Updated on 2024/04/08

写真a

 
YAMAZAKI Takanori
 
Organization
Graduate School of Medicine Department of Clinical Medical Science Associate Professor
School of Medicine Department of Medical Science
Title
Associate Professor
Affiliation
Institute of Medicine

Position

  • Graduate School of Medicine Department of Clinical Medical Science 

    Associate Professor  2024.04 - Now

  • Graduate School of Medicine Department of Clinical Medical Science 

    Lecturer  2022.04 - 2024.03

  • School of Medicine Department of Medical Science 

    Associate Professor  2024.04 - Now

  • School of Medicine Department of Medical Science 

    Lecturer  2022.04 - 2024.03

Degree

  • 医学博士 （ Osaka City University ）

Research Areas

  • Life Science / Cardiology

  • Life Science / Cardiology

Research Interests

  • cardiology

  • ischemic heart disease

  • peripheral artery disease

  • heart failure

  • Angioscope

  • Intravascular Imaging

  • Optical Coherence Tomography

  • 高血圧

Research subject summary

  • 動脈硬化の病態解析

Research Career

  • 血管内視鏡を用いた病変観察と分子マーカーの測定による、担癌患者の動脈血栓症発症予測因子の探索

    血管内視鏡  Individual

    2019.04 - 2021.03 

  • 大豆イソフラボンによるい血管周囲脂肪組織におけるGPR120の役割

    血管周囲脂肪組織  Individual

    2013.04 - 2014.03 

Professional Memberships

  • 日本心臓病学会

    2021.08 - Now

  • 日本フットケア・足病医学会

      Domestic

  • 日本静脈学会

      Domestic

  • THE JAPANESE SOCIETY OF INTERNAL MEDICINE

      Domestic

  • The Japanese Circulation Society

      Domestic

  • JAPANESE ASSOCIATION OF CARDIOVASCULAR INTERVENTION AND THERAPEUTICS

      Domestic

  • 日本静脈学会

  • 日本フットケア・足病医学会

  • Japan Endovascular Treatment Conference

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Committee Memberships (off-campus)

  • 近畿支部運営委員   日本心血管インターベンション治療学会  

    2023.02 - Now 

  • 近畿支部評議員   日本循環器学会  

    2021.07 - Now 

  • 近畿支部評議員   日本内科学会  

    2021.06 - Now 

  • Faculty   TransーCatheter Imaging Forum  

    2020.05 - Now 

Awards

  • 2022 JVIR EDITOR'S AWARD HONOREE, DISTINGUISHED CLINICAL STUDY

    2023.03   Journal of Vascular and Interventional Radiology   Angioscopic Ulcerated Plaques in the Femoropopliteal Artery Associated with Impaired Infrapopliteal Runoff

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    Country：United States

  • Chairman's Award

    Yamazaki Takanori

    2014.03   Osaka City Medical Association   Tolvaptan Improves Left Ventricular Dysfunction after Myocardial Infarction in Rats

Job Career (off-campus)

  • NPO法人日本血管映像化研究機構   監事

    2023.08 - Now

  • Osaka Metropolitan University   Graduate School of Medicine Department of Cardiovascular Medicine

    2022.04 - Now

  • Osaka City University Graduate School of Medicine   Internal Medicine of Cardiology

    2020.04 - 2022.03

  • Osaka City University Graduate School of Medicine   Internal Medicine of Cardiology

    2019.04 - 2020.03

  • Osaka City University Graduate School of Medicine   Internal Medicine of Cardiology   Lecturer

    2017.04 - 2019.03

  • 公益財団法人　浅香山病院   循環器内科   医員

    2014.04 - 2017.03

  • Asakayama General Hospital   Internal Medicine of Cardiology

    2014.04 - 2017.03

  • Osaka City University Graduate School of Medicine   Internal Medicine of Cardiology   Post Doctoral Fellow

    2012.04 - 2014.03

  • Osaka City University Graduate School of Medicine   Internal Medicine of Cardiology   Graduate Student

    2008.04 - 2012.03

  • 財団法人　浅香山病院   循環器内科   医員

    2007.04 - 2008.03

  • Asakayama General Hospital   Internal Medicine

    2007.04 - 2008.03

  • Asakayama General Hospital   medical resident

    2005.04 - 2007.03

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Education

  • Osaka City University Graduate School of Medicine   Doctor's Course   Graduated/Completed

    2008.04 - 2012.03

  • Osaka City University     Graduated/Completed

    1999.04 - 2005.03

Papers

  • Utility and optimal dose of nicorandil for physiological assessment of the femoropopliteal artery Reviewed

    Naoki Yoshioka, Takenobu Shimada, Yoshihiro Iwasaki, Hisako Yoshida, Kenichiro Otsuka, Takanori Yamazaki, Yasuhiro Morita, Shigeru Nakamura, Daiju Fukuda, Itsuro Morishima

    Catheterization and Cardiovascular Interventions   2024.02（ ISSN:1522-1946 ）

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.1002/ccd.30976

    PubMed

  • Plaque Morphological Changes in Femoropopliteal Arterial Lesions Caused by Balloon Angioplasty: Analysis Through Integrated Backscatter Intravascular Ultrasound Reviewed

    Ou Hayashi, Takenobu Shimada, Naoki Fujisawa, Takanori Yamazaki, Yasuhiro Izumiya, Daiju Fukuda

    European Journal of Vascular and Endovascular Surgery   2024.02（ ISSN:1078-5884 ）

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.ejvs.2024.02.003

    PubMed

  • Tissue responses to everolimus-eluting stents implanted in severely calcified lesions following atherectomy. Reviewed

    Tomohiro Yamaguchi, Takanori Yamazaki, Hisako Yoshida, Kotaro Matsumoto, Ryosuke Yahiro, Kazuhiro Nakao, Yusuke Kure, Tsukasa Okai, Takenobu Shimada, Kenichiro Otsuka, Yasuhiro Izumiya, Daiju Fukuda

    Cardiovascular intervention and therapeutics   39 ( 1 )   34 - 44   2024.01（ ISSN:1868-4300 ）

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    Authorship：Corresponding author   Publishing type：Research paper (scientific journal)   International / domestic magazine：Domestic journal  

    Histopathological examination has revealed that stents on severely calcified plaques were associated with delayed vascular healing. Although atherectomy devices can increase the number of malapposed struts, tissue responses to implanted drug eluting stents in atherectomy patients remain largely unknown. This retrospective observational study included 30 patients who underwent atherectomy and everolimus-eluting stent (EES) deployment for severely calcified coronary lesions (biodegradable polymer EES (BP-EES), n = 15; durable polymer EES (DP-EES), n  = 15). Optical coherence tomography was carried out at baseline and follow-up, and struts with acute stent malapposition (ASM) were categorized as struts on modified calcium (mod-Ca), non-modified calcium (non-mod-Ca), or non-calcium (non-Ca). Adequate vascular healing, defined as ASM resolution with neointimal coverage, was compared between the BP-EES and DP-EES groups. Multivariate linear regression analysis using a generalized estimated equation revealed that BP-EES use was associated with significantly better adequate vascular healing compared with DP-EES (odds ratio [OR]: 3.691, 95% confidence interval [CI] 1.175-11.592, P = 0.025). adequate vascular healing was associated with the underlying plaque morphology (mod-Ca vs non-mod-Ca: OR 2.833, 95% CI 1.491-5.384, P = 0.001; non-Ca vs non-mod-Ca: OR 1.248, 95% CI 0.440-3.543, P = 0.677). This study demonstrates that drug-eluting stent selection and calcium modification are possible factors affecting vascular healing of malapposed struts in severely calcified lesions.

    DOI： 10.1007/s12928-023-00965-4

    PubMed

  • Correction: Tissue responses to everolimus-eluting stents implanted in severely calcified lesions following atherectomy.

    Tomohiro Yamaguchi, Takanori Yamazaki, Hisako Yoshida, Kotaro Matsumoto, Ryosuke Yahiro, Kazuhiro Nakao, Yusuke Kure, Tsukasa Okai, Takenobu Shimada, Kenichiro Otsuka, Yasuhiro Izumiya, Daiju Fukuda

    Cardiovascular intervention and therapeutics   39 ( 1 )   45 - 46   2024.01（ ISSN:1868-4300 ）

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    International / domestic magazine：Domestic journal  

    DOI： 10.1007/s12928-023-00973-4

    PubMed

  • Thrombus or tumor? Reviewed

    Shiho Wakasa, Hiroya Hayashi, Takanori Yamazaki, Yasuhiro Izumiya, Daiju Fukuda

    Clinical case reports   11 ( 10 )   e7975   2023.10（ ISSN:2050-0904 ）

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    Authorship：Corresponding author   Publishing type：Research paper (scientific journal)   International / domestic magazine：International journal  

    KEY CLINICAL MESSAGE: Contrast defects in veins are often diagnosed as benign thrombi, but depending on the patient's background it is necessary to differentiate between tumor thrombi. It is difficult to differentiate between these using contrast-enhanced CT alone, but with angioscopy it is easy to visually distinguish between a benign and tumor thrombi. ABSTRACT: Contrast-enhanced computer tomography (CT) performed on a male patient being treated for de-differentiated chondrosarcoma revealed contrast defects in the pulmonary artery and right femoral vein, and a diagnosis of pulmonary artery thromboembolism and venous thromboembolism was made, and oral anticoagulant therapy was started. However, a follow-up CT showed that the contrast defect had extended to the inferior vena cava. Observation using an angioscope revealed that it was not a benign thrombi but a tumor.

