Updated on 2024/04/25
Graduate School of Medicine Department of Basic Medical Science
Lecturer 2022.04 - Now
School of Medicine Department of Medical Science
Lecturer 2022.04 - Now
Ph. D. （ Osaka University ）
Life Science / Medical biochemistry / 分子細胞生物学, タンパク質科学
Life Science / Pathological biochemistry
Life Science / Molecular biology
サイトカイン
細胞増殖・細胞死・細胞老化
オミックス解析
Signal transduction of cytokine receptors
cytokine, signal transduction Individual
1991.04 - Now
The Molecular Biology Society of Japan
Domestic
日本癌学会
日本免疫学会
The Japanese Biochemical Society
Osaka University Doctor's Course
RBM10 regulates centriole duplication in HepG2 cells by ectopically assembling PLK4-STIL complexes in the nucleus Reviewed
Kunimoto Hiroyuki, Inoue Akira, Kojima Hirotada, Yang Junhao, Zhao Hong, Tsuruta Daisuke, Nakajima Koichi
GENES TO CELLS 25 ( 2 ) 100 - 110 2020.02（ ISSN:1356-9597 ）
PITX1 protein interacts with ZCCHC10 to regulate hTERT mRNA transcription Reviewed
Ohira Takahito, Kojima Hirotada, Kuroda Yuko, Aoki Sayaka, Inaoka Daigo, Osaki Mitsuhiko, Wanibuchi Hideki, Okada Futoshi, Oshimura Mitsuo, Kugoh Hiroyuki
PLOS ONE 14 ( 8 ) e0217605 2019.08（ ISSN:1932-6203 ）
Deacetylation of the mitotic checkpoint protein BubR1 at lysine 250 by SIRT2 and subsequent effects on BubR1 degradation during the prometaphase/anaphase transition Reviewed
Suematsu Tomohisa, Li Yanze, Kojima Hirotada, Nakajima Koichi, Oshimura Mitsuo, Inoue Toshiaki
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 453 ( 3 ) 588 - 594 2014.10（ ISSN:0006-291X ）
SIRT2 knockdown increases basal autophagy and prevents postslippage death by abnormally prolonging the mitotic arrest that is induced by microtubule inhibitors Reviewed
Inoue Toshiaki, Nakayama Yuji, Li Yanze, Matsumori Haruka, Takahashi Haruka, Kojima Hirotada, Wanibuchi Hideki, Katoh Motonobu, Oshimura Mitsuo
FEBS JOURNAL 281 ( 11 ) 2623 - 2637 2014.06（ ISSN:1742-464X ）
IL-6-STAT3 signaling and premature senescence. Reviewed
Kojima H, Inoue T, Kunimoto H, Nakajima K
JAK-STAT 2 ( 4 ) e25763 2013.10（ ISSN:2162-3988 ）
S1-1/RBM10: Multiplicity and cooperativity of nuclear localisation domains Reviewed
Xiao Sheng-Jun, Wang Ling-Yu, Kimura Masatsugu, Kojima Hirotada, Kunimoto Hiroyuki, Nishiumi Fumiko, Yamamoto Naoki, Nishio Koji, Fujimoto Shunsuke, Kato Takayuki, Kitagawa Seiichi, Yamane Hideo, Nakajima Koichi, Inoue Akira
BIOLOGY OF THE CELL 105 ( 4 ) 162 - 174 2013.04（ ISSN:0248-4900 ）
The STAT3-IGFBP5 axis is critical for IL-6/gp130-induced premature senescence in human fibroblasts Reviewed
Kojima Hirotada, Kunimoto Hiroyuki, Inoue Toshiaki, Nakajima Koichi
CELL CYCLE 11 ( 4 ) 730 - 739 2012.02（ ISSN:1538-4101 ）
Phospho-Ser727 of STAT3 regulates STAT3 activity by enhancing dephosphorylation of phospho-Tyr705 largely through TC45 Reviewed
Wakahara Ryohei, Kunimoto Hiroyuki, Tanino Kanae, Kojima Hirotada, Inoue Akira, Shintaku Haruo, Nakajima Koichi
GENES TO CELLS 17 ( 2 ) 132 - 145 2012.02（ ISSN:1356-9597 ）
SIRT2 down-regulation in HeLa can induce p53 accumulation via p38 MAPK activation-dependent p300 decrease, eventually leading to apoptosis Reviewed
Li Yanze, Matsumori Haruka, Nakayama Yuji, Osaki Mitsuhiko, Kojima Hirotada, Kurimasa Akihiro, Ito Hisao, Mori Seiichi, Katoh Motonobu, Oshimura Mitsuo, Inoue Toshiaki
GENES TO CELLS 16 ( 1 ) 34 - 45 2011.01（ ISSN:1356-9597 ）
STAT3 regulates Nemo-like kinase by mediating its interaction with IL-6-stimulated TGF beta-activated kinase 1 for STAT3 Ser-727 phosphorylation Reviewed
Kojima H, Sasaki T, Ishitani T, Iemura S, Zhao H, Kaneko S, Kunimoto H, Natsume T, Matsumoto K, Nakajima K
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 102 ( 12 ) 4524 - 4529 2005.03（ ISSN:0027-8424 ）
STAT3 regulates Nemo-like kinase by mediating its interaction with IL-6-stimulated TGFβ-activated kinase 1 for STAT3 Ser727 phosphorylation.
