Updated on 2024/02/19

写真a

 
NAKANISHI Takeshi
 
Organization
Graduate School of Engineering Division of Science and Engineering for Materials, Chemistry and Biology Associate Professor
School of Engineering Department of Chemistry and Bioengineering
Title
Associate Professor
Affiliation
Institute of Engineering

Position

  • Graduate School of Engineering Division of Science and Engineering for Materials, Chemistry and Biology 

    Associate Professor  2022.04 - Now

  • School of Engineering Department of Chemistry and Bioengineering 

    Associate Professor  2022.04 - Now

Degree

  • 博士(工学) ( Osaka City University )

Research Areas

  • Life Science / Functional biochemistry  / Protein Engineering

Research Career

  • 自己会合ペプチドを利用したタンパク質の高機能化

    自己会合ペプチド、組換え抗体、分子設計  Individual

    1900.04 

  • 医薬応用を目指した高機能人工抗体の開発

    組換え抗体、抗体医薬、がん  Individual

    1900.04 

Professional Memberships

  • Protein Science Society of Japan

      Domestic

Education

  • Osaka City University   Doctor's Course  

    - 2003

  • Osaka City University     Graduated/Completed

    - 1998

Papers

  • Generation of rat monoclonal antibodies against human epidermal growth factor receptor 2 Reviewed

    Honoka Yamamoto, Takeshi Nakanishi, Kan-Ichiro Ihara, Taro Tachibana, and Chikako Yokoyama

    Monoclon. Antib. Immunodiagn. Immunother.   42 ( 2 )   59 - 64   2023.03

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    Publishing type:Research paper (scientific journal)   International / domestic magazine:International journal  

  • Build-up functionalization of anti-EGFR x anti-CD3 bispecific diabodies by integrating high-affinity mutants and functional molecular formats Reviewed

    Asano Ryutaro, Hosokawa Katsuhiro, Taki Shintaro, Konno Shota, Shimomura Ippei, Ogata Hiromi, Okada Mai, Arai Kyoko, Onitsuka Masayoshi, Omasa Takeshi, Nakanishi Takeshi, Umetsu Mitsuo, Kumagai Izumi

    SCIENTIFIC REPORTS   10 ( 1 )   2020.03( ISSN:2045-2322

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41598-020-61840-3

  • Construction of a circularly connected VHH bispecific antibody (cyclobody) for the desirable positioning of antigen-binding sites Reviewed

    Hemmi Saki, Asano Ryutaro, Kimura Kouki, Umetsu Mitsuo, Nakanishi Takeshi, Kumagai Izumi, Makabe Koki

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   523 ( 1 )   72 - 77   2020.02( ISSN:0006-291X

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    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

    DOI: 10.1016/j.bbrc.2019.12.018

  • Chemically Crosslinked Bispecific Antibodies for Cancer Therapy: Breaking from the Structural Restrictions of the Genetic Fusion Approach Reviewed

    Ueda Asami, Umetsu Mitsuo, Nakanishi Takeshi, Hashikami Kentaro, Nakazawa Hikaru, Hattori Shuhei, Asano Ryutaro, Kumagai Izumi

    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES   21 ( 3 )   2020.02

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.3390/ijms21030711

  • Functional domain order of an anti-EGFR × anti-CD16 bispecific diabody involving NK cell activation Reviewed

    Atsushi Kuwahara, Keisuke Nagai, Takeshi Nakanishi, Izumi Kumagai, and Ryutaro Asano

    Int. J. Mol. Sci.   21   8914   2020

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    Publishing type:Research paper (scientific journal)   International / domestic magazine:International journal  

  • Generation of the rat monoclonal antibody against the extracellular domain of human CD63 by DNA immunization Reviewed

    Liu Xu, Kan-ichiro Ihara, Saori Yoshimura, Daijiro Konno, Akira Tachibana, Takeshi Nakanishi, and Taro Tachibana

