予測し、ステージII癌に対する治療選択において有用であると考えられた。

  • Cronkhite-Canada Syndrome with Complete Remission after Four Months of Prednisolone Therapy and Polypectomy Reviewed

    Namikawa Hiroki, Takemoto Yasuhiko, Kamata Noriko, Yashiro Masakazu, Hirohashi Kazuhiro, Shuto Taichi

    一般社団法人 日本プライマリ・ケア連合学会 Journal of General and Family Medicine   16 ( 4 )   297 - 301   2015( ISSN:2189-6577

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    The etiology of and optimal treatments for Cronkhite-Canada syndrome (CCS) are still undetermined. Fewer than 5% of CCS patients experience complete remission and 15% of CCS patients develop malignancies. Here, we present a case of CCS involving autoimmune disorders, in which rapid diagnosis, rapid commencement of therapy, and complete remission were achieved after 4 months of prednisolone therapy and polypectomy, although biopsy specimens from all residual colonic polyps revealed adenocarcinoma in one polyp 4 months after prednisolone therapy. It is important to identify gastrointestinal or colonic polyps harboring malignant changes and to examine the involvement of autoimmune mechanisms for better outcomes in CCS patients.

    DOI: 10.14442/jgfm.16.4_297

    CiNii Article

  • Two-Surgeon Technique For Liver Transection Using Precoagulation By A Soft-Coagulation System And Ultrasonic Dissection Reviewed

    Yamada Nobuya, Amano Ryosuke, Kimura Kenjiro, Murata Akihiro, Yashiro Masakazu, Tanaka Sayaka, Wakasa Kenichi, Hirakawa Kosei

    HEPATO-GASTROENTEROLOGY   62 ( 138 )   389 - 392   2015( ISSN:0172-6390

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    DOI: 10.5754/hge14950

  • Are gemcitabine sensitivity related molecules useful as predictor of prognosis for patients of unresectable or recurrent biliary tract cancer with gemcitabine treatment alone? Reviewed

    Miura Kotaro, Otani Hiroshi, Yashiro Masakazu, Maeda Kiyoshi, Ohira Masaichi, Hirakawa Kosei, Amano Ryosuke, Murata Akihiro, Nakata Bunzo, Kimura Kenjiro, Yamazoe Sadaaki, Kubo Naoshi, Tanaka Hiroaki, Muguruma Kazuya

    Japanese Society for Molecular Tumor Marker Research, Japan Journal of Molecular Tumor Marker Research   30 ( 0 )   15 - 16   2015

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    DOI: 10.11241/jsmtmr.30.15

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  • Clinicopathological Significance of Autophagy in Gastric Cancer Reviewed

    Masuda Go, Muguruma Kazuya, Ohira Masaichi, Hirakawa Kosei, Yashiro Masakazu, Kitayama Kishu, Kasashima Hiroaki, Kinoshita Haruhito, Fukuoka Tatsunari, Morisaki Tamami, Kubo Naoshi, Tanaka Hiroaki

    Japanese Society for Molecular Tumor Marker Research, Japan Journal of Molecular Tumor Marker Research   31 ( 0 )   70 - 70   2015

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    DOI: 10.11241/jsmtmr.31.70

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  • Clinicopathological meanings of Lysyl Oxidase family in Gastric Carcinoma Reviewed

    Kasashima Hiroaki, Ohira Masaichi, Hirakawa Kosei, Yashiro Masakazu, Masuda Go, Kinoshita Haruhito, Sakurai Katsunobu, Toyokawa Takahiro, Kubo Naoshi, Tanaka Hiroaki, Muguruma Kazuya

    Japanese Society for Molecular Tumor Marker Research, Japan Journal of Molecular Tumor Marker Research   30 ( 0 )   43 - 44   2015

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    DOI: 10.11241/jsmtmr.30.43

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  • Clinical significance of node infiltrating tumor–associated macrophage in gastric cancer Reviewed

    Tauchi Yukie, Toyokawa Takahiro, Amano Ryousuke, Kubo Naoshi, Muguruma Kazuya, Ohtani Hiroshi, Yashiro Masakazu, Maeda Kiyoshi, Ohira Masaichi, Hirakawa Kosei, Tanaka Hiroaki, Sakimura Chie, Tokumoto Mao, Shibutani Masatsune, Yamazoe Sadaaki, Sakurai Katsunobu, Nagahara Hisashi, Kimura Kenjiro

    Japanese Society for Molecular Tumor Marker Research, Japan Journal of Molecular Tumor Marker Research   30 ( 0 )   27 - 28   2015

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    DOI: 10.11241/jsmtmr.30.27

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  • Bone marrow-derived stromal cells are associated with gastric cancer progression Reviewed

    Kasashima Hiroaki, Tanaka Hiroaki, Muguruma Kazuya, Ohira Masaichi, Nakane Takahiko, Hino Masayuki, Hirakawa Kosei, Yashiro Masakazu, Nakamae Hirohisa, Yuichiro Miki, Kitayama Kisyu, Masuda Go, Sakurai Katsunobu, Toyokawa Takahiro, Kubo Naoshi

    Japanese Society for Molecular Tumor Marker Research, Japan Journal of Molecular Tumor Marker Research   31 ( 0 )   71 - 72   2015

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    DOI: 10.11241/jsmtmr.31.71

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  • RBBP6, a predictive prognosis marker in gastric cancer Reviewed

    Morisaki Tamami, Muguruma Kazuya, Ohira Masaichi, Hirakawa Kosei, Yashiro Masakazu, Kasashima Hiroaki, Masuda Go, Kinoshita Haruhito, Sakurai Katsunobu, Toyokawa Takahiro, Kubo Naoshi, Tanaka Hiroaki

    Japanese Society for Molecular Tumor Marker Research, Japan Journal of Molecular Tumor Marker Research   30 ( 0 )   47 - 48   2015

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    DOI: 10.11241/jsmtmr.30.47

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  • Exosomal miRNAs from Peritoneum Lavage Fluid as Potential Prognostic Biomarkers of Peritoneal Metastasis in Gastric Cancer Reviewed

    Motohiko Tokuhisa, Yasushi Ichikawa, Nobuyoshi Kosaka, Takahiro Ochiya, Masakazu Yashiro, Kosei Hirakawa, Takashi Kosaka, Hirochika Makino, Hirotoshi Akiyama, Chikara Kunisaki, Itaru Endo

    PLOS ONE   10 ( 7 )   e0130472   2015( ISSN:1932-6203

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    Peritoneal metastasis is the most frequent type of recurrence in patients with gastric cancer (GC) and is associated with poor prognosis. Peritoneal lavage cytology, used to evaluate the risk of peritoneal metastasis, has low sensitivity. Here, we assessed the diagnostic potential of exosomal miRNA profiles in peritoneal fluid for the prediction of peritoneal dissemination in GC. Total RNA was extracted from exosomes isolated from six gastric malignant ascites (MA) samples, 24 peritoneal lavage fluid (PLF) samples, and culture supernatants (CM) of two human gastric carcinoma cell lines that differ in their potential for peritoneal metastasis. Expression of exosomal miRNAs was evaluated with Agilent Human miRNA microarrays and quantitative reverse transcription polymerase chain reaction (qRT-PCR). The microarray analysis indicated a low variability in the number and signal intensity of miRNAs detected among the samples. In the six MA fluids, miR-21 showed the highest signal intensity. We identified five miRNAs (miR-1225-5p, miR-320c, miR-1202, miR-1207-5p, and miR-4270) with high expression in MA samples, the PLF of serosa-invasive GC, and the CM of a highly metastatic GC cell line; these candidate miRNA species appear to be related to peritoneal dissemination. Differential expression of miR-21, miR-320c, and miR-1225-5p was validated in the PLF of serosa-invasive and non-invasive GC by qRT-PCR and miR-21 and miR-1225-5p were confirmed to be associated with serosal invasion in GC. PLF can be used to profile the expression of exosomal miRNAs. Our findings suggest that miR-21 and miR-1225-5p may serve as biomarkers of peritoneal recurrence after curative GC resection, thus providing a novel approach to early diagnosis of peritoneal dissemination of GC.

    DOI: 10.1371/journal.pone.0130472

    PubMed

  • Are gemcitabine sensitivity related molecules useful as predictor of prognosis for patients of unresectable or recurrent biliary tract cancer with gemcitabine treatment alone? Reviewed

    Miura Kotaro, Amano Ryosuke, Murata Akihiro, Nakata Bunzo, Kimura Kenjiro, Yamazoe Sadaaki, Kubo Naoshi, Tanaka Hiroaki, Muguruma Kazuya, Otani Hiroshi, Yashiro Masakazu, Maeda Kiyoshi, Ohira Masaichi, Hirakawa Kosei

    Japan Journal of Molecular Tumor Marker Research   30 ( 0 )   15 - 16   2015( eISSN:24338575

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    DOI: 10.11241/jsmtmr.30.15

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  • Cronkhite-Canada Syndrome with Complete Remission after Four Months of Prednisolone Therapy and Polypectomy

    Namikawa Hiroki, Takemoto Yasuhiko, Kamata Noriko, Yashiro Masakazu, Hirohashi Kazuhiro, Shuto Taichi

    Journal of General and Family Medicine   16 ( 4 )   297 - 301   2015( ISSN:21896577 ( eISSN:21897948

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    Publishing type:Research paper (scientific journal)  

    The etiology of and optimal treatments for Cronkhite-Canada syndrome (CCS) are still undetermined. Fewer than 5% of CCS patients experience complete remission and 15% of CCS patients develop malignancies. Here, we present a case of CCS involving autoimmune disorders, in which rapid diagnosis, rapid commencement of therapy, and complete remission were achieved after 4 months of prednisolone therapy and polypectomy, although biopsy specimens from all residual colonic polyps revealed adenocarcinoma in one polyp 4 months after prednisolone therapy. It is important to identify gastrointestinal or colonic polyps harboring malignant changes and to examine the involvement of autoimmune mechanisms for better outcomes in CCS patients.

    DOI: 10.14442/jgfm.16.4_297

    CiNii Article

  • Clinicopathological Significance of Autophagy in Gastric Cancer Reviewed

    Masuda Go, Yashiro Masakazu, Kitayama Kishu, Kasashima Hiroaki, Kinoshita Haruhito, Fukuoka Tatsunari, Morisaki Tamami, Kubo Naoshi, Tanaka Hiroaki, Muguruma Kazuya, Ohira Masaichi, Hirakawa Kosei

    Japan Journal of Molecular Tumor Marker Research   31 ( 0 )   70 - 70   2015( eISSN:24338575

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    DOI: 10.11241/jsmtmr.31.70

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  • Clinicopathological meanings of Lysyl Oxidase family in Gastric Carcinoma Reviewed

    Kasashima Hiroaki, Yashiro Masakazu, Masuda Go, Kinoshita Haruhito, Sakurai Katsunobu, Toyokawa Takahiro, Kubo Naoshi, Tanaka Hiroaki, Muguruma Kazuya, Ohira Masaichi, Hirakawa Kosei

    Japan Journal of Molecular Tumor Marker Research   30 ( 0 )   43 - 44   2015( eISSN:24338575

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    DOI: 10.11241/jsmtmr.30.43

    CiNii Article

  • Clinical significance of node infiltrating tumor–associated macrophage in gastric cancer Reviewed

    Tauchi Yukie, Tanaka Hiroaki, Sakimura Chie, Tokumoto Mao, Shibutani Masatsune, Yamazoe Sadaaki, Sakurai Katsunobu, Nagahara Hisashi, Kimura Kenjiro, Toyokawa Takahiro, Amano Ryousuke, Kubo Naoshi, Muguruma Kazuya, Ohtani Hiroshi, Yashiro Masakazu, Maeda Kiyoshi, Ohira Masaichi, Hirakawa Kosei

    Japan Journal of Molecular Tumor Marker Research   30 ( 0 )   27 - 28   2015( eISSN:24338575

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    DOI: 10.11241/jsmtmr.30.27

    CiNii Article

  • Bone marrow-derived stromal cells are associated with gastric cancer progression Reviewed

    Kasashima Hiroaki, Yashiro Masakazu, Nakamae Hirohisa, Yuichiro Miki, Kitayama Kisyu, Masuda Go, Sakurai Katsunobu, Toyokawa Takahiro, Kubo Naoshi, Tanaka Hiroaki, Muguruma Kazuya, Ohira Masaichi, Nakane Takahiko, Hino Masayuki, Hirakawa Kosei

    Japan Journal of Molecular Tumor Marker Research   31 ( 0 )   71 - 72   2015( eISSN:24338575

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    DOI: 10.11241/jsmtmr.31.71

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    Other URL: http://search.jamas.or.jp/link/ui/2016258151

  • RBBP6, a predictive prognosis marker in gastric cancer Reviewed

    Morisaki Tamami, Yashiro Masakazu, Kasashima Hiroaki, Masuda Go, Kinoshita Haruhito, Sakurai Katsunobu, Toyokawa Takahiro, Kubo Naoshi, Tanaka Hiroaki, Muguruma Kazuya, Ohira Masaichi, Hirakawa Kosei

    Japan Journal of Molecular Tumor Marker Research   30 ( 0 )   47 - 48   2015( eISSN:24338575

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    DOI: 10.11241/jsmtmr.30.47

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  • MUC1 Protein Induces Urokinase-type Plasminogen Activator (uPA) by Forming a Complex with NF-kappa B p65 Transcription Factor and Binding to the uPA Promoter, Leading to Enhanced Invasiveness of Cancer Cells Reviewed

    Mori Yugo, Akita Kaoru, Tanida Shuhei, Ishida Akiko, Toda Munetoyo, Inoue Mizue, Yashiro Masakazu, Sawada Tetsuji, Hirakawa Kosei, Nakada Hiroshi

    JOURNAL OF BIOLOGICAL CHEMISTRY   289 ( 51 )   35193 - 35204   2014.12( ISSN:0021-9258

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    DOI: 10.1074/jbc.M114.586461

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  • MUC1 Protein Induces Urokinase-type Plasminogen Activator (uPA) by Forming a Complex with NF-kappa B p65 Transcription Factor and Binding to the uPA Promoter, Leading to Enhanced Invasiveness of Cancer Cells Reviewed

    Yugo Mori, Kaoru Akita, Shuhei Tanida, Akiko Ishida, Munetoyo Toda, Mizue Inoue, Masakazu Yashiro, Tetsuji Sawada, Kosei Hirakawa, Hiroshi Nakada

    JOURNAL OF BIOLOGICAL CHEMISTRY   289 ( 51 )   35193 - 204   2014.12( ISSN:0021-9258 ( eISSN:1083-351X

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    Mucin 1 (MUC1) is overexpressed in various human malignant tumors and its expression is correlated with a poor prognosis. MUC1 engages in signal transduction by interacting with receptors for growth and differentiation factors, which contributes to the growth and survival of cancer cells. However, the mechanism by which MUC1 promotes cancer cell invasion remains unclear. Microarray analysis revealed that expression of urokinase-type plasminogen activator (uPA) was elevated in MUC1-overexpressing cells. Furthermore, up- and down-modulation of MUC1 expression was clearly correlated with the change of uPA expression. An immunochemical study showed that the distribution of uPA coincided with that of MUC1 in various human cancer tissues. The MUC1 C-terminal domain (MUC1-CD) was associated with nuclear factor-B (NF-B) p65 in MUC1-expressing cells. Chromatin immunoprecipitation (ChIP) assays demonstrated that MUC1-CD existed with NF-B p65 on the uPA promoter. Luciferase assays indicated that the uPA transcriptional activity was correlated with the level of MUC1 expression and that this MUC1-enhancing effect on the uPA transcription was abolished by introduction of mutations into the NF-B binding sites on the uPA promoter. These results indicate that formation of the MUC1-CD and NF-B p65 complex enhanced nuclear translocation of NF-B p65 and subsequent occupancy of NF-B binding region on the uPA promoter, leading to elevated transcription of uPA. We also demonstrated that uPA induced by MUC1 enhanced the matrix metalloproteinase (MMP)-2 and -9 activities, and consequently promoted cancer cell invasion. Thus, a MUC1 co-operating NF-B signaling pathway plays a critical role in cancer cell invasion in MUC1-expressing cells.

    DOI: 10.1074/jbc.M114.586461

    PubMed

  • Lysyl oxidase-like 2 (LOXL2) from stromal fibroblasts stimulates the progression of gastric cancer Reviewed

    Kasashima Hiroaki, Yashiro Masakazu, Kinoshita Haruhito, Fukuoka Tatsunari, Morisaki Tamami, Masuda Go, Sakurai Katsunobu, Kubo Naoshi, Ohira Masaichi, Hirakawa Kosei

    CANCER LETTERS   354 ( 2 )   438 - 446   2014.11( ISSN:0304-3835

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    DOI: 10.1016/j.canlet.2014.08.014

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  • Ulcerative colitis-associated colorectal cancer Reviewed

    Yashiro Masakazu

    WORLD JOURNAL OF GASTROENTEROLOGY   20 ( 44 )   16389 - 16397   2014.11( ISSN:1007-9327

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    DOI: 10.3748/wjg.v20.i44.16389

    PubMed

  • Lysyl oxidase-like 2 (LOXL2) from stromal fibroblasts stimulates the progression of gastric cancer Reviewed

    Hiroaki Kasashima, Masakazu Yashiro, Haruhito Kinoshita, Tatsunari Fukuoka, Tamami Morisaki, Go Masuda, Katsunobu Sakurai, Naoshi Kubo, Masaichi Ohira, Kosei Hirakawa

    CANCER LETTERS   354 ( 2 )   438 - 46   2014.11( ISSN:0304-3835 ( eISSN:1872-7980

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    The aim of this study was to clarify the role of fibroblast-derived Lysyl oxidase-like 2 (LOXL2) in the development of gastric cancer. The correlation between the clinicopathological features of 548 primary gastric carcinomas and LOXL2 expression in stromal cells was examined by immunohistochemistry. Two gastric cancer cell lines, OCUM-12 and NUGC-3, and cancer-associated fibroblasts (CAFs) were used in this in vitro study. The effect of fibroblast-derived LOXL2 on the motility of gastric cancer cells was analyzed by using a wound-healing assay, a double-chamber invasion assay, and western blot. LOXL2 expression in stromal cells was significantly associated with tumor invasion depth, lymph node metastasis, lymphatic invasion, venous invasion, and peritoneal dissemination. Multivariable logistic regression analysis revealed that LOXL2 expression in stromal cells could be an independent predictive parameter for the overall survival of patients. CAFs significantly stimulated the migration and invasion of OCUM-12 and NUGC-3 cells. This motility-stimulating ability of CAFs was inhibited by LOXL2 siRNA. Western blot analysis indicated that phosphorylation of focal adhesion kinase (FAK) in cancer cells was increased by the conditioned medium from CAFs, and was decreased by the conditioned medium from LOXL2 siRNA-treated CAFs. LOXL2 expression in stromal cells may be a useful prognostic factor for patients with gastric cancer. Fibroblast-derived LOXL2 may stimulate the motility of gastric cancer cells. (C) 2014 Elsevier Ireland Ltd. All rights reserved.

    DOI: 10.1016/j.canlet.2014.08.014

    PubMed

  • Ulcerative colitis-associated colorectal cancer Reviewed

    Masakazu Yashiro

    WORLD JOURNAL OF GASTROENTEROLOGY   20 ( 44 )   16389 - 97   2014.11( ISSN:1007-9327 ( eISSN:2219-2840

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    The association between ulcerative colitis (UC) and colorectal cancer (CRC) has been acknowledged. One of the most serious and life threatening consequences of UC is the development of CRC (UC-CRC). UC-CRC patients are younger, more frequently have multiple cancerous lesions, and histologically show mucinous or signet ring cell carcinomas. The risk of CRC begins to increase 8 or 10 years after the diagnosis of UC. Risk factors for CRC with UC patients include young age at diagnosis, longer duration, greater anatomical extent of colonic involvement, the degree of inflammation, family history of CRC, and presence of primary sclerosing cholangitis. CRC on the ground of UC develop from non-dysplastic mucosa to indefinite dysplasia, low-grade dysplasia, high-grade dysplasia and finally to invasive adenocarcinoma. Colonoscopy surveillance programs are recommended to reduce the risk of CRC and mortality in UC. Genetic alterations might play a role in the development of UC-CRC. 5-aminosalicylates might represent a favorable therapeutic option for chemoprevention of CRC. (C) 2014 Baishideng Publishing Group Inc. All rights reserved.

    DOI: 10.3748/wjg.v20.i44.16389

    PubMed

  • Early gastric cancer with suspected brain metastasis arising eight years after curative resection: a case report. Reviewed

    Sakurai K, Muguruma K, Murata A, Toyokawa T, Amano R, Kubo N, Tanaka H, Yashiro M, Maeda K, Ohira M, Hirakawa K

    BMC research notes   7   818   2014.11

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    DOI: 10.1186/1756-0500-7-818

    PubMed

  • Early gastric cancer with suspected brain metastasis arising eight years after curative resection: A case report Reviewed

    Katsunobu Sakurai, Kazuya Muguruma, Akihiro Murata, Takahiro Toyokawa, Ryosuke Amano, Naoshi Kubo, Hiroaki Tanaka, Masakazu Yashiro, Kiyoshi Maeda, Masaichi Ohira, Kosei Hirakawa

    BMC Research Notes   7 ( 1 )   818   2014.11( ISSN:1756-0500

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    Background: Brain metastasis from gastric cancer is fairly uncommon and prognosis is dismal. We report a case of early gastric cancer with brain metastasis arising 8 years after gastrectomy. Case presentation: A 78-year-old Japanese female presented to our hospital complaining of dizziness, 8 years after undergoing gastrectomy for gastric cancer. Histopathological type of the tumor was well-differentiated adenocarcinoma. Final TNM classification was T1b(sm1)N0M0, and pathological stage was IA. Further examination revealed a metastatic tumor in the cerebellum and multiple liver metastases. The brain metastasis was treated using radiotherapy and steroid. Systemic treatment for liver metastases was performed using the oral fluoropyrimidine drug S-1. Neurological symptoms decreased, enabling the patient to be discharged from hospital. However, chemotherapy was discontinued due to loss of appetite and general fatigue. She died 5 months after the diagnosis of brain metastasis due to progressive disease. Conclusions: Cases of brain metastasis arising 8 years after gastrectomy for early gastric cancer have rarely reported. Aggressive treatment for brain metastases may be effective for improvement of the damage to neurological function and quality of life.

    DOI: 10.1186/1756-0500-7-818

    PubMed

  • Comparative Proteomics Analysis of Gastric Cancer Stem Cells Reviewed

    Morisaki Tamami, Yashiro Masakazu, Kakehashi Anna, Inagaki Azusa, Kinoshita Haruhito, Fukuoka Tatsunari, Kasashima Hiroaki, Masuda Go, Sakurai Katsunobu, Kubo Naoshi, Muguruma Kazuya, Ohira Masaichi, Wanibuchi Hideki, Hirakawa Kosei

    PLOS ONE   9 ( 11 )   e110736   2014.11( ISSN:1932-6203

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    DOI: 10.1371/journal.pone.0110736

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  • Effect of recombinant human soluble thrombomodulin in patients with solid carcinoma with DIC Reviewed

    Yuka Asano, Shinichiro Kashiwagi, Masatsune Shibutani, Sadaaki Yamazoe, Satoru Noda, Katsunobu Sakurai, Hisashi Nagahara, Kenjiro Kimura, Hidemi Kawajiri, Takahiro Toyokawa, Ryosuke Amano, Naoshi Kubo, Hiroaki Tanaka, Kazuya Muguruma, Hiroshi Ohtani, Tsutomu Takashima, Masakazu Yashiro, Naoyoshi Onoda, Kiyoshi Maeda, Masaichi Ohira, Kosei Hirakawa

    Japanese Journal of Cancer and Chemotherapy   41 ( 12 )   2503 - 2505   2014.11( ISSN:0385-0684

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    There are only a few reports in the literature about the effect of recombinant human soluble thrombomodulin (rTM) in Patients with solid carcinoma with disseminated intravascular coagulation (DIC). A retrospective study of 40 patients with solid carcinoma with DIC was performed between February 2009 and April 2013. The withdrawal rate was 32.5% (13/40 Patients) and the 28-day survival rate was 40.0% (16/40 patients). Patients with successful withdrawal of DIC had significantly better outcomes (p&lt
    0.001). Therapy with rTM is one of the treatment options for patients with solid carcinoma with DIC.

    PubMed

  • A case of lymph node recurrence occurring nine years after surgery for sigmoid colon cancer Reviewed

    Shingo Togano, Masatsune Shibutani, Kiyoshi Maeda, Masakazu Yashiro, Hisashi Nagahara, Hiroshi Ohtani, Katsunobu Sakurai, Sadaaki Yamazoe, Kenjiro Kimura, Takahiro Toyokawa, Ryosuke Amano, Naoshi Kubo, Hiroaki Tanaka, Kazuya Muguruma, Masaichi Ohira, Kosei Hirakawa

    Japanese Journal of Cancer and Chemotherapy   41 ( 12 )   1614 - 1616   2014.11( ISSN:0385-0684

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    A 64-year-old man underwent sigmoidectomy for sigmoid colon cancer 9 years ago. We attempted to discontinue surveillance, as the postoperative course was event free for 5 years
    however, we continued the follow-up on the patient's request. Nine years after the operation, elevation of the serum carcinoembryonic antigen (CEA) level was detected, and positron emission tomography-computed tomography (PET-CT) showed a 35-mm mass with an abnormal signal (SUVmax 18.6 Bq/mL). We performed an abdominal CT and magnetic resonance imaging and found the mass invading the sigmoid colon. We suspected lymph node recurrence of the sigmoid colon cancer and considered curative surgery to be appropriate as there were no other signs of recurrence. We therefore excised the tumor by sigmoidectomy. A histopathological examination revealed metastatic adenocarcinoma in the lymph node. One year after the second operation, there was no evidence of recurrence on imaging and the levels of tumor markers were within the normal limits. Few reports have documented recurrence over 5 years after surgery. We herein describe our case and report the characteristics of a recurrent lesion and also suggest a protocol for surveillance, taking into consideration the previous literature.

    PubMed

  • Stage IV small cell esophageal carcinoma that responded to various chemotherapeutic regimens with relative longevity - A case report Reviewed

    Yoshihito Yamakoshi, Naoshi Kubo, Masaichi Ohira, Katsunobu Sakurai, Takahiro Toyokawa, Masatsune Shibutani, Sadaaki Yamazoe, Hisashi Nagahara, Kenjiro Kimura, Ryosuke Amano, Hiroaki Tanaka, Kazuya Muguruma, Hiroshi Ohtani, Masakazu Yashiro, Kiyoshi Maeda, Kosei Hirakawa

    Japanese Journal of Cancer and Chemotherapy   41 ( 12 )   2021 - 2023   2014.11( ISSN:0385-0684

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    Small cell carcinoma of the esophagus is reported to be both rare and aggressive, and is commonly associated with a short Post-diagnosis survival period. We report a case of Stage IV small cell carcinoma of the esophagus involving a relatively long survival period of 2 years. The patient was a 70-year-old man with a chief complaint of epigastric discomfort. Upper gastrointestinal endoscopy by a local physician showed a protruding tumor at the mid-thoracic esophagus. Tumor biopsy revealed small cell carcinoma. Chest-abdominal computed tomography revealed multiple liver metastases, and swelling of a number of regional lymph nodes. The diagnosis was cT3N4M1, cStage IVb esophageal small cell carcinoma. According to the regimen used for lung small cell carcinoma, we administered CDDP/CPT-11. After administration of four courses, the primary lesion, liver metastases, and lymph node metastases significantly reduced, indicating a partial response. However, after completion of eight courses, liver metastasis and lymph node swelling recurred. The patient subsequently received other therapeutic regimens such as CBDCA/VP-16, AMR, NGT, and CDGP/5-FU. However, the tumor gradually progressed, and the patient died approximately 2 years after the first treatment.

    PubMed

  • [A case of lymph node recurrence occurring nine years after surgery for sigmoid colon cancer]. Reviewed

    Togano S, Shibutani M, Maeda K, Yashiro M, Nagahara H, Ohtani H, Sakurai K, Yamazoe S, Kimura K, Toyokawa T, Amano R, Kubo N, Tanaka H, Muguruma K, Ohira M, Hirakawa K

    Gan to kagaku ryoho. Cancer & chemotherapy   41 ( 12 )   1614 - 6   2014.11( ISSN:0385-0684

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    PubMed

  • [Stage IV small cell esophageal carcinoma that responded to various chemotherapeutic regimens with relative longevity - a case report]. Reviewed

    Yamakoshi Y, Kubo N, Ohira M, Sakurai K, Toyokawa T, Shibutani M, Yamazoe S, Nagahara H, Kimura K, Amano R, Tanaka H, Muguruma K, Ohtani H, Yashiro M, Maeda K, Hirakawa K

    Gan to kagaku ryoho. Cancer & chemotherapy   41 ( 12 )   2021 - 3   2014.11( ISSN:0385-0684

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    PubMed

  • [Effect of recombinant human soluble thrombomodulin in patients with solid carcinoma with DIC]. Reviewed

    Asano Y, Kashiwagi S, Shibutani M, Yamazoe S, Noda S, Sakurai K, Nagahara H, Kimura K, Kawajiri H, Toyokawa T, Amano R, Kubo N, Tanaka H, Muguruma K, Ohtani H, Takashima T, Yashiro M, Onoda N, Maeda K, Ohira M, Hirakawa K

    Gan to kagaku ryoho. Cancer & chemotherapy   41 ( 12 )   2503 - 5   2014.11( ISSN:0385-0684

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    PubMed

  • Pazopanib, a Novel Multitargeted Kinase Inhibitor, Shows Potent In Vitro Antitumor Activity in Gastric Cancer Cell Lines with FGFR2 Amplification Reviewed

    Kim Seung Tae, Jang Hye-Lim, Lee Su Jin, Lee Jeeyun, Choi Yoon-La, Kim Kyoung-Mee, Cho Jeonghee, Park Se Hoon, Park Young Suk, Lim Ho Yeong, Yashiro Masakazu, Kang Won Ki, Park Joon Oh

    MOLECULAR CANCER THERAPEUTICS   13 ( 11 )   2527 - 2536   2014.11( ISSN:1535-7163

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    DOI: 10.1158/1535-7163.MCT-14-0255

    PubMed

  • 固形癌DICに対する遺伝子組換えヒトトロンボモジュリン製剤の臨床的検討 Reviewed

    浅野 有香, 柏木 伸一郎, 渋谷 雅常, 山添 定明, 野田 諭, 櫻井 克宣, 永原 央, 木村 健二郎, 川尻 成美, 豊川 貴弘, 天野 良亮, 久保 尚士, 田中 浩明, 六車 一哉, 大谷 博, 高島 勉, 八代 正和, 小野田 尚佳, 前田 清, 大平 雅一, 平川 弘聖

    (株)癌と化学療法社 癌と化学療法   41 ( 12 )   2503 - 2505   2014.11( ISSN:0385-0684

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    背景:固形癌患者は凝固活性亢進状態にあり、播種性血管内凝固症候群(DIC)の基礎疾患として重要である。一方で、新たなDIC治療薬として注目されている遺伝子組換えヒトトロンボモジュリン製剤(rTM)は、感染に伴うDICでの有用性は散見されるが、担癌患者における有用性の証明は十分とはいえない。今回、固形癌担癌患者のDICを対象とし、rTMの有用性・安全性について検討を行った。対象と方法:固形癌担癌患者のDICに対してrTMを投与した40例を対象とし、rTM製剤の有用性・安全性を検討した。結果:固形癌担癌患者40例のうち、消化器系17例(42.5%)、泌尿器系が15例(37.5%)などであった。13例(32.5%)がDIC離脱に成功しており、離脱までに要した日数の中央値は3.0日であった。有害事象は4例(10.0%)に出血傾向などが認められた。臨床因子との検討では、出血症状を有する症例は有意に離脱困難であった(p=0.043)。また、DIC離脱に成功した症例は有意に良好な転帰であった(p<0.001)。結語:固形癌担癌患者のDICに対し、rTM療法は治療選択肢の一つになると考えられた。(著者抄録)

  • Significance of Ductal Region in Anaplastic Pancreatic Cancer Reviewed

    Miura K., Kimura K., Amano R., Yamazoe S., Ohira G., Nishio K., Shibutani M., Sakurai K., Nagahara H., Toyokawa T., Kubo N., Tanaka H., Muguruma K., Otani H., Yashiro M., Maeda K., Ohira M., Hirakawa K.

    PANCREAS   43 ( 8 )   1391 - 1391   2014.11( ISSN:0885-3177

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  • 術後9年目に局所リンパ節再発を来したS状結腸癌の1例 Reviewed

    栂野 真吾, 渋谷 雅常, 前田 清, 八代 正和, 永原 央, 大谷 博, 櫻井 克宣, 山添 定明, 木村 健二郎, 豊川 貴弘, 天野 良亮, 久保 尚士, 田中 浩明, 六車 一哉, 大平 雅一, 平川 弘聖

    (株)癌と化学療法社 癌と化学療法   41 ( 12 )   1614 - 1616   2014.11( ISSN:0385-0684

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    症例は64歳、男性。55歳時にS状結腸癌に対してS状結腸切除術を施行した。術後5年間無再発で経過し、サーベイランス終了を予定していたが本人の希望で継続していた。術後9年目、CEA値の上昇を認めPET-CT検査を施行したところ、骨盤内に異常集積を伴う長径35mm大の腫瘍を認めた。腹骨盤CTおよびMRI検査の結果、S状結腸への浸潤を伴うリンパ節再発が疑われた。その他の部位に再発を示唆する病変を認めず、根治切除が可能と判断し、腫瘍摘出およびS状結腸切除を行った。病理検査の結果、リンパ節再発と診断された。現在、術後1年が経過するが無再発生存中である。術後5年以降の遠隔期再発についての報告は散見されるが、その特徴やサーベイランス法について文献的考察を加えて報告する。(著者抄録)

  • 様々な化学療法により長期生存したStage IVb食道小細胞癌の1例 Reviewed

    山越 義仁, 久保 尚士, 大平 雅一, 櫻井 克宣, 豊川 貴弘, 渋谷 雅常, 山添 定明, 永原 央, 木村 健二郎, 天野 良亮, 田中 浩明, 六車 一哉, 大谷 博, 八代 正和, 前田 清, 平川 弘聖

    (株)癌と化学療法社 癌と化学療法   41 ( 12 )   2021 - 2023   2014.11( ISSN:0385-0684

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    食道小細胞癌は、非常に予後が悪く、なかでもStage IVの長期生存例の報告は少ない。今回われわれは、種々の化学療法により約2年と比較的長期に生存したStage IVb食道小細胞癌の1例を経験したので報告する。症例は70歳、男性。主訴は心窩部不快感。上部消化管内視鏡検査で胸部中部食道に1型病変を認め、生検にて小細胞癌と診断された。胸腹部CT検査で多発肝転移、遠隔リンパ節転移を認め、食道小細胞癌cT3N4M1、cStage IVbと診断した。肺小細胞癌に準じてCDDP/CPT-11療法を開始。4コース施行後、腫瘍は著明に縮小し、PRと判定した。しかし、8コース施行後、腫瘍の再増大を認めたため、CBDCA/VP-16、AMR、NGT、CDGP/5-FUを順次投与したが腫瘍はしだいに増大し、治療開始から約2年後に永眠された。(著者抄録)

  • [A case of lymph node recurrence occurring nine years after surgery for sigmoid colon cancer]. Reviewed

    Togano S, Shibutani M, Maeda K, Yashiro M, Nagahara H, Ohtani H, Sakurai K, Yamazoe S, Kimura K, Toyokawa T, Amano R, Kubo N, Tanaka H, Muguruma K, Ohira M, Hirakawa K

    Gan to kagaku ryoho. Cancer & chemotherapy   41 ( 12 )   1614 - 6   2014.11( ISSN:0385-0684

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    PubMed

  • [Stage IV small cell esophageal carcinoma that responded to various chemotherapeutic regimens with relative longevity - a case report]. Reviewed

    Yamakoshi Y, Kubo N, Ohira M, Sakurai K, Toyokawa T, Shibutani M, Yamazoe S, Nagahara H, Kimura K, Amano R, Tanaka H, Muguruma K, Ohtani H, Yashiro M, Maeda K, Hirakawa K

    Gan to kagaku ryoho. Cancer & chemotherapy   41 ( 12 )   2021 - 3   2014.11( ISSN:0385-0684

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    PubMed

  • Pazopanib, a Novel Multitargeted Kinase Inhibitor, Shows Potent In Vitro Antitumor Activity in Gastric Cancer Cell Lines with FGFR2 Amplification Reviewed

    Seung Tae Kim, Hye-Lim Jang, Su Jin Lee, Jeeyun Lee, Yoon-La Choi, Kyoung-Mee Kim, Jeonghee Cho, Se Hoon Park, Young Suk Park, Ho Yeong Lim, Masakazu Yashiro, Won Ki Kang, Joon Oh Park

    MOLECULAR CANCER THERAPEUTICS   13 ( 11 )   2527 - 36   2014.11( ISSN:1535-7163 ( eISSN:1538-8514

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    Pazopanib is an orally bioavailable, ATP-competitive, multitargeted tyrosine kinase inhibitor mainly targeting VEGFR2 and PDGFR tyrosine kinases, but the biologic sequences of pazopanib activities beyond antiangiogenesis are poorly defined. We used a panel of 38 gastric cancer cell lines to test the efficacy of pazopanib. In a growth inhibition assay, genomic changes indicated that pazopanib had differential effects on cell growth. Treatment of the KATO-III, OCUM-2M, SNU-16, and HSC-39 gastric cancer cell lines harboring FGFR2 amplification with pazopanib resulted in marked decreases of cell survival with IC50 in ranges of 0.1 to 2.0 mu mol/L, whereas the same treatment of those cell lines without FGFR2 amplification had no growth-inhibitory effects. In the ectopic FGFR2-expressing model, treatment with the indicated concentrations of pazopanib significantly inhibited cell growth and colony formation by FGFR2-expressing NIH 3T3 cells with wild-type (WT) FGFR2 and mutant FGFR2 (S252W). Pazopanib also selectively suppressed constitutive FGFR2 signaling and phosphorylation of downstream effectors. In cell-cycle analysis, FGFR2-amplified cells underwent cell-cycle arrest at the G(1)-S phase after pazopanib treatment, whereas there were no significant effects on cell-cycle progression in cells without FGFR2 amplification treated with pazopanib. In addition, pazopanib increased a substantial fraction of sub-G(1) only in FGFR2-amplified cells. These findings show that the activation of FGFR2 signaling by amplification may be a critical mediator of cell proliferation in a small subset of gastric cancer patients and that pazopanib may provide genotype-correlated clinical benefits beyond the setting of highly vascular tumors. (C) 2014 AACR.

    DOI: 10.1158/1535-7163.MCT-14-0255

    PubMed

  • 固形癌DICに対する遺伝子組換えヒトトロンボモジュリン製剤の臨床的検討 Reviewed

    浅野 有香, 柏木 伸一郎, 渋谷 雅常, 山添 定明, 野田 諭, 櫻井 克宣, 永原 央, 木村 健二郎, 川尻 成美, 豊川 貴弘, 天野 良亮, 久保 尚士, 田中 浩明, 六車 一哉, 大谷 博, 高島 勉, 八代 正和, 小野田 尚佳, 前田 清, 大平 雅一, 平川 弘聖

    癌と化学療法   41 ( 12 )   2503 - 2505   2014.11( ISSN:0385-0684

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    背景:固形癌患者は凝固活性亢進状態にあり、播種性血管内凝固症候群(DIC)の基礎疾患として重要である。一方で、新たなDIC治療薬として注目されている遺伝子組換えヒトトロンボモジュリン製剤(rTM)は、感染に伴うDICでの有用性は散見されるが、担癌患者における有用性の証明は十分とはいえない。今回、固形癌担癌患者のDICを対象とし、rTMの有用性・安全性について検討を行った。対象と方法:固形癌担癌患者のDICに対してrTMを投与した40例を対象とし、rTM製剤の有用性・安全性を検討した。結果:固形癌担癌患者40例のうち、消化器系17例(42.5%)、泌尿器系が15例(37.5%)などであった。13例(32.5%)がDIC離脱に成功しており、離脱までに要した日数の中央値は3.0日であった。有害事象は4例(10.0%)に出血傾向などが認められた。臨床因子との検討では、出血症状を有する症例は有意に離脱困難であった(p=0.043)。また、DIC離脱に成功した症例は有意に良好な転帰であった(p<0.001)。結語:固形癌担癌患者のDICに対し、rTM療法は治療選択肢の一つになると考えられた。(著者抄録)

  • 術後9年目に局所リンパ節再発を来したS状結腸癌の1例 Reviewed

    栂野 真吾, 渋谷 雅常, 前田 清, 八代 正和, 永原 央, 大谷 博, 櫻井 克宣, 山添 定明, 木村 健二郎, 豊川 貴弘, 天野 良亮, 久保 尚士, 田中 浩明, 六車 一哉, 大平 雅一, 平川 弘聖

    癌と化学療法   41 ( 12 )   1614 - 1616   2014.11( ISSN:0385-0684

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    症例は64歳、男性。55歳時にS状結腸癌に対してS状結腸切除術を施行した。術後5年間無再発で経過し、サーベイランス終了を予定していたが本人の希望で継続していた。術後9年目、CEA値の上昇を認めPET-CT検査を施行したところ、骨盤内に異常集積を伴う長径35mm大の腫瘍を認めた。腹骨盤CTおよびMRI検査の結果、S状結腸への浸潤を伴うリンパ節再発が疑われた。その他の部位に再発を示唆する病変を認めず、根治切除が可能と判断し、腫瘍摘出およびS状結腸切除を行った。病理検査の結果、リンパ節再発と診断された。現在、術後1年が経過するが無再発生存中である。術後5年以降の遠隔期再発についての報告は散見されるが、その特徴やサーベイランス法について文献的考察を加えて報告する。(著者抄録)

  • 様々な化学療法により長期生存したStage IVb食道小細胞癌の1例 Reviewed

    山越 義仁, 久保 尚士, 大平 雅一, 櫻井 克宣, 豊川 貴弘, 渋谷 雅常, 山添 定明, 永原 央, 木村 健二郎, 天野 良亮, 田中 浩明, 六車 一哉, 大谷 博, 八代 正和, 前田 清, 平川 弘聖

    癌と化学療法   41 ( 12 )   2021 - 2023   2014.11( ISSN:0385-0684

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    食道小細胞癌は、非常に予後が悪く、なかでもStage IVの長期生存例の報告は少ない。今回われわれは、種々の化学療法により約2年と比較的長期に生存したStage IVb食道小細胞癌の1例を経験したので報告する。症例は70歳、男性。主訴は心窩部不快感。上部消化管内視鏡検査で胸部中部食道に1型病変を認め、生検にて小細胞癌と診断された。胸腹部CT検査で多発肝転移、遠隔リンパ節転移を認め、食道小細胞癌cT3N4M1、cStage IVbと診断した。肺小細胞癌に準じてCDDP/CPT-11療法を開始。4コース施行後、腫瘍は著明に縮小し、PRと判定した。しかし、8コース施行後、腫瘍の再増大を認めたため、CBDCA/VP-16、AMR、NGT、CDGP/5-FUを順次投与したが腫瘍はしだいに増大し、治療開始から約2年後に永眠された。(著者抄録)

  • Rho/ROCK signaling in motility and metastasis of gastric cancer Reviewed

    Matsuoka Tasuku, Yashiro Masakazu

    WORLD JOURNAL OF GASTROENTEROLOGY   20 ( 38 )   13756 - 13766   2014.10( ISSN:1007-9327

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    DOI: 10.3748/wjg.v20.i38.13756

    PubMed

  • Rho/ROCK signaling in motility and metastasis of gastric cancer Reviewed

    Tasuku Matsuoka, Masakazu Yashiro

    WORLD JOURNAL OF GASTROENTEROLOGY   20 ( 38 )   13756 - 66   2014.10( ISSN:1007-9327 ( eISSN:2219-2840

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    Gastric cancer is one of the most frequent and lethal malignancies worldwide because of high frequency of metastasis. Tumor cell motility and invasion play fundamental roles in cancer metastasis. Recent studies have revealed that the Rho/Rho-associated protein kinases (ROCK) pathway plays a critical role in the regulation of cancer cell motility and invasion. In addition, the Rho/ROCK pathway plays important roles in invasion and metastasis on the basis of its predominant function of cell cytoskeletal regulation in gastric cancer. According to the current understanding of tumor motility, there are two modes of tumor cell movement: mesenchymal and amoeboid. In addition, cancer cell movement can be interchangeable between the mesenchymal and amoeboid movements under certain conditions. Control of cell motility through the actin cytoskeleton creates the potential for regulating tumor cell metastasis. In this review we discuss Rho GTPases and ROCK signaling and describe the mechanisms of Rho/ROCK activity with regard to motility and metastasis in gastric cancer. In addition, we provide an insight of the therapeutic potential of targeting the Rho/ROCK pathway. (C) 2014 Baishideng Publishing Group Inc. All rights reserved.

    DOI: 10.3748/wjg.v20.i38.13756

    PubMed

  • Effect of cancer associated fibroblast on gastric cancer cells under hypoxia Reviewed

    Kinoshita Haruhito, Yashiro Masakazu, Masuda Go, Kasashima Hiroaki, Morisaki Tamami, Fukuoka Tatsunari, Shibutani Masatune, Yamazoe Sadaaki, Sakurai Katsunobu, Nagahara Hisashi, Kimura Kenjiro, Toyokawa Takahiro, Amano Ryosuke, Kubo Naoshi, Tanaka Hiroaki, Muguruma Kazuya, Otani Hiroshi, Maeda Kiyoshi, Ohira Masaichi, Hirakawa Kosei

    CANCER RESEARCH   74 ( 19 )   2014.10( ISSN:0008-5472

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    DOI: 10.1158/1538-7445.AM2014-3612

  • Tumor budding and E-cadherin expression are useful predictors of nodal involvement in T1 esophageal squamous cell carcinoma Reviewed

    Kubo Naoshi, Ohira Masaichi, Sakurai Katsunobu, Toyokawa Takahiro, Tanaka Hiroaki, Muguruma Kazuya, Yashiro Masakazu, Maeda Kiyoshi, Onoda Naoyoshi, Hirakawa Kosei

    CANCER RESEARCH   74 ( 19 )   2014.10( ISSN:0008-5472

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    DOI: 10.1158/1538-7445.AM2014-3818

  • The stemness of gastric cancer stem cells is sustained by TGF beta produced from cancer-associated fibroblasts Reviewed

    Yashiro Masakazu, Hasegawa Tsuyoshi, Fukuoka Tatsunari, Kinoshita Haruhito, Morisaki Tamami, Kasashima Hiroaki, Masuda Go, Kubo Naoshi, Hirakawa Kosei

    CANCER RESEARCH   74 ( 19 )   2014.10( ISSN:0008-5472

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    DOI: 10.1158/1538-7445.AM2014-3863

  • The effect of PGE2 receptor inhibitor on the microenviroment of scirrhous gastric cancer Reviewed

    Fukuoka Tatsunari, Yashiro Masakazu, Takeda Hiroshi, Maruyama Takayuki, Kasashima Hiroaki, Masuda Go, Kinoshita Haruhito, Morisaki Tamami, Sakurai Katsunobu, Shibutani Masatsune, Yamazoe Sadaaki, Kimura Kenjiro, Nagahara Hisashi, Toyokawa Takahiro, Amano Ryosuke, Kubo Naoshi, Tanaka Hiroaki, Muguruma Kazuya, Otani Hiroshi, Maeda Kiyoshi, Ohira Masaichi, Hirakawa Kosei

    CANCER RESEARCH   74 ( 19 )   2014.10( ISSN:0008-5472

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    DOI: 10.1158/1538-7445.AM2014-3606

  • Extent of intranodal macrophage correlates with lymph node metastasis of gastric cancer Reviewed

    Go Yukie, Tanaka Hiroaki, Tokumoto Mao, Okita Yoshihiro, Shibutani Masatsune, Yamazoe Sadaaki, Sakurai Katsunobu, Nagahara Hisashi, Kimura Kenjiro, Toyokawa Takahiro, Amano Ryosuke, Kubo Naoshi, Muguruma Kazuya, Otani Hiroshi, Yashiro Masakazu, Maeda Kiyoshi, Ohira Masaichi, Hirakawa Kosei

    CANCER RESEARCH   74 ( 19 )   2014.10( ISSN:0008-5472

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    DOI: 10.1158/1538-7445.AM2014-1081

  • Establishment and characterization of two cell lines of anaplastic pancreatic cancer Reviewed

    Miura Kotaro, Kimura Kenjiro, Amano Ryosuke, Yamazoe Sadaaki, Hirata Keiichiro, Shibutani Masatsune, Sakurai Katsunobu, Nagahara Hisashi, Toyokawa Takahiro, Kubo Naoshi, Tanaka Hiroaki, Muguruma Kazuya, Otani Hiroshi, Yashiro Masakazu, Maeda Kiyoshi, Ohira Masaichi, Hirakawa Kosei

    CANCER RESEARCH   74 ( 19 )   2014.10( ISSN:0008-5472

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    DOI: 10.1158/1538-7445.AM2014-3924

  • Role of lysyl oxidase and lysyl oxidase-like 2 in gastric carcinoma Reviewed

    Kasashima Hiroaki, Yashiro Masakazu, Go Yukie, Masuda Go, Kinoshita Haruhito, Tokumoto Mao, Morisaki Tamami, Fukuoka Tatsunari, Toyokawa Takahiro, Kubo Naoshi, Tanaka Hiroaki, Muguruma Kazuya, Ohira Masaichi, Hirakawa Kosei

    CANCER RESEARCH   74 ( 19 )   2014.10( ISSN:0008-5472

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    DOI: 10.1158/1538-7445.AM2014-1980

  • Stromal fibroblasts mediate extracellular matrix remodeling and invasion of scirrhous gastric carcinoma cells Reviewed

    Yamaguchi Hideki, Yanagihara Kazuyoshi, Yashiro Masakazu, Sakai Ryuichi

    CANCER RESEARCH   74 ( 19 )   2014.10( ISSN:0008-5472

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    DOI: 10.1158/1538-7445.AM2014-3601

  • Tumor budding and E-cadherin expression are useful predictors of nodal involvement in T1 esophageal squamous cell carcinoma Reviewed

    Kubo Naoshi, Ohira Masaichi, Sakurai Katsunobu, Toyokawa Takahiro, Tanaka Hiroaki, Muguruma Kazuya, Yashiro Masakazu, Maeda Kiyoshi, Onoda Naoyoshi, Hirakawa Kosei

    CANCER RESEARCH   74 ( 19 )   2014.10( ISSN:0008-5472

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    DOI: 10.1158/1538-7445.AM2014-3818

  • MicroRNA-145 is a potential prognostic factor of scirrhous type gastric cancer Reviewed

    Naito Yutaka, Yasuno Kyohei, Tagawa Hiroko, Sakamoto Naoya, Oue Naohide, Yashiro Masakazu, Sentani Kazuhiro, Goto Keisuke, Shinmei Shunsuke, Oo Htoo Zarni, Yanagihara Kazuyoshi, Hirakawa Kosei, Yasui Wataru

    ONCOLOGY REPORTS   32 ( 4 )   1720 - 1726   2014.10( ISSN:1021-335X

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    DOI: 10.3892/or.2014.3333

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  • Significance of preoperative nutritional assessment for gastric cancer patients with gastrectomy Reviewed

    Sakurai Katsunobu, Muguruma Kazuya, Toyokawa Takahiro, Kubo Naoshi, Tanaka Hiroaki, Yashiro Masakazu, Ohira Masaichi, Hirakawa Kosei

    JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS   219 ( 4 )   E173 - E173   2014.10( ISSN:1072-7515

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  • MicroRNA-145 is a potential prognostic factor of scirrhous type gastric cancer Reviewed

    Yutaka Naito, Kyohei Yasuno, Hiroko Tagawa, Naoya Sakamoto, Naohide Oue, Masakazu Yashiro, Kazuhiro Sentani, Keisuke Goto, Shunsuke Shinmei, Htoo Zarni Oo, Kazuyoshi Yanagihara, Kosei Hirakawa, Wataru Yasui

    ONCOLOGY REPORTS   32 ( 4 )   1720 - 6   2014.10( ISSN:1021-335X ( eISSN:1791-2431

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    Gastric cancer (GC) is one of the most common malignancies worldwide. In particular, scirrhous type GC is highly metastatic and is characterized clinically by rapid disease progression and poor prognosis. MicroRNAs (miRNAs) play crucial roles in cancer development and progression. We previously demonstrated by microarray analysis that microRNA-145 (miR-145) is one of the more highly expressed miRNAs in scirrhous type GC vs. non-scirrhous types of GC. In the present study, we investigated the role of miR-145 in scirrhous type GC. The expression levels of miR-145 assessed by quantitative RT-PCR were higher in scirrhous type GC tissue samples than in non-scirrhous type GC and corresponding normal tissues. GC patients with high miR-145 expression were at a more advanced tumor stage (P=0.0156) and had more scirrhous type histology (P=0.0054) than those with low miR-145 expression. Furthermore, miR-145 expression was significantly associated with poor prognosis in GC patients (P=0.0438). miR-145 expression was localized in stromal fibroblasts of scirrhous type GC but not in cancer cells. miR-145 was induced by treatment by transforming growth factor-beta, and it enhanced the expression of a-smooth muscle actin, a marker of myofibroblasts, in both normal gastric fibroblasts and cancer-associated fibroblasts. These data suggest that miR-145 may contribute to the progression of scirrhous type GC by regulating activation of peri-tumoral fibroblasts.

    DOI: 10.3892/or.2014.3333

    PubMed

  • 胃癌所属リンパ節転移予測因子としてのマクロファージ関連リンパ管新生の検討 Reviewed

    呉 幸枝, 田中 浩明, 徳本 真央, 大北 仁裕, 櫻井 克宣, 豊川 貴弘, 久保 尚士, 六車 一哉, 八代 正和, 澤田 鉄二, 大平 雅一, 平川 弘聖

    日本消化器外科学会雑誌   47 ( Suppl.2 )   154 - 154   2014.10( ISSN:0386-9768 ( eISSN:1348-9372

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  • Epigenetic silencing of miR-210 increases the proliferation of gastric epithelium during chronic Helicobacter pylori infection Reviewed

    Kotaro Kiga, Hitomi Mimuro, Masato Suzuki, Aya Shinozaki-Ushiku, Taira Kobayashi, Takahito Sanada, Minsoo Kim, Michinaga Ogawa, Yuka W. Iwasaki, Hiroyuki Kayo, Yoko Fukuda-Yuzawa, Masakazu Yashiro, Masashi Fukayama, Taro Fukao, Chihiro Sasakawa

    NATURE COMMUNICATIONS   5   4497   2014.09( ISSN:2041-1723

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    Persistent colonization of the gastric mucosa by Helicobacter pylori (Hp) elicits chronic inflammation and aberrant epithelial cell proliferation, which increases the risk of gastric cancer. Here we examine the ability of microRNAs to modulate gastric cell proliferation in response to persistent Hp infection and find that epigenetic silencing of miR-210 plays a key role in gastric disease progression. Importantly, DNA methylation of the miR-210 gene is increased in Hp-positive human gastric biopsies as compared with Hp-negative controls. Moreover, silencing of miR-210 in gastric epithelial cells promotes proliferation. We identify STMN1 and DIMT1 as miR-210 target genes and demonstrate that inhibition of miR-210 expression augments cell proliferation by activating STMN1 and DIMT1. Together, our results highlight inflammation-induced epigenetic silencing of miR-210 as a mechanism of induction of chronic gastric diseases, including cancer, during Hp infection.

    DOI: 10.1038/ncomms5497

    PubMed

  • Epigenetic silencing of miR-210 increases the proliferation of gastric epithelium during chronic Helicobacter pylori infection Reviewed

    Kiga Kotaro, Mimuro Hitomi, Suzuki Masato, Shinozaki-Ushiku Aya, Kobayashi Taira, Sanada Takahito, Kim Minsoo, Ogawa Michinaga, Iwasaki Yuka W., Kayo Hiroyuki, Fukuda-Yuzawa Yoko, Yashiro Masakazu, Fukayama Masashi, Fukao Taro, Sasakawa Chihiro

    NATURE COMMUNICATIONS   5   4497   2014.09( ISSN:2041-1723

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    DOI: 10.1038/ncomms5497

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  • The Role of PI3K/Akt/mTOR Signaling in Gastric Carcinoma Reviewed

    Matsuoka Tasuku, Yashiro Masakazu

    CANCERS   6 ( 3 )   1441 - 1463   2014.09( ISSN:2072-6694

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    DOI: 10.3390/cancers6031441

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  • The Role of PI3K/Akt/mTOR Signaling in Gastric Carcinoma Reviewed

    Tasuku Matsuoka, Masakazu Yashiro

    CANCERS   6 ( 3 )   1441 - 63   2014.07( ISSN:2072-6694

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    The phosphatidylinositol 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) pathway is one of the key signaling pathways induced by various receptor-tyrosine kinases. Accumulating evidence shows that this pathway is an important promoter of cell growth, metabolism, survival, metastasis, and resistance to chemotherapy. Genetic alterations in the PI3K/Akt/mTOR pathway in gastric carcinoma have often been demonstrated. Many kinds of molecular targeting therapies are currently undergoing clinical testing in patients with solid tumors. However, with the exception of the ErbB2-targeting antibody, targeting agents, including PI3K/Akt/mTOR inhibitors, have not been approved for treatment of patients with gastric carcinoma. This review summarizes the current knowledge on PI3K/Akt/mTOR signaling in the pathogenesis of gastric carcinoma and the possible therapeutic targets for gastric carcinoma. Improved knowledge of the PI3K/Akt/mTOR pathway in gastric carcinoma will be useful in understanding the mechanisms of tumor development and for identifying ideal targets of anticancer therapy for gastric carcinoma.

    DOI: 10.3390/cancers6031441

    PubMed

  • A prognostic indicator for the resection of liver metastasis of colorectal cancer Reviewed

    Amano Ryosuke, Yamada Nobuya, Nakata Bunzo, Kimura Kenjiro, Yashiro Masakazu, Ohira Masaichi, Hirakawa Kosei

    SURGERY TODAY   44 ( 7 )   1287 - 1292   2014.07( ISSN:0941-1291

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    DOI: 10.1007/s00595-013-0699-x

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  • Comparative study of the antitumor activity of Nab-paclitaxel and intraperitoneal solvent-based paclitaxel regarding peritoneal metastasis in gastric cancer. Reviewed

    Kinoshita J, Fushida S, Tsukada T, Oyama K, Watanabe T, Shoji M, Okamoto K, Nakanuma S, Sakai S, Makino I, Furukawa H, Hayashi H, Nakamura K, Inokuchi M, Nakagawara H, Miyashita T, Tajima H, Takamura H, Ninomiya I, Fujimura T, Masakazu Y, Hirakawa K, Ohta T

    Oncology reports   32 ( 1 )   89 - 96   2014.07( ISSN:1021-335X

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    DOI: 10.3892/or.2014.3210

    PubMed

  • 大腸癌肝転移の切除の予後指標(A prognostic indicator for the resection of liver metastasis of colorectal cancer) Reviewed

    Amano Ryosuke, Yamada Nobuya, Nakata Bunzo, Kimura Kenjiro, Yashiro Masakazu, Ohira Masaichi, Hirakawa Kosei

    シュプリンガー・ジャパン(株) Surgery Today   44 ( 7 )   1287 - 1292   2014.07( ISSN:0941-1291

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    大腸癌肝転移の外科的切除の予後を予測する指標を検討とした。大腸癌肝転移患者117例に132ヶ所の肝切除を施行した。肝転移の範囲を大腸癌取扱い規約(JCCRC)に従って分類し、患者をJCCRC分類および原発腫瘍のリンパ節浸潤の状態に基づいて病期別に分類した。生存期間中央値は58ヵ月であり、生存率は1年目が92.3%、3年目が60.0%、および5年目が46.1%であった。多変量解析では、JCCRC病期分類が生存期間中央値および5年生存率の独立予後指標であった。JCCRC病期分類は大腸癌肝転移における有意な予後指標であり、肝転移の治療の選択に有用な可能性があることが示された。

  • Comparative study of the antitumor activity of Nab-paclitaxel and intraperitoneal solvent-based paclitaxel regarding peritoneal metastasis in gastric cancer Reviewed

    Jun Kinoshita, Sachio Fushida, Tomoya Tsukada, Katsunobu Oyama, Toshihumi Watanabe, Masatoshi Shoji, Koichi Okamoto, Shinichi Nakanuma, Seisho Sakai, Isamu Makino, Hiroyuki Furukawa, Hironori Hayashi, Keishi Nakamura, Masahumi Inokuchi, Hisatoshi Nakagawara, Tomoharu Miyashita, Hidehiro Tajima, Hiroyuki Takamura, Itasu Ninomiya, Takashi Fujimura, Yashiro Masakazu, Kosei Hirakawa, Tetsuo Ohta

    ONCOLOGY REPORTS   32 ( 1 )   89 - 96   2014.07( ISSN:1021-335X ( eISSN:1791-2431

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    Intraperitoneal (i.p) chemotherapy with paclitaxel (PTX) has been shown to be a promising treatment strategy for peritoneal metastasis. The present study focused on the comparative evaluation of the therapeutic efficacy of nanopartide albumin-bound PTX (Nab-PTX) and i.p. administration of the conventional solvent-based PTX (Sb-PTX). We also investigated the difference in antitumor activity depending on the route of administration in the Nab-PTX treatment. Nab-PTX was administered i.p. or intravenously (i.v) and Sb-PTX was administered i.p. at equitoxic and equal doses to nude mice bearing gastric cancer OCUM-2MD3 cell subcutaneous and peritoneal xenografts. Therapeutic efficacy of Sb-PTX and Nab-PTX was evaluated as inhibition of tumor growth using a peritoneal metastatic model with subcutaneous xenografts. The survival rate was also investigated using mouse peritoneal models. For assessment of subcutaneous tumors, the change in tumor volume was measured, and for assessment of peritoneal tumors, the weight of ascitic fluid and the total peritoneal tumor burden were measured for each individual mouse. At equitoxic doses, treatment with Nab-PTX resulted in a greater reduction in the size of subcutaneous tumors and the weight of ascites and peritoneal burden as compared with i.p. Sb-PTX (P&lt;0.05). Treatment with i.p. and i.v. Nab-PTX also achieved greater survival benefit than i.p. Sb-PTX (P&lt;0.05). In contrast, there was no significant difference in the degree of tumor reduction and the survival time between both drugs at equal doses. With regard to the route of administration, the antitumor efficacy of Nab-PTX after i.v. administration was equivalent to the efficacy after i.p. administration. These results suggest that i.v. Nab-PTX may be another encouraging treatment option that can target peritoneal dissemination in gastric cancer.

    DOI: 10.3892/or.2014.3210

    PubMed

  • A prognostic indicator for the resection of liver metastasis of colorectal cancer Reviewed

    Ryosuke Amano, Nobuya Yamada, Bunzo Nakata, Kenjiro Kimura, Masakazu Yashiro, Masaichi Ohira, Kosei Hirakawa

    SURGERY TODAY   44 ( 7 )   1287 - 92   2014.07( ISSN:0941-1291 ( eISSN:1436-2813

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    We investigated the predictive indicator for a good prognosis of surgical resection for liver metastasis of colorectal cancer.
    Between 1990 and 2009 at our institute, 117 patients underwent 132 hepatic resections for liver metastasis of colorectal cancer. The clinical, pathological, and outcome parameters affecting their prognoses were analyzed. The extent of the liver metastases was subdivided according to the Japanese Classification of Colorectal Carcinoma (JCCRC), and the patients were classified into different grades based on the JCCRC classification and the status of the nodal involvement of the primary tumor.
    The median survival time (MST) of the 117 patients was 58 months, and the actuarial survival rates at 1, 3, and 5 years were 92.3, 60.0, and 46.1 %, respectively. A multivariate analysis revealed that the JCCRC Grade classification was an independent prognostic indicator (Grade A vs. B vs. C: MST, 72 vs. 41 vs. 23 months; 5-year survival, 59.0 vs. 38.6 vs. 0 %: p &lt; 0.0001).
    Our findings indicate that the JCCRC Grade classification for liver metastasis of colorectal cancer is a significant prognostic indicator and may be useful for making decisions regarding the treatment of liver metastasis.

    DOI: 10.1007/s00595-013-0699-x

    PubMed

  • 大腸癌肝転移の切除の予後指標(A prognostic indicator for the resection of liver metastasis of colorectal cancer) Reviewed

    Amano Ryosuke, Yamada Nobuya, Nakata Bunzo, Kimura Kenjiro, Yashiro Masakazu, Ohira Masaichi, Hirakawa Kosei

    Surgery Today   44 ( 7 )   1287 - 1292   2014.07( ISSN:0941-1291

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    大腸癌肝転移の外科的切除の予後を予測する指標を検討とした。大腸癌肝転移患者117例に132ヶ所の肝切除を施行した。肝転移の範囲を大腸癌取扱い規約(JCCRC)に従って分類し、患者をJCCRC分類および原発腫瘍のリンパ節浸潤の状態に基づいて病期別に分類した。生存期間中央値は58ヵ月であり、生存率は1年目が92.3%、3年目が60.0%、および5年目が46.1%であった。多変量解析では、JCCRC病期分類が生存期間中央値および5年生存率の独立予後指標であった。JCCRC病期分類は大腸癌肝転移における有意な予後指標であり、肝転移の治療の選択に有用な可能性があることが示された。

  • Carbonic anhydrase 9 is associated with chemosensitivity and prognosis in breast cancer patients treated with taxane and anthracycline Reviewed

    Aomatsu Naoki, Yashiro Masakazu, Kashiwagi Shinichiro, Kawajiri Hidemi, Takashima Tsutomu, Ohsawa Masahiko, Wakasa Kenichi, Hirakawa Kosei

    BMC CANCER   14   400   2014.06( ISSN:1471-2407

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    DOI: 10.1186/1471-2407-14-400

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  • Carbonic anhydrase 9 is associated with chemosensitivity and prognosis in breast cancer patients treated with taxane and anthracycline Reviewed

    Naoki Aomatsu, Masakazu Yashiro, Shinichiro Kashiwagi, Hidemi Kawajiri, Tsutomu Takashima, Masahiko Ohsawa, Kenichi Wakasa, Kosei Hirakawa

    BMC CANCER   14   400   2014.06( ISSN:1471-2407

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    Publishing type:Research paper (scientific journal)  

    Background: Neoadjuvant chemotherapy (NAC) is one of the standard care regimens for patients with resectable early-stage breast cancer. It would be advantageous to determine the chemosensitivity of tumors before initiating NAC. One of the parameters potentially compromising such chemosensitivity would be a hypoxic microenvironment of cancer cells. The aim of this study was thus to clarify the correlation between expression of the hypoxic marker carbonic anhydrase-9 (CA9) and chemosensitivity to NAC as well as prognosis of breast cancer patients.
    Methods: A total of 102 patients with resectable early-stage breast cancer was treated with NAC consisting of FEC (5-fluorouracil, epirubicin, and cyclophosphamide) followed by weekly paclitaxel before surgery. Core needle biopsy (CNB) specimens and resected tumors were obtained from all patients before and after NAC, respectively. Chemosensitivity to NAC and the prognostic potential of CA9 expression were evaluated by immunohistochemistry.
    Results: CA9 positivity was detected in the CNB specimens from 47 (46%) of 102 patients. The CA9 expression in CNB specimens was significantly correlated with pathological response, lymph node metastasis, and lymph-vascular invasion. Multivariate analysis revealed that the CA9 expression in CNB specimens was an independent predictive factor for pathological response. The Kaplan-Meier survival curve revealed a significant negative correlation (p = 0.013) between the disease-free survival (DFS) and the CA 9 expression in resected tissues after NAC. Multivariate regression analyses indicated that the CA9 expression in resected tissues was an independent prognostic factor for DFS.
    Conclusions: CA9 expression in CNB specimens is a useful marker for predicting chemosensitivity, and CA9 expression in resected tissue is prognostic of DFS in patients with resectable early-stage breast cancer treated by sequential FEC and weekly paclitaxel prior to resection.

    DOI: 10.1186/1471-2407-14-400

    PubMed

  • The Role of Type D Prostanoid Receptors and PPAR gamma in Gastric Cancer Progression Reviewed

    Fukuoka Tatsunari, Yashiro Masakazu, Morisaki Tamami, Kinoshita Haruhito, Hasegawa Tsuyoshi, Kasashima Hiroaki, Masuda Go, Sakurai Katsunobu, Toyokawa Takahiro, Tanaka Hiroaki, Kubo Naoshi, Muguruma Kazuya, Ohira Masaichi, Hirakawa Kosei

    ANTICANCER RESEARCH   34 ( 6 )   2771 - 2778   2014.06( ISSN:0250-7005

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  • The role of type D prostanoid receptors and PPARγ in gastric cancer progression. Reviewed

    Fukuoka T, Yashiro M, Morisaki T, Kinoshita H, Hasegawa T, Kasashima H, Masuda G, Sakurai K, Toyokawa T, Tanaka H, Kubo N, Muguruma K, Ohira M, Hirakawa K

    Anticancer research   34 ( 6 )   2771 - 8   2014.06( ISSN:0250-7005

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    PubMed

  • The role of type D prostanoid receptors and PPARγ in gastric cancer progression. Reviewed

    Fukuoka T, Yashiro M, Morisaki T, Kinoshita H, Hasegawa T, Kasashima H, Masuda G, Sakurai K, Toyokawa T, Tanaka H, Kubo N, Muguruma K, Ohira M, Hirakawa K

    Anticancer research   34 ( 6 )   2771 - 8   2014.06( ISSN:0250-7005

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    PubMed

  • The Role of Type D Prostanoid Receptors and PPAR gamma in Gastric Cancer Progression Reviewed

    Tatsunari Fukuoka, Masakazu Yashiro, Tamami Morisaki, Haruhito Kinoshita, Tsuyoshi Hasegawa, Hiroaki Kasashima, Go Masuda, Katsunobu Sakurai, Takahiro Toyokawa, Hiroaki Tanaka, Naoshi Kubo, Kazuya Muguruma, Masaichi Ohira, Kosei Hirakawa

    ANTICANCER RESEARCH   34 ( 6 )   2771 - 2778   2014.06( ISSN:0250-7005 ( eISSN:1791-7530

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    Prostaglandin D-2 (PGD(2)) has been demonstrated to have antitumor effects on cancer cells. PGD(2) acts through two major receptors of DP1 and DP2, as well as through the peroxisome proliferator-activated receptor gamma (PPAR gamma) via the PGD(2) metabolite, 15-deoxy-Delta 12-14-PGJ(2). The expression levels of DP1, DP2, and PPAR gamma were analyzed by immunohistochemistry on 277 primary gastric carcinomas. Either DP1- or DP2-positive cases were regarded as DP-positive. DP-Positive tumour was significantly associated with lymph mode metastasis, lymphatic invasion, and venous invasion. PPAR gamma positivity was not associated with any clinicopathological factors of gastric cancer. DP-Negative and PPAR gamma-positive cases were significantly associated with T category, lymph metastasis, and lymphatic invasion. The prognosis of DP-negative and PPAR gamma-positive cases was better than that of the other cases. These findings suggest that DP and PPAR gamma signaling influence the invasiveness of cancer cells. DP and PPAR gamma can be used as a potential marker for gastric cancer progression.

    PubMed

  • 腫瘍関連マクロファージと胃癌リンパ節転移の相関関係 Reviewed

    呉 幸枝, 田中 浩明, 徳本 真央, 大北 仁裕, 櫻井 克宣, 豊川 貴弘, 久保 尚士, 六車 一哉, 八代 正和, 澤田 鉄二, 大平 雅一, 平川 弘聖

    日本癌治療学会誌   49 ( 3 )   2274 - 2274   2014.06( ISSN:0021-4671

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  • The Impact of Combined Thoracoscopic and Laparoscopic Surgery on Pulmonary Complications After Radical Esophagectomy in Patients With Resectable Esophageal Cancer Reviewed

    Kubo Naoshi, Ohira Masaichi, Yamashita Yoshito, Sakurai Katsunobu, Toyokawa Takahiro, Tanaka Hiroaki, Muguruma Kazuya, Shibutani Masatsune, Yamazoe Sadaaki, Kimura Kenjiro, Nagahara Hisashi, Amano Ryosuke, Ohtani Hiroshi, Yashiro Masakazu, Maeda Kiyoshi, Hirakawa Kosei

    ANTICANCER RESEARCH   34 ( 5 )   2399 - 2404   2014.05( ISSN:0250-7005

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  • The impact of combined thoracoscopic and laparoscopic surgery on pulmonary complications after radical esophagectomy in patients with resectable esophageal cancer. Reviewed

    Kubo N, Ohira M, Yamashita Y, Sakurai K, Toyokawa T, Tanaka H, Muguruma K, Shibutani M, Yamazoe S, Kimura K, Nagahara H, Amano R, Ohtani H, Yashiro M, Maeda K, Hirakawa K

    Anticancer research   34 ( 5 )   2399 - 404   2014.05( ISSN:0250-7005

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    PubMed

  • The Impact of Combined Thoracoscopic and Laparoscopic Surgery on Pulmonary Complications After Radical Esophagectomy in Patients With Resectable Esophageal Cancer Reviewed

    Naoshi Kubo, Masaichi Ohira, Yoshito Yamashita, Katsunobu Sakurai, Takahiro Toyokawa, Hiroaki Tanaka, Kazuya Muguruma, Masatsune Shibutani, Sadaaki Yamazoe, Kenjiro Kimura, Hisashi Nagahara, Ryosuke Amano, Hiroshi Ohtani, Masakazu Yashiro, Kiyoshi Maeda, Kosei Hirakawa

    ANTICANCER RESEARCH   34 ( 5 )   2399 - 2404   2014.05( ISSN:0250-7005 ( eISSN:1791-7530

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    Background: Pulmonary complications (PCs) after esophagectomy for patients with esophageal cancer have been correlated with prolonged hospital stays and in-hospital mortality. Previous studies have shown that minimally-invasive esophagectomy (MIE) is associated with a lower rate of PCs compared to conventional open surgery. Although PCs were reportedly associated with many factors, including surgical approaches, patients' demographics, and perioperative variables, the predictive factors for PCs including MIE, have not been fully evaluated. Patients and Methods: A total of 209 patients with resectable esophageal cancer who underwent three types of esophagectomy were included in the present study; (i) 93 cases who underwent the combined thoracoscopic MIE and laparoscopic MIE; (ii) 42 cases who underwent the combined open thoracotomy and laparoscopic MIE; (iii) 74 cases who underwent the combined open thoracotomy and open laparotomy, which were defined as the total MIE group, hybrid MIE group, and total open group, respectively. We compared clinical outcomes of the three groups and identified postoperative predictive factors of PCs using multivariate analysis. Results: The incidence of PCs was significantly reduced (p=0.015) in the total-MIE group (8193: 8.5%) compared with the total-open group (16/74: 21.6%), but it was not significantly reduced in the hybrid MIE group (5142: 11.9%) compared with the total open group (p=0.19). The multivariate analysis showed that the presence of cardiac comorbidity [odds ratio (OR)=5.90; p=0.013], lung comorbidity (OR=3.95; p=0.031), and anastomotic leakage (OR=6.00; p&lt;0.01) were independent risk factors for PCs after esophagectomy. In contrast, total MIE reduced the risk of PCs (OR=0.328; p=0.036). Conclusion: The combination of thoracoscopic and laparoscopic MIE presents as an excellent surgical procedure for the reduction of PCs after esophagectomy.

    PubMed

  • The impact of combined thoracoscopic and laparoscopic surgery on pulmonary complications after radical esophagectomy in patients with resectable esophageal cancer. Reviewed

    Kubo N, Ohira M, Yamashita Y, Sakurai K, Toyokawa T, Tanaka H, Muguruma K, Shibutani M, Yamazoe S, Kimura K, Nagahara H, Amano R, Ohtani H, Yashiro M, Maeda K, Hirakawa K

    Anticancer research   34 ( 5 )   2399 - 404   2014.05( ISSN:0250-7005

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    PubMed

  • Cancer-associated fibroblasts might sustain the stemness of scirrhous gastric cancer cells via transforming growth factor-beta signaling Reviewed

    Hasegawa Tsuyoshi, Yashiro Masakazu, Nishii Takafumi, Matsuoka Junko, Fuyuhiro Yuhiko, Morisaki Tamami, Fukuoka Tatsunari, Shimizu Kiyoshi, Shimizu Toshiyuki, Miwa Atsushi, Hirakawa Kosei

    INTERNATIONAL JOURNAL OF CANCER   134 ( 8 )   1785 - 1795   2014.04( ISSN:0020-7136

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    DOI: 10.1002/ijc.28520

    PubMed

  • Cancer-associated fibroblasts might sustain the stemness of scirrhous gastric cancer cells via transforming growth factor-beta signaling Reviewed

    Tsuyoshi Hasegawa, Masakazu Yashiro, Takafumi Nishii, Junko Matsuoka, Yuhiko Fuyuhiro, Tamami Morisaki, Tatsunari Fukuoka, Kiyoshi Shimizu, Toshiyuki Shimizu, Atsushi Miwa, Kosei Hirakawa

    INTERNATIONAL JOURNAL OF CANCER   134 ( 8 )   1785 - 95   2014.04( ISSN:0020-7136 ( eISSN:1097-0215

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    Cancer-associated fibroblasts (CAFs) have recently been implicated in tumor growth and metastasis in gastric cancer. Cancer stem cells (CSCs) have been proposed to have an important role in cancer progression. The aim of this study was to clarify the effect of CAFs on CSCs characteristics in gastric carcinoma. Scirrhous gastric cancer cell lines, OCUM-12 and OCUM-2MD3, and non-scirrhous gastric cancer cell lines, MKN-45 and MKN-74, were used. OCUM-12/side population (SP) cells and OCUM-2MD3/SP cells were sorted by flow cytometry as CSC-rich cells from the parent cells. CaF-37 was established from the tumoral gastric specimens as CAFs. Flow cytometric analysis of SP fraction, spheroid colony assay, and RT-PCR analysis of CSC markers were performed to identify CSCs properties. Effect of CAFs on the tumorigenicity by OCUM-12/SP cells was examined using nude mice. CAF CM significantly increased the percentages of the SP fraction of OCUM-12/SP and OCUM-2MD3/SP cells, but not that of MKN-45/SP and MKN-74/SP cells. Taken together, CM from CaF-37 significantly increased the number of spheroid colonies and the expression level of CSC markers of OCUM-12/SP and OCUM-2MD3/SP cells. These stimulating-activities by CM were significantly decreased by TGF inhibitors, but not FGFR and cMet inhibitor. Tumorigenicity by subcutaneous coinoculation of OCUM-12/SP cells with CAFs was significantly high in comparison with that by OCUM-12/SP cells alone. Phospho-Smad2 expression level was significantly increased by co-inoculation with CAFs. These findings suggested that CAFs might regulate the stemness of CSCs in scirrhous gastric cancer by TGF signaling.

    DOI: 10.1002/ijc.28520

    PubMed

  • Thoracoscopic Esophagectomy in the Prone Position Versus in the Lateral Position for Patients With Esophageal Cancer: A Comparison of Short-term Surgical Results Reviewed

    Kubo Naoshi, Ohira Masaichi, Yamashita Yoshito, Sakurai Katsunobu, Lee Tomohiro, Toyokawa Takahiro, Tanaka Hiroaki, Muguruma Kazuya, Kimura Kenjiro, Nagahara Hisashi, Amano Ryosuke, Noda Eiji, Ohtani Hiroshi, Yashiro Masakazu, Maeda Kiyoshi, Hirakawa Kosei

    SURGICAL LAPAROSCOPY ENDOSCOPY & PERCUTANEOUS TECHNIQUES   24 ( 2 )   158 - 163   2014.04( ISSN:1530-4515

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    DOI: 10.1097/SLE.0b013e31828fa6d7

    PubMed

  • Thoracoscopic Esophagectomy in the Prone Position Versus in the Lateral Position for Patients With Esophageal Cancer: A Comparison of Short-term Surgical Results Reviewed

    Naoshi Kubo, Masaichi Ohira, Yoshito Yamashita, Katsunobu Sakurai, Tomohiro Lee, Takahiro Toyokawa, Hiroaki Tanaka, Kazuya Muguruma, Kenjiro Kimura, Hisashi Nagahara, Ryosuke Amano, Eiji Noda, Hiroshi Ohtani, Masakazu Yashiro, Kiyoshi Maeda, Kosei Hirakawa

    SURGICAL LAPAROSCOPY ENDOSCOPY & PERCUTANEOUS TECHNIQUES   24 ( 2 )   158 - 63   2014.04( ISSN:1530-4515 ( eISSN:1534-4908

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    Aim:
    Thoracoscopic esophagectomy (TE) in the prone position for patients with esophageal cancer has received a great deal of attention. We retrospectively compared clinical outcomes and surgical stress of TE in the prone position (TE-P) and in the lateral position (TE-L) at our institution.
    Methods:
    A total of 58 consecutive patients (28 in the TE-L group and 30 in the TE-P group) were studied. Between the 2 groups, clinical outcomes and various parameters were compared.
    Results:
    There were no hospital deaths in both TEL and TEP groups. Blood loss during the thoracoscopic part of the surgery were significantly (P &lt; 0.01) lower in the TE-P group (118 +/- 72 mL) compared with the TE-L (245 +/- 203 mL) group. The incidence of respiratory complications tended to be lower (P=0.07) in the TE-P group (3.3%) than in the TE-L (17.8%) group. The duration of systemic inflammatory response syndrome condition was significantly (P=0.02) shorter in the TE-P group (1.5 +/- 2.5 d) than in TE-L (3.6 +/- 3.5 d) group. The levels of serum C-reactive protein on postoperative days 1 and 2 were significantly (P &lt; 0.01) lower in the TE-P group than in the TE-L group.
    Conclusions:
    TE-P for patients with esophageal cancer was safe and feasible. TE-P might be a potentially less invasive procedure than TE-L.

    DOI: 10.1097/SLE.0b013e31828fa6d7

    PubMed

  • プロスタグランジンD2による胃癌抑制効果 Reviewed

    福岡 達成, 八代 正和, 笠島 裕明, 増田 剛, 呉 幸枝, 木下 春人, 渡辺 真央, 森崎 珠実, 大北 仁裕, 櫻井 克宣, 豊川 貴弘, 久保 尚士, 田中 浩明, 六車 一哉, 大平 雅一, 平川 弘聖

    日本分子腫瘍マーカー研究会誌   29   36 - 37   2014.04( eISSN:2433-8575

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  • OP-009-6 主要動脈浸潤を伴う局所進行膵癌に対する化学放射線療法後の外科切除の意義(OP-009 膵 膵癌-1,一般演題,第114回日本外科学会定期学術集会) Reviewed

    天野 良亮, 木村 健二郎, 山添 定明, 平田 啓一郎, 永原 央, 豊川 貴弘, 久保 尚士, 田中 浩明, 六車 一哉, 大谷 博, 八代 正和, 前田 清, 仲田 文造, 平川 弘聖

    一般社団法人日本外科学会 日本外科学会雑誌   115 ( 2 )   2014.03( ISSN:18801129

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    CiNii Article

  • PS-210-7 併存疾患を有する胃癌患者に対する鏡視下手術の周術期成績(PS-210 胃 高齢者-2・その他,ポスターセッション,第114回日本外科学会定期学術集会) Reviewed

    櫻井 克宣, 六車 一哉, 石原 沙江, 西尾 康平, 田村 達郎, 平田 啓一郎, 渋谷 雅常, 山添 定明, 木村 健二郎, 永原 央, 豊川 貴弘, 天野 良亮, 久保 尚士, 田中 浩明, 大谷 博, 八代 正和, 山下 好人, 前田 清, 澤田 鉄二, 大平 雅一, 平川 弘聖

    一般社団法人日本外科学会 日本外科学会雑誌   115 ( 2 )   2014.03( ISSN:18801129

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  • PS-207-3 胸部食道癌に対する腹臥位胸腔鏡下食道切除術の有用性(PS-207 食道 鏡視下手術-1,ポスターセッション,第114回日本外科学会定期学術集会) Reviewed

    久保 尚士, 大平 雅一, 櫻井 克宣, 豊川 貴弘, 田中 浩明, 六車 一哉, 渋谷 雅常, 山添 定明, 永原 央, 木村 健二郎, 天野 良亮, 山下 好人, 八代 正和, 前田 清, 平川 弘聖

    一般社団法人日本外科学会 日本外科学会雑誌   115 ( 2 )   2014.03( ISSN:18801129

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  • PS-175-6 胃癌における間質酵素Lysyl Oxidase発現の臨床病理学的意義(PS-175 基礎 発癌・バイオマーカー・その他-1,ポスターセッション,第114回日本外科学会定期学術集会) Reviewed

    笠島 裕明, 八代 正和, 増田 剛, 呉 幸枝, 渡邊 真央, 木下 春人, 森崎 珠実, 大北 仁裕, 福岡 達成, 櫻井 克宣, 豊川 貴弘, 久保 尚士, 田中 浩明, 六車 一哉, 大平 雅一, 平川 弘聖

    一般社団法人日本外科学会 日本外科学会雑誌   115 ( 2 )   2014.03( ISSN:18801129

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  • PS-135-7 スキルス胃癌微笑環境におけるプロスタグランジンE2の影響とその阻害剤の有効性(PS-135 胃 基礎-3,ポスターセッション,第114回日本外科学会定期学術集会) Reviewed

    福岡 達成, 八代 正和, 笠島 裕明, 増田 剛, 呉 幸枝, 木下 春人, 渡辺 真央, 大北 仁裕, 森崎 珠実, 櫻井 克宣, 木村 健二郎, 永原 央, 豊川 貴弘, 天野 良亮, 久保 尚士, 田中 浩明, 六車 一哉, 大谷 博, 前田 清, 大平 雅一, 平川 弘聖

    一般社団法人日本外科学会 日本外科学会雑誌   115 ( 2 )   2014.03( ISSN:18801129

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  • PS-134-7 胃癌におけるオートファジー関連分子p62/SQSTM1の臨床病理学的検討(PS-134 胃 基礎-2,ポスターセッション,第114回日本外科学会定期学術集会) Reviewed

    増田 剛, 八代 正和, 笠島 裕明, 渡邊 真央, 木下 春人, 森崎 珠実, 大北 仁裕, 福岡 達成, 櫻井 克宣, 永原 央, 木村 健二郎, 豊川 貴弘, 天野 良亮, 久保 尚士, 田中 浩明, 大谷 博, 六車 一哉, 前田 清, 澤田 鉄二, 大平 雅一, 平川 弘聖

    一般社団法人日本外科学会 日本外科学会雑誌   115 ( 2 )   2014.03( ISSN:18801129

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  • OP-123-3 胃全摘術におけるNo.10リンパ節転移の意義(OP-123 胃 リンパ節郭清・手術適応,一般演題,第114回日本外科学会定期学術集会) Reviewed

    森崎 珠実, 八代 正和, 呉 幸枝, 笠島 裕明, 増田 剛, 渡邊 真央, 木下 春人, 大北 仁裕, 福岡 達成, 櫻井 克宣, 豊川 貴弘, 久保 尚士, 田中 浩明, 六車 一哉, 澤田 鉄二, 大平 雅一, 平川 弘聖

    一般社団法人日本外科学会 日本外科学会雑誌   115 ( 2 )   2014.03( ISSN:18801129

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  • OP-060-2 低酸素微小環境がスキルス胃癌に与える影響(OP-060 胃 基礎-1,一般演題,第114回日本外科学会定期学術集会) Reviewed

    木下 春人, 八代 正和, 笠島 裕明, 増田 剛, 呉 幸枝, 渡邊 真央, 大北 仁裕, 森崎 珠実, 福岡 達成, 櫻井 克宣, 豊川 貴弘, 久保 尚士, 田中 浩明, 六車 一哉, 前田 清, 大平 雅一, 平川 弘聖

    一般社団法人日本外科学会 日本外科学会雑誌   115 ( 2 )   2014.03( ISSN:18801129

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  • OP-009-6 主要動脈浸潤を伴う局所進行膵癌に対する化学放射線療法後の外科切除の意義(OP-009 膵 膵癌-1,一般演題,第114回日本外科学会定期学術集会) Reviewed

    天野 良亮, 木村 健二郎, 山添 定明, 平田 啓一郎, 永原 央, 豊川 貴弘, 久保 尚士, 田中 浩明, 六車 一哉, 大谷 博, 八代 正和, 前田 清, 仲田 文造, 平川 弘聖

    日本外科学会雑誌   115 ( 2 )   328   2014.03( ISSN:18801129

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  • PS-210-7 併存疾患を有する胃癌患者に対する鏡視下手術の周術期成績(PS-210 胃 高齢者-2・その他,ポスターセッション,第114回日本外科学会定期学術集会) Reviewed

    櫻井 克宣, 六車 一哉, 石原 沙江, 西尾 康平, 田村 達郎, 平田 啓一郎, 渋谷 雅常, 山添 定明, 木村 健二郎, 永原 央, 豊川 貴弘, 天野 良亮, 久保 尚士, 田中 浩明, 大谷 博, 八代 正和, 山下 好人, 前田 清, 澤田 鉄二, 大平 雅一, 平川 弘聖

    日本外科学会雑誌   115 ( 2 )   995   2014.03( ISSN:18801129

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    CiNii Article

  • PS-207-3 胸部食道癌に対する腹臥位胸腔鏡下食道切除術の有用性(PS-207 食道 鏡視下手術-1,ポスターセッション,第114回日本外科学会定期学術集会) Reviewed

    久保 尚士, 大平 雅一, 櫻井 克宣, 豊川 貴弘, 田中 浩明, 六車 一哉, 渋谷 雅常, 山添 定明, 永原 央, 木村 健二郎, 天野 良亮, 山下 好人, 八代 正和, 前田 清, 平川 弘聖

    日本外科学会雑誌   115 ( 2 )   988   2014.03( ISSN:18801129

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  • PS-175-6 胃癌における間質酵素Lysyl Oxidase発現の臨床病理学的意義(PS-175 基礎 発癌・バイオマーカー・その他-1,ポスターセッション,第114回日本外科学会定期学術集会) Reviewed

    笠島 裕明, 八代 正和, 増田 剛, 呉 幸枝, 渡邊 真央, 木下 春人, 森崎 珠実, 大北 仁裕, 福岡 達成, 櫻井 克宣, 豊川 貴弘, 久保 尚士, 田中 浩明, 六車 一哉, 大平 雅一, 平川 弘聖

    日本外科学会雑誌   115 ( 2 )   925   2014.03( ISSN:18801129

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    CiNii Article

  • PS-135-7 スキルス胃癌微笑環境におけるプロスタグランジンE2の影響とその阻害剤の有効性(PS-135 胃 基礎-3,ポスターセッション,第114回日本外科学会定期学術集会) Reviewed

    福岡 達成, 八代 正和, 笠島 裕明, 増田 剛, 呉 幸枝, 木下 春人, 渡辺 真央, 大北 仁裕, 森崎 珠実, 櫻井 克宣, 木村 健二郎, 永原 央, 豊川 貴弘, 天野 良亮, 久保 尚士, 田中 浩明, 六車 一哉, 大谷 博, 前田 清, 大平 雅一, 平川 弘聖

    日本外科学会雑誌   115 ( 2 )   845   2014.03( ISSN:18801129

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  • PS-134-7 胃癌におけるオートファジー関連分子p62/SQSTM1の臨床病理学的検討(PS-134 胃 基礎-2,ポスターセッション,第114回日本外科学会定期学術集会) Reviewed

    増田 剛, 八代 正和, 笠島 裕明, 渡邊 真央, 木下 春人, 森崎 珠実, 大北 仁裕, 福岡 達成, 櫻井 克宣, 永原 央, 木村 健二郎, 豊川 貴弘, 天野 良亮, 久保 尚士, 田中 浩明, 大谷 博, 六車 一哉, 前田 清, 澤田 鉄二, 大平 雅一, 平川 弘聖

    日本外科学会雑誌   115 ( 2 )   843   2014.03( ISSN:18801129

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    CiNii Article

  • OP-123-3 胃全摘術におけるNo.10リンパ節転移の意義(OP-123 胃 リンパ節郭清・手術適応,一般演題,第114回日本外科学会定期学術集会) Reviewed

    森崎 珠実, 八代 正和, 呉 幸枝, 笠島 裕明, 増田 剛, 渡邊 真央, 木下 春人, 大北 仁裕, 福岡 達成, 櫻井 克宣, 豊川 貴弘, 久保 尚士, 田中 浩明, 六車 一哉, 澤田 鉄二, 大平 雅一, 平川 弘聖

    日本外科学会雑誌   115 ( 2 )   532   2014.03( ISSN:18801129

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  • OP-060-2 低酸素微小環境がスキルス胃癌に与える影響(OP-060 胃 基礎-1,一般演題,第114回日本外科学会定期学術集会) Reviewed

    木下 春人, 八代 正和, 笠島 裕明, 増田 剛, 呉 幸枝, 渡邊 真央, 大北 仁裕, 森崎 珠実, 福岡 達成, 櫻井 克宣, 豊川 貴弘, 久保 尚士, 田中 浩明, 六車 一哉, 前田 清, 大平 雅一, 平川 弘聖

    日本外科学会雑誌   115 ( 2 )   421   2014.03( ISSN:18801129

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  • The Niche Component Periostin Is Produced by Cancer-Associated Fibroblasts, Supporting Growth of Gastric Cancer through ERK Activation Reviewed

    Kikuchi Yoshinao, Kunita Akiko, Iwata Caname, Komura Daisuke, Nishiyama Takashi, Shimazu Kazuhiro, Takeshita Kimiko, Shibahara Junji, Kii Isao, Morishita Yasuyuki, Yashiro Masakazu, Hirakawa Kosei, Miyazono Kohei, Kudo Akira, Fukayama Masashi, Kashima Takeshi G.

    AMERICAN JOURNAL OF PATHOLOGY   184 ( 3 )   859 - 870   2014.03( ISSN:0002-9440

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    DOI: 10.1016/j.ajpath.2013.11.012

    PubMed

  • The Niche Component Periostin Is Produced by Cancer-Associated Fibroblasts, Supporting Growth of Gastric Cancer through ERK Activation Reviewed

    Yoshinao Kikuchi, Akiko Kunita, Caname Iwata, Daisuke Komura, Takashi Nishiyama, Kazuhiro Shimazu, Kimiko Takeshita, Junji Shibahara, Isao Kii, Yasuyuki Morishita, Masakazu Yashiro, Kosei Hirakawa, Kohei Miyazono, Akira Kudo, Masashi Fukayama, Takeshi G. Kashima

    AMERICAN JOURNAL OF PATHOLOGY   184 ( 3 )   859 - 70   2014.03( ISSN:0002-9440 ( eISSN:1525-2191

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    Overexpression of periostin (POSTN), an extraceaular matrix protein, has been observed in several cancers. We investigated the importance of POSTN in gastric cancer. Genome-wide gene expression analysis using publicly available microarray data sets revealed significantly high POSTN expression in cancer tissues from stage II-IV gastric cancer, compared with background normal tissues. The POSTN/vimentin mRNA expression ratio was highly associated with gene groups that regulate the cell cycle and cell proliferation. IHC showed that periglandular POSTN deposition, comprising Linear deposition abutting the glandular epithelial cells in normal mucosa, disappeared during intestinal gastric cancer progression. Stromal POSTN deposition was also detected at the invasive front of intestinal-type and diffuse-type cancers. In situ hybridization confirmed POSTN mRNA in cancer-associated fibroblasts, but not in tumor cells themselves. POSTN enhanced the in vitro growth of OCUM-2MLN and OCUM-12 diffuse-type gastric cancer cell lines, accompanied by the activation of ERK. Furthermore, coinoculation of gastric cancer cells with POSTN-expressing NIH3T3 mouse fibroblast cells facilitated tumor formation. The OCUM-2MLN orthotopic inoculation model demonstrated that tumors of the gastric wall in Postn(-/-) mice were significantly smaller than those in wild-type mice. Ki-67 and p-ERK positive rates were both lower in Postn(-/-) mice. These findings suggest that POSTN produced by cancerassociated fibroblasts constitutes a growth-supportive microenvironment for gastric cancer.

    DOI: 10.1016/j.ajpath.2013.11.012

    PubMed

  • スキルス胃癌微小環境におけるプロスタグランジンE2の影響とその阻害剤の有効性 Reviewed

    福岡 達成, 八代 正和, 笠島 裕明, 増田 剛, 呉 幸枝, 木下 春人, 渡辺 真央, 大北 仁裕, 森崎 珠実, 櫻井 克宣, 木村 健二郎, 永原 央, 豊川 貴弘, 天野 良亮, 久保 尚士, 田中 浩明, 六車 一哉, 大谷 博, 前田 清, 大平 雅一, 平川 弘聖

    日本外科学会雑誌   115 ( 臨増2 )   845 - 845   2014.03( ISSN:0301-4894

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  • 胃癌所属リンパ節内浸潤好中球と腫瘍進展との関連 Reviewed

    渡邊 真央, 田中 浩明, 呉 幸枝, 大北 仁裕, 櫻井 克宣, 豊川 貴弘, 久保 尚士, 六車 一哉, 八代 正和, 澤田 鉄二, 大平 雅一, 平川 弘聖

    日本胃癌学会総会記事   86回   381 - 381   2014.03

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  • 胃癌所属リンパ節内の腫瘍関連マクロファージとリンパ管新生 Reviewed

    呉 幸枝, 田中 浩明, 渡邊 真央, 大北 仁裕, 櫻井 克宣, 豊川 貴弘, 久保 尚士, 六車 一哉, 八代 正和, 澤田 鉄二, 大平 雅一, 平川 弘聖

    日本胃癌学会総会記事   86回   381 - 381   2014.03

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  • 胃癌における間質酵素Lysyl Oxidase発現の臨床病理学的意義 Reviewed

    笠島 裕明, 八代 正和, 増田 剛, 呉 幸枝, 渡邊 真央, 木下 春人, 森崎 珠実, 大北 仁裕, 福岡 達成, 櫻井 克宣, 豊川 貴弘, 久保 尚士, 田中 浩明, 六車 一哉, 大平 雅一, 平川 弘聖

    日本外科学会雑誌   115 ( 臨増2 )   925 - 925   2014.03( ISSN:0301-4894

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  • 胃癌における間質酵素Lysyl OxidaseはRO手術例の予後予測因子である Reviewed

    笠島 裕明, 八代 正和, 増田 剛, 木下 春人, 森崎 珠実, 福岡 達成, 櫻井 克宣, 大北 仁裕, 豊川 貴弘, 久保 尚士, 田中 浩明, 六車 一哉, 大平 雅一, 平川 弘聖

    日本胃癌学会総会記事   86回   386 - 386   2014.03

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  • 胃癌におけるオートファジー関連分子p62/SQSTM1の臨床病理学的検討 Reviewed

    増田 剛, 八代 正和, 笠島 裕明, 渡邊 真央, 木下 春人, 森崎 珠実, 大北 仁裕, 福岡 達成, 櫻井 克宣, 永原 央, 木村 健二郎, 豊川 貴弘, 天野 良亮, 久保 尚士, 田中 浩明, 大谷 博, 六車 一哉, 前田 清, 澤田 鉄二, 大平 雅一, 平川 弘聖

    日本外科学会雑誌   115 ( 臨増2 )   843 - 843   2014.03( ISSN:0301-4894

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  • 胃癌におけるオートファジーの臨床病理学的意義 Reviewed

    増田 剛, 八代 正和, 渡邊 真央, 木下 春人, 森崎 珠実, 大北 仁裕, 福岡 達成, 櫻井 克宣, 豊川 貴弘, 久保 尚士, 田中 浩明, 六車 一哉, 澤田 鉄二, 大平 雅一, 平川 弘聖

    日本胃癌学会総会記事   86回   251 - 251   2014.03

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  • 胃全摘術におけるNo.10リンパ節転移の意義 Reviewed

    森崎 珠実, 八代 正和, 呉 幸枝, 笠島 裕明, 増田 剛, 渡邊 真央, 木下 春人, 大北 仁裕, 福岡 達成, 櫻井 克宣, 豊川 貴弘, 久保 尚士, 田中 浩明, 六車 一哉, 澤田 鉄二, 大平 雅一, 平川 弘聖

    日本外科学会雑誌   115 ( 臨増2 )   532 - 532   2014.03( ISSN:0301-4894

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  • 低酸素環境において癌微小環境がスキルス胃癌に与える影響 Reviewed

    木下 春人, 八代 正和, 笠島 裕明, 増田 剛, 渡邊 真央, 大北 仁裕, 森崎 珠実, 福岡 達成, 櫻井 克宣, 豊川 貴弘, 久保 尚士, 田中 浩明, 六車 一哉, 大平 雅一, 平川 弘聖

    日本胃癌学会総会記事   86回   328 - 328   2014.03

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  • 低酸素微小環境がスキルス胃癌に与える影響 Reviewed

    木下 春人, 八代 正和, 笠島 裕明, 増田 剛, 呉 幸枝, 渡邊 真央, 大北 仁裕, 森崎 珠実, 福岡 達成, 櫻井 克宣, 豊川 貴弘, 久保 尚士, 田中 浩明, 六車 一哉, 前田 清, 大平 雅一, 平川 弘聖

    日本外科学会雑誌   115 ( 臨増2 )   421 - 421   2014.03( ISSN:0301-4894

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  • プロテオーム解析を用いた胃癌幹細胞関連蛋白とその臨床的意義 Reviewed

    森崎 珠実, 八代 正和, 笠島 裕明, 増田 剛, 木下 春人, 大北 仁裕, 福岡 達成, 櫻井 克宣, 豊川 貴弘, 久保 尚士, 田中 浩明, 六車 一哉, 大平 雅一, 平川 弘聖

    日本胃癌学会総会記事   86回   320 - 320   2014.03

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  • プロスタグランジンD2シグナルは胃癌細胞増殖を抑制する Reviewed

    福岡 達成, 八代 正和, 笠島 裕明, 増田 剛, 渡辺 真央, 木下 春人, 大北 仁裕, 森崎 珠実, 櫻井 克宣, 豊川 貴弘, 久保 尚士, 田中 浩明, 六車 一哉, 大平 雅一, 平川 弘聖

    日本胃癌学会総会記事   86回   316 - 316   2014.03

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  • MicroRNA-143 regulates collagen type III expression in stromal fibroblasts of scirrhous type gastric cancer Reviewed

    Naito Yutaka, Sakamoto Naoya, Oue Naohide, Yashiro Masakazu, Sentani Kazuhiro, Yanagihara Kazuyoshi, Hirakawa Kosei, Yasui Wataru

    CANCER SCIENCE   105 ( 2 )   228 - 235   2014.02( ISSN:1349-7006

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    DOI: 10.1111/cas.12329

    PubMed

  • Successful resection of esophageal carcinoma with aberrant right subclavian artery using video-assisted thoracoscopic surgery: report of two cases. Reviewed

    Kasashima H, Kubo N, Ohira M, Sakurai K, Toyokawa T, Tanaka H, Muguruma K, Shibutani M, Yamazoe S, Kimura K, Nagahara H, Amano R, Ohtani H, Yashiro M, Maeda K, Hirakawa K

    Anticancer research   34 ( 2 )   899 - 904   2014.02( ISSN:0250-7005

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    PubMed

  • Successful Resection of Esophageal Carcinoma with Aberrant Right Subclavian Artery Using Video-assisted Thoracoscopic Surgery: Report of Two Cases Reviewed

    Kasashima Hiroaki, Kubo Naoshi, Ohira Masaichi, Sakurai Katsunobu, Toyokawa Takahiro, Tanaka Hiroaki, Muguruma Kazuya, Shibutani Masatsune, Yamazoe Sadaaki, Keviura Kenjiro, Nagahara Hisashi, Amano Ryosuke, Ohtani Hiroshi, Yashiro Masakazu, Maeda Kiyoshi, Hirakawa Kosei

    ANTICANCER RESEARCH   34 ( 2 )   899 - 904   2014.02( ISSN:0250-7005

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  • マイクロRNA-143はスキルス型胃癌の間質線維芽細胞におけるコラーゲンIII型発現を調節する(MicroRNA-143 regulates collagen type III expression in stromal fibroblasts of scirrhous type gastric cancer) Reviewed

    Naito Yutaka, Sakamoto Naoya, Oue Naohide, Yashiro Masakazu, Sentani Kazuhiro, Yanagihara Kazuyoshi, Hirakawa Kosei, Yasui Wataru

    John Wiley & Sons Australia, Ltd Cancer Science   105 ( 2 )   228 - 235   2014.02( ISSN:1347-9032

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    スキルス型胃癌(GC)の間質細胞におけるマイクロRNA(miRNA)-143(miR-143)の機能を検討し、miR-143と患者予後の関係を調べた。マイクロRNA(miRNA)マイクロアレイ分析により、非スキルス型よりもスキルス型GCにおいてより高レベルで発現するいくつかのmiRNAを同定し、miR-143の発現が高かった。in situハイブリダイゼーションおよび定量的RT-PCR分析では、miR-143は間質線維芽細胞に発現していたが、癌細胞によっては発現しなかった。間質細胞では、miR-143が転換増殖因子-β/SMADシグナル伝達の活性化を介して、正常胃線維芽細胞および癌関連線維芽細胞におけるコラーゲンIII型の発現を増強した。GCにおけるmiR-143高発現は癌特異的死亡率の悪化と関連していた。多変量解析では、miR-143が独立した予後因子であった。GC細胞株を5-aza-2'-deoxycytidineで処理するとmiR-143の発現が元に戻った。miR-143前駆体は癌細胞の浸潤を阻害した。

  • MicroRNA-143 regulates collagen type III expression in stromal fibroblasts of scirrhous type gastric cancer Reviewed

    Yutaka Naito, Naoya Sakamoto, Naohide Oue, Masakazu Yashiro, Kazuhiro Sentani, Kazuyoshi Yanagihara, Kosei Hirakawa, Wataru Yasui

    Cancer Science   105 ( 2 )   228 - 235   2014.02( ISSN:1347-9032

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    Gastric cancer (GC) is one of the most common malignancies worldwide. In particular, scirrhous type GC is highly metastatic and is characterized clinically by rapid disease progression and poor prognosis. MicroRNAs (miRNAs) play crucial roles in cancer development and progression. In the present study, we identified several miRNAs that are expressed at higher levels in scirrhous type GC than in non-scirrhous type GC by miRNA microarray analysis. Among these, microRNA-143 (miR-143) expression was higher in scirrhous type GC than in non-scirrhous types of GC. In situ hybridization and quantitative RT-PCR analysis showed that miR-143 is expressed by stromal fibroblasts but not by cancer cells. In stromal cells, miR-143 enhanced collagen type III expression in normal gastric fibroblasts and cancer-associated fibroblasts through activation of transforming growth factor-β)/SMAD signaling. Furthermore, high miR-143 expression in GC was associated with worse cancer-specific mortality (P = 0.0141). Multivariate analysis revealed that miR-143 was an independent prognostic factor. Treatment of GC cell lines with 5-aza-2′-deoxycytidine restored the expression of miR-143, and precursor miR-143 caused the inhibition of cancer cell invasion. These data suggest that miR-143 regulates fibrosis of scirrhous type GC through induction of collagen expression in stromal fibroblasts and that miR-143 expression serves as a prognostic marker of GC. © 2013 The Authors.

    DOI: 10.1111/cas.12329

    PubMed

  • Successful Resection of Esophageal Carcinoma with Aberrant Right Subclavian Artery Using Video-assisted Thoracoscopic Surgery: Report of Two Cases Reviewed

    Hiroaki Kasashima, Naoshi Kubo, Masaichi Ohira, Katsunobu Sakurai, Takahiro Toyokawa, Hiroaki Tanaka, Kazuya Muguruma, Masatsune Shibutani, Sadaaki Yamazoe, Kenjiro Keviura, Hisashi Nagahara, Ryosuke Amano, Hiroshi Ohtani, Masakazu Yashiro, Kiyoshi Maeda, Kosei Hirakawa

    ANTICANCER RESEARCH   34 ( 2 )   899 - 904   2014.02( ISSN:0250-7005 ( eISSN:1791-7530

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    The right non-recurrent inferior laryngeal nerve (NRILN) is a rare nerve anomaly that communicates the laryngeal nerve to the right vagal nerve trunk directly in the neck, which is usually accompanied by aberrant right subclavian artery (ARSA). We report on two cases of thoracic esophageal carcinoma undertaken in patients with these abnormalities: a 73-year-old woman with progressive dysphagia and a 63-year-old asymptomatic man. Although there have been 10 cases of thoracic esophageal carcinomas associated with ARSA and NRILN in literature, as far as we are aware of, this is the first report to describe successful resection using video-assisted thoracoscopic surgery (VATS). We found that the combination of preoperative recognition of the ARSA using three-dimensional computed tomography (3D-CT) and VATS in the prone position allowed for visual magnification with an excellent thoracoscopic view and facilitated successful tumor resection and preservation of NRILN.

    PubMed

  • マイクロRNA-143はスキルス型胃癌の間質線維芽細胞におけるコラーゲンIII型発現を調節する(MicroRNA-143 regulates collagen type III expression in stromal fibroblasts of scirrhous type gastric cancer) Reviewed

    Naito Yutaka, Sakamoto Naoya, Oue Naohide, Yashiro Masakazu, Sentani Kazuhiro, Yanagihara Kazuyoshi, Hirakawa Kosei, Yasui Wataru

    Cancer Science   105 ( 2 )   228 - 235   2014.02( ISSN:1347-9032

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    スキルス型胃癌(GC)の間質細胞におけるマイクロRNA(miRNA)-143(miR-143)の機能を検討し、miR-143と患者予後の関係を調べた。マイクロRNA(miRNA)マイクロアレイ分析により、非スキルス型よりもスキルス型GCにおいてより高レベルで発現するいくつかのmiRNAを同定し、miR-143の発現が高かった。in situハイブリダイゼーションおよび定量的RT-PCR分析では、miR-143は間質線維芽細胞に発現していたが、癌細胞によっては発現しなかった。間質細胞では、miR-143が転換増殖因子-β/SMADシグナル伝達の活性化を介して、正常胃線維芽細胞および癌関連線維芽細胞におけるコラーゲンIII型の発現を増強した。GCにおけるmiR-143高発現は癌特異的死亡率の悪化と関連していた。多変量解析では、miR-143が独立した予後因子であった。GC細胞株を5-aza-2'-deoxycytidineで処理するとmiR-143の発現が元に戻った。miR-143前駆体は癌細胞の浸潤を阻害した。

  • Successful resection of esophageal carcinoma with aberrant right subclavian artery using video-assisted thoracoscopic surgery: report of two cases. Reviewed

    Kasashima H, Kubo N, Ohira M, Sakurai K, Toyokawa T, Tanaka H, Muguruma K, Shibutani M, Yamazoe S, Kimura K, Nagahara H, Amano R, Ohtani H, Yashiro M, Maeda K, Hirakawa K

    Anticancer research   34 ( 2 )   899 - 904   2014.02( ISSN:0250-7005

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    PubMed

  • Stromal Fibroblasts Mediate Extracellular Matrix Remodeling and Invasion of Scirrhous Gastric Carcinoma Cells Reviewed

    Yamaguchi Hideki, Yoshida Nachi, Takanashi Miho, Ito Yuumi, Fukami Kiyoko, Yanagihara Kazuyoshi, Yashiro Masakazu, Sakai Ryuichi

    PLOS ONE   9 ( 1 )   e85485   2014.01( ISSN:1932-6203

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    DOI: 10.1371/journal.pone.0085485

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  • Gastric Metastasis From Renal Cell Carcinoma With Gastrointestinal Bleeding: A Case Report and Review of the Literature Reviewed

    Katsunobu Sakurai, Kazuya Muguruma, Sadaaki Yamazoe, Kenjiro Kimura, Takahiro Toyokawa, Ryosuke Amano, Naoshi Kubo, Hiroaki Tanaka, Masakazu Yashiro, Masaichi Ohira, Kosei Hirakawa

    INTERNATIONAL SURGERY   99 ( 1 )   86 - 90   2014.01( ISSN:0020-8868

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    A 61-year-old man presented to our hospital with hypercalcemia and elevated C reactive protein (CRP). Evaluation revealed renal cell carcinoma (RCC) with metastasis to lung, bone, and brain. He underwent partial resection of the right kidney and a left nephrectomy. Histopathologic findings of resected tumors were consistent with clear cell RCC. Whole-brain irradiation was performed for management of brain metastasis. Postoperatively, he was treated with molecularly targeted therapy using a mammalian target of rapamycin inhibitor. Approximately 14 months later, he suffered an episode of upper gastrointestinal bleeding with secondary anemia and melena. Upper gastrointestinal endoscopy revealed a distinctly protruding lesion in the gastric body. Biopsy of the gastric lesion showed metastatic clear cell RCC. He underwent partial gastrectomy. His postoperative course was uneventful. However, 4 months after surgery, he died from brain metastasis. Metastatic RCC to the stomach, although rare, should be suspected in any patient with a history of RCC who presents with gastrointestinal symptoms.

    DOI: 10.9738/INTSURG-D-13-00115.1

    PubMed

  • Portal Vein Stenting to Treat Portal Vein Stenosis in a Patient With Malignant Tumor and Gastrointestinal Bleeding Reviewed

    Katsunobu Sakurai, Ryosuke Amano, Akira Yamamoto, Norifumi Nishida, Shinya Matsutani, Keiichiro Hirata, Kenjiro Kimura, Kazuya Muguruma, Takahiro Toyokawa, Naoshi Kubo, Hiroaki Tanaka, Masakazu Yashiro, Masaichi Ohira, Kosei Hirakawa

    INTERNATIONAL SURGERY   99 ( 1 )   91 - 5   2014.01( ISSN:0020-8868

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    This report describes the successful use of portal venous stent placement for a patient with recurrent melena secondary to jejunal varices that developed after subtotal stomach preserved pancreatoduodenectomy (SSPPD). A 67-year-old man was admitted to our hospital with tarry stool and severe anemia at 2 years after SSPPD for carcinoma of the head of the pancreas. Abdominal computed tomography examination showed severe stenosis of the extrahepatic portal vein caused by local recurrence and showed an intensely enhanced jejunal wall at the choledochojejunostomy. Gastrointestinal bleeding scintigraphy also revealed active bleeding near the choledochojejunostomy. Based on these findings, jejunal varices resulting from portal vein stenosis were suspected as the cause of the melena. Portal vein stenting and balloon dilation was performed via the ileocecal vein after laparotomy. Coiling of the jejunal varices and sclerotherapy of the dilate postgastric vein with 5% ethanolamine oleate with iopamidol was performed. After portal stent placement, the patient was able to lead a normal life without gastrointestinal hemorrhage. However, he died 7 months later due to liver metastasis.

    DOI: 10.9738/INTSURG-D-13-00128.1

    PubMed

  • Portal Vein Stenting to Treat Portal Vein Stenosis in a Patient With Malignant Tumor and Gastrointestinal Bleeding Reviewed

    Sakurai Katsunobu, Amano Ryosuke, Yamamoto Akira, Nishida Norifumi, Matsutani Shinya, Hirata Keiichiro, Kimura Kenjiro, Muguruma Kazuya, Toyokawa Takahiro, Kubo Naoshi, Tanaka Hiroaki, Yashiro Masakazu, Ohira Masaichi, Hirakawa Kosei

    INTERNATIONAL SURGERY   99 ( 1 )   91 - 95   2014( ISSN:0020-8868

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    DOI: 10.9738/INTSURG-D-13-00128.1

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  • Gastric Metastasis From Renal Cell Carcinoma With Gastrointestinal Bleeding: A Case Report and Review of the Literature Reviewed

    Sakurai Katsunobu, Muguruma Kazuya, Yamazoe Sadaaki, Kimura Kenjiro, Toyokawa Takahiro, Amano Ryosuke, Kubo Naoshi, Tanaka Hiroaki, Yashiro Masakazu, Ohira Masaichi, Hirakawa Kosei

    INTERNATIONAL SURGERY   99 ( 1 )   86 - 90   2014( ISSN:0020-8868

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    DOI: 10.9738/INTSURG-D-13-00115.1

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  • Significance of prostaglandin D2 on gastric cancer Reviewed

    Fukuoka Tatsunari, Sakurai Katsunobu, Toyokawa Takahiro, Kubo Naoshi, Tanaka Hiroaki, Muguruma Kazuya, Ohira Masaichi, Hirakawa Kosei, Yashiro Masakazu, Kazashima Hiroaki, Masuda Go, Go Yukie, Kinoshita Haruhito, Watanabe Mao, Morisaki Tamami, Okita Yoshihiro

    Japanese Society for Molecular Tumor Marker Research, Japan Journal of Molecular Tumor Marker Research   29 ( 0 )   36 - 37   2014

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    DOI: 10.11241/jsmtmr.29.36

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  • Determination of gastric cancer stem cell markers by comparative proteomics analysis Reviewed

    Morisaki Tamami, Tanaka Hiroaki, Muguruma Kazuya, Ohira Masaichi, Wanibuchi Hideki, Hirakawa Kosei, Yashiro Masakazu, Kakehashi Anna, Kasashima Hiroaki, Masuda Go, Kinoshita Haruhito, Sakurai Katsunobu, Toyokawa Takahiro, Kubo Naoshi

    Japanese Society for Molecular Tumor Marker Research, Japan Journal of Molecular Tumor Marker Research   29 ( 0 )   40 - 41   2014

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    DOI: 10.11241/jsmtmr.29.40

    CiNii Article

  • Comparative Proteomics Analysis of Gastric Cancer Stem Cells Reviewed

    Tamami Morisaki, Masakazu Yashiro, Anna Kakehashi, Azusa Inagaki, Haruhito Kinoshita, Tatsunari Fukuoka, Hiroaki Kasashima, Go Masuda, Katsunobu Sakurai, Naoshi Kubo, Kazuya Muguruma, Masaichi Ohira, Hideki Wanibuchi, Kosei Hirakawa

    PLOS ONE   9 ( 11 )   e110736   2014( ISSN:1932-6203

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    Cancer stem cells (CSCs) are responsible for cancer progression, metastasis, and recurrence. To date, the specific markers of CSCs remain undiscovered. The aim of this study was to identify novel biomarkers of gastric CSCs for clinical diagnosis using proteomics technology. CSC-like SP cells, OCUM-12/SP cells, OCUM-2MD3/SP cells, and their parent OCUM-12 cells and OCUM-2MD3 cells were used in this study. Protein lysates from each cell line were analyzed using QSTAR Elite Liquid Chromatography with Tandem Mass Spectrometry, coupled with isobaric tags for relative and absolute quantitation technology. Candidate proteins detected by proteomics technology were validated by immunohistochemical analysis of 300 gastric cancers. Based on the results of LC-MS/MS, eight proteins, including RBBP6, GLG1, VPS13A, DCTPP1, HSPA9, HSPA4, ALDOA, and KRT18, were up-regulated in both OCUM-12/SP cells and OCUM-2MD3/SP cells when compared to their corresponding parent cells. RT-PCR analysis indicated that the expression level of RBBP6, HSPA4, DCTPP1, HSPA9, VPS13A, ALDOA, GLG1, and CK18 was high in OCUM-12/SP and OCUM-2MD3/SP, in compared with the control of parent OCUM-12 and OCUM-2MD3. These proteins were significantly associated with advanced invasion depth, lymph node metastasis, distant metastasis, or advanced clinical stage. RBBP6, DCTPP1, HSPA4, and ALDOA expression in particular were significantly associated with a poor prognosis in the 300 gastric cancer patients. RBBP6 was determined to be an independent prognostic factor. The motility-stimulating ability of OCUM-12/SP cells and OCUM-2MD3/SP cells was inhibited by RBBP6 siRNA. These findings might suggest that the eight proteins, RBBP6, GLG1, VPS13A, DCTPP1, HSPA9, HSPA4, ALDOA, and KRT18, utilizing comparative proteomics analysis, were perceived to be potential CSC markers of gastric cancer. Of the eight candidate proteins, RBBP6 was suggested to be a promising prognostic biomarker and a therapeutic target for gastric cancer.

    DOI: 10.1371/journal.pone.0110736

    PubMed

  • Determination of gastric cancer stem cell markers by comparative proteomics analysis Reviewed

    Morisaki Tamami, Yashiro Masakazu, Kakehashi Anna, Kasashima Hiroaki, Masuda Go, Kinoshita Haruhito, Sakurai Katsunobu, Toyokawa Takahiro, Kubo Naoshi, Tanaka Hiroaki, Muguruma Kazuya, Ohira Masaichi, Wanibuchi Hideki, Hirakawa Kosei

    Japan Journal of Molecular Tumor Marker Research   29 ( 0 )   40 - 41   2014( eISSN:24338575

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    DOI: 10.11241/jsmtmr.29.40

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    Other URL: http://search.jamas.or.jp/link/ui/2015388694

  • Significance of prostaglandin D2 on gastric cancer Reviewed

    Fukuoka Tatsunari, Yashiro Masakazu, Kazashima Hiroaki, Masuda Go, Go Yukie, Kinoshita Haruhito, Watanabe Mao, Morisaki Tamami, Okita Yoshihiro, Sakurai Katsunobu, Toyokawa Takahiro, Kubo Naoshi, Tanaka Hiroaki, Muguruma Kazuya, Ohira Masaichi, Hirakawa Kosei

    Japan Journal of Molecular Tumor Marker Research   29 ( 0 )   36 - 37   2014( eISSN:24338575

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    DOI: 10.11241/jsmtmr.29.36

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  • Stromal Fibroblasts Mediate Extracellular Matrix Remodeling and Invasion of Scirrhous Gastric Carcinoma Cells Reviewed

    Hideki Yamaguchi, Nachi Yoshida, Miho Takanashi, Yuumi Ito, Kiyoko Fukami, Kazuyoshi Yanagihara, Masakazu Yashiro, Ryuichi Sakai

    PLOS ONE   9 ( 1 )   e85485   2014( ISSN:1932-6203

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    Scirrhous gastric carcinoma (SGC) has the worst prognosis of all gastric cancers, owing to its rapid expansion by invasion and frequent peritoneal dissemination. Due to the increased proliferation of stromal fibroblasts (SFs) that occurs within SGC lesions and the peritoneal metastatic sites, SFs have been proposed to support the progression of this disease. However, the biological and molecular basis and the pathological role of the intercellular interaction between SGC cells and SFs remain largely unknown. In this study, we investigated the role of SFs in the invasion of the extracellular matrix (ECM) by SGC cells. When SGC cells were cocultured with SFs derived from SGC tissue on three-dimensional (3D) Matrigel, they were attracted together to form large cellular aggregates that invaded within the Matrigel. Time-lapse imaging revealed that this process was associated with extensive contraction and remodeling of the ECM. Immunofluorescence and biochemical analysis showed that SGC cells stimulate phosphorylation of myosin light chain and actomyosin-mediated mechanical remodeling of the ECM by SFs. By utilizing this assay system for inhibitor library screening, we have identified several inhibitors that potently suppress the cooperation between SGC cells and SFs to form the invasive structures. Among them, a Src inhibitor dasatinib impaired the interaction between SGC cells and SFs both in vitro and in vivo and effectively blocked peritoneal dissemination of SGC cells. These results indicate that SFs mediate mechanical remodeling of the ECM by SGC cells, thereby promoting invasion and peritoneal dissemination of SGC.

    DOI: 10.1371/journal.pone.0085485

    PubMed

  • New molecular staging with G-factors (VEGF-C and Reg IV) by supplementing TNM classification in colorectal cancers Reviewed

    Sawada Tetsuji, Yashiro Masakazu, Sentani Kazuhiro, Oue Naohide, Yasui Wataru, Miyazaki Kohji, Kai Keita, Fujita Hideto, Nakamura Keishi, Maeda Kiyoshi, Kakeji Yoshihiro, Natsugoe Shoji, Shirabe Ken, Nomura Sachiyo, Shimada Yutaka, Tomita Naohiro, Hirakawa Kosei, Maehara Yoshihiko

    ONCOLOGY REPORTS   30 ( 6 )   2609 - 2616   2013.12( ISSN:1021-335X

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    DOI: 10.3892/or.2013.2787

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  • Heregulin induces resistance to lapatinib-mediated growth inhibition of HER2-amplified cancer cells Reviewed

    Sato Yuji, Yashiro Masakazu, Takakura Nobuyuki

    CANCER SCIENCE   104 ( 12 )   1618 - 1625   2013.12( ISSN:1347-9032

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    DOI: 10.1111/cas.12290

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  • ヘレグリンはHER2増幅性癌細胞のラパチニブ仲介増殖阻害に対する耐性を誘導する(Heregulin induces resistance to lapatinib-mediated growth inhibition of HER2-amplified cancer cells) Reviewed

    Sato Yuji, Yashiro Masakazu, Takakura Nobuyuki

    John Wiley & Sons Australia, Ltd Cancer Science   104 ( 12 )   1618 - 1625   2013.12( ISSN:1347-9032

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    胃癌および胃食道接合部癌において、HER3とHER4の特異的リガンドであるヘレグリン1(HRG1)が、HER2とEGF受容体の両者を標的化するチロシンキナーゼ阻害剤ラパチニブに対する耐性を付与する機構を、細胞系を用いたin vitro実験で調べた。HER2増幅性の胃癌および胃食道接合部癌はラパチニブに高い感受性を示した。HRG1をラパチニブと併用すると癌細胞は細胞周期停止やアポトーシスから救済されたが、HER3をsiRNAでダウンレギュレートするとHER2増幅性癌細胞のラパチニブ感受性が回復した。免疫ブロット解析からラパチニブ存在下においてHRG1はHER3とAKTを活性化し、活性化はHER2の残余活性により仲介されていた。HRG1が付与するラパチニブ耐性はPI3K/mTOR阻害剤やHER2の完全阻害により低下した。以上によりHRG1によるラパチニブ耐性にはHER3とAKT情報伝達の再活性化が関与し、HER2の残余活性に依存することが示された。

  • New molecular staging with G-factors (VEGF-C and Reg IV) by supplementing TNM classification in colorectal cancers Reviewed

    Tetsuji Sawada, Masakazu Yashiro, Kazuhiro Sentani, Naohide Oue, Wataru Yasui, Kohji Miyazaki, Keita Kai, Hideto Fujita, Keishi Nakamura, Kiyoshi Maeda, Yoshihiro Kakeji, Shoji Natsugoe, Ken Shirabe, Sachiyo Nomura, Yutaka Shimada, Naohiro Tomita, Kosei Hirakawa, Yoshihiko Maehara

    Oncology Reports   30 ( 6 )   2609 - 16   2013.12( ISSN:1021-335X

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    Staging classification of colorectal cancers is performed by the UICC/TNM classification system, which is the global gold standard. However, we often experience in clinical practice that there are considerable differences in prognoses between patients who have the same classification particularly in stage II and III cancers. The aim of this study was to propose a new TNM-G classification to predict prognosis and recurrence by supplementing the conventional TNM classification. A total of 220 cases of colorectal cancer, including 77 at stage II and 143 at stage III, were registered from four independent facilities. Immunohistochemical staining for 7 molecules, such as p53, vascular endothelial growth factor (VEGF)-A, VEGF-C, regenerating islet-derived family, member 4 (Reg IV), olfactomedin 4, Claudin-18 and matrix metalloproteinase-7 (MMP-7), was performed to investigate the correlation between clinicopathological factors and expression of each molecule. Based on the results, no significant correlation was observed between the immunostaining expression of these 7 factors and recurrence in total colorectal cancer. Recurrence in stage II (77 cases) was significantly higher in cases positive for Reg IV expression (P=0.042). On analysis of overall survival (OS) and disease-free survival (DFS), VEGF-C and Reg IV expression had a correlation with poor prognosis, therefore, these factors were selected and applied to G-factor classifications so that cases negative for both could be classified as G0, cases positive for either of the factors could be classified as G1, and cases positive for both factors could be classified as G2. While no significant correlation was observed in the recurrence rates between G0 and G2, OS and DFS in stage II cases were significantly poorer for G2 cases in comparison with G0 or G1 cases. The survival curves of OS and DFS in stage II G2 were similar to that of stage III cases. According to these results, prognosis of VEGF-C/Reg IV both positive G2 cases in stage II colorectal cancer was found to be almost equal to the poor survival in stage III cases, and the advancement of one stage up migration based on G-factors may be supposed to be highly feasible for clinical application. In conclusion, the combination of VEGF-C and Reg IV may be a promising factor for clinical staging to supplement the classical TNM classification system, and it may suggest a good indication of adjuvant chemotherapy for G2 cases in stage II colorectal cancers.

    DOI: 10.3892/or.2013.2787

    PubMed

  • Heregulin induces resistance to lapatinib-mediated growth inhibition of HER2-amplified cancer cells Reviewed

    Yuji Sato, Masakazu Yashiro, Nobuyuki Takakura

    Cancer Science   104 ( 12 )   1618 - 1625   2013.12( ISSN:1347-9032

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    Human epidermal growth factor receptor 2 (HER2) amplification occurs in approximately 20% of gastric and gastroesophageal junction cancers in the United States and European Union. Lapatinib, a dual HER2 and epidermal growth factor receptor tyrosine kinase inhibitor, has demonstrated clinical efficacy in HER2-amplified cancer cells. However, several studies have shown that some cytokines can mediate resistance to lapatinib using their receptor tyrosine kinase (RTK) pathways. One of these, Heregulin1 (HRG1), can confer resistance to lapatinib-mediated growth inhibition in HER2-amplified breast cancer cells, but the underlying mechanisms remain unknown. Here, we investigated whether and how HRG1 causes resistance to lapatinib in gastric and gastroesophageal junction cancers in vitro. HER2-amplified gastric and gastroesophageal junction cancer cell lines were highly sensitive to lapatinib. Exposure to HRG1 together with lapatinib rescued cells from lapatinib-induced cell cycle arrest and apoptosis. Downregulation of HER3 with siRNA in the presence of HRG1 re-sensitized HER2-amplified cancer cells to lapatinib. Immunoblotting analysis indicated that HRG1 re-activated HER3 and AKT in the presence of lapatinib, which persisted for at least 72 h. Activation of HER3 and downstream AKT was mediated by residual activity of HER2. HRG1-mediated resistance could be reduced by PI3K/mTOR inhibitors or by complete inhibition of HER2. Thus, we conclude that HRG1 mediates resistance to lapatinib through HER3 and AKT activation, and that this depends on residual HER2 activity. Lapatinib in combination with anti-PI3K therapies or more potent HER2 inhibitors would improve the efficacy and avoid the emergence of resistant cells. © 2013 Japanese Cancer Association.

    DOI: 10.1111/cas.12290

    PubMed

  • ヘレグリンはHER2増幅性癌細胞のラパチニブ仲介増殖阻害に対する耐性を誘導する(Heregulin induces resistance to lapatinib-mediated growth inhibition of HER2-amplified cancer cells) Reviewed

    Sato Yuji, Yashiro Masakazu, Takakura Nobuyuki

    Cancer Science   104 ( 12 )   1618 - 1625   2013.12( ISSN:1347-9032

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    胃癌および胃食道接合部癌において、HER3とHER4の特異的リガンドであるヘレグリン1(HRG1)が、HER2とEGF受容体の両者を標的化するチロシンキナーゼ阻害剤ラパチニブに対する耐性を付与する機構を、細胞系を用いたin vitro実験で調べた。HER2増幅性の胃癌および胃食道接合部癌はラパチニブに高い感受性を示した。HRG1をラパチニブと併用すると癌細胞は細胞周期停止やアポトーシスから救済されたが、HER3をsiRNAでダウンレギュレートするとHER2増幅性癌細胞のラパチニブ感受性が回復した。免疫ブロット解析からラパチニブ存在下においてHRG1はHER3とAKTを活性化し、活性化はHER2の残余活性により仲介されていた。HRG1が付与するラパチニブ耐性はPI3K/mTOR阻害剤やHER2の完全阻害により低下した。以上によりHRG1によるラパチニブ耐性にはHER3とAKT情報伝達の再活性化が関与し、HER2の残余活性に依存することが示された。

  • A c-Met inhibitor increases the chemosensitivity of cancer stem cells to the irinotecan in gastric carcinoma Reviewed

    Yashiro M., Nishii T., Hasegawa T., Matsuzaki T., Morisaki T., Fukuoka T., Hirakawa K.

    BRITISH JOURNAL OF CANCER   109 ( 10 )   2619 - 2628   2013.11( ISSN:0007-0920

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    DOI: 10.1038/bjc.2013.638

  • A c-Met inhibitor increases the chemosensitivity of cancer stem cells to the irinotecan in gastric carcinoma. Reviewed

    Yashiro M, Nishii T, Hasegawa T, Matsuzaki T, Morisaki T, Fukuoka T, Hirakawa K

    British journal of cancer   109 ( 10 )   2619 - 28   2013.11( ISSN:0007-0920

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    DOI: 10.1038/bjc.2013.638

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  • Binding of the Sialic Acid-binding Lectin, Siglec-9, to the Membrane Mucin, MUC1, Induces Recruitment of beta-Catenin and Subsequent Cell Growth Reviewed

    Tanida Shuhei, Akita Kaoru, Ishida Akiko, Mori Yugo, Toda Munetoyo, Inoue Mizue, Ohta Mariko, Yashiro Masakazu, Sawada Tetsuji, Hirakawa Kosei, Nakada Hiroshi

    JOURNAL OF BIOLOGICAL CHEMISTRY   288 ( 44 )   31842 - 31852   2013.11( ISSN:0021-9258

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    DOI: 10.1074/jbc.M113.471318

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  • 食道癌の化学放射線療法中に放射線性肺臓炎を来した5例の治療経験 Reviewed

    櫻井 克宣, 久保 尚士, 渋谷 雅常, 山添 定明, 木村 健二郎, 永原 央, 豊川 貴弘, 天野 良亮, 田中 浩明, 六車 一哉, 大谷 博, 八代 正和, 前田 清, 大平 雅一, 平川 弘聖

    (株)癌と化学療法社 癌と化学療法   40 ( 12 )   2139 - 2142   2013.11( ISSN:0385-0684

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    食道癌に対する化学放射線療法(chemoradiotherapy:CRT)は、局所進行症例だけでなく切除可能例にも有効な治療法である。CRTに関連した有害事象の一つである放射線性肺臓炎(radiation pneumonitis:RP)は、重篤な経過をたどることがあり注意を要する。今回われわれは、CRT後に発症し、重症化した5例のRPを経験したので報告する。患者はすべて男性で、平均年齢は72(66〜76)歳であった。食道癌の病期はStage I、II、IVaがそれぞれ1、2、2例であった。総放射線照射量の平均値は51.8(43.4〜61.4)Gyであった。初発症状は発熱4例、血中CRP高値が1例で、咳嗽や呼吸困難などの呼吸器症状で発症したものは認めなかった。診断時期は放射線終了から平均6.8(1〜18)日で、全例胸部CT検査にてRPと診断された。5例中4例は人工呼吸器による集中治療が必要となり、全例にステロイドパルス治療が施行された。2例は軽快したが、3例は死亡した(1例は多臓器不全、2例は呼吸不全で死亡)。食道癌に対するCRT施行中に発熱やCRPの上昇を認めた場合、RPを念頭に置くことが重要である。(著者抄録)

  • [Successful treatment of locally advanced squamous cell carcinoma of the esophagus by combination chemotherapy with 5-fluorouracil plus nedaplatin following tracheal stent tube placement-a case report]. Reviewed

    Nishimura J, Kubo N, Lee T, Shinto O, Sakurai K, Toyokawa T, Tanaka H, Muguruma K, Shibutani M, Yamazoe S, Nagahara H, Kimura K, Amano R, Ohtani H, Yashiro M, Maeda K, Ohira M, Hirakawa K

    Gan to kagaku ryoho. Cancer & chemotherapy   40 ( 12 )   2112 - 4   2013.11( ISSN:0385-0684

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    PubMed

  • [Five cases of severe radiation pneumonitis after chemoradiotherapy for esophageal cancer]. Reviewed

    Sakurai K, Kubo N, Shibutani M, Yamazoe S, Kimura K, Nagahara H, Toyokawa T, Amano R, Tanaka H, Muguruma K, Ohtani H, Yashiro M, Maeda K, Ohira M, Hirakawa K

    Gan to kagaku ryoho. Cancer & chemotherapy   40 ( 12 )   2139 - 42   2013.11( ISSN:0385-0684

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    PubMed

  • Glyoxalase 1 as a candidate for indicating the metastatic potential of SN12C human renal cell carcinoma cell clones Reviewed

    Tanaka Toshiyuki, Kuramitsu Yasuhiro, Wang Yufeng, Baron Byron, Kitagawa Takao, Tokuda Kazuhiro, Hirakawa Kosei, Yashiro Masakazu, Naito Seiji, Nakamura Kazuyuki

    ONCOLOGY REPORTS   30 ( 5 )   2365 - 2370   2013.11( ISSN:1021-335X

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    DOI: 10.3892/or.2013.2699

    PubMed

  • Tumor budding and E-cadherin expression are useful predictors of nodal involvement in T1 esophageal squamous cell carcinoma. Reviewed

    Nakagawa Y, Ohira M, Kubo N, Yamashita Y, Sakurai K, Toyokawa T, Tanaka H, Muguruma K, Shibutani M, Yamazoe S, Kimura K, Nagahara H, Amano R, Ohtani H, Yashiro M, Maeda K, Hirakawa K

    Anticancer research   33 ( 11 )   5023 - 9   2013.11( ISSN:0250-7005

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    PubMed

  • Tumor Budding and E-Cadherin Expression Are Useful Predictors of Nodal Involvement in T1 Esophageal Squamous Cell Carcinoma Reviewed

    Nakagawa Yasuo, Ohira Masaichi, Kubo Naoshi, Yamashita Yoshito, Sakurai Katsunobu, Toyokawa Takahiro, Tanaka Hiroaki, Muguruma Kazuya, Shibutani Masatsune, Yamazoe Sadaaki, Kimura Kenjiro, Nagahara Hisashi, Amano Ryosuke, Ohtani Hiroshi, Yashiro Masakazu, Maeda Kiyoshi, Hirakawa Kosei

    ANTICANCER RESEARCH   33 ( 11 )   5023 - 5029   2013.11( ISSN:0250-7005

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  • 気管ステント留置後に5-FU/Nedaplatinが著効した切除不能進行食道癌の1例 Reviewed

    西村 潤也, 久保 尚士, 李 友浩, 神藤 理, 櫻井 克宣, 豊川 貴弘, 田中 浩明, 六車 一哉, 渋谷 雅常, 山添 定明, 永原 央, 木村 健二郎, 天野 良亮, 大谷 博, 八代 正和, 前田 清, 大平 雅一, 平川 弘聖

    (株)癌と化学療法社 癌と化学療法   40 ( 12 )   2112 - 2114   2013.11( ISSN:0385-0684

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    症例は68歳、男性。主訴は嗄声、呼吸困難。上部消化管内視鏡検査にて門歯から30cmの胸部中部食道に1/4周性の3型腫瘍を認め、生検で中分化型扁平上皮癌であった。胸部CT検査では腫大した左反回神経周囲リンパ節が気管を圧排し、著明な気道狭窄を伴っていた。以上から、cT4(106recL-trachea)、N2(101L、106recL、106recR)、M0、Stage IVaの切除不能進行食道癌と診断した。呼吸困難を改善するために、気管ステント(spiral Z stent:直径18mm、長径80mm)を留置し、自覚症状が改善した後に、5-fluorouracil(5-FU)とnedaplatinを併用した化学療法を開始した。治療開始後、原発巣と転移リンパ節の著明な縮小を認めた。同療法を19コース施行したが、目立った有害事象は認めず、2年6ヵ月間、完全奏効(complete response:CR)を維持している。気道狭窄を伴う局所進行食道癌に対し気管ステント留置後に化学療法を行い、CRを得られたまれな症例を経験したので報告する。(著者抄録)

  • Glyoxalase 1 as a candidate for indicating the metastatic potential of SN12C human renal cell carcinoma cell clones Reviewed

    Toshiyuki Tanaka, Yasuhiro Kuramitsu, Yufeng Wang, Byron Baron, Takao Kitagawa, Kazuhiro Tokuda, Kosei Hirakawa, Masakazu Yashiro, Seiji Naito, Kazuyuki Nakamura

    Oncology Reports   30 ( 5 )   2365 - 2370   2013.11( ISSN:1021-335X

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    Three clones with differential metastatic potential were established from the parental SN12C human renal cell carcinoma (HRCC). We previously reported that in the two high metastatic SN12C clones, two isoforms of ubiquitin carboxyl-terminal hydrolase isozyme L1 (UCH-L1) showed decreased expression by using two-dimensional electrophoresis (2-DE) covering a pH range (pH 3.0-10.0) followed by liquid chromatography-tandem mass spectrometry. However, in the case of the low metastatic clone, the spot volume for UCH-L1 was almost the same as for the parental SN12C. In the present study, we found one protein spot which was correlated with the metastatic potential of SN12C clones by using 2-DE over a narrow pH range (pH 4.0-7.0). The protein glyoxalase 1 (GLO1) appeared to be directly proportional to the metastatic potential of the SN12C clones. GLO1 was the only protein which consistently varied according to the metastatic potentials of SN12C clones. GLO1 was increased in high metastatic cell lines by western blot analysis. These findings suggest that GLO1 is associated with the metastatic potential of SN12C HRCC clones. We expanded our experimental range to include clones of scirrhous gastric cancer cell lines (OCUM-2M, OCUM-2D and OCUM-2MLN) and similar results were obtained, thereby further strengthening our original findings.