Proc. Natl. Acad. Sci. USA. 102 ( 12 ) 4524 - 4529 2005
Region 752-761 of STAT3 is critical for SRC-1 recruitment and Ser727 phosphorylation.
Biochem. Biophys. Res. Commun. 325(2): 541-548 325 ( 2 ) 541 - 548 2004
Cytoplasmic c-Fos induced by the YXXQ-derived STAT3 signal requires the co-operative MEK/ERK signal for its nuclear translocation
Genes to Cells 9 233 - 242 2004
An essential role for NF-kappa B in IL-18-induced IFN-gamma expression in KG-1 cells
J. Immunol. 162 ( 9 ) 5063 - 5069 1999
Interleukin-18 induces interferon-gamma production through NF-kappaB and NFAT activation in murine T helper type 1 cells.
Cell Immunol 196 ( 1 ) 41 - 50 1999
Interleukin-18 activates the IRAK-TRAF6 pathway in mouse EL-4 cells
Biochem. Biophys. Res. Commun. 244 ( 1 ) 183 - 186 1998
Purification and characterization of the human interleukin-18 receptor
J. Biol. Chem 272 ( 41 ) 25737 - 25742 1997
IL-6-inducible complexes on an IL-6 response element of the junB promoter contain Stat3 and 36 kDa CRE-like site binding protein(s)
Oncogene 12 ( 3 ) 547 - 554 1996
A central role for Stat3 in IL-6-induced regulation of growth and differentiation in M1 leukemia cells
EMBO J. 5 ( 14 ) 3651 - 3658 1996
IL-6-STAT3 signaling and premature senescence Invited Reviewed
Hirotada Kojima, Toshiaki Inoue, Hiroyuki Kunimoto, Koichi Nakajima
JAK-STAT 2 ( 4 ) e25763 2013.07
IL-6-STAT3 signaling and premature senescence Reviewed
Hirotada Kojima, Toshiaki Inoue, Hiroyuki Kunimoto, Koichi Nakajima
JAK-STAT 2 ( 4 ) e25763 2013.07
【サイトカインと疾患 あらたな病態モデルから治療へ】 サイトカインシグナル伝達機構 JAK-STATの標準経路と非標準経路モデル Reviewed
中嶋 弘一, 小島 裕正
医歯薬出版(株) 医学のあゆみ 234 ( 5 ) 325 - 330 2010.07（ ISSN:0039-2359 ）
【サイトカインと疾患 あらたな病態モデルから治療へ】 サイトカインシグナル伝達機構 JAK-STATの標準経路と非標準経路モデル Reviewed
中嶋 弘一, 小島 裕正
医歯薬出版(株) 医学のあゆみ 234 ( 5 ) 325 - 330 2010.07（ ISSN:0039-2359 ）
Kojima Hirotada, Ayata Minoru
日本生化学会大会プログラム・講演要旨集 2021.11 (公社)日本生化学会
麻疹ウイルスOsaka-1・Osaka-2 SSPE株由来Vタンパク質によるインターフェロン情報伝達の調節(Regulation of interferon signaling by the V proteins from the Osaka-1 and Osaka-2 SSPE strains of measles virus) Domestic conference
Kojima Hirotada, Ayata Minoru
日本薬学会年会要旨集 2021.03 (公社)日本薬学会
サイトカイン機能を調節する分子を検索するためのシンプルな細胞ベースのアッセイ系の開発(Establishment of a simple cell-based assay system for identifying modulator of cytokine function) Domestic conference
Kojima Hirotada
日本生化学会大会プログラム・講演要旨集 2019.09 (公社)日本生化学会
RBM10の活動度を制御する自己調節機構 S1-1 NB-targeting Domestic conference
井上 晃, 國本 浩之, 王 凌宇, 肖 勝軍, 小島 裕正, 山本 隆博, 山本 直樹, 木村 政継, 徳永 和明, 谷 時雄, 中嶋 弘一, 井口 広義
生命科学系学会合同年次大会 2017.12 生命科学系学会合同年次大会運営事務局
Role of STBP-1 phosphorylation in regulating gene expression Domestic conference
Kojima Hirotada
生命科学系学会合同年次大会 2017.12 生命科学系学会合同年次大会運営事務局
The role of post-translational modification in the regulation of signal transducer and activator of transcription 3 activity Domestic conference