    Monoclon. Antib. Immunodiagn. Immunother.   39   74 - 76   2020

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    Publishing type:Research paper (scientific journal)   International / domestic magazine:International journal  

  • Affinity maturation of humanized anti-epidermal growth factor receptor antibody using a modified phage-based open sandwich selection method. Reviewed

    Sanada Hideaki, Kobayashi Kazuki, Oyama Kenji, Maru Takamitsu, Nakanishi Takeshi, Umetsu Mitsuo, Asano Ryutaro, Kumagai Izumi

    Scientific Reports   8   5414   2018.04( ISSN:2045-2322

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    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

    DOI: 10.1038/s41598-018-23796-3

  • Soluble expression in Escherichia coli of a single-domain antibody–tumor necrosis factor α fusion protein specific for epidermal growth factor receptor. Reviewed

    Tomohiro Osaki, Takeshi Nakanishi, Motoshi Aoki, Takahiro Omizu, Daisuke Nishiura, Masaya Kitamura

    Monoclon. Antib. Immunodiagn. Immunother.   37 ( 1 )   20 - 25   2018.02

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    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

  • Photoinduced electron transfer from aromatic amino acids to the excited isoalloxazine in single mutated flavin mononucleotide binding proteins: Effect of the dimer formation on the rate and the electrostatic energy inside the proteins. Reviewed International coauthorship

    Nadtanet Nunthaboot, Kiattisak Lugsanangarm, Arthit Nueangaudom, Somsak Pianwanit, Sirirat Kokpol, Fumio Tanaka, Seiji Taniguchi, Haik Chosrowjan, Takeshi Nakanishi, Masaya Kitamura

    Comput. Theor. Chem.   1108   1 - 9   2017

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    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

  • Conformational difference between two subunits in flavin mononucleotide binding protein dimers from Desulfovibrio vulgaris (MF): Molecular dynamics simulation. Reviewed

    N. Nunthaboot, K. Lugsanangarm, S. Pianwanit, S. Kokpol, F. Tanaka, T. Nakanishi, M. Kitamura

    Comput. Biol. Chem.   64   113 - 125   2016.10

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    Publishing type:Research paper (scientific journal)  

  • Photoinduced electron transfer from aromatic amino acids to the excited isoalloxazine in flavin mononucleotide binding protein. Is the rate in the inverted region of donor – acceptor distance not real? Reviewed

    N. Nunthaboot, K. Lugsanangarm, A. Pianwanit, F. Tanaka, S. Taniguchi, H. Chosrowjan, T. Nakanishi, M. Kitamura et al.

    J. Photochem. Photobiol. A: Chem.   326   60 - 68   2016.07

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    Publishing type:Research paper (scientific journal)  

  • Generation and characterization of rat monoclonal antibodies against epidermal growth factor receptor. Reviewed

    T. Osaki, C.X. Wang, T. Tachibana, M. Azuma, M. Kitamura, T. Nakanishi

    Monoclon. Antib. Immunodiagn. Immunother.   34 ( 6 )   418 - 422   2015.12

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    Publishing type:Research paper (scientific journal)  

  • Development of a bispecific antibody tetramerized through hetero-associating peptides. Reviewed

    T. Osaki, S. Fujisawa, M. Kitaguchi, M. Kitamura, T. Nakanishi

    FEBS J.   282 ( 22 )   4389 - 4401   2015.11

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    Publishing type:Research paper (scientific journal)  

  • Bell-shaped dependence of the rate of ultrafast photoinduced electron transfer from aromatic amino acids to the excited flavin on the donor-acceptor distance in FMN binding proteins Reviewed

    Nunthaboot Nadtanet, Lugsanangarm Kiattisak, Pianwanit Somsak, Kokpol Sirirat, Tanaka Fumio, Taniguchi Seiji, Chosrowjan Haik, Nakanishi Takeshi, Kitamura Masaya

