Updated on 2024/04/12

写真a

 
Gi Min
 
Organization
Graduate School of Medicine Department of Basic Medical Science Associate Professor
School of Medicine Department of Medical Science
Title
Associate Professor
Affiliation
Institute of Medicine
Affiliation campus
Abeno Campus

Position

  • Graduate School of Medicine Department of Basic Medical Science 

    Associate Professor  2022.04 - Now

  • School of Medicine Department of Medical Science 

    Associate Professor  2022.04 - Now

Degree

  • 医学博士 ( Osaka City University )

Research Areas

  • Life Science / Experimental pathology  / Experimental Pathology

  • Life Science / Human pathology  / Hominal Pathology

Research Interests

  • cancer chemoprevention

  • 発がん病理

  • Experimental animal model

  • chemical carcinogenesis

  • Risk Assessment

Research subject summary

  • 実験病理学
    化学発がん
    化学物質リスクアセスメント
    がん予防
    腫瘍分子病理学

Research Career

  • 化学物質のリスク評価

    1996.04 - Now 

  • chemical carcinogenesis

    Chemical carcinogenesis, Cancer risk assessment, Arsenic  Joint Research in Organization

    1997.04 - Now 

  • Cancer chemoprevention

    Urinary bladder cancer, Liver cancer, Colon cancer  Joint Research in Organization

    1997.04 - Now 

  • Molecular carcinogenesis

    Urinary bladder, Biomarker for carcinogenesis, microRNA  Joint Research in Organization

    1996.04 - Now 

Professional Memberships

  • Japanese Cancer Association

      Domestic

  • The Japanese Society of Pathology

      Domestic

  • The Japanese Society of Toxicologic Pathology

      Domestic

  • 日本毒性学会

      Domestic

  • Asian Union of Toxicologic Pathology

    2021.12 - Now   Overseas

  • 日本産業衛生学会

    2019 - Now

  • American Association for Cancer Rsearch

      Overseas

  • JAPANESE ASSOCIATION FOR LABORATORY ANIMAL SCIENCE

  • 日本がん予防学会

  • 日本食品化学学会

  • 日本ヒ素研究会

▼display all

Committee Memberships (off-campus)

  • 評議員   日本癌学会  

    2019.01 - Now 

  • 理事   日本毒性病理学会  

    2019.01 - Now 

  • 理事   毒性病理学会アジア毒性病理学連盟  

    2021.12 - Now 

  • ヒト生命科学研究倫理審査委員会委員   住友化学株式会社  

    2023.04 - Now 

  • 理事   日本ヒ素研究会  

    2023.04 - Now 

  • 評議員   日本毒性学会  

    2020.06 - Now 

  • 代議員   日本産業衛生学会  

    2020.04 - Now 

  • 薬事・食品衛生審議会 臨時委員   厚生労働省 医薬・生活衛生局  

    2018.01 - 2024.03 

  • 編集委員   日本食品化学学会  

    2017.01 - Now 

  • 評議員   日本毒性病理学会  

    2014 - Now 

  • 評議員   日本病理学会  

    2014 - Now 

  • 教育委員   日本毒性病理学会  

    2014 - 2019.03 

▼display all

Awards

  • 大阪市医学会学会賞

    2020.03  

  • 大阪市立大学 医学部長賞奨励賞

    2019.03  

  • 日本毒性学会田邊賞

    2017.07  

Job Career (off-campus)

  • 米国ネブラスカ大学   医学部   リサーチアソシエイト

    2002.08 - 2004.07

Education

  • Osaka City University   pathology   Doctor's Course   Graduated/Completed

    - 2001

  • SHENYANG MEDICAL COLLEGE     Graduated/Completed

    - 1993

Papers

  • A novel support vector machine-based one-day, single-dose prediction model of genotoxic hepatocarcinogenicity in rats Reviewed

    Gi M, Suzuki S, Kanki M, Yokohira M, Tsukamoto T, Fujioka M, Vachiraarunwong A, Qiu G, Guo R, Wanibuchi H

    2024.03

     More details

    Authorship:Lead author   Publishing type:Research paper (scientific journal)   International / domestic magazine:International journal  

  • Characterizing the toxicological responses to inorganic arsenicals and their metabolites in immortalized human bladder epithelial cells Reviewed

    Vachiraarunwong A, Gi M, Kiyono T, Suzuki S, Fujioka M, Qiu G, Guo R, Yamamoto T, Kakehashi A, Shiota M, Wanibuchi H.

