Updated on 2024/04/11

写真a

 
MIZUSEKI Kenji
 
Organization
Graduate School of Medicine Department of Basic Medical Science Professor
School of Medicine Department of Medical Science
Title
Professor
Affiliation
Institute of Medicine
Homepage
http://researchmap.jp/kenjimizuseki/

Position

  • Graduate School of Medicine Department of Basic Medical Science 

    Professor  2022.04 - Now

  • School of Medicine Department of Medical Science 

    Professor  2022.04 - Now

Degree

  • Ph.D. （ Kyoto University ）

Research Areas

  • Life Science / Neuroscience-general

  • Life Science / Basic brain sciences

  • Life Science / Physiology

  • Life Science / Function of nervous system

  • Life Science / Cognitive and brain science

Research Interests

  • oscillation

  • sleep

  • memory

  • dopamine

  • Prefrontal Cortex

  • Place cells

  • amygdala

  • hippocampus

Research subject summary

  • Coordinated patterns of neural activity spanning broad spatial and temporal scales underlie information processing in the brain. How are these activity patterns generated by intrinsic cellular properties, synaptic interactions, neuromodulatory systems, and network dynamics? How do these activity patterns carry out computational tasks that the brain attempts to perform? How are internally generated, self-organized network activities perturbed by the external world to produce perception and memory? Our goal is to quantitatively characterize and mechanistically explain information processing in terms of neuronal activity dynamics. Possible mechanisms subserving these processes include precisely structured sequences of activity, synchrony within and across brain regions, and dynamic grouping of local and global neuronal assemblies by network oscillations. These possibilities are testable only if we can simultaneously monitor the activities of many neurons and local field potentials in multiple regions of the intact brain at relevant time resolutions. To achieve our goal, we will employ large-scale electrophysiological recordings of neuronal ensembles in the hippocampus and its related structures in rats and mice while they perform various tasks and while at rest. In addition, we will combine in vivo electrophysiology and optogenetics to elucidate pathway- and cell type-specific functions in information processing.

Research Career

Professional Memberships

  • Society for Neuroscience

      Overseas

  • The Japan Neuroscience Society

      Domestic

  • Physiological Society of Japan

      Domestic

Job Career (off-campus)

  • Osaka Metropolitan University Graduate School of Medicine   Department of Physiology   Professor

    2022.04 - Now

  • Osaka City University Graduate School of Medicine   Department of Physiology   Professor

    2015.04 - 2022.03

  • Allen Institute for Brain Science   Neural Coding   Senior Scientist

    2012.09 - 2015.03

  • New York University School of Medicine   Research Assistant Professor

    2012.03 - 2012.09

  • Rutgers University   Center for Molecular and Behavioral Neuroscience   Research Assistant Professor

    2009.03 - 2012.03

  • Rutgers University   Center for Molecular and Behavioral Neuroscience   Postdoctoral Fellow

    2004 - 2012

  • RIKEN, Center for Developmental Biology   Researcher

    2002 - 2004

  • Institute for Frontier Medical Scieneces

    2000 - 2002

▼display all

Education

  • Kyoto University   Physiology   Doctor's Course   Graduated/Completed

    - 2000

  • Kyoto University   Faculty of Medicine     Graduated/Completed

    - 1996

Papers

  • CA3 Circuit Model Compressing Sequential Information in Theta Oscillation and Replay.

    Kuroki S, Mizuseki K

    Neural computation   36 ( 4 )   501 - 548   2024.03（ ISSN:0899-7667 ）

    　More details

  • Distinct manifold encoding of navigational information in the subiculum and hippocampus. Reviewed

    Shinya Nakai, Takuma Kitanishi, Kenji Mizuseki

    Science advances   10 ( 5 )   eadi4471   2024.02

    　More details

    Authorship：Last author,　Corresponding author   Publishing type：Research paper (scientific journal)   International / domestic magazine：International journal  

    The subiculum (SUB) plays a crucial role in spatial navigation and encodes navigational information differently from the hippocampal CA1 area. However, the representation of subicular population activity remains unknown. Here, we investigated the neuronal population activity recorded extracellularly from the CA1 and SUB of rats performing T-maze and open-field tasks. The trajectory of population activity in both areas was confined to low-dimensional neural manifolds homoeomorphic to external space. The manifolds conveyed position, speed, and future path information with higher decoding accuracy in the SUB than in the CA1. The manifolds exhibited common geometry across rats and regions for the CA1 and SUB and between tasks in the SUB. During post-task ripples in slow-wave sleep, population activity represented reward locations/events more frequently in the SUB than in CA1. Thus, the CA1 and SUB encode information distinctly into the neural manifolds that underlie navigational information processing during wakefulness and sleep.

    DOI： 10.1126/sciadv.adi4471

    PubMed

  • Excitation–Inhibition Balance Controls Synchronization in a Simple Model of Coupled Phase Oscillators

    Satoshi Kuroki, Kenji Mizuseki

    2024

    　More details

  • Acquisition of Auditory Discrimination Mediated by Different Processes through Two Distinct Circuits Linked to the Lateral Striatum

    Susumu Setogawa, Takashi Okauchi, Di Hu, Yasuhiro Wada, Keigo Hikishima, Hirotaka Onoe, Kayo Nishizawa, Nobuyuki Sakayori, Hiroyuki Miyawaki, Takuma Kitanishi, Kenji Mizuseki, Yilong Cui, Kazuto Kobayashi

    2023.10

    　More details

    The striatum, the central hub of cortico-basal ganglia loops, contains functionally heterogeneous subregions distinguished by the topographic patterns of structural connectivity. These subregions mediate various processes of procedural learning. However, it remains unclear when and how striatal subregions engage in a new learning of sensory stimulus-based decision-making. Here, we show that the anterior dorsolateral striatum (aDLS) and posterior ventrolateral striatum (pVLS) are activated in a different temporal pattern during the acquisition phase of auditory discrimination learning. The aDLS promotes the behavioral strategy by the stimulus-response association while suppressing those driven by the response-outcome association, and the pVLS is involved in forming and maintaining the stimulus-response strategy. These two subregions exhibit distinct event-related neuronal responses during the learning processes. Our findings demonstrate that aDLS and pVLS neurons integrate the new learning of auditory discrimination in spatiotemporally and functionally different manners.

    DOI： 10.1101/2023.10.19.563198

  • A novel micro-ECoG recording method for recording multisensory neural activity from the parietal to temporal cortices in mice.

    Setogawa S, Kanda R, Tada S, Hikima T, Saitoh Y, Ishikawa M, Nakada S, Seki F, Hikishima K, Matsumoto H, Mizuseki K, Fukayama O, Osanai M, Sekiguchi H, Ohkawa N

    Molecular brain   16 ( 1 )   38   2023.05

    　More details

  • Fast network oscillations during non-REM sleep support memory consolidation.

    Kenji Mizuseki, Hiroyuki Miyawaki

    Neuroscience research   189   3 - 12   2023.04（ ISSN:0168-0102 ）

    　More details

    Publishing type：Research paper (scientific journal)   International / domestic magazine：International journal  

    The neocortex is disconnected from the outside world during sleep, which has been hypothesized to be relevant for synaptic reorganization involved in memory consolidation. Fast network oscillations, such as hippocampal sharp-wave ripples, cortical ripples, and amygdalar high-frequency oscillations, are prominent during non-REM sleep. Although these oscillations are thought to be generated by local circuit mechanisms, their occurrence rates and amplitudes are modulated by thalamocortical spindles and neocortical slow oscillations during non-REM sleep, suggesting that fast network oscillations and slower oscillations cooperatively work to facilitate memory consolidation. This review discusses the recent progress in understanding the generation, coordination, and functional roles of fast network oscillations. Further, it outlines how fast network oscillations in distinct brain regions synergistically support memory consolidation and retrieval by hosting cross-regional coactivation of memory-related neuronal ensembles.

    DOI： 10.1016/j.neures.2022.12.019

    PubMed

  • Impact of tumoral structure and bacterial species on growth and biodistribution of live bacterial therapeutics in xenografted tumours.

    Maiko Takahashi, Erike Widyasari Sukowati, Shoko Nomura, Akari Kato, Kenji Mizuseki, Yasuyoshi Watanabe, Hidefumi Mukai

    Journal of drug targeting   31 ( 2 )   194 - 205   2023.02（ ISSN:1026-7158 ）

    　More details

    Publishing type：Research paper (scientific journal)   International / domestic magazine：International journal  

    Live bacterial therapeutics is gaining attention, especially for cancer therapy, because anaerobic bacteria selectively grow inside the solid tumours. However, the effect of tumour structure and bacterial characteristics on the pharmacokinetics of tumours is unclear; therefore, we aimed to elucidate the effects of tumour structure and types of bacteria on tumoral bacterial growth. Using six mouse xenograft models, including stroma-rich tumours similar to clinical tumours, and two models of live bacterial therapeutics, Salmonella typhimurium VNP20009 and Escherichia coli DH5α, we investigated bacterial growth and distribution in tumours after intravenous administration. Rapid growth of E. coli was observed in HCT116 and other tumours with few collagens, blood vessels not covered by mural cells, and a cancer cell area proliferated disorderly, whereas tumours with contrasting features, such as BxPC-3, showed lower bacterial growth and a limited intratumor distribution. Alternatively, Salmonella typhimurium VNP20009, when successfully proliferated (the probability was approximately 50%), grew to 108 colony forming units/g tissue even in BxPC-3 tumours, and its intratumor distribution was extensive. This study suggests that the development of new methods to modify tumour structure will be essential for the development of anti-tumour clinical therapies based on live bacterial therapeutics.

    DOI： 10.1080/1061186X.2022.2122477

    PubMed

  • A novel micro-ECoG recording method for recording multisensory neural activity from the parietal to temporal cortexes in mice

    Susumu Setogawa, Ryota Kanda, Shuto Tada, Yoshito Saitoh, Mikiko Ishikawa, Satoshi Nakada, Fumiko Seki, Keigo Hikishima, Hideyuki Matsumoto, Kenji Mizuseki, Osamu Fukayama, Makoto Osanai, Hiroto Sekiguchi, Noriaki Ohkawa

    2022.10

    　More details

    Abstract

    Background

    Characterization of inter-regional interactions in brain is essential for understanding the mechanism relevant to normal brain function and neurological disease. The recently developed flexible micro (μ)-electrocorticography (μECoG) device is one prominent method used to examine large-scale cortical activity across multiple regions. The sheet-shaped μECoG electrodes arrays can be placed on a relatively wide area of cortical surface beneath the skull by inserting the device into the space between skull and brain. Although rats and mice are useful tools for neuroscience, current μECoG recording methods in these animals are limited to the parietal region of cerebral cortex. Recording cortical activity from the temporal region of cortex in mice has proven difficult because of surgical barriers created by the skull and surrounding temporalis muscle anatomy.