    DOI： 10.1002/ccr3.7975

    PubMed

  • Endoscopic assessment of WATCHMAN 17 months after implantation. Reviewed

    Takanori Yamazaki, Tomotaka Yoshiyama, Asahiro Ito, Yasuhiro Izumiya, Daiju Fukuda

    Cardiovascular intervention and therapeutics   38 ( 2 )   258 - 259   2023.04（ ISSN:18684300 ）

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    Authorship：Lead author,　Corresponding author   Publishing type：Research paper (scientific journal)   International / domestic magazine：Domestic journal  

    DOI： 10.1007/s12928-022-00902-x

    PubMed

  • Quantification of pulmonary perfusion using LSIM-CT correlates with pulmonary hemodynamics in patients with CTEPD. Reviewed

    Tomohiro Yamaguchi, Shoichi Ehara, Hisako Yoshida, Daisuke Himoto, Shinichiro Izuta, Ou Hayashi, Hiroya Hayashi, Mana Ogawa, Atsushi Shibata, Takanori Yamazaki, Yasuhiro Izumiya, Daiju Fukuda

    Frontiers in cardiovascular medicine   10   1237296 - 1237296   2023（ ISSN:2297-055X ）

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    Publishing type：Research paper (scientific journal)   International / domestic magazine：International journal  

    BACKGROUND: Lung subtraction iodine mapping (LSIM)-CT is a clinically useful technique that can visualize pulmonary mal-perfusion in patients with chronic thromboembolic pulmonary disease (CTEPD). However, little is known about the associations of LSIM images with hemodynamic parameters of patients with CTEPD. This study investigates a parameter of LSIM images associated with mean pulmonary arterial pressure (mPAP) and validates the association between pulmonary vascular resistance, right atrial pressure, cardiac index, and exercise capacity in patients with CTEPD. METHODS: This single-center, prospective, observational study involved 30 patients diagnosed with CTEPD using lung perfusion scintigraphy. To examine the correlation of decreased pulmonary perfusion area (DPA) with mPAP, areas with 0-10, 0-15, 0-20, and 0-30 HU in lung subtraction images were adopted in statistical analysis. The DPA to total lung volume ratio (DPA ratio, %) was calculated as the ratio of each DPA volume to the total lung volume. To assess the correlation between DPA ratios of 0-10, 0-15, 0-20, and 0-30 HU and mPAP, Spearman's rank correlation coefficient was used. RESULTS: The DPA ratio of 0-10 HU had the most preferable correlation with mPAP than DPA ratios of 0-15, 0-20, and 0-30 HU (ρ = 0.440, P = 0.015). The DPA ratio of 0-10 HU significantly correlates with pulmonary vascular resistance (ρ = 0.445, P = 0.015). The receiver operating characteristic curve analysis indicated that the best cutoff value of the DPA ratio of 0-10 HU for the prediction of an mPAP of ≥30 mmHg was 8.5% (AUC, 0.773; 95% CI, 0.572-0.974; sensitivity, 83.3%; specificity, 75.0%). Multivariate linear regression analysis, which was adjusted for the main pulmonary arterial to ascending aortic diameter ratio and right ventricular to left ventricular diameter ratio, indicated that the DPA ratio of 0-10 HU was independently and significantly associated with mPAP (B = 89.7; 95% CI, 46.3-133.1, P < 0.001). CONCLUSION: The DPA ratio calculated using LSIM-CT is possibly useful for estimating the hemodynamic status in patients with CTEPD.

    DOI： 10.3389/fcvm.2023.1237296

    PubMed

  • 両心不全で搬送された超高齢慢性血栓塞栓性肺高血圧症の一例

    山口 智大, 泉家 康宏, 林 央, 林 浩也, 柴田 敦, 山崎 貴紀, 福田 大受

    脈管学   62 ( Suppl. )   S174 - S174   2022.10（ ISSN:0387-1126 ）

  • 全身性強皮症に伴う重症間質性肺疾患を合併した肺動脈高血圧症における吸入一酸化窒素を用いた肺血管反応性試験　1症例報告(Vaso reactivity test using inhaled nitric oxide for pulmonary arterial hypertension accompanied by severe interstitial lung disease attributed to systemic sclerosis: A case report)

    Yamaguchi Tomohiro, Izumiya Yasuhiro, Hayashi Ou, Hayashi Hiroya, Ogawa Mana, Shibata Atsushi, Yamazaki Takanori, Yoshiyama Minoru

    Journal of Cardiology Cases   25 ( 3 )   144 - 148   2022.03

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    症例は70歳男性で、安静時の呼吸困難を主訴に来院した。限局皮膚硬化型全身性強皮症に伴う間質性肺炎の既往があった。受診時の血圧は90/61mmHg、心拍数は111bpm、酸素飽和度は84%であった。手指皮膚硬化、頸静脈怒張、両下肢に圧痕性浮腫を認めた。臨床検査で脳性ナトリウム利尿ペプチド(BNP)は289.4pg/mL、抗核抗体は640倍であった。心電図は洞調律で、I、aVL、V4～V6誘導で陰性T波を認めた。高分解能CTで両肺野に著明な線維化を認めたが、疾患の進行は見られなかった。心臓カテーテル検査で平均肺動脈圧(mPAP)は48mmHg、肺血管抵抗(PVR)は9.0 Wood unitであった。酸素流量を2L/分で酸素療法を併用し、一酸化窒素を用いた肺血管反応性試験を行ったところ、mPAPは27mmHg、PVRは5.3W.U、動脈血酸素分圧は129 Torrに改善した。以上の所見から肺血管拡張薬が有効と判断し、タダラフィル(10mg)とイロプロスト吸入剤(5μg)を1日6回投与した。3週間後にPVRは4.2 W.U、BNPは183.7pg/mLに低下した。呼吸困難は改善し、退院に至った。

  • Vaso reactivity test using inhaled nitric oxide for pulmonary arterial hypertension accompanied by severe interstitial lung disease attributed to systemic sclerosis: A case report. Reviewed

    Tomohiro Yamaguchi, Yasuhiro Izumiya, Ou Hayashi, Hiroya Hayashi, Mana Ogawa, Atsushi Shibata, Takanori Yamazaki, Minoru Yoshiyama

    Journal of cardiology cases   25 ( 3 )   144 - 148   2022.03

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    International / domestic magazine：Domestic journal  

    A 70-year-old man with severe interstitial pneumonia attributed to limited cutaneous systemic sclerosis was referred to our institution because of worsening dyspnea. High-resolution computed tomography did not show considerable progression compared with previous images, whereas transthoracic echocardiography showed severe right ventricular dysfunction. Oxygen saturation was decreased to 84% at room air. A blood test showed an increase in the plasma brain natriuretic peptide level (289.4 pg/mL). Right heart catheterization (RHC) showed a remarkably high mean pulmonary arterial pressure (mPAP) of 48 mmHg at room air. A vaso reactivity test using inhaled nitric oxide showed improvement of mPAP, pulmonary vascular resistance (PVR), and partial pressure of arterial oxygen. These findings suggested that the patient responded to pulmonary hypertension (PH)-targeted drugs. We then prescribed tadalafil 10 mg and inhaled iloprost 5 µg six times daily. Three weeks after initiating PH-targeted drugs, RHC indicated hemodynamic improvement similar to hemodynamic changes in the vaso reactivity test (mPAP: 28 mmHg; PVR: 4.2 W.U.). He was discharged with improved symptoms. Inhaled nitric oxide during RHC might be helpful to consider the treatment strategy when patients have PH comorbid systemic sclerosis and severe interstitial lung disease. <Learning objective: In patients with pulmonary hypertension (PH) attributed to systemic sclerosis and interstitial lung disease, determining the indication of vaso dilatory therapies for PH is clinically difficult. A vaso reactivity test using inhaled nitric oxide during right heart catheterization might be useful for identifying patients who will respond to PH-targeted therapy.>.

    DOI： 10.1016/j.jccase.2021.08.003

    PubMed

  • Angioscopic ulcerated plaques in the femoropopliteal artery associated with impaired infrapopliteal runoff. Reviewed

    Tomohiro Yamaguchi, Takanori Yamazaki, Hisako Yoshida, Ou Hayashi, Ryosuke Yahiro, Kazuhiro Nakao, Tsukasa Okai, Shoichi Ehara, Yasuhiro Izumiya, Minoru Yoshiyama

    Journal of vascular and interventional radiology : JVIR   33 ( 2 )   97 - 103.e1   2022.02（ ISSN:1051-0443 ）

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    Authorship：Corresponding author   Publishing type：Research paper (scientific journal)   International / domestic magazine：International journal  

    PURPOSE: The aim of this study was to validate a hypothesis that there is a correlation between up-stream atherosclerosis in femoropopliteal arteries (FPA) assessed by angioscopy and poor angiographic runoff score (ARS). MATERIALS AND METHODS: Thirty-one patients with peripheral arterial disease who underwent endovascular therapy and angioscopy were prospectively included. The yellow plaque color scores were semi-quantitatively determined as 0, 1, 2, or 3. Irregular plaques with rough surfaces, similar to gastric ulcers, were defined as ulcerated plaques (UPs). RESULTS: UPs were detected in 74.2% of enrolled diseased legs by angioscopy. The mural thrombi were more commonly observed in patients with UPs in FPA vs without (91.3% vs 37.5%, respectively; p=0.006), which were frequently on the UPs (21/23 patients with UPs). Univariate and multivariate linear regression analysis revealed that the presence of UPs was positively and independently associated with poor ARS, and that oral anticoagulant use was independently associated with preferable ARS (standardized β= 0.462, p= 0.004, and standardized β= -0.411, p= 0.009, respectively, in the multivariate analysis). CONCLUSIONS: UPs, associated with mural thrombi, were demonstrated to be one of the factors associated with poor ARS according to the angioscopic examinations.

    DOI： 10.1016/j.jvir.2021.10.013

    PubMed

  • Acute pulmonary embolism with high-intensity signals on magnetic resonance direct thrombus imaging Reviewed

    Tomohiro Yamaguchi, Shoichi Ehara, Atsushi Shibata, Takanori Yamazaki, Yasuhiro Izumiya

    European Heart Journal - Cardiovascular Imaging   22 ( 11 )   e159   2021.10（ ISSN:2047-2404 ）

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    Publishing type：Research paper (scientific journal)   International / domestic magazine：International journal  

    DOI： 10.1093/ehjci/jeab123

    PubMed

  • Relationship of high-intensity plaques on T1-weighted magnetic resonance imaging with coronary intraplaque hemorrhage: A directional coronary atherectomy study Reviewed

    Shoichi Ehara, Kazuki Mizutani, Takanori Yamazaki, Kenji Matsumoto, Tsukasa Okai, Tomohiro Yamaguchi, Yasuhiro Izumiya, Takahiko Naruko, Minoru Yoshiyama

    American Heart Journal Plus: Cardiology Research and Practice   10   100047 - 100047   2021.10（ ISSN:2666-6022 ）

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.ahjo.2021.100047

  • Successful treatment for a patient with chronic thromboembolic pulmonary hypertension comorbid with essential thrombocythemia with the JAK2 V617F mutation by balloon pulmonary angioplasty Reviewed

    Yamaguchi Tomohiro, Izumiya Yasuhiro, Hayashi Hiroya, Ichikawa Yoshitaka, Ishikawa Hirotoshi, Shibata Atsushi, Yamazaki Takanori, Yoshiyama Minoru

    RESPIRATORY MEDICINE CASE REPORTS   31   101235 - 101235   2020（ ISSN:2213-0071 ）

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    Publishing type：Research paper (scientific journal)  

    A-71-year-old woman was diagnosed as chronic thromboembolic pulmonary hypertension (CTEPH) accompanied by essential thrombocythemia (ET) with JAK2 V617F mutation. Blood test showed remarkable increase of platelet counts (132.9 × 10^4/μL) and elevated plasma BNP level (125.1pg/mL). Right heart catheterization (RHC) revealed remarkably high mean pulmonary arterial pressure (mPAP) of 43 mmHg. We gave her riociguat of 7.5mg, oral anticoagulants, oxygen inhalation for CTEPH, and anagrelide for ET. We performed 4 sessions of balloon pulmonary angioplasty (BPA) in 9 months RHC revealed successful hemodynamic improvement (mPAP = 21 mmHg) after final BPA procedure without riociguat. At six month later after final BPA procedure, RHC showed steadily improvement of mPAP (21 mmHg) without riociguat and oxygen inhalation. She lives well without oxygen inhalation and PH targeted therapy. This is the first report of successful treatment for a patient with CTEPH comorbid with ET with JAK2 V617F mutation by BPA.

