Updated on 2024/04/03
Graduate School of Medicine Department of Basic Medical Science
Assistant Professor 2022.04 - Now
School of Medicine Department of Medical Science
Assistant Professor 2022.04 - Now
Ph.D. （ Osaka City University ）
M.Pharm. （ Kyoto Pharmaceutical University ）
Life Science / Molecular biology
Gene expression
Transcription
遺伝子スプライシング制御
Individual
2011 - Now
Regulatory mechanisms of gene transcription by cytokine signals
cytokine, transcription Individual
2003 - Now
THE MOLECULAR BIOLOGY SOCIETY OF JAPAN
Domestic
日本生化学会
Domestic
日本アンドロロジー学会
Domestic
日本免疫学会
Domestic
沢井製薬株式会社 学術部
1996.04 - 1999.03
Osaka City University Immunology Doctor's Course Accomplished credits for doctoral program
- 2003.03
Kyoto Pharmaceutical University Master's Course Graduated/Completed
- 1996.03
Kyoto Pharmaceutical University Pharmacy Bachelor's Course Graduated/Completed
- 1994.03
Sequestration of RBM10 in Nuclear Bodies: Targeting Sequences and Biological Significance. Reviewed
Wang LY, Xiao SJ, Kunimoto H, Tokunaga K, Kojima H, Kimura M, Yamamoto T, Yamamoto N, Zhao H, Nishio K, Tani T, Nakajima K, Sunami K, Inoue A
International journal of molecular sciences 22 ( 19 ) 2021.09
Kunimoto H, Inoue A, Kojima H, Yang J, Zhao H, Tsuruta D, Nakajima K
Genes to cells : devoted to molecular & cellular mechanisms 25 ( 2 ) 100 - 110 2020.02（ ISSN:1356-9597 ）
PhosphoSer727 triggers a multi-step inactivation of STAT3 by rapid dissociation of pY705-SH2 through C-terminal tail modulation. Reviewed
Yang J, Kunimoto H, Katayama B, Zhao H, Shiromizu T, Wang L, Ozawa T, Tomonaga T, Tsuruta D, Nakajima K
International immunology 2019.09（ ISSN:0953-8178 ）
The Molecular Basis of Chemical Chaperone Therapy for Oculocutaneous Albinism Type 1A. Reviewed
Teramae A, Kobayashi Y, Kunimoto H, Nakajima K, Suzuki T, Tsuruta D, Fukai K
The Journal of investigative dermatology 2018.11（ ISSN:0022-202X ）
IL-6-STAT3 signaling and premature senescence. Reviewed
Kojima H, Inoue T, Kunimoto H, Nakajima K
JAK-STAT 2 ( 4 ) e25763 2013.10（ ISSN:2162-3988 ）
S1-1/RBM10: multiplicity and cooperativity of nuclear localisation domains. Reviewed International coauthorship
Xiao SJ, Wang LY, Kimura M, Kojima H, Kunimoto H, Nishiumi F, Yamamoto N, Nishio K, Fujimoto S, Kato T, Kitagawa S, Yamane H, Nakajima K, Inoue A
Biology of the cell 105 ( 4 ) 162 - 174 2013.04（ ISSN:0248-4900 ）
Phospho-Ser727 of STAT3 regulates STAT3 activity by enhancing dephosphorylation of phospho-Tyr705 largely through TC45 Reviewed
Wakahara Ryohei, Kunimoto Hiroyuki, Tanino Kanae, Kojima Hirotada, Inoue Akira, Shintaku Haruo, Nakajima Koichi
GENES TO CELLS 17 ( 2 ) 132 - 145 2012.02（ ISSN:1356-9597 ）
The STAT3-IGFBP5 axis is critical for IL-6/gp130-induced premature senescence in human fibroblasts. International coauthorship
Kojima H, Kunimoto H, Inoue T, Nakajima K
Cell Cycle 11 ( 4 ) 730 - 9 2012.02
Laminin-511, inducer of hair growth, is down-regulated and its suppressor in hair growth, laminin-332 up-regulated in chemotherapy-induced alopecia (vol 58, pg 43, 2010) Reviewed International coauthorship
Imanishi Hisayoshi, Tsuruta Daisuke, Tateishi Chiharu, Sugawara Koji, Paus Ralf, Tsuji Tsutomu, Ishii Masamitsu, Ikeda Kazuo, Kunimoto Hiroyuki, Nakajima Koichi, Jones Jonathan C. R., Kobayashi Hiromi
JOURNAL OF DERMATOLOGICAL SCIENCE 60 ( 1 ) 58 - 58 2010.10（ ISSN:0923-1811 ）
STAT3 regulates Nemo-like kinase by mediating its interaction with IL-6-stimulated TGF beta-activated kinase 1 for STAT3 Ser-727 phosphorylation Reviewed International coauthorship
Kojima H, Sasaki T, Ishitani T, Iemura S, Zhao H, Kaneko S, Kunimoto H, Natsume T, Matsumoto K, Nakajima K
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 102 ( 12 ) 4524 - 4529 2005.03（ ISSN:0027-8424 ）
Region 752-761 of STAT3 is critical for SRC-1 recruitment and Ser727 phosphorylation. Reviewed International coauthorship
Zhao H., Nakajima R., Kunimoto H., Sasaki T., Kojima H. and Nakajima K.