    New method

    Hear, we developed a sheet-shaped 64-channel μECoG device that allows access to the mouse temporal cortex, and we determined the factor determining the appropriate bending stiffness for the μECoG electrode array. We also established a surgical technique to implant the electrode arrays into the epidural space over a wide area of cerebral cortex covering from the barrel field to olfactory (piriform) cortex, which is the deepest region of the cerebral cortex.

    Results

    Using histology and computed tomography (CT) images, we confirmed that the tip of the μECoG device reached to the most ventral part of cerebral cortex without causing noticeable damage to the brain surface. The device simultaneously recorded somatosensory and odor stimulus-evoked neural activity from dorsal and ventral parts of cerebral cortex in awake and anesthetized mice.

    Conclusions

    These data indicates that our μECoG device and surgical techniques enable to record large-scale cortical activity from the parietal to temporal cortex in mice, including somatosensory and olfactory cortices. This system will provide opportunities to investigate physiological functions from wider areas of the mouse cerebral cortex than those of existing ECoG techniques.

    Highlights

    A 64-channel parylene-based micro-ECoG allows access to the mouse temporal cortex (78 characters)

    Thickness, width, and metal wiring determined bending stiffness of micro-ECoG sheets. (83 characters)

    Micro-ECoG enables the large-scale recordings without structural damage to cortical surface.

    Somatosensory and odor stimulus-evoked activities were recorded simultaneously. (79 characters)

    DOI： 10.1101/2022.10.01.510247

  • Oscillation-coordinated, noise-resistant information distribution via the subiculum.

    Kenji Mizuseki, Takuma Kitanishi

    Current opinion in neurobiology   75   102556 - 102556   2022.08（ ISSN:0959-4388 ）

    　More details

    Authorship：Lead author,　Corresponding author   Publishing type：Research paper (scientific journal)   International / domestic magazine：International journal  

    The hippocampus processes information associated with spatial navigation. The subiculum receives input from the hippocampus CA1 and projects to various cortical and subcortical regions. Thus, the subiculum is uniquely positioned to distribute hippocampal information to a range of brain areas. Subicular neurons fire at higher rates than CA1 neurons and exhibit similarly or more accurately decodable representations of place, speed, and trajectory. These representations are more noise-resistant and advantageous for long-range information transfer. Subicular neurons selectively or uniformly distribute information to target areas, depending on the information type. Theta oscillations and sharp-wave ripples control information broadcasting in a pathway-specific manner. Thus, the subiculum routes accurately decodable, noise-resistant, navigation-associated information to downstream regions.

    DOI： 10.1016/j.conb.2022.102556

    PubMed

  • De novo inter-regional coactivations of preconfigured local ensembles support memory. Reviewed

    Hiroyuki Miyawaki, Kenji Mizuseki

    Nature communications   13 ( 1 )   1272 - 1272   2022.03

    　More details

    Authorship：Last author,　Corresponding author   Publishing type：Research paper (scientific journal)   International / domestic magazine：International journal  

    Neuronal ensembles in the amygdala, ventral hippocampus, and prefrontal cortex are involved in fear memory; however, how inter-regional ensemble interactions support memory remains elusive. Using multi-regional large-scale electrophysiology in the aforementioned structures of fear-conditioned rats, we found that the local ensembles activated during fear memory acquisition are inter-regionally coactivated during the subsequent sleep period, which relied on brief bouts of fast network oscillations. During memory retrieval, the coactivations reappeared, together with fast oscillations. Coactivation-participating-ensembles were configured prior to memory acquisition in the amygdala and prefrontal cortex but developed through experience in the hippocampus. Our findings suggest that elements of a given memory are instantly encoded within various brain regions in a preconfigured manner, whereas hippocampal ensembles and the network for inter-regional integration of the distributed information develop in an experience-dependent manner to form a new memory, which is consistent with the hippocampal memory index hypothesis.

    DOI： 10.1038/s41467-022-28929-x

    PubMed

  • Intersectional, anterograde transsynaptic targeting of neurons receiving monosynaptic inputs from two upstream regions Reviewed

    Takuma Kitanishi, Mariko Tashiro, Naomi Kitanishi, Kenji Mizuseki

    Communications Biology   5 ( 1 )   149 - 149   2022.02

    　More details

    Authorship：Last author,　Corresponding author   Publishing type：Research paper (scientific journal)   International / domestic magazine：International journal  

    <title>Abstract</title>A brain region typically receives inputs from multiple upstream areas. However, currently, no method is available to selectively dissect neurons that receive monosynaptic inputs from two upstream regions. Here, we developed a method to genetically label such neurons with a single gene of interest in mice by combining the anterograde transsynaptic spread of adeno-associated virus serotype 1 (AAV1) with intersectional gene expression. Injections of AAV1 expressing either Cre or Flpo recombinases and the Cre/Flpo double-dependent AAV into two upstream regions and the downstream region, respectively, were used to label postsynaptic neurons receiving inputs from the two upstream regions. We demonstrated this labelling in two distinct circuits: the retina/primary visual cortex to the superior colliculus and the bilateral motor cortex to the dorsal striatum. Systemic delivery of the intersectional AAV allowed the unbiased detection of the labelled neurons throughout the brain. This strategy may help analyse the interregional integration of information in the brain.

    DOI： 10.1038/s42003-022-03096-3

    PubMed

    Other URL： https://www.nature.com/articles/s42003-022-03096-3

  • 海馬支脚から視床前とGudden腹側被蓋核に投射する内側乳頭核ニューロンへの単シナプス接続(Monosynaptic connection from the subiculum to medial mammillary nucleus neurons projecting to the anterior thalamus and Gudden's ventral tegmental nucleus)

    Umaba Ryoko, Kitanishi Takuma, Mizuseki Kenji

    Neuroscience Research   171   1 - 8   2021.10（ ISSN:0168-0102 ）

    　More details

    adeno-associated virus serotype 1(AAV1)による順行性経シナプス標識を用いて、海馬支脚(SUB)神経から単シナプス入力を受けている内側乳頭核(MM)投射神経の特定を試みた。AAV-1-Creを雄性Long-Evansラット(体重307〜341g、手術時の年齢8〜9週)の背側SUBに投与し、enhanced yellow fluorescent protein(EYFP)をコードするCre依存性AAVをMMに投与した。その結果、MMの細胞体および前腹側/前内側視床核とGudden腹側被蓋核の軸索がEYFPで標識された。EYFP発現の特異性を確認するためにAAV1-Creの代わりにリン酸緩衝生理食塩水を背側SUBに、AAV-EYFPをMMに投与したラットではSUBとMMにおけるEYFPの発現は確認されなかった。また、AAV1-Creを背側SUBの皮質表面に投与し、AAV-EYFPをMMに投与したラットではMMにおけるEYFPの発現は確認されなかった。EYFPで標識されたMMの細胞はグルタミン酸とロイシンエンケファリンに対して免疫反応性があり、EYFPで標識されたほとんどの細胞の細胞体はグルタミン酸デカルボキシラーゼ67陽性末端に囲まれていたため、周縁のGABA作動性入力を受けていたことが示唆された。

  • Oscillation-Driven Memory Encoding, Maintenance, and Recall in an Entorhinal-Hippocampal Circuit Model. Reviewed

    Kurikawa T, Mizuseki K, Fukai T

    Cerebral cortex (New York, N.Y. : 1991)   31 ( 4 )   2038 - 2057   2021.03（ ISSN:1047-3211 ）

    　More details

    Publishing type：Research paper (scientific journal)  

    During the execution of working memory tasks, task-relevant information is processed by local circuits across multiple brain regions. How this multiarea computation is conducted by the brain remains largely unknown. To explore such mechanisms in spatial working memory, we constructed a neural network model involving parvalbumin-positive, somatostatin-positive, and vasoactive intestinal polypeptide-positive interneurons in the hippocampal CA1 and the superficial and deep layers of medial entorhinal cortex (MEC). Our model is based on a hypothesis that cholinergic modulations differently regulate information flows across CA1 and MEC at memory encoding, maintenance, and recall during delayed nonmatching-to-place tasks. In the model, theta oscillation coordinates the proper timing of interactions between these regions. Furthermore, the model predicts that MEC is engaged in decoding as well as encoding spatial memory, which we confirmed by experimental data analysis. Thus, our model accounts for the neurobiological characteristics of the cross-area information routing underlying working memory tasks.

    DOI： 10.1093/cercor/bhaa343

    PubMed

  • Robust information routing by dorsal subiculum neurons Reviewed

    Kitanishi Takuma, Umaba Ryoko, Mizuseki Kenji

    SCIENCE ADVANCES   7 ( 11 )   2021.03（ ISSN:2375-2548 ）

    　More details

    Publishing type：Research paper (scientific journal)  

    The dorsal hippocampus conveys various information associated with spatial navigation; however, how the information is distributed to multiple downstream areas remains unknown. We investigated this by identifying axonal projections using optogenetics during large-scale recordings from the rat subiculum, the major hippocampal output structure. Subicular neurons demonstrated a noise-resistant representation of place, speed, and trajectory, which was as accurate as or even more accurate than that of hippocampal CA1 neurons. Speed- and trajectory-dependent firings were most prominent in neurons projecting to the retrosplenial cortex and nucleus accumbens, respectively. Place-related firing was uniformly observed in neurons targeting the retrosplenial cortex, nucleus accumbens, anteroventral thalamus, and medial mammillary body. Theta oscillations and sharp-wave/ripples tightly controlled the firing of projection neurons in a target region-specific manner. In conclusion, the dorsal subiculum robustly routes diverse navigation-associated information to downstream areas.