    DOI: 10.3892/or.2013.2699

    PubMed

  • [Five cases of severe radiation pneumonitis after chemoradiotherapy for esophageal cancer]. Reviewed

    Sakurai K, Kubo N, Shibutani M, Yamazoe S, Kimura K, Nagahara H, Toyokawa T, Amano R, Tanaka H, Muguruma K, Ohtani H, Yashiro M, Maeda K, Ohira M, Hirakawa K

    Gan to kagaku ryoho. Cancer & chemotherapy   40 ( 12 )   2139 - 42   2013.11( ISSN:0385-0684

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    PubMed

  • Tumor budding and E-cadherin expression are useful predictors of nodal involvement in T1 esophageal squamous cell carcinoma. Reviewed

    Nakagawa Y, Ohira M, Kubo N, Yamashita Y, Sakurai K, Toyokawa T, Tanaka H, Muguruma K, Shibutani M, Yamazoe S, Kimura K, Nagahara H, Amano R, Ohtani H, Yashiro M, Maeda K, Hirakawa K

    Anticancer research   33 ( 11 )   5023 - 9   2013.11( ISSN:0250-7005

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    PubMed

  • Tumor budding and E-cadherin expression are useful predictors of nodal involvement in T1 esophageal squamous cell carcinoma Reviewed

    Yasuo Nakagawa, Masaichi Ohira, Naoshi Kubo, Yoshito Yamashita, Katsunobu Sakurai, Takahiro Toyokawa, Hiroaki Tanaka, Kazuya Muguruma, Masatsune Shibutani, Sadaaki Yamazoe, Kenjiro Kimura, Hisashi Nagahara, Ryosuke Amano, Hiroshi Ohtani, Masakazu Yashiro, Kiyoshi Maeda, Kosei Hirakawa

    Anticancer Research   33 ( 11 )   5023 - 5030   2013.11( ISSN:0250-7005

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    Background: Endoscopic treatment has been increasingly used for T1 esophageal squamous cell carcinoma (ESCC). However, this therapy is sometimes incomplete if the depth of the T1 primary tumor reaches the muscularis mucosae or submucosal layer because these tumors have a relatively high incidence of lymph node metastasis. However, to our knowledge, no previous reports on the prediction of nodal metastasis determined by evaluating primary tumor specimens of patients with ESCC are available. Patients and Methods: A total of 55 patients with T1 ESCC invading as deep as the submucosal layer who underwent curative esophagectomy were examined. We investigated the significance of the immunohistochemical staining of Vascular endothelial growth factor-C (VEGF-C) and E-cadherin in the primary tumor and Tumor budding for prediction of nodal metastasis. Results: Metastasis to the regional lymph nodes was observed in 26 cases (47.3%) in this setting. VEGF-C expression and reduced E-Cadherin expression in the primary tumor was observed in 32 (58.1%) and 38 cases (69.1%), respectively. High-grade tumor budding was observed in 29 cases (52.7%). E-cadherin expression and tumor budding were closely correlated with nodal metastasis (p=0.04 and &lt
    0.01 respectively), whereas VEGF-C expression tended to correlate with lymph node metastasis (p=0.06). In addition, high-grade tumor budding was significantly correlated (p&lt
    0.01) with reduced E-cadherin expression. The accuracy of tumor budding and E-cadherin expression for nodal metastasis were 67.3% and 65.4% respectively, comparable with the one of lymphatic involvement (63%). Tumor budding (p&lt
    0.01), but not E-cadherin and VEGF-C expression, was significantly correlated with poor survival. Conclusion: After the endoscopic treatment, additional therapy, such as surgery or chemoradiotherapy, may be required if reduced E-cadherin expression and high-grade tumor budding are observed in primary tumor specimen.

    PubMed

  • Binding of the Sialic Acid-binding Lectin, Siglec-9, to the Membrane Mucin, MUC1, Induces Recruitment of beta-Catenin and Subsequent Cell Growth Reviewed

    Shuhei Tanida, Kaoru Akita, Akiko Ishida, Yugo Mori, Munetoyo Toda, Mizue Inoue, Mariko Ohta, Masakazu Yashiro, Tetsuji Sawada, Kosei Hirakawa, Hiroshi Nakada

    JOURNAL OF BIOLOGICAL CHEMISTRY   288 ( 44 )   31842 - 31852   2013.11( ISSN:0021-9258 ( eISSN:1083-351X

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    Because MUC1 carries a variety of sialoglycans that are possibly recognized by the siglec family, we examined MUC1-binding siglecs and found that Siglec-9 prominently bound to MUC1. An immunochemical study showed that Siglec-9-positive immune cells were associated with MUC1-positive cells in human colon, pancreas, and breast tumor tissues. We investigated whether or not this interaction has any functional implications for MUC1-expressing cells. When mouse 3T3 fibroblast cells and a human colon cancer cell line, HCT116, stably transfected with MUC1cDNA were ligated with recombinant soluble Siglec-9, beta-catenin was recruited to the MUC1 C-terminal domain, which was enhanced on stimulation with soluble Siglec-9 in dose-and time-dependent manners. A co-culture model of MUC1-expressing cells and Siglec-9-expressing cells mimicking the interaction between MUC1-expressing malignant cells, and Siglec-9-expressing immune cells in a tumor microenvironment was designed. Brief co-incubation of Siglec-9-expressing HEK293 cells, but not mock HEK293 cells, with MUC1-expressing cells similarly enhanced the recruitment of beta-catenin to the MUC1 C-terminal domain. In addition, treatment of MUC1-expressing cells with neuraminidase almost completely abolished the effect of Siglec-9 on MUC1-mediated signaling. The recruited beta-catenin was thereafter transported to the nucleus, leading to cell growth. These findings suggest that Siglec-9 expressed on immune cells may play a role as a potential counterreceptor for MUC1 and that this signaling may be another MUC1-mediated pathway and function in parallel with a growth factor-dependent pathway.

    DOI: 10.1074/jbc.M113.471318

    PubMed

  • [Successful treatment of locally advanced squamous cell carcinoma of the esophagus by combination chemotherapy with 5-fluorouracil plus nedaplatin following tracheal stent tube placement-a case report]. Reviewed

    Nishimura J, Kubo N, Lee T, Shinto O, Sakurai K, Toyokawa T, Tanaka H, Muguruma K, Shibutani M, Yamazoe S, Nagahara H, Kimura K, Amano R, Ohtani H, Yashiro M, Maeda K, Ohira M, Hirakawa K

    Gan to kagaku ryoho. Cancer & chemotherapy   40 ( 12 )   2112 - 2114   2013.11( ISSN:0385-0684

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    PubMed

  • [Successful treatment of locally advanced squamous cell carcinoma of the esophagus by combination chemotherapy with 5-fluorouracil plus nedaplatin following tracheal stent tube placement-a case report]. Reviewed

    Nishimura J, Kubo N, Lee T, Shinto O, Sakurai K, Toyokawa T, Tanaka H, Muguruma K, Shibutani M, Yamazoe S, Nagahara H, Kimura K, Amano R, Ohtani H, Yashiro M, Maeda K, Ohira M, Hirakawa K

    Gan to kagaku ryoho. Cancer & chemotherapy   40 ( 12 )   2112 - 4   2013.11( ISSN:0385-0684

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    PubMed

  • [Five cases of severe radiation pneumonitis after chemoradiotherapy for esophageal cancer]. Reviewed

    Sakurai K, Kubo N, Shibutani M, Yamazoe S, Kimura K, Nagahara H, Toyokawa T, Amano R, Tanaka H, Muguruma K, Ohtani H, Yashiro M, Maeda K, Ohira M, Hirakawa K

    Gan to kagaku ryoho. Cancer & chemotherapy   40 ( 12 )   2139 - 2142   2013.11( ISSN:0385-0684

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    PubMed

  • 気管ステント留置後に5-FU/Nedaplatinが著効した切除不能進行食道癌の1例 Reviewed

    西村 潤也, 久保 尚士, 李 友浩, 神藤 理, 櫻井 克宣, 豊川 貴弘, 田中 浩明, 六車 一哉, 渋谷 雅常, 山添 定明, 永原 央, 木村 健二郎, 天野 良亮, 大谷 博, 八代 正和, 前田 清, 大平 雅一, 平川 弘聖

    癌と化学療法   40 ( 12 )   2112 - 2114   2013.11( ISSN:0385-0684

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    症例は68歳、男性。主訴は嗄声、呼吸困難。上部消化管内視鏡検査にて門歯から30cmの胸部中部食道に1/4周性の3型腫瘍を認め、生検で中分化型扁平上皮癌であった。胸部CT検査では腫大した左反回神経周囲リンパ節が気管を圧排し、著明な気道狭窄を伴っていた。以上から、cT4(106recL-trachea)、N2(101L、106recL、106recR)、M0、Stage IVaの切除不能進行食道癌と診断した。呼吸困難を改善するために、気管ステント(spiral Z stent:直径18mm、長径80mm)を留置し、自覚症状が改善した後に、5-fluorouracil(5-FU)とnedaplatinを併用した化学療法を開始した。治療開始後、原発巣と転移リンパ節の著明な縮小を認めた。同療法を19コース施行したが、目立った有害事象は認めず、2年6ヵ月間、完全奏効(complete response:CR)を維持している。気道狭窄を伴う局所進行食道癌に対し気管ステント留置後に化学療法を行い、CRを得られたまれな症例を経験したので報告する。(著者抄録)

  • 食道癌の化学放射線療法中に放射線性肺臓炎を来した5例の治療経験 Reviewed

    櫻井 克宣, 久保 尚士, 渋谷 雅常, 山添 定明, 木村 健二郎, 永原 央, 豊川 貴弘, 天野 良亮, 田中 浩明, 六車 一哉, 大谷 博, 八代 正和, 前田 清, 大平 雅一, 平川 弘聖

    癌と化学療法   40 ( 12 )   2139 - 2142   2013.11( ISSN:0385-0684

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    食道癌に対する化学放射線療法(chemoradiotherapy:CRT)は、局所進行症例だけでなく切除可能例にも有効な治療法である。CRTに関連した有害事象の一つである放射線性肺臓炎(radiation pneumonitis:RP)は、重篤な経過をたどることがあり注意を要する。今回われわれは、CRT後に発症し、重症化した5例のRPを経験したので報告する。患者はすべて男性で、平均年齢は72(66~76)歳であった。食道癌の病期はStage I、II、IVaがそれぞれ1、2、2例であった。総放射線照射量の平均値は51.8(43.4~61.4)Gyであった。初発症状は発熱4例、血中CRP高値が1例で、咳嗽や呼吸困難などの呼吸器症状で発症したものは認めなかった。診断時期は放射線終了から平均6.8(1~18)日で、全例胸部CT検査にてRPと診断された。5例中4例は人工呼吸器による集中治療が必要となり、全例にステロイドパルス治療が施行された。2例は軽快したが、3例は死亡した(1例は多臓器不全、2例は呼吸不全で死亡)。食道癌に対するCRT施行中に発熱やCRPの上昇を認めた場合、RPを念頭に置くことが重要である。(著者抄録)

  • Port Site Metastasis After Laparoscopic-Assisted Distal Gastrectomy (LADG) Reviewed

    Katsunobu Sakurai, Hiroaki Tanaka, Tomohiro Lee, Kazuya Muguruma, Naoshi Kubo, Masakazu Yashiro, Masaichi Ohira, Kosei Hirakawa

    INTERNATIONAL SURGERY   98 ( 4 )   363 - 6   2013.10( ISSN:0020-8868

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    This report describes a case of port site metastasis after laparoscopic gastrectomy for gastric cancer. A 57-year-old man with clinical cTNM stage II (T2 N0 M0) gastric cancer was admitted to our hospital. After administration of an oral fluoropyrimidine drug (S-1) for 2 weeks, he underwent laparoscopy-assisted distal gastrectomy (LADG). On hematoxylin and eosin staining, the pTNM stage was IA (T1b N0 M0). Eighteen months later, the patient developed a subcutaneous metastasis at the trocar site. A second operation was performed, and the abdominal wall mass was resected. The histological finding confirmed a diagnosis of metastatic gastric carcinoma. Immunohistochemical analysis revealed micrometastasis in fat tissue adjacent to the lymph node near the left gastric artery. Surgeons should be aware that port site metastasis can occur in patients undergoing LADG for gastric cancer with lymphatic micrometastasis, which is undetectable on routine hematoxylin and eosin staining.

    DOI: 10.9738/INTSURG-D-13-00049.1

    PubMed

  • プロスタグランジンD2による胃癌細胞に対する増殖抑制機序の解明 Reviewed

    福岡 達成, 八代 正和, 木下 春人, 渡邊 真央, 森崎 珠実, 大北 仁裕, 青松 直撥, 長谷川 毅, 平川 俊基, 李 友浩, 櫻井 克宣, 豊川 貴弘, 久保 尚士, 田中 浩明, 六車 一哉, 大平 雅一, 平川 弘聖

    日本消化器外科学会雑誌   46 ( Suppl.2 )   351 - 351   2013.10( ISSN:0386-9768 ( eISSN:1348-9372

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  • 胃癌浸潤CD11b+樹状細胞と制御性T細胞(Treg)の臨床的病理学的検討(Tumor infiltrating regulatory T cells were correlated with CD11b+ dendritic cells in patients with gastric cancer) Reviewed

    大北 仁裕, 田中 浩明, 渡邊 真央, 木村 健二郎, 永原 央, 天野 良亮, 久保 尚士, 六車 一哉, 大谷 博, 八代 正和, 前田 清, 大平 雅一, 平川 弘聖

    日本癌学会総会記事   72回   364 - 364   2013.10( ISSN:0546-0476

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  • α1-酸性糖蛋白によるパクリタキセルの活性阻害とバイオケミカルモジュレーション Reviewed

    大畠 慶直, 伏田 幸夫, 柄田 智也, 木下 淳, 尾山 勝信, 岡本 浩一, 中村 慶史, 田島 秀浩, 高村 博之, 二宮 致, 北川 裕久, 藤村 隆, 八代 正和, 平川 弘聖, 太田 哲生

    日本癌治療学会誌   48 ( 3 )   1327 - 1327   2013.09( ISSN:0021-4671

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  • 胃癌組織内に浸潤する制御性T細胞と樹状細胞の関係 Reviewed

    大北 仁裕, 田中 浩明, 櫻井 克宣, 山添 定明, 木村 健二郎, 永原 央, 豊川 貴弘, 天野 良亮, 久保 尚士, 六車 一哉, 大谷 博, 八代 正和, 前田 清, 大平 雅一, 平川 弘聖

    日本癌治療学会誌   48 ( 3 )   2271 - 2271   2013.09( ISSN:0021-4671

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  • プロスタグランジンD2による胃癌抑制効果 Reviewed

    福岡 達成, 八代 正和, 笠島 裕明, 増田 剛, 呉 幸枝, 木下 春人, 渡辺 真央, 森崎 珠実, 大北 仁裕, 櫻井 克宣, 豊川 貴弘, 久保 尚士, 田中 浩明, 六車 一哉, 大平 雅一, 平川 弘聖

    日本分子腫瘍マーカー研究会プログラム・講演抄録   33回   62 - 63   2013.09

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  • IGF-1 receptor and IGF binding protein-3 might predict prognosis of patients with resectable pancreatic cancer Reviewed

    Hirakawa Toshiki, Yashiro Masakazu, Murata Akihiro, Hirata Keiichiro, Kimura Kenjiro, Amano Ryosuke, Yamada Nobuya, Nakata Bunzo, Hirakawa Kosei

    BMC CANCER   13   392   2013.08( ISSN:1471-2407

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    DOI: 10.1186/1471-2407-13-392

    PubMed

  • IGF-1 receptor and IGF binding protein-3 might predict prognosis of patients with resectable pancreatic cancer Reviewed

    Toshiki Hirakawa, Masakazu Yashiro, Akihiro Murata, Keiichiro Hirata, Kenjiro Kimura, Ryosuke Amano, Nobuya Yamada, Bunzo Nakata, Kosei Hirakawa

    BMC CANCER   13   392   2013.08( ISSN:1471-2407

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    Background: The present study aimed to elucidate the clinicopathologic role of insulin-like growth factor-1 receptor (IGF1R) and IGF binding protein-3 (IGFBP3) in patients with pancreatic cancer. The function of IGFBP3 is controversial, because both inhibition and facilitation of the action of IGF as well as IGF-independent effects have been reported. In this study, IGF1R and IGFBP3 expression was examined, and their potential roles as prognostic markers in patients with pancreatic cancer were evaluated.
    Methods: Clinicopathological features of 122 patients with curatively resected pancreatic cancer were retrospectively reviewed, and expression of IGF1R and IGFBP3 was immunohistochemically analyzed.
    Results: Expression of IGF1R and IGFBP3 was observed in 50 (41.0%) and 37 (30.3%) patients, respectively. IGF1R expression was significantly associated with histological grade (p = 0.037). IGFBP3 expression had a significant association with tumor location (p = 0.023), and a significant inverse association with venous invasion (p = 0.037). Tumors with IGF1R-positive and IGFBP3-negative expression (n = 32) were significantly frequently Stage II and III (p = 0.011). The prognosis for IGF1R positive patients was significantly poorer than that for IGF1R negative patients (p = 0.0181). IGFBP3 protein expression did not correlate significantly with patient survival. The subset of patients with both positive IGF1R and negative IGFBP3 had worse overall survival (8.8 months versus 12.6 months, respectively, p &lt; 0.001).
    Conclusion: IGF1R signaling might be associated with tumor aggressiveness, and IGFBP3 might show antiproliferative effects in pancreatic cancer. Both high IGF1R expression and low IGFBP3 expression represent useful prognostic markers for patients with curatively resected pancreatic cancer.

    DOI: 10.1186/1471-2407-13-392

    PubMed

  • SPan-1 Is a Useful Prognostic Marker for Patients with Stage IV Gastric Cancer Who Underwent Palliative Gastrectomy: A Retrospective Multivariate Study Reviewed

    Kubo Naoshi, Ohira Masaichi, Sakurai Katsunobu, Toyokawa Takahiro, Tanaka Hiroaki, Muguruma Kazuya, Nagahara Hisashi, Kimura Kenjiro, Noda Eiji, Amano Ryosuke, Yamada Nobuya, Yashiro Masakazu, Maeda Kiyoshi, Sawada Tetsuji, Hirakawa Kosei

    WORLD JOURNAL OF SURGERY   37 ( 7 )   1681 - 1687   2013.07( ISSN:0364-2313

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    DOI: 10.1007/s00268-013-2016-7

    PubMed

  • MUC1 and HER2 might be associated with invasive phenotype of intraductal papillary mucinous neoplasm Reviewed

    Go Ohira, Kenjiro Kimura, Nobuya Yamada, Ryosuke Amano, Bunzo Nakata, Yosuke Doi, Akihiro Murata, Masakazu Yashiro, Sayaka Tanaka, Masahiko Ohsawa, Kenichi Wakasa, Kosei Hirakawa

    Hepato-Gastroenterology   60 ( 125 )   1067 - 1072   2013.07( ISSN:0172-6390

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    Background/Aims: The purpose of this study was to clarify the biomarkers which distinguish invasive intraductal papillary mucinous neoplasms (IPMNs) from non-invasive IPMNs. Methodology: In-tumor specimens from sixty patients with IPMNs (42 non-invasive IPMNs and 18 invasive IPMNs) who underwent surgical resection at our institute, were analyzed for correlation between the immunohistochemical expression levels of MUC1, MUC2, MUC4, MUC5AC, p53, VEGFR2, HER2, and HER3. Results: The 5-year survival rate was 100% in non-invasive IPMNs, while that of invasive IPMNs was only 36.5%. MUC1, MUC4, HER2 and HER3 were significantly associated with invasive IPMNs in univariate analysis. Multivariate analysis revealed that MUC1 and HER2 were significantly associated with invasive IPMNs. The 5-year survival of IPMN patients with either MUC1-positive and/or HER2-positive (54.5%) is significantly poorer than that of IPMN patients with MUC1 negative and HER2 negative (100%). Conclusions: MUC1 and HER2 might be closely associated with invasive phenotype of IPMNs. © H.G.E. Update Medical Publishing S.A.

    DOI: 10.5754/hge121268

    PubMed

  • SPan-1 is a useful prognostic marker for patients with stage IV gastric cancer who underwent palliative gastrectomy: A retrospective multivariate study Reviewed

    Naoshi Kubo, Masaichi Ohira, Katsunobu Sakurai, Takahiro Toyokawa, Hiroaki Tanaka, Kazuya Muguruma, Hisashi Nagahara, Kenjiro Kimura, Eiji Noda, Ryosuke Amano, Nobuya Yamada, Masakazu Yashiro, Kiyoshi Maeda, Tetsuji Sawada, Kosei Hirakawa

    World Journal of Surgery   37 ( 7 )   1681 - 7   2013.07( ISSN:0364-2313

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    Background: We retrospectively investigated prognostic factors to be used in selecting the patients with stage IV gastric cancer (GC) who have an unfavorable prognosis after palliative gastrectomy. Methods: A total of 146 GC patients at stage IV who had undergone palliative gastrectomy were enrolled. Various clinicopathological parameters were evaluated for prognosis. Results: Surgical morbidity and hospital mortality occurred in 35 (23.9 %) and 4 (2.7 %) patients, respectively. The overall 5-year survival rate and the median survival time were 11.2 % and 13.2 months, respectively. Of the 146 patients, 64 had uncomfortable symptoms associated with GC and 76 had no such symptoms. Of the 64 patients with uncomfortable symptoms, 60 (93.7 %) experienced relief of these symptoms after palliative surgery. Multivariate analysis for patients without uncomfortable symptoms associated with GC revealed that the number of incurable factors and serum SPan-1 level were independent prognostic factors. Conclusions: Patients with stage IV GC who had multiple incurable factors and a high level of serum SPan-1 might not be candidates for palliative gastrectomy for the purpose of prognostic benefit. © 2013 Société Internationale de Chirurgie.

    DOI: 10.1007/s00268-013-2016-7

    PubMed

  • Prognostic predictive values of gemcitabine sensitivity-related gene products for unresectable or recurrent biliary tract cancer treated with gemcitabine alone Reviewed

    Murata Akihiro, Amano Ryosuke, Yamada Nobuya, Kimura Kenjiro, Yashiro Masakazu, Nakata Bunzo, Hirakawa Kosei

    WORLD JOURNAL OF SURGICAL ONCOLOGY   11   117   2013.05( ISSN:1477-7819

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    DOI: 10.1186/1477-7819-11-117

    PubMed

  • Prognostic predictive values of gemcitabine sensitivity-related gene products for unresectable or recurrent biliary tract cancer treated with gemcitabine alone Reviewed

    Akihiro Murata, Ryosuke Amano, Nobuya Yamada, Kenjiro Kimura, Masakazu Yashiro, Bunzo Nakata, Kosei Hirakawa

    World Journal of Surgical Oncology   11   117   2013.05( ISSN:1477-7819

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    Background: Gemcitabine is a pyrimidine nucleoside analog that is a commonly used chemotherapeutic agent for unresectable or recurrent biliary tract cancer (BTC). Several molecules involved in gemcitabine metabolism, including human equilibrative nucleoside transporter (hENT1), deoxycytidine kinase (dCK), and ribonucleotide reductase subunit M1 (RRM1), have been investigated as predictive biomarkers of gemcitabine efficacy, mostly in pancreatic cancer. The aim of this study is to clarify which biomarker is the most reliable among hENT1, dCK, and RRM1 to predict survival in patients with advanced BTC treated with gemcitabine alone.Methods: The analysis was performed on samples from 28 patients with unresectable or recurrent BTC who were treated with gemcitabine alone as first-line therapy. The starting date of overall survival (OS) and progression-free survival (PFS) was defined as the date of first treatment with gemcitabine. Intratumoral hENT1, dCK, and RRM1 expressions were examined by immunohistochemistry.Results: The expressions of hENT1, dCK, and RRM1 had no significant relationships with age, gender, primary tumor site, recurrence/unresectable, or histological type. Among the three molecules, only hENT1 expression was a significant factor affecting OS and PFS in univariate analysis
    OS was 11.4 months for high hENT1 expression versus 5.7 months for low, P = 0.0057
    PFS was 7.7 months for high versus 2.5 months for low, P = 0.0065. Multivariate analyses also identified hENT1 expression as an independent predictive factor for OS.Conclusions: hENT1 is the most reliable predictive marker of survival in patients with advanced BTC treated with gemcitabine. © 2013 Murata et al.
    licensee BioMed Central Ltd.

    DOI: 10.1186/1477-7819-11-117

    PubMed

  • Hypoxia Stimulates the EMT of Gastric Cancer Cells through Autocrine TGF beta Signaling Reviewed

    Matsuoka Junko, Yashiro Masakazu, Doi Yosuke, Fuyuhiro Yuhiko, Kato Yukihiro, Shinto Osamu, Noda Satoru, Kashiwagi Shinichiro, Aomatsu Naoki, Hirakawa Toshiki, Hasegawa Tsuyoshi, Shimizu Kiyoshi, Shimizu Toshiyuki, Miwa Atsushi, Yamada Nobuya, Sawada Tetsuji, Hirakawa Kosei

    PLOS ONE   8 ( 5 )   e62310   2013.05( ISSN:1932-6203

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    DOI: 10.1371/journal.pone.0062310

    PubMed

  • Association of MHC Class I Expression and Lymph Node Metastasis of Gastric Carcinoma Reviewed

    Yoshii Mami, Tanaka Hiroaki, Ohira Masaichi, Muguruma Kazuya, Sakurai Katsunobu, Kubo Naoshi, Yashiro Masakazu, Sawada Tetsuji, Hirakawa Kosei

    HEPATO-GASTROENTEROLOGY   60 ( 123 )   611 - 615   2013.05( ISSN:0172-6390

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    DOI: 10.5754/hge12433

    PubMed

  • Association of MHC class I expression and lymph node metastasis of gastric carcinoma Reviewed

    Mami Yoshii, Hiroaki Tanaka, Masaichi Ohira, Kazuya Muguruma, Katsunobu Sakurai, Naoshi Kubo, Masakazu Yashiro, Tetsuji Sawada, Kosei Hirakawa

    Hepato-Gastroenterology   60 ( 123 )   611 - 5   2013.05( ISSN:0172-6390

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    Background/Aims: HLA gene encodes MHC, which could represent a common mechanism for enhanced antitumor immune response through T-cell cytotoxicity. Loss of HLA class I expression has been considered to be an important prognostic factor in many malignancies. We investigated the impact of HLA class I expression on lymph node metastasis in gastric carcinoma. Methodology: We examined HLA class I expression in clinical samples from 349 patients by immunohistochemistry and compared primary lesions and metastatic lymph nodes. We analyzed the expression of HLA class I antigen in gastric cancer cell lines using flow-cytometry and HLA-A typed these cell lines using PCR. Results: HLA class I expression was down-regulated in metastatic lymph nodes compared with its expression in primary lesion. Patients with negative expression showed a significantly poorer prognosis. We observed down-regulation of HLA class I antigen in OCUM-2MLN cell line, which has a high potential for metastasizing to lymph node. PCR-SBT analysis indicated LOH of HLA-A gene in OCUM-2MLN. Conclusions: We showed that HLA class I expression was abrogated in tumor cells that had metastasized to lymph nodes. We further suggest that loss of HLA class I due to LOH was associated with lymph node metastasis. © H.G.E. Update Medical Publishing S.A.

    DOI: 10.5754/hge12433

    PubMed

  • Antitumor effect of prostaglandin D2 by peroxisome proliferator-activated receptor gamma (PPAR gamma)-dependent pathway in gastric carcinoma Reviewed

    Fukuoka Tatsunari, Yashiro Masakazu, Takeda Hiroshi, Maruyama Takayuki, Kinoshita Haruhito, Morisaki Tamammi, Hasegawa Tsuyoshi, Hirakawa Toshiki, Aomatsu Naoki, Sakurai Katsunobu, Kimura Kenjiro, Nagahara Hisashi, Toyokawa Takahiro, Amano Ryosuke, Noda Eiji, Kubo Naoshi, Tanaka Hiroaki, Muguruma Kazuya, Otani Hiroshi, Maeda Kiyoshi, Ohira Masaichi, Hirakawa Kosei

    CANCER RESEARCH   73 ( 8 )   2013.04( ISSN:0008-5472

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    DOI: 10.1158/1538-7445.AM2013-3995

  • Design and synthesis of a series of alpha-benzyl phenylpropanoic acid-type peroxisome proliferator-activated receptor (PPAR) gamma partial agonists with improved aqueous solubility Reviewed

    Ohashi Masao, Oyama Takuji, Putranto Endy Widya, Waku Tsuyoshi, Nobusada Hiromi, Kataoka Ken, Matsuno Kenji, Yashiro Masakazu, Morikawa Kosuke, Huh Nam-ho, Miyachi Hiroyuki

    BIOORGANIC & MEDICINAL CHEMISTRY   21 ( 8 )   2319 - 2332   2013.04( ISSN:0968-0896

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    DOI: 10.1016/j.bmc.2013.02.003

    PubMed

  • Significance of CXCR4/SDF-1 axis expression in gastric cancer under hypoxic enviroment Reviewed

    Kinoshita Haruhito, Yashiro Masakazu, Morisaki Tamami, Fukuoka Tatsunari, Hasegawa Tsuyoshi, Hirakawa Toshiki, Aomatsu Naoki, Sakurai Katsunobu, Kimura Kenjiro, Nagahara Hisashi, Toyokawa Takahiro, Amano Ryosuke, Noda Eiji, Kubo Naoshi, Tanaka Hiroaki, Muguruma Kazuya, Otani Hiroshi, Maeda Kiyoshi, Ohira Masaichi, Hirakawa Kosei

    CANCER RESEARCH   73 ( 8 )   2013.04( ISSN:0008-5472

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  • Design and synthesis of a series of α-benzyl phenylpropanoic acid-type peroxisome proliferator-activated receptor (PPAR) gamma partial agonists with improved aqueous solubility Reviewed

    Masao Ohashi, Takuji Oyama, Endy Widya Putranto, Tsuyoshi Waku, Hiromi Nobusada, Ken Kataoka, Kenji Matsuno, Masakazu Yashiro, Kosuke Morikawa, Nam-Ho Huh, Hiroyuki Miyachi

    Bioorganic and Medicinal Chemistry   21 ( 8 )   2319 - 2332   2013.04( ISSN:0968-0896

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    In the continuing study directed toward the development of peroxisome proliferator-activated receptor gamma (hPPARγ) agonist, we attempted to improve the water solubility of our previously developed hPPARγ-selective agonist 3, which is insufficiently soluble for practical use, by employing two strategies: introducing substituents to reduce its molecular planarity and decreasing its hydrophobicity via replacement of the adamantyl group with a heteroaromatic ring. The first approach proved ineffective, but the second was productive. Here, we report the design and synthesis of a series of α-benzyl phenylpropanoic acid-type hPPARγ partial agonists with improved aqueous solubility. Among them, we selected (R)-7j, which activates hPPARγ to the extent of about 65% of the maximum observed with a full agonist, for further evaluation. The ligand-binding mode and the reason for the partial-agonistic activity are discussed based on X-ray-determined structure of the complex of hPPARγ ligand-binding domain (LBD) and (R)-7j with previously reported ligand-LDB structures. Preliminal apoptotic effect of (R)-7j against human scirrhous gastric cancer cell line OCUM-2MD3 is also described. © 2013 Elsevier Ltd. All rights reserved.

    DOI: 10.1016/j.bmc.2013.02.003

    PubMed

  • Expression of E-cadherin and KRAS mutation may serve as biomarkers of cetuximab-based therapy in metastatic colorectal cancer Reviewed

    Nakamoto Kentaro, Nagahara Hisashi, Maeda Kiyoshi, Noda Eiji, Inoue Toru, Yashiro Masakazu, Nishiguchi Yukio, Ohira Masaichi, Hirakawa Kosei

    ONCOLOGY LETTERS   5 ( 4 )   1295 - 1300   2013.04( ISSN:1792-1074

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    DOI: 10.3892/ol.2013.1187

    PubMed

  • Successful resection of esophageal cancer with right aortic arch by video-assisted thoracoscopic surgery: a case report. Reviewed

    Kubo N, Ohira M, Lee T, Sakurai K, Toyokawa T, Tanaka H, Muguruma K, Kimura K, Nagahara H, Noda E, Amano R, Ohtani H, Yamashita Y, Yashiro M, Maeda K, Hirakawa K

    Anticancer research   33 ( 4 )   1635 - 40   2013.04( ISSN:0250-7005

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  • Successful Resection of Esophageal Cancer with Right Aortic Arch by Video-Assisted Thoracoscopic Surgery: A Case Report Reviewed

    Kubo Naoshi, Ohira Masaichi, Lee Tomohiro, Sakurai Katsunobu, Toyokawa Takahiro, Tanaka Hiroaki, Muguruma Kazuya, Kimura Kenjiro, Nagahara Hisashi, Noda Eiji, Amano Ryosuke, Ohtani Hiroshi, Yamashita Yoshito, Yashiro Masakazu, Maeda Kiyoshi, Hirakawa Kosei

    ANTICANCER RESEARCH   33 ( 4 )   1635 - 1640   2013.04( ISSN:0250-7005

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  • Expression of E-cadherin and KRAS mutation may serve as biomarkers of cetuximab-based therapy in metastatic colorectal cancer Reviewed

    Kentaro Nakamoto, Hisashi Nagahara, Kiyoshi Maeda, Eiji Noda, Toru Inoue, Masakazu Yashiro, Yukio Nishiguchi, Masaichi Ohira, Kosei Hirakawa

    Oncology Letters   5 ( 4 )   1295 - 1300   2013.04( ISSN:1792-1074

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    Cetuximab (Cmab), a chimeric monoclonal antibody for targeting the epidermal growth factor receptor, has become one of the standard treatments for metastatic colorectal cancer (mCRC). However, only a small proportion of patients respond to Cmab, and it has been reported that KRAS mutation is a negative biomarker of response to Cmab therapy. The aim of this study was to detect additional biomarkers of response to Cmab therapy in patients with mCRC. We evaluated the effects of Cmab therapy in 36 patients with mCRC according to the Response Evaluation Criteria in Solid Tumors, and classified patients who achieved complete response, partial response or stable disease as responders, and patients who achieved progressive disease as non-responders. We retrospectively examined the difference between the two groups using KRAS analysis and immunohistochemistry to determine the expression of E-cadherin, p53 and Ki67. Nineteen patients were responders, while 17 patients were non-responders. KRAS status and expression of E-cadherin were significantly correlated with the effect of Cmab therapy. Moreover, the expression of E-cadherin was significantly correlated with the effect of Cmab therapy in KRAS wild-type patients. In KRAS mutanttype patients, the expression of E-cadherin did not significantly correlate with the effect of Cmab therapy, but all responders with KRAS mutant-type tumors expressed E-cadherin. Our results indicate that the expression of E-cadherin detected by immunohistochemistry may be a positive predictor of Cmabbased therapy in mCRC, and that a combination of E-cadherin immunohistochemistry and KRAS analysis may be a more sensitive biomarker than KRAS analysis alone.

    DOI: 10.3892/ol.2013.1187

    PubMed

  • Successful Resection of Esophageal Cancer with Right Aortic Arch by Video-Assisted Thoracoscopic Surgery: A Case Report Reviewed

    Naoshi Kubo, Masaichi Ohira, Tomohiro Lee, Katsunobu Sakurai, Takahiro Toyokawa, Hiroaki Tanaka, Kazuya Muguruma, Kenjiro Kimura, Hisashi Nagahara, Eiji Noda, Ryosuke Amano, Hiroshi Ohtani, Yoshito Yamashita, Masakazu Yashiro, Kiyoshi Maeda, Kosei Hirakawa

    ANTICANCER RESEARCH   33 ( 4 )   1635 - 1640   2013.04( ISSN:0250-7005

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    The right aortic arch (RAA) forms a vascular ring, encircling both the esophagus and trachea. We herein report a case of thoracic esophageal cancer with RAA successfully resected using video-assited thoracoscopic surgery (VATS). A 64-year-old man who presented with a complaint of abdominal pain, was admitted to our hospital. Further examinations revealed gall stones and multiple superficial esophageal carcinomas. Three-dimensional computed tomographic images showed RAA and aortic diverticulum. The trachea and esophagus were completely encircled by the RAA, the aortic diverticulum and the pulmonary artery. We successfully and safely performed VATS esophagectomy for esophageal cancer accompanied with RAA. To the best of our knowledge, this report is the first case for which VATS esophagectomy for esophageal cancer, accompanied with RAA, was carried out. Marking of the left recurrent laryngeal nerve with colored tape at the cervical part of the surgery made it easy to identify it during the thoracoscopic part of the surgery.

    PubMed

  • Successful resection of esophageal cancer with right aortic arch by video-assisted thoracoscopic surgery: a case report. Reviewed

    Kubo N, Ohira M, Lee T, Sakurai K, Toyokawa T, Tanaka H, Muguruma K, Kimura K, Nagahara H, Noda E, Amano R, Ohtani H, Yamashita Y, Yashiro M, Maeda K, Hirakawa K

    Anticancer research   33 ( 4 )   1635 - 40   2013.04( ISSN:0250-7005

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    PubMed

  • PS-004-2 乳癌術前化学療法効果予測因子としての癌幹細胞マーカーの意義(PS ポスターセッション,第113回日本外科学会定期学術集会) Reviewed

    青松 直撥, 八代 正和, 木下 春人, 森崎 珠実, 福岡 達成, 平川 俊基, 長谷川 毅, 柏木 伸一郎, 高島 勉, 川尻 成美, 小野田 尚佳, 石川 哲郎, 平川 弘聖

    一般社団法人日本外科学会 日本外科学会雑誌   114 ( 2 )   2013.03( ISSN:18801129

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  • VF-061-3 安全確実な膵空腸吻合を目指した手技の工夫(VF ビデオフォーラム,第113回日本外科学会定期学術集会) Reviewed

    天野 良亮, 木村 健二郎, 山田 靖哉, 平田 啓一郎, 村田 哲洋, 永原 央, 野田 英児, 久保 尚士, 田中 浩明, 六車 一哉, 八代 正和, 前田 清, 仲田 文造, 大平 雅一, 平川 弘聖

    一般社団法人日本外科学会 日本外科学会雑誌   114 ( 2 )   2013.03( ISSN:18801129

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  • PS-305-4 4型スキルス胃癌腹膜播種転移の分子機序と新たな治療戦略(PS ポスターセッション,第113回日本外科学会定期学術集会) Reviewed

    福岡 達成, 八代 正和, 野田 論, 木下 春人, 大北 仁裕, 森崎 珠実, 青松 直擾, 長谷川 毅, 平川 俊基, 吉井 真美, 李 友浩, 櫻井 克宣, 天野 良亮, 野田 英児, 久保 尚士, 田中 浩明, 六車 一哉, 前田 清, 澤田 鉄二, 大平 雅一, 平川 弘聖

    一般社団法人日本外科学会 日本外科学会雑誌   114 ( 2 )   2013.03( ISSN:18801129

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  • PS-304-3 胃癌腹膜播種細胞株に対するヒストン脱アセチル化酵素阻害剤バルプロ酸ナトリウムの増殖抑制効果(PS ポスターセッション,第113回日本外科学会定期学術集会) Reviewed

    伏田 幸夫, 柄田 智也, 木下 淳, 尾山 勝信, 岡本 浩一, 中村 慶史, 田島 秀浩, 高村 博之, 二宮 致, 藤村 隆, 太田 哲生, 八代 正和, 平川 弘聖

    一般社団法人日本外科学会 日本外科学会雑誌   114 ( 2 )   2013.03( ISSN:18801129

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  • PS-115-3 膵癌における癌間質相互作用の役割とIGFシグナルの関与(PS ポスターセッション,第113回日本外科学会定期学術集会) Reviewed

    平川 俊基, 八代 正和, 木下 春人, 森崎 珠実, 福岡 達成, 長谷川 毅, 青松 直撲, 吉井 真美, 木村 健二郎, 永原 央, 天野 良亮, 野田 英児, 久保 尚士, 田中 浩明, 六車 一哉, 山田 靖哉, 前田 清, 大平 雅一, 平川 弘聖

    一般社団法人日本外科学会 日本外科学会雑誌   114 ( 2 )   2013.03( ISSN:18801129

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  • PS-057-4 胃癌癌性腹水・術中洗浄水及び細胞株におけるエクソソームmiRNAの発現解析(PS ポスターセッション,第113回日本外科学会定期学術集会) Reviewed

    徳久 元彦, 市川 靖史, 小坂 展慶, 落谷 孝広, 八代 正和, 平川 弘聖, 小坂 隆司, 小野 秀高, 秋山 浩利, 國埼 主税, 遠藤 格

    一般社団法人日本外科学会 日本外科学会雑誌   114 ( 2 )   2013.03( ISSN:18801129

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  • PS-051-6 スキルス胃癌細胞の増殖能におよぼす癌周囲微小環境の影響(PS ポスターセッション,第113回日本外科学会定期学術集会) Reviewed

    木下 春人, 八代 正和, 渡辺 真央, 大北 仁裕, 森崎 珠実, 福岡 達成, 青松 直擾, 長谷川 毅, 平川 俊基, 吉井 真美, 櫻井 克宣, 天野 良亮, 野田 英児, 久保 尚士, 田中 浩明, 六車 一哉, 山田 靖哉, 前田 清, 仲田 文造, 大平 雅一, 平川 弘聖

    一般社団法人日本外科学会 日本外科学会雑誌   114 ( 2 )   2013.03( ISSN:18801129

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  • PS-039-3 胸部食道癌患者に対する鏡視下食道切除術は術後肺合併症の発生を抑制するか(PS ポスターセッション,第113回日本外科学会定期学術集会) Reviewed

    大平 雅一, 久保 尚士, 李 友浩, 櫻井 克宣, 永原 央, 木村 健二郎, 野田 英児, 天野 良亮, 田中 浩明, 六車 一哉, 山下 好人, 八代 正和, 前田 清, 平川 弘聖

    一般社団法人日本外科学会 日本外科学会雑誌   114 ( 2 )   2013.03( ISSN:18801129

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  • PS-013-2 トリプルネガティブ乳癌における基礎的研究と新たな分子標的治療の可能性(PS ポスターセッション,第113回日本外科学会定期学術集会) Reviewed

    柏木 伸一郎, 八代 正和, 青松 直撥, 川尻 成美, 池田 克実, 高島 勉, 小川 佳成, 小野田 尚佳, 石川 哲郎, 平川 弘聖

    一般社団法人日本外科学会 日本外科学会雑誌   114 ( 2 )   2013.03( ISSN:18801129

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  • WS-4-2 スキルス胃がん幹細胞の特性(WS ワークショップ,第113回日本外科学会定期学術集会) Reviewed

    八代 正和, 長谷川 毅, 西居 孝文, 木下 春人, 森崎 珠実, 福岡 達成, 平川 俊基, 青松 直撥, 櫻井 克宣, 野田 英児, 天野 良亮, 久保 尚士, 田中 浩明, 六車 一哉, 前田 清

    一般社団法人日本外科学会 日本外科学会雑誌   114 ( 2 )   2013.03( ISSN:18801129

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  • YT-6-6(YRA) 進行再発胆道癌gemcitabine治療症例におけるhENT1,dCK発現の意義(YT Young Researcher Award & Traveler's Grant,第113回日本外科学会定期学術集会) Reviewed

    村田 哲洋, 天野 良亮, 平田 啓一郎, 木村 健二郎, 山田 靖哉, 仲田 文造, 永原 央, 野田 英児, 久保 尚士, 田中 浩明, 六車 一哉, 八代 正和, 前田 清, 大平 雅一, 石川 哲郎, 平川 弘聖

    一般社団法人日本外科学会 日本外科学会雑誌   114 ( 2 )   2013.03( ISSN:18801129

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  • YT-4-1(YRA) 胃癌幹細胞関連蛋白の同定と臨床的意義(YT Young Researcher Award & Traveler's Grant,第113回日本外科学会定期学術集会) Reviewed

    森崎 珠実, 八代 正和, 渡邊 真央, 大北 仁裕, 福岡 達成, 長谷川 毅, 吉井 真美, 櫻井 克宣, 久保 尚士, 田中 浩明, 六車 一哉, 大平 雅一, 梯 アンナ, 鰐渕 英機, 平川 弘聖

    一般社団法人日本外科学会 日本外科学会雑誌   114 ( 2 )   2013.03( ISSN:18801129

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  • WS-5-6 ニッチ線維芽細胞はTGF一βによってスキルス胃癌幹細胞の幹細胞性を維持する(WS ワークショップ,第113回日本外科学会定期学術集会) Reviewed

    長谷川 毅, 八代 正和, 木下 春人, 森崎 珠実, 福岡 達成, 平川 俊基, 青松 直撥, 吉井 真美, 櫻井 克宣, 豊川 貴弘, 野田 英児, 天野 良亮, 久保 尚士, 田中 浩明, 六車 一哉, 前田 清, 大平 雅一, 平川 弘聖

    一般社団法人日本外科学会 日本外科学会雑誌   114 ( 2 )   2013.03( ISSN:18801129

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  • PS-004-2 乳癌術前化学療法効果予測因子としての癌幹細胞マーカーの意義(PS ポスターセッション,第113回日本外科学会定期学術集会) Reviewed

    青松 直撥, 八代 正和, 木下 春人, 森崎 珠実, 福岡 達成, 平川 俊基, 長谷川 毅, 柏木 伸一郎, 高島 勉, 川尻 成美, 小野田 尚佳, 石川 哲郎, 平川 弘聖

    日本外科学会雑誌   114 ( 2 )   522   2013.03( ISSN:18801129

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  • YT-6-6(YRA) 進行再発胆道癌gemcitabine治療症例におけるhENT1,dCK発現の意義(YT Young Researcher Award & Traveler's Grant,第113回日本外科学会定期学術集会) Reviewed

    村田 哲洋, 天野 良亮, 平田 啓一郎, 木村 健二郎, 山田 靖哉, 仲田 文造, 永原 央, 野田 英児, 久保 尚士, 田中 浩明, 六車 一哉, 八代 正和, 前田 清, 大平 雅一, 石川 哲郎, 平川 弘聖

    日本外科学会雑誌   114 ( 2 )   405   2013.03( ISSN:18801129

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  • YT-4-1(YRA) 胃癌幹細胞関連蛋白の同定と臨床的意義(YT Young Researcher Award & Traveler's Grant,第113回日本外科学会定期学術集会) Reviewed

    森崎 珠実, 八代 正和, 渡邊 真央, 大北 仁裕, 福岡 達成, 長谷川 毅, 吉井 真美, 櫻井 克宣, 久保 尚士, 田中 浩明, 六車 一哉, 大平 雅一, 梯 アンナ, 鰐渕 英機, 平川 弘聖

    日本外科学会雑誌   114 ( 2 )   400   2013.03( ISSN:18801129

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  • WS-5-6 ニッチ線維芽細胞はTGF一βによってスキルス胃癌幹細胞の幹細胞性を維持する(WS ワークショップ,第113回日本外科学会定期学術集会) Reviewed

    長谷川 毅, 八代 正和, 木下 春人, 森崎 珠実, 福岡 達成, 平川 俊基, 青松 直撥, 吉井 真美, 櫻井 克宣, 豊川 貴弘, 野田 英児, 天野 良亮, 久保 尚士, 田中 浩明, 六車 一哉, 前田 清, 大平 雅一, 平川 弘聖

    日本外科学会雑誌   114 ( 2 )   297   2013.03( ISSN:18801129

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  • WS-4-2 スキルス胃がん幹細胞の特性(WS ワークショップ,第113回日本外科学会定期学術集会) Reviewed

    八代 正和, 長谷川 毅, 西居 孝文, 木下 春人, 森崎 珠実, 福岡 達成, 平川 俊基, 青松 直撥, 櫻井 克宣, 野田 英児, 天野 良亮, 久保 尚士, 田中 浩明, 六車 一哉, 前田 清

    日本外科学会雑誌   114 ( 2 )   292   2013.03( ISSN:18801129

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  • VF-061-3 安全確実な膵空腸吻合を目指した手技の工夫(VF ビデオフォーラム,第113回日本外科学会定期学術集会) Reviewed

    天野 良亮, 木村 健二郎, 山田 靖哉, 平田 啓一郎, 村田 哲洋, 永原 央, 野田 英児, 久保 尚士, 田中 浩明, 六車 一哉, 八代 正和, 前田 清, 仲田 文造, 大平 雅一, 平川 弘聖

    日本外科学会雑誌   114 ( 2 )   477   2013.03( ISSN:18801129

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  • PS-305-4 4型スキルス胃癌腹膜播種転移の分子機序と新たな治療戦略(PS ポスターセッション,第113回日本外科学会定期学術集会) Reviewed

    福岡 達成, 八代 正和, 野田 論, 木下 春人, 大北 仁裕, 森崎 珠実, 青松 直擾, 長谷川 毅, 平川 俊基, 吉井 真美, 李 友浩, 櫻井 克宣, 天野 良亮, 野田 英児, 久保 尚士, 田中 浩明, 六車 一哉, 前田 清, 澤田 鉄二, 大平 雅一, 平川 弘聖

    日本外科学会雑誌   114 ( 2 )   947   2013.03( ISSN:18801129

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  • PS-304-3 胃癌腹膜播種細胞株に対するヒストン脱アセチル化酵素阻害剤バルプロ酸ナトリウムの増殖抑制効果(PS ポスターセッション,第113回日本外科学会定期学術集会) Reviewed

    伏田 幸夫, 柄田 智也, 木下 淳, 尾山 勝信, 岡本 浩一, 中村 慶史, 田島 秀浩, 高村 博之, 二宮 致, 藤村 隆, 太田 哲生, 八代 正和, 平川 弘聖

    日本外科学会雑誌   114 ( 2 )   946   2013.03( ISSN:18801129

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  • PS-115-3 膵癌における癌間質相互作用の役割とIGFシグナルの関与(PS ポスターセッション,第113回日本外科学会定期学術集会) Reviewed

    平川 俊基, 八代 正和, 木下 春人, 森崎 珠実, 福岡 達成, 長谷川 毅, 青松 直撲, 吉井 真美, 木村 健二郎, 永原 央, 天野 良亮, 野田 英児, 久保 尚士, 田中 浩明, 六車 一哉, 山田 靖哉, 前田 清, 大平 雅一, 平川 弘聖

    日本外科学会雑誌   114 ( 2 )   680   2013.03( ISSN:18801129

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  • PS-057-4 胃癌癌性腹水・術中洗浄水及び細胞株におけるエクソソームmiRNAの発現解析(PS ポスターセッション,第113回日本外科学会定期学術集会) Reviewed

    徳久 元彦, 市川 靖史, 小坂 展慶, 落谷 孝広, 八代 正和, 平川 弘聖, 小坂 隆司, 小野 秀高, 秋山 浩利, 國埼 主税, 遠藤 格

    日本外科学会雑誌   114 ( 2 )   598   2013.03( ISSN:18801129

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  • PS-051-6 スキルス胃癌細胞の増殖能におよぼす癌周囲微小環境の影響(PS ポスターセッション,第113回日本外科学会定期学術集会) Reviewed

    木下 春人, 八代 正和, 渡辺 真央, 大北 仁裕, 森崎 珠実, 福岡 達成, 青松 直擾, 長谷川 毅, 平川 俊基, 吉井 真美, 櫻井 克宣, 天野 良亮, 野田 英児, 久保 尚士, 田中 浩明, 六車 一哉, 山田 靖哉, 前田 清, 仲田 文造, 大平 雅一, 平川 弘聖

    日本外科学会雑誌   114 ( 2 )   590   2013.03( ISSN:18801129

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  • PS-039-3 胸部食道癌患者に対する鏡視下食道切除術は術後肺合併症の発生を抑制するか(PS ポスターセッション,第113回日本外科学会定期学術集会) Reviewed

    大平 雅一, 久保 尚士, 李 友浩, 櫻井 克宣, 永原 央, 木村 健二郎, 野田 英児, 天野 良亮, 田中 浩明, 六車 一哉, 山下 好人, 八代 正和, 前田 清, 平川 弘聖

    日本外科学会雑誌   114 ( 2 )   571   2013.03( ISSN:18801129

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  • PS-013-2 トリプルネガティブ乳癌における基礎的研究と新たな分子標的治療の可能性(PS ポスターセッション,第113回日本外科学会定期学術集会) Reviewed

    柏木 伸一郎, 八代 正和, 青松 直撥, 川尻 成美, 池田 克実, 高島 勉, 小川 佳成, 小野田 尚佳, 石川 哲郎, 平川 弘聖

    日本外科学会雑誌   114 ( 2 )   535   2013.03( ISSN:18801129

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  • c-Kit expression as a prognostic molecular marker in patients with basal-like breast cancer Reviewed

    Kashiwagi S., Yashiro M., Takashima T., Aomatsu N., Kawajiri H., Ogawa Y., Onoda N., Ishikawa T., Wakasa K., Hirakawa K.

    BRITISH JOURNAL OF SURGERY   100 ( 4 )   490 - 496   2013.03( ISSN:0007-1323

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    DOI: 10.1002/bjs.9021

  • c-Kit expression as a prognostic molecular marker in patients with basal-like breast cancer. Reviewed

    Kashiwagi S, Yashiro M, Takashima T, Aomatsu N, Kawajiri H, Ogawa Y, Onoda N, Ishikawa T, Wakasa K, Hirakawa K

    The British journal of surgery   100 ( 4 )   490 - 6   2013.03( ISSN:0007-1323

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    DOI: 10.1002/bjs.9021

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  • 4型スキルス胃癌腹膜播種転移の分子機序と新たな治療戦略 Reviewed

    福岡 達成, 八代 正和, 野田 論, 木下 春人, 大北 仁裕, 森崎 珠実, 青松 直撥, 長谷川 毅, 平川 俊基, 吉井 真美, 李 友浩, 櫻井 克宣, 天野 良亮, 野田 英児, 久保 尚士, 田中 浩明, 六車 一哉, 前田 清, 澤田 鉄二, 大平 雅一, 平川 弘聖

    日本外科学会雑誌   114 ( 臨増2 )   947 - 947   2013.03( ISSN:0301-4894

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  • 胃癌腹膜播種細胞株に対するヒストン脱アセチル化酵素阻害剤バルプロ酸ナトリウムの増殖抑制効果 Reviewed

    伏田 幸夫, 柄田 智也, 木下 淳, 尾山 勝信, 岡本 浩一, 中村 慶史, 田島 秀浩, 高村 博之, 二宮 致, 藤村 隆, 太田 哲生, 八代 正和, 平川 弘聖

    日本外科学会雑誌   114 ( 臨増2 )   946 - 946   2013.03( ISSN:0301-4894

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  • 胃癌幹細胞関連蛋白の同定と臨床的意義 Reviewed

    森崎 珠実, 八代 正和, 渡邊 真央, 大北 仁裕, 福岡 達成, 長谷川 毅, 吉井 真美, 櫻井 克宣, 久保 尚士, 田中 浩明, 六車 一哉, 大平 雅一, 梯 アンナ, 鰐渕 英機, 平川 弘聖

    日本外科学会雑誌   114 ( 臨増2 )   400 - 400   2013.03( ISSN:0301-4894

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  • スキルス胃癌細胞の増殖能におよぼす癌周囲微小環境の影響 Reviewed

    木下 春人, 八代 正和, 渡辺 真央, 大北 仁裕, 森崎 珠実, 福岡 達成, 青松 直撥, 長谷川 毅, 平川 俊基, 吉井 真美, 櫻井 克宣, 天野 良亮, 野田 英児, 久保 尚士, 田中 浩明, 六車 一哉, 山田 靖哉, 前田 清, 仲田 文造, 大平 雅一, 平川 弘聖

    日本外科学会雑誌   114 ( 臨増2 )   590 - 590   2013.03( ISSN:0301-4894

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  • Locoregional recurrence after neoadjuvant chemotherapy. Reviewed

    Yashiro M, Aomatsu N, Takashima T

    Gland surgery   2 ( 1 )   40 - 1   2013.02( ISSN:2227-684X

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    DOI: 10.3978/j.issn.2227-684X.2012.12.01

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  • Locoregional recurrence after neoadjuvant chemotherapy. Reviewed

    Yashiro M, Aomatsu N, Takashima T

    Gland surgery   2 ( 1 )   40 - 1   2013.02( ISSN:2227-684X

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    DOI: 10.3978/j.issn.2227-684X.2012.12.01

    PubMed

  • 癌周囲微小環境のスキルス胃癌細胞増殖能におよぼす影響 Reviewed

    木下 春人, 八代 正和, 渡辺 真央, 大北 仁裕, 森崎 珠実, 福岡 達成, 青松 直撥, 長谷川 毅, 平川 俊基, 吉井 真美, 久保 尚士, 田中 浩明, 六車 一哉, 大平 雅一, 平川 弘聖

    日本胃癌学会総会記事   85回   327 - 327   2013.02

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  • 胃癌幹細胞関連蛋白のプロテオーム解析と臨床的意義の検討 Reviewed

    森崎 珠実, 八代 正和, 木下 春人, 渡邊 真央, 大北 仁裕, 福岡 達成, 長谷川 毅, 櫻井 克宣, 久保 尚士, 田中 浩明, 六車 一哉, 大平 雅一, 梯 アンナ, 鰐渕 英機, 平川 弘聖

    日本胃癌学会総会記事   85回   328 - 328   2013.02

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  • MUC1 and HER2 might be Associated with Invasive Phenotype of Intraductal Papillary Mucinous Neoplasm Reviewed

    Ohira Go, Kimura Kenjiro, Yamada Nobuya, Amano Ryosuke, Nakata Bunzo, Doi Yosuke, Murata Akihiro, Yashiro Masakazu, Tanaka Sayaka, Ohsawa Masahiko, Wakasa Kenichi, Hirakawa Kosei

    HEPATO-GASTROENTEROLOGY   60 ( 125 )   1067 - 1072   2013( ISSN:0172-6390

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    DOI: 10.5754/hge121268

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  • Port Site Metastasis After Laparoscopic-Assisted Distal Gastrectomy (LADG) Reviewed

    Sakurai Katsunobu, Tanaka Hiroaki, Lee Tomohiro, Muguruma Kazuya, Kubo Naoshi, Yashiro Masakazu, Ohira Masaichi, Hirakawa Kosei

    INTERNATIONAL SURGERY   98 ( 4 )   363 - 366   2013( ISSN:0020-8868

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    DOI: 10.9738/INTSURG-D-13-00049.1

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  • Hypoxia Stimulates the EMT of Gastric Cancer Cells through Autocrine TGF beta Signaling Reviewed

    Junko Matsuoka, Masakazu Yashiro, Yosuke Doi, Yuhiko Fuyuhiro, Yukihiro Kato, Osamu Shinto, Satoru Noda, Shinichiro Kashiwagi, Naoki Aomatsu, Toshiki Hirakawa, Tsuyoshi Hasegawa, Kiyoshi Shimizu, Toshiyuki Shimizu, Atsushi Miwa, Nobuya Yamada, Tetsuji Sawada, Kosei Hirakawa

    PLOS ONE   8 ( 5 )   e62310   2013( ISSN:1932-6203

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    Epithelial mesenchymal transition (EMT) is considered to be correlated with malignancy of cancer cells and responsible for cancer invasion and metastasis. We previously reported that distant metastasis was associated with hypoxia in gastric cancer. We therefore investigated the effect of hypoxic condition on EMT of gastric cancer cells. Gastric cancer cells were cultured in normoxia (21% O-2) or hypoxia (1% O-2) for 24 h. EMT was evaluated as the percentage of spindle-shaped cells in total cells. Effect of transforming growth factor beta 1 (TGF beta 1) or tyrosine kinase inhibitors on the EMT was evaluated. The expression level of TGF beta 1 and TGF beta R was evaluated by real time RT-PCR. The TGF beta 1 production from cancer cells was measured by ELISA. Hypoxia stimulated EMT of OCUM-2MD3 and OCUM-12 cells, but not that of OCUM-2M cells. The expression level of TGF beta 1 mRNA under hypoxia was significantly higher than that under normoxia in all of three cell lines. The expression level of TGF beta R mRNA was significantly increased by hypoxia in OCUM-2MD3 cells, but not in OCUM-2M cells. TGF beta R inhibitor, SB431542 or Ki26894, significantly suppressed EMT of OCUM-2MD3 and OCUM-12. TGF beta 1 production from OCUM-2MD3 and OCUM-12 cells was significantly increased under hypoxia in comparison with that under normoxia. These findings might suggest that hypoxia stimulates the EMT of gastric cancer cells via autocrine TGF beta/TGF beta R signaling.

    DOI: 10.1371/journal.pone.0062310

    PubMed

  • Coordinated expression of REG4 and aldehyde dehydrogenase 1 regulating tumourigenic capacity of diffuse-type gastric carcinoma-initiating cells is inhibited by TGF-beta Reviewed

    Katsuno Yoko, Ehata Shogo, Yashiro Masakazu, Yanagihara Kazuyoshi, Hirakawa Kosei, Miyazono Kohei

    JOURNAL OF PATHOLOGY   228 ( 3 )   391 - 404   2012.11( ISSN:0022-3417

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    DOI: 10.1002/path.4020

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  • Coordinated expression of REG4 and aldehyde dehydrogenase 1 regulating tumourigenic capacity of diffuse-type gastric carcinoma-initiating cells is inhibited by TGF-beta Reviewed

    Yoko Katsuno, Shogo Ehata, Masakazu Yashiro, Kazuyoshi Yanagihara, Kosei Hirakawa, Kohei Miyazono

    JOURNAL OF PATHOLOGY   228 ( 3 )   391 - 404   2012.11( ISSN:0022-3417

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    Aldehyde dehydrogenase 1 (ALDH1) has been shown to serve as a marker for cancer-initiating cells (CICs), but little is known about the regulation of the CIC functions of ALDH1+ cancer cells. We isolated ALDH1+ cells from human diffuse-type gastric carcinoma cells and characterized these cells using an Aldefluor assay. ALDH1+ cells constituted 58% of the human diffuse-type gastric carcinoma cells, OCUM-2MLN and HSC-39; were more tumourigenic than ALDH1- cells; and were able to self-renew and generate heterogeneous cell populations. Using gene expression microarray analyses, we identified REG4 (regenerating islet-derived family, member 4) as one of the genes up-regulated in ALDH1+ cells, and thus as a novel marker for ALDH1+ tumour cells. Induced expression of REG4 enhanced the colony-forming ability of OCUM-2MLN cells, while knockdown of REG4 inhibited the tumourigenic potential of ALDH1+ cells. We further found that TGF-beta signalling reduces the expression of ALDH1 and REG4, and the size of the ALDH1+ cell population. In human diffuse-type gastric carcinoma tissues, the expression of ALDH1 and REG4 correlated with each other, as assessed by immunohistochemistry, and ALDH1 expression correlated inversely with Smad3 phosphorylation as a measure of TGF-beta signalling. These findings illustrate that, in diffuse-type gastric carcinoma, REG4 is up-regulated in ALDH1+ CICs, and that the increased tumourigenic ability of ALDH1+ cells depends on REG4. Moreover, TGF-beta down-regulates ALDH1 and REG4 expression, which correlates with a reduction in CIC population size and tumourigenicity. Targeting REG4 in ALDH1+ CICs may provide a novel strategy in the treatment of diffuse-type gastric carcinoma. Copyright (c) 2012 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.

    DOI: 10.1002/path.4020

    PubMed

  • [Mechanisms responsible for the progression of scirrhous gastric cancer]. Reviewed

    Yashiro M, Ohira M, Muguruma K, Shinto O, Hirakawa K

    Nihon rinsho. Japanese journal of clinical medicine   70 ( 10 )   1812 - 6   2012.10( ISSN:0047-1852

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  • PAZOPANIB, A NOVEL MULTI-TARGETED KINASE INHIBITOR, SHOWS POTENT IN VITRO ANTITUMOR ACTIVITY IN GASTRIC CANCER CELL LINES WITH FGFR2 AMPLIFICATION Reviewed

    Park J. O., Jang H. -L., Lee J., Choi Y. -L., Kim K. -M., Cho J., Park S. H., Park Y. S., Lim H. Y., Yashiro M., Kang W. K.

    ANNALS OF ONCOLOGY   23   27 - 27   2012.10( ISSN:0923-7534

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  • [Mechanisms responsible for the progression of scirrhous gastric cancer]. Reviewed

    Yashiro M, Ohira M, Muguruma K, Shinto O, Hirakawa K

    Nihon rinsho. Japanese journal of clinical medicine   70 ( 10 )   1812 - 6   2012.10( ISSN:0047-1852

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  • [Mechanisms responsible for the progression of scirrhous gastric cancer]. Reviewed

    Yashiro M, Ohira M, Muguruma K, Shinto O, Hirakawa K

    Nihon rinsho. Japanese journal of clinical medicine   70 ( 10 )   1812 - 1816   2012.10( ISSN:0047-1852

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    CiNii Article

    Other URL: http://search.jamas.or.jp/link/ui/2012352858

  • プロスタグランジンE2がスキルス胃癌に及ぼす影響およびその阻害剤の有効性 Reviewed

    福岡 達成, 八代 正和, 木下 春人, 森崎 珠実, 大北 仁裕, 青松 直撥, 長谷川 毅, 平川 俊基, 吉井 真実, 櫻井 克宣, 久保 尚士, 田中 浩明, 六車 一哉, 大平 雅一, 平川 弘聖

    日本癌治療学会誌   47 ( 3 )   2162 - 2162   2012.10( ISSN:0021-4671

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  • 胃癌治療におけるプロスタグランジンE2受容体阻害剤の有用性 Reviewed

    福岡 達成, 八代 正和, 大北 仁裕, 森崎 珠実, 青松 直撥, 長谷川 毅, 平川 俊基, 吉井 真実, 松岡 順子, 櫻井 克宣, 永原 央, 木村 健二郎, 天野 良亮, 野田 英児, 久保 尚士, 田中 浩明, 六車 一哉, 大平 雅一, 平川 弘聖

    日本消化器外科学会雑誌   45 ( Suppl.2 )   329 - 329   2012.10( ISSN:0386-9768 ( eISSN:1348-9372

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  • 胃癌幹細胞のプロテオーム解析 Reviewed

    森崎 珠実, 八代 正和, 大北 仁裕, 福岡 達成, 青松 直撥, 長谷川 毅, 平川 俊基, 吉井 真美, 松岡 順子, 櫻井 克宣, 木村 健二郎, 永原 央, 天野 良亮, 野田 英児, 久保 尚士, 田中 浩明, 六車 一哉, 大平 雅一, 平川 弘聖

    日本消化器外科学会雑誌   45 ( Suppl.2 )   328 - 328   2012.10( ISSN:0386-9768 ( eISSN:1348-9372

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  • CD133 Is a Useful Surrogate Marker for Predicting Chemosensitivity to Neoadjuvant Chemotherapy in Breast Cancer Reviewed

    Aomatsu Naoki, Yashiro Masakazu, Kashiwagi Shinichiro, Takashima Tsutomu, Ishikawa Tetsuro, Ohsawa Masahiko, Wakasa Kenichi, Hirakawa Kosei

    PLOS ONE   7 ( 9 )   e45865   2012.09( ISSN:1932-6203

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    DOI: 10.1371/journal.pone.0045865

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  • SIGNIFICANCE OF C-MET AS A THERAPEUTIC TARGET IN TRIPLE-NEGATIVE BREAST CANCER Reviewed

    Kashiwagi S., Yashiro M., Aomatsu N., Kawajiri H., Takashima T., Onoda N., Ishikawa T., Hirakawa K.

    ANNALS OF ONCOLOGY   23   84 - 84   2012.09( ISSN:0923-7534

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  • Foretinib (GSK1363089), a multi-kinase inhibitor of MET and VEGFRs, inhibits growth of gastric cancer cell lines by blocking inter-receptor tyrosine kinase networks Reviewed

    Kataoka Yu, Mukohara Toru, Tomioka Hideo, Funakoshi Yohei, Kiyota Naomi, Fujiwara Yutaka, Yashiro Masakazu, Hirakawa Kosei, Hirai Midori, Minami Hironobu

    INVESTIGATIONAL NEW DRUGS   30 ( 4 )   1352 - 1360   2012.08( ISSN:0167-6997

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    DOI: 10.1007/s10637-011-9699-0

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  • VEGF-A/VEGFR-2 Signaling Plays an Important Role for the Motility of Pancreas Cancer Cells Reviewed

    Doi Yosuke, Yashiro Masakazu, Yamada Nobuya, Amano Ryosuke, Noda Satoru, Hirakawa Kosei

    ANNALS OF SURGICAL ONCOLOGY   19 ( 8 )   2733 - 2743   2012.08( ISSN:1068-9265

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    DOI: 10.1245/s10434-011-2181-6

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  • Successful resection of esophageal carcinoma associated with double aortic arch: a case report. Reviewed

    Kubo N, Ohira M, Yamashita Y, Sakurai K, Tanaka H, Muguruma K, Kimura K, Nagahara H, Noda E, Amano R, Yashiro M, Maeda K, Hirakawa K

    Anticancer research   32 ( 8 )   3351 - 5   2012.08( ISSN:0250-7005

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  • Successful Resection of Esophageal Carcinoma Associated with Double Aortic Arch: A Case Report Reviewed

    Kubo Naoshi, Ohira Masaichi, Yamashita Yoshito, Sakurai Katsunobu, Tanaka Hiroaki, Muguruma Kazuya, Kimura Kenjiro, Nagahara Hisashi, Noda Eiji, Amano Ryosuke, Yashiro Masakazu, Maeda Kiyoshi, Hirakawa Kosei

    ANTICANCER RESEARCH   32 ( 8 )   3351 - 3355   2012.08( ISSN:0250-7005

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  • Foretinib (GSK1363089), a multi-kinase inhibitor of MET and VEGFRs, inhibits growth of gastric cancer cell lines by blocking inter-receptor tyrosine kinase networks Reviewed

    Yu Kataoka, Toru Mukohara, Hideo Tomioka, Yohei Funakoshi, Naomi Kiyota, Yutaka Fujiwara, Masakazu Yashiro, Kosei Hirakawa, Midori Hirai, Hironobu Minami

    INVESTIGATIONAL NEW DRUGS   30 ( 4 )   1352 - 1360   2012.08( ISSN:0167-6997

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    To explore the mechanism of action of foretinib (GSK1363089), an oral multi-kinase inhibitor known to target MET, RON, AXL, and vascular endothelial growth factor receptors (VEGFRs), in gastric cancer, we evaluated the effects of the agent on cell growth and cell signaling in the following panel of gastric cancer cell lines: KATO-III, MKN-1, MKN-7, MKN-45, and MKN-74. Of these, only MKN-45 and KATO-III, which harbor MET and fibroblast growth factor receptor 2 (FGFR2) amplification, respectively, were highly sensitive to foretinib. In MKN-45, 1 mu M of foretinib or PHA665752, another MET kinase inhibitor, inhibited phosphorylation of MET and downstream signaling molecules as expected. In KATO-III, however, PHA665752 inhibited phosphorylation of MET independently of downstream molecules. Further, 1 mu M of foretinib or PD173074, a selective FGFR kinase inhibitor, inhibited phosphorylation of FGFR2 and downstream molecules, suggesting that foretinib targets FGFR2 in KATO-III. We confirmed this novel activity of foretinib against FGFR2 in OCUM-2M, another FGFR2-amplified gastric cancer cell line. Using a phospho-receptor tyrosine kinase array, we found that foretinib inhibits phosphorylation of epidermal growth factor receptor (EGFR), HER3 and FGFR3 via MET inhibition in MKN-45, and EGFR, HER3 and MET via FGFR2 inhibition in KATO-III. Knockdown of HER3 and FGFR3 in MKN-45 with siRNA resulted in the partial inhibition of cell signaling and cell growth. In conclusion, foretinib appears effective against gastric cancer cells harboring not only MET but also FGFR2 amplification, and exerts its inhibitory effects by blocking inter-RTK signaling networks with MET or FGFR2 at their core.

    DOI: 10.1007/s10637-011-9699-0

    PubMed

  • Successful Resection of Esophageal Carcinoma Associated with Double Aortic Arch: A Case Report Reviewed

    Naoshi Kubo, Masaichi Ohira, Yoshito Yamashita, Katsunobu Sakurai, Hiroaki Tanaka, Kazuya Muguruma, Kenjiro Kimura, Hisashi Nagahara, Eiji Noda, Ryosuke Amano, Masakazu Yashiro, Kiyoshi Maeda, Kosei Hirakawa

    ANTICANCER RESEARCH   32 ( 8 )   3351 - 3355   2012.08( ISSN:0250-7005

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    Double aortic arch (DAA) is an extremely rare vascular malformation which causes tracheal and esophageal compression, resulting in respiratory symptoms such as stridor and wheezing, or feeding problems such as dysphagia, usually during the first few months of life. In contrast, this disorder is rarely diagnosed in adults. We herein present an elderly case with thoracic esophageal carcinoma with DAA. TO the best of our knowledge, this is only the second report of a successfully resected case of esophageal cancer associated with DAA in the English literature. Moreover, this is the first reported case of symptomatic DAA with esophageal carcinoma. Spiral computed tomography and three-dimensional reconstruction was very useful for preoperative assessment of the abnormal vessels.

    PubMed

  • VEGF-A/VEGFR-2 Signaling Plays an Important Role for the Motility of Pancreas Cancer Cells Reviewed

    Yosuke Doi, Masakazu Yashiro, Nobuya Yamada, Ryosuke Amano, Satoru Noda, Kosei Hirakawa

    ANNALS OF SURGICAL ONCOLOGY   19 ( 8 )   2733 - 43   2012.08( ISSN:1068-9265

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    Pancreatic cancer is one of the most lethal solid tumors. Vascular endothelial growth factor receptors (VEGFRs) are expressed not only by endothelial cells but also by pancreatic cancer cells. VEGFRs might play an important role for the development of pancreatic cancer cells. The purpose of this study was to evaluate the efficacy of VEGF/VEGFR-2-targeted therapy in pancreatic carcinoma.
    Five pancreatic carcinoma cell lines were used. The expression level of VEGFR-2 of cancer cells was examined by RT-PCR and Western blot. The effects of VEGFs, bevacizumab as an anti-VEGF antibody, sunitinib as a tyrosine kinase inhibitor against VEGFRs, and VEGF-R2 siRNA on the motility activity of pancreatic cancer cells were examined by invasion assay and wound healing assay. The effect of VEGF, bevacizumab, and sunitinib on the phosphorylation of VEGFR-2 and downstream effecter molecules, MAPK and PI3K, was examined by western blot.
    Pancreatic cancer cell lines expressed VEGFR-2. VEGF-A significantly increased the motility of pancreas cancer cells, which was inhibited by VEGFR-2 siRNA. Conditioned medium from pancreas cancer cells significantly stimulated the motility of pancreas cancer cells. VEGF/VEGFR inhibitors, bevacizumab and sunitinib, significantly decreased the motility of pancreas cancer cells. VEGFR-2 phosphorylation level of pancreas cancer cells was increased by VEGF-A. Bevacizumab and sunitinib decreased the level of VEGFR-2 phosphorylation, p-ERK, and p-Akt expression. VEGF-A decreased zonula occludens (ZO-1) or ZO-2 expression in pancreas cancer cells.
    VEGF-A/VEGFR-2 signaling plays an important role in inducing invasion and migration of pancreatic cancer cells.

    DOI: 10.1245/s10434-011-2181-6

    PubMed

  • Successful resection of esophageal carcinoma associated with double aortic arch: a case report. Reviewed

    Kubo N, Ohira M, Yamashita Y, Sakurai K, Tanaka H, Muguruma K, Kimura K, Nagahara H, Noda E, Amano R, Yashiro M, Maeda K, Hirakawa K

    Anticancer research   32 ( 8 )   3351 - 5   2012.08( ISSN:0250-7005

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  • Concurrent biological targeting therapy of squamous cell carcinoma of the esophagus with cetuximab and trastuzumab Reviewed

    Yamazaki Masanao, Yamashita Yoshito, Kubo Naoshi, Yashiro Masakazu, Ohira Masaichi, Ako Eiji, Tanaka Hiroaki, Muguruma Kazuya, Sawada Tetsuji, Hirakawa Kosei

    ONCOLOGY REPORTS   28 ( 1 )   49 - 54   2012.07( ISSN:1021-335X

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    DOI: 10.3892/or.2012.1803

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  • Concurrent biological targeting therapy of squamous cell carcinoma of the esophagus with cetuximab and trastuzumab Reviewed

    Masanao Yamazaki, Yoshito Yamashita, Naoshi Kubo, Masakazu Yashiro, Masaichi Ohira, Eiji Ako, Hiroaki Tanaka, Kazuya Muguruma, Tetsuji Sawada, Kosei Hirakawa

    ONCOLOGY REPORTS   28 ( 1 )   49 - 54   2012.07( ISSN:1021-335X

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    The ERBB proteins are cell membrane tyrosine kinase receptors. Among these receptors, ERBB1 (EGER or HER1) and ERBB2 (HER2/Neu) have been reported to be the most important in terms of the development and progression of squamous cell carcinoma of the esophagus (SCC). Thus, targeting of ERBB1 and ERBB2 may become a promising strategy to treat SCC. In the present study, we examined ER BB1 and ERBB2 expression of SCC cell lines (TT, TE2, TE6 and TE10) and tumor samples. In addition, we evaluated the effect of the anti-ERBB1 antibody cetuximab and the anti-ERBB2 antibody trastuzumab for SCC in vitro and in vivo. Biological activities (receptor down regulation, the phosphorylation of MAPK and AKT) induced by the two agents were also investigated. Immunohistochemistry of SCC samples showed that ERBB1 was detected in 84%, while ERBB2 was detected in 30%. RT-PCR analysis revealed that ERBB1 and ERBB2 mRNA were detectable in all four cell lines. MTT cell proliferation analysis showed that cetuximab, but not trastuzumab, inhibited growth in each of the SCC cell lines in a dose-dependent manner. Further, cetuximab and trastuzumab used together produced stronger inhibition of growth compared to cetuximab alone. Cetuximab downregulated ERBB1, but not ERBB2, at the TE6 cell surface. However, neither ERBB1 nor ERBB2 showed any downregulation by trastuzumab at the TE6 cell surface. Cetuximab, not but trastuzumab, inhibited the phosphorylation of MAPK and Akt. When administered in combination, the two agents inhibited Akt phosphorylation to a greater degree compared to treatment with cetuximab alone. In the in vivo study, cetuximab, but not trastuzumab, significantly inhibited the TT tumors. Additionally, the combination of cetuximab with trastuzumab induced a synergistic inhibitory antitumor effect in the TT tumors. In conclusion, combination of cetuximab and trastuzumab revealed a synergistic antitumor effect for SCC in vitro and in vivo. The antitumor effect may be induced by the inhibition of the phosphorylation of Akt. These findings suggest that combination therapy including cetuximab and trastuzumab may be a promising strategy to treat SCC.

    DOI: 10.3892/or.2012.1803

    PubMed

  • 胃癌転移リンパ節における免疫細胞プロファイルの検討 Reviewed

    大北 仁裕, 田中 浩明, 吉井 真美, 六車 一哉, 久保 尚士, 八代 正和, 前田 清, 澤田 鉄二, 大平 雅一, 平川 弘聖

    日本消化器外科学会総会   67回   2 - 2   2012.07

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  • Correlation between efficacy of PSK postoperative adjuvant immunochemotherapy for gastric cancer and expression of MHC class I Reviewed

    Ito Gentaro, Tanaka Hiroaki, Ohira Masaichi, Yoshii Mami, Muguruma Kazuya, Kubo Naoshi, Yashiro Masakazu, Yamada Nobuya, Maeda Kiyoshi, Sawada Tetsuji, Hirakawa Kosei

    EXPERIMENTAL AND THERAPEUTIC MEDICINE   3 ( 6 )   925 - 930   2012.06( ISSN:1792-0981

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    DOI: 10.3892/etm.2012.537

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  • Correlation between efficacy of PSK postoperative adjuvant immunochemotherapy for gastric cancer and expression of MHC class I Reviewed

    Gentaro Ito, Hiroaki Tanaka, Masaichi Ohira, Mami Yoshii, Kazuya Muguruma, Naoshi Kubo, Masakazu Yashiro, Nobuya Yamada, Kiyoshi Maeda, Tetsuji Sawada, Kosei Hirakawa

    EXPERIMENTAL AND THERAPEUTIC MEDICINE   3 ( 6 )   925 - 930   2012.06( ISSN:1792-0981

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    Protein-bound polysaccharide K (PSK) is a glycoprotein that is purified from the mushroom Coriolus versicolor. In Japan, PSK is clinically used in combination with anticancer agents following gastric cancer surgery. Evaluation of the response is difficult, as efficacy is determined via antitumor immunoenhancing effects, and for that reason PSK has not become a standard therapy. The present study evaluated the expression of MHC class I in gastric cancer patients who received PSK postoperative adjuvant immunochemotherapy, and investigated the correlation between MHC class I expression and clinical outcomes. The subjects comprised 349 patients with stage II/III gastric cancer, who had received adjuvant therapy following curative resection between 1995 and 2008. MHC class I expression in the primary lesion was evaluated by immunohistochemical staining. Patients were divided into two treatment groups: one was only administered oral chemotherapy (chemotherapy-only group) and the other was administered chemotherapy plus PSK (PSK group). The clinical outcomes were compared between the two groups. The two groups did not differ in regard to their MHC class I expression. Expression-negative cases demonstrated 3-year recurrence-free survival (RFS) rates of 65% in the PSK group and 47% in the chemotherapy-only group. Therefore, the PSK group revealed a prolonged survival. For the 82 expression-negative cases with pN2 or greater, the RFS rates were 68% in the PSK group and 28% in the chemotherapy-only group, representing a significant difference. Thus, PSK adjuvant immunochemotherapy may be effective in MHC class I-negative patients, who are in a state of antitumor immunological tolerance, and patients with advanced lymph node metastasis of pN2 or greater.

    DOI: 10.3892/etm.2012.537

    PubMed

  • Expression of Forkhead box P3 in tumour cells causes immunoregulatory function of signet ring cell carcinoma of the stomach Reviewed

    Yoshii M., Tanaka H., Ohira M., Muguruma K., Iwauchi T., Lee T., Sakurai K., Kubo N., Yashiro M., Sawada T., Hirakawa K.

    BRITISH JOURNAL OF CANCER   106 ( 10 )   1668 - 1674   2012.05( ISSN:0007-0920

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    DOI: 10.1038/bjc.2012.141

  • Expression of Forkhead box P3 in tumour cells causes immunoregulatory function of signet ring cell carcinoma of the stomach. Reviewed

    Yoshii M, Tanaka H, Ohira M, Muguruma K, Iwauchi T, Lee T, Sakurai K, Kubo N, Yashiro M, Sawada T, Hirakawa K

    British journal of cancer   106 ( 10 )   1668 - 74   2012.05( ISSN:0007-0920

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    DOI: 10.1038/bjc.2012.141

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  • Role of the Stemness Factors Sox2, Oct3/4, and Nanog in Gastric Carcinoma Reviewed

    Junko Matsuoka, Masakazu Yashiro, Katsunobu Sakurai, Naoshi Kubo, Hiroaki Tanaka, Kazuya Muguruma, Tetsuji Sawada, Masaichi Ohira, Kosei Hirakawa

    JOURNAL OF SURGICAL RESEARCH   174 ( 1 )   130 - 5   2012.05( ISSN:0022-4804

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    Background. Cancer stem cells have been proposed to be responsible for cancer tumorigenicity, and then to persist in tumors as a distinct population and cause relapse and metastasis. Recently, the stemness factors Sox2, Oct3/4, and Nanog were associated with induced pluripotent stem cells, suggesting a correlation between these stemness factors and cancer stem cells. We therefore investigated the role of stemness factors in the tumorigenesis of human gastric cancer.
    Materials and Methods. A total of 290 patients who had undergone resection of a primary gastric cancer at our institute were enrolled. A curative R0 resection was performed for 253 of 290 patients, and the remaining 37 patients were treated with a palliative resection. The expression levels of Sox2, Oct3/4, and Nanog were analyzed by immunohistochemistry.
    Results. Sox2, Oct3/4, and Nanog expression were positive in 159 (55%), 129 (44%), and 28 (10%) of 290 gastric cancers, respectively. There was a statistically significant correlation between Sox2-positive or Oct3/4-negative expression and invasion depth, lymph node metastasis, or lymphatic invasion. In 253 patients with a curative resection, the prognosis of patients with Sox2-positivetumors orOct3/4-negativetumorswas significantly (P &lt; 0.01 or P = 0.04, log-rank) worse than that of patients with Sox2-negative or Oct3/4-positive tumors, respectively. A multivariate analysis revealed the expression of Sox2 or Oct3/4 to be an independent prognostic factor (P = 0.01 or P = 0.04).
    Conclusions. Sox2-positive expression or Oct3/4-negative expression might be associated with invasion of gastric cancer. Sox2 and Oct3/4 might be independent prognostic factors for patients with gastric cancer. (C) 2012 Elsevier Inc. All rights reserved.

    DOI: 10.1016/j.jss.2010.11.903

    PubMed

  • Role of the Stemness Factors Sox2, Oct3/4, and Nanog in Gastric Carcinoma Reviewed

    Matsuoka Junko, Yashiro Masakazu, Sakurai Katsunobu, Kubo Naoshi, Tanaka Hiroaki, Muguruma Kazuya, Sawada Tetsuji, Ohira Masaichi, Hirakawa Kosei

    JOURNAL OF SURGICAL RESEARCH   174 ( 1 )   130 - 135   2012.05( ISSN:0022-4804

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    DOI: 10.1016/j.jss.2010.11.903

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  • 腹膜播種の治療戦略 リンパ節転移率に基づいた胃癌腹膜播種に対する治療戦略 Reviewed

    田中 浩明, 六車 一哉, 久保 尚士, 櫻井 克宣, 永原 央, 木村 健二郎, 天野 良亮, 野田 英児, 山田 靖哉, 八代 正和, 山下 好人, 前田 清, 澤田 鉄二, 大平 雅一, 平川 弘聖

    日本外科系連合学会誌   37 ( 3 )   444 - 444   2012.05( ISSN:0385-7883 ( eISSN:1882-9112

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  • 腹腔鏡下幽門側胃切除術(LADG)施行時に使用するデバイスの変遷について Reviewed

    六車 一哉, 田中 浩明, 櫻井 克宣, 木村 健二郎, 永原 央, 天野 良亮, 野田 英児, 久保 尚士, 八代 正和, 山田 靖哉, 山下 好人, 前田 清, 澤田 鉄二, 大平 雅一, 平川 弘聖

    日本外科系連合学会誌   37 ( 3 )   639 - 639   2012.05( ISSN:0385-7883 ( eISSN:1882-9112

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  • Polymeric micelles incorporating (1,2-diaminocyclohexane)platinum (II) suppress the growth of orthotopic scirrhous gastric tumors and their lymph node metastasis Reviewed

    Rafi Md, Cabral H., Kano M. R., Mi P., Iwata C., Yashiro M., Hirakawa K., Miyazono K., Nishiyama N., Kataoka K.

    JOURNAL OF CONTROLLED RELEASE   159 ( 2 )   189 - 196   2012.04( ISSN:0168-3659

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    DOI: 10.1016/j.jconrel.2012.01.038

  • PI3K/Akt signalling is required for the attachment and spreading, and growth in vivo of metastatic scirrhous gastric carcinoma Reviewed

    Matsuoka T., Yashiro M., Nishioka N., Hirakawa K., Olden K., Roberts J. D.

    BRITISH JOURNAL OF CANCER   106 ( 9 )   1535 - 1542   2012.04( ISSN:0007-0920

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    DOI: 10.1038/bjc.2012.107

  • An EGFR inhibitor enhances the efficacy of SN38, an active metabolite of irinotecan, in SN38-refractory gastric carcinoma cells Reviewed

    Yashiro Masakazu, Qiu Hong, Hasegawa Tsuyoshi, Zhang Xiaotian, Morisaki Tamami, Fukuoka Tatsuynari, Aomatsu Naoki, Hirakawa Toshiki, Sakurai Katsunobu, Kubo Naoshi, Tanaka Hiroaki, Yamada Nobuya, Maeda Kiyoshi, Sawada Tetsuji, Ohira Masaichi, Hirakawa Kosei

    CANCER RESEARCH   72   2012.04( ISSN:0008-5472

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    DOI: 10.1158/1538-7445.AM2012-780

  • Antitumor effect of prostaglandin E2 receptor inhibitors in gastric carcinoma Reviewed

    Fukuoka Tatsunari, Yashiro Masakazu, Takeda Hiroshi, Maruyama Takayuki, Morisaki Tamami, Hasegawa Tsuyoshi, Hirakawa Toshiki, Aomatshu Naoki, Matsuoka Junko, Sakurai Katsunobu, Kimura Kenjiro, Nagahara Hisashi, Amano Ryosuke, Noda Eiji, Kubo Naoshi, Tanaka Hiroaki, Muguruma Kazuya, Yamada Nobuya, Maeda Kiyoshi, Ohira Masaichi, Ishikawa Tetsuro, Hirakawa Kosei

    CANCER RESEARCH   72   2012.04( ISSN:0008-5472

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    DOI: 10.1158/1538-7445.AM2012-1211

  • Cancer-associated fibroblasts mediate extracellular matrix remodeling and three-dimensional invasion of scirrhous gastric carcinoma cells Reviewed

    Yamaguchi Hideki, Yanagihara Kazuyoshi, Yashiro Masakazu, Sakai Ryuichi

    CANCER RESEARCH   72   2012.04( ISSN:0008-5472

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    DOI: 10.1158/1538-7445.AM2012-47

  • The expression of human equilibrative nucleoside transporter 1 (hENT1) is associated with overall survival in advanced biliary tract carcinoma (BTC) treated with gemcitabine Reviewed

    Murata Akihiro, Amano Ryousuke, Kimura Kenjiro, Yamada Nobuya, Nakata Bunzo, Nagahara Hisashi, Noda Eiji, Kubo Naoshi, Tanaka Hiroaki, Muguruma Kazuya, Yashiro Masakazu, Maeda Kiyoshi, Ohira Masaichi, Ishikawa Tetsurou, Hirakawa Kosei

    CANCER RESEARCH   72   2012.04( ISSN:0008-5472

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    DOI: 10.1158/1538-7445.AM2012-711

  • The epithelial-mesenchymal transition of gastric cancer cells was stimulated by TGF beta R signaling in hypoxia Reviewed

    Matsuoka Junko, Yashiro Masakazu, Aomatsu Naoki, Hirakawa Toshiki, Hasegawa Tsuyoshi, Fukuoka Tatsunari, Morisaki Tamami, Kubo Naoshi, Tanaka Hiroaki, Muguruma Kazuya, Yamada Nobuya, Ohira Masaichi, Ishikawa Tetsuro, Hirakawa Kosei

    CANCER RESEARCH   72   2012.04( ISSN:0008-5472

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    DOI: 10.1158/1538-7445.AM2012-2411

  • TGF-beta from niche fibroblasts increases the stemness cancer stem cell-like side population cells in gastric cancer Reviewed

    Hasegawa Tsuyoshi, Yashiro Masakazu, Morisaki Tamami, Aomatsu Naoki, Hirakawa Toshiki, Fukuoka Tatsunari, Matsuoka Junko, Sakurai Katsunobu, Kimura Kenjiro, Nagahara Hisashi, Amano Ryosuke, Noda Eiji, Kubo Naoshi, Tanaka Hiroaki, Muguruma Kazuya, Yamada Nobuya, Maeda Kiyoshi, Ohira Masaichi, Ishikawa Tetsuro, Hirakawa Kosei

    CANCER RESEARCH   72   2012.04( ISSN:0008-5472

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    DOI: 10.1158/1538-7445.AM2012-3337

  • Relationship between loss of heterozygosity of HLA-A gene and HLA class I expression in gastric cancer Reviewed

    Yoshii Mami, Tanaka Hiroaki, Sakurai Katsunobu, Nagahara Hisashi, Kimura Kenjiro, Amano Ryosuke, Noda Eiji, Kubo Naoshi, Muguruma Kazuya, Yamada Nobuya, Yashiro Masakazu, Maeda Kiyoshi, Sawada Tetsuji, Ohira Masaichi, Ishikawa Tetsuro, Hirakawa Kosei

    CANCER RESEARCH   72   2012.04( ISSN:0008-5472

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    DOI: 10.1158/1538-7445.AM2012-514

  • Predictive value of metastatic lymph node ratio in diagnosis of recurrence after surgical resection of gastric cancer Reviewed

    Tanaka Hiroaki, Muguruma Kazuya, Yoshii Mami, Lee Tomohiro, Kimura Kenjiro, Nagahara Hisashi, Noda Eiji, Amano Ryosuke, Kubo Naoshi, Yashiro Masakazu, Yamada Nobuya, Maeda Kiyoshi, Sawada Tetsuji, Ohira Masaichi, Hirakawa Kosei

    CANCER RESEARCH   72   2012.04( ISSN:0008-5472

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    DOI: 10.1158/1538-7445.AM2012-3396

  • Effect of neoadjuvant therapy for the number of lymph node micrometastasis in esophageal squamous cell carcinoma Reviewed

    Lee Tomohiro, Tanaka Hiroaki, Yoshii Mami, Sakurai Katsunobu, Nagahara Hisashi, Kimura Kenjirou, Amano Ryousuke, Noda Eiji, Kubo Naoshi, Muguruma Kazuya, Yamada Nobuya, Yashiro Masakazu, Maeda Kiyoshi, Onoda Naoyoshi, Sawada Tetsuji, Nakata Bunzo, Ohira Masaichi, Ishikawa Tetsurou, Hirakawa Kosei

    CANCER RESEARCH   72   2012.04( ISSN:0008-5472

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    DOI: 10.1158/1538-7445.AM2012-3440

  • Comparison proteome analysis of scirrhous gastric carcinoma stem cell-like SP and hypoxia-resistant cell lines Reviewed

    Morisaki Tamami, Yashiro Masakazu, Kakehashi Anna, Okita Yoshihiro, Fukuoka Tatsunari, Aomatsu Naoki, Yoshii Mami, Hasegawa Tsuyoshi, Matsuoka Junko, Nagahara Hisashi, Kimura Kenjiro, Noda Eiji, Amano Ryosuke, Kubo Naoshi, Tanaka Hiroaki, Muguruma Kazuya, Yamada Nobuya, Maeda Kiyoshi, Nakata Bunzo, Ohira Masaichi, Wanibuchi Hideki, Hirakawa Kosei

    CANCER RESEARCH   72   2012.04( ISSN:0008-5472

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    DOI: 10.1158/1538-7445.AM2012-3380

  • Clinical significance of insulin-like growth factor 1 receptor (IGF1R) expression in pancreatic cancer Reviewed

    Hirakawa Toshiki, Yashiro Masakazu, Morisaki Tamami, Aomatsu Naoki, Fukuoka Tatsunari, Yoshii Mami, Hasegawa Tsuyoshi, Matsuoka Junko, Nagahara Hisashi, Kimura Kenjiro, Noda Eiji, Amano Ryosuke, Kubo Naoshi, Tanaka Hiroaki, Muguruma Kazuya, Yamada Nobuya, Maeda Kiyoshi, Nakata Bunzo, Ohira Masaichi, Hirakawa Kosei

    CANCER RESEARCH   72   2012.04( ISSN:0008-5472

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    DOI: 10.1158/1538-7445.AM2012-708

  • CD133 is a useful surrogate marker to predict chemosensitivity of neoadjuvant chemotherapy for breast cancer Reviewed

    Aomatsu Naoki, Yashiro Masakazu, Kashiwagi Shinichiro, Morisaki Tamami, Fukuoka Tatsunari, Hirakawa Tosiki, Hasegawa Tsuyoshi, Matsuoka Junko, Takashima Tsutomu, Kawajiri Hidemi, Onoda Naoyoshi, Ishikawal Tetsuro, Hirakawa Kosei

    CANCER RESEARCH   72   2012.04( ISSN:0008-5472

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    DOI: 10.1158/1538-7445.AM2012-707

  • CD133 is a useful surrogate marker to predict chemosensitivity of neoadjuvant chemotherapy for breast cancer Reviewed

    Aomatsu Naoki, Yashiro Masakazu, Kashiwagi Shinichiro, Morisaki Tamami, Fukuoka Tatsunari, Hirakawa Tosiki, Hasegawa Tsuyoshi, Matsuoka Junko, Takashima Tsutomu, Kawajiri Hidemi, Onoda Naoyoshi, Ishikawal Tetsuro, Hirakawa Kosei

    CANCER RESEARCH   72   2012.04( ISSN:0008-5472

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    DOI: 10.1158/1538-7445.AM2012-707

  • Effect of neoadjuvant therapy for the number of lymph node micrometastasis in esophageal squamous cell carcinoma Reviewed

    Lee Tomohiro, Tanaka Hiroaki, Yoshii Mami, Sakurai Katsunobu, Nagahara Hisashi, Kimura Kenjirou, Amano Ryousuke, Noda Eiji, Kubo Naoshi, Muguruma Kazuya, Yamada Nobuya, Yashiro Masakazu, Maeda Kiyoshi, Onoda Naoyoshi, Sawada Tetsuji, Nakata Bunzo, Ohira Masaichi, Ishikawa Tetsurou, Hirakawa Kosei

    CANCER RESEARCH   72   2012.04( ISSN:0008-5472

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    DOI: 10.1158/1538-7445.AM2012-3440

  • Cancer-associated orthotopic myofibroblasts stimulates the motility of gastric carcinoma cells Reviewed

    Fuyuhiro Yuhiko, Yashiro Masakazu, Noda Satoru, Matsuoka Junko, Hasegawa Tsuyoshi, Kato Yukihiro, Sawada Tetsuji, Hirakawa Kosei

    CANCER SCIENCE   103 ( 4 )   797 - 805   2012.04( ISSN:1347-9032

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    DOI: 10.1111/j.1349-7006.2012.02209.x

    PubMed

  • 癌に関連した同所性筋線維芽細胞は胃癌細胞の運動性を刺激する(Cancer-associated orthotopic myofibroblasts stimulates the motility of gastric carcinoma cells) Reviewed

    Fuyuhiro Yuhiko, Yashiro Masakazu, Noda Satoru, Matsuoka Junko, Hasegawa Tsuyoshi, Kato Yukihiro, Sawada Tetsuji, Hirakawa Kosei

    John Wiley & Sons Australia, Ltd Cancer Science   103 ( 4 )   797 - 805   2012.04( ISSN:1347-9032

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    癌に関連した同所性線維芽細胞(CaF)-29とCaF-33を腫瘍胃壁から、正常な同所性線維芽細胞(NF)-29とNF-33を非腫瘍胃壁から樹立した。α-平滑筋アクチン陽性線維芽細胞を筋線維芽細胞と定義したところ、筋線維芽細胞の比率はCaF-29が33%、CaF-33が46%で、NF-29の11%、NF-33の13%に比べて高かった。同所性線維芽細胞株は四つとも胃癌細胞の運動性(遊走能と浸潤能を含む)を増加させたが、その運動刺激活性はCaF-29とCaF-33の方がNF-29とNF-33に比べて有意に大きかった。CaFの運動刺激活性はSmad2 siRNA処理および抗形質転換増殖因子-β中和抗体によりダウンレギュレートされた。以上より、癌に関連した同所性筋線維芽細胞は胃癌の進行に重要な役割を果たしている可能性があることが示唆された。筋線維芽細胞により産生される形質転換増殖因子-βは胃癌細胞株の侵攻性に関連する因子の一つであると考えられた。

  • Cancer-associated orthotopic myofibroblasts stimulates the motility of gastric carcinoma cells Reviewed

    Yuhiko Fuyuhiro, Masakazu Yashiro, Satoru Noda, Junko Matsuoka, Tsuyoshi Hasegawa, Yukihiro Kato, Tetsuji Sawada, Kosei Hirakawa

    CANCER SCIENCE   103 ( 4 )   797 - 805   2012.04( ISSN:1347-9032

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    Tumor progression has been recognized as the product of evolving crosstalk between cancer cells and the surrounding stromal cells. Cancer-associated orthotopic myofibroblasts may be linked to the progression of gastric carcinomas. To understand the significance of orthotopic myofibroblasts, we examined the effects of cancer-associated orthotopic myofibroblasts on the malignant phenotype of gastric cancer cells. Three human gastric cancer cell lines (OCUM-2MD3, OCUM-12, MKN-45) and four human gastric fibroblast cell lines (cancer-associated orthotopic fibroblast [CaF]-29, CaF-33, normal orthotopic fibroblast [NF]-29, NF-33) were used. The cancer-associated orthotopic fibroblast cell lines CaF-29 and CaF-33 were established from a tumoral gastric wall, and normal orthotopic fibroblast NF-29 and NF-33 were established from a non-tumoral gastric wall. Fibroblasts that were a-smooth muscle actin-positive were defined as myofibroblasts. We examined the effects of cancer-associated orthotopic myofibroblasts on the aggressiveness of gastric cancer cells by wound-healing assay, invasion assay, and RT-PCR. The ratios of myofibroblasts in CaF-29 (33%) and CaF-33 (46%) were significantly (P similar to&lt;similar to 0.001) greater than those in NF-29 (11%) or NF-33 (13%). Although all four orthotopic fibroblast lines increased the motility of gastric cancer cells, including migration and invasion ability, the motility-stimulating activity of cancer-associated fibroblasts (CaF-29 and CaF-33) was significantly higher than that of normal fibroblasts (NF-29 and NF-33). These motility-stimulating activities of cancer-associated orthotopic fibroblasts were downregulated by Smad2 siRNA treatment and anti-transforming growth factor-beta neutralizing antibody. These findings suggest that cancer-associated orthotopic myofibroblasts may play an important role in the progression of gastric cancers and that transforming growth factor-beta produced by myofibroblasts may be one of the factors associated with the aggressiveness of gastric carcinoma cells. (Cancer Sci 2012; 103: 797805)

    DOI: 10.1111/j.1349-7006.2012.02209.x

    PubMed

  • 癌に関連した同所性筋線維芽細胞は胃癌細胞の運動性を刺激する(Cancer-associated orthotopic myofibroblasts stimulates the motility of gastric carcinoma cells) Reviewed

    Fuyuhiro Yuhiko, Yashiro Masakazu, Noda Satoru, Matsuoka Junko, Hasegawa Tsuyoshi, Kato Yukihiro, Sawada Tetsuji, Hirakawa Kosei

    Cancer Science   103 ( 4 )   797 - 805   2012.04( ISSN:1347-9032

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    Publishing type:Research paper (scientific journal)  

    癌に関連した同所性線維芽細胞(CaF)-29とCaF-33を腫瘍胃壁から、正常な同所性線維芽細胞(NF)-29とNF-33を非腫瘍胃壁から樹立した。α-平滑筋アクチン陽性線維芽細胞を筋線維芽細胞と定義したところ、筋線維芽細胞の比率はCaF-29が33%、CaF-33が46%で、NF-29の11%、NF-33の13%に比べて高かった。同所性線維芽細胞株は四つとも胃癌細胞の運動性(遊走能と浸潤能を含む)を増加させたが、その運動刺激活性はCaF-29とCaF-33の方がNF-29とNF-33に比べて有意に大きかった。CaFの運動刺激活性はSmad2 siRNA処理および抗形質転換増殖因子-β中和抗体によりダウンレギュレートされた。以上より、癌に関連した同所性筋線維芽細胞は胃癌の進行に重要な役割を果たしている可能性があることが示唆された。筋線維芽細胞により産生される形質転換増殖因子-βは胃癌細胞株の侵攻性に関連する因子の一つであると考えられた。

  • PI3K/Akt signalling is required for the attachment and spreading, and growth in vivo of metastatic scirrhous gastric carcinoma Reviewed

    T. Matsuoka, M. Yashiro, N. Nishioka, K. Hirakawa, K. Olden, J. D. Roberts

    BRITISH JOURNAL OF CANCER   106 ( 9 )   1535 - 1542   2012.04( ISSN:0007-0920

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    BACKGROUND: PI3K/Akt (PKB) pathway has been shown in several cell types to be activated by ligands to cell surface integrins, leading to the metastasis of tumour cells. The signalling pathways involved in the metastatic spread of human scirrhous gastric carcinoma cells have not been defined.
    METHODS: The role of the PI3K/Akt pathway in an extensive peritoneal-seeding cell line, OCUM-2MD3 and a parental cell line, OCUM-2M, was investigated by assessing in vitro adhesion and spreading assay, and in vivo peritoneal metastatic model. We also examined the correlation of PI3K/Akt pathway with integrin signals by immunoprecipitations, using cells by transfection with mutant p85 (Delta p85).
    RESULTS: Adhesiveness and spreading of OCUM-2MD3 cells on collagen type IV was significantly decreased by PI3K inhibitors and expression of mutant p85, but not by inhibitors of protein kinase C (PKC) or extracellular signal-regulated kinase (ERK). Immunoprecipitation studies indicated that the PI3K/Akt pathway was associated with integrin signalling through Src and vinculin. In an in vivo experimental metastasis model, p85 inhibition reduced peritoneal metastasis of OCUM-2MD3 cells.
    CONCLUSION: PI3K/Akt signalling may be required for integrin-dependent attachment and spreading of scirrhous gastric carcinoma cells, and would be translated into generating better strategies to optimise their use in cancer clinical trials. British Journal of Cancer (2012) 106, 1535-1542. doi:10.1038/bjc.2012.107 www.bjcancer.com (C) 2012 Cancer Research UK

    DOI: 10.1038/bjc.2012.107

  • PS-005-5 低酸素環境下における胃癌細胞の上皮間葉転換(EMT)の機序と阻害剤の検討(PS-005 胃 基礎-1,ポスターセッション,第112回日本外科学会定期学術集会) Reviewed

    松岡 順子, 八代 正和, 青松 直撥, 平川 俊基, 長谷川 毅, 久保 尚士, 田中 浩明, 六車 一哉, 山田 靖哉, 大平 雅一, 石川 哲郎, 平川 弘聖

    一般社団法人日本外科学会 日本外科学会雑誌   113 ( 2 )   2012.03( ISSN:03014894

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    CiNii Article

  • VD-009-5 腹腔鏡下大腸癌手術における縫合不全ゼロを目指したDST吻合法の工夫(VD-009 ビデオセッション(9)直腸 鏡視下-1,第112回日本外科学会定期学術集会) Reviewed

    永原 央, 前田 清, 野田 英児, 渋谷 雅常, 木村 健二郎, 天野 良亮, 久保 尚士, 田中 浩明, 六車 一哉, 山田 靖哉, 八代 正和, 仲田 文造, 大平 雅一, 石川 哲郎, 平川 弘聖

    一般社団法人日本外科学会 日本外科学会雑誌   113 ( 2 )   2012.03( ISSN:03014894

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  • PS-148-7 膵癌におけるIGF1R発現と予後の相関関係(PS-148 膵 基礎-2,ポスターセッション,第112回日本外科学会定期学術集会) Reviewed

    平川 俊基, 八代 正和, 森崎 珠実, 福岡 達成, 吉井 真美, 長谷川 毅, 青松 直撥, 松岡 順子, 村田 哲洋, 木村 健二郎, 永原 央, 天野 良亮, 野田 英児, 久保尚士, 久保 尚士, 田中 浩明, 六車 一哉, 山田 靖哉, 前田 清, 仲田 文造, 大平 雅一, 平川 弘聖

    一般社団法人日本外科学会 日本外科学会雑誌   113 ( 2 )   2012.03( ISSN:03014894

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  • PS-129-5 胃癌リンパ節転移は,HLA class I発現低下と相関する(PS-129 胃 基礎-5,ポスターセッション,第112回日本外科学会定期学術集会) Reviewed

    吉井 真美, 田中 浩明, 木村 健二郎, 永原 央, 天野 良亮, 野田 英児, 久保 尚士, 六車 一哉, 山田 靖哉, 八代 正和, 前田 清, 澤田 鉄二, 大平 雅一, 石川 哲郎, 平川 弘聖

    一般社団法人日本外科学会 日本外科学会雑誌   113 ( 2 )   2012.03( ISSN:03014894

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  • PS-128-1 長期成績からみた胃癌幽門側切除後消化管再建法についての検討(PS-128 胃 手術手技,ポスターセッション,第112回日本外科学会定期学術集会) Reviewed

    六車 一哉, 田中 浩明, 櫻井 克宣, 久保 尚士, 木村 健二郎, 永原 央, 天野 良亮, 野田 英児, 八代 正和, 山田 靖哉, 山下 好人, 前田 清, 澤田 鉄二, 大平 雅一, 平川 弘聖

    一般社団法人日本外科学会 日本外科学会雑誌   113 ( 2 )   2012.03( ISSN:03014894

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  • PS-124-8 原発性十二指腸癌切除例の検討(PS-124 胃 臨床,ポスターセッション,第112回日本外科学会定期学術集会) Reviewed

    平田 啓一郎, 天野 良亮, 山田 靖哉, 木村 健二郎, 村田 哲洋, 櫻井 克宣, 川尻 成美, 永原 央, 野田 英児, 久保 尚士, 田中 浩明, 六車 一哉, 高島 勉, 八代 正和, 前田 清, 小野田 尚佳, 仲田 文造, 大平 雅一, 石川 哲郎, 平川 弘聖

    一般社団法人日本外科学会 日本外科学会雑誌   113 ( 2 )   2012.03( ISSN:03014894

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  • PS-068-6 食道癌に対する術前治療のリンパ節微小転移個数に及ぼす効果(PS-068 食道 基礎・病理,第112回日本外科学会定期学術集会) Reviewed

    李 友浩, 田中 浩明, 森本 純也, 永原 央, 木村 健二郎, 天野 良亮, 野田 英児, 久保 尚士, 六車 一哉, 山田 靖哉, 八代 正和, 山下 好人, 前田 清, 澤田 鉄二, 仲田 文造, 大平 雅一, 平川 弘聖

    一般社団法人日本外科学会 日本外科学会雑誌   113 ( 2 )   2012.03( ISSN:03014894

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  • PS-063-2 術後合併症からみた胸部食道癌手術における腹腔鏡補助下胃管作成術(HALS)の有用性(PS-063 食道 術後合併症,第112回日本外科学会定期学術集会) Reviewed

    大平 雅一, 久保 尚士, 田中 浩明, 櫻井 克宜, 六車 一哉, 李 友浩, 永原 央, 木村 健二郎, 天野 良亮, 野田 英児, 八代 正和, 山田 靖哉, 前田 清, 山下 好人, 澤田 鉄二, 平川 弘聖

    一般社団法人日本外科学会 日本外科学会雑誌   113 ( 2 )   2012.03( ISSN:03014894

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  • PS-018-1 大腸癌同時性腹膜播種症例の臨床病理学的検討(PS-018 大腸 腹膜播種,ポスターセッション,第112回日本外科学会定期学術集会) Reviewed

    野田 英児, 前田 清, 永原 央, 井上 透, 木村 健二郎, 天野 良亮, 渋谷 雅常, 久保 尚士, 田中 浩明, 六車 一哉, 八代 正和, 山田 靖哉, 高島 勉, 小野田 尚佳, 仲田 文造, 川尻 成美, 西口 幸男, 大平 雅一, 石川 哲郎, 池原 照幸, 平川 弘聖

    一般社団法人日本外科学会 日本外科学会雑誌   113 ( 2 )   2012.03( ISSN:03014894

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  • PS-010-3 未分化型早期胃癌に対する組織型からみた外科治療戦略(PS-010 胃 手術適応-2,ポスターセッション,第112回日本外科学会定期学術集会) Reviewed

    田中 浩明, 六車 一哉, 櫻井 克宣, 永原 央, 木村 健二郎, 天野 良亮, 野田 英児, 久保 尚士, 山田 靖哉, 八代 正和, 山下 好人, 前田 清, 澤田 鉄二, 大平 雅一, 平川 弘聖

    一般社団法人日本外科学会 日本外科学会雑誌   113 ( 2 )   2012.03( ISSN:03014894

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  • PS-009-2 外科的切除を行なったstage IV胃癌患者の予後因子の検討(PS-009 胃 手術適応-1,ポスターセッション,第112回日本外科学会定期学術集会) Reviewed

    久保 尚士, 櫻井 克宣, 田中 浩明, 六車 一哉, 八代 正和, 澤田 鉄二, 山下 好人, 永原 央, 木村 健二郎, 天野 良亮, 野田 英児, 高島 勉, 山田 靖哉, 小野田 尚佳, 仲田 文造, 大平 雅一, 石川 哲郎, 平川 弘聖

    一般社団法人日本外科学会 日本外科学会雑誌   113 ( 2 )   2012.03( ISSN:03014894

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  • PS-008-7 胃癌によるCD11b陽性樹状細胞誘導の意義(PS-008 胃 基礎-4,ポスターセッション,第112回日本外科学会定期学術集会) Reviewed

    大北 仁裕, 田中 浩明, 岩内 武彦, 吉井 真実, 李 友浩, 久保 尚士, 六車 一哉, 永原 央, 木村 健二郎, 天野 良亮, 野田 英児, 山田 靖哉, 八代 正和, 前田 清, 澤田 鉄二, 大平 雅一, 平川 弘聖

    一般社団法人日本外科学会 日本外科学会雑誌   113 ( 2 )   2012.03( ISSN:03014894

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  • PS-007-8 胃癌における血清SPan-1およびCEA高値例の臨床病理学的意義(PS-007 胃 基礎-3,ポスターセッション,第112回日本外科学会定期学術集会) Reviewed

    森崎 珠実, 八代 正和, 大北 仁裕, 福岡 達成, 青松 直撥, 長谷川 毅, 平川 俊基, 吉井 真実, 松岡 順子, 木村 健二郎, 永原 央, 天野 良亮, 野田 英児, 久保 尚士, 田中 浩明, 六車 一哉, 山田 靖哉, 前田 清, 仲田 文造, 大平 雅一, 平川 弘聖

    一般社団法人日本外科学会 日本外科学会雑誌   113 ( 2 )   2012.03( ISSN:03014894

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  • PS-007-1 スキルス胃癌に対するプロスタグランジンE2受容体(EP2)阻害剤の有効性(PS-007 胃 基礎-3,ポスターセッション,第112回日本外科学会定期学術集会) Reviewed

    福岡 達成, 八代 正和, 森崎 珠実, 大北 仁裕, 青松 直撥, 長谷川 毅, 平川 俊基, 吉井 真実, 松岡 順子, 櫻井 克宣, 天野 良亮, 野田 英児, 久保 尚士, 田中 浩明, 六車 一哉, 山田 靖哉, 前田 清, 仲田 文造, 大平 雅一, 平川 弘聖

    一般社団法人日本外科学会 日本外科学会雑誌   113 ( 2 )   2012.03( ISSN:03014894

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  • SF-023-2 乳癌術前化学療法における低酸素マーカーCarbonic anhydrase9の有用性(SF-023 サージカルフォーラム(23)乳腺 基礎-1,第112回日本外科学会定期学術集会) Reviewed

    青松 直撥, 八代 正和, 森崎 珠実, 福岡 達成, 平川 俊基, 長谷川 毅, 松岡 順子, 柏木 伸一郎, 高島 勉, 川尻 成美, 小野田 尚佳, 石川 哲郎, 平川 弘聖

    一般社団法人日本外科学会 日本外科学会雑誌   113 ( 2 )   2012.03( ISSN:03014894

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  • SF-093-3 大腸癌先進部における低分化胞巣の臨床的意義(SF-093 サージカルフォーラム(93)大腸 病理,第112回日本外科学会定期学術集会) Reviewed

    渋谷 雅常, 野田 英児, 前田 清, 永原 央, 井上 透, 川尻 成美, 木村 健二郎, 天野 良亮, 久保 尚士, 田中 浩明, 六車 一哉, 山田 靖哉, 八代 正和, 小野田 尚佳, 仲田 文造, 西口 幸雄, 大平 雅一, 石川 哲郎, 平川 弘聖

    一般社団法人日本外科学会 日本外科学会雑誌   113 ( 2 )   2012.03( ISSN:03014894

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  • SF-064-2 ニッチ線維芽細胞は胃癌幹細胞様SP細胞分画を増加させる(SF-064 サージカルフォーラム(64)胃 基礎-3,第112回日本外科学会定期学術集会) Reviewed

    長谷川 毅, 八代 正和, 森崎 珠実, 福岡 達成, 平川 俊基, 青松 直撥, 吉井 真美, 松岡 順子, 櫻井 克宣, 野田 英児, 天野 良亮, 久保 尚士, 田中 浩明, 六車 一哉, 山田 靖哉, 前田 清, 大平 雅一, 石川 哲郎, 平川 弘聖

    一般社団法人日本外科学会 日本外科学会雑誌   113 ( 2 )   2012.03( ISSN:03014894

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  • SF-064-1 腹腔内微小環境下における線維化メカニズムの解明とその制御(SF-064 サージカルフォーラム(64)胃 基礎-3,第112回日本外科学会定期学術集会) Reviewed

    伏田 幸夫, 寺井 志郎, 柄田 智也, 八木 康道, 木下 淳, 尾山 勝信, 岡本 浩一, 中村 慶史, 牧野 勇, 藤田 秀人, 田島 秀浩, 高村 博之, 二宮 致, 藤村 隆, 八代 正和, 平川 弘聖, 太田 哲生

    一般社団法人日本外科学会 日本外科学会雑誌   113 ( 2 )   2012.03( ISSN:03014894

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  • SF-034-1 膵頭十二指腸切除後の周術期および遠隔期合併症の検証(SF-034 サージカルフォーラム(34)膵 合併症-2,第112回日本外科学会定期学術集会) Reviewed

    天野 良亮, 山田 靖哉, 木村 健二郎, 村田 哲洋, 櫻井 克宣, 平田 啓一郎, 松岡 順子, 川尻 成美, 永原 央, 野田 英児, 久保 尚士, 田中 浩明, 六車 一哉, 高島 勉, 八代 正和, 小野田 尚佳, 前田 清, 仲田 文造, 大平 雅一, 石川 哲郎, 平川 弘聖

    一般社団法人日本外科学会 日本外科学会雑誌   113 ( 2 )   2012.03( ISSN:03014894

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  • PS-005-5 低酸素環境下における胃癌細胞の上皮間葉転換(EMT)の機序と阻害剤の検討(PS-005 胃 基礎-1,ポスターセッション,第112回日本外科学会定期学術集会) Reviewed

    松岡 順子, 八代 正和, 青松 直撥, 平川 俊基, 長谷川 毅, 久保 尚士, 田中 浩明, 六車 一哉, 山田 靖哉, 大平 雅一, 石川 哲郎, 平川 弘聖

    日本外科学会雑誌   113 ( 2 )   503   2012.03( ISSN:03014894

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  • VD-009-5 腹腔鏡下大腸癌手術における縫合不全ゼロを目指したDST吻合法の工夫(VD-009 ビデオセッション(9)直腸 鏡視下-1,第112回日本外科学会定期学術集会) Reviewed

    永原 央, 前田 清, 野田 英児, 渋谷 雅常, 木村 健二郎, 天野 良亮, 久保 尚士, 田中 浩明, 六車 一哉, 山田 靖哉, 八代 正和, 仲田 文造, 大平 雅一, 石川 哲郎, 平川 弘聖

    日本外科学会雑誌   113 ( 2 )   463   2012.03( ISSN:03014894

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  • SF-093-3 大腸癌先進部における低分化胞巣の臨床的意義(SF-093 サージカルフォーラム(93)大腸 病理,第112回日本外科学会定期学術集会) Reviewed

    渋谷 雅常, 野田 英児, 前田 清, 永原 央, 井上 透, 川尻 成美, 木村 健二郎, 天野 良亮, 久保 尚士, 田中 浩明, 六車 一哉, 山田 靖哉, 八代 正和, 小野田 尚佳, 仲田 文造, 西口 幸雄, 大平 雅一, 石川 哲郎, 平川 弘聖

    日本外科学会雑誌   113 ( 2 )   411   2012.03( ISSN:03014894

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  • SF-064-2 ニッチ線維芽細胞は胃癌幹細胞様SP細胞分画を増加させる(SF-064 サージカルフォーラム(64)胃 基礎-3,第112回日本外科学会定期学術集会) Reviewed

    長谷川 毅, 八代 正和, 森崎 珠実, 福岡 達成, 平川 俊基, 青松 直撥, 吉井 真美, 松岡 順子, 櫻井 克宣, 野田 英児, 天野 良亮, 久保 尚士, 田中 浩明, 六車 一哉, 山田 靖哉, 前田 清, 大平 雅一, 石川 哲郎, 平川 弘聖

    日本外科学会雑誌   113 ( 2 )   371   2012.03( ISSN:03014894

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  • SF-064-1 腹腔内微小環境下における線維化メカニズムの解明とその制御(SF-064 サージカルフォーラム(64)胃 基礎-3,第112回日本外科学会定期学術集会) Reviewed

    伏田 幸夫, 寺井 志郎, 柄田 智也, 八木 康道, 木下 淳, 尾山 勝信, 岡本 浩一, 中村 慶史, 牧野 勇, 藤田 秀人, 田島 秀浩, 高村 博之, 二宮 致, 藤村 隆, 八代 正和, 平川 弘聖, 太田 哲生

    日本外科学会雑誌   113 ( 2 )   371   2012.03( ISSN:03014894

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  • SF-034-1 膵頭十二指腸切除後の周術期および遠隔期合併症の検証(SF-034 サージカルフォーラム(34)膵 合併症-2,第112回日本外科学会定期学術集会) Reviewed

    天野 良亮, 山田 靖哉, 木村 健二郎, 村田 哲洋, 櫻井 克宣, 平田 啓一郎, 松岡 順子, 川尻 成美, 永原 央, 野田 英児, 久保 尚士, 田中 浩明, 六車 一哉, 高島 勉, 八代 正和, 小野田 尚佳, 前田 清, 仲田 文造, 大平 雅一, 石川 哲郎, 平川 弘聖

    日本外科学会雑誌   113 ( 2 )   329   2012.03( ISSN:03014894

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  • SF-023-2 乳癌術前化学療法における低酸素マーカーCarbonic anhydrase9の有用性(SF-023 サージカルフォーラム(23)乳腺 基礎-1,第112回日本外科学会定期学術集会) Reviewed

    青松 直撥, 八代 正和, 森崎 珠実, 福岡 達成, 平川 俊基, 長谷川 毅, 松岡 順子, 柏木 伸一郎, 高島 勉, 川尻 成美, 小野田 尚佳, 石川 哲郎, 平川 弘聖

    日本外科学会雑誌   113 ( 2 )   315   2012.03( ISSN:03014894

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  • PS-148-7 膵癌におけるIGF1R発現と予後の相関関係(PS-148 膵 基礎-2,ポスターセッション,第112回日本外科学会定期学術集会) Reviewed

    平川 俊基, 八代 正和, 森崎 珠実, 福岡 達成, 吉井 真美, 長谷川 毅, 青松 直撥, 松岡 順子, 村田 哲洋, 木村 健二郎, 永原 央, 天野 良亮, 野田 英児, 久保尚士, 久保 尚士, 田中 浩明, 六車 一哉, 山田 靖哉, 前田 清, 仲田 文造, 大平 雅一, 平川 弘聖

    日本外科学会雑誌   113 ( 2 )   788   2012.03( ISSN:03014894

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  • PS-129-5 胃癌リンパ節転移は,HLA class I発現低下と相関する(PS-129 胃 基礎-5,ポスターセッション,第112回日本外科学会定期学術集会) Reviewed

    吉井 真美, 田中 浩明, 木村 健二郎, 永原 央, 天野 良亮, 野田 英児, 久保 尚士, 六車 一哉, 山田 靖哉, 八代 正和, 前田 清, 澤田 鉄二, 大平 雅一, 石川 哲郎, 平川 弘聖

    日本外科学会雑誌   113 ( 2 )   750   2012.03( ISSN:03014894

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  • PS-128-1 長期成績からみた胃癌幽門側切除後消化管再建法についての検討(PS-128 胃 手術手技,ポスターセッション,第112回日本外科学会定期学術集会) Reviewed

    六車 一哉, 田中 浩明, 櫻井 克宣, 久保 尚士, 木村 健二郎, 永原 央, 天野 良亮, 野田 英児, 八代 正和, 山田 靖哉, 山下 好人, 前田 清, 澤田 鉄二, 大平 雅一, 平川 弘聖

    日本外科学会雑誌   113 ( 2 )   747   2012.03( ISSN:03014894

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  • PS-124-8 原発性十二指腸癌切除例の検討(PS-124 胃 臨床,ポスターセッション,第112回日本外科学会定期学術集会) Reviewed

    平田 啓一郎, 天野 良亮, 山田 靖哉, 木村 健二郎, 村田 哲洋, 櫻井 克宣, 川尻 成美, 永原 央, 野田 英児, 久保 尚士, 田中 浩明, 六車 一哉, 高島 勉, 八代 正和, 前田 清, 小野田 尚佳, 仲田 文造, 大平 雅一, 石川 哲郎, 平川 弘聖

    日本外科学会雑誌   113 ( 2 )   740   2012.03( ISSN:03014894

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  • PS-068-6 食道癌に対する術前治療のリンパ節微小転移個数に及ぼす効果(PS-068 食道 基礎・病理,第112回日本外科学会定期学術集会) Reviewed

    李 友浩, 田中 浩明, 森本 純也, 永原 央, 木村 健二郎, 天野 良亮, 野田 英児, 久保 尚士, 六車 一哉, 山田 靖哉, 八代 正和, 山下 好人, 前田 清, 澤田 鉄二, 仲田 文造, 大平 雅一, 平川 弘聖

    日本外科学会雑誌   113 ( 2 )   628   2012.03( ISSN:03014894

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  • PS-063-2 術後合併症からみた胸部食道癌手術における腹腔鏡補助下胃管作成術(HALS)の有用性(PS-063 食道 術後合併症,第112回日本外科学会定期学術集会) Reviewed

    大平 雅一, 久保 尚士, 田中 浩明, 櫻井 克宜, 六車 一哉, 李 友浩, 永原 央, 木村 健二郎, 天野 良亮, 野田 英児, 八代 正和, 山田 靖哉, 前田 清, 山下 好人, 澤田 鉄二, 平川 弘聖

    日本外科学会雑誌   113 ( 2 )   617   2012.03( ISSN:03014894

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  • PS-018-1 大腸癌同時性腹膜播種症例の臨床病理学的検討(PS-018 大腸 腹膜播種,ポスターセッション,第112回日本外科学会定期学術集会) Reviewed

    野田 英児, 前田 清, 永原 央, 井上 透, 木村 健二郎, 天野 良亮, 渋谷 雅常, 久保 尚士, 田中 浩明, 六車 一哉, 八代 正和, 山田 靖哉, 高島 勉, 小野田 尚佳, 仲田 文造, 川尻 成美, 西口 幸男, 大平 雅一, 石川 哲郎, 池原 照幸, 平川 弘聖

    日本外科学会雑誌   113 ( 2 )   528   2012.03( ISSN:03014894

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    CiNii Article

  • PS-010-3 未分化型早期胃癌に対する組織型からみた外科治療戦略(PS-010 胃 手術適応-2,ポスターセッション,第112回日本外科学会定期学術集会) Reviewed

    田中 浩明, 六車 一哉, 櫻井 克宣, 永原 央, 木村 健二郎, 天野 良亮, 野田 英児, 久保 尚士, 山田 靖哉, 八代 正和, 山下 好人, 前田 清, 澤田 鉄二, 大平 雅一, 平川 弘聖

    日本外科学会雑誌   113 ( 2 )   512   2012.03( ISSN:03014894

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  • PS-009-2 外科的切除を行なったstage IV胃癌患者の予後因子の検討(PS-009 胃 手術適応-1,ポスターセッション,第112回日本外科学会定期学術集会) Reviewed

    久保 尚士, 櫻井 克宣, 田中 浩明, 六車 一哉, 八代 正和, 澤田 鉄二, 山下 好人, 永原 央, 木村 健二郎, 天野 良亮, 野田 英児, 高島 勉, 山田 靖哉, 小野田 尚佳, 仲田 文造, 大平 雅一, 石川 哲郎, 平川 弘聖

    日本外科学会雑誌   113 ( 2 )   510   2012.03( ISSN:03014894

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  • PS-008-7 胃癌によるCD11b陽性樹状細胞誘導の意義(PS-008 胃 基礎-4,ポスターセッション,第112回日本外科学会定期学術集会) Reviewed

    大北 仁裕, 田中 浩明, 岩内 武彦, 吉井 真実, 李 友浩, 久保 尚士, 六車 一哉, 永原 央, 木村 健二郎, 天野 良亮, 野田 英児, 山田 靖哉, 八代 正和, 前田 清, 澤田 鉄二, 大平 雅一, 平川 弘聖

    日本外科学会雑誌   113 ( 2 )   509   2012.03( ISSN:03014894

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  • PS-007-8 胃癌における血清SPan-1およびCEA高値例の臨床病理学的意義(PS-007 胃 基礎-3,ポスターセッション,第112回日本外科学会定期学術集会) Reviewed

    森崎 珠実, 八代 正和, 大北 仁裕, 福岡 達成, 青松 直撥, 長谷川 毅, 平川 俊基, 吉井 真実, 松岡 順子, 木村 健二郎, 永原 央, 天野 良亮, 野田 英児, 久保 尚士, 田中 浩明, 六車 一哉, 山田 靖哉, 前田 清, 仲田 文造, 大平 雅一, 平川 弘聖

    日本外科学会雑誌   113 ( 2 )   507   2012.03( ISSN:03014894

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  • PS-007-1 スキルス胃癌に対するプロスタグランジンE2受容体(EP2)阻害剤の有効性(PS-007 胃 基礎-3,ポスターセッション,第112回日本外科学会定期学術集会) Reviewed

    福岡 達成, 八代 正和, 森崎 珠実, 大北 仁裕, 青松 直撥, 長谷川 毅, 平川 俊基, 吉井 真実, 松岡 順子, 櫻井 克宣, 天野 良亮, 野田 英児, 久保 尚士, 田中 浩明, 六車 一哉, 山田 靖哉, 前田 清, 仲田 文造, 大平 雅一, 平川 弘聖

    日本外科学会雑誌   113 ( 2 )   506   2012.03( ISSN:03014894

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  • Identification of New HLA-A_*2402 Restricted Peptide Expressed in Scirrhous Gastric Cancer Reviewed

    TANAKA Hiroaki, IWAUCHI Takehiko, MUGURUMA Kazuya, YOSHII Mami, KUBO Naoshi, YASHIRO Masakazu, SAWADA Tetsuji, OHIRA Masaichi, HIRAKAWA Kosei

    37 ( 1 )   36 - 40   2012.02( ISSN:03857883

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  • Identification of New HLA-A_*2402 Restricted Peptide Expressed in Scirrhous Gastric Cancer Reviewed

    TANAKA Hiroaki, IWAUCHI Takehiko, MUGURUMA Kazuya, YOSHII Mami, KUBO Naoshi, YASHIRO Masakazu, SAWADA Tetsuji, OHIRA Masaichi, HIRAKAWA Kosei

    37 ( 1 )   36 - 40   2012.02( ISSN:03857883

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  • Plasminogen activator inhibitor 1 RNAi suppresses gastric cancer metastasis in vivo Reviewed

    Nishioka Nobuaki, Matsuoka Tasuku, Yashiro Masakazu, Hirakawa Kosei, Olden Kenneth, Roberts John D.

    CANCER SCIENCE   103 ( 2 )   228 - 232   2012.02( ISSN:1349-7006

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    DOI: 10.1111/j.1349-7006.2011.02155.x

    PubMed

  • Plasminogen activator inhibitor 1 RNAi suppresses gastric cancer metastasis in vivo Reviewed

    Nobuaki Nishioka, Tasuku Matsuoka, Masakazu Yashiro, Kosei Hirakawa, Kenneth Olden, John D. Roberts

    CANCER SCIENCE   103 ( 2 )   228 - 232   2012.02( ISSN:1347-9032

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    Cancer metastasis remains the primary cause of pain, suffering, and death in cancer patients, and even the most current therapeutic strategies have not been highly successful in preventing or inhibiting metastasis. In most patients with scirrhous gastric cancer (one of the most aggressive of diffuse-type gastric cancer), recurrence occurs even after potentially curative resection, most frequently in the form of peritoneal metastasis. Given that the occurrence of diffuse-type gastric cancers has been increasing, the development of new strategies to combat metastasis of this disease is critically important. Plasminogen activator inhibitor-1 (PAI-1) is a critical factor in cancer progression; thus, PAI-1 RNAi may be an effective therapy against cancer metastasis. In the present study, we used an RNAi technique to reduce PAI-1 expression in an in vivo model system for gastric cancer metastasis. Ex vivo plasmid transfection and adenovirus infection were tested as mechanisms to incorporate specific PAI-1 RNAi vectors into human gastric carcinoma cells. Both approaches significantly decreased peritoneal tumor growth and the formation of bloody ascites in the mouse model, suggesting that this approach may provide a new, effective strategy for inhibiting cancer metastasis. (Cancer Sci 2012; 103: 228232)

    DOI: 10.1111/j.1349-7006.2011.02155.x

    PubMed

  • プラスミノゲンアクチベーターインヒビター1 RNAiはin vivoで胃癌転移を抑制する(Plasminogen activator inhibitor 1 RNAi suppresses gastric cancer metastasis in vivo) Reviewed

    Nishioka Nobuaki, Matsuoka Tasuku, Yashiro Masakazu, Hirakawa Kosei, Olden Kenneth, Roberts John D.

    Cancer Science   103 ( 2 )   228 - 232   2012.02( ISSN:1347-9032

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    RNA干渉法(RNAi)を用いて胃癌転移のin vivoモデル系におけるプラスミノゲンアクチベーターインヒビター1(PAI-1)発現を抑制した。ヒト胃癌細胞への特異的PAI-1 RNAiベクターの取り込みのメカニズムとして、ex vivoのプラスミドトランスフェクションおよびアデノウイルス感染を調べた。マウスモデルにおいて、両アプローチとも腹膜腫瘍増殖および血性腹水を抑制し、本アプローチが癌転移阻害のための新しい有効な方法であることが示唆された。

  • 胃癌の進展におけるHLA class I発現低下とHLA-A遺伝子のloss of heterozygosity(LOH) Reviewed

    吉井 真美, 田中 浩明, 木村 健二郎, 永原 央, 天野 良亮, 野田 英児, 久保 尚士, 六車 一哉, 山田 靖哉, 八代 正和, 前田 清, 澤田 鉄二, 大平 雅一, 石川 哲郎, 平川 弘聖

    日本胃癌学会総会記事   84回   278 - 278   2012.02

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  • 胃癌細胞による樹状細胞phenotypeの変化 Reviewed

    大北 仁裕, 田中 浩明, 岩内 武彦, 久保 尚士, 六車 一哉, 永原 央, 木村 健二郎, 天野 良亮, 野田 英児, 山田 靖哉, 八代 正和, 前田 清, 澤田 鉄二, 大平 雅一, 平川 弘聖

    日本胃癌学会総会記事   84回   277 - 277   2012.02

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  • Predictive Value of Expression of ERCC 1 and GST-p for 5-Fluorouracil/Oxaliplatin Chemotheraphy in Advanced Colorectal Cancer Reviewed

    Eiji Noda, Kiyoshi Maeda, Toru Inoue, Shinya Fukunaga, Hisashi Nagahara, Masatsune Shibutani, Ryosuke Amano, Bunzo Nakata, Hiroaki Tanaka, Kazuya Muguruma, Nobuya Yamada, Masakazu Yashiro, Masaichi Ohira, Tetsuro Ishikawa, Kosei Hirakawa

    HEPATO-GASTROENTEROLOGY   59 ( 113 )   130 - 3   2012.01( ISSN:0172-6390

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    Background/Aims: The aim of this study was to determine whether expression of the excision repair cross complementing protein (ERCC1), glutathione S-transferase pi (GST-p) and thymidylate synthase (TS) predict response in patients with advanced colorectal cancer treated with 5-fluorouracil/oxaliplatin chemotherapy. Methodology: The study population consisted of 39 patients with advanced colorectal cancer (median age, 65 years). Patients were treated with the modified FOLFOX 6 regimen. The expression of ERCC-1, GST-p and TS of primary tumors were examined by immunohistochemistry. Results: The response rate of modified FOLFOX 6 chemotherapy was 51.3%. The positive rates of ERCC-1, GST-p and TS were 43.6%, 33.3% and 66.7%, respectively. The patients without ERCC-1 (p=0.0248) or GST-p (p=0.0019) expression were more likely to respond to chemotherapy. TS expression did not correlate with chemotherapeutic response. Conclusions: Immunohistochemical studies for ERCC-1 and GST-p may be useful in prediction of the response to 5-fluorouracil/oxaliplatin chemotherapy in advanced colorectal cancer patients.

    DOI: 10.5754/hge11022

    PubMed

  • Borrmann's Macroscopic Criteria and p-Smad2 Expression Are Useful Predictive Prognostic Markers for Cytology-Positive Gastric Cancer Patients without Overt Peritoneal Metastasis Reviewed

    Fukuoka Tatsunari, Yashiro Masakazu, Noda Satoru, Sakurai Katsunobu, Kubo Naoshi, Tanaka Hiroaki, Muguruma Kazuya, Ohira Masaichi, Hirakawa Kosei

    Japanese Society for Molecular Tumor Marker Research, Japan Journal of Molecular Tumor Marker Research   ( 27 )   41 - 42   2012

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    DOI: 10.11241/jsmtmr.27.41

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  • Predictive Value of Expression of ERCC 1 and GST-p for 5-Fluorouracil/Oxaliplatin Chemotheraphy in Advanced Colorectal Cancer Reviewed

    Noda Eiji, Maeda Kiyoshi, Inoue Toru, Fukunaga Shinya, Nagahara Hisashi, Shibutani Masatsune, Amano Ryosuke, Nakata Bunzo, Tanaka Hiroaki, Muguruma Kazuya, Yamada Nobuya, Yashiro Masakazu, Ohira Masaichi, Ishikawa Tetsuro, Hirakawa Kosei

    HEPATO-GASTROENTEROLOGY   59 ( 113 )   130 - 133   2012( ISSN:0172-6390

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    DOI: 10.5754/hge11022

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  • NC-6301, a polymeric micelle rationally optimized for effective release of docetaxel, is potent but is less toxic than native docetaxel in vivo Reviewed

    Harada Mitsunori, Iwata Caname, Saito Hiroyuki, Ishii Kenta, Hayashi Tatsuyuki, Yashiro Masakazu, Hirakawa Kosei, Miyazono Kohei, Kato Yasuki, Kano Mitsunobu R.