    COMPUTATIONAL AND THEORETICAL CHEMISTRY   1030   9 - 16   2014.02( ISSN:2210-271X

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.comptc.2013.12.014

  • Mechanism of photoinduced electron transfer from tyrosine to the excited flavin in the flavodoxin from Helicobacter pylori. A comparative study with the flavodoxin and flavin mononucleotide binding protein from Desulfovibrio vulgaris (Miyazaki F) Reviewed

    Lugsanangarm Kiattisak, Pianwanit Somsak, Nueangaudom Arthit, Kokpol Sirirat, Tanaka Fumio, Nunthaboot Nadtanet, Ogino Kumiko, Takagi Rikako, Nakanishi Takeshi, Kitamura Masaya, Taniguchi Seiji, Chosrowjan Haik

    JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY   268   58 - 66   2013.09( ISSN:1010-6030

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.jphotochem.2013.06.007

  • Domain order of a bispecific diabody dramatically enhances its antitumor activity beyond structural format conversion: The case of the hEx3 diabody. Reviewed

    R. Asano, T. Kumagai, K. Nagai, H. Sanada, T. Nakanishi, Y. Katayose, M. Unno, T. Kudo, M. Umetsu, I. Kumagai et al.

    Protein Eng. Des. Sel.   26 ( 5 )   359 - 367   2013.05

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  • A Key Factor for Ultrafast Rates of Photoinduced Electron Transfer among Five Flavin Mononucleotide Binding Proteins: Effect of Negative, Positive, and Neutral Charges at Residue 13 on the Rate Reviewed

    Taniguchi Seiji, Chosrowjan Haik, Tanaka Fumio, Nakanishi Takeshi, Sato Shuta, Haruyama Yoshihiro, Kitamura Masaya

    The Chemical Society of Japan BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN   86 ( 3 )   339 - 350   2013.03( ISSN:0009-2673

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    Publishing type:Research paper (scientific journal)  

    Crystal structures of E13K [Glu13 with negative charge in wild type (WT) was replaced by Lys with positive charge] and E13R (Glu13 was replaced by Arg with positive charge) of flavin mononucleotide-binding protein (FMN-bp) from <i>Desulfovibrio vulgaris</i> (Miyazaki F) were determined by X-ray diffraction method. Ultrafast fluorescence dynamics of FMN in these proteins were measured by fluorescence up-conversion. The average lifetimes of E13K and E13R were 0.198 and 0.186 ps, which are compared to the reported lifetimes of WT, E13T (Glu13 was replaced by Thr with neutral charge) and E13Q (Glu13 was replaced by Gln with neutral charge) FMN-bp, 0.220, 0.872, and 1.10 ps, respectively. These ultrashort lifetimes are ascribed to photoinduced electron transfer (ET) from Trp32, Tyr35, and Trp106 to the excited isoalloxazine. The observed lifetimes of the five FMN-bp isoforms were simultaneously analyzed with both Marcus and Hush, and Kakitani and Mataga ET theories, in order to characterize the ET mechanisms. It was concluded that the electrostatic (ES) energy between the photoproducts and ionic charges inside the proteins is a key factor for the ET rate in the flavoproteins.

    DOI: 10.1246/bcsj.20120231

    CiNii Article

  • Development of an affinity-matured humanized anti-epidermal growth factor receptor antibody for cancer immunotherapy. Reviewed

    T. Nakanishi, T. Maru, K. Tahara, H. Sanada, M. Umetsu, R. Asano, I. Kumagai

    Protein Eng. Des. Sel.   26 ( 2 )   113 - 122   2013.02

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    Publishing type:Research paper (scientific journal)  

  • A high-affinity gold-binding camel antibody: Antibody engineering for one-pot functionalization of gold nanoparticles as biointerface molecules. Reviewed

    T. Hattori, M. Umetsu, T. Nakanishi, S. Sawai, S. Kikuchi, R. Asano, I. Kumagai

    Bioconjug. Chem.   23 ( 9 )   1934 - 1944   2012.09

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  • Construction and humanization of a functional bispecific EGFR CD16 diabody using a refolding system Reviewed