    DOI： 10.1126/sciadv.abf1913

    PubMed

  • Monosynaptic connection from the subiculum to medial mammillary nucleus neurons projecting to the anterior thalamus and Gudden's ventral tegmental nucleus. Reviewed

    Umaba R, Kitanishi T, Mizuseki K

    Neuroscience research   2021.01（ ISSN:0168-0102 ）

    　More details

    Publishing type：Research paper (scientific journal)  

    As a major hippocampal output structure, the subiculum projects to diverse cortical and subcortical areas, and its projection to the medial mammillary nucleus (MM) has been implicated in memory. Major efferent targets of the MM are the anteroventral and anteromedial thalamic nuclei and Gudden's ventral tegmental nucleus. These projections may play a key role in distributing subicular information. However, it remains unknown whether neurons in the MM that receive monosynaptic input from the subiculum project to these target regions. We addressed this issue with anterograde transsynaptic tracing mediated using adeno-associated virus serotype 1 (AAV1). Injection of AAV1-Cre and a Cre-dependent AAV encoding enhanced yellow fluorescent protein (EYFP) into the rat dorsal subiculum and MM, respectively, labeled the soma of the MM and axons in the anteroventral / anteromedial thalamic nuclei and Gudden's ventral tegmental nucleus with EYFP. The EYFP-positive neurons in the MM were immunoreactive for glutamate and leu-enkephalin and received perisomatic GABAergic inputs. These results revealed monosynaptic projections from the subiculum to MM neurons projecting to the anteroventral / anteromedial thalamic nuclei and Gudden's ventral tegmental nucleus. This monosynaptic connection may support a fast and robust signal flow through the hippocampal-mammillothalamic and hippocampal-mammillotegmental pathways.

    DOI： 10.1016/j.neures.2021.01.006

    PubMed

  • The Medial Septum as a Potential Target for Treating Brain Disorders Associated With Oscillopathies Reviewed

    Yuichi Takeuchi, Anett J. Nagy, Lívia Barcsai, Qun Li, Masahiro Ohsawa, Kenji Mizuseki, Antal Berényi

    Frontiers in Neural Circuits   15 ( 701080 )   701080 - 701080   2021（ ISSN:16625110 ）

    　More details

    Publishing type：Research paper (scientific journal)   International / domestic magazine：International journal  

    The medial septum (MS), as part of the basal forebrain, supports many physiological functions, from sensorimotor integration to cognition. With often reciprocal connections with a broad set of peers at all major divisions of the brain, the MS orchestrates oscillatory neuronal activities throughout the brain. These oscillations are critical in generating sensory and emotional salience, locomotion, maintaining mood, supporting innate anxiety, and governing learning and memory. Accumulating evidence points out that the physiological oscillations under septal influence are frequently disrupted or altered in pathological conditions. Therefore, the MS may be a potential target for treating neurological and psychiatric disorders with abnormal oscillations (oscillopathies) to restore healthy patterns or erase undesired ones. Recent studies have revealed that the patterned stimulation of the MS alleviates symptoms of epilepsy. We discuss here that stimulus timing is a critical determinant of treatment efficacy on multiple time scales. On-demand stimulation may dramatically reduce side effects by not interfering with normal physiological functions. A precise pattern-matched stimulation through adaptive timing governed by the ongoing oscillations is essential to effectively terminate pathological oscillations. The time-targeted strategy for the MS stimulation may provide an effective way of treating multiple disorders including Alzheimer’s disease, anxiety/fear, schizophrenia, and depression, as well as pain.

    DOI： 10.3389/fncir.2021.701080

    PubMed

  • Cell type, sub-region, and layer-specific speed representation in the hippocampal-entorhinal circuit. Reviewed

    Iwase M, Kitanishi T, Mizuseki K

    Scientific reports   10 ( 1 )   1407   2020.01

    　More details

    Publishing type：Research paper (scientific journal)  

    DOI： 10.1038/s41598-020-58194-1

    PubMed

  • Reconstructing neuronal circuitry from parallel spike trains Reviewed

    Kobayashi Ryota, Kurita Shuhei, Kurth Anno, Kitano Katsunori, Mizuseki Kenji, Diesmann Markus, Richmond Barry J., Shinomoto Shigeru

    NATURE COMMUNICATIONS   10 ( 1 )   4468 - 4468   2019.10（ ISSN:2041-1723 ）

    　More details

    Publishing type：Research paper (scientific journal)  

    State-of-the-art techniques allow researchers to record large numbers of spike trains in parallel for many hours. With enough such data, we should be able to infer the connectivity among neurons. Here we develop a method for reconstructing neuronal circuitry by applying a generalized linear model (GLM) to spike cross-correlations. Our method estimates connections between neurons in units of postsynaptic potentials and the amount of spike recordings needed to verify connections. The performance of inference is optimized by counting the estimation errors using synthetic data. This method is superior to other established methods in correctly estimating connectivity. By applying our method to rat hippocampal data, we show that the types of estimated connections match the results inferred from other physiological cues. Thus our method provides the means to build a circuit diagram from recorded spike trains, thereby providing a basis for elucidating the differences in information processing in different brain regions.

    DOI： 10.1038/s41467-019-12225-2

    PubMed

  • Hippocampal Information Processing and Homeostatic Regulation During REM and Non-REM Sleep Reviewed

    Mizuseki K, Miyawaki H

    Handbook of Behavioral Neuroscience   30   49 - 62   2019.08

    　More details

    Publishing type：Research paper (scientific journal)  

  • Mental fatigue is linked with attentional bias for sad stimuli Reviewed

    Watanabe Kyosuke, Sasaki Akihiro T., Tajima Kanako, Mizuseki Kenji, Mizuno Kei, Watanabe Yasuyoshi

    SCIENTIFIC REPORTS   9 ( 1 )   8797   2019.06（ ISSN:2045-2322 ）

    　More details

    Publishing type：Research paper (scientific journal)  

    DOI： 10.1038/s41598-019-45428-0

    PubMed

  • PET imaging of C-11-labeled coenzyme Q(10): Comparison of biodistribution between [C-11]ubiquinol-10 and [C-11]ubiquinone-10 Reviewed

    Watanabe Kyosuke, Nozaki Satoshi, Goto Mild, Kaneko Ken-ichi, Hayashinaka Emi, Irie Satsuki, Nishiyama Akira, Kasai Kazuaki, Fujii Kenji, Wada Yasuhiro, Mizuno Kei, Mizuseki Kenji, Doi Hisashi, Watanabe Yasuyoshi

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   512 ( 3 )   611 - 615   2019.05（ ISSN:0006-291X ）

    　More details

    Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.bbrc.2019.03.073

    PubMed

  • Hippocampal Reactivation Extends for Several Hours Following Novel Experience Reviewed

    Giri Bapun, Miyawaki Hiroyuki, Mizuseki Kenji, Cheng Sen, Diba Kamran

    JOURNAL OF NEUROSCIENCE   39 ( 5 )   866 - 875   2019.01（ ISSN:0270-6474 ）

    　More details

    Publishing type：Research paper (scientific journal)  

    DOI： 10.1523/JNEUROSCI.1950-18.2018

    PubMed

  • Entorhinal Layer II Calbindin-Expressing Neurons Originate Widespread Telencephalic and Intrinsic Projections. Reviewed

    Ohara S, Gianatti M, Itou K, Berndtsson CH, Doan TP, Kitanishi T, Mizuseki K, Iijima T, Tsutsui KI, Witter MP

    Frontiers in systems neuroscience   13   54   2019

    　More details

    Publishing type：Research paper (scientific journal)  

    DOI： 10.3389/fnsys.2019.00054

    PubMed

  • 海馬における経路特異的な情報処理機構の解明 Reviewed

    水関 健司

    (公財)上原記念生命科学財団　上原記念生命科学財団研究報告集   32   1 - 4   2018.12

    　More details

    Publishing type：Research paper (scientific journal)   Kind of work：Single Work  

  • The subiculum: Unique hippocampal hub and more Reviewed

    Matsumoto N, *Kitanishi T, Mizuseki K

    Neuroscience Research   2018.08（ ISSN:0168-0102 ）

    　More details

    Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.neures.2018.08.002

    PubMed

  • Hippocampal information processing across sleep/wake cycles. Reviewed

    *Mizuseki K, Miyawaki H

    Neuroscience research   118   30 - 47   2017.05（ ISSN:0168-0102 ）

    　More details

    Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.neures.2017.04.018

    PubMed

  • Network mechanisms of hippocampal laterality, place coding, and goal-directed navigation. Reviewed

    Kitanishi T, Ito HT, Hayashi Y, Shinohara Y, *Mizuseki K, *Hikida T

    The journal of physiological sciences : JPS   67 ( 2 )   247 - 258   2017.03（ ISSN:1880-6546 ）

    　More details

    Publishing type：Research paper (scientific journal)  

    DOI： 10.1007/s12576-016-0502-z

    PubMed

  • A Comparison of Visual Response Properties in the Lateral Geniculate Nucleus and Primary Visual Cortex of Awake and Anesthetized Mice. Reviewed

    Durand S, Iyer R, Mizuseki K, de Vries S, Mihalas S, *Reid RC

    The Journal of Neuroscience   36 ( 48 )   12144 - 12156   2016.11（ ISSN:0270-6474 ）

    　More details

    Publishing type：Research paper (scientific journal)  

    DOI： 10.1523/JNEUROSCI.1741-16.2016

    PubMed

  • Millisecond timescale synchrony among hippocampal neurons. Reviewed

    Diba K, Amarasingham A, Mizuseki K, *Buzsáki G

    The Journal of Neuroscience : the official journal of the Society for Neuroscience   34 ( 45 )   14984 - 94   2014.11（ ISSN:0270-6474 ）

    　More details

    Publishing type：Research paper (scientific journal)  

    DOI： 10.1523/JNEUROSCI.1091-14.2014

    PubMed

  • Theta phase segregation of input-specific gamma patterns in entorhinal-hippocampal networks. Reviewed

    Schomburg EW, Fernández-Ruiz A, Mizuseki K, Berényi A, Anastassiou CA, Koch C, *Buzsáki G

    Neuron   84 ( 2 )   470 - 85   2014.10（ ISSN:0896-6273 ）

    　More details

    Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.neuron.2014.08.051

    PubMed

  • Spatially distributed local fields in the hippocampus encode rat position. Reviewed