    INTERNATIONAL JOURNAL OF NANOMEDICINE   7   2713 - 2727   2012( ISSN:1178-2013

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    DOI: 10.2147/IJN.S31247

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  • Expression of E-cadherin and Kras mutation may be biomarker of Cetuximab based therapy in metastatic colorectal cancer Reviewed

    Nakamoto Kentaro, Nagahara Hisashi, Noda Eiji, Yashiro Masakazu, Maeda Kiyoshi, Ohira Masaichi, Ishikawa Tetsuro, Hirakawa Kosei

    Japanese Society for Molecular Tumor Marker Research, Japan Journal of Molecular Tumor Marker Research   ( 27 )   59 - 60   2012

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    DOI: 10.11241/jsmtmr.27.59

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  • Identification of New HLA-A*2402 Restricted Peptide Expressed in Scirrhous Gastric Cancer Reviewed

    Tanaka Hiroaki, Iwauchi Takehiko, Muguruma Kazuya, Yoshii Mami, Kubo Naoshi, Yashiro Masakazu, Sawada Tetsuji, Ohira Masaichi, Hirakawa Kosei

    Japanese College of Surgeons, Nihon Gekakei Rengo Gakkaishi (Journal of Japanese College of Surgeons)   37 ( 1 )   36 - 40   2012( ISSN:0385-7883

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    Scirrhous gastric cancer often develops in lymph nodes and metastasizes to the peritoneum, thus resulting in poor prognosis. Even aggressive surgical procedures and adjuvant chemotherapies have done little to improve the survival rates in patients with scirrhous gastric cancer. Hence, the development of novel therapeutic strategies is urgently required for the treatment of patients with advanced scirrhous gastric cancer. ERas is a recently identified oncogene involved in the tumorgenic growth of embryonic stem (ES) cells. We examined the significance of ERas expression in scirrhous gastric carcinoma, and the possibility of ERas as a tumor-associated antigen of gastric cancer for developing a cancer vaccine. ERas expression was determined in scirrhous gastric carcinoma specimens by immunohistochemical staining. To assess the possibility of the ERas protein as an anti-cancer vaccine target, we examined whether ERas for HLA-A-restricted epitope peptides were capable of eliciting cytotoxic T lymphocyte (CTL) activity. We successfully established CTL clones stimulated by HLA-A*2402-restricted ERas peptides (FALDDPSSL). These peptides have specific cytotoxicity against cancer cells that endogenously express ERas. Our results suggest that ERas is a novel tumor-associated antigen with the potential application to be a vaccine against scirrhous gastric cancer.

    DOI: 10.4030/jjcs.37.36

    CiNii Article

  • Significance of stemness factors, Oct3/4, Sox2 and Nanog, in gastric carcinoma Reviewed

    Matsuoka Junko, Ohira Masaichi, Ishikawa Tetsuro, Hirakawa Kosei, Yashiro Masakazu, Aomatsu Naoki, Hirakawa Toshiki, Hasegawa Tsuyoshi, Kubo Naoshi, Tanaka Hiroaki, Muguruma Kazuya, Yamada Nobuya

    Japanese Society for Molecular Tumor Marker Research, Japan Journal of Molecular Tumor Marker Research   ( 27 )   13 - 14   2012

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    DOI: 10.11241/jsmtmr.27.13

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  • Significance of CD133 for predictive maker in neoadjuvant chemotherapy of breast cancer Reviewed

    Aomatsu Naoki, Kawajiri Hidemi, Onoda Naoyoshi, Ishikawa Tetsuro, Hirakawa Kosei, Yashiro Masakazu, Morisaki Tamami, Fukuoka Tatsunari, Hirakawa Toshiki, Hasegawa Tsuyosi, Matsuoka Zyunko, Kashiwagi Shinichiro, Takashima Tsutomu

    Japanese Society for Molecular Tumor Marker Research, Japan Journal of Molecular Tumor Marker Research   ( 27 )   51 - 51   2012

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    DOI: 10.11241/jsmtmr.27.51

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  • A targeting molecule for scirrhous gastric cancer Reviewed

    Yashiro Masakazu, Tanaka Hiroaki, Muguruma Kazuya, Yamada Nobuya, Ohira Masaichi, Ishikawa Tetsuro, Hirakawa Kosei, Fukuoka Tatsunari, Morisaki Tamami, Aomatsu Naoki, Hirakawa Toshiki, Hasegawa Tsuyoshi, Matsuoka Junko, Sakurai Katsunobu, Kubo Naoshi

    Japanese Society for Molecular Tumor Marker Research, Japan Journal of Molecular Tumor Marker Research   ( 27 )   5 - 6   2012

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    DOI: 10.11241/jsmtmr.27.5

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  • Expression of E-cadherin and Kras mutation may be biomarker of Cetuximab based therapy in metastatic colorectal cancer Reviewed

    Nakamoto Kentaro, Nagahara Hisashi, Noda Eiji, Yashiro Masakazu, Maeda Kiyoshi, Ohira Masaichi, Ishikawa Tetsuro, Hirakawa Kosei

    Japan Journal of Molecular Tumor Marker Research   27   59 - 60   2012( eISSN:24338575

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    DOI: 10.11241/jsmtmr.27.59

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  • NC-6301, a polymeric micelle rationally optimized for effective release of docetaxel, is potent but is less toxic than native docetaxel in vivo Reviewed

    Mitsunori Harada, Caname Iwata, Hiroyuki Saito, Kenta Ishii, Tatsuyuki Hayashi, Masakazu Yashiro, Kosei Hirakawa, Kohei Miyazono, Yasuki Kato, Mitsunobu R. Kano

    International Journal of Nanomedicine   7   2713 - 2727   2012( ISSN:1176-9114

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    Drug release rate is an important factor in determining efficacy and toxicity of nanoscale drug delivery systems. However, optimization of the release rate in polymeric micellar nanoscale drug delivery systems has not been fully investigated. In this study NC-6301, a poly(ethylene glycol)-poly(aspartate) block copolymer with docetaxel (DTX) covalently bound via ester link, was synthesized with various numbers of DTX molecules bound to the polymer backbone. The number of DTX molecules was determined up to 14 to achieve an optimal release rate, based upon the authors' own pharmacokinetic model using known patient data. Efficacy and toxicity of the formulation was then tested in animals. When administered three times at 4-day intervals, the maximum tolerated doses of NC-6301 and native DTX were 50 and 10 mg/kg, respectively, in nude mice. Tissue distribution studies of NC-6301 in mice at 50 mg/kg revealed prolonged release of free DTX in the tumor for at least 120 hours, thus supporting its effectiveness. Furthermore, in cynomolgus monkeys, NC-6301 at 6 mg/kg three times at 2-week intervals showed marginal toxicity, whereas native DTX, at 3 mg/kg with the same schedule, induced significant decrease of food consumption and neutrophil count. NC-6301 at 50 mg/kg in mice also regressed a xenografted tumor of MDA-MB-231 human breast cancer. Native DTX, on the other hand, produced only transient and slight regression of the same tumor xenograft. NC-6301 also significantly inhibited growth of OCUM-2MLN human scirrhous gastric carcinoma in an orthotopic mouse model. Total weight of metastatic lymph nodes was also reduced. In conclusion, NC-6301 with an optimized release rate improved the potency of DTX while reducing its toxicity. 2012 Cárdenas et al, publisher and licensee Dove Medical Press Ltd.

    DOI: 10.2147/IJN.S31247

    PubMed

  • CD133 Is a Useful Surrogate Marker for Predicting Chemosensitivity to Neoadjuvant Chemotherapy in Breast Cancer Reviewed

    Naoki Aomatsu, Masakazu Yashiro, Shinichiro Kashiwagi, Tsutomu Takashima, Tetsuro Ishikawa, Masahiko Ohsawa, Kenichi Wakasa, Kosei Hirakawa

    PLOS ONE   7 ( 9 )   e45865   2012( ISSN:1932-6203

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    Background: Neoadjuvant chemotherapy (NAC) is a standard care regimen for patients with breast cancer. However, the pathologic complete response (pCR) rate remains at 30%. We hypothesized that a cancer stem cell marker may identify NAC-resistant patients, and evaluated CD133 and ALDH1 as a potential surrogate marker for breast cancer. The aim of this study was to find a surrogate maker to predict chemosensitivity of NAC for breast cancer.
    Methodology/Findings: A total of 102 patients with breast cancer were treated with NAC consisting of epirubicin followed by paclitaxel. Core needle biopsy (CNB) specimens and resected tumors were obtained from all patients before and after NAC, respectively. Chemosensitivity and prognostic potential of CD133 or ALDH1 expression was evaluated by immunohistochemistry. Clinical CR (cCR) and pCR rates were 18% (18/102) and 29% (30/102), respectively. Forty-seven (46%) patients had CD133-positive tumors before NAC, and CD133 expression was significantly associated with a low pCR rate (p = 0.035) and clinical non-responders. Multivariate analysis revealed that CD133 expression was significantly (p = 0.03) related to pCR. Recurrence was more frequent in patients with CD133-positive tumors (21/47, 45%) than that in patients with CD133-negative tumors (7/55, 13%). The number of patients with CD133-positive tumors (62%) after NAC was higher than that (46%) before NAC. Furthermore, most patients with CD133-positive tumors before NAC maintained the same status after NAC.
    Conclusion/Significance: CD133 before NAC might be a useful marker for predicting the effectiveness of NAC and recurrence of breast cancer after NAC.

    DOI: 10.1371/journal.pone.0045865

    PubMed

  • A targeting molecule for scirrhous gastric cancer Reviewed

    Yashiro Masakazu, Fukuoka Tatsunari, Morisaki Tamami, Aomatsu Naoki, Hirakawa Toshiki, Hasegawa Tsuyoshi, Matsuoka Junko, Sakurai Katsunobu, Kubo Naoshi, Tanaka Hiroaki, Muguruma Kazuya, Yamada Nobuya, Ohira Masaichi, Ishikawa Tetsuro, Hirakawa Kosei

    Japan Journal of Molecular Tumor Marker Research   27   5 - 6   2012( eISSN:24338575

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    DOI: 10.11241/jsmtmr.27.5

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  • Identification of New HLA-A*2402 Restricted Peptide Expressed in Scirrhous Gastric Cancer

    Tanaka Hiroaki, Iwauchi Takehiko, Muguruma Kazuya, Yoshii Mami, Kubo Naoshi, Yashiro Masakazu, Sawada Tetsuji, Ohira Masaichi, Hirakawa Kosei

    Nihon Gekakei Rengo Gakkaishi (Journal of Japanese College of Surgeons)   37 ( 1 )   36 - 40   2012( ISSN:03857883 ( eISSN:18829112

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    Scirrhous gastric cancer often develops in lymph nodes and metastasizes to the peritoneum, thus resulting in poor prognosis. Even aggressive surgical procedures and adjuvant chemotherapies have done little to improve the survival rates in patients with scirrhous gastric cancer. Hence, the development of novel therapeutic strategies is urgently required for the treatment of patients with advanced scirrhous gastric cancer. ERas is a recently identified oncogene involved in the tumorgenic growth of embryonic stem (ES) cells. We examined the significance of ERas expression in scirrhous gastric carcinoma, and the possibility of ERas as a tumor-associated antigen of gastric cancer for developing a cancer vaccine. ERas expression was determined in scirrhous gastric carcinoma specimens by immunohistochemical staining. To assess the possibility of the ERas protein as an anti-cancer vaccine target, we examined whether ERas for HLA-A-restricted epitope peptides were capable of eliciting cytotoxic T lymphocyte (CTL) activity. We successfully established CTL clones stimulated by HLA-A*2402-restricted ERas peptides (FALDDPSSL). These peptides have specific cytotoxicity against cancer cells that endogenously express ERas. Our results suggest that ERas is a novel tumor-associated antigen with the potential application to be a vaccine against scirrhous gastric cancer.

    DOI: 10.4030/jjcs.37.36

    CiNii Article

  • Borrmann's Macroscopic Criteria and p-Smad2 Expression Are Useful Predictive Prognostic Markers for Cytology-Positive Gastric Cancer Patients without Overt Peritoneal Metastasis Reviewed

    Fukuoka Tatsunari, Yashiro Masakazu, Noda Satoru, Sakurai Katsunobu, Kubo Naoshi, Tanaka Hiroaki, Muguruma Kazuya, Ohira Masaichi, Hirakawa Kosei

    Japan Journal of Molecular Tumor Marker Research   27   41 - 42   2012( eISSN:24338575

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    DOI: 10.11241/jsmtmr.27.41

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  • Significance of CD133 for predictive maker in neoadjuvant chemotherapy of breast cancer Reviewed

    Aomatsu Naoki, Yashiro Masakazu, Morisaki Tamami, Fukuoka Tatsunari, Hirakawa Toshiki, Hasegawa Tsuyosi, Matsuoka Zyunko, Kashiwagi Shinichiro, Takashima Tsutomu, Kawajiri Hidemi, Onoda Naoyoshi, Ishikawa Tetsuro, Hirakawa Kosei

    Japan Journal of Molecular Tumor Marker Research   27   51 - 51   2012( eISSN:24338575

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    DOI: 10.11241/jsmtmr.27.51

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  • Polymeric micelles incorporating (1,2-diaminocyclohexane)platinum (II) suppress the growth of orthotopic scirrhous gastric tumors and their lymph node metastasis Reviewed

    Rafi M, Cabral H, Kano M.R, Mi P, Iwata C, Yashiro M, Hirakawa K, Miyazono K, Nishiyama N, Kataoka K

    Journal of Controlled Release   159 ( 2 )   189 - 196   2012

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    DOI: 10.1016/j.jconrel.2012.01.038

    Other URL: http://orcid.org/0000-0003-1593-1855

  • Significance of stemness factors, Oct3/4, Sox2 and Nanog, in gastric carcinoma Reviewed

    Matsuoka Junko, Yashiro Masakazu, Aomatsu Naoki, Hirakawa Toshiki, Hasegawa Tsuyoshi, Kubo Naoshi, Tanaka Hiroaki, Muguruma Kazuya, Yamada Nobuya, Ohira Masaichi, Ishikawa Tetsuro, Hirakawa Kosei

    Japan Journal of Molecular Tumor Marker Research   27   13 - 14   2012( eISSN:24338575

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.11241/jsmtmr.27.13

    CiNii Article

  • The utility of double balloon endoscopy in surgery. Reviewed

    66 ( 13 )   1610 - 1613   2011.12( ISSN:03869857 ( eISSN:18821278

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    DOI: 10.11477/mf.1407103867

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  • Borrmann's Macroscopic Criteria and p-Smad2 Expression Are Useful Predictive Prognostic Markers for Cytology-Positive Gastric Cancer Patients Without Overt Peritoneal Metastasis Reviewed

    Noda Satoru, Yashiro Masakazu, Toyokawa Takahiro, Morimoto Jyunya, Shinto Osamu, Muguruma Kazuya, Sawada Tetsuji, Hirakawa Kosei

    ANNALS OF SURGICAL ONCOLOGY   18 ( 13 )   3718 - 3725   2011.12( ISSN:1068-9265

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    DOI: 10.1245/s10434-011-1768-2

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  • Bone Morphogenetic Protein-2 and-4 Play Tumor Suppressive Roles in Human Diffuse-Type Gastric Carcinoma Reviewed

    Shirai Yo-taro, Ehata Shogo, Yashiro Masakazu, Yanagihara Kazuyoshi, Hirakawa Kosei, Miyazono Kohei

    AMERICAN JOURNAL OF PATHOLOGY   179 ( 6 )   2920 - 2930   2011.12( ISSN:0002-9440

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    DOI: 10.1016/j.ajpath.2011.08.022

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  • Bone Morphogenetic Protein-2 and-4 Play Tumor Suppressive Roles in Human Diffuse-Type Gastric Carcinoma Reviewed

    Yo-taro Shirai, Shogo Ehata, Masakazu Yashiro, Kazuyoshi Yanagihara, Kosei Hirakawa, Kohei Miyazono

    AMERICAN JOURNAL OF PATHOLOGY   179 ( 6 )   2920 - 2930   2011.12( ISSN:0002-9440

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    A relationship exists between defects in bone morphogenetic protein (BMP) signaling and formation of hamartoma and adenoma in the gastric epithelium; however, the role of BMP signaling in the progression of diffuse-type gastric carcinoma remains unknown. We investigated whether BMP functions as a tumor suppressor in human diffuse type gastric carcinoma using three different human diffuse-type gastric carcinoma cell lines (OCUM-12, HSC-39, and OCUM2MLN). Overexpression of the dominant-negative form of BMP-2/4-specific type 1 receptor (ALK-3) in OCUM-12 and HSC-39 cells accelerated their growth in vivo. BMP-4 induced cell cycle arrest in these cells via p21 induction through the SMAD pathway. Moreover, overexpression of the constitutively active form of ALK-3 in HSC-39 and OCUM-2MLN cells suppressed the proliferation of these cells in vitro and in vivo. Our findings suggest that BMP-2 and BMP-4 function as potent tumor suppressors in diffuse-type gastric carcinoma. (Am J Pathol 2011, 179:2920-2930; DOI: 10.1016/j.ajpath.2011.08.022)

    DOI: 10.1016/j.ajpath.2011.08.022

    PubMed

  • Borrmann&apos;s Macroscopic Criteria and p-Smad2 Expression Are Useful Predictive Prognostic Markers for Cytology-Positive Gastric Cancer Patients Without Overt Peritoneal Metastasis Reviewed

    Satoru Noda, Masakazu Yashiro, Takahiro Toyokawa, Jyunya Morimoto, Osamu Shinto, Kazuya Muguruma, Tetsuji Sawada, Kosei Hirakawa

    ANNALS OF SURGICAL ONCOLOGY   18 ( 13 )   3718 - 25   2011.12( ISSN:1068-9265

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    Background. All patients with peritoneal-free cancer cells (CY1) do not always develop a peritoneal recurrence (P1). The goal of this study was to identify characteristic features of peritoneal-free cancer cells that could develop into peritoneal recurrence.
    Methods. Of 1,474 patients, 91 were identified with CY1P0, and the remaining 1,383 with CY0P0. Immunohistochemical staining with anti-phosphorylated Smad 2 (p-Smad2) was performed on paraffin-embedded specimens from the 91 CY1P0 patients.
    Results. CY1 was significantly correlated with Borrmann&apos;s type-4 cancer, clinical T stage, and lymph node metastasis. CY1P0 patients with Borrmann&apos;s type-4 cancer more frequently develop peritoneal recurrence than do those with other types of tumors. The 5-year survival rate of patients with Borrmann&apos;s type-4 tumors was significantly (p = 0.023) low (6.3%) compared with that of patients with other types of tumors (27.7%). The prognosis for p-Smad2-positive patients was significantly poorer than that of p-Smad2-negative patients. In CY1 and/or P1 patients with Borrmann&apos;s type-4 tumors, no significant difference in prognosis was identified between those who had surgery and those who did not.
    Conclusions. Activated Smad signaling might be associated with a high potential for peritoneal recurrence in CY1P0 patients. Borrmann&apos;s macroscopic criteria and p-Smad2 expression are useful markers for surgeons selecting advanced gastric cancer patients with CY1P0 for gastrectomy.

    DOI: 10.1245/s10434-011-1768-2

    PubMed

  • Linoleic acid enhances angiogenesis through suppression of angiostatin induced by plasminogen activator inhibitor 1 Reviewed

    Nishioka N., Matsuoka T., Yashiro M., Hirakawa K., Olden K., Roberts J. D.

    BRITISH JOURNAL OF CANCER   105 ( 11 )   1750 - 1758   2011.11( ISSN:0007-0920

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    DOI: 10.1038/bjc.2011.434

  • An EGFR inhibitor enhances the efficacy of SN38, an active metabolite of irinotecan, in SN38-refractory gastric carcinoma cells Reviewed

    Yashiro M., Qiu H., Hasegawa T., Zhang X., Matsuzaki T., Hirakawa K.

    BRITISH JOURNAL OF CANCER   105 ( 10 )   1522 - 1532   2011.11( ISSN:0007-0920

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    DOI: 10.1038/bjc.2011.397

  • An EGFR inhibitor enhances the efficacy of SN38, an active metabolite of irinotecan, in SN38-refractory gastric carcinoma cells. Reviewed

    Yashiro M, Qiu H, Hasegawa T, Zhang X, Matsuzaki T, Hirakawa K

    British journal of cancer   105 ( 10 )   1522 - 32   2011.11( ISSN:0007-0920

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    DOI: 10.1038/bjc.2011.397

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  • [Salvage esophagectomy after definitive chemoradiation therapy]. Reviewed

    Kubo N, Tanaka H, Sakurai K, Muguruma K, Nagahara H, Kimura K, Noda E, Amano R, Yamada N, Yashiro M, Maeda K, Ohira M, Hirakawa K

    Gan to kagaku ryoho. Cancer & chemotherapy   38 ( 12 )   1948 - 50   2011.11( ISSN:0385-0684

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  • [Our experience of the treatment with XELOX±Bevacizumab for unresectable advanced colorectal cancer]. Reviewed

    Kashiwagi S, Maeda K, Fuyuhiro Y, Nagahara H, Kimura K, Amano R, Noda E, Kubo N, Tanaka H, Muguruma K, Yashiro M, Yamada N, Nakata B, Ohira M, Ishikawa T, Hirakawa K

    Gan to kagaku ryoho. Cancer & chemotherapy   38 ( 12 )   1936 - 8   2011.11( ISSN:0385-0684

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  • [A case of long-term survival after undergoing S-1 based multidisciplinary therapy for liver metastasis of gastric cancer]. Reviewed

    Ito G, Kubo N, Tanaka H, Muguruma K, Sakurai K, Kimura K, Nagahara H, Noda E, Amano R, Yamada N, Yashiro M, Maeda K, Sawada T, Nakata B, Ohira M, Hirakawa K

    Gan to kagaku ryoho. Cancer & chemotherapy   38 ( 12 )   2348 - 50   2011.11( ISSN:0385-0684

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  • [A case of long-term survival after undergoing S-1 based multidisciplinary therapy for liver metastasis of gastric cancer]. Reviewed

    Ito G, Kubo N, Tanaka H, Muguruma K, Sakurai K, Kimura K, Nagahara H, Noda E, Amano R, Yamada N, Yashiro M, Maeda K, Sawada T, Nakata B, Ohira M, Hirakawa K

    Gan to kagaku ryoho. Cancer & chemotherapy   38 ( 12 )   2348 - 2350   2011.11( ISSN:0385-0684

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  • [A case of long-term survival after undergoing S-1 based multidisciplinary therapy for liver metastasis of gastric cancer]. Reviewed

    Ito G, Kubo N, Tanaka H, Muguruma K, Sakurai K, Kimura K, Nagahara H, Noda E, Amano R, Yamada N, Yashiro M, Maeda K, Sawada T, Nakata B, Ohira M, Hirakawa K

    Gan to kagaku ryoho. Cancer & chemotherapy   38 ( 12 )   2348 - 50   2011.11( ISSN:0385-0684

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  • [Our experience of the treatment with XELOX±Bevacizumab for unresectable advanced colorectal cancer]. Reviewed

    Kashiwagi S, Maeda K, Fuyuhiro Y, Nagahara H, Kimura K, Amano R, Noda E, Kubo N, Tanaka H, Muguruma K, Yashiro M, Yamada N, Nakata B, Ohira M, Ishikawa T, Hirakawa K

    Gan to kagaku ryoho. Cancer & chemotherapy   38 ( 12 )   1936 - 8   2011.11( ISSN:0385-0684

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  • S-1を中心とした集学的療法にて長期生存している胃癌肝転移の1例 Reviewed

    伊藤 厳太郎, 久保 尚士, 田中 浩明, 六車 一哉, 櫻井 克宣, 木村 健二郎, 永原 央, 野田 英児, 天野 良亮, 山田 靖哉, 八代 正和, 前田 清, 澤田 鉄二, 仲田 文造, 大平 雅一, 平川 弘聖

    癌と化学療法   38 ( 12 )   2348 - 2350   2011.11( ISSN:0385-0684

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    症例は68歳、女性。胃癌同時性肝転移に対しS-1を2コース投与後、原発巣および肝転移巣の縮小を認め、肝部分切除、胃切除を施行した。術後11ヵ月に異時性肝転移を認めたため、S-1/CDDP療法を施行した。5コース施行後肝転移が消失し、化学療法を中止した後も術後8年間無再発生存中である。本症例では、原発巣でのフッ化ピリミジン系悪性腫瘍剤の標的酵素であるthymidylate synthetase(TS)抗体染色が陰性であり、5-FU系抗腫瘍薬に対しての感受性が高かった可能性が考えられた。TS染色はS-1を中心とする集学的治療の有益なマーカーになる可能性が示唆された。(著者抄録)

  • [Salvage esophagectomy after definitive chemoradiation therapy]. Reviewed

    Kubo N, Tanaka H, Sakurai K, Muguruma K, Nagahara H, Kimura K, Noda E, Amano R, Yamada N, Yashiro M, Maeda K, Ohira M, Hirakawa K

    Gan to kagaku ryoho. Cancer & chemotherapy   38 ( 12 )   1948 - 1950   2011.11( ISSN:0385-0684

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  • [Salvage esophagectomy after definitive chemoradiation therapy]. Reviewed

    Kubo N, Tanaka H, Sakurai K, Muguruma K, Nagahara H, Kimura K, Noda E, Amano R, Yamada N, Yashiro M, Maeda K, Ohira M, Hirakawa K

    Gan to kagaku ryoho. Cancer & chemotherapy   38 ( 12 )   1948 - 50   2011.11( ISSN:0385-0684

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    PubMed

  • [Our experience of the treatment with XELOX±Bevacizumab for unresectable advanced colorectal cancer]. Reviewed

    Kashiwagi S, Maeda K, Fuyuhiro Y, Nagahara H, Kimura K, Amano R, Noda E, Kubo N, Tanaka H, Muguruma K, Yashiro M, Yamada N, Nakata B, Ohira M, Ishikawa T, Hirakawa K

    Gan to kagaku ryoho. Cancer & chemotherapy   38 ( 12 )   1936 - 1938   2011.11( ISSN:0385-0684

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  • 切除不能進行再発結腸直腸癌に対するXELOX±Bevacizumab療法の治療経験 Reviewed

    柏木 伸一郎, 前田 清, 冬廣 雄彦, 永原 央, 木村 健二郎, 天野 良亮, 野田 英児, 久保 尚士, 田中 浩明, 六車 一哉, 八代 正和, 山田 靖哉, 仲田 文造, 大平 雅一, 石川 哲郎, 平川 弘聖

    癌と化学療法   38 ( 12 )   1936 - 1938   2011.11( ISSN:0385-0684

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    切除不能進行再発結腸直腸癌に対する化学療法はFOLFOXやFOLFIRIにbevacizumabを加えたものが標準治療である。海外第III相試験(NO16966)にてFOLFOXに対するXELOXの非劣性が示され、bevacizumabの上乗せ効果も確認された。当科で経験したXELOX±bevacizumabの治療成績、安全性について報告する。切除不能進行再発結腸直腸癌に対してXELOX±bevacizumabを使用した45症例を対象とした。CR:PR:SD:PD:NE=0:13:5:5:22で奏効率は56.5%、腫瘍抑制率は78.2%であった。そのうち一次治療で行った19例では奏効率80.0%、腫瘍抑制率は90.0%であった。有害事象は、手足症候群grade 2は6例(13.2%)、grade 3は3例(6.6%)で、1例で治療継続困難となった以外は減量や休薬で継続が可能であった。死亡例は認めなかった。XELOX±bevacizumabは、FOLFOXなどに比較して治療効果や安全性に劣らない治療法と考えられる。手足症候群などの有害事象に注意すればQOLを維持して継続治療が可能であった。(著者抄録)

  • Linoleic acid enhances angiogenesis through suppression of angiostatin induced by plasminogen activator inhibitor 1 Reviewed

    N. Nishioka, T. Matsuoka, M. Yashiro, K. Hirakawa, K. Olden, J. D. Roberts

    BRITISH JOURNAL OF CANCER   105 ( 11 )   1750 - 1758   2011.11( ISSN:0007-0920

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    BACKGROUND: The intake of dietary fatty acids is highly correlated with the risk of various cancers. Linoleic acid (LA) is the most abundant polyunsaturated fat in the western diet, but the mechanism(s) by fatty acids such as LA modulate cancer cells is unclear. In this study, we examined the role of LA in various steps in gastric cancer progression.
    METHODS: The difference in gene expression between LA-treated and untreated OCUM-2MD3 gastric carcinoma cells was examined by mRNA differential display. The involvement of candidate genes was examined by oligo-and plasmid-mediated RNA interference. Biological functions of several of these genes were examined using in vitro assays for invasion, angiogenesis, apoptosis, cell viability, and matrix digestion. Angiogenesis in vivo was measured by CD-31 immunohistochemistry and microvessel density scoring.
    RESULTS: LA enhanced the plasminogen activator inhibitor 1 (PAI-1) mRNA and protein expression, which are controlled by PAI-1 mRNA-binding protein. LA-stimulated invasion depended on PAI-1. LA also enhanced angiogenesis by suppression of angiostatin, also through PAI-1. LA did not alter cell growth in culture, but increased dietary LA-enhanced tumour growth in an animal model.
    CONCLUSION: Our findings suggest that dietary LA impacts multiple steps in cancer invasion and angiogenesis, and that reducing LA in the diet may help slow cancer progression. British Journal of Cancer (2011) 105, 1750-1758. doi:10.1038/bjc.2011.434 www.bjcancer.com

    DOI: 10.1038/bjc.2011.434

  • 食道癌に対する根治的化学放射線療法後の救済手術(Salvage Esophagectomy)例の検討 Reviewed

    久保 尚士, 田中 浩明, 櫻井 克宣, 六車 一哉, 永原 央, 木村 健二郎, 野田 英児, 天野 良亮, 山田 靖哉, 八代 正和, 前田 清, 大平 雅一, 平川 弘聖

    癌と化学療法   38 ( 12 )   1948 - 1950   2011.11( ISSN:0385-0684

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    近年、局所進行食道癌のみならず、切除可能食道癌にも50Gy以上を照射する根治的化学放射線療法(definitive CRT)が施行されている。そしてdefinitive CRT後に腫瘍の遺残、再発に対する救済手術(salvage esophagectomy:SE)が必要となる症例が増加している。教室で行ったSE群7例の手術成績を40Gy照射後の手術(PS)群、術前照射を行っていない手術単独(SA)群と比較検討した。縫合不全率はSE群43%、PS群3%、SA群7%とSE群が有意に高率であった。またSE群の肺合併症率は28%で、PS群15%、SA群15%と比較して高率であったが、有意差は認めなかった。在院死亡率は、SA群0%、PS群9%、SE群28%と放射線照射量に伴って増加した。合併症、死亡率の高いsalvage手術は十分な説明と同意の下に、確実にR0が可能な症例に対して行われるべきと考えられた。(著者抄録)

  • Effects of Acute and Chronic Hypoxia on the Radiosensitivity of Gastric and Esophageal Cancer Cells Reviewed

    Kato Yukihiro, Yashiro Masakazu, Fuyuhiro Yuhiko, Kashiwagi Shinichiro, Matsuoka Junko, Hirakawa Toshiki, Noda Satoru, Aomatsu Naoki, Hasegawa Tsuyoshi, Matsuzaki Taro, Sawada Tetsuji, Ohira Masaichi, Hirakawa Kosei

    ANTICANCER RESEARCH   31 ( 10 )   3369 - 3375   2011.10( ISSN:0250-7005

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  • THBS4, a novel stromal molecule of diffuse-type gastric adenocarcinomas, identified by transcriptome-wide expression profiling Reviewed

    Foerster Susann, Gretschel Stephan, Joens Thomas, Yashiro Masakazu, Kemmner Wolfgang

    MODERN PATHOLOGY   24 ( 10 )   1390 - 1403   2011.10( ISSN:0893-3952

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    DOI: 10.1038/modpathol.2011.99

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  • RhoA/ROCK signaling mediates plasticity of scirrhous gastric carcinoma motility Reviewed

    Matsuoka Tasuku, Yashiro Masakazu, Kato Yukihiro, Shinto Osamu, Kashiwagi Shinichiro, Hirakawa Kosei

    CLINICAL & EXPERIMENTAL METASTASIS   28 ( 7 )   627 - 636   2011.10( ISSN:0262-0898

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    DOI: 10.1007/s10585-011-9396-6

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  • Effects of acute and chronic hypoxia on the radiosensitivity of gastric and esophageal cancer cells. Reviewed

    Kato Y, Yashiro M, Fuyuhiro Y, Kashiwagi S, Matsuoka J, Hirakawa T, Noda S, Aomatsu N, Hasegawa T, Matsuzaki T, Sawada T, Ohira M, Hirakawa K

    Anticancer research   31 ( 10 )   3369 - 75   2011.10( ISSN:0250-7005

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  • Effects of Acute and Chronic Hypoxia on the Radiosensitivity of Gastric and Esophageal Cancer Cells Reviewed

    Yukihiro Kato, Masakazu Yashiro, Yuhiko Fuyuhiro, Shinichiro Kashiwagi, Junko Matsuoka, Toshiki Hirakawa, Satoru Noda, Naoki Aomatsu, Tsuyoshi Hasegawa, Taro Matsuzaki, Tetsuji Sawada, Masaichi Ohira, Kosei Hirakawa

    ANTICANCER RESEARCH   31 ( 10 )   3369 - 3375   2011.10( ISSN:0250-7005

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    Aim: The aim of this study was to examine the effects of hypoxia on radiosensitivity and to analyze the mechanisms responsible for radiation resistance in gastric and esophageal cancer. Materials and Methods: A gastric cancer cell line, OCUM-12, and an esophageal cancer cell line, TE-6, were used. The effects of hypoxia with irradiation on the growth-activity, cell cycle distribution, and gene expression were examined. Results: Both acute and chronic hypoxia decreased radiosensitivity of cancer cells. The radiosensitivity of chronic hypoxic cells was significantly enhanced by reoxygenation. Acute and chronic all hypoxia reduced the percentage of cells in the G(2)/M and S phases, respectively. In acute hypoxia, the mRNA expression of BRCA1 and BRCA2 was reduced in cancer cells. Reoxygenation increased the expression of BRCA1 and BRCA2. Conclusion: Hypoxia is associated with radiation resistance. Therefore, reoxygenation may enhance the radiosensitivity of hypoxic cells. BRCA1 and BRCA2 may be associated with factors for radiation resistance by regulation of cell cycle progression.

    PubMed

  • Effects of acute and chronic hypoxia on the radiosensitivity of gastric and esophageal cancer cells. Reviewed

    Kato Y, Yashiro M, Fuyuhiro Y, Kashiwagi S, Matsuoka J, Hirakawa T, Noda S, Aomatsu N, Hasegawa T, Matsuzaki T, Sawada T, Ohira M, Hirakawa K

    Anticancer research   31 ( 10 )   3369 - 75   2011.10( ISSN:0250-7005

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  • RhoA/ROCK signaling mediates plasticity of scirrhous gastric carcinoma motility Reviewed

    Tasuku Matsuoka, Masakazu Yashiro, Yukihiro Kato, Osamu Shinto, Shinichiro Kashiwagi, Kosei Hirakawa

    CLINICAL & EXPERIMENTAL METASTASIS   28 ( 7 )   627 - 36   2011.10( ISSN:0262-0898

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    The small guanosine triphosphatase (GTPase) Rho and its downstream effector Rho-associated kinase (ROCK) is one of a key mediator involved in controlling focal adhesions and the dynamics of actin stress fibers. The molecular mechanisms for the function of Rho/ROCK pathway leading to the progression in scirrhous gastric carcinoma cells have not been defined. The activation of RhoA in several gastric carcinoma cells was examined. The role of RhoA/ROCK pathway in the metastatic processes of gastric carcinoma cells, using a human scirrhous gastric cancer cell line, OCUM-2MD3 was investigated by in vitro adhesion and invasion assay. The effect of ROCK inhibitor, Y-27632 on the mRNA expression of the integrin family and MMP in gastric carcinoma cells was subsequently examined by Reverse transcriptional (RT)-PCR analysis. Finally, Random OCUM-2MD3 cell motility was evaluated using Time-lapse microscopy. ROCK inhibitor significantly increased the adhesion of OCUM-2MD3 cells to the extracellular matrix (ECM) protein matrigel. Further examination using ECM components showed enhanced binding ability was obtained only in laminin and Integrin subunits alpha 3-integrin was clearly up-regulated by treatment with Y-27632 in OCUM-2MD3 cells. ROCK inhibitor also enhanced the invasion of OCUM-2MD3 cells through matrigel and the expression of membrane-type 1 matrix metalloproteinase (MT1-MMP). Time-lapse microscopy showed conversion of OCUM-2MD3 cells from round to more elongated morphology in the presence of Y-27632, suggesting that inhibition of RhoA/ROCK pathway undergo a so-called &apos;amoeboid to mesenchymal&apos; transition. The fact that Rac1 inhibitor decreased the facilitated invasion by ROCK inhibitor suggested the possibility that increased invasion ability of OCUM-2MD3 cells was related to Rac activity. These data may suggest that RhoA/ROCK regulate plasticity of metastatic gastric carcinoma via mesenchymal-amoeboid transition, leading to provide new insights for designing a new and effective treatment for this type of refractory carcinoma.

    DOI: 10.1007/s10585-011-9396-6

    PubMed

  • THBS4, a novel stromal molecule of diffuse-type gastric adenocarcinomas, identified by transcriptome-wide expression profiling Reviewed

    Susann Foerster, Stephan Gretschel, Thomas Joens, Masakazu Yashiro, Wolfgang Kemmner

    MODERN PATHOLOGY   24 ( 10 )   1390 - 1403   2011.10( ISSN:0893-3952

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    Gastric adenocarcinomas can be divided into two major histological types, the diffuse and intestinal type (Lauren classification). Since they diverge in many clinical and molecular characteristics, it is widely accepted that they represent distinct disease entities that may benefit from different therapeutic approaches. Gene expression profiling studies have identified numerous genes that are differentially expressed between them. However, none of these studies covered the whole transcriptome and the published gene lists reveal little overlap, raising the need for further, more comprehensive analyses. Here, we present the first transcriptome-wide expression profiling study comparing the two types (diffuse n=19, intestinal n=24), which identified &gt;1000 genes that are differentially expressed. Among them, thrombospondin 4 (THBS4) showed the strongest correlation to histological type, with vast overexpression in the diffuse type. Quantitative real-time PCR validated this strong overexpression and revealed that intestinal tumors generally lack THBS4 expression. Immunohistochemistry demonstrated THBS4 overexpression on the protein level (n=10) and localized THBS4 to the stromal aspect. Its expression was primarily observed within the extracellular matrix surrounding the tumor cells, with the highest intensities found in regions of high tumor cell density and invasion. Intestinal tumors and matched non-neoplastic gastric epithelium and stroma did not feature any relevant THBS4 expression in a preliminary selection of analyzed cases (n=5). Immunohistochemical colocalization and in vitro studies revealed that THBS4 is expressed and secreted by cancer-associated fibroblasts. Furthermore, we show that THBS4 transcription in fibroblasts is stimulated by tumor cells. This study is the first to identify THBS4 as a powerful marker for diffuse-type gastric adenocarcinomas and to provide an initial characterization of its expression in the course of this disease. Modern Pathology (2011) 24, 1390-1403; doi:10.1038/modpathol.2011.99; published online 24 June 2011

    DOI: 10.1038/modpathol.2011.99

    PubMed

  • Upregulation of cancer-associated myofibroblasts by TGF-beta from scirrhous gastric carcinoma cells Reviewed

    Fuyuhiro Y., Yashiro M., Noda S., Kashiwagi S., Matsuoka J., Doi Y., Kato Y., Hasegawa T., Sawada T., Hirakawa K.

    BRITISH JOURNAL OF CANCER   105 ( 7 )   996 - 1001   2011.09( ISSN:0007-0920

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    DOI: 10.1038/bjc.2011.330

  • Upregulation of cancer-associated myofibroblasts by TGF-β from scirrhous gastric carcinoma cells. Reviewed

    Fuyuhiro Y, Yashiro M, Noda S, Kashiwagi S, Matsuoka J, Doi Y, Kato Y, Hasegawa T, Sawada T, Hirakawa K

    British journal of cancer   105 ( 7 )   996 - 1001   2011.09( ISSN:0007-0920

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    DOI: 10.1038/bjc.2011.330

    PubMed

  • 進行再発食道癌に対するドセタキセル、ネダプラチン併用外来化学療法の治療成績 Reviewed

    大平 雅一, 久保 尚士, 田中 浩明, 櫻井 克宜, 六車 一哉, 永原 央, 木村 健二郎, 天野 良亮, 野田 英児, 八代 正和, 山田 靖哉, 前田 清, 山下 好人, 澤田 鉄二, 平川 弘聖

    日本癌治療学会誌   46 ( 2 )   591 - 591   2011.09( ISSN:0021-4671

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  • A FGFR2 inhibitor, Ki23057, enhances the chemosensitivity of drug-resistant gastric cancer cells Reviewed

    Qiu Hong, Yashiro Masakazu, Zhang Xiaotian, Miwa Atsushi, Hirakawa Kosei

    CANCER LETTERS   307 ( 1 )   47 - 52   2011.08( ISSN:0304-3835

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    DOI: 10.1016/j.canlet.2011.03.015

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  • A FGFR2 inhibitor, Ki23057, enhances the chemosensitivity of drug-resistant gastric cancer cells Reviewed

    Hong Qiu, Masakazu Yashiro, Xiaotian Zhang, Atsushi Miwa, Kosei Hirakawa

    CANCER LETTERS   307 ( 1 )   47 - 52   2011.08( ISSN:0304-3835

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    Aim: The aim of this study was to clarify the ability of a FGFR2 inhibitor, Ki23057, to enhance the chemosensitivity of drug-resistant gastric cancer cell lines when used in combination with chemotherapeutic drugs.
    Materials and methods: Five cancer cell lines resistant to irinotecan (SN38), paclitaxel (PTX), etoposide (VP16), oxaliplatin (OXA), and gemcitabine (GEM) were respectively established from a parent gastric cancer cell line, OCUM-2M, and were named OCUM-2M/SN38, OCUM-2M/PTX, OCUM-2M/VP16, OCUM-2M/OXA, and OCUM-2M/GEM. The effects of the combination of Ki23057 with anticancer drugs on proliferation, apoptosis, and mRNA expression were examined.
    Results: Ki23057 significantly decreased the IC(50) values of OCUM-2M/SN38, OCUM-2M/PTX, and OCUM-2M/VP16, but not those of OCUM-2M/OXA and OCUM-2M/GEM. Ki23057 significantly enhanced the apoptosis rates induced by chemotherapeutic drugs in both the drug-resistant cell lines and the parental cell line. Ki23057 decreased the ERCC1 expression level in OCUM-2M/SN38, OCUM-2M/PTX, and OCUM-2M/VP16. Ki23057 increased the p53 expression level in OCUM-2M/SN38 and OCUM-2M/PTX, but not in OCUM-2M/VP16.
    Conclusion: The FGFR2 inhibitor Ki23057 might be therapeutically promising for treating drug-resistant gastric cancer cells, especially when used in combination with SN38, PTX, or VP16. The apoptosis process might be the main mechanism underlying the synergistic effect of these combinations. The ERCC1 and p53 genes may play an integral role in the synergism between Ki23057 and chemotherapeutic agents in drug-resistant cell lines. (C) 2011 Elsevier Ireland Ltd. All rights reserved.

    DOI: 10.1016/j.canlet.2011.03.015

    PubMed

  • PS-013-3 スキルス胃癌細胞による樹状細胞の直接的機能抑制(PS-013 ポスターセッション(13)胃:基礎-1,第111回日本外科学会定期学術集会) Reviewed

    岩内 武彦, 田中 浩明, 吉井 真美, 伊藤 厳太郎, 久保 尚士, 六車 一哉, 永原 央, 木村 健二郎, 天野 良亮, 野田 英児, 山田 靖哉, 八代 正和, 前田 清, 澤田 鉄二, 大平 雅一, 平川 弘聖

    一般社団法人日本外科学会 日本外科学会雑誌   112 ( 1 )   2011.05( ISSN:03014894

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  • SY-2-4 膵管内乳頭粘液性腫瘍(IPMN)の亜型分類と悪性度の検討(SY-2 シンポジウム(2)IPMNをめぐる諸問題-診断から治療まで-,第111回日本外科学会定期学術集会) Reviewed

    大平 豪, 山田 靖哉, 天野 良亮, 木村 健二郎, 村田 哲洋, 中本 健太郎, 永原 央, 野田 英児, 久保 尚士, 田中 浩明, 六車 一哉, 高島 勉, 八代 正和, 小野田 尚佳, 前田 清, 澤田 鉄二, 仲田 文造, 大平 雅一, 石川 哲郎, 平川 弘聖

    一般社団法人日本外科学会 日本外科学会雑誌   112 ( 1 )   2011.05( ISSN:03014894

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  • PS-200-7 腹腔鏡下大腸手術におけるエンドラクターの有用性(PS-200 ポスターセッション(200)大腸:手術-9,第111回日本外科学会定期学術集会) Reviewed

    永原 央, 野田 英児, 前田 清, 井上 透, 中本 健太郎, 天野 良亮, 久保 尚士, 田中 浩明, 六車 一哉, 八代 正和, 山田 靖哉, 澤田 鉄二, 仲田 文造, 西口 幸雄, 大平 雅一, 平川 弘聖

    一般社団法人日本外科学会 日本外科学会雑誌   112 ( 1 )   2011.05( ISSN:03014894

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  • PS-162-1 胃癌におけるMHC classI発現の有無と術後補助免疫化学療法の効果(PS-162 ポスターセッション(162)胃:その他-4,第111回日本外科学会定期学術集会) Reviewed

    伊藤 厳太郎, 田中 浩明, 六車 一哉, 吉井 真美, 岩内 武彦, 久保 尚志, 永原 央, 木村 健二郎, 天野 良亮, 野田 英児, 山田 靖哉, 八代 正和, 前田 清, 澤田 鉄二, 大平 雅一, 平川 弘聖

    一般社団法人日本外科学会 日本外科学会雑誌   112 ( 1 )   2011.05( ISSN:03014894

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  • PS-119-6 StageIV胃癌に対する外科的治療介入の意義(PS-119 ポスターセッション(119)胃:集学的治療-1,第111回日本外科学会定期学術集会) Reviewed

    六車 一哉, 田中 浩明, 櫻井 克宣, 李 友浩, 木村 健二郎, 永原 央, 天野 良亮, 野田 英児, 久保 尚士, 八代 正和, 山田 靖哉, 山下 好人, 豊川 貴弘, 山本 篤, 清水 貞利, 前田 清, 澤田 鉄二, 仲田 文造, 大平 雅一, 石川 哲郎, 平川 弘聖

    一般社団法人日本外科学会 日本外科学会雑誌   112 ( 1 )   2011.05( ISSN:03014894

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  • PS-115-7 NAC効果予測マーカーとしての癌細胞E-cadherin発現の有用性(PS-115 ポスターセッション(115)乳腺:基礎-4,第111回日本外科学会定期学術集会) Reviewed

    青松 直撥, 八代 正和, 柏木 伸一郎, 高島 勉, 吉井 真美, 平川 俊基, 松岡 順子, 加藤 幸裕, 冬廣 雄彦, 川尻 成美, 小野田 尚佳, 石川 哲郎, 平川 弘聖

    一般社団法人日本外科学会 日本外科学会雑誌   112 ( 1 )   2011.05( ISSN:03014894

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  • PS-094-7 切除不能遠隔転移を有する大腸癌の原発巣非切除例に対する化学療法(PS-094 ポスターセッション(94)大腸:化学療法-1,第111回日本外科学会定期学術集会) Reviewed

    野田 英児, 前田 清, 永原 央, 井上 透, 中本 健太郎, 天野 良亮, 久保 尚士, 田中 浩明, 六車 一哉, 八代 正和, 山田 靖哉, 澤田 鉄二, 仲田 文造, 高島 勉, 小野田 尚佳, 西口 幸雄, 大平 雅一, 石川 哲郎, 池原 照幸, 平川 弘聖

    一般社団法人日本外科学会 日本外科学会雑誌   112 ( 1 )   2011.05( ISSN:03014894

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  • PS-089-5 胃癌術後におけるPSK併用補助免疫化学療法の効果(PS-089 ポスターセッション(89)胃:化学療法-1,第111回日本外科学会定期学術集会) Reviewed

    田中 浩明, 六車 一哉, 久保 尚士, 澤田 鉄二, 大平 雅一, 木村 健二郎, 永原 央, 天野 良亮, 野田 英児, 山田 靖哉, 八代 正和, 小野田 尚佳, 前田 清, 仲田 文造, 石川 哲郎, 平川 弘聖

    一般社団法人日本外科学会 日本外科学会雑誌   112 ( 1 )   2011.05( ISSN:03014894

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  • PS-053-5 circular staplerを用いた安全かつ簡便な腹腔鏡下食道・空腸吻合術(PS-053 ポスターセッション(53)胃:手術-4,第111回日本外科学会定期学術集会) Reviewed

    櫻井 克宣, 六車 一哉, 永原 央, 天野 良亮, 野田 英児, 久保 尚士, 田中 浩明, 山田 靖哉, 八代 正和, 前田 清, 小野田 尚佳, 澤田 鉄二, 仲田 文造, 大平 雅一, 石川 哲郎, 平川 弘聖

    一般社団法人日本外科学会 日本外科学会雑誌   112 ( 1 )   2011.05( ISSN:03014894

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  • PS-015-5 低酸素環境下におけるスキルス胃癌細胞の上皮間葉転換(EMT)の機序と阻害物質の検討(PS-015 ポスターセッション(15)胃:基礎-3,第111回日本外科学会定期学術集会) Reviewed

    松岡 順子, 八代 正和, 柏木 伸一郎, 加藤 幸裕, 冬廣 雄彦, 木村 健二郎, 永原 央, 天野 良亮, 野田 英児, 久保 尚士, 田中 浩明, 六車 一哉, 山田 靖哉, 前田 清, 澤田 鉄二, 大平 雅一, 石川 哲郎, 平川 弘聖

    一般社団法人日本外科学会 日本外科学会雑誌   112 ( 1 )   2011.05( ISSN:03014894

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  • PS-013-4 制御性T細胞浸潤と胃癌組織型との関係(PS-013 ポスターセッション(13)胃:基礎-1,第111回日本外科学会定期学術集会) Reviewed

    吉井 真美, 田中 浩明, 櫻井 克宣, 永原 央, 木村 健二郎, 天野 良亮, 野田 英児, 久保 尚士, 六車 一哉, 山田 靖哉, 八代 正和, 前田 清, 澤田 鉄二, 大平 雅一, 石川 哲郎, 平川 弘聖

    一般社団法人日本外科学会 日本外科学会雑誌   112 ( 1 )   2011.05( ISSN:03014894

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  • VW-2-1-3 ベットローテーションを利用した半腹臥位胸腔鏡下食道切除術(VW2-1 ビデオワークショップ(2)-1 食道鏡視下手術の工夫,第111回日本外科学会定期学術集会) Reviewed

    久保 尚士, 中村 雅憲, 李 友浩, 櫻井 克宣, 森本 純也, 永原 央, 天野 良亮, 野田 英児, 田中 浩明, 六車 一哉, 高島 勉, 山田 靖哉, 山下 好人, 八代 正和, 仲田 文造, 前田 清, 小野田 尚佳, 澤田 鉄二, 大平 雅一, 石川 哲郎, 平川 弘聖

    一般社団法人日本外科学会 日本外科学会雑誌   112 ( 1 )   2011.05( ISSN:03014894

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  • SF-089-3 トリプルネガティブ乳癌における化学療法感受性マーカーとしてのE-cadherin/Ki67発現(サージカルフォーラム(89)乳腺:化学療法-1,第111回日本外科学会定期学術集会) Reviewed

    柏木 伸一郎, 八代 正和, 高島 勉, 青松 直撥, 川尻 成美, 池田 克実, 小川 佳成, 小野田 尚佳, 石川 哲郎, 平川 弘聖

    一般社団法人日本外科学会 日本外科学会雑誌   112 ( 1 )   2011.05( ISSN:03014894

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  • SF-039-5 胃癌幹細胞様SP細胞の腫瘍形成におけるニッチ線維芽細胞の影響(SF-039 サージカルフォーラム(39)胃:基礎-1,第111回日本外科学会定期学術集会) Reviewed

    長谷川 毅, 八代 正和, 松岡 順子, 冬廣 雄彦, 櫻井 克宣, 木村 健二郎, 永原 央, 野田 英児, 久保 尚士, 田中 浩明, 六車 一哉, 山田 靖哉, 前田 清, 澤田 鉄二, 仲田 文造, 大平 雅一, 石川 哲郎, 平川 弘聖

    一般社団法人日本外科学会 日本外科学会雑誌   112 ( 1 )   2011.05( ISSN:03014894

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  • VW-4-7 尾側膵切除術におけるDuetを用いた膵切離の試み(VW4 ビデオワークショップ(4) 肝胆膵手術-合併症を防ぐ工夫,第111回日本外科学会定期学術集会) Reviewed

    天野 良亮, 山田 靖哉, 大平 豪, 永原 央, 久保 尚士, 田中 浩明, 六車 一哉, 八代 正和, 前田 清, 仲田 文造, 大平 雅一, 石川 哲郎, 平川 弘聖

    一般社団法人日本外科学会 日本外科学会雑誌   112 ( 1 )   2011.05( ISSN:03014894

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  • PS-013-3 スキルス胃癌細胞による樹状細胞の直接的機能抑制(PS-013 ポスターセッション(13)胃:基礎-1,第111回日本外科学会定期学術集会) Reviewed

    岩内 武彦, 田中 浩明, 吉井 真美, 伊藤 厳太郎, 久保 尚士, 六車 一哉, 永原 央, 木村 健二郎, 天野 良亮, 野田 英児, 山田 靖哉, 八代 正和, 前田 清, 澤田 鉄二, 大平 雅一, 平川 弘聖

    日本外科学会雑誌   112 ( 1 )   528   2011.05( ISSN:03014894

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  • VW-4-7 尾側膵切除術におけるDuetを用いた膵切離の試み(VW4 ビデオワークショップ(4) 肝胆膵手術-合併症を防ぐ工夫,第111回日本外科学会定期学術集会) Reviewed

    天野 良亮, 山田 靖哉, 大平 豪, 永原 央, 久保 尚士, 田中 浩明, 六車 一哉, 八代 正和, 前田 清, 仲田 文造, 大平 雅一, 石川 哲郎, 平川 弘聖

    日本外科学会雑誌   112 ( 1 )   313   2011.05( ISSN:03014894

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  • VW-2-1-3 ベットローテーションを利用した半腹臥位胸腔鏡下食道切除術(VW2-1 ビデオワークショップ(2)-1 食道鏡視下手術の工夫,第111回日本外科学会定期学術集会) Reviewed

    久保 尚士, 中村 雅憲, 李 友浩, 櫻井 克宣, 森本 純也, 永原 央, 天野 良亮, 野田 英児, 田中 浩明, 六車 一哉, 高島 勉, 山田 靖哉, 山下 好人, 八代 正和, 仲田 文造, 前田 清, 小野田 尚佳, 澤田 鉄二, 大平 雅一, 石川 哲郎, 平川 弘聖

    日本外科学会雑誌   112 ( 1 )   304   2011.05( ISSN:03014894

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  • SY-2-4 膵管内乳頭粘液性腫瘍(IPMN)の亜型分類と悪性度の検討(SY-2 シンポジウム(2)IPMNをめぐる諸問題-診断から治療まで-,第111回日本外科学会定期学術集会) Reviewed

    大平 豪, 山田 靖哉, 天野 良亮, 木村 健二郎, 村田 哲洋, 中本 健太郎, 永原 央, 野田 英児, 久保 尚士, 田中 浩明, 六車 一哉, 高島 勉, 八代 正和, 小野田 尚佳, 前田 清, 澤田 鉄二, 仲田 文造, 大平 雅一, 石川 哲郎, 平川 弘聖

    日本外科学会雑誌   112 ( 1 )   231   2011.05( ISSN:03014894

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  • SF-089-3 トリプルネガティブ乳癌における化学療法感受性マーカーとしてのE-cadherin/Ki67発現(サージカルフォーラム(89)乳腺:化学療法-1,第111回日本外科学会定期学術集会) Reviewed

    柏木 伸一郎, 八代 正和, 高島 勉, 青松 直撥, 川尻 成美, 池田 克実, 小川 佳成, 小野田 尚佳, 石川 哲郎, 平川 弘聖

    日本外科学会雑誌   112 ( 1 )   447   2011.05( ISSN:03014894

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  • SF-039-5 胃癌幹細胞様SP細胞の腫瘍形成におけるニッチ線維芽細胞の影響(SF-039 サージカルフォーラム(39)胃:基礎-1,第111回日本外科学会定期学術集会) Reviewed

    長谷川 毅, 八代 正和, 松岡 順子, 冬廣 雄彦, 櫻井 克宣, 木村 健二郎, 永原 央, 野田 英児, 久保 尚士, 田中 浩明, 六車 一哉, 山田 靖哉, 前田 清, 澤田 鉄二, 仲田 文造, 大平 雅一, 石川 哲郎, 平川 弘聖

    日本外科学会雑誌   112 ( 1 )   384   2011.05( ISSN:03014894

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  • PS-200-7 腹腔鏡下大腸手術におけるエンドラクターの有用性(PS-200 ポスターセッション(200)大腸:手術-9,第111回日本外科学会定期学術集会) Reviewed

    永原 央, 野田 英児, 前田 清, 井上 透, 中本 健太郎, 天野 良亮, 久保 尚士, 田中 浩明, 六車 一哉, 八代 正和, 山田 靖哉, 澤田 鉄二, 仲田 文造, 西口 幸雄, 大平 雅一, 平川 弘聖

    日本外科学会雑誌   112 ( 1 )   854   2011.05( ISSN:03014894

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  • PS-162-1 胃癌におけるMHC classI発現の有無と術後補助免疫化学療法の効果(PS-162 ポスターセッション(162)胃:その他-4,第111回日本外科学会定期学術集会) Reviewed

    伊藤 厳太郎, 田中 浩明, 六車 一哉, 吉井 真美, 岩内 武彦, 久保 尚志, 永原 央, 木村 健二郎, 天野 良亮, 野田 英児, 山田 靖哉, 八代 正和, 前田 清, 澤田 鉄二, 大平 雅一, 平川 弘聖

    日本外科学会雑誌   112 ( 1 )   786   2011.05( ISSN:03014894

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  • PS-119-6 StageIV胃癌に対する外科的治療介入の意義(PS-119 ポスターセッション(119)胃:集学的治療-1,第111回日本外科学会定期学術集会) Reviewed

    六車 一哉, 田中 浩明, 櫻井 克宣, 李 友浩, 木村 健二郎, 永原 央, 天野 良亮, 野田 英児, 久保 尚士, 八代 正和, 山田 靖哉, 山下 好人, 豊川 貴弘, 山本 篤, 清水 貞利, 前田 清, 澤田 鉄二, 仲田 文造, 大平 雅一, 石川 哲郎, 平川 弘聖

    日本外科学会雑誌   112 ( 1 )   710   2011.05( ISSN:03014894

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  • PS-115-7 NAC効果予測マーカーとしての癌細胞E-cadherin発現の有用性(PS-115 ポスターセッション(115)乳腺:基礎-4,第111回日本外科学会定期学術集会) Reviewed

    青松 直撥, 八代 正和, 柏木 伸一郎, 高島 勉, 吉井 真美, 平川 俊基, 松岡 順子, 加藤 幸裕, 冬廣 雄彦, 川尻 成美, 小野田 尚佳, 石川 哲郎, 平川 弘聖

    日本外科学会雑誌   112 ( 1 )   704   2011.05( ISSN:03014894

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  • PS-094-7 切除不能遠隔転移を有する大腸癌の原発巣非切除例に対する化学療法(PS-094 ポスターセッション(94)大腸:化学療法-1,第111回日本外科学会定期学術集会) Reviewed

    野田 英児, 前田 清, 永原 央, 井上 透, 中本 健太郎, 天野 良亮, 久保 尚士, 田中 浩明, 六車 一哉, 八代 正和, 山田 靖哉, 澤田 鉄二, 仲田 文造, 高島 勉, 小野田 尚佳, 西口 幸雄, 大平 雅一, 石川 哲郎, 池原 照幸, 平川 弘聖

    日本外科学会雑誌   112 ( 1 )   668   2011.05( ISSN:03014894

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  • PS-089-5 胃癌術後におけるPSK併用補助免疫化学療法の効果(PS-089 ポスターセッション(89)胃:化学療法-1,第111回日本外科学会定期学術集会) Reviewed

    田中 浩明, 六車 一哉, 久保 尚士, 澤田 鉄二, 大平 雅一, 木村 健二郎, 永原 央, 天野 良亮, 野田 英児, 山田 靖哉, 八代 正和, 小野田 尚佳, 前田 清, 仲田 文造, 石川 哲郎, 平川 弘聖

    日本外科学会雑誌   112 ( 1 )   659   2011.05( ISSN:03014894

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  • PS-053-5 circular staplerを用いた安全かつ簡便な腹腔鏡下食道・空腸吻合術(PS-053 ポスターセッション(53)胃:手術-4,第111回日本外科学会定期学術集会) Reviewed

    櫻井 克宣, 六車 一哉, 永原 央, 天野 良亮, 野田 英児, 久保 尚士, 田中 浩明, 山田 靖哉, 八代 正和, 前田 清, 小野田 尚佳, 澤田 鉄二, 仲田 文造, 大平 雅一, 石川 哲郎, 平川 弘聖

    日本外科学会雑誌   112 ( 1 )   597   2011.05( ISSN:03014894

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  • PS-015-5 低酸素環境下におけるスキルス胃癌細胞の上皮間葉転換(EMT)の機序と阻害物質の検討(PS-015 ポスターセッション(15)胃:基礎-3,第111回日本外科学会定期学術集会) Reviewed

    松岡 順子, 八代 正和, 柏木 伸一郎, 加藤 幸裕, 冬廣 雄彦, 木村 健二郎, 永原 央, 天野 良亮, 野田 英児, 久保 尚士, 田中 浩明, 六車 一哉, 山田 靖哉, 前田 清, 澤田 鉄二, 大平 雅一, 石川 哲郎, 平川 弘聖

    日本外科学会雑誌   112 ( 1 )   532   2011.05( ISSN:03014894

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  • PS-013-4 制御性T細胞浸潤と胃癌組織型との関係(PS-013 ポスターセッション(13)胃:基礎-1,第111回日本外科学会定期学術集会) Reviewed

    吉井 真美, 田中 浩明, 櫻井 克宣, 永原 央, 木村 健二郎, 天野 良亮, 野田 英児, 久保 尚士, 六車 一哉, 山田 靖哉, 八代 正和, 前田 清, 澤田 鉄二, 大平 雅一, 石川 哲郎, 平川 弘聖

    日本外科学会雑誌   112 ( 1 )   528   2011.05( ISSN:03014894

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  • Is E-cadherin a useful surrogate marker to predict chemosensitivity of chemotherapy for triple-negative breast cancer? Reviewed

    Kashiwagi S., Yashiro M., Takashima T., Aomatsu N., Kawajiri H., Onoda N., Nakata B., Ishikawa T., Hirakawa K.

    JOURNAL OF CLINICAL ONCOLOGY   29 ( 15 )   2011.05( ISSN:0732-183X

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  • 原発巣切除後10年以上経過して左腸腰筋内再発を認めた食道gastrointestinal stromal tumorの1例 Reviewed

    森本 純也, 大平 雅一, 久保 尚士, 田中 浩明, 六車 一哉, 八代 正和, 澤田 鉄二, 大澤 政彦, 山下 好人, 平川 弘聖

    日本消化器外科学会雑誌   44 ( 5 )   519 - 525   2011.05( ISSN:0386-9768

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    食道gastrointestinal stromal tumor(以下,GISTと略記)は消化管GISTの約2%と比較的まれな疾患である.症例は52歳の男性で,平成8年12月上旬より嚥下困難感,心窩部痛,背部痛を自覚し近医受診し,精査にて胸部中部食道に2型の腫瘍を認め当科紹介となった.平成9年2月に根治術を施行し,病理組織学的診断は平滑筋肉腫であった.術後11年10ヵ月目に左腰背部痛を自覚し,精査にて左腸腰筋内腫瘍を認め,平成21年3月に摘出術を施行した.病理組織学的診断はc-kit+,CD34+,desmin-,αSMA-,S-100-でありGISTと診断し,また,食道腫瘍を再度病理組織学的検査を施行したところ,同様の結果であり,今回の左腸腰筋内腫瘍は食道GISTの再発と診断された.術後経過良好で現在,外来にてメシル酸イマチニブ400mg/dayの補助化学療法を開始し経過観察中である.(著者抄録)

  • c-Kit / CD117 is a predictive prognostic marker for patients with basal-like breast cancer Reviewed

    Kashiwagi Shinichiro, Yashiro Masakazu, Takashima Tsutomu, Aomatsu Naoki, Kawajiri Hidemi, Tanaka Hiroaki, Onoda Naoyoshi, Nakata Bunzo, Ishikawa Tetsuro, Hirakawa Kosei

    CANCER RESEARCH   71   2011.04( ISSN:0008-5472

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    DOI: 10.1158/1538-7445.AM2011-3136

  • Clinical significance of HER3 expression in curatively resected pancreatic cancer Reviewed

    Hirakawa Toshiki, Nakata Bunzo, Kashiwagi Shinichiro, Kato Yukihiro, Fuyuhiro Yuhiko, Iwauchi Takehiko, Matsusoka Junko, Itoh Gentaro, Aomatsu Naoki, Yoshii Mami, Hasegawa Tsuyoshi, Amano Ryosuke, Kubo Naoshi, Tanaka Hiroaki, Muguruma Kazuya, Yamada Nobuya, Yashiro Masakazu, Sawada Tetsuji, Ohira Masaichi, Hirakawa Kosei

    CANCER RESEARCH   71   2011.04( ISSN:0008-5472

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    DOI: 10.1158/1538-7445.AM2011-2265

  • The impact of adjuvant immunochemotherapy using protein-bound polysaccharide-K on overall survival of gastric cancer Reviewed

    Tanaka Hiroaki, Ohira Masaichi, Muguruma Kazuya, Kubo Naoshi, Nagahara Hsashi, Kimura Kenjiro, Amano Ryosuke, Noda Eiji, Yamada Nobuya, Yashiro Masakazu, Maeda Kiyoshi, Onoda Naoyoshi, Sawada Tetsuji, Nakata Bunzo, Ishikawa Tetsuro, Hirakawa Kosei

    CANCER RESEARCH   71   2011.04( ISSN:0008-5472

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    DOI: 10.1158/1538-7445.AM2011-1796

  • The effect of synergic anti-proliferation of DNA methyltransferase inhibitor binding to anti-cancer drugs in gastric cancer Reviewed

    Muguruma Kazuya, Yashiro Masakazu, Tanaka Hiroaki, Kimura Kenjirou, Nagahara Hisashi, Amano Ryousuke, Noda Eiji, Kubo Naoshi, Yamada Nobuya, Maeda Kiyoshi, Ohira Masaichi, Ishikawa Tetsurou, Hirakawa Kosei

    CANCER RESEARCH   71   2011.04( ISSN:0008-5472

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    DOI: 10.1158/1538-7445.AM2011-100

  • Synergistic antitumor effects of FGFR2 inhibitor with 5-fluorouracil on diffuse-type gastric carcinoma Reviewed

    Yashiro Masakazu, Shinto Osamu, Nakamura Kazunori, Tendo Masashige, Matsuoka Tasuku, Matsuzaki Taro, Kaizaki Ryoji, Miwa Atsushi, Hirakawa Kosei

    CANCER RESEARCH   71   2011.04( ISSN:0008-5472

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    DOI: 10.1158/1538-7445.AM2011-2552

  • Impact of histological types on infiltration of regulatory T cells in gastric cancer Reviewed

    Yoshii Mami, Tanaka Hiroaki, Sakurai Katsunobu, Nagahara Hisashi, Kimura Kenjirou, Amano Ryousuke, Noda Eiji, Kubo Naoshi, Muguruma Kazuya, Yamada Nobuya, Yashiro Masakazu, Maeda Kiyoshi, Sawada Tetsuji, Ohira Masaichi, Ishikawa Tetsurou, Hirakawa Kosei

    CANCER RESEARCH   71   2011.04( ISSN:0008-5472

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    DOI: 10.1158/1538-7445.AM2011-796

  • Effect of cancer-associated fibroblast on the progression of gastric cancer stem cells Reviewed

    Hasegawa Tsuyoshi, Yashiro Masakazu, Matsuoka Junko, Kashiwagi Shinichiro, Fuyuhiro Yuhiko, Sakurai Katsunobu, Sakurai Katsunobu, Kubo Naoshi, Tanaka Hiroaki, Muguruma Kazuya, Yamada Nobuya, Yamada Nobuya, Maeda Kiyoshi, Ohira Masaichi, Ishikawa Tetsuro, Hirakawa Kosei

    CANCER RESEARCH   71   2011.04( ISSN:0008-5472

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    DOI: 10.1158/1538-7445.AM2011-5200

  • E-cadherin is a useful surrogate maker to predict chemosensitivity of neoadjuvant chemotherapy for breast cancer Reviewed

    Aomatsu Naoki, Yashiro Masakazu, Kashiwagi Shinichiro, Takashima Tsutomu, Kawajiri Hidemi, Onoda Naoyoshi, Ishikawa Tetsuro, Hirakawa Kosei

    CANCER RESEARCH   71   2011.04( ISSN:0008-5472

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    DOI: 10.1158/1538-7445.AM2011-3137

  • Direct inhibitory effects of gastric cancer against dendritic cells Reviewed

    Iwauchi Takehiko, Tanaka Hiroaki, Yoshii Mami, Ito Gentaro, Kimura Kenjiro, Nagahara Hisashi, Noda Eiji, Amano Ryosuke, Kubo Naoshi, Muguruma Kazuya, Yamada Nobuya, Yashiro Masakazu, Maeda Kiyoshi, Ohira Masaichi, Hirakawa Kosei

    CANCER RESEARCH   71   2011.04( ISSN:0008-5472

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    DOI: 10.1158/1538-7445.AM2011-793

  • c-Kit / CD117 is a predictive prognostic marker for patients with basal-like breast cancer Reviewed

    Kashiwagi Shinichiro, Yashiro Masakazu, Takashima Tsutomu, Aomatsu Naoki, Kawajiri Hidemi, Tanaka Hiroaki, Onoda Naoyoshi, Nakata Bunzo, Ishikawa Tetsuro, Hirakawa Kosei

    CANCER RESEARCH   71   2011.04( ISSN:0008-5472

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    DOI: 10.1158/1538-7445.AM2011-3136

  • The impact of adjuvant immunochemotherapy using protein-bound polysaccharide-K on overall survival of gastric cancer Reviewed

    Tanaka Hiroaki, Ohira Masaichi, Muguruma Kazuya, Kubo Naoshi, Nagahara Hsashi, Kimura Kenjiro, Amano Ryosuke, Noda Eiji, Yamada Nobuya, Yashiro Masakazu, Maeda Kiyoshi, Onoda Naoyoshi, Sawada Tetsuji, Nakata Bunzo, Ishikawa Tetsuro, Hirakawa Kosei

    CANCER RESEARCH   71   2011.04( ISSN:0008-5472

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    DOI: 10.1158/1538-7445.AM2011-1796

  • Immunopotentiator, protein-bound polysaccharide K, is efficient for advanced gastric cancer with negative expression of MHC Class I Reviewed

    Gentaro Ito, Hiroaki Tanaka, Mami Yoshi, Takehiro Iwauchi, Kazuya Muguruma, Kubo Naoshi, Hisashi Nagahara, Kenjiro Kimura, Ryosuke Amano, Eiji Noda, Nobuya Yamada, Masakazu Yashiro, Naoyoshi Onoda, Kiyoshi Maeda, Bunzo Nakata, Masaichi Ohira, Tetsuro Ishikawa, Kosei Hirakawa

    CANCER RESEARCH   71   2011.04( ISSN:0008-5472

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    DOI: 10.1158/1538-7445.AM2011-2687

  • E-cadherin is a useful surrogate maker to predict chemosensitivity of neoadjuvant chemotherapy for breast cancer Reviewed

    Aomatsu Naoki, Yashiro Masakazu, Kashiwagi Shinichiro, Takashima Tsutomu, Kawajiri Hidemi, Onoda Naoyoshi, Ishikawa Tetsuro, Hirakawa Kosei

    CANCER RESEARCH   71   2011.04( ISSN:0008-5472

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    DOI: 10.1158/1538-7445.AM2011-3137

  • Identification of HLA-A^*2402-restricted epitope peptide derived from ERas oncogene expressed in human scirrhous gastric cancer Reviewed

    IWAUCHI Takehiko, TANAKA Hiroaki, YAMAZOE Sadaaki, YASHIRO Masakazu, YOSHII Mami, KUBO Naoshi, MUGURUMA Kazuya, SAWADA Tetsuji, OHIRA Masaichi, HIRAKAWA Kosei

    Cancer science   102 ( 4 )   683 - 689   2011.04( ISSN:13479032

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  • Identification of HLA-A^*2402-restricted epitope peptide derived from ERas oncogene expressed in human scirrhous gastric cancer Reviewed

    IWAUCHI Takehiko, TANAKA Hiroaki, YAMAZOE Sadaaki, YASHIRO Masakazu, YOSHII Mami, KUBO Naoshi, MUGURUMA Kazuya, SAWADA Tetsuji, OHIRA Masaichi, HIRAKAWA Kosei

    102 ( 4 )   683 - 689   2011.04( ISSN:13479032

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  • Identification of HLA-A*2402-restricted epitope peptide derived from ERas oncogene expressed in human scirrhous gastric cancer Reviewed

    Iwauchi Takehiko, Tanaka Hiroaki, Yamazoe Sadaaki, Yashiro Masakazu, Yoshii Mami, Kubo Naoshi, Muguruma Kazuya, Sawada Tetsuji, Ohira Masaichi, Hirakawa Kosei

    CANCER SCIENCE   102 ( 4 )   683 - 689   2011.04( ISSN:1347-9032

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    DOI: 10.1111/j.1349-7006.2010.01843.x

    PubMed

  • Transforming growth factor-beta decreases the cancer-initiating cell population within diffuse-type gastric carcinoma cells Reviewed

    Ehata S., Johansson E., Katayama R., Koike S., Watanabe A., Hoshino Y., Katsuno Y., Komuro A., Koinuma D., Kano M. R., Yashiro M., Hirakawa K., Aburatani H., Fujita N., Miyazono K.

    ONCOGENE   30 ( 14 )   1693 - 1705   2011.04( ISSN:0950-9232

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    DOI: 10.1038/onc.2010.546

  • Intraperitoneal administration of an adenovirus vector carrying REIC/Dkk-3 suppresses peritoneal dissemination of scirrhous gastric carcinoma Reviewed

    Than Swe Swe, Kataoka Ken, Sakaguchi Masakiyo, Murata Hitoshi, Abarzua Fernando, Taketa Chika, Du Gang, Yashiro Masakazu, Yanagihara Kazuyoshi, Nasu Yasutomo, Kumon Hiromi, Huh Nam-Ho

    ONCOLOGY REPORTS   25 ( 4 )   989 - 995   2011.04( ISSN:1021-335X

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    DOI: 10.3892/or.2011.1149

    PubMed

  • Identification of HLA-A*2402-restricted epitope peptide derived from ERas oncogene expressed in human scirrhous gastric cancer Reviewed

    Takehiko Iwauchi, Hiroaki Tanaka, Sadaaki Yamazoe, Masakazu Yashiro, Mami Yoshii, Naoshi Kubo, Kazuya Muguruma, Tetsuji Sawada, Masaichi Ohira, Kosei Hirakawa

    CANCER SCIENCE   102 ( 4 )   683 - 9   2011.04( ISSN:1347-9032 ( eISSN:1349-7006

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    ERas is a recently identified oncogene involved in the tumorgenic growth of embryonic stem cells. We examined the significance of ERas expression in scirrhous gastric carcinoma, and the possibility of ERas as a tumor-associated antigen of gastric cancer for developing a cancer vaccine. ERas expression was determined in scirrhous gastric carcinoma specimens by immunohistochemical staining. To assess the possibility of the ERas protein as an anticancer vaccine target, we examined whether ERas for HLA-A-restricted epitope peptides were capable of eliciting cytotoxic T lymphocyte activity. Immunohistochemical analysis identified ERas protein in the nucleus and cytoplasm of cancer cells, yet ERas was not expressed in normal gastric epithelium. By western blotting, lysates of the scirrhous gastric cancer cell lines, OCUM-8, OCUM-2MD3 and OCUM-2M were shown to contain a 25-kDa band of ERas protein. ERas mRNA was detected in these cell lines by RT-PCR. To investigate cytotoxicity, we successfully established cytotoxic T lymphocyte clones stimulated by HLA-A*2402-restricted ERas peptides (FALDDPSSL). These peptides have specific cytotoxicity against corresponding HLA-A*2402-positive target cells pulsed with the candidate peptide. We found that the cytotoxic T lymphocyte clones demonstrated cytotoxic activity against OCUM-8 cells that endogenously express ERas. Our results suggest that ERas is a novel tumor-associated antigen with the potential application to be a vaccine against scirrhous gastric cancer. (Cancer Sci 2011; 102: 683-689)

    DOI: 10.1111/j.1349-7006.2010.01843.x

    PubMed

  • Intraperitoneal administration of an adenovirus vector carrying REIC/Dkk-3 suppresses peritoneal dissemination of scirrhous gastric carcinoma Reviewed

    Swe Swe Than, Ken Kataoka, Masakiyo Sakaguchi, Hitoshi Murata, Fernando Abarzua, Chika Taketa, Gang Du, Masakazu Yashiro, Kazuyoshi Yanagihara, Yasutomo Nasu, Hiromi Kumon, Nam-Ho Huh

    ONCOLOGY REPORTS   25 ( 4 )   989 - 995   2011.04( ISSN:1021-335X

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    Expression levels of the novel tumor suppressor gene REIC/Dkk-3 are reduced in many human cancers. We have previously showed that an adenovirus vector carrying REIC/Dkk-3 (Ad-REIC) induced apoptosis of cancer cells selectively and exerted bystander antitumor effects via ER stress. We examined possible effects of Ad-REIC in a peritoneal dissemination model of scirrhous gastric carcinoma (SGC). Among various types of gastric cancer, SGC continues to be associated with the worst prognosis due to a high incidence of metastases in the peritoneal cavity. We found that a single intraperitoneal injection of Ad-REIC suppressed tumor dissemination and disease progression. Immunomodulation by Ad-REIC led to recruitment of natural killer cells inside tumor nodules. We conclude that Ad-REIC gene therapy may be a potential tool in combinatorial approaches to achieve curative effects in SGC.

    DOI: 10.3892/or.2011.1149

    PubMed

  • ヒトスキルス胃癌に発現するERas癌遺伝子由来HLA-A*2402拘束性エピトープペプチドの同定(Identification of HLA-A*2402-restricted epitope peptide derived from ERas oncogene expressed in human scirrhous gastric cancer) Reviewed

    Iwauchi Takehiko, Tanaka Hiroaki, Yamazoe Sadaaki, Yashiro Masakazu, Yoshii Mami, Kubo Naoshi, Muguruma Kazuya, Sawada Tetsuji, Ohira Masaichi, Hirakawa Kosei

    Cancer Science   102 ( 4 )   683 - 689   2011.04( ISSN:1347-9032

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    スキルス胃癌標本におけるERas発現を免疫組織化学染色により検出した。ERas蛋白は癌細胞の核および細胞質で同定されたが、正常胃上皮には発現しなかった。ウエスタンブロット解析により癌細胞株のライセートにERas蛋白の25-kDaバンドが検出された。RT-PCRにより癌細胞株にERas mRNAが検出された。HLA-A*2402拘束性ERasペプチド(FALDDPSSL)により刺激される細胞傷害性Tリンパ球クローンを樹立した。これらのペプチドは、候補ペプチドでパルス処理した対応するHLA-A*2402陽性標的細胞に対して特異的な細胞毒性を示した。細胞傷害性Tリンパ球クローンは内因性にERasを発現するOCUM-8細胞に細胞毒性を示した。ERasはスキルス胃癌に対するワクチンに応用可能な新規の癌関連抗原である。

  • Advantages of adjuvant chemotherapy for patients with triple-negative breast cancer at Stage II: usefulness of prognostic markers E-cadherin and Ki67 Reviewed

    Kashiwagi Shinichiro, Yashiro Masakazu, Takashima Tsutomu, Aomatsu Naoki, Ikeda Katsumi, Ogawa Yoshinari, Ishikawa Tetsuro, Hirakawa Kosei

    BREAST CANCER RESEARCH   13 ( 6 )   R122   2011( ISSN:1465-542X

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    DOI: 10.1186/bcr3068

    PubMed

  • E-cadherin and Ki67 are Predictive Markers for Chemosensitivity in Triple-negative Breast Cancer Reviewed

    Kashiwagi Shinichiro, Yashiro Masakazu, Takashima Tsutomu, Kawajiri Hidemi, Ikeda Katsumi, Ogawa Yoshinari, Onoda Naoyoshi, Ishikawa Tetsuro, Hirakawa Kosei

    Japanese Society for Molecular Tumor Marker Research, Japan Journal of Molecular Tumor Marker Research   ( 26 )   55 - 56   2011

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    DOI: 10.11241/jsmtmr.26.55

    CiNii Article

  • A Case of Reccurence of Esophageal Gastrointestinal Stromal Tumor in the Left Iliopsoas Muscle 11 Years and 10 Months after Esophagectomy Reviewed

    Morimoto Junya, Hirakawa Kosei, Ohira Masaichi, Kubo Naoshi, Tanaka Hiroaki, Muguruma Kazuya, Yashiro Masakazu, Sawada Tetsuji, Osawa Masahiko, Yamashita Yoshito

    The Japanese Society of Gastroenterological Surgery, The Japanese Journal of Gastroenterological Surgery   44 ( 5 )   519 - 525   2011( ISSN:0386-9768

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    Esophageal gastrointestinal stromal tumor (GIST) is rare, accounting for less than 2% of all GISTs. We report a case of esophageal GIST recurrence in the left iliopsoas muscle 11 years and 10 months after esophagectomy. A 52-year-old man referred for dysphagia, epigastralgia, and back pain was found on endoscopic examination to have a huge protruding type 2 tumor in the mid- to lower thoracic esophagus. Esophagectomy with gastric roll reconstruction was performed in February 1997. The histologic diagnosis was leiomyosarcoma. The postoperative course was uneventful. Eleven years and 10 months after esophagectomy, the man reported left back pain. An irregular homogeneous tumor in the left iliopsoas muscle was detected by detailed examinations. The left iliopsoas muscle was resected with the tumor in March 2009. Immunohistopathological examination showed the tumor to be positive for c-kit and CD34, yielding a diagnosis of GIST metastasis. The esophageal tumor resected 11 years and 10 months earlier was reexamined immunohistochemically and diagnosed as esophageal GIST. Thus the final diagnosis of esophageal was GIST metastasis. The postoperative course has been excellent, and adjuvant chemotherapy with imatinib mesylate (400mg/day) was begun in the outpatient clinic where the patient is being followed up.

    DOI: 10.5833/jjgs.44.519

    CiNii Article

  • E-cadherin and Ki67 are Predictive Markers for Chemosensitivity in Triple-negative Breast Cancer Reviewed

    Kashiwagi Shinichiro, Yashiro Masakazu, Takashima Tsutomu, Kawajiri Hidemi, Ikeda Katsumi, Ogawa Yoshinari, Onoda Naoyoshi, Ishikawa Tetsuro, Hirakawa Kosei

    Japan Journal of Molecular Tumor Marker Research   26   55 - 56   2011( eISSN:24338575

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    DOI: 10.11241/jsmtmr.26.55

    CiNii Article

  • Advantages of adjuvant chemotherapy for patients with triple-negative breast cancer at Stage II: Usefulness of prognostic markers E-cadherin and Ki67 Reviewed

    Shinichiro Kashiwagi, Masakazu Yashiro, Tsutomu Takashima, Naoki Aomatsu, Katsumi Ikeda, Yoshinari Ogawa, Tetsuro Ishikawa, Kosei Hirakawa

    Breast Cancer Research   13 ( 6 )   R122   2011( ISSN:1465-5411

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    Introduction: Triple-negative breast cancer (TNBC), which is characterized by negativity for estrogen receptor, progesterone receptor and human epidermal growth factor receptor 2 (HER2), is a high risk breast cancer that lacks specific targets for treatment selection. Chemotherapy is, therefore, the primary systemic modality used in the treatment of this disease, but reliable parameters to predict the chemosensitivity of TNBC have not been clinically available.Methods: A total of 190 TNBC patients who had undergone a curative resection of a primary breast cancer were enrolled. The adjuvant chemotherapy was performed for 138 (73%) of 190 TNBC cases
    60 cases had an anthracyclin-based regimen and 78 a 5-fluorouracil-based regimen. The prognostic value of E-cadherin, Ki67 and p53 expression in the outcome of TNBC patients with adjuvant chemotherapy was evaluated by immunohistochemistry.Results: The adjuvant therapy group, especially those with Stage II TNBC, had a more favorable prognosis than the surgery only group (P = 0.0043), while there was no significant difference in prognosis between the anthracyclin-based regimen and 5-fluorouracil-based regimen. Patients with E-cadherin-negative and Ki67-positive expression showed significantly worse overall survival time than those with either E-cadherin-positive or Ki67-negative expression (P &lt
    0.001). Multivariate analysis showed that the combination of E-cadherin-negative and Ki67-positive expression was strongly predictive of poor overall survival (P = 0.004) in TNBC patients receiving adjuvant chemotherapy. In contrast, p53 status was not a specific prognostic factor.Conclusions: Adjuvant therapy is beneficial for Stage II TNBC patients. The combination of E-cadherin and Ki67 status might be a useful prognostic marker indicating the need for adjuvant chemotherapy in Stage II TNBC patients. © 2011 Kashiwagi et al.
    licensee BioMed Central Ltd.

    DOI: 10.1186/bcr3068

    PubMed

  • A Case of Reccurence of Esophageal Gastrointestinal Stromal Tumor in the Left Iliopsoas Muscle 11 Years and 10 Months after Esophagectomy

    Morimoto Junya, Ohira Masaichi, Kubo Naoshi, Tanaka Hiroaki, Muguruma Kazuya, Yashiro Masakazu, Sawada Tetsuji, Osawa Masahiko, Yamashita Yoshito, Hirakawa Kosei

    The Japanese Journal of Gastroenterological Surgery   44 ( 5 )   519 - 525   2011( ISSN:03869768 ( eISSN:13489372

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    Publishing type:Research paper (scientific journal)  

    Esophageal gastrointestinal stromal tumor (GIST) is rare, accounting for less than 2% of all GISTs. We report a case of esophageal GIST recurrence in the left iliopsoas muscle 11 years and 10 months after esophagectomy. A 52-year-old man referred for dysphagia, epigastralgia, and back pain was found on endoscopic examination to have a huge protruding type 2 tumor in the mid- to lower thoracic esophagus. Esophagectomy with gastric roll reconstruction was performed in February 1997. The histologic diagnosis was leiomyosarcoma. The postoperative course was uneventful. Eleven years and 10 months after esophagectomy, the man reported left back pain. An irregular homogeneous tumor in the left iliopsoas muscle was detected by detailed examinations. The left iliopsoas muscle was resected with the tumor in March 2009. Immunohistopathological examination showed the tumor to be positive for c-kit and CD34, yielding a diagnosis of GIST metastasis. The esophageal tumor resected 11 years and 10 months earlier was reexamined immunohistochemically and diagnosed as esophageal GIST. Thus the final diagnosis of esophageal was GIST metastasis. The postoperative course has been excellent, and adjuvant chemotherapy with imatinib mesylate (400mg/day) was begun in the outpatient clinic where the patient is being followed up.

    DOI: 10.5833/jjgs.44.519

    CiNii Article

  • Transforming growth factor-Β decreases the cancer-initiating cell population within diffuse-type gastric carcinoma cells Reviewed

    Ehata S, Johansson E, Katayama R, Koike S, Watanabe A, Hoshino Y, Katsuno Y, Komuro A, Koinuma D, Kano M.R, Yashiro M, Hirakawa K, Aburatani H, Fujita N, Miyazono K

    Oncogene   30 ( 14 )   1693 - 1705   2011

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    DOI: 10.1038/onc.2010.546

    Other URL: http://orcid.org/0000-0001-7394-895X

  • Monoclonal Antibodies to Fibroblast Growth Factor Receptor 2 Effectively Inhibit Growth of Gastric Tumor Xenografts Reviewed

    Zhao Wei-meng, Wang Lihong, Park Hangil, Chhim Sophea, Tanphanich Melanie, Yashiro Masakazu, Kim K. Jin

    CLINICAL CANCER RESEARCH   16 ( 23 )   5750 - 5758   2010.12( ISSN:1078-0432

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    DOI: 10.1158/1078-0432.CCR-10-0531

    PubMed

  • Clinical Significance of Vimentin-positive Gastric Cancer Cells Reviewed

    Fuyuhiro Yuhiko, Yashiro Masakazu, Noda Satoru, Kashiwagi Shinichiro, Matsuoka Junko, Doi Yosuke, Kato Yukihiro, Kubo Naoshi, Ohira Masaichi, Hirakawa Kosei

    ANTICANCER RESEARCH   30 ( 12 )   5239 - 5243   2010.12( ISSN:0250-7005

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  • Transforming growth factor beta signaling inhibitor, SB-431542, induces maturation of dendritic cells and enhances anti-tumor activity Reviewed

    Tanaka Hiroaki, Shinto Osamu, Yashiro Masakazu, Yamazoe Sadaaki, Iwauchi Takehiko, Muguruma Kazuya, Kubo Naoshi, Ohira Masaichi, Hirakawa Kosei

    ONCOLOGY REPORTS   24 ( 6 )   1637 - 1643   2010.12( ISSN:1021-335X

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    DOI: 10.3892/or_00001028

    PubMed

  • Clinical significance of vimentin-positive gastric cancer cells. Reviewed

    Fuyuhiro Y, Yashiro M, Noda S, Kashiwagi S, Matsuoka J, Doi Y, Kato Y, Kubo N, Ohira M, Hirakawa K

    Anticancer research   30 ( 12 )   5239 - 43   2010.12( ISSN:0250-7005

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    PubMed

  • Monoclonal Antibodies to Fibroblast Growth Factor Receptor 2 Effectively Inhibit Growth of Gastric Tumor Xenografts Reviewed

    Wei-meng Zhao, Lihong Wang, Hangil Park, Sophea Chhim, Melanie Tanphanich, Masakazu Yashiro, K. Jin Kim

    CLINICAL CANCER RESEARCH   16 ( 23 )   5750 - 5758   2010.12( ISSN:1078-0432

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    Purpose: Overexpression of fibroblast growth factor receptor 2 (FGFR2) may be a causative factor of a number of human tumors, especially gastric tumors of the poorly differentiated type. We investigated whether monoclonal antibodies (mAbs) directed against FGFR2 can inhibit the growth of tumors in xenograft models.
    Experimental Design: We generated and characterized 3 mAbs that recognize different epitopes on FGFR2: GAL-FR21, GAL-FR22, and GAL-FR23. The ability of the mAbs to recognize the FGFR2IIIb and FGFR2IIIc isoforms of FGFR2 was determined, as was their ability to block binding of FGF ligands to FGFR2. The capability of the mAbs to inhibit FGF-induced FGFR2 phosphorylation and to downmodulate FGFR2 expression was also investigated. Finally, the ability of the anti-FGFR2 mAbs to inhibit tumor growth was determined by establishing xenografts of SNU-16 and OCUM-2M human gastric tumor cell lines in nude mice, treating with each mAb (0.5-5 mg/kg intraperitoneally twice weekly) and monitoring tumor size.
    Results: Of the 3 mAbs, GAL-FR21 binds only the FGFR2IIIb isoform, whereas GAL-FR22 and GAL-FR23 bind to both the FGFR2IIIb and FGFR2IIIc forms, with binding regions respectively in the D3, D2-D3, and D1 domains of FGFR2. GAL-FR21 and GAL-FR22 blocked the binding of FGF2, FGF7 and FGF10 to FGFR2IIIb. GAL-FR21 inhibited FGF2 and FGF7 induced phosphorylation of FGFR2, and both mAbs downmodulated FGFR2 expression on SNU-16 cells. These mAbs effectively inhibited growth of established SNU-16 and OCUM-2M xenografts in mice.
    Conclusions: Anti-FGFR2 mAbs GAL-FR21 and GAL-FR22 have potential for the treatment of gastric and other tumors. Clin Cancer Res; 16(23); 5750-58. (C)2010 AACR.

    DOI: 10.1158/1078-0432.CCR-10-0531

    PubMed

  • Cancer-stromal interactions in scirrhous gastric carcinoma Reviewed

    Masakazu Yashiro, Kosei Hirakawa

    Cancer Microenvironment   3 ( 1 )   127 - 135   2010.12( ISSN:1875-2292

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    Fibroblasts play an important role in the progression, growth and spread of gastric cancers. Cancer-stroma interactions have been especially evident in the scirrhous type of gastric carcinoma. Fibroblasts are associated with the cancer progression at the primary and metastatic site. The proliferative and invasive ability of scirrhous gastric cancer cells are closely associated with the growth factors produced by organ-specific fibroblasts. Fibroblasts are therefore a key determinant in the malignant progression of gastric cancer and represent an important target for cancer therapies. © 2010 Springer Science+Business Media B.V.

    DOI: 10.1007/s12307-010-0036-5

    PubMed

  • Transforming growth factor beta signaling inhibitor, SB-431542, induces maturation of dendritic cells and enhances anti-tumor activity Reviewed

    Hiroaki Tanaka, Osamu Shinto, Masakazu Yashiro, Sadaaki Yamazoe, Takehiko Iwauchi, Kazuya Muguruma, Naoshi Kubo, Masaichi Ohira, Kosei Hirakawa

    ONCOLOGY REPORTS   24 ( 6 )   1637 - 43   2010.12( ISSN:1021-335X

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    The transforming growth factor beta (TGF beta) stimulates tumor progression and metastasis. Secretion of TGF beta by tumor cells also suppresses an antitumor immune response in which dendritic cells (DCs) play an important role to activate cytotoxic T lymphocytes (CTLs). Herein we report that the small molecule TGF beta signaling inhibitor SB-431542, induces DC maturation in vitro and triggers antitumor activity in vivo. We added SB-431542 to cultures of murine bone-marrow derived DCs (BM-DCs) derived from BALB/c mice and human DCs generated from peripheral monocytes (human DCs) at different concentrations in triplicates and examined expression of co-stimulatory molecules by FACS and production of Interleukin-12 (IL-12) by ELISA. SB induced phenotypic maturation of BM-DCs and human DCs and improved their abilities to produce IL-12 in a dose-dependent manner. SB-431542 also augmented capacity of murine and human DCs to activate naive T cells in allogeneic mixed lymphocyte reaction. Interestingly, SB-431542 augmented the capacity of BM-DCs and human DCs to incorporate FITC-conjugated dextran. Intraperitoneal administration of SB-431542 intiated 3 and 7 days after the implantation of colon-26 cancer cells into the peritoneal cavity of BALB/c mice significantly induced CTL activity against colon-26. We incubated human DCs with SB-431542 and cell lysate of scirrhous gastric cancer cell line OCUM-8, and then examined CTL activities against OCUM-8. CD8 T cells activated by human DCs treated with SB-431542 showed modest augmentation CTL activity against cancer cells. Furthermore, pretreatment of human DCs with SB-431542 upregulated cytotoxic activity against K562 cells, suggesting SB should have potential to activate DCs to natural killer cells. In conclusion, TGF beta receptor I kinase inhibitor such as SB-431542 might induce anti-tumor immune response in immuno-tolerant patients associated with TGF beta activity.

    DOI: 10.3892/or_00001028

    PubMed

  • Clinical significance of vimentin-positive gastric cancer cells. Reviewed

    Fuyuhiro Y, Yashiro M, Noda S, Kashiwagi S, Matsuoka J, Doi Y, Kato Y, Kubo N, Ohira M, Hirakawa K

    Anticancer research   30 ( 12 )   5239 - 43   2010.12( ISSN:0250-7005

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    PubMed

  • Clinical Significance of Vimentin-positive Gastric Cancer Cells Reviewed

    Yuhiko Fuyuhiro, Masakazu Yashiro, Satoru Noda, Shinichiro Kashiwagi, Junko Matsuoka, Yosuke Doi, Yukihiro Kato, Naoshi Kubo, Masaichi Ohira, Kosei Hirakawa

    ANTICANCER RESEARCH   30 ( 12 )   5239 - 5243   2010.12( ISSN:0250-7005

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    Background/Aim: Vimentin expression in epithelial cells is reported to be associated with the malignant phenotype of cancer cells in vitro. However, the clinical significance of vimentin expression in carcinomas is not well understood. The aim of this study was to clarify the significance of vimentin-positive gastric cancer (GC). Patients and Methods: A total of 265 GCs were examined by immunofluorescent staining with antibodies against vimentin and carcinoembryonic antigen. GCs were determined to be vimentin-positive when cells were positive for both vimentin and carcinoembryonic antigen staining. Results: A total of 86 (32%) of 265 GCs were vimentin positive. There was a statistically significant correlation between vimentin-positive GCs and advanced clinical stage (p&lt;0.001), macroscopic scirrhous-type (p&lt;0.001), histological diffuse-type (p&lt;0.001), lymph node metastasis (p=0.008) and lymphatic invasion (p=0.013). The prognosis of patients with vimentin-positive GCs was significantly (p&lt;0.001) worse than that with vimentin-negative GCs. Conclusion: Vimentin expression might contribute to the high invasive phenotype of GC, and may be a useful biomarker to determine the biological aggressiveness of GC.

    PubMed

  • Phosphorylated Smad2 in Advanced Stage Gastric Carcinoma Reviewed

    Shinto Osamu, Yashiro Masakazu, Toyokawa Takahiro, Nishii Takafumi, Kaizaki Ryoji, Matsuzaki Taro, Noda Satoru, Kubo Naoshi, Tanaka Hiroaki, Doi Yosuke, Ohira Masaichi, Muguruma Kazuya, Sawada Tetsuji, Hirakawa Kosei

    BMC CANCER   10   652   2010.11( ISSN:1471-2407

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    DOI: 10.1186/1471-2407-10-652

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  • Phosphorylated Smad2 in Advanced Stage Gastric Carcinoma Reviewed

    Osamu Shinto, Masakazu Yashiro, Takahiro Toyokawa, Takafumi Nishii, Ryoji Kaizaki, Taro Matsuzaki, Satoru Noda, Naoshi Kubo, Hiroaki Tanaka, Yosuke Doi, Masaichi Ohira, Kazuya Muguruma, Tetsuji Sawada, Kosei Hirakawa

    BMC CANCER   10   652   2010.11( ISSN:1471-2407

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    Background: Transforming growth factor beta (TGF beta) receptor signaling is closely associated with the invasion ability of gastric cancer cells. Although Smad signal is a critical integrator of TGF beta receptor signaling transduction systems, not much is known about the role of Smad2 expression in gastric carcinoma. The aim of the current study is to clarify the role of phosphorylated Smad2 (p-Smad2) in gastric adenocarcinomas at advanced stages.
    Methods: Immunohistochemical staining with anti-p-Smad2 was performed on paraffin-embedded specimens from 135 patients with advanced gastric adenocarcinomas. We also evaluated the relationship between the expression levels of p-Smad2 and clinicopathologic characteristics of patients with gastric adenocarcinomas.
    Results: The p-Smad2 expression level was high in 63 (47%) of 135 gastric carcinomas. The p-Smad2 expression level was significantly higher in diffuse type carcinoma (p = 0.007), tumours with peritoneal metastasis (p = 0.017), and tumours with lymph node metastasis (p = 0.047). The prognosis for p-Smad2-high patients was significantly (p = 0.035, log-rank) poorer than that of p-Smad2-low patients, while a multivariate analysis revealed that p-Smad2 expression was not an independence prognostic factor.
    Conclusion: The expression of p-Smad2 is associated with malignant phenotype and poor prognosis in patients with advanced gastric carcinoma.

    DOI: 10.1186/1471-2407-10-652

    PubMed

  • Effects of valproic acid on the cell cycle and apoptosis through acetylation of histone and tubulin in a scirrhous gastric cancer cell line Reviewed

    Yagi Yasumichi, Fushida Sachio, Harada Shinichi, Kinoshita Jun, Makino Isamu, Oyama Katsunobu, Tajima Hidehiro, Fujita Hideto, Takamura Hiroyuki, Ninomiya Itasu, Fujimura Takashi, Ohta Tetsuo, Yashiro Masakazu, Hirakawa Kosei

    JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH   29   149   2010.11( ISSN:1756-9966

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    DOI: 10.1186/1756-9966-29-149

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  • [A case of type 4 gastric cancer with positive peritoneal lavage cytology, which relapsed at the peritoneum at the time of seven years and eight months after resection]. Reviewed

    Nakamura M, Kubo N, Morimoto J, Tanaka H, Muguruma K, Amano R, Noda E, Inoue T, Takashima T, Yamada N, Yashiro M, Yamashita Y, Maeda K, Onoda N, Sawada T, Nakata B, Ohira M, Ishikawa T, Hirakawa K

    Gan to kagaku ryoho. Cancer & chemotherapy   37 ( 12 )   2436 - 8   2010.11( ISSN:0385-0684

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  • ANTI-TUMOR EFFECT OF LAPATINIB PLUS S-1 AGAINST PANCREATIC CANCER Reviewed

    Nakata Bunzo, Komoto Masahiro, Takashima Tsutomu, Amano Ryosuke, Yamada Nobuya, Nakano Taeko, Yashiro Masakazu, Hirakawa Kosei

    ANNALS OF ONCOLOGY   21   19 - 19   2010.11( ISSN:0923-7534

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  • [Two cases of the primary small intestine cancer successfully treated with S-1 and UFT/LV therapy]. Reviewed

    Lee T, Noda E, Maeda K, Inoue T, Nagahara H, Amano R, Kubo N, Tanaka H, Muguruma K, Takashima T, Yamada N, Yashiro M, Onoda N, Sawada T, Nakata B, Ohira M, Ishikawa T, Hirakawa K

    Gan to kagaku ryoho. Cancer & chemotherapy   37 ( 12 )   2789 - 91   2010.11( ISSN:0385-0684

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  • [Two cases of lymph node recurrence after endoscopic mucosal resection of esophageal cancer]. Reviewed

    Morimoto J, Kubo N, Tanaka H, Ohira M, Muguruma K, Sawada T, Yamada N, Yashiro M, Yamashita Y, Nishiguchi Y, Hirakawa K

    Gan to kagaku ryoho. Cancer & chemotherapy   37 ( 12 )   2379 - 81   2010.11( ISSN:0385-0684

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  • [The outcome of chemotherapy by sorafenib in advanced hepatocellular carcinoma]. Reviewed

    Amano R, Yamada N, Noda E, Kubo N, Tanaka H, Muguruma K, Takashima T, Yashiro M, Maeda K, Onoda N, Sawada T, Nakata B, Ohira M, Ishikawa T, Hirakawa K

    Gan to kagaku ryoho. Cancer & chemotherapy   37 ( 12 )   2676 - 8   2010.11( ISSN:0385-0684

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  • [Effect of PSK on recurrence of stage II/III gastric cancer]. Reviewed

    Tanaka H, Muguruma K, Kubo N, Amano R, Noda E, Yamada N, Yashiro M, Maeda K, Sawada T, Ohira M, Ishikawa T, Hirakawa K

    Gan to kagaku ryoho. Cancer & chemotherapy   37 ( 12 )   2258 - 60   2010.11( ISSN:0385-0684

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  • [Docetaxel with concurrent radiotherapy in patients with inoperable or relapsed oesophageal cancer]. Reviewed

    Kubo N, Morimoto J, Sakurai K, Tanaka H, Muguruma K, Amano R, Noda E, Nagahara H, Takashima T, Yashiro M, Yamada N, Onoda N, Maeda K, Sawada T, Nakata B, Ohira M, Ishikawa T, Hirakawa K

    Gan to kagaku ryoho. Cancer & chemotherapy   37 ( 12 )   2261 - 3   2010.11( ISSN:0385-0684

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  • Proteomic Differential Display Analysis Shows Up-regulation of 14-3-3 Sigma Protein in Human Scirrhous-type Gastric Carcinoma Cells Reviewed

    Kuramitsu Yasuhiro, Baron Byron, Yoshino Shigefumi, Zhang Xiulian, Tanaka Toshiyuki, Yashiro Masakazu, Hirakawa Kosei, Oka Masaaki, Nakamura Kazuyuki

    ANTICANCER RESEARCH   30 ( 11 )   4459 - 4465   2010.11( ISSN:0250-7005

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  • Foretinib (GSK1363089) inhibits growth of gastric cancer cell lines through blockade of inter-receptor tyrosine kinases networks Reviewed

    Mukohara T., Kataoka Y., Tomioka H., Kiyota N., Fujiwara Y., Yashiro M., Hirakawa K., Hirai M., Minami H.

    EJC SUPPLEMENTS   8 ( 7 )   42 - 42   2010.11( ISSN:1359-6349

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  • Proteomic differential display analysis shows up-regulation of 14-3-3 sigma protein in human scirrhous-type gastric carcinoma cells. Reviewed

    Kuramitsu Y, Baron B, Yoshino S, Zhang X, Tanaka T, Yashiro M, Hirakawa K, Oka M, Nakamura K

    Anticancer research   30 ( 11 )   4459 - 65   2010.11( ISSN:0250-7005

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  • [Effect of PSK on recurrence of stage II/III gastric cancer]. Reviewed

    Tanaka H, Muguruma K, Kubo N, Amano R, Noda E, Yamada N, Yashiro M, Maeda K, Sawada T, Ohira M, Ishikawa T, Hirakawa K

    Gan to kagaku ryoho. Cancer & chemotherapy   37 ( 12 )   2258 - 2260   2010.11( ISSN:0385-0684

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    PubMed

  • [Effect of PSK on recurrence of stage II/III gastric cancer]. Reviewed

    Tanaka H, Muguruma K, Kubo N, Amano R, Noda E, Yamada N, Yashiro M, Maeda K, Sawada T, Ohira M, Ishikawa T, Hirakawa K

    Gan to kagaku ryoho. Cancer & chemotherapy   37 ( 12 )   2258 - 60   2010.11( ISSN:0385-0684

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    PubMed

  • [A case of type 4 gastric cancer with positive peritoneal lavage cytology, which relapsed at the peritoneum at the time of seven years and eight months after resection]. Reviewed

    Nakamura M, Kubo N, Morimoto J, Tanaka H, Muguruma K, Amano R, Noda E, Inoue T, Takashima T, Yamada N, Yashiro M, Yamashita Y, Maeda K, Onoda N, Sawada T, Nakata B, Ohira M, Ishikawa T, Hirakawa K

    Gan to kagaku ryoho. Cancer & chemotherapy   37 ( 12 )   2436 - 8   2010.11( ISSN:0385-0684

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    PubMed

  • Effects of valproic acid on the cell cycle and apoptosis through acetylation of histone and tubulin in a scirrhous gastric cancer cell line. Reviewed

    Yagi Y, Fushida S, Harada S, Kinoshita J, Makino I, Oyama K, Tajima H, Fujita H, Takamura H, Ninomiya I, Fujimura T, Ohta T, Yashiro M, Hirakawa K

    Journal of experimental & clinical cancer research : CR   29   149   2010.11( ISSN:0392-9078

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    DOI: 10.1186/1756-9966-29-149

    PubMed

  • [The outcome of chemotherapy by sorafenib in advanced hepatocellular carcinoma]. Reviewed

    Amano R, Yamada N, Noda E, Kubo N, Tanaka H, Muguruma K, Takashima T, Yashiro M, Maeda K, Onoda N, Sawada T, Nakata B, Ohira M, Ishikawa T, Hirakawa K

    Gan to kagaku ryoho. Cancer & chemotherapy   37 ( 12 )   2676 - 8   2010.11( ISSN:0385-0684

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    PubMed

  • Stage II/III胃癌に対するPSK術後補助療法のResponderの予測 Reviewed

    田中 浩明, 六車 一哉, 久保 尚士, 天野 良亮, 野田 英児, 山田 靖哉, 八代 正和, 前田 清, 澤田 鉄二, 大平 雅一, 石川 哲郎, 平川 弘聖

    癌と化学療法   37 ( 12 )   2258 - 2260   2010.11( ISSN:0385-0684

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    PSKは化学療法との併用により、胃癌切除後の生存率を改善させる。今回われわれは、教室で切除したStage II/III胃癌術後補助化学療法を施行した254例において化学療法単独群(138例)、PSK併用群(116例)にて術後再発に及ぼす臨床病理学因子について比較検討した。無再発生存期間は、両群において有意差は認めなかった。PSK併用群にて再発に関与する因子として、pT、脈管侵襲、pStage、腫瘍径の因子が単変量解析において有意差を認めた。多変量解析では脈管侵襲が独立した因子と考えられた。このことより、Stage II/III胃癌に対するPSK術後補助療法において原発巣の脈管侵襲が高度な場合は、再発の危険性が高くなることが示唆された。今後、PSK有効症例と無効症例を予測し得るバイオマーカーの検討が必要である。(著者抄録)

  • S-1、UFT/LV療法が奏効した原発性小腸癌の2例 Reviewed

    李 友浩, 野田 英児, 前田 清, 井上 透, 永原 央, 天野 良亮, 久保 尚士, 田中 浩明, 六車 一哉, 高島 勉, 山田 靖哉, 八代 正和, 小野田 尚佳, 澤田 鉄二, 仲田 文蔵, 大平 雅一, 石川 哲郎, 平川 弘聖

    癌と化学療法   37 ( 12 )   2789 - 2791   2010.11( ISSN:0385-0684

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    原発性小腸癌は消化管癌のなかでもまれであるが、進行・再発例も多い。しかしながら術後補助化学療法や再発例に対する化学療法は、症例報告が散見される程度であり、治療レジメンに一定の見解はない。今回、原発性小腸癌に対する経口化学療法としてS-1、UFT/LV療法が有効であった2例を経験した。(著者抄録)

  • Proteomic Differential Display Analysis Shows Up-regulation of 14-3-3 Sigma Protein in Human Scirrhous-type Gastric Carcinoma Cells Reviewed

    Yasuhiro Kuramitsu, Byron Baron, Shigefumi Yoshino, Xiulian Zhang, Toshiyuki Tanaka, Masakazu Yashiro, Kosei Hirakawa, Masaaki Oka, Kazuyuki Nakamura

    ANTICANCER RESEARCH   30 ( 11 )   4459 - 4465   2010.11( ISSN:0250-7005

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    This study performed proteomic differential display analysis of human scirrhous-type gastric carcinoma (SGC) cell lines and normal gastric mucosa (NGM) tissues by using two-dimensional gel electrophoresis (2-DE) and liquid chromatography tandem mass spectrometry (LC-MS/MS). The human SGC cell lines were OCUM-1, OCUM-2M, OCUM-2MLN, OCUM-2D, OCUM-D3, OCUM-9 and OCUM-12. Among the SGC cell lines and the NGM tissues, 28 protein spots were found whose expression levels were different from the results of 2-DE: 19 protein spots appeared higher, and 9 other protein spots appeared lower in SGCs than in NGM tissues. These spots were analysed by LC-MS/MS analysis and identified by a peptide sequence tag. Identified increased spots included elongation factor 1-beta, 14-3-3 sigma, tropomyosin alpha-4 chain, protein DJ-1, nucleoside diphosphate kinase A, elongation factor Tu and peroxiredoxin-1. Western blot analysis showed increased protein level of 14-3-3 sigma in SGCs. Although OCUM-1 and AGS (gastric cancer) showed up-regulation of 14-3-3 sigma, MiaPaca-2 (pancreatic cancer), Huh-7 (HCC) and NCI-H2052 (malignant pleural mesothelioma) showed very weak expression of 14-3-3 sigma. The up-regulation of 14-3-3 sigma may play an important role in SGC carcinogenesis and progression and may be used as a diagnostic biomarker of SGC.

    PubMed

  • [Two cases of the primary small intestine cancer successfully treated with S-1 and UFT/LV therapy]. Reviewed

    Lee T, Noda E, Maeda K, Inoue T, Nagahara H, Amano R, Kubo N, Tanaka H, Muguruma K, Takashima T, Yamada N, Yashiro M, Onoda N, Sawada T, Nakata B, Ohira M, Ishikawa T, Hirakawa K

    Gan to kagaku ryoho. Cancer & chemotherapy   37 ( 12 )   2789 - 91   2010.11( ISSN:0385-0684

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    PubMed

  • [Two cases of lymph node recurrence after endoscopic mucosal resection of esophageal cancer]. Reviewed

    Morimoto J, Kubo N, Tanaka H, Ohira M, Muguruma K, Sawada T, Yamada N, Yashiro M, Yamashita Y, Nishiguchi Y, Hirakawa K

    Gan to kagaku ryoho. Cancer & chemotherapy   37 ( 12 )   2379 - 81   2010.11( ISSN:0385-0684

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    PubMed

  • 局所進行再発食道癌に対するDocetaxel併用化学放射線療法 Reviewed

    久保 尚士, 森本 純也, 櫻井 克宣, 田中 浩明, 六車 一哉, 天野 良亮, 野田 英児, 永原 央, 高島 勉, 八代 正和, 山田 靖哉, 小野田 尚佳, 前田 清, 澤田 鉄二, 仲田 文造, 大平 雅一, 石川 哲郎, 平川 弘聖

    癌と化学療法   37 ( 12 )   2261 - 2263   2010.11( ISSN:0385-0684

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    docetaxel(DOC)は外来投与が可能で、放射線の増感作用を有する新規抗癌剤である。今回、われわれは進行再発食道癌8例に対してDOC併用化学放射線療法(CRT)を施行したのでその効果と安全性を報告する。対象と方法:対象は縦隔リンパ節再発6例、併存疾患による手術不能例1例、FP療法後の二次治療が1例であった。DOCは10mg/m2を週1回×6週点滴投与、放射線は2Gy/回計60Gyを照射した。結果:効果判定はCR2例、PR5例、SD1例で奏効率87.5%であった。有害事象はgrade 3以上の血液毒性、grade 2以上の非血液毒性ともに認められず、経口摂取ができなかった1例以外は全例が外来にて治療可能であった。平均奏効期間は6.6ヵ月、生存期間中央値は13.3ヵ月であった。まとめ:局所進行再発食道癌に対するDOC-CRTは高い奏効率を認め、患者の生活の質を維持できる優れた治療と考えられた。(著者抄録)

  • 進行肝細胞癌に対するソラフェニブの治療成績 Reviewed

    天野 良亮, 山田 靖哉, 野田 英児, 久保 尚士, 田中 浩明, 六車 一哉, 高島 勉, 八代 正和, 前田 清, 小野田 尚佳, 澤田 鉄二, 仲田 文造, 大平 雅一, 石川 哲郎, 平川 弘聖

    癌と化学療法   37 ( 12 )   2676 - 2678   2010.11( ISSN:0385-0684

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    肝外病変を伴う進行肝細胞癌に対するソラフェニブの治療成績を検討した。対象は2009年6~10月までに当科でソラフェニブを投与した進行肝細胞癌8例。有害事象は7例(87.5%)に認め、grade 3以上は手足症候群2例、疲労1例であった。その他にgrade 2の高血圧3例、grade 1の下痢2例、食欲不振4例を認めた。減量投与移行は3例、休薬は2例に行ったが全症例継続投与可能であった。治療効果はCR/PR0例、SD2例、PD6例、予後はソラフェニブ投与開始からは101日であった。8例中6例が原病死しており、現在2例が継続投与中である。現時点での進行肝細胞癌に対するソラフェニブの治療成績は満足できるものではなかった。高率に有害事象を認めるが、減量・休薬による投与法の工夫によって継続投与は可能であった。(著者抄録)

  • 胸部食道癌内視鏡治療後の遅発性リンパ節再発に対し根治術を施行した2例 Reviewed

    森本 純也, 久保 尚士, 田中 浩明, 大平 雅一, 六車 一哉, 澤田 鉄二, 山田 靖哉, 八代 正和, 山下 好人, 西口 幸雄, 平川 弘聖

    癌と化学療法   37 ( 12 )   2379 - 2381   2010.11( ISSN:0385-0684

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    食道表在癌に対する粘膜切除術は外科手術と比較して、低侵襲であり有用な治療法の一つである。しかし壁深達度MM以深の場合、リンパ節転移を伴う可能性があり、その後の再発に注意を要する。今回、われわれは内視鏡的粘膜切除(EMR)後にリンパ節再発を来し根治術を施行した2例を経験したので報告する。症例1は49歳、男性。2005年10月、0-IIc型の食道癌に対しEMRを施行した。組織学的検索にてpT1b-SM3、ly0、v0であったため、根治的化学放射線療法を追加した。2007年6月胃噴門小彎側に4cm大のリンパ節(#1)再発を認め、8月に根治術を施行した。病理検査では#1以外に#8aにも転移を認めた。症例2は68歳、男性。2006年8月、0-IIa型食道癌に対しEMRを施行した。組織学的検索にてpT1a-MM、ly0、v0のため、補助化学療法を施行した。2009年2月胃噴門部に約2cm大のリンパ節(#1)再発を認め、6月に根治術を施行した。病理検査では#1以外に#108にも転移を認めた。(著者抄録)

  • 胃切除7年8ヵ月後に腹膜播種にて再発したCY陽性4型胃癌の1例 Reviewed

    中村 雅憲, 久保 尚士, 森本 純也, 田中 浩明, 六車 一哉, 天野 良亮, 野田 英児, 井上 透, 高島 勉, 山田 靖哉, 八代 正和, 山下 好人, 前田 清, 小野田 尚佳, 澤田 鉄二, 仲田 文造, 大平 雅一, 石川 哲郎, 平川 弘聖

    癌と化学療法   37 ( 12 )   2436 - 2438   2010.11( ISSN:0385-0684

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    症例は55歳、女性。食思不振、体重減少を主訴に来院。上部消化管内視鏡検査にて胃粘膜の浮腫性変化とgiant foldを認め、生検にて低分化型腺癌と診断された。腹部CT検査では腹水や肝転移は認めなかったが、胃壁の肥厚と多数のリンパ節腫大を指摘された。術前診断T3N2M0、Stage IIIBの4型胃癌と診断し、胃全摘術を施行した。明らかな腹膜播種は認めなかったものの、腹腔洗浄細胞診が陽性であった。術後はS-1単剤による補助療法を4年間行い、再発は認めなかった。しかし7年8ヵ月後にCT検査にて腹膜播種再発と診断され、現在再度S-1にて治療中である。(著者抄録)

  • Elevated dietary linoleic acid increases gastric carcinoma cell invasion and metastasis in mice Reviewed

    Matsuoka T., Adair J. E., Lih F. B., Hsi L. C., Rubino M., Eling T. E., Tomer K. B., Yashiro M., Hirakawa K., Olden K., Roberts J. D.

    BRITISH JOURNAL OF CANCER   103 ( 8 )   1182 - 1191   2010.10( ISSN:0007-0920

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    DOI: 10.1038/sj.bjc.6605881

  • Significance of Keratinocyte Growth Factor Receptor in the Proliferation of Biliary Tract Cancer Reviewed

    Amano Ryosuke, Yamada Nobuya, Doi Yosuke, Yashiro Masakazu, Ohira Masaichi, Miwa Atsushi, Hirakawa Kosei

    ANTICANCER RESEARCH   30 ( 10 )   4115 - 4121   2010.10( ISSN:0250-7005

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  • Significance of keratinocyte growth factor receptor in the proliferation of biliary tract cancer. Reviewed

    Amano R, Yamada N, Doi Y, Yashiro M, Ohira M, Miwa A, Hirakawa K

    Anticancer research   30 ( 10 )   4115 - 21   2010.10( ISSN:0250-7005

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    PubMed

  • Significance of Keratinocyte Growth Factor Receptor in the Proliferation of Biliary Tract Cancer Reviewed

    Ryosuke Amano, Nobuya Yamada, Yosuke Doi, Masakazu Yashiro, Masaichi Ohira, Atsushi Miwa, Kosei Hirakawa

    ANTICANCER RESEARCH   30 ( 10 )   4115 - 4121   2010.10( ISSN:0250-7005

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    Background/Aim: Biliary tract carcinoma (BTC) has extremely poor prognosis because of rapid cancer cell proliferation. The aim of this study was to clarify the significance of keratinocyte growth factor receptor (KGFR) in the proliferation of BTC. Materials and Methods: The expression of KGFR in 34 surgical specimens of BTC was investigated by immunohistochemical staining. The effect of Ki23057, a small synthetic molecule that interrupts the autophosphorylation of KGFR, on the proliferation of human BTC cell lines was examined in vitro and in vivo. Results: The prognosis for BTC patients with KGFR-positive tumour was significantly poorer than that for those with KGFR-negative tumour. KGF significantly stimulated the proliferation of BTC cell lines. Ki23057 significantly decreased the growth of BTC cells in vitro and in vivo. Conclusion: KGFR may play an important role in the proliferation of BTC. KGFR phosphorylation inhibitor, Ki23057, therefore appears to be therapeutically promising in BTC.

    PubMed

  • Significance of keratinocyte growth factor receptor in the proliferation of biliary tract cancer. Reviewed

    Amano R, Yamada N, Doi Y, Yashiro M, Ohira M, Miwa A, Hirakawa K

    Anticancer research   30 ( 10 )   4115 - 21   2010.10( ISSN:0250-7005

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  • Elevated dietary linoleic acid increases gastric carcinoma cell invasion and metastasis in mice Reviewed

    T. Matsuoka, J. E. Adair, F. B. Lih, L. C. Hsi, M. Rubino, T. E. Eling, K. B. Tomer, M. Yashiro, K. Hirakawa, K. Olden, J. D. Roberts

    BRITISH JOURNAL OF CANCER   103 ( 8 )   1182 - 1191   2010.10( ISSN:0007-0920

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    BACKGROUND: Dietary (n-6)-polyunsaturated fatty acids influence cancer development, but the mechanisms have not been well characterised in gastric carcinoma.
    METHODS: We used two in vivo models to investigate the effects of these common dietary components on tumour metastasis. In a model of experimental metastasis, immunocompromised mice were fed diets containing linoleic acid (LA) at 2% (LLA), 8% (HLA) or 12% (VHLA) by weight and inoculated intraperitoneally (i.p.) with human gastric carcinoma cells (OCUM-2MD3). To model spontaneous metastasis, OCUM-2MD3 tumours were grafted onto the stomach walls of mice fed with the different diets. In in vitro assays, we investigated invasion and ERK phosphorylation of OCUM-2MD3 cells in the presence or absence of LA. Finally, we tested whether a cyclooxygenase (COX) inhibitor, indomethacin, could block peritoneal metastasis in vivo.
    RESULTS: Both the HLA and VHLA groups showed increased incidence of tumour nodules (LA: 53%; HLA: 89%; VHLA: 100%; P&lt;0.03); the VHLA group also displayed increased numbers of tumour nodules and higher total volume relative to LLA group in experimental metastasis model. Both liver invasion (78%) and metastasis to the peritoneal cavity (67%) were more frequent in VHLA group compared with the LLA group (22% and 11%, respectively; P&lt;0.03) in spontaneous metastasis model. We also found that the invasive ability of these cells is greatly enhanced when exposed to LA in vitro. Linoleic acid also increased invasion of other scirrhous gastric carcinoma cells, OCUM-12, NUGC3 and MKN-45. Linoleic acid effect on OCUM-2MD3 cells seems to be dependent on phosphorylation of ERK. The data suggest that invasion and phosphorylation of ERK were dependent on COX. Indomethacin decreased the number of tumours and total tumour volume in both LLA and VHLA groups. Finally, COX-1, which is known to be an important enzyme in the generation of bioactive metabolites from dietary fatty acids, appears to be responsible for the increased metastatic behaviour of OCUM-2MD3 cells in the mouse model.
    CONCLUSION: Dietary LA stimulates invasion and peritoneal metastasis of gastric carcinoma cells through COX-catalysed metabolism and activation of ERK, steps that compose pathway potentially amenable to therapeutic intervention. British Journal of Cancer (2010) 103, 1182-1191. doi:10.1038/sj.bjc.6605881 www.bjcancer.com Published online 14 September 2010 (C) 2010 Cancer Research UK

    DOI: 10.1038/sj.bjc.6605881

  • 胃癌における多能性維持因子発現と癌幹細胞との関連についての検討 Reviewed

    松岡 順子, 八代 正和, 柏木 伸一郎, 加藤 幸裕, 冬廣 雄彦, 土井 洋輔, 野田 諭, 久保 尚士, 田中 浩明, 六車 一哉, 井上 透, 山田 靖哉, 澤田 鉄二, 大平 雅一, 石川 哲郎, 平川 弘聖

    日本消化器外科学会雑誌   43 ( Suppl.2 )   180 - 180   2010.10( ISSN:0386-9768 ( eISSN:1348-9372

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  • Biodistribution of humanized anti-VEGF monoclonal antibody/bevacizumab on peritoneal metastatic models with subcutaneous xenograft of gastric cancer in mice Reviewed

    Yagi Yasumichi, Fushida Sachio, Harada Shinichi, Tsukada Tomoya, Kinoshita Jun, Oyama Katsunobu, Fujita Hideto, Ninomiya Itasu, Fujimura Takashi, Kayahara Masato, Kinuya Seigo, Yashiro Masakazu, Hirakawa Kousei, Ohta Tetsuo

    CANCER CHEMOTHERAPY AND PHARMACOLOGY   66 ( 4 )   745 - 753   2010.09( ISSN:0344-5704

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    DOI: 10.1007/s00280-009-1219-y

    PubMed

  • Biodistribution of humanized anti-VEGF monoclonal antibody/bevacizumab on peritoneal metastatic models with subcutaneous xenograft of gastric cancer in mice Reviewed

    Yasumichi Yagi, Sachio Fushida, Shinichi Harada, Tomoya Tsukada, Jun Kinoshita, Katsunobu Oyama, Hideto Fujita, Itasu Ninomiya, Takashi Fujimura, Masato Kayahara, Seigo Kinuya, Masakazu Yashiro, Kousei Hirakawa, Tetsuo Ohta

    CANCER CHEMOTHERAPY AND PHARMACOLOGY   66 ( 4 )   745 - 753   2010.09( ISSN:0344-5704

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    Vascular endothelial growth factor (VEGF) is correlated with peritoneal metastasis of gastric cancer, increasing vascular permeability accompanied by accumulation of ascites. The aim of the current study is to investigate the biodistribution of bevacizumab in a peritoneal metastatic model of gastric cancer and to clarify which is more suited to treatment of peritoneal metastasis, systemic or regional therapy.
    A highly peritoneal-seeding cell line of gastric cancer, OCUM-2MD3, which exhibited high production and release of VEGF was used in this study. The biodistribution of bevacizumab was investigated using peritoneal metastatic models together with subcutaneous xenografts, and (125)I-radiolabelled bevacizumab was administrated to these models subcutaneously (s.c.) or intraperitoneally (i.p.), respectively. In addition, the anti-tumor response of bevacizumab and paclitaxel was assessed as single agents or in combination using peritoneal metastatic models.
    In the analysis of biodistribution, (125)I-bevacizumab administrated i.p. indicated low peritoneal clearance. On the other hand, s.c. administration of (125)I-bevacizumab showed preferential accumulation in subcutaneous tumors and peritoneal nodules, with a high blood concentration. In peritoneal metastatic models, the effects of bevacizumab were found for both the growth inhibition of peritoneal nodules (P &lt; 0.01) and the reduction of ascites (P &lt; 0.05). These effects were more prominent by s.c. administration compared with i.p. administration and were increased in combination with i.p. paclitaxel.
    Bevacizumab should be administrated systemically compared to regionally, and the combination with i.p. paclitaxel has a potential to be useful for patients with peritoneal metastasis of gastric cancer.

    DOI: 10.1007/s00280-009-1219-y

    PubMed

  • Combination effect of a TGF-β receptor kinase inhibitor with 5-FU analog S1 on lymph node metastasis of scirrhous gastric cancer in mice Reviewed

    SHINTO Osamu, YASHIRO Masakazu, KAWAJIRI Hidemi, SHIMIZU Kiyoshi, SHIMIZU Toshiyuki, MIWA Atsushi, HIRAKAWA Kosei

    Cancer science   101 ( 8 )   1846 - 1852   2010.08( ISSN:13479032

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    CiNii Article

  • Combination effect of a TGF-β receptor kinase inhibitor with 5-FU analog S1 on lymph node metastasis of scirrhous gastric cancer in mice Reviewed

    SHINTO Osamu, YASHIRO Masakazu, KAWAJIRI Hidemi, SHIMIZU Kiyoshi, SHIMIZU Toshiyuki, MIWA Atsushi, HIRAKAWA Kosei

    101 ( 8 )   1846 - 1852   2010.08( ISSN:13479032

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    CiNii Article

  • Combination effect of a TGF-beta receptor kinase inhibitor with 5-FU analog S1 on lymph node metastasis of scirrhous gastric cancer in mice Reviewed

    Shinto Osamu, Yashiro Masakazu, Kawajiri Hidemi, Shimizu Kiyoshi, Shimizu Toshiyuki, Miwa Atsushi, Hirakawa Kosei

    CANCER SCIENCE   101 ( 8 )   1846 - 1852   2010.08( ISSN:1347-9032

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    DOI: 10.1111/j.1349-7006.2010.01606.x

    PubMed

  • Combination effect of a TGF-beta receptor kinase inhibitor with 5-FU analog S1 on lymph node metastasis of scirrhous gastric cancer in mice Reviewed

    Osamu Shinto, Masakazu Yashiro, Hidemi Kawajiri, Kiyoshi Shimizu, Toshiyuki Shimizu, Atsushi Miwa, Kosei Hirakawa

    CANCER SCIENCE   101 ( 8 )   1846 - 52   2010.08( ISSN:1347-9032

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    Transforming growth factor-beta (TGF-beta) signals are closely associated with the distant metastases of gastric cancer. The aim of this study was to clarify the effect of a TGF-beta receptor I (T beta R-I) phosphorylation inhibitor, Ki26894, in combination with anticancer drugs, on the lymph node (LN) metastasis of scirrhous gastric cancer. A novel T beta R-I kinase inhibitor, Ki26894, inhibits the phosphorylation of Smad2 at the ATP binding site of T beta R-I. S1 is a 5-fluorouracil analog. The human scirrhous gastric cancer cell line OCUM-2MLN and the human gastric fibroblasts NF-33 were used. OCUM-2MLM cells in the upper well and NF-33 cells in the lower well were co-incubated with or without Ki26894. The proliferation of OCUM-2MLN cells was significantly stimulated by co-culture with NF-33 cells. Ki26894 significantly suppressed the growth interactions between OCUM-2MLN cells and NF-33 cells. Gastric cancer models established by orthotopic inoculation of OCUM-2MLN cells showed diffusely infiltrating gastric adenocarcinoma accompanied by LN metastases. We divided these mice into four groups, (control vehicle, Ki26894, S1, Ki26894 plus S1), and examined the effect of Ki26894 and/or S1 on phosphorylation of Smad2, tumor size, LN metastases, and lymphatic involvements. Ki26894 inhibited the Smad2 phosphorylation of cancer cells and decreased the extent of lymphatic involvement, compared with the control or S1 only group. The Ki26894 plus S1 administration group significantly suppressed tumor growth and decreased LN metastasis more effectively than either alone. These findings suggested that the T beta R-I kinase inhibitor with S1 is useful for the treatment of scirrhous gastric carcinoma with LN metastasis. (Cancer Sci 2010).

    DOI: 10.1111/j.1349-7006.2010.01606.x

    PubMed

  • マウス硬化性胃癌のリンパ節転移に対するTGFβ受容体キナーゼ阻害剤と5-FU類似体S1の併用効果(Combination effect of a TGF-β receptor kinase inhibitor with 5-FU analog S1 on lymph node metastasis of scirrhous gastric cancer in mice) Reviewed

    Shinto Osamu, Yashiro Masakazu, Kawajiri Hidemi, Shimizu Kiyoshi, Shimizu Toshiyuki, Miwa Atsushi, Hirakawa Kosei

    Cancer Science   101 ( 8 )   1846 - 1852   2010.08( ISSN:1347-9032

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    硬化性胃癌のリンパ節転移に対するTGFβ受容体キナーゼ阻害剤Ki26894と抗癌薬S1の併用効果をin vitroおよびin vivoで検討した。ヒト硬化性胃癌細胞株OCUM-2MLNの増殖はヒト胃線維芽細胞NF-33と共培養することにより、有意に促進された。Ki26894はOCUM-2MLNとNF-33との相互作用を有意に阻害した。OCUM-2MLN接種マウスは、浸潤性胃腺癌とリンパ節転移を示した。Ki26894は対照或いはS1単独投与動物と比較して、癌細胞のSmad2リン酸化とリンパ節転移を阻害した。Ki26894+S1は腫瘍増殖とリンパ節転移を各薬物の単独投与時よりも効果的に阻害した。TGFβ受容体キナーゼ阻害剤とS1の併用は、リンパ節転移を伴う硬化性胃癌の治療に有用であることが示唆された。

  • Significance of E-cadherin expression in triple-negative breast cancer Reviewed

    Kashiwagi S., Yashiro M., Takashima T., Nomura S., Noda S., Kawajiri H., Ishikawa T., Wakasa K., Hirakawa K.

    BRITISH JOURNAL OF CANCER   103 ( 2 )   249 - 255   2010.07( ISSN:0007-0920

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    DOI: 10.1038/sj.bjc.6605735

  • Significance of E-cadherin expression in triple-negative breast cancer. Reviewed

    Kashiwagi S, Yashiro M, Takashima T, Nomura S, Noda S, Kawajiri H, Ishikawa T, Wakasa K, Hirakawa K

    British journal of cancer   103 ( 2 )   249 - 55   2010.07( ISSN:0007-0920

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    DOI: 10.1038/sj.bjc.6605735

    PubMed

  • Myofibroblasts are associated with the progression of scirrhous gastric carcinoma Reviewed

    Yuhiko Fuyuhiro, Masakazu Yashiro, Satoru Noda, Shinichiro Kashiwagi, Junko Matsuoka, Yosuke Doi, Yukihiro Kato, Kazuya Muguruma, Tetsuji Sawada, Kosei Hirakawa

    EXPERIMENTAL AND THERAPEUTIC MEDICINE   1 ( 4 )   547 - 551   2010.07( ISSN:1792-0981

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    Fibroblasts, particularly myofibroblasts, affect the malignant progression of cancer cells in vitro. However, to date few reports have addressed the clinical significance of myofibroblasts in the gastric cancer microenvironment. This study examined the correlation between myofibroblast expression and clinicopathological features in gastric carcinoma. A total of 265 primary gastric tumors resected by gastrectomy were stained with antibodies against alpha-smooth muscle actin and vimentin. Stromal cells positive for vimentin were considered to be fibroblasts. Myofibroblasts were defined as fibroblasts positive for alpha-smooth muscle staining. Myofibroblast-positive gastric carcinoma was established when myofibroblasts accounted for more than 25% of fibroblasts in the cancer stroma. Myofibroblast expression was positive in 92 (35%) of the 265 gastric carcinomas. Myofibroblast expression showed a significantly (p &lt; 0.001) high frequency in advanced gastric cancers (76 of 146), in comparison to the early stage cancers (16 of 119). Taken together, there was a statistically significant correlation between myofibroblast expression and scirrhous type gastric cancer (p &lt; 0.001), lymph node metastasis (p &lt; 0.001), lymphatic invasion (p &lt; 0.001) and peritoneal dissemination (p=0.005). The prognosis of patients with tumors positive for myofibroblast expression was significantly (p &lt; 0.001) worse, while a multivariate analysis revealed that myofibroblast expression was not an independent prognostic factor. These findings suggest that myofibroblasts are associated with scirrhous gastric cancer. Overexpression of myofibroblasts may therefore be a useful prognostic indicator of gastric carcinoma.

    DOI: 10.3892/etm_00000086

    PubMed

  • Mutations in TGFbeta-RII and BAX mediate tumor progression in the later stages of colorectal cancer with microsatellite instability Reviewed

    Yashiro Masakazu, Hirakawa Kosei, Boland C. Richard

    BMC CANCER   10   303   2010.06( ISSN:1471-2407

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    DOI: 10.1186/1471-2407-10-303

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  • Mutations in TGFbeta-RII and BAX mediate tumor progression in the later stages of colorectal cancer with microsatellite instability Reviewed

    Masakazu Yashiro, Kosei Hirakawa, C. Richard Boland

    BMC CANCER   10   303   2010.06( ISSN:1471-2407

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    Background: Microsatellite instability (MSI) occurs in 15% of colorectal cancers (CRC). The genetic targets for mutation in the MSI phenotype include somatic mutations in the transforming growth factor beta receptor typeII (TGFbetaRII), BAX, hMSH3 and hMSH6. It is not clear how mutations of these genes mediate tumor progression in the MSI pathway, and the temporal sequence of these mutations remains uncertain. In this study, early stage CRCs were examined for frameshift mutations in these target genes, and compared with late stage tumors and CRC cell lines.
    Methods: We investigated 6 CRC cell lines and 71 sporadic CRCs, including 61 early stage cancers and 10 late stage cancers. Mutations of repetitive mononucleotide tracts in the coding regions of TGFbetaRII, BAX, hMSH3, hMSH6, IGFIIR and Fas antigen were identified by direct sequencing.
    Results: Thirteen (18.3%) of 71 CRC, including 9/61 (14.7%) early stage cancers and 4/10 (40%) late stage cancers, were identified as MSI and analyzed for frameshift mutations. No mutation in the target genes was observed in any of the 9 early stage MSI CRCs. In contrast, frameshift mutations of TGFbetaRII, BAX, hMSH3 and hMSH6 were present in 3/4 late stage MSI tumors. There is a statistical association (p = 0.014) between mutation in any one gene and tumor stage.
    Conclusions: TGFbetaRII, BAX, hMSH3 and hMSH6 mutations are relatively late events in the genesis of MSI CRCs. The frameshift mutations in these target genes might mediate progression from early to late stage cancer, rather than mediating the adenoma to carcinoma transition.

    DOI: 10.1186/1471-2407-10-303

    PubMed

  • Significance of phospho-vascular endothelial growth factor receptor-2 expression in pancreatic cancer Reviewed

    DOI Yosuke, YASHIRO Masakazu, YAMADA Nobuya, AMANO Ryosuke, OHIRA Go, KOMOTO Masahiro, NODA Satoru, KASHIWAGI Shinichiro, KATO Yukihiro, FUYUHIRO Yuhiko, HIRAKAWA Kosei

    Cancer science   101 ( 6 )   1529 - 1535   2010.06( ISSN:13479032

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  • Significance of phospho-vascular endothelial growth factor receptor-2 expression in pancreatic cancer Reviewed

    DOI Yosuke, YASHIRO Masakazu, YAMADA Nobuya, AMANO Ryosuke, OHIRA Go, KOMOTO Masahiro, NODA Satoru, KASHIWAGI Shinichiro, KATO Yukihiro, FUYUHIRO Yuhiko, HIRAKAWA Kosei

    101 ( 6 )   1529 - 1535   2010.06( ISSN:13479032

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  • Significance of phospho-vascular endothelial growth factor receptor-2 expression in pancreatic cancer Reviewed

    Doi Yosuke, Yashiro Masakazu, Yamada Nobuya, Amano Ryosuke, Ohira Go, Komoto Masahiro, Noda Satoru, Kashiwagi Shinichiro, Kato Yukihiro, Fuyuhiro Yuhiko, Hirakawa Kosei

    CANCER SCIENCE   101 ( 6 )   1529 - 1535   2010.06( ISSN:1347-9032

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    DOI: 10.1111/j.1349-7006.2010.01547.x

    PubMed

  • Significance of phospho-vascular endothelial growth factor receptor-2 expression in pancreatic cancer Reviewed

    Yosuke Doi, Masakazu Yashiro, Nobuya Yamada, Ryosuke Amano, Go Ohira, Masahiro Komoto, Satoru Noda, Shinichiro Kashiwagi, Yukihiro Kato, Yuhiko Fuyuhiro, Kosei Hirakawa

    CANCER SCIENCE   101 ( 6 )   1529 - 35   2010.06( ISSN:1347-9032

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    Vascular endothelial growth factor receptors (VEGFRs) are mainly expressed by endothelial cells, but they are also expressed by some cancer cells, including pancreatic cancer. The objective of this study was to evaluate the significance of VEGFRs expression in pancreatic cancer cells. A total of 107 primary pancreatic tumors were stained with antibodies against VEGFR-1, VEGFR-2, phospho-VEGFR-2 (pVEGFR-2), VEGFR-3, VEGF-A, VEGF-C, and VEGF-D. VEGFR-2 and pVEGFR-2 expression were positive in 74 (69%) and 54 (50%) of 107 pancreatic cancers. There was a significant correlation (P &lt; 0.001) between VEGFR-2 expression and pVEGFR-2 expression. pVEGFR-2 was significantly associated with invasion to the anterior capsule of pancreas (P = 0.032) and arterial invasion (P = 0.012). In contrast, VEGFR-1 and VEGFR-3 expression was only observed in 13 (12%) and 15 (14%) of 107 pancreatic cancers, and was not associated with any clinicopathological features. The prognosis of pVEGFR-2 positive patients with stage IIA tumors was significantly (P = 0.0441) poorer than that of pVEGFR-2-negative patients. VEGF-A, VEGF-C, and VEGF-D expression was positive in 42 (39%), 82 (77%), and 39 (36%) of 107 pancreatic cancers, respectively. The prognosis for VEGF-A-positive patients was significantly (P = 0.0425) poor, but not for VEGF-C-positive and VEGF-D-positive patients. A multivariate analysis indicated pVEGFR-2 expression to be an independent prognostic factor, but not VEGF-A. These findings suggested that VEGFR-2 signaling might therefore be associated with the prognosis of patients with pancreatic cancer. The expression of pVEGFR-2 might be a novel predictive prognostic marker for patients with pancreatic cancers, especially at clinical stage IIA. (Cancer Sci 2010).