Biochem. Biophys. Res. Commun. 325 541 - 548 2004.12
Proximal promoter polymorphisms of the interleukin-4 receptor alpha are associated with psoriasis in Japan: inverse association pattern compared with atopic dermatitis. Reviewed International coauthorship
Fukai K., Hosomi N., Oiso N., Kato A., Ishii M, Kunimoto H. and Nakajima K
Jounal of Dermatological Science 35 78 - 80 2004.03
Polymorphisms in the promoter of the interleukin-4 receptor alpha chain gene are associated with atopic dermatitis in Japan. Reviewed International coauthorship
Hosomi N., Fukai K., Oiso N., Kato A., Ishii M, Kunimoto H. and Nakajima K.
Journal of Investigative Dermatology 122 ( 3 ) 843 - 845 2004.03
Cytoplasmic c-Fos induced by the YXXQ-derived STAT3 signal requires the co-operative MEK/ERK signal for its nuclear translocation. Reviewed
Higashi N., Kunimoto H., Kaneko S., Sasaki T., Ishii M., Kojima H. and Nakajima K.
Genes to Cells 9 233 - 242 2004.03
IL-6-STAT3 signaling and premature senescence
Hirotada Kojima, Toshiaki Inoue, Hiroyuki Kunimoto, Koichi Nakajima
JAK-STAT 2 ( 4 ) e25763 2013.07
Expression and function of nuclear RNA splicing-regulator RBM10 in CNS and peripheral tissues. Domestic conference
2023.08
Tetramer-based model of STAT3 activation-inactivation Domestic conference
Lingyu Wang, Hong Zhao, Junhao Yang, Hiroyuki Kunimoto, Koichi Nakajima
2019.12
RBM10はHepG2において中心小体複製に関わる新規の調節因子である Domestic conference
國本 浩之, 井上 晃, 趙 虹, 中嶋 弘一
第42回 日本分子生物学会年会 2019.12
Cytokines and chemokines Tetramer-based model of STAT3 activation-inactivation(和訳中) Domestic conference
Wang Lingyu, Zhao Hong, Yang Junhao, Kunimoto Hiroyuki, Nakajima Koichi
日本免疫学会総会・学術集会記録 2019.11 (NPO)日本免疫学会
Dissociation of STAT3 C-terminal tail from its own SH2 is critical for phosphoSer727-dependent STAT3 inactivation Domestic conference
Junhao Yang, Hiroyuki Kunimoto, Hong Zhao, Lingyu Wang, Koichi Nakajima
The 47th Annual Meeting of the Japanese Society for Immunology 2018.12
Cytokines and chemokines-1:Inflammation Dissociation of STAT3 C-terminal tail from its own SH2 is critical for phophoSer727-dependent STAT3 inactivation(和訳中) Domestic conference
Yang Junhao, Kunimoto Hiroyuki, Zhao Hong, Wang Lingyu, Nakajima Koichi
日本免疫学会総会・学術集会記録 2018.12 (NPO)日本免疫学会
Suppression of ectopic assembly of centrioles by nuclear RBM10 Domestic conference
Hiroyuki Kunimoto, Hong Zhao, Akira Inoue, Koichi Nakajima
Consortium of Biological Scienes 2017 2017.12
核内RBM10による中心小体形成の制御機序について Domestic conference
國本 浩之, 趙 虹, 井上 晃, 中嶋 弘一
生命科学系学会合同年次大会 2017.12 生命科学系学会合同年次大会運営事務局
RBM10の活動度を制御する自己調節機構 S1-1 NB-targeting Domestic conference
井上 晃, 國本 浩之, 王 凌宇, 肖 勝軍, 小島 裕正, 山本 隆博, 山本 直樹, 木村 政継, 徳永 和明, 谷 時雄, 中嶋 弘一, 井口 広義
生命科学系学会合同年次大会 2017.12 生命科学系学会合同年次大会運営事務局
Fate decision of activated STAT3 for nuclear accumulation or export through regulated multiple conformational changes International conference
Yang Junhao, Kunimoto Hiroyuki, Katayama Bumpei, Wang Lingyu, Zhao Hong, Ozawa Toshiyuki, Tsuruta Daisuke, Nakajima Koichi