    2024.03

     More details

    Authorship:Corresponding author   Publishing type:Research paper (scientific journal)   International / domestic magazine:International journal  

  • Inulin alleviates perfluorooctanoic acid-induced intestinal injury in mice by modulating the PI3K/AKT/mTOR signaling pathway. Reviewed International coauthorship

    Zhang QY, Zhong MT, Gi M, Chen YK, Lai MQ, Liu JY, Liu YM, Wang Q, Xie XL

    Environmental pollution   342   123090   2024.02( ISSN:0269-7491

     More details

    Publishing type:Research paper (scientific journal)   International / domestic magazine:International journal  

    DOI: 10.1016/j.envpol.2023.123090

    PubMed

  • Evaluation of the Mechanisms Involved in the Development of Bladder Toxicity following Exposure to Occupational Bladder Cancer Causative Chemicals Using DNA Adductome Analysis Reviewed

    Shugo Suzuki, Min Gi, Masami Komiya, Asuka Obikane, Arpamas Vachiraarunwong, Masaki Fujioka, Anna Kakehashi, Yukari Totsuka, Hideki Wanibuchi

    Biomolecules   14 ( 1 )   2023.12

     More details

    Publishing type:Research paper (scientific journal)   International / domestic magazine:International journal  

    DOI: 10.3390/biom14010036

    PubMed

  • Interpretation of in vitro concentration-response data for risk assessment and regulatory decision-making: Report from the 2022 IWGT quantitative analysis expert working group meeting. Reviewed International coauthorship

    Beal MA, Chen G, Dearfield KL, Gi M, Gollapudi B, Heflich RH, Horibata K, Long AS, Lovell DP, Parsons BL, Pfuhler S, Wills J, Zeller A, Johnson G, White PA

    Environmental and molecular mutagenesis   2023.12( ISSN:0893-6692

     More details

    Publishing type:Research paper (scientific journal)   International / domestic magazine:International journal  

    DOI: 10.1002/em.22582

    PubMed

  • DNA Methylation Aberrations in Dimethylarsinic Acid-Induced Bladder Carcinogenesis. Reviewed

    Tomoki Yamamoto, Min Gi, Satoshi Yamashita, Shugo Suzuki, Masaki Fujioka, Arpamas Vachiraarunwong, Runjie Guo, Guiyu Qiu, Anna Kakehashi, Minoru Kato, Junji Uchida, Hideki Wanibuchi

    Cancers   15 ( 21 )   2023.11( ISSN:2072-6694

     More details

    Authorship:Lead author   Publishing type:Research paper (scientific journal)   International / domestic magazine:International journal  

    Arsenic is a known human urinary bladder carcinogen. While arsenic is known to cause aberrant DNA methylation, the mechanism of arsenic-triggered bladder carcinogenesis is not fully understood. The goal of this study was to identify aberrant DNA methylation in rat bladder urothelial carcinoma (UC) induced by dimethylarsinic acid (DMAV), a major organic metabolite of arsenic. We performed genome-wide DNA methylation and microarray gene expression analyses of DMAV-induced rat UCs and the urothelium of rats treated for 4 weeks with DMAV. We identified 40 genes that were both hypermethylated and downregulated in DMAV-induced rat UCs. Notably, four genes (CPXM1, OPCML, TBX20, and KCND3) also showed reduced expression in the bladder urothelium after 4 weeks of exposure to DMAV. We also found that CPXM1 is aberrantly methylated and downregulated in human bladder cancers and human bladder cancer cells. Genes with aberrant DNA methylation and downregulated expression in DMAV-exposed bladder urothelium and in DMAV-induced UCs in rats, suggest that these alterations occurred in the early stages of arsenic-induced bladder carcinogenesis. Further study to evaluate the functions of these genes will advance our understanding of the role of aberrant DNA methylation in arsenic bladder carcinogenesis, and will also facilitate the identification of new therapeutic targets for arsenic-related bladder cancers.