    DOI: 10.1111/j.1349-7006.2010.01547.x

    PubMed

  • 膵癌におけるリン酸化型血管内皮増殖因子受容体-2の意義(Significance of phospho-vascular endothelial growth factor receptor-2 expression in pancreatic cancer) Reviewed

    Doi Yosuke, Yashiro Masakazu, Yamada Nobuya, Amano Ryosuke, Ohira Go, Komoto Masahiro, Noda Satoru, Kashiwagi Shinichiro, Kato Yukihiro, Fuyuhiro Yuhiko, Hirakawa Kosei

    Cancer Science   101 ( 6 )   1529 - 1535   2010.06( ISSN:1347-9032

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    一連のVEGFおよびVEGF受容体(VEGFR)に対する抗体を用いて原発性膵癌107例の組織を染色した。VEGFR-2およびリン酸化型VEGFR-2(pVEGFR-2)がそれぞれ71例(69%)および54例(50%)で陽性であった。VEGFR-2発現とpVEGFR-2発現は相関した。pVEGFR-2発現は膵前方被膜浸潤および動脈浸潤と関連した。VEGFR-1およびVEGFR-3の発現はそれぞれ13例(12%)および15例(14%)にのみ観察され、臨床病理特性との相関はなかった。ステージIIAでpVEGFR-2陽性の患者の予後は陰性患者よりも不良であった。VEGF-A、VEGF-CおよびVEGF-Dの発現はそれぞれ42例(39%)、82例(77%)および39例(36%)で陽性であった。VEGF-A陽性患者の予後は不良であった。多変量解析にてpVEGFR-2発現のみが独立した予後因子であった。以上より、VEGFR-2シグナルは膵癌患者の予後と関連すると考えられた。

  • E-cadherin expression might be a predictive marker for chemosensitivity in triple-negative breast cancer Reviewed

    Shinichiro Kashiwagi, Yashiro Masakazu, Takashima Tsutomu, Noda Satoru, Kawajiri Hidemi, Matsuoka Junko, Fuyuhiro Yuhiko, Kato Yukihiro, Doi Yosuke, Kubo Naoshi, Tanaka Hiroaki, Muguruma Kazuya, Inoue Toru, Sawada Tetsuji, Onoda Naoyoshi, Nakata Bunzo, Ohira Masaichi, Ishikawa Tetsuro, Hirakawa Kosei

    CANCER RESEARCH   70   2010.04( ISSN:0008-5472

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    DOI: 10.1158/1538-7445.AM10-2708

  • Identification of HLA-A*0201 and A*2402-restricted epitope peptides derived from mucin 5AC (MUC5AC) gene expressed in human pancreatic cancer as a potential target for immunotherapy Reviewed

    Yamazoe Sadaaki, Tanaka Hiroaki, Iwauchi Takehiko, Noda Eiji, Amano Ryosuke, Kubo Naoshi, Mugurunna Kazuya, Inoue Toru, Takashinna Tsutomu, Yamada Nobuya, Yashiro Masakazu, Maeda Kiyoshi, Onoda Naoyoshi, Sawada Tetsuji, Nakata Bunzo, Ohira Masaichi, Ishikawa Tetsuro, Hirakawa Kosei

    CANCER RESEARCH   70   2010.04( ISSN:0008-5472

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    DOI: 10.1158/1538-7445.AM10-4748

  • OP-091-2 右開胸開腹,胃管再建による胸部食道癌術後合併症におよぼす因子の検討(食道治療-1,一般口演,第110回日本外科学会定期学術集会) Reviewed

    大平 雅一, 田中 浩明, 久保 尚士, 森本 純也, 六車 一哉, 天野 良亮, 野田 英児, 井上 透, 山田 靖哉, 八代 正和, 前田 清, 澤田 鉄二, 山下 好人, 西口 幸雄, 平川 弘聖

    一般社団法人日本外科学会 日本外科学会雑誌   111 ( 2 )   2010.03( ISSN:03014894

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  • OP-268-3 術後胃排泄遅延からみた膵頭十二指腸切除術後消化管再建法の検討(膵・その他,一般口演,第110回日本外科学会定期学術集会) Reviewed

    中本 健太郎, 天野 良亮, 山田 靖哉, 大平 豪, 土井 洋輔, 岩内 武彦, 野田 英児, 久保 尚士, 田中 浩明, 六車 一哉, 井上 透, 高島 勉, 八代 正和, 小野田 尚佳, 前田 清, 澤田 鉄二, 仲田 文造, 大平 雅一, 石川 哲郎, 平川 弘聖

    一般社団法人日本外科学会 日本外科学会雑誌   111 ( 2 )   2010.03( ISSN:03014894

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  • OP-248-2 膵癌に対するS-1+lapatinib併用療法の基礎的検討(膵・集学的-2,一般口演,第110回日本外科学会定期学術集会) Reviewed

    河本 真大, 仲田 文造, 天野 良亮, 野田 英児, 久保 尚士, 田中 浩明, 六車 一哉, 井上 透, 高島 勉, 山田 靖哉, 八代 正和, 前田 清, 小野田 尚佳, 澤田 鉄二, 大平 雅一, 石川 哲郎, 平川 弘聖

    一般社団法人日本外科学会 日本外科学会雑誌   111 ( 2 )   2010.03( ISSN:03014894

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  • OP-206-3 cStageII, III食道癌切除症例におけるリンパ節内微小転移の検出と再発との関連について(食道-2,一般口演,第110回日本外科学会定期学術集会) Reviewed

    森本 純也, 田中 浩明, 久保 尚士, 六車 一哉, 山添 定明, 岩内 武彦, 伊藤 厳太郎, 河本 真大, 永原 央, 天野 良亮, 野田 英児, 井上 透, 山田 靖哉, 八代 正和, 小野田 尚佳, 仲田 文造, 前田 清, 澤田 鉄二, 大平 雅一, 石川 哲郎, 平川 弘聖

    一般社団法人日本外科学会 日本外科学会雑誌   111 ( 2 )   2010.03( ISSN:03014894

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  • OP-201-4 StageIV胃癌に対する外科的手術介入の是非について(Stage IV胃癌-7,一般口演,第110回日本外科学会定期学術集会) Reviewed

    六車 一哉, 澤田 鉄二, 豊川 貴弘, 森本 純也, 野田 英児, 天野 良亮, 久保 尚士, 田中 浩明, 井上 透, 高島 勉, 八代 正和, 山田 靖哉, 山下 好人, 小野田 尚佳, 前田 清, 仲田 文造, 大平 雅一, 石川 哲郎, 平川 弘聖

    一般社団法人日本外科学会 日本外科学会雑誌   111 ( 2 )   2010.03( ISSN:03014894

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  • OP-128-3 トリプルネガティブ乳癌におけるE-cadherin発現と予後リスク(乳癌基礎-4,一般口演,第110回日本外科学会定期学術集会) Reviewed

    柏木 伸一郎, 八代 正和, 高島 勉, 野田 諭, 川尻 成美, 小野田 尚佳, 仲田 文造, 石川 哲郎, 平川 弘聖

    一般社団法人日本外科学会 日本外科学会雑誌   111 ( 2 )   2010.03( ISSN:03014894

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  • OP-123-1 膵癌細胞浸潤能におけるVEGF-A/VEGFR-2シグナルの関与(膵癌-5,一般口演,第110回日本外科学会定期学術集会) Reviewed

    土井 洋輔, 八代 正和, 山田 靖哉, 天野 良亮, 野田 諭, 河本 真大, 六車 一哉, 田中 浩明, 久保 尚士, 井上 透, 野田 英児, 前田 清, 仲田 文造, 澤田 鉄二, 大平 雅一, 平川 弘聖

    一般社団法人日本外科学会 日本外科学会雑誌   111 ( 2 )   2010.03( ISSN:03014894

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  • OP-110-2 膵管内乳頭粘液性腫瘍(IPMN)に対する外科的治療成績と手術適応に関する検討(IPMN,一般口演,第110回日本外科学会定期学術集会) Reviewed

    大平 豪, 山田 靖哉, 天野 良亮, 土井 洋輔, 岩内 武彦, 中本 健太郎, 野田 英児, 久保 尚士, 田中 浩明, 六車 一哉, 高島 勉, 井上 透, 八代 正和, 小野田 尚佳, 前田 清, 澤田 鉄二, 仲田 文造, 大平 雅一, 石川 哲郎, 平川 弘聖

    一般社団法人日本外科学会 日本外科学会雑誌   111 ( 2 )   2010.03( ISSN:03014894

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  • WS-5-7 オクトレオチドによる膵消化管内分泌腫瘍の治療戦略(難治性内分泌癌(甲状腺未分化癌,再発甲状腺分化癌,副腎癌,Neuroendocrine tumor)の治療戦略,ワークショップ(5),第110回日本外科学会定期学術集会) Reviewed

    天野 良亮, 山田 靖哉, 大平 豪, 中本 健太郎, 土井 洋輔, 岩内 武彦, 野田 英児, 久保 尚士, 田中 浩明, 六車 一哉, 井上 透, 高島 勉, 八代 正和, 小野田 尚佳, 前田 清, 澤田 鉄二, 仲田 文造, 大平 雅一, 石川 哲郎, 平川 弘聖

    一般社団法人日本外科学会 日本外科学会雑誌   111 ( 2 )   2010.03( ISSN:03014894

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  • SF-041-3 潰瘍性大腸炎に対する腹腔鏡手術の妥当性および標準化における問題点(鏡視下手術・消化管良性,サージカルフォーラム,第110回日本外科学会定期学術集会) Reviewed

    前田 清, 野田 英児, 井上 透, 永原 央, 八代 正和, 山田 靖哉, 澤田 鉄二, 六車 一哉, 大平 雅一, 久保 尚士, 田中 浩明, 西口 幸雄, 池原 照幸, 平川 弘聖

    一般社団法人日本外科学会 日本外科学会雑誌   111 ( 2 )   2010.03( ISSN:03014894

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  • SF-036-3 癌細胞-線維芽細胞の相互作用における胃癌細胞のビメンチン発現の検討(腫瘍基礎-6,サージカルフォーラム,第110回日本外科学会定期学術集会) Reviewed

    冬廣 雄彦, 八代 正和, 久保 尚士, 田中 浩明, 六車 一哉, 井上 透, 山田 靖哉, 前田 清, 澤田 鉄二, 大平 雅一, 平川 弘聖

    一般社団法人日本外科学会 日本外科学会雑誌   111 ( 2 )   2010.03( ISSN:03014894

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  • SF-010-2 膵癌細胞に高発現するMUC5AC由来HLA-A*0201, A*2402拘束性エピトープペプチドの同定と膵癌に対するペプチドワクチン療法への応用の可能性(免疫-1,サージカルフォーラム,第110回日本外科学会定期学術集会) Reviewed

    山添 定明, 田中 浩明, 岩内 武彦, 森本 純也, 伊藤 厳太郎, 川尻 成美, 野田 英児, 天野 良亮, 久保 尚士, 六車 一哉, 井上 透, 高島 勉, 山田 靖哉, 八代 正和, 前田 清, 小野田 尚佳, 澤田 鉄二, 仲田 文造, 大平 雅一, 石川 哲郎, 平川 弘聖

    一般社団法人日本外科学会 日本外科学会雑誌   111 ( 2 )   2010.03( ISSN:03014894

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  • WS-6-7 胃癌の腹膜播種性転移における低酸素の関与とTGFβR阻害剤の効果(消化器癌腹膜転移の治療:基礎と臨床,ワークショップ(6),第110回日本外科学会定期学術集会) Reviewed

    野田 諭, 八代 正和, 天野 良亮, 野田 英児, 久保 尚士, 田中 浩明, 六車 一哉, 高島 勉, 井上 透, 山田 靖哉, 小野田 尚佳, 前田 清, 澤田 鉄二, 仲田 文造, 大平 雅一, 石川 哲郎, 平川 弘聖

    一般社団法人日本外科学会 日本外科学会雑誌   111 ( 2 )   2010.03( ISSN:03014894

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  • OP-091-2 右開胸開腹,胃管再建による胸部食道癌術後合併症におよぼす因子の検討(食道治療-1,一般口演,第110回日本外科学会定期学術集会) Reviewed

    大平 雅一, 田中 浩明, 久保 尚士, 森本 純也, 六車 一哉, 天野 良亮, 野田 英児, 井上 透, 山田 靖哉, 八代 正和, 前田 清, 澤田 鉄二, 山下 好人, 西口 幸雄, 平川 弘聖

    日本外科学会雑誌   111 ( 2 )   430   2010.03( ISSN:03014894

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  • WS-6-7 胃癌の腹膜播種性転移における低酸素の関与とTGFβR阻害剤の効果(消化器癌腹膜転移の治療:基礎と臨床,ワークショップ(6),第110回日本外科学会定期学術集会) Reviewed

    野田 諭, 八代 正和, 天野 良亮, 野田 英児, 久保 尚士, 田中 浩明, 六車 一哉, 高島 勉, 井上 透, 山田 靖哉, 小野田 尚佳, 前田 清, 澤田 鉄二, 仲田 文造, 大平 雅一, 石川 哲郎, 平川 弘聖

    日本外科学会雑誌   111 ( 2 )   167   2010.03( ISSN:03014894

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  • WS-5-7 オクトレオチドによる膵消化管内分泌腫瘍の治療戦略(難治性内分泌癌(甲状腺未分化癌,再発甲状腺分化癌,副腎癌,Neuroendocrine tumor)の治療戦略,ワークショップ(5),第110回日本外科学会定期学術集会) Reviewed

    天野 良亮, 山田 靖哉, 大平 豪, 中本 健太郎, 土井 洋輔, 岩内 武彦, 野田 英児, 久保 尚士, 田中 浩明, 六車 一哉, 井上 透, 高島 勉, 八代 正和, 小野田 尚佳, 前田 清, 澤田 鉄二, 仲田 文造, 大平 雅一, 石川 哲郎, 平川 弘聖

    日本外科学会雑誌   111 ( 2 )   165   2010.03( ISSN:03014894

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  • SF-041-3 潰瘍性大腸炎に対する腹腔鏡手術の妥当性および標準化における問題点(鏡視下手術・消化管良性,サージカルフォーラム,第110回日本外科学会定期学術集会) Reviewed

    前田 清, 野田 英児, 井上 透, 永原 央, 八代 正和, 山田 靖哉, 澤田 鉄二, 六車 一哉, 大平 雅一, 久保 尚士, 田中 浩明, 西口 幸雄, 池原 照幸, 平川 弘聖

    日本外科学会雑誌   111 ( 2 )   235   2010.03( ISSN:03014894

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  • SF-036-3 癌細胞-線維芽細胞の相互作用における胃癌細胞のビメンチン発現の検討(腫瘍基礎-6,サージカルフォーラム,第110回日本外科学会定期学術集会) Reviewed

    冬廣 雄彦, 八代 正和, 久保 尚士, 田中 浩明, 六車 一哉, 井上 透, 山田 靖哉, 前田 清, 澤田 鉄二, 大平 雅一, 平川 弘聖

    日本外科学会雑誌   111 ( 2 )   229   2010.03( ISSN:03014894

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  • SF-010-2 膵癌細胞に高発現するMUC5AC由来HLA-A*0201, A*2402拘束性エピトープペプチドの同定と膵癌に対するペプチドワクチン療法への応用の可能性(免疫-1,サージカルフォーラム,第110回日本外科学会定期学術集会) Reviewed

    山添 定明, 田中 浩明, 岩内 武彦, 森本 純也, 伊藤 厳太郎, 川尻 成美, 野田 英児, 天野 良亮, 久保 尚士, 六車 一哉, 井上 透, 高島 勉, 山田 靖哉, 八代 正和, 前田 清, 小野田 尚佳, 澤田 鉄二, 仲田 文造, 大平 雅一, 石川 哲郎, 平川 弘聖

    日本外科学会雑誌   111 ( 2 )   196   2010.03( ISSN:03014894

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  • OP-268-3 術後胃排泄遅延からみた膵頭十二指腸切除術後消化管再建法の検討(膵・その他,一般口演,第110回日本外科学会定期学術集会) Reviewed

    中本 健太郎, 天野 良亮, 山田 靖哉, 大平 豪, 土井 洋輔, 岩内 武彦, 野田 英児, 久保 尚士, 田中 浩明, 六車 一哉, 井上 透, 高島 勉, 八代 正和, 小野田 尚佳, 前田 清, 澤田 鉄二, 仲田 文造, 大平 雅一, 石川 哲郎, 平川 弘聖

    日本外科学会雑誌   111 ( 2 )   701   2010.03( ISSN:03014894

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  • OP-248-2 膵癌に対するS-1+lapatinib併用療法の基礎的検討(膵・集学的-2,一般口演,第110回日本外科学会定期学術集会) Reviewed

    河本 真大, 仲田 文造, 天野 良亮, 野田 英児, 久保 尚士, 田中 浩明, 六車 一哉, 井上 透, 高島 勉, 山田 靖哉, 八代 正和, 前田 清, 小野田 尚佳, 澤田 鉄二, 大平 雅一, 石川 哲郎, 平川 弘聖

    日本外科学会雑誌   111 ( 2 )   668   2010.03( ISSN:03014894

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  • OP-206-3 cStageII, III食道癌切除症例におけるリンパ節内微小転移の検出と再発との関連について(食道-2,一般口演,第110回日本外科学会定期学術集会) Reviewed

    森本 純也, 田中 浩明, 久保 尚士, 六車 一哉, 山添 定明, 岩内 武彦, 伊藤 厳太郎, 河本 真大, 永原 央, 天野 良亮, 野田 英児, 井上 透, 山田 靖哉, 八代 正和, 小野田 尚佳, 仲田 文造, 前田 清, 澤田 鉄二, 大平 雅一, 石川 哲郎, 平川 弘聖

    日本外科学会雑誌   111 ( 2 )   602   2010.03( ISSN:03014894

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  • OP-201-4 StageIV胃癌に対する外科的手術介入の是非について(Stage IV胃癌-7,一般口演,第110回日本外科学会定期学術集会) Reviewed

    六車 一哉, 澤田 鉄二, 豊川 貴弘, 森本 純也, 野田 英児, 天野 良亮, 久保 尚士, 田中 浩明, 井上 透, 高島 勉, 八代 正和, 山田 靖哉, 山下 好人, 小野田 尚佳, 前田 清, 仲田 文造, 大平 雅一, 石川 哲郎, 平川 弘聖

    日本外科学会雑誌   111 ( 2 )   595   2010.03( ISSN:03014894

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  • OP-128-3 トリプルネガティブ乳癌におけるE-cadherin発現と予後リスク(乳癌基礎-4,一般口演,第110回日本外科学会定期学術集会) Reviewed

    柏木 伸一郎, 八代 正和, 高島 勉, 野田 諭, 川尻 成美, 小野田 尚佳, 仲田 文造, 石川 哲郎, 平川 弘聖

    日本外科学会雑誌   111 ( 2 )   491   2010.03( ISSN:03014894

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  • OP-123-1 膵癌細胞浸潤能におけるVEGF-A/VEGFR-2シグナルの関与(膵癌-5,一般口演,第110回日本外科学会定期学術集会) Reviewed

    土井 洋輔, 八代 正和, 山田 靖哉, 天野 良亮, 野田 諭, 河本 真大, 六車 一哉, 田中 浩明, 久保 尚士, 井上 透, 野田 英児, 前田 清, 仲田 文造, 澤田 鉄二, 大平 雅一, 平川 弘聖

    日本外科学会雑誌   111 ( 2 )   482   2010.03( ISSN:03014894

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  • OP-110-2 膵管内乳頭粘液性腫瘍(IPMN)に対する外科的治療成績と手術適応に関する検討(IPMN,一般口演,第110回日本外科学会定期学術集会) Reviewed

    大平 豪, 山田 靖哉, 天野 良亮, 土井 洋輔, 岩内 武彦, 中本 健太郎, 野田 英児, 久保 尚士, 田中 浩明, 六車 一哉, 高島 勉, 井上 透, 八代 正和, 小野田 尚佳, 前田 清, 澤田 鉄二, 仲田 文造, 大平 雅一, 石川 哲郎, 平川 弘聖

    日本外科学会雑誌   111 ( 2 )   460   2010.03( ISSN:03014894

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  • Inhibitory effect of a TGF beta receptor type-I inhibitor, Ki26894, on invasiveness of scirrhous gastric cancer cells Reviewed

    Shinto O., Yashiro M., Kawajiri H., Shimizu K., Shimizu T., Miwa A., Hirakawa K.

    BRITISH JOURNAL OF CANCER   102 ( 5 )   844 - 851   2010.03( ISSN:0007-0920

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    DOI: 10.1038/sj.bjc.6605561

  • Establishment and characterization of a new hypoxia-resistant cancer cell line, OCUM-12/Hypo, derived from a scirrhous gastric carcinoma Reviewed

    Kato Y., Yashiro M., Noda S., Tendo M., Kashiwagi S., Doi Y., Nishii T., Matsuoka J., Fuyuhiro Y., Shinto O., Sawada T., Ohira M., Hirakawa K.

    BRITISH JOURNAL OF CANCER   102 ( 5 )   898 - 907   2010.03( ISSN:0007-0920

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    DOI: 10.1038/sj.bjc.6605543

  • Establishment and characterization of a new hypoxia-resistant cancer cell line, OCUM-12/Hypo, derived from a scirrhous gastric carcinoma. Reviewed

    Kato Y, Yashiro M, Noda S, Tendo M, Kashiwagi S, Doi Y, Nishii T, Matsuoka J, Fuyuhiro Y, Shinto O, Sawada T, Ohira M, Hirakawa K

    British journal of cancer   102 ( 5 )   898 - 907   2010.03( ISSN:0007-0920

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    DOI: 10.1038/sj.bjc.6605543

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  • Inhibitory effect of a TGFbeta receptor type-I inhibitor, Ki26894, on invasiveness of scirrhous gastric cancer cells. Reviewed

    Shinto O, Yashiro M, Kawajiri H, Shimizu K, Shimizu T, Miwa A, Hirakawa K

    British journal of cancer   102 ( 5 )   844 - 51   2010.03( ISSN:0007-0920

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    DOI: 10.1038/sj.bjc.6605561

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  • Hypoxia upregulates adhesion ability to peritoneum through a transforming growth factor-beta-dependent mechanism in diffuse-type gastric cancer cells Reviewed

    Noda Satoru, Yashiro Masakazu, Nshii Takafumi, Hirakawa Kosei

    EUROPEAN JOURNAL OF CANCER   46 ( 5 )   995 - 1005   2010.03( ISSN:0959-8049

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    DOI: 10.1016/j.ejca.2010.01.007

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  • Establishment and characterization of multidrug-resistant gastric cancer cell lines. Reviewed

    Zhang X, Yashiro M, Qiu H, Nishii T, Matsuzaki T, Hirakawa K

    Anticancer research   30 ( 3 )   915 - 21   2010.03( ISSN:0250-7005

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  • Establishment and Characterization of Multidrug-resistant Gastric Cancer Cell Lines Reviewed

    Zhang Xiaotian, Yashiro Masakazu, Qiu Hong, Nishii Takafumi, Matsuzaki Taro, Hirakawa Kosei

    ANTICANCER RESEARCH   30 ( 3 )   915 - 921   2010.03( ISSN:0250-7005

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  • Establishment and Characterization of Multidrug-resistant Gastric Cancer Cell Lines Reviewed

    Xiaotian Zhang, Masakazu Yashiro, Hong Qiu, Takafumi Nishii, Taro Matsuzaki, Kosei Hirakawa

    ANTICANCER RESEARCH   30 ( 3 )   915 - 921   2010.03( ISSN:0250-7005

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    Aim: The aim of this study was to establish drug-resistant cell lines and to elucidate mechanisms leading to multi-drug resistance in gastric cancer. Materials and Methods: Five cancer cell lines resistant to 5-fluorouracil, paclitaxel, oxaliplatin, irinotecan, or gemcitabine, were respectively established from a parent gastric cancer cell line, OCUM-2M, by stepwise exposure to each chemotherapeutical agent. Results: Cell death by apoptosis induced by anti-cancer drugs was low in 5 chemo-resistant cell lines. Percentage of cells in S and G(0)/G(1) phase was low in cell lines resistant to oxaliplatin or irinotecan. Cell lines resistant to paclitaxel, oxaliplatin, and gemcitabine showed multi-drug resistance. Alterations in MRP, DAPK1, or DAPK2 expression were found in multi-drug resistant cell lines. Conclusion: The cell-cycle distribution and alterations of MRP, DAPK1, and DAPK2 genes may be integral part of mechanisms responsible for chemo-resistance. These cell lines might be useful to study molecular mechanisms leading to multi-drug resistance.

    PubMed

  • Hypoxia upregulates adhesion ability to peritoneum through a transforming growth factor-beta-dependent mechanism in diffuse-type gastric cancer cells Reviewed

    Satoru Noda, Masakazu Yashiro, Takafumi Nshii, Kosei Hirakawa

    EUROPEAN JOURNAL OF CANCER   46 ( 5 )   995 - 1005   2010.03( ISSN:0959-8049

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    Gastric cancer cells leaving the primary tumour are exposed to low oxygen levels in the peritoneal cavity; however, peritoneal metastatic phenotypes of hypoxic cancer cells remain unclear. We used 6 gastric cancer cell lines, including 3 diffuse-type gastric cancer (DGC) and 3 non-DGC cell lines. Using adhesion assay, we examined the effect of hypoxic conditions on their ability to adhere to peritoneal components. The expression level of transforming growth factor-beta (TGF-beta) and integrins mRNA of cancer cells was examined using reverse transcriptase-polymerase chain reaction. We further examined the effect of anti-integrin neutralising antibodies and a TGF-beta receptor inhibitor on the adhesion ability of hypoxic cancer cells. The binding ability of DGC cells was higher than that of non-DGC cells; it was significantly increased by hypoxic (1% O(2)) conditions compared to normoxic (21% O(2)) conditions. In contrast, no remarkable change in adhesion ability was observed in the non-DGC cells under normoxic and hypoxic conditions. Integrins and TGF-beta expression of hypoxic DGC cells was significantly higher than that of normoxic cells. TGF-beta increased the adhesion ability and alpha 2-, alpha 3- and alpha 5-integrin expression of hypoxic DGC cells, whereas the TGF-beta receptor inhibitor decreased them. Neutralising antibodies against alpha 2-, alpha 3- and alpha 5-integrin inhibited the adhesion ability of DGC cells. These findings suggested that hypoxic conditions promote the adhesion of DGC cells to the peritoneum. The upregulation of alpha 2-, alpha 3- and alpha 5-integrin by TGF-beta under hypoxic conditions may be one of the mechanisms responsible for the high metastatic potential of hypoxic DGC cells to the peritoneum. (C) 2010 Elsevier Ltd. All rights reserved.

    DOI: 10.1016/j.ejca.2010.01.007

    PubMed

  • Establishment and characterization of multidrug-resistant gastric cancer cell lines. Reviewed

    Zhang X, Yashiro M, Qiu H, Nishii T, Matsuzaki T, Hirakawa K

    Anticancer research   30 ( 3 )   915 - 21   2010.03( ISSN:0250-7005

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  • Synergistic antitumor effects of FGFR2 inhibitor with 5-fluorouracil on scirrhous gastric carcinoma Reviewed

    Yashiro Masakazu, Shinto Osamu, Nakamura Kazunori, Tendo Masashige, Matsuoka Tasuku, Matsuzaki Taro, Kaizaki Ryoji, Miwa Atsushi, Hirakawa Kosei

    INTERNATIONAL JOURNAL OF CANCER   126 ( 4 )   1004 - 1016   2010.02( ISSN:0020-7136

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    DOI: 10.1002/ijc.24763

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  • Synergistic antitumor effects of FGFR2 inhibitor with 5-fluorouracil on scirrhous gastric carcinoma Reviewed

    Masakazu Yashiro, Osamu Shinto, Kazunori Nakamura, Masashige Tendo, Tasuku Matsuoka, Taro Matsuzaki, Ryoji Kaizaki, Atsushi Miwa, Kosei Hirakawa

    INTERNATIONAL JOURNAL OF CANCER   126 ( 4 )   1004 - 16   2010.02( ISSN:0020-7136

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    Scirrhous gastric carcinoma (SGC) carries the highest mortality because of a frequent metastasis to lymph node (LN). S1, a 5-fluorouracil (5-FU) analog, is clinically available for gastric cancer at an advanced stage. Fibroblast growth factor receptor 2 (FGFR2) is required for the proliferation of SGC. The objective of this study is to clarify the benefit of a combination of S1 and kinase inhibitors including FGFR2 inhibitor Ki23057 in gastric cancer. OCUM-2MLN and KATO-III were derived from SGC. MKN-7 and MKN-74 were derived from non-SGC. MTT assay was used to examine the growth-inhibitory activity of 5 small-synthetic molecules including Ki23057, Sunitinib, Glivec, Lapatinib or SU11274, in cells cultured with 5-FU. Combination effects of 5-FU with Ki23057 on proliferation, apoptosis and mRNA expression were examined. S1 and/or Ki23057 were administered to murine models of SGC created by the orthotopic inoculation of OCUM-2MLN cells. Ki23057 at 100 nM significantly (P &lt; 0.01) inhibited the proliferation and decreased the phosphorylation of FGFR2 in SGC cells, but not in non-SGC. Ki23057 showed synergistic antitumor effects for SGC cells in combination with 5-FU using CalcuSyn analysis, but Sunitinib, Glivec, Lapatinib and SU11274 did not. The combination of Ki23057 and 5-FU decreased DPD expression and increased apoptosis rates and p21 expression level of SGC cells. The combined administration of S1 and Ki23057 significantly (p &lt; 0.05) decreased orthotopic tumors as well as LN metastasis more effectively than S1 atone. These findings suggested that the combined treatment with 5-FU and Ki23057 produced synergistic antitumor effects and is therapeutically promising for SGC treatment.

    DOI: 10.1002/ijc.24763

    PubMed

  • In vitro and in vivo evidence that a combination of lapatinib plus S-1 is a promising treatment for pancreatic cancer Reviewed

    KOMOTO Masahiro, NAKATA Bunzo, NISHII Takafumi, KAWAJIRI Hidemi, SHINTO Osamu, AMANO Ryosuke, YAMADA Nobuya, YASHIRO Masakazu, HIRAKAWA Kosei

    Cancer science   101 ( 2 )   468 - 473   2010.02( ISSN:13479032

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  • In vitro and in vivo evidence that a combination of lapatinib plus S-1 is a promising treatment for pancreatic cancer Reviewed

    KOMOTO Masahiro, NAKATA Bunzo, NISHII Takafumi, KAWAJIRI Hidemi, SHINTO Osamu, AMANO Ryosuke, YAMADA Nobuya, YASHIRO Masakazu, HIRAKAWA Kosei

    101 ( 2 )   468 - 473   2010.02( ISSN:13479032

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  • In vitro and in vivo evidence that a combination of lapatinib plus S-1 is a promising treatment for pancreatic cancer Reviewed

    Komoto Masahiro, Nakata Bunzo, Nishii Takafumi, Kawajiri Hidemi, Shinto Osamu, Amano Ryosuke, Yamada Nobuya, Yashiro Masakazu, Hirakawa Kosei

    CANCER SCIENCE   101 ( 2 )   468 - 473   2010.02( ISSN:1349-7006

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    DOI: 10.1111/j.1349-7006.2009.01405.x

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  • In vitro and in vivo evidence that a combination of lapatinib plus S-1 is a promising treatment for pancreatic cancer Reviewed

    Masahiro Komoto, Bunzo Nakata, Takafumi Nishii, Hidemi Kawajiri, Osamu Shinto, Ryosuke Amano, Nobuya Yamada, Masakazu Yashiro, Kosei Hirakawa

    CANCER SCIENCE   101 ( 2 )   468 - 73   2010.02( ISSN:1347-9032

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    Lapatinib is a small molecule inhibitor of both HER2 and the epidermal growth factor receptor ( EGFR). We investigated the effect of treatment with lapatinib alone or in combination with a fluoropyrimidine derivative S-1 against pancreatic cancer. The HER2/EGFR expression in each of the four pancreatic cancer cell lines MiaPaca-2, PANC-1, Capan-1 and Capan-2 was measured by flow cytometry. The anti-tumor effects of lapatinib (30 mg/kg) and/or S-1 (10 mg/kg) were evaluated using female BALB/c nude mice xenografts generated using these four cell lines. Synergy between lapatinib and S-1 was examined by median effect analysis in vitro. Resected pancreatic cancer tissues from 137 patients were immunohistochemically stained with anti-human HER2 and EGFR antibodies. The administration of lapatinib as a single agent substantially suppressed tumor growth in vivo of all pancreatic cancer cell lines examined. A strong correlation was observed between HER2 expression and the anti-tumor effect of lapatinib in vivo. Lapatinib synergized with S-1 to inhibit the tumor growth of MiaPaca-2 and PANC-1 xenografts. When used as a single agent in vitro, lapatinib barely inhibit the cell growth of any cell line. However, lapatinib synergized with the anti-tumor activity of the S-1 components 5-fluorouracil and 5-chloro-2,4-dihydrogenase against all cell lines. Immunohistochemical staining demonstrated that 70% of the pancreatic cancers overexpressed HER2 and/or EGFR. Both lapatinib monotherapy and combined treatment with S-1 may be promising treatments for patients with pancreatic cancers; the majority these cancers express lapatinib target molecules. (Cancer Sci 2010; 101: 468-473)

    DOI: 10.1111/j.1349-7006.2009.01405.x

    PubMed

  • ラパニチブとS-1の併用が膵癌に対する有望な治療であることを示すin vitroおよびin vivoの根拠(In vitro and in vivo evidence that a combination of lapatinib plus S-1 is a promising treatment for pancreatic cancer) Reviewed

    Komoto Masahiro, Nakata Bunzo, Nishii Takafumi, Kawajiri Hidemi, Shinto Osamu, Amano Ryosuke, Yamada Nobuya, Yashiro Masakazu, Hirakawa Kosei

    Cancer Science   101 ( 2 )   468 - 473   2010.02( ISSN:1347-9032

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    ヌードマウスに移植した膵癌細胞株MiaPaca-2、PANC-1、Capan-1およびCapan-2に対するHER2およびEGFRの阻害剤ラパチニブとフルオロピリミジン誘導体S-1の併用効果を調べた。細胞株のHER2発現とラパチニブの抗腫瘍効果は相関した。MiaPaca-2およびPANC-1移植腫瘍に対してラパチニブとS-1の相乗効果が認められた。ラパチニブ単独ではin vitro細胞増殖を殆ど抑制しなかったが、S-1成分である5-FUとCDHPの抗腫瘍活性と相乗効果を示した。膵癌患者137名の腫瘍組織の免疫組織化学染色にて70%の膵癌がHER2および/またはEGFRを高発現していた。膵癌ではラパチニブの標的分子を発現する頻度が高いことから、ラパチニブ単独またはS-1との併用は膵癌患者の治療法として有望である。

  • Cancer-stromal interactions in scirrhous gastric carcinoma. Reviewed

    Yashiro M, Hirakawa K

    Cancer microenvironment : official journal of the International Cancer Microenvironment Society   3 ( 1 )   127 - 35   2010.01( ISSN:1875-2292

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    DOI: 10.1007/s12307-010-0036-5

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  • Myofibroblasts are associated with the progression of scirrhous gastric carcinoma Reviewed

    Fuyuhiro Yuhiko, Yashiro Masakazu, Noda Satoru, Kashiwagi Shinichiro, Matsuoka Junko, Doi Yosuke, Kato Yukihiro, Muguruma Kazuya, Sawada Tetsuji, Hirakawa Kosei

    EXPERIMENTAL AND THERAPEUTIC MEDICINE   1 ( 4 )   547 - 551   2010( ISSN:1792-0981

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    DOI: 10.3892/etm_00000086

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  • Expression of a Hypoxia-Associated Protein, Carbonic Anhydrase-9, Correlates with Malignant Phenotypes of Gastric Carcinoma Reviewed

    Kato Yukihiro, Yashiro Masakazu, Noda Satoru, Kashiwagi Shinichiro, Matsuoka Junko, Fuyuhiro Yuhiko, Doi Yosuke, Hirakawa Kosei

    DIGESTION   82 ( 4 )   246 - 251   2010( ISSN:0012-2823

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    DOI: 10.1159/000297208

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  • Reduction of E-cadherin expression is correlated with prognosis in triple-negative breast cancer Reviewed

    Kashiwagi Shinichiro, Yashiro Masakazu, Takashima Tsutomu, Noda Satoru, Kawajiri Hidemi, Onoda Naoyoshi, Ishikawa Tetsuro, Hirakawa Kosei

    Japanese Society for Molecular Tumor Marker Research, Japan Journal of Molecular Tumor Marker Research   ( 25 )   65 - 65   2010

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    DOI: 10.11241/jsmtmr.25.65

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  • Docetaxel with concurrent radiotherapy in patients with inoperable or relapsed oesophageal cancer Reviewed

    Naoshi Kubo, Jyunya Morimoto, Katsunobu Sakurai, Hiroaki Tanaka, Kazuya Muguruma, Ryosuke Amano, Eiji Noda, Hisashi Nagahara, Tsutomu Takashima, Masakazu Yashiro, Nobuya Yamada, Naoyoshi Onoda, Kiyoshi Maeda, Tetsuji Sawada, Bunzo Nakata, Masaichi Ohira, Tetsuro Ishikawa, Kosei Hirakawa

    Japanese Journal of Cancer and Chemotherapy   37 ( 12 )   2261 - 2263   2010( ISSN:0385-0684

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    In vivo studies have shown docetaxel, a new chemotherapeutic agent, enhances radio-sensitivity by causing a cell cycle arrest in the G2/M phase. We report here to evaluate the efficacy and tolerability of weekly docetaxel concurrent with radiotherapy in advanced or relapsed oesophageal cancer patients. Material and methods: A total of 8 esophageal cancer patients with relapsed mediastinal lymph nodes (6 patients), psychological disease (1 patient) and local advanced tumor (cT4) after initial 5-FU/CDDP therapy (1 patients) received docetaxel (10mg/m2 weekly) plus concurrent radiotherapy (2 Gy daily, a total dose of 60 Gy). Results: 2 patients achieved a complete response and 5 patients achieved a partial response, for an overall response rate of 87.5%. Median survival length was 13.3 months and time to disease progression was 6.6 months. No patient experienced grade 3-4 hematological adverse event. There was esophago-medi-astinal fistula in 1 patient. Conclusions: Docetaxel with concurrent radiotherapy was very effective for relapsed or local advanced esophageal cancer. This therapy had no high grade adverse event and a quality of life in esophageal cancer patients could be maintained.

    PubMed

  • Expression of a Hypoxia-Associated Protein, Carbonic Anhydrase-9, Correlates with Malignant Phenotypes of Gastric Carcinoma Reviewed

    Yukihiro Kato, Masakazu Yashiro, Satoru Noda, Shinichiro Kashiwagi, Junko Matsuoka, Yuhiko Fuyuhiro, Yosuke Doi, Kosei Hirakawa

    DIGESTION   82 ( 4 )   246 - 51   2010( ISSN:0012-2823

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    Background/Aims: Gastric cancers are characterized by a heterogeneously hypoxic environment. Hypoxia might stimulate the malignant potential of cancer cells. The purpose of our study was to clarify the significance of hypoxia in gastric carcinoma by evaluating the expression of a hypoxic marker, namely carbonic anhydrase-9 (CA-9). Methods: A total of 265 patients who had undergone a resection of the primary tumor and were confirmed histologically to have sporadic gastric cancer were enrolled in this study. We evaluated the immunohistochemical expression of CA-9 in the paraffin-embedded specimens of 265 gastric adenocarcinomas. Results: The CA-9 expression was positive in 88 (33%) of 265 gastric carcinomas. The CA-9 expression level was significantly high in cases of type 4 carcinoma (60%, p &lt; 0.001) and diffuse type carcinoma (41%, p &lt; 0.001), and significantly correlated with the invasion depth (p &lt; 0.001), lymph node metastasis (p &lt; 0.001) and lymphatic invasion (p = 0.002). The prognosis for CA-9-positive patients was significantly poorer than that of CA-9-negative patients (p = 0.003, log-rank). Conclusion: Hypoxia might be associated with aggressive tumor phenotypes of gastric carcinomas. The hypoxic marker CA-9 may be a useful prognostic indicator. Copyright (c) 2010 S. Karger AG, Basel

    DOI: 10.1159/000297208

    PubMed

  • A case of type 4 gastric cancer with positive peritoneal lavage cytology, which relapsed at the peritoneum at the time of seven years and eight months after resection Reviewed

    Masanori Nakamura, Naoshi Kubo, Junya Morimoto, Hiroaki Tanaka, Kazuya Muguruma, Ryosuke Amano, Eiji Noda, Toru Inoue, Tsutomu Takashima, Nobuya Yamada, Masakazu Yashiro, Yoshito Yamashita, Kiyoshi Maeda, Naoyoshi Onoda, Tetsuji Sawada, Bunzo Nakata, Masaichi Ohira, Tetsurou Ishikawa, Kosei Hirakawa

    Japanese Journal of Cancer and Chemotherapy   37 ( 12 )   2436 - 2438   2010( ISSN:0385-0684

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    A 55-year-old woman was admitted to our hospital with a complaint of appetite loss and body weight loss. Upper digestive endoscopy showed a giant fold at the greater curvature stomach and diffused edematous gastric mucosa. Abdominal contrast CT demonstrated a significant thickening of the gastric wall and a large number of lymphnode swelling. A clinical finding was Stage IIIB (T3N2M0) Type 4 gastric cancer of poorly differentiated adenocarcinoma. Total gastrectomy, splenectomy and D2 lymph node dissection were performed. Although there was no peritoneal dissemination, peritoneal lavage cytology was positive. After the operation, S-1 alone chemotherapy was administered for four years. No recurrence had occurred for about seven years and eight months after resection. However, the patient was pointed out the signs of recurrence (ascites and induration) by CT. Now, S-1 alone chemotherapy was performed again, and the patient has been in good health.

    PubMed

  • Reduction of E-cadherin expression is correlated with prognosis in triple-negative breast cancer Reviewed

    Kashiwagi Shinichiro, Yashiro Masakazu, Takashima Tsutomu, Noda Satoru, Kawajiri Hidemi, Onoda Naoyoshi, Ishikawa Tetsuro, Hirakawa Kosei

    Japan Journal of Molecular Tumor Marker Research   25   65 - 65   2010( eISSN:24338575

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    DOI: 10.11241/jsmtmr.25.65

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  • スキルス胃癌 Reviewed

    八代 正和

    消化器の臨床 13(3)   233 - 239   2010

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  • Two cases of the primary small intestine cancer successfully treated with S-1 and UFT/LV therapy Reviewed

    Tomohiro Lee, Eiji Noda, Kiyoshi Maeda, Toru Inoue, Hisashi Nagahara, Ryosuke Amano, Naoshi Kubo, Hiroaki Tanaka, Kazuya Muguruma, Tsutomu Takashima, Nobuya Yamada, Masakazu Yashiro, Naoyoshi Onoda, Tetsuji Sawada, Bunzo Nakata, Masaichi Ohira, Tetsuro Ishikawa, Kosei Hirakawa

    Japanese Journal of Cancer and Chemotherapy   37 ( 12 )   2789 - 2791   2010( ISSN:0385-0684

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    The primary small intestinal cancer is rare in gastrointestinal cancer, and there are much advanced/recurrent cases. However, there were a few case reports about chemotherapy for advanced or recurrent small intestinal cancer, and a treatment resume was inconsistent. We reported that S-1 and UFT/LV therapy was effective with the two cases as an oral chemotherapy for the primary small intestinal cancer.

    PubMed

  • Two cases of lymph node recurrence after endoscopic mucosal resection of esophageal cancer Reviewed

    Junya Morimoto, Naoshi Kubo, Hiroaki Tanaka, Masaichi Ohira, Kazuya Muguruma, Tetsuji Sawada, Nobuya Yamada, Masakazu Yashiro, Yoshito Yamashita, Yukio Nishiguchi, Kosei Hirakawa

    Japanese Journal of Cancer and Chemotherapy   37 ( 12 )   2379 - 2381   2010( ISSN:0385-0684

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    Here, we reported two cases of lymph node recurrence after endoscopic mucosal resection of esophageal cancer. Case 1: A patient was a 49-year-old man. Endoscopic mucosal resection (EMR) was performed to the 0-IIc type esophageal cancer in October 2005. The pathological findings were moderately differentiated squamous cell carcinoma, pT1b-SM3, lyO, and vO. Therefore, additional therapy of definitive chemoradiation was conducted. However, he complained a difficulty in swallowing in June 2007 and computed tomography (CT) revealed a lymph node measuring 4 cm in diameter at the right side of cardia (#1). Therefore, a radical operation to the lymph node recurrence was performed in August 2007. Pathological findings revealed metastases of cancer were not only in #1 LN but also in #8a. Unfortunately, the patient died on the 37th day after the operation due to a respiratory failure and anastomotic leakage. Case 2: A patient was a 68-year-old man. EMR was performed to the 0-IIa type esophageal cancer in August 2006. The pathological findings were poorly differentiated squamous cell carcinoma, pT1a-MM, lyO, vO. Therefore, adjuvant chemotherapy was added. However, in February 2009, a follow-up CT showed a metastatic lymph node measuring 2 cm in diameter at the right side of cardia (#1) and a radical operation was performed in June 2009. Pathological findings revealed the metastatic lymph nodes were at the right side of cardia (#1) and middle thoracic paraesophagus (#108).

    PubMed

  • The outcome of chemotherapy by sorafenib in advanced hepatocellular carcinoma Reviewed

    Ryosuke Amano, Nobuya Yamada, Eiji Noda, Naoshi Kubo, Hiroaki Tanaka, Kazuya Muguruma, Tsutomu Takashima, Masakazu Yashiro, Kiyoshi Maeda, Naoyoshi Onoda, Tetsuji Sawada, Bunzo Nakata, Masaichi Ohira, Tetsuro Ishikawa, Kosei Hirakawa

    Japanese Journal of Cancer and Chemotherapy   37 ( 12 )   2676 - 2678   2010( ISSN:0385-0684

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    We analyzed the treatment outcome and effect of sorafenib in advanced hepatocellular carcinoma, Nine patients were received the therapy of sorafenib between June 2009 and October 2009. The overall incidence of treatment-related adverse events was 87.5%. Grade 3 drug-related adverse events included a hand-foot skin reaction (two patients) and fatigue (one patient). Grade 2 hypertension (three patients), grade 1 diarrhea (two patients) and anorexia (four patients) occurred at this study. The response rate was 0% (CR/PR 0, SD 2, PD 6) and median overall survival length was 101 days. Now there are two patients undergoing the therapy of sorafenib. Effect of sorafenib in advanced hepatocellular carcinoma was not good in this study, and drug-related adverse events had a high rate. However, the continuous treatment was possible with dose modified chemotherapy.

    PubMed

  • 未分化胃癌(sig、 por)の特性と自然史 Reviewed

    八代 正和

    外科治療 103(4)   325 - 332   2010

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  • 胃癌:転移の臨床病理学的特徴 Reviewed

    八代 正和

    細胞工学 別冊   32 - 38   2010

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  • Synergistic antiproliferative effect of mTOR inhibitors in combination with 5-fluorouracil in scirrhous gastric cancer Reviewed

    MATSUZAKI Taro, YASHIRO Masakazu, KAIZAKI Ryoji, YASUDA Koichi, DOI Yosuke, SAWADA Tetsuji, OHIRA Masaichi, HIRAKAWA Kosei

    Cancer science   100 ( 12 )   2402 - 2410   2009.12( ISSN:13479032

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  • Synergistic antiproliferative effect of mTOR inhibitors in combination with 5-fluorouracil in scirrhous gastric cancer Reviewed

    MATSUZAKI Taro, YASHIRO Masakazu, KAIZAKI Ryoji, YASUDA Koichi, DOI Yosuke, SAWADA Tetsuji, OHIRA Masaichi, HIRAKAWA Kosei

    100 ( 12 )   2402 - 2410   2009.12( ISSN:13479032

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  • Synergistic antiproliferative effect of mTOR inhibitors in combination with 5-fluorouracil in scirrhous gastric cancer Reviewed

    Matsuzaki Taro, Yashiro Masakazu, Kaizaki Ryoji, Yasuda Koichi, Doi Yosuke, Sawada Tetsuji, Ohira Masaichi, Hirakawa Kosei

    CANCER SCIENCE   100 ( 12 )   2402 - 2410   2009.12( ISSN:1349-7006

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    DOI: 10.1111/j.1349-7006.2009.01315.x

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  • Synergistic antiproliferative effect of mTOR inhibitors in combination with 5-fluorouracil in scirrhous gastric cancer Reviewed

    Taro Matsuzaki, Masakazu Yashiro, Ryoji Kaizaki, Koichi Yasuda, Yosuke Doi, Tetsuji Sawada, Masaichi Ohira, Kosei Hirakawa

    CANCER SCIENCE   100 ( 12 )   2402 - 10   2009.12( ISSN:1347-9032

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    The aim of this study is to clarify the benefit of combination chemotherapy in gastric cancer based on a cell-signal inhibitor and an anticancer drug. Two scirrhous gastric cancer cell lines and two non-scirrhous gastric cancer cell lines were used. Five anticancer drugs (5-fluorouracil [5FU], paclitaxel, oxaliplatin, irinotecan, and gemcitabine) and four cell-signal inhibitors, mammalian target of rapamycin (mTOR) inhibitor, glycogen synthase kinase 3 beta, p38 alpha beta MAPK, and cyclin-dependent kinase, were used. The proliferation of cancer cells was examined by MTT assay and in vivo study. The apoptosis of cancer cells and the expression of apoptosis-related molecules were examined by flow cytometry, real-time PCR, and immunostaining. mTOR inhibitors with 5FU showed a synergistic antiproliferative effect in scirrhous gastric cancer, whereas the other signal inhibitors showed no synergistic effect with any anticancer drugs. mTOR inhibitor decreased the IC(50) of 5FU and increased the apoptosis rate in scirrhous gastric cancer cells, but not in non-scirrhous gastric cancer cells. The pan-caspase inhibitor, zVAD-fmk, inhibits apoptosis induced in combination with 5FU and mTOR inhibitor. mTOR inhibitor decreased dihydropyrimidine dehydrogenase, thymidylatesynthase, and bcl-2expression, and increased caspase-3 and p21 expression of scirrhous gastric cancer cells, but did not affect those of non-scirrhous gastric cancer cells. In an in vivo study, mTOR inhibitor significantly enhanced the therapeutic efficacy of S1, an analog of 5FU. These findings suggest that mTOR inhibitor interacts with 5FU in a synergistic manner in scirrhous gastric cancer cells by the activation of the apoptosis signal. Therefore, mTOR inhibitor is a promising therapeutic agent in combination with 5FU in scirrhous gastric cancer. (Cancer Sci 2009; 100: 2402-2410).

    DOI: 10.1111/j.1349-7006.2009.01315.x

    PubMed

  • [A case of advanced esophageal cancer with para-aortic lymph node metastasis with complete response (CR) to combination chemotherapy including nedaplatin]. Reviewed

    Noda S, Kubo N, Tanaka H, Muguruma K, Yashiro M, Yamada N, Maeda K, Sawada T, Ohira M, Ishikawa T, Hirakawa K

    Gan to kagaku ryoho. Cancer & chemotherapy   36 ( 12 )   2451 - 3   2009.11( ISSN:0385-0684

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  • [Results of neo-adjuvant chemotherapy by FOLFOX and FOLFIRI for colorectal liver metastasis]. Reviewed

    Amano R, Yamada N, Noda E, Kubo N, Tanaka H, Muguruma K, Inoue T, Yashiro M, Maeda K, Onoda N, Sawada T, Nakata B, Ohira M, Ishikawa T, Hirakawa K

    Gan to kagaku ryoho. Cancer & chemotherapy   36 ( 12 )   2003 - 5   2009.11( ISSN:0385-0684

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  • [Impacts of PSK and TbetaR inhibitor on immune response in immunosuppressive status associated with cancer]. Reviewed

    Tanaka H, Yamazoe S, Iwauchi T, Kubo N, Muguruma K, Yashiro M, Yamada N, Sawada T, Ohira M, Hirakawa K

    Gan to kagaku ryoho. Cancer & chemotherapy   36 ( 12 )   1969 - 71   2009.11( ISSN:0385-0684

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  • [Concurrent chemoradiotherapy with nedaplatin and 5-fluorouracil (5-fu) for locally advanced squamous cell carcinoma of the esophagus]. Reviewed

    Kubo N, Morimoto J, Tanaka H, Ohira M, Noda E, Amano R, Inoue T, Yamada N, Yashiro M, Maeda K, Yamashita Y, Muguruma K, Sawada T, Hirakawa K

    Gan to kagaku ryoho. Cancer & chemotherapy   36 ( 12 )   1997 - 9   2009.11( ISSN:0385-0684

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  • [A case of stage IV advanced esophageal cancer with a long term survival by radiation therapy combined with nedaplatin and 5-FU chemotherapy]. Reviewed

    Morimoto J, Oohira M, Kubo N, Tanaka H, Dan N, Muguruma K, Yashiro M, Sawada T, Yamashita Y, Nishiguchi Y, Hirakawa K

    Gan to kagaku ryoho. Cancer & chemotherapy   36 ( 12 )   2436 - 8   2009.11( ISSN:0385-0684

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  • Epigenetic regulation of the embryonic oncogene ERas in gastric cancer cells Reviewed

    Yashiro Masakazu, Yasuda Koichi, Nishii Takafumi, Kaizaki Ryoji, Sawada Tetsuji, Ohira Masaichi, Hirakawa Kosei

    INTERNATIONAL JOURNAL OF ONCOLOGY   35 ( 5 )   997 - 1003   2009.11( ISSN:1019-6439

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    DOI: 10.3892/ijo_00000414

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  • Vitamin D receptor expression is associated with colon cancer in ulcerative colitis Reviewed

    Wada Koji, Tanaka Hiroaki, Maeda Kiyoshi, Inoue Toru, Noda Eiji, Amano Ryosuke, Kubo Naoshi, Muguruma Kazuya, Yamada Nobuya, Yashiro Masakazu, Sawada Tetsuji, Nakata Bunzo, Ohira Masaichi, Hirakawa Kosei

    ONCOLOGY REPORTS   22 ( 5 )   1021 - 1025   2009.11( ISSN:1021-335X

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    DOI: 10.3892/or_00000530

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  • Epigenetic regulation of the embryonic oncogene ERas in gastric cancer cells Reviewed

    Masakazu Yashiro, Koichi Yasuda, Takafumi Nishii, Ryoji Kaizaki, Tetsuji Sawada, Masaichi Ohira, Kosei Hirakawa

    INTERNATIONAL JOURNAL OF ONCOLOGY   35 ( 5 )   997 - 1003   2009.11( ISSN:1019-6439

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    ERas is a recently identified oncogene that supports the tumorigenic growth of embryonic stem cells, it is constitutively active in the absence of mutation. ERas oncogene is expressed only in viviparity phase cells, but not in somatic cells because of epigenetic transcriptional silencing in the somatic phase. The aim of this study was to clarify the ERas expression and its epigenetic regulation in gastric cancer of somatic phase. Fifteen gastric cancer cell lines were used. ERas mRNA expression and its epigenetic regulation were examined by reverse transcription-polymerase chain reaction and bisulfite sequencing analysis. To identify a subset of cancer stem cells, termed &apos;side population&apos; (SP) cells, flow cytometry analysis was performed. ERas is expressed in 8 of the 15 gastric cancer cell lines, but is silenced in the remaining 7 cancer cell lines and normal cell lines. Six of 7 cancer cell lines without ERas expression had promoter methylation, which correlated with silencing of ERas expression. ERas expression is re-activated following treatment with the DNA methyltransferase inhibitor 5-aza-CdR. The percentage of SP fraction of ERas-positive gastric cancer cells was significantly (p=0.024) higher (3.4+/-1.8%), in comparison to that of ERas-negative cells (1.6+/-0.4%). These findings suggested that the activating ERas oncogene might be associated with tumorigenic growth of somatic cells, and might be a putative molecule responsible for cancer stem cell-like characteristics in gastric cancer. Loss of methylation in the promoter of ERas might be one of mechanisms responsible for the re-expression of an embryonic oncogene in gastric cancer.

    DOI: 10.3892/ijo_00000414

    PubMed

  • [Concurrent chemoradiotherapy with nedaplatin and 5-fluorouracil (5-fu) for locally advanced squamous cell carcinoma of the esophagus]. Reviewed

    Kubo N, Morimoto J, Tanaka H, Ohira M, Noda E, Amano R, Inoue T, Yamada N, Yashiro M, Maeda K, Yamashita Y, Muguruma K, Sawada T, Hirakawa K

    Gan to kagaku ryoho. Cancer & chemotherapy   36 ( 12 )   1997 - 9   2009.11( ISSN:0385-0684

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    PubMed

  • [A case of stage IV advanced esophageal cancer with a long term survival by radiation therapy combined with nedaplatin and 5-FU chemotherapy]. Reviewed

    Morimoto J, Oohira M, Kubo N, Tanaka H, Dan N, Muguruma K, Yashiro M, Sawada T, Yamashita Y, Nishiguchi Y, Hirakawa K

    Gan to kagaku ryoho. Cancer & chemotherapy   36 ( 12 )   2436 - 8   2009.11( ISSN:0385-0684

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    PubMed

  • [A case of advanced esophageal cancer with para-aortic lymph node metastasis with complete response (CR) to combination chemotherapy including nedaplatin]. Reviewed

    Noda S, Kubo N, Tanaka H, Muguruma K, Yashiro M, Yamada N, Maeda K, Sawada T, Ohira M, Ishikawa T, Hirakawa K

    Gan to kagaku ryoho. Cancer & chemotherapy   36 ( 12 )   2451 - 3   2009.11( ISSN:0385-0684

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    PubMed

  • [Results of neo-adjuvant chemotherapy by FOLFOX and FOLFIRI for colorectal liver metastasis]. Reviewed

    Amano R, Yamada N, Noda E, Kubo N, Tanaka H, Muguruma K, Inoue T, Yashiro M, Maeda K, Onoda N, Sawada T, Nakata B, Ohira M, Ishikawa T, Hirakawa K

    Gan to kagaku ryoho. Cancer & chemotherapy   36 ( 12 )   2003 - 5   2009.11( ISSN:0385-0684

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  • Vitamin D receptor expression is associated with colon cancer in ulcerative colitis Reviewed

    Koji Wada, Hiroaki Tanaka, Kiyoshi Maeda, Toru Inoue, Eiji Noda, Ryosuke Amano, Naoshi Kubo, Kazuya Muguruma, Nobuya Yamada, Masakazu Yashiro, Tetsuji Sawada, Bunzo Nakata, Masaichi Ohira, Kosei Hirakawa

    ONCOLOGY REPORTS   22 ( 5 )   1021 - 5   2009.11( ISSN:1021-335X

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    Since the 1970s, it has been well known that long-standing ulcerative colitis (UC) disposes to the development of colorectal adenocarcinoma (CRC). To date, CRC associated with UC is thought to arise along a pathway of dysplasia, however, primary factors for developing of UC-related dysplasia and cancer are unclear. Vitamin D, which works through binding the vitamin D receptor (VDR) has an important role in cancer progression and immune response. In this study, we investigated the impact of VDR expression on UC as well as colon cancer. We examined retrospectively the expression of VDR in extraction specimens of UC (n=124) patients by immunohistochemistry. We counted VDR positive cells in at least 10 fields in each case to evaluate the frequency of VDR positive cells in ductal epithelium. In addition, effect of VDR expression on inflammation was analyzed. On a normal mucosa, the expression of VDR was recognized in 58.8% of ductal cells. In UC patient, the expression of VDR was considerably decreased compared to normal mucosa, VDR positive rate was only 3.4 +/- 9.0%. Importantly, dysplasia and UC-CRC patients showed lower rate of VDR expression compared to non-colon cancer patients, whose expression rates were 0.6 +/- 1.3% and 3.8 +/- 10%, respectively. Moreover, long-term UC patients (more than ten years) who were at high-risk of developing CRC showed significantly lower VDR expression than short-term patients. We did not detect direct association of VDR expression with inflammation and clinical stage of UC. These findings suggested that correlation seems to exist between the level of VDR expression and carcinogenesis in UC. VDR could be a possible marker to detect dysplasia and cancer in ulcerative colitis.

    DOI: 10.3892/or_00000530

    PubMed

  • 特集 できる!縫合・吻合 III.部位(術式)別の縫合・吻合法 3.胃 十二指腸切開部の手縫いによる縫合閉鎖 Reviewed

    豊川 貴弘, 澤田 鉄二, 久保 尚士, 田中 浩明, 六車 一哉, 八代 正和, 大平 雅一, 平川 弘聖

    臨床外科   64 ( 11 )   172 - 173   2009.10( ISSN:03869857 ( eISSN:18821278

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    DOI: 10.11477/mf.1407102789

  • Direct cancer-stromal interaction increases fibroblast proliferation and enhances invasive properties of scirrhous-type gastric carcinoma cells Reviewed

    Semba S., Kodama Y., Ohnuma K., Mizuuchi E., Masuda R., Yashiro M., Hirakawa K., Yokozaki H.

    BRITISH JOURNAL OF CANCER   101 ( 8 )   1365 - 1373   2009.10( ISSN:0007-0920

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    DOI: 10.1038/sj.bjc.6605309

  • c-Ski overexpression promotes tumor growth and angiogenesis through inhibition of transforming growth factor-β signaling in diffuse-type gastric carcinoma Reviewed

    KIYONO Kunihiko, SUZUKI Hiroshi I., MORISHITA Yasuyuki, KOMURO Akiyoshi, IWATA Caname, YASHIRO Masakazu, HIRAKAWA Kosei, KANO Mitsunobu R., MIYAZONO Kohei

    Cancer science   100 ( 10 )   1809 - 1816   2009.10( ISSN:13479032

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    CiNii Article

  • c-Ski overexpression promotes tumor growth and angiogenesis through inhibition of transforming growth factor-β signaling in diffuse-type gastric carcinoma Reviewed

    KIYONO Kunihiko, SUZUKI Hiroshi I., MORISHITA Yasuyuki, KOMURO Akiyoshi, IWATA Caname, YASHIRO Masakazu, HIRAKAWA Kosei, KANO Mitsunobu R., MIYAZONO Kohei

    Cancer Sci.   100 ( 10 )   1809 - 1816   2009.10( ISSN:13479032

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  • Effects of VEGFR-3 phosphorylation inhibitor on lymph node metastasis in an orthotopic diffuse-type gastric carcinoma model. Reviewed

    Yashiro M, Shinto O, Nakamura K, Tendo M, Matsuoka T, Matsuzaki T, Kaizaki R, Ohira M, Miwa A, Hirakawa K

    British journal of cancer   101 ( 7 )   1100 - 6   2009.10( ISSN:0007-0920

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    DOI: 10.1038/sj.bjc.6605296

    PubMed

  • Allelic Imbalance at p53 and Microsatellite Instability Are Predictive Markers for Resistance to Chemotherapy in Gastric Carcinoma Reviewed

    Yashiro Masakazu, Inoue Toru, Nishioka Nobuaki, Matsuoka Tasuku, Boland C. Richard, Hirakawa Kosei

    ANNALS OF SURGICAL ONCOLOGY   16 ( 10 )   2926 - 2935   2009.10( ISSN:1068-9265

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    DOI: 10.1245/s10434-009-0590-6

    PubMed

  • c-Ski overexpression promotes tumor growth and angiogenesis through inhibition of transforming growth factor-beta signaling in diffuse-type gastric carcinoma Reviewed

    Kiyono Kunihiko, Suzuki Hiroshi I., Morishita Yasuyuki, Komuro Akiyoshi, Iwata Caname, Yashiro Masakazu, Hirakawa Kosei, Kano Mitsunobu R., Miyazono Kohei

    CANCER SCIENCE   100 ( 10 )   1809 - 1816   2009.10( ISSN:1349-7006

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    DOI: 10.1111/j.1349-7006.2009.01248.x

    PubMed

  • Allelic Imbalance at p53 and Microsatellite Instability Are Predictive Markers for Resistance to Chemotherapy in Gastric Carcinoma Reviewed

    Masakazu Yashiro, Toru Inoue, Nobuaki Nishioka, Tasuku Matsuoka, C. Richard Boland, Kosei Hirakawa

    ANNALS OF SURGICAL ONCOLOGY   16 ( 10 )   2926 - 35   2009.10( ISSN:1068-9265

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    Combined treatment with 5-fluorouracil and cisplatin (FP chemotherapy) is an effective neoadjuvant regimen for gastric carcinoma. However, it is ineffective in half of all patients. This study tests the hypothesis that genetic markers might identify those patients with gastric cancer who would respond to neoadjuvant FP chemotherapy.
    A total of 23 patients with gastric carcinoma were treated with neoadjuvant chemotherapy. Pretreatment biopsy specimens before neoadjuvant chemotherapy were obtained from 15 of 23 patients, and resected tumors were obtained from all 23. Genetic studies were performed to detect allelic imbalance (AI), microsatellite instability (MSI), and K-ras mutation.
    A clinical response was observed in 13 of 23 patients. Kaplan-Meier survival curve showed that clinical responder group had a significantly higher likelihood of overall survival (P = 0.0165), compared with nonresponder group. In 23 resection specimens, 10 of 23 tumors presented AI at the p53 locus and/or MSI; 8 of the 10 tumors were nonresponders, while 12 of 13 tumors without p53 AI or MSI were responders (P = 0.0007). In 15 pretreatment biopsy specimens, 8 tumors had p53 AI and/or MSI; 7 of the 8 tumors were nonresponders, while 6 of 7 tumors without p53 AI or MSI were responders to preoperative chemotherapy (P = 0.008). Tumors with AI at the p53 locus and/or MSI were significantly more resistant to neoadjuvant chemotherapy. No relationship was found between K-ras mutations and responses.
    Analysis for p53 AI and MSI might represent a clinically useful approach to predicting the response to neoadjuvant FP chemotherapy in gastric carcinoma.

    DOI: 10.1245/s10434-009-0590-6

    PubMed

  • c-Ski overexpression promotes tumor growth and angiogenesis through inhibition of transforming growth factor-beta signaling in diffuse-type gastric carcinoma Reviewed

    Kunihiko Kiyono, Hiroshi I. Suzuki, Yasuyuki Morishita, Akiyoshi Komuro, Caname Iwata, Masakazu Yashiro, Kosei Hirakawa, Mitsunobu R. Kano, Kohei Miyazono

    CANCER SCIENCE   100 ( 10 )   1809 - 1816   2009.10( ISSN:1347-9032 ( eISSN:1349-7006

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    c-Ski, originally identified as a proto-oncogene product, is an important negative regulator of transforming growth factor (TGF)-beta family signaling through interaction with Smad2, Smad3, and Smad4. High expression of c-Ski has been found in some cancers, including gastric cancer. We previously showed that disruption of TGF-beta signaling by dominant-negative TGF-beta type II receptor in a diffuse-type gastric carcinoma model accelerated tumor growth through induction of tumor angiogenesis by decreased expression of the anti-angiogenic factor thrombospondin (TSP)-1. Here, we examined the function of c-Ski in human diffuse-type gastric carcinoma OCUM-2MLN cells. Overexpression of c-Ski inhibited TGF-beta signaling in OCUM-2MLN cells. Interestingly, c-Ski overexpression resulted in extensive acceleration of the growth of subcutaneous xenografts in BALB/c nu/nu female mice (6 weeks of age). Similar to tumors expressing dominant-negative TGF-beta type II receptor, histochemical studies revealed less fibrosis and increased angiogenesis in xenografted tumors expressing c-Ski compared to control tumors. Induction of TSP-1 mRNA by TGF-beta was attenuated by c-Ski in vitro, and expression of TSP-1 mRNA was decreased in tumors expressing c-Ski in vivo. These findings suggest that c-Ski overexpression promotes the growth of diffuse-type gastric carcinoma through induction of angiogenesis. (Cancer Sci 2009; 100: 1809-1816).

    DOI: 10.1111/j.1349-7006.2009.01248.x

    PubMed

  • Direct cancer-stromal interaction increases fibroblast proliferation and enhances invasive properties of scirrhous-type gastric carcinoma cells Reviewed

    Semba S, Kodama Y, Ohnuma K, Mizuuchi E, Masuda R, Yashiro M, Hirakawa K, Yokozaki H

    Br J Cancer   101 ( 8 )   1365 - 1373   2009.10

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    DOI: 10.1038/sj.bjc.6605309

  • Effects of VEGFR-3 phosphorylation inhibitor on lymph node metastasis in an orthotopic diffuse-type gastric carcinoma model Reviewed

    Yashiro M., Shinto O., Nakamura K., Tendo M., Matsuoka T., Matsuzaki T., Kaizaki R., Ohira M., Miwa A., Hirakawa K.

    BRITISH JOURNAL OF CANCER   101 ( 7 )   1100 - 1106   2009.09( ISSN:0007-0920

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    DOI: 10.1038/sj.bjc.6605296

  • Cancer stem cell-like SP cells have a high adhesion ability to the peritoneum in gastric carcinoma Reviewed

    Nishii Takafumi, Yashiro Masakazu, Shinto Osamu, Sawada Tetsuji, Ohira Masaichi, Hirakawa Kosei

    CANCER SCIENCE   100 ( 8 )   1397 - 1402   2009.08( ISSN:1349-7006

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    DOI: 10.1111/j.1349-7006.2009.01211.x

    PubMed

  • Cancer stem cell-like SP cells have a high adhesion ability to the peritoneum in gastric carcinoma Reviewed

    Takafumi Nishii, Masakazu Yashiro, Osamu Shinto, Tetsuji Sawada, Masaichi Ohira, Kosei Hirakawa

    CANCER SCIENCE   100 ( 8 )   1397 - 402   2009.08( ISSN:1347-9032

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    Cancer stem cells (CSCs) are considered to be responsible for cancer metastasis, but the evidence to conclusively prove this hypothesis remains uncertain. The side population (SP), as evaluated by a flow cytometric analysis using Hoechst 33342, has been known as CSC-rich population. The aim of this study was to clarify the characterization of the SP cells in peritoneal metastasis of gastric carcinoma. Gastric cancer cell lines OCUM-2M, OCUM-2D, and OCUM-2MD3 (a daughter cell line with high potential for peritoneal metastasis) were used. We isolated SP cells from OCUM-2M and OCUM-2D using flow cytometry. Serial sorting was performed three times to enrich SP cells, and they were designated as OCUM-2M/SP and OCUM-2D/SP cells. Flow cytometric analysis showed 0.46%, 0.29%, 5.24%, 6.49%, and 11.3% of the SP cells to be found in OCUM-2M, OCUM-2D, OCUM-2MD3, OCUM-2M/SP, and OCUM-2D/SP cells, respectively. The intraperitoneal inoculation of SP cells and OCUM-2MD3 cells produced peritoneal metastasis, but parent cells did not. The adhesion ability of SP and OCUM-2MD3 cells was significantly high in comparison to that of parent cells. The expression level of adhesion molecules alpha 2-, alpha 5-, beta 3-, and beta 5-integrin, and CD44, was high in SP cells compared to parent cells. The expression of stemness markers, Oct3/4 and Sox2, increased in the SP-cell-injected tumors. These findings suggested that CSC-like SP cells expressing alpha 2-, alpha 5-, beta 3-, and beta 5-integrin, and CD44, may play an important role for peritoneal metastasis in gastric carcinoma. Oct3/4 and Sox2 may be associated with CSC in gastric cancer. (Cancer Sci 2009).

    DOI: 10.1111/j.1349-7006.2009.01211.x

    PubMed

  • HER2 overexpression correlates with survival after curative resection of pancreatic cancer Reviewed

    KOMOTO Masahiro, NAKATA Bunzo, AMANO Ryosuke, YAMADA Nobuya, YASHIRO Masakazu, OHIRA Masaichi, WAKASA Kenichi, HIRAKAWA Kosei

    Cancer science   100 ( 7 )   1243 - 1247   2009.07( ISSN:13479032

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  • HER2 overexpression correlates with survival after curative resection of pancreatic cancer Reviewed

    KOMOTO Masahiro, NAKATA Bunzo, AMANO Ryosuke, YAMADA Nobuya, YASHIRO Masakazu, OHIRA Masaichi, WAKASA Kenichi, HIRAKAWA Kosei

    Cancer Sci   100 ( 7 )   1243 - 1247   2009.07( ISSN:13479032

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  • O-1-4 切除再建例の臨床病理所見,異時性頭頚部癌の治療法からみたcStageI胸部食道癌の治療戦略(企画関連口演1 StageI食道癌1,第64回日本消化器外科学会総会) Reviewed

    大平 雅一, 久保 尚士, 田中 浩明, 六車 一哉, 山田 靖哉, 八代 正和, 前田 清, 澤田 鉄二, 山下 好人, 平川 弘聖

    一般社団法人日本消化器外科学会 日本消化器外科学会雑誌   42 ( 7 )   2009.07( ISSN:03869768

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  • RS-23-7 当教室における潰瘍性大腸炎に対する腹腔鏡下手術の現状(要望演題23-2 炎症性腸疾患に対する外科治療2,第64回日本消化器外科学会総会) Reviewed

    前田 清, 井上 透, 野田 英児, 埜村 真也, 八代 正和, 山田 靖哉, 澤田 鉄二, 西口 幸雄, 池原 照幸, 平川 弘聖

    一般社団法人日本消化器外科学会 日本消化器外科学会雑誌   42 ( 7 )   2009.07( ISSN:03869768

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  • RS-20-3 大腸癌イレウスに対する腸管減圧法と治療成績(要望演題20-1 大腸癌イレウスの治療方針1,第64回日本消化器外科学会総会) Reviewed

    井上 透, 前田 清, 野田 英児, 埜村 真也, 八代 正和, 山田 靖哉, 澤田 鉄二, 西口 幸雄, 大平 雅一, 平川 弘聖

    一般社団法人日本消化器外科学会 日本消化器外科学会雑誌   42 ( 7 )   2009.07( ISSN:03869768

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  • PD-3-7 切除可能進行胃癌に対するNeoadjuvant Chemotherapy(NAC)の有用性について(パネルディスカッション3 切除可能胃癌に対するNeoadjuvant療法,第64回日本消化器外科学会総会) Reviewed

    六車 一哉, 澤田 鉄二, 豊川 貴弘, 久保 尚士, 田中 浩明, 八代 正和, 山田 靖哉, 山下 好人, 大平 雅一, 平川 弘聖

    一般社団法人日本消化器外科学会 日本消化器外科学会雑誌   42 ( 7 )   2009.07( ISSN:03869768

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  • P-3-59 センチネルノードナビゲーションを応用した早期胃癌縮小手術(胃・十二指腸 早期癌1,一般演題(ポスター),第64回日本消化器外科学会総会) Reviewed

    吉井 真美, 澤田 鉄二, 六車 一哉, 久保 尚士, 田中 浩明, 豊川 貴弘, 八代 正和, 大平 雅一, 石川 哲郎, 平川 弘聖

    一般社団法人日本消化器外科学会 日本消化器外科学会雑誌   42 ( 7 )   2009.07( ISSN:03869768

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  • P-3-32 進行食道癌に対する5-FU/nedaplatin(CDGP)放射線併用療法による集学的治療(食道 CRT,一般演題(ポスター),第64回日本消化器外科学会総会) Reviewed

    久保 尚士, 田中 浩明, 大平 雅一, 山下 好人, 六車 一哉, 澤田 鉄二, 西口 幸雄, 八代 正和, 山田 靖哉, 平川 弘聖

    一般社団法人日本消化器外科学会 日本消化器外科学会雑誌   42 ( 7 )   2009.07( ISSN:03869768

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  • P-2-87 低酸素が胃癌細胞の腹膜接着能におよぼす影響(胃・十二指腸 基礎2,一般演題(ポスター),第64回日本消化器外科学会総会) Reviewed

    野田 諭, 八代 正和, 田中 浩明, 井上 透, 山田 靖哉, 前田 清, 澤田 鉄二, 大平 雅一, 石川 哲郎, 平川 弘聖

    一般社団法人日本消化器外科学会 日本消化器外科学会雑誌   42 ( 7 )   2009.07( ISSN:03869768

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  • P-2-515 膵癌細胞に及ぼすMUC5ACの影響およびHLA拘束性エピトープペプチドワクチンの可能性(膵基礎1,一般演題(ポスター),第64回日本消化器外科学会総会) Reviewed

    山添 定明, 田中 浩明, 岩内 武彦, 山田 靖哉, 八代 正和, 前田 清, 澤田 鉄二, 仲田 文造, 大平 雅一, 平川 弘聖

    一般社団法人日本消化器外科学会 日本消化器外科学会雑誌   42 ( 7 )   2009.07( ISSN:03869768

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  • P-1-59 胃癌微小環境における筋線維芽細胞およびvimentin陽性胃癌細胞の意義(胃・十二指腸 研究3,一般演題(ポスター),第64回日本消化器外科学会総会) Reviewed

    冬廣 雄彦, 八代 正和, 加藤 幸裕, 柏木 伸一郎, 野田 諭, 井上 透, 澤田 鉄二, 大平 雅一, 石川 哲郎, 平川 弘聖

    一般社団法人日本消化器外科学会 日本消化器外科学会雑誌   42 ( 7 )   2009.07( ISSN:03869768

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  • P-1-55 胃癌組織における低酸素状態の臨床病理学的意義(胃・十二指腸 研究3,一般演題(ポスター),第64回日本消化器外科学会総会) Reviewed

    加藤 幸裕, 八代 正和, 野田 諭, 西居 孝文, 土井 洋輔, 神藤 理, 前田 清, 澤田 鉄二, 大平 雅一, 平川 弘聖

    一般社団法人日本消化器外科学会 日本消化器外科学会雑誌   42 ( 7 )   2009.07( ISSN:03869768

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  • P-1-468 膵癌に対するS-1+lapatinib併用療法の基礎的検討(膵 集学的治療,一般演題(ポスター),第64回日本消化器外科学会総会) Reviewed

    河本 真大, 仲田 文造, 天野 良亮, 山田 靖哉, 八代 正和, 平川 弘聖

    一般社団法人日本消化器外科学会 日本消化器外科学会雑誌   42 ( 7 )   2009.07( ISSN:03869768

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  • O-3-18 切除不能stageIV進行胃癌に対する化学療法後切除症例の検討(企画関連口演41 新規抗癌剤と胃癌手術1,第64回日本消化器外科学会総会) Reviewed

    澤田 鉄二, 六車 一哉, 田中 浩明, 久保 尚士, 豊川 貴弘, 貝崎 亮二, 神藤 理, 八代 正和, 大平 雅一, 平川 弘聖

    一般社団法人日本消化器外科学会 日本消化器外科学会雑誌   42 ( 7 )   2009.07( ISSN:03869768

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  • O-2-61 予後から見た食道胃接合部癌のリンパ節転移の特徴とその治療戦略(企画関連口演30 Barrett食道癌2,第64回日本消化器外科学会総会) Reviewed

    田中 浩明, 大平 雅一, 久保 尚士, 六車 一哉, 澤田 鉄二, 豊川 貴弘, 山下 好人, 八代 正和, 山田 靖哉, 平川 弘聖

    一般社団法人日本消化器外科学会 日本消化器外科学会雑誌   42 ( 7 )   2009.07( ISSN:03869768

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  • O-2-17 Toll like receptor4 ligandとTGFβ阻害剤の併用による消化器癌宿主の免疫寛容克服(企画関連口演21 免疫化学療法1,第64回日本消化器外科学会総会) Reviewed

    岩内 武彦, 田中 浩明, 山添 定明, 久保 尚士, 六車 一哉, 八代 正和, 山田 靖哉, 澤田 鉄二, 大平 雅一, 平川 弘聖

    一般社団法人日本消化器外科学会 日本消化器外科学会雑誌   42 ( 7 )   2009.07( ISSN:03869768

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  • O-1-69 大腸癌同時性肝転移の治療戦略(企画関連口演14 同時性両葉肝転移2,第64回日本消化器外科学会総会) Reviewed

    天野 良亮, 山田 靖哉, 野田 英児, 八代 正和, 前田 清, 澤田 鉄二, 仲田 文造, 大平 雅一, 石川 哲郎, 平川 弘聖

    一般社団法人日本消化器外科学会 日本消化器外科学会雑誌   42 ( 7 )   2009.07( ISSN:03869768

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  • WS-5-5 残胃の癌の臨床病理およびサーベイランスの検討(ワークショップ5 残胃癌に対する治療戦略,第64回日本消化器外科学会総会) Reviewed

    豊川 貴弘, 六車 一哉, 澤田 鉄二, 久保 尚士, 田中 浩明, 八代 正和, 山下 好人, 大平 雅一, 石川 哲郎, 平川 弘聖

    一般社団法人日本消化器外科学会 日本消化器外科学会雑誌   42 ( 7 )   2009.07( ISSN:03869768

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  • RS-24-7 当科で経験したGIST切除症例の検討(要望演題24-2 消化管GISTに対する診断と治療2,第64回日本消化器外科学会総会) Reviewed

    貝崎 亮二, 六車 一哉, 豊川 貴弘, 久保 尚士, 田中 浩明, 八代 正和, 澤田 鉄二, 大平 雅一, 石川 哲郎, 平川 弘聖

    一般社団法人日本消化器外科学会 日本消化器外科学会雑誌   42 ( 7 )   2009.07( ISSN:03869768

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  • Laparoscopic Surgery for Ulcerative Colitis : selection of Surgical Procedure According to the Degree of Emergency Reviewed

    MAEDA Kiyoshi, NODA Eiji, INOUE Toru, OSHITANI Nobuhide, WATANABE Kennji, YAMAGAMI Hirokazu, KAMATA Noriko, SOGAWA Mitue, YASHIRO Masakazu, YAMADA Nobuya, NISHIGUCHI Yukio, IKEHARA Teruyuki, HIRAKAWA Kosei

    The Japan Society of Coloproctology, Nippon Daicho Komonbyo Gakkai Zasshi   62 ( 7 )   453 - 460   2009.07( ISSN:00471801

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    We have performed laparo-assisted (LA-RPC) or hand-assisted laparoscopic (HALS) restorative proctocolectomy for elective patients with ulcerative colitis. For patients who need semi-emergency operation, we have performed HALS total colectomy. In this report, we investigate the propriety of these laparoscopic surgical procedures.<br> We compare the clinical outcomes between the 74 patients who underwent laparoscopic surgery form July 2001 to September 2008 and the 56 patients who underwent the conventional surgical procedure from 1997 to 2001.<br> As for the elective patients, although the operation time was longer in LA-RPC, the blood loss was significantly less and the length of hospital stay was significantly shorter in LA-RPC, compared with conventional laparotomy. Moreover, in the patients who underwent semi-emergency surgery, in the HALS group although the operation time was slightly longer the blood loss was significantly less and the length of hospital stay was significantly shorter.<br> In conclusion, further examination is necessary, but it is thought that especially for LA-RPC, although the operation time is longer, recovery after operation is quicker, and body appearance is better. HALS is considered to be a standard technique for semi-emergency operation, because the operation time is only slighly longer and recovery is quicker.<br>

    DOI: 10.3862/jcoloproctology.62.453

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  • O-1-4 切除再建例の臨床病理所見,異時性頭頚部癌の治療法からみたcStageI胸部食道癌の治療戦略(企画関連口演1 StageI食道癌1,第64回日本消化器外科学会総会) Reviewed

    大平 雅一, 久保 尚士, 田中 浩明, 六車 一哉, 山田 靖哉, 八代 正和, 前田 清, 澤田 鉄二, 山下 好人, 平川 弘聖

    日本消化器外科学会雑誌   42 ( 7 )   1069   2009.07( ISSN:03869768

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  • O-1-69 大腸癌同時性肝転移の治療戦略(企画関連口演14 同時性両葉肝転移2,第64回日本消化器外科学会総会) Reviewed

    天野 良亮, 山田 靖哉, 野田 英児, 八代 正和, 前田 清, 澤田 鉄二, 仲田 文造, 大平 雅一, 石川 哲郎, 平川 弘聖

    日本消化器外科学会雑誌   42 ( 7 )   1077   2009.07( ISSN:03869768

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  • O-2-17 Toll like receptor4 ligandとTGFβ阻害剤の併用による消化器癌宿主の免疫寛容克服(企画関連口演21 免疫化学療法1,第64回日本消化器外科学会総会) Reviewed

    岩内 武彦, 田中 浩明, 山添 定明, 久保 尚士, 六車 一哉, 八代 正和, 山田 靖哉, 澤田 鉄二, 大平 雅一, 平川 弘聖

    日本消化器外科学会雑誌   42 ( 7 )   1085   2009.07( ISSN:03869768

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  • WS-5-5 残胃の癌の臨床病理およびサーベイランスの検討(ワークショップ5 残胃癌に対する治療戦略,第64回日本消化器外科学会総会) Reviewed

    豊川 貴弘, 六車 一哉, 澤田 鉄二, 久保 尚士, 田中 浩明, 八代 正和, 山下 好人, 大平 雅一, 石川 哲郎, 平川 弘聖

    日本消化器外科学会雑誌   42 ( 7 )   988   2009.07( ISSN:03869768

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  • RS-24-7 当科で経験したGIST切除症例の検討(要望演題24-2 消化管GISTに対する診断と治療2,第64回日本消化器外科学会総会) Reviewed

    貝崎 亮二, 六車 一哉, 豊川 貴弘, 久保 尚士, 田中 浩明, 八代 正和, 澤田 鉄二, 大平 雅一, 石川 哲郎, 平川 弘聖

    日本消化器外科学会雑誌   42 ( 7 )   1062   2009.07( ISSN:03869768

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  • RS-23-7 当教室における潰瘍性大腸炎に対する腹腔鏡下手術の現状(要望演題23-2 炎症性腸疾患に対する外科治療2,第64回日本消化器外科学会総会) Reviewed

    前田 清, 井上 透, 野田 英児, 埜村 真也, 八代 正和, 山田 靖哉, 澤田 鉄二, 西口 幸雄, 池原 照幸, 平川 弘聖

    日本消化器外科学会雑誌   42 ( 7 )   1060   2009.07( ISSN:03869768

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  • RS-20-3 大腸癌イレウスに対する腸管減圧法と治療成績(要望演題20-1 大腸癌イレウスの治療方針1,第64回日本消化器外科学会総会) Reviewed

    井上 透, 前田 清, 野田 英児, 埜村 真也, 八代 正和, 山田 靖哉, 澤田 鉄二, 西口 幸雄, 大平 雅一, 平川 弘聖

    日本消化器外科学会雑誌   42 ( 7 )   1055   2009.07( ISSN:03869768

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  • PD-3-7 切除可能進行胃癌に対するNeoadjuvant Chemotherapy(NAC)の有用性について(パネルディスカッション3 切除可能胃癌に対するNeoadjuvant療法,第64回日本消化器外科学会総会) Reviewed

    六車 一哉, 澤田 鉄二, 豊川 貴弘, 久保 尚士, 田中 浩明, 八代 正和, 山田 靖哉, 山下 好人, 大平 雅一, 平川 弘聖

    日本消化器外科学会雑誌   42 ( 7 )   959   2009.07( ISSN:03869768

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  • P-3-59 センチネルノードナビゲーションを応用した早期胃癌縮小手術(胃・十二指腸 早期癌1,一般演題(ポスター),第64回日本消化器外科学会総会) Reviewed

    吉井 真美, 澤田 鉄二, 六車 一哉, 久保 尚士, 田中 浩明, 豊川 貴弘, 八代 正和, 大平 雅一, 石川 哲郎, 平川 弘聖

    日本消化器外科学会雑誌   42 ( 7 )   1302   2009.07( ISSN:03869768

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  • P-3-32 進行食道癌に対する5-FU/nedaplatin(CDGP)放射線併用療法による集学的治療(食道 CRT,一般演題(ポスター),第64回日本消化器外科学会総会) Reviewed

    久保 尚士, 田中 浩明, 大平 雅一, 山下 好人, 六車 一哉, 澤田 鉄二, 西口 幸雄, 八代 正和, 山田 靖哉, 平川 弘聖

    日本消化器外科学会雑誌   42 ( 7 )   1298   2009.07( ISSN:03869768

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  • P-2-87 低酸素が胃癌細胞の腹膜接着能におよぼす影響(胃・十二指腸 基礎2,一般演題(ポスター),第64回日本消化器外科学会総会) Reviewed

    野田 諭, 八代 正和, 田中 浩明, 井上 透, 山田 靖哉, 前田 清, 澤田 鉄二, 大平 雅一, 石川 哲郎, 平川 弘聖

    日本消化器外科学会雑誌   42 ( 7 )   1213   2009.07( ISSN:03869768

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  • P-2-515 膵癌細胞に及ぼすMUC5ACの影響およびHLA拘束性エピトープペプチドワクチンの可能性(膵基礎1,一般演題(ポスター),第64回日本消化器外科学会総会) Reviewed

    山添 定明, 田中 浩明, 岩内 武彦, 山田 靖哉, 八代 正和, 前田 清, 澤田 鉄二, 仲田 文造, 大平 雅一, 平川 弘聖

    日本消化器外科学会雑誌   42 ( 7 )   1267   2009.07( ISSN:03869768

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  • P-1-59 胃癌微小環境における筋線維芽細胞およびvimentin陽性胃癌細胞の意義(胃・十二指腸 研究3,一般演題(ポスター),第64回日本消化器外科学会総会) Reviewed

    冬廣 雄彦, 八代 正和, 加藤 幸裕, 柏木 伸一郎, 野田 諭, 井上 透, 澤田 鉄二, 大平 雅一, 石川 哲郎, 平川 弘聖

    日本消化器外科学会雑誌   42 ( 7 )   1130   2009.07( ISSN:03869768

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  • P-1-55 胃癌組織における低酸素状態の臨床病理学的意義(胃・十二指腸 研究3,一般演題(ポスター),第64回日本消化器外科学会総会) Reviewed

    加藤 幸裕, 八代 正和, 野田 諭, 西居 孝文, 土井 洋輔, 神藤 理, 前田 清, 澤田 鉄二, 大平 雅一, 平川 弘聖

    日本消化器外科学会雑誌   42 ( 7 )   1129   2009.07( ISSN:03869768

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  • P-1-468 膵癌に対するS-1+lapatinib併用療法の基礎的検討(膵 集学的治療,一般演題(ポスター),第64回日本消化器外科学会総会) Reviewed

    河本 真大, 仲田 文造, 天野 良亮, 山田 靖哉, 八代 正和, 平川 弘聖

    日本消化器外科学会雑誌   42 ( 7 )   1181   2009.07( ISSN:03869768

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  • O-3-18 切除不能stageIV進行胃癌に対する化学療法後切除症例の検討(企画関連口演41 新規抗癌剤と胃癌手術1,第64回日本消化器外科学会総会) Reviewed

    澤田 鉄二, 六車 一哉, 田中 浩明, 久保 尚士, 豊川 貴弘, 貝崎 亮二, 神藤 理, 八代 正和, 大平 雅一, 平川 弘聖

    日本消化器外科学会雑誌   42 ( 7 )   1101   2009.07( ISSN:03869768

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  • O-2-61 予後から見た食道胃接合部癌のリンパ節転移の特徴とその治療戦略(企画関連口演30 Barrett食道癌2,第64回日本消化器外科学会総会) Reviewed

    田中 浩明, 大平 雅一, 久保 尚士, 六車 一哉, 澤田 鉄二, 豊川 貴弘, 山下 好人, 八代 正和, 山田 靖哉, 平川 弘聖

    日本消化器外科学会雑誌   42 ( 7 )   1090   2009.07( ISSN:03869768

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  • HER2 overexpression correlates with survival after curative resection of pancreatic cancer Reviewed

    Komoto Masahiro, Nakata Bunzo, Amano Ryosuke, Yamada Nobuya, Yashiro Masakazu, Ohira Masaichi, Wakasa Kenichi, Hirakawa Kosei

    CANCER SCIENCE   100 ( 7 )   1243 - 1247   2009.07( ISSN:1349-7006

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    DOI: 10.1111/j.1349-7006.2009.01176.x

    PubMed

  • HER2 overexpression correlates with survival after curative resection of pancreatic cancer Reviewed

    Masahiro Komoto, Bunzo Nakata, Ryosuke Amano, Nobuya Yamada, Masakazu Yashiro, Masaichi Ohira, Kenichi Wakasa, Kosei Hirakawa

    CANCER SCIENCE   100 ( 7 )   1243 - 7   2009.07( ISSN:1347-9032

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    HER2 overexpression has been linked to clinical outcomes in several solid tumors, such as breast cancer. However, the correlation between HER2 overexpression and survival in pancreatic carcinoma remains unclear. The impact of HER2 overexpression on survival in pancreatic ductal cancer was examined. Immunohistochemical staining of 129 pancreatic cancers without hematogenous metastases or peritoneal dissemination treated by macroscopically curative resection were analyzed in association with survival data. To determine HER2 overexpression in this pancreatic cancer series, the polyclonal antibody included in HercepTest, which is used worldwide for clinical examination of HER2 overexpression in breast cancer, was used. Immunoreactivity was classified according to the scale presented in the HercepTest Scoring Guidelines. Twenty-two cases (17.1%) had a score of 0, 28 cases (21.7%) had of a score of 1+, 41 cases (31.8%) had a score of 2+, and 38 cases (29.4%) had a score of 3+. Therefore, HER2 overexpression (score 2+ or 3+) was observed in 79 cases (61.2%). Patients with HER2 overexpression tumors had significantly shorter survival times than those with HER2 normal expression (score 0 or 1+) tumors (median survival time, 14.7 vs 20.7 months, respectively; P = 0.0078 on the log-rank test). On multivariate survival analysis, HER2 overexpression remained an independent prognostic factor (hazard ratio, 1.806; P = 0.0258). A significant percentage of pancreatic cancers were demonstrated to have HER2 overexpression, and overexpression of this tyrosine kinase receptor proved to be an independent factor for a worse prognosis. These results should encourage further investigation of treatments using new molecular targeting agents against HER2 protein to improve the survival of pancreatic cancer patients. (Cancer Sci 2009; 100: 1243-1247)

    DOI: 10.1111/j.1349-7006.2009.01176.x

    PubMed

  • O15-1 高齢者胃癌切除症例の検討(第38回胃外科・術後障害研究会) Reviewed

    豊川 貴弘, 六車 一哉, 久保 尚士, 田中 浩明, 八代 正和, 澤田 鉄二, 大平 雅一, 石川 哲郎, 平川 弘聖

    一般社団法人日本消化器外科学会 日本消化器外科学会雑誌   42 ( 6 )   2009.06( ISSN:03869768

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  • O18-3 根治切除不能進行胃癌に対する外科治療(第38回胃外科・術後障害研究会) Reviewed

    中本 健太郎, 六車 一哉, 豊川 貴弘, 久保 尚士, 田中 浩明, 八代 正和, 澤田 鉄二, 大平 雅一, 石川 哲郎, 平川 弘聖

    一般社団法人日本消化器外科学会 日本消化器外科学会雑誌   42 ( 6 )   2009.06( ISSN:03869768

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  • O15-4 胃癌手術における肥満の影響(第38回胃外科・術後障害研究会) Reviewed

    檀 信浩, 六車 一哉, 豊川 貴弘, 久保 尚士, 田中 浩明, 八代 正和, 澤田 鉄二, 大平 雅一, 石川 哲郎, 平川 弘聖

    一般社団法人日本消化器外科学会 日本消化器外科学会雑誌   42 ( 6 )   2009.06( ISSN:03869768

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  • O15-1 高齢者胃癌切除症例の検討(第38回胃外科・術後障害研究会) Reviewed

    豊川 貴弘, 六車 一哉, 久保 尚士, 田中 浩明, 八代 正和, 澤田 鉄二, 大平 雅一, 石川 哲郎, 平川 弘聖

    日本消化器外科学会雑誌   42 ( 6 )   726   2009.06( ISSN:03869768

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  • O18-3 根治切除不能進行胃癌に対する外科治療(第38回胃外科・術後障害研究会) Reviewed

    中本 健太郎, 六車 一哉, 豊川 貴弘, 久保 尚士, 田中 浩明, 八代 正和, 澤田 鉄二, 大平 雅一, 石川 哲郎, 平川 弘聖

    日本消化器外科学会雑誌   42 ( 6 )   728   2009.06( ISSN:03869768

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  • O15-4 胃癌手術における肥満の影響(第38回胃外科・術後障害研究会) Reviewed

    檀 信浩, 六車 一哉, 豊川 貴弘, 久保 尚士, 田中 浩明, 八代 正和, 澤田 鉄二, 大平 雅一, 石川 哲郎, 平川 弘聖

    日本消化器外科学会雑誌   42 ( 6 )   726   2009.06( ISSN:03869768

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  • Local angiotensin II-generation in human gastric cancer: Correlation with tumor progression through the activation of ERK1/2, NF-kappa B and survivin Reviewed

    Kinoshita Jun, Fushida Sachio, Harada Shinichi, Yagi Yasumichi, Fujita Hideto, Kinami Shinichi, Ninomiya Itasu, Fujimura Takashi, Kayahara Masato, Yashiro Masakazu, Hirakawa Kosei, Ohta Tetsuo

    INTERNATIONAL JOURNAL OF ONCOLOGY   34 ( 6 )   1573 - 1582   2009.06( ISSN:1019-6439

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    DOI: 10.3892/ijo_00000287

    PubMed

  • Expression of ERas oncogene in gastric carcinoma. Reviewed

    Kaizaki R, Yashiro M, Shinto O, Yasuda K, Matsuzaki T, Sawada T, Hirakawa K

    Anticancer research   29 ( 6 )   2189 - 93   2009.06( ISSN:0250-7005

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    PubMed

  • Expression of ERas Oncogene in Gastric Carcinoma Reviewed

    Kaizaki Ryoji, Yashiro Masakazu, Shinto Osamu, Yasuda Koichi, Matsuzaki Taro, Sawada Tetsuji, Hirakawa Kosei

    ANTICANCER RESEARCH   29 ( 6 )   2189 - 2193   2009.06( ISSN:0250-7005

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  • Expression of ERas Oncogene in Gastric Carcinoma Reviewed

    Ryoji Kaizaki, Masakazu Yashiro, Osamu Shinto, Koichi Yasuda, Taro Matsuzaki, Tetsuji Sawada, Kosei Hirakawa

    ANTICANCER RESEARCH   29 ( 6 )   2189 - 2193   2009.06( ISSN:0250-7005

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    Background: Embryonic stem cell expressed Ras (ERas) oncogene is associated with the tumorigenicity of embryonic stem cells. The aim of this study was to clarify the significance of ERas expression in clinical samples of gastric carcinomas. Materials and Methods: Three hundred and few tissues from gastric cancer patients were analyzed by immunohistochemical techniques using an anti-ERas antibody. ERas mRNA expression in 77 gastric carcinomas was examined by reverse-transcription polymerase chain reaction. Results: ERas expression was positive in 135 (44%) of 304 gastric carcinomas. ERas-positive expression had a significant relationship with invasion depth (p&lt;0.01), histological type (p&lt;0.01), clinical stage (p=0.013) and curability (p=0.001). Prognosis of ERas-negative patients was significantly (p=0.029) poorer than that of ERas-positive patients, while ERas was not an independent prognostic factor. Expression of ERas mRNA was found in 35 (45%) out of 77 gastric cancer tissues. Conclusion: ERas oncogene is associated with the tumorigenic process of human gastric carcinomas.

    PubMed

  • Local angiotensin II-generation in human gastric cancer: Correlation with tumor progression through the activation of ERK1/2, NF-kappa B and survivin Reviewed

    Jun Kinoshita, Sachio Fushida, Shinichi Harada, Yasumichi Yagi, Hideto Fujita, Shinichi Kinami, Itasu Ninomiya, Takashi Fujimura, Masato Kayahara, Masakazu Yashiro, Kosei Hirakawa, Tetsuo Ohta

    INTERNATIONAL JOURNAL OF ONCOLOGY   34 ( 6 )   1573 - 1582   2009.06( ISSN:1019-6439

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    Angiotensin II is a main effector peptide in renin-angiotensin system, acting as a growth promoter via angiotensin II type 1 (AT1) receptor. The present study examined intrinsic angiotensin II generating system in gastric cancer and potential roles of angiotensin II in cellular proliferation and survival. The expression of AT1 receptor was examined in gastric cancer cell lines and tissues. In addition, we measured angiotensin II concentration in tissues from twenty gastric cancer and corresponding normal region using the florisil method. In vitro, we investigated the potential roles of angiotensin H in cellular proliferation and cell survival in cultured human gastric cancer cell line. The effects of AT1 receptor blocker candesartan were evaluated in a mouse model of peritoneal carcinomatosis. AT1 receptor protein was expressed in gastric cancer cell lines and tissues. Angiotensin II concentration in tumor region (1447 +/- 624 pg/g wet) was significantly higher than those of normal region (775 +/- 320 pg/g wet) (p&lt;0.05). Angiotensin II stimulates the cell proliferation in the AT1 receptor-positive OCUM2MD3 gastric cancer cell line and this proliferative effect of angiotensin II was inhibited by a specific AT1 receptor antagonist, candesartan. We also confirmed the angiotensin II stimulated ERK1/2, nuclear transcript factor-kappa B (NF-kappa B) and surviving activation, which are central molecules of cellular proliferation and survival in OCUM2MD3 cells. Candesartan significantly prolonged survival time in a mouse model of peritoneal carcinomatosis compared with control group (p=0.0.197, log-rank test). Our data provide in vivo evidence of intrinsic angiotensin II generating system in gastric cancer and indicate locally formed angiotensin II is involved in cellular proliferation and survival.

    DOI: 10.3892/ijo_00000287

    PubMed

  • Expression of ERas oncogene in gastric carcinoma. Reviewed

    Kaizaki R, Yashiro M, Shinto O, Yasuda K, Matsuzaki T, Sawada T, Hirakawa K

    Anticancer research   29 ( 6 )   2189 - 93   2009.06( ISSN:0250-7005

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    PubMed

  • A novel transforming growth factor \#946; receptor kinase inhibitor, A-77, prevents the peritoneal dissemination of scirrhous gastric carcinoma Reviewed

    Yashiro Masakazu, Kawajiri Hidemi, Shinto Osamu, Noda Satoru, Nshii Takafumi, Fuyuhiro Yuhiko, Kashiwagi Shinichiro, Node Manabu, Miyazono Kohei, Ohira Masaichi, Hirakawa Kosei

    CANCER RESEARCH   69   2009.05( ISSN:0008-5472

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  • c-Met inhibitor might be a promising molecular-targeted molecule against for CPT11-resistant cancer stem cells Reviewed

    Nishii Takafumi, Yashiro Masakazu, Tanaka Hiroaki, Inoue Toru, Yamada Nobuya, Yamashita Yoshito, Onoda Naoyoshi, Maeda Kiyoshi, Sawada Tetsuji, Nakata Bunzo, Nishiguchi Yukio, Kato Yasuyuki, Ohira Masaichi, Isihikawa Tetsuro, Hirakawa Kosei

    CANCER RESEARCH   69   2009.05( ISSN:0008-5472

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  • Hypoxic condition promotes the adhesion ability of gastric cancer cells to peritoneum Reviewed

    Noda Satoru, Yashiro Masakazu, Nshii Takafumi, Fuyuhiro Yuhiko, Kato Yukihiro, Kashiwagi Shinichiro, Ohira Masaichi, Node Manabu, Hirakawa Kosei

    CANCER RESEARCH   69   2009.05( ISSN:0008-5472

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  • Triple-negative breast cancers frequently show the reduction of E-cadherin expression Reviewed

    Kashiwagi Shinichiro, Yashiro Masakazu, Takashima Tsutomu, Nomura Shinya, Noda Satoru, Kawajiri Hidemi, Onoda Naoyoshi, Ishikawa Tetsuro, Hirakawa Kosei

    CANCER RESEARCH   69   2009.05( ISSN:0008-5472

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  • Myofibroblasts and Vimentin-positive cancer cells are associated with the poor prognosis in gastric carcinoma Reviewed

    Fuyuhiro Yuhiko, Yashiro Masakazu, Noda Satoru, Nishii Takafumi, Kato Yukihiro, Kashiwagi Shinichiro, Tanaka Hiroaki, Inoue Toru, Yamada Nobuya, Yamashita Yoshito, Maeda Kiyoshi, Onoda Naoyoshi, Sawada Tetsuji, Nakata Bunzo, Nishiguchi Yukio, Kato Yasuyuki, Ohira Masaichi, Ishikawa Tetsuro, Hirakawa Kosei

    CANCER RESEARCH   69   2009.05( ISSN:0008-5472

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  • SB-431542, transforming growth factor beta receptor, induces maturation of dendritic cells and enhances anti-tumor activities in vitro and in vivo Reviewed

    Tanaka Hiroaki, Yashiro Masakazu, Shintou Osamu, Kubo Naoshi, Muguruma Kazuya, Yamada Nobuya, Yamashita Yoshito, Maeda Kiyoshi, Onoda Naoyoshi, Sawada Tetsuji, Nishiguchi Yukio, Ohira Masaichi, Ishikawa Tetsuro, Hirakawa Kosei

    CANCER RESEARCH   69   2009.05( ISSN:0008-5472

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  • c-Met inhibitor might be a promising molecular-targeted molecule against for CPT11-resistant cancer stem cells Reviewed

    Nishii Takafumi, Yashiro Masakazu, Tanaka Hiroaki, Inoue Toru, Yamada Nobuya, Yamashita Yoshito, Onoda Naoyoshi, Maeda Kiyoshi, Sawada Tetsuji, Nakata Bunzo, Nishiguchi Yukio, Kato Yasuyuki, Ohira Masaichi, Isihikawa Tetsuro, Hirakawa Kosei

    CANCER RESEARCH   69   2009.05( ISSN:0008-5472

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  • Triple-negative breast cancers frequently show the reduction of E-cadherin expression Reviewed

    Kashiwagi Shinichiro, Yashiro Masakazu, Takashima Tsutomu, Nomura Shinya, Noda Satoru, Kawajiri Hidemi, Onoda Naoyoshi, Ishikawa Tetsuro, Hirakawa Kosei

    CANCER RESEARCH   69   2009.05( ISSN:0008-5472

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  • SB-431542, transforming growth factor beta receptor, induces maturation of dendritic cells and enhances anti-tumor activities in vitro and in vivo Reviewed

    Tanaka Hiroaki, Yashiro Masakazu, Shintou Osamu, Kubo Naoshi, Muguruma Kazuya, Yamada Nobuya, Yamashita Yoshito, Maeda Kiyoshi, Onoda Naoyoshi, Sawada Tetsuji, Nishiguchi Yukio, Ohira Masaichi, Ishikawa Tetsuro, Hirakawa Kosei

    CANCER RESEARCH   69   2009.05( ISSN:0008-5472

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  • Myofibroblasts and Vimentin-positive cancer cells are associated with the poor prognosis in gastric carcinoma Reviewed

    Fuyuhiro Yuhiko, Yashiro Masakazu, Noda Satoru, Nishii Takafumi, Kato Yukihiro, Kashiwagi Shinichiro, Tanaka Hiroaki, Inoue Toru, Yamada Nobuya, Yamashita Yoshito, Maeda Kiyoshi, Onoda Naoyoshi, Sawada Tetsuji, Nakata Bunzo, Nishiguchi Yukio, Kato Yasuyuki, Ohira Masaichi, Ishikawa Tetsuro, Hirakawa Kosei

    CANCER RESEARCH   69   2009.05( ISSN:0008-5472

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  • Diffuse-Type Gastric Carcinoma: Progression, Angiogenesis, and Transforming Growth Factor beta Signaling Reviewed

    Komuro Akiyoshi, Yashiro Masakazu, Iwata Caname, Morishita Yasuyuki, Johansson Erik, Matsumoto Yoshiko, Watanabe Akira, Aburatani Hiroyuki, Miyoshi Hiroyuki, Kiyono Kunihiko, Shirai Yo-taro, Suzuki Hiroshi I., Hirakawa Kosei, Kano Mitsunobu R., Miyazono Kohei

    JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE   101 ( 8 )   592 - 604   2009.04( ISSN:0027-8874

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    DOI: 10.1093/jnci/djp058

    PubMed

  • Co-expression of keratinocyte growth factor and K-sam is an independent prognostic factor in gastric carcinoma Reviewed

    Toyokawa Takahiro, Yashiro Masakazu, Hirakawa Kosei

    ONCOLOGY REPORTS   21 ( 4 )   875 - 880   2009.04( ISSN:1021-335X

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    DOI: 10.3892/or_00000297

    PubMed

  • Co-expression of keratinocyte growth factor and K-sam is an independent prognostic factor in gastric carcinoma Reviewed

    Takahiro Toyokawa, Masakazu Yashiro, Kosei Hirakawa

    ONCOLOGY REPORTS   21 ( 4 )   875 - 80   2009.04( ISSN:1021-335X

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    Keratinocyte growth factor (KGF) from gastric fibroblasts have been reported to stimulate proliferation of scirrhous gastric cancer cells with K-samII amplification in a paracrine manner. The aim of this study was to evaluate the clinical significance of the co-expression of K-sam and KGF in gastric carcinomas. A total of 136 primary gastric tumors were investigated by staining with antibodies against K-sam and KGF. K-sam expression on cancer cells and KGF expression on fibroblasts was estimated. The relationship between the K-sam and/or KGF expression and the clinicopathological characteristics were analyzed. K-sam expression was positive in 42 (31%) of 136 gastric carcinomas. K-sam expression was positively correlated with scirrhous cancer (p&lt;0.001), diffuse type (p=0.031), invasion depth (p=0.018) and infiltration type (p&lt;0.001). Prognosis of K-sam positive patients was significantly poorer than that of K-sam negative patients (p&lt;0.001). The prognosis of patients with both K-sam and KGF positive tumors was significantly worse in comparison to either negative tumors (p&lt;0.001). In 94 patients with a curative resection, a multivariate analysis revealed the co-expression of K-sam and KGF to be an independent prognostic factor (p=0.029). In conclusion, the co-expression of K-sam and KGF in gastric cancer might be a useful prognostic factor.

    DOI: 10.3892/or_00000297

    PubMed

  • Diffuse-Type Gastric Carcinoma: Progression, Angiogenesis, and Transforming Growth Factor beta Signaling Reviewed

    Akiyoshi Komuro, Masakazu Yashiro, Caname Iwata, Yasuyuki Morishita, Erik Johansson, Yoshiko Matsumoto, Akira Watanabe, Hiroyuki Aburatani, Hiroyuki Miyoshi, Kunihiko Kiyono, Yo-taro Shirai, Hiroshi I. Suzuki, Kosei Hirakawa, Mitsunobu R. Kano, Kohei Miyazono

    JOURNAL OF THE NATIONAL CANCER INSTITUTE   101 ( 8 )   592 - 604   2009.04( ISSN:0027-8874 ( eISSN:1460-2105

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    Diffuse-type gastric carcinoma is a cancer with poor prognosis that has high levels of transforming growth factor beta (TGF-beta) expression and thick stromal fibrosis. However, the association of TGF-beta signaling with diffuse-type gastric carcinoma has not been investigated in detail.
    We used a lentiviral infection system to express a dominant-negative TGF-beta type II receptor (dnT beta RII) or green fluorescent protein (GFP) as a control in the diffuse-type gastric carcinoma cell lines, OCUM-2MLN and OCUM-12. These infected cells and the corresponding parental control cells were subcutaneously or orthotopically injected into nude mice. Angiogenesis was inhibited by infecting cells with a lentivirus carrying the gene for angiogenic inhibitor thrombospondin-1 or by injecting mice intraperitoneally with the small-molecule angiogenic inhibitor sorafenib or with anti-vascular endothelial growth factor (VEGF) neutralizing antibody (six or eight mice per group). Expression of phospho-Smad2 and thrombospondin-1 was investigated immunologically in human gastric carcinoma tissues from 102 patients. All statistical tests were two-sided.
    Expression of dnT beta RII into OCUM-2MLN cells did not affect their proliferation in vitro, but it accelerated the growth of subcutaneously or orthotopically transplanted tumors in vivo (eg, for mean volume of subcutaneous tumors on day 10 relative to that on day 0: dnT beta RII tumors = 3.49 and GFP tumors = 2.46, difference = 1.02, 95% confidence interval [CI] = 0.21 to 1.84; P = .003). The tumors expressing dnT beta RII had higher levels of angiogenesis than those expressing GFP because of decreased thrombospondin-1 production. Similar results were obtained with OCUM-12 cells. Expression of thrombospondin-1 in the dnT beta RII tumor or treatment with sorafenib or anti-VEGF antibody reduced tumor growth, whereas knockdown of thrombospondin-1 expression resulted in more accelerated growth of OCUM-2MLN tumors than of GFP tumors (eg, mean tumor volumes on day 14 relative to those on day 0: thrombospondin-1-knockdown tumors = 4.91 and GFP tumors = 3.79, difference = 1.12, 95% CI = 0.80 to 1.44; P &lt; .001). Positive association between phosphorylated Smad2 and thrombospondin-1 immunostaining was observed in human gastric carcinoma tissues.
    Disruption of TGF-beta signaling in diffuse-type gastric carcinoma models appeared to accelerate tumor growth, apparently through increased tumor angiogenesis that was induced by decreased expression of thrombospondin-1.

    DOI: 10.1093/jnci/djp058

    PubMed

  • HP-012-5 高齢者胃癌切除症例における術後合併症の特徴(胃(臨床1),ハイブリッドポスター,第109回日本外科学会定期学術集会) Reviewed

    豊川 貴弘, 六車 一哉, 山下 好人, 久保 尚士, 八代 正和, 澤田 鉄二, 西口 幸雄, 大平 雅一, 石川 哲郎, 平川 弘聖

    一般社団法人日本外科学会 日本外科学会雑誌   110 ( 2 )   2009.02( ISSN:03014894

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  • HP-219-6 膵管癌におけるHER 2発現の検討(膵(臨床7),ハイブリッドポスター,第109回日本外科学会定期学術集会) Reviewed

    河本 真大, 仲田 文造, 天野 良亮, 山田 靖哉, 八代 正和, 石川 哲郎, 平川 弘聖

    一般社団法人日本外科学会 日本外科学会雑誌   110 ( 2 )   2009.02( ISSN:03014894

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  • HP-208-5 PSKとTGFbeta阻害剤の併用による癌宿主の免疫応答増強効果(免疫・分子標的治療,ハイブリッドポスター,第109回日本外科学会定期学術集会) Reviewed

    田中 浩明, 八代 正和, 野田 英児, 天野 良亮, 久保 尚士, 六車 一哉, 井上 透, 山田 靖哉, 前田 清, 小野田 尚佳, 澤田 鉄二, 仲田 文造, 大平 雅一, 石川 哲郎, 平川 弘聖

    一般社団法人日本外科学会 日本外科学会雑誌   110 ( 2 )   2009.02( ISSN:03014894

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  • HP-156-2 難治性乳癌(トリプルネガティブ)におけるE-cadherin発現(乳がん(トリプルネガティブ),ハイブリッドポスター,第109回日本外科学会定期学術集会) Reviewed

    柏木 伸一郎, 八代 正和, 高島 勉, 埜村 真也, 野田 諭, 川尻 成美, 小野田 尚佳, 仲田 文造, 石川 哲郎, 平川 弘聖

    一般社団法人日本外科学会 日本外科学会雑誌   110 ( 2 )   2009.02( ISSN:03014894

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  • HP-147-3 MUC 5 ACムチン強発現による膵癌細胞の接着・浸潤亢進のメカニズム(膵(浸潤・転移・血管新生),ハイブリッドポスター,第109回日本外科学会定期学術集会) Reviewed

    山添 定明, 田中 浩明, 澤田 鉄二, 久保 尚士, 六車 一哉, 高島 勉, 井上 透, 山田 靖哉, 八代 正和, 前田 清, 仲田 文造, 大平 雅一, 石川 哲郎, 平川 弘聖

    一般社団法人日本外科学会 日本外科学会雑誌   110 ( 2 )   2009.02( ISSN:03014894

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  • HP-090-3 TGF-β受容体阻害剤が胃癌浸潤転移におよぼす影響(胃(分子標的・免疫療法),ハイブリッドポスター,第109回日本外科学会定期学術集会) Reviewed

    神藤 理, 八代 正和, 川尻 成美, 清水 清, 清水 寿通, 宮園 浩平, 平川 弘聖

    一般社団法人日本外科学会 日本外科学会雑誌   110 ( 2 )   2009.02( ISSN:03014894

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  • HP-084-3 マルチキナーゼ阻害剤は低酸素環境における胃癌細胞の抗癌剤感受性を増強させる(胃(発癌・悪性度),ハイブリッドポスター,第109回日本外科学会定期学術集会) Reviewed

    野田 諭, 八代 正和, 井上 透, 山田 靖哉, 前田 清, 澤田 鉄二, 仲田 文造, 大平 雅一, 石川 哲郎, 平川 弘聖

    一般社団法人日本外科学会 日本外科学会雑誌   110 ( 2 )   2009.02( ISSN:03014894

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  • HP-067-6 膵癌外科治療における補助化学療法としてのGEM,TS-1の役割(膵(GEM,TS-1 2),ハイブリッドポスター,第109回日本外科学会定期学術集会) Reviewed

    天野 良亮, 山田 靖哉, 土井 洋輔, 西居 孝文, 河本 真大, 野田 英児, 久保 尚士, 田中 浩明, 六車 一哉, 高島 勉, 井上 透, 山下 好人, 八代 正和, 小野田 尚佳, 前田 清, 澤田 鉄二, 西口 幸雄, 仲田 文造, 大平 雅一, 石川 哲郎, 平川 弘聖

    一般社団法人日本外科学会 日本外科学会雑誌   110 ( 2 )   2009.02( ISSN:03014894

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  • HP-018-7 cStage II, III食道癌症例の術後再発に及ぼす因子(食道(手術,CRT),ハイブリッドポスター,第109回日本外科学会定期学術集会) Reviewed

    大平 雅一, 田中 浩明, 久保 尚士, 山下 好人, 六車 一哉, 野田 英児, 天野 良亮, 井上 透, 山田 靖哉, 八代 正和, 前田 清, 石川 哲郎, 平川 弘聖

    一般社団法人日本外科学会 日本外科学会雑誌   110 ( 2 )   2009.02( ISSN:03014894

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  • VS-014-1 当科における腹腔鏡補助下胃全摘術(LATG)および噴門側胃切除術後(LAPG)の器械的食道空腸吻合法の変遷(胃3,ビデオセッション,第109回日本外科学会定期学術集会) Reviewed

    六車 一哉, 豊川 貴弘, 山下 好人, 久保 尚士, 田中 浩明, 山田 靖哉, 八代 正和, 澤田 鉄二, 大平 雅一, 石川 哲郎, 平川 弘聖

    一般社団法人日本外科学会 日本外科学会雑誌   110 ( 2 )   2009.02( ISSN:03014894

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  • SF-111-3 胃癌細胞株におけるバルプロ酸ナトリウムの抗腫瘍効果の検討(分子標的・遺伝子治療1,サージカルフォーラム,第109回日本外科学会定期学術集会) Reviewed

    八木 康道, 伏田 幸夫, 柄田 智也, 尾山 勝信, 藤田 秀人, 二宮 致, 藤村 隆, 萱原 正都, 太田 哲生, 八代 正和, 平川 弘聖

    一般社団法人日本外科学会 日本外科学会雑誌   110 ( 2 )   2009.02( ISSN:03014894

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  • SF-029-5 胃癌微小環境における筋線維芽細胞の意義(胃癌(基礎研究1),サージカルフォーラム,第109回日本外科学会定期学術集会) Reviewed

    冬廣 雄彦, 八代 正和, 野田 諭, 加藤 幸裕, 神藤 理, 井上 透, 澤田 鉄二, 大平 雅一, 石川 哲郎, 平川 弘聖

    一般社団法人日本外科学会 日本外科学会雑誌   110 ( 2 )   2009.02( ISSN:03014894

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  • RSF-020-4 胃瘻,回腸人工肛門および腸瘻造設によりQOLを改善させた特発性偽性腸閉塞の一例(下部消化管(その他),研修医の発表セッション,第109回日本外科学会定期学術集会) Reviewed

    中尾 重富, 井上 透, 貝崎 亮二, 野田 英児, 前田 清, 久保 尚士, 田中 浩明, 六車 一哉, 山下 好人, 山田 靖哉, 八代 正和, 西口 幸雄, 澤田 鉄二, 大平 雅一, 平川 弘聖

    一般社団法人日本外科学会 日本外科学会雑誌   110 ( 2 )   2009.02( ISSN:03014894

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  • VSY-4-1 鏡視下手術を安全に行うための手技と工夫(鏡視下食道癌手術を安全に行うための手技と工夫,ビデオシンポジウム,第109回日本外科学会定期学術集会) Reviewed

    久保 尚士, 田中 浩明, 大平 雅一, 山下 好人, 豊川 貴弘, 野田 諭, 森本 純也, 天野 良亮, 野田 英児, 六車 一哉, 井上 透, 高島 勉, 山田 靖哉, 八代 正和, 前田 清, 小野田 尚佳, 仲田 文造, 澤田 鉄二, 石川 哲郎, 平川 弘聖

    一般社団法人日本外科学会 日本外科学会雑誌   110 ( 2 )   2009.02( ISSN:03014894

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  • HP-012-5 高齢者胃癌切除症例における術後合併症の特徴(胃(臨床1),ハイブリッドポスター,第109回日本外科学会定期学術集会) Reviewed

    豊川 貴弘, 六車 一哉, 山下 好人, 久保 尚士, 八代 正和, 澤田 鉄二, 西口 幸雄, 大平 雅一, 石川 哲郎, 平川 弘聖

    日本外科学会雑誌   110 ( 2 )   417   2009.02( ISSN:03014894

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  • HP-219-6 膵管癌におけるHER 2発現の検討(膵(臨床7),ハイブリッドポスター,第109回日本外科学会定期学術集会) Reviewed

    河本 真大, 仲田 文造, 天野 良亮, 山田 靖哉, 八代 正和, 石川 哲郎, 平川 弘聖

    日本外科学会雑誌   110 ( 2 )   757   2009.02( ISSN:03014894

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  • HP-208-5 PSKとTGFbeta阻害剤の併用による癌宿主の免疫応答増強効果(免疫・分子標的治療,ハイブリッドポスター,第109回日本外科学会定期学術集会) Reviewed

    田中 浩明, 八代 正和, 野田 英児, 天野 良亮, 久保 尚士, 六車 一哉, 井上 透, 山田 靖哉, 前田 清, 小野田 尚佳, 澤田 鉄二, 仲田 文造, 大平 雅一, 石川 哲郎, 平川 弘聖

    日本外科学会雑誌   110 ( 2 )   739   2009.02( ISSN:03014894

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  • HP-156-2 難治性乳癌(トリプルネガティブ)におけるE-cadherin発現(乳がん(トリプルネガティブ),ハイブリッドポスター,第109回日本外科学会定期学術集会) Reviewed

    柏木 伸一郎, 八代 正和, 高島 勉, 埜村 真也, 野田 諭, 川尻 成美, 小野田 尚佳, 仲田 文造, 石川 哲郎, 平川 弘聖

    日本外科学会雑誌   110 ( 2 )   658   2009.02( ISSN:03014894

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  • HP-147-3 MUC 5 ACムチン強発現による膵癌細胞の接着・浸潤亢進のメカニズム(膵(浸潤・転移・血管新生),ハイブリッドポスター,第109回日本外科学会定期学術集会) Reviewed

    山添 定明, 田中 浩明, 澤田 鉄二, 久保 尚士, 六車 一哉, 高島 勉, 井上 透, 山田 靖哉, 八代 正和, 前田 清, 仲田 文造, 大平 雅一, 石川 哲郎, 平川 弘聖

    日本外科学会雑誌   110 ( 2 )   645   2009.02( ISSN:03014894

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  • HP-090-3 TGF-β受容体阻害剤が胃癌浸潤転移におよぼす影響(胃(分子標的・免疫療法),ハイブリッドポスター,第109回日本外科学会定期学術集会) Reviewed

    神藤 理, 八代 正和, 川尻 成美, 清水 清, 清水 寿通, 宮園 浩平, 平川 弘聖

    日本外科学会雑誌   110 ( 2 )   548   2009.02( ISSN:03014894

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  • HP-084-3 マルチキナーゼ阻害剤は低酸素環境における胃癌細胞の抗癌剤感受性を増強させる(胃(発癌・悪性度),ハイブリッドポスター,第109回日本外科学会定期学術集会) Reviewed

    野田 諭, 八代 正和, 井上 透, 山田 靖哉, 前田 清, 澤田 鉄二, 仲田 文造, 大平 雅一, 石川 哲郎, 平川 弘聖

    日本外科学会雑誌   110 ( 2 )   538   2009.02( ISSN:03014894

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  • HP-067-6 膵癌外科治療における補助化学療法としてのGEM,TS-1の役割(膵(GEM,TS-1 2),ハイブリッドポスター,第109回日本外科学会定期学術集会) Reviewed

    天野 良亮, 山田 靖哉, 土井 洋輔, 西居 孝文, 河本 真大, 野田 英児, 久保 尚士, 田中 浩明, 六車 一哉, 高島 勉, 井上 透, 山下 好人, 八代 正和, 小野田 尚佳, 前田 清, 澤田 鉄二, 西口 幸雄, 仲田 文造, 大平 雅一, 石川 哲郎, 平川 弘聖

    日本外科学会雑誌   110 ( 2 )   509   2009.02( ISSN:03014894

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  • HP-018-7 cStage II, III食道癌症例の術後再発に及ぼす因子(食道(手術,CRT),ハイブリッドポスター,第109回日本外科学会定期学術集会) Reviewed

    大平 雅一, 田中 浩明, 久保 尚士, 山下 好人, 六車 一哉, 野田 英児, 天野 良亮, 井上 透, 山田 靖哉, 八代 正和, 前田 清, 石川 哲郎, 平川 弘聖

    日本外科学会雑誌   110 ( 2 )   427   2009.02( ISSN:03014894

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  • RSF-020-4 胃瘻,回腸人工肛門および腸瘻造設によりQOLを改善させた特発性偽性腸閉塞の一例(下部消化管(その他),研修医の発表セッション,第109回日本外科学会定期学術集会) Reviewed

    中尾 重富, 井上 透, 貝崎 亮二, 野田 英児, 前田 清, 久保 尚士, 田中 浩明, 六車 一哉, 山下 好人, 山田 靖哉, 八代 正和, 西口 幸雄, 澤田 鉄二, 大平 雅一, 平川 弘聖

    日本外科学会雑誌   110 ( 2 )   817   2009.02( ISSN:03014894

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  • VSY-4-1 鏡視下手術を安全に行うための手技と工夫(鏡視下食道癌手術を安全に行うための手技と工夫,ビデオシンポジウム,第109回日本外科学会定期学術集会) Reviewed

    久保 尚士, 田中 浩明, 大平 雅一, 山下 好人, 豊川 貴弘, 野田 諭, 森本 純也, 天野 良亮, 野田 英児, 六車 一哉, 井上 透, 高島 勉, 山田 靖哉, 八代 正和, 前田 清, 小野田 尚佳, 仲田 文造, 澤田 鉄二, 石川 哲郎, 平川 弘聖

    日本外科学会雑誌   110 ( 2 )   118   2009.02( ISSN:03014894

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  • VS-014-1 当科における腹腔鏡補助下胃全摘術(LATG)および噴門側胃切除術後(LAPG)の器械的食道空腸吻合法の変遷(胃3,ビデオセッション,第109回日本外科学会定期学術集会) Reviewed

    六車 一哉, 豊川 貴弘, 山下 好人, 久保 尚士, 田中 浩明, 山田 靖哉, 八代 正和, 澤田 鉄二, 大平 雅一, 石川 哲郎, 平川 弘聖

    日本外科学会雑誌   110 ( 2 )   384   2009.02( ISSN:03014894

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  • SF-111-3 胃癌細胞株におけるバルプロ酸ナトリウムの抗腫瘍効果の検討(分子標的・遺伝子治療1,サージカルフォーラム,第109回日本外科学会定期学術集会) Reviewed

    八木 康道, 伏田 幸夫, 柄田 智也, 尾山 勝信, 藤田 秀人, 二宮 致, 藤村 隆, 萱原 正都, 太田 哲生, 八代 正和, 平川 弘聖

    日本外科学会雑誌   110 ( 2 )   363   2009.02( ISSN:03014894

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  • SF-029-5 胃癌微小環境における筋線維芽細胞の意義(胃癌(基礎研究1),サージカルフォーラム,第109回日本外科学会定期学術集会) Reviewed

    冬廣 雄彦, 八代 正和, 野田 諭, 加藤 幸裕, 神藤 理, 井上 透, 澤田 鉄二, 大平 雅一, 石川 哲郎, 平川 弘聖

    日本外科学会雑誌   110 ( 2 )   260   2009.02( ISSN:03014894

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  • DNA methyltransferase inhibitor 5-aza-CdR enhances the radiosensitivity of gastric cancer cells Reviewed

    QIU Hong, YASHIRO Masakazu, SHINTO Osamu, MATSUZAKI Taro, HIRAKAWA Kosei

    Cancer science   100 ( 1 )   181 - 188   2009.01( ISSN:13479032

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  • DNA methyltransferase inhibitor 5-aza-CdR enhances the radiosensitivity of gastric cancer cells Reviewed

    QIU Hong, YASHIRO Masakazu, SHINTO Osamu, MATSUZAKI Taro, HIRAKAWA Kosei

    Cancer Sci   100 ( 1 )   181 - 188   2009.01( ISSN:13479032

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  • DNA methyltransferase inhibitor 5-aza-CdR enhances the radiosensitivity of gastric cancer cells Reviewed

    Qiu Hong, Yashiro Masakazu, Shinto Osamu, Matsuzaki Taro, Hirakawa Kosei

    CANCER SCIENCE   100 ( 1 )   181 - 188   2009.01( ISSN:1349-7006

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    DOI: 10.1111/j.1349-7006.2008.01004.x

    PubMed

  • DNA methyltransferase inhibitor 5-aza-CdR enhances the radiosensitivity of gastric cancer cells Reviewed

    Hong Qiu, Masakazu Yashiro, Osamu Shinto, Taro Matsuzaki, Kosei Hirakawa

    CANCER SCIENCE   100 ( 1 )   181 - 8   2009.01( ISSN:1347-9032

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    The National Comprehensive Cancer Network guidelines recommend radiotherapy as a standard treatment for patients with a high risk of recurrence in gastric cancer. Because radiation is harmful to the surrounding organs, a radiation sensitizer might therefore be useful to decrease the side effects of patients with advanced gastric carcinoma. The aim of the current study was to clarify the effect of a DNA methyltransferase inhibitor, 5-aza-2&apos;-deoxycytidine (CdR), on radiation sensitivity in gastric cancer cells. Five gastric cancer cell lines, OCUM-2M, OCUM-12, KATO-III, MKN-45, and MKN-74, were used. The effects of 5-aza-CdR with irradiation on the growth activity, cell-cycle distribution, apoptosis, and apoptosis-associated gene expression were examined. 5-aza-CdR sensitized three of five gastric cancer cell lines to radiation. A combination of irradiation and 5-aza-CdR significantly (P &lt; 0.05) decreased the growth activity compared with irradiation alone in OCUM-2M, OCUM-12, and MKN-45 cells, but not in KATO-III and MKN-74 cells. The percentage of cells in G(2)-M phase and the apoptotic rate with irradiation in combination with 5-aza-CdR were increased in OCUM-2M, OCUM-12, and MKN-45 cells compared with irradiation alone, but not in KATO-III and MKN-74 cells. 5-aza-CdR increased the expression of p53, RASSF1, and death-associated protein kinases (DAPK) genes compared with the control or irradiation alone. These findings suggest that 5-aza-CdR might therefore be useful as a radiation sensitizer to treat some types of gastric carcinoma. The arrest at G(2)-M phase and increased apoptotic rate might be partly mediated by enhanced expression of the p53, RASSF1, or DAPK gene families by 5-aza-CdR. (Cancer Sci 2009; 100: 181-188).

    DOI: 10.1111/j.1349-7006.2008.01004.x

    PubMed

  • Diffuse-type gastric carcinoma: progression, angiogenesis, and transforming growth factor beta signaling.

    J Natl Cancer Inst   101   592   2009

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  • Effects of VEGFR-3 phosphorylation inhibitor on lymph node metastasis in an orthotopic diffuse-type gastric carcinoma model. Reviewed

    Br J Cancer   101   1100   2009

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  • Synergistic antitumor effects of FGFR2 inhibitor with 5-fluorouracil on scirrhous gastric carcinoma.

    Int J Cancer   121   2009

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  • Allelic imbalance at p53 and microsatellite instability are predictive markers for resistance to chemotherapy in gastric carcinoma.

    Ann Surg Oncol   19   2926   2009

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  • ERas oncogene, a novel molecular tumor marker for early gastric carcinoma Reviewed

    Kaizaki Ryoji, Hirakawa Kosei, Yashiro Masakazu, Shinto Osamu, Yasuda Koichi, Matsuzaki Taro, Tanaka Hiroaki, Sawada Tetsuji, Nakata Bunzo, Ohira Masaichi

    Japanese Society for Molecular Tumor Marker Research, Japan Journal of Molecular Tumor Marker Research   ( 24 )   14 - 15   2009

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    DOI: 10.11241/jsmtmr.24.14

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  • Impact of MUC5AC mucin on pancratic cancer cell line Reviewed

    Yamazoe Sadaaki, Maeda Kiyoshi, Nakata Bunzo, Ohira Masaichi, Ishikawa Tetsuro, Hirakawa Kosei, Tanaka Hiroaki, Sawada Tetsuji, Kubo N, Muguruma Kazuya, Takashima T, Inoue Toru, Yamada Nobuya, Yashiro Masakazu

    Japanese Society for Molecular Tumor Marker Research, Japan Journal of Molecular Tumor Marker Research   ( 24 )   18 - 18   2009

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    DOI: 10.11241/jsmtmr.24.18

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  • Impacts of PSK and TβR inhibitor on immune response in immunosuppressive status associated with cancer Reviewed

    Hiroaki Tanaka, Sadaaki Yamazoe, Takehiko Iwauchi, Naoshi Kubo, Kazuya Muguruma, Masakazu Yashiro, Nobuya Yamada, Tetsuji Sawada, Masaichi Ohira, Kosei Hirakawa

    Japanese Journal of Cancer and Chemotherapy   36 ( 12 )   1969 - 1971   2009( ISSN:0385-0684

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    Secretion of the transforming growth factor-β (TGF-β) by tumor cells suppresses an antitumor immune response in which dendritic cells (DCs) play an important role to activate cytotoxic T lymphocytes (CTLs). Here we report that small molecule TGF-v signaling inhibitor, SB-431542, induces DC maturation in vitro when combined with protein-bound polysaccharide K (PSK). PSK has been used clinically as an anti-tumor agent in Japan, In this study, we examined the impact of PSK and SB-431542 on maturation of DCs under immunological tolerant status. At first, we added SB and PSK to cultures of human DCs generated from peripheral monocytes in the presence of TGF-/? and examined expression of CD83, production of Interleukin-12 (IL-12) and capacity of DCs to induce T cell proliferation. SB-431542 with PSK induced up regulation of CD83 expression of DCs and improved their abilities to produce IL-12. They also augmented the capacity of DCs to activate naïve T cells in allogeneic mixed lymphocyte reaction. These results suggested that PSK with TGF-β receptor I kinase inhibitor should be able to induce antitumor immune response in immune-tolerant patients associated with TGF-β activity.

    PubMed

  • A case of advanced esophageal cancer with para-aortic lymph node metastasis with complete response (CR) to combination chemotherapy including nedaplatin Reviewed

    Satoru Noda, Naoshi Kubo, Hiroaki Tanaka, Kazuya Muguruma, Masakazu Yashiro, Nobuya Yamada, Kiyoshi Maeda, Tetsuji Sawada, Masaichi Ohira, Tetsuro Ishikawa, Kosei Hirakawa

    Japanese Journal of Cancer and Chemotherapy   36 ( 12 )   2451 - 2453   2009( ISSN:0385-0684

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    The patient was a 55-year-old male, who was diagnosed to have a middle thoracic esophageal squamous cell carcinoma with para-aortic lymph node metastasis. The clinical stage diagnosis was T3N4M1, stage IVb, non-resectable esophageal SCC. Systemic chemotherapy with low-dose nedaplatin/5-FU treatment was started as the initial treatment. After three courses, para-aortic lymph node metastasis was not found by CT scan, and we added radiation therapy. After radiation therapy by 45 Gy, primary lesion and mediasternal lymph node metastasis were not shown by endoscopy and CT scan. We detected an increase of tumor marker after the observation for six months without any treatment, and then we started docetaxel/nedaplatin treatment as secondary chemotherapy. After ten courses, the tumor marker was decreased, and the patient is still in a stable disease state. We concluded that FGP therapy and DGP therapy were a veryeffective treatment for advanced esophageal SCC.

    PubMed

  • スキルス胃癌の病態に基づいた分子標的治療TGFβレセプター阻害剤による腹膜転移抑制 消化器疾患と分子標的薬 Reviewed

    八代 正和

    癌の臨床 55(1)   81 - 90   2009

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  • Results of neo-adjuvant chemotherapy by FOLFOX and FOLFIRI for colorectal liver metastasis Reviewed

    Ryosuke Amano, Nobuya Yamada, Eiji Noda, Naoshi Kubo, Hiroaki Tanaka, Kazuya Muguruma, Toru Inoue, Masakazu Yashiro, Kiyoshi Maeda, Naoyoshi Onoda, Tetsuji Sawada, Bunzo Nakata, Masaichi Ohira, Tetsuro Ishikawa, Kosei Hirakawa

    Japanese Journal of Cancer and Chemotherapy   36 ( 12 )   2003 - 2005   2009( ISSN:0385-0684

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    We analyzed a treatment outcome and the effect of FOLFOX and FOLFIRI neo-adjuvant chemotherapy (NAC) for patient with liver metastasis of colorectal cancer. Eleven patients undergoing hepatectomy after NAC were investigated. FOLFOX was performed for 8 patients, and FOLFIRI was for 3 patients. The response rate was 45.5% (PR 5, SD 6), and the reduction rate was 37.7%. The average ICG R15 value before hepatectomy was 13.7%. A complication during and after operations was not recognized. The average observation period was 19.8 months (8-45 months). Now, 9 patients are alive with no recurrence. NAC by FOLFOX for liver metastasis of colorectal cancer showed a high reduction rate, and there was a little influence to hepatectomy indicating that FOLFOX could be an effective therapy.

    PubMed

  • Concurrent chemoradiotherapy with nedaplatin and 5-fluorouracil (5-FU) for locally advanced squamous cell carcinoma of the esophagus Reviewed

    Naoshi Kubo, Junya Morimoto, Hiroaki Tanaka, Masaichi Ohira, Eiji Noda, Ryosuke Amano, Toru Inoue, Nobuya Yamada, Masakazu Yashiro, Kiyoshi Maeda, Yoshito Yamashita, Kazuya Muguruma, Tetsuji Sawada, Kosei Hirakawa

    Japanese Journal of Cancer and Chemotherapy   36 ( 12 )   1997 - 1999   2009( ISSN:0385-0684

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    Background: Concurrent chemoradiotherapy (CRT) using cisplatin (CDDP) and 5-fluorouracil (5-FU) is the standard treatment for unresectable locally advanced esophageal carcinoma. Although this regimen has been widely accepted in Japan, the adverse effect of CDDP such as gastrointestinal and renal toxicity may sometimes be the cause of interruption of the treatment, especially among the elderly patients. Cis-diammine-glycolatoplatinum (nedaplatin: CDGP) is a new platinum agent, which was developed with the aim of decreasing renal and gastrointestinal toxicities but maintaining the effectiveness of CDDP. We reported the efficacy and safety of CRT using CDGP and 5-FU for locally advanced squamous cell carcinoma of the esopahagus. Patients and methods: Between January 2001 and December 2007, 65 patients with locally advanced esophageal cancer (39 patients with unresectable tumor (cT4) and 26 patients with distant lymphnode or bulkey lymphnode metastasis) were eligible and given informed consent and cared by the Department of Surgical Oncology of Osaka City University. Patients received a continuous infusion of 5-FU (250 mg/body) on days 1-21. CDGP was administered at the dose of 10 mg, body by bolus infusion for 1 hour on days 1-5, 8-12 and 15-19 just before radiotherapy. Radiotherapy was delivered in 1.8 Gy fractions, 5 days week for 4 weeks. For the effective cases of CRT, a surgical resection was followed subsequently and an additional radiotherapy at the dose of 20 Gy was performed for non-effective cases. Results: Complete or partial response was achieved in 46 patients (71 %). Hematologic toxicities such as grades 3 and 4 leucocytopenia developed in 19 patients and thrombocytopenia developed in 20 patients, which were well tolerated by conservative therapy. Gastrointestinal and renal toxicities were developed in only a few patients. There was no CRT-related death. Of all 65 patients, 25 patients underwent a surgical resection while 19 patients could receive a curative resection (R0 operation). In the resected cases, a 5-year survival rate and the median survival time were 27% and 22.5 months, respectively. Conclusion: Concurrent CRT with CDGP and 5-FU was effective and safe for locally advanced squamous cell carcinoma of the esophagus.