    DOI： 10.1016/j.rmcr.2020.101235

    PubMed

  • Neointimal coverage after second generation drug-eluting stent implantation has a relationship with pre-existing atherosclerotic lesion characteristics Reviewed

    Nomoto Yohta, Nakagawa Masashi, Shirai Nobuyuki, Kajio Keiko, Mizutani Kazuki, Yamazaki Takanori, Sugioka Kenichi, Kamimori Kimio, Ueda Makiko, Izumiya Yasuhiro, Yoshiyama Minoru

    MEDICINE   98 ( 37 )   e17097   2019.09（ ISSN:0025-7974 ）

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.1097/MD.0000000000017097

    PubMed

  • Association between debulking area of rotational atherectomy and platform revolution speed-Frequency domain optical coherence tomography analysis. Reviewed

    Mizutani K, Hara M, Nakao K, Yamaguchi T, Okai T, Nomoto Y, Kajio K, Kaneno Y, Yamazaki T, Ehara S, Kamimori K, Izumiya Y, Yoshiyama M

    Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions   2019.04（ ISSN:1522-1946 ）

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.1002/ccd.28212

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  • Cardioprotective effects of dipeptidyl peptidase-4 (DPP-4) inhibitors independently of DPP-4 Reviewed

    Yamaguchi T., Yasukatsu I., Yamazaki T., Nakamura Y., Shimada K., Yoshiyama M., Iwao H.

    EUROPEAN HEART JOURNAL   36   777 - 777   2015.08（ ISSN:0195-668X ）

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    Publishing type：Research paper (scientific journal)  

  • Percutaneous treatment of carbon dioxide mist attenuates the development of right ventricular dysfunction in monocrotaline-induced pulmonary hypertensive rats Reviewed

    Yamaguchi T., Izumi Y., Yamazaki T., Nakamura Y., Shimada K., Yoshiyama M., Iwao H.

    EUROPEAN HEART JOURNAL   36   784 - 784   2015.08（ ISSN:0195-668X ）

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    Publishing type：Research paper (scientific journal)  

  • ガスミスト生成器を用いた経皮的な二酸化炭素治療はモノクロタリン誘発性肺高血圧症ラットにおいて右室機能障害の進行を抑制する(Percutaneous Carbon Dioxide Treatment Using a Gas Mist Generator Attenuates the Development of Right Ventricular Dysfunction in Monocrotaline-induced Pulmonary Hypertensive Rats) Reviewed

    Yamaguchi Takehiro, Izumi Yasukatsu, Yamazaki Takanori, Nakamura Yasuhiro, Sano Soichi, Shiota Masayuki, Miura Katsuyuki, Iwao Hiroshi, Yoshiyama Minoru

    大阪市医学会　Osaka City Medical Journal   61 ( 1 )   31 - 41   2015.06（ ISSN:0030-6096 ）

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    Publishing type：Research paper (scientific journal)  

  • Percutaneous Carbon Dioxide Treatment Using a Gas Mist Generator Attenuates the Development of Right Ventricular Dysfunction in Monocrotaline-induced Pulmonary Hypertensive Rats. Reviewed

    Yamaguchi T, Izumi Y, Yamazaki T, Nakamura Y, Sano S, Shiota M, Miura K, Iwao H, Yoshiyama M

    Osaka city medical journal   61 ( 1 )   31 - 41   2015.06（ ISSN:0030-6096 ）

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    Publishing type：Research paper (scientific journal)  

    PubMed

  • 経皮二酸化炭素ミスト療法による実験的心筋梗塞の保護効果(Percutaneous carbon dioxide mist treatment has protective effects in experimental myocardial infarction) Reviewed

    Yamaguchi Takehiro, Yamazaki Takanori, Nakamura Yasuhiro, Shiota Masayuki, Shimada Kenei, Miura Katsuyuki, Iwao Hiroshi, Yoshiyama Minoru, Izumi Yasukatsu

    (公社)日本薬理学会　Journal of Pharmacological Sciences   127 ( 4 )   474 - 480   2015.04（ ISSN:1347-8613 ）

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    Publishing type：Research paper (scientific journal)  

    心筋梗塞(MI)後の心不全に対して炭酸ガス(CO2)ミストを反復投与した際の効果を検討した。CO2ミストをドライミスト生産ユニットで生成させ、ラット全体の腋窩以下をポリエチレン袋で覆って密閉した後にCO2ミストを1日30分、7日間充満させた。ラットは未処理(UT)群、CO2ガス前処理(CG)群、CO2ミスト前処理(CM)群の3群に分け、各ラットの冠動脈を結紮してMIを誘起させ、CO2の効果を比較した。その結果、MIに起因する梗塞サイズと酸化ストレスの増加は、CM群がUT群より有意に低く、単球走化性蛋白質1などの炎症関連遺伝子、形質転換増殖因子β1などの線維症関連遺伝子の発現はCM群で有意に抑制されていた。また、CM群はMI後7日目の左室駆出分画率がUT群より有意に良好であり、これらのパラメータはCG群とUT群が類似していた。以上より、CO2ミストはMIの軽減にとって有用であると考えた。

  • Percutaneous carbon dioxide mist treatment has protective effects in experimental myocardial infarction. Reviewed

    Yamaguchi T, Yamazaki T, Nakamura Y, Shiota M, Shimada K, Miura K, Iwao H, Yoshiyama M, Izumi Y

    Journal of pharmacological sciences   127 ( 4 )   474 - 480   2015.04（ ISSN:1347-8613 ）

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.jphs.2015.03.009

    PubMed

  • Repeated remote ischemic conditioning attenuates left ventricular remodeling via exosome-mediated intercellular communication on chronic heart failure after myocardial infarction. Reviewed

    Yamaguchi T, Izumi Y, Nakamura Y, Yamazaki T, Shiota M, Sano S, Tanaka M, Osada-Oka M, Shimada K, Miura K, Yoshiyama M, Iwao H

    International journal of cardiology   178   239 - 246   2015.01（ ISSN:0167-5273 ）

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    DOI： 10.1016/j.ijcard.2014.10.144

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  • ガスミスト発生装置を用いた経皮的炭酸ガス治療は虚血後肢における側副血行を増大させる(Percutaneous Carbon Dioxide Treatment using a Gas Mist Generator Enhances the Collateral Blood Flow in the lschemic Hindlimb) Reviewed

    Izumi Yasukatsu, Yamaguchi Takehiro, Yamazaki Takanori, Yamashita Naoto, Nakamura Yasuhiro, Shiota Masayuki, Tanaka Masako, Sano Soichi, Osada-Oka Mayuko, Shimada Kenei, Wanibuchi Hideki, Miura Katsuyuki, Yoshiyama Minoru, Iwao Hiroshi

    (一社)日本動脈硬化学会　Journal of Atherosclerosis and Thrombosis   22 ( 1 )   38 - 51   2015.01（ ISSN:1340-3478 ）

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    虚血誘発型血管形成マウスモデルを用いて、炭酸ガスミストが血管形成を促進するかどうかを調査した。さらに、炭酸ガスミスト療法が血管新生増殖因子発現を亢進させ、虚血誘発型血行再建を刺激するか確認した。片側虚血後肢マウスを未処理(UT)群、100%炭酸ガス処理(CG)群、O2とN2の混合気体ミスト処理(AM)群、100%炭酸ガスミスト処理(CM)群に分け、ガスミスト発生装置によってガス状薬剤を充填させたポリエチレン袋内にマウス下半身を1日10分間入れた。虚血後肢における血流、血管内皮増殖因子(VEGF)mRNA発現、蛋白質値、リン酸化内皮一酸化窒素合成酵素(eNOS)値を評価した。UT群と比べてCM群の方が虚血導入7日後では血流が高く維持された。28日後の毛細血管密度はUT群よりもCM群で高かった。AM群とCG群はUT群と同様であった。VEGF mRNA発現、蛋白質値、eNOS値はUT群と比較してCM群で増加した。eNOS欠損マウスにCM処理しても血流量が増加しなかったため、炭酸ガスミストによる血行再建刺激作用はeNOSに依存することが示された。経皮的炭酸ガスミスト療法は、虚血誘発型血管形成の治療に有用であることが示された。

  • Percutaneous Carbon Dioxide Treatment using a Gas Mist Generator Enhances the Collateral Blood Flow in the Ischemic Hindlimb Reviewed

    Izumi Yasukatsu, Yamaguchi Takehiro, Yamazaki Takanori, Yamashita Naoto, Nakamura Yasuhiro, Shiota Masayuki, Tanaka Masako, Sano Soichi, Osada-Oka Mayuko, Shimada Kenei, Wanibuchi Hideki, Miura Katsuyuki, Yoshiyama Minoru, Iwao Hiroshi

    JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS   22 ( 1 )   38 - 51   2015（ ISSN:1340-3478 ）

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  • Percutaneous carbon dioxide treatment using a gas mist generator enhances the collateral blood flow in the ischemic hindlimb. Reviewed

    Izumi Y, Yamaguchi T, Yamazaki T, Yamashita N, Nakamura Y, Shiota M, Tanaka M, Sano S, Osada-Oka M, Shimada K, Wanibuchi H, Miura K, Yoshiyama M, Iwao H

    Journal of atherosclerosis and thrombosis   22 ( 1 )   38 - 51   2015（ ISSN:1340-3478 ）

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.5551/jat.23770

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    CiNii Article

  • The Role of Exosomes on Cardiac Hypertrophy Reviewed

    Yamaguchi Takehiro, Izumi Yasukatsu, Yamazaki Takanori, Yoshiyama Minoru

    JOURNAL OF CARDIAC FAILURE   20 ( 10 )   S205 - S205   2014.10（ ISSN:1071-9164 ）

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  • Noninvasive metabolic syndrome model using an extremely small minipig, the microminipig. Reviewed

    Yamaguchi T, Yamazaki T, Kawaguchi H, Tawa M, Nakamura Y, Shiota M, Osada-Oka M, Tanimoto A, Okamura T, Miura K, Iwao H, Yoshiyama M, Izumi Y

    Journal of pharmacological sciences   126 ( 2 )   168 - 171   2014.10（ ISSN:1347-8613 ）

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.1254/jphs.14171SC

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    CiNii Article

  • 超小型ミニブタ、マイクロミニピッグを用いた非侵襲的メタボリックシンドロームモデル(A Noninvasive Metabolic Syndrome Model Using an Extremely Small Minipig, the Microminipig) Reviewed

    Yamaguchi Takehiro, Yamazaki Takanori, Kawaguchi Hiroaki, Tawa Masashi, Nakamura Yasuhiro, Shiota Masayuki, Osada-Oka Mayuko, Tanimoto Akihide, Okamura Tomio, Miura Katsuyuki, Iwao Hiroshi, Yoshiyama Minoru, Izumi Yasukatsu

    (公社)日本薬理学会　Journal of Pharmacological Sciences   126 ( 2 )   168 - 171   2014.10（ ISSN:1347-8613 ）

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    超小型ミニブタを用いて非侵襲的メタボリックシンドローム(MetS)モデルを作成した。雄の3.5および4.5ヵ月齢の超小型ミニブタに高脂肪・高コレステロール食(HFCD)を8週間摂食させてアテローム性動脈硬化症を誘発し、酸化窒素シンターゼ阻害剤、NG-ニトロ-L-アルギニンメチルエステル(L-NAME)を投与した。HFCDは血清中低密度リポ蛋白質濃度を有意に上昇させ、L-NAMEは血圧を上昇させ、心肥大を増大させた。HFCD誘発性大動脈アテローム性硬化症はL-NAMEの投与により促進された。冠動脈の内皮依存的弛緩は、L-NAMEの投与により顕著に抑制された。本モデルはMetSの機序の解明に有用で、新規治療薬の開発に有用と考えられた。

  • Repetitive treatment of percutaneous carbon dioxide mist prevents high fat diet-induced arteriosclerosis in extremely small size minipig Reviewed

    Izumi Y., Yamaguchi T., Kawaguchi H., Tawa M., Yamazaki T., Shiota M., Tanimoto A., Okamura T., Yoshiyama M., Iwao H.