    DOI: 10.3390/cancers15215274

    PubMed

  • Early detection of genotoxic hepatocarcinogens in rats using γH2AX and Ki-67: prediction by machine learning. Reviewed

    Michiba A, Gi M, Yokohira M, Sakurai E, Teramoto A, Kiriyama Y, Yamada S, Wanibuchi H, Tsukamoto T

    Toxicological sciences : an official journal of the Society of Toxicology   195 ( 2 )   202 - 212   2023.09

     More details

    Publishing type:Research paper (scientific journal)   International / domestic magazine:International journal  

    DOI: 10.1093/toxsci/kfad073

    PubMed

  • Dimethylarsinic acid induces bladder carcinogenesis via the amphiregulin pathway. Reviewed

    Shugo Suzuki, Min Gi, Masaki Fujioka, Anna Kakehashi, Hideki Wanibuchi

    Toxicology letters   384   128 - 135   2023.08( ISSN:0378-4274

     More details

    Publishing type:Research paper (scientific journal)   International / domestic magazine:International journal  

    Dimethylarsinic acid (DMA) is a major metabolite in the urine of humans and rats exposed to inorganic arsenicals, and is reported to induce rat bladder carcinogenesis. In the present study, we focused on early pathways of carcinogenesis triggered by DMA that were also active in tumors. RNA expression in the bladder urothelium of rats treated with 0 and 200 ppm DMA in the drinking water for 4 weeks and in bladder tumors of rats treated with 200 ppm DMA for 2 years was initially examined using microarray analysis and Ingenuity Pathway Analysis (IPA). Expression of 160 genes was altered in both the urothelium of rats treated for 4 weeks with DMA and in DMA-induced tumors. IPA associated 36 of these genes with liver tumor diseases. IPA identified the amphiregulin (Areg)-regulated pathway as a Top Regulator Effects Network. Therefore, we focused on Areg and 6 of its target genes: cyclin A2, centromere protein F, marker of proliferation Ki-67, protein regulator of cytokinesis 1, ribonucleotide reductase M2, and topoisomerase II alpha. We confirmed high mRNA expression of Areg and its 6 target genes in both the urothelium of rats treated for 4 weeks with DMA and in DMA-induced tumors. RNA interference of human amphiregulin (AREG) expression in human urinary bladder cell lines T24 and UMUC3 decreased expression of AREG and its 6 target genes and decreased cell proliferation. These data suggest that Areg has an important role in DMA-induced rat bladder carcinogenesis.

    DOI: 10.1016/j.toxlet.2023.08.004

    PubMed

  • Irradiation plus myeloid-derived suppressor cell-targeted therapy for overcoming treatment resistance in immunologically cold urothelial carcinoma. Reviewed

    Shoma Yamamoto, Minoru Kato, Yuji Takeyama, Yukari Azuma, Nao Yukimatsu, Yukiyoshi Hirayama, Taiyo Otoshi, Takeshi Yamasaki, Masaki Fujioka, Min Gi, Hideki Wanibuchi, Junji Uchida

    British journal of cancer   2023.04( ISSN:0007-0920

     More details

    Publishing type:Research paper (scientific journal)   International / domestic magazine:International journal  