Kojima Hirotada
日本生化学会大会・日本分子生物学会年会合同大会講演要旨集 2015.12 (公社)日本生化学会
STAT3の安定性の調節におけるSTAT3のカルボキシル末端領域の役割(The role of STAT3 C-terminal region in the regulation of STAT3 stability) Domestic conference
楊 俊浩, 小島 裕正, 國本 浩之, 仲野 汐美, 中嶋 弘一
日本生化学会大会プログラム・講演要旨集 2014.10 (公社)日本生化学会
Wakahara Ryohei, Kunimoto Hiroyuki, Kojima Hirotada, Nakajima Koichi
日本免疫学会総会・学術集会記録 2011.11 (NPO)日本免疫学会
サイトカイン・ケモカイン 発現調節とシグナル伝達機構 STAT3 S727のリン酸化はTC45を介してY705チロシン脱リン酸化を制御する(Phospho-Ser727 of STAT3 shortens the duration of STAT3 activity by enhancing the dephosphorylation of pY705 through nuclear TC45) Domestic conference
Wakahara Ryohei, Kunimoto Hiroyuki, Kojima Hirotada, Nakajima Koichi
日本免疫学会総会・学術集会記録 2011.11 (NPO)日本免疫学会
麻疹ウイルスH蛋白の変異による神経病原性および受容体利用能の変化
Grant-in-Aid for Scientific Research(C) 2027
麻疹ウイルスH蛋白の変異による神経病原性および受容体利用能の変化
Grant-in-Aid for Scientific Research(C) 2026
麻疹ウイルスH蛋白の変異による神経病原性およびレセプター利用能の変化
Grant-in-Aid for Scientific Research(C) 2025
麻疹ウイルスH蛋白の変異による神経病原性および受容体利用能の変化
Grant-in-Aid for Scientific Research(C) 2025
麻疹ウイルスH蛋白の変異による神経病原性およびレセプター利用能の変化
Grant-in-Aid for Scientific Research(C) 2024
麻疹ウイルスH蛋白の変異による神経病原性および受容体利用能の変化
Grant-in-Aid for Scientific Research(C) 2024
STAT3による細胞老化誘導とその後のクリアランス機構の解明
Grant-in-Aid for Scientific Research(C) 2013.04
M2講義（細胞生物学コース・免疫学コース），M2分子系実習，M1講義（遺伝と遺伝子コース・遺伝医学コース）
生化学
2024 Weekly class Undergraduate
医学研究推進コース2
2023
医学研究推進コース3
2023
医学研究推進コース2
2022
医学研究推進コース3
2022
生体構造機能学1
2019 Graduate school
細胞生物学コース
2019 Undergraduate
分子系実習
2019 Undergraduate
免疫学コース
2019 Undergraduate
遺伝医学コース
2019 Undergraduate
遺伝と遺伝子コース
2019 Undergraduate
免疫学コース
2018 Undergraduate
遺伝と遺伝子コース
2018 Undergraduate
細胞生物学コース
2018 Undergraduate
生体構造機能学1
2018 Graduate school
分子系実習
2018 Undergraduate
分子系実習
2017 Undergraduate
生体構造機能学1
2017 Graduate school
免疫学コース
2017 Undergraduate
遺伝と遺伝子コース
2017 Undergraduate
サイトカインについて
Category：Modern system science (knowledge information system, environmental system, educational welfare, psychology), Commerce (management, public management), Economics, Law (law, politics, administration), Literature (literature, philosophy, history, art, human behavior, language, culture, society / gender), Science (mathematics, physics, chemistry, biology, geology, biochemistry), Engineering (machinery, electronics / physics, electrical / electronics, electrical information, chemical biotechnology, architecture, cities (civil engineering / environment), material chemistry, aerospace, marine systems, applied chemistry, chemistry, materials), Life sciences (food, nutrition science, living environment, human welfare), Agricultural science (applied biology, biofunctional chemistry, green space environmental science), Medicine (medical care, rehabilitation, health exercise science, physical fitness / training, sports practice science), Nursing (nursing, sex education), Veterinary