    EUROPEAN HEART JOURNAL   35   1124 - 1124   2014.09（ ISSN:0195-668X ）

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  • Exosome-mediated intercellular communication by repetitive remote ischemic conditioning reduces left ventricular remodeling on chronic heart failure Reviewed

    Yamaguchi T., Izumi Y., Yamazaki T., Nakamura Y., Sano S., Hanatani A., Shimada K., Yoshiyama M.

    EUROPEAN HEART JOURNAL   35   6 - 7   2014.09（ ISSN:0195-668X ）

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  • The strain pattern, and not Sokolow-Lyon electrocardiographic voltage criteria, is independently associated with anatomic left ventricular hypertrophy. Reviewed

    Ehara S, Hasegawa T, Matsumoto K, Otsuka K, Yamazaki T, Iguchi T, Izumi Y, Shimada K, Yoshiyama M

    Heart and vessels   29 ( 5 )   638 - 644   2014.09（ ISSN:0910-8327 ）

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.1007/s00380-013-0408-0

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  • 心電図上のSokolow-Lyon電位基準ではなくストレイン型が解剖学的左室肥大と独立の関係がある(The strain pattern, and not Sokolow-Lyon electrocardiographic voltage criteria, is independently associated with anatomic left ventricular hypertrophy) Reviewed

    Ehara Shoichi, Hasegawa Takao, Matsumoto Kenji, Otsuka Kenichiro, Yamazaki Takanori, Iguchi Tomokazu, Izumi Yasukatsu, Shimada Kenei, Yoshiyama Minoru

    シュプリンガー・ジャパン(株)　Heart and Vessels   29 ( 5 )   638 - 644   2014.09（ ISSN:0910-8327 ）

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    多断面CT画像で左室重量を評価した患者93例を対象とした研究を行った。左室肥大をSokolow-Lyonの基準で判断すると感度57%、特異度67%、陽性適中度37%、陰性適中度82%であったが、ストレイン型の基準で判断すると感度65%、特異度87%、陽性適中度63%、陰性的中度88%であった。多変量解析によるとストレイン型は左室肥大と関連があったがSokolow-Lyon基準は関連がなかった。

  • Lipid synthesis is promoted by hypoxic adipocyte-derived exosomes in 3T3-L1 cells. Reviewed

    Sano S, Izumi Y, Yamaguchi T, Yamazaki T, Tanaka M, Shiota M, Osada-Oka M, Nakamura Y, Wei M, Wanibuchi H, Iwao H, Yoshiyama M

    Biochemical and biophysical research communications   445 ( 2 )   327 - 333   2014.03（ ISSN:0006-291X ）

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.bbrc.2014.01.183

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  • Insulin resistance is associated with coronary plaque vulnerability: insight from optical coherence tomography analysis. Reviewed

    Iguchi T, Hasegawa T, Otsuka K, Matsumoto K, Yamazaki T, Nishimura S, Nakata S, Ehara S, Kataoka T, Shimada K, Yoshiyama M

    European heart journal cardiovascular Imaging   15 ( 3 )   284 - 291   2014.03（ ISSN:2047-2404 ）

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.1093/ehjci/jet158

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  • Beneficial Effects of Repeated Remote Ischemic Conditioning on Chronic Heart Failure at Chronic Phase After Myocardial Infarction Reviewed

    Yamaguchi Takehiro, Izumi Yasukatsu, Yamazaki Takanori, Nakamura Yasuhiro, Sano Soichi, Hanatani Akihisa, Shimada Kenei, Iwao Hiroshi, Yoshiyama Minoru

    CIRCULATION   128 ( 22 )   2013.11（ ISSN:0009-7322 ）

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  • Intraluminal and Intrawall Hyperintense Plaques Identified by Noncontrast T1-Weighted Magnetic Resonance Imaging Showed Different Vulnerable Plaque Morphology Assessed by Optical Coherence Tomography Reviewed

    Matsumoto Kenji, Ehara Shoichi, Hasegawa Takao, Sakaguchi Mikumo, Inanami Hitoshi, Otsuka Kenichiro, Yamazaki Takanori, Iguchi Tomokazu, Shimada Kenei, Yoshiyama Minoru

    CIRCULATION   128 ( 22 )   2013.11（ ISSN:0009-7322 ）

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  • Repeated Remote Ischemic Conditioning Inhibits Cardiac Remodeling with Chronic Heart Failure after Myocardial Infarction in Rats Reviewed

    Yamaguchi Takehiro, Izumi Yasukatsu, Yamazaki Takanori, Nakamura Yasuhiro, Hanatani Akihisa, Shimada Kenei, Yoshiyama Minoru

    JOURNAL OF CARDIAC FAILURE   19 ( 10 )   S137 - S137   2013.10（ ISSN:1071-9164 ）

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  • Tolvaptan Attenuates Left Ventricular Fibrosis Afer Acute Myocardial Infarction in Rats Reviewed

    Yamazaki Takanori, Nakamura Yasuhiro, Shiota Masayuki, Osada-Oka Mayuko, Fujiki Hiroyuki, Hanataani Akihisa, Shimada kenei, Miura Katsuyuki, Yoshiyama Minoru, Iwao Hiroshi, Izumi Yasukatsu

    The Japanese Pharmacological Society, Journal of Pharmacological Sciences   123 ( 1 )   58 - 66   2013.09（ ISSN:1347-8613 ）

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    Tolvaptan, a non-peptide V<sub>2</sub>-receptor antagonist, is a newly developed diuretic agent. Recently, we reported that tolvaptan has diuretic as well as anti-inflammatory and anti-fibrotic actions in chronic heart failure. In this study, we investigated whether tolvaptan has a cardioprotective effect in acute heart failure after myocardial infarction (MI). After MI induction, rats were randomized into 6 groups as follows: vehicle group, group treated with 15 mg∙kg<sup>−1</sup>∙day<sup>−1</sup> furosemide, 2 groups treated with 3 or 10 mg∙kg<sup>−1</sup>∙day<sup>−1</sup> tolvaptan, and 2 groups treated with 15 mg∙kg<sup>−1</sup>∙day<sup>−1</sup> furosemide combined with 3 or 10 mg∙kg<sup>−1</sup>∙day<sup>−1</sup> tolvaptan. Each agent was administered for 2 weeks, and blood pressure levels and infarct sizes were similar in all MI groups. Lower left ventricular end-systolic volumes and greater improvement of left ventricular ejection fraction were observed in the tolvaptan-treated groups compared with the vehicle group. In contrast, furosemide alone did not improve them. Sirius red staining revealed that tolvaptan significantly repressed MI-induced interstitial fibrosis in the left ventricle. MI-induced mRNA expressions related to cardiac load, inflammation, and fibrosis were significantly attenuated in the combination group. The combination treatment also repressed MI-induced mineralocorticoid receptor expression. Tolvaptan, or combination of furosemide and tolvaptan, may improve cardiac function in acute MI.

    DOI： 10.1254/jphs.13086FP

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  • トルバプタンはラットにおいて心筋梗塞後の左心室線維症を軽減する(Tolvaptan Attenuates Left Ventricular Fibrosis After Acute Myocardial Infarction in Rats) Reviewed

    Yamazaki Takanori, Nakamura Yasuhiro, Shiota Masayuki, Osada-Oka Mayuko, Fujiki Hiroyuki, Hanatani Akihisa, Shimada Kenei, Miura Katsuyuki, Yoshiyama Minoru, Iwao Hiroshi, Izumi Yasukatsu

    (公社)日本薬理学会　Journal of Pharmacological Sciences   123 ( 1 )   58 - 66   2013.09（ ISSN:1347-8613 ）

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    心筋梗塞(MI)後の急性心不全において、利尿薬のトルバプタン(TOL)の心臓保護作用について検討した。MI誘発後、ラットを6群に分け、賦形薬、フロセミド(FUR)15mg/kg/日、TOL 3mg/kg/日、TOL 10mg/kg/日、FUR+TOL 3mg/kg/日、FUR+TOL 10mg/kg/日を2週間投与した。賦形薬群と比較してTOL群では、左室収縮末期容量が低下し、左室駆出分画が改善した。FUR単独では改善作用を示さなかった。TOLは左室のMI誘発性間質線維症を有意に抑制した。MI誘発性mRNA発現は併用群で有意に低下した。併用群ではMI誘発性ミネラルコルチコイド受容体の発現を抑制した。TOLあるいはTOL+FURは急性MIにおける心機能を改善すると考えられた。

  • A case of a lesion containing an intracoronary thrombus detected as hyperintense plaque on T1-weighted cardiovascular magnetic resonance in a patient with silent myocardial ischemia. Reviewed

    Matsumoto K, Ehara S, Hasegawa T, Otsuka K, Yamazaki T, Iguchi T, Shimada K, Yoshiyama M

    Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance   15   50   2013.06（ ISSN:1097-6647 ）

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    DOI： 10.1186/1532-429X-15-50

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  • Vasopressin V2 Receptor Antagonist Tolvaptan Prevents The Development of Chronic Heart Failure via Its Anti-inflammatory and Anti-fibrotic Actions Reviewed

    Yamazaki Takanori, Izumi Yasukatsu, Nakamura Yasuhiro, Yamaguchi Takehiro, Hanatani Akihisa, Shimada Kenei, Iwao Hiroshi, Yoshiyama Minoru