    BACKGROUND: Radiotherapy (RT) has recently been highlighted as a partner of immune checkpoint inhibitors. The advantages of RT include activation of lymphocytes while it potentially recruits immunosuppressive cells, such as myeloid-derived suppressor cells (MDSCs). This study aimed to investigate the mechanism of overcoming treatment resistance in immunologically cold tumours by combining RT and MDSC-targeted therapy. METHODS: The abscopal effects of irradiation were evaluated using MB49 and cisplatin-resistant MB49R mouse bladder cancer cells, with a focus on the frequency of immune cells and programmed cell death-ligand 1 (PD-L1) expression in a xenograft model. RESULTS: MB49R was immunologically cold compared to parental MB49 as indicated by the fewer CD8+ T cells and lower PD-L1 expression. Polymorphonuclear MDSCs increased in both MB49 and MB49R abscopal tumours, whereas the infiltration of CD8+ T cells increased only in MB49 but not in MB49R tumours. Interestingly, PD-L1 expression was not elevated in abscopal tumours. Finally, blocking MDSC in combination with RT remarkably reduced the growth of both MB49 and MB49R abscopal tumours regardless of the changes in the frequency of infiltrating CD8+ T cells. CONCLUSIONS: The combination of RT and MDSC-targeted therapy could overcome treatment resistance in immunologically cold tumours.

    DOI: 10.1038/s41416-023-02244-8

    PubMed

  • A carcinogenicity study of diphenylarsinic acid in C57BL/6J mice in drinking water for 78 weeks. Reviewed

    Yamaguchi T, Gi M, Fujioka M, Suzuki S, Oishi Y, Wanibuchi H

    Journal of toxicologic pathology   36 ( 2 )   123 - 129   2023.04( ISSN:0914-9198

     More details

    Publishing type:Research paper (scientific journal)   International / domestic magazine:International journal  

    DOI: 10.1293/tox.2022-0111

    PubMed

  • o-Toluidine metabolism and effects in the urinary bladder of humanized-liver mice. Reviewed

    Yuka Yokota, Shugo Suzuki, Min Gi, Yukie Yanagiba, Nao Yoneda, Masaki Fujioka, Anna Kakehashi, Shigeki Koda, Hiroshi Suemizu, Hideki Wanibuchi

    Toxicology   488   153483 - 153483   2023.03( ISSN:0300-483X

     More details

    Publishing type:Research paper (scientific journal)   International / domestic magazine:International journal  

    Occupational exposure to aromatic amines is one of the most important risk factors for urinary bladder cancer. When considering the carcinogenesis of aromatic amines, metabolism of aromatic amines in the liver is an important factor. In the present study, we administered ortho-toluidine (OTD) in the diet to mice for 4 weeks. We used NOG-TKm30 mice (control) and humanized-liver mice, established via human hepatocyte transplantation, to compare differences in OTD-induced expression of metabolic enzymes in human and mouse liver cells. We also investigated OTD-urinary metabolites and proliferative effects on the urinary bladder epithelium. RNA and immunohistochemical analyses revealed that expression of N-acetyltransferases mRNA in the liver tended to be lower than that of the P450 enzymes, and that OTD administration had little effect on N-acetyltransferase mRNA expression levels. However, expression of CYP3A4 was increased in the livers of humanized-liver mice, and expression of Cyp2c29 (human CYP2C9/19) was increased in the livers of NOG-TKm30 mice. OTD metabolites in the urine and cell proliferation activities in the bladder urothelium of NOG-TKm30 and humanized-liver mice were similar. However, the concentration of OTD in the urine of NOG-TKm30 mice was markedly higher than in the urine of humanized-liver mice. These data demonstrate differences in hepatic metabolic enzyme expression induced by OTD in human and mouse liver cells, and consequent differences in the metabolism of OTD by human and mouse liver cells. This type of difference could have a profound impact on the carcinogenicity of compounds that are metabolized by the liver, and consequently, would be important in the extrapolation of data from animals to humans.