5th Annual Meeting of the International Cytokine & Interferon Society 2017.10
Molecular basis of chemical chaperone therapy for oculocutaneous albinism type1 International conference
Teramae A., Kobayashi Y., Kunimoto H., Nakajima K., Suzuki T., Tsuruta D., Fukai K
International Pigment Cell Conference 2017 2017.08
眼皮膚白皮症1型(OCA1)ナンセンス変異の薬剤によるリードスルー治療の基礎実験 Domestic conference
小林 悠衣, 深井 和吉, 國本 浩之, 中嶋 弘一, 梅香路 綾乃, 鈴木 民夫, 鶴田 大輔
日本皮膚科学会雑誌 2017.05 (公社)日本皮膚科学会
A basic in-vitro study of a novel therapy for oculocutaneous albinism type 1 International conference
Teramae A., Kobayashi Y., Kunimoto H., Nakajima K., Suzuki T., Tsuruta D., Fukai K
76 th Annual meeting Social For investigative Dermatology 2017.04
RBM10過剰発現による増殖抑制機序の解析 Domestic conference
-
第３９回 日本分子生物学会年会 2016.12
レンチウイルスを導入したHeLa細胞におけるチロシナーゼのR77Q、H211Y、およびP431L変異体の細胞内局在の分析(Subcelluar localization of tyrosinase R77Q, H211Y and P431L mutants in lentivirus transfected Hela cells) Domestic conference
Teramae Ayako, Kobayashi Yui, Fukai Kazuyoshi, Kunimoto Hiroyuki, Nakajima Koichi, Tsuruta Daisuke
日本研究皮膚科学会年次学術大会・総会プログラム 2016.12 (一社)日本研究皮膚科学会
Subcelluar localization of tyrosinase R77Q, H211Yand P431L mutants in lentivirus transfected HeLa cells Domestic conference
2016.12
Phospho-Tyr705-independent stabilization of STAT3 dimers in the nucleus by a novel mechanism Domestic conference
2016.12
サイトカインとケモカイン 新たな機序による核におけるSTAT3二量体のphospho-tyr705非依存性安定化(Cytokines and chemokines Phospho-Tyr705-independent stabilization of STAT3 dimers in the nucleus by a novel mechanism) Domestic conference
Yang Junhao, Wang Lingyu, Kunimoto Hiroyuki, Zhao Hong, Nakajima Koichi
日本免疫学会総会・学術集会記録 2016.11 (NPO)日本免疫学会
R77Q、H211Y、P431L変異体におけるチロシナーゼの細胞局在 Domestic conference
-
第27回 日本色素細胞学術大会 2016.11
活性化核内STAT3の不活性化と核外輸送の制御機序-安定化キナーゼとSer727リン酸化の役割 Domestic conference
-
第３９回 日本分子生物学会年会 2016.11
MTHFR遺伝子C677T多型と高ホモシステイン血症に伴ったlivedoid vasculopathy Domestic conference
-
第１１４回 日本皮膚科学会総会 2015.05
MTHFR遺伝子C677T多型と高ホモシステイン血症に伴ったlivedoid vasculopathy Domestic conference
堀口 悠衣, 清水 奈美, 安水 真規子, 鶴田 大輔, 國本 浩之, 深井 和吉
日本皮膚科学会雑誌 2015.04 (公社)日本皮膚科学会
チロシナーゼ遺伝子に新規ミスセンス変異H211Yをホモで認めた眼皮膚白皮症1型の姉妹 Domestic conference
堀口 悠依, 深井 和吉, 梅香路 綾乃, 鶴田 大輔, 阿部 優子, 鈴木 民夫, 國本 浩之, 中嶋 弘一, 佐藤 行人, 田宮 元
日本皮膚科学会雑誌 2014.12 (公社)日本皮膚科学会
STAT3の安定性の調節におけるSTAT3のカルボキシル末端領域の役割(The role of STAT3 C-terminal region in the regulation of STAT3 stability) Domestic conference
楊 俊浩, 小島 裕正, 國本 浩之, 仲野 汐美, 中嶋 弘一
日本生化学会大会プログラム・講演要旨集 2014.10 (公社)日本生化学会
OCA1 白皮症患者の薬物治療―リードスルー効果によるナンセンス変異回避の研究 Domestic conference
-
第１１３回 日本皮膚科学会総会 2014.05
OCA1白皮症患者の薬物治療 リードスルー効果によるナンセンス変異回避の研究 Domestic conference
梅香路 綾乃, 國本 浩之, 中嶋 弘一, 鈴木 民夫, 鶴田 大輔, 深井 和吉
日本皮膚科学会雑誌 2014.04 (公社)日本皮膚科学会
Analysis of the Mechanism of Transcriptional Activation of the RNA-binding Protein RBM10 Domestic conference
2012.12
Wakahara Ryohei, Kunimoto Hiroyuki, Kojima Hirotada, Nakajima Koichi
日本免疫学会総会・学術集会記録 2011.11 (NPO)日本免疫学会