    PubMed

  • A case of stage IV advanced esophageal cancer with a long term survival by radiation therapy combined with nedaplatin and 5-FU chemotherapy Reviewed

    Junya Morimoto, Masaichi Oohira, Naoshi Kubo, Hiroaki Tanaka, Nobuhiro Dan, Kazuya Muguruma, Masakazu Yashiro, Tetsuji Sawada, Yoshito Yamashita, Yukio Nishiguchi, Kousei Hirakawa

    Japanese Journal of Cancer and Chemotherapy   36 ( 12 )   2436 - 2438   2009( ISSN:0385-0684

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    The patient was a 73-year-old man who complained of dysphagea. Various examinations revealed an esophageal cancer with direct invasion to the left main bronchus (cT4, N2 (104R, 106recR), MO, Stage IVa)-and gastric cancer (cT2, NO, MO, Stage IB). The patient was given preoperative chemoradiotherapy (40 Gy/20 fr with CDGP 10 mg/body day 1-5, 8-12, 15-19 and 5-FU 250 mg/body day 1-5, 8-12, 15-19). After the chemoradiotherapy, we estimated that the esophageal cancer was down stage (cT4 → T3), and that a curative operation was possible. Therefore, subtotal esophagectomy and partial gastrectomy were performed without a complication. Pathological therapeutic evaluation of the esophageal cancer was complete response (CR) and the gastric cancer was T2, NO. Adjuvant chemotherapy was undergone with S-1. However, two years after the first operation, we found a reccurence of gastric duct. Therefore a surgical resection for recurrence of gastric duct was performed. The patient is still alive without recurrence 5 years and 2 months after the first treatment. Radiation therapy combined with nedaplatin and 5-FU is a safe and effective method for treating cT4 advanced esophageal cancer.

    PubMed

  • Laparoscopic Surgery for Ulcerative Colitis-selection of Surgical Procedure According to the Degree of Emergency

    Maeda Kiyoshi, Noda Eiji, Inoue Toru, Oshitani Nobuhide, Watanabe Kennji, Yamagami Hirokazu, Kamata Noriko, Sogawa Mitue, Yashiro Masakazu, Yamada Nobuya, Nishiguchi Yukio, Ikehara Teruyuki, Hirakawa Kosei

    Nippon Daicho Komonbyo Gakkai Zasshi   62 ( 7 )   453 - 460   2009( ISSN:00471801 ( eISSN:18829619

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    We have performed laparo-assisted (LA-RPC) or hand-assisted laparoscopic (HALS) restorative proctocolectomy for elective patients with ulcerative colitis. For patients who need semi-emergency operation, we have performed HALS total colectomy. In this report, we investigate the propriety of these laparoscopic surgical procedures.<br> We compare the clinical outcomes between the 74 patients who underwent laparoscopic surgery form July 2001 to September 2008 and the 56 patients who underwent the conventional surgical procedure from 1997 to 2001.<br> As for the elective patients, although the operation time was longer in LA-RPC, the blood loss was significantly less and the length of hospital stay was significantly shorter in LA-RPC, compared with conventional laparotomy. Moreover, in the patients who underwent semi-emergency surgery, in the HALS group although the operation time was slightly longer the blood loss was significantly less and the length of hospital stay was significantly shorter.<br> In conclusion, further examination is necessary, but it is thought that especially for LA-RPC, although the operation time is longer, recovery after operation is quicker, and body appearance is better. HALS is considered to be a standard technique for semi-emergency operation, because the operation time is only slighly longer and recovery is quicker.<br>

    DOI: 10.3862/jcoloproctology.62.453

    CiNii Article

  • 臨牀消化器内科 Reviewed

    八代 正和

    24(2)   193 - 200   2009

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  • Impact of MUC5AC mucin on pancratic cancer cell line Reviewed

    Yamazoe Sadaaki, Tanaka Hiroaki, Sawada Tetsuji, Kubo N, Muguruma Kazuya, Takashima T, Inoue Toru, Yamada Nobuya, Yashiro Masakazu, Maeda Kiyoshi, Nakata Bunzo, Ohira Masaichi, Ishikawa Tetsuro, Hirakawa Kosei

    Japan Journal of Molecular Tumor Marker Research   24   18 - 18   2009( eISSN:24338575

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    DOI: 10.11241/jsmtmr.24.18

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  • ERas oncogene, a novel molecular tumor marker for early gastric carcinoma Reviewed

    Kaizaki Ryoji, Yashiro Masakazu, Shinto Osamu, Yasuda Koichi, Matsuzaki Taro, Tanaka Hiroaki, Sawada Tetsuji, Nakata Bunzo, Ohira Masaichi, Hirakawa Kosei

    Japan Journal of Molecular Tumor Marker Research   24   14 - 15   2009( eISSN:24338575

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    DOI: 10.11241/jsmtmr.24.14

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  • [Anti-VEGF therapy for peritoneal dissemination model of gastric cancer considering of pharmacokinetics]. Reviewed

    Yagi Y, Fushida S, Fujita H, Kinami S, Ninomiya I, Fujimura T, Kayahara M, Ohta T, Yashiro M, Hirakawa K

    Gan to kagaku ryoho. Cancer & chemotherapy   35 ( 12 )   2005 - 8   2008.11( ISSN:0385-0684

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    PubMed

  • [Anti-VEGF therapy for peritoneal dissemination model of gastric cancer considering of pharmacokinetics]. Reviewed

    Yagi Y, Fushida S, Fujita H, Kinami S, Ninomiya I, Fujimura T, Kayahara M, Ohta T, Yashiro M, Hirakawa K

    Gan to kagaku ryoho. Cancer & chemotherapy   35 ( 12 )   2005 - 2008   2008.11( ISSN:0385-0684

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    Vascular Endothelial Growth Factor (VEGF) plays an important role in proliferation of cancer cells, angiogenesis and vascular permeability in peritoneal dissemination. Now we investigated the efficacy of anti-VEGF therapy in peritoneal dissemination of gastric cancer considering of pharmacokinetics. We investigated pharmacokinetics of bevacizumab, humanized anti-VEGF monoclonal antibody in subcutaneous xenograft and peritoneal dissemination model of OCUM-2MD3, highly peritoneal-seeding cell line of human scirrhous gastric carcinoma. In the group of intraperitoneal administration, bevacizumab remains in the intraperitoneal cavity and transits slowly to blood pool. On the other hand, in the group of subcutaneous administration, bevacizumab transits faster to blood pool and is accumulated in subcutaneous tumors and peritoneal nodules. Bevacizumab administered intraperitoneally seemed to neutralize intraperitoneal VEGF. Bevacizumab administered in subcutaneous seemed to act on peritoneal wall and control vascular permeability. Systemic administration of anti-VEGF agent will be a potential therapy in peritoneal dissemination of gastric cancer.

    PubMed

  • Efficacy of S-1 for gastric cancer patients with positive peritoneal lavage cytology. Reviewed

    Ako E, Ohira M, Yamashita Y, Kubo N, Muguruma K, Yashiro M, Sawada T, Nakata B, Kato Y, Hirakawa K

    Hepato-gastroenterology   55 ( 86-87 )   1939 - 42   2008.09( ISSN:0172-6390

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  • Ulcerative colitis-associated colorectal cancer is frequently associated with the microsatellite instability pathway Reviewed

    Fujiwara Ichiro, Yashiro Masakazu, Kubo Naoshi, Maeda Kiyoshi, Hirakawa Kosei

    DISEASES OF THE COLON & RECTUM   51 ( 9 )   1387 - 1394   2008.09( ISSN:0012-3706

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    DOI: 10.1007/s10350-008-9212-9

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  • Efficacy of S-1 for Gastric Cancer Patients with Positive Peritoneal Lavage Cytology Reviewed

    Eiji Ako, Masaichi Ohira, Yoshito Yamashita, Naoshi Kubo, Kazuya Muguruma, Masakazu Yashiro, Tetsuji Sawada, Bunzo Nakata, Yasuyuki Kato, Kosei Hirakawa

    HEPATO-GASTROENTEROLOGY   55 ( 86-87 )   1939 - 1942   2008.09( ISSN:0172-6390

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    Background/Aims: Positive peritoneal lavage cytology (PLC) is a strong predictor of subsequent frank peritoneal dissemination. The prognosis for patients with positive PLC is as poor as with macroscopic peritoneal dissemination. We examined the clinical efficacy of S-1 chemotherapy against gastric cancer with positive PLC after macroscopically curative resection.
    Methodology: Among our gastric cancer patients proving to have positive PLC after operation, 17 treated between 2000 and 2005 and 20 treated between 1986 and 1.999 respectively represented S-1. and non-S-1. groups, between which we compared survival rates. S-1 was administered orally twice daily at a dose of 80mg/m(2)/day for 28 consecutive days followed by a 14-day pause, thus repeating the cycle every 6 weeks.
    Results: S-1 was administered for more than 2 cycles in all patients (median, 10 cycles). Grade 3 adverse reactions to S-1 occurred in two patients. Other adverse reactions were grade 2 or less. Cumulative survival in the S-1 group was better than in the non-S-1 group (p=0.0034), with 1- and 3-year survival rates of 87.5% and 71.6% vs. 59.0% and 17.1%.
    Conclusions: S-1 is effective as postoperative chemotherapy for gastric cancer patients with positive PLC after macroscopically curative resection.

    PubMed

  • Efficacy of S-1 for gastric cancer patients with positive peritoneal lavage cytology. Reviewed

    Ako E, Ohira M, Yamashita Y, Kubo N, Muguruma K, Yashiro M, Sawada T, Nakata B, Kato Y, Hirakawa K

    Hepato-gastroenterology   55 ( 86-87 )   1939 - 42   2008.09( ISSN:0172-6390

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  • Ulcerative colitis-associated colorectal cancer is frequently associated with the microsatellite instability pathway Reviewed

    Ichiro Fujiwara, Masakazu Yashiro, Naoshi Kubo, Kiyoshi Maeda, Kosei Hirakawa

    DISEASES OF THE COLON & RECTUM   51 ( 9 )   1387 - 94   2008.09( ISSN:0012-3706

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    PURPOSE: Patients with ulcerative colitis have a high risk for the development of colorectal cancer. To understand the molecular mechanisms of the carcinogenesis process of ulcerative colitis-associated colorectal cancer, the genetic alterations in inflamed or neoplastic colon epithelium in ulcerative colitis were analyzed.
    METHODS: Fifty-seven patients with ulcerative colitis were enrolled in this study. Specimens were obtained from the patients randomly at six colonic sites. Each patient was histologically classified according to the worst pathologic finding into cancer, dysplasia, indefinite, and normal cases. Microsatellite instability, mutations of target genes, hypermethylation of the hMLH1 promoter region, and mismatch repair protein expression were analyzed.
    RESULTS: High-microsatellite instability was found in 4 of 11 cancer cases (36 percent), 5 of 15 dysplasia cases (33 percent), 5 of 11 indefinite cases (45 percent), and none of 20 normal cases (0 percent). A significant correlation was found between the malignant potential and high-microsatellite instability. A frameshift mutation of transforming growth factor beta receptor Type II (TGF beta RII) was significantly correlated with worsening histologic grade. High-microsatellite instability was significantly associated with hMLH1 hypermethylation and loss of hMSH2 expression.
    CONCLUSION: The carcinogenesis process in ulcerative colitis-associated colorectal cancer was closely associated with the microsatellite instability pathway through TGF beta RII mutation by a dysfunction of the mismatch repair system.

    DOI: 10.1007/s10350-008-9212-9

    PubMed

  • 臨床病理カンファレンス 大腸癌 Reviewed

    八代 正和, 鰐渕 英機, 町田 浩久, 前田 清, 高田 佳江, 松田 常美, 仲田 文造, 田代 敬彦, 中村 肇, 天道 正成, 西原 承浩, 西野 裕二, 平川 弘聖, 上田 真喜子

    綜合臨床   57 ( 9 )   2396 - 2404   2008.09( ISSN:0371-1900

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  • O-1-226 低酸素耐性胃癌細胞株の樹立と転移能(基礎研究1,一般演題(口演),第63回日本消化器外科学会総会) Reviewed

    野田 諭, 八代 正和, 田中 浩明, 六車 一哉, 山田 靖哉, 澤田 鉄二, 仲田 文造, 大平 雅一, 石川 哲郎, 平川 弘聖

    一般社団法人日本消化器外科学会 日本消化器外科学会雑誌   41 ( 7 )   2008.07( ISSN:03869768

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  • RS-106 自動縫合器を用いた腹腔補助下幽門側胃切除術(LADG)後の消化管再建法について(要望演題5-2 自動縫合器を用いた胃切除後再建法の功罪2,第63回日本消化器外科学会総会) Reviewed

    六車 一哉, 澤田 鉄二, 豊川 貴弘, 久保 尚士, 田中 浩明, 八代 正和, 山田 靖哉, 山下 好人, 大平 雅一, 平川 弘聖

    一般社団法人日本消化器外科学会 日本消化器外科学会雑誌   41 ( 7 )   2008.07( ISSN:03869768

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  • P-2-491 潰瘍性大腸炎におけるVitamin D Receptor発現と大腸癌との関連性(炎症性腸疾患2,一般演題(ポスター),第63回日本消化器外科学会総会) Reviewed

    田中 浩明, 前田 清, 和田 光二, 久保 尚士, 六車 一哉, 八代 正和, 山田 靖哉, 澤田 鉄二, 大平 雅一, 平川 弘聖

    一般社団法人日本消化器外科学会 日本消化器外科学会雑誌   41 ( 7 )   2008.07( ISSN:03869768

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  • P-2-16 診断に難渋した多発性膵腫瘍の1例(胆・膵 症例3,一般演題(ポスター),第63回日本消化器外科学会総会) Reviewed

    土井 洋輔, 天野 良亮, 西居 孝文, 山田 靖哉, 八代 正和, 澤田 鉄二, 仲田 文造, 大平 雅一, 石川 哲郎, 平川 弘聖

    一般社団法人日本消化器外科学会 日本消化器外科学会雑誌   41 ( 7 )   2008.07( ISSN:03869768

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  • P-1-467 胃癌の浸潤・転移に対するTGF-β, TGF-β受容体阻害剤の作用について(胃 研究,一般演題(ポスター),第63回日本消化器外科学会総会) Reviewed

    神藤 理, 八代 正和, 川尻 成美, 清水 清, 清水 寿通, 宮園 浩平, 平川 弘聖

    一般社団法人日本消化器外科学会 日本消化器外科学会雑誌   41 ( 7 )   2008.07( ISSN:03869768

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  • O-2-87 分子標的治療薬mTOR阻害剤は5-FUの抗腫瘍効果を増強する(胃 研究2,一般演題(口演),第63回日本消化器外科学会総会) Reviewed

    松崎 太郎, 八代 正和, 田中 浩明, 井上 透, 山田 靖哉, 前田 清, 澤田 鉄二, 大平 雅一, 石川 哲郎, 平川 弘聖

    一般社団法人日本消化器外科学会 日本消化器外科学会雑誌   41 ( 7 )   2008.07( ISSN:03869768

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  • O-2-348 膵頭十二指腸切除術における膵空腸吻合の手技の工夫と成績(胆・膵 PD再建5,一般演題(口演),第63回日本消化器外科学会総会) Reviewed

    山田 靖哉, 天野 良亮, 西居 孝文, 土井 洋輔, 八代 正和, 澤田 鉄二, 仲田 文造, 大平 雅一, 石川 哲郎, 平川 弘聖

    一般社団法人日本消化器外科学会 日本消化器外科学会雑誌   41 ( 7 )   2008.07( ISSN:03869768

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  • O-2-319 原発性十二指腸癌切除例の検討(十二指腸,一般演題(口演),第63回日本消化器外科学会総会) Reviewed

    藤本 珠実, 天野 良亮, 山田 靖哉, 土井 洋輔, 西居 孝文, 八代 正和, 澤田 鉄二, 大平 雅一, 石川 哲郎, 平川 弘聖

    一般社団法人日本消化器外科学会 日本消化器外科学会雑誌   41 ( 7 )   2008.07( ISSN:03869768

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  • O-2-271 大腸低分化腺癌・粘液癌の検討(大腸 悪性3,一般演題(口演),第63回日本消化器外科学会総会) Reviewed

    檀 信浩, 前田 清, 井上 透, 野田 英児, 八代 正和, 山田 靖哉, 西口 幸雄, 大平 雅一, 石川 哲郎, 平川 弘聖

    一般社団法人日本消化器外科学会 日本消化器外科学会雑誌   41 ( 7 )   2008.07( ISSN:03869768

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  • O-2-23 術前化学療法が奏効した胃癌症例の検討(胃 化学療法4,一般演題(口演),第63回日本消化器外科学会総会) Reviewed

    貝崎 亮二, 六車 一哉, 豊川 貴弘, 久保 尚士, 八代 正和, 山下 好人, 澤田 鉄二, 大平 雅一, 石川 哲郎, 平川 弘聖

    一般社団法人日本消化器外科学会 日本消化器外科学会雑誌   41 ( 7 )   2008.07( ISSN:03869768

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  • O-2-185 高齢者(50歳以上)潰瘍性大腸炎の手術成績の検討(炎症性腸疾患1,一般演題(口演),第63回日本消化器外科学会総会) Reviewed

    井上 透, 前田 清, 野田 英児, 八代 正和, 埜村 真也, 山田 靖哉, 澤田 鉄二, 大平 雅一, 西口 幸雄, 平川 弘聖

    一般社団法人日本消化器外科学会 日本消化器外科学会雑誌   41 ( 7 )   2008.07( ISSN:03869768

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  • O-2-145 切除再建症例の臨床病理学的所見からみたT1a(MM)以深の胸部食道表在癌に対する治療戦略(食道 早期,一般演題(口演),第63回日本消化器外科学会総会) Reviewed

    大平 雅一, 久保 尚士, 田中 浩明, 山下 好人, 六車 一哉, 山田 靖哉, 八代 正和, 前田 清, 澤田 鉄二, 平川 弘聖

    一般社団法人日本消化器外科学会 日本消化器外科学会雑誌   41 ( 7 )   2008.07( ISSN:03869768

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  • O-1-98 膵癌細胞におけるMUC5ACムチンの機能解析(胆・膵 研究3,一般演題(口演),第63回日本消化器外科学会総会) Reviewed

    山添 定明, 田中 浩明, 澤田 鉄二, 山田 靖哉, 八代 正和, 前田 清, 仲田 文造, 大平 雅一, 石川 哲郎, 平川 弘聖

    一般社団法人日本消化器外科学会 日本消化器外科学会雑誌   41 ( 7 )   2008.07( ISSN:03869768

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  • O-1-228 癌幹細胞様SP細胞は抗癌剤耐性と腹膜転移に関与する(基礎研究1,一般演題(口演),第63回日本消化器外科学会総会) Reviewed

    西居 孝文, 八代 正和, 田中 浩明, 井上 透, 山田 靖哉, 山下 好人, 前田 清, 澤田 鉄二, 大平 雅一, 平川 弘聖

    一般社団法人日本消化器外科学会 日本消化器外科学会雑誌   41 ( 7 )   2008.07( ISSN:03869768

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  • WS-6-11 病態別にみた潰瘍性大腸炎に対する鏡視下手術の術式選択(ワークショップ6 炎症性腸疾患に対する外科治療の現状,第63回日本消化器外科学会総会) Reviewed

    前田 清, 井上 透, 野田 英児, 山下 好大, 山田 靖哉, 八代 正和, 六車 一哉, 大平 雅一, 西口 幸雄, 平川 弘聖

    一般社団法人日本消化器外科学会 日本消化器外科学会雑誌   41 ( 7 )   2008.07( ISSN:03869768

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  • RS-67 大腸癌における術後創感染の危険因子の検討(要望演題4-3 消化器外科とSSI対策3,第63回日本消化器外科学会総会) Reviewed

    野田 英児, 前田 清, 井上 透, 八代 正和, 山田 靖哉, 澤田 鉄二, 西口 幸雄, 大平 雅一, 石川 哲郎, 平川 弘聖

    一般社団法人日本消化器外科学会 日本消化器外科学会雑誌   41 ( 7 )   2008.07( ISSN:03869768

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  • RS-329 膵頭十二指腸切除術における消化管器械再建の手技と工夫(要望演題21-3 自動縫合器の使用法 肝・胆・膵,第63回日本消化器外科学会総会) Reviewed

    天野 良亮, 山田 靖哉, 西居 孝文, 土井 洋輔, 八代 正和, 澤田 鉄二, 仲田 文造, 大平 雅一, 石川 哲郎, 平川 弘聖

    一般社団法人日本消化器外科学会 日本消化器外科学会雑誌   41 ( 7 )   2008.07( ISSN:03869768

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  • O-1-226 低酸素耐性胃癌細胞株の樹立と転移能(基礎研究1,一般演題(口演),第63回日本消化器外科学会総会) Reviewed

    野田 諭, 八代 正和, 田中 浩明, 六車 一哉, 山田 靖哉, 澤田 鉄二, 仲田 文造, 大平 雅一, 石川 哲郎, 平川 弘聖

    日本消化器外科学会雑誌   41 ( 7 )   1181   2008.07( ISSN:03869768

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  • O-1-98 膵癌細胞におけるMUC5ACムチンの機能解析(胆・膵 研究3,一般演題(口演),第63回日本消化器外科学会総会) Reviewed

    山添 定明, 田中 浩明, 澤田 鉄二, 山田 靖哉, 八代 正和, 前田 清, 仲田 文造, 大平 雅一, 石川 哲郎, 平川 弘聖

    日本消化器外科学会雑誌   41 ( 7 )   1165   2008.07( ISSN:03869768

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  • O-1-228 癌幹細胞様SP細胞は抗癌剤耐性と腹膜転移に関与する(基礎研究1,一般演題(口演),第63回日本消化器外科学会総会) Reviewed

    西居 孝文, 八代 正和, 田中 浩明, 井上 透, 山田 靖哉, 山下 好人, 前田 清, 澤田 鉄二, 大平 雅一, 平川 弘聖

    日本消化器外科学会雑誌   41 ( 7 )   1181   2008.07( ISSN:03869768

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  • O-2-145 切除再建症例の臨床病理学的所見からみたT1a(MM)以深の胸部食道表在癌に対する治療戦略(食道 早期,一般演題(口演),第63回日本消化器外科学会総会) Reviewed

    大平 雅一, 久保 尚士, 田中 浩明, 山下 好人, 六車 一哉, 山田 靖哉, 八代 正和, 前田 清, 澤田 鉄二, 平川 弘聖

    日本消化器外科学会雑誌   41 ( 7 )   1227   2008.07( ISSN:03869768

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  • WS-6-11 病態別にみた潰瘍性大腸炎に対する鏡視下手術の術式選択(ワークショップ6 炎症性腸疾患に対する外科治療の現状,第63回日本消化器外科学会総会) Reviewed

    前田 清, 井上 透, 野田 英児, 山下 好大, 山田 靖哉, 八代 正和, 六車 一哉, 大平 雅一, 西口 幸雄, 平川 弘聖

    日本消化器外科学会雑誌   41 ( 7 )   1076   2008.07( ISSN:03869768

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  • RS-67 大腸癌における術後創感染の危険因子の検討(要望演題4-3 消化器外科とSSI対策3,第63回日本消化器外科学会総会) Reviewed

    野田 英児, 前田 清, 井上 透, 八代 正和, 山田 靖哉, 澤田 鉄二, 西口 幸雄, 大平 雅一, 石川 哲郎, 平川 弘聖

    日本消化器外科学会雑誌   41 ( 7 )   1105   2008.07( ISSN:03869768

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    CiNii Article

  • RS-329 膵頭十二指腸切除術における消化管器械再建の手技と工夫(要望演題21-3 自動縫合器の使用法 肝・胆・膵,第63回日本消化器外科学会総会) Reviewed

    天野 良亮, 山田 靖哉, 西居 孝文, 土井 洋輔, 八代 正和, 澤田 鉄二, 仲田 文造, 大平 雅一, 石川 哲郎, 平川 弘聖

    日本消化器外科学会雑誌   41 ( 7 )   1138   2008.07( ISSN:03869768

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  • RS-106 自動縫合器を用いた腹腔補助下幽門側胃切除術(LADG)後の消化管再建法について(要望演題5-2 自動縫合器を用いた胃切除後再建法の功罪2,第63回日本消化器外科学会総会) Reviewed

    六車 一哉, 澤田 鉄二, 豊川 貴弘, 久保 尚士, 田中 浩明, 八代 正和, 山田 靖哉, 山下 好人, 大平 雅一, 平川 弘聖

    日本消化器外科学会雑誌   41 ( 7 )   1110   2008.07( ISSN:03869768

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  • P-2-491 潰瘍性大腸炎におけるVitamin D Receptor発現と大腸癌との関連性(炎症性腸疾患2,一般演題(ポスター),第63回日本消化器外科学会総会) Reviewed

    田中 浩明, 前田 清, 和田 光二, 久保 尚士, 六車 一哉, 八代 正和, 山田 靖哉, 澤田 鉄二, 大平 雅一, 平川 弘聖

    日本消化器外科学会雑誌   41 ( 7 )   1488   2008.07( ISSN:03869768

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  • P-2-16 診断に難渋した多発性膵腫瘍の1例(胆・膵 症例3,一般演題(ポスター),第63回日本消化器外科学会総会) Reviewed

    土井 洋輔, 天野 良亮, 西居 孝文, 山田 靖哉, 八代 正和, 澤田 鉄二, 仲田 文造, 大平 雅一, 石川 哲郎, 平川 弘聖

    日本消化器外科学会雑誌   41 ( 7 )   1428   2008.07( ISSN:03869768

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  • P-1-467 胃癌の浸潤・転移に対するTGF-β, TGF-β受容体阻害剤の作用について(胃 研究,一般演題(ポスター),第63回日本消化器外科学会総会) Reviewed

    神藤 理, 八代 正和, 川尻 成美, 清水 清, 清水 寿通, 宮園 浩平, 平川 弘聖

    日本消化器外科学会雑誌   41 ( 7 )   1395   2008.07( ISSN:03869768

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  • O-2-87 分子標的治療薬mTOR阻害剤は5-FUの抗腫瘍効果を増強する(胃 研究2,一般演題(口演),第63回日本消化器外科学会総会) Reviewed

    松崎 太郎, 八代 正和, 田中 浩明, 井上 透, 山田 靖哉, 前田 清, 澤田 鉄二, 大平 雅一, 石川 哲郎, 平川 弘聖

    日本消化器外科学会雑誌   41 ( 7 )   1219   2008.07( ISSN:03869768

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  • O-2-348 膵頭十二指腸切除術における膵空腸吻合の手技の工夫と成績(胆・膵 PD再建5,一般演題(口演),第63回日本消化器外科学会総会) Reviewed

    山田 靖哉, 天野 良亮, 西居 孝文, 土井 洋輔, 八代 正和, 澤田 鉄二, 仲田 文造, 大平 雅一, 石川 哲郎, 平川 弘聖

    日本消化器外科学会雑誌   41 ( 7 )   1252   2008.07( ISSN:03869768

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  • O-2-319 原発性十二指腸癌切除例の検討(十二指腸,一般演題(口演),第63回日本消化器外科学会総会) Reviewed

    藤本 珠実, 天野 良亮, 山田 靖哉, 土井 洋輔, 西居 孝文, 八代 正和, 澤田 鉄二, 大平 雅一, 石川 哲郎, 平川 弘聖

    日本消化器外科学会雑誌   41 ( 7 )   1248   2008.07( ISSN:03869768

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  • O-2-271 大腸低分化腺癌・粘液癌の検討(大腸 悪性3,一般演題(口演),第63回日本消化器外科学会総会) Reviewed

    檀 信浩, 前田 清, 井上 透, 野田 英児, 八代 正和, 山田 靖哉, 西口 幸雄, 大平 雅一, 石川 哲郎, 平川 弘聖

    日本消化器外科学会雑誌   41 ( 7 )   1242   2008.07( ISSN:03869768

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  • O-2-23 術前化学療法が奏効した胃癌症例の検討(胃 化学療法4,一般演題(口演),第63回日本消化器外科学会総会) Reviewed

    貝崎 亮二, 六車 一哉, 豊川 貴弘, 久保 尚士, 八代 正和, 山下 好人, 澤田 鉄二, 大平 雅一, 石川 哲郎, 平川 弘聖

    日本消化器外科学会雑誌   41 ( 7 )   1211   2008.07( ISSN:03869768

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  • O-2-185 高齢者(50歳以上)潰瘍性大腸炎の手術成績の検討(炎症性腸疾患1,一般演題(口演),第63回日本消化器外科学会総会) Reviewed

    井上 透, 前田 清, 野田 英児, 八代 正和, 埜村 真也, 山田 靖哉, 澤田 鉄二, 大平 雅一, 西口 幸雄, 平川 弘聖

    日本消化器外科学会雑誌   41 ( 7 )   1232   2008.07( ISSN:03869768

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  • Laparoscopic resection of periadrenal paraganglioma - A report of 2 cases Reviewed

    Noda Eiji, Ishikawa Tetsuro, Maeda Kiyoshi, Inoue Toru, Amano Ryosuke, Kubo Naoshi, Tanaka Hiroaki, Muguruma Kazuya, Yamashita Yoshito, Yashiro Masakazu, Yamada Nobuya, Onoda Naoyoshi, Sawada Tetsuji, Nishiguchi Yukio, Ohira Masaichi, Hirakawa Kosei

    SURGICAL LAPAROSCOPY ENDOSCOPY & PERCUTANEOUS TECHNIQUES   18 ( 3 )   310 - 314   2008.06( ISSN:1530-4515

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  • Laparoscopic resection of periadrenal paraganglioma: a report of 2 cases. Reviewed

    Noda E, Ishikawa T, Maeda K, Inoue T, Amano R, Kubo N, Tanaka H, Muguruma K, Yamashita Y, Yashiro M, Yamada N, Onoda N, Sawada T, Nishiguchi Y, Ohira M, Hirakawa K

    Surgical laparoscopy, endoscopy & percutaneous techniques   18 ( 3 )   310 - 4   2008.06( ISSN:1530-4515

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    DOI: 10.1097/SLE.0b013e3181661907

    PubMed

  • Laparoscopic resection of periadrenal paraganglioma - A report of 2 cases Reviewed

    Eiji Noda, Tetsuro Ishikawa, Kiyoshi Maeda, Toru Inoue, Ryosuke Amano, Naoshi Kubo, Hiroaki Tanaka, Kazuya Muguruma, Yoshito Yamashita, Masakazu Yashiro, Nobuya Yamada, Naoyoshi Onoda, Tetsuji Sawada, Yukio Nishiguchi, Masaichi Ohira, Kosei Hirakawa

    SURGICAL LAPAROSCOPY ENDOSCOPY & PERCUTANEOUS TECHNIQUES   18 ( 3 )   310 - 4   2008.06( ISSN:1530-4515

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    Two cases with periadrenal paraganglioma are herein reported. Patient 1: A 26-year-old woman who presented with headache and hyperhidrosis was noted to have hypertension. Abdominal ultrasonography, computed tomography, magnetic resonance imaging, and I-131-tagged metaiodobenzylguanidine nuclear scintigraphy revealed a mass measuring 30 x 30 mm in size between the upper pole of the left kidney and the aorta. The value of urinary noradrenaline and normetanephrine were high. Patient 2: A 38-year-old woman who presented with headache and hyperhidrosis was noted to have hypertension. A preoperative imaging study revealed a mass measuring 20 x 20 mm in size between the upper pole of the left kidney and the aorta. The value of blood noradrenaline and urinary normetanephrine were high. In both cases, the paragangliomas were successfully removed laparoscopically without either any intraoperative or postoperative complications. Patient 1 is alive and doing well with no recurrence for 9 years, whereas patient 2 has been doing well for 3 years.

    DOI: 10.1097/SLE.0b013e3181661907

    PubMed

  • A novel transforming growth factor beta receptor kinase inhibitor, A-77, prevents the peritoneal dissemination of scirrhous gastric carcinoma Reviewed

    Kawajiri Hidemi, Yashiro Masakazu, Shinto Osamu, Nakamura Kazunori, Tendo Masashige, Takemura Satoru, Node Manabu, Hamashima Yoshio, Kajimoto Tetsuya, Sawada Tetsuji, Ohira Masaichi, Hirakawa Kosei

    CLINICAL CANCER RESEARCH   14 ( 9 )   2850 - 2860   2008.05( ISSN:1078-0432

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    DOI: 10.1158/1078-0432.CCR-07-1634

    PubMed

  • A novel transforming growth factor beta receptor kinase inhibitor, A-77, prevents the peritoneal dissemination of scirrhous gastric carcinoma Reviewed

    Hidemi Kawajiri, Masakazu Yashiro, Osamu Shinto, Kazunori Nakamura, Masashige Tendo, Satoru Takemura, Manabu Node, Yoshio Hamashima, Tetsuya Kajimoto, Tetsuji Sawada, Masaichi Ohira, Kosei Hirakawa

    CLINICAL CANCER RESEARCH   14 ( 9 )   2850 - 60   2008.05( ISSN:1078-0432

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    Purpose: Transforming growth factor receptor (TGF beta-R) is reported to correlate with the malignant potential of scirrhous gastric carcinoma. The aim of the current study is to clarify the possibility of molecular target therapy with a TGF beta-R inhibitor, A-77, for the treatment of peritoneal dissemination of scirrhous gastric cancer.
    Experimental Design: Three scirrhous gastric cancer cell lines and two fibroblasts were used. For in vivo experiments, the A-77 was administered i.p. to mouse models of peritoneal dissemination. The influences of A-77 on the adhesion ability, invasion ability, and the expression of adhesion molecules were examined in vitro.
    Results: The A-77 administration resulted in a significantly (P &lt; 0.01) better prognosis for the mice with peritoneal dissemination (median survival time, 51 days), compared with the control (median survival time, 25 days). A-77 therefore significantly (P &lt; 0.01) decreased the weight and number of metastatic nodes. The adhesive ability and invasion ability of cancer cells were significantly decreased by A-77. A-77 decreased the expression of alpha 2, alpha 3, and alpha 5 integrins in gastric cancer cells. The histologic findings showed the degree of fibrosis to be less in the tumors treated by A-77. A-77 decreased the growth of fibroblast and invasion-stimulating activity of fibroblasts on cancer cells.
    Conclusion: The TGF beta-R inhibitor, A-77, decreased the expression of integrins in cancer cells and the proliferation of fibroblasts, which resulted in the decreased adhesive and invasive abilities of scirrhous gastric cancer cells to peritoneum. A-77 is thus considered to be useful for the inhibition of peritoneal dissemination of scirrhous gastric carcinoma.

    DOI: 10.1158/1078-0432.CCR-07-1634

    PubMed

  • DP-007-5 当科における腹腔鏡補助下幽門側胃切除術(LADG)後再建法の工夫(第108回日本外科学会定期学術集会) Reviewed

    六車 一哉, 澤田 鉄二, 豊川 貴弘, 貝崎 亮二, 久保 尚士, 山田 靖哉, 八代 正和, 前田 清, 大平 雅一, 石川 哲郎, 平川 弘聖

    一般社団法人日本外科学会 日本外科学会雑誌   109 ( 2 )   2008.04( ISSN:03014894

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  • PD-5-9 スキルス胃癌の病態に基づいた分子標的治療薬の検討(第108回日本外科学会定期学術集会) Reviewed

    八代 正和, 川尻 成美, 神籐 理, 中村 和憲, 豊川 貴弘, 山下 好人, 山田 靖哉, 小野田 尚佳, 前田 清, 澤田 鉄二, 大平 雅一, 宮園 浩平, 野出 学, 梶本 哲也, 平川 弘聖

    一般社団法人日本外科学会 日本外科学会雑誌   109 ( 2 )   2008.04( ISSN:03014894

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  • PD-5-3 癌リンパ管新生からみた,スキルス胃癌のリンパ行性転移および腹膜播種の病態についての基礎的研究(第108回日本外科学会定期学術集会) Reviewed

    岩田 要, 八代 正和, 平川 弘聖, 宮園 浩平, 上西 紀夫

    一般社団法人日本外科学会 日本外科学会雑誌   109 ( 2 )   2008.04( ISSN:03014894

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  • DP-151-2 切除不能大腸癌肝転移症例に対するmFOLFOX6療法の有用性(第108回日本外科学会定期学術集会) Reviewed

    前田 清, 野田 英児, 天野 亮介, 山田 靖哉, 井上 透, 八代 正和, 六車 一哉, 久保 尚士, 西口 幸雄, 平川 弘聖

    一般社団法人日本外科学会 日本外科学会雑誌   109 ( 2 )   2008.04( ISSN:03014894

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  • DP-064-5 後腹膜神経鞘腫の6例の検討(第108回日本外科学会定期学術集会) Reviewed

    大北 仁裕, 天野 良亮, 山田 靖哉, 土井 洋輔, 西居 孝文, 山下 好人, 八代 正和, 澤田 鉄二, 大平 雅一, 石川 哲郎, 平川 弘聖

    一般社団法人日本外科学会 日本外科学会雑誌   109 ( 2 )   2008.04( ISSN:03014894

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  • DP-027-3 大腸疾患手術における機械的腸管前処置の有無による感染性術後合併症の比較検討(第108回日本外科学会定期学術集会) Reviewed

    野田 英児, 前田 清, 井上 透, 八代 正和, 山田 靖哉, 山下 好人, 澤田 鉄二, 西口 幸雄, 大平 雅一, 石川 哲郎, 平川 弘聖

    一般社団法人日本外科学会 日本外科学会雑誌   109 ( 2 )   2008.04( ISSN:03014894

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  • WS-4-6 TGF-β receptorを分子標的とした胃癌リンパ節転移抑制(第108回日本外科学会定期学術集会) Reviewed

    神藤 理, 八代 正和, 川尻 成美, 澤田 鉄二, 大平 雅一, 石川 哲郎, 清水 清, 清水 寿通, 宮園 浩平, 平川 弘聖

    一般社団法人日本外科学会 日本外科学会雑誌   109 ( 2 )   2008.04( ISSN:03014894

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  • SF-054-5 胃癌細胞株における5-FUとmTOR阻害剤の併用効果の検討(第108回日本外科学会定期学術集会) Reviewed

    松崎 太郎, 八代 正和, 貝崎 亮二, 久保 尚士, 田中 浩明, 六車 一哉, 井上 透, 山田 靖哉, 前田 清, 澤田 鉄二, 大平 雅一, 石川 哲郎, 西口 幸雄, 平川 弘聖

    一般社団法人日本外科学会 日本外科学会雑誌   109 ( 2 )   2008.04( ISSN:03014894

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  • SF-049-1 分子標的治療薬TGFbetaレセプター阻害剤の癌免疫療法への応用(第108回日本外科学会定期学術集会) Reviewed

    田中 浩明, 八代 正和, 神藤 理, 野田 英児, 天野 良亮, 久保 尚士, 六車 一哉, 井上 透, 山田 靖哉, 前田 清, 小野田 尚佳, 仲田 文造, 澤田 鉄二, 大平 雅一, 石川 哲郎, 平川 弘聖

    一般社団法人日本外科学会 日本外科学会雑誌   109 ( 2 )   2008.04( ISSN:03014894

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  • SF-028-2 胃癌腹膜転移への癌幹細胞様SP細胞の関与(第108回日本外科学会定期学術集会) Reviewed

    西居 孝文, 八代 正和, 神藤 理, 貝崎 亮二, 田中 浩明, 井上 透, 山田 靖哉, 山下 好人, 前田 清, 澤田 鉄二, 西口 幸雄, 加藤 保之, 大平 雅一, 石川 哲郎, 平川 弘聖

    一般社団法人日本外科学会 日本外科学会雑誌   109 ( 2 )   2008.04( ISSN:03014894

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  • DP-007-5 当科における腹腔鏡補助下幽門側胃切除術(LADG)後再建法の工夫(第108回日本外科学会定期学術集会) Reviewed

    六車 一哉, 澤田 鉄二, 豊川 貴弘, 貝崎 亮二, 久保 尚士, 山田 靖哉, 八代 正和, 前田 清, 大平 雅一, 石川 哲郎, 平川 弘聖

    日本外科学会雑誌   109 ( 2 )   359   2008.04( ISSN:03014894

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  • DP-151-2 切除不能大腸癌肝転移症例に対するmFOLFOX6療法の有用性(第108回日本外科学会定期学術集会) Reviewed

    前田 清, 野田 英児, 天野 亮介, 山田 靖哉, 井上 透, 八代 正和, 六車 一哉, 久保 尚士, 西口 幸雄, 平川 弘聖

    日本外科学会雑誌   109 ( 2 )   646   2008.04( ISSN:03014894

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  • DP-064-5 後腹膜神経鞘腫の6例の検討(第108回日本外科学会定期学術集会) Reviewed

    大北 仁裕, 天野 良亮, 山田 靖哉, 土井 洋輔, 西居 孝文, 山下 好人, 八代 正和, 澤田 鉄二, 大平 雅一, 石川 哲郎, 平川 弘聖

    日本外科学会雑誌   109 ( 2 )   472   2008.04( ISSN:03014894

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  • DP-027-3 大腸疾患手術における機械的腸管前処置の有無による感染性術後合併症の比較検討(第108回日本外科学会定期学術集会) Reviewed

    野田 英児, 前田 清, 井上 透, 八代 正和, 山田 靖哉, 山下 好人, 澤田 鉄二, 西口 幸雄, 大平 雅一, 石川 哲郎, 平川 弘聖

    日本外科学会雑誌   109 ( 2 )   398   2008.04( ISSN:03014894

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  • PD-5-3 癌リンパ管新生からみた,スキルス胃癌のリンパ行性転移および腹膜播種の病態についての基礎的研究(第108回日本外科学会定期学術集会) Reviewed

    岩田 要, 八代 正和, 平川 弘聖, 宮園 浩平, 上西 紀夫

    日本外科学会雑誌   109 ( 2 )   127   2008.04( ISSN:03014894

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  • WS-4-6 TGF-β receptorを分子標的とした胃癌リンパ節転移抑制(第108回日本外科学会定期学術集会) Reviewed

    神藤 理, 八代 正和, 川尻 成美, 澤田 鉄二, 大平 雅一, 石川 哲郎, 清水 清, 清水 寿通, 宮園 浩平, 平川 弘聖

    日本外科学会雑誌   109 ( 2 )   147   2008.04( ISSN:03014894

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  • SF-054-5 胃癌細胞株における5-FUとmTOR阻害剤の併用効果の検討(第108回日本外科学会定期学術集会) Reviewed

    松崎 太郎, 八代 正和, 貝崎 亮二, 久保 尚士, 田中 浩明, 六車 一哉, 井上 透, 山田 靖哉, 前田 清, 澤田 鉄二, 大平 雅一, 石川 哲郎, 西口 幸雄, 平川 弘聖

    日本外科学会雑誌   109 ( 2 )   254   2008.04( ISSN:03014894

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  • SF-049-1 分子標的治療薬TGFbetaレセプター阻害剤の癌免疫療法への応用(第108回日本外科学会定期学術集会) Reviewed

    田中 浩明, 八代 正和, 神藤 理, 野田 英児, 天野 良亮, 久保 尚士, 六車 一哉, 井上 透, 山田 靖哉, 前田 清, 小野田 尚佳, 仲田 文造, 澤田 鉄二, 大平 雅一, 石川 哲郎, 平川 弘聖

    日本外科学会雑誌   109 ( 2 )   247   2008.04( ISSN:03014894

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  • SF-028-2 胃癌腹膜転移への癌幹細胞様SP細胞の関与(第108回日本外科学会定期学術集会) Reviewed

    西居 孝文, 八代 正和, 神藤 理, 貝崎 亮二, 田中 浩明, 井上 透, 山田 靖哉, 山下 好人, 前田 清, 澤田 鉄二, 西口 幸雄, 加藤 保之, 大平 雅一, 石川 哲郎, 平川 弘聖

    日本外科学会雑誌   109 ( 2 )   221   2008.04( ISSN:03014894

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  • PD-5-9 スキルス胃癌の病態に基づいた分子標的治療薬の検討(第108回日本外科学会定期学術集会) Reviewed

    八代 正和, 川尻 成美, 神籐 理, 中村 和憲, 豊川 貴弘, 山下 好人, 山田 靖哉, 小野田 尚佳, 前田 清, 澤田 鉄二, 大平 雅一, 宮園 浩平, 野出 学, 梶本 哲也, 平川 弘聖

    日本外科学会雑誌   109 ( 2 )   129   2008.04( ISSN:03014894

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  • 今月の主題 linitis plastica型胃癌-病態と診断・治療の最前線 主題研究 スキルス(linitis plastica型)胃癌における癌細胞の特性,治療に向けた将来展望 Reviewed

    平川 弘聖, 八代 正和

    胃と腸   43 ( 5 )   833 - 844   2008.04( ISSN:05362180 ( eISSN:18821219

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    DOI: 10.11477/mf.1403101371

  • FGFR2-amplified gastric cancer cell lines require FGFR2 and Erbb3 signaling for growth and survival Reviewed

    Kunii Kaiko, Davis Lenora, Gorenstein Julie, Hatch Harold, Yashiro Masakazu, Di Bacco Alessandra, Elbi Cem, Lutterbach Bart

    CANCER RESEARCH   68 ( 7 )   2340 - 2348   2008.04( ISSN:0008-5472

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    DOI: 10.1158/0008-5472.CAN-07-5229

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  • FGFR2-amplified gastric cancer cell lines require FGFR2 and Erbb3 signaling for growth and survival Reviewed

    Kaiko Kunii, Lenora Davis, Julie Gorenstein, Harold Hatch, Masakazu Yashiro, Alessandra Di Bacco, Cem Elbi, Bart Lutterbach

    CANCER RESEARCH   68 ( 7 )   2340 - 2348   2008.04( ISSN:0008-5472

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    have identified a critical role for amplified FGFR2 in gastric cancer cell proliferation and survival. In a panel of gastric cancer cell lines, fibroblast growth factor receptor 2 (FGFR2) was overexpressed and tyrosine phosphorylated selectively in FGFR2-amplified cell lines KatoIII, Snu16, and OCUM-2M. FGFR2 kinase inhibition by a specific small-molecule inhibitor resulted in selective and potent growth inhibition in FGFR2-amplified cell lines, resulting in growth arrest in KatoIII cells and prominent induction of apoptosis in both Snu16 and OCUM-2M cells. FGFR2-amplified cell lines also contained elevated phosphotyrosine in EGFR, Her2, and Erbb3, but the elevated phosphorylation in EGFR could not be inhibited by gefitinib or erlotinib. We show that the elevated EGFR, Her2, and Erbb3 phosphotyrosine is dependent on FGFR2, revealing EGFR family kinases to be downstream targets of amplified FGFR2. Moreover, shRNA to Erbb3 resulted in a loss of proliferation, confirming a functional role for the activated EGFR signaling pathway. These results reveal that both the FGFR2 and EGFR family signaling pathways are activated in FGFR2-amplified gastric cancer cell lines to drive cell proliferation and survival. Inhibitors of FGFR2 or Erbb3 signaling may have therapeutic efficacy in the subset of gastric cancers containing FGFR2 amplification.

    DOI: 10.1158/0008-5472.CAN-07-5229

    PubMed

  • Reply: Identification of isolated tumour cells by detection of CEA and CK mRNA in peritoneal lavage fluid of gastric cancer patients Reviewed

    Katsuragi K., Yashiro M., Hirakawa K.

    BRITISH JOURNAL OF CANCER   98 ( 2 )   514 - 514   2008.01( ISSN:0007-0920

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    DOI: 10.1038/sj.bjc.6604190

  • FGFR2-amplified gastric cancer cell lines require FGFR2 and Erbb3 signaling for growth and survival.

    Cancer Res   68   2340   2008

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  • A novel transforming growth factor beta receptor kinase inhibitor, A-77, prevents the peritoneal dissemination of scirrhous gastric carcinoma

    Clin Cancer Res   14   2850   2008

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  • Efficacy of S-1 for Gastric Cancer Patients with Positive Peritoneal Lavage Cytology Reviewed

    Ako Eiji, Ohira Masaichi, Yamashita Yoshito, Kubo Naoshi, Muguruma Kazuya, Yashiro Masakazu, Sawada Tetsuji, Nakata Bunzo, Kato Yasuyuki, Hirakawa Kosei

    HEPATO-GASTROENTEROLOGY   55 ( 86-87 )   1939 - 1942   2008( ISSN:0172-6390

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  • Inhibitory effect of Ras signal transduction inhibitor on the growth of gastric cancer cells with ERas positive Reviewed

    Matsuzaki Taro, Ohira Masaichi, Ishikawa Tetsuro, Hirakawa Kosei, Yashiro Masakazu, Yasuda Kouichi, Kaizaki Ryouji, Muguruma Kazuya, Inoue Toru, Yamada Nobuya, Maeda Kiyoshi, Sawada Tetsuji

    Japanese Society for Molecular Tumor Marker Research, Japan Journal of Molecular Tumor Marker Research   23 ( 0 )   59 - 59   2008

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    DOI: 10.11241/jsmtmr.23.59

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  • Cancer stem cell-like SP cells are closely associated with the peritoneal dissemination in scirrhous gastric carcinoma. Reviewed

    Nishii Takafumi, Sawada Tetsuji, Nishiguchi Yukio, Kato Yasuyuki, Ohira Masaichi, Ishikawa Tetsuro, Hirakawa Kousei, Yashiro Masakazu, Shinto Osamu, Kaizaki Ryoji, Tanaka Hiroaki, Inoue Toru, Yamada Nobuya, Yamashita Yoshito, Maeda Kiyoshi

    Japanese Society for Molecular Tumor Marker Research, Japan Journal of Molecular Tumor Marker Research   23 ( 0 )   58 - 58   2008

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    DOI: 10.11241/jsmtmr.23.58

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  • Molecular Therapeutics for Esophageal Cancer -Especially as a Target for the EGFR Family- Reviewed

    Ohira M., Yashiro M., Maeda K., Sawada T., Hirakawa K., Yamashita Y., Yamazaki M., Ako E., Kubo N., Tanaka H., Muguruma K., Inoue T., Yamada N.

    The Japan Broncho-esophagological Society, Nihon Kikan Shokudoka Gakkai Kaiho   59 ( 2 )   187 - 188   2008( ISSN:0029-0645

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    DOI: 10.2468/jbes.59.187

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  • Inhibitory effect of Ras signal transduction inhibitor on the growth of gastric cancer cells with ERas positive Reviewed

    Matsuzaki Taro, Yashiro Masakazu, Yasuda Kouichi, Kaizaki Ryouji, Muguruma Kazuya, Inoue Toru, Yamada Nobuya, Maeda Kiyoshi, Sawada Tetsuji, Ohira Masaichi, Ishikawa Tetsuro, Hirakawa Kosei

    Japan Journal of Molecular Tumor Marker Research   23 ( 0 )   59 - 59   2008( eISSN:24338575

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    DOI: 10.11241/jsmtmr.23.59

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  • TGFβ受容体阻害剤を用いた胃癌分子標的治療 Reviewed

    八代 正和

    日本臨床 66(5)   475 - 479   2008

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  • Cancer stem cell-like SP cells are closely associated with the peritoneal dissemination in scirrhous gastric carcinoma. Reviewed

    Nishii Takafumi, Yashiro Masakazu, Shinto Osamu, Kaizaki Ryoji, Tanaka Hiroaki, Inoue Toru, Yamada Nobuya, Yamashita Yoshito, Maeda Kiyoshi, Sawada Tetsuji, Nishiguchi Yukio, Kato Yasuyuki, Ohira Masaichi, Ishikawa Tetsuro, Hirakawa Kousei

    Japan Journal of Molecular Tumor Marker Research   23 ( 0 )   58 - 58   2008( eISSN:24338575

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    DOI: 10.11241/jsmtmr.23.58

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  • スキルス胃癌の進展機序と線維芽細胞の増殖 Reviewed

    八代 正和

    日本臨床 66(5)   119 - 126   2008

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  • スキルス胃癌 Reviewed

    八代 正和

    消化器外科 31(5)   866 - 872   2008

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  • Molecular Therapeutics for Esophageal Cancer -Especially as a Target for the EGFR Family-

    Ohira M., Yamashita Y., Yamazaki M., Ako E., Kubo N., Tanaka H., Muguruma K., Inoue T., Yamada N., Yashiro M., Maeda K., Sawada T., Hirakawa K.

    Nihon Kikan Shokudoka Gakkai Kaiho   59 ( 2 )   187 - 188   2008( ISSN:00290645 ( eISSN:18806848

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    DOI: 10.2468/jbes.59.187

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  • Inhibition of cyclooxygenase-2 suppresses lymph node metastasis via reduction of lymphangiogenesis Reviewed

    Iwata Caname, Kano Mitsunobu R., Komuro Akiyoshi, Oka Masako, Kiyono Kunihiko, Johansson Erik, Morishita Yasuyuki, Yashiro Masakazu, Hirakawa Kosei, Kaminishi Michio, Miyazono Kohei

    CANCER RESEARCH   67 ( 21 )   10181 - 10189   2007.11( ISSN:0008-5472

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    DOI: 10.1158/0008-5472.CAN-07-2366

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  • A novel angiogenesis inhibitor, Ki23057, is useful for preventing the progression of colon cancer and the spreading of cancer cells to the liver Reviewed

    Sakurai Katsunobu, Yamada Nobuya, Yashiro Masakazu, Matsuzaki Taro, Komatsu Midori, Ohira Masaichi, Miwa Atsushi, Hirakawa Kosei

    EUROPEAN JOURNAL OF CANCER   43 ( 17 )   2612 - 2620   2007.11( ISSN:0959-8049

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    DOI: 10.1016/j.ejca.2007.09.002

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  • ERas oncogene expression and epigenetic regulation by histone acetylation in human cancer cells. Reviewed

    Yasuda K, Yashiro M, Sawada T, Ohira M, Hirakawa K

    Anticancer research   27 ( 6B )   4071 - 5   2007.11( ISSN:0250-7005

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  • ERas oncogene expression and epigenetic regulation by histone acetylation in human cancer cells Reviewed

    Koichi Yasuda, Masakazu Yashiro, Tetsuji Sawada, Masaichi Ohira, Kosei Hirakawa

    ANTICANCER RESEARCH   27 ( 6B )   4071 - 4075   2007.11( ISSN:0250-7005

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    The ERas oncogene is a recently identified gene that supports the tumorigenic growth of embryonic stem (ES) cells by producing a constitutively active Ras protein. However the expression of ERas in cancer cells remains unclear. In this study, ERas mRNA expression was examined in 20 human cancer cell lines and 5 normal cell lines. ERas mRNA was found in 4 out of 7 colorectal carcinomas, 2 out of 6 pancreatic carcinomas, I out of 3 breast carcinomas, none in the esophageal carcinomas and none in the normal cells. Histone deacetylase inhibitor treatment resulted in ERas expression in I out of 3 colorectal carcinomas, 2 out of 2 breast carcinomas and 3 out of 3 normal cell lines. These findings suggested that the ERas oncogene might be associated with the development of human carcinomas. Up-regulation of ERas by histone acetylation might be one of the mechanisms reversing/overcoming the epigenetic transcriptional silencing of the ERas oncogenes.

    PubMed

  • Inhibition of cyclooxygenase-2 suppresses lymph node metastasis via reduction of lymphangiogenesis Reviewed

    Caname Iwata, Mitsunobu R. Kano, Akiyoshi Komuro, Masako Oka, Kunihiko Kiyono, Erik Johansson, Yasuyuki Morishita, Masakazu Yashiro, Kosei Hirakawa, Michio Kaminishi, Kohei Miyazono

    CANCER RESEARCH   67 ( 21 )   10181 - 10189   2007.11( ISSN:0008-5472

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    Cyclooxygenase-2 (COX-2) inhibitor has been reported to suppress tumor progression. However, it is unclear whether this inhibitor can also prevent lymphatic metastasis. To determine the effects of COX-2 inhibitor on lymphatic metastasis, etodolac, a COX-2 inhibitor, was given p.o. to mice bearing orthotopic xenografts or with carcinomatous peritonitis induced with a highly metastatic human diffuse-type gastric carcinoma cell line, OCUM-2MLN. Tumor lymphangiogenesis was significantly decreased in etodolac-treated mice compared with control mice. Consistent with this decrease in lymphangiogenesis, the total weight of metastatic lymph nodes was less in etodolac-treated mice than in control mice. Immunohistochemical analysis revealed that the major source of vascular endothelial growth factor-C (VEGF-C) and VEGF-D was F4/80-positive macrophages in our models. The mRNA levels of VEGF-C in mouse macrophage-like RAW264.7 cells, as well as those in tumor tissues, were suppressed by etodolac. The growth of human dermal lymphatic microvascular endothelial cells was also suppressed by etodolac. Supporting these findings, etodolac also inhibited lymphangiogenesis in a model of chronic aseptic peritonitis, suggesting that COX-2 can enhance lymphangiogenesis in the absence of cancer cells. Our findings suggest that COX-2 inhibitor may be useful for prophylaxis of lymph node metastasis by reducing macrophage-mediated tumor lymphangiogenesis.

    DOI: 10.1158/0008-5472.CAN-07-2366

    PubMed

  • ERas oncogene expression and epigenetic regulation by histone acetylation in human cancer cells. Reviewed

    Yasuda K, Yashiro M, Sawada T, Ohira M, Hirakawa K

    Anticancer research   27 ( 6B )   4071 - 5   2007.11( ISSN:0250-7005

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    PubMed

  • A novel angiogenesis inhibitor, Ki23057, is useful for preventing the progression of colon cancer and the spreading of cancer cells to the liver Reviewed

    Katsunobu Sakurai, Nobuya Yamada, Masakazu Yashiro, Taro Matsuzaki, Midori Komatsu, Masaichi Ohira, Atsushi Miwa, Kosei Hirakawa

    EUROPEAN JOURNAL OF CANCER   43 ( 17 )   2612 - 20   2007.11( ISSN:0959-8049

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    Ki23057 is a new, small synthetic tyrosine kinase inhibitor that blocks autophosphorylation of the VEGF receptor2 (VEGFR2). To determine the effect of Ki23057 as an anti-angiogenic agent, we studied the effect of Ki23057 for colon cancer and vascular endothelial cells in vitro and in vivo. Ki23057 inhibited VEGF-induced proliferation of human umbilical vein endothelial cells (HUVECs), whereas no inhibitory effect of Ki23057 on the proliferation of three colon cancer cells (LM-H3, LoVo and LS174T) was observed by means of the cell count assay Ki23057 inhibited tube formation of HUVECs. Immunoprecipitation demonstrated that Ki23057 inhibited tyrosine phosphorylation of VEGFR2 in HUVECs. Ki23057 exhibited a significant inhibitory effect on the growth of the xenografted LM-H3 tumours and the spreading of cancer cells to the liver. Anti-CD31 antibody stained significantly fewer microvessels in the xenografted tumours treated with Ki23057 compared with controls. Ki23057 may be a promising new antiangiogenic agent for colon cancer. (c) 2007 Elsevier Ltd. All rights reserved.

    DOI: 10.1016/j.ejca.2007.09.002

    PubMed

  • Suppression of tumor lymphangiogenesis and lymph node metastasis by conventional cyclooxygenase-2 (COX-2) inhibitor, Etodolac Reviewed

    Iwata Caname, Kano Mitsunobu R., Yashiro Masakazu, Hirakawa Kosei, Miyazono Kohei, Kaminishi Michio

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   22   A229 - A229   2007.10( ISSN:0815-9319

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  • Quality of Life in Patients with Unresectable Malignant Colorectal Obstruction Treated by Stent Placement Reviewed

    MAEDA Kiyoshi, INOUE Toru, NODA Eiji, NISHIHARA Tamahiro, YASHIRO Masakazu, FUKUNAGA Sinya, HIRAKAWA Kosei

    27 ( 6 )   839 - 843   2007.09( ISSN:13402242

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    CiNii Article

  • Quality of Life in Patients with Unresectable Malignant Colorectal Obstruction Treated by Stent Placement Reviewed

    MAEDA Kiyoshi, INOUE Toru, NODA Eiji, NISHIHARA Tamahiro, YASHIRO Masakazu, FUKUNAGA Sinya, HIRAKAWA Kosei

    27 ( 6 )   839 - 843   2007.09( ISSN:13402242

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  • Prognostic impact of PCR-based identification of isolated tumour cells in the peritoneal lavage fluid of gastric cancer patients who underwent a curative R0 resection. Reviewed

    Katsuragi K, Yashiro M, Sawada T, Osaka H, Ohira M, Hirakawa K

    British journal of cancer   97 ( 4 )   550 - 6   2007.08( ISSN:0007-0920

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    DOI: 10.1038/sj.bjc.6603909

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  • Prognostic impact of PCR-based identification of isolated tumour cells in the peritoneal lavage fluid of gastric cancer patients who underwent a curative R0 resection Reviewed

    Katsuragi K., Yashiro M., Sawada T., Osaka H., Ohira M., Hirakawa K.

    BRITISH JOURNAL OF CANCER   97 ( 4 )   550 - 556   2007.08( ISSN:0007-0920

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    DOI: 10.1038/sj.bjc.6603909

  • A synergistic antitumor effect of interleukin-2 addition with CD80 immunogene therapy for peritoneal metastasis of gastric carcinoma Reviewed

    Kosaka Kinshi, Yashiro Masakazu, Sakate Yoji, Hirakawa Kosei

    DIGESTIVE DISEASES AND SCIENCES   52 ( 8 )   1946 - 1953   2007.08( ISSN:0163-2116

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    DOI: 10.1007/s10620-006-9637-8

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  • A synergistic antitumor effect of interleukin-2 addition with CD80 immunogene therapy for peritoneal metastasis of gastric carcinoma Reviewed

    Kinshi Kosaka, Masakazu Yashiro, Yoji Sakate, Kosei Hirakawa

    DIGESTIVE DISEASES AND SCIENCES   52 ( 8 )   1946 - 53   2007.08( ISSN:0163-2116

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    The co-stimulatory molecule CD80 is a ligand of CD28, which plays a key role in the induction of cell-mediated immune responses. Many tumors, including gastric cancer, decrease the expression of CD80, which results in the failure of immune recognition. We evaluated the effect of interleukin-2 addition combined with CD80 infection on the peritoneal metastasis in gastric cancer. CD80 infection combined with interleukin-2 addition significantly increased the activated cytotoxicity of mononuclear cells compared to CD80 gene infection and compared to the lacZ control group. In vivo, the survival of animals with intraperitoneal tumor was longest in those given CD80 infection with interleukin-2 addition (median survival, 46 days), followed by those given interleukin-2 (39 days), those given CD80 infection (37 days), and those given lacZ (29 days). These results suggest that interleukin-2 addition might contribute to improving the observed outcome of CD80 immunogene therapy in peritoneal metastasis of gastric carcinoma.

    DOI: 10.1007/s10620-006-9637-8

    PubMed

  • O-1-240 大腸癌肝転移症例における予後規定因子の解析と治療戦略(大腸癌 転移1,一般演題(口演),第62回日本消化器外科学会定期学術総会) Reviewed

    山田 靖哉, 天野 良亮, 八代 正和, 前田 清, 澤田 鉄二, 西口 幸雄, 大平 雅一, 石川 哲朗, 西野 裕二, 平川 弘聖

    一般社団法人日本消化器外科学会 日本消化器外科学会雑誌   40 ( 7 )   2007.07( ISSN:03869768

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  • SY-1-1-6 FGF-R2/K-samIIおよびTGF-βreceptorを分子標的としたスキルス胃癌転移の治療(シンポジウム1-1 消化器癌の発生機序から見た治療戦略-消化管癌,第62回日本消化器外科学会定期学術総会) Reviewed

    八代 正和, 川尻 成美, 神籐 理, 中村 和憲, 豊川 貴弘, 宮園 浩平, 野出 学, 梶本 哲也, 三輪 篤史, 平川 弘聖

    一般社団法人日本消化器外科学会 日本消化器外科学会雑誌   40 ( 7 )   2007.07( ISSN:03869768

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    CiNii Article

  • P-2-511 腫瘍径5cm以下の進行結腸癌に対する腹腔鏡補助下手術の中期成績(大腸・肛門 鏡視下手術2,一般演題(ポスター),第62回日本消化器外科学会定期学術総会) Reviewed

    前田 清, 野田 英児, 井上 透, 福永 真也, 和田 光二, 八代 正和, 山田 靖哉, 西口 幸雄, 大平 雅一, 平川 弘聖

    一般社団法人日本消化器外科学会 日本消化器外科学会雑誌   40 ( 7 )   2007.07( ISSN:03869768

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  • P-2-497 大腸mp癌の臨床病理学的特徴と治療方針の検討(大腸・肛門 危険因子・予後2,一般演題(ポスター),第62回日本消化器外科学会定期学術総会) Reviewed

    井上 透, 前田 清, 野田 英児, 福永 真也, 八代 正和, 山田 靖哉, 澤田 鉄二, 西口 幸雄, 大平 雅一, 平川 弘聖

    一般社団法人日本消化器外科学会 日本消化器外科学会雑誌   40 ( 7 )   2007.07( ISSN:03869768

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  • P-2-136 Adjuvant chemotherapyとしてのTS-1を用いたCY1胃癌の治療戦略(胃癌 CY1-2,一般演題(ポスター),第62回日本消化器外科学会定期学術総会) Reviewed

    六車 一哉, 澤田 鉄二, 田中 浩明, 井上 透, 山下 好人, 山田 靖哉, 八代 正和, 前田 清, 大平 雅一, 平川 弘聖

    一般社団法人日本消化器外科学会 日本消化器外科学会雑誌   40 ( 7 )   2007.07( ISSN:03869768

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    CiNii Article

  • P-1-249 スキルス胃癌腹膜播種におけるTGFβ-R阻害剤と抗癌剤の併用効果(胃癌 進行2,一般演題(ポスター),第62回日本消化器外科学会定期学術総会) Reviewed

    川尻 成美, 八代 正和, 井上 透, 西口 幸雄, 石川 哲郎, 加藤 保之, 宮園 浩平, 野出 学, 梶本 哲也, 平川 弘聖

    一般社団法人日本消化器外科学会 日本消化器外科学会雑誌   40 ( 7 )   2007.07( ISSN:03869768

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  • P-1-190 胃癌切除症例におけるKGFおよびK-sam発現の免疫組織学的検討(胃 病理,一般演題(ポスター),第62回日本消化器外科学会定期学術総会) Reviewed

    豊川 貴弘, 八代 正和, 井上 透, 山田 靖哉, 小野田 尚佳, 澤田 鉄二, 仲田 文造, 大平 雅一, 石川 哲郎, 平川 弘聖

    一般社団法人日本消化器外科学会 日本消化器外科学会雑誌   40 ( 7 )   2007.07( ISSN:03869768

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  • O-3-114 抗癌剤の腫瘍内投与による抗腫瘍免疫の誘導効果(免疫,一般演題(口演),第62回日本消化器外科学会定期学術総会) Reviewed

    田中 浩明, 八代 正和, 六車 一哉, 井上 透, 山田 靖哉, 山下 好人, 前田 清, 澤田 鉄二, 大平 雅一, 平川 弘聖

    一般社団法人日本消化器外科学会 日本消化器外科学会雑誌   40 ( 7 )   2007.07( ISSN:03869768

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  • O-2-54 胆道癌におけるKGFR/Ksam-IIをターゲットにした分子標的治療の可能性の検討(胆 研究,一般演題(口演),第62回日本消化器外科学会定期学術総会) Reviewed

    天野 良亮, 山田 靖哉, 八代 正和, 澤田 鉄二, 西口 幸雄, 大平 雅一, 石川 哲郎, 西野 裕二, 三輪 篤史, 平川 弘聖

    一般社団法人日本消化器外科学会 日本消化器外科学会雑誌   40 ( 7 )   2007.07( ISSN:03869768

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  • O-2-34 スキルス胃癌リンパ節転移に対するTGF-β阻害剤を用いた分子標的治療(胃癌 分子生物学2,一般演題(口演),第62回日本消化器外科学会定期学術総会) Reviewed

    神藤 理, 八代 正和, 川尻 成美, 石川 哲郎, 加藤 保之, 西口 幸雄, 清水 清, 清水 寿通, 宮園 浩平, 平川 弘聖

    一般社団法人日本消化器外科学会 日本消化器外科学会雑誌   40 ( 7 )   2007.07( ISSN:03869768

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  • O-2-33 胃癌細胞におけるERasシグナル伝達阻害剤の増殖抑制効果の検討(胃癌 分子生物学2,一般演題(口演),第62回日本消化器外科学会定期学術総会) Reviewed

    松崎 太郎, 八代 正和, 安田 晃一, 貝崎 亮二, 山田 靖哉, 山下 好人, 前田 清, 小野田 尚佳, 西口 幸雄, 平川 弘聖

    一般社団法人日本消化器外科学会 日本消化器外科学会雑誌   40 ( 7 )   2007.07( ISSN:03869768

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  • O-2-32 胃癌におけるERas遺伝子発現(胃癌 分子生物学2,一般演題(口演),第62回日本消化器外科学会定期学術総会) Reviewed

    貝崎 亮二, 八代 正和, 神藤 理, 田中 浩明, 井上 透, 澤田 鉄二, 仲田 文造, 西口 幸雄, 大平 雅一, 平川 弘聖

    一般社団法人日本消化器外科学会 日本消化器外科学会雑誌   40 ( 7 )   2007.07( ISSN:03869768

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  • O-2-111 腹腔鏡下大腸切除術における腹直筋鞘ブロックの有用性(大腸癌 腹腔鏡3,一般演題(口演),第62回日本消化器外科学会定期学術総会) Reviewed

    野田 英児, 前田 清, 井上 透, 山田 靖哉, 八代 正和, 山下 好人, 澤田 鉄二, 西口 幸雄, 大平 雅一, 平川 弘聖

    一般社団法人日本消化器外科学会 日本消化器外科学会雑誌   40 ( 7 )   2007.07( ISSN:03869768

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  • VW-2-7 遊離空腸移植とその術後管理における工夫(ビデオワークショップ2 消化器外科手術における血行再建の工夫と合併症対策,第62回日本消化器外科学会定期学術総会) Reviewed

    山下 好人, 大平 雅一, 久保 尚士, 六車 一哉, 井上 透, 山田 靖哉, 八代 正和, 西口 幸雄, 石川 哲郎, 平川 弘聖

    一般社団法人日本消化器外科学会 日本消化器外科学会雑誌   40 ( 7 )   2007.07( ISSN:03869768

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  • RS-36 切除再建症例の病理組織学的所見からみた食道m3,sm1癌に対する治療戦略(要望演題8 食道表在癌,第62回日本消化器外科学会定期学術総会) Reviewed

    大平 雅一, 中川 泰生, 山下 好人, 久保 尚士, 六車 一哉, 山田 靖哉, 八代 正和, 澤田 鉄二, 西口 幸雄, 平川 弘聖

    一般社団法人日本消化器外科学会 日本消化器外科学会雑誌   40 ( 7 )   2007.07( ISSN:03869768

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  • O-1-240 大腸癌肝転移症例における予後規定因子の解析と治療戦略(大腸癌 転移1,一般演題(口演),第62回日本消化器外科学会定期学術総会) Reviewed

    山田 靖哉, 天野 良亮, 八代 正和, 前田 清, 澤田 鉄二, 西口 幸雄, 大平 雅一, 石川 哲朗, 西野 裕二, 平川 弘聖

    日本消化器外科学会雑誌   40 ( 7 )   1148   2007.07( ISSN:03869768

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  • O-2-111 腹腔鏡下大腸切除術における腹直筋鞘ブロックの有用性(大腸癌 腹腔鏡3,一般演題(口演),第62回日本消化器外科学会定期学術総会) Reviewed

    野田 英児, 前田 清, 井上 透, 山田 靖哉, 八代 正和, 山下 好人, 澤田 鉄二, 西口 幸雄, 大平 雅一, 平川 弘聖

    日本消化器外科学会雑誌   40 ( 7 )   1166   2007.07( ISSN:03869768

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  • O-2-32 胃癌におけるERas遺伝子発現(胃癌 分子生物学2,一般演題(口演),第62回日本消化器外科学会定期学術総会) Reviewed

    貝崎 亮二, 八代 正和, 神藤 理, 田中 浩明, 井上 透, 澤田 鉄二, 仲田 文造, 西口 幸雄, 大平 雅一, 平川 弘聖

    日本消化器外科学会雑誌   40 ( 7 )   1156   2007.07( ISSN:03869768

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  • VW-2-7 遊離空腸移植とその術後管理における工夫(ビデオワークショップ2 消化器外科手術における血行再建の工夫と合併症対策,第62回日本消化器外科学会定期学術総会) Reviewed

    山下 好人, 大平 雅一, 久保 尚士, 六車 一哉, 井上 透, 山田 靖哉, 八代 正和, 西口 幸雄, 石川 哲郎, 平川 弘聖

    日本消化器外科学会雑誌   40 ( 7 )   1080   2007.07( ISSN:03869768

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  • SY-1-1-6 FGF-R2/K-samIIおよびTGF-βreceptorを分子標的としたスキルス胃癌転移の治療(シンポジウム1-1 消化器癌の発生機序から見た治療戦略-消化管癌,第62回日本消化器外科学会定期学術総会) Reviewed

    八代 正和, 川尻 成美, 神籐 理, 中村 和憲, 豊川 貴弘, 宮園 浩平, 野出 学, 梶本 哲也, 三輪 篤史, 平川 弘聖

    日本消化器外科学会雑誌   40 ( 7 )   1002   2007.07( ISSN:03869768

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  • RS-36 切除再建症例の病理組織学的所見からみた食道m3,sm1癌に対する治療戦略(要望演題8 食道表在癌,第62回日本消化器外科学会定期学術総会) Reviewed

    大平 雅一, 中川 泰生, 山下 好人, 久保 尚士, 六車 一哉, 山田 靖哉, 八代 正和, 澤田 鉄二, 西口 幸雄, 平川 弘聖

    日本消化器外科学会雑誌   40 ( 7 )   1103   2007.07( ISSN:03869768

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  • P-2-511 腫瘍径5cm以下の進行結腸癌に対する腹腔鏡補助下手術の中期成績(大腸・肛門 鏡視下手術2,一般演題(ポスター),第62回日本消化器外科学会定期学術総会) Reviewed

    前田 清, 野田 英児, 井上 透, 福永 真也, 和田 光二, 八代 正和, 山田 靖哉, 西口 幸雄, 大平 雅一, 平川 弘聖

    日本消化器外科学会雑誌   40 ( 7 )   1402   2007.07( ISSN:03869768

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  • P-2-497 大腸mp癌の臨床病理学的特徴と治療方針の検討(大腸・肛門 危険因子・予後2,一般演題(ポスター),第62回日本消化器外科学会定期学術総会) Reviewed

    井上 透, 前田 清, 野田 英児, 福永 真也, 八代 正和, 山田 靖哉, 澤田 鉄二, 西口 幸雄, 大平 雅一, 平川 弘聖

    日本消化器外科学会雑誌   40 ( 7 )   1401   2007.07( ISSN:03869768

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  • P-2-136 Adjuvant chemotherapyとしてのTS-1を用いたCY1胃癌の治療戦略(胃癌 CY1-2,一般演題(ポスター),第62回日本消化器外科学会定期学術総会) Reviewed

    六車 一哉, 澤田 鉄二, 田中 浩明, 井上 透, 山下 好人, 山田 靖哉, 八代 正和, 前田 清, 大平 雅一, 平川 弘聖

    日本消化器外科学会雑誌   40 ( 7 )   1355   2007.07( ISSN:03869768

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  • P-1-249 スキルス胃癌腹膜播種におけるTGFβ-R阻害剤と抗癌剤の併用効果(胃癌 進行2,一般演題(ポスター),第62回日本消化器外科学会定期学術総会) Reviewed

    川尻 成美, 八代 正和, 井上 透, 西口 幸雄, 石川 哲郎, 加藤 保之, 宮園 浩平, 野出 学, 梶本 哲也, 平川 弘聖

    日本消化器外科学会雑誌   40 ( 7 )   1272   2007.07( ISSN:03869768

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  • P-1-190 胃癌切除症例におけるKGFおよびK-sam発現の免疫組織学的検討(胃 病理,一般演題(ポスター),第62回日本消化器外科学会定期学術総会) Reviewed

    豊川 貴弘, 八代 正和, 井上 透, 山田 靖哉, 小野田 尚佳, 澤田 鉄二, 仲田 文造, 大平 雅一, 石川 哲郎, 平川 弘聖

    日本消化器外科学会雑誌   40 ( 7 )   1264   2007.07( ISSN:03869768

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  • O-3-114 抗癌剤の腫瘍内投与による抗腫瘍免疫の誘導効果(免疫,一般演題(口演),第62回日本消化器外科学会定期学術総会) Reviewed

    田中 浩明, 八代 正和, 六車 一哉, 井上 透, 山田 靖哉, 山下 好人, 前田 清, 澤田 鉄二, 大平 雅一, 平川 弘聖

    日本消化器外科学会雑誌   40 ( 7 )   1203   2007.07( ISSN:03869768

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  • O-2-54 胆道癌におけるKGFR/Ksam-IIをターゲットにした分子標的治療の可能性の検討(胆 研究,一般演題(口演),第62回日本消化器外科学会定期学術総会) Reviewed

    天野 良亮, 山田 靖哉, 八代 正和, 澤田 鉄二, 西口 幸雄, 大平 雅一, 石川 哲郎, 西野 裕二, 三輪 篤史, 平川 弘聖

    日本消化器外科学会雑誌   40 ( 7 )   1159   2007.07( ISSN:03869768

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  • O-2-34 スキルス胃癌リンパ節転移に対するTGF-β阻害剤を用いた分子標的治療(胃癌 分子生物学2,一般演題(口演),第62回日本消化器外科学会定期学術総会) Reviewed

    神藤 理, 八代 正和, 川尻 成美, 石川 哲郎, 加藤 保之, 西口 幸雄, 清水 清, 清水 寿通, 宮園 浩平, 平川 弘聖

    日本消化器外科学会雑誌   40 ( 7 )   1157   2007.07( ISSN:03869768

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  • O-2-33 胃癌細胞におけるERasシグナル伝達阻害剤の増殖抑制効果の検討(胃癌 分子生物学2,一般演題(口演),第62回日本消化器外科学会定期学術総会) Reviewed

    松崎 太郎, 八代 正和, 安田 晃一, 貝崎 亮二, 山田 靖哉, 山下 好人, 前田 清, 小野田 尚佳, 西口 幸雄, 平川 弘聖

    日本消化器外科学会雑誌   40 ( 7 )   1157   2007.07( ISSN:03869768

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  • A novel K-samII/FGF-R2 autophosphorylation inhibitor is therapeutically useful for scirrhous gastric carcinoma with K-samll amplification Reviewed

    Yashiro M., Nakamura K., Sawada T., Kawajiri H., Shimizu T., Miwa A., Hirakawa K.

    JOURNAL OF CLINICAL ONCOLOGY   25 ( 18 )   2007.06( ISSN:0732-183X

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  • Clinical significance of ERas oncogene on cancer Reviewed

    Yasuda K., Yashiro M., Sawada T., Ohira M., Hirakawa K.

    JOURNAL OF CLINICAL ONCOLOGY   25 ( 18 )   2007.06( ISSN:0732-183X

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  • A CASE OF MESENTERIC PHLEBOSCLEROSIS CLUED BY ACUTE APPENDICITIS Reviewed

    OTA Kouhei, YANAGAWA Kenichi, TAKAHATA Tetsuya, NODA Eiji, INOUE Toru, NISHIHARA Tamahiro, YASHIRO Masakazu, MAEDA Kiyoshi, HIRAKAWA Kosei

    Gastroenterol Endosc   49 ( 4 )   1130 - 1135   2007.04( ISSN:03871207

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  • Laparoscope assisted small laparotomy operation for ulcerative colitis : emergency operation conditions Reviewed

    12 ( 2 )   177 - 181   2007.04( ISSN:13446703 ( eISSN:21866643

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    DOI: 10.11477/mf.4426100036

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  • DP-042-4 食道表在癌におけるリンパ節転移とVEGF-Cの発現およびCXCR 4の発現との関連についての検討(第107回日本外科学会定期学術集会) Reviewed

    中川 泰生, 大平 雅一, 山下 好人, 野田 英児, 六車 一哉, 山田 靖哉, 八代 正和, 前田 清, 澤田 鉄二, 石川 哲郎, 西口 幸雄, 加藤 保之, 平川 弘聖

    一般社団法人日本外科学会 日本外科学会雑誌   108 ( 2 )   2007.03( ISSN:03014894

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  • DP-120-8 大腸癌生検組織でのchemokine receptor CXCR4の発現とリンパ行性転移の検討(第107回日本外科学会定期学術集会) Reviewed

    福永 真也, 前田 清, 野田 英児, 西原 承浩, 井上 透, 山田 靖哉, 八代 正和, 山下 好人, 澤田 鉄二, 西口 幸雄, 加藤 保之, 大平 雅一, 石川 哲郎, 平川 弘聖

    一般社団法人日本外科学会 日本外科学会雑誌   108 ( 2 )   2007.03( ISSN:03014894

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  • 樹状細胞成熟化作用を有する抗癌剤の同定と抗腫瘍免疫の誘導 Reviewed

    田中 浩明, 八代 正和, 山田 靖哉, 山下 好人, 六車 一哉, 澤田 鉄二, 前田 清, 石川 哲郎, 平川 弘聖, MIZUMOTO Norikatsu, TAKASHIMA Akira

    一般社団法人日本外科学会 日本外科学会雑誌   108   2007.03( ISSN:03014894

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  • 胃癌腹膜播種におけるTGFβ-R阻害剤の有用性 Reviewed

    川尻 成美, 八代 正和, 竹村 哲, 中村 和憲, 天道 正成, 井上 透, 山田 靖哉, 山下 好人, 前田 清, 小野田 尚佳, 澤田 鉄二, 仲田 文造, 西口 幸雄, 大平 雅一, 石川 哲郎, 加藤 保之, 宮園 浩平, 野出 学, 梶本 哲也, 平川 弘聖

    一般社団法人日本外科学会 日本外科学会雑誌   108   2007.03( ISSN:03014894

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  • 胃癌組織におけるERasの発現 Reviewed

    貝崎 亮二, 八代 正和, 神藤 理, 田中 浩明, 六車 一哉, 井上 透, 山下 好人, 山田 靖哉, 小野田 尚佳, 前田 清, 澤田 鉄二, 仲田 文造, 西口 幸雄, 大平 雅一, 石川 哲郎, 加藤 保之, 平川 弘聖

    一般社団法人日本外科学会 日本外科学会雑誌   108   2007.03( ISSN:03014894

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  • 胃GIST診断における超音波内視鏡下FNAの有用性およびGISTに対する治療戦略 Reviewed

    六車 一哉, 澤田 鉄二, 豊川 貴弘, 井上 透, 山下 好人, 八代 正和, 山田 靖哉, 前田 清, 大平 雅一, 平川 弘聖

    一般社団法人日本外科学会 日本外科学会雑誌   108   2007.03( ISSN:03014894

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  • DP-042-4 食道表在癌におけるリンパ節転移とVEGF-Cの発現およびCXCR 4の発現との関連についての検討(第107回日本外科学会定期学術集会) Reviewed

    中川 泰生, 大平 雅一, 山下 好人, 野田 英児, 六車 一哉, 山田 靖哉, 八代 正和, 前田 清, 澤田 鉄二, 石川 哲郎, 西口 幸雄, 加藤 保之, 平川 弘聖

    日本外科学会雑誌   108 ( 2 )   412   2007.03( ISSN:03014894

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  • DP-120-8 大腸癌生検組織でのchemokine receptor CXCR4の発現とリンパ行性転移の検討(第107回日本外科学会定期学術集会) Reviewed

    福永 真也, 前田 清, 野田 英児, 西原 承浩, 井上 透, 山田 靖哉, 八代 正和, 山下 好人, 澤田 鉄二, 西口 幸雄, 加藤 保之, 大平 雅一, 石川 哲郎, 平川 弘聖

    日本外科学会雑誌   108 ( 2 )   561   2007.03( ISSN:03014894

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  • 樹状細胞成熟化作用を有する抗癌剤の同定と抗腫瘍免疫の誘導 Reviewed

    田中 浩明, 八代 正和, 山田 靖哉, 山下 好人, 六車 一哉, 澤田 鉄二, 前田 清, 石川 哲郎, 平川 弘聖

    日本外科学会雑誌   108   257   2007.03( ISSN:03014894

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  • 胃癌腹膜播種におけるTGFβ-R阻害剤の有用性 Reviewed

    川尻 成美, 八代 正和, 竹村 哲, 中村 和憲, 天道 正成, 井上 透, 山田 靖哉, 山下 好人, 前田 清, 小野田 尚佳, 澤田 鉄二, 仲田 文造, 西口 幸雄, 大平 雅一, 石川 哲郎, 加藤 保之, 宮園 浩平, 野出 学, 梶本 哲也, 平川 弘聖

    日本外科学会雑誌   108   153   2007.03( ISSN:03014894

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  • 胃癌組織におけるERasの発現 Reviewed

    貝崎 亮二, 八代 正和, 神藤 理, 田中 浩明, 六車 一哉, 井上 透, 山下 好人, 山田 靖哉, 小野田 尚佳, 前田 清, 澤田 鉄二, 仲田 文造, 西口 幸雄, 大平 雅一, 石川 哲郎, 加藤 保之, 平川 弘聖

    日本外科学会雑誌   108   261   2007.03( ISSN:03014894

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  • 胃GIST診断における超音波内視鏡下FNAの有用性およびGISTに対する治療戦略 Reviewed

    六車 一哉, 澤田 鉄二, 豊川 貴弘, 井上 透, 山下 好人, 八代 正和, 山田 靖哉, 前田 清, 大平 雅一, 平川 弘聖

    日本外科学会雑誌   108   151   2007.03( ISSN:03014894

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  • Improvement of cancer-targeting therapy, using nanocarriers for intractable solid tumors by inhibition of TGF-beta signaling Reviewed

    Kano Mitsunobu R., Bae Younsoo, Iwata Caname, Morishita Yasuyuki, Yashiro Masakazu, Oka Masako, Fujii Tomoko, Komuro Akiyoshi, Kiyono Kunihiko, Kaminishi Michio, Hirakawa Kosei, Ouchi Yasuyoshi, Nishiyama Nobuhiro, Kataoka Kazunori, Miyazono Kohei

    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA   104 ( 9 )   3460 - 3465   2007.02( ISSN:0027-8424

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    DOI: 10.1073/pnas.0611660104

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  • Selective cyclooxygenase-2 inhibitor downregulates the paracrine epithelial-mesenchymal interactions of growth in scirrhous gastric carcinoma Reviewed

    Yashiro Masakazu, Nakazawa Kazunori, Tendo Masashige, Kosaka Kinshi, Shinto Osamu, Hirakawa Kosei

    INTERNATIONAL JOURNAL OF CANCER   120 ( 3 )   686 - 693   2007.02( ISSN:0020-7136

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    DOI: 10.1002/ijc.22329

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  • Selective cyclooxygenase-2 inhibitor downregulates the paracrine epithelial-mesenchymal interactions of growth in scirrhous gastric carcinoma Reviewed

    Masakazu Yashiro, Kazunori Nakazawa, Masashige Tendo, Kinshi Kosaka, Osamu Shinto, Kosei Hirakawa

    INTERNATIONAL JOURNAL OF CANCER   120 ( 3 )   686 - 93   2007.02( ISSN:0020-7136

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    The importance of cancer-mesenchymal interactions in the aggressive behavior of scirrhous gastric cancer is supported by experimental and clinical evidences. We have previously reported that gastric fibroblasts secretion of keratinocyte growth factor (KGF) underline the remarkable proliferation of scirrhous gastric cancer cells. Cyciooxygenase-2 (COX-2) is not only expressed in cancer cells, but also in interstitial fibroblasts in gastric carcinoma. To clarify the mechanisms responsible for the antiproliferation effect of COX-2 inhibitors, effect of COX-2 inhibitor on the paracrine epithelial-mesenchymal interactions of growth was examined. Scirrhous gastric cancer cell line, OCUM-2M, gastric fibroblasts, NF-21, and COX-2 inhibitor, JTE-522, were used. Growth-interaction was examined by calculating the number of cancer cells or by measuring [3 H] thymidine incorporation of cancer cells. Effect of JTE-522 on KGF expression from NF-21 cells and OCUM-2M cells was analyzed by ELISA and RT-PCR. The conditioned medium from gastric fibroblasts significantly stimulated the growth of scirrhous gastric cancer cells. JTE-522 at the concentrations of 10(-5) and 10(-6) M significantly decreased the growth-stimulating activity of gastric fibro6lasts. JTE-522 reduced the expression of KGF mRNA and the production of KGF from gastric fibroblasts. Oral administration of ITE-522 significantly decreased the size of xenografted tumor coinoculated with OCUM-2M cells and NF-21 cells in nude mice. JTE-522 decreased COX-2 expression and Ki67 labeling index within the coinoculated tumor. These findings suggested that a selective COX-2 inhibitor, JTE-522, downregulates KGF production from gastric fibroblasts, resulting in the inhibition of paracrine epithelial-mesenchymal interactions of proliferation between scirrhous gastric cancer cells and gastric fibroblasts. (c) 2006 Wiley-Liss, Inc.

    DOI: 10.1002/ijc.22329

    PubMed

  • Improvement of cancer-targeting therapy, using nanocarriers for intractable solid tumors by inhibition of TGF-beta signaling Reviewed

    Mitsunobu R. Kano, Younsoo Bae, Caname Iwata, Yasuyuki Morishita, Masakazu Yashiro, Masako Oka, Tomoko Fujii, Akiyoshi Komuro, Kunihiko Kiyono, Michio Kaminishi, Kosei Hirakawa, Yasuyoshi Ouchi, Nobuhiro Nishiyama, Kazunori Kataoka, Kohei Miyazono

    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA   104 ( 9 )   3460 - 3465   2007.02( ISSN:0027-8424

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    Transforming growth factor (TGF)-beta plays a pivotal role in regulation of progression of cancer through effects on tumor microenvironment as well as on cancer cells. TGF-beta inhibitors have recently been shown to prevent the growth and metastasis of certain cancers. However, there may be adverse effects caused by TGF-beta signaling inhibition, including the induction of cancers by the repression of TGF-beta-mediated growth inhibition. Here, we present an application of a short-acting, small-molecule TGF-beta type I receptor (T beta R-1) inhibitor at a low dose in treating several experimental intractable solid tumors, including pancreatic adenocarcinoma and diffuse-type gastric cancer, characterized by hypovascularity and thick fibrosis in tumor microenvironments. Low-dose T beta R-1 inhibitor altered neither TGF-beta signaling in cancer cells nor the amount of fibrotic components. However, it decreased pericyte coverage of the endothelium without reducing endlothelial area specifically in tumor neovasculature and promoted accumulation of macromolecules, including anticancer nanocarriers, in the tumors. Compared with the absence of T beta R-1 inhibitor, anticancer nanocarriers exhibited potent growth-inhibitory effects on these cancers in the presence of T beta R-1 inhibitor. The use of TiSR-1 inhibitor combined with nanocarriers; may thus be of significant clinical and practical importance in treating intractable solid cancers.

    DOI: 10.1073/pnas.0611660104

    PubMed

  • Association between expression of chemokine receptor CXCR4 and lymph node metastasis in colorectal cancer Reviewed

    Fukunaga Shinya, Maeda Kiyoshi, Noda Eiji, Nishihara Tamahiro, Inoue Touru, Yamada Nobuya, Yamashita Yoshito, Yashiro Masakazu, Sawada Tetuji, Oohira Masaichi, Hirakawa Kousei

    CLINICAL & EXPERIMENTAL METASTASIS   24 ( 4 )   279 - 279   2007( ISSN:0262-0898

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  • Selective cyclooxygenase-2 inhibitor downregulates the paracrine epithelial-mesenchymal interactions of growth in scirrhous gastric carcinoma.

    Int J Cancer   120   686   2007

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  • Improvement of cancer-targeting therapy, using nanocarriers for intractable solid tumors by inhibition of TGF-beta signaling.

    Proc Natl Acad Sci USA   104   3460   2007

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  • Inhibition of cyclooxygenase-2 suppresses lymph node metastasis via reduction of lymphangiogenesis.

    Cancer Res   67   10181   2007

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  • Combination effect of transforming growth factor & beta-receptor inhibitor and S-1 on the lymph node metastasis for gastric cancer Reviewed

    Kawajiri Hidemi, Yashiro Masakazu, Masashige Tendo, Yamada Nobuya, Sawada Tetsuji, Hirakawa Kosei

    CLINICAL & EXPERIMENTAL METASTASIS   24 ( 4 )   305 - 305   2007( ISSN:0262-0898

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  • Quality of Life in Patients with Unresectable Malignant Colorectal Obstruction Treated by Stent Placement Reviewed

    Maeda Kiyoshi, Inoue Toru, Noda Eiji, Nishihara Tamahiro, Yashiro Masakazu, Fukunaga Sinya, Hirakawa Kosei

    Japanese Society for Abdominal Emergency Medicine, Nihon Fukubu Kyukyu Igakkai Zasshi (Journal of Abdominal Emergency Medicine)   27 ( 6 )   839 - 843   2007( ISSN:1340-2242

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    The treatment of colorectal obstruction caused by unresectable malignancies usually requires a stoma creation. However, these patients are debilitated from advanced malignancy and have limited life expectancy. Moreover, the quality of life is usually adversely affected by the presence of a stoma. In such patients, we attempted stent placement to avoid stoma creation. This treatment may be less invasive as compared with stoma creation, and provide an improvement in the quality of life of patients with unresectable malignant obstruction of the colon and rectum.

    DOI: 10.11231/jaem.27.839

    CiNii Article

  • K-sam expression is associated with tumor progression and prognosis in gastric cancer Reviewed

    Toyokawa Takahiro, Yashiro Masakazu, Muguruma Kazuya, Inoue Toru, Yamashita Yoshito, Sawada Tetsuji, Ohira Masaichi, Hirakawa Kosei

    CLINICAL & EXPERIMENTAL METASTASIS   24 ( 4 )   288 - 288   2007( ISSN:0262-0898

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  • Expression and regulation of ERas oncogene on cancer cell lines Reviewed

    Yasuda Kouichi, Sawada Tetsuji, Ohira Masaichi, Nakata Bunzo, Ishikawa Tetsuro, Nishino Hiroji, Hirakawa Kosei, Yashiro Masakazu, Muguruma Kazuya, Nishihara Tamahiro, Inoue Toru, Yamashita Yoshito, Yamada Nobuya, Onoda Naoyoshi, Maeda Kiyoshi

    Japanese Society for Molecular Tumor Marker Research, Japan Journal of Molecular Tumor Marker Research   22 ( 0 )   30 - 31   2007

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    DOI: 10.11241/jsmtmr.22.30

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  • Combination effect of TGF&beta;-R inhibitor and S-1 for lymph-node metastasis of gastric cancer Reviewed

    Kawajiri Hidemi, Yashiro Masakazu, Miyazono Kouhei, Hirakawa Kousei

    Japanese Society for Molecular Tumor Marker Research, Japan Journal of Molecular Tumor Marker Research   22 ( 0 )   59 - 59   2007

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    DOI: 10.11241/jsmtmr.22.59

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  • A CASE OF MESENTERIC PHLEBOSCLEROSIS CLUED BY ACUTE APPENDICITIS Reviewed

    OTA Kouhei, YANAGAWA Kenichi, TAKAHATA Tetsuya, NODA Eiji, INOUE Torn, NISHIHARA Tamahiro, YASHIRO Masakazu, MAEDA Kiyoshi, HIRAKAWA Kosei

    Japan Gastroenterological Endoscopy Society, GASTROENTEROLOGICAL ENDOSCOPY   49 ( 4 )   1130 - 1135   2007( ISSN:0387-1207

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    A 75-year-old woman was admitted to our hospital with a complaint of abdominal pain in the right lower quadrant. An emergent operation was performed under diagnosis of acute appendicitis. Pathological diagnosis was acute gangrenous appendicitis. Abdominal computed tomogram showed calcification in the wall and mesenterium of the right side of colon. She had colonoscopy examination, barium enema after the operation leading the diagnosis of mesenteric phlebosclerosis. We reported a rare case of mesenteric phlebosclerosis.

    DOI: 10.11280/gee1973b.49.1130

    CiNii Article

  • FGF-R2/K-samllを分子標的としたスキルス胃癌の新規治療法 Reviewed

    八代 正和, 平川 弘聖

    消化器科 44   447 - 454   2007

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  • Quality of Life in Patients with Unresectable Malignant Colorectal Obstruction Treated by Stent Placement Reviewed

    Maeda Kiyoshi, Inoue Toru, Noda Eiji, Nishihara Tamahiro, Yashiro Masakazu, Fukunaga Sinya, Hirakawa Kosei

    Nihon Fukubu Kyukyu Igakkai Zasshi (Journal of Abdominal Emergency Medicine)   27 ( 6 )   839 - 843   2007( ISSN:13402242 ( eISSN:18824781

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    The treatment of colorectal obstruction caused by unresectable malignancies usually requires a stoma creation. However, these patients are debilitated from advanced malignancy and have limited life expectancy. Moreover, the quality of life is usually adversely affected by the presence of a stoma. In such patients, we attempted stent placement to avoid stoma creation. This treatment may be less invasive as compared with stoma creation, and provide an improvement in the quality of life of patients with unresectable malignant obstruction of the colon and rectum.

    DOI: 10.11231/jaem.27.839

    CiNii Article

  • Expression and regulation of ERas oncogene on cancer cell lines Reviewed

    Yasuda Kouichi, Yashiro Masakazu, Muguruma Kazuya, Nishihara Tamahiro, Inoue Toru, Yamashita Yoshito, Yamada Nobuya, Onoda Naoyoshi, Maeda Kiyoshi, Sawada Tetsuji, Ohira Masaichi, Nakata Bunzo, Ishikawa Tetsuro, Nishino Hiroji, Hirakawa Kosei

    Japan Journal of Molecular Tumor Marker Research   22 ( 0 )   30 - 31   2007( eISSN:24338575

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    DOI: 10.11241/jsmtmr.22.30

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  • Combination effect of TGFβ-R inhibitor and S-1 for lymph-node metastasis of gastric cancer Reviewed

    Kawajiri Hidemi, Yashiro Masakazu, Miyazono Kouhei, Hirakawa Kousei

    Japan Journal of Molecular Tumor Marker Research   22 ( 0 )   59 - 59   2007( eISSN:24338575

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    DOI: 10.11241/jsmtmr.22.59

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  • A CASE OF MESENTERIC PHLEBOSCLEROSIS CLUED BY ACUTE APPENDICITIS Reviewed

    OTA Kouhei, YANAGAWA Kenichi, TAKAHATA Tetsuya, NODA Eiji, INOUE Torn, NISHIHARA Tamahiro, YASHIRO Masakazu, MAEDA Kiyoshi, HIRAKAWA Kosei

    GASTROENTEROLOGICAL ENDOSCOPY   49 ( 4 )   1130 - 1135   2007( ISSN:03871207 ( eISSN:18845738

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    A 75-year-old woman was admitted to our hospital with a complaint of abdominal pain in the right lower quadrant. An emergent operation was performed under diagnosis of acute appendicitis. Pathological diagnosis was acute gangrenous appendicitis. Abdominal computed tomogram showed calcification in the wall and mesenterium of the right side of colon. She had colonoscopy examination, barium enema after the operation leading the diagnosis of mesenteric phlebosclerosis. We reported a rare case of mesenteric phlebosclerosis.

    DOI: 10.11280/gee1973b.49.1130

    CiNii Article

  • A synergic inhibitory-effect of combination with selective cyclooxygenase-2 inhibitor and S-1 on the peritoneal metastasis for scirrhous gastric cancer cells Reviewed

    Tendo Masashige, Yashiro Masakazu, Nakazawa Kazunori, Yamada Nobuya, Sawada Tetsuji, Ohira Masaichi, Hirakawa Kosei

    CANCER LETTERS   244 ( 2 )   247 - 251   2006.12( ISSN:0304-3835

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    DOI: 10.1016/j.canlet.2005.12.019

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  • A synergic inhibitory-effect of combination with selective cyclooxygenase-2 inhibitor and S-1 on the peritoneal metastasis for scirrhous gastric cancer cells Reviewed

    Masashige Tendo, Masakazu Yashiro, Kazunori Nakazawa, Nobuya Yamada, Tetsuji Sawada, Masaichi Ohira, Kosei Hirakawa

    CANCER LETTERS   244 ( 2 )   247 - 51   2006.12( ISSN:0304-3835

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    An inhibitory-effect of a selective cyclooxygenase-2 (COX-2) inhibitor on peritoneal metastasis of scirrhous gastric carcinoma was investigated in vivo. Peritoneal metastasis had developed after intraperitoneal inoculation of scirrhous gastric cancer cells, OCUM-2MD3, in nude mice. COX-2 inhibitor and/or S-1 were administered orally in nude mice with peritoneal metastasis. Oral administration of COX-2 inhibitor and S-1 significantly prolonged survival rates of these nude mice, compared with either alone. These findings suggested that combining S-I and COX-2 inhibitor administration obtain a synergistic inhibitory-effect on the peritoneal metastasis of scirrhous gastric carcinoma. (c) 2006 Elsevier Ireland Ltd. All rights reserved.

    DOI: 10.1016/j.canlet.2005.12.019

    PubMed

  • S9-2. 胃全摘術後の全器械吻合によるRoux-en Yおよび空腸間置再建法(第35回胃外科・術後障害研究会) Reviewed

    六車 一哉, 澤田 鉄二, 山下 好人, 井上 透, 西原 承浩, 山田 靖哉, 八代 正和, 前田 清, 大平 雅一, 石川 哲郎, 平川 弘聖

    一般社団法人日本消化器外科学会 日本消化器外科学会雑誌   39 ( 11 )   1763 - 1764   2006.11( ISSN:03869768

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  • S9-2. 胃全摘術後の全器械吻合によるRoux-en Yおよび空腸間置再建法(第35回胃外科・術後障害研究会) Reviewed

    六車 一哉, 澤田 鉄二, 山下 好人, 井上 透, 西原 承浩, 山田 靖哉, 八代 正和, 前田 清, 大平 雅一, 石川 哲郎, 平川 弘聖

    日本消化器外科学会雑誌   39 ( 11 )   1763 - 1764   2006.11( ISSN:03869768

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  • [A case of advanced gastric cancer with malignant ascites responding to weekly paclitaxel therapy]. Reviewed

    Toyokawa T, Sawada T, Muguruma K, Kim T, Kimura K, Inoue T, Yamashita Y, Yashiro M, Ohira M, Hirakawa K

    Gan to kagaku ryoho. Cancer & chemotherapy   33 ( 11 )   1637 - 40   2006.11( ISSN:0385-0684

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  • A novel molecular targeting compound as K-samII/FGF-R2 phosphorylation inhibitor, Ki23057, for scirrhous gastric cancer Reviewed

    Nakamura Kazunori, Yashiro Masakazu, Matsuoka Tasuku, Tendo Masashige, Shimizu Toshiyuki, Miwa Atsushi, Hirakawa Kosei

    GASTROENTEROLOGY   131 ( 5 )   1530 - 1541   2006.11( ISSN:0016-5085

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    DOI: 10.1053/j.gastro.2006.08.030

    PubMed

  • [A case of advanced gastric cancer with malignant ascites responding to weekly paclitaxel therapy]. Reviewed

    Toyokawa T, Sawada T, Muguruma K, Kim T, Kimura K, Inoue T, Yamashita Y, Yashiro M, Ohira M, Hirakawa K

    Gan to kagaku ryoho. Cancer & chemotherapy   33 ( 11 )   1637 - 40   2006.11( ISSN:0385-0684

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    PubMed

  • [A case of advanced gastric cancer with malignant ascites responding to weekly paclitaxel therapy]. Reviewed

    Toyokawa T, Sawada T, Muguruma K, Kim T, Kimura K, Inoue T, Yamashita Y, Yashiro M, Ohira M, Hirakawa K

    Gan to kagaku ryoho. Cancer & chemotherapy   33 ( 11 )   1637 - 1640   2006.11( ISSN:0385-0684

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  • A novel molecular targeting compound as K-samII/FGF-R2 phosphorylation inhibitor, Ki23057, for scirrhous gastric cancer Reviewed

    Kazunori Nakamura, Masakazu Yashiro, Tasuku Matsuoka, Masashige Tendo, Toshiyuki Shimizu, Atsushi Miwa, Kosei Hirakawa

    GASTROENTEROLOGY   131 ( 5 )   1530 - 41   2006.11( ISSN:0016-5085

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    Background & Aims: Scirrhous gastric carcinoma carries the highest mortality of all gastric cancers. The poor prognosis is reported to be associated with K-samII amplification, which encodes fibroblast growth factor receptor type 2 (FGF-R-2). Ki23057, a newly developed small molecule-acting K-samII/FGF-R-2 autophosphorylation inhibitor, is a tyrosine kinase inhibitor that competes with adenosine triphosphate for the binding site. The aim of the current study is to clarify the possibility of molecular target therapy with Ki23057 for treating scirrhous gastric cancer. Methods: Five human gastric cancer cell lines were used. OCUM-2MD3 and OCUM-8 were derived from scirrhous carcinomas. MKN-7, MKN-4S, and MKN-74 cells were derived from nonscirrhous carcinomas. In vitro effects of Ki23057 on cell growth were determined by calculating the number of cancer cells. The influences of Ki23057 on the mitogen-activated protein kinase and phosphatidylinositol 3 kinase signaling pathways and the apoptosis pathway in the gastric cancer cells were also examined. For in vivo experiments, the Ki23057 was administered orally to mouse models of peritoneal dissemination. Results: K-samII amplification was found in OCUM-2MD3 and OCUM-8 cells but not in MKN-7, MKN-45, or MKN-74 cells. Ki23057 significantly inhibited the proliferation of scirrhous cancer cells but not nonscirrhous gastric carcinoma cells. Ki23057 decreased phosphorylation of K-samII/FGF-R2, extracellular signal-regulated kinase, and Akt and increased apoptosis in scirrhous cancer lines. The oral Ki23057 administration significantly (P &lt;.001) prolonged survival of mice with peritoneal dissemination following injection of OCUM-2MD3 scirrhous cancer cells. Conclusions: A novel K-samII/FGF-R2 phosphorylation inhibitor, Ki23057, appears therapeutically promising in scirrhous gastric carcinoma with K-samII amplification.

    DOI: 10.1053/j.gastro.2006.08.030

    PubMed

  • Stent placement for intestinal stenoses Reviewed

    61 ( 9 )   1159 - 1164   2006.09( ISSN:03869857 ( eISSN:18821278

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    DOI: 10.11477/mf.1407101123

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  • Synergic antiproliferative effect of DNA methyltransferase inhibitor in combination with anticancer drugs in gastric carcinoma Reviewed

    ZHANG Xiaotian, YASHIRO Masakazu, OHIRA Masaichi, REN Jun, HIRAKAWA Kosei

    Cancer science   97 ( 9 )   938 - 944   2006.09( ISSN:13479032

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  • Synergic antiproliferative effect of DNA methyltransferase inhibitor in combination with anticancer drugs in gastric carcinoma Reviewed

    ZHANG Xiaotian, YASHIRO Masakazu, OHIRA Masaichi, REN Jun, HIRAKAWA Kosei

    Cancer Sci   97 ( 9 )   938 - 944   2006.09( ISSN:13479032

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  • Decreased expression of the adhesion molecule desmoglein-2 is associated with diffuse-type gastric carcinoma Reviewed

    Yashiro Masakazu, Nishioka Nobuaki, Hirakawa Kosei

    EUROPEAN JOURNAL OF CANCER   42 ( 14 )   2397 - 2403   2006.09( ISSN:0959-8049

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    DOI: 10.1016/j.ejca.2006.03.024

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  • Synergic antiproliferative effect of DNA methyltransferase inhibitor in combination with anticancer drugs in gastric carcinoma Reviewed

    Zhang Xiaotian, Yashiro Masakazu, Ohira Masaichi, Ren Jun, Hirakawa Kosei

    CANCER SCIENCE   97 ( 9 )   938 - 944   2006.09( ISSN:1349-7006

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    DOI: 10.1111/j.1349-7006.2006.00253.x

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  • Histone deacetylase inhibitor, trichostatin A, increases the chemosensitivity of anticancer drugs in gastric cancer cell lines. Reviewed

    Zhang X, Yashiro M, Ren J, Hirakawa K

    Oncology reports   16 ( 3 )   563 - 8   2006.09( ISSN:1021-335X

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    PubMed

  • Histone deacetylase inhibitor, trichostatin A, increases the chemosensitivity of anticancer drugs in gastric cancer cell lines Reviewed

    Zhang Xiaotian, Yashiro Masakazu, Ren Jun, Hirakawa Kosei

    ONCOLOGY REPORTS   16 ( 3 )   563 - 568   2006.09( ISSN:1021-335X

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  • Histone deacetylase inhibitor, trichostatin A, increases the chemosensitivity of anticancer drugs in gastric cancer cell lines Reviewed

    Xiaotian Zhang, Masakazu Yashiro, Jun Ren, Kosei Hirakawa

    ONCOLOGY REPORTS   16 ( 3 )   563 - 568   2006.09( ISSN:1021-335X ( eISSN:1791-2431

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    Epigenetic alterations of the histone acetylation play an important role in the regulation of gene expression associated with cell cycles and apoptosis that may affect the chemosensitivity of gastric carcinomas. Recently, a histone deacetylase inhibitor, trichostatin A (TSA), was proven to be a chemo-sensitizer on human erythroleukemia cells. With the aim of improving the chemotherapeutic efficacy of gastric carcinoma, the effect of TSA on the chemosensitivity of several anticancer drugs in gastric carcinoma cells was investigated. Human gastric cancer cell lines, OCUM-8 and MKN-74, and 5 anticancer drugs, 5-fluorouracil (5-FU), paclitaxel (PTX), oxaliplatin (OXA), irinotecan (SN38) and gemcitabine (GEM) were used. In both gastric cancer cell lines, a synergistic anti-proliferative effect by the combination of TSA (30 ng/ml) with 5-FU, PTX or SN38 showed a synergistic anti-proliferative effect in OCUM-8 and MKN-74 cells. TSA increases the expression of p21, p53, DAPK-1 and the DAPK-2 gene in both OCUM-8 and MKN-74 cells. In conclusion, TSA is a promising chemotherapeutical agent in combination with anticancer drugs of 5-FU, PTX and SN38 in gastric cancer cell lines. The up-regulation of p53, p21, DAPK-1 and DAPK-2 might be associated with the synergistic effect of TSA.

    PubMed

  • Histone deacetylase inhibitor, trichostatin A, increases the chemosensitivity of anticancer drugs in gastric cancer cell lines. Reviewed

    Zhang X, Yashiro M, Ren J, Hirakawa K

    Oncology reports   16 ( 3 )   563 - 8   2006.09( ISSN:1021-335X

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    PubMed

  • Decreased expression of the adhesion molecule desmoglein-2 is associated with diffuse-type gastric carcinoma Reviewed

    Masakazu Yashiro, Nobuaki Nishioka, Kosei Hirakawa

    EUROPEAN JOURNAL OF CANCER   42 ( 14 )   2397 - 403   2006.09( ISSN:0959-8049

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    Desmoglein-2 (Dsg2) is one of the components of the cell-cell adherence junction. We previously reported that loss of heterozygosity at chromosome 18q12, on which the Dsg2 gene exists, is frequently found in diffuse-type gastric cancers. This study investigated the relationship between Dsg2 expression and diffuse-type gastric cancers. A total of 112 primary tumours resected from patients with gastric cancer were stained with a monoclonal antibody against Dsg2 and examined for correlations between the expression of Dsg2 and various clinicopathological factors, including loss of heterozygosity on chromosome 18q and prognosis. Dsg2 is immunolocalised at cell-cell boundaries in normal gastric mucosa. Loss of Dsg2 expression was observed in 33 of 112 gastric tumours. There was a statistically significant correlation between a decrease in Dsg2 staining and loss of tumour differentiation (P &lt; 0.001), tumour macroscopic feature (P &lt; 0.001) and peritoneal dissemination (P = 0.023), and Dsg2-negative staining was correlated significantly with loss of heterozygosity on chromosome 18q12 (P = 0.001). The prognosis of patients with Dsg2-negative tumours was significantly worse than that of those with Dsg2-positive tumours (log rank, P &lt; 0.01), while multivariate analysis revealed that Dsg2 was not an independent prognostic factor. These findings suggest that decreased expression of Dsg2 is associated with diffuse-type gastric cancers and poor prognosis in gastric carcinoma. (c) 2006 Elsevier Ltd. All rights reserved.

    DOI: 10.1016/j.ejca.2006.03.024

    PubMed

  • Synergic antiproliferative effect of DNA methyltransferase inhibitor in combination with anticancer drugs in gastric carcinoma Reviewed

    Xiaotian Zhang, Masakazu Yashiro, Masaichi Ohira, Jun Ren, Kosei Hirakawa

    CANCER SCIENCE   97 ( 9 )   938 - 944   2006.09( ISSN:1347-9032

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    Epigenetic alterations of DNA methylation play an important role in the regulation of gene expression associated with chemosensitivity of gastric carcinomas. With the aim of improving the chemotherapeutic efficacy of gastric carcinoma, the effect of DNA methyltransferase inhibitor, 5-aza-CdR, on the chemosensitivity of five anticancer drugs was investigated. Human gastric cancer cell lines, OCUM-2M and MKN-74, and five anticancer drugs, 5-FU, PTX, OXA, SN38, and GEM, were used. In both gastric cancer cell lines, a synergistic antiproliferative effect by a combination of 5-aza-CdR at 5 mu M was found in SN38 and GEM. 5-Aza-CdR at 5 mu M increased apoptosis induced by SN38 and GEM in both cell lines. 5-Aza-CdR increases the expression of DAPK-2 and DAPK-3, RASSF1, and THBS1 genes in both OCUM-2M and MKN-74 cells, but not that of hMLH1, p16, MGMT, E-cadherin, and p53 genes. These findings suggest that 5-aza-CdR is a promising chemotherapeutical agent for gastric carcinomas, in combination with the anticancer drugs SN38 and GEM, in apoptosis signaling. The upregulation of DAPK-2 and DAPK-3, RASSF1, and THBS1 genes by 5-aza-CdR might be associated with the synergistic effect.

    DOI: 10.1111/j.1349-7006.2006.00253.x

    PubMed

  • スキルス胃癌の組織形成と進展における胃癌細胞と間質細胞の相互作用因子の同定及び解析 Reviewed

    児玉 良典, 大沼 和弘, 仙波 秀峰, 伊藤 彰彦, 八代 正和, 平川 弘聖, 横崎 宏

    日本癌学会総会記事   65回   209 - 209   2006.09( ISSN:0546-0476

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  • 0087 食道表在癌におけるリンパ節転移とVEGF-Cの発現および簇出との関連についての検討(食道表在癌・Barrett腺癌,一般演題,第61回日本消化器外科学会定期学術総会) Reviewed

    中川 泰生, 大平 雅一, 山下 好人, 野田 英児, 山田 靖哉, 八代 正和, 前田 清, 澤田 鉄二, 小野田 尚佳, 平川 弘聖

    一般社団法人日本消化器外科学会 日本消化器外科学会雑誌   39 ( 7 )   2006.07( ISSN:03869768

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  • 2397 潰瘍性大腸炎手術症例における手術部位感染(SSI)危険因子とその対策(感染症3,一般演題,第61回日本消化器外科学会定期学術総会) Reviewed

    前田 清, 西原 承浩, 井上 透, 野田 英児, 福永 真也, 山田 靖哉, 八代 正和, 西口 幸雄, 大平 雅一, 平川 弘聖

    一般社団法人日本消化器外科学会 日本消化器外科学会雑誌   39 ( 7 )   2006.07( ISSN:03869768

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  • 2240 胸部食道癌手術周術期における免疫強化栄養剤を用いた栄養管理の有用性について(栄養管理2,一般演題,第61回日本消化器外科学会定期学術総会) Reviewed

    大平 雅一, 山下 好人, 中川 泰生, 六車 一哉, 井上 透, 山田 靖哉, 八代 正和, 前田 清, 澤田 鉄二, 平川 弘聖

    一般社団法人日本消化器外科学会 日本消化器外科学会雑誌   39 ( 7 )   2006.07( ISSN:03869768

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  • 1211 消化器癌における癌遺伝子E-rasの発現とその制御に関する検討(分子生物学1,一般演題,第61回日本消化器外科学会定期学術総会) Reviewed

    安田 晃一, 八代 正和, 山下 好人, 山田 靖哉, 井上 透, 前田 清, 澤田 鉄二, 大平 雅一, 平川 弘聖

    一般社団法人日本消化器外科学会 日本消化器外科学会雑誌   39 ( 7 )   2006.07( ISSN:03869768

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  • 0970 切除不能・再発膵癌に対するGemcitabine化学療法における予後延長因子の検討(膵癌補助療法2,一般演題,第61回日本消化器外科学会定期学術総会) Reviewed

    天野 良亮, 山田 靖哉, 野田 英児, 八代 正和, 仲田 文造, 西口 幸雄, 大平 雅一, 加藤 保之, 西野 裕二, 平川 弘聖

    一般社団法人日本消化器外科学会 日本消化器外科学会雑誌   39 ( 7 )   2006.07( ISSN:03869768

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  • 0324 血管新生阻害剤Ki23057を用いた大腸癌の分子標的治療(大腸癌基礎1,一般演題,第61回日本消化器外科学会定期学術総会) Reviewed

    櫻井 克宣, 山田 靖哉, 八代 正和, 小松 みどり, 小野田 尚佳, 西口 幸雄, 石川 哲郎, 加藤 保之, 三輪 篤史, 平川 弘聖

    一般社団法人日本消化器外科学会 日本消化器外科学会雑誌   39 ( 7 )   2006.07( ISSN:03869768

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  • 0322 大腸癌におけるchemokine receptor CXCR4の発現とリンパ行性転移の検討(大腸癌基礎1,一般演題,第61回日本消化器外科学会定期学術総会) Reviewed

    福永 真也, 前田 清, 野田 英児, 西原 承浩, 井上 透, 山田 靖哉, 山下 好人, 八代 正和, 西口 幸雄, 平川 弘聖

    一般社団法人日本消化器外科学会 日本消化器外科学会雑誌   39 ( 7 )   2006.07( ISSN:03869768

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  • 0188 胃癌の進展とK-samII発現(胃分子生物2(研究),一般演題,第61回日本消化器外科学会定期学術総会) Reviewed

    豊川 貴弘, 八代 正和, 井上 透, 山田 靖哉, 西口 幸雄, 加藤 保之, 小野田 尚佳, 仲田 文造, 石川 哲郎, 平川 弘聖

    一般社団法人日本消化器外科学会 日本消化器外科学会雑誌   39 ( 7 )   2006.07( ISSN:03869768

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  • 0179 スキルス胃癌に対するTGFβ-R阻害剤を用いた分子標的治療(胃分子生物2(研究),一般演題,第61回日本消化器外科学会定期学術総会) Reviewed

    川尻 成美, 八代 正和, 竹村 哲, 西口 幸雄, 石川 哲郎, 加藤 保之, 宮園 浩平, 野出 学, 梶本 哲也, 平川 弘聖

    一般社団法人日本消化器外科学会 日本消化器外科学会雑誌   39 ( 7 )   2006.07( ISSN:03869768

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  • Synchronous Adenocarcinomas of the Ileum and Transverse Colon Detected by Capsule Endoscopy : Report of a Case Reviewed

    HOSONO SHUNSUKE, OHIRA MASAICHI, MAEDA KIYOSHI, MUGURUMA KAZUYA, NISHIHARA TAMAHIRO, INOUE TORU, YASHIRO MASAKAZU, HIRAKAWA KOSEI

    Surgery today : the Japanese journal of surgery   36 ( 7 )   663 - 665   2006.07( ISSN:09411291

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  • V-17-2 胃癌に対する胃全摘術後全端々吻合による空腸間置再建法について(胃3,ビデオセッション17,第61回日本消化器外科学会定期学術総会) Reviewed

    六車 一哉, 澤田 鉄二, 井上 透, 西原 承浩, 山下 好人, 八代 正和, 山田 靖哉, 大平 雅一, 石川 哲郎, 平川 弘聖

    一般社団法人日本消化器外科学会 日本消化器外科学会雑誌   39 ( 7 )   2006.07( ISSN:03869768

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  • W-1-1 頭頸部癌患者の上部消化管内視鏡スクリーニングで発見された食道重複癌の治療(同時性異時性重複癌の外科治療,ワークショップ,第61回日本消化器外科学会定期学術総会) Reviewed

    山下 好人, 大平 雅一, 阿古 英次, 久保 尚士, 六車 一哉, 井上 透, 八代 正和, 山田 靖哉, 澤田 鉄二, 平川 弘聖

    一般社団法人日本消化器外科学会 日本消化器外科学会雑誌   39 ( 7 )   2006.07( ISSN:03869768

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  • 0087 食道表在癌におけるリンパ節転移とVEGF-Cの発現および簇出との関連についての検討(食道表在癌・Barrett腺癌,一般演題,第61回日本消化器外科学会定期学術総会) Reviewed

    中川 泰生, 大平 雅一, 山下 好人, 野田 英児, 山田 靖哉, 八代 正和, 前田 清, 澤田 鉄二, 小野田 尚佳, 平川 弘聖

    日本消化器外科学会雑誌   39 ( 7 )   1047   2006.07( ISSN:03869768

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  • 2397 潰瘍性大腸炎手術症例における手術部位感染(SSI)危険因子とその対策(感染症3,一般演題,第61回日本消化器外科学会定期学術総会) Reviewed

    前田 清, 西原 承浩, 井上 透, 野田 英児, 福永 真也, 山田 靖哉, 八代 正和, 西口 幸雄, 大平 雅一, 平川 弘聖

    日本消化器外科学会雑誌   39 ( 7 )   1339   2006.07( ISSN:03869768

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  • 2240 胸部食道癌手術周術期における免疫強化栄養剤を用いた栄養管理の有用性について(栄養管理2,一般演題,第61回日本消化器外科学会定期学術総会) Reviewed

    大平 雅一, 山下 好人, 中川 泰生, 六車 一哉, 井上 透, 山田 靖哉, 八代 正和, 前田 清, 澤田 鉄二, 平川 弘聖

    日本消化器外科学会雑誌   39 ( 7 )   1320   2006.07( ISSN:03869768

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  • 1211 消化器癌における癌遺伝子E-rasの発現とその制御に関する検討(分子生物学1,一般演題,第61回日本消化器外科学会定期学術総会) Reviewed

    安田 晃一, 八代 正和, 山下 好人, 山田 靖哉, 井上 透, 前田 清, 澤田 鉄二, 大平 雅一, 平川 弘聖

    日本消化器外科学会雑誌   39 ( 7 )   1188   2006.07( ISSN:03869768

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  • 0970 切除不能・再発膵癌に対するGemcitabine化学療法における予後延長因子の検討(膵癌補助療法2,一般演題,第61回日本消化器外科学会定期学術総会) Reviewed

    天野 良亮, 山田 靖哉, 野田 英児, 八代 正和, 仲田 文造, 西口 幸雄, 大平 雅一, 加藤 保之, 西野 裕二, 平川 弘聖

    日本消化器外科学会雑誌   39 ( 7 )   1158   2006.07( ISSN:03869768

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  • 0324 血管新生阻害剤Ki23057を用いた大腸癌の分子標的治療(大腸癌基礎1,一般演題,第61回日本消化器外科学会定期学術総会) Reviewed

    櫻井 克宣, 山田 靖哉, 八代 正和, 小松 みどり, 小野田 尚佳, 西口 幸雄, 石川 哲郎, 加藤 保之, 三輪 篤史, 平川 弘聖

    日本消化器外科学会雑誌   39 ( 7 )   1077   2006.07( ISSN:03869768

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  • 0322 大腸癌におけるchemokine receptor CXCR4の発現とリンパ行性転移の検討(大腸癌基礎1,一般演題,第61回日本消化器外科学会定期学術総会) Reviewed

    福永 真也, 前田 清, 野田 英児, 西原 承浩, 井上 透, 山田 靖哉, 山下 好人, 八代 正和, 西口 幸雄, 平川 弘聖

    日本消化器外科学会雑誌   39 ( 7 )   1077   2006.07( ISSN:03869768

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  • 0188 胃癌の進展とK-samII発現(胃分子生物2(研究),一般演題,第61回日本消化器外科学会定期学術総会) Reviewed

    豊川 貴弘, 八代 正和, 井上 透, 山田 靖哉, 西口 幸雄, 加藤 保之, 小野田 尚佳, 仲田 文造, 石川 哲郎, 平川 弘聖

    日本消化器外科学会雑誌   39 ( 7 )   1060   2006.07( ISSN:03869768

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  • 0179 スキルス胃癌に対するTGFβ-R阻害剤を用いた分子標的治療(胃分子生物2(研究),一般演題,第61回日本消化器外科学会定期学術総会) Reviewed

    川尻 成美, 八代 正和, 竹村 哲, 西口 幸雄, 石川 哲郎, 加藤 保之, 宮園 浩平, 野出 学, 梶本 哲也, 平川 弘聖

    日本消化器外科学会雑誌   39 ( 7 )   1059   2006.07( ISSN:03869768

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  • Synchronous Adenocarcinomas of the Ileum and Transverse Colon Detected by Capsule Endoscopy : Report of a Case Reviewed

    HOSONO SHUNSUKE, OHIRA MASAICHI, MAEDA KIYOSHI, MUGURUMA KAZUYA, NISHIHARA TAMAHIRO, INOUE TORU, YASHIRO MASAKAZU, HIRAKAWA KOSEI

    36 ( 7 )   663 - 665   2006.07( ISSN:09411291

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  • W-1-1 頭頸部癌患者の上部消化管内視鏡スクリーニングで発見された食道重複癌の治療(同時性異時性重複癌の外科治療,ワークショップ,第61回日本消化器外科学会定期学術総会) Reviewed

    山下 好人, 大平 雅一, 阿古 英次, 久保 尚士, 六車 一哉, 井上 透, 八代 正和, 山田 靖哉, 澤田 鉄二, 平川 弘聖

    日本消化器外科学会雑誌   39 ( 7 )   981   2006.07( ISSN:03869768

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  • V-17-2 胃癌に対する胃全摘術後全端々吻合による空腸間置再建法について(胃3,ビデオセッション17,第61回日本消化器外科学会定期学術総会) Reviewed

    六車 一哉, 澤田 鉄二, 井上 透, 西原 承浩, 山下 好人, 八代 正和, 山田 靖哉, 大平 雅一, 石川 哲郎, 平川 弘聖

    日本消化器外科学会雑誌   39 ( 7 )   1027   2006.07( ISSN:03869768

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  • Synchronous adenocarcinomas of the ileum and transverse colon detected by capsule endoscopy: Report of a case Reviewed

    Hosono Shunsuke, Ohira Masaichi, Maeda Kiyoshi, Muguruma Kazuya, Nishihara Tamahiro, Inoue Toru, Yashiro Masakazu, Hirakawa Kosei

    SURGERY TODAY   36 ( 7 )   663 - 665   2006.07( ISSN:0941-1291

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    DOI: 10.1007/s00595-006-3207-8

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  • Mechanisms responsible for peritoneal dissemination and molecular targeting Reviewed

    61 ( 6 )   733 - 740   2006.06( ISSN:03869857 ( eISSN:18821278

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    DOI: 10.11477/mf.1407100461

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  • Two Cases Report of the Crohn's Disease that formed Colonic-Duodenal Fistula Reviewed

    NODA Eiji, MAEDA Kiyoshi, INOUE Toru, NISHIHARA Tamahiro, YASHIRO Masakazu, YAMADA Nobuya, YAMASHITA Yoshito, SAWADA Tetsuji, OHIRA Masaichi, HIRAKAWA Kosei

    The Japanese Society of Gastroenterological Surgery, The Japanese journal of gastroenterological surgery   39 ( 5 )   608 - 613   2006.05( ISSN:03869768

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    We reported two cases of Crohn's disease associated with duodenal colonic fistulas treated surgical. Case 1; A 35-year-old man admitted for right-side hypochondralgia and anal pain was found in gastrointestinal endoscopy to have stenosis at the second portion of the duodenum. Upper gastrointestinal X-ray showed stenosis at the terminal ileum and a fistula between the caecum and terminal ileum. Fistulography confirmed a fistula between the duodenal bulb and terminal colon. Abdominal CT showed that an abscess had formed in the hepatic circumference. Case 2; A 23-year-old man seen for pyrexia and anal pain and having a 9-year history of Crohn's disease underwent colonic stenosis. Five years after the operation, colonoscopy and fistelography showed a fistula between the transverse colon and duodenum. Conservative preoperative treatment failed to close the fistulas necessitating transverse colon resection in case 2. Both men required fistulectomy, simple closure of the duodenal component of the fistulas and omental patching.

    CiNii Article

  • Two Cases Report of the Crohn's Disease that formed Colonic-Duodenal Fistula Reviewed

    NODA Eiji, MAEDA Kiyoshi, INOUE Toru, NISHIHARA Tamahiro, YASHIRO Masakazu, YAMADA Nobuya, YAMASHITA Yoshito, SAWADA Tetsuji, OHIRA Masaichi, HIRAKAWA Kosei

    The Japanese journal of gastroenterological surgery   39 ( 5 )   608 - 613   2006.05( ISSN:03869768

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    We reported two cases of Crohn's disease associated with duodenal colonic fistulas treated surgical. Case 1; A 35-year-old man admitted for right-side hypochondralgia and anal pain was found in gastrointestinal endoscopy to have stenosis at the second portion of the duodenum. Upper gastrointestinal X-ray showed stenosis at the terminal ileum and a fistula between the caecum and terminal ileum. Fistulography confirmed a fistula between the duodenal bulb and terminal colon. Abdominal CT showed that an abscess had formed in the hepatic circumference. Case 2; A 23-year-old man seen for pyrexia and anal pain and having a 9-year history of Crohn's disease underwent colonic stenosis. Five years after the operation, colonoscopy and fistelography showed a fistula between the transverse colon and duodenum. Conservative preoperative treatment failed to close the fistulas necessitating transverse colon resection in case 2. Both men required fistulectomy, simple closure of the duodenal component of the fistulas and omental patching.

    CiNii Article

  • スキルス胃癌細胞の組織形成と進展における胃癌細胞と間質細胞の相互作用因子の同定及び解析 Reviewed

    児玉 良典, 大沼 和弘, 仙波 秀峰, 伊藤 彰彦, 八代 正和, 平川 弘聖, 横崎 宏

    日本病理学会会誌   95 ( 1 )   330 - 330   2006.04( ISSN:0300-9181

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  • Preclinical study of a "tailor-made" combination of NK4-expressing gene therapy and getitinib (ZD1839, Iressa (TM)) for disseminated peritoneal scirrhous gastric cancer Reviewed

    Namiki Y, Namiki T, Yoshida H, Date M, Yashiro M, Matsumoto K, Nakamura T, Yanagihara K, Tada N, Satoi J, Fujise K

    INTERNATIONAL JOURNAL OF CANCER   118 ( 6 )   1545 - 1555   2006.03( ISSN:0020-7136

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    DOI: 10.1002/ijc.21531

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  • Keratinocyte growth factor receptor (KGFR)をターゲットにした胆道癌に対する分子標的治療の可能性についての検討 Reviewed

    天野 良亮, 山田 靖哉, 八代 正和, 中村 和憲, 豊川 貴弘, 大平 雅一, 西野 裕二, 三輪 篤史, 平川 弘聖

    一般社団法人日本外科学会 日本外科学会雑誌   107 ( 2 )   2006.03( ISSN:03014894

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  • TRAILによる胃癌治療効果予測因子としてのcaspase-8蛋白活性の検討 Reviewed

    仲田 文造, 金原 功, 八代 正和, 大平 雅一, 平川 弘聖

    一般社団法人日本外科学会 日本外科学会雑誌   107 ( 2 )   2006.03( ISSN:03014894

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  • Ki23057を用いた大腸癌に対する血管新生阻害剤治療 Reviewed

    櫻井 克宣, 山田 靖哉, 八代 正和, 六車 一哉, 高島 勉, 井上 透, 西原 承浩, 山下 好人, 前田 清, 小野田 尚佳, 澤田 鉄二, 仲田 文造, 大平 雅一, 石川 哲郎, 西野 裕二, 三輪 篤史, 平川 弘聖

    一般社団法人日本外科学会 日本外科学会雑誌   107 ( 2 )   2006.03( ISSN:03014894

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  • 新規ヒト化抗膵癌ムチン抗体の作製とその基礎的解析 Reviewed

    木村 健二郎, 澤田 鉄二, 小松 みどり, 六車 一哉, 西原 承浩, 山下 好人, 八代 正和, 山田 靖哉, 加藤 保之, 平川 弘聖, 鈴木 定彦

    一般社団法人日本外科学会 日本外科学会雑誌   107 ( 2 )   2006.03( ISSN:03014894

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  • 進行再発食道癌に対するDocetaxel, Nedaplatin, 5-Fu併用化学療法の有用性について Reviewed

    大平 雅一, 山下 好人, 中川 泰生, 六車 一哉, 井上 透, 西原 承浩, 山田 靖哉, 八代 正和, 前田 清, 小野田 尚佳, 澤田 鉄二, 西口 幸雄, 石川 哲郎, 加藤 保之, 平川 弘聖

    一般社団法人日本外科学会 日本外科学会雑誌   107 ( 2 )   2006.03( ISSN:03014894

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  • 胃癌切除症例におけるK-sam発現の免疫組織学的検討 Reviewed

    豊川 貴弘, 八代 正和, 井上 透, 西原 承浩, 山下 好人, 山田 靖哉, 小野田 尚佳, 前田 清, 澤田 鉄二, 仲田 文造, 大平 雅一, 石川 哲郎, 西野 裕二, 平川 弘聖

    一般社団法人日本外科学会 日本外科学会雑誌   107 ( 2 )   2006.03( ISSN:03014894

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  • 胃癌の増殖形態とK-ras変異 Reviewed

    八代 正和, 西岡 伸明, 澤田 鉄二, 山田 靖哉, 前田 清, 井上 透, 仲田 文造, 西口 幸雄, 大平 雅一, 石川 哲朗, 加藤 保之, 平川 弘聖

    一般社団法人日本外科学会 日本外科学会雑誌   107 ( 2 )   2006.03( ISSN:03014894

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  • 直腸癌局所再発の臨床病理学的検討およびその予測因子としてのVEGF-C (vascular endothelial growth factor-C)発現 Reviewed

    野田 英児, 前田 清, 井上 透, 高島 勉, 六車 一哉, 西原 承浩, 山田 靖哉, 八代 正和, 山下 好人, 小野田 尚佳, 澤田 鉄二, 仲田 文造, 大平 雅一, 石川 哲郎, 西口 幸雄, 加藤 保之, 西野 裕二, 平川 弘聖

    一般社団法人日本外科学会 日本外科学会雑誌   107 ( 2 )   2006.03( ISSN:03014894

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  • 潰瘍性大腸炎に対するHand-assisted laparoscopic surgery : 特に緊急手術例に対する適応拡大 Reviewed

    前田 清, 西原 承浩, 井上 透, 野田 英児, 福永 真也, 八代 正和, 山田 靖哉, 山下 好人, 小野田 尚佳, 西口 幸雄, 平川 弘聖

    一般社団法人日本外科学会 日本外科学会雑誌   107 ( 2 )   2006.03( ISSN:03014894

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  • 消化器癌における癌遺伝子E-rasの発現とその制御 Reviewed

    安田 晃一, 八代 正和, 山下 好人, 山田 靖哉, 井上 透, 前田 清, 澤田 鉄二, 大平 雅一, 仲田 文造, 平川 弘聖

    一般社団法人日本外科学会 日本外科学会雑誌   107 ( 2 )   2006.03( ISSN:03014894

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    CiNii Article

  • Keratinocyte growth factor receptor (KGFR)をターゲットにした胆道癌に対する分子標的治療の可能性についての検討 Reviewed

    天野 良亮, 山田 靖哉, 八代 正和, 中村 和憲, 豊川 貴弘, 大平 雅一, 西野 裕二, 三輪 篤史, 平川 弘聖

    日本外科学会雑誌   107 ( 2 )   698   2006.03( ISSN:03014894

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    CiNii Article

  • Ki23057を用いた大腸癌に対する血管新生阻害剤治療 Reviewed

    櫻井 克宣, 山田 靖哉, 八代 正和, 六車 一哉, 高島 勉, 井上 透, 西原 承浩, 山下 好人, 前田 清, 小野田 尚佳, 澤田 鉄二, 仲田 文造, 大平 雅一, 石川 哲郎, 西野 裕二, 三輪 篤史, 平川 弘聖

    日本外科学会雑誌   107 ( 2 )   403   2006.03( ISSN:03014894

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  • TRAILによる胃癌治療効果予測因子としてのcaspase-8蛋白活性の検討 Reviewed

    仲田 文造, 金原 功, 八代 正和, 大平 雅一, 平川 弘聖

    日本外科学会雑誌   107 ( 2 )   307   2006.03( ISSN:03014894

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  • 新規ヒト化抗膵癌ムチン抗体の作製とその基礎的解析 Reviewed

    木村 健二郎, 澤田 鉄二, 小松 みどり, 六車 一哉, 西原 承浩, 山下 好人, 八代 正和, 山田 靖哉, 加藤 保之, 平川 弘聖, 鈴木 定彦

    日本外科学会雑誌   107 ( 2 )   563   2006.03( ISSN:03014894

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  • 進行再発食道癌に対するDocetaxel, Nedaplatin, 5-Fu併用化学療法の有用性について Reviewed

    大平 雅一, 山下 好人, 中川 泰生, 六車 一哉, 井上 透, 西原 承浩, 山田 靖哉, 八代 正和, 前田 清, 小野田 尚佳, 澤田 鉄二, 西口 幸雄, 石川 哲郎, 加藤 保之, 平川 弘聖

    日本外科学会雑誌   107 ( 2 )   433   2006.03( ISSN:03014894

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  • 胃癌切除症例におけるK-sam発現の免疫組織学的検討 Reviewed

    豊川 貴弘, 八代 正和, 井上 透, 西原 承浩, 山下 好人, 山田 靖哉, 小野田 尚佳, 前田 清, 澤田 鉄二, 仲田 文造, 大平 雅一, 石川 哲郎, 西野 裕二, 平川 弘聖

    日本外科学会雑誌   107 ( 2 )   361   2006.03( ISSN:03014894

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  • 胃癌の増殖形態とK-ras変異 Reviewed

    八代 正和, 西岡 伸明, 澤田 鉄二, 山田 靖哉, 前田 清, 井上 透, 仲田 文造, 西口 幸雄, 大平 雅一, 石川 哲朗, 加藤 保之, 平川 弘聖

    日本外科学会雑誌   107 ( 2 )   363   2006.03( ISSN:03014894

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  • 直腸癌局所再発の臨床病理学的検討およびその予測因子としてのVEGF-C (vascular endothelial growth factor-C)発現 Reviewed

    野田 英児, 前田 清, 井上 透, 高島 勉, 六車 一哉, 西原 承浩, 山田 靖哉, 八代 正和, 山下 好人, 小野田 尚佳, 澤田 鉄二, 仲田 文造, 大平 雅一, 石川 哲郎, 西口 幸雄, 加藤 保之, 西野 裕二, 平川 弘聖

    日本外科学会雑誌   107 ( 2 )   724   2006.03( ISSN:03014894

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  • 潰瘍性大腸炎に対するHand-assisted laparoscopic surgery : 特に緊急手術例に対する適応拡大 Reviewed

    前田 清, 西原 承浩, 井上 透, 野田 英児, 福永 真也, 八代 正和, 山田 靖哉, 山下 好人, 小野田 尚佳, 西口 幸雄, 平川 弘聖

    日本外科学会雑誌   107 ( 2 )   200   2006.03( ISSN:03014894

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  • 消化器癌における癌遺伝子E-rasの発現とその制御 Reviewed

    安田 晃一, 八代 正和, 山下 好人, 山田 靖哉, 井上 透, 前田 清, 澤田 鉄二, 大平 雅一, 仲田 文造, 平川 弘聖

    日本外科学会雑誌   107 ( 2 )   602   2006.03( ISSN:03014894

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  • Carcinogenesis in the remnant stomach following distal gastrectomy with billroth II reconstruction is associated with high-level microsatellite instability. Reviewed

    Aya M, Yashiro M, Nishioka N, Onoda N, Hirakawa K

    Anticancer research   26 ( 2B )   1403 - 11   2006.03( ISSN:0250-7005

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    PubMed

  • Frequent p16 CpG island hypermethylation in primary remnant gastric cancer suggesting an independent carcinogenic pathway. Reviewed

    Mino A, Onoda N, Yashiro M, Aya M, Fujiwara I, Kubo N, Sawada T, Ohira M, Kato Y, Hirakawa K

    Oncology reports   15 ( 3 )   615 - 20   2006.03( ISSN:1021-335X

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    PubMed

  • Frequent p16 CpG island hypermethylation in primary remnant gastric cancer suggesting an independent carcinogenic pathway Reviewed

    Mino A, Onoda N, Yashiro M, Aya M, Fujiwara I, Kubo N, Sawada T, Ohira M, Kato Y, Hirakawa K

    ONCOLOGY REPORTS   15 ( 3 )   615 - 620   2006.03( ISSN:1021-335X

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  • Frequent p16 CpG island hypermethylation in primary remnant gastric cancer suggesting an independent carcinogenic pathway Reviewed

    A Mino, N Onoda, M Yashiro, M Aya, Fujiwara, I, N Kubo, T Sawada, M Ohira, Y Kato, K Hirakawa

    ONCOLOGY REPORTS   15 ( 3 )   615 - 620   2006.03( ISSN:1021-335X

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    Cancer found in the post-operative remnant stomach includes both newly developed cancer after surgery for benign-disease (PRC) and metachronous multiple cancer (MRC). Differences in the carcinogenic pathway between PRC and MRC have been suspected from clinical studies. However, no study has demonstrated the difference in molecular alteration between these diseases. P16 is inactivated predominantly by epigenetic change, rather than genetic alteration. We analyzed the methylation status and protein expression of the p16 gene in cancers of the remnant stomach. Eleven lesions of PRC, 24 lesions of MRC and corresponding non-cancerous tissue, as well as 13 primary gastric cancer (PC) lesions were examined. DNA was extracted by the micro-dissection method from paraffin-embedded surgical specimens. The methylation status of the promoter CpG island of the p16 gene was examined by using a methylation-specific polymerase chain reaction technique. To detect protein expression, immunohistochemical staining was employed. p16 promoter hypermethylation was observed more often in remnant gastric cancer than in PC. A significantly more frequent hypermethylation in the p16 gene was found in PRC (64%) than in MRC (21%) or PC (23%). Moreover, a significant correlation was found between p16 promoter hypermethylation and diminishment of protein expression in cancers of the remnant stomach. Silencing of the p16 gene by methylation of its promoter CpG island was suggested as a unique molecular mechanism in the carcinogenesis of PRC compared with MRC or PC.