    Asano Ryutaro, Nakayama Makoto, Kawaguchi Hiroko, Kubota Tsuguo, Nakanishi Takeshi, Umetsu Mitsuo, Hayashi Hiroki, Katayose Yu, Unno Michiaki, Kudo Toshio, Kumagai Izumi

    FEBS JOURNAL   279 ( 2 )   223 - 233   2012.01( ISSN:1742-464X

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/j.1742-4658.2011.08417.x

  • In vitro and in vivo antitumor effects of recombinant bispecific antibodies based on humanized anti-EGFR antibody Reviewed

    Y. Watanabe, R. Asano, K. Arai, S. Egawa, T. Nakanishi, M. Umetsu, K. Imai, T. Kudo, M. Unno, I. Kumagai et al.

    Oncol. Rep.   26 ( 4 )   949 - 955   2011.10

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  • Biomimetic engineering of modular bispecific antibodies for biomolecule immobilization Reviewed

    H. Watanabe, K. Kanazaki, T. Nakanishi, H. Shiotsuka, S. Hatakeyama, M. Kaieda, T. Imamura, M. Umetsu, I. Kumagai

    Langmuir   27 ( 16 )   9656 - 9561   2011.08

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  • Mechanism of HSV infection through soluble adapter-mediated virus bridging to the EGF receptor Reviewed

    K. Nakano, M. Kobayashi, K. Nakamura, T. Nakanishi, R. Asano, I. Kumagai, M. Kuwano, J.B. Cohen, J.C. Glorioso et al.

    Virology   413 ( 1 )   12 - 18   2011.04

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  • Cytotoxic Enhancement of a Bispecific Diabody by Format Conversion to Tandem Single-chain Variable Fragment (taFv) THE CASE OF THE hEx3 DIABODY Reviewed

    Asano Ryutaro, Ikoma Keiko, Shimomura Ippei, Taki Shintaro, Nakanishi Takeshi, Umetsu Mitsuo, Kumagai Izumi

    JOURNAL OF BIOLOGICAL CHEMISTRY   286 ( 3 )   1812 - 1818   2011.01( ISSN:0021-9258

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1074/jbc.M110.172957

  • Effects of the Disappearance of One Charge on Ultrafast Fluorescence Dynamics of the FMN Binding Protein Reviewed

    Chosrowjan Haik, Taniguchi Seiji, Mataga Noboru, Nakanishi Takeshi, Haruyama Yoshihiro, Sato Shuta, Kitamura Masaya, Tanaka Fumio

    JOURNAL OF PHYSICAL CHEMISTRY B   114 ( 18 )   6175 - 6182   2010.05( ISSN:1520-6106

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/jp912137s

  • High Affinity Anti-inorganic Material Antibody Generation by Integrating Graft and Evolution Technologies POTENTIAL OF ANTIBODIES AS BIOINTERFACE MOLECULES Reviewed

    Hattori Takamitsu, Umetsu Mitsuo, Nakanishi Takeshi, Togashi Takanari, Yokoo Nozomi, Abe Hiroya, Ohara Satoshi, Adschiri Tadafumi, Kumagai Izumi

    JOURNAL OF BIOLOGICAL CHEMISTRY   285 ( 10 )   7784 - 7793   2010.03( ISSN:0021-9258

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1074/jbc.M109.020156

  • Highly enhanced cytotoxicity of a dimeric bispecific diabody, the hEx3 tetrabody Reviewed

    J. Biol. Chem.   285 ( 27 )   20844 - 20849   2010

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  • Application of the Fc fusion format to generate tag-free bispecific diabodies Reviewed

    FEBS J.   277 ( 2 )   477 - 487   2010

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  • Direct and selective immobilization of proteins by means of an inorganic material-binding peptide: Discussion on functionalization in the elongation to material-binding peptide Reviewed