    Agarwal G, Stevenson IH, Berényi A, Mizuseki K, *Buzsáki G, *Sommer FT

    Science (New York, N.Y.)   344 ( 6184 )   626 - 30   2014.05（ ISSN:0036-8075 ）

    　More details

    Publishing type：Research paper (scientific journal)  

    DOI： 10.1126/science.1250444

    PubMed

  • The log-dynamic brain: how skewed distributions affect network operations. Reviewed

    *Buzsáki G, Mizuseki K

    Nature Reviews Neuroscience   15 ( 4 )   264 - 78   2014.04（ ISSN:1471-003X ）

    　More details

    Publishing type：Research paper (scientific journal)  

    DOI： 10.1038/nrn3687

    PubMed

  • Theta oscillations decrease spike synchrony in the hippocampus and entorhinal cortex. Reviewed

    Mizuseki K, *Buzsaki G

    Philosophical Transactions of the Royal Society of London. Series B, Biological sciences   369 ( 1635 )   20120530   2014.02（ ISSN:0962-8436 ）

    　More details

    Publishing type：Research paper (scientific journal)  

    DOI： 10.1098/rstb.2012.0530

    PubMed

  • Comparison of sleep spindles and theta oscillations in the hippocampus. Reviewed

    Sullivan D, Mizuseki K, Sorgi A, *Buzsáki G

    The Journal of Neuroscience : the official journal of the Society for Neuroscience   34 ( 2 )   662 - 74   2014.01（ ISSN:0270-6474 ）

    　More details

    Publishing type：Research paper (scientific journal)  

    DOI： 10.1523/JNEUROSCI.0552-13.2014

    PubMed

  • Millisecond Timescale Synchrony among Hippocampal Neurons.

    Diba,K., Amarasingham,A., Mizuseki,K., and Buzsaki,G.

    J. Neurosci   34   14984 - 14994   2014（ ISSN:0270-6474 ）

    　More details

    Publishing type：Research paper (scientific journal)  

    Millisecond timescale synchrony among hippocampal neurons.

  • Neurosharing: large-scale data sets (spike, LFP) recorded from the hippocampal-entorhinal system in behaving rats. Reviewed

    *Mizuseki K, Diba K, Pastalkova E, Teeters J, Sirota A, *Buzsáki G

    F1000Research   3   98   2014

    　More details

    Publishing type：Research paper (scientific journal)  

    DOI： 10.12688/f1000research.3895.1

    PubMed

  • Theta oscillations decrease spike synchrony in the hippocampus and entorhinal cortex.

    Mizuseki,K., and Buzsaki,G.

    Philos. Trans. R. Soc. Lond B Biol. Sci.   369   20120530   2014

    　More details

    Publishing type：Research paper (scientific journal)  

  • Comparison of sleep spindles and theta oscillations in the hippocampus.

    Sullivan,D., Mizuseki,K., Sorgi,A., and Buzsaki,G.

    J. Neurosci.   34   662 - 674   2014

    　More details

    Publishing type：Research paper (scientific journal)  

  • Spatially distributed local fields in the hippocampus encode rat position.

    Agarwal,G., Stevenson,I.H., Berenyi,A., Mizuseki,K., Buzsaki,G., and Sommer,F.T.

    Science   344   626 - 630   2014

    　More details

    Publishing type：Research paper (scientific journal)  

  • Neurosharing: large-scale data sets (spike, LFP) recorded from the hippocampal-entorhinal system in behaving rats.

    F1000Res.   3   98   2014

    　More details

    Publishing type：Research paper (scientific journal)  

  • Theta phase segregation of input-specific gamma patterns in entorhinal-hippocampal networks.

    Schomburg,E.W., Fernandez-Ruiz,A., Mizuseki,K., Berenyi,A., Anastassiou,C.A., Koch,C., and Buzsaki,G.

    Neuron   84   470 - 485   2014

    　More details

    Publishing type：Research paper (scientific journal)  

  • Preconfigured, skewed distribution of firing rates in the hippocampus and entorhinal cortex. Reviewed

    *Mizuseki K, *Buzsáki G

    Cell Reports   4 ( 5 )   1010 - 21   2013.09

    　More details

    Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.celrep.2013.07.039

    PubMed

  • Preconfigured, skewed distribution of firing rates in the hippocampus and entorhinal cortex.

    Cell Rep.   4   1010 - 1021   2013

    　More details

    Publishing type：Research paper (scientific journal)  

  • Influence of slow oscillation on hippocampal activity and ripples through cortico-hippocampal synaptic interactions, analyzed by a cortical-CA3-CA1 network model. Reviewed

    *Taxidis J, Mizuseki K, Mason R, Owen MR

    Frontiers in Computational Neuroscience   7   3   2013

    　More details

    Publishing type：Research paper (scientific journal)  

    DOI： 10.3389/fncom.2013.00003

    PubMed

  • Influence of slow oscillation on hippocampal activity and ripples through cortico-hippocampal synaptic interactions, analyzed by a cortical-CA3-CA1 network model.

    Taxidis,J., Mizuseki,K., Mason,R., and Owen,M.R.

    Front Comput. Neurosci.   7   3   2013

    　More details

    Publishing type：Research paper (scientific journal)  

  • REM sleep reorganizes hippocampal excitability. Reviewed

    Grosmark AD, Mizuseki K, Pastalkova E, Diba K, *Buzsáki G

    Neuron   75 ( 6 )   1001 - 7   2012.09（ ISSN:0896-6273 ）

    　More details

    Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.neuron.2012.08.015

    PubMed

  • Activity dynamics and behavioral correlates of CA3 and CA1 hippocampal pyramidal neurons. Reviewed

    Mizuseki K, Royer S, Diba K, *Buzsáki G

    Hippocampus   22 ( 8 )   1659 - 80   2012.08（ ISSN:1050-9631 ）

    　More details

    Publishing type：Research paper (scientific journal)  

    DOI： 10.1002/hipo.22002

    PubMed

  • Large-scale recording of neurons by movable silicon probes in behaving rodents. Reviewed

    Vandecasteele M, M S, Royer S, Belluscio M, Berényi A, Diba K, Fujisawa S, Grosmark A, Mao D, Mizuseki K, Patel J, Stark E, Sullivan D, Watson B, *Buzsáki G

    Journal of Visualized Experiments : JoVE   ( 61 )   e3568   2012.03

    　More details

    Publishing type：Research paper (scientific journal)  

    DOI： 10.3791/3568

    PubMed

  • Cross-frequency phase-phase coupling between θ and γ oscillations in the hippocampus. Reviewed

    Belluscio MA, Mizuseki K, Schmidt R, Kempter R, *Buzsáki G

    The Journal of Neuroscience : the official journal of the Society for Neuroscience   32 ( 2 )   423 - 35   2012.01（ ISSN:0270-6474 ）

    　More details

    Publishing type：Research paper (scientific journal)  

    DOI： 10.1523/JNEUROSCI.4122-11.2012

    PubMed

  • Functional connectivity and tuning curves in populations of simultaneously recorded neurons.

    Stevenson, London, Oby, Sachs, Reimer, Englitz, David, Shamma, Blanche, Mizuseki, et al.

    PLoS. Comput. Biol.   8   e1002775   2012

    　More details

    Publishing type：Research paper (scientific journal)  

  • Functional connectivity and tuning curves in populations of simultaneously recorded neurons. Reviewed

    *Stevenson IH, London BM, Oby ER, Sachs NA, Reimer J, Englitz B, David SV, Shamma SA, Blanche TJ, Mizuseki K, Zandvakili A, Hatsopoulos NG, Miller LE, Kording KP

    PLoS Computational Biology   8 ( 11 )   e1002775   2012（ ISSN:1553-734X ）

    　More details

    Publishing type：Research paper (scientific journal)  

    DOI： 10.1371/journal.pcbi.1002775

    PubMed

  • Cross-frequency phase-phase coupling between theta and gamma oscillations in the hippocampus.

    Belluscio,M.A., Mizuseki,K., Schmidt,R., Kempter,R., and Buzsaki,G.

    J. Neurosci.   32   423 - 435   2012

    　More details

    Publishing type：Research paper (scientific journal)  

  • Activity dynamics and behavioral correlates of CA3 and CA1 hippocampal pyramidal neurons.

    Mizuseki,K., Royer,S., Diba,K., and Buzsaki,G.

    Hippocampus   22   1659 - 1680   2012

    　More details

    Publishing type：Research paper (scientific journal)  

  • Large-scale recording of neurons by movable silicon probes in behaving rodents.

    Vandecasteele, Royer, Belluscio, Berenyi, Diba, Fujisawa, Grosmark, Mao, Mizuseki, et al.

    J. Vis. Exp.   e3568   2012

    　More details

    Publishing type：Research paper (scientific journal)  

  • REM sleep reorganizes hippocampal excitability.

    Grosmark,A.D., Mizuseki,K., Pastalkova,E., Diba,K., and Buzsaki,G.

    Neuron   75   1001 - 1007   2012

    　More details

    Publishing type：Research paper (scientific journal)  

  • Hippocampal CA1 pyramidal cells form functionally distinct sublayers. Reviewed

    Mizuseki K, Diba K, Pastalkova E, *Buzsáki G

    Nature Neuroscience   14 ( 9 )   1174 - 81   2011.08（ ISSN:1097-6256 ）

    　More details

    Publishing type：Research paper (scientific journal)  

    DOI： 10.1038/nn.2894

    PubMed

  • Relationships between hippocampal sharp waves, ripples, and fast gamma oscillation: influence of dentate and entorhinal cortical activity. Reviewed

    Sullivan D, Csicsvari J, Mizuseki K, Montgomery S, Diba K, *Buzsáki G

    The Journal of Neuroscience : the official journal of the Society for Neuroscience   31 ( 23 )   8605 - 16   2011.06（ ISSN:0270-6474 ）

    　More details

    Publishing type：Research paper (scientific journal)  

    DOI： 10.1523/JNEUROSCI.0294-11.2011

    PubMed

  • Relationships between hippocampal sharp waves, ripples, and fast gamma oscillation: influence of dentate and entorhinal cortical activity.

    Sullivan,D., Csicsvari,J., Mizuseki,K., Montgomery,S., Diba,K., and Buzsaki,G.