    CIRCULATION   126 ( 21 )   2012.11（ ISSN:0009-7322 ）

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  • Percutaneous Carbon Dioxide Treatment Using a Gas Mist Generator Accelerates Angiogenesis in the Ischemic Hindlimb Reviewed

    Izumi Yasukatsu, Yamazaki Takanori, Nakamura Yasuhiro, Yamaguchi Takehiro, Hanatani Akihisa, Shimada Kenei, Yoshiyama Minoru, Iwao Hiroshi

    CIRCULATION   126 ( 21 )   2012.11（ ISSN:0009-7322 ）

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  • Percutaneous Carbon Dioxide Gas Mist Treatment Improves Cardiac Function after Myocardial Infarction in Rats via Nitric Oxide Activity Reviewed

    Yamazaki Takanori, Izumi Yasukatsu, Nakamura Yasuhiro, Yamaguchi Takehiro, Hanatani Akihisa, Shimada Kenei, Iwao Hiroshi, Yoshiyama Minoru

    CIRCULATION   126 ( 21 )   2012.11（ ISSN:0009-7322 ）

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  • Tolvaptan improves left ventricular dysfunction after myocardial infarction in rats. Reviewed

    Yamazaki T, Izumi Y, Nakamura Y, Yamashita N, Fujiki H, Osada-Oka M, Shiota M, Hanatani A, Shimada K, Iwao H, Yoshiyama M

    Circulation. Heart failure   5 ( 6 )   794 - 802   2012.11（ ISSN:1941-3289 ）

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    DOI： 10.1161/CIRCHEARTFAILURE.112.968750

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  • The Efficacy of Tolvaptan on Renal Function under Reduced Loop Diuretics in Patients with Congestive Heart Failure Reviewed

    Hanatani Akihisa, Yamazaki Takanori, Sugioka Kenichi, Ehara Shoichi, Nakamura Yasuhiro, Izumi Yasukatsu, Takemoto Yasuhiko, Takagi Masahiko, Shimada Kenei, Yoshiyama Minoru

    JOURNAL OF CARDIAC FAILURE   18 ( 10 )   S156 - S156   2012.10（ ISSN:1071-9164 ）

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  • Increased angiogenesis and improved left ventricular function after transplantation of myoblasts lacking the MyoD gene into infarcted myocardium. Reviewed

    Nakamura Y, Asakura Y, Piras BA, Hirai H, Tastad CT, Verma M, Christ AJ, Zhang J, Yamazaki T, Yoshiyama M, Asakura A

    PloS one   7 ( 7 )   e41736   2012.07（ ISSN:1932-6203 ）

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.1371/journal.pone.0041736

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  • Novel device that produces carbon dioxide mist for myocardial infarction treatment in rats. Reviewed

    Yamazaki T, Izumi Y, Nakamura Y, Hanatani A, Shimada K, Muro T, Shiota M, Iwao H, Yoshiyama M

    Circulation journal : official journal of the Japanese Circulation Society   76 ( 5 )   1203 - 1212   2012.05（ ISSN:1346-9843 ）

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.1253/circj.CJ-11-1116

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  • 二酸化炭素霧を発生する新装置によるラットの心筋梗塞治療(Novel Device That Produces Carbon Dioxide Mist for Myocardial Infarction Treatment in Rats) Reviewed

    Yamazaki Takanori, Izumi Yasukatsu, Nakamura Yasuhiro, Hanatani Akihisa, Shimada Kenei, Muro Takashi, Shiota Masayuki, Iwao Hiroshi, Yoshiyama Minoru

    (一社)日本循環器学会　Circulation Journal   76 ( 5 )   1203 - 1212   2012.04（ ISSN:1346-9843 ）

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    二酸化炭素(CO2)浴は各種疾患の治療に利用されているが高濃度のCO2を含む人工浴を作ることは困難である。本研究は高濃度のCO2粒子であるCO2霧を発生する装置を考案し、ラット心筋梗塞に対する治療効果を検討した。左冠動脈を結紮してラットの心筋梗塞を作成し、CO2霧(n=9)、CO2ガス(n=8)を毎日30分間経皮的に投与し、無処置(n=9)ラットと比較した。CO2霧投与群はCO2ガス投与群と比較して組織中の酸化ヘモグロビンと組織中の酸素飽和度が増加した。4週後にはCO2霧投与群は無処置群と比較して心エコー法による駆出率が有意に増加した。以上、CO2霧は心筋梗塞による心不全の治療に有用と思われた。

  • The antifibrotic agent pirfenidone inhibits angiotensin II-induced cardiac hypertrophy in mice Reviewed

    YAMAZAKI Takanori, YAMASHITA Naoto, IZUMI Yasukatsu, NAKAMURA Yasuhiro, SHIOTA Masayuki, HANATANI Akihisa, SHIMADA Kenei, MURO Takashi, IWAO Hiroshi, YOSHIYAMA Minoru

    Hypertension research : clinical and experimental : official journal of the Japanese Society of Hypertension   35 ( 1 )   34 - 40   2012.01（ ISSN:09169636 ）

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  • 抗線維症薬ピルフェニドンはマウスにおけるアンジオテンシンII誘発性心肥大を阻害する(The antifibrotic agent pirfenidone inhibits angiotensin II-induced cardiac hypertrophy in mice) Reviewed

    Yamazaki Takanori, Yamashita Naoto, Izumi Yasukatsu, Nakamura Yasuhiro, Shiota Masayuki, Hanatani Akihisa, Shimada Kenei, Muro Takashi, Iwao Hiroshi, Yoshiyama Minoru

    Nature Publishing Group　Hypertension Research   35 ( 1 )   34 - 40   2012.01（ ISSN:0916-9636 ）

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    アンジオテンシン(Ang)II誘発性心肥大マウスにおけるピルフェニドン(PFD)の予防効果について検討した。マウスを3群に分け、生理食塩水(対照)、AngII、AngII+PFDを2週間投与した。PFDはAngIIを注入中、強制経口投与した。AngII群の血圧は対照群よりも有意に高かった。AngII群とPFD群間で血圧に有意差は見られなかったが、心重量はPFD群で有意に減少した。心エコーでは、AngII群で左室肥大の増加が見られたが、PFDはこれを抑制した。AngIIの連続注入はANP、BNP、TGFβ1のmRNA発現を増加させ、PFDはこれらの増加を阻止した。ミネラルコルチコイド受容体の発現はPFDにより抑制された。PFDは高血圧誘発性心肥大の治療に有効な抗線維症薬である。

  • The antifibrotic agent pirfenidone inhibits angiotensin II-induced cardiac hypertrophy in mice Reviewed

    Yamazaki Takanori, Yamashita Naoto, Izumi Yasukatsu, Nakamura Yasuhiro, Shiota Masayuki, Hanatani Akihisa, Shimada Kenei, Muro Takashi, Iwao Hiroshi, Yoshiyama Minoru

    HYPERTENSION RESEARCH   35 ( 1 )   34 - 40   2012.01（ ISSN:0916-9636 ）

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    DOI： 10.1038/hr.2011.139

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  • Vasopressin V2 Receptor Antagonist Inhibits Cardiac Remodeling with Old Myocardial Infarction in Rats Reviewed

    Yamazaki Takanori, Nakamura Yasuhiro, Izumi Yasukatsu, Hanatani Akihisa, Muro Takashi, Yoshiyama Minoru

    JOURNAL OF CARDIAC FAILURE   17 ( 9 )   S149 - S150   2011.09（ ISSN:1071-9164 ）

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  • Percutaneous carbon dioxide gas mist ameliorates cardiac remodeling after myocardial infarction in rats Reviewed

    Yamazaki T., Nakamura Y., Izumi Y., Hanatani A., Shimada K., Muro T., Yoshiyama M.

    EUROPEAN HEART JOURNAL   32   291 - 292   2011.08（ ISSN:0195-668X ）

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  • Cushing's Syndrome by Left Adrenocortical Adenoma Synchronously Associated with Primary Aldosteronism by Right Adrenocortical Adenoma : Report of a Case Reviewed

    ONODA NAOYOSHI, ISHIKAWA TETSURO, NISHIO KOHEI, TAHARA HIDEKI, INABA MASAAKI, WAKASA KENICHI, SUMI TOMOHIKO, YAMAZAKI TAKANORI, SHIGEMATU KAZUTO, HIRAKAWA KOSEI

    Endocrine journal   56 ( 3 )   495 - 502   2009.06（ ISSN:09188959 ）

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    CiNii Article

  • Cushing's Syndrome by Left Adrenocortical Adenoma Synchronously Associated with Primary Aldosteronism by Right Adrenocortical Adenoma: Report of a Case Reviewed

    Onoda Naoyoshi, Ishikawa Tetsuro, Nishio Kohei, Tahara Hideki, Inaba Masaaki, Wakasa Kenichi, Sumi Tomohiko, Yamazaki Takanori, Shigematu Kazuto, Hirakawa Kosei

    ENDOCRINE JOURNAL   56 ( 3 )   495 - 502   2009.06（ ISSN:0918-8959 ）

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  • Cushing's syndrome by left adrenocortical adenoma synchronously associated with primary aldosteronism by right adrenocortical adenoma: report of a case. Reviewed

    Onoda N, Ishikawa T, Nishio K, Tahara H, Inaba M, Wakasa K, Sumi T, Yamazaki T, Shigematsu K, Hirakawa K

    Endocrine journal   56 ( 3 )   495 - 502   2009（ ISSN:0918-8959 ）

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.1507/endocrj.k08e-268

    PubMed

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Books and Other Publications

  • NOGA血流維持型汎用血管内視鏡ガイドブック

    児玉 和久, 小松 誠, 由谷 親夫, 樋口 義治, 上田 泰敬, 木村 茂樹, 臺 和興, 塩出 宣雄, 市川 稔, 川上 秀生, 高山 忠輝, 小嶋 啓介, 片野 雄大, 木村 和美, 持田 泰寛, 小林 修三, 山崎 貴紀, 高橋 覚, 安永 元樹, 松岡 宏, 廣 高史, 安達 賢太郎, 濱中 佑馬, 伊苅 裕二, 中渡瀬 智, 大原 知樹, 深町 大介, 西 宏之, 村上 貴志, 小泉 淳（ Role： Joint author ,  Ⅰ 総論 C 大動脈 25 「下肢の治療に血管内視鏡がどう役立ちますか？」、Ⅲ 手技 C 大動脈 16「EVTの際に行うシステムは、血管内視鏡にどう活用できますか？」）

    株式会社 中山書店  2022.04  （ ISBN:9784521749365 ）

MISC

  • 血管内視鏡により静脈内血栓と鑑別した静脈内腫瘍浸潤の一例

    林 浩也, 若狭 志保, 山崎 貴紀, 泉家 康宏, 福田 大受

    静脈学   34 ( 2 )   266 - 266   2023.06（ ISSN:0915-7395 ） （ eISSN:2186-5523 ）

  • 移植後17ヵ月のWATCHMANの内視鏡評価(Endoscopic assessment of WATCHMAN 17 months after implantation)