    J. Phys. Chem. B   114 ( 1 )   480 - 486   2010

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  • Contribution of asparagine residues to the stabilization of a proteinaceous antigen-antibody complex, HyHEL-10-hen egg white lysozyme Reviewed

    J. Biol. Chem.   285 ( 10 )   7686 - 7696   2010

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  • Target cell-restricted apoptosis induction by 528scFv-TRAIL fusion protein specific for human EGFR and expressed in Escherichia coli Reviewed

    Int. J. Oncol.   36 ( 5 )   1229 - 1234   2010

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    Publishing type:Research paper (scientific journal)  

  • Integration of PEGylation and refolding for renaturation of recombinant proteins from insoluble aggregates produced in bacteria-Application to a single-chain Fv fragment Reviewed

    J. Biosci. Bioeng.   109 ( 5 )   447 - 452   2010

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    Publishing type:Research paper (scientific journal)  

  • Biotinylated bionanocapsules for displaying diverse ligands toward cell specific delivery Reviewed

    J. Biochem.   146 ( 6 )   867 - 874   2009

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    Publishing type:Research paper (scientific journal)  

  • Cloning and expression of the MutM gene from obligate anaerobic bacterium Desulfovibrio vulgaris (Miyazaki F) Reviewed

    J. Biochem.   145 ( 4 )   525 - 532   2009

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    Publishing type:Research paper (scientific journal)  

  • Human Anti-gold Antibodies BIOFUNCTIONALIZATION OF GOLD NANOPARTICLES AND SURFACES WITH ANTI-GOLD ANTIBODIES Reviewed

    Watanabe Hideki, Nakanishi Takeshi, Umetsu Mitsuo, Kumagai Izumi

    JOURNAL OF BIOLOGICAL CHEMISTRY   283 ( 51 )   36031 - 36038   2008.12( ISSN:0021-9258

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1074/jbc.M805547200

  • Diabody-based recombinant formats of humanized IgG-like bispecific antibody with effective retargeting, of lymphocytes to tumor cells Reviewed

    Asano Ryutaro, Kawaguchi Hiroko, Watanabe Yasuhiro, Nakanishi Takeshi, Umetsu Mitsuo, Hayashi Hiroki, Katayose Yu, Unno Michiaki, Kudo Toshio, Kumagai Izumi

    JOURNAL OF IMMUNOTHERAPY   31 ( 8 )   752 - 761   2008.10( ISSN:1524-9557

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  • Thermodynamic consequences of mutations in Vernier zone residues of a humanized anti-human epidermal growth factor receptor murine antibody-528 Reviewed

    Makabe Koki, Nakanishi Takeshi, Tsumoto Kouhei, Tanaka Yoshikazu, Kondo Hidemasa, Umetsu Mitsuo, Sone Yukiko, Asano Ryutaro, Kumagai Izumi

    JOURNAL OF BIOLOGICAL CHEMISTRY   283 ( 2 )   1156 - 1166   2008.01( ISSN:0021-9258

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1074/jbc.M706190200

  • Nanoparticles with affinity for biopolymer: Bioassisted room-temperature selective multistacking of inorganic particles on biopolymer film Reviewed

    J. Mater. Res.   23 ( 12 )   3241 - 3246   2008

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  • Grafting of material-binding function into antibodies: Functionalization by peptide grafting Reviewed

    Biochem. Biophys. Res. Commun.   365 ( 4 )   751 - 757   2008

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  • Critical contribution of VH-VL interaction to reshaping of an antibody: the case of humanization of anti-lysozyme antibody, HyHEL-10 Reviewed

    Protein Sci.   17 ( 2 )   261 - 270   2008

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  • Preferential heterodimerization of a bispecific diabody based on a humanized anti-EGFR antibody 528 Reviewed