    J. Neurosci.   31   8605 - 8616   2011

    　More details

    Publishing type：Research paper (scientific journal)  

  • Hippocampal CA1 pyramidal cells form functionally distinct sublayers.

    Mizuseki,K., Diba,K., Pastalkova,E., and Buzsaki,G.

    Nat. Neurosci.   14   1174 - 1181   2011

    　More details

    Publishing type：Research paper (scientific journal)  

  • Temporal delays among place cells determine the frequency of population theta oscillations in the hippocampus. Reviewed

    *Geisler C, Diba K, Pastalkova E, Mizuseki K, Royer S, *Buzsáki G

    Proceedings of the National Academy of Sciences of the United States of America   107 ( 17 )   7957 - 62   2010.04（ ISSN:0027-8424 ）

    　More details

    Publishing type：Research paper (scientific journal)  

    DOI： 10.1073/pnas.0912478107

    PubMed

  • Temporal delays among place cells determine the frequency of population theta oscillations in the hippocampus.

    Geisler,C., Diba,K., Pastalkova,E., Mizuseki,K., Royer,S., and Buzsaki,G.

    Proc. Natl. Acad. Sci. U. S. A   107   7957 - 7962   2010

    　More details

    Publishing type：Research paper (scientific journal)  

  • Theta oscillations provide temporal windows for local circuit computation in the entorhinal-hippocampal loop. Reviewed

    Mizuseki K, Sirota A, Pastalkova E, *Buzsáki G

    Neuron   64 ( 2 )   267 - 80   2009.10（ ISSN:0896-6273 ）

    　More details

    Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.neuron.2009.08.037

    PubMed

  • Theta oscillations provide temporal windows for local circuit computation in the entorhinal-hippocampal loop.

    Mizuseki,K., Sirota,A., Pastalkova,E., and Buzsaki,G.

    Neuron   64   267 - 280   2009

    　More details

    Publishing type：Research paper (scientific journal)  

  • Theta-mediated dynamics of spatial information in hippocampus. Reviewed

    *Itskov V, Pastalkova E, Mizuseki K, Buzsaki G, Harris KD

    The Journal of Neuroscience : the official journal of the Society for Neuroscience   28 ( 23 )   5959 - 64   2008.06（ ISSN:0270-6474 ）

    　More details

    Publishing type：Research paper (scientific journal)  

    DOI： 10.1523/JNEUROSCI.5262-07.2008

    PubMed

  • Theta-mediated dynamics of spatial information in hippocampus.

    Itskov,V., Pastalkova,E., Mizuseki,K., Buzsaki,G., and Harris,K.D.

    J. Neurosci.   28   5959 - 5964   2008

    　More details

    Publishing type：Research paper (scientific journal)  

  • Integration and segregation of activity in entorhinal-hippocampal subregions by neocortical slow oscillations. Reviewed

    Isomura Y, Sirota A, Ozen S, Montgomery S, Mizuseki K, Henze DA, *Buzsáki G

    Neuron   52 ( 5 )   871 - 82   2006.12（ ISSN:0896-6273 ）

    　More details

    Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.neuron.2006.10.023

    PubMed

  • Integration and segregation of activity in entorhinal-hippocampal subregions by neocortical slow oscillations.

    Isomura,Y., Sirota,A., Ozen,S., Montgomery,S., Mizuseki,K., Henze,D.A., and Buzsaki,G.

    Neuron   52   871 - 882   2006

    　More details

    Publishing type：Research paper (scientific journal)  

  • One-step induction of neurons from mouse embryonic stem cells in serum-free media containing vitamin B12 and heparin. Reviewed

    Yamazoe H, Kobori M, Murakami Y, Yano K, Satoh M, Mizuseki K, Sasai Y, Iwata H

    Cell transplantation   15 ( 2 )   135 - 45   2006（ ISSN:0963-6897 ）

    　More details

    Publishing type：Research paper (scientific journal)  

    PubMed

  • One-step induction of neurons from mouse embryonic stem cells in serum-free media containing vitamin B12 and heparin.

    Yamazoe,H., Kobori,M., Murakami,Y., Yano,K., Satoh,M., Mizuseki,K., Sasai,Y., and Iwata,H.

    Cell Transplant.   15   135 - 145   2006

    　More details

    Publishing type：Research paper (scientific journal)  

  • Collection of neural inducing factors from PA6 cells using heparin solution and their immobilization on plastic culture dishes for the induction of neurons from embryonic stem cells. Reviewed

    Yamazoe H, Murakami Y, Mizuseki K, Sasai Y, *Iwata H

    Biomaterials   26 ( 28 )   5746 - 54   2005.10（ ISSN:0142-9612 ）

    　More details

    Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.biomaterials.2005.02.021

    PubMed

  • Generation of Rx+/Pax6+ neural retinal precursors from embryonic stem cells. Reviewed

    Ikeda H, Osakada F, Watanabe K, Mizuseki K, Haraguchi T, Miyoshi H, Kamiya D, Honda Y, Sasai N, Yoshimura N, Takahashi M, *Sasai Y

    Proceedings of the National Academy of Sciences of the United States of America   102 ( 32 )   11331 - 6   2005.08（ ISSN:0027-8424 ）

    　More details

    Publishing type：Research paper (scientific journal)  

    DOI： 10.1073/pnas.0500010102

    PubMed

  • Directed differentiation of telencephalic precursors from embryonic stem cells. Reviewed

    Watanabe K, Kamiya D, Nishiyama A, Katayama T, Nozaki S, Kawasaki H, Watanabe Y, Mizuseki K, *Sasai Y

    Nature neuroscience   8 ( 3 )   288 - 296   2005.03（ ISSN:1097-6256 ）

    　More details

    Publishing type：Research paper (scientific journal)  

    DOI： 10.1038/nn1402

    PubMed

  • Distinct effects of caudalizing factors on regional specification of embryonic stem cell-derived neural precursors. Reviewed

    Irioka T, Watanabe K, Mizusawa H, Mizuseki K, *Sasai Y

    Brain Research. Developmental Brain Research   154 ( 1 )   63 - 70   2005.01（ ISSN:0165-3806 ）

    　More details

    Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.devbrainres.2004.10.004

    PubMed

  • Generation of Rx+/Pax6+ neural retinal precursors from embryonic stem cells.

    Ikeda,H., Osakada,F., Watanabe,K., Mizuseki,K., Haraguchi,T., Miyoshi,H., Kamiya,D., et al.

    Proc. Natl. Acad. Sci. U. S. A   102   11331 - 11336   2005

    　More details

    Publishing type：Research paper (scientific journal)  

  • Distinct effects of caudalizing factors on regional specification of embryonic stem cell-derived neural precursors.

    Irioka,T., Watanabe,K., Mizusawa,H., Mizuseki,K., and Sasai,Y.

    Brain Res. Dev. Brain Res.   154   63 - 70   2005

    　More details

    Publishing type：Research paper (scientific journal)  

  • Directed differentiation of telencephalic precursors from embryonic stem cells.

    Watanabe,K., Kamiya,D., Nishiyama,A., Katayama,T., Nozaki,S., Kawasaki,H., Watanabe,Y., Mizuseki,K., and Sasai,Y.

    Nat. Neurosci.   8   288 - 296   2005

    　More details

    Publishing type：Research paper (scientific journal)  

  • Collection of neural inducing factors from PA6 cells using heparin solution and their immobilization on plastic culture dishes for the induction of neurons from embryonic stem cells.

    Yamazoe,H., Murakami,Y., Mizuseki,K., Sasai,Y., and Iwata,H.

    Biomaterials   26   5746 - 5754   2005

    　More details

    Publishing type：Research paper (scientific journal)  

  • Generation of neural crest-derived peripheral neurons and floor plate cells from mouse and primate embryonic stem cells.

    Mizuseki,K., Sakamoto,T., Watanabe,K., Muguruma,K., Ikeya,M., Nishiyama,A., Arakawa,A., et al.

    Proc. Natl. Acad. Sci. U. S. A   100   5828 - 5833   2003

    　More details

    Publishing type：Research paper (scientific journal)  

  • Generation of dopaminergic neurons and pigmented epithelia from primate ES cells by stromal cell-derived inducing activity.

    Kawasaki,H., Suemori,H., Mizuseki,K., Watanabe,K., Urano,F., Ichinose,H., Haruta,M., Takahashi,M., et al.

    Proc. Natl. Acad. Sci. U. S. A   99   1580 - 1585   2002

    　More details

    Publishing type：Research paper (scientific journal)  

  • Requirement of FoxD3-class signaling for neural crest determination in Xenopus.

    Sasai,N., Mizuseki,K., and Sasai,Y.

    Development   128   2525 - 2536   2001

    　More details

    Publishing type：Research paper (scientific journal)  

  • Induction of midbrain dopaminergic neurons from ES cells by stromal cell-derived inducing activity.

    Kawasaki,H., Mizuseki,K., Nishikawa,S., Kaneko,S., Kuwana,Y., Nakanishi,S., Nishikawa,S.I., and Sasai,Y.

    Neuron   28   31 - 40   2000

    　More details

    Publishing type：Research paper (scientific journal)  

  • Requirement of Sox2-mediated signaling for differentiation of early Xenopus neuroectoderm.

    Kishi,M., Mizuseki,K., Sasai,N., Yamazaki,H., Shiota,K., Nakanishi,S., and Sasai,Y.

    Development   127   791 - 800   2000

    　More details

    Publishing type：Research paper (scientific journal)  

  • Xenopus Xenf: an early endodermal nuclear factor that is regulated in a pathway distinct from Sox17 and Mix-related gene pathways.

    Nakatani,J., Mizuseki,K., Tsuda,H., Nakanishi,S., and Sasai,Y.

    Mech. Dev.   91   81 - 89   2000

    　More details

    Publishing type：Research paper (scientific journal)  

  • Xenopus kielin: A dorsalizing factor containing multiple chordin-type repeats secreted from the embryonic midline.

    Matsui,M., Mizuseki,K., Nakatani,J., Nakanishi,S., and Sasai,Y.

    Proc. Natl. Acad. Sci. U. S. A.   97   5291 - 5296   2000

    　More details

    Publishing type：Research paper (scientific journal)  

  • SoxD: an essential mediator of induction of anterior neural tissues in Xenopus embryos.