    Yamazaki Takanori, Yoshiyama Tomotaka, Ito Asahiro, Izumiya Yasuhiro, Fukuda Daiju

    Cardiovascular Intervention and Therapeutics   38 ( 2 )   258 - 259   2023.04（ ISSN:1868-4300 ）

  • 高血圧診療におけるARNIへの期待~ARBからARNIへ~

    山崎貴紀, 工藤新三, 泉家康宏, 福田大受

    日本心臓病学会学術集会(Web)   71st   2023

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  • 血管内視鏡により静脈内血栓と鑑別した静脈内腫瘍浸潤の一例

    林浩也, 若狭志保, 山崎貴紀, 泉家康宏, 福田大受

    静脈学(Web)   34 ( 2 )   2023（ ISSN:2186-5523 ）

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  • 両心不全で搬送された超高齢慢性血栓塞栓性肺高血圧症の一例

    山口智大, 泉家康宏, 林央, 林浩也, 柴田敦, 山崎貴紀, 福田大受

    脈管学(Web)   62 ( supplement )   2022（ ISSN:1880-8840 ）

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  • 両上肢深部静脈血栓症をきっかけに肺癌が疑われるも早期診断に至らなかった一例

    林浩也, 辻明宏, 山崎貴紀, 泉家康宏, 葭山稔

    静脈学(Web)   32 ( 2 )   2021（ ISSN:2186-5523 ）

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  • 当院における慢性血栓塞栓性肺高血圧症診療の取り組み

    山口智大, 泉家康宏, 林央, 林浩也, 小川真奈, 柴田敦, 山崎貴紀, 葭山稔

    日本循環制御医学会総会・学術集会プログラム・抄録集   42nd   2021

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  • Stent fractureによる度重なる再狭窄に対して、OCTガイド下のRotablatorが有効であった一例 Reviewed

    藤原 良亮, 岡井 主, 八尋 亮介, 山口 智大, 梶尾 啓子, 山崎 貴紀, 紙森 公雄, 水谷 一輝, 泉家 康宏, 葭山 稔

    (一社)日本心血管インターベンション治療学会　日本心血管インターベンション治療学会抄録集   28回   [MO116 - 001]   2019.09

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  • 肺高血圧症の難渋症例から学ぶ診療のキーポイント 免疫抑制療法の選択と調整に難渋した全身性エリテマトーデスに伴う重症肺高血圧症の一例 Reviewed

    山口 智大, 泉家 康宏, 石川 裕敏, 柴田 敦, 山崎 貴紀, 葭山 稔

    (一社)日本心臓病学会, 日本心臓病学会学術集会抄録   67回   S - C1   2019.09

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  • 肺高血圧症の難渋症例から学ぶ診療のキーポイント 免疫抑制療法の選択と調整に難渋した全身性エリテマトーデスに伴う重症肺高血圧症の一例 Reviewed

    山口 智大, 泉家 康宏, 石川 裕敏, 柴田 敦, 山崎 貴紀, 葭山 稔

    (一社)日本心臓病学会　日本心臓病学会学術集会抄録   67回   S - 3   2019.09

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  • 十分な血栓吸引後にRotablatorを施行したSTEMIの一例 Reviewed

    吉村 隆太郎, 八尋 亮介, 山口 智大, 岡井 主, 梶尾 啓子, 山崎 貴紀, 江原 省一, 紙森 公雄, 水谷 一輝, 泉家 康宏, 葭山 稔

    (一社)日本心血管インターベンション治療学会　日本心血管インターベンション治療学会抄録集   28回   [MO55 - 004]   2019.09

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  • Left Ventricular Outpouchingを有する重症大動脈弁狭窄症に対して経カテーテル的大動脈弁植え込み術を施行し得た2症例 Reviewed

    梶尾 啓子, 水谷 一輝, 中尾 真奈, 岡井 主, 野元 陽太, 伊藤 朝広, 山崎 貴紀, 岩田 真一, 紙森 公雄, 葭山 稔

    (一社)日本心血管インターベンション治療学会, 日本心血管インターベンション治療学会抄録集   27回   MO428 - MO428   2018.08

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  • 短期間でのcalcified noduleの急激な増悪により不安定狭心症を起こした一症例 Reviewed

    野元 陽太, 岡井 主, 梶尾 啓子, 水谷 一輝, 山崎 貴紀, 紙森 公雄, 葭山 稔

    (一社)日本心血管インターベンション治療学会, 日本心血管インターベンション治療学会抄録集   27回   MO471 - MO471   2018.08

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  • ローターブレーター後の、カッティングバルーンの頻回拡張の有効性と安全性について Reviewed

    山口 智大, 水谷 一輝, 岡井 主, 梶尾 啓子, 野元 陽太, 山崎 貴紀, 江原 省一, 紙森 公雄, 葭山 稔

    (一社)日本心血管インターベンション治療学会, 日本心血管インターベンション治療学会抄録集   27回   MO245 - MO245   2018.08

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  • IVUSでの鑑別に苦慮した血栓性病変に対して,ステントレス治療が有効であった急性心筋梗塞の一例

    吉村隆太郎, 山口智大, 水谷一輝, 岡井主, 梶尾啓子, 野元陽太, 山崎貴紀, 江原省一, 紙森公雄, 泉家康宏, 葭山稔

    日本循環器学会近畿地方会(Web)   126th   2018

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  • 光干渉断層法で脂質プラークが疑われたが,病理診断では多量のマクロファージを認めた方向性粥腫切除施行例

    山口智大, 水谷一輝, 岡井主, 梶尾啓子, 野元陽太, 山崎貴紀, 江原省一, 紙森公雄, 成子隆彦, 葭山稔

    日本循環器学会近畿地方会(Web)   125th   2018

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  • 第二世代薬剤溶出性ステント留置後の新生内膜厚と既存動脈硬化病変の性状との関係について 光干渉断層撮影法での検討 Reviewed

    野元 陽太, 仲川 将志, 岡井 主, 梶尾 啓子, 水谷 一輝, 山崎 貴紀, 白井 伸幸, 紙森 公雄, 上田 真喜子, 葭山 稔

    (一社)日本心臓病学会, 日本心臓病学会学術集会抄録   65回   P - 483   2017.09

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  • 急性期及び慢性期のIVUS/OFDI評価により良好な治療過程を確認し得た特発性冠動脈解離の一例 Reviewed

    野元 陽太, 水谷 一輝, 岡井 主, 梶尾 啓子, 山崎 貴紀, 紙森 公雄, 葭山 稔

    (一社)日本心血管インターベンション治療学会, 日本心血管インターベンション治療学会抄録集   26回   YI2 - 9   2017.07

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  • PDA先行治療で心不全症状が改善したASの一例 Reviewed

    梶尾啓子, 水谷一輝, 中尾真奈, 岡井主, 野元陽太, 伊藤朝広, 山崎貴紀, 岩田真一, 紙森公雄, 葭山稔

    日本循環器学会近畿地方会(Web)   124th   KINKI124,G01 (WEB ONLY)   2017

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    J-GLOBAL

  • Calcified noduleが原因と考えられた冠動脈バイパス後の急性冠症候群の一例

    野元陽太, 水谷一輝, 岡井主, 梶尾啓子, 山崎貴紀, 紙森公雄, 葭山稔

    日本循環器学会近畿地方会(Web)   124th   2017

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  • 肺高血圧による右室モデリングに対する炭酸ガスミストの有効性 Reviewed

    泉 康雄, 山崎 貴紀, 中村 泰浩, 岩尾 洋

    (NPO)日本高血圧学会, 日本高血圧学会総会プログラム・抄録集   38回   456 - 456   2015.10

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  • 広範囲に水疱、びらんを認め、中毒性表皮壊死症(TEN)と考えた1例 Reviewed

    松村 泰宏, 上間 優香, 大霜 智子, 山崎 貴紀, 寺前 彩子, 鶴田 大輔

    日本皮膚科学会-大阪地方会・京滋地方会, 皮膚の科学   14 ( 4 )   188 - 189   2015.08（ ISSN:1347-1813 ）

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  • The Role of Exosomes on Cardiac Hypertrophy Reviewed

    Takehiro Yamaguchi, Yasukatsu Izumi, Takanori Yamazaki, Minoru Yoshiyama

    CHURCHILL LIVINGSTONE INC MEDICAL PUBLISHERS　JOURNAL OF CARDIAC FAILURE   20 ( 10 )   S205 - S205   2014.10（ ISSN:1071-9164 ）

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  • 超小型ミニブタを用いたメタボリック症候群モデル作製 Reviewed

    泉 康雄, 山崎 貴紀, 中村 泰浩, 島田 健永, 葭山 稔, 岩尾 洋

    (NPO)日本高血圧学会, 日本高血圧学会総会プログラム・抄録集   37回   399 - 399   2014.10

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  • 冠動脈完全閉塞病変においてWhole Heart Coronary T1強調Black Blood MRIで描出される閉塞区間体部の高信号の有無は閉塞期間と相関する Reviewed

    松本 健嗣, 江原 省一, 長谷川 隆生, 坂口 海雲, 稲波 整, 大塚 憲一郎, 山崎 貴紀, 仲川 将志, 島田 健永, 葭山 稔

    (一社)日本心臓病学会, 日本心臓病学会学術集会抄録   62回   O - 261   2014.09

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  • 慢性心不全に対する一過性四肢虚血コンディショニング効果 Reviewed

    山口 雄大, 泉 康雄, 山崎 貴紀, 中村 泰浩, 岡 真優子, 塩田 正之, 葭山 稔, 岩尾 洋

    日本心脈管作動物質学会, 血管   37 ( 1 )   29 - 29   2014.01（ ISSN:0911-4637 ）

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  • 急性心筋炎を繰り返した一例

    石川世良, 橋本麻友, 豊島範子, 山崎貴紀, 小川景太郎, 織田茂哉, 泉谷悟, 大村崇, 田原旭

    日本循環器学会近畿地方会(Web)   118th   2014

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  • トルバプタンはラットにおける心筋梗塞後の左室機能障害を改善させる Reviewed

    山崎 貴紀, 泉 康雄, 中村 泰浩, 山下 直人, 藤木 浩之, 岡 真優子, 塩田 正之, 花谷 彰久, 島田 健永, 岩尾 洋, 葭山 稔

    大阪市医学会, 大阪市医学会雑誌   62   38 - 39   2013.12（ ISSN:0386-4103 ）

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  • Beneficial Effects of Repeated Remote Ischemic Conditioning on Chronic Heart Failure at Chronic Phase After Myocardial Infarction Reviewed

    Takehiro Yamaguchi, Yasukatsu Izumi, Takanori Yamazaki, Yasuhiro Nakamura, Soichi Sano, Akihisa Hanatani, Kenei Shimada, Hiroshi Iwao, Minoru Yoshiyama