選択的スプライシング制御因子RBM10欠損による精子形成不全の分子機序解明
Grant-in-Aid for Scientific Research(C) 2023.04
マルチオミクスを用いた生体レジリエンスにおける老化統括制御分子の包括的解析
Grant-in-Aid for Scientific Research(C) 2023.04
細胞核ダイナミクスの分子機能に着目した抗核抗体関連精神疾患の解明
Grant-in-Aid for Scientific Research(C) 2023.04
Mutations for life lengthening of pancreatic cancer patients: mechanism and proposed theory for practice
Grant-in-Aid for Scientific Research(C) 2019.04
RNA結合タンパク質RBM10欠損による無精子症の発症機序解明と治療法の探索
Grant-in-Aid for Scientific Research(C) 2019.04
核内STAT3運命決定シグナルの同定
Grant-in-Aid for Scientific Research(C) 2017.04
白皮症の治療－ケミカルシャペロン効果の基礎研究
Grant-in-Aid for Scientific Research(C) 2016.04
選択的スプライシング制御因子RBM10に由来する多様な疾病の一元的細胞病態の解明
Grant-in-Aid for Scientific Research(C) 2015.04
Pharmacological treatment of oculocutaneous albinism type 1 by read-though effect
Grant-in-Aid for Challenging Research (Pioneering)/(Exploratory) 2013.04
メンケス病･フェニルケトン尿症に対する遺伝子治療法の開発
国立研究開発法人日本医療研究開発機構（AMED） 遺伝子・細胞治療研究開発基盤事業 2022.07
病理病態学概論
2024 Graduate school
基礎医学研究推進コース1
2024 Undergraduate
基礎医学研究推進コース2
2024 Undergraduate
基礎医学研究推進コース3
2024 Undergraduate
病理病態学概論
2023 Graduate school
基礎医学研究推進コース1
2023 Undergraduate
基礎医学研究推進コース2
2023 Undergraduate
基礎医学研究推進コース3
2023 Undergraduate
基礎医学研究推進コース2
2022 Undergraduate
基礎医学研究推進コース3
2022 Undergraduate
病理病態学概論
2022 Graduate school
基礎医学研究推進コース1
2022 Undergraduate
修業実習
2021 Undergraduate
分子系実習
2021 Undergraduate
病理病態学概論
2021 Graduate school
基礎医学研究推進コース
2021 Undergraduate
遺伝医学
2021 Undergraduate
分子系実習
2020 Undergraduate
修業実習
2020 Undergraduate
基礎医学研究推進コース
2020 Undergraduate
病理病態学概論
2020 Graduate school
遺伝医学
2020 Undergraduate
病理病態学概論
2019 Graduate school
遺伝と遺伝子コース
2019 Undergraduate
免疫系コース
2019 Undergraduate
修業実習
2019 Undergraduate
分子系実習
2019 Undergraduate
遺伝医学
2019 Undergraduate
分子系実習
2018 Undergraduate
免疫系コース
2018 Undergraduate
遺伝と遺伝子コース
2018 Undergraduate
修業実習
2018 Undergraduate
修業実習
2017 Undergraduate
免疫系コース
2017 Undergraduate
分子系実習
2017 Undergraduate
遺伝と遺伝子コース
2017 Undergraduate
分子系実習
2016 Undergraduate
遺伝と遺伝子コース
2016 Undergraduate
修業実習
2016 Undergraduate
生体構造機能学
2016 Graduate school
分子系実習
2015 Undergraduate
遺伝と遺伝子コース
2015 Undergraduate
生体構造機能学
2015
修業実習
2015 Undergraduate
PBLチュートリアル
2015 Undergraduate
分子系実習
2014 Undergraduate
遺伝と遺伝子コース
2014 Undergraduate
修業実習
2014 Undergraduate
分子系実習
2013 Undergraduate
遺伝と遺伝子コース
2013 Undergraduate
修業実習
2013 Undergraduate
PBLチュートリアル
2011 Undergraduate
2019
foreigners accepted :1
International Students :1
2018
International Students :2
2017
International Students :2
2016
International Students :2
Job title within the department
School of Medicine Department of Medical Science
2024.04 - 2025.03
Job title within the department
School of Medicine Department of Medical Science
2023.04 - 2024.03
Job title within the department
School of Medicine Department of Medical Science
2022.04 - 2023.03
2024
Original item：先端融合研究施設 施設管理
2023
Original item：先端融合研究施設 施設管理
2022
Original item：先端融合研究施設 施設管理