    Mizuseki,K., Kishi,M., Shiota,K., Nakanishi,S., and Sasai,Y.

    Neuron   21   77 - 85   1998

    　More details

    Publishing type：Research paper (scientific journal)  

  • Xenopus Zic-related-1 and Sox-2, two factors induced by chordin, have distinct activities in the initiation of neural induction.

    Mizuseki,K., Kishi,M., Matsui,M., Nakanishi,S., and Sasai,Y.

    Development   125   579 - 587   1998

    　More details

    Publishing type：Research paper (scientific journal)  

▼display all

Books and Other Publications

  • Handbook of Sleep Research

    Mizuseki K, Miyawaki H（ Role： Sole author ,  Chapter 7. Hippocampal information processing and homeostatic regulation during REM and non-REM Sleep）

    Academic Press/Elsevier  2019 

    　More details

    Book type：Scholarly book

  • ブレインサイエンス・レビュー　2018

    水関健司（睡眠―覚醒のサイクルにおける海馬の情報処理機構、pp.327-358）（ Role： Sole author ,  睡眠―覚醒のサイクルにおける海馬の情報処理機構）

    クバプロ  2018 

    　More details

    Responsible for pages：pp.327-358   Book type：Scholarly book

MISC

  • The log-dynamic brain: how skewed distributions affect network operations.

    Buzsaki,G., and Mizuseki,K.

    Nat. Rev. Neurosci.   15   264 - 278   2014

    　More details

    Publishing type：Article, review, commentary, editorial, etc. (scientific journal)   Kind of work：Single Work  

  • Selective neural induction from ES cells by stromal cell-derived inducing activity and its potential therapeutic application in Parkinson's disease.

    Kawasaki,H., Mizuseki,K., and Sasai,Y.

    Methods Mol. Biol.   185   217 - 227   2002

    　More details

    Publishing type：Article, review, commentary, editorial, etc. (scientific journal)  

  • ノーベル賞の神経科学 John O’Keefe,May-Britt Moser,Edvard I.Moser(2014) 場所ニューロンの発見 Invited

    水関健司

    Clinical Neuroscience   40 ( 8 )   1019 - 1021   2022.08

    　More details

    Authorship：Lead author,　Last author,　Corresponding author   Publishing type：Article, review, commentary, editorial, etc. (scientific journal)  

  • 【ノーベル賞の神経科学】John O'Keefe、May-Britt Moser、Edvard I.Moser(2014)　場所ニューロンの発見

    水関 健司

    Clinical Neuroscience   40 ( 8 )   1019 - 1021   2022.08（ ISSN:0289-0585 ）

  • 海馬台　特有の海馬出力層としての働きと活動様式(The subiculum: Unique hippocampal hub and more) Reviewed

    Matsumoto Nobuyoshi, Kitanishi Takuma, Mizuseki Kenji

    エルゼビア・ジャパン(株)　Neuroscience Research   143   1 - 12   2019.06（ ISSN:0168-0102 ）

    　More details

    Publishing type：Article, review, commentary, editorial, etc. (scientific journal)  

  • 睡眠-覚醒のサイクルにおける海馬の情報処理機構 Reviewed

    水関 健司

    (株)クバプロ　ブレインサイエンス・レビュー   2018   327 - 358   2018.03

    　More details

    Publishing type：Article, review, commentary, editorial, etc. (scientific journal)   Kind of work：Single Work  

  • 【睡眠の謎を解くための最先端のアプローチ】 睡眠/覚醒サイクルにおける海馬情報処理(【Cutting-edge approaches to unwrapping the mysteries of sleep】 Hippocampal information processing across sleep/wake cycles) Reviewed

    Mizuseki Kenji, Miyawaki Hiroyuki

    エルゼビア・ジャパン(株)　Neuroscience Research   118   30 - 47   2017.05（ ISSN:0168-0102 ）

    　More details

    Publishing type：Article, review, commentary, editorial, etc. (scientific journal)  

  • 海馬の側方性、位置コード化、目標指向ナビゲーションのネットワークメカニズム(Network mechanisms of hippocampal laterality, place coding, and goal-directed navigation) Reviewed

    Kitanishi Takuma, Ito Hiroshi T., Hayashi Yuichiro, Shinohara Yoshiaki, Mizuseki Kenji, Hikida Takatoshi

    (一社)日本生理学会　The Journal of Physiological Sciences   67 ( 2 )   247 - 258   2017.03（ ISSN:1880-6546 ）

    　More details

    Publishing type：Article, review, commentary, editorial, etc. (scientific journal)  

  • Multiple single unit recordings from different rat hippocampal and entorhinal regions while the animals were performing multiple behavioral tasks Reviewed

    Mizuseki K, Sirota, Pastalkova E, Diba K, Buzsáki G

    http://crcns.org/data-sets/hc/hc-3   2014

    　More details

    Publishing type：Article, review, commentary, editorial, etc. (scientific journal)  

  • Theta oscillations provide temporal windows for local circuit computation in the entorhinal-hippocampal loop Reviewed

    Kenji Mizuseki, Gyoergy Buzsaki

    ELSEVIER IRELAND LTD　NEUROSCIENCE RESEARCH   65   S60 - S60   2009（ ISSN:0168-0102 ）

    　More details

    Publishing type：Article, review, commentary, editorial, etc. (scientific journal)  

    DOI： 10.1016/j.neures.2009.09.169

  • Generation of Rx(+)/Pax6(+) neural retinal precursors from embryonic stem cells Reviewed

    H. Ikeda, F. Osakada, K. Watanabe, K. Mizuseki, H. Miyoshi, Y. Honda, N. Yoshimura, M. Takahashi, Y. Sasai

    ELSEVIER SCIENCE BV　MECHANISMS OF DEVELOPMENT   122   S130 - S130   2005.09（ ISSN:0925-4773 ）

    　More details

    Publishing type：Article, review, commentary, editorial, etc. (scientific journal)  

▼display all

Presentations

  • Memory-supporting inter-regional networks among local cellensembles developed in experience dependent manner(和訳中)

    Miyawaki Hiroyuki, Mizuseki Kenji

    The Journal of Physiological Sciences  2022.12  (一社)日本生理学会

  • Mereological approach for understanding the brain　Representation of fear memory by inter-regional coactivations of local cell assemblies(和訳中)

    Mizuseki Kenji

    The Journal of Physiological Sciences  2022.12  (一社)日本生理学会

  • 海馬台における空間情報の表現と情報ルーティング Invited

    千里ライフサイエンスセミナーT4 脳の情報処理研究の最前線：神経コーディングやオシレーションを中心として  2022.11 

    　More details

    Presentation type：Symposium, workshop panel (nominated)  

  • 大規模電気生理学と光遺伝学を用いた 海馬の記憶メカニズムの解明 Invited

    共創の場形成支援プログラム COI-NEXT政策重点分野（バイオ分野）世界モデルとなる自律成長型人材・技術を 育む総合健康産業都市拠点 先端医科学研究セミナー  2022.10 

    　More details

    Presentation type：Public lecture, seminar, tutorial, course, or other speech  

  • 睡眠中の脳領域横断的な同期活動が記憶を支える Invited

    水関健司

    日本睡眠学会第47回定期学術集会 シンポジウム24-2 そもそも睡眠とは何か？~睡眠の基礎研究の未来を多様な視  2022.07 

    　More details

    Presentation type：Oral presentation (invited, special)  

  • そもそも睡眠とは何か?〜睡眠の基礎研究の未来を多様な視点から論じる〜　睡眠中の脳領域横断的な同期活動が記憶を支える

    水関 健司

    日本睡眠学会定期学術集会プログラム・抄録集  2022.06  (一社)日本睡眠学会

  • Representation of fear memory by inter-regional coactivations of local cell assemblies Invited

    Kenji Mizuseki

    The 99th Annual Meeting of the Physiological Society of Japan  2022.03 

    　More details

    Presentation type：Symposium, workshop panel (public)  

  • 海馬-嗅内皮質における細胞種・領域特異的な速度表現

    岩瀬 元貞, 北西 卓磨, 水関 健司

    大阪市医学会雑誌  2021.12  大阪市医学会

  • 小動物用脳波記録シートの開発(Development of brain wave recording sheet for small animal)

    Setogawa Susumu, Iwanaga Kosuke, Tada Shuto, Saito Yoshito, Ishikawa Mikiko, Matsumoto Hideyuki, Mizuseki Kenji, Sekiguchi Hiroto, Ohkawa Noriaki

    The Journal of Physical Fitness and Sports Medicine  2021.11  (一社)日本体力医学会

  • 恐怖記憶を支える海馬・扁桃体・前頭前野の セル・アセンブリ同期活動 Invited

    Kenji Mizuseki

    2021.09 

    　More details

    Presentation type：Symposium, workshop panel (nominated)  

  • Mereological approach for unraveling the structure - function relationship of the central nervous system　海馬台からの投射先特異的な情報分配メカニズム(Representation of fear memory by inter-regional coactivation of local cell assemblies)

    Mizuseki Kenji

    The Journal of Physiological Sciences  2021.08  (一社)日本生理学会

  • 恐怖記憶を支える脳領域横断的なセル・アンサンブルの同期活動の多領域同時・大規模電気生理学記録法を用いた解析(Multi-regional large-scale electrophysiology revealed that inter-regional coactivations of cell ensembles support fear memory)

    Miyawaki Hiroyuki, Mizuseki Kenji

    The Journal of Physiological Sciences  2021.08  (一社)日本生理学会

  • 海馬台からの経路選択的な情報送出　投射先を光同定した大規模活動計測による解析(Projection-identified large-scale recording reveals pathway-specific information outflow from the subiculum)

    Kitanishi Takuma, Umaba Ryoko, Mizuseki Kenji

    The Journal of Physiological Sciences  2021.08  (一社)日本生理学会

  • 空間認識を支える脳情報の流れ

    北西 卓磨, 水関 健司

    日本生理学雑誌  2021.08  (一社)日本生理学会

  • Pathway-specific information outflow from the subiculum Domestic conference

    Kenji Mizuseki

    The 98th annual meeting of the Physiological Society of Japan  2021.03 

    　More details

    Presentation type：Oral presentation (general)  

  • In vivo large-scale electrophysiology Domestic conference

    Kenji Mizuseki

    In vivo large-scale electrophysiology  2020.12 

    　More details

    Presentation type：Oral presentation (general)  