    DOI: 10.1016/j.tox.2023.153483

    PubMed

  • OTUD1 deubiquitinase regulates NF-κB- and KEAP1-mediated inflammatory responses and reactive oxygen species-associated cell death pathways.

    Oikawa D, Gi M, Kosako H, Shimizu K, Takahashi H, Shiota M, Hosomi S, Komakura K, Wanibuchi H, Tsuruta D, Sawasaki T, Tokunaga F

    Cell death & disease   13 ( 8 )   694   2022.08

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41419-022-05145-5

    PubMed

  • The carbonic anhydrase inhibitor acetazolamide inhibits urinary bladder cancers via suppression of β-catenin signaling.

    Taisuke Matsue, Min Gi, Masayuki Shiota, Hirokazu Tachibana, Shugo Suzuki, Masaki Fujioka, Anna Kakehashi, Tomoki Yamamoto, Minoru Kato, Junji Uchida, Hideki Wanibuchi

    Cancer science   113 ( 8 )   2642 - 2653   2022.08( ISSN:1347-9032

     More details

    Publishing type:Research paper (scientific journal)   International / domestic magazine:International journal  

    Carbonic anhydrases (CAs) play an important role in maintaining pH homeostasis. We previously demonstrated that overexpression of CA2 was associated with invasion and progression of urothelial carcinoma (UC) in humans. The purpose of the present study was to evaluate the effects of the CA inhibitor acetazolamide (Ace) on N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN)-induced bladder carcinogenesis in mice and explore the function of CA2 in muscle invasion by UC. Male mice were treated with 0.025% (experiment 1) or 0.05% BBN (experiment 2) in their drinking water for 10 weeks, then treated with cisplatin (Cis), Ace, or Cis plus Ace for 12 weeks. In experiment 1, the overall incidence of BBN-induced UCs was significantly decreased in the BBN→Ace and BBN→Cis+Ace groups. In experiment 2, the overall incidence of BBN-induced UCs was significantly decreased in the BBN→Cis+Ace group, and the incidence of muscle invasive UC was significantly decreased in both the BBN→Ace and the BBN→Cis+Ace groups. We also show that overexpression of CA2 by human UC cells T24 and UMUC3 significantly increased their migration and invasion capabilities, and that Ace significantly inhibited migration and invasion by CA2-overexpressing T24 and UMUC3 cells. These data demonstrate a functional association of CA2 with UC development and progression, confirming the association of CA2 with UC that we had shown previously by immunohistochemical analysis of human UC specimens and proteome analysis of BBN-induced UC in rats. Our finding that inhibition of CA2 inhibits UC development and muscle invasion also directly confirms that CA2 is a potential therapeutic target for bladder cancers.

    DOI: 10.1111/cas.15467

    PubMed

  • Response biomarkers of inhalation exposure to cigarette smoke in the mouse lung.

    Suzuki S, Asai K, Gi M, Kojima K, Kakehashi A, Oishi Y, Matsue T, Yukimatsu N, Hirata K, Kawaguchi T, Wanibuchi H

    Journal of toxicologic pathology   35 ( 3 )   247 - 254   2022.07( ISSN:0914-9198

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.1293/tox.2021-0077

    PubMed

  • Interplay between protein acetylation and ubiquitination controls MCL1 protein stability.

    Kouhei Shimizu, Min Gi, Shugo Suzuki, Brian J North, Asami Watahiki, Satoshi Fukumoto, John M Asara, Fuminori Tokunaga, Wenyi Wei, Hiroyuki Inuzuka

    Cell reports   37 ( 6 )   109988 - 109988   2021.11

     More details

    Publishing type:Research paper (scientific journal)   International / domestic magazine:International journal  