    LIPPINCOTT WILLIAMS & WILKINS　CIRCULATION   128 ( 22 )   2013.11（ ISSN:0009-7322 ）

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  • Intraluminal and Intrawall Hyperintense Plaques Identified by Noncontrast T1-Weighted Magnetic Resonance Imaging Showed Different Vulnerable Plaque Morphology Assessed by Optical Coherence Tomography Reviewed

    Kenji Matsumoto, Shoichi Ehara, Takao Hasegawa, Mikumo Sakaguchi, Hitoshi Inanami, Kenichiro Otsuka, Takanori Yamazaki, Tomokazu Iguchi, Kenei Shimada, Minoru Yoshiyama

    LIPPINCOTT WILLIAMS & WILKINS　CIRCULATION   128 ( 22 )   2013.11（ ISSN:0009-7322 ）

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  • Repeated Remote Ischemic Conditioning Inhibits Cardiac Remodeling with Chronic Heart Failure after Myocardial Infarction in Rats Reviewed

    Takehiro Yamaguchi, Yasukatsu Izumi, Takanori Yamazaki, Yasuhiro Nakamura, Akihisa Hanatani, Kenei Shimada, Minoru Yoshiyama

    CHURCHILL LIVINGSTONE INC MEDICAL PUBLISHERS　JOURNAL OF CARDIAC FAILURE   19 ( 10 )   S137 - S137   2013.10（ ISSN:1071-9164 ）

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  • Whole Heart Coronary T1-weighted Black Blood MRIで描出される冠動脈プラーク高信号の局在に関する検討 OCT所見との比較検討 Reviewed

    松本 健嗣, 江原 省一, 長谷川 隆生, 坂口 海雲, 稲波 整, 大塚 憲一郎, 山崎 貴紀, 井口 朋和, 島田 健永, 葭山 稔

    (一社)日本心臓病学会, 日本心臓病学会誌   8 ( Suppl.I )   302 - 302   2013.09（ ISSN:1882-4501 ）

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  • 電子顕微鏡を用いた薬剤溶出性ステントのポリマー耐久性の検討 Reviewed

    井口 朋和, 長谷川 隆生, 坂口 海雲, 松本 健嗣, 大塚 憲一郎, 山崎 貴紀, 西村 哲, 江原 省一, 島田 健永, 葭山 稔

    (一社)日本心臓病学会, 日本心臓病学会誌   8 ( Suppl.I )   524 - 524   2013.09（ ISSN:1882-4501 ）

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  • マルチスライスCTを用いた全冠動脈枝における石灰化の分布に関する検討 Reviewed

    江原 省一, 松本 健嗣, 長谷川 隆生, 井口 朋和, 山崎 貴紀, 大塚 憲一郎, 稲波 整, 坂口 海雲, 島田 健永, 葭山 稔

    (一社)日本心臓病学会, 日本心臓病学会誌   8 ( Suppl.I )   529 - 529   2013.09（ ISSN:1882-4501 ）

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  • ラット心筋梗塞急性期および慢性期に対するバソプレシンV2受容体拮抗薬の有効性 Reviewed

    泉 康雄, 山崎 貴紀, 岡 真優子, 塩田 正之, 岩尾 洋

    日本心脈管作動物質学会, 血管   36 ( 1 )   32 - 32   2013.01（ ISSN:0911-4637 ）

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  • 超小型ミニブタを用いた,非侵襲的メタボリック症候群モデルの作製

    泉康雄, 川口博明, 田和正志, 山崎貴紀, 山口雄大, 岡真優子, 塩田正之, 葭山稔, 谷本昭英, 岡村富夫, 岩尾洋

    高血圧関連疾患モデル学会学術総会抄録集   49th   2013

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  • Percutaneous Carbon Dioxide Gas Mist Treatment Improves Cardiac Function after Myocardial Infarction in Rats via Nitric Oxide Activity Reviewed

    Takanori Yamazaki, Yasukatsu Izumi, Yasuhiro Nakamura, Takehiro Yamaguchi, Akihisa Hanatani, Kenei Shimada, Hiroshi Iwao, Minoru Yoshiyama

    LIPPINCOTT WILLIAMS & WILKINS　CIRCULATION   126 ( 21 )   2012.11（ ISSN:0009-7322 ）

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  • Vasopressin V2 Receptor Antagonist Tolvaptan Prevents The Development of Chronic Heart Failure via Its Anti-inflammatory and Anti-fibrotic Actions Reviewed

    Takanori Yamazaki, Yasukatsu Izumi, Yasuhiro Nakamura, Takehiro Yamaguchi, Akihisa Hanatani, Kenei Shimada, Hiroshi Iwao, Minoru Yoshiyama

    LIPPINCOTT WILLIAMS & WILKINS　CIRCULATION   126 ( 21 )   2012.11（ ISSN:0009-7322 ）

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  • Percutaneous Carbon Dioxide Treatment Using a Gas Mist Generator Accelerates Angiogenesis in the Ischemic Hindlimb Reviewed

    Yasukatsu Izumi, Takanori Yamazaki, Yasuhiro Nakamura, Takehiro Yamaguchi, Akihisa Hanatani, Kenei Shimada, Minoru Yoshiyama, Hiroshi Iwao

    LIPPINCOTT WILLIAMS & WILKINS　CIRCULATION   126 ( 21 )   2012.11（ ISSN:0009-7322 ）

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    Publishing type：Article, review, commentary, editorial, etc. (scientific journal)  

  • The Efficacy of Tolvaptan on Renal Function under Reduced Loop Diuretics in Patients with Congestive Heart Failure Reviewed

    Akihisa Hanatani, Takanori Yamazaki, Kenichi Sugioka, Shoichi Ehara, Yasuhiro Nakamura, Yasukatsu Izumi, Yasuhiko Takemoto, Masahiko Takagi, Kenei Shimada, Minoru Yoshiyama

    CHURCHILL LIVINGSTONE INC MEDICAL PUBLISHERS　JOURNAL OF CARDIAC FAILURE   18 ( 10 )   S156 - S156   2012.10（ ISSN:1071-9164 ）

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    Publishing type：Article, review, commentary, editorial, etc. (scientific journal)  

  • 慢性心不全モデルラットに対するバソプレシンV2受容体拮抗薬トルバプタンの効果 Reviewed

    泉 康雄, 山崎 貴紀, 中村 泰浩, 高橋 延吉, 塩田 正之, 岡 真優子, 三浦 克之, 岩尾 洋

    (公社)日本薬理学会, 日本薬理学雑誌   140 ( 4 )   5P - 5P   2012.10（ ISSN:0015-5691 ）

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    Publishing type：Article, review, commentary, editorial, etc. (scientific journal)  

  • Nitric Oxide Synthase(NOS)阻害薬に対する種差 Reviewed

    泉 康雄, 中村 泰浩, 山崎 貴紀, 花谷 彰久, 島田 健永, 葭山 稔, 岩尾 洋

    (NPO)日本高血圧学会, 日本高血圧学会総会プログラム・抄録集   35回   427 - 427   2012.09

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    Publishing type：Article, review, commentary, editorial, etc. (scientific journal)  

  • 経皮的炭酸ガスミスト処置はラット心筋梗塞後の心機能低下を抑制する Reviewed

    泉 康雄, 高橋 延吉, 中村 泰浩, 山崎 貴紀, 塩田 正之, 田中 昌子, 山口 麻貴, 岡 真優子, 葭山 稔, 岩尾 洋

    日本心脈管作動物質学会, 血管   35 ( 1 )   47 - 47   2012.01（ ISSN:0911-4637 ）

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    Publishing type：Article, review, commentary, editorial, etc. (scientific journal)  

  • ラット心筋梗塞急性期に対するバゾプレシンV2受容体拮抗薬の効果

    泉康雄, 中村泰浩, 山崎貴紀, 高橋延吉, 岡真優子, 岡真優子, 塩田正之, 三浦克之, 岩尾洋

    日本循環薬理学会口演要旨集   22nd   2012

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  • 左房に限局するガリウムの異常集積と,全周性左房内膜肥厚を認めた発作性心房細動の一例

    柴田敦, 山崎貴紀, 伊藤朝広, 岩田真一, 松村嘉起, 江原省一, 花谷彰久, 島田健永, 葭山稔

    日本循環器学会近畿地方会(Web)   114th   2012

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  • II度以上未治療高血圧治療に対する高用量ARB投与とARB・CCB併用投与の降圧効果 Reviewed

    中村 泰浩, 泉 康雄, 山崎 貴紀, 花谷 彰久, 島田 健永, 室生 卓, 葭山 稔

    (NPO)日本高血圧学会, 日本高血圧学会総会プログラム・抄録集   34回   484 - 484   2011.10

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    Publishing type：Article, review, commentary, editorial, etc. (scientific journal)  

  • ラット心筋梗塞モデル慢性期に対するバソプレシンV2受容体拮抗薬トルバプタンの効果 Reviewed

    泉 康雄, 中村 泰浩, 山崎 貴紀, 花谷 彰久, 島田 健永, 室生 卓, 葭山 稔, 岩尾 洋

    (NPO)日本高血圧学会, 日本高血圧学会総会プログラム・抄録集   34回   410 - 410   2011.10

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    Publishing type：Article, review, commentary, editorial, etc. (scientific journal)  

  • Vasopressin V2 Receptor Antagonist Inhibits Cardiac Remodeling with Old Myocardial Infarction in Rats Reviewed

    Takanori Yamazaki, Yasuhiro Nakamura, Yasukatsu Izumi, Akihisa Hanatani, Takashi Muro, Minoru Yoshiyama

    CHURCHILL LIVINGSTONE INC MEDICAL PUBLISHERS　JOURNAL OF CARDIAC FAILURE   17 ( 9 )   S149 - S150   2011.09（ ISSN:1071-9164 ）

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    Publishing type：Article, review, commentary, editorial, etc. (scientific journal)  

  • 心筋梗塞後の心臓リモデリングに対するバゾプレシンV<sub>2</sub>受容体拮抗薬の効果

    泉康雄, 中村泰浩, 山崎貴紀, 高橋延吉, 塩田正之, 岡真優子, 岩尾洋

    日本循環薬理学会口演要旨集   21st   2011

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  • 高血圧性心肥大に対する抗線維化薬の効果

    泉康雄, 山崎貴紀, 中村泰浩, 花谷彰久, 室生卓, 葭山稔, 岩尾洋

    日本高血圧学会総会プログラム・抄録集   33rd   2010

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  • 僧帽弁瘤形成を伴ったMRSA感染性心内膜炎の1例

    安本 寛章, 泉谷 悟, 山崎 貴紀, 織田 茂哉, 田原 旭

    Circulation Journal   72 ( Suppl.II )   996 - 996   2008.04（ ISSN:1346-9843 ） （ eISSN:1347-4820 ）

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Presentations

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Incentive donations / subsidies