    PubMed

  • Frequent p16 CpG island hypermethylation in primary remnant gastric cancer suggesting an independent carcinogenic pathway. Reviewed

    Mino A, Onoda N, Yashiro M, Aya M, Fujiwara I, Kubo N, Sawada T, Ohira M, Kato Y, Hirakawa K

    Oncology reports   15 ( 3 )   615 - 20   2006.03( ISSN:1021-335X

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    PubMed

  • Carcinogenesis in the remnant stomach following distal gastrectomy with billroth II reconstruction is associated with high-level microsatellite instability Reviewed

    M Aya, M Yashiro, N Nishioka, N Onoda, K Hirakawa

    ANTICANCER RESEARCH   26 ( 2B )   1403 - 1411   2006.03( ISSN:0250-7005

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    Although the gastric remnant has been reported to be at high risk for carcinogenesis, the process of carcinogenesis of gastric remnant cancer (GRC) remains unclear. In this study, genetic alterations in GRC were examined in order to investigate the carcinogenic pathways of GRC Twenty-one patients with GRC were investigated and were compared to 36 patients with sporadic gastric cancer (GC) as a control group. Microsatellite instability (MSI) was examined using 8 primer marker sets. Immunohistochemical staining for hMLH1 and hMSH2 as the DNA mismatch repair system was performed. The high-level MSI (MSI-H) frequency (43%; 9/21) of GRC was significantly higher (p = 0.001) than that of the sporadic GC (6%; 2/36). The MSI-H incidence (67%: 8/12) of GRC after gastrojejunostomy (Billroth II anastomosis) was significantly (p = 0.015) higher than that (11%: 1/9) after gastroduodenostomy (Billroth I anastomosis). The MSI-H in GRC was significantly (p &lt; 0.0001) associated with lack of expression of both hMLH1 and hMSH2. The inactivation of hMLH1 or hMSH2 was significantly frequent (p = 0.035) in GRC after gastrojejunostomy (58%: 7/12), compared with that in gastroduodenostomy (11%: 1/9). GRC was more closely associated with the MSI pathway than sporadic GC. Carcinogenesis in the remnant stomach following distal gastrectomy with gastrojejunostomy was found to be associated with the MSI pathway due to inactivation of the DNA mismatch repair system.

    PubMed

  • Preclinical study of a "tailor-made" combination of NK4-expressing gene therapy and getitinib (ZD1839, Iressa (TM)) for disseminated peritoneal scirrhous gastric cancer Reviewed

    Y Namiki, T Namiki, H Yoshida, M Date, M Yashiro, K Matsumoto, T Nakamura, K Yanagihara, N Tada, J Satoi, K Fujise

    INTERNATIONAL JOURNAL OF CANCER   118 ( 6 )   1545 - 1555   2006.03( ISSN:0020-7136

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    We evaluated the effect of a "tailor-made" chemo-gene therapy in scirrhous gastric cancer (SGC)-bearing nude mice. For this tailor-made approach, we first selected gefitinib (epidermal growth factor receptor-tyrosine kinase inhibitor)-sensitive SGC cell lines, and 5/8 cell lines demonstrated various degrees of gefitinib-sensitivity. In the highly gefitinib-sensitive NUGG4, the biological response to NK4 (HGF antagonist/angiogenesis inhibitor) was examined. Subsequently, the composition of an NK4-expressing ternary complex (cationic lipid/nucleic acid/HMG-1, 2 protein) was optimized for maximum transfection activity in NUGG4. Finally, mice were peritoneally coinoculated with NUGG4 and scirrhous-associated gastric fibroblasts, NF22, on day 0. Animal models were orally administrated gefitinib (50 mg/kg/day, on days 7-28), and peritoneally NK4-expressing ternary complex (on days 14, 21 and 28). NK4-expression suppressed the gefitinib-resistance induced by the interaction between fibroblasts and SGC, and eventually. this tailor-made combination synergistically decelerated the disease progression by inhibiting proliferative, angiogenic and antiapoptotic effects in tumor tissues. On day 28, both the hemoglobin concentration (g/dl) (control (n = 8), 11.9; treated (n = 8) 17.3; p = 0.0014) and the numbers of mice in good condition (control, 2: treated, 8; p = 0.0012) were significantly greater, and the abdominal girth (turn) (control, 81.1; treated, 0.3; p = 0.0036) was significantly reduced. The median points of bloody ascite-free survival time (days) (control, 22; treated, 44; p &lt; 0.0001) and time to euthanasia (days) (control, 36.5; treated, 56; p &lt; 0.0001) were also significantly prolonged. This combination is a potentially useful approach to the treatment of peritoneal gefitinib-sensitive SGC dissemination. (c) 2005 Wiley-Liss. Inc.

    DOI: 10.1002/ijc.21531

    PubMed

  • Carcinogenesis in the remnant stomach following distal gastrectomy with billroth II reconstruction is associated with high-level microsatellite instability. Reviewed

    Aya M, Yashiro M, Nishioka N, Onoda N, Hirakawa K

    Anticancer research   26 ( 2B )   1403 - 11   2006.03( ISSN:0250-7005

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  • Laparoscope-assisted Small Laparotomy Surgery for Ulcerative Colitis Under Emergency Operation Conditions Reviewed

    INOUE Toru, MAEDA Kiyoshi, YASHIRO Masakazu, NISHIHARA Tamahiro, NISHIGUCHI Yukio, HIRAKAWA Kosei

    26 ( 1 )   43 - 46   2006.01( ISSN:13402242

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    CiNii Article

  • Laparoscope-assisted Small Laparotomy Surgery for Ulcerative Colitis Under Emergency Operation Conditions Reviewed

    INOUE Toru, MAEDA Kiyoshi, YASHIRO Masakazu, NISHIHARA Tamahiro, NISHIGUCHI Yukio, HIRAKAWA Kosei

    26 ( 1 )   43 - 46   2006.01( ISSN:13402242

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  • Decreased expression of the adhesion molecule desmoglein-2 is associated with diffuse-type gastric carcinoma.

    Eur J Cancer.   42   2397   2006

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  • A novel molecular targeting compound as K-samII/FGF-R2 phosphorylation inhibitor, Ki23057, for Scirrhous gastric cancer.

    Gastroenterology   131   1530   2006

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  • Carcinogenesis in the remnant stomach following distal gastrectomy with billroth II reconstruction is associated with high-level microsatellite instability Reviewed

    Aya M, Yashiro M, Nishioka N, Onoda N, Hirakawa K

    ANTICANCER RESEARCH   26 ( 2B )   1403 - 1411   2006( ISSN:0250-7005

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  • Investigation of utility of preoperative CEA (Carcinoembryonic antigen) as a predictor of local recurrence of rectal cancer Reviewed

    Noda Eiji, Onoda Naoyoshi, Sawada Tetsuji, Nakata Bunzo, Ohira Masaichi, Ishikawa Tetsuro, Nishino Hiroji, Hirakawa Kosei, Maeda Kiyoshi, Amano Ryosuke, Muguruma Kazuya, Inoue Toru, Nishihara Tamahiro, Yamada Nobuya, Yashiro Masakazu, Yamashita Yoshito

    Japanese Society for Molecular Tumor Marker Research, Japan Journal of Molecular Tumor Marker Research   21 ( 0 )   17 - 18   2006

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    DOI: 10.11241/jsmtmr.21.17

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  • The change of serum SPan-1 levels may predict the improvement of prognosis by gemcitabine in pancreatic cancer Reviewed

    Amano Ryosuke, Ohira Masaichi, Ishikawa Tetsuo, Nishino Hirozi, Hirakawa Kosei, Nakata Bunzo, Tendo Masashige, Noda Eizi, Yamada Nobuya, Yashiro Masakazu, Maeda Kiyoshi, Onoda Naoyosh, Sawada Tetsuzi

    Japanese Society for Molecular Tumor Marker Research, Japan Journal of Molecular Tumor Marker Research   21 ( 0 )   15 - 16   2006

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    DOI: 10.11241/jsmtmr.21.15

    CiNii Article

  • Laparoscope-assisted Small Laparotomy Surgery for Ulcerative Colitis Under Emergency Operation Conditions Reviewed

    Inoue Toru, Maeda Kiyoshi, Yashiro Masakazu, Nishihara Tamahiro, Nishiguchi Yukio, Hirakawa Kosei

    Japanese Society for Abdominal Emergency Medicine, Nihon Fukubu Kyukyu Igakkai Zasshi (Journal of Abdominal Emergency Medicine)   26 ( 1 )   43 - 46   2006( ISSN:1340-2242

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    Laparoscopic operation for ulcerative colitis is less invasive but still takes too long compared with laparotomy surgery. We have therefore reported the usefulness of the laparoscopy-assisted small laparotomy operation. From 2001 to 2005, we performed the laparoscopy assisted operation for 36 patients with ulcerative colitis. Ten of them were under emergency operation conditions, consisting of total colectomy and ileostomy. Most of the operative procedures were performed from small a laparotomy incision placed in the hypogastrium. Hepatic flexure, splenic flexure and mesocolon of the transverse colon were treated under hand assisted laparoscopic conditions. The bowel in patients with ulcerative colitis is usually too weak to manipulate firmly with forceps, so the hand-assisted method was useful and safe to treat the bowl in these patients. The mean operating time was 205 minutes and intraoperative blood loss was 87 ml. Most of the patients started ingestion within a few days postoperatively. Ileus occurred in one patient, but it resolved spontaneously without surgical treatment. This operative approach has the characteristics not only of the low invasiveness associated with laparoscopic surgery, but also its inherent safety. Even under emergency operation conditions, laparoscopic assisted surgery was useful in patients who were in good general condition.

    DOI: 10.11231/jaem1993.26.43

    CiNii Article

  • Two Cases Report of the Crohn's Disease that formed Colonic-Duodenal Fistula Reviewed

    Noda Eiji, Hirakawa Kosei, Maeda Kiyoshi, Inoue Toru, Nishihara Tamahiro, Yashiro Masakazu, Yamada Nobuya, Yamashita Yoshito, Sawada Tetsuji, Ohira Masaichi

    The Japanese Society of Gastroenterological Surgery, The Japanese Journal of Gastroenterological Surgery   39 ( 5 )   608 - 613   2006( ISSN:0386-9768

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    We reported two cases of Crohn.s disease associated with duodenal colonic fistulas treated surgical. Case 1; A 35-year-old man admitted for right-side hypochondralgia and anal pain was found in gastrointestinal endoscopy to have stenosis at the second portion of the duodenum. Upper gastrointestinal X-ray showed stenosis at the terminal ileum and a fistula between the caecum and terminal ileum. Fistulography confirmed a fistula between the duodenal bulb and terminal colon. Abdominal CT showed that an abscess had formed in the hepatic circumference. Case 2; A 23-year-old man seen for pyrexia and anal pain and having a 9-year history of Crohn's disease underwent colonic stenosis. Five years after the operation, colonoscopy and fistelography showed a fistula between the transverse colon and duodenum. Conservative preoperative treatment failed to close the fistulas necessitating transverse colon resection in case 2. Both men required fistulectomy, simple closure of the duodenal component of the fistulas and omental patching.

    DOI: 10.5833/jjgs.39.608

    CiNii Article

  • Synchronous adenocarcinomas of the ileum and transverse colon detected by capsule endoscopy: Report of a case Reviewed

    S Hosono, M Ohira, K Maeda, K Muguruma, T Nishihara, T Inoue, M Yashiro, K Hirakawa

    SURGERY TODAY   36 ( 7 )   663 - 5   2006( ISSN:0941-1291

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    A 77-year-old woman was admitted to our hospital with anemia and anorexia. Neither gastrointestinal endoscopy nor computed tomography showed by abnormal findings; however, a capsule endoscopy, performed to detect obscure gastrointestinal bleeding, revealed a tumor in the ileum. When we tried to take biopsies of the ileal tumor by push enteroscopy via the anus, we found another tumor in the transverse colon. On exploration, tumors were identified in the ileum and the transverse colon. Thus, we resected the ileum and transverse colon with regional lymph node dissection. Histologic sections from both the ileum and colon revealed moderately differentiated adenocarcinomas with no lymph node metastasis.

    DOI: 10.1007/s00595-006-3207-8

    PubMed

  • スキルス胃癌における縁組化は癌の進展にどのようにかかわるのか? Reviewed

    八代 正和, 平川 弘聖

    分子消化器病 3巻3号   245 - 250   2006

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  • スキルス胃癌における線維化は癌の進展にどのようにかかわるのか? Reviewed

    八代 正和

    分子消化器病 3巻3号   245 - 250   2006

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  • TGF-beta1 down-regulates ICAM-1 expression and enhances liver metastasis of pancreatic cancer. Reviewed

    Sawada T, Kimura K, Nishihara T, Onoda N, Teraoka H, Yamashita Y, Yamada N, Yashiro M, Ohira M, Hirakawa K

    Advances in medical sciences   51   60 - 5   2006( ISSN:1896-1126

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    PubMed

  • Investigation of utility of preoperative CEA (Carcinoembryonic antigen) as a predictor of local recurrence of rectal cancer Reviewed

    Noda Eiji, Maeda Kiyoshi, Amano Ryosuke, Muguruma Kazuya, Inoue Toru, Nishihara Tamahiro, Yamada Nobuya, Yashiro Masakazu, Yamashita Yoshito, Onoda Naoyoshi, Sawada Tetsuji, Nakata Bunzo, Ohira Masaichi, Ishikawa Tetsuro, Nishino Hiroji, Hirakawa Kosei

    Japan Journal of Molecular Tumor Marker Research   21 ( 0 )   17 - 18   2006( eISSN:24338575

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    DOI: 10.11241/jsmtmr.21.17

    CiNii Article

  • The change of serum SPan-1 levels may predict the improvement of prognosis by gemcitabine in pancreatic cancer Reviewed

    Amano Ryosuke, Nakata Bunzo, Tendo Masashige, Noda Eizi, Yamada Nobuya, Yashiro Masakazu, Maeda Kiyoshi, Onoda Naoyosh, Sawada Tetsuzi, Ohira Masaichi, Ishikawa Tetsuo, Nishino Hirozi, Hirakawa Kosei

    Japan Journal of Molecular Tumor Marker Research   21 ( 0 )   15 - 16   2006( eISSN:24338575

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    DOI: 10.11241/jsmtmr.21.15

    CiNii Article

  • Laparoscope-assisted Small Laparotomy Surgery for Ulcerative Colitis Under Emergency Operation Conditions Reviewed

    Inoue Toru, Maeda Kiyoshi, Yashiro Masakazu, Nishihara Tamahiro, Nishiguchi Yukio, Hirakawa Kosei

    Nihon Fukubu Kyukyu Igakkai Zasshi (Journal of Abdominal Emergency Medicine)   26 ( 1 )   43 - 46   2006( ISSN:13402242 ( eISSN:18824781

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    Publishing type:Research paper (scientific journal)  

    Laparoscopic operation for ulcerative colitis is less invasive but still takes too long compared with laparotomy surgery. We have therefore reported the usefulness of the laparoscopy-assisted small laparotomy operation. From 2001 to 2005, we performed the laparoscopy assisted operation for 36 patients with ulcerative colitis. Ten of them were under emergency operation conditions, consisting of total colectomy and ileostomy. Most of the operative procedures were performed from small a laparotomy incision placed in the hypogastrium. Hepatic flexure, splenic flexure and mesocolon of the transverse colon were treated under hand assisted laparoscopic conditions. The bowel in patients with ulcerative colitis is usually too weak to manipulate firmly with forceps, so the hand-assisted method was useful and safe to treat the bowl in these patients. The mean operating time was 205 minutes and intraoperative blood loss was 87 ml. Most of the patients started ingestion within a few days postoperatively. Ileus occurred in one patient, but it resolved spontaneously without surgical treatment. This operative approach has the characteristics not only of the low invasiveness associated with laparoscopic surgery, but also its inherent safety. Even under emergency operation conditions, laparoscopic assisted surgery was useful in patients who were in good general condition.

    DOI: 10.11231/jaem1993.26.43

    CiNii Article

  • Two Cases Report of the Crohn's Disease that formed Colonic-Duodenal Fistula

    Noda Eiji, Maeda Kiyoshi, Inoue Toru, Nishihara Tamahiro, Yashiro Masakazu, Yamada Nobuya, Yamashita Yoshito, Sawada Tetsuji, Ohira Masaichi, Hirakawa Kosei

    The Japanese Journal of Gastroenterological Surgery   39 ( 5 )   608 - 613   2006( ISSN:03869768 ( eISSN:13489372

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    We reported two cases of Crohn.s disease associated with duodenal colonic fistulas treated surgical. Case 1; A 35-year-old man admitted for right-side hypochondralgia and anal pain was found in gastrointestinal endoscopy to have stenosis at the second portion of the duodenum. Upper gastrointestinal X-ray showed stenosis at the terminal ileum and a fistula between the caecum and terminal ileum. Fistulography confirmed a fistula between the duodenal bulb and terminal colon. Abdominal CT showed that an abscess had formed in the hepatic circumference. Case 2; A 23-year-old man seen for pyrexia and anal pain and having a 9-year history of Crohn's disease underwent colonic stenosis. Five years after the operation, colonoscopy and fistelography showed a fistula between the transverse colon and duodenum. Conservative preoperative treatment failed to close the fistulas necessitating transverse colon resection in case 2. Both men required fistulectomy, simple closure of the duodenal component of the fistulas and omental patching.

    DOI: 10.5833/jjgs.39.608

    CiNii Article

  • CD54 expression is predictive for lymphatic spread in human gastric carcinoma Reviewed

    Yashiro M, Sunami T, Hirakawa K

    DIGESTIVE DISEASES AND SCIENCES   50 ( 12 )   2224 - 2230   2005.12( ISSN:0163-2116

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    DOI: 10.1007/s10620-005-3039-1

    PubMed

  • Plasminogen activator inhibitor-1 (PAI-1) gene transfection inhibits the liver metastasis of pancreatic cancer by preventing angiogenesis. Reviewed

    Inoue M, Sawada T, Uchima Y, Kimura K, Nishihara T, Tanaka H, Yashiro M, Yamada N, Ohira M, Hirakawa K

    Oncology reports   14 ( 6 )   1445 - 51   2005.12( ISSN:1021-335X

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    PubMed

  • Plasminogen activator inhibitor-1 (PAI-1) gene transfection inhibits the liver metastasis of pancreatic cancer by preventing angiogenesis Reviewed

    Inoue M, Sawada T, Uchima Y, Kimura K, Nishihara T, Tanaka H, Yashiro M, Yamada N, Ohira M, Hirakawa K

    ONCOLOGY REPORTS   14 ( 6 )   1445 - 1451   2005.12( ISSN:1021-335X

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  • CD54 expression is predictive for lymphatic spread in human gastric carcinoma Reviewed

    M Yashiro, T Sunami, K Hirakawa

    DIGESTIVE DISEASES AND SCIENCES   50 ( 12 )   2224 - 30   2005.12( ISSN:0163-2116

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    Even among gastric carcinoma cases with a similar extent of lymphatic invasion, the number of diseased lymph nodes may vary. Other factors might also contribute to the process of lymphangitic metastasis. Primary gastric tumors with the same extent of pathologic lymphatic invasion were studied in 78 patients. We investigated the correlation between CD54 expression on cancer cells and clinicopathologic features. Decreased CD54 expression on cancer cells was significantly correlated with the number of involved lymph nodes and the extent of lymph node spread. The number of diseased lymph nodes was associated with the prognosis of patients with gastric carcinoma. The CD54-negative group had a significantly worse prognosis than the CD54-positive group. These findings suggested that CD54 expression is predictive for lymphatic spread and prognosis in human gastric carcinoma.

    DOI: 10.1007/s10620-005-3039-1

    PubMed

  • Plasminogen activator inhibitor-1 (PAI-1) gene transfection inhibits the liver metastasis of pancreatic cancer by preventing angiogenesis. Reviewed

    Inoue M, Sawada T, Uchima Y, Kimura K, Nishihara T, Tanaka H, Yashiro M, Yamada N, Ohira M, Hirakawa K

    Oncology reports   14 ( 6 )   1445 - 51   2005.12( ISSN:1021-335X

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    PubMed

  • Plasminogen activator inhibitor-1 (PAI-1) gene transfection inhibits the liver metastasis of pancreatic cancer by preventing angiogenesis Reviewed

    M Inoue, T Sawada, Y Uchima, K Kimura, T Nishihara, H Tanaka, M Yashiro, N Yamada, M Ohira, K Hirakawa

    ONCOLOGY REPORTS   14 ( 6 )   1445 - 1451   2005.12( ISSN:1021-335X

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    Plasminogen activator inhibitor-1 (PAI-1) is a unique type of serine protease inhibitor and one of the key regulators of tumor invasion and metastasis. The purpose of this study was to elucidate the effect of PAI-1 gene transfection on liver metastasis and its mechanism by using the human high liver metastasis pancreatic cancer cell line, SW 1990. PAI-1-transfected SW1990 (SW/PAI-1) produced a significantly higher level of PAI-1 in supernatant than parental cells. While no difference was observed for the production of u-PA and u-PA activity in the supernatant, cell proliferation of SW/PAI-1 was slightly suppressed on the 7th day of incubation compared to parental cells. Cellular invasion, in vivo tumorigenesis in xenograft and liver metastasis were significantly suppressed in SW/PAI-1 cells compared to parental cells. The angiogenesis of xenograft by detecting microvascular density and the production of metastasis-related factors, such as VEGF and TGF-B1, were also decreased in SW/PAI-1 cells. These findings suggested that PAI-1 gene transfection might have the ability to prevent the liver metastasis of pancreatic cancer by modulating angiogenesis.

    PubMed

  • 5-Fluorouracil up-regulates interferon pathway gene expression in esophageal cancer cells. Reviewed

    Matsumura Y, Yashiro M, Ohira M, Tabuchi H, Hirakawa K

    Anticancer research   25 ( 5 )   3271 - 8   2005.09( ISSN:0250-7005

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  • Serrated adenomas have a pattern of genetic alterations that distinguishes them from other colorectal polyps Reviewed

    Yashiro M, Laghi L, Saito K, Carethers JM, Slezak P, Rubio C, Hirakawa K, Boland CR

    CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION   14 ( 9 )   2253 - 2256   2005.09( ISSN:1055-9965

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    DOI: 10.1158/1055-9965.EPI-04-0790

    PubMed

  • 5-fluorouracil up-regulates interferon pathway gene expression in esophageal cancer cells Reviewed

    Y Matsumura, M Yashiro, M Ohira, H Tabuch, K Hirakawa

    ANTICANCER RESEARCH   25 ( 5 )   3271 - 3278   2005.09( ISSN:0250-7005

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    5-Fluorouracil (FU) is a chemotherapeutic agent commonly used against esophageal cancer. Recently, interferons (IFNs) have been administered together with cytotoxic chemotherapy to patients with this cancer, although the mechanisms of synergy are unknown. We reconsidered the mechanisms for the effects of 5-FU in this context, aiming to refine combination therapy. After three cell lines (T.T, TE-2, and TE-6), derived from human esophageal squamous cell carcinoma (SCC), were exposed to 5-FU, the expression profiles were analyzed using high-density oligonucleotide microarrays representing about 12,000 genes. Among them, three IFN-related genes, an IFN receptor gene (IFNAR2) and two IFN-stimulated genes (ISG15K, ISG-54K), that were up-regulated following addition of 5-FU, were investigated. Upregulation was confirmed by RT-PCR. Based on these results, the antitumor effects of exposure to 5-FU simultaneously with IFN-alpha, -beta and -gamma were investigated. The growth of esophageal SCC cells with 5-FU was suppressed synergistically or semi-additively by IFN-alpha and -beta, but not by IFN-gamma. These findings indicated that 5-FU stimulated IFN pathways in esophageal SCC cells following tip-regulation of the IFN type I receptor. A combination of 5-FU and an IFN, therefore, may be particularly efficacious in esophageal cancer.

    PubMed

  • 5-Fluorouracil up-regulates interferon pathway gene expression in esophageal cancer cells. Reviewed

    Matsumura Y, Yashiro M, Ohira M, Tabuchi H, Hirakawa K

    Anticancer research   25 ( 5 )   3271 - 8   2005.09( ISSN:0250-7005

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    PubMed

  • Serrated adenomas have a pattern of genetic alterations that distinguishes them from other colorectal polyps Reviewed

    M Yashiro, L Laghi, K Saito, JM Carethers, P Slezak, C Rubio, K Hirakawa, CR Boland

    CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION   14 ( 9 )   2253 - 2256   2005.09( ISSN:1055-9965

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    Background: Serrated adenomas are characterized by serrated crypts with dysplasia, and are distinguished from other polyps by their histology, but the genetic basis of serrated adenomas is unknown. We investigated genetic alterations in colorectal polyps to determine if a specific pattern were associated with serrated adenomas.
    Methods: Sixty-six small (&lt; 10 mm) colorectal polyps were studied, including 11 hyperplastic polyps, 27 serrated adenomas, 9 tubular adenomas, 6 tubulovillous adenomas, and 3 villous adenomas. Allelic imbalance and microsatellite instability were detected by analysis of microsatellites on 5q, 18q, 17p, 2p, and 3p; K-ras mutations were detected by oligonucleotide hybridization.
    Results: Each polyp subset had its own characteristic mutational signature. Allelic imbalance of 18q was significantly more common (P &lt; 0.05), whereas allelic imbalance of 5q and K-ras mutations were significantly less common (P &lt; 0.05) in serrated adenomas compared with other polyps. Allelic imbalance of 17p was not found in any polyp.
    Conclusions: Serrated adenomas are significantly more likely to have allelic imbalance at 18q than other types of adenomas, and significantly less likely to have allelic imbalance at 5q or K-ras mutations. Serrated adenomas seem to evolve through a different genetic pathway than other types of polyps in the colon.

    DOI: 10.1158/1055-9965.EPI-04-0790

    PubMed

  • 緊急手術におけるストーマ造設法と合併症対策 Reviewed

    前田 清, 松田 常美, 西原 承浩, 田中 結華, 井上 透, 八代 正和, 野田 英児, 高垣 敬一, 山田 靖哉, 西口 幸雄, 平川 弘聖

    日本大腸肛門病学会雑誌   58 ( 9 )   549 - 549   2005.09( ISSN:0047-1801 ( eISSN:1882-9619

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  • Up regulation of ICAM-1 gene expression inhibits tumour growth and liver metastasis in colorectal carcinoma Reviewed

    Tachimori A, Yamada N, Sakate Y, Yashiro M, Maeda K, Ohira M, Nishino H, Hirakawa K

    EUROPEAN JOURNAL OF CANCER   41 ( 12 )   1802 - 1810   2005.08( ISSN:0959-8049

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    DOI: 10.1016/j.ejca.2005.04.036

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  • Up regulation of ICAM-1 gene expression inhibits tumour growth and liver metastasis in colorectal carcinoma Reviewed

    A Tachimori, N Yamada, Y Sakate, M Yashiro, K Maeda, M Ohira, H Nishino, K Hirakawa

    EUROPEAN JOURNAL OF CANCER   41 ( 12 )   1802 - 10   2005.08( ISSN:0959-8049

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    We have previously reported that decreased intercellular adhesion molecule-1 (ICAM-1) expression in cancer cells is associated with liver metastasis of colorectal cancer. In this study, we have investigated the effect of ICAM-1 gene transfection into the human colorectal cancer cell line LM-H3 on cell adhesiveness and cytotoxicity of peripheral blood mononuclear cells (PBMC) to cancer cells. Furthermore, we have investigated the effects of this gene transfer on subcutaneous tumour and liver metastases of LM-H3 in nude mice. More PBMC adhered to ICAM-1 transfected LM-H3 cells, LM-H3/ICAM-1, than to non-transfected LM-H3 cells and control LM-H3/Vector. Lysis of LM-H3/ICAM-1 cells by PBMC was significantly increased compared with LM-H3/Vector. Liver metastases with LM-H3/ICAM-1 cells were fewer in number and smaller than metastases with LM-H3/Vector. Intra-tumoural injection of ICAM-1 adenoviral vector significantly inhibited the growth of subcutaneous LM-H3 tumour. In conclusion ICAM-1 gene transfection using adenovirus vector might be an effective therapy for liver metastasis of colorectal carcinoma. (C) 2005 Elsevier Ltd. All rights reserved.

    DOI: 10.1016/j.ejca.2005.04.036

    PubMed

  • DNAマイクロアレイによるスキルス胃癌の遺伝子発現解析とK-samII阻害剤による分子標的治療(胃・十二指腸25, 第60回日本消化器外科学会総会) Reviewed

    八代 正和, 中村 和憲, 井上 透, 山田 靖哉, 小野田 尚佳, 前田 清, 澤田 鉄二, 大平 雅一, 三輪 篤史, 平川 弘聖

    一般社団法人日本消化器外科学会 日本消化器外科学会雑誌   38 ( 7 )   2005.07( ISSN:03869768

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  • Fibroblast growth factor receptor2 (FGFR2) 阻害剤Ki23057による胆道癌の分子標的治療(肝・胆・膵32, 第60回日本消化器外科学会総会) Reviewed

    天野 良亮, 山田 靖哉, 八代 正和, 日月 亜紀子, 中村 和憲, 大平 雅一, 三輪 篤史, 西野 裕二, 平川 弘聖

    一般社団法人日本消化器外科学会 日本消化器外科学会雑誌   38 ( 7 )   2005.07( ISSN:03869768

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  • Plasminogen activator inhibitor-1 (PAI-1) 遺伝子導入による膵癌細胞の肝転移抑制効果(第60回日本消化器外科学会定期学術総会) Reviewed

    井上 雅文, 澤田 鉄二, 内間 恭武, 島本 里絵, 西原 承浩, 山田 靖哉, 山下 好人, 八代 正和, 大平 雅一, 平川 弘聖

    一般社団法人日本消化器外科学会 日本消化器外科学会雑誌   38 ( 7 )   2005.07( ISSN:03869768

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    CiNii Article

  • K-samII阻害剤によるスキルス胃癌リンパ節転移に対する分子標的治療(食道・胃・十二指腸6, 第60回日本消化器外科学会総会) Reviewed

    中村 和憲, 八代 正和, 天道 正成, 山田 靖哉, 澤田 鉄二, 大平 雅一, 西口 幸雄, 加藤 保之, 三輪 篤史, 平川 弘聖

    一般社団法人日本消化器外科学会 日本消化器外科学会雑誌   38 ( 7 )   2005.07( ISSN:03869768

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  • 切除不能大腸悪性狭窄における治療戦略 : ステント留置術vs人工肛門造設術(小腸3, 第60回日本消化器外科学会総会) Reviewed

    前田 清, 井上 透, 八代 正和, 西原 承浩, 野田 英児, 山田 靖哉, 山下 好人, 六車 一哉, 西口 幸雄, 平川 弘聖

    一般社団法人日本消化器外科学会 日本消化器外科学会雑誌   38 ( 7 )   2005.07( ISSN:03869768

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  • 遺伝子メチル化からみた残胃癌の特異性(胃・十二指腸25, 第60回日本消化器外科学会総会) Reviewed

    小野田 尚佳, 巳野 綾, 藤原 一郎, 久保 尚士, 綾 誠, 八代 正和, 山田 靖哉, 大平 雅一, 石川 哲郎, 平川 弘聖

    一般社団法人日本消化器外科学会 日本消化器外科学会雑誌   38 ( 7 )   2005.07( ISSN:03869768

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  • 超音波内視鏡下FNAを応用した胃GISTの診断および治療戦略(GIST-診断と治療の問題点, 第60回日本消化器外科学会総会) Reviewed

    六車 一哉, 澤田 鉄二, 木村 健二郎, 井上 透, 西原 承浩, 八代 正和, 山下 好人, 山田 靖哉, 大平 雅一, 平川 弘聖

    一般社団法人日本消化器外科学会 日本消化器外科学会雑誌   38 ( 7 )   2005.07( ISSN:03869768

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  • 線維芽細胞を target としたスキルス胃癌の治療(食道・胃・十二指腸29, 第60回日本消化器外科学会総会) Reviewed

    天道 正成, 八代 正和, 中澤 一憲, 井上 透, 山田 靖哉, 澤田 鉄二, 西口 幸雄, 大平 雅一, 加藤 保之, 平川 弘聖

    一般社団法人日本消化器外科学会 日本消化器外科学会雑誌   38 ( 7 )   2005.07( ISSN:03869768

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  • 潰瘍性大腸炎緊急手術例に対する hand-assisted surgery(第60回日本消化器外科学会定期学術総会) Reviewed

    井上 透, 前田 清, 八代 正和, 西原 承浩, 高島 勉, 山田 靖哉, 山下 好人, 西口 幸雄, 大平 雅一, 平川 弘聖

    一般社団法人日本消化器外科学会 日本消化器外科学会雑誌   38 ( 7 )   2005.07( ISSN:03869768

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  • 消化器外科におけるクリニカルパスを導入した術後感染症に対する周術期管理について(全般9, 第60回日本消化器外科学会総会) Reviewed

    西原 承浩, 前田 清, 八代 正和, 山下 好人, 山田 靖哉, 小野田 尚佳, 澤田 鉄二, 大平 雅一, 石川 哲郎, 平川 弘聖

    一般社団法人日本消化器外科学会 日本消化器外科学会雑誌   38 ( 7 )   2005.07( ISSN:03869768

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  • 残胃癌におけるp16遺伝子メチル化についての検討(胃・十二指腸25, 第60回日本消化器外科学会総会) Reviewed

    己野 綾, 小野田 尚佳, 藤原 一郎, 久保 尚志, 綾 誠, 八代 正和, 山田 靖哉, 大平 雅一, 石川 哲郎, 平川 弘聖

    一般社団法人日本消化器外科学会 日本消化器外科学会雑誌   38 ( 7 )   2005.07( ISSN:03869768

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  • 成人鼠径ヘルニアに対する局所麻酔下手術の工夫(全般9, 第60回日本消化器外科学会総会) Reviewed

    金原 功, 澤田 鉄二, 細野 俊介, 八代 正和, 山下 好人, 六車 一哉, 西原 承浩, 山田 靖哉, 大平 雅一, 平川 弘聖

    一般社団法人日本消化器外科学会 日本消化器外科学会雑誌   38 ( 7 )   2005.07( ISSN:03869768

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  • 大腸癌肝転移に対する5-FU肝動注+CPT-11静注併用療法の第I相臨床試験(大腸18, 第60回日本消化器外科学会総会) Reviewed

    山田 靖哉, 天道 正茂, 八代 正和, 山下 好人, 前田 清, 澤田 鉄二, 大平 雅一, 石川 哲郎, 西野 裕二, 平川 弘聖

    一般社団法人日本消化器外科学会 日本消化器外科学会雑誌   38 ( 7 )   2005.07( ISSN:03869768

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  • DNAマイクロアレイによるスキルス胃癌の遺伝子発現解析とK-samII阻害剤による分子標的治療(胃・十二指腸25, 第60回日本消化器外科学会総会) Reviewed

    八代 正和, 中村 和憲, 井上 透, 山田 靖哉, 小野田 尚佳, 前田 清, 澤田 鉄二, 大平 雅一, 三輪 篤史, 平川 弘聖

    日本消化器外科学会雑誌   38 ( 7 )   1083   2005.07( ISSN:03869768

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  • K-samII阻害剤によるスキルス胃癌リンパ節転移に対する分子標的治療(食道・胃・十二指腸6, 第60回日本消化器外科学会総会) Reviewed

    中村 和憲, 八代 正和, 天道 正成, 山田 靖哉, 澤田 鉄二, 大平 雅一, 西口 幸雄, 加藤 保之, 三輪 篤史, 平川 弘聖

    日本消化器外科学会雑誌   38 ( 7 )   1161   2005.07( ISSN:03869768

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  • Fibroblast growth factor receptor2 (FGFR2) 阻害剤Ki23057による胆道癌の分子標的治療(肝・胆・膵32, 第60回日本消化器外科学会総会) Reviewed

    天野 良亮, 山田 靖哉, 八代 正和, 日月 亜紀子, 中村 和憲, 大平 雅一, 三輪 篤史, 西野 裕二, 平川 弘聖

    日本消化器外科学会雑誌   38 ( 7 )   1204   2005.07( ISSN:03869768

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  • Plasminogen activator inhibitor-1 (PAI-1) 遺伝子導入による膵癌細胞の肝転移抑制効果(第60回日本消化器外科学会定期学術総会) Reviewed

    井上 雅文, 澤田 鉄二, 内間 恭武, 島本 里絵, 西原 承浩, 山田 靖哉, 山下 好人, 八代 正和, 大平 雅一, 平川 弘聖

    日本消化器外科学会雑誌   38 ( 7 )   1127   2005.07( ISSN:03869768

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  • 切除不能大腸悪性狭窄における治療戦略 : ステント留置術vs人工肛門造設術(小腸3, 第60回日本消化器外科学会総会) Reviewed

    前田 清, 井上 透, 八代 正和, 西原 承浩, 野田 英児, 山田 靖哉, 山下 好人, 六車 一哉, 西口 幸雄, 平川 弘聖

    日本消化器外科学会雑誌   38 ( 7 )   1072   2005.07( ISSN:03869768

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  • 遺伝子メチル化からみた残胃癌の特異性(胃・十二指腸25, 第60回日本消化器外科学会総会) Reviewed

    小野田 尚佳, 巳野 綾, 藤原 一郎, 久保 尚士, 綾 誠, 八代 正和, 山田 靖哉, 大平 雅一, 石川 哲郎, 平川 弘聖

    日本消化器外科学会雑誌   38 ( 7 )   1083   2005.07( ISSN:03869768

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  • 超音波内視鏡下FNAを応用した胃GISTの診断および治療戦略(GIST-診断と治療の問題点, 第60回日本消化器外科学会総会) Reviewed

    六車 一哉, 澤田 鉄二, 木村 健二郎, 井上 透, 西原 承浩, 八代 正和, 山下 好人, 山田 靖哉, 大平 雅一, 平川 弘聖

    日本消化器外科学会雑誌   38 ( 7 )   984   2005.07( ISSN:03869768

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  • 線維芽細胞を target としたスキルス胃癌の治療(食道・胃・十二指腸29, 第60回日本消化器外科学会総会) Reviewed

    天道 正成, 八代 正和, 中澤 一憲, 井上 透, 山田 靖哉, 澤田 鉄二, 西口 幸雄, 大平 雅一, 加藤 保之, 平川 弘聖

    日本消化器外科学会雑誌   38 ( 7 )   1218   2005.07( ISSN:03869768

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  • 潰瘍性大腸炎緊急手術例に対する hand-assisted surgery(第60回日本消化器外科学会定期学術総会) Reviewed

    井上 透, 前田 清, 八代 正和, 西原 承浩, 高島 勉, 山田 靖哉, 山下 好人, 西口 幸雄, 大平 雅一, 平川 弘聖

    日本消化器外科学会雑誌   38 ( 7 )   1100   2005.07( ISSN:03869768

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  • 消化器外科におけるクリニカルパスを導入した術後感染症に対する周術期管理について(全般9, 第60回日本消化器外科学会総会) Reviewed

    西原 承浩, 前田 清, 八代 正和, 山下 好人, 山田 靖哉, 小野田 尚佳, 澤田 鉄二, 大平 雅一, 石川 哲郎, 平川 弘聖

    日本消化器外科学会雑誌   38 ( 7 )   1090   2005.07( ISSN:03869768

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  • 残胃癌におけるp16遺伝子メチル化についての検討(胃・十二指腸25, 第60回日本消化器外科学会総会) Reviewed

    己野 綾, 小野田 尚佳, 藤原 一郎, 久保 尚志, 綾 誠, 八代 正和, 山田 靖哉, 大平 雅一, 石川 哲郎, 平川 弘聖

    日本消化器外科学会雑誌   38 ( 7 )   1083   2005.07( ISSN:03869768

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  • 成人鼠径ヘルニアに対する局所麻酔下手術の工夫(全般9, 第60回日本消化器外科学会総会) Reviewed

    金原 功, 澤田 鉄二, 細野 俊介, 八代 正和, 山下 好人, 六車 一哉, 西原 承浩, 山田 靖哉, 大平 雅一, 平川 弘聖

    日本消化器外科学会雑誌   38 ( 7 )   1192   2005.07( ISSN:03869768

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  • 大腸癌肝転移に対する5-FU肝動注+CPT-11静注併用療法の第I相臨床試験(大腸18, 第60回日本消化器外科学会総会) Reviewed

    山田 靖哉, 天道 正茂, 八代 正和, 山下 好人, 前田 清, 澤田 鉄二, 大平 雅一, 石川 哲郎, 西野 裕二, 平川 弘聖

    日本消化器外科学会雑誌   38 ( 7 )   1039   2005.07( ISSN:03869768

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  • Inhibitory effect of a selective cyclooxygenase inhibitor on the invasion-stimulating activity of orthotopic fibroblasts for scirrhous gastric cancer cells Reviewed

    Tendo M, Yashiro M, Nakazawa K, Yamada N, Hirakawa K

    CANCER SCIENCE   96 ( 7 )   451 - 455   2005.07( ISSN:1347-9032

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    DOI: 10.1111/j.1349-7006.2005.00066.x

    PubMed

  • Inhibitory effect of a selective cyclooxygenase inhibitor on the invasion-stimulating activity of orthotopic fibroblasts for scirrhous gastric cancer cells Reviewed

    M Tendo, M Yashiro, K Nakazawa, N Yamada, K Hirakawa

    CANCER SCIENCE   96 ( 7 )   451 - 5   2005.07( ISSN:1347-9032

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    The cyclooxygenase (COX)-2 inhibitor has been reported to impede the progression of gastric cancer, but underlying mechanisms remain unclear. We therefore investigated the effect of a COX-2 inhibitor, JTE-522, on the ability of orthotopic fibroblasts to stimulate invasion of scirrhous gastric carcinoma cells. The human scirrhous gastric cancer cell lines OCUM-2D or OCUM-2M, and human gastric fibroblasts (NF-21) were cultured in the absence or presence of JTE-522 at various concentrations. Cancer cells were then assayed for invasiveness in vitro by invasion assay. The effect of prostaglandins (PG) on growth factor production in NF-21 cells was examined by ELISA. Finally, the effects of orally administrated JTE-522 on orthotopically transplanted tumors were examined in nude mice. NF-21 cells stimulated invasion by OCUM-2D cells, an effect suppressed by JTE-522 at 5 x 10(-6) M. Hepatocyte growth factor (HGF) and PGE2 production by NF-21 cells were suppressed by JTE-522 (P &lt; 0.01). PGE2 stimulated HGF production by NF-21 cells in a dose-dependent manner. JTE-522 significantly suppressed orthotopic tumor growth and lymph node metastasis, and also decreased HGF expression by fibroblasts within the gastric tumor. in conclusion, we found that gastric fibroblasts stimulated invasiveness in scirrhous gastric cancer cells, whereas a selective COX-2 inhibitor inhibited this paracrine effect by decreasing fibroblast PGE2 production, resulting in downregulation of HGF production.

    DOI: 10.1111/j.1349-7006.2005.00066.x

    PubMed

  • ICAM-1遺伝子治療の大腸癌肝転移における可能性(第105回日本外科学会定期学術集会) Reviewed

    日月 亜紀子, 山田 靖哉, 坂手 洋二, 山下 好人, 八代 正和, 前田 清, 小野田 尚佳, 西口 幸雄, 大平 雅一, 石川 哲郎, 加藤 保之, 西野 裕二, 平川 弘聖

    一般社団法人日本外科学会 日本外科学会雑誌   106 ( 0 )   2005.04( ISSN:03014894

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  • スキルス胃癌細胞の増殖進展における微小環境と keratinocyte growth factor の関与(第105回日本外科学会定期学術集会) Reviewed

    八代 正和, 中澤 一憲, 松岡 翼, 井上 透, 天道 正成, 安田 晃一, 仲田 文造, 山田 靖哉, 前田 清, 小野田 尚佳, 澤田 鉄二, 西口 幸雄, 大平 雅一, 石川 哲郎, 加藤 保之, 平川 弘聖

    一般社団法人日本外科学会 日本外科学会雑誌   106 ( 0 )   2005.04( ISSN:03014894

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  • 食道癌に対する Pan-erbB tyrosine kinase inhibitor CI1033を用いた分子標的治療(第105回日本外科学会定期学術集会) Reviewed

    阿古 英次, 山下 好人, 大平 雅一, 山崎 政直, 井上 透, 西原 承浩, 八代 正和, 山田 靖哉, 小野田 尚佳, 前田 清, 澤田 鉄二, 西口 幸雄, 石川 哲郎, 加藤 保之, 平川 弘聖

    一般社団法人日本外科学会 日本外科学会雑誌   106 ( 0 )   2005.04( ISSN:03014894

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  • 術中腹腔洗浄細胞診陽性胃癌に対するTS-1を用いた adjuvant Chemotherapy の効果について(第105回日本外科学会定期学術集会) Reviewed

    六車 一哉, 澤田 鉄二, 阿古 英次, 山下 好人, 八代 正和, 山田 靖哉, 前田 清, 仲田 文造, 西口 幸雄, 大平 雅一, 平川 弘聖

    一般社団法人日本外科学会 日本外科学会雑誌   106 ( 0 )   2005.04( ISSN:03014894

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  • 胸部食道T1b癌に対する治療戦略 : 手術か化学放射線療法 (CRT) か(第105回日本外科学会定期学術集会) Reviewed

    大平 雅一, 山下 好人, 久保 尚士, 阿古 英次, 六車 一哉, 井上 透, 西原 承浩, 山田 靖哉, 八代 正和, 前田 清, 澤田 鉄二, 西口 幸雄, 加藤 保之, 平川 弘聖

    一般社団法人日本外科学会 日本外科学会雑誌   106 ( 0 )   2005.04( ISSN:03014894

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  • 線維芽細胞の相互作用から見たCOX-2 inhibitor のスキルス胃癌抑制効果(第105回日本外科学会定期学術集会) Reviewed

    天道 正成, 八代 正和, 中澤 一憲, 高島 勉, 井上 透, 西原 承浩, 山下 好人, 山田 靖哉, 前田 清, 澤田 鉄二, 仲田 文造, 大平 雅一, 西口 幸雄, 加藤 保之, 平川 弘聖

    一般社団法人日本外科学会 日本外科学会雑誌   106 ( 0 )   2005.04( ISSN:03014894

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  • 残胃癌におけるp16遺伝子メチル化についての検討(第105回日本外科学会定期学術集会) Reviewed

    己野 綾, 小野田 尚佳, 藤原 一郎, 久保 尚士, 綾 誠, 八代 正和, 西原 承造, 山下 好人, 山田 靖哉, 西口 幸雄, 加藤 保之, 前田 清, 澤田 鉄二, 大平 雅一, 仲田 文造, 石川 哲郎, 平川 弘聖

    一般社団法人日本外科学会 日本外科学会雑誌   106 ( 0 )   2005.04( ISSN:03014894

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    CiNii Article

  • チロシンキナーゼ型KGF-receptor の阻害による4型胃癌の分子標的治療(第105回日本外科学会定期学術集会) Reviewed

    中村 和憲, 八代 正和, 天道 正成, 山田 靖哉, 澤田 鉄二, 小野田 尚佳, 大平 雅一, 前田 清, 仲田 文造, 三輪 篤史, 平川 弘聖

    一般社団法人日本外科学会 日本外科学会雑誌   106 ( 0 )   2005.04( ISSN:03014894

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  • ICAM-1遺伝子治療の大腸癌肝転移における可能性(第105回日本外科学会定期学術集会) Reviewed

    日月 亜紀子, 山田 靖哉, 坂手 洋二, 山下 好人, 八代 正和, 前田 清, 小野田 尚佳, 西口 幸雄, 大平 雅一, 石川 哲郎, 加藤 保之, 西野 裕二, 平川 弘聖

    日本外科学会雑誌   106 ( 0 )   416   2005.04( ISSN:03014894

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  • スキルス胃癌細胞の増殖進展における微小環境と keratinocyte growth factor の関与(第105回日本外科学会定期学術集会) Reviewed

    八代 正和, 中澤 一憲, 松岡 翼, 井上 透, 天道 正成, 安田 晃一, 仲田 文造, 山田 靖哉, 前田 清, 小野田 尚佳, 澤田 鉄二, 西口 幸雄, 大平 雅一, 石川 哲郎, 加藤 保之, 平川 弘聖

    日本外科学会雑誌   106 ( 0 )   256   2005.04( ISSN:03014894

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  • チロシンキナーゼ型KGF-receptor の阻害による4型胃癌の分子標的治療(第105回日本外科学会定期学術集会) Reviewed

    中村 和憲, 八代 正和, 天道 正成, 山田 靖哉, 澤田 鉄二, 小野田 尚佳, 大平 雅一, 前田 清, 仲田 文造, 三輪 篤史, 平川 弘聖

    日本外科学会雑誌   106 ( 0 )   509   2005.04( ISSN:03014894

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    CiNii Article

  • 残胃癌におけるp16遺伝子メチル化についての検討(第105回日本外科学会定期学術集会) Reviewed

    己野 綾, 小野田 尚佳, 藤原 一郎, 久保 尚士, 綾 誠, 八代 正和, 西原 承造, 山下 好人, 山田 靖哉, 西口 幸雄, 加藤 保之, 前田 清, 澤田 鉄二, 大平 雅一, 仲田 文造, 石川 哲郎, 平川 弘聖

    日本外科学会雑誌   106 ( 0 )   248   2005.04( ISSN:03014894

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  • 食道癌に対する Pan-erbB tyrosine kinase inhibitor CI1033を用いた分子標的治療(第105回日本外科学会定期学術集会) Reviewed

    阿古 英次, 山下 好人, 大平 雅一, 山崎 政直, 井上 透, 西原 承浩, 八代 正和, 山田 靖哉, 小野田 尚佳, 前田 清, 澤田 鉄二, 西口 幸雄, 石川 哲郎, 加藤 保之, 平川 弘聖

    日本外科学会雑誌   106 ( 0 )   442   2005.04( ISSN:03014894

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  • 術中腹腔洗浄細胞診陽性胃癌に対するTS-1を用いた adjuvant Chemotherapy の効果について(第105回日本外科学会定期学術集会) Reviewed

    六車 一哉, 澤田 鉄二, 阿古 英次, 山下 好人, 八代 正和, 山田 靖哉, 前田 清, 仲田 文造, 西口 幸雄, 大平 雅一, 平川 弘聖

    日本外科学会雑誌   106 ( 0 )   511   2005.04( ISSN:03014894

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  • 胸部食道T1b癌に対する治療戦略 : 手術か化学放射線療法 (CRT) か(第105回日本外科学会定期学術集会) Reviewed

    大平 雅一, 山下 好人, 久保 尚士, 阿古 英次, 六車 一哉, 井上 透, 西原 承浩, 山田 靖哉, 八代 正和, 前田 清, 澤田 鉄二, 西口 幸雄, 加藤 保之, 平川 弘聖

    日本外科学会雑誌   106 ( 0 )   189   2005.04( ISSN:03014894

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  • 線維芽細胞の相互作用から見たCOX-2 inhibitor のスキルス胃癌抑制効果(第105回日本外科学会定期学術集会) Reviewed

    天道 正成, 八代 正和, 中澤 一憲, 高島 勉, 井上 透, 西原 承浩, 山下 好人, 山田 靖哉, 前田 清, 澤田 鉄二, 仲田 文造, 大平 雅一, 西口 幸雄, 加藤 保之, 平川 弘聖

    日本外科学会雑誌   106 ( 0 )   508   2005.04( ISSN:03014894

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  • Effect of organ-specific fibroblasts on proliferation and differentiation of breast cancer cells Reviewed

    Yashiro M, Ikeda K, Tendo M, Ishikawa T, Hirakawa K

    BREAST CANCER RESEARCH AND TREATMENT   90 ( 3 )   307 - 313   2005.04( ISSN:0167-6806

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    DOI: 10.1007/s10549-004-5364-z

    PubMed

  • Effect of organ-specific fibroblasts on proliferation and differentiation of breast cancer cells Reviewed

    M Yashiro, K Ikeda, M Tendo, T Ishikawa, K Hirakawa

    BREAST CANCER RESEARCH AND TREATMENT   90 ( 3 )   307 - 13   2005.04( ISSN:0167-6806

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    Breast carcinomas contain both tumor cells and stromal cells, including fibroblasts, endothelial cells, and lymphocytes. Proliferation of breast cancer cells may be controlled partly by mesenchymal cells, especially fibroblasts. We studied effects of fibroblasts on tumorigenicity and histologic features of breast cancer cells vivo, and analyzed fibroblast-produced growth-promoting factors in vitro. Breast carcinoma cells from four lines, and fibroblasts from lines obtained from skin and breast tissue of four patients with breast cancer were used. A suitable number of breast tumor cells and fibroblasts were inoculated subcutaneously into nude mice; resulting tumors were examined. Then conditioned medium from fibroblasts was added to cultures of breast cancer cells to study growth effects, and growth-promoting factors from breast fibroblasts were analyzed. Co-inoculation of breast cancer cells with breast fibroblasts into mice significantly increased tumorigenicity and tumor size beyond those obtained with breast cancer cells alone. Histologically, tumors resulting from co-inoculation with breast fibroblasts showed a scirrhous pattern with extensive fibrosis, while those formed by breast cancer cells injected alone or co-inoculation with skin fibroblasts showed a solid pattern. Medium from breast fibroblasts significantly increased breast cancer cell growth in vitro, while the various skin fibroblasts did not all show this effect. Structural and functional interactions between organ-specific fibroblasts and breast cancer cells may importantly regulate breast cancer growth and progression.

    DOI: 10.1007/s10549-004-5364-z

    PubMed

  • Usefulness of a Metallic Stent Placement for Obstructive Colorectal Cancer Reviewed

    MAEDA Kiyoshi, INOUE Toru, NISHIHARA Tamahiro, YASHIRO Masakazu, NODA Eiji, NISHIGUCHI Yukio, HIRAKAWA Kosei

    25 ( 3 )   513 - 515   2005.03( ISSN:13402242

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  • Frequent microsatellite instability in primary esophageal carcinoma associated with extraesophageal primary carcinoma Reviewed

    Kubo N, Yashiro M, Ohira M, Hori T, Fujiwara I, Hirakawa K

    INTERNATIONAL JOURNAL OF CANCER   114 ( 2 )   166 - 173   2005.03( ISSN:0020-7136

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    DOI: 10.1002/ijc.20725

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  • Frequent microsatellite instability in primary esophageal carcinoma associated with extraesophageal primary carcinoma Reviewed

    N Kubo, M Yashiro, M Ohira, T Hori, Fujiwara, I, K Hirakawa

    INTERNATIONAL JOURNAL OF CANCER   114 ( 2 )   166 - 73   2005.03( ISSN:0020-7136

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    Patients with esophageal squamous cell carcinoma (ESCC) frequently develop other primary cancers, such as gastric cancer and head and neck cancer. Details of carcinogenesis in patients with multiple primaries that include esophageal carcinoma with other primary carcinoma (ECOPC) remain uncertain. We examined microsatellite instability (MSI) status, frameshift mutation in target genes of MSI, mismatch repair protein expression and hypermethylation of the hMLH1 promoter region in ECOPC patients to better understand the underlying carcinogenic processes. High frequency MSI (NISI-H) was found in 15 (44.1%) of 34 patients with ECOPC, but in only 6 (14.3%) of 42 patients with esophageal cancer alone (p &lt; 0.01). Frameshift mutations in TGFbetaRII, BAX, MSH3 and MSH6 genes respectively were present in 4, 1, 2 and 2 of 34 ECOPC patients. Immunohistochemical study showed that 12 (80.0%) of 15 MISI-H tumors showed loss of expression of either hMLH1 or hMSH2. In addition, 6 of 9 tumors (66.7%) that showed reduced hMLH1 expression also had hypermethylation of the hMLH1 promoter region. Our findings suggested that carcinogenesis in ECOPC was closely associated with the MSI pathway because of mismatch repair protein deficiency. (C) 2004 Wiley-Liss, Inc.

    DOI: 10.1002/ijc.20725

    PubMed

  • A novel high-specificity approach for colorectal neoplasia: Detection of K-ras2 oncogene mutation in normal mucosa Reviewed

    Yamada S, Yashiro M, Maeda K, Nishiguchi Y, Hirakawa K

    INTERNATIONAL JOURNAL OF CANCER   113 ( 6 )   1015 - 1021   2005.03( ISSN:0020-7136

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    DOI: 10.1002/ijc.20666

    PubMed

  • A novel high-specificity approach for colorectal neoplasia: Detection of K-ras2 oncogene mutation in normal mucosa Reviewed

    S Yamada, M Yashiro, K Maeda, Y Nishiguchi, K Hirakawa

    INTERNATIONAL JOURNAL OF CANCER   113 ( 6 )   1015 - 21   2005.03( ISSN:0020-7136

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    There is an important need for a high-specificity approach to colorectal cancer. Approximately 50% of colorectal tumors contain K-ras gene mutations, which occur as an early step in carcinogenesis. K-ras mutations were detectable not only in tumors but also in microscopically normal colorectal mucosa close to carcinomas in some patients with colorectal cancer. This is the first systematic analysis of K-ras mutations in normal colonic mucosa at multiple consistently-selected locations. A total of 480 normal colonic mucosal samples were obtained from 80 subjects, including 65 patients with sporadic colorectal cancer and 15 controls in whom a colorectal neoplasm was ruled out endoscopically. Normal mucosal samples were obtained at multiple consistently-selected locations using biopsy forceps during colonoscopy. Mutant allele-specific amplification (MASA)-PCR was performed; this could detect a K-ras mutation in normal colonic mucosa even though it was only sparsely present. The K-ras mutation was found in histologically normal mucosa from colorectal cancer patients (20 of 65 cases; 41 of 390 loci) by MASA-PCR, especially frequent (51%; 19 of 37 cases) when the tumor showed a K-ras mutation. In contrast, no mutation was found in normal mucosa from 15 controls (90 loci). K-ras mutation in normal mucosa showed a significant association with the presence of colorectal cancer (p = 0.008). The specificity of the MASA-PCR method for colorectal neoplasms was thus 100%. We conclude that detection of K-ras mutations in normal colonic mucosa might serve as a high-specificity approach to colorectal cancer. (C) 2004 Wiley-Liss, Inc.

    DOI: 10.1002/ijc.20666

    PubMed

  • K-ras mutation influences macroscopic features of gastric carcinoma Reviewed

    Yashiro M, Nishioka N, Hirakawa K

    JOURNAL OF SURGICAL RESEARCH   124 ( 1 )   74 - 78   2005.03( ISSN:0022-4804

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    DOI: 10.1016/j.jss.2004.09.020

    PubMed

  • K-ras mutation influences macroscopic features of gastric carcinoma Reviewed

    M Yashiro, N Nishioka, K Hirakawa

    JOURNAL OF SURGICAL RESEARCH   124 ( 1 )   74 - 8   2005.03( ISSN:0022-4804

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    Introduction. Gastric carcinoma is classified morphologically as type 1 to 4. Type 1 is defined as a polypoid tumor; types 2 and 3 are defined as ulcerated tumors with polypoid growth or gastric wall infiltration, respectively, and type 4 tumors are defined as flat. This morphological classification is important because biological characteristics differ between the four morphological types, but little is known about genetic differences between them.
    Materials and methods. One hundred eight gastric tumors were classified macroscopically as type 1 to 4. Tumoral DNA was microdissected from paraffin-embedded tissue sections. PCR amplification of exon 1 of a K-ras containing codons 12 and 13 was performed. K-ras amplicons were dot-blotted onto nylon filters and hybridized with radiolabeled oligomer primers.
    Results. A K-ras mutation was found in 20 of 108 gastric cancers. A significant relationship of K-ras mutation with polypoid cancer was found. The frequency of K-ras mutation was 6/14 (43%), 8/29 (28%), 2/11 (18%), and 4/54 (7%) in type 1 to 4 tumors, respectively. K-ras mutation was correlated with well-differentiated tumors. Of various types of K-ras mutations, 12 Asp often was seen in type 1 and 2 gastric cancers (well-demarcated, elevated tumors), while 12 Val and 12 Ser were often seen in type 3 and 4 cases (infiltrating carcinomas).
    Conclusion. K-ras mutations occur prominently in type 1 and type 2 gastric cancers. (c) 2004 Elsevier Inc. All rights reserved.

    DOI: 10.1016/j.jss.2004.09.020

    PubMed

  • 5-fluorouracil up-regulates interferon pathway gene expression in esophageal cancer cells Reviewed

    Matsumura Y, Yashiro M, Ohira M, Tabuch H, Hirakawa K

    ANTICANCER RESEARCH   25 ( 5 )   3271 - 3278   2005( ISSN:0250-7005

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  • Anti tumor effect of pan-erbB tyrosine kinase inhibitor CI-1033 on human esophageal cancer cell growth Reviewed

    A. E., Y. Y., O. M., Y. M., N. K., Y. M., H. K.

    Japanese Society for Molecular Tumor Marker Research, Japan Journal of Molecular Tumor Marker Research   ( 20 )   48 - 48   2005

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    DOI: 10.11241/jsmtmr.20.48

    CiNii Article

  • The treatment of the scirrhous gastric carcinoma the molecule target marker of which was K-sam II Reviewed

    N. K., Y. M., T. M., Y. N., Y. Y., S. T., O. M., M. A., H. K.

    Japanese Society for Molecular Tumor Marker Research, Japan Journal of Molecular Tumor Marker Research   ( 20 )   49 - 49   2005

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    DOI: 10.11241/jsmtmr.20.49

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  • SELF EXPANDABLE METALLIC STENT FOR COLORECTAL OBSTRUCTION CAUSED BY PERITONEAL DISSEMINATION OF GASTRIC CANCER Reviewed

    UCHIMA Yasutake, HIRAKAWA Kosei, MAEDA Kiyoshi, HORI Takeshi, OSAWA Naoshi, HORIE Hideki, INOUE Toru, NISHIHARA Tamahiro, YASHIRO Masakazu, SAWADA Tetsuji

    Japan Gastroenterological Endoscopy Society, GASTROENTEROLOGICAL ENDOSCOPY   47 ( 8 )   1548 - 1553   2005( ISSN:0387-1207

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    Disseminated intra-abdominal malignancies of recurrent or advanced gastric cancer can also cause colonic or rectal obstruction by extrinsic compression. Surgical treatment is usual option to treat malignant bowel obstruction. However, this usually involved emergency surgery on poor-risk and clinically unstable patients with unprepared bowels. In many cases, particu-larly in palliative surgery, the creation of colostomy is inevitable. The self-expandable metallic stent (SEMS) has been found to be effective in relieving colorectal obstruction, both as a palliative treatment for unresectable tumor and as a temporary measure for subsequent surgery. We reported our preliminary experience with the use of endoscopic self-spandable Ultraflex stents as a palliative treatment for colorectal obstruction for peritoneal dissemina-tion of gastric cancer. All SEMS of five patients with colorectal obstruction were enplaced successfully and covered the obstructive lesions satisfactorily. Bowel function returned within 24 hours, and per oral feeding began again after a day. Four patients of them died of the disease 1 to 14 months after placement of SEMS. The complication of other one was dislocation of SEMS, because of progressive response of recurrence gastric cancer with peritoneal dissemina-tion after chemotherapy of S-1. No one complained of abdominal discomfort and incontinence of stool. The use of SEMS can achieve rapid and effective non-surgical means to relieve colorectal obstruction. It provided good palliation for unresectable peritoneal dissemination of gastric cancer that causes colorectal obstruction.

    DOI: 10.11280/gee1973b.47.1548

    CiNii Article

  • Usefulness of a Metallic Stent Placement for Obstructive Colorectal Cancer Reviewed

    Maeda Kiyoshi, Inoue Toru, Nishihara Tamahiro, Yashiro Masakazu, Noda Eiji, Nishiguchi Yukio, Hirakawa Kosei

    Japanese Society for Abdominal Emergency Medicine, Nihon Fukubu Kyukyu Igakkai Zasshi (Journal of Abdominal Emergency Medicine)   25 ( 3 )   513 - 515   2005( ISSN:1340-2242

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    The treatment of colorectal obstruction caused by colorectal cancer usually requires emergency surgery. Recently several alternative treatments for colorectal obstruction have been reported, including transanal insertion of a drainage tube, and metallic stent placement. These treatments can avoid emergency surgery and allow surgery in elective conditions. Moreover, for patients with an unresectable colorectal obstruction, the creation of a permanent stoma is usually inevitable. However, in such cases, we have attempted to place a metallic stent, and we have achieved adequate decompression without the creation of a stoma. In conclusion, placement of a metallic stent is a feasible and effective adjunct and an alternative to a stoma in cases of malignant large bowel obstruction. This treatment may be less invasive compared with the creation of a stoma, and provides an improvement in the quality of life for patients with colorectal obstructions.

    DOI: 10.11231/jaem1993.25.513

    CiNii Article

  • The treatment of the scirrhous gastric carcinoma the molecule target marker of which was K-sam II Reviewed

    N. K., Y. M., T. M., Y. N., Y. Y., S. T., O. M., M. A., H. K.

    Japan Journal of Molecular Tumor Marker Research   20   49 - 49   2005( eISSN:24338575

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.11241/jsmtmr.20.49

    CiNii Article

  • SELF EXPANDABLE METALLIC STENT FOR COLORECTAL OBSTRUCTION CAUSED BY PERITONEAL DISSEMINATION OF GASTRIC CANCER Reviewed

    UCHIMA Yasutake, MAEDA Kiyoshi, HORI Takeshi, OSAWA Naoshi, HORIE Hideki, INOUE Toru, NISHIHARA Tamahiro, YASHIRO Masakazu, SAWADA Tetsuji, HIRAKAWA Kosei

    GASTROENTEROLOGICAL ENDOSCOPY   47 ( 8 )   1548 - 1553   2005( ISSN:03871207 ( eISSN:18845738

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    Publishing type:Research paper (scientific journal)  

    Disseminated intra-abdominal malignancies of recurrent or advanced gastric cancer can also cause colonic or rectal obstruction by extrinsic compression. Surgical treatment is usual option to treat malignant bowel obstruction. However, this usually involved emergency surgery on poor-risk and clinically unstable patients with unprepared bowels. In many cases, particu-larly in palliative surgery, the creation of colostomy is inevitable. The self-expandable metallic stent (SEMS) has been found to be effective in relieving colorectal obstruction, both as a palliative treatment for unresectable tumor and as a temporary measure for subsequent surgery. We reported our preliminary experience with the use of endoscopic self-spandable Ultraflex stents as a palliative treatment for colorectal obstruction for peritoneal dissemina-tion of gastric cancer. All SEMS of five patients with colorectal obstruction were enplaced successfully and covered the obstructive lesions satisfactorily. Bowel function returned within 24 hours, and per oral feeding began again after a day. Four patients of them died of the disease 1 to 14 months after placement of SEMS. The complication of other one was dislocation of SEMS, because of progressive response of recurrence gastric cancer with peritoneal dissemina-tion after chemotherapy of S-1. No one complained of abdominal discomfort and incontinence of stool. The use of SEMS can achieve rapid and effective non-surgical means to relieve colorectal obstruction. It provided good palliation for unresectable peritoneal dissemination of gastric cancer that causes colorectal obstruction.

    DOI: 10.11280/gee1973b.47.1548

    CiNii Article

  • Anti tumor effect of pan-erbB tyrosine kinase inhibitor CI-1033 on human esophageal cancer cell growth Reviewed

    A. E., Y. Y., O. M., Y. M., N. K., Y. M., H. K.

    Japan Journal of Molecular Tumor Marker Research   20   48 - 48   2005

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.11241/jsmtmr.20.48

    CiNii Article

  • Usefulness of a Metallic Stent Placement for Obstructive Colorectal Cancer Reviewed

    Maeda Kiyoshi, Inoue Toru, Nishihara Tamahiro, Yashiro Masakazu, Noda Eiji, Nishiguchi Yukio, Hirakawa Kosei

    Nihon Fukubu Kyukyu Igakkai Zasshi (Journal of Abdominal Emergency Medicine)   25 ( 3 )   513 - 515   2005( ISSN:13402242 ( eISSN:18824781

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    Publishing type:Research paper (scientific journal)  

    The treatment of colorectal obstruction caused by colorectal cancer usually requires emergency surgery. Recently several alternative treatments for colorectal obstruction have been reported, including transanal insertion of a drainage tube, and metallic stent placement. These treatments can avoid emergency surgery and allow surgery in elective conditions. Moreover, for patients with an unresectable colorectal obstruction, the creation of a permanent stoma is usually inevitable. However, in such cases, we have attempted to place a metallic stent, and we have achieved adequate decompression without the creation of a stoma. In conclusion, placement of a metallic stent is a feasible and effective adjunct and an alternative to a stoma in cases of malignant large bowel obstruction. This treatment may be less invasive compared with the creation of a stoma, and provides an improvement in the quality of life for patients with colorectal obstructions.

    DOI: 10.11231/jaem1993.25.513

    CiNii Article

  • ICAM-2 gene therapy for peritoneal dissemination of scirrhous gastric carcinoma.

    Clin Cancer Res.   10   4885   2004

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  • Is a lymph node detected by the dye-guided method a true sentinel node in gastric cancer?

    Clin Cancer Res   10   6912   2004

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  • An opposing view on WWOX protein function as a tumor suppressor.

    Cancer Res   63   8629   2003

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  • Keratinocyte growth factor produced by gastric fibroblasts specifically stimulates proliferation of cancer cells from scirrhous gastric carcinoma.

    Cancer Res   63   8848   2003

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  • Prognostic value of microsatellite instability in resectable pancreatic cancer.

    8   2536   2002

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    Publishing type:Research paper (scientific journal)   Kind of work:Single Work  

  • Genetic pathways in the evolution of morphologically distinct colorectal neoplasms.

    Cancer Res   61   2676   2001

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  • Differential gene expression profiles of scirrhous gastric cancer cells with high metastatic potential to peritoneum or lymph nodes.

    Hippo Y, Yashiro M

    Cancer Res.   61 ( 889 )   895   2001

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Books and Other Publications

  • Fungi from different environments

    Misra J. K., Deshmukh S. K. (Sunil Kumar)( Role: Sole author)

    Science Publishers  2009  ( ISBN:9781578085781

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    Book type:Scholarly book

    CiNii Books

  • Fungi from different environments

    Misra J. K., Deshmukh S. K. (Sunil Kumar)( Role: Sole author)

    Science Publishers  2009  ( ISBN:9781578085781

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    Book type:Scholarly book

    CiNii Books

  • Synchronous multiple primary gastrointestinal cancer exhibits frequent microsatellite instability.

    ( Role: Joint author)

    2000 

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    Responsible for pages:678  

MISC

  • C-CAT's triumph in gastroenterology: the wisdom of cats is infinitely superior(タイトル和訳中) Reviewed

    Enomoto Masaru, Odagiri Naoshi, Rinka Koji, Maruyama Hirotsugu, Shimamoto Yoshinori, Ishikawa-Kakiya Yuki, Fujiwara Yasuhiro, Kawada Norifumi, Yashiro Masakazu

    Journal of Gastroenterology   59 ( 2 )   157 - 158   2024.02( ISSN:0944-1174

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    Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 【免疫療法を支える基礎研究】腫瘍免疫に影響を及ぼす大腸癌関連線維芽細胞亜集団の機能と役割 Reviewed

    笠島 裕明, 福井 康裕, 北山 紀州, 三木 友一朗, 吉井 真美, 福岡 達成, 田村 達郎, 渋谷 雅常, 豊川 貴弘, 李 栄柱, 田中 浩明, 八代 正和, 前田 清

    癌と化学療法   50 ( 9 )   958 - 959   2023.09( ISSN:0385-0684

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    癌関連線維芽細胞(cancer-associated fibroblasts:CAFs)は腫瘍微小環境を構成する主要な細胞の一つであり,様々な機序を介して腫瘍の進展や転移,さらには抗癌剤耐性に関与すると報告されている。さらに近年,CAFと腫瘍免疫微小環境(tumor immune-microenvironment:TIME)の相互作用が腫瘍進展にかかわる重要な因子であることが明らかとなっており,その機序の解明が癌免疫療法の治療戦略に大きく影響すると考えられている。われわれは,single-cell RNA sequencing解析を用いて大腸癌におけるCAFが免疫細胞との相互作用を介し,腫瘍免疫を制御することにより腫瘍進展に関与していることを報告したことから,近年報告されている腫瘍免疫にかかわる文献を加えて総説する。(著者抄録)

  • 癌関連線維芽細胞亜集団の不均一性 その起源、バイオマーカー、腫瘍微小環境における役割(The heterogeneity of cancer-associated fibroblast subpopulations: Their origins, biomarkers, and roles in the tumor microenvironment) Reviewed

    Yamamoto Yurie, Kasashima Hiroaki, Fukui Yasuhiro, Tsujio Gen, Yashiro Masakazu, Maeda Kiyoshi

    Cancer Science   114 ( 1 )   16 - 24   2023.01( ISSN:1347-9032

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  • Exosomes of ST3G5<sup>high</sup> cancer cells promote pre-metastatic niche of peritoneal dissemination Reviewed

    田中正光, 堀江美里, 高金くらら, 伊藤剛, 栗山正, 柳原五吉, 八代正和

    日本癌学会学術総会抄録集(Web)   82nd   2023

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    J-GLOBAL

  • 【ゲノムからロボットまでこれ一冊でわかる!最新の胃癌診療】胃癌の分子生物学 Reviewed

    八代 正和, 辻尾 元, 松岡 翼

    消化器外科   45 ( 6 )   627 - 634   2022.06( ISSN:0387-2645

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  • がん遺伝子パネル検査を用いたクリニカルシーケンスの課題と現状 Reviewed

    西村 貞徳, 杉本 敦史, 櫛山 周平, 栂野 真吾, 黒田 顕慈, 山内 真, 角 俊幸, 金田 裕靖, 川口 知哉, 加藤 実, 木村 健二郎, 永原 央, 六車 一哉, 李 栄柱, 高島 勉, 久保 正二, 大平 雅一, 八代 正和

    日本分子腫瘍マーカー研究会誌   36   5 - 6   2021( eISSN:2433-8575

  • 【スキルス胃癌のすべて】基礎 スキルス胃癌腹膜播種形成の分子機構と分子標的治療 Reviewed

    八代 正和, 大平 雅一

    (株)南江堂 外科   81 ( 1 )   12 - 15   2019.01( ISSN:0016-593X

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    <文献概要>スキルス胃癌は高頻度に腹膜に転移する.転移形式は癌細胞が原発巣から腹腔内に遊離し,腹膜に接着,浸潤増殖する播種性の転移が主である.スキルス胃癌の腹膜転移には,細胞間接着分子の発現低下,癌周囲微小環境の線維芽細胞や低酸素,TGFβ,CXCL1,FGF7,HGFなどの増殖因子が関与する.スキルス胃癌に特化した分子標的治療薬はないが,増殖浸潤機序に基づいたシグナル阻害薬や線維芽細胞抑制薬などの有望な分子標的阻害薬が開発中である.

  • 【スキルス胃癌のすべて】基礎 スキルス胃癌腹膜播種形成の分子機構と分子標的治療 Reviewed

    八代 正和, 大平 雅一

    外科   81 ( 1 )   12 - 15   2019.01( ISSN:0016-593X

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    <文献概要>スキルス胃癌は高頻度に腹膜に転移する.転移形式は癌細胞が原発巣から腹腔内に遊離し,腹膜に接着,浸潤増殖する播種性の転移が主である.スキルス胃癌の腹膜転移には,細胞間接着分子の発現低下,癌周囲微小環境の線維芽細胞や低酸素,TGFβ,CXCL1,FGF7,HGFなどの増殖因子が関与する.スキルス胃癌に特化した分子標的治療薬はないが,増殖浸潤機序に基づいたシグナル阻害薬や線維芽細胞抑制薬などの有望な分子標的阻害薬が開発中である.

  • スキルス胃癌細胞系の意義 細胞系とマウスモデルを用いた分子特性分析(The significance of scirrhous gastric cancer cell lines: the molecular characterization using cell lines and mouse models) Reviewed

    Yashiro Masakazu, Matsuoka Tasuku, Ohira Masaichi

    日本ヒト細胞学会 Human Cell   31 ( 4 )   271 - 281   2018.10( ISSN:0914-7470

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  • スキルス胃癌細胞系の意義 細胞系とマウスモデルを用いた分子特性分析(The significance of scirrhous gastric cancer cell lines: the molecular characterization using cell lines and mouse models) Reviewed

    Yashiro Masakazu, Matsuoka Tasuku, Ohira Masaichi

    Human Cell   31 ( 4 )   271 - 281   2018.10( ISSN:0914-7470

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  • 切除可能胸部食道癌における治療前予後因子としての炎症・栄養マーカーの比較検討 Reviewed

    豊川 貴弘, 田村 達郎, 櫻井 克宣, 天野 良亮, 久保 尚士, 田中 浩明, 六車 一哉, 八代 正和, 平川 弘聖, 大平 雅一

    日本外科代謝栄養学会, 外科と代謝・栄養   52 ( 3 )   116 - 116   2018.06( ISSN:0389-5564

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  • 審査腹腔鏡にて診断し得た食道胃接合部癌術後遅発性乳糜腹水の1例 Reviewed

    高橋 諒, 田村 達郎, 田内 潤, 豊川 貴弘, 久保 尚士, 田中 浩明, 六車 一哉, 八代 正和, 平川 弘聖, 大平 雅一

    (NPO)日本食道学会, 日本食道学会学術集会プログラム・抄録集   72回   208 - 208   2018.06

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  • 胸部食道癌手術における術前栄養状態と術後合併症の関連 Reviewed

    杉本 敦史, 田村 達郎, 櫻井 克宣, 豊川 貴弘, 久保 尚士, 崎村 千恵, 田内 潤, 福岡 達成, 大平 豪, 渋谷 雅常, 山添 定明, 永原 央, 木村 健二郎, 天野 良亮, 田中 浩明, 六車 一哉, 八代 正和, 前田 清, 平川 弘聖, 大平 雅一

    日本外科代謝栄養学会, 外科と代謝・栄養   52 ( 3 )   145 - 145   2018.06( ISSN:0389-5564

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  • 高齢早期胃癌患者における予後影響因子とスコア化 Reviewed

    櫻井 克宣, 久保 尚士, 玉森 豊, 西居 孝文, 日月 亜紀子, 井上 透, 田村 達郎, 豊川 貴弘, 田中 浩明, 六車 一哉, 八代 正和, 前田 清, 西口 幸雄, 大平 雅一

    日本外科代謝栄養学会, 外科と代謝・栄養   52 ( 3 )   133 - 133   2018.06( ISSN:0389-5564

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  • 食道癌術前補助化学療法の治療効果と免疫栄養との関連 Reviewed

    田村 達郎, 豊川 貴弘, 櫻井 克宜, 久保 尚士, 天野 良亮, 田中 浩明, 六車 一哉, 八代 正和, 平川 弘聖, 大平 雅一

    (NPO)日本食道学会, 日本食道学会学術集会プログラム・抄録集   72回   311 - 311   2018.06

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  • 食道癌術前化学療法の治療効果予測におけるNLRの有用性 Reviewed

    田村 達郎, 櫻井 克宣, 豊川 貴弘, 久保 尚士, 福岡 達成, 大平 豪, 渋谷 雅常, 山添 定明, 永原 央, 木村 健二郎, 天野 良亮, 田中 浩明, 六車 一哉, 八代 正和, 前田 清, 平川 弘聖, 大平 雅一

    日本外科代謝栄養学会, 外科と代謝・栄養   52 ( 3 )   143 - 143   2018.06( ISSN:0389-5564

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  • 食道癌手術における食道胃管吻合縫合不全の危険因子の解析 Reviewed

    杉本 敦史, 田村 達郎, 豊川 貴弘, 櫻井 克宣, 久保 尚士, 田中 浩明, 六車 一哉, 八代 正和, 平川 弘聖, 大平 雅一

    (NPO)日本食道学会, 日本食道学会学術集会プログラム・抄録集   72回   213 - 213   2018.06

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  • 血行遮断先行左反回神経周囲リンパ節郭清手技 Reviewed

    豊川 貴弘, 田村 達郎, 久保 尚士, 櫻井 克宜, 天野 良亮, 田中 浩明, 六車 一哉, 八代 正和, 平川 弘聖, 大平 雅一

    (NPO)日本食道学会, 日本食道学会学術集会プログラム・抄録集   72回   351 - 351   2018.06

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  • 切除可能胸部食道癌における治療前予後因子としての炎症・栄養マーカーの比較検討

    豊川 貴弘, 田村 達郎, 櫻井 克宣, 天野 良亮, 久保 尚士, 田中 浩明, 六車 一哉, 八代 正和, 平川 弘聖, 大平 雅一

    外科と代謝・栄養   52 ( 3 )   116 - 116   2018.06( ISSN:0389-5564

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  • 審査腹腔鏡にて診断し得た食道胃接合部癌術後遅発性乳糜腹水の1例

    高橋 諒, 田村 達郎, 田内 潤, 豊川 貴弘, 久保 尚士, 田中 浩明, 六車 一哉, 八代 正和, 平川 弘聖, 大平 雅一

    日本食道学会学術集会プログラム・抄録集   72回   208 - 208   2018.06

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  • 胸部食道癌手術における術前栄養状態と術後合併症の関連

    杉本 敦史, 田村 達郎, 櫻井 克宣, 豊川 貴弘, 久保 尚士, 崎村 千恵, 田内 潤, 福岡 達成, 大平 豪, 渋谷 雅常, 山添 定明, 永原 央, 木村 健二郎, 天野 良亮, 田中 浩明, 六車 一哉, 八代 正和, 前田 清, 平川 弘聖, 大平 雅一

    外科と代謝・栄養   52 ( 3 )   145 - 145   2018.06( ISSN:0389-5564

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  • 高齢早期胃癌患者における予後影響因子とスコア化

    櫻井 克宣, 久保 尚士, 玉森 豊, 西居 孝文, 日月 亜紀子, 井上 透, 田村 達郎, 豊川 貴弘, 田中 浩明, 六車 一哉, 八代 正和, 前田 清, 西口 幸雄, 大平 雅一

    外科と代謝・栄養   52 ( 3 )   133 - 133   2018.06( ISSN:0389-5564

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  • 食道癌術前補助化学療法の治療効果と免疫栄養との関連

    田村 達郎, 豊川 貴弘, 櫻井 克宜, 久保 尚士, 天野 良亮, 田中 浩明, 六車 一哉, 八代 正和, 平川 弘聖, 大平 雅一

    日本食道学会学術集会プログラム・抄録集   72回   311 - 311   2018.06

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  • 食道癌術前化学療法の治療効果予測におけるNLRの有用性

    田村 達郎, 櫻井 克宣, 豊川 貴弘, 久保 尚士, 福岡 達成, 大平 豪, 渋谷 雅常, 山添 定明, 永原 央, 木村 健二郎, 天野 良亮, 田中 浩明, 六車 一哉, 八代 正和, 前田 清, 平川 弘聖, 大平 雅一

    外科と代謝・栄養   52 ( 3 )   143 - 143   2018.06( ISSN:0389-5564

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  • 食道癌手術における食道胃管吻合縫合不全の危険因子の解析

    杉本 敦史, 田村 達郎, 豊川 貴弘, 櫻井 克宣, 久保 尚士, 田中 浩明, 六車 一哉, 八代 正和, 平川 弘聖, 大平 雅一

    日本食道学会学術集会プログラム・抄録集   72回   213 - 213   2018.06

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  • 血行遮断先行左反回神経周囲リンパ節郭清手技

    豊川 貴弘, 田村 達郎, 久保 尚士, 櫻井 克宜, 天野 良亮, 田中 浩明, 六車 一哉, 八代 正和, 平川 弘聖, 大平 雅一

    日本食道学会学術集会プログラム・抄録集   72回   351 - 351   2018.06

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  • 癌関連線維芽細胞が悪性黒色腫細胞の進展に与える影響についての検討

    藤川平四朗, 八代正和, 羽多野隆治, 前田周作, 出口綾香, 上野真理恵, 元村尚嗣

    日本皮膚悪性腫瘍学会学術大会プログラム・抄録集   34th   122   2018.06

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    J-GLOBAL

  • 【外科医のがん研究】胃外科医としてスキルス胃がん研究 Reviewed

    八代 正和

    (一社)日本外科学会 日本外科学会雑誌   119 ( 3 )   266 - 271   2018.05( ISSN:0301-4894

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    およそ30年間にわたり消化器外科にたずさわり、また同時に研究も行ってきた。胃がんは最も多く臨床経験した疾患である。大学院生時代に経験したスキルス胃がん症例からがん細胞株や線維芽細胞株を樹立した。それらの細胞株を用いてスキルス胃がん研究を始め、結果的に25年間研究を行い、スキルス胃がんの病態について新しい発見があった。その研究成果をもとに、現在スキルス胃がんの治療法開発にも関わっている。日頃の臨床診療で感じていた疑問をベンチで明らかにしその結果をベッドサイドに還元する研究活動は、外科医としてのモチベーション持続の源になる。外科医はトランスレーショナルリサーチに好位置にあり、研究における外科医の優位性を生かし、臨床経験で生じた疑問を研究で解明するresearch mindを持ち続けてほしい。(著者抄録)

  • ここまで進化した縦郭鏡下/胸腔鏡下食道切除術 左反回神経周囲リンパ節郭清の安定化 Reviewed

    豊川 貴弘, 田村 達郎, 櫻井 克宣, 天野 良亮, 久保 尚士, 田中 浩明, 六車 一哉, 八代 正和, 平川 弘聖, 大平 雅一

    日本外科系連合学会, 日本外科系連合学会誌   43 ( 3 )   425 - 425   2018.05( ISSN:0385-7883

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  • 【外科医のがん研究】 胃外科医としてスキルス胃がん研究 Reviewed

    八代 正和

    (一社)日本外科学会, 日本外科学会雑誌   119 ( 3 )   266 - 271   2018.05( ISSN:0301-4894

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    およそ30年間にわたり消化器外科にたずさわり、また同時に研究も行ってきた。胃がんは最も多く臨床経験した疾患である。大学院生時代に経験したスキルス胃がん症例からがん細胞株や線維芽細胞株を樹立した。それらの細胞株を用いてスキルス胃がん研究を始め、結果的に25年間研究を行い、スキルス胃がんの病態について新しい発見があった。その研究成果をもとに、現在スキルス胃がんの治療法開発にも関わっている。日頃の臨床診療で感じていた疑問をベンチで明らかにしその結果をベッドサイドに還元する研究活動は、外科医としてのモチベーション持続の源になる。外科医はトランスレーショナルリサーチに好位置にあり、研究における外科医の優位性を生かし、臨床経験で生じた疑問を研究で解明するresearch mindを持ち続けてほしい。(著者抄録)

  • ここまで進化した縦郭鏡下/胸腔鏡下食道切除術 左反回神経周囲リンパ節郭清の安定化

    豊川 貴弘, 田村 達郎, 櫻井 克宣, 天野 良亮, 久保 尚士, 田中 浩明, 六車 一哉, 八代 正和, 平川 弘聖, 大平 雅一

    日本外科系連合学会誌   43 ( 3 )   425 - 425   2018.05( ISSN:0385-7883

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  • 【外科医のがん研究】胃外科医としてスキルス胃がん研究 Reviewed

    八代 正和

    日本外科学会雑誌   119 ( 3 )   266 - 271   2018.05( ISSN:0301-4894

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    およそ30年間にわたり消化器外科にたずさわり、また同時に研究も行ってきた。胃がんは最も多く臨床経験した疾患である。大学院生時代に経験したスキルス胃がん症例からがん細胞株や線維芽細胞株を樹立した。それらの細胞株を用いてスキルス胃がん研究を始め、結果的に25年間研究を行い、スキルス胃がんの病態について新しい発見があった。その研究成果をもとに、現在スキルス胃がんの治療法開発にも関わっている。日頃の臨床診療で感じていた疑問をベンチで明らかにしその結果をベッドサイドに還元する研究活動は、外科医としてのモチベーション持続の源になる。外科医はトランスレーショナルリサーチに好位置にあり、研究における外科医の優位性を生かし、臨床経験で生じた疑問を研究で解明するresearch mindを持ち続けてほしい。(著者抄録)

  • 【外科医のがん研究】 胃外科医としてスキルス胃がん研究

    八代 正和

    日本外科学会雑誌   119 ( 3 )   266 - 271   2018.05( ISSN:0301-4894

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    およそ30年間にわたり消化器外科にたずさわり、また同時に研究も行ってきた。胃がんは最も多く臨床経験した疾患である。大学院生時代に経験したスキルス胃がん症例からがん細胞株や線維芽細胞株を樹立した。それらの細胞株を用いてスキルス胃がん研究を始め、結果的に25年間研究を行い、スキルス胃がんの病態について新しい発見があった。その研究成果をもとに、現在スキルス胃がんの治療法開発にも関わっている。日頃の臨床診療で感じていた疑問をベンチで明らかにしその結果をベッドサイドに還元する研究活動は、外科医としてのモチベーション持続の源になる。外科医はトランスレーショナルリサーチに好位置にあり、研究における外科医の優位性を生かし、臨床経験で生じた疑問を研究で解明するresearch mindを持ち続けてほしい。(著者抄録)

  • Stage III胃癌における炎症・栄養指標の予後因子としての意義 Reviewed

    豊川 貴弘, 六車 一哉, 田村 達郎, 福岡 達成, 大平 豪, 渋谷 雅常, 櫻井 克宣, 山添 定明, 木村 健二郎, 永原 央, 天野 良亮, 久保 尚士, 玉森 豊, 田中 浩明, 八代 正和, 前田 清, 平川 弘聖, 大平 雅一

    (一財)日本消化器病学会, 日本消化器病学会雑誌   115 ( 臨増総会 )   A269 - A269   2018.04( ISSN:0446-6586

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  • スキルス胃癌由来エキソソームが腹膜微小環境におよぼす影響 Reviewed

    奥野 倫久, 八代 正和, 三木 友一朗, 黒田 顕慈, 栂野 真吾, 笠島 裕明, 中前 博久, 中根 孝彦, 日野 雅之, 平川 弘聖, 大平 雅一

    (一社)日本外科学会, 日本外科学会定期学術集会抄録集   118回   1299 - 1299   2018.04

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  • スキルス胃癌における癌関連線維芽細胞由来CD9陽性エクソソームの意義 Reviewed

    三木 友一朗, 八代 正和, 奥野 倫久, 黒田 顕慈, 栂野 真吾, 田村 達郎, 櫻井 克宣, 豊川 貴弘, 久保 尚士, 木村 健二郎, 天野 良亮, 田中 浩明, 六車 一哉, 平川 弘聖, 大平 雅一

    (一社)日本外科学会, 日本外科学会定期学術集会抄録集   118回   2267 - 2267   2018.04

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  • 上部消化管癌周術期における予後規定因子 Stage II/III胃癌における予後予測因子としての炎症・栄養指標の意義 Reviewed

    豊川 貴弘, 六車 一哉, 田村 達郎, 福岡 達成, 大平 豪, 渋谷 雅常, 櫻井 克宜, 山添 定明, 木村 健二郎, 永原 央, 天野 良亮, 田中 浩明, 久保 尚士, 八代 正和, 前田 清, 平川 弘聖, 大平 雅一

    (一社)日本外科学会, 日本外科学会定期学術集会抄録集   118回   666 - 666   2018.04

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  • 胃癌における胃漿膜捺印細胞診による術後再発予測および再発予防に関する臨床試験 Reviewed

    三木 友一朗, 八代 正和, 奥野 倫久, 北山 紀州, 田村 達郎, 豊川 貴弘, 田中 浩明, 六車 一哉, 平川 弘聖, 大平 雅一

    (一財)日本消化器病学会, 日本消化器病学会雑誌   115 ( 臨増総会 )   A253 - A253   2018.04( ISSN:0446-6586

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  • 結腸癌治癒切除後予後予測因子としての原発病変部位 Reviewed

    永原 央, 前田 清, 渋谷 雅常, 福岡 達成, 中尾 重富, 松谷 慎治, 田村 達郎, 大平 豪, 山添 定明, 木村 健二郎, 豊川 貴弘, 天野 良亮, 田中 浩明, 六車 一哉, 八代 正和, 平川 弘聖, 大平 雅一

    (一社)日本外科学会, 日本外科学会定期学術集会抄録集   118回   2239 - 2239   2018.04

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  • 当科における肥満症例に対する腹腔鏡下大腸切除術の治療成績の検討 Reviewed

    辻尾 元, 福岡 達成, 前田 清, 永原 央, 澁谷 雅常, 中尾 重富, 松谷 慎治, 田村 達郎, 大平 豪, 山添 定明, 木村 健二郎, 豊川 貴弘, 天野 良亮, 田中 浩明, 六車 一哉, 八代 正和, 平川 弘聖, 大平 雅一

    (一社)日本外科学会, 日本外科学会定期学術集会抄録集   118回   1518 - 1518   2018.04

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  • 局所進行膵癌に対する肝動脈合併膵切除術の治療成績 Reviewed

    天野 良亮, 木村 健二郎, 山添 定明, 大平 豪, 福岡 達成, 田村 達郎, 渋谷 雅常, 永原 央, 豊川 貴弘, 田中 浩明, 六車 一哉, 八代 正和, 前田 清, 平川 弘聖, 大平 雅一

    (一社)日本外科学会, 日本外科学会定期学術集会抄録集   118回   2418 - 2418   2018.04

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  • 胃癌患者におけるCEA陽性血中循環腫瘍細胞(CTC)同定及びその臨床的意義 Reviewed

    黒田 顕慈, 八代 正和, 三木 友一朗, 奥野 倫久, 栂野 真吾, 田村 達郎, 櫻井 克宜, 豊川 貴弘, 久保 尚士, 木村 健二郎, 田中 浩明, 六車 一哉, 平川 弘聖, 大平 雅一

    (一社)日本外科学会, 日本外科学会定期学術集会抄録集   118回   954 - 954   2018.04

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  • 高齢者直腸癌患者における腹腔鏡手術の検討 Reviewed

    福岡 達成, 前田 清, 永原 央, 渋谷 雅常, 中尾 重富, 松谷 慎治, 田村 達郎, 大平 豪, 山添 定明, 木村 健二郎, 豊川 貴弘, 天野 良亮, 田中 浩明, 六車 一哉, 八代 正和, 平川 弘聖, 大平 雅一

    (一社)日本外科学会, 日本外科学会定期学術集会抄録集   118回   1547 - 1547   2018.04

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  • 食道癌患者における筋肉量減少率と臨床病理学的因子の関連 Reviewed

    田村 達郎, 櫻井 克宣, 豊川 貴弘, 天野 良亮, 久保 尚士, 田中 浩明, 六車 一哉, 八代 正和, 前田 清, 平川 弘聖, 大平 雅一

    (一社)日本外科学会, 日本外科学会定期学術集会抄録集   118回   2332 - 2332   2018.04

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  • 門脈浸潤陽性遠位胆管癌に関する検討 Reviewed

    山添 定明, 天野 良亮, 木村 健二郎, 大平 豪, 田内 潤, 田中 涼太, 福岡 達成, 田村 達郎, 渋谷 雅常, 永原 央, 豊川 貴弘, 田中 浩明, 六車 一哉, 八代 正和, 前田 清, 平川 弘聖, 大平 雅一

    (一社)日本外科学会, 日本外科学会定期学術集会抄録集   118回   2409 - 2409   2018.04

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  • 進行胃癌に対する漿膜捺印細胞診および擦過細胞RT-PCR法による胃癌術後再発予測 Reviewed

    栂野 真吾, 八代 正和, 三木 友一朗, 奥野 倫久, 黒田 顕慈, 田村 達郎, 櫻井 克宣, 豊川 貴弘, 久保 尚士, 木村 健二郎, 天野 良亮, 田中 浩明, 六車 一哉, 平川 弘聖, 大平 雅一

    (一社)日本外科学会, 日本外科学会定期学術集会抄録集   118回   1293 - 1293   2018.04

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  • 腹腔鏡下脾臓温存膵体尾部切除術後の脾静脈閉塞例の検討 Reviewed

    木村 健二郎, 天野 良亮, 山添 定明, 大平 豪, 田内 潤, 田中 涼太, 福岡 達成, 田村 達郎, 永原 央, 豊川 貴弘, 田中 浩明, 六車 一哉, 前田 清, 八代 正和, 平川 弘聖, 大平 雅一

    (一社)日本外科学会, 日本外科学会定期学術集会抄録集   118回   1717 - 1717   2018.04

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  • 腫瘍炎症環境において間質に依存する胃癌進展の分子メカニズム Reviewed

    石本 崇胤, 三宅 慧輔, 八代 正和, 内原 智幸, 有馬 浩太, 泉 大輔, 岩槻 政晃, 馬場 祥史, 渡邊 雅之, Tan Patrick, 馬場 秀夫

    (一社)日本外科学会, 日本外科学会定期学術集会抄録集   118回   961 - 961   2018.04

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  • Stage III胃癌における炎症・栄養指標の予後因子としての意義

    豊川 貴弘, 六車 一哉, 田村 達郎, 福岡 達成, 大平 豪, 渋谷 雅常, 櫻井 克宣, 山添 定明, 木村 健二郎, 永原 央, 天野 良亮, 久保 尚士, 玉森 豊, 田中 浩明, 八代 正和, 前田 清, 平川 弘聖, 大平 雅一

    日本消化器病学会雑誌   115 ( 臨増総会 )   A269 - A269   2018.04( ISSN:0446-6586

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  • 高齢者直腸癌患者における腹腔鏡手術の検討

    福岡 達成, 前田 清, 永原 央, 渋谷 雅常, 中尾 重富, 松谷 慎治, 田村 達郎, 大平 豪, 山添 定明, 木村 健二郎, 豊川 貴弘, 天野 良亮, 田中 浩明, 六車 一哉, 八代 正和, 平川 弘聖, 大平 雅一

    日本外科学会定期学術集会抄録集   118回   1547 - 1547   2018.04

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  • スキルス胃癌における癌関連線維芽細胞由来CD9陽性エクソソームの意義

    三木 友一朗, 八代 正和, 奥野 倫久, 黒田 顕慈, 栂野 真吾, 田村 達郎, 櫻井 克宣, 豊川 貴弘, 久保 尚士, 木村 健二郎, 天野 良亮, 田中 浩明, 六車 一哉, 平川 弘聖, 大平 雅一

    日本外科学会定期学術集会抄録集   118回   2267 - 2267   2018.04

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    Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 結腸癌治癒切除後予後予測因子としての原発病変部位

    永原 央, 前田 清, 渋谷 雅常, 福岡 達成, 中尾 重富, 松谷 慎治, 田村 達郎, 大平 豪, 山添 定明, 木村 健二郎, 豊川 貴弘, 天野 良亮, 田中 浩明, 六車 一哉, 八代 正和, 平川 弘聖, 大平 雅一

    日本外科学会定期学術集会抄録集   118回   2239 - 2239   2018.04

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  • 当科における肥満症例に対する腹腔鏡下大腸切除術の治療成績の検討

    辻尾 元, 福岡 達成, 前田 清, 永原 央, 澁谷 雅常, 中尾 重富, 松谷 慎治, 田村 達郎, 大平 豪, 山添 定明, 木村 健二郎, 豊川 貴弘, 天野 良亮, 田中 浩明, 六車 一哉, 八代 正和, 平川 弘聖, 大平 雅一

    日本外科学会定期学術集会抄録集   118回   1518 - 1518   2018.04

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  • 局所進行膵癌に対する肝動脈合併膵切除術の治療成績

    天野 良亮, 木村 健二郎, 山添 定明, 大平 豪, 福岡 達成, 田村 達郎, 渋谷 雅常, 永原 央, 豊川 貴弘, 田中 浩明, 六車 一哉, 八代 正和, 前田 清, 平川 弘聖, 大平 雅一

    日本外科学会定期学術集会抄録集   118回   2418 - 2418   2018.04

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  • 上部消化管癌周術期における予後規定因子 Stage II/III胃癌における予後予測因子としての炎症・栄養指標の意義

    豊川 貴弘, 六車 一哉, 田村 達郎, 福岡 達成, 大平 豪, 渋谷 雅常, 櫻井 克宜, 山添 定明, 木村 健二郎, 永原 央, 天野 良亮, 田中 浩明, 久保 尚士, 八代 正和, 前田 清, 平川 弘聖, 大平 雅一

    日本外科学会定期学術集会抄録集   118回   666 - 666   2018.04

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  • スキルス胃癌由来エキソソームが腹膜微小環境におよぼす影響

    奥野 倫久, 八代 正和, 三木 友一朗, 黒田 顕慈, 栂野 真吾, 笠島 裕明, 中前 博久, 中根 孝彦, 日野 雅之, 平川 弘聖, 大平 雅一

    日本外科学会定期学術集会抄録集   118回   1299 - 1299   2018.04

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  • 胃癌における胃漿膜捺印細胞診による術後再発予測および再発予防に関する臨床試験

    三木 友一朗, 八代 正和, 奥野 倫久, 北山 紀州, 田村 達郎, 豊川 貴弘, 田中 浩明, 六車 一哉, 平川 弘聖, 大平 雅一

    日本消化器病学会雑誌   115 ( 臨増総会 )   A253 - A253   2018.04( ISSN:0446-6586

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  • 食道癌患者における筋肉量減少率と臨床病理学的因子の関連

    田村 達郎, 櫻井 克宣, 豊川 貴弘, 天野 良亮, 久保 尚士, 田中 浩明, 六車 一哉, 八代 正和, 前田 清, 平川 弘聖, 大平 雅一

    日本外科学会定期学術集会抄録集   118回   2332 - 2332   2018.04

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  • 門脈浸潤陽性遠位胆管癌に関する検討

    山添 定明, 天野 良亮, 木村 健二郎, 大平 豪, 田内 潤, 田中 涼太, 福岡 達成, 田村 達郎, 渋谷 雅常, 永原 央, 豊川 貴弘, 田中 浩明, 六車 一哉, 八代 正和, 前田 清, 平川 弘聖, 大平 雅一

    日本外科学会定期学術集会抄録集   118回   2409 - 2409   2018.04

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  • 進行胃癌に対する漿膜捺印細胞診および擦過細胞RT-PCR法による胃癌術後再発予測

    栂野 真吾, 八代 正和, 三木 友一朗, 奥野 倫久, 黒田 顕慈, 田村 達郎, 櫻井 克宣, 豊川 貴弘, 久保 尚士, 木村 健二郎, 天野 良亮, 田中 浩明, 六車 一哉, 平川 弘聖, 大平 雅一

    日本外科学会定期学術集会抄録集   118回   1293 - 1293   2018.04

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  • 腹腔鏡下脾臓温存膵体尾部切除術後の脾静脈閉塞例の検討

    木村 健二郎, 天野 良亮, 山添 定明, 大平 豪, 田内 潤, 田中 涼太, 福岡 達成, 田村 達郎, 永原 央, 豊川 貴弘, 田中 浩明, 六車 一哉, 前田 清, 八代 正和, 平川 弘聖, 大平 雅一

    日本外科学会定期学術集会抄録集   118回   1717 - 1717   2018.04

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  • 腫瘍炎症環境において間質に依存する胃癌進展の分子メカニズム

    石本 崇胤, 三宅 慧輔, 八代 正和, 内原 智幸, 有馬 浩太, 泉 大輔, 岩槻 政晃, 馬場 祥史, 渡邊 雅之, Tan Patrick, 馬場 秀夫

    日本外科学会定期学術集会抄録集   118回   961 - 961   2018.04

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  • 胃癌患者におけるCEA陽性血中循環腫瘍細胞(CTC)同定及びその臨床的意義

    黒田 顕慈, 八代 正和, 三木 友一朗, 奥野 倫久, 栂野 真吾, 田村 達郎, 櫻井 克宜, 豊川 貴弘, 久保 尚士, 木村 健二郎, 田中 浩明, 六車 一哉, 平川 弘聖, 大平 雅一

    日本外科学会定期学術集会抄録集   118回   954 - 954   2018.04

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  • スキルス胃癌由来エキソソームが腹膜中皮細胞におよぼす影響(Effect of exosomes from scirrhous gastric cancer cells on the peritoneal mesothelial cells) Reviewed

    奥野 倫久, 八代 正和, 三木 友一朗, 栂野 真吾, 黒田 顕慈, 北山 紀州, 笠島 裕明, 中前 博久, 中根 孝彦, 日野 雅之, 平川 弘聖, 大平 雅一

    (一社)日本胃癌学会, 日本胃癌学会総会記事   90回   275 - 275   2018.03

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  • DNA脱メチル化剤は胃癌に対して化学療法の感受性を改善する(DNA demethylating agents enhance sensitivity of gastric cancer cell to cytotoxic drugs) Reviewed

    茂呂 浩史, 服部 奈緒子, 中村 能章, 前田 将宏, 八代 正和, 牛島 俊和

    (一社)日本胃癌学会, 日本胃癌学会総会記事   90回   553 - 553   2018.03

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  • 切除不能進行・再発胃癌に対するPaclitaxel+Ramucirumab併用療法の治療成績(Clinical experience of paclitaxel+ ramucirumab therapy for unresectable or recurrent gastric cancer) Reviewed

    辻尾 元, 豊川 貴弘, 田村 達郎, 大平 豪, 澁谷 雅常, 山添 定明, 木村 健二郎, 永原 央, 天野 良亮, 田中 浩明, 六車 一哉, 八代 正和, 前田 清, 平川 弘聖, 大平 雅一

    (一社)日本胃癌学会, 日本胃癌学会総会記事   90回   402 - 402   2018.03

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  • 胃癌の微小環境からみた腫瘍免疫の基礎 Reviewed

    田中 浩明, 田村 達郎, 吉井 真美, 大北 仁裕, 徳本 真央, 呉 幸枝, 崎村 千恵, 平松 宗一郎, 西村 潤也, 山越 義仁, 三木 友一朗, 豊川 貴弘, 六車 一哉, 八代 正和, 平川 弘聖, 大平 雅一

    (一社)日本胃癌学会, 日本胃癌学会総会記事   90回   205 - 205   2018.03

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  • 癌先進部-漿膜間距離と胃癌術後再発との関連性(Correlation between recurrence and microscopic distance from tumor front to serosa in gastric cancer) Reviewed

    栂野 真吾, 八代 正和, 三木 友一朗, 奥野 倫久, 黒田 顕慈, 田村 達郎, 櫻井 克宣, 豊川 貴弘, 久保 尚士, 天野 良亮, 田中 浩明, 六車 一哉, 平川 弘聖, 大平 雅一

    (一社)日本胃癌学会, 日本胃癌学会総会記事   90回   285 - 285   2018.03

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  • 捺印細胞診、擦過細胞RT-PCRを用いた術後再発予測および、捺印細胞診を用いた前向き第II相試験(Serosal stamp cytology plus RT-PCR for predicting peritoneal metastasis) Reviewed

    三木 友一朗, 八代 正和, 増田 剛, 笠島 裕明, 北山 紀州, 奥野 倫久, 櫻井 克宣, 豊川 貴弘, 久保 尚士, 木村 健二郎, 天野 良亮, 田中 浩明, 六車 一哉, 平川 弘聖, 大平 雅一

    (一社)日本胃癌学会, 日本胃癌学会総会記事   90回   278 - 278   2018.03

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  • 慢性腎臓病を伴う高齢胃癌患者の治療成績 Reviewed

    出口 惣大, 櫻井 克宣, 久保 尚士, 玉森 豊, 西居 孝文, 日月 亜紀子, 井上 透, 田村 達郎, 豊川 貴弘, 田中 浩明, 六車 一哉, 八代 正和, 西口 幸雄, 平川 弘聖, 大平 雄一

    (一社)日本胃癌学会, 日本胃癌学会総会記事   90回   511 - 511   2018.03

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  • 胃癌手術症例における筋肉量と術後QOLとの関連について(The Associations between Muscle Mass and Quality of Life after Gastrectomy for Gastric Cancer) Reviewed

    杉本 敦史, 田村 達郎, 櫻井 克宣, 豊川 貴弘, 久保 尚士, 田中 浩明, 六車 一哉, 渋谷 雅常, 山添 定明, 永原 央, 木村 健二郎, 天野 良亮, 八代 正和, 前田 清, 平川 弘聖, 大平 雅一

    (一社)日本胃癌学会, 日本胃癌学会総会記事   90回   477 - 477   2018.03

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  • 重度の併存疾患を伴う胃癌症例の手術成績(Surgical results of the gastric cancer patients with severe comorbidities) Reviewed

    田村 達郎, 櫻井 克宣, 豊川 貴弘, 久保 尚士, 田中 浩明, 六車 一哉, 大平 豪, 渋谷 雅常, 山添 定明, 永原 央, 木村 健二郎, 天野 良亮, 八代 正和, 前田 清, 平川 弘聖, 大平 雅一

    (一社)日本胃癌学会, 日本胃癌学会総会記事   90回   515 - 515   2018.03

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  • 胃癌症例の間質細胞におけるglypican-1発現の意義(Clinicopathological significance of glypican-1 expression on tumor stromal cells in gastric cancer) Reviewed

    黒田 顕慈, 八代 正和, 三木 友一朗, 奥野 倫久, 栂野 真吾, 久保 尚士, 櫻井 克宣, 豊川 貴弘, 田中 浩明, 六車 一哉, 平川 弘聖, 大平 雅一

    (一社)日本胃癌学会, 日本胃癌学会総会記事   90回   265 - 265   2018.03

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  • DNA脱メチル化剤は胃癌に対して化学療法の感受性を改善する(DNA demethylating agents enhance sensitivity of gastric cancer cell to cytotoxic drugs)

    茂呂 浩史, 服部 奈緒子, 中村 能章, 前田 将宏, 八代 正和, 牛島 俊和

    日本胃癌学会総会記事   90回   553 - 553   2018.03

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  • スキルス胃癌由来エキソソームが腹膜中皮細胞におよぼす影響(Effect of exosomes from scirrhous gastric cancer cells on the peritoneal mesothelial cells)

    奥野 倫久, 八代 正和, 三木 友一朗, 栂野 真吾, 黒田 顕慈, 北山 紀州, 笠島 裕明, 中前 博久, 中根 孝彦, 日野 雅之, 平川 弘聖, 大平 雅一

    日本胃癌学会総会記事   90回   275 - 275   2018.03

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  • 癌先進部-漿膜間距離と胃癌術後再発との関連性(Correlation between recurrence and microscopic distance from tumor front to serosa in gastric cancer)

    栂野 真吾, 八代 正和, 三木 友一朗, 奥野 倫久, 黒田 顕慈, 田村 達郎, 櫻井 克宣, 豊川 貴弘, 久保 尚士, 天野 良亮, 田中 浩明, 六車 一哉, 平川 弘聖, 大平 雅一

    日本胃癌学会総会記事   90回   285 - 285   2018.03

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  • 捺印細胞診、擦過細胞RT-PCRを用いた術後再発予測および、捺印細胞診を用いた前向き第II相試験(Serosal stamp cytology plus RT-PCR for predicting peritoneal metastasis)

    三木 友一朗, 八代 正和, 増田 剛, 笠島 裕明, 北山 紀州, 奥野 倫久, 櫻井 克宣, 豊川 貴弘, 久保 尚士, 木村 健二郎, 天野 良亮, 田中 浩明, 六車 一哉, 平川 弘聖, 大平 雅一

    日本胃癌学会総会記事   90回   278 - 278   2018.03

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  • 慢性腎臓病を伴う高齢胃癌患者の治療成績

    出口 惣大, 櫻井 克宣, 久保 尚士, 玉森 豊, 西居 孝文, 日月 亜紀子, 井上 透, 田村 達郎, 豊川 貴弘, 田中 浩明, 六車 一哉, 八代 正和, 西口 幸雄, 平川 弘聖, 大平 雄一

    日本胃癌学会総会記事   90回   511 - 511   2018.03

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  • 切除不能進行・再発胃癌に対するPaclitaxel+Ramucirumab併用療法の治療成績(Clinical experience of paclitaxel+ ramucirumab therapy for unresectable or recurrent gastric cancer)

    辻尾 元, 豊川 貴弘, 田村 達郎, 大平 豪, 澁谷 雅常, 山添 定明, 木村 健二郎, 永原 央, 天野 良亮, 田中 浩明, 六車 一哉, 八代 正和, 前田 清, 平川 弘聖, 大平 雅一

    日本胃癌学会総会記事   90回   402 - 402   2018.03

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  • 胃癌の微小環境からみた腫瘍免疫の基礎

    田中 浩明, 田村 達郎, 吉井 真美, 大北 仁裕, 徳本 真央, 呉 幸枝, 崎村 千恵, 平松 宗一郎, 西村 潤也, 山越 義仁, 三木 友一朗, 豊川 貴弘, 六車 一哉, 八代 正和, 平川 弘聖, 大平 雅一

    日本胃癌学会総会記事   90回   205 - 205   2018.03

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  • 重度の併存疾患を伴う胃癌症例の手術成績(Surgical results of the gastric cancer patients with severe comorbidities)

    田村 達郎, 櫻井 克宣, 豊川 貴弘, 久保 尚士, 田中 浩明, 六車 一哉, 大平 豪, 渋谷 雅常, 山添 定明, 永原 央, 木村 健二郎, 天野 良亮, 八代 正和, 前田 清, 平川 弘聖, 大平 雅一

    日本胃癌学会総会記事   90回   515 - 515   2018.03

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  • 胃癌症例の間質細胞におけるglypican-1発現の意義(Clinicopathological significance of glypican-1 expression on tumor stromal cells in gastric cancer)

    黒田 顕慈, 八代 正和, 三木 友一朗, 奥野 倫久, 栂野 真吾, 久保 尚士, 櫻井 克宣, 豊川 貴弘, 田中 浩明, 六車 一哉, 平川 弘聖, 大平 雅一

    日本胃癌学会総会記事   90回   265 - 265   2018.03

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  • 胃癌手術症例における筋肉量と術後QOLとの関連について(The Associations between Muscle Mass and Quality of Life after Gastrectomy for Gastric Cancer)

    杉本 敦史, 田村 達郎, 櫻井 克宣, 豊川 貴弘, 久保 尚士, 田中 浩明, 六車 一哉, 渋谷 雅常, 山添 定明, 永原 央, 木村 健二郎, 天野 良亮, 八代 正和, 前田 清, 平川 弘聖, 大平 雅一

    日本胃癌学会総会記事   90回   477 - 477   2018.03

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  • 【腫瘍免疫研究の最前線】胃癌局所の免疫細胞浸潤とその意義 Reviewed

    田中 浩明, 田村 達郎, 大北 仁裕, 吉井 真美, 徳本 真央, 呉 幸枝, 崎村 千恵, 平松 宗一郎, 西村 潤也, 山越 義仁, 八代 正和, 三木 友一朗, 豊川 貴弘, 六車 一哉, 平川 弘聖, 大平 雅一

    (株)癌と化学療法社 癌と化学療法   45 ( 2 )   217 - 221   2018.02( ISSN:0385-0684

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    浸潤する免疫細胞と癌の予後との関連性については、これまでに多くの報告がある。一般的に癌細胞は生体内の免疫監視システムから逃避し増殖すると考えられている。腫瘍免疫抑制機構に関連する細胞には、マクロファージや制御性T細胞、骨髄由来免疫抑制細胞(MDSC)、好中球などが含まれる。これらの免疫抑制細胞は、癌細胞や線維芽細胞などの間質細胞が産生するサイトカインにより、TGF-βやIL-10の産生やPDL-1の発現を増強し細胞傷害性T細胞(cytotoxic T lymphocytes:CTL)を抑制する。一方、進行胃癌であっても抗原特異的に反応するCD8+T細胞の存在が証明されており、胃癌組織内のメモリーT細胞やNK細胞やNKT細胞も良好な予後と相関する可能性が示唆されている。最近では、胃癌組織内の三次リンパ様構造(tertiary lymphoid structure:TLS)と呼ばれる濾胞リンパ系構造の存在が予後の指標になると注目されている。二次リンパ器官から距離を置いたTLS内で、腫瘍特異的な免疫応答の活性化が起こることが知られている。このように、胃癌組織内では免疫応答は抑制されているものの免疫バランスを促進方向に向かわせることが可能であり、その代表的な薬剤が免疫チェックポイント阻害剤である。2017年に免疫チェックポイント阻害剤(抗PD-1抗体)の有効性が証明され、効果予測バイオマーカーとして腫瘍浸潤免疫細胞が注目されている。また、癌ゲノム研究の進歩とともに、どのtypeに免疫応答が誘導されるか徐々に解明されつつあり今後の研究結果が期待される。このように、種々の腫瘍浸潤免疫細胞の浸潤形態や機能を評価することは、今後の胃癌に対するプレシジョン・メディシンにおいて極めて重要であると思われる。(著者抄録)

  • 【腫瘍免疫研究の最前線】 胃癌局所の免疫細胞浸潤とその意義 Reviewed

    田中 浩明, 田村 達郎, 大北 仁裕, 吉井 真美, 徳本 真央, 呉 幸枝, 崎村 千恵, 平松 宗一郎, 西村 潤也, 山越 義仁, 八代 正和, 三木 友一朗, 豊川 貴弘, 六車 一哉, 平川 弘聖, 大平 雅一

    (株)癌と化学療法社, 癌と化学療法   45 ( 2 )   217 - 221   2018.02( ISSN:0385-0684

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    浸潤する免疫細胞と癌の予後との関連性については、これまでに多くの報告がある。一般的に癌細胞は生体内の免疫監視システムから逃避し増殖すると考えられている。腫瘍免疫抑制機構に関連する細胞には、マクロファージや制御性T細胞、骨髄由来免疫抑制細胞(MDSC)、好中球などが含まれる。これらの免疫抑制細胞は、癌細胞や線維芽細胞などの間質細胞が産生するサイトカインにより、TGF-βやIL-10の産生やPDL-1の発現を増強し細胞傷害性T細胞(cytotoxic T lymphocytes:CTL)を抑制する。一方、進行胃癌であっても抗原特異的に反応するCD8+T細胞の存在が証明されており、胃癌組織内のメモリーT細胞やNK細胞やNKT細胞も良好な予後と相関する可能性が示唆されている。最近では、胃癌組織内の三次リンパ様構造(tertiary lymphoid structure:TLS)と呼ばれる濾胞リンパ系構造の存在が予後の指標になると注目されている。二次リンパ器官から距離を置いたTLS内で、腫瘍特異的な免疫応答の活性化が起こることが知られている。このように、胃癌組織内では免疫応答は抑制されているものの免疫バランスを促進方向に向かわせることが可能であり、その代表的な薬剤が免疫チェックポイント阻害剤である。2017年に免疫チェックポイント阻害剤(抗PD-1抗体)の有効性が証明され、効果予測バイオマーカーとして腫瘍浸潤免疫細胞が注目されている。また、癌ゲノム研究の進歩とともに、どのtypeに免疫応答が誘導されるか徐々に解明されつつあり今後の研究結果が期待される。このように、種々の腫瘍浸潤免疫細胞の浸潤形態や機能を評価することは、今後の胃癌に対するプレシジョン・メディシンにおいて極めて重要であると思われる。(著者抄録)

  • 回腸導管造設術後内ヘルニアの一例 Reviewed

    高橋 諒, 永森 瑞城, 福岡 達成, 前田 清, 永原 央, 渋谷 雅常, 中尾 重富, 松谷 慎治, 田村 達郎, 大平 豪, 山添 定明, 木村 健二郎, 豊川 貴弘, 天野 良亮, 田中 浩明, 六車 一哉, 八代 正和, 平川 弘聖, 大平 雅一

    (一社)日本腹部救急医学会, 日本腹部救急医学会雑誌   38 ( 2 )   347 - 347   2018.02( ISSN:1340-2242

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  • 腸瘻に起因したイレウス発症リスクの検討 Reviewed

    辻尾 元, 田村 達郎, 福岡 達成, 大平 豪, 渋谷 雅常, 山添 定明, 木村 健二郎, 永原 央, 豊川 貴弘, 天野 良亮, 田中 浩明, 六車 一哉, 八代 正和, 前田 清, 平川 弘聖, 大平 雅一

    (一社)日本腹部救急医学会, 日本腹部救急医学会雑誌   38 ( 2 )   380 - 380   2018.02( ISSN:1340-2242

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  • 食道癌術後にNOMIを発症し保存的加療にて軽快した2例 Reviewed

    田中 裕人, 田村 達郎, 豊川 貴弘, 福岡 達成, 大平 豪, 渋谷 雅常, 山添 定明, 永原 央, 木村 健二郎, 天野 良亮, 田中 浩明, 六車 一哉, 八代 正和, 前田 清, 平川 弘聖, 大平 雅一

    (一社)日本腹部救急医学会, 日本腹部救急医学会雑誌   38 ( 2 )   344 - 344   2018.02( ISSN:1340-2242

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  • 腸瘻カテーテルが先進部となった腸重積症の1例 Reviewed

    丸尾 晃司, 田村 達郎, 田内 潤, 豊川 貴弘, 福岡 達成, 大平 豪, 渋谷 雅常, 山添 定明, 永原 央, 木村 健二郎, 天野 良亮, 田中 浩明, 六車 一哉, 八代 正和, 前田 清, 平川 弘聖, 大平 雅一

    (一社)日本腹部救急医学会, 日本腹部救急医学会雑誌   38 ( 2 )   353 - 353   2018.02( ISSN:1340-2242

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  • 【腫瘍免疫研究の最前線】胃癌局所の免疫細胞浸潤とその意義 Reviewed

    田中 浩明, 田村 達郎, 大北 仁裕, 吉井 真美, 徳本 真央, 呉 幸枝, 崎村 千恵, 平松 宗一郎, 西村 潤也, 山越 義仁, 八代 正和, 三木 友一朗, 豊川 貴弘, 六車 一哉, 平川 弘聖, 大平 雅一

    癌と化学療法   45 ( 2 )   217 - 221   2018.02( ISSN:0385-0684

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    浸潤する免疫細胞と癌の予後との関連性については、これまでに多くの報告がある。一般的に癌細胞は生体内の免疫監視システムから逃避し増殖すると考えられている。腫瘍免疫抑制機構に関連する細胞には、マクロファージや制御性T細胞、骨髄由来免疫抑制細胞(MDSC)、好中球などが含まれる。これらの免疫抑制細胞は、癌細胞や線維芽細胞などの間質細胞が産生するサイトカインにより、TGF-βやIL-10の産生やPDL-1の発現を増強し細胞傷害性T細胞(cytotoxic T lymphocytes:CTL)を抑制する。一方、進行胃癌であっても抗原特異的に反応するCD8+T細胞の存在が証明されており、胃癌組織内のメモリーT細胞やNK細胞やNKT細胞も良好な予後と相関する可能性が示唆されている。最近では、胃癌組織内の三次リンパ様構造(tertiary lymphoid structure:TLS)と呼ばれる濾胞リンパ系構造の存在が予後の指標になると注目されている。二次リンパ器官から距離を置いたTLS内で、腫瘍特異的な免疫応答の活性化が起こることが知られている。このように、胃癌組織内では免疫応答は抑制されているものの免疫バランスを促進方向に向かわせることが可能であり、その代表的な薬剤が免疫チェックポイント阻害剤である。2017年に免疫チェックポイント阻害剤(抗PD-1抗体)の有効性が証明され、効果予測バイオマーカーとして腫瘍浸潤免疫細胞が注目されている。また、癌ゲノム研究の進歩とともに、どのtypeに免疫応答が誘導されるか徐々に解明されつつあり今後の研究結果が期待される。このように、種々の腫瘍浸潤免疫細胞の浸潤形態や機能を評価することは、今後の胃癌に対するプレシジョン・メディシンにおいて極めて重要であると思われる。(著者抄録)

  • 【腫瘍免疫研究の最前線】 胃癌局所の免疫細胞浸潤とその意義

    田中 浩明, 田村 達郎, 大北 仁裕, 吉井 真美, 徳本 真央, 呉 幸枝, 崎村 千恵, 平松 宗一郎, 西村 潤也, 山越 義仁, 八代 正和, 三木 友一朗, 豊川 貴弘, 六車 一哉, 平川 弘聖, 大平 雅一

    癌と化学療法   45 ( 2 )   217 - 221   2018.02( ISSN:0385-0684

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    浸潤する免疫細胞と癌の予後との関連性については、これまでに多くの報告がある。一般的に癌細胞は生体内の免疫監視システムから逃避し増殖すると考えられている。腫瘍免疫抑制機構に関連する細胞には、マクロファージや制御性T細胞、骨髄由来免疫抑制細胞(MDSC)、好中球などが含まれる。これらの免疫抑制細胞は、癌細胞や線維芽細胞などの間質細胞が産生するサイトカインにより、TGF-βやIL-10の産生やPDL-1の発現を増強し細胞傷害性T細胞(cytotoxic T lymphocytes:CTL)を抑制する。一方、進行胃癌であっても抗原特異的に反応するCD8+T細胞の存在が証明されており、胃癌組織内のメモリーT細胞やNK細胞やNKT細胞も良好な予後と相関する可能性が示唆されている。最近では、胃癌組織内の三次リンパ様構造(tertiary lymphoid structure:TLS)と呼ばれる濾胞リンパ系構造の存在が予後の指標になると注目されている。二次リンパ器官から距離を置いたTLS内で、腫瘍特異的な免疫応答の活性化が起こることが知られている。このように、胃癌組織内では免疫応答は抑制されているものの免疫バランスを促進方向に向かわせることが可能であり、その代表的な薬剤が免疫チェックポイント阻害剤である。2017年に免疫チェックポイント阻害剤(抗PD-1抗体)の有効性が証明され、効果予測バイオマーカーとして腫瘍浸潤免疫細胞が注目されている。また、癌ゲノム研究の進歩とともに、どのtypeに免疫応答が誘導されるか徐々に解明されつつあり今後の研究結果が期待される。このように、種々の腫瘍浸潤免疫細胞の浸潤形態や機能を評価することは、今後の胃癌に対するプレシジョン・メディシンにおいて極めて重要であると思われる。(著者抄録)

    Other URL: https://search-tp.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2018&ichushi_jid=J00296&link_issn=&doc_id=20180216420003&doc_link_id=%2Fab8gtkrc%2F2018%2F004502%2F003%2F0217-0221%26dl%3D0&url=https%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fab8gtkrc%2F2018%2F004502%2F003%2F0217-0221%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

  • 回腸導管造設術後内ヘルニアの一例

    高橋 諒, 永森 瑞城, 福岡 達成, 前田 清, 永原 央, 渋谷 雅常, 中尾 重富, 松谷 慎治, 田村 達郎, 大平 豪, 山添 定明, 木村 健二郎, 豊川 貴弘, 天野 良亮, 田中 浩明, 六車 一哉, 八代 正和, 平川 弘聖, 大平 雅一

    日本腹部救急医学会雑誌   38 ( 2 )   347 - 347   2018.02( ISSN:1340-2242

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    Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 腸瘻に起因したイレウス発症リスクの検討

    辻尾 元, 田村 達郎, 福岡 達成, 大平 豪, 渋谷 雅常, 山添 定明, 木村 健二郎, 永原 央, 豊川 貴弘, 天野 良亮, 田中 浩明, 六車 一哉, 八代 正和, 前田 清, 平川 弘聖, 大平 雅一

    日本腹部救急医学会雑誌   38 ( 2 )   380 - 380   2018.02( ISSN:1340-2242

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    Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 食道癌術後にNOMIを発症し保存的加療にて軽快した2例

    田中 裕人, 田村 達郎, 豊川 貴弘, 福岡 達成, 大平 豪, 渋谷 雅常, 山添 定明, 永原 央, 木村 健二郎, 天野 良亮, 田中 浩明, 六車 一哉, 八代 正和, 前田 清, 平川 弘聖, 大平 雅一

    日本腹部救急医学会雑誌   38 ( 2 )   344 - 344   2018.02( ISSN:1340-2242

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    Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 腸瘻カテーテルが先進部となった腸重積症の1例

    丸尾 晃司, 田村 達郎, 田内 潤, 豊川 貴弘, 福岡 達成, 大平 豪, 渋谷 雅常, 山添 定明, 永原 央, 木村 健二郎, 天野 良亮, 田中 浩明, 六車 一哉, 八代 正和, 前田 清, 平川 弘聖, 大平 雅一

    日本腹部救急医学会雑誌   38 ( 2 )   353 - 353   2018.02( ISSN:1340-2242

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  • 【Borderline resectable膵癌に対する集学的治療】 技術的切除可能な主要動脈浸潤局所進行膵癌に対するR0を目指した集学的治療 Reviewed

    天野 良亮, 木村 健二郎, 山添 定明, 西尾 康平, 大平 豪, 渋谷 雅常, 永原 央, 豊川 貴弘, 田中 浩明, 六車 一哉, 八代 正和, 前田 清, 平川 弘聖, 大平 雅一

    (株)篠原出版新社, 癌の臨床   63 ( 5 )   447 - 453   2018.01( ISSN:0021-4949

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    肝動脈浸潤・接触、上腸間膜動脈接触を認める局所進行膵癌42例中、膵切除を行った30例を対象とした。術前化学放射線療法の完遂率は97.6%、外科切除率は71.4%であった。NCCNガイドラインにおけるBorderline resectable(BR)が14例、Unresectable(UR)が16例で、術前治療により腫瘍径、腫瘍マーカーともに有意な低下を認めた。PD-CARやPD-CHAR、TP-CARなどの肝動脈合併膵切除症例が14例で、10例に肝動脈再建を要した。門脈合併切除は70%に行い、術中輸血率は60%であった。grade 3a以上の術後合併症発症率は36.7%であった。胃排出遅延は16.7%に認め、1例が在院死亡に至った。病理所見では、リンパ節転移例は33.3%、膵頭神経叢浸潤は43.3%、門脈浸潤率は30%であった。病理学的な90%以上の腫瘍壊死効果は43.3%に認め、R0切除率は93.3%であった。S-1による術後補助化学療法導入率は82.6%であった。2年生存率は56.1%であった。

  • 胃癌術後の筋肉量減少と臨床病理学的因子の関連 Reviewed

    田村 達郎, 櫻井 克宣, 渋谷 雅常, 山添 定明, 永原 央, 木村 健二郎, 豊川 貴弘, 天野 良亮, 久保 尚士, 田中 浩明, 六車 一哉, 八代 正和, 前田 清, 平川 弘聖, 大平 雅一

    (株)ジェフコーポレーション, 日本静脈経腸栄養学会雑誌   33 ( Suppl. )   348 - 348   2018.01( ISSN:2189-0161

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  • 腹腔動脈合併膵頭十二指腸切除術術後にセレン欠乏を発症した1例 Reviewed

    大平 豪, 木村 健二郎, 天野 良亮, 山添 定明, 福岡 達成, 田村 達郎, 渋谷 雅常, 永原 央, 豊川 貴弘, 田中 浩明, 六車 一哉, 八代 正和, 前田 清, 平川 弘聖, 大平 雅一

    (株)ジェフコーポレーション, 日本静脈経腸栄養学会雑誌   33 ( Suppl. )   579 - 579   2018.01( ISSN:2189-0161

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  • 【Borderline resectable膵癌に対する集学的治療】 技術的切除可能な主要動脈浸潤局所進行膵癌に対するR0を目指した集学的治療

    天野 良亮, 木村 健二郎, 山添 定明, 西尾 康平, 大平 豪, 渋谷 雅常, 永原 央, 豊川 貴弘, 田中 浩明, 六車 一哉, 八代 正和, 前田 清, 平川 弘聖, 大平 雅一

    癌の臨床   63 ( 5 )   447 - 453   2018.01( ISSN:0021-4949

     More details

    Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

    肝動脈浸潤・接触、上腸間膜動脈接触を認める局所進行膵癌42例中、膵切除を行った30例を対象とした。術前化学放射線療法の完遂率は97.6%、外科切除率は71.4%であった。NCCNガイドラインにおけるBorderline resectable(BR)が14例、Unresectable(UR)が16例で、術前治療により腫瘍径、腫瘍マーカーともに有意な低下を認めた。PD-CARやPD-CHAR、TP-CARなどの肝動脈合併膵切除症例が14例で、10例に肝動脈再建を要した。門脈合併切除は70%に行い、術中輸血率は60%であった。grade 3a以上の術後合併症発症率は36.7%であった。胃排出遅延は16.7%に認め、1例が在院死亡に至った。病理所見では、リンパ節転移例は33.3%、膵頭神経叢浸潤は43.3%、門脈浸潤率は30%であった。病理学的な90%以上の腫瘍壊死効果は43.3%に認め、R0切除率は93.3%であった。S-1による術後補助化学療法導入率は82.6%であった。2年生存率は56.1%であった。

  • 胃癌術後の筋肉量減少と臨床病理学的因子の関連

    田村 達郎, 櫻井 克宣, 渋谷 雅常, 山添 定明, 永原 央, 木村 健二郎, 豊川 貴弘, 天野 良亮, 久保 尚士, 田中 浩明, 六車 一哉, 八代 正和, 前田 清, 平川 弘聖, 大平 雅一

    日本静脈経腸栄養学会雑誌   33 ( Suppl. )   348 - 348   2018.01( ISSN:2189-0161

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  • 腹腔動脈合併膵頭十二指腸切除術術後にセレン欠乏を発症した1例

    大平 豪, 木村 健二郎, 天野 良亮, 山添 定明, 福岡 達成, 田村 達郎, 渋谷 雅常, 永原 央, 豊川 貴弘, 田中 浩明, 六車 一哉, 八代 正和, 前田 清, 平川 弘聖, 大平 雅一

    日本静脈経腸栄養学会雑誌   33 ( Suppl. )   579 - 579   2018.01( ISSN:2189-0161

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  • Heat shock protein 72によるStromal cell-derived factor 2の保護はオキサリプラチン耐性ヒト胃癌細胞においてオキサリプラチン誘導性の細胞死を抑制する Reviewed

    高橋 克之, 田中 昌子, 八代 正和, 松本 雅記, 大塚 明日香, 中山 敬一, 泉 康雄, 永山 勝也, 三浦 克之, 岩尾 洋, 塩田 正之

    大阪市医学会, 大阪市医学会雑誌   66   40 - 41   2017.12( ISSN:0386-4103

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  • 当院における肥満大腸癌症例に対する開腹・腹腔鏡下手術の治療成績の検討 Reviewed

    辻尾 元, 福岡 達成, 前田 清, 永原 央, 澁谷 雅常, 中尾 重富, 山添 定明, 木村 健二郎, 豊川 貴弘, 天野 良亮, 田中 浩明, 六車 一哉, 八代 正和, 平川 弘聖, 大平 雅一

    (一社)日本内視鏡外科学会, 日本内視鏡外科学会雑誌   22 ( 7 )   SF103 - 05   2017.12( ISSN:1344-6703

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  • Heat shock protein 72によるStromal cell-derived factor 2の保護はオキサリプラチン耐性ヒト胃癌細胞においてオキサリプラチン誘導性の細胞死を抑制する

    高橋 克之, 田中 昌子, 八代 正和, 松本 雅記, 大塚 明日香, 中山 敬一, 泉 康雄, 永山 勝也, 三浦 克之, 岩尾 洋, 塩田 正之

    大阪市医学会雑誌   66   40 - 41   2017.12( ISSN:0386-4103

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  • 当院における肥満大腸癌症例に対する開腹・腹腔鏡下手術の治療成績の検討

    辻尾 元, 福岡 達成, 前田 清, 永原 央, 澁谷 雅常, 中尾 重富, 山添 定明, 木村 健二郎, 豊川 貴弘, 天野 良亮, 田中 浩明, 六車 一哉, 八代 正和, 平川 弘聖, 大平 雅一

    日本内視鏡外科学会雑誌   22 ( 7 )   SF103 - 05   2017.12( ISSN:1344-6703

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  • バリウム内服を契機に発症した小腸重積により診断された転移性小腸腫瘍の1例 Reviewed

    辻尾 元, 永原 央, 中尾 重富, 福岡 達成, 渋谷 雅常, 前田 清, 松谷 慎治, 木村 健二郎, 豊川 貴弘, 天野 良亮, 田中 浩明, 六車 一哉, 八代 正和, 平川 弘聖, 大平 雅一

    (株)癌と化学療法社, 癌と化学療法   44 ( 12 )   1973 - 1975   2017.11( ISSN:0385-0684

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    症例は48歳、男性。受診2日前より嘔気を自覚、翌日に健康診断を受診し、胸部X線検査および食道・胃・十二指腸造影検査を施行した。胸部に異常陰影を指摘されたため当院に紹介受診となった。胸部〜骨盤部CT検査にて左肺門部に約4cm大の腫瘤を認め、小腸にtarget signを認めた。小腸重積の診断となり緊急手術の方針となった。開腹にて腹腔内を観察したところ、Treitz靱帯より約20cm、130cm肛門側の小腸に重積を認め、Hutchinson手技にて重積を解除し得た。口側の重積部では先進部に腫瘍を認めたが、肛門側の重積部では先進部に明らかな腫瘍性病変は認めずバリウム内服による蠕動亢進が原因と考えた。検索を進めたところ小腸に3ヶ所腫瘍性病変を認め、1ヶ所は口側腸重積の先進部となっていた。腫瘍を有する部位の小腸計3ヶ所を部分切除・再建し手術を終了した。病理組織検査では肺多型癌小腸転移の診断となり、現在外来で加療中である。(著者抄録)