    The anti-apoptotic myeloid cell leukemia 1 (MCL1) protein belongs to the pro-survival BCL2 family and is frequently amplified or elevated in human cancers. MCL1 is highly unstable, with its stability being regulated by phosphorylation and ubiquitination. Here, we identify acetylation as another critical post-translational modification regulating MCL1 protein stability. We demonstrate that the lysine acetyltransferase p300 targets MCL1 at K40 for acetylation, which is counteracted by the deacetylase sirtuin 3 (SIRT3). Mechanistically, acetylation enhances MCL1 interaction with USP9X, resulting in deubiquitination and subsequent MCL1 stabilization. Therefore, ectopic expression of acetylation-mimetic MCL1 promotes apoptosis evasion of cancer cells, enhances colony formation potential, and facilitates xenografted tumor progression. We further demonstrate that elevated MCL1 acetylation sensitizes multiple cancer cells to pharmacological inhibition of USP9X. These findings reveal that acetylation of MCL1 is a critical post-translational modification enhancing its oncogenic function and provide a rationale for developing innovative therapeutic strategies for MCL1-dependent tumors.

    DOI: 10.1016/j.celrep.2021.109988

    PubMed

  • p300によるアセチル化は抗アポトーシス因子MCL1の安定化と腫瘍形成を促進する

    清水 康平, 魏 民, 鈴木 周五, 徳永 文稔, 犬塚 博之, Wei Wenyi

    日本生化学会大会プログラム・講演要旨集   94回   [2T13a - 483)]   2021.11

     More details

    Publishing type:Research paper (scientific journal)  

  • Canopy Homolog 2 as a Novel Molecular Target in Hepatocarcinogenesis.

    Anna Kakehashi, Shugo Suzuki, Masayuki Shiota, Nina Raymo, Min Gi, Taro Tachibana, Vasily Stefanov, Hideki Wanibuchi

    Cancers   13 ( 14 )   2021.07( ISSN:2072-6694

     More details

    Publishing type:Research paper (scientific journal)   International / domestic magazine:International journal  

    In the present study, the role of a novel protein involved in neurite development and endoplasmic reticulum (ER) stress, canopy homolog 2 (CNPY2), was investigated in mouse and human hepatocarcinogenesis. Firstly, a sensitive quantitative and qualitative detection of protein expression using QSTAR Elite LC-Ms/Ms was performed for the analysis of lysates of microdissected hepatocellular altered foci (AF), adenomas (HCAs), carcinomas (HCCs) and peri-tumoral livers from C57Bl/6J mice treated with diethylnitrosamine (DEN) and then maintained for 27 or 38 weeks on basal diet. Significant overexpression of 18.5 kDa CNPY2 processed form was demonstrated in AF, HCAs and HCCs, while low expression was observed in the livers of DEN-treated and control mice. Furthermore, CNPY2 elevation in AF and tumors was coordinated with accumulation of numerous cytoskeletal proteins, including cytokeratins 8 and 18, actin, non-muscle myosin and septin 9 and those involved in ER and mitochondrial stresses such as calreticulin, prohibitins 1 and 2 and YME1-like-1. Knockdown of CNPY2 in Huh7 and HepG2 human liver cancer cells resulted in significant suppression of cell survival and invasive potential, inhibition of cyclin D1, induction of p21Waf1/Cip1 and suppression of the apoptosis inhibitor Bcl2. In contrast, transfection of a mouse CNPY2 (mCNPY2-Ds-Red) vector plasmid in Huh7 and HepG2 cancer cells, with subsequent accumulation of CNPY2 in the ER, resulted in significant increase in cancer cells survival. Clinicopathological analysis in 90 HCV-positive HCC patients, revealed significant association of CNPY2 overexpression with poor overall (p = 0.041) survival. Furthermore, CNPY2 increase was associated with vessel invasion (p = 0.038), poor histological differentiation (p = 0.035) and advanced clinical stage (p = 0.016). In conclusion, CNPY2 is a promising molecular target elevated early in hepatocarcinogenesis and prognostic marker for human HCV-associated HCC. CNPY2 is involved in the processes of ER stress, cell cycle progression, proliferation, survival and invasion of liver tumor cells.