  • Robust information routing by dorsal subiculum neurons Domestic conference

    Kenji Mizuseki

    Kumamoto University Program for Leading Graduate Schools: HIGO program cutting-edge seminar  2020.09 

    　More details

    Presentation type：Oral presentation (general)  

  • Robust information routing by dorsal subiculum neurons Domestic conference

    Kenji Mizuseki

    The 43rd Annual Meeting of the Japan Neuroscience Society  2020.07 

    　More details

    Presentation type：Oral presentation (general)  

  • 大規模電気生理学と光遺伝学を用いた海馬の情報処理機構の解明 Domestic conference

    水関 健司

    第10回 アルツハイマー病とてんかんを考える会 〜基礎から臨床まで〜  2020.02 

    　More details

    Presentation type：Oral presentation (general)  

  • 大規模計測と光遺伝学を用いた海馬の領域間情報伝達の解明 Domestic conference

    水関健司

    第18回 関西バイオ創薬研究会  2019.11 

    　More details

    Presentation type：Oral presentation (general)  

  • 大規模電気生理学と光遺伝学を用いた海馬の情報処理機構の解明 Domestic conference

    水関健司

    理化学研究所 生命機能科学研究センター 生体イメージングサイエンスセミナー  2019.11 

    　More details

    Presentation type：Oral presentation (general)  

  • 恐怖記憶の獲得・固定・想起・消去の基盤となる神経ダイナミクス Domestic conference

    水関健司

    大阪大学蛋白質研究所セミナー 精神疾患の分子・回路病態研究の最前線  2019.11 

    　More details

    Presentation type：Oral presentation (general)  

  • Pathway-specific information outflow from the subiculum Domestic conference

    Kenji Mizuseki

    New York University  2019.10 

    　More details

    Presentation type：Oral presentation (general)  

  • Pathway-specific information processing in the subiculum across sleep/wake cycles. Domestic conference

    Kenji Mizuseki

    Annual Meeting of the Japan Neuroscience Society  2019.07 

    　More details

    Presentation type：Oral presentation (general)  

  • Speed representation in the hippocampus and entorhinal cortex(和訳中) Domestic conference

    Iwase Motosada, Kitanishi Takuma, Mizuseki Kenji

    The Journal of Physiological Sciences  2019.06  (一社)日本生理学会

    　More details

    Presentation type：Oral presentation (general)  

  • 海馬および嗅内皮質の速度表現(Speed representation in the hippocampus and entorhinal cortex)

    Iwase Motosada, Kitanishi Takuma, Mizuseki Kenji

    The Journal of Physiological Sciences  2019.06  (一社)日本生理学会

  • 海馬・扁桃体・前頭前野による記憶と行動決定のメカニズム Domestic conference

    水関健司

    遺伝研研究会　遺伝要因と環境の相互作用による行動決定のメカニズム  2018.09 

    　More details

    Presentation type：Oral presentation (general)  

  • 海馬の神経回路における情報処理機構 Domestic conference

    水関健司

    名古屋大学　環境医学研究所セミナー  2018.04 

    　More details

    Presentation type：Oral presentation (general)  

  • Regulation of neuronal excitability by REM sleep Domestic conference

    Kenji Mizuseki

    Grant-in-Aid for Scientific Research on Innovative Areas, “Principles of memory dynamism elucidated from a diversity of learning systems” 2018 workshop and Meeting  2018.03 

    　More details

    Presentation type：Oral presentation (general)  

  • Temporal coordination of neuronal activity in the entorhinal-hippocampal loop Domestic conference

    Kenji Mizuseki

    The 4th CiNet Conference - Functional and anatomical connectivity, Center for Information and Neural Networks (CiNet)  2018.02 

    　More details

    Presentation type：Oral presentation (general)  

  • 海馬の神経回路における情報処理機構 Domestic conference

    水関健司

    大阪大学大学院生命機能研究科　生命機能研究科セミナー  2017.07 

    　More details

    Presentation type：Oral presentation (general)  

  • 海馬の情報処理機構 Domestic conference

    水関健司

    大阪市立大学　第3回　杉本・阿倍野ライフサイエンス談話会  2017.07 

    　More details

    Presentation type：Oral presentation (general)  

  • 睡眠時における海馬の情報処理機構 Domestic conference

    水関健司

    日本睡眠学会　シンポジウム　睡眠神経科学の最前線  2017.06  日本睡眠学会

    　More details

    Presentation type：Oral presentation (general)  

  • 睡眠神経科学の最前線 睡眠時における海馬の情報処理機構 Domestic conference

    水関 健司

    日本睡眠学会定期学術集会プログラム・抄録集  2017.06  (一社)日本睡眠学会

    　More details

    Presentation type：Oral presentation (general)  

  • 海馬体神経回路の機能発現のメカニズム Domestic conference

    水関健司

    和歌山県立医科大学　大学院特別講義  2016.12 

    　More details

    Presentation type：Oral presentation (general)  

  • Information processing in the entorhinal-hippocampal circuit Domestic conference

    Kenji Mizuseki

    National Institute for Physiological Sciences International Symposium "Towards elucidation of memory engram", Okazaki  2016.12 

    　More details

    Presentation type：Oral presentation (general)  

  • 海馬・嗅内皮質の情報処理機構 Domestic conference

    水関健司

    日本麻酔科学会　第62回関西支部学術集会　特別講演  2016.09  日本麻酔科学会

    　More details

    Presentation type：Oral presentation (general)  

    Venue：大阪、大阪国際物流センター  

  • Hippocampal CA1 pyramidal cells form functionally distinct sublayers. Domestic conference

    Kenji Mizuseki

    The Japan Neuroscience Society, Symposium “Network dissection of hippocampal function”  2016.07  The Japan Neuroscience Society

    　More details

    Presentation type：Oral presentation (general)  

    Venue：Yokohama  

  • 海馬・嗅内皮質の情報処理機構 Domestic conference

    水関健司

    東京大学医学部 機能生物学セミナー  2016.07 

    　More details

    Presentation type：Oral presentation (general)  

  • 海馬体神経回路の情報処理機構 Domestic conference

    水関健司

    RIKEN Center for Life Science Technologies, RIKEN Molecular Imaging Seminar  2016.06 

    　More details

    Presentation type：Oral presentation (general)  

  • Temporal coordination of neuronal activity in the entorhinal-hippocampal circuit Domestic conference

    Kenji Mizuseki

    Korea Institute of Science and Technology Seminar  2016.04 

    　More details

    Presentation type：Oral presentation (general)  

  • Preconfigured, skewed distribution of firing rates in the hippocampus and entorhinal cortex. Domestic conference

    Kenji Mizuseki

    Preconfigured, skewed distribution of firing rates in the hippocampus and entorhinal cortex.  2016.03  The Physiological Society of Japan

    　More details

    Presentation type：Oral presentation (general)  

    Venue：Sapporo  

  • 神経回路の階層的情報処理にアプローチする先端的手法 海馬体の神経細胞の発火頻度は対数正規分布を示す(Leading methodologies for uncovering hierarchical information processing of neuronal circuits Preconfigured, skewed distribution of firing rates in the hippocampus and entorhinal cortex) Domestic conference

    Mizuseki Kenji

    The Journal of Physiological Sciences  2016.03  (一社)日本生理学会

    　More details

    Presentation type：Oral presentation (general)  

  • 海馬体の神経細胞の発火頻度は対数正規分布を示す Domestic conference

    水関 健司

    日本生理学雑誌  2016.01  (一社)日本生理学会

    　More details

    Presentation type：Oral presentation (general)  

  • 多点同時記録法を用いた海馬体の神経回路解析 Domestic conference

    水関健司

    生理学研究所研究会『大脳皮質の機能原理を探る』  2015.12 

    　More details

    Presentation type：Oral presentation (general)  

  • 海馬体神経回路の情報処理機構 Domestic conference

    水関健司

    京都大学大学院医学研究科セミナー  2015.11 

    　More details

    Presentation type：Oral presentation (general)  

  • Temporal coordination of neuronal activity in the entorhinal-hippocampal circuit Domestic conference

    Kenji Mizuseki

    Kyoto University Graduate School of Medicine  2015.10 

    　More details

    Presentation type：Oral presentation (general)  

  • 多点同時記録法を用いたラット海馬体の神経回路解析 Domestic conference

    水関健司

    生理学研究所研究会　記憶回路研究会『異なる動物種間での記憶回路制御機構の統合的理解による記憶回路原理の解明』  2015.10 

    　More details

    Presentation type：Oral presentation (general)  

  • Temporal coordination of neuronal activity in the entorhinal-hippocampal circuit Domestic conference

    水関健司

    大阪市立大学大学院医学研究科　神経放射線病理カンファレンス  2015.07 

    　More details

    Presentation type：Oral presentation (general)  

  • 多点同時記録法を用いた海馬体の神経回路解析 Domestic conference

    水関健司

    京都大学大学院医学研究科メディカルイノベーションセンター　セミナー  2015.06 

    　More details

    Presentation type：Oral presentation (general)  

  • 海馬体神経回路の機能発現のメカニズム Domestic conference

    水関健司

    大阪市立大学医学部セミナー  2014.10 

    　More details

    Presentation type：Oral presentation (general)  

  • Temporal coordination of neuronal activity in the entorhinal-hippocampal circuit Domestic conference

    Kenji Mizuseki

    University of Washington, Graduate Program in Neurobiology and Behavior  2014.06  University of Washington, Graduate Program in Neurobiology and Behavior

    　More details

    Presentation type：Oral presentation (general)  

    Venue：Seattle, WA, U.S.A.  