  • 前立腺浸潤が疑われた局所進行直腸癌に対し腹腔鏡下に手術を施行した1例 Reviewed

    永原 央, 中尾 重富, 福岡 達成, 渋谷 雅常, 前田 清, 松谷 慎治, 土井 洋輔, 大谷 博, 山崎 健史, 天野 良亮, 田中 浩明, 六車 一哉, 八代 正和, 平川 弘聖, 大平 雅一

    (株)癌と化学療法社, 癌と化学療法   44 ( 12 )   1523 - 1525   2017.11( ISSN:0385-0684

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    症例は58歳、男性。肛門痛、血便を主訴に他院を受診し、前立腺浸潤を伴う直腸癌と診断、人工肛門造設術を施行され、術前化学療法としてmFOLFOX6を6コース施行後、手術目的に当院を紹介受診となった。術前評価はPRであったが前立腺の浸潤は残存していると判断し、腹腔鏡下に腹会陰式直腸切断術、前立腺合併切除、尿道膀胱吻合による尿路再建を行い、術後第10病日に軽快退院となった。術後2年を経過した現在、明らかな排尿障害、残尿は認めず無再発生存中である。本術式は良好な術野が得られ、確実な切除が得られる点で非常に有用な術式であると思われた。(著者抄録)

  • バリウム内服を契機に発症した小腸重積により診断された転移性小腸腫瘍の1例

    辻尾 元, 永原 央, 中尾 重富, 福岡 達成, 渋谷 雅常, 前田 清, 松谷 慎治, 木村 健二郎, 豊川 貴弘, 天野 良亮, 田中 浩明, 六車 一哉, 八代 正和, 平川 弘聖, 大平 雅一

    癌と化学療法   44 ( 12 )   1973 - 1975   2017.11( ISSN:0385-0684

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    症例は48歳、男性。受診2日前より嘔気を自覚、翌日に健康診断を受診し、胸部X線検査および食道・胃・十二指腸造影検査を施行した。胸部に異常陰影を指摘されたため当院に紹介受診となった。胸部〜骨盤部CT検査にて左肺門部に約4cm大の腫瘤を認め、小腸にtarget signを認めた。小腸重積の診断となり緊急手術の方針となった。開腹にて腹腔内を観察したところ、Treitz靱帯より約20cm、130cm肛門側の小腸に重積を認め、Hutchinson手技にて重積を解除し得た。口側の重積部では先進部に腫瘍を認めたが、肛門側の重積部では先進部に明らかな腫瘍性病変は認めずバリウム内服による蠕動亢進が原因と考えた。検索を進めたところ小腸に3ヶ所腫瘍性病変を認め、1ヶ所は口側腸重積の先進部となっていた。腫瘍を有する部位の小腸計3ヶ所を部分切除・再建し手術を終了した。病理組織検査では肺多型癌小腸転移の診断となり、現在外来で加療中である。(著者抄録)

  • 前立腺浸潤が疑われた局所進行直腸癌に対し腹腔鏡下に手術を施行した1例

    永原 央, 中尾 重富, 福岡 達成, 渋谷 雅常, 前田 清, 松谷 慎治, 土井 洋輔, 大谷 博, 山崎 健史, 天野 良亮, 田中 浩明, 六車 一哉, 八代 正和, 平川 弘聖, 大平 雅一

    癌と化学療法   44 ( 12 )   1523 - 1525   2017.11( ISSN:0385-0684

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    症例は58歳、男性。肛門痛、血便を主訴に他院を受診し、前立腺浸潤を伴う直腸癌と診断、人工肛門造設術を施行され、術前化学療法としてmFOLFOX6を6コース施行後、手術目的に当院を紹介受診となった。術前評価はPRであったが前立腺の浸潤は残存していると判断し、腹腔鏡下に腹会陰式直腸切断術、前立腺合併切除、尿道膀胱吻合による尿路再建を行い、術後第10病日に軽快退院となった。術後2年を経過した現在、明らかな排尿障害、残尿は認めず無再発生存中である。本術式は良好な術野が得られ、確実な切除が得られる点で非常に有用な術式であると思われた。(著者抄録)

  • ステージIII胃癌患者におけるリンパ球数とC反応性タンパク質値の予後的意義(Prognostic values of lymphocyte count and C-reactive protein in patients with Stage III gastric cancer) Reviewed

    豊川 貴弘, 六車 一哉, 田村 達郎, 渋谷 雅常, 櫻井 克宜, 山添 定明, 木村 健二郎, 永原 央, 天野 良亮, 久保 尚士, 田中 浩明, 八代 正和, 前田 清, 平川 弘聖, 大平 雅一

    (一社)日本癌治療学会, 日本癌治療学会学術集会抄録集   55回   IS8 - 1   2017.10

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  • スキルス胃癌細胞由来エキソソームが腹膜組織におよぼす影響 Reviewed

    奥野 倫久, 八代 正和, 三木 友一朗, 北山 紀州, 笠島 裕明, 中前 博久, 中根 孝彦, 日野 雅之, 平川 弘聖, 大平 雅一

    (一社)日本癌治療学会, 日本癌治療学会学術集会抄録集   55回   O37 - 1   2017.10

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  • State of the art スキルス胃癌に対する分子標的治療の展開 Reviewed

    八代 正和

    (株)メディカルレビュー社, 胃がんperspective   9 ( 3 )   198 - 203   2017.10( ISSN:1883-3330

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  • State of the art スキルス胃癌に対する分子標的治療の展開 Reviewed

    八代 正和

    (株)メディカルレビュー社 胃がんperspective   9 ( 3 )   198 - 203   2017.10( ISSN:1883-3330

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  • 左半腹臥位胸腔鏡下食道切除術における左反回神経周囲リンパ節郭清の工夫 Reviewed

    豊川 貴弘, 田村 達郎, 渋谷 雅常, 櫻井 克宜, 山添 定明, 木村 健二郎, 永原 央, 天野 良亮, 久保 尚士, 田中 浩明, 六車 一哉, 八代 正和, 前田 清, 平川 弘聖, 大平 雅一

    日本臨床外科学会, 日本臨床外科学会雑誌   78 ( 増刊 )   484 - 484   2017.10( ISSN:1345-2843

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  • 結腸癌治癒切除後予後予測因子としての原発病変部位の有用性について Reviewed

    永原 央, 前田 清, 渋谷 雅常, 福岡 達成, 中尾 重富, 松谷 慎治, 大平 豪, 木村 健二郎, 豊川 貴弘, 天野 良亮, 田中 浩明, 六車 一哉, 八代 正和, 平川 弘聖, 大平 雅一

    (一社)日本癌治療学会, 日本癌治療学会学術集会抄録集   55回   P18 - 1   2017.10

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  • 炎症性腸疾患の治療戦略 潰瘍性大腸炎に対する結腸亜全摘術後二期目手術における腹腔鏡アプローチの定型化 Reviewed

    水原 央, 前田 清, 渋谷 雅常, 福岡 達成, 中尾 重富, 松谷 慎治, 辻尾 元, 木村 健二郎, 豊川 貴弘, 天野 良亮, 田中 浩明, 六車 一哉, 八代 正和, 平川 弘聖, 大平 雅一

    日本臨床外科学会, 日本臨床外科学会雑誌   78 ( 増刊 )   420 - 420   2017.10( ISSN:1345-2843

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  • 当院における肥満大腸癌症例に対する開腹・腹腔鏡下手術の治療成績の検討 Reviewed

    辻尾 元, 福岡 達成, 前田 清, 永原 央, 澁谷 雅常, 中尾 重富, 松谷 慎治, 木村 健二郎, 豊川 貴弘, 天野 良亮, 田中 浩明, 六車 一哉, 八代 正和, 平川 弘聖, 大平 雅一

    日本臨床外科学会, 日本臨床外科学会雑誌   78 ( 増刊 )   644 - 644   2017.10( ISSN:1345-2843

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  • 胃癌患者におけるCEA陽性血中循環腫瘍細胞(CTC)の臨床的意義 Reviewed

    三木 友一朗, 八代 正和, 奥野 倫久, 田村 達郎, 豊川 貴弘, 田中 浩明, 六車 一哉, 平川 弘聖, 大平 雅一

    (一社)日本癌治療学会, 日本癌治療学会学術集会抄録集   55回   P180 - 2   2017.10

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  • 食道癌患者における術後筋肉量の減少に関連する臨床病理学的因子の検討 Reviewed

    田村 達郎, 櫻井 克宣, 渋谷 雅常, 山添 定明, 永原 央, 木村 健二郎, 豊川 貴弘, 天野 良亮, 久保 尚士, 田中 浩明, 六車 一哉, 八代 正和, 前田 清, 平川 弘聖, 大平 雅一

    日本臨床外科学会, 日本臨床外科学会雑誌   78 ( 増刊 )   579 - 579   2017.10( ISSN:1345-2843

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  • 腹腔鏡下胃部分切除術を施行した胃顆粒細胞腫の一例 Reviewed

    楠 誓子, 田村 達郎, 豊川 貴弘, 田中 浩明, 六車 一哉, 八代 正和, 大平 豪, 渋谷 雅常, 山添 定明, 永原 央, 木村 健二郎, 天野 良亮, 前田 清, 平川 弘聖, 大平 雅一

    日本臨床外科学会, 日本臨床外科学会雑誌   78 ( 増刊 )   964 - 964   2017.10( ISSN:1345-2843

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  • 胃癌術前栄養状態と術後1年のQOLとの関連について Reviewed

    杉本 敦史, 田村 達郎, 大平 豪, 渋谷 雅常, 山添 定明, 永原 央, 木村 健二郎, 豊川 貴弘, 天野 良亮, 田中 浩明, 六車 一哉, 八代 正和, 前田 清, 平川 弘聖, 大平 雅一

    日本臨床外科学会, 日本臨床外科学会雑誌   78 ( 増刊 )   653 - 653   2017.10( ISSN:1345-2843

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  • 胃癌患者における術後筋肉量の減少と臨床病理学的因子の関連 Reviewed

    田村 達郎, 櫻井 克宣, 渋谷 雅常, 山添 定明, 永原 央, 木村 健二郎, 豊川 貴弘, 天野 良亮, 久保 尚士, 田中 浩明, 六車 一哉, 八代 正和, 前田 清, 平川 弘聖, 大平 雅一

    (一社)日本癌治療学会, 日本癌治療学会学術集会抄録集   55回   O36 - 5   2017.10

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  • State of the art スキルス胃癌に対する分子標的治療の展開

    八代 正和

    胃がんperspective   9 ( 3 )   198 - 203   2017.10( ISSN:1883-3330

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  • State of the art スキルス胃癌に対する分子標的治療の展開 Reviewed

    八代 正和

    胃がんperspective   9 ( 3 )   198 - 203   2017.10( ISSN:1883-3330

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  • スキルス胃癌細胞由来エキソソームが腹膜組織におよぼす影響

    奥野 倫久, 八代 正和, 三木 友一朗, 北山 紀州, 笠島 裕明, 中前 博久, 中根 孝彦, 日野 雅之, 平川 弘聖, 大平 雅一

    日本癌治療学会学術集会抄録集   55回   O37 - 1   2017.10

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  • 結腸癌治癒切除後予後予測因子としての原発病変部位の有用性について

    永原 央, 前田 清, 渋谷 雅常, 福岡 達成, 中尾 重富, 松谷 慎治, 大平 豪, 木村 健二郎, 豊川 貴弘, 天野 良亮, 田中 浩明, 六車 一哉, 八代 正和, 平川 弘聖, 大平 雅一

    日本癌治療学会学術集会抄録集   55回   P18 - 1   2017.10

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  • 炎症性腸疾患の治療戦略 潰瘍性大腸炎に対する結腸亜全摘術後二期目手術における腹腔鏡アプローチの定型化

    水原 央, 前田 清, 渋谷 雅常, 福岡 達成, 中尾 重富, 松谷 慎治, 辻尾 元, 木村 健二郎, 豊川 貴弘, 天野 良亮, 田中 浩明, 六車 一哉, 八代 正和, 平川 弘聖, 大平 雅一

    日本臨床外科学会雑誌   78 ( 増刊 )   420 - 420   2017.10( ISSN:1345-2843

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  • 当院における肥満大腸癌症例に対する開腹・腹腔鏡下手術の治療成績の検討

    辻尾 元, 福岡 達成, 前田 清, 永原 央, 澁谷 雅常, 中尾 重富, 松谷 慎治, 木村 健二郎, 豊川 貴弘, 天野 良亮, 田中 浩明, 六車 一哉, 八代 正和, 平川 弘聖, 大平 雅一

    日本臨床外科学会雑誌   78 ( 増刊 )   644 - 644   2017.10( ISSN:1345-2843

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  • 左半腹臥位胸腔鏡下食道切除術における左反回神経周囲リンパ節郭清の工夫

    豊川 貴弘, 田村 達郎, 渋谷 雅常, 櫻井 克宜, 山添 定明, 木村 健二郎, 永原 央, 天野 良亮, 久保 尚士, 田中 浩明, 六車 一哉, 八代 正和, 前田 清, 平川 弘聖, 大平 雅一

    日本臨床外科学会雑誌   78 ( 増刊 )   484 - 484   2017.10( ISSN:1345-2843

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  • ステージIII胃癌患者におけるリンパ球数とC反応性タンパク質値の予後的意義(Prognostic values of lymphocyte count and C-reactive protein in patients with Stage III gastric cancer)

    豊川 貴弘, 六車 一哉, 田村 達郎, 渋谷 雅常, 櫻井 克宜, 山添 定明, 木村 健二郎, 永原 央, 天野 良亮, 久保 尚士, 田中 浩明, 八代 正和, 前田 清, 平川 弘聖, 大平 雅一

    日本癌治療学会学術集会抄録集   55回   IS8 - 1   2017.10

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  • 胃癌患者におけるCEA陽性血中循環腫瘍細胞(CTC)の臨床的意義

    三木 友一朗, 八代 正和, 奥野 倫久, 田村 達郎, 豊川 貴弘, 田中 浩明, 六車 一哉, 平川 弘聖, 大平 雅一

    日本癌治療学会学術集会抄録集   55回   P180 - 2   2017.10

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  • 食道癌患者における術後筋肉量の減少に関連する臨床病理学的因子の検討

    田村 達郎, 櫻井 克宣, 渋谷 雅常, 山添 定明, 永原 央, 木村 健二郎, 豊川 貴弘, 天野 良亮, 久保 尚士, 田中 浩明, 六車 一哉, 八代 正和, 前田 清, 平川 弘聖, 大平 雅一

    日本臨床外科学会雑誌   78 ( 増刊 )   579 - 579   2017.10( ISSN:1345-2843

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  • 腹腔鏡下胃部分切除術を施行した胃顆粒細胞腫の一例

    楠 誓子, 田村 達郎, 豊川 貴弘, 田中 浩明, 六車 一哉, 八代 正和, 大平 豪, 渋谷 雅常, 山添 定明, 永原 央, 木村 健二郎, 天野 良亮, 前田 清, 平川 弘聖, 大平 雅一

    日本臨床外科学会雑誌   78 ( 増刊 )   964 - 964   2017.10( ISSN:1345-2843

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  • 胃癌術前栄養状態と術後1年のQOLとの関連について

    杉本 敦史, 田村 達郎, 大平 豪, 渋谷 雅常, 山添 定明, 永原 央, 木村 健二郎, 豊川 貴弘, 天野 良亮, 田中 浩明, 六車 一哉, 八代 正和, 前田 清, 平川 弘聖, 大平 雅一

    日本臨床外科学会雑誌   78 ( 増刊 )   653 - 653   2017.10( ISSN:1345-2843

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  • 胃癌患者における術後筋肉量の減少と臨床病理学的因子の関連

    田村 達郎, 櫻井 克宣, 渋谷 雅常, 山添 定明, 永原 央, 木村 健二郎, 豊川 貴弘, 天野 良亮, 久保 尚士, 田中 浩明, 六車 一哉, 八代 正和, 前田 清, 平川 弘聖, 大平 雅一

    日本癌治療学会学術集会抄録集   55回   O36 - 5   2017.10

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  • DNA脱メチル化剤は胃癌におけるイリノテカンの感受性を改善する Reviewed

    茂呂 浩史, 服部 奈緒子, 中村 能章, 八代 正和, 牛島 俊和

    日本癌学会, 日本癌学会総会記事   76回   P - 1163   2017.09( ISSN:0546-0476

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  • スキルス胃癌微小環境における細胞外小胞の機能 Reviewed

    内藤 寛, 山本 雄介, 吉岡 祐亮, 八代 正和, 清野 透, 平川 弘聖, 柳原 五吉, 安井 弥, 落谷 孝広

    日本癌学会, 日本癌学会総会記事   76回   J - 2076   2017.09( ISSN:0546-0476

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  • スキルス胃癌における癌関連線維芽細胞由来CD9陽性エキソソームの意義 Reviewed

    三木 友一朗, 八代 正和, 奥野 倫久, 田村 達郎, 豊川 貴弘, 田中 浩明, 六車 一哉, 平川 弘聖, 大平 雅一

    日本癌学会, 日本癌学会総会記事   76回   J - 3107   2017.09( ISSN:0546-0476

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  • Stage II胃癌における炎症・栄養マーカーの予後因子としての意義 Reviewed

    豊川 貴弘, 六車 一哉, 田村 達郎, 渋谷 雅常, 山添 定明, 木村 健二郎, 永原 央, 天野 良亮, 田中 浩明, 八代 正和, 前田 清, 平川 弘聖, 大平 雅一

    日本癌学会, 日本癌学会総会記事   76回   P - 3241   2017.09( ISSN:0546-0476

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  • Stage II・III結腸癌における予後予測因子としての原発病変部位について Reviewed

    永原 央, 前田 清, 渋谷 雅常, 福岡 達成, 中尾 重富, 松谷 慎治, 井関 康仁, 北山 紀州, 三木 友一朗, 田村 達郎, 大平 豪, 山添 定明, 木村 健二郎, 豊川 貴弘, 天野 良亮, 田中 浩明, 六車 一哉, 八代 正和, 平川 弘聖, 大平 雅一

    (一社)日本大腸肛門病学会, 日本大腸肛門病学会雑誌   70 ( 抄録号 )   A101 - A101   2017.09( ISSN:0047-1801

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    DOI: 10.3862/jcoloproctology.70.Mics10_1

  • Hsp72によるSDF-2の分解抑制はオキサリプラチン耐性の一因である Reviewed

    塩田 正之, 高橋 克之, 八代 正和, 田中 昌子

    日本癌学会, 日本癌学会総会記事   76回   J - 1017   2017.09( ISSN:0546-0476

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  • FGFR2陽性スキルス胃癌細胞株OCUM-14の樹立とその特性 Reviewed

    奥野 倫久, 八代 正和, 増田 剛, 北山 紀州, 平川 弘聖, 大平 雅一

    日本癌学会, 日本癌学会総会記事   76回   P - 2150   2017.09( ISSN:0546-0476

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  • 局所進行直腸癌患者の術前化学放射線治療による腸腰筋面積測定の有用性 Reviewed

    福岡 達成, 前田 清, 永原 央, 渋谷 雅常, 中尾 重富, 松谷 愼治, 田村 達郎, 大平 豪, 山添 定明, 木村 健二郎, 豊川 貴弘, 天野 良亮, 田中 浩明, 六車 一哉, 八代 正和, 平川 弘聖, 大平 雅一

    (一社)日本大腸肛門病学会, 日本大腸肛門病学会雑誌   70 ( 抄録号 )   A171 - A171   2017.09( ISSN:0047-1801

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  • 胃癌における腫瘍内B細胞による腫瘍浸潤リンパ球誘導の可能性 Reviewed

    田中 浩明, 崎村 千恵, 六車 一哉, 田村 達郎, 渋谷 雅常, 木村 健二郎, 永原 央, 豊川 貴弘, 天野 良亮, 八代 正和, 平川 弘聖, 大平 雅一

    日本癌学会, 日本癌学会総会記事   76回   E - 3003   2017.09( ISSN:0546-0476

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  • 腫瘍間質に依存するdiffuse-type胃癌浸潤の新しい分子機構の解明 Reviewed

    石本 崇胤, 三宅 慧輔, 八代 正和, 江藤 二男, 有馬 浩太, 泉 大輔, 馬場 祥史, 平川 弘聖, タン・パトリック, 馬場 秀夫

    日本癌学会, 日本癌学会総会記事   76回   E - 2021   2017.09( ISSN:0546-0476

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  • 閉塞性虫垂炎による腹腔内膿瘍膀胱穿通をきたした虫垂癌の1例 Reviewed

    辻尾 元, 永原 央, 前田 清, 澁谷 雅常, 福岡 建成, 中尾 重富, 松谷 慎治, 田村 達郎, 大平 豪, 山添 定明, 木村 健二郎, 豊川 貴弘, 天野 良亮, 田中 浩明, 六車 一哉, 八代 正和, 平川 弘聖, 大平 雅一

    (一社)日本大腸肛門病学会, 日本大腸肛門病学会雑誌   70 ( 抄録号 )   A301 - A301   2017.09( ISSN:0047-1801

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  • DNA脱メチル化剤は胃癌におけるイリノテカンの感受性を改善する

    茂呂 浩史, 服部 奈緒子, 中村 能章, 八代 正和, 牛島 俊和

    日本癌学会総会記事   76回   P - 1163   2017.09( ISSN:0546-0476

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  • Stage II胃癌における炎症・栄養マーカーの予後因子としての意義

    豊川 貴弘, 六車 一哉, 田村 達郎, 渋谷 雅常, 山添 定明, 木村 健二郎, 永原 央, 天野 良亮, 田中 浩明, 八代 正和, 前田 清, 平川 弘聖, 大平 雅一

    日本癌学会総会記事   76回   P - 3241   2017.09( ISSN:0546-0476

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  • Stage II・III結腸癌における予後予測因子としての原発病変部位について

    永原 央, 前田 清, 渋谷 雅常, 福岡 達成, 中尾 重富, 松谷 慎治, 井関 康仁, 北山 紀州, 三木 友一朗, 田村 達郎, 大平 豪, 山添 定明, 木村 健二郎, 豊川 貴弘, 天野 良亮, 田中 浩明, 六車 一哉, 八代 正和, 平川 弘聖, 大平 雅一

    日本大腸肛門病学会雑誌   70 ( 抄録号 )   A101 - A101   2017.09( ISSN:0047-1801

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    DOI: 10.3862/jcoloproctology.70.Mics10_1

  • Hsp72によるSDF-2の分解抑制はオキサリプラチン耐性の一因である

    塩田 正之, 高橋 克之, 八代 正和, 田中 昌子

    日本癌学会総会記事   76回   J - 1017   2017.09( ISSN:0546-0476

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  • FGFR2陽性スキルス胃癌細胞株OCUM-14の樹立とその特性

    奥野 倫久, 八代 正和, 増田 剛, 北山 紀州, 平川 弘聖, 大平 雅一

    日本癌学会総会記事   76回   P - 2150   2017.09( ISSN:0546-0476

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  • スキルス胃癌における癌関連線維芽細胞由来CD9陽性エキソソームの意義

    三木 友一朗, 八代 正和, 奥野 倫久, 田村 達郎, 豊川 貴弘, 田中 浩明, 六車 一哉, 平川 弘聖, 大平 雅一

    日本癌学会総会記事   76回   J - 3107   2017.09( ISSN:0546-0476

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  • 局所進行直腸癌患者の術前化学放射線治療による腸腰筋面積測定の有用性

    福岡 達成, 前田 清, 永原 央, 渋谷 雅常, 中尾 重富, 松谷 愼治, 田村 達郎, 大平 豪, 山添 定明, 木村 健二郎, 豊川 貴弘, 天野 良亮, 田中 浩明, 六車 一哉, 八代 正和, 平川 弘聖, 大平 雅一

    日本大腸肛門病学会雑誌   70 ( 抄録号 )   A171 - A171   2017.09( ISSN:0047-1801

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  • スキルス胃癌微小環境における細胞外小胞の機能

    内藤 寛, 山本 雄介, 吉岡 祐亮, 八代 正和, 清野 透, 平川 弘聖, 柳原 五吉, 安井 弥, 落谷 孝広

    日本癌学会総会記事   76回   J - 2076   2017.09( ISSN:0546-0476

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  • 胃癌における腫瘍内B細胞による腫瘍浸潤リンパ球誘導の可能性

    田中 浩明, 崎村 千恵, 六車 一哉, 田村 達郎, 渋谷 雅常, 木村 健二郎, 永原 央, 豊川 貴弘, 天野 良亮, 八代 正和, 平川 弘聖, 大平 雅一

    日本癌学会総会記事   76回   E - 3003   2017.09( ISSN:0546-0476

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  • 閉塞性虫垂炎による腹腔内膿瘍膀胱穿通をきたした虫垂癌の1例

    辻尾 元, 永原 央, 前田 清, 澁谷 雅常, 福岡 建成, 中尾 重富, 松谷 慎治, 田村 達郎, 大平 豪, 山添 定明, 木村 健二郎, 豊川 貴弘, 天野 良亮, 田中 浩明, 六車 一哉, 八代 正和, 平川 弘聖, 大平 雅一

    日本大腸肛門病学会雑誌   70 ( 抄録号 )   A301 - A301   2017.09( ISSN:0047-1801

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  • 腫瘍間質に依存するdiffuse-type胃癌浸潤の新しい分子機構の解明

    石本 崇胤, 三宅 慧輔, 八代 正和, 江藤 二男, 有馬 浩太, 泉 大輔, 馬場 祥史, 平川 弘聖, タン・パトリック, 馬場 秀夫

    日本癌学会総会記事   76回   E - 2021   2017.09( ISSN:0546-0476

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  • 腹腔鏡下低位前方切除術における腸閉塞および縫合不全予防の工夫 Reviewed

    永原 央, 前田 清, 渋谷 雅常, 大谷 博, 中尾 重富, 福岡 達成, 松谷 慎治, 大平 豪, 田村 達郎, 山添 定明, 木村 健二郎, 豊川 貴弘, 天野 良亮, 田中 浩明, 六車 一哉, 八代 正和, 平川 弘聖, 大平 雅一

    (一社)日本大腸肛門病学会, 日本大腸肛門病学会雑誌   70 ( 8 )   577 - 577   2017.08( ISSN:0047-1801

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  • 腹腔鏡下低位前方切除術における腸閉塞および縫合不全予防の工夫

    永原 央, 前田 清, 渋谷 雅常, 大谷 博, 中尾 重富, 福岡 達成, 松谷 慎治, 大平 豪, 田村 達郎, 山添 定明, 木村 健二郎, 豊川 貴弘, 天野 良亮, 田中 浩明, 六車 一哉, 八代 正和, 平川 弘聖, 大平 雅一

    日本大腸肛門病学会雑誌   70 ( 8 )   577 - 577   2017.08( ISSN:0047-1801

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  • スキルス胃癌細胞由来エキソソームが前転移ニッチ(premetastatic niche)形成に及ぼす影響 Reviewed

    奥野 倫久, 八代 正和, 三木 友一郎, 北山 紀州, 笠島 裕明, 中根 孝彦, 日野 雅之, 平川 弘聖, 大平 雅一

    (一社)日本消化器外科学会, 日本消化器外科学会総会   72回   PH14 - 4   2017.07

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  • 切除不能進行・再発胃癌に対するPaclitaxel+Ramucirumab併用療法の治療成績 Reviewed

    辻尾 元, 豊川 貴弘, 田村 達郎, 天野 良亮, 田中 浩明, 六車 一哉, 八代 正和, 前田 清, 平川 弘聖, 大平 雅一

    (一社)日本消化器外科学会, 日本消化器外科学会総会   72回   PI18 - 4   2017.07

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  • 胃癌における胃漿膜捺印細胞診および擦過細胞RT-PCRによる術後再発予測 Reviewed

    三木 友一朗, 八代 正和, 奥野 倫久, 北山 紀州, 田村 達郎, 豊川 貴弘, 田中 浩明, 六車 一哉, 平川 弘聖, 大平 雅一

    (一社)日本消化器外科学会, 日本消化器外科学会総会   72回   PH16 - 4   2017.07

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  • 消化器癌腹膜播種の病態解明と新たな治療戦略 消化器癌腹膜播種の病態解明と新たな治療戦略 Reviewed

    八代 正和, 三木 友一郎, 奥野 倫久, 笠島 裕明, 平川 弘聖, 大平 雅一

    (一社)日本消化器外科学会, 日本消化器外科学会総会   72回   WS03 - 1   2017.07

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  • 胃癌患者における術前筋肉量が胃切除後合併症に与える影響 Reviewed

    田村 達郎, 櫻井 克宣, 豊川 貴弘, 久保 尚士, 田中 浩明, 六車 一哉, 八代 正和, 前田 清, 平川 弘聖, 大平 雅一

    (一社)日本消化器外科学会, 日本消化器外科学会総会   72回   PK14 - 1   2017.07

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  • スキルス胃癌細胞由来エキソソームが前転移ニッチ(premetastatic niche)形成に及ぼす影響

    奥野 倫久, 八代 正和, 三木 友一郎, 北山 紀州, 笠島 裕明, 中根 孝彦, 日野 雅之, 平川 弘聖, 大平 雅一

    日本消化器外科学会総会   72回   PH14 - 4   2017.07

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  • 消化器癌腹膜播種の病態解明と新たな治療戦略 消化器癌腹膜播種の病態解明と新たな治療戦略

    八代 正和, 三木 友一郎, 奥野 倫久, 笠島 裕明, 平川 弘聖, 大平 雅一

    日本消化器外科学会総会   72回   WS03 - 1   2017.07

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  • 切除不能進行・再発胃癌に対するPaclitaxel+Ramucirumab併用療法の治療成績

    辻尾 元, 豊川 貴弘, 田村 達郎, 天野 良亮, 田中 浩明, 六車 一哉, 八代 正和, 前田 清, 平川 弘聖, 大平 雅一

    日本消化器外科学会総会   72回   PI18 - 4   2017.07

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  • 胃癌における胃漿膜捺印細胞診および擦過細胞RT-PCRによる術後再発予測

    三木 友一朗, 八代 正和, 奥野 倫久, 北山 紀州, 田村 達郎, 豊川 貴弘, 田中 浩明, 六車 一哉, 平川 弘聖, 大平 雅一

    日本消化器外科学会総会   72回   PH16 - 4   2017.07

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  • 胃癌患者における術前筋肉量が胃切除後合併症に与える影響

    田村 達郎, 櫻井 克宣, 豊川 貴弘, 久保 尚士, 田中 浩明, 六車 一哉, 八代 正和, 前田 清, 平川 弘聖, 大平 雅一

    日本消化器外科学会総会   72回   PK14 - 1   2017.07

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  • 半腹臥位胸腔鏡下食道切除術の定型化への取り組み Reviewed

    豊川 貴弘, 田村 達郎, 久保 尚士, 櫻井 克宜, 天野 良亮, 田中 浩明, 六車 一哉, 八代 正和, 平川 弘聖, 大平 雅一

    (NPO)日本食道学会, 日本食道学会学術集会プログラム・抄録集   71回   P62 - 4   2017.06

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  • 吻合部合併症低減に向けた食道胃管吻合の手技と工夫 Reviewed

    豊川 貴弘, 田村 達郎, 久保 尚士, 櫻井 克宜, 天野 良亮, 田中 浩明, 六車 一哉, 八代 正和, 平川 弘聖, 大平 雅一

    (NPO)日本食道学会, 日本食道学会学術集会プログラム・抄録集   71回   P14 - 2   2017.06

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  • 半腹臥位胸腔鏡下食道切除術の定型化への取り組み

    豊川 貴弘, 田村 達郎, 久保 尚士, 櫻井 克宜, 天野 良亮, 田中 浩明, 六車 一哉, 八代 正和, 平川 弘聖, 大平 雅一

    日本食道学会学術集会プログラム・抄録集   71回   P62 - 4   2017.06

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  • 吻合部合併症低減に向けた食道胃管吻合の手技と工夫

    豊川 貴弘, 田村 達郎, 久保 尚士, 櫻井 克宜, 天野 良亮, 田中 浩明, 六車 一哉, 八代 正和, 平川 弘聖, 大平 雅一

    日本食道学会学術集会プログラム・抄録集   71回   P14 - 2   2017.06

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  • 直腸癌における腹腔鏡の手術成績 Reviewed

    永原 央, 前田 清, 渋谷 雅常, 大谷 博, 中尾 重富, 井関 康仁, 大平 豪, 田村 達郎, 山添 定明, 木村 健二郎, 豊川 貴弘, 天野 良亮, 田中 浩明, 六車 一哉, 八代 正和, 平川 弘聖, 大平 雅一

    (一社)日本大腸肛門病学会, 日本大腸肛門病学会雑誌   70 ( 5 )   346 - 346   2017.05( ISSN:0047-1801

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  • 進行再発胃癌に対するSOX療法の治療成績 Reviewed

    豊川 貴弘, 田村 達郎, 渋谷 雅常, 大平 豪, 山添 定明, 木村 健二郎, 永原 央, 天野 良亮, 田中 浩明, 六車 一哉, 八代 正和, 平川 弘聖, 大平 雅一

    (株)癌と化学療法社, 癌と化学療法   44 ( 5 )   405 - 408   2017.05( ISSN:0385-0684

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    進行再発胃癌に対する一次治療としてのS-1+oxaliplatin(SOX)療法の有効性と安全性について検討した。対象は当科でSOX療法を施行した進行再発胃癌27例である。投与方法はoxaliplatin 100mg/m2を第1日目に点滴静注、S-1 80〜120mg/bodyを2週投与1週休薬で投与し、3週1コースとした。投与コース中央値は7コースで、奏効率47.6%、病勢コントロール率は76.2%であった。Grade 3以上の有害事象は、好中球減少33.3%、末梢神経障害、食欲不振11.1%、血小板減少7.4%、貧血、下痢、疲労、高カルシウム血症を3.7%に認めた。生存期間中央値には到達せず、1年生存率は63.2%であった。実地臨床においてもSOX療法の治療効果は良好で、外来で安全に施行可能であった。(著者抄録)

  • 直腸癌における腹腔鏡の手術成績

    永原 央, 前田 清, 渋谷 雅常, 大谷 博, 中尾 重富, 井関 康仁, 大平 豪, 田村 達郎, 山添 定明, 木村 健二郎, 豊川 貴弘, 天野 良亮, 田中 浩明, 六車 一哉, 八代 正和, 平川 弘聖, 大平 雅一

    日本大腸肛門病学会雑誌   70 ( 5 )   346 - 346   2017.05( ISSN:0047-1801

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  • 進行再発胃癌に対するSOX療法の治療成績

    豊川 貴弘, 田村 達郎, 渋谷 雅常, 大平 豪, 山添 定明, 木村 健二郎, 永原 央, 天野 良亮, 田中 浩明, 六車 一哉, 八代 正和, 平川 弘聖, 大平 雅一

    癌と化学療法   44 ( 5 )   405 - 408   2017.05( ISSN:0385-0684

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    進行再発胃癌に対する一次治療としてのS-1+oxaliplatin(SOX)療法の有効性と安全性について検討した。対象は当科でSOX療法を施行した進行再発胃癌27例である。投与方法はoxaliplatin 100mg/m2を第1日目に点滴静注、S-1 80〜120mg/bodyを2週投与1週休薬で投与し、3週1コースとした。投与コース中央値は7コースで、奏効率47.6%、病勢コントロール率は76.2%であった。Grade 3以上の有害事象は、好中球減少33.3%、末梢神経障害、食欲不振11.1%、血小板減少7.4%、貧血、下痢、疲労、高カルシウム血症を3.7%に認めた。生存期間中央値には到達せず、1年生存率は63.2%であった。実地臨床においてもSOX療法の治療効果は良好で、外来で安全に施行可能であった。(著者抄録)

  • Borderline resectable膵癌に対する集学的治療 技術的切除可能な主要動脈浸潤局所進行膵癌に対するR0切除を目指した集学的治療 Reviewed

    天野 良亮, 木村 健二郎, 山添 定明, 大平 豪, 西尾 康平, 亀谷 直樹, 渋谷 雅常, 永原 央, 豊川 貴弘, 田中 浩明, 六車 一哉, 八代 正和, 前田 清, 平川 弘聖

    (一社)日本外科学会, 日本外科学会定期学術集会抄録集   117回   WS - 10   2017.04

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  • 切除可能cStage II-IV胸部食道扁平上皮癌の治療前予後予測因子 Reviewed

    豊川 貴弘, 田村 達郎, 大平 豪, 渋谷 雅常, 櫻井 克宜, 山添 定明, 木村 健二郎, 永原 央, 天野 良亮, 久保 尚士, 田中 浩明, 六車 一哉, 八代 正和, 前田 清, 平川 弘聖, 六平 雅一

    (一社)日本外科学会, 日本外科学会定期学術集会抄録集   117回   PS - 013   2017.04

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  • 胃癌微小環境における脂肪由来幹細胞の機能解析 Reviewed

    木下 淳, 伏田 幸夫, 尾山 勝信, 廣瀬 淳史, 岡本 浩一, 牧野 勇, 中村 慶史, 林 泰寛, 井口 雅史, 宮下 知治, 田島 秀浩, 高村 博之, 二宮 致, 八代 正和, 大平 雅一, 太田 哲生

    (一社)日本外科学会, 日本外科学会定期学術集会抄録集   117回   PS - 009   2017.04

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  • 胃癌局所における腫瘍浸潤B細胞による細胞傷害性T細胞誘導の可能性 Reviewed

    崎村 千恵, 田中 浩明, 平松 宗一郎, 田村 達郎, 山添 定明, 木村 健二郎, 豊川 貴弘, 天野 良亮, 六車 一哉, 八代 正和, 前田 清, 平川 弘聖, 大平 雅一

    (一社)日本外科学会, 日本外科学会定期学術集会抄録集   117回   PS - 009   2017.04

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  • 胃癌周囲微小環境におけるCD9陽性エクソソームの意義 Reviewed

    三木 友一朗, 八代 正和, 奥野 倫久, 北山 紀州, 田村 達郎, 豊川 貴弘, 田中 浩明, 六車 一哉, 平川 弘聖, 大平 雅一

    (一社)日本外科学会, 日本外科学会定期学術集会抄録集   117回   PS - 010   2017.04

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  • 胃がんにおける腫瘍関連好中球(TAN)と、好中球/リンパ球比(NLR)との関係 Reviewed

    平松 宗一郎, 田中 弘明, 西村 潤也, 崎村 千恵, 西尾 康平, 福岡 達成, 田村 達郎, 大平 豪, 山添 定明, 渋谷 雅常, 木村 健二郎, 永原 央, 豊川 貴弘, 天野 良亮, 六車 一哉, 八代 正和, 前田 清, 平川 弘聖, 大平 雅一

    (一社)日本外科学会, 日本外科学会定期学術集会抄録集   117回   SF - 43   2017.04

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  • 糖代謝関連酵素が低酸素状態の胃癌細胞の増殖に及ぼす影響の検討 Reviewed

    北山 紀州, 八代 正和, 森崎 珠実, 奥野 倫久, 三木 友一朗, 笠島 裕明, 増田 剛, 豊川 貴弘, 田中 浩明, 六車 一哉, 平川 弘聖, 大平 雅一

    (一社)日本外科学会, 日本外科学会定期学術集会抄録集   117回   PS - 009   2017.04

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  • 外科的切除を施行した十二指腸GIST8例の臨床病理学的検討 Reviewed

    辻尾 元, 豊川 貴弘, 田村 達郎, 大平 豪, 渋谷 雅常, 山添 定明, 木村 健二郎, 永原 央, 天野 良亮, 田中 浩明, 六車 一哉, 八代 正和, 前田 清, 平川 弘聖, 大平 雅一

    (一社)日本外科学会, 日本外科学会定期学術集会抄録集   117回   PS - 176   2017.04

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  • 胃癌患者の術前除脂肪体重と術後合併症の関連 Reviewed

    田村 達郎, 櫻井 克宣, 福岡 達成, 大平 豪, 渋谷 雅常, 山添 定明, 永原 央, 木村 健二郎, 豊川 貴弘, 天野 良介, 久保 尚士, 田中 浩明, 六車 一哉, 八代 正和, 前田 清, 平川 弘聖, 大平 雅一

    (一社)日本外科学会, 日本外科学会定期学術集会抄録集   117回   PS - 171   2017.04

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  • 腫瘍間質に依存するdiffuse-type胃癌浸潤の新しい分子機構の解明 Reviewed

    石本 崇胤, 三宅 慧輔, 八代 正和, 江藤 二男, 有馬 浩太, 泉 大輔, 岩槻 政晃, 馬場 祥史, 渡邊 雅之, 平川 弘聖, Tan Patrick, 馬場 秀夫

    (一社)日本外科学会, 日本外科学会定期学術集会抄録集   117回   SF - 44   2017.04

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  • Borderline resectable膵癌に対する集学的治療 技術的切除可能な主要動脈浸潤局所進行膵癌に対するR0切除を目指した集学的治療

    天野 良亮, 木村 健二郎, 山添 定明, 大平 豪, 西尾 康平, 亀谷 直樹, 渋谷 雅常, 永原 央, 豊川 貴弘, 田中 浩明, 六車 一哉, 八代 正和, 前田 清, 平川 弘聖

    日本外科学会定期学術集会抄録集   117回   WS - 10   2017.04

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  • 切除可能cStage II-IV胸部食道扁平上皮癌の治療前予後予測因子

    豊川 貴弘, 田村 達郎, 大平 豪, 渋谷 雅常, 櫻井 克宜, 山添 定明, 木村 健二郎, 永原 央, 天野 良亮, 久保 尚士, 田中 浩明, 六車 一哉, 八代 正和, 前田 清, 平川 弘聖, 六平 雅一

    日本外科学会定期学術集会抄録集   117回   PS - 013   2017.04

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  • 胃がんにおける腫瘍関連好中球(TAN)と、好中球/リンパ球比(NLR)との関係

    平松 宗一郎, 田中 弘明, 西村 潤也, 崎村 千恵, 西尾 康平, 福岡 達成, 田村 達郎, 大平 豪, 山添 定明, 渋谷 雅常, 木村 健二郎, 永原 央, 豊川 貴弘, 天野 良亮, 六車 一哉, 八代 正和, 前田 清, 平川 弘聖, 大平 雅一

    日本外科学会定期学術集会抄録集   117回   SF - 43   2017.04

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  • 糖代謝関連酵素が低酸素状態の胃癌細胞の増殖に及ぼす影響の検討

    北山 紀州, 八代 正和, 森崎 珠実, 奥野 倫久, 三木 友一朗, 笠島 裕明, 増田 剛, 豊川 貴弘, 田中 浩明, 六車 一哉, 平川 弘聖, 大平 雅一

    日本外科学会定期学術集会抄録集   117回   PS - 009   2017.04

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  • 外科的切除を施行した十二指腸GIST8例の臨床病理学的検討

    辻尾 元, 豊川 貴弘, 田村 達郎, 大平 豪, 渋谷 雅常, 山添 定明, 木村 健二郎, 永原 央, 天野 良亮, 田中 浩明, 六車 一哉, 八代 正和, 前田 清, 平川 弘聖, 大平 雅一

    日本外科学会定期学術集会抄録集   117回   PS - 176   2017.04

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  • 胃癌周囲微小環境におけるCD9陽性エクソソームの意義

    三木 友一朗, 八代 正和, 奥野 倫久, 北山 紀州, 田村 達郎, 豊川 貴弘, 田中 浩明, 六車 一哉, 平川 弘聖, 大平 雅一

    日本外科学会定期学術集会抄録集   117回   PS - 010   2017.04

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  • 腫瘍間質に依存するdiffuse-type胃癌浸潤の新しい分子機構の解明

    石本 崇胤, 三宅 慧輔, 八代 正和, 江藤 二男, 有馬 浩太, 泉 大輔, 岩槻 政晃, 馬場 祥史, 渡邊 雅之, 平川 弘聖, Tan Patrick, 馬場 秀夫

    日本外科学会定期学術集会抄録集   117回   SF - 44   2017.04

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  • 胃癌患者の術前除脂肪体重と術後合併症の関連

    田村 達郎, 櫻井 克宣, 福岡 達成, 大平 豪, 渋谷 雅常, 山添 定明, 永原 央, 木村 健二郎, 豊川 貴弘, 天野 良介, 久保 尚士, 田中 浩明, 六車 一哉, 八代 正和, 前田 清, 平川 弘聖, 大平 雅一

    日本外科学会定期学術集会抄録集   117回   PS - 171   2017.04

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  • 胃癌微小環境における脂肪由来幹細胞の機能解析

    木下 淳, 伏田 幸夫, 尾山 勝信, 廣瀬 淳史, 岡本 浩一, 牧野 勇, 中村 慶史, 林 泰寛, 井口 雅史, 宮下 知治, 田島 秀浩, 高村 博之, 二宮 致, 八代 正和, 大平 雅一, 太田 哲生

    日本外科学会定期学術集会抄録集   117回   PS - 009   2017.04

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  • 胃癌局所における腫瘍浸潤B細胞による細胞傷害性T細胞誘導の可能性

    崎村 千恵, 田中 浩明, 平松 宗一郎, 田村 達郎, 山添 定明, 木村 健二郎, 豊川 貴弘, 天野 良亮, 六車 一哉, 八代 正和, 前田 清, 平川 弘聖, 大平 雅一

    日本外科学会定期学術集会抄録集   117回   PS - 009   2017.04

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  • R0切除を施行したpStage III胃癌の予後因子(Prognostic factors of pStage III gastric cancer patients undergoing R0 resection) Reviewed

    豊川 貴弘, 六車 一哉, 田村 達郎, 渋谷 雅常, 大平 豪, 櫻井 克宜, 山添 定明, 木村 健二郎, 永原 央, 天野 良亮, 久保 尚士, 田中 浩明, 八代 正和, 前田 清, 平川 弘聖, 大平 雅一

    (一社)日本胃癌学会, 日本胃癌学会総会記事   89回   393 - 393   2017.03

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  • スキルス胃癌と類似した肉眼型を呈し鑑別に難渋した乳癌胃転移の1例(A Case of Gastric Metastasis from Breast Cancer that resembles Scirrhous Gastric Cancer) Reviewed

    辻尾 元, 豊川 貴弘, 田村 達郎, 大平 豪, 渋谷 雅常, 山添 定明, 木村 健二郎, 永原 央, 天野 良亮, 田中 浩明, 六車 一哉, 八代 正和, 前田 清, 平川 弘聖, 大平 雅一

    (一社)日本胃癌学会, 日本胃癌学会総会記事   89回   260 - 260   2017.03

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  • 癌微小環境における胃癌細胞の糖代謝関連酵素(PKM2、ENO1、GLS)の意義 Reviewed

    北山 紀州, 八代 正和, 森崎 珠実, 奥野 倫久, 三木 友一朗, 笠島 裕明, 増田 剛, 豊川 貴弘, 田中 浩明, 六車 一哉, 平川 弘聖, 大平 雅一

    日本分子腫瘍マーカー研究会, 日本分子腫瘍マーカー研究会誌   32   55 - 56   2017.03

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  • 直接接触相互作用によるスキルス胃癌細胞の浸潤と間質線維芽細胞の増殖促進(The cancer-stromal interaction in scirrhous-type gastric carcinoma) Reviewed

    東野 展英, 狛 雄一朗, 細野 雅義, 高瀬 信尚, 小平 日実子, 岡本 真生子, 土井 雅之, 重岡 学, 西尾 真理, 八代 正和, 平川 弘聖, 柳原 五吉, 掛地 吉弘, 横崎 宏

    (一社)日本胃癌学会, 日本胃癌学会総会記事   89回   440 - 440   2017.03

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  • 胃癌患者におけるCEA陽性CTC同定およびその臨床的意義(Identification of CEA positive Circulating tumor cells and its clinical significance) Reviewed

    三木 友一朗, 八代 正和, 北山 紀州, 奥野 倫久, 田村 達郎, 豊川 貴弘, 田中 浩明, 六車 一哉, 平川 弘聖, 大平 雅一

    (一社)日本胃癌学会, 日本胃癌学会総会記事   89回   255 - 255   2017.03

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  • 術前除脂肪体重が胃全摘術後の合併症に与える影響(Impact of preoperative lean body mass on complication following total gastrectomy) Reviewed

    田村 達郎, 櫻井 克宣, 豊川 貴弘, 天野 良亮, 久保 尚士, 田中 浩明, 六車 一哉, 八代 正和, 平川 弘聖, 大平 雅一

    (一社)日本胃癌学会, 日本胃癌学会総会記事   89回   425 - 425   2017.03

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  • 腫瘍間質ゲノム解析に基づいた胃癌浸潤を制御する新規分子機構の解明(Identification of new molecular mechanism mediating GC invasion based on genomic analysis of CAFs) Reviewed

    石本 崇胤, 三宅 慧輔, 八代 正和, 江藤 二男, 有馬 浩太, 泉 大輔, 岩槻 政晃, 馬場 祥史, 渡邊 雅之, 平川 弘聖, Tan Patrick, 馬場 秀夫

    (一社)日本胃癌学会, 日本胃癌学会総会記事   89回   231 - 231   2017.03

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  • 胃癌診療における腫瘍マーカー Reviewed

    八代 正和

    日本分子腫瘍マーカー研究会, 日本分子腫瘍マーカー研究会誌   32   10 - 10   2017.03

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  • R0切除を施行したpStage III胃癌の予後因子(Prognostic factors of pStage III gastric cancer patients undergoing R0 resection)

    豊川 貴弘, 六車 一哉, 田村 達郎, 渋谷 雅常, 大平 豪, 櫻井 克宜, 山添 定明, 木村 健二郎, 永原 央, 天野 良亮, 久保 尚士, 田中 浩明, 八代 正和, 前田 清, 平川 弘聖, 大平 雅一

    日本胃癌学会総会記事   89回   393 - 393   2017.03

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  • スキルス胃癌と類似した肉眼型を呈し鑑別に難渋した乳癌胃転移の1例(A Case of Gastric Metastasis from Breast Cancer that resembles Scirrhous Gastric Cancer)

    辻尾 元, 豊川 貴弘, 田村 達郎, 大平 豪, 渋谷 雅常, 山添 定明, 木村 健二郎, 永原 央, 天野 良亮, 田中 浩明, 六車 一哉, 八代 正和, 前田 清, 平川 弘聖, 大平 雅一

    日本胃癌学会総会記事   89回   260 - 260   2017.03

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  • 直接接触相互作用によるスキルス胃癌細胞の浸潤と間質線維芽細胞の増殖促進(The cancer-stromal interaction in scirrhous-type gastric carcinoma)

    東野 展英, 狛 雄一朗, 細野 雅義, 高瀬 信尚, 小平 日実子, 岡本 真生子, 土井 雅之, 重岡 学, 西尾 真理, 八代 正和, 平川 弘聖, 柳原 五吉, 掛地 吉弘, 横崎 宏

    日本胃癌学会総会記事   89回   440 - 440   2017.03

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  • 癌微小環境における胃癌細胞の糖代謝関連酵素(PKM2、ENO1、GLS)の意義

    北山 紀州, 八代 正和, 森崎 珠実, 奥野 倫久, 三木 友一朗, 笠島 裕明, 増田 剛, 豊川 貴弘, 田中 浩明, 六車 一哉, 平川 弘聖, 大平 雅一

    日本分子腫瘍マーカー研究会誌   32   55 - 56   2017.03

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  • 胃癌患者におけるCEA陽性CTC同定およびその臨床的意義(Identification of CEA positive Circulating tumor cells and its clinical significance)

    三木 友一朗, 八代 正和, 北山 紀州, 奥野 倫久, 田村 達郎, 豊川 貴弘, 田中 浩明, 六車 一哉, 平川 弘聖, 大平 雅一

    日本胃癌学会総会記事   89回   255 - 255   2017.03

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    Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 術前除脂肪体重が胃全摘術後の合併症に与える影響(Impact of preoperative lean body mass on complication following total gastrectomy)

    田村 達郎, 櫻井 克宣, 豊川 貴弘, 天野 良亮, 久保 尚士, 田中 浩明, 六車 一哉, 八代 正和, 平川 弘聖, 大平 雅一

    日本胃癌学会総会記事   89回   425 - 425   2017.03

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  • 腫瘍間質ゲノム解析に基づいた胃癌浸潤を制御する新規分子機構の解明(Identification of new molecular mechanism mediating GC invasion based on genomic analysis of CAFs)

    石本 崇胤, 三宅 慧輔, 八代 正和, 江藤 二男, 有馬 浩太, 泉 大輔, 岩槻 政晃, 馬場 祥史, 渡邊 雅之, 平川 弘聖, Tan Patrick, 馬場 秀夫

    日本胃癌学会総会記事   89回   231 - 231   2017.03

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  • 胃癌診療における腫瘍マーカー

    八代 正和

    日本分子腫瘍マーカー研究会誌   32   10 - 10   2017.03

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  • 超音波内視鏡下穿刺吸引術(EUS-FNA)施行後に腹膜炎を発症し緊急手術を行った尾側膵腫瘍の2例 Reviewed

    大平 豪, 天野 良亮, 木村 健二郎, 山添 定明, 西尾 康平, 福岡 達成, 田村 達郎, 渋谷 雅常, 永原 央, 豊川 貴弘, 田中 浩明, 六車 一哉, 八代 正和, 前田 清, 平川 弘聖, 大平 雅一

    (一社)日本腹部救急医学会, 日本腹部救急医学会雑誌   37 ( 2 )   347 - 348   2017.02( ISSN:1340-2242

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  • 超音波内視鏡下穿刺吸引術(EUS-FNA)施行後に腹膜炎を発症し緊急手術を行った尾側膵腫瘍の2例

    大平 豪, 天野 良亮, 木村 健二郎, 山添 定明, 西尾 康平, 福岡 達成, 田村 達郎, 渋谷 雅常, 永原 央, 豊川 貴弘, 田中 浩明, 六車 一哉, 八代 正和, 前田 清, 平川 弘聖, 大平 雅一

    日本腹部救急医学会雑誌   37 ( 2 )   347 - 348   2017.02( ISSN:1340-2242

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  • VATSによる食道亜全摘後の感染性合併症予測におけるCRPの意義 Reviewed

    三木 友一朗, 豊川 貴弘, 久保 尚士, 櫻井 克宣, 田村 達郎, 田中 浩明, 六車 一哉, 八代 正和, 平川 弘聖, 大平 雅一

    (一社)日本内視鏡外科学会, 日本内視鏡外科学会雑誌   21 ( 7 )   OS93 - 5   2016.12( ISSN:1344-6703

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  • 左半腹臥位胸腔鏡下食道切除術における縦隔郭清手技 Reviewed

    豊川 貴弘, 久保 尚士, 田村 達郎, 渋谷 雅常, 櫻井 克宜, 山添 定明, 木村 健二郎, 永原 央, 天野 良亮, 田中 浩明, 六車 一哉, 八代 正和, 前田 清, 平川 弘聖, 大平 雅一

    (一社)日本内視鏡外科学会, 日本内視鏡外科学会雑誌   21 ( 7 )   OS23 - 3   2016.12( ISSN:1344-6703

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  • 癌宿主因子における予後および効果予測 Reviewed

    後藤 航, 柏木 伸一郎, 浅野 有香, 渋谷 雅常, 木村 健二郎, 豊川 貴弘, 天野 良亮, 田中 浩明, 六車 一哉, 高島 勉, 八代 正和, 小野田 尚佳, 前田 清, 平川 弘聖, 大平 雅一

    大道学館出版部, 臨牀と研究   93 ( 12 )   1614 - 1615   2016.12( ISSN:0021-4965

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    癌宿主因子における炎症指標の有用性について検証した。グラスゴー予後予測スコアはCRP値とアルブミン値によって算出されるが、その他の指標はそれぞれの因子の絶対値の組み合わせで求められる。カットオフ値はROC解析で求めることが多く、評価項目は全生存期間または無病生存期間に関連して測定されることが多い。すべての指標において基準とされる数値は存在しない。末梢血から求められる炎症反応や栄養状態、免疫環境などの宿主因子は、有用な予後および治療効果予測因子である可能性が示唆された。

  • VATSによる食道亜全摘後の感染性合併症予測におけるCRPの意義

    三木 友一朗, 豊川 貴弘, 久保 尚士, 櫻井 克宣, 田村 達郎, 田中 浩明, 六車 一哉, 八代 正和, 平川 弘聖, 大平 雅一

    日本内視鏡外科学会雑誌   21 ( 7 )   OS93 - 5   2016.12( ISSN:1344-6703

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  • 左半腹臥位胸腔鏡下食道切除術における縦隔郭清手技

    豊川 貴弘, 久保 尚士, 田村 達郎, 渋谷 雅常, 櫻井 克宜, 山添 定明, 木村 健二郎, 永原 央, 天野 良亮, 田中 浩明, 六車 一哉, 八代 正和, 前田 清, 平川 弘聖, 大平 雅一

    日本内視鏡外科学会雑誌   21 ( 7 )   OS23 - 3   2016.12( ISSN:1344-6703

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  • 癌宿主因子における予後および効果予測

    後藤 航, 柏木 伸一郎, 浅野 有香, 渋谷 雅常, 木村 健二郎, 豊川 貴弘, 天野 良亮, 田中 浩明, 六車 一哉, 高島 勉, 八代 正和, 小野田 尚佳, 前田 清, 平川 弘聖, 大平 雅一

    臨牀と研究   93 ( 12 )   1614 - 1615   2016.12( ISSN:0021-4965

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    癌宿主因子における炎症指標の有用性について検証した。グラスゴー予後予測スコアはCRP値とアルブミン値によって算出されるが、その他の指標はそれぞれの因子の絶対値の組み合わせで求められる。カットオフ値はROC解析で求めることが多く、評価項目は全生存期間または無病生存期間に関連して測定されることが多い。すべての指標において基準とされる数値は存在しない。末梢血から求められる炎症反応や栄養状態、免疫環境などの宿主因子は、有用な予後および治療効果予測因子である可能性が示唆された。

  • Identification of the novel molecules mediating gastric cancer invasion based on genomic analysis of cancer-associated fibroblasts

    T. Ishimoto, K. Miyake, T. Nandi, M. Yashiro, K. K. Huang, K. Arima, D. Izumi, Y. Baba, H. Baba, P. Tan

    ANNALS OF ONCOLOGY   27   2016.12( ISSN:0923-7534 ( eISSN:1569-8041

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  • レゴラフェニブにて18ヵ月間の長期PRが得られた大腸癌肺転移の1例 Reviewed

    井関 康仁, 八代 正和, 渋谷 雅常, 永原 央, 前田 清, 松谷 慎治, 田村 達郎, 大平 豪, 山添 定明, 木村 健二郎, 豊川 貴弘, 天野 良亮, 田中 浩明, 六車 一哉, 平川 弘聖, 大平 雅一

    (株)癌と化学療法社, 癌と化学療法   43 ( 12 )   2338 - 2340   2016.11( ISSN:0385-0684

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    症例は66歳、女性。2005年12月、当科にてS状結腸癌に対してS状結腸切除術を施行。病理結果にてpT2N0M0、fStage Iであり、術後補助化学療法は施行せず経過観察していた。2011年11月にCEA 9.7ng/mLと上昇を認め、精査にて転移性肺癌を認めた。FOLFOX+bevacizumab(BV)療法を21コース、FOLFIRI+BV療法を6コース、XELOX+BV療法を13コース施行した。いずれのレジメンもprogressive disease(PD)となったため、fourth-lineとしてレゴラフェニブ療法を開始した。レゴラフェニブ開始前のレジメンにて手足症候群がみられたため、80mg/dayで開始した、Grade 2以上の副作用はでることなく投与開始後18ヵ月経過し、長期間partial response(PR)が持続し現在22コース施行中である。大腸癌肺転移再発症例に対してレゴラフェニブ投与により長期にわたるPRを得ることができた1例を経験した。(著者抄録)

  • レゴラフェニブにて18ヵ月間の長期PRが得られた大腸癌肺転移の1例

    井関 康仁, 八代 正和, 渋谷 雅常, 永原 央, 前田 清, 松谷 慎治, 田村 達郎, 大平 豪, 山添 定明, 木村 健二郎, 豊川 貴弘, 天野 良亮, 田中 浩明, 六車 一哉, 平川 弘聖, 大平 雅一

    癌と化学療法   43 ( 12 )   2338 - 2340   2016.11( ISSN:0385-0684

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    症例は66歳、女性。2005年12月、当科にてS状結腸癌に対してS状結腸切除術を施行。病理結果にてpT2N0M0、fStage Iであり、術後補助化学療法は施行せず経過観察していた。2011年11月にCEA 9.7ng/mLと上昇を認め、精査にて転移性肺癌を認めた。FOLFOX+bevacizumab(BV)療法を21コース、FOLFIRI+BV療法を6コース、XELOX+BV療法を13コース施行した。いずれのレジメンもprogressive disease(PD)となったため、fourth-lineとしてレゴラフェニブ療法を開始した。レゴラフェニブ開始前のレジメンにて手足症候群がみられたため、80mg/dayで開始した、Grade 2以上の副作用はでることなく投与開始後18ヵ月経過し、長期間partial response(PR)が持続し現在22コース施行中である。大腸癌肺転移再発症例に対してレゴラフェニブ投与により長期にわたるPRを得ることができた1例を経験した。(著者抄録)

  • Cancer Associated Fibroblasts(CAFs)ゲノム解析に基づいた胃癌浸潤を制御する新規遺伝子の同定 Reviewed

    石本 崇胤, 三宅 慧輔, 八代 正和, 有馬 浩太, 泉 大輔, 澤山 浩, 岩槻 政晃, 馬場 祥史, 坂本 快郎, 吉田 直矢, 平川 弘聖, 馬場 秀夫, Tan Patrick

    日本癌学会, 日本癌学会総会記事   75回   E - 2072   2016.10( ISSN:0546-0476

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  • スキルス胃癌微小環境における癌関連線維芽細胞由来細胞外小胞の機能解析 Reviewed

    内藤 寛, 八代 正和, 清野 透, 平川 弘聖, 勝田 毅, 安井 弥, 落谷 孝広

    日本癌学会, 日本癌学会総会記事   75回   J - 2071   2016.10( ISSN:0546-0476

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  • 乏突起膠細胞は膠芽腫細胞の浸潤を促進する Reviewed

    川嶋 俊幸, 八代 正和, 笠島 裕明, 川上 太一郎, 宇田 武弘, 中条 公輔, 渡部 祐輔, 大平 雅一, 大畑 建治

    日本癌学会, 日本癌学会総会記事   75回   P - 1089   2016.10( ISSN:0546-0476

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  • 胃 胃がんにおける予後予測因子の探索 胃癌患者における血中循環腫瘍細胞(CTC)の同定と臨床的意義 Reviewed

    三木 友一朗, 八代 正和, 増田 剛, 笠島 裕明, 北山 紀州, 奥野 倫久, 櫻井 克宣, 豊川 貴弘, 久保 尚士, 田中 浩明, 六車 一哉, 平川 弘聖, 大平 雅一

    (一社)日本癌治療学会, 日本癌治療学会学術集会抄録集   54回   MS26 - 2   2016.10

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  • 直腸切断術におけるSSIならびに骨盤内膿瘍の検討 Reviewed

    永原 央, 前田 清, 渋谷 雅常, 大谷 博, 井関 康仁, 松谷 慎治, 中尾 重富, 大平 豪, 田村 達郎, 山添 定明, 木村 健二郎, 豊川 貴弘, 天野 良亮, 田中 浩明, 六車 一哉, 八代 正和, 平川 弘聖, 大平 雅一

    (一社)日本大腸肛門病学会, 日本大腸肛門病学会雑誌   69 ( 抄録号 )   A259 - A259   2016.10( ISSN:0047-1801

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  • 残胃癌に対するリンパ節郭清は? 幽門側胃切除術後の残胃癌におけるリンパ節転移と至適郭清範囲の検討 Reviewed

    豊川 貴弘, 六車 一哉, 田村 達郎, 渋谷 雅常, 櫻井 克宜, 山添 定明, 木村 健二郎, 永原 央, 天野 良亮, 久保 尚士, 田中 浩明, 八代 正和, 前田 清, 平川 弘聖, 大平 雅一

    日本臨床外科学会, 日本臨床外科学会雑誌   77 ( 増刊 )   388 - 388   2016.10( ISSN:1345-2843

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    DOI: 10.3919/jjsa.77.388

  • 横行結腸癌術後Sister Mary Joseph's noduleの1例 Reviewed

    伊藤 厳太郎, 竹内 麦穂, 狭間 研至, 大澤 尚志, 永原 央, 久保 尚士, 八代 正和, 大平 雅一

    日本臨床外科学会, 日本臨床外科学会雑誌   77 ( 増刊 )   943 - 943   2016.10( ISSN:1345-2843

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    DOI: 10.3919/jjsa.77.943

  • 大腸 直腸がん手術療法の多様な視点 直腸癌における腹腔鏡手術の長期成績 Reviewed

    永原 央, 前田 清, 渋谷 雅常, 大谷 博, 中尾 重富, 井関 康仁, 松谷 慎治, 木村 健二郎, 豊川 貴弘, 天野 良亮, 田中 浩明, 六車 一哉, 八代 正和, 平川 弘聖, 大平 雅一

    (一社)日本癌治療学会, 日本癌治療学会学術集会抄録集   54回   WS28 - 4   2016.10

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  • 低酸素環境における胃癌細胞の糖代謝関連酵素の細胞増殖に関する検討 Reviewed

    北山 紀州, 八代 正和, 森崎 珠実, 木下 春人, 笠島 裕明, 増田 剛, 三木 友一朗, 奥野 倫久, 平川 弘聖, 大平 雅一

    日本癌学会, 日本癌学会総会記事   75回   P - 2141   2016.10( ISSN:0546-0476

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  • 胃癌患者におけるStamp細胞診の有用性 Reviewed

    三木 友一朗, 八代 正和, 増田 剛, 笠島 裕明, 北山 紀州, 奥野 倫久, 櫻井 克宣, 豊川 貴弘, 久保 尚士, 田中 浩明, 六車 一哉, 平川 弘聖, 大平 雅一

    日本癌学会, 日本癌学会総会記事   75回   P - 1198   2016.10( ISSN:0546-0476

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  • 高齢胃癌患者の術前筋肉量と治療成績の関連 Reviewed

    櫻井 克宣, 田村 達郎, 豊川 貴弘, 天野 良亮, 田中 浩明, 六車 一哉, 前田 清, 八代 正和, 玉森 豊, 久保 尚士, 西口 幸雄, 平川 弘聖, 大平 雅一

    日本臨床外科学会, 日本臨床外科学会雑誌   77 ( 増刊 )   463 - 463   2016.10( ISSN:1345-2843

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    DOI: 10.3919/jjsa.77.463

  • 進行・再発胃癌における一次治療としてのG-SOX療法の安全性と有用性 Reviewed

    豊川 貴弘, 六車 一哉, 田村 達郎, 渋谷 雅常, 櫻井 克宜, 山添 定明, 木村 健二郎, 永原 央, 天野 良亮, 久保 尚士, 田中 浩明, 八代 正和, 前田 清, 平川 弘聖, 大平 雅一

    (一社)日本癌治療学会, 日本癌治療学会学術集会抄録集   54回   P32 - 4   2016.10

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  • 術前高度心機能低下を呈した肝浸潤を伴う悪性褐色細胞腫に対して肝右葉切除を併施し、安全に切除し得た1例 Reviewed

    辻尾 元, 木村 健二郎, 田内 幸枝, 大平 豪, 天野 良亮, 山添 定明, 豊川 貴弘, 田中 浩明, 六車 一哉, 高島 勉, 八代 正和, 小野田 尚佳, 前田 清, 平川 弘聖, 大平 雅一

    日本臨床外科学会, 日本臨床外科学会雑誌   77 ( 増刊 )   891 - 891   2016.10( ISSN:1345-2843

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    DOI: 10.3919/jjsa.77.891

  • 術前分割DCF療法によって病理学的完全奏効を得た胸部食道癌の1例 Reviewed

    福井 康裕, 豊川 貴弘, 笠島 裕明, 田村 達郎, 天野 良亮, 田中 浩明, 六車 一哉, 八代 正和, 前田 清, 平川 弘聖, 大平 雅一

    日本臨床外科学会, 日本臨床外科学会雑誌   77 ( 増刊 )   863 - 863   2016.10( ISSN:1345-2843

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    DOI: 10.3919/jjsa.77.863

  • Cancer Associated Fibroblasts(CAFs)ゲノム解析に基づいた胃癌浸潤を制御する新規遺伝子の同定

    石本 崇胤, 三宅 慧輔, 八代 正和, 有馬 浩太, 泉 大輔, 澤山 浩, 岩槻 政晃, 馬場 祥史, 坂本 快郎, 吉田 直矢, 平川 弘聖, 馬場 秀夫, Tan Patrick

    日本癌学会総会記事   75回   E - 2072   2016.10( ISSN:0546-0476

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  • 高齢胃癌患者の術前筋肉量と治療成績の関連

    櫻井 克宣, 田村 達郎, 豊川 貴弘, 天野 良亮, 田中 浩明, 六車 一哉, 前田 清, 八代 正和, 玉森 豊, 久保 尚士, 西口 幸雄, 平川 弘聖, 大平 雅一

    日本臨床外科学会雑誌   77 ( 増刊 )   463 - 463   2016.10( ISSN:1345-2843

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    DOI: 10.3919/jjsa.77.463

  • スキルス胃癌微小環境における癌関連線維芽細胞由来細胞外小胞の機能解析

    内藤 寛, 八代 正和, 清野 透, 平川 弘聖, 勝田 毅, 安井 弥, 落谷 孝広

    日本癌学会総会記事   75回   J - 2071   2016.10( ISSN:0546-0476

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  • 胃 胃がんにおける予後予測因子の探索 胃癌患者における血中循環腫瘍細胞(CTC)の同定と臨床的意義

    三木 友一朗, 八代 正和, 増田 剛, 笠島 裕明, 北山 紀州, 奥野 倫久, 櫻井 克宣, 豊川 貴弘, 久保 尚士, 田中 浩明, 六車 一哉, 平川 弘聖, 大平 雅一

    日本癌治療学会学術集会抄録集   54回   MS26 - 2   2016.10

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  • 直腸切断術におけるSSIならびに骨盤内膿瘍の検討

    永原 央, 前田 清, 渋谷 雅常, 大谷 博, 井関 康仁, 松谷 慎治, 中尾 重富, 大平 豪, 田村 達郎, 山添 定明, 木村 健二郎, 豊川 貴弘, 天野 良亮, 田中 浩明, 六車 一哉, 八代 正和, 平川 弘聖, 大平 雅一

    日本大腸肛門病学会雑誌   69 ( 抄録号 )   A259 - A259   2016.10( ISSN:0047-1801

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  • 残胃癌に対するリンパ節郭清は? 幽門側胃切除術後の残胃癌におけるリンパ節転移と至適郭清範囲の検討

    豊川 貴弘, 六車 一哉, 田村 達郎, 渋谷 雅常, 櫻井 克宜, 山添 定明, 木村 健二郎, 永原 央, 天野 良亮, 久保 尚士, 田中 浩明, 八代 正和, 前田 清, 平川 弘聖, 大平 雅一

    日本臨床外科学会雑誌   77 ( 増刊 )   388 - 388   2016.10( ISSN:1345-2843

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    DOI: 10.3919/jjsa.77.388

  • 横行結腸癌術後Sister Mary Joseph's noduleの1例

    伊藤 厳太郎, 竹内 麦穂, 狭間 研至, 大澤 尚志, 永原 央, 久保 尚士, 八代 正和, 大平 雅一

    日本臨床外科学会雑誌   77 ( 増刊 )   943 - 943   2016.10( ISSN:1345-2843

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    DOI: 10.3919/jjsa.77.943

  • 大腸 直腸がん手術療法の多様な視点 直腸癌における腹腔鏡手術の長期成績

    永原 央, 前田 清, 渋谷 雅常, 大谷 博, 中尾 重富, 井関 康仁, 松谷 慎治, 木村 健二郎, 豊川 貴弘, 天野 良亮, 田中 浩明, 六車 一哉, 八代 正和, 平川 弘聖, 大平 雅一

    日本癌治療学会学術集会抄録集   54回   WS28 - 4   2016.10

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  • 低酸素環境における胃癌細胞の糖代謝関連酵素の細胞増殖に関する検討

    北山 紀州, 八代 正和, 森崎 珠実, 木下 春人, 笠島 裕明, 増田 剛, 三木 友一朗, 奥野 倫久, 平川 弘聖, 大平 雅一

    日本癌学会総会記事   75回   P - 2141   2016.10( ISSN:0546-0476

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  • 乏突起膠細胞は膠芽腫細胞の浸潤を促進する

    川嶋 俊幸, 八代 正和, 笠島 裕明, 川上 太一郎, 宇田 武弘, 中条 公輔, 渡部 祐輔, 大平 雅一, 大畑 建治

    日本癌学会総会記事   75回   P - 1089   2016.10( ISSN:0546-0476

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  • 胃癌患者におけるStamp細胞診の有用性

    三木 友一朗, 八代 正和, 増田 剛, 笠島 裕明, 北山 紀州, 奥野 倫久, 櫻井 克宣, 豊川 貴弘, 久保 尚士, 田中 浩明, 六車 一哉, 平川 弘聖, 大平 雅一

    日本癌学会総会記事   75回   P - 1198   2016.10( ISSN:0546-0476

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  • 進行・再発胃癌における一次治療としてのG-SOX療法の安全性と有用性

    豊川 貴弘, 六車 一哉, 田村 達郎, 渋谷 雅常, 櫻井 克宜, 山添 定明, 木村 健二郎, 永原 央, 天野 良亮, 久保 尚士, 田中 浩明, 八代 正和, 前田 清, 平川 弘聖, 大平 雅一

    日本癌治療学会学術集会抄録集   54回   P32 - 4   2016.10

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  • 術前高度心機能低下を呈した肝浸潤を伴う悪性褐色細胞腫に対して肝右葉切除を併施し、安全に切除し得た1例

    辻尾 元, 木村 健二郎, 田内 幸枝, 大平 豪, 天野 良亮, 山添 定明, 豊川 貴弘, 田中 浩明, 六車 一哉, 高島 勉, 八代 正和, 小野田 尚佳, 前田 清, 平川 弘聖, 大平 雅一

    日本臨床外科学会雑誌   77 ( 増刊 )   891 - 891   2016.10( ISSN:1345-2843 ( eISSN:1882-5133

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    DOI: 10.3919/jjsa.77.891

  • 術前分割DCF療法によって病理学的完全奏効を得た胸部食道癌の1例

    福井 康裕, 豊川 貴弘, 笠島 裕明, 田村 達郎, 天野 良亮, 田中 浩明, 六車 一哉, 八代 正和, 前田 清, 平川 弘聖, 大平 雅一

    日本臨床外科学会雑誌   77 ( 増刊 )   863 - 863   2016.10( ISSN:1345-2843

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    Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

    DOI: 10.3919/jjsa.77.863

  • 分子腫瘍マーカー診療ガイドラインとそのエビデンス 胃癌診療における腫瘍マーカー Reviewed

    八代 正和

    日本分子腫瘍マーカー研究会, 日本分子腫瘍マーカー研究会プログラム・講演抄録   36回   30 - 30   2016.09

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  • 癌微小環境における胃癌細胞の糖代謝関連酵素(PKM2、ENO1、GLS)の意義 Reviewed

    北山 紀州, 八代 正和, 森崎 珠実, 奥野 倫久, 三木 友一朗, 笠島 裕明, 増田 剛, 豊川 貴弘, 田中 浩明, 六車 一哉, 平川 弘聖, 大平 雅一

    日本分子腫瘍マーカー研究会, 日本分子腫瘍マーカー研究会プログラム・講演抄録   36回   78 - 79   2016.09

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    Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 腹腔鏡下に整復しえた胃癌術後の内ヘルニア Reviewed

    福井 康裕, 笠島 裕明, 田村 達郎, 豊川 貴弘, 天野 良亮, 田中 浩明, 六車 一哉, 八代 正和, 前田 清, 平川 弘聖, 大平 雅一

    日本Acute Care Surgery学会, Japanese Journal of Acute Care Surgery   6 ( 2 )   233 - 233   2016.09

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    Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 膵頭部癌化学放射線療法中に留置膵管ステントにより膵管破裂を発症した1例 Reviewed

    森 拓哉, 大平 豪, 木村 健二郎, 天野 良亮, 山添 定明, 八代 正和, 小野田 尚佳, 前田 清, 平川 弘聖, 大平 雅一

    日本Acute Care Surgery学会, Japanese Journal of Acute Care Surgery   6 ( 2 )   202 - 202   2016.09

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    Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 分子腫瘍マーカー診療ガイドラインとそのエビデンス 胃癌診療における腫瘍マーカー

    八代 正和

    日本分子腫瘍マーカー研究会プログラム・講演抄録   36回   30 - 30   2016.09

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    Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 癌微小環境における胃癌細胞の糖代謝関連酵素(PKM2、ENO1、GLS)の意義

    北山 紀州, 八代 正和, 森崎 珠実, 奥野 倫久, 三木 友一朗, 笠島 裕明, 増田 剛, 豊川 貴弘, 田中 浩明, 六車 一哉, 平川 弘聖, 大平 雅一

    日本分子腫瘍マーカー研究会プログラム・講演抄録   36回   78 - 79   2016.09

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    Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 腹腔鏡下に整復しえた胃癌術後の内ヘルニア

    福井 康裕, 笠島 裕明, 田村 達郎, 豊川 貴弘, 天野 良亮, 田中 浩明, 六車 一哉, 八代 正和, 前田 清, 平川 弘聖, 大平 雅一

    Japanese Journal of Acute Care Surgery   6 ( 2 )   233 - 233   2016.09

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    Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 膵頭部癌化学放射線療法中に留置膵管ステントにより膵管破裂を発症した1例

    森 拓哉, 大平 豪, 木村 健二郎, 天野 良亮, 山添 定明, 八代 正和, 小野田 尚佳, 前田 清, 平川 弘聖, 大平 雅一

    Japanese Journal of Acute Care Surgery   6 ( 2 )   202 - 202   2016.09

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  • Cancer Associated Fibroblastsゲノム解析に基づいたdiffuse type胃癌浸潤を制御する新規遺伝子の同定 Reviewed

    石本 崇胤, 三宅 慧輔, 八代 正和, 泉 大輔, 有馬 浩太, 馬場 祥史, 渡邊 雅之, 平川 弘聖, Patrick Tan, 馬場 秀夫

    (一社)日本消化器外科学会, 日本消化器外科学会総会   71回   P1 - 12   2016.07

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    Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 低酸素環境における胃癌細胞の糖代謝関連酵素の意義 Reviewed

    北山 紀州, 八代 正和, 森崎 珠実, 増田 剛, 笠島 裕明, 三木 友一朗, 木下 春人, 福岡 達成, 大平 雅一, 平川 弘聖

    (一社)日本消化器外科学会, 日本消化器外科学会総会   71回   P2 - 13   2016.07

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    Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 胃癌周囲微小環境におけるエクソソームの臨床的意義 Reviewed

    三木 友一朗, 八代 正和, 北山 紀州, 笠島 裕明, 増田 剛, 久保 尚士, 田中 浩明, 六車 一哉, 大平 雅一, 平川 弘聖

    (一社)日本消化器外科学会, 日本消化器外科学会総会   71回   P2 - 14   2016.07

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  • 胃癌におけるFGFR2-IIIb、IIIc発現の臨床病理学的検討 Reviewed

    増田 剛, 八代 正和, 三木 友一朗, 北山 紀州, 笠島 裕明, 久保 尚士, 田中 浩明, 六車 一哉, 大平 雅一, 平川 弘聖

    (一社)日本消化器外科学会, 日本消化器外科学会総会   71回   P2 - 14   2016.07

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  • 胃切除後食道癌に対する血管吻合付加空腸再建の有用性 大腸再建と比較して Reviewed

    久保 尚士, 田村 達郎, 櫻井 克宣, 豊川 貴弘, 田中 浩明, 六車 一哉, 八代 正和, 山下 好人, 大平 雅一, 平川 弘聖

    (一社)日本消化器外科学会, 日本消化器外科学会総会   71回   P2 - 6   2016.07

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  • 所属リンパ節にサルコイド反応を認めたESD適応食道表在癌の一例 Reviewed

    登 千穂子, 櫻井 克宜, 田村 達郎, 豊川 貴弘, 久保 尚士, 田中 浩明, 六車 一哉, 八代 正和, 大平 雅一, 平川 弘聖

    (NPO)日本食道学会, 日本食道学会学術集会プログラム・抄録集   70回   168 - 168   2016.07

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  • 切除可能胸部食道癌における治療前予後因子としてのCONUT scoreの意義 Reviewed

    豊川 貴弘, 久保 尚士, 大平 雅一, 田村 達郎, 櫻井 克宜, 田中 浩明, 六車 一哉, 八代 正和, 前田 清, 平川 弘聖

    (NPO)日本食道学会, 日本食道学会学術集会プログラム・抄録集   70回   184 - 184   2016.07

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  • 胃癌患者におけるサルコペニアと術後合併症の関連 Reviewed

    田村 達郎, 櫻井 克宣, 六車 一哉, 豊川 貴弘, 久保 尚士, 田中 浩明, 八代 正和, 前田 清, 大平 雅一, 平川 弘聖

    (一社)日本消化器外科学会, 日本消化器外科学会総会   71回   P1 - 20   2016.07

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  • 高齢胃癌患者の術前体重が術後成績に与える影響についての検討 Reviewed

    櫻井 克宣, 田村 達郎, 豊川 貴弘, 久保 尚士, 田中 浩明, 六車 一哉, 八代 正和, 前田 清, 大平 雅一, 平川 弘聖

    (一社)日本消化器外科学会, 日本消化器外科学会総会   71回   P1 - 25   2016.07

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  • 高齢者大腸癌における腹腔鏡手術 Reviewed

    永原 央, 前田 清, 渋谷 雅常, 天野 良亮, 久保 尚士, 田中 浩明, 六車 一哉, 八代 正和, 大平 雅一, 平川 弘聖

    (一社)日本消化器外科学会, 日本消化器外科学会総会   71回   P1 - 41   2016.07

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  • 食道癌患者の術前筋肉量の低下と術後合併症の検討 Reviewed

    櫻井 克宣, 田村 達郎, 豊川 貴弘, 久保 尚士, 田中 浩明, 六車 一哉, 八代 正和, 前田 清, 大平 雅一, 平川 弘聖

    (NPO)日本食道学会, 日本食道学会学術集会プログラム・抄録集   70回   126 - 126   2016.07

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  • 表在食道癌6病変に対するESD後、所属リンパ節にサルコイド反応を伴い、リンパ節転移と鑑別を要した一例 Reviewed

    登 千穂子, 櫻井 克宜, 田村 達郎, 豊川 貴弘, 久保 尚士, 田中 浩明, 六車 一哉, 八代 正和, 大平 雅一, 平川 弘聖

    (一社)日本消化器外科学会, 日本消化器外科学会総会   71回   P2 - 10   2016.07

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  • 高齢胃癌患者の術前体重が術後成績に与える影響についての検討

    櫻井 克宣, 田村 達郎, 豊川 貴弘, 久保 尚士, 田中 浩明, 六車 一哉, 八代 正和, 前田 清, 大平 雅一, 平川 弘聖

    日本消化器外科学会総会   71回   P1 - 25   2016.07

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    Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • Cancer Associated Fibroblastsゲノム解析に基づいたdiffuse type胃癌浸潤を制御する新規遺伝子の同定

    石本 崇胤, 三宅 慧輔, 八代 正和, 泉 大輔, 有馬 浩太, 馬場 祥史, 渡邊 雅之, 平川 弘聖, Patrick Tan, 馬場 秀夫

    日本消化器外科学会総会   71回   P1 - 12   2016.07

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  • 低酸素環境における胃癌細胞の糖代謝関連酵素の意義

    北山 紀州, 八代 正和, 森崎 珠実, 増田 剛, 笠島 裕明, 三木 友一朗, 木下 春人, 福岡 達成, 大平 雅一, 平川 弘聖

    日本消化器外科学会総会   71回   P2 - 13   2016.07

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  • 胃癌におけるFGFR2-IIIb、IIIc発現の臨床病理学的検討

    増田 剛, 八代 正和, 三木 友一朗, 北山 紀州, 笠島 裕明, 久保 尚士, 田中 浩明, 六車 一哉, 大平 雅一, 平川 弘聖

    日本消化器外科学会総会   71回   P2 - 14   2016.07

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  • 胃切除後食道癌に対する血管吻合付加空腸再建の有用性 大腸再建と比較して

    久保 尚士, 田村 達郎, 櫻井 克宣, 豊川 貴弘, 田中 浩明, 六車 一哉, 八代 正和, 山下 好人, 大平 雅一, 平川 弘聖

    日本消化器外科学会総会   71回   P2 - 6   2016.07

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  • 所属リンパ節にサルコイド反応を認めたESD適応食道表在癌の一例

    登 千穂子, 櫻井 克宜, 田村 達郎, 豊川 貴弘, 久保 尚士, 田中 浩明, 六車 一哉, 八代 正和, 大平 雅一, 平川 弘聖

    日本食道学会学術集会プログラム・抄録集   70回   168 - 168   2016.07

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    Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 切除可能胸部食道癌における治療前予後因子としてのCONUT scoreの意義

    豊川 貴弘, 久保 尚士, 大平 雅一, 田村 達郎, 櫻井 克宜, 田中 浩明, 六車 一哉, 八代 正和, 前田 清, 平川 弘聖

    日本食道学会学術集会プログラム・抄録集   70回   184 - 184   2016.07

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    Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 胃癌周囲微小環境におけるエクソソームの臨床的意義

    三木 友一朗, 八代 正和, 北山 紀州, 笠島 裕明, 増田 剛, 久保 尚士, 田中 浩明, 六車 一哉, 大平 雅一, 平川 弘聖

    日本消化器外科学会総会   71回   P2 - 14   2016.07

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    Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 高齢者大腸癌における腹腔鏡手術

    永原 央, 前田 清, 渋谷 雅常, 天野 良亮, 久保 尚士, 田中 浩明, 六車 一哉, 八代 正和, 大平 雅一, 平川 弘聖

    日本消化器外科学会総会   71回   P1 - 41   2016.07

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    Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 食道癌患者の術前筋肉量の低下と術後合併症の検討

    櫻井 克宣, 田村 達郎, 豊川 貴弘, 久保 尚士, 田中 浩明, 六車 一哉, 八代 正和, 前田 清, 大平 雅一, 平川 弘聖

    日本食道学会学術集会プログラム・抄録集   70回   126 - 126   2016.07

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    Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 表在食道癌6病変に対するESD後、所属リンパ節にサルコイド反応を伴い、リンパ節転移と鑑別を要した一例

    登 千穂子, 櫻井 克宜, 田村 達郎, 豊川 貴弘, 久保 尚士, 田中 浩明, 六車 一哉, 八代 正和, 大平 雅一, 平川 弘聖

    日本消化器外科学会総会   71回   P2 - 10   2016.07

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  • 胃癌患者におけるサルコペニアと術後合併症の関連

    田村 達郎, 櫻井 克宣, 六車 一哉, 豊川 貴弘, 久保 尚士, 田中 浩明, 八代 正和, 前田 清, 大平 雅一, 平川 弘聖

    日本消化器外科学会総会   71回   P1 - 20   2016.07

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  • Cancer stem cells might sustain sternness by the induction of autophagy in starvation stress

    Go Masuda, Masakazu Yashiro, Kishu Kitayama, Yuichiro Miki, Hiroaki Kasashima, Tamami Morisaki, Tatsunari Fukuoka, Tsuyoshi Hasegawa, Masaichi Ohira, Kosei Hirakawa

    CANCER RESEARCH   76   2016.07( ISSN:0008-5472 ( eISSN:1538-7445

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    Publishing type:Research paper, summary (international conference)  

    DOI: 10.1158/1538-7445.AM2016-1730

  • Significance of glypican-1 expression on tumor stromal cells in gastric carcinoma

    Yuichiro Miki, Masakazu Yashiro, Kishu Kitayama, Hiroaki Kasashima, Go Masuda, Naoshi Kubo, Katsunobu Sakurai, Takahiro Toyokawa, Hiroaki Tanaka, Kazuya Muguruma, Masaichi Ohira, Kosei Hirakawa

    CANCER RESEARCH   76   2016.07( ISSN:0008-5472 ( eISSN:1538-7445

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    DOI: 10.1158/1538-7445.AM2016-4097

  • Prostaglandin D synthase is a potential novel therapeutic agent for the treatment of gastric carcinomas expressing PPAR gamma

    Masakazu Yashiro, Tatsunari Fukuoka, Haruhito Kinoshita, Go Masuda, Kishu Kitayama, Yuichiro Miki, Tamami Morisaki, Tsuyoshi Hasegawa, Kosei Hirakawa

    CANCER RESEARCH   76   2016.07( ISSN:0008-5472 ( eISSN:1538-7445

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    DOI: 10.1158/1538-7445.AM2016-1281

  • Effect of glucose metabolism-related enzymes on the proliferation of gastric cancer cells in hypoxic microenvironment

    Kishu Kitayama, Masakazu Yashiro, Tamami Morisaki, Go Masuda, Hiroakai Kasashima, Yuichiro Miki, Haruhito Kinoshita, Tastunari Fukuoka, Tsuyoshi Hasegawa, Masaichi Ohira, Kosei Hirakawa

    CANCER RESEARCH   76   2016.07( ISSN:0008-5472 ( eISSN:1538-7445

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    DOI: 10.1158/1538-7445.AM2016-37

  • 高齢胃癌患者の術前栄養と長期予後の関係 Reviewed

    櫻井 克宣, 田村 達郎, 渋谷 雅常, 山添 定明, 永原 央, 木村 健二郎, 豊川 貴弘, 天野 良亮, 久保 尚士, 田中 浩明, 六車 一哉, 八代 正和, 前田 清, 大平 雅一, 平川 弘聖

    日本外科系連合学会, 日本外科系連合学会誌   41 ( 3 )   517 - 517   2016.05( ISSN:0385-7883

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  • 高齢胃癌患者の術前栄養と長期予後の関係

    櫻井 克宣, 田村 達郎, 渋谷 雅常, 山添 定明, 永原 央, 木村 健二郎, 豊川 貴弘, 天野 良亮, 久保 尚士, 田中 浩明, 六車 一哉, 八代 正和, 前田 清, 大平 雅一, 平川 弘聖

    日本外科系連合学会誌   41 ( 3 )   517 - 517   2016.05( ISSN:0385-7883

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  • ストレス状態癌幹細胞におけるオートファジーの意義 Reviewed

    増田 剛, 八代 正和, 北山 紀州, 笠島 裕明, 三木 友一郎, 木下 春人, 福岡 達成, 森崎 珠美, 平川 弘聖

    (一社)日本外科学会, 日本外科学会定期学術集会抄録集   116回   OP - 045   2016.04

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    Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 切除可能胸部食道癌における予後因子としての免疫栄養指標の意義 Reviewed

    豊川 貴弘, 久保 尚士, 大平 雅一, 田村 達郎, 大平 豪, 櫻井 克宜, 渋谷 雅常, 山添 定明, 木村 健二郎, 永原 央, 天野 良亮, 田中 浩明, 六車 一哉, 八代 正和, 前田 清, 平川 弘聖

    (一社)日本外科学会, 日本外科学会定期学術集会抄録集   116回   PS - 034   2016.04

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  • 胃癌微小環境における間質酵素Lysy Oxidase(LOX)familyのバイオマーカーとしての意義とその機能解析 Reviewed

    笠島 裕明, 八代 正和, 三木 友一朗, 北山 紀州, 増田 剛, 櫻井 克宣, 豊川 貴弘, 久保 尚士, 田中 浩明, 六車 一哉, 大平 雅一, 平川 弘聖

    (一社)日本外科学会, 日本外科学会定期学術集会抄録集   116回   OP - 015   2016.04

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  • 胃癌における腫瘍浸潤B細胞と臨床病理学的因子との関係 Reviewed

    崎村 千恵, 田中 浩明, 田内 幸枝, 徳本 真央, 田村 達郎, 櫻井 克宣, 豊川 貴弘, 久保 尚士, 山添 定明, 木村 健二郎, 天野 良亮, 六車 一哉, 八代 正和, 前田 清, 大平 雅一, 平川 弘聖

    (一社)日本外科学会, 日本外科学会定期学術集会抄録集   116回   OP - 016   2016.04

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  • 胃切除が体組成に及ぼす影響に関する検討 Reviewed

    櫻井 克宣, 田村 達郎, 大平 豪, 渋谷 雅常, 山添 定明, 永原 央, 木村 健二郎, 豊川 貴弘, 天野 良亮, 久保 尚士, 田中 浩明, 六車 一哉, 八代 正和, 前田 清, 大平 雅一, 平川 弘聖

    (一社)日本外科学会, 日本外科学会定期学術集会抄録集   116回   PS - 044   2016.04

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    Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 肥満と直腸癌手術の関連について Reviewed

    永原 央, 前田 清, 渋谷 雅常, 大谷 博, 井関 康仁, 池谷 哲郎, 大平 豪, 田村 達郎, 櫻井 克宣, 山添 定明, 木村 健二郎, 豊川 貴弘, 天野 良亮, 久保 尚士, 田中 浩明, 六車 一哉, 八代 正和, 大平 雅一, 平川 弘聖

    (一社)日本外科学会, 日本外科学会定期学術集会抄録集   116回   PS - 136   2016.04

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    Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 網羅的ゲノム解析に基づいた胃癌Cancer Associated Fibroblasts(CAFs)の特性解明 Reviewed

    石本 崇胤, 三宅 慧輔, 八代 正和, 泉 大輔, 志垣 博信, 藏重 淳二, 岩槻 政晃, 馬場 祥史, 坂本 快郎, 宮本 裕士, 吉田 直矢, 平川 弘聖, Tan Patrick, 馬場 秀夫

    (一社)日本外科学会, 日本外科学会定期学術集会抄録集   116回   OP - 016   2016.04

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  • 糖代謝酵素が低酸素状態の胃癌細胞増殖におよぼす影響の検討 Reviewed

    北山 紀州, 八代 正和, 森崎 珠実, 木下 春人, 福岡 達成, 笠島 裕明, 増田 剛, 平川 弘聖

    (一社)日本外科学会, 日本外科学会定期学術集会抄録集   116回   PS - 028   2016.04

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    Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 尾側膵切除術における膵切離法の検討 補強シート付きstaplerの有用性 Reviewed

    大平 豪, 天野 良亮, 木村 健二郎, 山添 定明, 西尾 康平, 三浦 光太郎, 田村 達郎, 渋谷 雅常, 櫻井 克宣, 永原 央, 豊川 貴弘, 久保 尚士, 田中 浩明, 六車 一哉, 八代 正和, 前田 清, 大平 雅一, 平川 弘聖

    (一社)日本外科学会, 日本外科学会定期学術集会抄録集   116回   PS - 006   2016.04

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    Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 胃癌患者の術前栄養と術後短期QOLの関連について Reviewed

    平松 宗一郎, 櫻井 克宣, 田村 達郎, 山添 定明, 木村 健二郎, 永原 央, 豊川 貴弘, 天野 良亮, 久保 尚士, 田中 浩明, 六車 一哉, 八代 正和, 前田 清, 大平 雅一, 平川 弘聖

    (一社)日本外科学会, 日本外科学会定期学術集会抄録集   116回   PS - 044   2016.04

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    Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 食道癌患者の術前prognostic nutritional index(PNI)は術後短期長期成績に影響を及ぼすか? Reviewed

    久保 尚士, 大平 雅一, 田村 達郎, 櫻井 克宣, 豊川 貴弘, 山下 好人, 森本 純也, 玉森 豊, 田中 浩明, 六車 一哉, 大平 豪, 渋谷 雅常, 山添 定明, 永原 央, 木村 健二郎, 天野 良亮, 八代 正和, 前田 清, 平川 弘聖

    (一社)日本外科学会, 日本外科学会定期学術集会抄録集   116回   PS - 033   2016.04

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    Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 膵退形成癌におけるSP細胞の意義 Reviewed

    三浦 光太郎, 木村 健二郎, 天野 良亮, 山添 定明, 西尾 康平, 大平 豪, 澁谷 雅常, 櫻井 克宣, 永原 央, 豊川 貴弘, 久保 尚士, 田中 浩明, 六車 一哉, 八代 正和, 前田 清, 大平 雅一, 平川 弘聖

    (一社)日本外科学会, 日本外科学会定期学術集会抄録集   116回   PS - 002   2016.04

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  • 胃癌関連マクロファージのリンパ行性転移へ及ぼす影響 Reviewed

    田内 幸枝, 田中 浩明, 崎村 千恵, 徳本 真央, 田村 達郎, 櫻井 克宣, 豊川 貴弘, 久保 尚士, 山添 定明, 木村 健二郎, 天野 良亮, 六車 一哉, 八代 正和, 前田 清, 大平 雅一, 平川 弘聖

    (一社)日本外科学会, 日本外科学会定期学術集会抄録集   116回   PS - 028   2016.04

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  • ストレス状態癌幹細胞におけるオートファジーの意義

    増田 剛, 八代 正和, 北山 紀州, 笠島 裕明, 三木 友一郎, 木下 春人, 福岡 達成, 森崎 珠美, 平川 弘聖

    日本外科学会定期学術集会抄録集   116回   OP - 045   2016.04

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  • 胃切除が体組成に及ぼす影響に関する検討

    櫻井 克宣, 田村 達郎, 大平 豪, 渋谷 雅常, 山添 定明, 永原 央, 木村 健二郎, 豊川 貴弘, 天野 良亮, 久保 尚士, 田中 浩明, 六車 一哉, 八代 正和, 前田 清, 大平 雅一, 平川 弘聖

    日本外科学会定期学術集会抄録集   116回   PS - 044   2016.04

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    Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 肥満と直腸癌手術の関連について

    永原 央, 前田 清, 渋谷 雅常, 大谷 博, 井関 康仁, 池谷 哲郎, 大平 豪, 田村 達郎, 櫻井 克宣, 山添 定明, 木村 健二郎, 豊川 貴弘, 天野 良亮, 久保 尚士, 田中 浩明, 六車 一哉, 八代 正和, 大平 雅一, 平川 弘聖

    日本外科学会定期学術集会抄録集   116回   PS - 136   2016.04

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    Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 網羅的ゲノム解析に基づいた胃癌Cancer Associated Fibroblasts(CAFs)の特性解明

    石本 崇胤, 三宅 慧輔, 八代 正和, 泉 大輔, 志垣 博信, 藏重 淳二, 岩槻 政晃, 馬場 祥史, 坂本 快郎, 宮本 裕士, 吉田 直矢, 平川 弘聖, Tan Patrick, 馬場 秀夫

    日本外科学会定期学術集会抄録集   116回   OP - 016   2016.04

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    Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 糖代謝酵素が低酸素状態の胃癌細胞増殖におよぼす影響の検討

    北山 紀州, 八代 正和, 森崎 珠実, 木下 春人, 福岡 達成, 笠島 裕明, 増田 剛, 平川 弘聖

    日本外科学会定期学術集会抄録集   116回   PS - 028   2016.04

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    Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 尾側膵切除術における膵切離法の検討 補強シート付きstaplerの有用性

    大平 豪, 天野 良亮, 木村 健二郎, 山添 定明, 西尾 康平, 三浦 光太郎, 田村 達郎, 渋谷 雅常, 櫻井 克宣, 永原 央, 豊川 貴弘, 久保 尚士, 田中 浩明, 六車 一哉, 八代 正和, 前田 清, 大平 雅一, 平川 弘聖

    日本外科学会定期学術集会抄録集   116回   PS - 006   2016.04

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    Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 切除可能胸部食道癌における予後因子としての免疫栄養指標の意義

    豊川 貴弘, 久保 尚士, 大平 雅一, 田村 達郎, 大平 豪, 櫻井 克宜, 渋谷 雅常, 山添 定明, 木村 健二郎, 永原 央, 天野 良亮, 田中 浩明, 六車 一哉, 八代 正和, 前田 清, 平川 弘聖

    日本外科学会定期学術集会抄録集   116回   PS - 034   2016.04

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  • 胃癌における腫瘍浸潤B細胞と臨床病理学的因子との関係

    崎村 千恵, 田中 浩明, 田内 幸枝, 徳本 真央, 田村 達郎, 櫻井 克宣, 豊川 貴弘, 久保 尚士, 山添 定明, 木村 健二郎, 天野 良亮, 六車 一哉, 八代 正和, 前田 清, 大平 雅一, 平川 弘聖

    日本外科学会定期学術集会抄録集   116回   OP - 016   2016.04

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    Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 食道癌患者の術前prognostic nutritional index(PNI)は術後短期長期成績に影響を及ぼすか?

    久保 尚士, 大平 雅一, 田村 達郎, 櫻井 克宣, 豊川 貴弘, 山下 好人, 森本 純也, 玉森 豊, 田中 浩明, 六車 一哉, 大平 豪, 渋谷 雅常, 山添 定明, 永原 央, 木村 健二郎, 天野 良亮, 八代 正和, 前田 清, 平川 弘聖

    日本外科学会定期学術集会抄録集   116回   PS - 033   2016.04

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    Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 膵退形成癌におけるSP細胞の意義

    三浦 光太郎, 木村 健二郎, 天野 良亮, 山添 定明, 西尾 康平, 大平 豪, 澁谷 雅常, 櫻井 克宣, 永原 央, 豊川 貴弘, 久保 尚士, 田中 浩明, 六車 一哉, 八代 正和, 前田 清, 大平 雅一, 平川 弘聖

    日本外科学会定期学術集会抄録集   116回   PS - 002   2016.04

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    Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 胃癌関連マクロファージのリンパ行性転移へ及ぼす影響

    田内 幸枝, 田中 浩明, 崎村 千恵, 徳本 真央, 田村 達郎, 櫻井 克宣, 豊川 貴弘, 久保 尚士, 山添 定明, 木村 健二郎, 天野 良亮, 六車 一哉, 八代 正和, 前田 清, 大平 雅一, 平川 弘聖

    日本外科学会定期学術集会抄録集   116回   PS - 028   2016.04

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    Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 胃癌患者の術前栄養と術後短期QOLの関連について

    平松 宗一郎, 櫻井 克宣, 田村 達郎, 山添 定明, 木村 健二郎, 永原 央, 豊川 貴弘, 天野 良亮, 久保 尚士, 田中 浩明, 六車 一哉, 八代 正和, 前田 清, 大平 雅一, 平川 弘聖

    日本外科学会定期学術集会抄録集   116回   PS - 044   2016.04

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    Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 胃癌微小環境における間質酵素Lysy Oxidase(LOX)familyのバイオマーカーとしての意義とその機能解析

    笠島 裕明, 八代 正和, 三木 友一朗, 北山 紀州, 増田 剛, 櫻井 克宣, 豊川 貴弘, 久保 尚士, 田中 浩明, 六車 一哉, 大平 雅一, 平川 弘聖

    日本外科学会定期学術集会抄録集   116回   OP - 015   2016.04

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  • Stage II胃癌における術前C-reactive protein/albumin ratio(CAR)の有用性 Reviewed

    豊川 貴弘, 六車 一哉, 大平 雅一, 田村 達郎, 渋谷 雅常, 櫻井 克宜, 山添 定明, 木村 健二郎, 永原 央, 天野 良亮, 久保 尚士, 田中 浩明, 八代 正和, 前田 清, 平川 弘聖

    (一社)日本胃癌学会, 日本胃癌学会総会記事   88回   350 - 350   2016.03

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  • ともに手術治療が第一選択となる同時性食道胃重複癌に対する手術方法の検討 Reviewed

    久保 尚士, 大平 雅一, 田村 達郎, 櫻井 克宣, 豊川 貴弘, 玉森 豊, 山下 好人, 田中 浩明, 六車 一哉, 八代 正和, 平川 弘聖

    (一社)日本胃癌学会, 日本胃癌学会総会記事   88回   277 - 277   2016.03

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  • 癌幹細胞におけるオートファジーの意義 Reviewed

    増田 剛, 八代 正和, 北山 紀州, 笠島 裕明, 三木 友一郎, 木下 春人, 福岡 達成, 森崎 珠美, 平川 弘聖

    (一社)日本胃癌学会, 日本胃癌学会総会記事   88回   431 - 431   2016.03

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  • 胃癌微小環境におけるリンパ管構築とマクロファージ Reviewed

    田内 幸枝, 田中 浩明, 崎村 千恵, 徳本 真央, 田村 達郎, 櫻井 克宣, 豊川 貴弘, 久保 尚士, 六車 一哉, 八代 正和, 大平 雅一, 平川 弘聖

    (一社)日本胃癌学会, 日本胃癌学会総会記事   88回   364 - 364   2016.03

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  • 胃癌に対する胃全摘が術後体組成に及ぼす影響 Reviewed

    櫻井 克宣, 田村 達郎, 渋谷 雅常, 山添 定明, 木村 健二郎, 永原 央, 豊川 貴弘, 天野 良亮, 久保 尚士, 田中 浩明, 六車 一哉, 八代 正和, 前田 清, 大平 雅一, 平川 弘聖

    (一社)日本胃癌学会, 日本胃癌学会総会記事   88回   346 - 346   2016.03

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  • 胃内分泌細胞癌10例の臨床病理学的検討 Reviewed

    後藤 航, 豊川 貴弘, 六車 一哉, 田村 達郎, 渋谷 雅常, 櫻井 克宣, 木村 健二郎, 永原 央, 天野 良亮, 久保 尚士, 田中 浩明, 八代 正和, 前田 清, 大平 雅一, 平川 弘聖

    (一社)日本胃癌学会, 日本胃癌学会総会記事   88回   430 - 430   2016.03

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  • 糖代謝酵素が低酸素状態の胃癌細胞増殖におよぼす影響の検討 Reviewed

    北山 紀州, 八代 正和, 森崎 珠実, 木下 春人, 福岡 達成, 笠島 裕明, 増田 剛, 平川 弘聖

    (一社)日本胃癌学会, 日本胃癌学会総会記事   88回   436 - 436   2016.03

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    Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 胃癌微小環境の骨髄由来細胞は癌の進展に関与する Reviewed

    笠島 裕明, 八代 正和, 中前 博久, 三木 友一朗, 北山 紀州, 増田 剛, 櫻井 克宣, 豊川 貴弘, 久保 尚士, 田中 浩明, 六車 一哉, 大平 雅一, 中根 孝彦, 日野 雅之, 平川 弘聖

    (一社)日本胃癌学会, 日本胃癌学会総会記事   88回   453 - 453   2016.03

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  • 腫瘍浸潤B細胞の胃癌における予後との関係 Reviewed

    崎村 千恵, 田中 浩明, 田内 幸枝, 田村 達郎, 櫻井 克宣, 豊川 貴弘, 久保 尚士, 山添 定明, 木村 健二郎, 天野 良亮, 六車 一哉, 八代 正和, 前田 清, 大平 雅一, 平川 弘聖

    (一社)日本胃癌学会, 日本胃癌学会総会記事   88回   365 - 365   2016.03

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  • Stage II胃癌における術前C-reactive protein/albumin ratio(CAR)の有用性

    豊川 貴弘, 六車 一哉, 大平 雅一, 田村 達郎, 渋谷 雅常, 櫻井 克宜, 山添 定明, 木村 健二郎, 永原 央, 天野 良亮, 久保 尚士, 田中 浩明, 八代 正和, 前田 清, 平川 弘聖

    日本胃癌学会総会記事   88回   350 - 350   2016.03

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  • ともに手術治療が第一選択となる同時性食道胃重複癌に対する手術方法の検討

    久保 尚士, 大平 雅一, 田村 達郎, 櫻井 克宣, 豊川 貴弘, 玉森 豊, 山下 好人, 田中 浩明, 六車 一哉, 八代 正和, 平川 弘聖

    日本胃癌学会総会記事   88回   277 - 277   2016.03

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  • 癌幹細胞におけるオートファジーの意義

    増田 剛, 八代 正和, 北山 紀州, 笠島 裕明, 三木 友一郎, 木下 春人, 福岡 達成, 森崎 珠美, 平川 弘聖

    日本胃癌学会総会記事   88回   431 - 431   2016.03

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  • 胃内分泌細胞癌10例の臨床病理学的検討

    後藤 航, 豊川 貴弘, 六車 一哉, 田村 達郎, 渋谷 雅常, 櫻井 克宣, 木村 健二郎, 永原 央, 天野 良亮, 久保 尚士, 田中 浩明, 八代 正和, 前田 清, 大平 雅一, 平川 弘聖

    日本胃癌学会総会記事   88回   430 - 430   2016.03

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  • 糖代謝酵素が低酸素状態の胃癌細胞増殖におよぼす影響の検討

    北山 紀州, 八代 正和, 森崎 珠実, 木下 春人, 福岡 達成, 笠島 裕明, 増田 剛, 平川 弘聖

    日本胃癌学会総会記事   88回   436 - 436   2016.03

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  • 胃癌に対する胃全摘が術後体組成に及ぼす影響

    櫻井 克宣, 田村 達郎, 渋谷 雅常, 山添 定明, 木村 健二郎, 永原 央, 豊川 貴弘, 天野 良亮, 久保 尚士, 田中 浩明, 六車 一哉, 八代 正和, 前田 清, 大平 雅一, 平川 弘聖

    日本胃癌学会総会記事   88回   346 - 346   2016.03

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  • 腫瘍浸潤B細胞の胃癌における予後との関係

    崎村 千恵, 田中 浩明, 田内 幸枝, 田村 達郎, 櫻井 克宣, 豊川 貴弘, 久保 尚士, 山添 定明, 木村 健二郎, 天野 良亮, 六車 一哉, 八代 正和, 前田 清, 大平 雅一, 平川 弘聖

    日本胃癌学会総会記事   88回   365 - 365   2016.03

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  • 胃癌微小環境の骨髄由来細胞は癌の進展に関与する

    笠島 裕明, 八代 正和, 中前 博久, 三木 友一朗, 北山 紀州, 増田 剛, 櫻井 克宣, 豊川 貴弘, 久保 尚士, 田中 浩明, 六車 一哉, 大平 雅一, 中根 孝彦, 日野 雅之, 平川 弘聖

    日本胃癌学会総会記事   88回   453 - 453   2016.03

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  • 胃癌微小環境におけるリンパ管構築とマクロファージ

    田内 幸枝, 田中 浩明, 崎村 千恵, 徳本 真央, 田村 達郎, 櫻井 克宣, 豊川 貴弘, 久保 尚士, 六車 一哉, 八代 正和, 大平 雅一, 平川 弘聖

    日本胃癌学会総会記事   88回   364 - 364   2016.03

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  • 75歳以上高齢胃癌患者の術前栄養評価の有用性 Reviewed

    櫻井 克宣, 田村 達郎, 永原 央, 豊川 貴弘, 天野 良亮, 久保 尚士, 田中 浩明, 六車 一哉, 八代 正和, 大平 雅一, 平川 弘聖

    (株)ジェフコーポレーション, 日本静脈経腸栄養学会雑誌   31 ( 1 )   277 - 277   2016.01( ISSN:2189-0161

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  • 75歳以上高齢胃癌患者の術前栄養評価の有用性 Reviewed

    櫻井 克宣, 田村 達郎, 永原 央, 豊川 貴弘, 天野 良亮, 久保 尚士, 田中 浩明, 六車 一哉, 八代 正和, 大平 雅一, 平川 弘聖

    (株)ジェフコーポレーション, 日本静脈経腸栄養学会雑誌   31 ( 1 )   277 - 277   2016.01( ISSN:2189-0161

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  • 胃癌患者における術後合併症とQOLの予測因子の検討 Reviewed

    平松 宗一郎, 櫻井 克宣, 田村 達郎, 山添 定明, 永原 央, 豊川 貴弘, 天野 良亮, 久保 尚士, 田中 浩明, 六車 一哉, 八代 正和, 前田 清, 大平 雅一, 平川 弘聖

    (株)ジェフコーポレーション, 日本静脈経腸栄養学会雑誌   31 ( 1 )   309 - 309   2016.01( ISSN:2189-0161

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  • 術前prognostic nutritional indexを用いた食道癌手術症例の術後短期および長期成績の検討 Reviewed

    後藤 航, 櫻井 克宣, 大平 雅一, 久保 尚士, 田村 達郎, 永原 央, 豊川 貴弘, 天野 良亮, 田中 浩明, 六車 一哉, 八代 正和, 平川 弘聖

    (株)ジェフコーポレーション, 日本静脈経腸栄養学会雑誌   31 ( 1 )   308 - 308   2016.01( ISSN:2189-0161

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  • 胃癌患者における術後合併症とQOLの予測因子の検討

    平松 宗一郎, 櫻井 克宣, 田村 達郎, 山添 定明, 永原 央, 豊川 貴弘, 天野 良亮, 久保 尚士, 田中 浩明, 六車 一哉, 八代 正和, 前田 清, 大平 雅一, 平川 弘聖

    日本静脈経腸栄養学会雑誌   31 ( 1 )   309 - 309   2016.01( ISSN:2189-0161

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  • 術前prognostic nutritional indexを用いた食道癌手術症例の術後短期および長期成績の検討

    後藤 航, 櫻井 克宣, 大平 雅一, 久保 尚士, 田村 達郎, 永原 央, 豊川 貴弘, 天野 良亮, 田中 浩明, 六車 一哉, 八代 正和, 平川 弘聖

    日本静脈経腸栄養学会雑誌   31 ( 1 )   308 - 308   2016.01( ISSN:2189-0161

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  • スキルス胃癌微小環境における細胞外小胞の機能 Reviewed

    内藤 寛, 八代 正和, 平川 弘聖, 安井 弥, 落谷 孝広

    (公社)日本生化学会, 日本生化学会大会・日本分子生物学会年会合同大会講演要旨集   88回・38回   [4T18L - 02(3P1079)]   2015.12

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  • 外科的治療を施行した食道裂孔ヘルニア症例の検討 Reviewed

    田村 達郎, 久保 尚士, 櫻井 克宣, 豊川 貴弘, 大平 雅一, 渋谷 雅常, 山添 定明, 永原 央, 木村 健二郎, 天野 良亮, 田中 浩明, 六車 一哉, 八代 正和, 前田 清, 平川 弘聖

    (一社)日本内視鏡外科学会, 日本内視鏡外科学会雑誌   20 ( 7 )   OS257 - 7   2015.12( ISSN:1344-6703

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  • 胃癌におけるオートファジーの臨床病理学的意義 Reviewed

    増田 剛, 八代 正和, 北山 紀州, 笠島 裕明, 木下 春人, 福岡 達成, 森崎 珠美, 久保 尚士, 田中 浩明, 六車 一哉, 大平 雅一, 平川 弘聖

    日本分子腫瘍マーカー研究会, 日本分子腫瘍マーカー研究会誌   31   70 - 70   2015.12

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  • 胃癌微小環境の骨髄由来細胞は癌の進展に関与する Reviewed

    笠島 裕明, 八代 正和, 中前 博久, 三木 友一朗, 北山 紀州, 増田 剛, 櫻井 克宜, 豊川 貴弘, 久保 尚士, 田中 浩明, 六車 一哉, 大平 雅一, 中根 孝彦, 日野 雅之, 平川 弘聖

    日本分子腫瘍マーカー研究会, 日本分子腫瘍マーカー研究会誌   31   71 - 72   2015.12

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  • 腹腔鏡下幽門側胃切除を施行した患者の術前栄養と合併症予測に関する検討 Reviewed

    櫻井 克宣, 田村 達郎, 豊川 貴弘, 久保 尚士, 田中 浩明, 六車 一哉, 渋谷 雅常, 山添 定明, 永原 央, 木村 健二郎, 天野 良亮, 八代 正和, 前田 清, 大平 雅一, 平川 弘聖

    (一社)日本内視鏡外科学会, 日本内視鏡外科学会雑誌   20 ( 7 )   OS105 - 4   2015.12( ISSN:1344-6703

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  • 胸腔鏡下食道亜全摘術及び二期再建術を行った食道癌、胃癌、大腸癌の同時性3重複癌の1例 Reviewed

    長嶋 大輔, 櫻井 克宣, 田村 達郎, 久保 尚士, 澁谷 雅常, 永原 央, 豊川 貴弘, 田中 浩明, 六車 一哉, 八代 正和, 前田 清, 大平 雅一, 平川 弘聖

    (一社)日本内視鏡外科学会, 日本内視鏡外科学会雑誌   20 ( 7 )   OS96 - 7   2015.12( ISSN:1344-6703

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  • スキルス胃癌微小環境における細胞外小胞の機能

    内藤 寛, 八代 正和, 平川 弘聖, 安井 弥, 落谷 孝広

    日本生化学会大会・日本分子生物学会年会合同大会講演要旨集   88回・38回   [4T18L - 02(3P1079)]   2015.12

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  • 外科的治療を施行した食道裂孔ヘルニア症例の検討

    田村 達郎, 久保 尚士, 櫻井 克宣, 豊川 貴弘, 大平 雅一, 渋谷 雅常, 山添 定明, 永原 央, 木村 健二郎, 天野 良亮, 田中 浩明, 六車 一哉, 八代 正和, 前田 清, 平川 弘聖

    日本内視鏡外科学会雑誌   20 ( 7 )   OS257 - 7   2015.12( ISSN:1344-6703

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  • 胸腔鏡下食道亜全摘術及び二期再建術を行った食道癌、胃癌、大腸癌の同時性3重複癌の1例

    長嶋 大輔, 櫻井 克宣, 田村 達郎, 久保 尚士, 澁谷 雅常, 永原 央, 豊川 貴弘, 田中 浩明, 六車 一哉, 八代 正和, 前田 清, 大平 雅一, 平川 弘聖

    日本内視鏡外科学会雑誌   20 ( 7 )   OS96 - 7   2015.12( ISSN:1344-6703

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  • 腹腔鏡下幽門側胃切除を施行した患者の術前栄養と合併症予測に関する検討

    櫻井 克宣, 田村 達郎, 豊川 貴弘, 久保 尚士, 田中 浩明, 六車 一哉, 渋谷 雅常, 山添 定明, 永原 央, 木村 健二郎, 天野 良亮, 八代 正和, 前田 清, 大平 雅一, 平川 弘聖

    日本内視鏡外科学会雑誌   20 ( 7 )   OS105 - 4   2015.12( ISSN:1344-6703

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  • がん関連糖鎖 がんマーカーとしての有用性と生物学的意義の統合的理解 癌組織微小環境におけるMUC1-レクチン相互作用による腫瘍悪性化 Reviewed

    中田 博, 森 勇伍, 秋田 薫, 八代 正和, 澤田 鉄二, 平川 弘聖

    日本癌学会, 日本癌学会総会記事   74回   S20 - 6   2015.10( ISSN:0546-0476

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  • スキルス胃癌微小環境における細胞外小胞の機能解析 Reviewed

    内藤 寛, 八代 正和, 平川 弘聖, 安井 弥, 落谷 孝広

    日本癌学会, 日本癌学会総会記事   74回   P - 1289   2015.10( ISSN:0546-0476

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  • ヒトがんにおけるmTORの体細胞変異が形質転換を起こす Reviewed

    山口 博之, 河津 正人, 曽田 学, 上野 敏秀, 小島 進也, 八代 正和, 吉野 一郎, 石川 雄一, 崔 永林, 河野 茂, 間野 博行

    日本癌学会, 日本癌学会総会記事   74回   P - 3021   2015.10( ISSN:0546-0476

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  • 胃癌におけるFGFR2-IIIb発現の臨床病理学的意義 Reviewed

    増田 剛, 八代 正和, 北山 紀州, 笠島 裕明, 木下 春人, 福岡 達成, 森崎 珠美, 久保 尚士, 田中 浩明, 六車 一哉, 大平 雅一, 平川 弘聖

    日本癌学会, 日本癌学会総会記事   74回   J - 1056   2015.10( ISSN:0546-0476

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  • 合併症を減らすステープリングデバイス、自動縫合器の使用方法 当院における尾側膵切除の膵切離法と膵液瘻の検討 Reviewed

    大平 豪, 天野 良亮, 木村 健二郎, 山添 定明, 渋谷 雅常, 櫻井 克宣, 永原 央, 豊川 貴弘, 久保 尚士, 田中 浩明, 六車 一哉, 八代 正和, 前田 清, 大平 雅一, 平川 弘聖

    日本臨床外科学会, 日本臨床外科学会雑誌   76 ( 増刊 )   473 - 473   2015.10( ISSN:1345-2843

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  • 初回手術として、胸腔鏡下食道切除、胃全摘、S状結腸切除、二期的に小腸による消化管再建術を施行した食道、胃、大腸同時性3重複癌の1切除例 Reviewed

    星 知秀, 田村 達郎, 櫻井 克宣, 久保 尚士, 澁谷 雅常, 永原 央, 田中 浩明, 六車 一哉, 八代 正和, 前田 清, 大平 雅一, 平川 弘聖

    日本臨床外科学会, 日本臨床外科学会雑誌   76 ( 増刊 )   1121 - 1121   2015.10( ISSN:1345-2843

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    DOI: 10.3919/jjsa.76.S1121

  • 低酸素環境における胃癌細胞の糖代謝関連酵素の細胞増殖に関する検討 Reviewed

    北川 紀州, 八代 正和, 森崎 珠実, 木下 春人, 福岡 達成, 笠島 裕明, 増田 剛, 長谷川 毅, 櫻井 克宜, 久保 尚士, 大平 雅一, 平川 弘聖

    日本癌学会, 日本癌学会総会記事   74回   J - 1372   2015.10( ISSN:0546-0476

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  • 主要動脈浸潤を伴うtechnical resectable局所進行膵癌に対する術前化学放射線療法 Reviewed

    大野 良亮, 木村 健二郎, 山添 定明, 西尾 康平, 大平 豪, 永原 央, 豊川 貴弘, 久保 尚士, 田中 浩明, 六車 一哉, 八代 正和, 前田 清, 仲田 文造, 大平 雅一, 平川 弘聖

    日本臨床外科学会, 日本臨床外科学会雑誌   76 ( 増刊 )   532 - 532   2015.10( ISSN:1345-2843

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  • 上皮間葉移行と幹細胞性は膵退形成癌への進展に関与する Reviewed

    三浦 光太郎, 木村 健二郎, 天野 良亮, 山添 定明, 大平 豪, 西尾 康平, 澁谷 雅常, 柏木 伸一郎, 櫻井 克宜, 八代 正和, 前田 清, 大平 雅一, 平川 弘聖

    日本癌学会, 日本癌学会総会記事   74回   P - 2202   2015.10( ISSN:0546-0476

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  • リシルオキシダーゼは低酸素環境において胃癌細胞のEMTに関与する Reviewed

    笠島 裕明, 八代 正和, 北山 紀州, 増田 剛, 木下 春人, 櫻井 克宣, 豊川 貴弘, 久保 尚士, 田中 浩明, 六車 一哉, 大平 雅一, 平川 弘聖

    日本癌学会, 日本癌学会総会記事   74回   E - 1062   2015.10( ISSN:0546-0476

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  • 胃癌患者の術前骨格筋量と術後合併症の関連についての検討 Reviewed

    田村 達郎, 櫻井 克宣, 六車 一哉, 渋谷 雅常, 山添 定明, 永原 央, 木村 健二郎, 豊川 貴弘, 天野 良亮, 久保 尚士, 田中 浩明, 八代 正和, 前田 清, 大平 雅一, 平川 弘聖

    日本臨床外科学会, 日本臨床外科学会雑誌   76 ( 増刊 )   693 - 693   2015.10( ISSN:1345-2843

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    DOI: 10.3919/jjsa.76.693

  • 高齢胃癌患者の治療成績と問題点 Reviewed

    櫻井 克宣, 田村 達郎, 豊川 貴弘, 久保 尚士, 田中 浩明, 六車 一哉, 渋谷 雅常, 山添 定明, 永原 央, 木村 健二郎, 天野 良亮, 八代 正和, 前田 清, 大平 雅一, 平川 弘聖

    日本臨床外科学会, 日本臨床外科学会雑誌   76 ( 増刊 )   526 - 526   2015.10( ISSN:1345-2843

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  • 転移・再発GISTに対する治療戦略 Reviewed

    豊川 貴弘, 六車 一哉, 田村 達郎, 渋谷 雅常, 櫻井 克宣, 山添 定明, 木村 健二郎, 永原 央, 天野 良亮, 久保 尚士, 田中 浩明, 八代 正和, 前田 清, 大平 雅一, 平川 弘聖

    日本臨床外科学会, 日本臨床外科学会雑誌   76 ( 増刊 )   635 - 635   2015.10( ISSN:1345-2843

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  • 高齢胃癌患者の治療成績と問題点

    櫻井 克宣, 田村 達郎, 豊川 貴弘, 久保 尚士, 田中 浩明, 六車 一哉, 渋谷 雅常, 山添 定明, 永原 央, 木村 健二郎, 天野 良亮, 八代 正和, 前田 清, 大平 雅一, 平川 弘聖

    日本臨床外科学会雑誌   76 ( 増刊 )   526 - 526   2015.10( ISSN:1345-2843

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  • がん関連糖鎖 がんマーカーとしての有用性と生物学的意義の統合的理解 癌組織微小環境におけるMUC1-レクチン相互作用による腫瘍悪性化

    中田 博, 森 勇伍, 秋田 薫, 八代 正和, 澤田 鉄二, 平川 弘聖

    日本癌学会総会記事   74回   S20 - 6   2015.10( ISSN:0546-0476

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  • スキルス胃癌微小環境における細胞外小胞の機能解析

    内藤 寛, 八代 正和, 平川 弘聖, 安井 弥, 落谷 孝広

    日本癌学会総会記事   74回   P - 1289   2015.10( ISSN:0546-0476

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  • 胃癌におけるFGFR2-IIIb発現の臨床病理学的意義

    増田 剛, 八代 正和, 北山 紀州, 笠島 裕明, 木下 春人, 福岡 達成, 森崎 珠美, 久保 尚士, 田中 浩明, 六車 一哉, 大平 雅一, 平川 弘聖

    日本癌学会総会記事   74回   J - 1056   2015.10( ISSN:0546-0476

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  • 合併症を減らすステープリングデバイス、自動縫合器の使用方法 当院における尾側膵切除の膵切離法と膵液瘻の検討

    大平 豪, 天野 良亮, 木村 健二郎, 山添 定明, 渋谷 雅常, 櫻井 克宣, 永原 央, 豊川 貴弘, 久保 尚士, 田中 浩明, 六車 一哉, 八代 正和, 前田 清, 大平 雅一, 平川 弘聖

    日本臨床外科学会雑誌   76 ( 増刊 )   473 - 473   2015.10( ISSN:1345-2843

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  • 初回手術として、胸腔鏡下食道切除、胃全摘、S状結腸切除、二期的に小腸による消化管再建術を施行した食道、胃、大腸同時性3重複癌の1切除例

    星 知秀, 田村 達郎, 櫻井 克宣, 久保 尚士, 澁谷 雅常, 永原 央, 田中 浩明, 六車 一哉, 八代 正和, 前田 清, 大平 雅一, 平川 弘聖

    日本臨床外科学会雑誌   76 ( 増刊 )   1121 - 1121   2015.10( ISSN:1345-2843

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    DOI: 10.3919/jjsa.76.S1121

  • 低酸素環境における胃癌細胞の糖代謝関連酵素の細胞増殖に関する検討

    北川 紀州, 八代 正和, 森崎 珠実, 木下 春人, 福岡 達成, 笠島 裕明, 増田 剛, 長谷川 毅, 櫻井 克宜, 久保 尚士, 大平 雅一, 平川 弘聖

    日本癌学会総会記事   74回   J - 1372   2015.10( ISSN:0546-0476

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  • 主要動脈浸潤を伴うtechnical resectable局所進行膵癌に対する術前化学放射線療法

    大野 良亮, 木村 健二郎, 山添 定明, 西尾 康平, 大平 豪, 永原 央, 豊川 貴弘, 久保 尚士, 田中 浩明, 六車 一哉, 八代 正和, 前田 清, 仲田 文造, 大平 雅一, 平川 弘聖

    日本臨床外科学会雑誌   76 ( 増刊 )   532 - 532   2015.10( ISSN:1345-2843

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  • 上皮間葉移行と幹細胞性は膵退形成癌への進展に関与する

    三浦 光太郎, 木村 健二郎, 天野 良亮, 山添 定明, 大平 豪, 西尾 康平, 澁谷 雅常, 柏木 伸一郎, 櫻井 克宜, 八代 正和, 前田 清, 大平 雅一, 平川 弘聖

    日本癌学会総会記事   74回   P - 2202   2015.10( ISSN:0546-0476

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  • リシルオキシダーゼは低酸素環境において胃癌細胞のEMTに関与する

    笠島 裕明, 八代 正和, 北山 紀州, 増田 剛, 木下 春人, 櫻井 克宣, 豊川 貴弘, 久保 尚士, 田中 浩明, 六車 一哉, 大平 雅一, 平川 弘聖

    日本癌学会総会記事   74回   E - 1062   2015.10( ISSN:0546-0476

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  • ヒトがんにおけるmTORの体細胞変異が形質転換を起こす

    山口 博之, 河津 正人, 曽田 学, 上野 敏秀, 小島 進也, 八代 正和, 吉野 一郎, 石川 雄一, 崔 永林, 河野 茂, 間野 博行

    日本癌学会総会記事   74回   P - 3021   2015.10( ISSN:0546-0476

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  • 胃癌患者の術前骨格筋量と術後合併症の関連についての検討

    田村 達郎, 櫻井 克宣, 六車 一哉, 渋谷 雅常, 山添 定明, 永原 央, 木村 健二郎, 豊川 貴弘, 天野 良亮, 久保 尚士, 田中 浩明, 八代 正和, 前田 清, 大平 雅一, 平川 弘聖

    日本臨床外科学会雑誌   76 ( 増刊 )   693 - 693   2015.10( ISSN:1345-2843

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    DOI: 10.3919/jjsa.76.693

  • 転移・再発GISTに対する治療戦略

    豊川 貴弘, 六車 一哉, 田村 達郎, 渋谷 雅常, 櫻井 克宣, 山添 定明, 木村 健二郎, 永原 央, 天野 良亮, 久保 尚士, 田中 浩明, 八代 正和, 前田 清, 大平 雅一, 平川 弘聖

    日本臨床外科学会雑誌   76 ( 増刊 )   635 - 635   2015.10( ISSN:1345-2843

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  • Oxaliplatin起因性末梢神経障害に対するPregabalinの予防効果の検討 Reviewed

    永原 央, 前田 清, 渋谷 雅常, 大谷 博, 菅野 兼史, 福岡 達成, 木村 健二郎, 豊川 貴弘, 天野 良亮, 久保 尚士, 田中 浩明, 六車 一哉, 八代 正和, 大平 雅一, 平川 弘聖

    (一社)日本癌治療学会, 日本癌治療学会誌   50 ( 3 )   1733 - 1733   2015.09( ISSN:0021-4671

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  • 低酸素環境における胃癌細胞の糖代謝関連酵素の細胞増殖に関する検討 Reviewed

    北山 紀州, 八代 正和, 森崎 珠実, 笠島 裕明, 増田 剛, 木下 春人, 福岡 達成, 櫻井 克宜, 豊川 貴弘, 久保 尚士, 田中 浩明, 六車 一哉, 大平 雅一, 平川 弘聖

    (一社)日本癌治療学会, 日本癌治療学会誌   50 ( 3 )   1588 - 1588   2015.09( ISSN:0021-4671

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  • 胃癌微小環境におけるリンパ管構築にマクロファージが関連する Reviewed

    田内 幸枝, 田中 浩明, 崎村 千恵, 徳本 真央, 櫻井 克宣, 豊川 貴弘, 久保 尚士, 山添 定明, 木村 健二郎, 天野 良亮, 六車 一哉, 八代 正和, 前田 清, 大平 雅一, 平川 弘聖

    (一社)日本癌治療学会, 日本癌治療学会誌   50 ( 3 )   1589 - 1589   2015.09( ISSN:0021-4671

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  • 胃癌リンパ節内の腫瘍関連リンパ管内皮細胞の同定と役割 Reviewed

    徳本 真央, 田中 浩明, 崎村 千恵, 田内 幸枝, 櫻井 克宣, 木村 健二郎, 永原 央, 豊川 貴弘, 天野 良亮, 久保 尚士, 六車 一哉, 八代 正和, 前田 清, 大平 雅一, 平川 弘聖

    (一社)日本癌治療学会, 日本癌治療学会誌   50 ( 3 )   1590 - 1590   2015.09( ISSN:0021-4671

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  • 胃癌におけるオートファジーの臨床病理学的意義 Reviewed

    増田 剛, 八代 正和, 北山 紀州, 笠島 裕明, 木下 春人, 福岡 達成, 森崎 珠美, 久保 尚士, 田中 浩明, 六車 一哉, 大平 雅一, 平川 弘聖

    日本分子腫瘍マーカー研究会, 日本分子腫瘍マーカー研究会プログラム・講演抄録   35回   98 - 98   2015.09

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  • 胃 胃がんのゲノム解析 胃癌の進展に及ぼす骨髄由来間質細胞の関与の検討 Reviewed

    笠島 裕明, 八代 正和, 中前 博久, 北山 紀州, 増田 剛, 木下 春人, 櫻井 克宣, 豊川 貴弘, 久保 尚士, 田中 浩明, 六車 一哉, 大平 雅一, 中根 孝彦, 日野 雅之, 平川 弘聖

    (一社)日本癌治療学会, 日本癌治療学会誌   50 ( 3 )   45 - 45   2015.09( ISSN:0021-4671

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  • 胃 胃がんのゲノム解析 胃癌におけるFGFR2-IIIb発現の臨床病理学的意義 Reviewed

    増田 剛, 八代 正和, 北山 紀州, 木下 春人, 福岡 達成, 森崎 珠美, 久保 尚志, 田中 浩明, 六車 一哉, 大平 雅一, 平川 弘聖

    (一社)日本癌治療学会, 日本癌治療学会誌   50 ( 3 )   47 - 47   2015.09( ISSN:0021-4671

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  • 潰瘍性大腸炎に対する腹腔鏡手術の位置づけとその定型化 Reviewed

    永原 央, 前田 清, 渋谷 雅常, 大谷 博, 池谷 哲郎, 井関 康仁, 木村 健二郎, 田中 浩明, 六車 一哉, 八代 正和, 大平 雅一, 鎌田 紀子, 山上 博一, 渡辺 憲治, 野田 英児, 井上 透, 西口 幸雄, 平川 弘聖

    (一社)日本大腸肛門病学会, 日本大腸肛門病学会雑誌   68 ( 9 )   718 - 718   2015.09( ISSN:0047-1801

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  • 切除可能cStage I-III食道扁平上皮癌における術前予後指標としてのCONUT scoreの意義 Reviewed

    豊川 貴弘, 久保 尚士, 大平 雅一, 田村 達郎, 櫻井 克宜, 渋谷 雅常, 山添 定明, 木村 健二郎, 永原 央, 天野 良亮, 田中 浩明, 六車 一哉, 八代 正和, 前田 清, 平川 弘聖

    (一社)日本癌治療学会, 日本癌治療学会誌   50 ( 3 )   648 - 648   2015.09( ISSN:0021-4671

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  • 胃癌微小環境の骨髄由来細胞は癌の進展に関与する Reviewed

    笠島 裕明, 八代 正和, 中前 博久, 三木 友一朗, 北山 紀州, 増田 剛, 櫻井 克宜, 豊川 貴弘, 久保 尚士, 田中 浩明, 六車 一哉, 大平 雅一, 中根 孝彦, 日野 雅之, 平川 弘聖

    日本分子腫瘍マーカー研究会, 日本分子腫瘍マーカー研究会プログラム・講演抄録   35回   100 - 101   2015.09

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  • 高齢者における大腸癌腹腔鏡手術の安全性と適応について Reviewed

    永原 央, 前田 清, 渋谷 雅常, 大谷 博, 池谷 哲郎, 井関 康仁, 木村 健二郎, 田中 浩明, 六車 一哉, 八代 正和, 大平 雅一, 野田 英児, 井上 透, 西口 幸雄, 平川 弘聖

    (一社)日本大腸肛門病学会, 日本大腸肛門病学会雑誌   68 ( 9 )   683 - 683   2015.09( ISSN:0047-1801

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  • 膵臓 膵がんトランスレーショナル・リサーチ 膵退形成癌の由来と治療標的に関する免疫組織学的検討 Reviewed

    三浦 光太郎, 木村 健二郎, 天野 良亮, 山添 定明, 西尾 康平, 大平 豪, 永原 央, 豊川 貴弘, 久保 尚士, 田中 浩明, 六車 一哉, 八代 正和, 前田 清, 大平 雅一, 平川 弘聖

    (一社)日本癌治療学会, 日本癌治療学会誌   50 ( 3 )   1001 - 1001   2015.09( ISSN:0021-4671

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  • Oxaliplatin起因性末梢神経障害に対するPregabalinの予防効果の検討

    永原 央, 前田 清, 渋谷 雅常, 大谷 博, 菅野 兼史, 福岡 達成, 木村 健二郎, 豊川 貴弘, 天野 良亮, 久保 尚士, 田中 浩明, 六車 一哉, 八代 正和, 大平 雅一, 平川 弘聖

    日本癌治療学会誌   50 ( 3 )   1733 - 1733   2015.09( ISSN:0021-4671

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  • 低酸素環境における胃癌細胞の糖代謝関連酵素の細胞増殖に関する検討

    北山 紀州, 八代 正和, 森崎 珠実, 笠島 裕明, 増田 剛, 木下 春人, 福岡 達成, 櫻井 克宜, 豊川 貴弘, 久保 尚士, 田中 浩明, 六車 一哉, 大平 雅一, 平川 弘聖

    日本癌治療学会誌   50 ( 3 )   1588 - 1588   2015.09( ISSN:0021-4671

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  • 胃癌におけるオートファジーの臨床病理学的意義

    増田 剛, 八代 正和, 北山 紀州, 笠島 裕明, 木下 春人, 福岡 達成, 森崎 珠美, 久保 尚士, 田中 浩明, 六車 一哉, 大平 雅一, 平川 弘聖

    日本分子腫瘍マーカー研究会プログラム・講演抄録   35回   98 - 98   2015.09

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  • 胃 胃がんのゲノム解析 胃癌の進展に及ぼす骨髄由来間質細胞の関与の検討

    笠島 裕明, 八代 正和, 中前 博久, 北山 紀州, 増田 剛, 木下 春人, 櫻井 克宣, 豊川 貴弘, 久保 尚士, 田中 浩明, 六車 一哉, 大平 雅一, 中根 孝彦, 日野 雅之, 平川 弘聖

    日本癌治療学会誌   50 ( 3 )   45 - 45   2015.09( ISSN:0021-4671

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  • 胃 胃がんのゲノム解析 胃癌におけるFGFR2-IIIb発現の臨床病理学的意義

    増田 剛, 八代 正和, 北山 紀州, 木下 春人, 福岡 達成, 森崎 珠美, 久保 尚志, 田中 浩明, 六車 一哉, 大平 雅一, 平川 弘聖

    日本癌治療学会誌   50 ( 3 )   47 - 47   2015.09( ISSN:0021-4671

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  • 潰瘍性大腸炎に対する腹腔鏡手術の位置づけとその定型化

    永原 央, 前田 清, 渋谷 雅常, 大谷 博, 池谷 哲郎, 井関 康仁, 木村 健二郎, 田中 浩明, 六車 一哉, 八代 正和, 大平 雅一, 鎌田 紀子, 山上 博一, 渡辺 憲治, 野田 英児, 井上 透, 西口 幸雄, 平川 弘聖

    日本大腸肛門病学会雑誌   68 ( 9 )   718 - 718   2015.09( ISSN:0047-1801

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  • 切除可能cStage I-III食道扁平上皮癌における術前予後指標としてのCONUT scoreの意義

    豊川 貴弘, 久保 尚士, 大平 雅一, 田村 達郎, 櫻井 克宜, 渋谷 雅常, 山添 定明, 木村 健二郎, 永原 央, 天野 良亮, 田中 浩明, 六車 一哉, 八代 正和, 前田 清, 平川 弘聖

    日本癌治療学会誌   50 ( 3 )   648 - 648   2015.09( ISSN:0021-4671

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  • 胃癌リンパ節内の腫瘍関連リンパ管内皮細胞の同定と役割

    徳本 真央, 田中 浩明, 崎村 千恵, 田内 幸枝, 櫻井 克宣, 木村 健二郎, 永原 央, 豊川 貴弘, 天野 良亮, 久保 尚士, 六車 一哉, 八代 正和, 前田 清, 大平 雅一, 平川 弘聖

    日本癌治療学会誌   50 ( 3 )   1590 - 1590   2015.09( ISSN:0021-4671

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  • 高齢者における大腸癌腹腔鏡手術の安全性と適応について

    永原 央, 前田 清, 渋谷 雅常, 大谷 博, 池谷 哲郎, 井関 康仁, 木村 健二郎, 田中 浩明, 六車 一哉, 八代 正和, 大平 雅一, 野田 英児, 井上 透, 西口 幸雄, 平川 弘聖

    日本大腸肛門病学会雑誌   68 ( 9 )   683 - 683   2015.09( ISSN:0047-1801

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  • 膵臓 膵がんトランスレーショナル・リサーチ 膵退形成癌の由来と治療標的に関する免疫組織学的検討

    三浦 光太郎, 木村 健二郎, 天野 良亮, 山添 定明, 西尾 康平, 大平 豪, 永原 央, 豊川 貴弘, 久保 尚士, 田中 浩明, 六車 一哉, 八代 正和, 前田 清, 大平 雅一, 平川 弘聖

    日本癌治療学会誌   50 ( 3 )   1001 - 1001   2015.09( ISSN:0021-4671

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  • 胃癌微小環境の骨髄由来細胞は癌の進展に関与する

    笠島 裕明, 八代 正和, 中前 博久, 三木 友一朗, 北山 紀州, 増田 剛, 櫻井 克宜, 豊川 貴弘, 久保 尚士, 田中 浩明, 六車 一哉, 大平 雅一, 中根 孝彦, 日野 雅之, 平川 弘聖

    日本分子腫瘍マーカー研究会プログラム・講演抄録   35回   100 - 101   2015.09

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  • 胃癌微小環境におけるリンパ管構築にマクロファージが関連する

    田内 幸枝, 田中 浩明, 崎村 千恵, 徳本 真央, 櫻井 克宣, 豊川 貴弘, 久保 尚士, 山添 定明, 木村 健二郎, 天野 良亮, 六車 一哉, 八代 正和, 前田 清, 大平 雅一, 平川 弘聖

    日本癌治療学会誌   50 ( 3 )   1589 - 1589   2015.09( ISSN:0021-4671

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  • Epithelial mesenchymal transition may contribute to anaplastic change of pancreatic ductal adenocarcinoma

    Kotaro Miura, Kenjiro Kimura, Ryosuke Amano, Sadaaki Yamazoe, Go Ohira, Kohei Nishio, Masatsune Shibutani, Katsunobu Sakurai, Hisashi Nagahara, Takahiro Toyokawa, Naoshi Kubo, Hiroaki Tanaka, Kazuya Muguruma, Hiroshi Otani, Masakazu Yashiro, Kiyoshi Maeda, Masaichi Ohira, Kosei Hirakawa

    CANCER RESEARCH   75   2015.08( ISSN:0008-5472 ( eISSN:1538-7445

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    DOI: 10.1158/1538-7445.AM2015-5276

  • Significance of an autophagy protein, microtubule-associated protein light chain 3 (LC3), in gastric cancer

    Go Masuda, Masakazu Yashiro, Hiroaki Kasashima, Haruhito Kinoshita, Tatsunari Fukuoka, Tamami Morisaki, Tsuyoshi Hasegawa, Katsunobu Sakurai, Takahiro Toyokawa, Naoshi Kubo, Hiroaki Tanaka, Kazuya Muguruma, Masaichi Ohira, Kosei Chung

    CANCER RESEARCH   75   2015.08( ISSN:0008-5472 ( eISSN:1538-7445

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    DOI: 10.1158/1538-7445.AM2015-992

  • SDF1 alpha/CXCR4 axis might be associated with growth-interaction between cancer-associated fibroblasts and gastric cancer cells in hypoxic tumor microenvironment

    Haruhito Kinoshita, Masakazu Yashiro, Hiroaki Kasashima, Go Masuda, Tamami Morisaki, Tatsunari Fukuoka, Katsunobu Sakurai, Takahiro Toyokawa, Kenjiro Kimura, Naoshi Kubo, Hiroaki Tanaka, Kazuya Muguruma, Masaichi Ohira, Kosei Hirakawa

    CANCER RESEARCH   75   2015.08( ISSN:0008-5472 ( eISSN:1538-7445

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    DOI: 10.1158/1538-7445.AM2015-436

  • Novel biomarkers for gastric cancer stem cells utilizing comparative proteomics analysis

    Masakazu Yashiro, Tamami Morisaki, Tsuyoshi Hasegawa, Anna Kakehashi, Haruhito Kinoshita, Tatsunari Fukuoka, Hiroaki Kasashima, Go Masuda, Katsunobu Sakurai, Naoshi Kubo, Hiroaki Tanaka, Kazuya Muguruma, Masaichi Ohira, Hideki Wanibuchi, Kosei Hirakawa

    CANCER RESEARCH   75   2015.08( ISSN:0008-5472 ( eISSN:1538-7445

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    DOI: 10.1158/1538-7445.AM2015-1405

  • Lysyl oxidase-like 2 (LOXL2) from cancer-associated fibroblasts stimulates the progression of gastric carcinoma

    Hiroaki Kasashima, Masakazu Yashiro, Kisyu Kitayama, Go Masuda, Haruhito Kinoshita, Katsunobu Sakurai, Takahiro Toyokawa, Naoshi Kubo, Hiroaki Tanaka, Kazuya Muguruma, Masaichi Ohira, Kosei Hirakawa

    CANCER RESEARCH   75   2015.08( ISSN:0008-5472 ( eISSN:1538-7445

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    DOI: 10.1158/1538-7445.AM2015-5063

  • 低酸素環境において癌関連線維芽細胞がスキルス胃癌細胞の増殖能に与える影響 Reviewed

    木下 春人, 八代 正和, 笠島 裕明, 増田 剛, 豊川 貴弘, 久保 尚志, 田中 浩明, 六車 一哉, 大平 雅一, 平川 弘聖

    (一社)日本消化器外科学会, 日本消化器外科学会総会   70回   P - 97   2015.07

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  • 胃癌低酸素環境において間質酵素Lysyl OxidaseはEMTを促進する Reviewed

    笠島 裕明, 八代 正和, 櫻井 克宣, 豊川 貴弘, 久保 尚士, 田中 浩明, 六車 一哉, 大平 雅一, 平川 弘聖

    (一社)日本消化器外科学会, 日本消化器外科学会総会   70回   O - 47   2015.07

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  • 術前化学放射線療法後の骨髄抑制は局所進行食道癌の長期予後を悪化させるか? Reviewed

    久保 尚士, 大平 雅一, 櫻井 克宣, 豊川 貴弘, 山下 好人, 田中 浩明, 六車 一哉, 八代 正和, 前田 清, 平川 弘聖

    (一社)日本消化器外科学会, 日本消化器外科学会総会   70回   O - 75   2015.07

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  • 高齢者消化器癌に対する治療戦略 栄養免疫指標からみた高齢胃癌患者の治療成績 Reviewed

    櫻井 克宣, 六車 一哉, 豊川 貴弘, 天野 良亮, 久保 尚士, 田中 浩明, 八代 正和, 前田 清, 大平 雅一, 平川 弘聖

    (一社)日本消化器外科学会, 日本消化器外科学会総会   70回   RS - 48   2015.07

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  • 低酸素環境において癌関連線維芽細胞がスキルス胃癌細胞の増殖能に与える影響

    木下 春人, 八代 正和, 笠島 裕明, 増田 剛, 豊川 貴弘, 久保 尚志, 田中 浩明, 六車 一哉, 大平 雅一, 平川 弘聖

    日本消化器外科学会総会   70回   P - 97   2015.07

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  • 胃癌低酸素環境において間質酵素Lysyl OxidaseはEMTを促進する

    笠島 裕明, 八代 正和, 櫻井 克宣, 豊川 貴弘, 久保 尚士, 田中 浩明, 六車 一哉, 大平 雅一, 平川 弘聖

    日本消化器外科学会総会   70回   O - 47   2015.07

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  • 高齢者消化器癌に対する治療戦略 栄養免疫指標からみた高齢胃癌患者の治療成績

    櫻井 克宣, 六車 一哉, 豊川 貴弘, 天野 良亮, 久保 尚士, 田中 浩明, 八代 正和, 前田 清, 大平 雅一, 平川 弘聖

    日本消化器外科学会総会   70回   RS - 48   2015.07

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  • 術前化学放射線療法後の骨髄抑制は局所進行食道癌の長期予後を悪化させるか?