  • 血管内視鏡を用いた病変観察と分子マーカーの測定による、担癌患者の動脈血栓症発症予測因子の探索

    公益信託　循環器学研究振興機構  2019.04

  • 大豆イソフラボンによる血管周囲脂肪組織におけるGPR120の役割

    不二たんぱく質研究振興財団  2013.04

Outline of education staff

  • 胸部の診察
    虚血性心疾患の診断と治療

Charge of on-campus class subject

  • 心臓カテーテル実習

    2023   Practical Training   Undergraduate

  • 冠動脈疾患の最新の診断と治療

    2023     Graduate school

  • 虚血性心疾患の診断と治療

    2023     Undergraduate

  • 胸部聴診実習

    2023   Practical Training   Undergraduate

  • 心臓カテーテル実習

    2022   Practical Training   Undergraduate

  • 冠動脈疾患の最新の診断と治療

    2022     Graduate school

  • 虚血性心疾患の診断と治療

    2022     Undergraduate

  • 虚血性心疾患の診断と治療

    2021     Undergraduate

  • 心臓カテーテル実習

    2021   Practical Training   Undergraduate

  • 冠動脈疾患の最新の診断と治療

    2021     Graduate school

  • 胸部聴診実習

    2021   Practical Training   Undergraduate

  • 胸部聴診実習

    2020     Undergraduate

  • 虚血性心疾患の診断と治療

    2020     Undergraduate

  • 心臓カテーテル実習

    2020   Practical Training   Undergraduate

  • 心臓カテーテル実習

    2020   Practical Training   Undergraduate

  • 現代の医療

    2019     Undergraduate

  • 胸部聴診実習

    2019   Practical Training   Undergraduate

  • 症候学「胸痛」

    2019     Undergraduate

  • 心臓カテーテル実習

    2019   Practical Training   Undergraduate

  • 胸部聴診実習

    2018   Practical Training   Undergraduate

  • 症候学「胸痛」

    2018     Undergraduate

  • 心臓カテーテル実習

    2018   Practical Training   Undergraduate

▼display all

Charge of off-campus class subject

  • 臨床病態学「冠動脈疾患の最新の診断と治療」

    2021.09
    -
    Now

  • 臓器別講義「虚血性心疾患の診断と治療」

    2021.02
    -
    Now

  • 症候学「胸痛」

    2019.02
    -
    2020.03

  • 心臓カテーテル実習

    2018.04
    -
    Now

  • 胸部聴診実習

    2018
    -
    Now

Faculty development activities

  • 臨床研修指導医養成のためのワークショップ  2017

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    受講

Social Activities

  • 胸の痛み、続くならコロナ禍でも迷わず受診

    Role(s)： Media coverage

    朝日新聞  朝日新聞  2022.02

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    Type：Newspaper, magazine

Media Coverage

  • 胸の痛み、続くならコロナ禍でも迷わず受診 Newspaper, magazine

    朝日新聞  元気にキレイに  2022.02

Visiting Lectures　⇒ Link to the list of Visiting Lectures

  • 動脈硬化の成り立ち

    Category：Medicine (medical care, rehabilitation, health exercise science, physical fitness / training, sports practice science)

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    SDGs：

    Audience：Junior high school students,　High school students,　College students,　Graduate students,　Teachers,　Guardians,　General,　Company,　Civic organization,　Media

  • 急性冠症候群の診断・治療と予防について

    Category：Medicine (medical care, rehabilitation, health exercise science, physical fitness / training, sports practice science)

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    SDGs：

    Audience：High school students,　College students,　Graduate students,　General,　Civic organization,　Media

Academic Activities

  • 第17回Trans Catheter Imaging Forum

    Role(s)： Planning, management, etc.

    2024.05

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    Type：Academic society, research group, etc. 

  • 札幌心臓血管クリニックUltreon2.0 Web Live

    Role(s)： Panel moderator, session chair, etc.

    2023.12

    　More details

    Type：Academic society, research group, etc. 

  • ZIDAN-CLTI研究会

    Role(s)： Planning, management, etc.,　Panel moderator, session chair, etc.

    アステラス製薬・アムジェン株式会社  2023.12

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    Type：Academic society, research group, etc. 

  • 第41回日本心血管インターベンション治療学会近畿地方会

    Role(s)： Planning, management, etc.,　Panel moderator, session chair, etc.

    日本心血管インターベンション治療学会近畿支部  2023.10

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    Type：Academic society, research group, etc. 

  • 第20回近畿血管内視鏡研究会

    Role(s)： Planning, management, etc.,　Panel moderator, session chair, etc.

    2023.07

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    Type：Academic society, research group, etc. 

  • 第16回Trans Catheter Imaging Forum

    Role(s)： Panel moderator, session chair, etc.

    NPO法人日本血管映像化研究機構  2023.05

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    Type：Academic society, research group, etc. 

  • 第1回Metro Heart Conference

    Role(s)： Panel moderator, session chair, etc.

    大阪公立大学医学部附属病院循環器内科/第一三共株式会社  2023.05

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    Type：Academic society, research group, etc. 

  • 第87回日本循環器学会学術総会 Poster Session 87 PAD4

    Role(s)： Panel moderator, session chair, etc.

    日本循環器学会  2023.03

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    Type：Academic society, research group, etc. 

  • 第87回日本循環器学会学術総会

    Role(s)： Peer review

    日本循環器学会  2023.03

    　More details

    Type：Academic society, research group, etc. 

  • 第1回Osaka Metropolitan Cardiovascular Conference (OMECC)

    Role(s)： Planning, management, etc.,　Panel moderator, session chair, etc.

    日本メドトロニック  2023.02

    　More details

    Type：Academic society, research group, etc. 

  • 第4回PELE OSAKA

    Role(s)： Planning, management, etc.,　Panel moderator, session chair, etc.

    PHILIPS  2022.11

    　More details

    Type：Academic society, research group, etc. 

  • 第3回 ZIDAN-CLTI研究会

    Role(s)： Planning, management, etc.,　Panel moderator, session chair, etc.

    アステラス製薬・アムジェン株式会社  2022.05

    　More details

    Type：Academic society, research group, etc. 

  • BPA Conference 2022 in Osaka

    Role(s)： Panel moderator, session chair, etc.

    カネカメディックス  2022.05

    　More details

    Type：Academic society, research group, etc. 

  • 第86回日本循環器学会学術集会 ポスターセッション39 Atherosclerosis (Pathophysiology/Treatment)

    Role(s)： Panel moderator, session chair, etc.

    日本循環器学会  2022.03

    　More details

    Type：Academic society, research group, etc. 

  • 第86回日本循環器学会学術集会

    Role(s)： Peer review

    日本循環器学会  2022.03

    　More details

    Type：Peer review 

  • Complex Case Conference @Osaka

    Role(s)： Panel moderator, session chair, etc.

    ボストンサイエンティフィックジャパン  2021.12

    　More details

    Type：Academic society, research group, etc. 

  • 第2回 ZIDAN-CLTI研究会

    Role(s)： Planning, management, etc.,　Panel moderator, session chair, etc.

    アステラス製薬、アムジェン株式会社  2021.11

    　More details

    Type：Academic society, research group, etc. 

  • 第3回 PELE OSAKA

    Role(s)： Planning, management, etc.,　Panel moderator, session chair, etc.

    PHILIPS  2021.10

    　More details

    Type：Academic society, research group, etc. 

  • 第3回 OCU Heart Failure Web Meeting

    Role(s)： Panel moderator, session chair, etc.

    大塚製薬株式会社/ノバルティス・ファーマ株式会社  2021.08

    　More details

    Type：Academic society, research group, etc. 

  • CTEPH(慢性血栓塞栓性肺高血圧症)を知る

    Role(s)： Panel moderator, session chair, etc.

    第42回日本循環制御医学会学術集会・総会  2021.07

    　More details

    Type：Competition, symposium, etc. 

  • 静脈血栓症webセミナー〜エビデンスに基づいた正しいVTE診療を識る〜

    Role(s)： Panel moderator, session chair, etc.

    2021.06

    　More details

    Type：Academic society, research group, etc. 

  • ZIDAN-CLTI研究会

    Role(s)： Planning, management, etc.,　Panel moderator, session chair, etc.

    アステラス製薬、アムジェン  2021.05

    　More details

    Type：Academic society, research group, etc. 

  • 興和株式会社社内研修

    Role(s)： Review, evaluation

    興和株式会社  2021.05

    　More details

    Type：Scientific advice/Review 

  • ALI/CLI Summit「どうするALI (acute limb ischemia)」

    Role(s)： Panel moderator, session chair, etc.

    ボストンサイエンティフィックジャパン  2021.05

    　More details

    Type：Academic society, research group, etc. 

  • TCIF2021

    Role(s)： Panel moderator, session chair, etc.

    NPO法人日本血管映像化研究機構  2021.05

    　More details

    Type：Academic society, research group, etc. 

  • JCS2021 第85回日本循環器学会学術集会

    Role(s)： Peer review

    日本循環器学会  2021.03

    　More details

    Type：Academic society, research group, etc. 

  • EVT Web Seminar @OSAKA2020

    Role(s)： Panel moderator, session chair, etc.

    PHILIPS JAPAN  2020.12

    　More details

    Type：Academic society, research group, etc. 

  • 第2回 PELE OSAKA

    Role(s)： Planning, management, etc.,　Panel moderator, session chair, etc.

    アステラス製薬株式会社、アムジェン株式会社、PHILIPS JAPAN  2020.10

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    Type：Academic society, research group, etc. 

  • OSCE外部評価委員

    Role(s)： Review, evaluation

    神戸大学医学部  2019.12

    　More details

    Type：Scientific advice/Review 

  • CV Premium Conference

    Role(s)： Panel moderator, session chair, etc.

    アステラス・アムジェン  2019.11

    　More details

    Type：Academic society, research group, etc. 

  • 第12回近畿血管内視鏡研究会

    Role(s)： Panel moderator, session chair, etc.

    2019.10

    　More details

    Type：Academic society, research group, etc. 

  • PELE OSAKA

    Role(s)： Planning, management, etc.,　Panel moderator, session chair, etc.

    PHILIPS JAPAN  2019.10

    　More details

    Type：Academic society, research group, etc. 

  • 南大阪循環器PLUS2 -Practice Learning Unchained Study 2-

    Role(s)： Planning, management, etc.,　Panel moderator, session chair, etc.

    大塚製薬株式会社  2016.05

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    Type：Academic society, research group, etc. 

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Other

  • Job Career

    2019.04 - Now

    　 More details

    Osaka City University Graduate School of Medicine Internal Medicine of Cardiology Assistant Professor

  • Job Career

    2017.04 - 2019.03

    　 More details

    Osaka City University Graduate School of Medicine Internal Medicine of Cardiology Lecturer

  • Job Career

    2012.04 - 2014.03

    　 More details

    Osaka City University Graduate School of Medicine Internal Medicine of Cardiology Post Doctoral Fellow

  • Job Career

    2008.04 - 2012.03

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    Osaka City University Graduate School of Medicine Internal Medicine of Cardiology Graduate Student