  • 海馬体神経回路の機能発現のメカニズム Domestic conference

    水関健司

    大阪大学医学部セミナー  2014.03 

    　More details

    Presentation type：Oral presentation (general)  

  • Temporal coordination of neuronal activity in the entorhinal-hippocampal circuit Domestic conference

    Kenji Mizuseki

    National Institute for Physiological Sciences Seminar  2013.12 

    　More details

    Presentation type：Oral presentation (general)  

  • Temporal coordination of neuronal activity in the entorhinal-hippocampal circuit Domestic conference

    Kenji Mizuseki

    International Institute for Integrative Sleep Medicine Seminar  2013.12 

    　More details

    Presentation type：Oral presentation (general)  

  • 海馬体神経回路の機能発現のメカニズム Domestic conference

    水関健司

    国立遺伝学研究所研究会『哺乳類脳の機能的神経回路の構築メカニズム』  2013.12 

    　More details

    Presentation type：Oral presentation (general)  

  • 多点同時記録法を用いた海馬体の神経回路解析 Domestic conference

    水関健司

    玉川大学脳科学研究所セミナー  2013.12 

    　More details

    Presentation type：Oral presentation (general)  

  • Temporal coordination of neuronal activity in the entorhinal-hippocampal circuit Domestic conference

    Kenji Mizuseki

    Department of Neurobiology & Behavior, University of California, Irvine, CA, U.S.A.  2012.03 

    　More details

    Presentation type：Oral presentation (general)  

  • Temporal coordination of neuronal activity in the entorhinal-hippocampal circuit Domestic conference

    Kenji Mizuseki

    Department of Neurobiology and Anatomy, The University of Texas Health Science Center at Houston, TX, U.S.A.  2012.02 

    　More details

    Presentation type：Oral presentation (general)  

  • Temporal coordination of neuronal activity in the entorhinal-hippocampal circuit Domestic conference

    Kenji Mizuseki

    A*STAR Neuroscience Research Partnership, Singapore  2012.02 

    　More details

    Presentation type：Oral presentation (general)  

  • Temporal coordination of neuronal activity in the entorhinal-hippocampal circuit Domestic conference

    Kenji Mizuseki

    Duke-NUS Graduate Medical School, Singapore  2012.02 

    　More details

    Presentation type：Oral presentation (general)  

  • Temporal coordination of neuronal activity in the entorhinal-hippocampal circuit Domestic conference

    Kenji Mizuseki

    Tohoku University, G-COE seminar  2012.01 

    　More details

    Presentation type：Oral presentation (general)  

  • 海馬体神経回路の機能発現のメカニズム Domestic conference

    水関健司

    東北大学医学部セミナー  2012.01 

    　More details

    Presentation type：Oral presentation (general)  

  • 海馬体神経回路の機能発現のメカニズム Domestic conference

    水関健司

    京都大学医学部セミナー  2012.01 

    　More details

    Presentation type：Oral presentation (general)  

  • 海馬体神経回路の機能発現のメカニズム Domestic conference

    水関健司

    東京大学医学部セミナー  2012.01 

    　More details

    Presentation type：Oral presentation (general)  

  • Temporal coordination of neuronal activity in the entorhinal-hippocampal circuit Domestic conference

    Kenji Mizuseki

    RIKEN, Brain Science Institute Seminar  2012.01 

    　More details

    Presentation type：Oral presentation (general)  

  • Temporal coordination of neuronal activity in the entorhinal-hippocampal circuit Domestic conference

    Kenji Mizuseki

    Harvard Medical School, Boston, MA, U.S.A.  2011.12 

    　More details

    Presentation type：Oral presentation (general)  

  • Temporal coordination of neuronal activity in the entorhinal-hippocampal circuit Domestic conference

    Kenji Mizuseki

    Allen Institute for Brain Science, Seattle, WA, U.S.A.  2011.08 

    　More details

    Presentation type：Oral presentation (general)  

  • Temporal coordination of neuronal activity in the entorhinal-hippocampal circuit Domestic conference

    Kenji Mizuseki

    Medical University of South Carolina, Charleston, SC, U.S.A.  2011.04 

    　More details

    Presentation type：Oral presentation (general)  

  • Theta oscillations provide temporal windows for local circuit computation in the entorhinal-hippocampal loop Domestic conference

    Kenji Mizuseki

    The 32nd Annual Meeting of the Japan Neuroscience Society, Nagoya, Japan  2009.09 

    　More details

    Presentation type：Oral presentation (general)  

  • Theta oscillations provide temporal windows for local circuit computation in the entorhinal-hippocampal loop Domestic conference

    Kenji Mizuseki

    National Institute for Physiological Sciences Seminar  2009.09 

    　More details

    Presentation type：Oral presentation (general)  

  • Theta oscillations provide temporal windows for local circuit computation in the entorhinal-hippocampal loop Domestic conference

    Kenji Mizuseki

    Kyoto University, Faculty of Medicine, Kyoto, Japan  2009.09 

    　More details

    Presentation type：Oral presentation (general)  

  • Theta oscillations provide temporal windows for local circuit computation in the entorhinal-hippocampal loop Domestic conference

    Kenji Mizuseki

    Osaka Bioscience Institute, Suita, Japan  2009.09 

    　More details

    Presentation type：Oral presentation (general)  

▼display all

Grant-in-Aid for Scientific Research

  • 海馬から他の脳領域への情報分配メカニズムの解明

    Grant-in-Aid for Scientific Research(B)  2020.04

  • 恐怖記憶の獲得・固定・想起・消去の基盤となる神経ダイナミクスの解明

    新学術領域研究(研究領域提案型)  2019.04

  • 海馬台における投射先特異的な情報処理機構の解明

    新学術領域研究(研究領域提案型)  2018.04

  • 多点同時記録と光操作の融合による単一神経細胞の入出力解析法の開発

    挑戦的研究(萌芽)  2017.06

  • 神経活動の可塑性と記憶におけるレム睡眠の役割

    新学術領域研究(研究領域提案型)  2016.06

  • 海馬体神経回路の細胞種・経路特異的な情報処理機構

    Grant-in-Aid for Scientific Research(B)  2016.04

  • 海馬体の領域間・細胞間の動的相互作用

    Grant-in-Aid for Research Activity Start-up  2015.08

  • Generation of region-specific neural cells from Embryonic Stem Cells

    Grant-in-Aid for Scientific Research(C)  2001

  • 神経分化誘導因子SDIA分子同定と再生医学的応用

    Grant-in-Aid for Scientific Research on Priority Areas  2001

  • Generation of region-specific neural cells from Embryonic Stem Cells

    Grant-in-Aid for Scientific Research(C)  2001

  • 神経分化誘導因子SDIA分子同定と再生医学的応用

    Grant-in-Aid for Scientific Research on Priority Areas  2001

  • 哺乳類ES細胞から特定のニューロンへの分化決定

    Grant-in-Aid for JSPS Fellows  2000

  • 哺乳類ES細胞から特定のニューロンへの分化決定

    Grant-in-Aid for JSPS Fellows  2000

▼display all

Incentive donations / subsidies

  • 海馬における投射先特異的な情報処理機構の解明

    武田科学振興財団  2018

  • 大規模記録法と光科学技術の融合による単一神経細胞の入出力演算解析法の開発

    双葉電子記念財団  2017.04

  • 海馬における経路特異的な情報処理機構の解明

    ノバルティス科学振興財団  2017

  • 情報科学と神経生理学の融合による海馬における他者の表現の解明

    旭硝子財団  2016.04

  • 海馬台主細胞による投射先特異的情報ルーティング

    東レ科学振興会  2016.04

  • 海馬台主細胞による投射先特異的情報ルーティング

    ライフサイエンス振興財団  2016

  • 海馬における経路特異的な情報処理機構の解明

    上原記念生命科学財団  2016

  • 海馬・嗅内皮質の長距離投射GABA作動性神経細胞の領域間相互作用における役割

    金原一郎記念医学医療振興財団  2016

  • 海馬台による投射先特異的な情報処理機構

    ブレインサイエンス振興財団  2016

  • 光遺伝学と多点記録法の融合による神経修飾系の生体内での役割の解明

    東京生化学研究会  2016

  • 自由行動中の動物の脳から細胞外記録される主細胞を投射先によって分類する方法の開発

    島津科学技術振興財団  2016

  • 記憶形成における海馬体神経回路の動作原理

    第一三共生命科学研究振興財団  2015

  • 多点同時記録法と光遺伝学の新規融合による海馬体介在細胞の機能解析

    ホクト生物科学振興財団  2015

  • 海馬体神経回路の動作原理

    住友電工グループ  2015

  • 海馬体介在細胞の生体内機能解析

    アステラス病態代謝研究会  2015

  • 多点同時記録法と光遺伝学を用いた海馬体の細胞種特異的インターニューロンの生体内での機能解析

    持田記念医学薬学振興財団  2015

  • 海馬体の領域間・細胞間の動的相互作用のメカニズム

    内藤記念科学振興財団  2015

▼display all

Other subsidies, etc.

  • 海馬から他の脳領域への情報分配メカニズムの解明

    大阪市立大学  2018.04

  • 海馬の投射先特異的な情報処理機構

    大阪市立大学  2017.04

Outline of education staff

  • Practical training for basic and social medicine
    Basic medical sciences program
    Cell biology
    Neuroscience
    Lab practice: physiology

Charge of on-campus class subject

  • 脳機能系コース

    2018     Undergraduate

  • 細胞生物学コース

    2018     Undergraduate

  • 基礎医学研究推進コース

    2018     Undergraduate

  • 細胞生物学コース

    2022   Weekly class  

Charge of off-campus class subject

  • 生体のしくみ「海馬と記憶」

  • 生体のしくみ「睡眠・覚醒・概日リズムのメカニズム」

Number of papers published by graduate students

  • 2023

    Number of graduate students presentations：1

  • 2022

    Number of graduate students presentations：1

  • 2021

    Number of graduate students presentations：1

  • 2019

    Number of undergraduate student / college student presentations：1  Number of graduate students presentations：2

Social Activities

  • 記憶とナビゲーションの神経メカニズム

    Role(s)： Lecturer

    大阪大学神経科学グループ、NPO法人 脳の世紀推進会議  高校生のための脳科学セミナー  2018.08

    　More details

    Type：Lecture

Media Coverage

  • OUC topics <Researchers> Promotional material

    大阪市立大学広報  大阪市立大学広報誌 vol.21, p.7  2016.05

Job title

  • Job title within the department

    阿倍野医学図書館 

    図書館長  2022.04

  • Job title within the department

    Graduate School of Medicine Department of Medical Science 

    専攻長  2022.04

  • Job title within the department

    Graduate School of Medicine Department of Basic Medical Science 

    専攻長  2022.04

  • Job title within the department

    Graduate School of Medicine Department of Clinical Medical Science 

    専攻長  2022.04