    Protein Eng. Des. Sel.   21 ( 10 )   597 - 603   2008

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  • Diabody-based recombinant formats of humanized IgG-like bispecific antibody with effective retargeting of lymphocytes to tumor cells Reviewed

    J. Immunother.   31 ( 8 )   752 - 761   2008

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  • Structural consequences of mutations in interfacial Tyr residues of a protein antigen-anti body complex - The case of HyHEL-10-HEL Reviewed

    Shiroishi Mitsunori, Tsumoto Kouhei, Tanaka Yoshikazu, Yokota Akiko, Nakanishi Takeshi, Kondo Hidemasa, Kumagai Izumi

    JOURNAL OF BIOLOGICAL CHEMISTRY   282 ( 9 )   6783 - 6791   2007.03( ISSN:0021-9258

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1074/jbc.M605197200

  • Highly effective recombinant format of a humanized IgG-like bispecific antibody for cancer immunotherapy with retargeting of lymphocytes to tumor cells Reviewed

    J. Biol. Chem.   282 ( 38 )   27659 - 27665   2007

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  • Detection of structural changes in a cofactor binding protein by using a wheat germ cell-free protein synthesis system coupled with unnatural amino acid probing Reviewed

    Proteins   67 ( 3 )   643 - 652   2007

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  • Structural evidence for guanidine-protein side chain interactions: crystal structure of CutA from Pyrococcus horikoshii in 3 M guanidine hydrochloride Reviewed

    Biochem.Biophys. Res. Commun.   323 ( 1 )   185 - 191   2004

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  • Structural implications for heavy metal-induced reversible assembly and aggregation of a protein: the case of Pyrococcus horikoshii CutA Reviewed

    FEBS Lett.   556 ( 42738 )   167 - 174   2004

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  • Cloning and expression of the superoxide dismutase gene from the obligate anaerobic bacterium Desulfovibrio vulgaris (Miyazaki F) Reviewed

    J. Biochem.   133 ( 3 )   387 - 393   2003

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  • Cloning and expression of the catalase gene from the anaerobic bacterium Desulfovibrio vulgaris (Miyazaki F) Reviewed

    J. Biochem.   129 ( 3 )   357 - 364   2001

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Books and Other Publications

  • 次世代医薬開発に向けた抗体工学の最前線 ファージ提示系による親和性の向上

    中西 猛,真田英明,熊谷 泉( Role: Joint author)

    シーエムシー出版  2012 

  • 抗体医薬の最前線 抗体ドメインの積み木細工による高機能化と医用への展開

    熊谷 泉,浅野竜太郎,中西 猛( Role: Joint author)

    シーエムシー出版  2007 

MISC

  • Protein-protein interactions and selection: generation of molecule-binding proteins on the basis of tertiary structural information

    FEBS J.   277 ( 9 )   2006 - 2014   2010

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    Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • Recent aspects of antibodylibrary technologies and their future perspectives

    26 ( 3 )   254 - 257   2007

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    Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

Grant-in-Aid for Scientific Research

  • Fc領域ヘテロ会合化を必要としない非対称二重特異性抗体の作製技術開発

    Grant-in-Aid for Scientific Research(C)  2022.04

  • 革新的なバイオ医薬創製に向けた分子連結技術の高度化

    Grant-in-Aid for Scientific Research(C)  2017.04

  • Development of a molecular connection method for generating highly functional antibodies

    Grant-in-Aid for Scientific Research(C)  2013.04

  • Development of a highly efficient method for generating functional antibodies based on grafting natural ligands

    Grant-in-Aid for Young Scientists(B)  2011

  • ボトムアップ的ライブラリー構築による抗体様RNA分解酵素の創製

    Grant-in-Aid for Young Scientists(B)  2009

Charge of on-campus class subject

  • 情報バイオ演習

    2018     Undergraduate

  • 化学バイオ工学演習A

    2018     Undergraduate

  • 生化学Ⅱ

    2018     Undergraduate

  • 蛋白質工学特論

    2018     Graduate school