    久保 尚士, 大平 雅一, 櫻井 克宣, 豊川 貴弘, 山下 好人, 田中 浩明, 六車 一哉, 八代 正和, 前田 清, 平川 弘聖

    日本消化器外科学会総会   70回   O - 75   2015.07

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  • The pretreatment Controlling Nutritional Status (CONUT) score as an independent prognostic factor in patients with clinical Stage I-III esophageal squamous cell carcinoma

    T. Toyokawa, N. Kubo, M. Shibutani, K. Sakurai, H. Nagahara, H. Tanaka, K. Muguruma, H. Ohtani, M. Yashiro, K. Maeda, M. Ohira, K. Hirakawa

    ANNALS OF ONCOLOGY   26   2015.06( ISSN:0923-7534 ( eISSN:1569-8041

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    DOI: 10.1093/annonc/mdv233.45

  • 上部消化管 胃癌におけるオートファジー関連蛋白p62の臨床病理学的検討 Reviewed

    増田 剛, 八代 正和, 笠島 裕明, 田内 幸枝, 徳本 真央, 木下 春人, 福岡 達成, 森崎 珠美, 櫻井 克宜, 豊川 貴弘, 久保 尚士, 田中 浩明, 六車 一哉, 大平 雅一, 平川 弘聖

    (一社)日本外科学会, 日本外科学会定期学術集会抄録集   115回   OP - 218   2015.04

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  • 肝胆膵 膵退形成癌に存在する腺管構造の意義 Reviewed

    三浦 光太郎, 木村 健二郎, 天野 良亮, 山添 定明, 西尾 康平, 大平 豪, 澁谷 雅常, 櫻井 克宣, 豊川 貴弘, 久保 尚士, 田中 浩明, 六車 一哉, 大谷 博, 八代 正和, 前田 清, 大平 雅一, 平川 弘聖

    (一社)日本外科学会, 日本外科学会定期学術集会抄録集   115回   OP - 057   2015.04

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  • 肝胆膵 肝動脈浸潤を伴う局所進行膵癌に対する化学放射線療法後の肝動脈合併膵切除術 Reviewed

    天野 良亮, 木村 健二郎, 山添 定明, 永原 央, 豊川 貴弘, 久保 尚士, 田中 浩明, 六車 一哉, 大谷 博, 八代 正和, 前田 清, 仲田 文造, 大平 雅一, 平川 弘聖

    (一社)日本外科学会, 日本外科学会定期学術集会抄録集   115回   OP - 063   2015.04

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  • 上部消化管 食道扁平上皮癌患者に対する食道切除術におけるBMIの影響 Reviewed

    久保 尚士, 櫻井 克宣, 大平 雅一, 豊川 貴弘, 山下 好人, 渋谷 雅常, 山添 定明, 木村 健二郎, 永原 央, 天野 良亮, 田中 浩明, 六車 一哉, 大谷 博, 八代 正和, 前田 清, 平川 弘聖

    (一社)日本外科学会, 日本外科学会定期学術集会抄録集   115回   OP - 212   2015.04

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  • 上部消化管 胃癌所属リンパ節への炎症細胞の浸潤とその相関 Reviewed

    徳本 真央, 田中 浩明, 崎村 千恵, 田内 幸枝, 渋谷 雅常, 櫻井 克宣, 山添 定明, 永原 央, 木村 健二郎, 豊川 貴弘, 天野 良亮, 久保 尚士, 六車 一哉, 大谷 博, 八代 正和, 前田 清, 大平 雅一, 平川 弘聖

    (一社)日本外科学会, 日本外科学会定期学術集会抄録集   115回   OP - 009   2015.04

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  • 上部消化管 胃癌におけるオートファジー関連蛋白p62の臨床病理学的検討

    増田 剛, 八代 正和, 笠島 裕明, 田内 幸枝, 徳本 真央, 木下 春人, 福岡 達成, 森崎 珠美, 櫻井 克宜, 豊川 貴弘, 久保 尚士, 田中 浩明, 六車 一哉, 大平 雅一, 平川 弘聖

    日本外科学会定期学術集会抄録集   115回   OP - 218   2015.04

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  • 肝胆膵 膵退形成癌に存在する腺管構造の意義

    三浦 光太郎, 木村 健二郎, 天野 良亮, 山添 定明, 西尾 康平, 大平 豪, 澁谷 雅常, 櫻井 克宣, 豊川 貴弘, 久保 尚士, 田中 浩明, 六車 一哉, 大谷 博, 八代 正和, 前田 清, 大平 雅一, 平川 弘聖

    日本外科学会定期学術集会抄録集   115回   OP - 057   2015.04

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  • 肝胆膵 肝動脈浸潤を伴う局所進行膵癌に対する化学放射線療法後の肝動脈合併膵切除術

    天野 良亮, 木村 健二郎, 山添 定明, 永原 央, 豊川 貴弘, 久保 尚士, 田中 浩明, 六車 一哉, 大谷 博, 八代 正和, 前田 清, 仲田 文造, 大平 雅一, 平川 弘聖

    日本外科学会定期学術集会抄録集   115回   OP - 063   2015.04

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  • 上部消化管 食道扁平上皮癌患者に対する食道切除術におけるBMIの影響

    久保 尚士, 櫻井 克宣, 大平 雅一, 豊川 貴弘, 山下 好人, 渋谷 雅常, 山添 定明, 木村 健二郎, 永原 央, 天野 良亮, 田中 浩明, 六車 一哉, 大谷 博, 八代 正和, 前田 清, 平川 弘聖

    日本外科学会定期学術集会抄録集   115回   OP - 212   2015.04

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  • 上部消化管 胃癌所属リンパ節への炎症細胞の浸潤とその相関

    徳本 真央, 田中 浩明, 崎村 千恵, 田内 幸枝, 渋谷 雅常, 櫻井 克宣, 山添 定明, 永原 央, 木村 健二郎, 豊川 貴弘, 天野 良亮, 久保 尚士, 六車 一哉, 大谷 博, 八代 正和, 前田 清, 大平 雅一, 平川 弘聖

    日本外科学会定期学術集会抄録集   115回   OP - 009   2015.04

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  • Effect of cancer associated fibroblast on gastric cancer cells under hypoxia

    Haruhito Kinoshita, Masakazu Yashiro, Go Masuda, Hiroaki Kasashima, Tamami Morisaki, Tatsunari Fukuoka, Masatune Shibutani, Sadaaki Yamazoe, Katsunobu Sakurai, Hisashi Nagahara, Kenjiro Kimura, Takahiro Toyokawa, Ryosuke Amano, Naoshi Kubo, Hiroaki Tanaka, Kazuya Muguruma, Hiroshi Otani, Kiyoshi Maeda, Masaichi Ohira, Kosei Hirakawa

    CANCER RESEARCH   74 ( 19 )   2014.10( ISSN:0008-5472 ( eISSN:1538-7445

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    DOI: 10.1158/1538-7445.AM2014-3612

  • Role of lysyl oxidase and lysyl oxidase-like 2 in gastric carcinoma

    Hiroaki Kasashima, Masakazu Yashiro, Yukie Go, Go Masuda, Haruhito Kinoshita, Mao Tokumoto, Tamami Morisaki, Tatsunari Fukuoka, Takahiro Toyokawa, Naoshi Kubo, Hiroaki Tanaka, Kazuya Muguruma, Masaichi Ohira, Kosei Hirakawa

    CANCER RESEARCH   74 ( 19 )   2014.10( ISSN:0008-5472 ( eISSN:1538-7445

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    DOI: 10.1158/1538-7445.AM2014-1980

  • Extent of intranodal macrophage correlates with lymph node metastasis of gastric cancer

    Yukie Go, Hiroaki Tanaka, Mao Tokumoto, Yoshihiro Okita, Masatsune Shibutani, Sadaaki Yamazoe, Katsunobu Sakurai, Hisashi Nagahara, Kenjiro Kimura, Takahiro Toyokawa, Ryosuke Amano, Naoshi Kubo, Kazuya Muguruma, Hiroshi Otani, Masakazu Yashiro, Kiyoshi Maeda, Masaichi Ohira, Kosei Hirakawa

    CANCER RESEARCH   74 ( 19 )   2014.10( ISSN:0008-5472 ( eISSN:1538-7445

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    DOI: 10.1158/1538-7445.AM2014-1081

  • Establishment and characterization of two cell lines of anaplastic pancreatic cancer

    Kotaro Miura, Kenjiro Kimura, Ryosuke Amano, Sadaaki Yamazoe, Keiichiro Hirata, Masatsune Shibutani, Katsunobu Sakurai, Hisashi Nagahara, Takahiro Toyokawa, Naoshi Kubo, Hiroaki Tanaka, Kazuya Muguruma, Hiroshi Otani, Masakazu Yashiro, Kiyoshi Maeda, Masaichi Ohira, Kosei Hirakawa

    CANCER RESEARCH   74 ( 19 )   2014.10( ISSN:0008-5472 ( eISSN:1538-7445

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    DOI: 10.1158/1538-7445.AM2014-3924

  • Significance of preoperative nutritional assessment for gastric cancer patients with gastrectomy

    Katsunobu Sakurai, Kazuya Muguruma, Takahiro Toyokawa, Naoshi Kubo, Hiroaki Tanaka, Masakazu Yashiro, Masaichi Ohira, Kosei Hirakawa

    JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS   219 ( 4 )   E173 - E173   2014.10( ISSN:1072-7515 ( eISSN:1879-1190

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  • The stemness of gastric cancer stem cells is sustained by TGF beta produced from cancer-associated fibroblasts

    Masakazu Yashiro, Tsuyoshi Hasegawa, Tatsunari Fukuoka, Haruhito Kinoshita, Tamami Morisaki, Hiroaki Kasashima, Go Masuda, Naoshi Kubo, Kosei Hirakawa

    CANCER RESEARCH   74 ( 19 )   2014.10( ISSN:0008-5472 ( eISSN:1538-7445

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    DOI: 10.1158/1538-7445.AM2014-3863

  • The effect of PGE2 receptor inhibitor on the microenviroment of scirrhous gastric cancer

    Tatsunari Fukuoka, Masakazu Yashiro, Hiroshi Takeda, Takayuki Maruyama, Hiroaki Kasashima, Go Masuda, Haruhito Kinoshita, Tamami Morisaki, Katsunobu Sakurai, Masatsune Shibutani, Sadaaki Yamazoe, Kenjiro Kimura, Hisashi Nagahara, Takahiro Toyokawa, Ryosuke Amano, Naoshi Kubo, Hiroaki Tanaka, Kazuya Muguruma, Hiroshi Otani, Kiyoshi Maeda, Masaichi Ohira, Kosei Hirakawa

    CANCER RESEARCH   74 ( 19 )   2014.10( ISSN:0008-5472 ( eISSN:1538-7445

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    DOI: 10.1158/1538-7445.AM2014-3606

  • Stromal fibroblasts mediate extracellular matrix remodeling and invasion of scirrhous gastric carcinoma cells

    Hideki Yamaguchi, Kazuyoshi Yanagihara, Masakazu Yashiro, Ryuichi Sakai

    CANCER RESEARCH   74 ( 19 )   2014.10( ISSN:0008-5472 ( eISSN:1538-7445

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    DOI: 10.1158/1538-7445.AM2014-3601

  • プロテオーム解析による胃癌幹細胞関連マーカーの同定 Reviewed

    森崎 珠実, 八代 正和, 梯 アンナ, 笠島 裕明, 増田 剛, 木下 春人, 櫻井 克宣, 豊川 貴弘, 久保 尚士, 田中 浩明, 六車 一哉, 大平 雅一, 鰐渕 英機, 平川 弘聖

    日本分子腫瘍マーカー研究会, 日本分子腫瘍マーカー研究会誌   29   40 - 41   2014.04

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  • 【最新胃癌学-基礎と臨床の最新研究動向-】スキルス胃癌 浸潤・腹膜播種性転移 臨床と基礎 Reviewed

    八代 正和

    (株)日本臨床社 日本臨床   72 ( 増刊1 最新胃癌学 )   619 - 623   2014.01( ISSN:0047-1852

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  • 固形癌DICにおける遺伝子組み換えヒトトロンボモジュリン製剤の使用経験

    浅野 有香, 柏木 伸一郎, 野田 諭, 豊川 貴弘, 天野 良亮, 久保 尚士, 田中 浩明, 六車 一哉, 大谷 博, 高島 勉, 八代 正和, 小野田 尚佳, 前田 清, 大平 雅一, 平川 弘聖

    日本臨床外科学会雑誌   74 ( 増刊 )   692 - 692   2013.10( ISSN:1345-2843

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  • FEC+wPTX耐性TNBC細胞株の樹立とNAC効果予測因子としての癌幹細胞マーカーの意義

    青松 直撥, 八代 正和, 柏木 伸一郎, 野田 諭, 川尻 成美, 石原 沙江, 浅野 有香, 渡邊 真央, 森崎 珠実, 高島 勉, 小野田 尚佳, 石川 哲郎, 若狭 研一, 平川 弘聖

    日本癌治療学会誌   48 ( 3 )   1110 - 1110   2013.09( ISSN:0021-4671

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  • 消化器外科セミナー スキルス胃癌の病態と治療 Reviewed

    八代 正和, 豊川 貴弘, 櫻井 克宣, 久保 尚士, 田中 浩明, 六車 一哉, 大平 雅一, 平川 弘聖

    (株)へるす出版 消化器外科   36 ( 8 )   1235 - 1241   2013.07( ISSN:0387-2645

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  • 消化器外科セミナー スキルス胃癌の病態と治療 Reviewed

    八代 正和, 豊川 貴弘, 櫻井 克宣, 久保 尚士, 田中 浩明, 六車 一哉, 大平 雅一, 平川 弘聖

    消化器外科   36 ( 8 )   1235 - 1241   2013.07( ISSN:0387-2645

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  • トリプルネガティブ乳癌におけるVEGF/VEGFR-2シグナル阻害剤の意義

    青松 直撥, 八代 正和, 柏木 伸一郎, 野田 諭, 高島 勉, 川尻 成美, 池田 克実, 小川 佳成, 小野田 尚佳, 平川 弘聖

    日本乳癌学会総会プログラム抄録集   21回   349 - 349   2013.06

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  • Antitumor effect of prostaglandin D2 by peroxisome proliferator-activated receptor gamma (PPAR gamma)-dependent pathway in gastric carcinoma

    Tatsunari Fukuoka, Masakazu Yashiro, Hiroshi Takeda, Takayuki Maruyama, Haruhito Kinoshita, Tamammi Morisaki, Tsuyoshi Hasegawa, Toshiki Hirakawa, Naoki Aomatsu, Katsunobu Sakurai, Kenjiro Kimura, Hisashi Nagahara, Takahiro Toyokawa, Ryosuke Amano, Eiji Noda, Naoshi Kubo, Hiroaki Tanaka, Kazuya Muguruma, Hiroshi Otani, Kiyoshi Maeda, Masaichi Ohira, Kosei Hirakawa

    CANCER RESEARCH   73 ( 8 )   2013.04( ISSN:0008-5472 ( eISSN:1538-7445

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    DOI: 10.1158/1538-7445.AM2013-3995

  • Significance of CXCR4/SDF-1 axis expression in gastric cancer under hypoxic enviroment

    Haruhito Kinoshita, Masakazu Yashiro, Tamami Morisaki, Tatsunari Fukuoka, Tsuyoshi Hasegawa, Toshiki Hirakawa, Naoki Aomatsu, Katsunobu Sakurai, Kenjiro Kimura, Hisashi Nagahara, Takahiro Toyokawa, Ryosuke Amano, Eiji Noda, Naoshi Kubo, Hiroaki Tanaka, Kazuya Muguruma, Hiroshi Otani, Kiyoshi Maeda, Masaichi Ohira, Kosei Hirakawa

    CANCER RESEARCH   73 ( 8 )   2013.04( ISSN:0008-5472 ( eISSN:1538-7445

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  • 乳癌術前化学療法効果予測因子としての癌幹細胞マーカーの意義

    青松 直撥, 八代 正和, 木下 春人, 森崎 珠実, 福岡 達成, 平川 俊基, 長谷川 毅, 柏木 伸一郎, 高島 勉, 川尻 成美, 小野田 尚佳, 石川 哲郎, 平川 弘聖

    日本外科学会雑誌   114 ( 臨増2 )   522 - 522   2013.03( ISSN:0301-4894

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  • Inhibition of RAGE signaling through the intracellular delivery of inhibitor peptides by PEI cationization.

    Ohashi M, Oyama T, Putranto EW, Waku T, Nobusada H, Kataoka K, Matsuno K, Yashiro M, Morikawa K, Huh NH, Miyachi H

    Int J Mol Med   32 ( 4 )   938 - 944   2013

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    DOI: 10.3892/ijmm.2013.1467

  • 水溶性向上を指向したα‐ベンジルフェニルプロピオン酸型PPARγ選択的パーシャルアゴニストの創製

    大橋雅生, 大山拓次, 和久剛, 片岡健, 八代正和, 許南浩, 宮地弘幸

    メディシナルケミストリーシンポジウム講演要旨集   30th   73   2012.11( ISSN:0919-214X

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    J-GLOBAL

  • 【胃癌の予防と治療-予防策と早期診断・治療-】スキルス胃癌の増殖進展機序 Reviewed

    八代 正和, 大平 雅一, 六車 一哉, 神藤 理, 平川 弘聖

    日本臨床   70 ( 10 )   1812 - 1816   2012.10( ISSN:0047-1852

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  • 予後規定因子からみた大腸癌肝転移の治療戦略

    天野 良亮, 木村 健二郎, 山田 靖哉, 永原 央, 野田 英児, 久保 尚士, 田中 浩明, 六車 一哉, 八代 正和, 小野田 尚佳, 前田 清, 仲田 文造, 大平 雅一, 石川 哲郎, 平川 弘聖

    日本癌治療学会誌   47 ( 3 )   1200 - 1200   2012.10( ISSN:0021-4671

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  • 【EMTのUP DATE】EMTと胃癌 Reviewed

    八代 正和, 松岡 順子, 加藤 幸裕, 冬廣 雄彦, 神藤 理, 松岡 翼, 平川 弘聖

    Surgery Frontier   19 ( 3 )   297 - 304   2012.09( ISSN:1340-5594

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    上皮間葉移行(epithelial-mesenchymal transition;EMT)は発生期に必須の現象であるとともに腫瘍細胞の浸潤転移にも関係している。胃癌組織の微小環境には、低酸素状態やH.pylori感染などの炎症状態、あるいは間質細胞の存在があり、これらがEMTの誘因となっている。EMTに関連するシグナル伝達系は多岐にわたるが、主にはTGFβ/TGFβR/Smad系やHGF/cMet系などのシグナルが知られている。EMTに関連する転写因子にはSnail、Slug、Zeb1、Zeb2、TwistなどがありEカドヘリンを抑制する。これらの因子により上皮性胃癌細胞はEカドヘリン発現が低下してNカドヘリンを発現し(カドヘリンスイッチ)、またビメンチン発現など間葉性の性格を示し運動能を亢進する。臨床的にも、これらEMTに関連する因子の多くが胃癌の転移や予後に関連する。胃癌治療に有用なEMT阻害剤の開発が期待される。(著者抄録)

  • SIGNIFICANCE OF C-MET AS A THERAPEUTIC TARGET IN TRIPLE-NEGATIVE BREAST CANCER

    S. Kashiwagi, M. Yashiro, N. Aomatsu, H. Kawajiri, T. Takashima, N. Onoda, T. Ishikawa, K. Hirakawa

    ANNALS OF ONCOLOGY   23   84 - 84   2012.09( ISSN:0923-7534

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  • VEGF/VEGFR-2シグナル阻害剤のトリプルネガティブ乳癌に対する意義(Significance of VEGF/VEGFR-2 signaling inhibitor in triple-negative breast cancer)

    青松 直撥, 八代 正和, 柏木 伸一郎, 森崎 珠実, 福岡 達成, 平川 俊基, 長谷川 毅, 高島 勉, 川尻 成美, 小野田 尚佳, 石川 哲郎, 平川 弘聖

    日本癌学会総会記事   71回   501 - 501   2012.08( ISSN:0546-0476

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  • 【スキルス胃癌-診断・治療の現状と今後】スキルス胃癌の分子生物学 分子標的治療を目指して スキルス胃癌の浸潤・転移 腹膜播種形成の分子機構 Reviewed

    八代 正和, 冬廣 雄彦, 松岡 順子, 長谷川 毅, 野田 諭, 平川 弘聖

    臨床消化器内科   27 ( 9 )   1185 - 1189   2012.07( ISSN:0911-601X

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    スキルス胃癌細胞の腹膜播種転移に関連する因子を分子生物学的な観点から述べる.癌細胞の原発巣からの離脱過程には,MMP-1産生による間質分解亢進,細胞間接着に関与するE-cadherinやdesmoglein-2の発現低下が重要である.腹膜との接着過程には,癌細胞CD44Hおよびα2β1-integrin,α3β1-integrinと腹膜マトリックスとの接着が関与している.腹膜の線維芽細胞の産生するTGFβ,HGF,MMPにより癌細胞の浸潤が促進され,また中皮細胞の形態が変化する.低酸素環境はこれらを亢進させる.これらの機序に基づいた細胞接着阻害薬や,TGFβレセプター阻害薬,線維芽細胞抑制薬などの分子標的治療薬が期待される.(著者抄録)

  • Triple Negative乳癌における術前化学療法効果予測因子としてのCarbonic anhydrase 9の有用性

    青松 直撥, 八代 正和, 柏木 伸一郎, 森崎 珠実, 中村 雅憲, 高島 勉, 川尻 成美, 小野田 尚佳, 石川 哲郎, 平川 弘聖

    日本乳癌学会総会プログラム抄録集   20回   326 - 326   2012.05

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  • トリプルネガティブ乳癌におけるK-sam発現の臨床的意義とFGF-R2阻害剤の抗腫瘍効果

    柏木 伸一郎, 八代 正和, 高島 勉, 浅野 有香, 青松 直撥, 川尻 成美, 池田 克実, 小川 佳成, 小野田 尚佳, 石川 哲郎, 平川 弘聖

    日本乳癌学会総会プログラム抄録集   20回   326 - 326   2012.05

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  • An EGFR inhibitor enhances the efficacy of SN38, an active metabolite of irinotecan, in SN38-refractory gastric carcinoma cells

    Masakazu Yashiro, Hong Qiu, Tsuyoshi Hasegawa, Xiaotian Zhang, Tamami Morisaki, Tatsuynari Fukuoka, Naoki Aomatsu, Toshiki Hirakawa, Katsunobu Sakurai, Naoshi Kubo, Hiroaki Tanaka, Nobuya Yamada, Kiyoshi Maeda, Tetsuji Sawada, Masaichi Ohira, Kosei Hirakawa

    CANCER RESEARCH   72   2012.04( ISSN:0008-5472 ( eISSN:1538-7445

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    DOI: 10.1158/1538-7445.AM2012-780

  • Relationship between loss of heterozygosity of HLA-A gene and HLA class I expression in gastric cancer

    Mami Yoshii, Hiroaki Tanaka, Katsunobu Sakurai, Hisashi Nagahara, Kenjiro Kimura, Ryosuke Amano, Eiji Noda, Naoshi Kubo, Kazuya Muguruma, Nobuya Yamada, Masakazu Yashiro, Kiyoshi Maeda, Tetsuji Sawada, Masaichi Ohira, Tetsuro Ishikawa, Kosei Hirakawa

    CANCER RESEARCH   72   2012.04( ISSN:0008-5472 ( eISSN:1538-7445

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    DOI: 10.1158/1538-7445.AM2012-514

  • Predictive value of metastatic lymph node ratio in diagnosis of recurrence after surgical resection of gastric cancer

    Hiroaki Tanaka, Kazuya Muguruma, Mami Yoshii, Tomohiro Lee, Kenjiro Kimura, Hisashi Nagahara, Eiji Noda, Ryosuke Amano, Naoshi Kubo, Masakazu Yashiro, Nobuya Yamada, Kiyoshi Maeda, Tetsuji Sawada, Masaichi Ohira, Kosei Hirakawa

    CANCER RESEARCH   72   2012.04( ISSN:0008-5472 ( eISSN:1538-7445

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    DOI: 10.1158/1538-7445.AM2012-3396

  • Comparison proteome analysis of scirrhous gastric carcinoma stem cell-like SP and hypoxia-resistant cell lines

    Tamami Morisaki, Masakazu Yashiro, Anna Kakehashi, Yoshihiro Okita, Tatsunari Fukuoka, Naoki Aomatsu, Mami Yoshii, Tsuyoshi Hasegawa, Junko Matsuoka, Hisashi Nagahara, Kenjiro Kimura, Eiji Noda, Ryosuke Amano, Naoshi Kubo, Hiroaki Tanaka, Kazuya Muguruma, Nobuya Yamada, Kiyoshi Maeda, Bunzo Nakata, Masaichi Ohira, Hideki Wanibuchi, Kosei Hirakawa

    CANCER RESEARCH   72   2012.04( ISSN:0008-5472 ( eISSN:1538-7445

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    DOI: 10.1158/1538-7445.AM2012-3380

  • Clinical significance of insulin-like growth factor 1 receptor (IGF1R) expression in pancreatic cancer

    Toshiki Hirakawa, Masakazu Yashiro, Tamami Morisaki, Naoki Aomatsu, Tatsunari Fukuoka, Mami Yoshii, Tsuyoshi Hasegawa, Junko Matsuoka, Hisashi Nagahara, Kenjiro Kimura, Eiji Noda, Ryosuke Amano, Naoshi Kubo, Hiroaki Tanaka, Kazuya Muguruma, Nobuya Yamada, Kiyoshi Maeda, Bunzo Nakata, Masaichi Ohira, Kosei Hirakawa

    CANCER RESEARCH   72   2012.04( ISSN:0008-5472 ( eISSN:1538-7445

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    DOI: 10.1158/1538-7445.AM2012-708

  • Cancer-associated fibroblasts mediate extracellular matrix remodeling and three-dimensional invasion of scirrhous gastric carcinoma cells

    Hideki Yamaguchi, Kazuyoshi Yanagihara, Masakazu Yashiro, Ryuichi Sakai

    CANCER RESEARCH   72   2012.04( ISSN:0008-5472 ( eISSN:1538-7445

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    DOI: 10.1158/1538-7445.AM2012-47

  • Antitumor effect of prostaglandin E2 receptor inhibitors in gastric carcinoma

    Tatsunari Fukuoka, Masakazu Yashiro, Hiroshi Takeda, Takayuki Maruyama, Tamami Morisaki, Tsuyoshi Hasegawa, Toshiki Hirakawa, Naoki Aomatshu, Junko Matsuoka, Katsunobu Sakurai, Kenjiro Kimura, Hisashi Nagahara, Ryosuke Amano, Eiji Noda, Naoshi Kubo, Hiroaki Tanaka, Kazuya Muguruma, Nobuya Yamada, Kiyoshi Maeda, Masaichi Ohira, Tetsuro Ishikawa, Kosei Hirakawa

    CANCER RESEARCH   72   2012.04( ISSN:0008-5472 ( eISSN:1538-7445

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    DOI: 10.1158/1538-7445.AM2012-1211

  • TGF-beta from niche fibroblasts increases the stemness cancer stem cell-like side population cells in gastric cancer

    Tsuyoshi Hasegawa, Masakazu Yashiro, Tamami Morisaki, Naoki Aomatsu, Toshiki Hirakawa, Tatsunari Fukuoka, Junko Matsuoka, Katsunobu Sakurai, Kenjiro Kimura, Hisashi Nagahara, Ryosuke Amano, Eiji Noda, Naoshi Kubo, Hiroaki Tanaka, Kazuya Muguruma, Nobuya Yamada, Kiyoshi Maeda, Masaichi Ohira, Tetsuro Ishikawa, Kosei Hirakawa

    CANCER RESEARCH   72   2012.04( ISSN:0008-5472 ( eISSN:1538-7445

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    DOI: 10.1158/1538-7445.AM2012-3337

  • The expression of human equilibrative nucleoside transporter 1 (hENT1) is associated with overall survival in advanced biliary tract carcinoma (BTC) treated with gemcitabine

    Akihiro Murata, Ryousuke Amano, Kenjiro Kimura, Nobuya Yamada, Bunzo Nakata, Hisashi Nagahara, Eiji Noda, Naoshi Kubo, Hiroaki Tanaka, Kazuya Muguruma, Masakazu Yashiro, Kiyoshi Maeda, Masaichi Ohira, Tetsurou Ishikawa, Kosei Hirakawa

    CANCER RESEARCH   72   2012.04( ISSN:0008-5472 ( eISSN:1538-7445

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    DOI: 10.1158/1538-7445.AM2012-711

  • The epithelial-mesenchymal transition of gastric cancer cells was stimulated by TGF beta R signaling in hypoxia

    Junko Matsuoka, Masakazu Yashiro, Naoki Aomatsu, Toshiki Hirakawa, Tsuyoshi Hasegawa, Tatsunari Fukuoka, Tamami Morisaki, Naoshi Kubo, Hiroaki Tanaka, Kazuya Muguruma, Nobuya Yamada, Masaichi Ohira, Tetsuro Ishikawa, Kosei Hirakawa

    CANCER RESEARCH   72   2012.04( ISSN:0008-5472 ( eISSN:1538-7445

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    DOI: 10.1158/1538-7445.AM2012-2411

  • 乳癌術前化学療法における低酸素マーカーCarbonic anhydrase 9の有用性

    青松 直撥, 八代 正和, 森崎 珠実, 福岡 達成, 平川 俊基, 長谷川 毅, 松岡 順子, 柏木 伸一郎, 高島 勉, 川尻 成美, 小野田 尚佳, 石川 哲郎, 平川 弘聖

    日本外科学会雑誌   113 ( 臨増2 )   315 - 315   2012.03( ISSN:0301-4894

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  • 大腸癌同時性腹膜播種症例の臨床病理学的検討

    野田 英児, 前田 清, 永原 央, 井上 透, 木村 健二郎, 天野 良亮, 渋谷 雅常, 久保 尚士, 田中 浩明, 六車 一哉, 八代 正和, 山田 靖哉, 高島 勉, 小野田 尚佳, 仲田 文造, 川尻 成美, 西口 幸男, 大平 雅一, 石川 哲郎, 池原 照幸, 平川 弘聖

    日本外科学会雑誌   113 ( 臨増2 )   528 - 528   2012.03( ISSN:0301-4894

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  • 外科的切除を行なったstage IV胃癌患者の予後因子の検討

    久保 尚士, 櫻井 克宣, 田中 浩明, 六車 一哉, 八代 正和, 澤田 鉄二, 山下 好人, 永原 央, 木村 健二郎, 天野 良亮, 野田 英児, 高島 勉, 山田 靖哉, 小野田 尚佳, 仲田 文造, 大平 雅一, 石川 哲郎, 平川 弘聖

    日本外科学会雑誌   113 ( 臨増2 )   510 - 510   2012.03( ISSN:0301-4894

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  • 【外科系各科におけるがん免疫療法】スキルス胃癌に対するペプチドワクチン療法 新規エピトープペプチドの同定 Reviewed

    田中 浩明, 岩内 武彦, 六車 一哉, 吉井 真美, 久保 尚士, 八代 正和, 澤田 鉄二, 大平 雅一, 平川 弘聖

    日本外科系連合学会誌   37 ( 1 )   36 - 40   2012.02( ISSN:0385-7883

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    スキルス胃癌は,高率にリンパ節転移や腹膜播種転移をきたす予後不良な疾患であり,現在の外科治療,化学療法では有効性が未だ不十分である.癌に対するワクチン療法は,副作用がない安全な治療法であり,各種癌腫に対する臨床試験が進みその有効性が示されつつある.ワクチン療法の効果を上げるためには,強い免疫原性を有する癌拒絶抗原の同定が必須である.今回の研究では,スキルス胃癌におけるES細胞の腫瘍形成に関与するERasの発現を検討し,HLA-A*2402拘束性ペプチドの同定を試みた.スキルス胃癌においてERasは26%の症例に発現を認めた.ERas蛋白由来の9merのペプチド(FALDDPSSL)により誘導された細胞傷害性T細胞(CTL)は,ERasを内在性に発現している癌細胞株に対してHLA拘束性に細胞傷害効果を示した.つまり,ERasはスキルス胃癌において癌抗原となり,ペプチドワクチン療法に応用できる可能性が示唆された.(著者抄録)

  • 乳癌術前化学療法効果予測における癌幹細胞マーカーCD133の意義

    青松 直撥, 八代 正和, 森崎 珠美, 福岡 達成, 平川 俊基, 長谷川 毅, 松岡 順子, 柏木 伸一郎, 高島 勉, 川尻 成美, 小野田 尚佳, 石川 哲郎, 平川 弘聖

    日本分子腫瘍マーカー研究会誌   27   51 - 51   2012.02

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  • 【外科医のための消化器内視鏡Up-to-Date】各論 消化器内視鏡の診断と外科治療への応用 十二指腸・小腸(ダブルバルーン内視鏡) Reviewed

    野田 英児, 前田 清, 永原 央, 木村 健二郎, 天野 良亮, 久保 尚士, 田中 浩明, 六車 一哉, 山田 靖哉, 八代 正和, 仲田 文造, 大平 雅一, 石川 哲朗, 平川 弘聖

    臨床外科   66 ( 13 )   1610 - 1613   2011.12( ISSN:0386-9857

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    <ポイント>◆ダブルバルーン小腸内視鏡(DBE)の開発によって,小腸造影検査やCT,MRIでは診断が困難であった小腸病変を診断することが可能となった.◆診断,治療のみならず,病変部などへのマーキングが可能である.このことは,手術において非常に有用である.◆偶発症として誤嚥,穿孔,膵炎などが低頻度ではあるがみられるため,外科と内科の連携が重要である.(著者抄録)

  • 【緊急手術の適応と手術手技の実際】腸閉塞 Reviewed

    野田 英児, 前田 清, 永原 央, 天野 良亮, 久保 尚士, 田中 浩明, 六車 一哉, 山田 靖哉, 八代 正和, 大平 雅一, 石川 哲郎, 平川 弘聖

    消化器外科   34 ( 11 )   1649 - 1655   2011.10( ISSN:0387-2645

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  • ALDH1+スキルス胃癌幹細胞の解析(Cancer-initiating cell population in diffuse-type gastric carcinoma cells has high ALDH1 activity)

    勝野 蓉子, 江幡 正悟, 八代 正和, 柳原 五吉, 平川 弘聖, 宮園 浩平

    日本癌学会総会記事   70回   426 - 427   2011.09( ISSN:0546-0476

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  • CD133発現は、乳癌NAC効果予測マーカーとして有用である

    青松 直撥, 八代 正和, 柏木 伸一郎, 高島 勉, 川尻 成美, 小野田 尚佳, 石川 哲郎, 平川 弘聖

    日本乳癌学会総会プログラム抄録集   19回   226 - 226   2011.09

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  • トリプルネガティブ乳癌におけるc-metを分子標的とした治療戦略

    柏木 伸一郎, 八代 正和, 高島 勉, 小川 佳成, 青松 直撥, 川尻 成美, 池田 克実, 小野田 尚佳, 石川 哲郎, 平川 弘聖

    日本乳癌学会総会プログラム抄録集   19回   244 - 244   2011.09

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  • 乳癌術前化学療法効果予測における癌幹細胞マーカーCD133の意義

    青松 直撥, 八代 正和, 森崎 珠美, 福岡 達成, 平川 俊基, 長谷川 毅, 松岡 順子, 柏木 伸一郎, 高島 勉, 川尻 成美, 小野田 尚佳, 石川 哲郎, 平川 弘聖

    日本分子腫瘍マーカー研究会プログラム・講演抄録   31回   74 - 74   2011.09

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  • 乳癌術前化学療法効果予測におけるCD133の意義(Significance of CD 133 for predictive maker in neoadjuvant chemotherapy of breast cancer)

    青松 直撥, 八代 正和, 柏木 伸一郎, 高島 勉, 川尻 成美, 小野田 尚佳, 石川 哲郎, 平川 弘聖

    日本癌学会総会記事   70回   168 - 168   2011.09( ISSN:0546-0476

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  • 乳癌術前化学療法(NAC)効果・予後予測因子としてのCarbonic anhydrase 9の有用性

    青松 直撥, 八代 正和, 柏木 伸一郎, 高島 勉, 川尻 成美, 小野田 尚佳, 石川 哲郎, 平川 弘聖

    日本癌治療学会誌   46 ( 2 )   529 - 529   2011.09( ISSN:0021-4671

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  • 乳癌組織生検における捺印細胞診の有用性

    平川 俊基, 柏木 伸一郎, 小野田 尚佳, 青松 直撥, 川尻 成美, 高島 勉, 八代 正和, 石川 哲郎, 平川 弘聖

    日本乳癌学会総会プログラム抄録集   19回   224 - 224   2011.09

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  • ヒトスキルス胃癌においてBMP-2/4は腫瘍抑制因子として作用する(Bone morphogenetic protein-2/4 play tumor suppressive roles in human diffuse-type gastric carcinoma)

    白井 陽太郎, 江幡 正悟, 八代 正和, 柳原 五吉, 平川 弘聖, 宮園 浩平

    日本癌学会総会記事   70回   421 - 421   2011.09( ISSN:0546-0476

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  • 【がん患者の周術期管理のすべて】術後の主な合併症とその対策 縫合不全、吻合部通過障害 Reviewed

    櫻井 克宣, 六車 一哉, 久保 尚士, 田中 浩明, 八代 正和, 澤田 鉄二, 大平 雅一, 平川 弘聖

    外科治療   104 ( 増刊 )   750 - 755   2011.06( ISSN:0433-2644

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    手術器具や周術期管理の進歩によって術後合併症は減少しつつある。しかし、縫合不全や吻合部通過障害は、一定の頻度で発症する。これら合併症の発症を予防するためには術前から患者の全身状態を把握し、管理することが重要である。起こってしまった合併症については対応が遅れると、重篤化するため、早期発見と治療が重要である。今回、縫合不全と吻合部通過障害に対する予防と対策について胃切除術を中心に解説する。(著者抄録)

  • 食道鏡視下手術の工夫 ベットローテーションを利用した半腹臥位胸腔鏡下食道切除術

    久保 尚士, 中村 雅憲, 李 友浩, 櫻井 克宣, 森本 純也, 永原 央, 天野 良亮, 野田 英児, 田中 浩明, 六車 一哉, 高島 勉, 山田 靖哉, 山下 好人, 八代 正和, 仲田 文造, 前田 清, 小野田 尚佳, 澤田 鉄二, 大平 雅一, 石川 哲郎, 平川 弘聖

    日本外科学会雑誌   112 ( 臨増1-2 )   304 - 304   2011.05( ISSN:0301-4894

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  • NAC効果予測マーカーとしての癌細胞E-cadherin発現の有用性

    青松 直撥, 八代 正和, 柏木 伸一郎, 高島 勉, 吉井 真美, 平川 俊基, 松岡 順子, 加藤 幸裕, 冬廣 雄彦, 川尻 成美, 小野田 尚佳, 石川 哲郎, 平川 弘聖

    日本外科学会雑誌   112 ( 臨増1-2 )   704 - 704   2011.05( ISSN:0301-4894

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  • Is E-cadherin a useful surrogate marker to predict chemosensitivity of chemotherapy for triple-negative breast cancer?

    S. Kashiwagi, M. Yashiro, T. Takashima, N. Aomatsu, H. Kawajiri, N. Onoda, B. Nakata, T. Ishikawa, K. Hirakawa

    JOURNAL OF CLINICAL ONCOLOGY   29 ( 15 )   2011.05( ISSN:0732-183X ( eISSN:1527-7755

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  • IPMNをめぐる諸問題 診断から治療まで 膵管内乳頭粘液性腫瘍(IPMN)の亜型分類と悪性度の検討

    大平 豪, 山田 靖哉, 天野 良亮, 木村 健二郎, 村田 哲洋, 中本 健太郎, 永原 央, 野田 英児, 久保 尚士, 田中 浩明, 六車 一哉, 高島 勉, 八代 正和, 小野田 尚佳, 前田 清, 澤田 鉄二, 仲田 文造, 大平 雅一, 石川 哲郎, 平川 弘聖

    日本外科学会雑誌   112 ( 臨増1-2 )   231 - 231   2011.05( ISSN:0301-4894

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  • circular staplerを用いた安全かつ簡便な腹腔鏡下食道・空腸吻合術

    櫻井 克宣, 六車 一哉, 永原 央, 天野 良亮, 野田 英児, 久保 尚士, 田中 浩明, 山田 靖哉, 八代 正和, 前田 清, 小野田 尚佳, 澤田 鉄二, 仲田 文造, 大平 雅一, 石川 哲郎, 平川 弘聖

    日本外科学会雑誌   112 ( 臨増1-2 )   597 - 597   2011.05( ISSN:0301-4894

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  • トリプルネガティブ乳癌における化学療法感受性マーカーとしてのE-cadherin/Ki67発現

    柏木 伸一郎, 八代 正和, 高島 勉, 青松 直撥, 川尻 成実, 池田 克実, 小川 佳成, 小野田 尚佳, 石川 哲郎, 平川 弘聖

    日本外科学会雑誌   112 ( 臨増1-2 )   447 - 447   2011.05( ISSN:0301-4894

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  • 切除不能遠隔転移を有する大腸癌の原発巣非切除例に対する化学療法

    野田 英児, 前田 清, 永原 央, 井上 透, 中本 健太郎, 天野 良亮, 久保 尚士, 田中 浩明, 六車 一哉, 八代 正和, 山田 靖哉, 澤田 鉄二, 仲田 文造, 高島 勉, 小野田 尚佳, 西口 幸雄, 大平 雅一, 石川 哲郎, 池原 照幸, 平川 弘聖

    日本外科学会雑誌   112 ( 臨増1-2 )   668 - 668   2011.05( ISSN:0301-4894

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  • 胃癌術後におけるPSK併用補助免疫化学療法の効果

    田中 浩明, 六車 一哉, 久保 尚士, 澤田 鉄二, 大平 雅一, 木村 健二郎, 永原 央, 天野 良亮, 野田 英児, 山田 靖哉, 八代 正和, 小野田 尚佳, 前田 清, 仲田 文造, 石川 哲郎, 平川 弘聖

    日本外科学会雑誌   112 ( 臨増1-2 )   659 - 659   2011.05( ISSN:0301-4894

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  • 腹腔鏡下胃切除術における視野展開の工夫 Reviewed

    六車 一哉, 大平 雅一, 田中 浩明, 久保 尚士, 八代 正和, 山田 靖哉, 山下 好人, 澤田 鉄二, 平川 弘聖

    外科治療   104 ( 4 )   392 - 396   2011.04( ISSN:0433-2644

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    腹腔鏡手術の最大のメリットは、拡大視効果による微細な局所解剖の描出によって、より精緻な手術が可能になることである。しかしながら、それは良好な視野展開がなされて初めて成立するものである。胃小彎側のリンパ節郭清時にはしばしば肝左葉が視野の妨げとなり、これまでさまざまな視野展開の工夫が報告されている。今回、当科で施行している腹腔鏡下胃切除術における視野展開(肝挙上)の工夫につき報告する。(著者抄録)

  • Clinical significance of HER3 expression in curatively resected pancreatic cancer

    Toshiki Hirakawa, Bunzo Nakata, Shinichiro Kashiwagi, Yukihiro Kato, Yuhiko Fuyuhiro, Takehiko Iwauchi, Junko Matsusoka, Gentaro Itoh, Naoki Aomatsu, Mami Yoshii, Tsuyoshi Hasegawa, Ryosuke Amano, Naoshi Kubo, Hiroaki Tanaka, Kazuya Muguruma, Nobuya Yamada, Masakazu Yashiro, Tetsuji Sawada, Masaichi Ohira, Kosei Hirakawa

    CANCER RESEARCH   71   2011.04( ISSN:0008-5472 ( eISSN:1538-7445

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    DOI: 10.1158/1538-7445.AM2011-2265

  • Impact of histological types on infiltration of regulatory T cells in gastric cancer

    Mami Yoshii, Hiroaki Tanaka, Katsunobu Sakurai, Hisashi Nagahara, Kenjirou Kimura, Ryousuke Amano, Eiji Noda, Naoshi Kubo, Kazuya Muguruma, Nobuya Yamada, Masakazu Yashiro, Kiyoshi Maeda, Tetsuji Sawada, Masaichi Ohira, Tetsurou Ishikawa, Kosei Hirakawa

    CANCER RESEARCH   71   2011.04( ISSN:0008-5472 ( eISSN:1538-7445

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    DOI: 10.1158/1538-7445.AM2011-796

  • Effect of cancer-associated fibroblast on the progression of gastric cancer stem cells

    Tsuyoshi Hasegawa, Masakazu Yashiro, Junko Matsuoka, Shinichiro Kashiwagi, Yuhiko Fuyuhiro, Katsunobu Sakurai, Katsunobu Sakurai, Naoshi Kubo, Hiroaki Tanaka, Kazuya Muguruma, Nobuya Yamada, Nobuya Yamada, Kiyoshi Maeda, Masaichi Ohira, Tetsuro Ishikawa, Kosei Hirakawa

    CANCER RESEARCH   71   2011.04( ISSN:0008-5472 ( eISSN:1538-7445

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    DOI: 10.1158/1538-7445.AM2011-5200

  • Direct inhibitory effects of gastric cancer against dendritic cells

    Takehiko Iwauchi, Hiroaki Tanaka, Mami Yoshii, Gentaro Ito, Kenjiro Kimura, Hisashi Nagahara, Eiji Noda, Ryosuke Amano, Naoshi Kubo, Kazuya Muguruma, Nobuya Yamada, Masakazu Yashiro, Kiyoshi Maeda, Masaichi Ohira, Kosei Hirakawa

    CANCER RESEARCH   71   2011.04( ISSN:0008-5472 ( eISSN:1538-7445

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    DOI: 10.1158/1538-7445.AM2011-793

  • Synergistic antitumor effects of FGFR2 inhibitor with 5-fluorouracil on diffuse-type gastric carcinoma

    Masakazu Yashiro, Osamu Shinto, Kazunori Nakamura, Masashige Tendo, Tasuku Matsuoka, Taro Matsuzaki, Ryoji Kaizaki, Atsushi Miwa, Kosei Hirakawa

    CANCER RESEARCH   71   2011.04( ISSN:0008-5472 ( eISSN:1538-7445

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    DOI: 10.1158/1538-7445.AM2011-2552

  • The effect of synergic anti-proliferation of DNA methyltransferase inhibitor binding to anti-cancer drugs in gastric cancer

    Kazuya Muguruma, Masakazu Yashiro, Hiroaki Tanaka, Kenjirou Kimura, Hisashi Nagahara, Ryousuke Amano, Eiji Noda, Naoshi Kubo, Nobuya Yamada, Kiyoshi Maeda, Masaichi Ohira, Tetsurou Ishikawa, Kosei Hirakawa

    CANCER RESEARCH   71   2011.04( ISSN:0008-5472 ( eISSN:1538-7445

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    DOI: 10.1158/1538-7445.AM2011-100

  • 【外科医に必要な輸血の知識】自己血輸血の実際 食道癌手術における自己血輸血の現況 Reviewed

    久保 尚士, 田中 浩明, 山下 好人, 六車 一哉, 八代 正和, 大平 雅一, 平川 弘聖

    外科治療   104 ( 3 )   235 - 240   2011.03( ISSN:0433-2644

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    同種血輸血はアレルギー反応、輸血感染症、移植片対宿主病などの副作用が起こることがあり、免疫能の低下を引き起こすなどの報告もみられる。自己血輸血は、同種血輸血の副作用を回避しうる最も安全な輸血療法である。当科では2000年以降の食道癌手術患者にエリスロポイエチンを併用した自己血輸血療法を導入し、同種血輸血をできる限り回避してきた。自己血輸血導入当初は同種血輸血回避率41%(9/22)であったが、2005年には84%(21/25)と有意に上昇していた。また同種血輸血群58例と自己血輸血群99例の患者背景、臨床因子を比較すると同種血輸血群が有意に高齢、術前治療例が多く、術中出血量が多かった。(著者抄録)

  • びまん性胃癌 進行、血管新生、TGF-βシグナル伝達(Diffuse-Type Gastric Carcinoma: Progression, Angiogenesis and TGF-β Signaling)

    古室 暁義, 八代 正和, 岩田 要, 森下 保幸, Johansson Erik, 松元 芳子, 渡辺 亮, 油谷 浩之, 三好 弘之, 清野 邦彦, 白井 陽太郎, 鈴木 洋, 平川 弘聖, 狩野 光伸, 宮園 浩平

    日本病理学会会誌   100 ( 1 )   457 - 457   2011.03( ISSN:0300-9181

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  • 低酸素環境が胃癌細胞の放射線感受性におよぼす影響

    加藤 幸裕, 八代 正和, 木村 健二郎, 永原 央, 天野 良亮, 野田 英児, 久保 尚士, 田中 浩明, 六車 一哉, 山田 靖哉, 小野田 尚佳, 前田 清, 大平 雅一, 石川 哲郎, 平川 弘聖

    日本胃癌学会総会記事   83回   285 - 285   2011.03

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  • スキルス胃癌幹細胞に対するTGF-βの機能解析

    江幡 正悟, Johansson Erik, 片山 量平, 小池 清恵, 渡辺 亮, 星野 佑香梨, 勝野 蓉子, 古室 暁義, 鯉沼 代造, 狩野 光伸, 八代 正和, 平川 弘聖, 油谷 浩幸, 藤田 直也, 宮園 浩平

    日本病理学会会誌   100 ( 1 )   457 - 457   2011.03( ISSN:0300-9181

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  • E-cadherinとKi67はトリプルネガティブ乳癌の化学療法感受性に有用なマーカーである

    柏木 伸一郎, 八代 正和, 高島 勉, 川尻 成美, 池田 克実, 小川 佳成, 小野田 尚佳, 石川 哲郎, 平川 弘聖

    日本分子腫瘍マーカー研究会誌   26   55 - 56   2011.01

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  • 胃癌組織における低酸素マーカーCarbonic Anhydrase-9の臨床病理学的意義

    加藤 幸裕, 八代 正和, 久保 尚士, 田中 浩明, 六車 一哉, 前田 清, 小野田 尚佳, 石川 哲郎, 平川 弘聖

    日本分子腫瘍マーカー研究会誌   26   66 - 67   2011.01

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  • 【リンパ節郭清 最近のコンセプト】胃癌に対するリンパ節郭清 Reviewed

    六車 一哉, 大平 雅一, 田中 浩明, 久保 尚士, 山田 靖哉, 八代 正和, 澤田 鉄二, 仲田 文造, 石川 哲郎, 平川 弘聖

    消化器外科   33 ( 13 )   1941 - 1952   2010.12( ISSN:0387-2645

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  • 進行肝細胞癌に対するソラフェニブの治療成績

    天野 良亮, 山田 靖哉, 野田 英児, 久保 尚士, 田中 浩明, 六車 一哉, 高島 勉, 八代 正和, 前田 清, 小野田 尚佳, 澤田 鉄二, 仲田 文造, 大平 雅一, 石川 哲郎, 平川 弘聖

    癌と化学療法   37 ( 12 )   2676 - 2678   2010.11( ISSN:0385-0684

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    肝外病変を伴う進行肝細胞癌に対するソラフェニブの治療成績を検討した。対象は2009年6〜10月までに当科でソラフェニブを投与した進行肝細胞癌8例。有害事象は7例(87.5%)に認め、grade 3以上は手足症候群2例、疲労1例であった。その他にgrade 2の高血圧3例、grade 1の下痢2例、食欲不振4例を認めた。減量投与移行は3例、休薬は2例に行ったが全症例継続投与可能であった。治療効果はCR/PR0例、SD2例、PD6例、予後はソラフェニブ投与開始からは101日であった。8例中6例が原病死しており、現在2例が継続投与中である。現時点での進行肝細胞癌に対するソラフェニブの治療成績は満足できるものではなかった。高率に有害事象を認めるが、減量・休薬による投与法の工夫によって継続投与は可能であった。(著者抄録)

  • ANTI-TUMOR EFFECT OF LAPATINIB PLUS S-1 AGAINST PANCREATIC CANCER

    Bunzo Nakata, Masahiro Komoto, Tsutomu Takashima, Ryosuke Amano, Nobuya Yamada, Taeko Nakano, Masakazu Yashiro, Kosei Hirakawa

    ANNALS OF ONCOLOGY   21   19 - 19   2010.11( ISSN:0923-7534

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  • 局所進行再発食道癌に対するDocetaxel併用化学放射線療法

    久保 尚士, 森本 純也, 櫻井 克宣, 田中 浩明, 六車 一哉, 天野 良亮, 野田 英児, 永原 央, 高島 勉, 八代 正和, 山田 靖哉, 小野田 尚佳, 前田 清, 澤田 鉄二, 仲田 文造, 大平 雅一, 石川 哲郎, 平川 弘聖

    癌と化学療法   37 ( 12 )   2261 - 2263   2010.11( ISSN:0385-0684

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    docetaxel(DOC)は外来投与が可能で、放射線の増感作用を有する新規抗癌剤である。今回、われわれは進行再発食道癌8例に対してDOC併用化学放射線療法(CRT)を施行したのでその効果と安全性を報告する。対象と方法:対象は縦隔リンパ節再発6例、併存疾患による手術不能例1例、FP療法後の二次治療が1例であった。DOCは10mg/m2を週1回×6週点滴投与、放射線は2Gy/回計60Gyを照射した。結果:効果判定はCR2例、PR5例、SD1例で奏効率87.5%であった。有害事象はgrade 3以上の血液毒性、grade 2以上の非血液毒性ともに認められず、経口摂取ができなかった1例以外は全例が外来にて治療可能であった。平均奏効期間は6.6ヵ月、生存期間中央値は13.3ヵ月であった。まとめ:局所進行再発食道癌に対するDOC-CRTは高い奏効率を認め、患者の生活の質を維持できる優れた治療と考えられた。(著者抄録)

  • 胃切除7年8ヵ月後に腹膜播種にて再発したCY陽性4型胃癌の1例

    中村 雅憲, 久保 尚士, 森本 純也, 田中 浩明, 六車 一哉, 天野 良亮, 野田 英児, 井上 透, 高島 勉, 山田 靖哉, 八代 正和, 山下 好人, 前田 清, 小野田 尚佳, 澤田 鉄二, 仲田 文造, 大平 雅一, 石川 哲郎, 平川 弘聖

    癌と化学療法   37 ( 12 )   2436 - 2438   2010.11( ISSN:0385-0684

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    症例は55歳、女性。食思不振、体重減少を主訴に来院。上部消化管内視鏡検査にて胃粘膜の浮腫性変化とgiant foldを認め、生検にて低分化型腺癌と診断された。腹部CT検査では腹水や肝転移は認めなかったが、胃壁の肥厚と多数のリンパ節腫大を指摘された。術前診断T3N2M0、Stage IIIBの4型胃癌と診断し、胃全摘術を施行した。明らかな腹膜播種は認めなかったものの、腹腔洗浄細胞診が陽性であった。術後はS-1単剤による補助療法を4年間行い、再発は認めなかった。しかし7年8ヵ月後にCT検査にて腹膜播種再発と診断され、現在再度S-1にて治療中である。(著者抄録)

  • 【今日の未分化胃癌(sig、por)の治療】未分化型胃癌の特性と自然史 Reviewed

    八代 正和, 六車 一哉, 平川 弘聖

    外科治療   103 ( 4 )   325 - 332   2010.10( ISSN:0433-2644

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    胃癌の組織像は腺管形成能により分化型と未分化型に分類される。未分化型は若年女性、3型や4型、深達度se、INF-cに多く、また腹膜転移やリンパ節転移しやすい。未分化型は予後不良であるが独立した予後因子ではない。分化型は腸上皮化生粘膜を母地として、未分化型は固有胃粘膜を母地として発生する。分化型腺癌として発生し進行とともに未分化型へと変化するタイプが存在する。癌細胞と周囲間質細胞との相互作用は胃癌組織形成に関連する。(著者抄録)

  • VATSで根治切除しえた食道悪性黒色腫の1例

    倉田 研人, 田中 浩明, 久保 尚士, 六車 一哉, 村田 哲洋, 永原 央, 天野 良亮, 野田 英児, 山田 靖哉, 八代 正和, 前田 清, 小野田 尚佳, 石川 哲郎, 大平 雅一, 平川 弘聖

    日本臨床外科学会雑誌   71 ( 増刊 )   955 - 955   2010.10( ISSN:1345-2843

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  • Characteristics and natural history of undifferentiated-type gastric carcinoma Reviewed

    103 ( 4 )   325 - 332   2010.10( ISSN:0433-2644

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    CiNii Article

    Other URL: http://search.jamas.or.jp/link/ui/2011006707

  • 悪性リンパ腫の診断に対する超音波ガイド下携帯型吸引式リンパ節生検の有用性の検討

    柏木 伸一郎, 小野田 尚佳, 青松 直撥, 川尻 成美, 高島 勉, 八代 正和, 仲田 文造, 石川 哲郎, 平川 弘聖

    日本臨床外科学会雑誌   71 ( 増刊 )   691 - 691   2010.10( ISSN:1345-2843

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  • E-cadherinとKi67はトリプルネガティブ乳癌の化学療法感受性に有用なマーカーである

    柏木 伸一郎, 八代 正和, 高島 勉, 川尻 成美, 池田 克実, 小川 佳成, 小野田 尚佳, 石川 哲郎, 平川 弘聖

    日本分子腫瘍マーカー研究会プログラム・講演抄録   30回   75 - 76   2010.09

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  • Triple negative乳がんの特徴と治療戦略 Triple-negative乳癌の術前・術後化学療法の効果予測因子としてのE-cadherinの有用性

    柏木 伸一郎, 八代 正和, 高島 勉, 川尻 成美, 池田 克実, 小川 佳成, 小野田 尚佳, 石川 哲郎, 平川 弘聖

    日本癌治療学会誌   45 ( 2 )   343 - 343   2010.09( ISSN:0021-4671

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  • 胃癌組織における低酸素マーカーCarbonic Anhydrase-9の臨床病理学的意義

    加藤 幸裕, 八代 正和, 久保 尚士, 田中 浩明, 六車 一哉, 前田 清, 小野田 尚佳, 石川 哲郎, 平川 弘聖

    日本分子腫瘍マーカー研究会プログラム・講演抄録   30回   86 - 87   2010.09

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  • TGF-betaは胃癌のSP細胞を減らし、腫瘍形成能を減弱させる(TGF-beta diminishes the SP fraction of the diffuse-type gastric cancer cells)

    江幡 正悟, 片山 量平, 小池 清恵, 渡辺 亮, 星野 佑香梨, 勝野 蓉子, 鯉沼 代造, 狩野 光伸, 八代 正和, 平川 弘聖, 油谷 浩幸, 藤田 直也, 宮園 浩平

    日本癌学会総会記事   69回   229 - 230   2010.08( ISSN:0546-0476

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  • 低酸素耐性スキルス胃癌細胞株OCUM-12/Hypoの特性(Characterization of a hypoxia-resistant cancer cell line, OCUM-12/Hypo, derived from a scirrhous gastric carcinoma)

    加藤 幸裕, 八代 正和, 久保 尚士, 田中 浩明, 六車 一哉, 前田 清, 小野田 尚佳, 澤田 鉄二, 大平 雅一, 石川 哲郎, 平川 弘聖

    日本癌学会総会記事   69回   506 - 506   2010.08( ISSN:0546-0476

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  • トリプルネガティブ乳癌における治療効果予測因子としてのE-cadherin発現(Significance of E-cadherin and Ki67 as a chemo-sensitivity marker in triple-negative breast cancer)

    柏木 伸一郎, 八代 正和, 高島 勉, 松岡 順子, 加藤 幸裕, 冬廣 雄彦, 川尻 成美, 小野田 尚佳, 石川 哲郎, 平川 弘聖

    日本癌学会総会記事   69回   460 - 460   2010.08( ISSN:0546-0476

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  • トリプルネガティブ乳癌における低酸素状態の臨床病理学的意義(Significance of hypoxic marker carbonic anhydrase 9 in triple-negative breast cancer)

    青松 直撥, 八代 正和, 柏木 伸一郎, 高島 勉, 松岡 順子, 加藤 幸裕, 冬廣 雄彦, 川尻 成美, 小野田 尚佳, 石川 哲郎, 平川 弘聖

    日本癌学会総会記事   69回   500 - 500   2010.08( ISSN:0546-0476

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  • スキルス胃癌幹細胞は高いALDH1酵素活性を示す(Cancer-initiating cell population in diffuse-type gastric carcinoma cells has high ALDH1 activity)

    勝野 蓉子, 江幡 正悟, 八代 正和, 平川 弘聖, 宮園 浩平

    日本癌学会総会記事   69回   229 - 229   2010.08( ISSN:0546-0476

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  • スキルス胃癌の進展においてBMPは腫瘍増殖抑制因子として作用する(BMP plays a tumor suppressive role in diffuse-type gastric carcinoma development)

    白井 陽太郎, 江幡 正悟, 八代 正和, 平川 弘聖, 宮園 浩平

    日本癌学会総会記事   69回   41 - 41   2010.08( ISSN:0546-0476

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  • スキルス胃がん腹膜播種へのREIC/Dkk-3遺伝子治療の効果(REIC/Dkk-3 gene therapy suppresses peritoneal dissemination of scirrhous gastric carcinoma)

    片岡 健, タン・スエスエ, 阪口 政清, アバルスァ・フェルナンド, 村田 等, 八代 正和, 那須 保友, 公文 裕巳, 許 南浩

    日本癌学会総会記事   69回   252 - 253   2010.08( ISSN:0546-0476

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  • スキルス胃癌細胞と筋線維芽細胞発現の検討

    冬廣 雄彦, 八代 正和, 久保 尚士, 田中 浩明, 六車 一哉, 井上 透, 前田 清, 小野田 尚佳, 石川 哲郎, 平川 弘聖

    日本消化器外科学会総会   65回   338 - 338   2010.07

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  • 低酸素耐性スキルス胃癌細胞株OCUM-12/Hypoの樹立とその特性

    加藤 幸裕, 八代 正和, 久保 尚士, 田中 浩明, 六車 一哉, 井上 透, 前田 清, 小野田 尚佳, 石川 哲郎, 平川 弘聖

    日本消化器外科学会総会   65回   341 - 341   2010.07

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  • 消化器癌転移のメカニズムに基づいた新たな治療標的分子の探索 低酸素環境におけるスキルス胃癌細胞の腹膜転移機序と分子標的治療

    野田 諭, 八代 正和, 久保 尚士, 田中 浩明, 六車 一哉, 井上 透, 小野田 尚佳, 前田 清, 石川 哲郎, 平川 弘聖

    日本消化器外科学会総会   65回   72 - 72   2010.07

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  • スキルス胃癌 Reviewed

    八代 正和

    消化器の臨床   13 ( 3 )   233 - 239   2010.06( ISSN:1344-3070

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    スキルス胃癌は、術後5年生存率が10%程度と治療成績不良である。胃造影検査や内視鏡検査で胃底腺領域のIIc様陥凹や胃壁硬化の観察が重要である。胃全摘術施行例が多いが、術中洗浄細胞診陽性(CY1)あるいは腹膜転移陽性のために非根治術となる例が半数を超える。同じCY1症例でもスキルス胃癌は他型胃癌に比べ予後不良である。粘膜内で発生した癌細胞にFGFR2やTGFβRが発現していると線維芽細胞との相互作用が連鎖的に招来され、スキルス胃癌が成立する。FGFR2やTGFβRシグナルの阻害剤はスキルス胃癌治療に有用である。(著者抄録)

  • 食道癌、大腸癌におけるVitamin D Receptor発現の意義

    田中 浩明, 天野 良亮, 野田 英児, 久保 尚士, 六車 一哉, 井上 透, 八代 正和, 山田 靖哉, 前田 清, 澤田 鉄二, 小野田 尚佳, 仲田 文造, 石川 哲郎, 大平 雅一, 平川 弘聖

    日本外科系連合学会誌   35 ( 3 )   487 - 487   2010.05( ISSN:0385-7883

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  • E-cadherin発現はトリプルネガティブ乳癌の抗癌剤感受性マーカーとして有用である

    柏木 伸一郎, 八代 正和, 高島 勉, 小川 佳成, 野田 諭, 川尻 成美, 池田 克実, 小野田 尚佳, 石川 哲郎, 平川 弘聖

    日本乳癌学会総会プログラム抄録集   18回   450 - 450   2010.05

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  • 若年男性に発生したSPN(Solid-pseudopapillary neoplasm)の1例

    大平 豪, 山田 靖哉, 天野 良亮, 中本 健太郎, 土井 洋輔, 野田 英児, 久保 尚士, 田中 浩明, 六車 一哉, 井上 透, 高島 勉, 八代 正和, 前田 清, 小野田 尚佳, 澤田 鉄二, 仲田 文造, 大平 雅一, 石川 哲郎, 平川 弘聖, 桑江 優子, 若狭 研一

    日本肝胆膵外科学会・学術集会プログラム・抄録集   22回   364 - 364   2010.05

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  • 膵内分泌腫瘍診療の進歩 膵内分泌腫瘍の治療戦略

    天野 良亮, 山田 靖哉, 野田 英児, 久保 尚士, 田中 浩明, 六車 一哉, 高島 勉, 八代 正和, 小野田 尚佳, 前田 清, 澤田 鉄二, 仲田 文造, 大平 雅一, 石川 哲郎, 平川 弘聖

    日本内分泌外科学会総会プログラム・抄録集   22回   79 - 79   2010.04

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  • Cancer-associated myofibroblast may stimulate vimentin expression of gastric cancer cells

    Fuyuhiro Yuhiko, Masakazu Yashiro, Satoru Noda, Yosuke Doi, Yukihiro Kato, Shinichiro Kashiwagi, Naoshi Kubo, Hiroaki Tanaka, Kazuya Mugurunna, Toru Inoue, Nobuya Yamada, Masaichi Ohira, Kosei Hirakawa

    CANCER RESEARCH   70   2010.04( ISSN:0008-5472 ( eISSN:1538-7445

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    DOI: 10.1158/1538-7445.AM10-1003

  • 難治性内分泌癌(甲状腺未分化癌、再発甲状腺分化癌、副腎癌、Neuroendocrine tumor)の治療戦略 オクトレオチドによる膵消化管内分泌腫瘍の治療戦略

    天野 良亮, 山田 靖哉, 大平 豪, 中本 健太郎, 土井 洋輔, 岩内 武彦, 野田 英児, 久保 尚士, 田中 浩明, 六車 一哉, 井上 透, 高島 勉, 八代 正和, 小野田 尚佳, 前田 清, 澤田 鉄二, 仲田 文造, 大平 雅一, 石川 哲郎, 平川 弘聖

    日本外科学会雑誌   111 ( 臨増2 )   165 - 165   2010.03( ISSN:0301-4894

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  • cStageII、III食道癌切除症例におけるリンパ節内微小転移の検出と再発との関連について

    森本 純也, 田中 浩明, 久保 尚士, 六車 一哉, 山添 定明, 岩内 武彦, 伊藤 厳太郎, 河本 真大, 永原 央, 天野 良亮, 野田 英児, 井上 透, 山田 靖哉, 八代 正和, 小野田 尚佳, 仲田 文造, 前田 清, 澤田 鉄二, 大平 雅一, 石川 哲郎, 平川 弘聖

    日本外科学会雑誌   111 ( 臨増2 )   602 - 602   2010.03( ISSN:0301-4894

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  • 膵癌に対するS-1+lapatinib併用療法の基礎的検討

    河本 真大, 仲田 文造, 天野 良亮, 野田 英児, 久保 尚士, 田中 浩明, 六車 一哉, 井上 透, 高島 勉, 山田 靖哉, 八代 正和, 前田 清, 小野田 尚佳, 澤田 鉄二, 大平 雅一, 石川 哲郎, 平川 弘聖

    日本外科学会雑誌   111 ( 臨増2 )   668 - 668   2010.03( ISSN:0301-4894

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  • 膵癌細胞に高発現するMUC 5 AC由来HLA-A*0201、A*2402拘束性エピトープペプチドの同定と膵癌に対するペプチドワクチン療法への応用の可能性

    山添 定明, 田中 浩明, 岩内 武彦, 森本 純也, 伊藤 厳太郎, 川尻 成美, 野田 英児, 天野 良亮, 久保 尚士, 六車 一哉, 井上 透, 高島 勉, 山田 靖哉, 八代 正和, 前田 清, 小野田 尚佳, 澤田 鉄二, 仲田 文造, 大平 雅一, 石川 哲郎, 平川 弘聖

    日本外科学会雑誌   111 ( 臨増2 )   196 - 196   2010.03( ISSN:0301-4894

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  • 膵管内乳頭粘液性腫瘍(IPMN)に対する外科的治療成績と手術適応に関する検討

    大平 豪, 山田 靖哉, 天野 良亮, 土井 洋輔, 岩内 武彦, 中本 健太郎, 野田 英児, 久保 尚士, 田中 浩明, 六車 一哉, 高島 勉, 井上 透, 八代 正和, 小野田 尚佳, 前田 清, 澤田 鉄二, 仲田 文造, 大平 雅一, 石川 哲郎, 平川 弘聖

    日本外科学会雑誌   111 ( 臨増2 )   460 - 460   2010.03( ISSN:0301-4894

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  • 術後胃排泄遅延からみた膵頭十二指腸切除術後消化管再建法の検討

    中本 健太郎, 天野 良亮, 山田 靖哉, 大平 豪, 土井 洋輔, 岩内 武彦, 野田 英児, 久保 尚士, 田中 浩明, 六車 一哉, 井上 透, 高島 勉, 八代 正和, 小野田 尚佳, 前田 清, 澤田 鉄二, 仲田 文造, 大平 雅一, 石川 哲郎, 平川 弘聖

    日本外科学会雑誌   111 ( 臨増2 )   701 - 701   2010.03( ISSN:0301-4894

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  • StageIV胃癌に対する外科的手術介入の是非について

    六車 一哉, 澤田 鉄二, 豊川 貴弘, 森本 純也, 野田 英児, 天野 良亮, 久保 尚士, 田中 浩明, 井上 透, 高島 勉, 八代 正和, 山田 靖哉, 山下 好人, 小野田 尚佳, 前田 清, 仲田 文造, 大平 雅一, 石川 哲郎, 平川 弘聖

    日本外科学会雑誌   111 ( 臨増2 )   595 - 595   2010.03( ISSN:0301-4894

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  • 消化器癌腹膜転移の治療 基礎と臨床 胃癌の腹膜播種性転移における低酸素の関与とTGFβR阻害剤の効果

    野田 諭, 八代 正和, 天野 良亮, 野田 英児, 久保 尚士, 田中 浩明, 六車 一哉, 高島 勉, 井上 透, 山田 靖哉, 小野田 尚佳, 前田 清, 澤田 鉄二, 仲田 文造, 大平 雅一, 石川 哲郎, 平川 弘聖

    日本外科学会雑誌   111 ( 臨増2 )   167 - 167   2010.03( ISSN:0301-4894

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  • トリプルネガティブ乳癌におけるE-cadherin発現と予後リスク

    柏木 伸一郎, 八代 正和, 高島 勉, 野田 諭, 川尻 成美, 小野田 尚佳, 仲田 文造, 石川 哲郎, 平川 弘聖

    日本外科学会雑誌   111 ( 臨増2 )   491 - 491   2010.03( ISSN:0301-4894

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  • トリプルネガティブ乳癌におけるE-cadherinの発現低下は予後と相関する

    柏木 伸一郎, 八代 正和, 高島 勉, 野田 諭, 川尻 成美, 小野田 尚佳, 石川 哲郎, 平川 弘聖

    日本分子腫瘍マーカー研究会誌   25   65 - 65   2010.02

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  • 胸部食道癌術後乳縻胸症例の臨床的検討

    森本 純也, 大平 雅一, 久保 尚士, 田中 浩明, 六車 一哉, 天野 良亮, 野田 英児, 井上 透, 山田 靖哉, 八代 正和, 前田 清, 小野田 尚佳, 澤田 鉄二, 石川 哲郎, 山下 好人, 西口 幸雄, 平川 弘聖

    日本腹部救急医学会雑誌   30 ( 2 )   324 - 324   2010.02( ISSN:1340-2242

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  • 膵癌細胞に発現するMUC5ACの機能解析およびHLA-A*0201、A*2402拘束性エピトープペプチドの同定

    山添 定明, 田中 浩明, 岩内 武彦, 天野 良亮, 野田 英児, 久保 尚士, 六車 一哉, 井上 透, 高島 勉, 山田 靖哉, 八代 正和, 前田 清, 小野田 尚佳, 澤田 鉄二, 仲田 文造, 大平 雅一, 石川 哲郎, 平川 弘聖

    Biotherapy   23 ( Suppl.I )   132 - 132   2009.11( ISSN:0914-2223

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  • スキルス胃癌由来のTGFβによる樹状細胞の機能抑制とTGFβ阻害剤による克服

    田中 浩明, 山添 定明, 岩内 武彦, 天野 良亮, 野田 英児, 久保 尚士, 六車 一哉, 井上 透, 山田 靖哉, 八代 正和, 小野田 尚佳, 前田 清, 澤田 鉄二, 仲田 文造, 大平 雅一, 石川 哲郎, 平川 弘聖

    Biotherapy   23 ( Suppl.I )   111 - 111   2009.11( ISSN:0914-2223

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  • 新規胃癌抗原ERasをターゲットとしたHLA-A*2402拘束性エピトープペプチドの同定

    岩内 武彦, 田中 浩明, 山添 定明, 貝崎 亮二, 天野 良亮, 野田 英児, 久保 尚士, 六車 一哉, 井上 透, 高島 勉, 山田 靖哉, 八代 正和, 小野田 尚佳, 前田 清, 澤田 鉄二, 仲田 文造, 大平 雅一, 石川 哲郎, 平川 弘聖

    Biotherapy   23 ( Suppl.I )   130 - 130   2009.11( ISSN:0914-2223

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  • 大腸癌肝転移症例に対するFOLFOXを中心とした術前化学療法の成績

    天野 良亮, 山田 靖哉, 野田 英児, 久保 尚士, 田中 浩明, 六車 一哉, 井上 透, 八代 正和, 前田 清, 小野田 尚佳, 澤田 鉄二, 仲田 文造, 大平 雅一, 石川 哲郎, 平川 弘聖

    癌と化学療法   36 ( 12 )   2003 - 2005   2009.11( ISSN:0385-0684

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    大腸癌肝転移の肝切除例におけるFOLFOX、FOLFIRI術前化学療法症例の治療成績を解析し、その有効性について検討した。対象は当科で術前化学療法としてFOLFOX、FOLFIRIを行った肝切除11症例。術前化学療法のレジメンはFOLFOX 8例、FOLFIRI 3例であった。奏効率は45.5%でPR5例、SD6例であった。術前化学療法前のH因子はH3の2例中1例、H2の3例中2例がダウンステージ可能であった。腫瘍縮小率は平均37.7%であった。肝切除前のICG R15分値は平均13.7%であり、術中・術後合併症は認めなかった。平均観察期間は19.8ヵ月(8〜45ヵ月)であり、現在9例が無再発生存中である。大腸癌肝転移に対するFOLFOXを中心とした術前化学療法は高い腫瘍縮小効果があり、また肝機能を十分に考慮した術式を選択すれば安全に肝切除が行えると考えられた。(著者抄録)

  • 食道胃接合部癌の予後規定因子の解析

    田中 浩明, 大平 雅一, 久保 尚士, 山下 好人, 六車 一哉, 野田 英児, 天野 良亮, 小野田 尚佳, 仲田 文造, 八代 正和, 山田 靖哉, 前田 清, 澤田 鉄二, 石川 哲郎, 平川 弘聖

    日本臨床外科学会雑誌   70 ( 増刊 )   965 - 965   2009.10( ISSN:1345-2843

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  • Doxorubicin/Dacarbazine療法が奏効した家族性大腸腺腫症術後Desmoidの1例

    渡邊 真央, 貝崎 亮二, 前田 清, 永原 央, 野田 英児, 井上 透, 六車 一哉, 山田 靖哉, 小野田 尚佳, 八代 正和, 澤田 鉄二, 大平 雅一, 西口 幸雄, 池原 照幸, 平川 弘聖

    日本臨床外科学会雑誌   70 ( 増刊 )   943 - 943   2009.10( ISSN:1345-2843

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  • PSKと低分子TGFβ阻害剤による癌宿主の免疫寛容克服の可能性

    田中 浩明, 山添 定明, 岩内 武彦, 久保 尚士, 六車 一哉, 井上 透, 山田 靖哉, 八代 正和, 前田 清, 小野田 尚佳, 澤田 鉄二, 仲田 文造, 大平 雅一, 石川 哲郎, 平川 弘聖

    日本癌治療学会誌   44 ( 2 )   783 - 783   2009.09( ISSN:0021-4671

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  • TGF-betaは胃癌のSP細胞画分を減らし、腫瘍形成能を弱める(TGF-beta diminishes the SP fraction of the diffuse-type gastric cancer cells)

    江幡 正悟, 片山 量平, 小池 清恵, 星野 佑香梨, 勝野 蓉子, 狩野 光伸, 八代 正和, 平川 弘聖, 油谷 浩幸, 藤田 直也, 宮園 浩平

    日本癌学会総会記事   68回   275 - 275   2009.08( ISSN:0546-0476

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  • リンパ節転移におけるリンパ洞内皮の形態変化(Microstructural changes of lymphatic endothelium in metastatic lymph node)

    岩田 要, 狩野 光伸, 八代 正和, 平川 弘聖, 宮園 浩平

    日本癌学会総会記事   68回   433 - 433   2009.08( ISSN:0546-0476

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  • トリプルネガティブ乳癌におけるE-cadherin発現(Significance of E-cadherin Expression in Triple-Negative Breast Cancer)

    柏木 伸一郎, 八代 正和, 高島 勉, 野田 諭, 川尻 成美, 小野田 尚佳, 石川 哲郎, 平川 弘聖

    日本癌学会総会記事   68回   58 - 58   2009.08( ISSN:0546-0476

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  • スキルス胃癌幹細胞の同定と解析(Identification and characterization of diffuse-type gastric cancer-initiating cells)

    勝野 蓉子, 江幡 正悟, 八代 正和, 平川 弘聖, 宮園 浩平

    日本癌学会総会記事   68回   236 - 237   2009.08( ISSN:0546-0476

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  • TGFβ阻害剤SB-431542は樹状細胞の成熟化と抗腫瘍免疫を活性化する(TGF-beta inihibitor, induces maturation of dendritic cells and enhances anti-tumor activities)

    田中 浩明, 天野 良亮, 野田 英児, 久保 尚士, 六車 一哉, 高島 勉, 八代 正和, 山田 靖哉, 小野田 尚佳, 澤田 鉄二, 仲田 文造, 大平 雅一, 平川 弘聖

    日本癌学会総会記事   68回   290 - 290   2009.08( ISSN:0546-0476

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  • トリプルネガティブ乳癌におけるE-cadherin発現

    柏木 伸一郎, 八代 正和, 高島 勉, 埜村 真也, 野田 諭, 川尻 成美, 小野田 尚佳, 仲田 文造, 石川 哲郎, 平川 弘聖

    日本乳癌学会総会プログラム抄録集   17回   317 - 317   2009.06

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  • A novel transforming growth factor \#946; receptor kinase inhibitor, A-77, prevents the peritoneal dissemination of scirrhous gastric carcinoma

    Masakazu Yashiro, Hidemi Kawajiri, Osamu Shinto, Satoru Noda, Takafumi Nshii, Yuhiko Fuyuhiro, Shinichiro Kashiwagi, Manabu Node, Kohei Miyazono, Masaichi Ohira, Kosei Hirakawa

    CANCER RESEARCH   69   2009.05( ISSN:0008-5472 ( eISSN:1538-7445

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  • Hypoxic condition promotes the adhesion ability of gastric cancer cells to peritoneum

    Satoru Noda, Masakazu Yashiro, Takafumi Nshii, Yuhiko Fuyuhiro, Yukihiro Kato, Shinichiro Kashiwagi, Masaichi Ohira, Manabu Node, Kosei Hirakawa

    CANCER RESEARCH   69   2009.05( ISSN:0008-5472 ( eISSN:1538-7445

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  • 【消化器癌〜診断・治療のすべて】 緩和ケア 癌の告知

    野田 英児, 前田 清, 井上 透, 高島 勉, 小野田 尚佳, 山田 靖哉, 八代 正和, 澤田 鉄二, 仲田 文造, 大平 雅一, 石川 哲郎, 平川 弘聖

    消化器外科   32 ( 5 )   973 - 975   2009.04( ISSN:0387-2645

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  • 腹腔鏡下胃切除術時の肝挙上法の工夫

    豊川 貴弘, 六車 一哉, 澤田 鉄二, 久保 尚士, 田中 浩明, 八代 正和, 山田 靖哉, 山下 好人, 前田 清, 小野田 尚佳, 仲田 文造, 西口 幸雄, 大平 雅一, 石川 哲郎, 平川 弘聖

    日本胃癌学会総会記事   81回   259 - 259   2009.03

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  • 難治性乳癌(トリプルネガティブ)におけるE-cadherin発現

    柏木 伸一郎, 八代 正和, 高島 勉, 埜村 真也, 野田 諭, 川尻 成美, 小野田 尚佳, 仲田 文造, 石川 哲郎, 平川 弘聖

    日本外科学会雑誌   110 ( 臨増2 )   658 - 658   2009.02( ISSN:0301-4894

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  • PSKとTGFbeta阻害剤の併用による癌宿主の免疫応答増強効果

    田中 浩明, 八代 正和, 野田 英児, 天野 良亮, 久保 尚士, 六車 一哉, 井上 透, 山田 靖哉, 前田 清, 小野田 尚佳, 澤田 鉄二, 仲田 文造, 大平 雅一, 石川 哲郎, 平川 弘聖

    日本外科学会雑誌   110 ( 臨増2 )   739 - 739   2009.02( ISSN:0301-4894

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  • 膵癌外科治療における補助化学療法としてのGEM,TS-1の役割

    天野 良亮, 山田 靖哉, 土井 洋輔, 西居 孝文, 河本 真大, 野田 英児, 久保 尚士, 田中 浩明, 六車 一哉, 高島 勉, 井上 透, 山下 好人, 八代 正和, 小野田 尚佳, 前田 清, 澤田 鉄二, 西口 幸雄, 仲田 文造, 大平 雅一, 石川 哲郎, 平川 弘聖

    日本外科学会雑誌   110 ( 臨増2 )   509 - 509   2009.02( ISSN:0301-4894

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  • 臨床病理カンファレンス 残胃癌

    八代 正和, 豊川 貴弘, 鰐渕 英機, 小野田 尚佳, 羽室 雅夫, 渡辺 俊雄, 斯波 将次, 六車 一哉, 富永 和作, 山下 好人, 澤田 鉄二, 大平 雅一, 平川 弘聖, 上田 真喜子

    綜合臨床   58 ( 2 )   370 - 377   2009.02( ISSN:0371-1900

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  • Effect of TGFβ-receptor inhibitor on the peritoneal metastasis of gastric carcinoma Reviewed

    Japanese journal of cancer clinics   55 ( 1 )   81 - 90   2009( ISSN:0021-4949

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    Other URL: http://search.jamas.or.jp/link/ui/2009153894

  • 大腸癌術前機械的腸管処置の術後合併症に及ぼす影響

    野田 英児, 前田 清, 井上 透, 八代 正和, 山田 靖哉, 山下 好人, 高島 勉, 小野田 尚佳, 六車 一哉, 澤田 鉄二, 仲田 文造, 西口 幸雄, 大平 雅一, 石川 哲郎, 平川 弘聖

    日本臨床外科学会雑誌   69 ( 増刊 )   340 - 340   2008.10( ISSN:1345-2843

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  • 潰瘍性大腸炎に併発する大腸癌とVitamin D Receptor発現との関連性

    田中 浩明, 前田 清, 和田 光二, 野田 英児, 天野 良亮, 久保 尚士, 六車 一哉, 井上 透, 高島 勉, 八代 正和, 山田 靖哉, 小野田 尚佳, 澤田 鉄二, 仲田 文造, 大平 雅一, 石川 哲郎, 平川 弘聖

    日本癌治療学会誌   43 ( 2 )   851 - 851   2008.10( ISSN:0021-4671

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  • 胃癌におけるペリオスチン 癌微小環境において間質線維芽細胞がペリオスチンを介して癌細胞の増殖を促進する(Periostin in gastric cancer: Stromal fibroblasts support growth of cancer cell via periostin in cancer microenvironment)

    菊地 良直, 岩田 要, 西山 尚志, 鹿島 健司, 狩野 光伸, 森下 保幸, 喜井 勲, 八代 正和, 新谷 裕加子, 平川 弘聖, 宮園 浩平, 工藤 明, 深山 正久

    日本癌学会総会記事   67回   417 - 417   2008.09( ISSN:0546-0476

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  • 膵全体を占める非機能性膵内分泌腫瘍の1例

    渋谷 雅常, 天野 良亮, 高島 勉, 八代 正和, 山田 靖哉, 小野田 尚佳, 澤田 鉄二, 仲田 文造, 大平 雅一, 石川 哲郎, 平川 弘聖

    日本内分泌外科学会総会プログラム・抄録集   20回   53 - 53   2008.06

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  • 腹壁 (手術局所解剖アトラス) -- (腹壁・鼠径部領域) Reviewed

    天野 良亮, 山田 靖哉, 八代 正和

    手術   62 ( 6 )   705 - 709   2008.05( ISSN:0037-4423

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    Other URL: http://search.jamas.or.jp/link/ui/2008228941

  • スキルス胃癌への新しいアプローチ スキルス胃癌の病態に基づいた分子標的治療薬の検討

    八代 正和, 川尻 成美, 神藤 理, 中村 和憲, 豊川 貴弘, 山下 好人, 山田 靖哉, 小野田 尚佳, 前田 清, 澤田 鉄二, 大平 雅一, 宮園 浩平, 野出 学, 梶本 哲也, 平川 弘聖

    日本外科学会雑誌   109 ( 臨増2 )   129 - 129   2008.04( ISSN:0301-4894

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  • 分子標的治療薬TGFbetaレセプター阻害剤の癌免疫療法への応用

    田中 浩明, 八代 正和, 神藤 理, 野田 英児, 天野 良亮, 久保 尚士, 六車 一哉, 井上 透, 山田 靖哉, 前田 清, 小野田 尚佳, 仲田 文造, 澤田 鉄二, 大平 雅一, 石川 哲郎, 平川 弘聖

    日本外科学会雑誌   109 ( 臨増2 )   247 - 247   2008.04( ISSN:0301-4894

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  • スキルス胃癌の増殖・進展におけるTGF‐βの役割

    古室暁義, 岩田要, 八代正和, 森下保幸, JOHANSSON Erik, 松元芳子, 清野邦彦, 白井陽太郎, 鈴木洋, 平川弘聖, 狩野光伸, 宮園浩平

    日本病理学会会誌   97 ( 1 )   232   2008.03( ISSN:0300-9181

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    J-GLOBAL

  • Reply: Identification of isolated tumour cells by detection of CEA and CK mRNA in peritoneal lavage fluid of gastric cancer patients

    K. Katsuragi, M. Yashiro, K. Hirakawa

    BRITISH JOURNAL OF CANCER   98 ( 2 )   514 - 514   2008.01( ISSN:0007-0920

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    DOI: 10.1038/sj.bjc.6604190

  • 癌リンパ管新生からみた,スキルス胃癌のリンパ行性転移および腹膜播種の病態についての基礎的研究 Reviewed

    岩田要, 八代正和, 平川弘聖, 宮園浩平, 上西紀夫

    日本外科学会雑誌   109   2008( ISSN:0301-4894

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  • 術中異常高血圧を呈した無症候性後腹膜傍神経節腫の1例

    大北 仁裕, 天野 良亮, 森本 純也, 野田 英児, 山下 好人, 八代 正和, 山田 靖哉, 小野田 尚佳, 西口 幸雄, 澤田 鉄二, 大平 雅一, 石川 哲郎, 平川 弘聖

    日本臨床外科学会雑誌   68 ( 増刊 )   1198 - 1198   2007.11( ISSN:1345-2843

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  • いわゆるホームレス状態における胃癌症例の検討

    田中 浩明, 小野田 尚佳, 平田 啓一郎, 井上 透, 高島 勉, 八代 正和, 仲田 文造, 大平 雅一, 石川 哲郎, 平川 弘聖

    日本臨床外科学会雑誌   68 ( 増刊 )   460 - 460   2007.11( ISSN:1345-2843

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  • 胃小細胞癌の4例

    貝崎 亮二, 野田 諭, 松崎 太郎, 豊川 貴弘, 久保 尚士, 六車 一哉, 八代 正和, 山下 好人, 山田 靖哉, 小野田 尚佳, 澤田 鉄二, 西口 幸雄, 大平 雅一, 石川 哲郎, 平川 弘聖

    日本臨床外科学会雑誌   68 ( 増刊 )   726 - 726   2007.11( ISSN:1345-2843

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  • Suppression of tumor lymphangiogenesis and lymph node metastasis by conventional cyclooxygenase-2 (COX-2) inhibitor, Etodolac

    Caname Iwata, Mitsunobu R. Kano, Masakazu Yashiro, Kosei Hirakawa, Kohei Miyazono, Michio Kaminishi

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   22   A229 - A229   2007.10( ISSN:0815-9319

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  • 自動縫合器(リニアステイプラーを中心に) (特集 手術機器--利点と注意点) Reviewed

    藤原 一郎, 八代 正和, 山下 好人

    手術   61 ( 8 )   1079 - 1087   2007.07( ISSN:0037-4423

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    CiNii Article

    Other URL: http://search.jamas.or.jp/link/ui/2007335167

  • 胃癌切除症例におけるKGFおよびK-sam発現の免疫組織学的検討

    豊川 貴弘, 八代 正和, 井上 透, 山田 靖哉, 小野田 尚佳, 澤田 鉄二, 仲田 文造, 大平 雅一, 石川 哲郎, 平川 弘聖

    日本消化器外科学会雑誌   40 ( 7 )   1264 - 1264   2007.07( ISSN:0386-9768

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  • 胃癌細胞におけるERasシグナル伝達阻害剤の増殖抑制効果の検討

    松崎 太郎, 八代 正和, 安田 晃一, 貝崎 亮二, 山田 靖哉, 山下 好人, 前田 清, 小野田 尚佳, 西口 幸雄, 平川 弘聖

    日本消化器外科学会雑誌   40 ( 7 )   1157 - 1157   2007.07( ISSN:0386-9768

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  • 各種癌細胞株におけるERas遺伝子の発現とその制御

    安田 晃一, 八代 正和, 六車 一哉, 西原 承浩, 井上 透, 山下 好人, 山田 靖哉, 小野田 尚佳, 前田 清, 澤田 鉄二, 大平 雅一, 仲田 文造, 石川 哲郎, 西野 裕二, 平川 弘聖

    日本分子腫瘍マーカー研究会誌   22   30 - 31   2007.04

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  • Method of insertion and management for naso-gastric tube and ileus tube Reviewed

    96 ( 3 )   281 - 288   2007.03( ISSN:0433-2644

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    Other URL: http://search.jamas.or.jp/link/ui/2007150403

  • 胃癌組織におけるERasの発現

    貝崎 亮二, 八代 正和, 神藤 理, 田中 浩明, 六車 一哉, 井上 透, 山下 好人, 山田 靖哉, 小野田 尚佳, 前田 清, 澤田 鉄二, 仲田 文造, 西口 幸雄, 大平 雅一, 石川 哲郎, 加藤 保之, 平川 弘聖

    日本外科学会雑誌   108 ( 臨増2 )   261 - 261   2007.03( ISSN:0301-4894

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  • 胃癌腹膜播種におけるTGFβ-R阻害剤の有用性

    川尻 成美, 八代 正和, 竹村 哲, 中村 和憲, 天道 正成, 井上 透, 山田 靖哉, 山下 好人, 前田 清, 小野田 尚佳, 澤田 鉄二, 仲田 文造, 西口 幸雄, 大平 雅一, 石川 哲郎, 加藤 保之, 宮園 浩平, 野出 学, 梶本 哲也, 平川 弘聖

    日本外科学会雑誌   108 ( 臨増2 )   153 - 153   2007.03( ISSN:0301-4894

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  • スキルス胃癌の増殖・進展におけるTGF‐βの役割

    古室暁義, 岩田要, 岡雅子, 森下保幸, 八代正和, 平川弘聖, 狩野光伸, 宮園浩平

    日本病理学会会誌   96 ( 1 )   199   2007.02( ISSN:0300-9181

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    J-GLOBAL

  • Association between expression of chemokine receptor CXCR4 and lymph node metastasis in colorectal cancer

    Shinya Fukunaga, Kiyoshi Maeda, Eiji Noda, Tamahiro Nishihara, Touru Inoue, Nobuya Yamada, Yoshito Yamashita, Masakazu Yashiro, Tetuji Sawada, Masaichi Oohira, Kousei Hirakawa

    CLINICAL & EXPERIMENTAL METASTASIS   24 ( 4 )   279 - 279   2007( ISSN:0262-0898

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  • K-sam expression is associated with tumor progression and prognosis in gastric cancer

    Takahiro Toyokawa, Masakazu Yashiro, Kazuya Muguruma, Toru Inoue, Yoshito Yamashita, Tetsuji Sawada, Masaichi Ohira, Kosei Hirakawa

    CLINICAL & EXPERIMENTAL METASTASIS   24 ( 4 )   288 - 288   2007( ISSN:0262-0898

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  • Combination effect of transforming growth factor & beta-receptor inhibitor and S-1 on the lymph node metastasis for gastric cancer

    Hidemi Kawajiri, Masakazu Yashiro, Tendo Masashige, Nobuya Yamada, Tetsuji Sawada, Kosei Hirakawa

    CLINICAL & EXPERIMENTAL METASTASIS   24 ( 4 )   305 - 305   2007( ISSN:0262-0898

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  • Multiple gastric cancer Reviewed

    96   450 - 454   2007( ISSN:0433-2644

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    Other URL: http://search.jamas.or.jp/link/ui/2007196432

  • 当院における特発性血小板減少性紫斑病に対する腹腔鏡下脾臓摘出術の治療成績

    和田 光二, 山田 靖哉, 石川 哲郎, 天野 良亮, 山下 好人, 八代 正和, 小野田 尚佳, 前田 清, 澤田 鉄二, 大平 雅一, 西野 裕二, 平川 弘聖

    日本臨床外科学会雑誌   67 ( 増刊 )   1014 - 1014   2006.10( ISSN:1345-2843

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  • 胸部食道癌手術におけるクリニカルパスの取り組み

    松岡 順子, 山下 好人, 大平 雅一, 西原 承浩, 井上 透, 六車 一哉, 小野田 尚佳, 山田 靖哉, 八代 正和, 前田 清, 澤田 鉄二, 石川 哲郎, 平川 弘聖

    日本臨床外科学会雑誌   67 ( 増刊 )   846 - 846   2006.10( ISSN:1345-2843

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  • 高齢者に対するm-FOLFOX6の安全性の検討

    金 友英, 前田 清, 福永 真也, 野田 英児, 井上 透, 西原 承浩, 八代 正和, 山田 靖哉, 小野田 尚佳, 西口 幸雄, 大平 雅一, 石川 哲郎, 平川 弘聖

    日本癌治療学会誌   41 ( 2 )   404 - 404   2006.09( ISSN:0021-4671

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  • 進行、再発食道癌に対するDocetaxelを用いた化学療法の治療成績

    大平 雅一, 山下 好人, 中川 泰生, 六車 一哉, 井上 透, 西原 承浩, 山田 靖哉, 八代 正和, 前田 清, 小野田 尚佳, 澤田 鉄二, 西口 幸雄, 石川 哲郎, 加藤 保之, 平川 弘聖

    日本癌治療学会誌   41 ( 2 )   592 - 592   2006.09( ISSN:0021-4671

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  • Desmoglein 2発現低下はびまん浸潤型胃癌に関与する

    八代 正和, 西岡 伸明, 井上 透, 山下 好人, 山田 靖哉, 小野田 尚佳, 前田 清, 仲田 文造, 加藤 保之, 澤田 鉄二, 大平 雅一, 西口 幸雄, 平川 弘聖

    日本癌学会総会記事   65回   205 - 205   2006.09( ISSN:0546-0476

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  • 切除不能局所進行膵癌に対するgemcitabine+radiationの有効性の検討

    天野 良亮, 仲田 文造, 野田 英児, 山田 靖哉, 八代 正和, 小野田 尚佳, 前田 清, 澤田 鉄二, 大平 雅一, 石川 哲郎, 西野 裕二, 平川 弘聖

    日本癌治療学会誌   41 ( 2 )   684 - 684   2006.09( ISSN:0021-4671

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  • 当科における家族性胃癌の臨床病理学的検討

    豊川 貴弘, 八代 正和, 山下 好人, 山田 靖哉, 小野田 尚佳, 前田 清, 仲田 文造, 澤田 鉄二, 大平 雅一, 加藤 保之, 石川 哲郎, 平川 弘聖

    日本消化器病学会雑誌   103 ( 臨増大会 )   A802 - A802   2006.09( ISSN:0446-6586

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  • 大腸癌でのchemokine receptor CXCR4の発現とリンパ行性転移の検討

    福永 真也, 前田 清, 野田 英児, 西原 承浩, 井上 透, 山田 靖哉, 山下 好人, 八代 正和, 小野田 尚佳, 澤田 鉄二, 大平 雅一, 加藤 保之, 西口 幸雄, 平川 弘聖

    日本癌治療学会誌   41 ( 2 )   618 - 618   2006.09( ISSN:0021-4671

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  • 外来化学療法としてのm-FOLFOX6療法の副作用の検討

    野田 英児, 前田 清, 井上 透, 西原 承浩, 八代 正和, 山田 靖哉, 小野田 尚佳, 仲田 文造, 西口 幸雄, 大平 雅一, 石川 哲郎, 加藤 保之, 平川 弘聖

    日本大腸肛門病学会雑誌   59 ( 9 )   574 - 574   2006.09( ISSN:0047-1801

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  • 各種癌細胞株におけるERas遺伝子の発現とその制御

    安田 晃一, 八代 正和, 六車 一哉, 西原 承浩, 井上 透, 山下 好人, 山田 靖哉, 小野田 尚佳, 前田 清, 澤田 鉄二, 大平 雅一, 仲田 文造, 石川 哲郎, 西野 裕二, 平川 弘聖

    日本分子腫瘍マーカー研究会プログラム・講演抄録   26回   46 - 47   2006.09

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  • 胃癌とK-sam発現の免疫組織学的検討

    豊川 貴弘, 八代 正和, 井上 透, 山田 靖哉, 小野田 尚佳, 澤田 鉄二, 仲田 文造, 大平 雅一, 石川 哲郎, 平川 弘聖

    日本癌学会総会記事   65回   372 - 372   2006.09( ISSN:0546-0476

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  • 胃癌腹膜播種におけるTGFβ-R阻害剤A-77と抗癌剤S-1との併用効果

    川尻 成美, 八代 正和, 竹村 哲, 井上 透, 前田 清, 小野田 尚佳, 澤田 鉄二, 仲田 文造, 大平 雅一, 宮園 浩平, 野出 学, 梶本 哲也, 平川 弘聖

    日本癌学会総会記事   65回   487 - 487   2006.09( ISSN:0546-0476

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  • スキルス胃癌の悪性化におけるTGF‐βの役割

    古室暁義, 岩田要, 岡雅子, 森下保幸, 八代正和, 平川弘聖, 狩野光伸, 宮園浩平

    日本癌学会学術総会記事   65th   36   2006.08

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    J-GLOBAL

  • 胃癌におけるTGF‐β阻害剤と標的指向性DDSナノ粒子の併用効果

    岩田要, 狩野光伸, BAE Yoonsoo, 西山伸宏, 古室暁義, 森下保幸, 岡雅子, 八代正和, 平川弘聖, 片岡一則, 宮園浩平

    日本癌学会学術総会記事   65th   446   2006.08

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    J-GLOBAL

  • 食道表在癌におけるリンパ節転移とVEGF-Cの発現および簇出との関連についての検討

    中川 泰生, 大平 雅一, 山下 好人, 野田 英児, 山田 靖哉, 八代 正和, 前田 清, 澤田 鉄二, 小野田 尚佳, 平川 弘聖

    日本消化器外科学会雑誌   39 ( 7 )   1047 - 1047   2006.07( ISSN:0386-9768

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  • 血管新生阻害剤Ki23057を用いた大腸癌の分子標的治療

    櫻井 克宣, 山田 靖哉, 八代 正和, 小松 みどり, 小野田 尚佳, 西口 幸雄, 石川 哲郎, 加藤 保之, 三輪 篤史, 平川 弘聖

    日本消化器外科学会雑誌   39 ( 7 )   1077 - 1077   2006.07( ISSN:0386-9768

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  • 胃癌の進展とK-samII発現

    豊川 貴弘, 八代 正和, 井上 透, 山田 靖哉, 西口 幸雄, 加藤 保之, 小野田 尚佳, 仲田 文造, 石川 哲郎, 平川 弘聖

    日本消化器外科学会雑誌   39 ( 7 )   1060 - 1060   2006.07( ISSN:0386-9768

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  • がん治療と栄養管理の意義 胸部食道癌手術周術期における免疫強化栄養剤を用いた栄養管理について

    大平 雅一, 山下 好人, 中川 泰生, 六車 一哉, 井上 透, 西原 承浩, 山田 靖哉, 八代 正和, 前田 清, 小野田 尚佳, 澤田 鉄二, 西口 幸雄, 石川 哲郎, 加藤 保之, 平川 弘聖

    日本外科系連合学会誌   31 ( 3 )   507 - 507   2006.06( ISSN:0385-7883

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  • 胃癌のK-samII発現とKGFR阻害剤による分子標的治療の可能性

    豊川 貴弘, 八代 正和, 井上 透, 山田 靖哉, 小野田 尚佳, 澤田 鉄二, 仲田 文造, 大平 雅一, 石川 哲郎, 平川 弘聖

    日本外科系連合学会誌   31 ( 3 )   566 - 566   2006.06( ISSN:0385-7883

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  • 胸部食道癌術後の肺合併症におよぼす因子の検討

    大平 雅一, 山下 好人, 中川 泰生, 六車 一哉, 山田 靖哉, 八代 正和, 小野田 尚佳, 前田 清, 澤田 鉄二, 西口 幸雄, 平川 弘聖

    外科と代謝・栄養   40 ( 3 )   91 - 91   2006.06( ISSN:0389-5564

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  • 進行再発食道癌に対するDocetaxel,Nedaplatin,5-Fu併用化学療法の有用性について

    大平 雅一, 山下 好人, 中川 泰生, 六車 一哉, 井上 透, 西原 承浩, 山田 靖哉, 八代 正和, 前田 清, 小野田 尚佳, 澤田 鉄二, 西口 幸雄, 石川 哲郎, 加藤 保之, 平川 弘聖

    日本外科学会雑誌   107 ( 臨増2 )   433 - 433   2006.03( ISSN:0301-4894

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  • Ki23057を用いた大腸癌に対する血管新生阻害剤治療

    櫻井 克宣, 山田 靖哉, 八代 正和, 六車 一哉, 高島 勉, 井上 透, 西原 承浩, 山下 好人, 前田 清, 小野田 尚佳, 澤田 鉄二, 仲田 文造, 大平 雅一, 石川 哲郎, 西野 裕二, 三輪 隆史, 平川 弘聖

    日本外科学会雑誌   107 ( 臨増2 )   403 - 403   2006.03( ISSN:0301-4894

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  • 潰瘍性大腸炎に対するHand-assisted laparoscopic surgery 特に緊急手術例に対する適応拡大

    前田 清, 西原 承浩, 井上 透, 野田 英児, 福永 真也, 八代 正和, 山田 靖哉, 山下 好人, 小野田 尚佳, 西口 幸雄, 平川 弘聖

    日本外科学会雑誌   107 ( 臨増2 )   200 - 200   2006.03( ISSN:0301-4894

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  • 胃癌切除症例におけるK-sam発現の免疫組織学的検討

    豊川 貴弘, 八代 正和, 井上 透, 西原 承浩, 山下 好人, 山田 靖哉, 小野田 尚佳, 前田 清, 澤田 鉄二, 仲田 文造, 大平 雅一, 石川 哲郎, 西野 裕二, 平川 弘聖

    日本外科学会雑誌   107 ( 臨増2 )   361 - 361   2006.03( ISSN:0301-4894

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  • 直腸癌局所再発の臨床病理学的検討およびその予測因子としてのVEGF-C(vascular endothelial growth factor-C)発現

    野田 英児, 前田 清, 井上 透, 高島 勉, 六車 一哉, 西原 承浩, 山田 靖哉, 八代 正和, 山下 好人, 小野田 尚佳, 澤田 鉄二, 仲田 文造, 大平 雅一, 石川 哲郎, 西口 幸雄, 加藤 保之, 西野 裕二, 平川 弘聖

    日本外科学会雑誌   107 ( 臨増2 )   724 - 724   2006.03( ISSN:0301-4894

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  • 血中SPan-1値の変化はgemcitabineによる膵癌患者の予後延長を予測できるか

    天野 良亮, 仲田 文造, 天道 正成, 野田 英児, 山田 靖哉, 八代 正和, 前田 清, 小野田 尚佳, 澤田 鉄二, 大平 雅一, 石川 哲郎, 西野 裕二, 平川 弘聖

    日本分子腫瘍マーカー研究会誌   21   15 - 16   2006.01

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  • 直腸癌根治切除後局所再発の予測因子としての術前CEA(Carcinoembryonic antigen)値の有用性

    野田 英児, 前田 清, 天野 良亮, 六車 一哉, 井上 透, 西原 承浩, 山田 靖哉, 八代 正和, 山下 好人, 小野田 尚佳, 澤田 鉄二, 仲田 文造, 大平 雅一, 石川 哲郎, 西野 裕二, 平川 弘聖

    日本分子腫瘍マーカー研究会誌   21   17 - 18   2006.01

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  • 遺伝子メチル化からみた残胃初発癌の特異性

    小野田 尚佳, 巳野 綾, 綾 誠, 八代 正和, 山田 靖哉, 前田 清, 山下 好人, 西原 承浩, 澤田 鉄二, 大平 雅一, 石川 哲郎, 西口 幸雄, 加藤 保之

    日本臨床外科学会雑誌   66 ( 増刊 )   738 - 738   2005.10( ISSN:1345-2843

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  • 色素法は胃癌細胞が最初に転移する本来のセンチネルリンパ節を同定できているか?

    八代 正和, 小坂 博久, 葛城 圭, 澤田 鉄二, 山下 好人, 山田 靖哉, 前田 清, 小野田 尚佳, 仲田 文造, 大平 雅一, 加藤 保之, 西口 幸雄, 平川 弘聖

    日本臨床外科学会雑誌   66 ( 増刊 )   236 - 236   2005.10( ISSN:1345-2843

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  • 免疫抑制剤投与中に感染を機に発見された気管支嚢腫の一切除例

    伊藤 厳太郎, 山下 好人, 大平 雅一, 豊川 貴弘, 久保 尚士, 井上 透, 西原 承浩, 六車 一哉, 小野田 尚佳, 西口 幸雄, 石川 哲郎, 山田 靖哉, 八代 正和, 澤田 鉄二, 平川 弘聖

    日本臨床外科学会雑誌   66 ( 増刊 )   925 - 925   2005.10( ISSN:1345-2843

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  • 残胃初発癌における高頻度のp16遺伝子メチル化

    己野 綾, 小野田 尚佳, 藤原 一郎, 久保 尚志, 八代 正和, 山下 好人, 山田 靖哉, 西原 承造, 西口 幸雄, 加藤 保之, 澤田 鉄二, 大平 雅一, 石川 哲郎, 平川 弘聖

    日本臨床外科学会雑誌   66 ( 増刊 )   662 - 662   2005.10( ISSN:1345-2843

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  • 手術手技 炎症性腸疾患難治例に対するhand-assisted laparoscopic surgery Reviewed

    前田 清, 八代 正和, 西原 承浩

    手術   59 ( 11 )   1721 - 1725   2005.10( ISSN:0037-4423

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    Other URL: http://search.jamas.or.jp/link/ui/2006051438

  • 咽喉食摘後の再建胃管壊死および皮膚瘻に対してDUMONステントが有効であった一例

    松岡 順子, 山下 好人, 大平 雅一, 久保 尚士, 井上 透, 六車 一哉, 西原 承浩, 小野田 尚佳, 西口 幸雄, 八代 正和, 山田 靖哉, 前田 清, 澤田 鉄二, 加藤 保之, 平川 弘聖

    日本臨床外科学会雑誌   66 ( 増刊 )   909 - 909   2005.10( ISSN:1345-2843

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  • 胸腔鏡下食道癌根治術における種々の工夫

    山下 好人, 大平 雅一, 久保 尚士, 井上 透, 西原 承浩, 六車 一哉, 小野田 尚佳, 西口 幸雄, 石川 哲郎, 山田 靖哉, 八代 正和, 前田 清, 澤田 鉄二, 加藤 保之, 平川 弘聖

    日本臨床外科学会雑誌   66 ( 増刊 )   378 - 378   2005.10( ISSN:1345-2843

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  • 非閉塞性腸管梗塞の一例

    金 友英, 前田 清, 野田 英児, 高垣 敬一, 井上 透, 西原 承浩, 八代 正和, 山田 靖哉, 小野田 尚佳, 仲田 文造, 西口 幸雄, 大平 雅一, 石川 哲郎, 加藤 保之, 平川 弘聖

    日本大腸肛門病学会雑誌   58 ( 9 )   592 - 592   2005.09( ISSN:0047-1801

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  • RT-PCRによる腹腔内遊離胃癌細胞検出の臨床的有用性と腹膜転移の分子標的予防

    八代 正和, 葛城 圭, 小坂 博久, 松岡 翼, 井上 透, 山田 靖哉, 山下 好人, 小野田 尚佳, 前田 清, 澤田 鉄二, 仲田 文造, 西口 幸雄, 大平 雅一, 加藤 保之, 平川 弘聖

    日本癌治療学会誌   40 ( 2 )   358 - 358   2005.09( ISSN:0021-4671

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  • K-sam IIリン酸化阻害剤による4型胃癌の転移抑制

    中村 和憲, 八代 正和, 天道 正成, 井上 透, 山下 好人, 山田 靖哉, 西原 承浩, 高島 勉, 前田 清, 小野田 尚佳, 澤田 鉄二, 仲田 文造, 大平 雅一, 西野 裕二, 石川 哲郎, 三輪 篤史, 平川 弘聖

    日本癌治療学会誌   40 ( 2 )   469 - 469   2005.09( ISSN:0021-4671

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  • K-ras変異は隆起型胃癌の増殖に関与している

    八代 正和, 西岡 伸明, 山下 好人, 山田 靖哉, 小野田 尚佳, 前田 清, 澤田 鉄二, 井上 透, 仲田 文造, 西口 幸雄, 加藤 保之, 大平 雅一, 平川 弘聖

    日本癌学会総会記事   64回   236 - 236   2005.09( ISSN:0546-0476

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  • HER2高発現膵癌に対するTrastuzumabによる抗体療法

    木村 健二郎, 澤田 鉄二, 井上 雅文, 小松 みどり, 六車 一哉, 西原 承浩, 山下 好人, 八代 正和, 山田 靖哉, 前田 清, 小野田 尚佳, 西口 幸雄, 大平 雅一, 加藤 保之, 平川 弘聖

    日本癌治療学会誌   40 ( 2 )   390 - 390   2005.09( ISSN:0021-4671

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  • Fibroblast growth factor receptor2(FGFR2)阻害剤Ki23057による胆道癌の分子標的治療

    天野 良亮, 山田 靖哉, 八代 正和, 日月 亜紀子, 山下 好人, 前田 清, 小野田 尚佳, 澤田 鉄二, 仲田 文造, 大平 雅一, 石川 哲郎, 三輪 篤史, 平川 弘聖

    日本癌学会総会記事   64回   38 - 38   2005.09( ISSN:0546-0476

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  • 血中SPan-1値の変化はgemcitabineによる膵癌患者の予後延長を予測できるか

    天野 良亮, 仲田 文造, 天道 正成, 野田 英児, 山田 靖哉, 八代 正和, 前田 清, 小野田 尚佳, 澤田 鉄二, 大平 雅一, 石川 哲郎, 西野 裕二, 平川 弘聖

    日本分子腫瘍マーカー研究会プログラム・講演抄録   25回   28 - 29   2005.09

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  • Trastuzumab,Gemcitabine併用療法による膵癌に対する免疫化学療法

    木村 健二郎, 澤田 鉄二, 井上 雅文, 小松 みどり, 六車 一哉, 西原 承浩, 山下 好人, 山田 靖哉, 八代 正和, 小野田 尚佳, 前田 清, 大平 雅一, 平川 弘聖

    日本癌学会総会記事   64回   54 - 54   2005.09( ISSN:0546-0476

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  • 残胃癌組織におけるp16遺伝子メチル化

    己野 綾, 小野田 尚佳, 藤原 一郎, 久保 尚志, 八代 正和, 山下 好人, 山田 靖哉, 澤田 鉄二, 大平 雅一, 石川 哲郎, 平川 弘聖

    日本癌学会総会記事   64回   136 - 136   2005.09( ISSN:0546-0476

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  • 残胃初発癌における高頻度のp16遺伝子メチル化

    己野 綾, 小野田 尚佳, 藤原 一郎, 久保 尚志, 綾 誠, 八代 正和, 西原 承造, 山下 好人, 山田 靖哉, 西口 幸雄, 加藤 保之, 前田 清, 澤田 鉄二, 大平 雅一, 仲田 文造, 石川 哲郎, 平川 弘聖

    日本癌治療学会誌   40 ( 2 )   467 - 467   2005.09( ISSN:0021-4671

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  • 大腸癌肝転移に対する5-FU肝動注+CPT-11静注併用療法の検討

    山田 靖哉, 櫻井 克宣, 八代 正和, 山下 好人, 前田 清, 小野田 尚佳, 澤田 鉄二, 仲田 文造, 西口 幸雄, 大平 雅一, 石川 哲郎, 加藤 保之, 西野 裕二, 平川 弘聖

    日本癌治療学会誌   40 ( 2 )   411 - 411   2005.09( ISSN:0021-4671

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  • VEGFR阻害剤Ki23057による大腸癌の分子標的治療

    櫻井 克宣, 山田 靖哉, 八代 正和, 西原 承浩, 山下 好人, 前田 清, 小野田 尚佳, 澤田 鉄二, 仲田 文造, 大平 雅一, 石川 哲郎, 三輪 篤史, 平川 弘聖

    日本癌学会総会記事   64回   41 - 42   2005.09( ISSN:0546-0476

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  • 潰瘍性大腸炎緊急手術例に対する腹腔鏡補助下小開腹手術の成績

    井上 透, 前田 清, 八代 正和, 西原 承浩, 野田 英児, 山田 靖哉, 仲田 文造, 小野田 尚佳, 西口 幸雄, 大平 雅一, 石川 哲郎, 加藤 保之, 平川 弘聖

    日本大腸肛門病学会雑誌   58 ( 9 )   685 - 685   2005.09( ISSN:0047-1801

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  • 直腸癌治癒切除後の局所再発危険因子についての検討

    野田 英児, 前田 清, 井上 透, 西原 承浩, 八代 正和, 山田 靖哉, 小野田 尚佳, 仲田 文造, 西口 幸雄, 大平 雄一, 石川 哲郎, 加藤 保之, 平川 弘聖

    日本大腸肛門病学会雑誌   58 ( 9 )   649 - 649   2005.09( ISSN:0047-1801

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  • 直腸癌根治切除後局所再発の予測因子としての術前CEA(Carcinoembryonic antigen)値の有用性

    野田 英児, 前田 清, 天野 良亮, 六車 一哉, 井上 透, 西原 承浩, 山田 靖哉, 八代 正和, 山下 好人, 小野田 尚佳, 澤田 鉄二, 仲田 文造, 大平 雅一, 石川 哲郎, 西野 裕二, 平川 弘聖

    日本分子腫瘍マーカー研究会プログラム・講演抄録   25回   30 - 31   2005.09

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  • 遺伝子メチル化からみた残胃癌の特異性

    小野田 尚佳, 巳野 綾, 藤原 一郎, 久保 尚士, 綾 誠, 八代 正和, 山田 靖哉, 大平 雅一, 石川 哲郎, 平川 弘聖

    日本消化器外科学会雑誌   38 ( 7 )   1083 - 1083   2005.07( ISSN:0386-9768

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  • DNAマイクロアレイによるスキルス胃癌の遺伝子発現解析とK-samII阻害剤による分子標的治療

    八代 正和, 中村 和憲, 井上 透, 山田 靖哉, 小野田 尚佳, 前田 清, 澤田 鉄二, 大平 雅一, 三輪 篤史, 平川 弘聖

    日本消化器外科学会雑誌   38 ( 7 )   1083 - 1083   2005.07( ISSN:0386-9768

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  • 残胃癌におけるp16遺伝子メチル化についての検討

    己野 綾, 小野田 尚佳, 藤原 一郎, 久保 尚志, 綾 誠, 八代 正和, 山田 靖哉, 大平 雅一, 石川 哲郎, 平川 弘聖

    日本消化器外科学会雑誌   38 ( 7 )   1083 - 1083   2005.07( ISSN:0386-9768

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  • 消化器外科におけるクリニカルパスを導入した術後感染症に対する周術期管理について

    西原 承浩, 前田 清, 八代 正和, 山下 好人, 山田 靖哉, 小野田 尚佳, 澤田 鉄二, 大平 雅一, 石川 哲郎, 平川 弘聖

    日本消化器外科学会雑誌   38 ( 7 )   1090 - 1090   2005.07( ISSN:0386-9768

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  • 食道癌に対するPan-erbB tyrosine kinase inhibitor CI1033を用いた分子標的治療

    阿古 英次, 山下 好人, 大平 雅一, 山崎 政直, 井上 透, 西原 承浩, 八代 正和, 山田 靖哉, 小野田 尚佳, 前田 清, 澤田 鉄二, 西口 幸雄, 石川 哲郎, 加藤 保之, 平川 弘聖

    日本外科学会雑誌   106 ( 臨増 )   442 - 442   2005.04( ISSN:0301-4894

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  • ICAM-1遺伝子治療の大腸癌肝転移における可能性

    日月 亜紀子, 山田 靖哉, 坂手 洋二, 山下 好人, 八代 正和, 前田 清, 小野田 尚佳, 西口 幸雄, 大平 雅一, 石川 哲郎, 加藤 保之, 西野 裕二, 平川 弘聖

    日本外科学会雑誌   106 ( 臨増 )   416 - 416   2005.04( ISSN:0301-4894

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  • スキルス胃癌細胞の増殖進展における微小環境とkeratinocyte growth factorの関与

    八代 正和, 中澤 一憲, 松岡 翼, 井上 透, 天道 正成, 安田 晃一, 仲田 文造, 山田 靖哉, 前田 清, 小野田 尚佳, 澤田 鉄二, 西口 幸雄, 大平 雅一, 石川 哲郎, 加藤 保之, 平川 弘聖

    日本外科学会雑誌   106 ( 臨増 )   256 - 256   2005.04( ISSN:0301-4894

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  • 残胃癌におけるp16遺伝子メチル化についての検討

    己野 綾, 小野田 尚佳, 藤原 一郎, 久保 尚士, 綾 誠, 八代 正和, 西原 承造, 山下 好人, 山田 靖哉, 西口 幸雄, 加藤 保之, 前田 清, 澤田 鉄二, 大平 雅一, 仲田 文造, 石川 哲郎, 平川 弘聖

    日本外科学会雑誌   106 ( 臨増 )   248 - 248   2005.04( ISSN:0301-4894

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  • チロシンキナーゼ型KGF-receptorの阻害による4型胃癌の分子標的治療

    中村 和憲, 八代 正和, 天道 正成, 山田 靖哉, 澤田 鉄二, 小野田 尚佳, 大平 雅一, 前田 清, 仲田 文造, 三輪 篤史, 平川 弘聖

    日本外科学会雑誌   106 ( 臨増 )   509 - 509   2005.04( ISSN:0301-4894

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  • Usefulness of a Metallic Stent Placement for Obstructive Colorectal Cancer Reviewed

    MAEDA Kiyoshi, INOUE Toru, NISHIHARA Tamahiro, YASHIRO Masakazu, NODA Eiji, NISHIGUCHI Yukio, HIRAKAWA Kosei

    25 ( 3 )   513 - 515   2005.03( ISSN:1340-2242

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    CiNii Article

  • TGF-β1 produced by gastric cncer cells affects mesothelial cell morphology in peritoneal dissemination((Multiple Authorship))

    Int. J. Oncology   12   847 - 851   1998

  • Establishment of lymph node metastatic model for human gastric cancer in nude mice and analysis of factors associated with metastasis((Multiple Authorship))

    Clin. Exp. Metastasis   16   389 - 398   1998

  • Adhesion polypeptides are useful for the prevention of peritoneal dissemination of gastric cancer((Multiple Authorship))

    Clin. Exp. Metastasis   16   381 - 388   1998

  • Establishment of a cisplatin-resistant gastric carcinoma cell line OCUM-2M/DDP((Multiple Authorship))

    Cancer Chemotherapy and Pharmacology   40   94 - 97   1997

  • Transforming growth factor-β and hepatocyte growth factor produced by gastric fibroblasts stimulate the invasiveness of scirrhous gaastric cancer cells((Multiple Authorship))

    Jpn J Cancer Res   88   152 - 159   1997

  • 腹膜転移の機序とその治療の可能性(共著)

    -

    癌と化学療法   23/10   1996

  • Differential responses of scirrhous and well-differentiated gastric cancer cells to orthotopic fibroblasts((Multiple Authorship))

    British. J. Cancer   74   1096 - 1103   1996

  • Fibrosis in the peritoneum induced by scirrhous gastric cancer cells may act as "soil" for peritoneal dissemination((Multiple Authorship))

    Cancer   77   1668 - 1675   1996

  • Hepatocyte growth factor(HGF)produced by peritoneal fibroblasts may affect mesothelial cell morphology and promote peritoneal dissemination((Multiple Authorship))

    International J Cancer   67   289 - 293   1996

  • Peritoneal metastatic model for human scirrhous gastric carcinoma in nude mice((Multiple Authorship))

    Clin. Exp. Metastasis   14   43 - 54   1996

  • Role of alpha 2 beta 1-and alpha 3 beta 1-integrin in the peritoneal implantation of scirrhous gastric carcinoma((Multiple Authorship))

    British Journal of Cancer   74   1406 - 1412   1996

  • CD44H plays an important role in peritoneal dissemination of scirrhous gastric cancer cells((Multiple Authorship))

    Japanese Journal of Cancer Research   87   1235 - 1244   1996

  • 胃癌腹膜播種性転移機序に関する考察(ヌードマウス転移モデルの作成とその病態を中心として)(共著)

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    消化器外科   19/10   1996

  • 胃癌腹膜播種性転移機序に関与する因子(共著)

    -

    消化器科   23 ( 6 )   597 - 604   1996

  • 膜播種性転移胃癌(その特性からみた治療への考慮)(共著)

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    外科治療   75 ( 3 )   698 - 702   1996

  • 胃癌腹膜播種の病態と新しい治療の可能性(共著)

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    消化器外科   18   1899 - 1908   1995

  • Establishment of two new scirrhous gastric cancer cell lines : analysis of factors associated with disseminated metastasis((Multiple Authorship))

    Br. J. Cancer   72   1200 - 1210   1995

  • 腹膜播種性転移における腹膜線維化の意義(共著)

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    消化器癌の発生と進展   7   281 - 282   1995

  • 腹膜播種成立過程における4型スキルス胃癌細胞の腹膜中皮細胞への影響(共著)

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    消化器癌の発生と進展   7   449 - 451   1995

  • スキルス胃癌原発巣由来細胞株OCUM-2Mの樹立と増殖因子の関与(共著)

    -

    日本消化器病学会雑誌   92   199 - 205   1995

  • スキルス胃癌由来の腹膜播種における着床機転に関する検討(共著)

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    消化器癌の発生と進展   6   405 - 408   1994

  • Role of orthotopic fibroblasts in development of scirrhous gastric carcinoma((Multiple Authorship))

    Jpn. J. Cancer Res   84   883 - 886   1994

  • スキルス胃癌由来の高播種性転移モデルの作成(共著)

    -

    日本外科学会雑誌   95   288   1994

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Industrial Property Rights

  • スキルス性胃癌の治療剤、及び胃癌の予後の予測方法

    平川 弘聖, 八代 正和, 笠島 裕明, 日野 雅之, 中前 博久, 中根 孝彦

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    Application no:特願2021-073627 

    Announcement no:特開2021-113824 

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  • 癌患者の腹膜播種転移の可能性を判定するための検査方法、及び検査キット

    八代正和,、大平雅一、三木友一朗

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    Application no:特願2016-182130 

  • 癌患者の腹膜播種転移の可能性を判定するための検査方法、及び、検査キット

    八代 正和, 大平 雅一, 三木 友一朗

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    property_type:Patent 

    Application no:特願2016-182130 

    Announcement no:特開2018-044933 

    J-GLOBAL

  • 癌患者の腹膜播種転移の可能性を判定するための検査方法、及び、検査キット

    八代 正和, 大平 雅一, 三木 友一朗

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    property_type:Patent 

    Application no:特願2016-182130 

    Announcement no:特開2018-044933 

    Patent/Registration no:特許第6799239号 

    J-GLOBAL

  • スキルス性胃癌の治療剤、及び胃癌の予後の予測方法

    平川 弘聖, 八代 正和, 笠島 裕明, 日野 雅之, 中前 博久, 中根 孝彦

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    property_type:Patent 

    Application no:特願2016-098055 

    Announcement no:特開2017-206447 

    J-GLOBAL

  • スキルス性胃癌の治療剤、及び胃癌の予後の予測方法

    平川 弘聖, 八代 正和, 笠島 裕明, 日野 雅之, 中前 博久, 中根 孝彦

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    property_type:Patent 

    Application no:特願2016-098055 

    Announcement no:特開2017-206447 

    Patent/Registration no:特許第6932365号 

    J-GLOBAL

  • スキルス性胃癌の治療剤、及び胃癌の予後の予測方法

    平川 弘聖, 八代 正和, 笠島 裕明, 日野 雅之, 中前 博久, 中根 孝彦

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    property_type:Patent 

    Application no:特願2016-098055 

    Announcement no:特開2021-113824 

    Patent/Registration no:特許第7203447号 

    J-GLOBAL

  • 癌の罹患の有無の判別方法並びに癌の治療及び/又は予防のための医薬組成物

    間野 博行, 上野 敏秀, 崔 永林, 八代 正和

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    property_type:Patent 

    Application no:特願2015-168169 

    Announcement no:特開2017-042111 

    J-GLOBAL

  • プロスタグランジンD2合成酵素を利用した消化器癌治療剤

    平川 弘聖, 八代 正和, 福岡 達成

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    property_type:Patent 

    Application no:特願2013-268465 

    Announcement no:特開2015-124163 

    Patent/Registration no:特許第6278391号 

    J-GLOBAL

  • プロスタグランジンD2合成酵素を利用した消化器癌治療剤

    平川 弘聖, 八代 正和, 福岡 達成

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    property_type:Patent 

    Application no:特願2013-268465 

    Announcement no:特開2015-124163 

    J-GLOBAL

  • プライマー、腫瘍マーカー、および癌の検出方法

    八代正和, 平川弘聖, 澤田鉄二

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    property_type:Patent 

    Application no:JP2007059986 

    Announcement no:WO2007-132864 

    J-GLOBAL

  • TGF−βシグナル阻害剤と抗腫瘍剤の組み合せ使用

    片岡 一則, 宮園 浩平, 狩野 光伸, バエ・ヨウンスー, 西山 伸宏, 平川 弘聖, 八代 正和, 野出 學

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    property_type:Patent 

    Application no:JP2006317593 

    Announcement no:WO2007-088651 

    J-GLOBAL

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Outline of collaborative research (seeds)

  • 癌の増殖進展機序の解析

    2010-2012

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    Request for collaborative research:Universities etc. Research institutes

    Type of research exchange:Joint research

    Application fields / methods etc:培養細胞

    消化器癌の増殖・転移機序の解明

Grant-in-Aid for Scientific Research

  • Development of companion tools for CXCL1 signaling target therapy against CAF in scirrhous gastric carcinoma

    Grant-in-Aid for Scientific Research(B)  2028

  • Development of companion tools for CXCL1 signaling target therapy against CAF in scirrhous gastric carcinoma

    Grant-in-Aid for Scientific Research(B)  2027

  • スキルス胃癌微小環境におけるCAF教育-進展機構の解明

    Grant-in-Aid for Scientific Research(C)  2026

  • Development of companion tools for CXCL1 signaling target therapy against CAF in scirrhous gastric carcinoma

    Grant-in-Aid for Scientific Research(B)  2026

  • スキルス胃癌微小環境におけるCAF教育-進展機構の解明

    Grant-in-Aid for Scientific Research(C)  2025

  • 癌関連線維芽細胞の産生するCD9陽性エクソソームに含まれる悪性黒色腫抑制因子の同定

    Grant-in-Aid for Scientific Research(C)  2025

  • Elucidation of Prostaglandin D Receptor-mediated Carcinogenesis Mechanism of Colitic Cancer

    Grant-in-Aid for Scientific Research(C)  2025

  • Development of companion tools for CXCL1 signaling target therapy against CAF in scirrhous gastric carcinoma

    Grant-in-Aid for Scientific Research(B)  2025

  • スキルス胃癌微小環境におけるCAF教育-進展機構の解明

    Grant-in-Aid for Scientific Research(C)  2024

  • 癌関連線維芽細胞の産生するCD9陽性エクソソームに含まれる悪性黒色腫抑制因子の同定

    Grant-in-Aid for Scientific Research(C)  2024

  • Elucidation of Prostaglandin D Receptor-mediated Carcinogenesis Mechanism of Colitic Cancer

    Grant-in-Aid for Scientific Research(C)  2024

  • 難治口腔がんに対するウイルス療法の開発―免疫チェックポイント阻害剤併用療法ー

    Grant-in-Aid for Scientific Research(C)  2024

  • 深海放線菌が産生する新規の胃癌抑制物質の同定

    Grant-in-Aid for Scientific Research(C)  2024

  • Development of anti-scirrhous stomach cancer produced by the deep-sea actinomyces

    Grant-in-Aid for Scientific Research(B)  2024

  • Development of companion tools for CXCL1 signaling target therapy against CAF in scirrhous gastric carcinoma

    Grant-in-Aid for Scientific Research(B)  2024

  • ヒト化CXCL1抗体の癌関連線維芽細胞(CAF)抑制作用によるスキルス胃癌治療

    基盤研究(B)  2021.04

  • スキルス胃癌組織構築機序の解明と治療開発:骨髄細胞と癌幹細胞による間質形成の解析

    スキルス胃癌組織構築機序の解明と治療開発:骨髄細胞と癌幹細胞による間質形成の解析  2018.04

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Outline of education staff

  • colorectal tumor
    cancer genome

Charge of on-campus class subject

  • Lecture for Genome Surgical Oncology

    2024     Graduate school

  • Practice in Molecular Traget Therapy for Cancer

    2024     Graduate school

  • Molecular Therapeutics for Cancer

    2024     Graduate school

  • Molecular Oncology and Therapeutics

    2024     Graduate school

  • Basic Course of Geriatrics

    2024     Graduate school

  • Geriatrics

    2024     Graduate school

  • ゲノム医科学

    2020     Undergraduate

  • 腫瘍外科学

    1998     Undergraduate

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Charge of off-campus class subject

  • 癌細胞の分子生物学

  • 消化器外科

Social Activities ⇒ Link to the list of Social Activities

  • 国立がん研究センター東病院TRプロジェクトカンファレンス

    Role(s): Guest

    Type: University open house, Cooperation business with The administrative, educational institutions, etc.

    国立がん研究センター東病院  2013.09

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    国立がん研究センターの医療関係者に胃癌分子標的阻害剤の非臨床試験の結果を解説した

Foreigner acceptance

  • 2012

    foreigners accepted :1

    International Students :1

  • 1014

    foreigners accepted :1

    International Students :1

Other

  • Job Career

    1998.07 - Now

  • Job Career

    1988.06 - 1990.05