    DOI: 10.3390/cancers13143613

    PubMed

  • Cache Domain Containing 1 Is a Novel Marker of Non-Alcoholic Steatohepatitis-Associated Hepatocarcinogenesis. Reviewed

    Kakehashi A, Chariyakornkul A, Suzuki S, Khuanphram N, Tatsumi K, Yamano S, Fujioka M, Gi M, Wongpoomchai R, Wanibuchi H

    Cancers   13 ( 6 )   2021.03

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.3390/cancers13061216

    PubMed

  • Cell proliferation of rat bladder urothelium induced by nicotine is suppressed by the NADPH oxidase inhibitor, apocynin. Reviewed

    Suzuki S, Cohen SM, Arnold LL, Pennington KL, Gi M, Kato H, Naiki T, Naiki-Ito A, Wanibuchi H, Takahashi S

    Toxicology letters   336   32 - 38   2021.01( ISSN:0378-4274

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.toxlet.2020.11.005

    PubMed

  • Accumulation of 8-hydroxydeoxyguanosine, L-arginine and Glucose Metabolites by Liver Tumor Cells Are the Important Characteristic Features of Metabolic Syndrome and Non-Alcoholic Steatohepatitis-Associated Hepatocarcinogenesis. Reviewed

    Kakehashi A, Suzuki S, Ishii N, Okuno T, Kuwae Y, Fujioka M, Gi M, Stefanov V, Wanibuchi H

    International journal of molecular sciences   21 ( 20 )   2020.10

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.3390/ijms21207746

    PubMed

  • Role of γ-H2AX as a biomarker for detection of bladder carcinogens in F344 rats. Reviewed

    Suzuki S, Gi M, Toyoda T, Kato H, Naiki-Ito A, Kakehashi A, Ogawa K, Takahashi S, Wanibuchi H

    Journal of toxicologic pathology   33 ( 4 )   279 - 285   2020.10( ISSN:0914-9198

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.1293/tox.2020-0038

    PubMed

  • Myeloid-derived suppressor cells are essential partners for immune checkpoint inhibitors in the treatment of cisplatin-resistant bladder cancer. Reviewed

    Takeyama Y, Kato M, Tamada S, Azuma Y, Shimizu Y, Iguchi T, Yamasaki T, Gi M, Wanibuchi H, Nakatani T

    Cancer letters   479   89 - 99   2020.06( ISSN:0304-3835

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.canlet.2020.03.013

    PubMed

  • Myeloid-derived suppressor cells are essential partners for immune checkpoint inhibitors in the treatment of cisplatin-resistant bladder cancer.

    Takeyama Y, Kato M, Tamada S, Azuma Y, Shimizu Y, Iguchi T, Yamasaki T, Gi M, Wanibuchi H, Nakatani T

    Cancer letters   479   89 - 99   2020.06( ISSN:0304-3835

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.canlet.2020.03.013

    PubMed

  • Dimethylarsinic acid (DMA) enhanced lung carcinogenesis via histone H3K9 modification in a transplacental mouse model. Reviewed

    Fujioka M, Suzuki S, Gi M, Kakehashi A, Oishi Y, Okuno T, Yukimatsu N, Wanibuchi H

    Archives of toxicology   2020.02( ISSN:0340-5761

  • Comprehensive analysis of DNA adducts (DNA adductome analysis) in the liver of rats treated with 1,4-dioxane. Reviewed

    Totsuka Y, Maesako Y, Ono H, Nagai M, Kato M, Gi M, Wanibuchi H, Fukushima S, Shiizaki K, Nakagama H

    Proceedings of the Japan Academy. Series B, Physical and biological sciences   96 ( 5 )   180 - 187   2020( ISSN:0386-2208

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.2183/pjab.96.015

    PubMed

  • Promotion effects of acetoaceto-o-toluidide on N-butyl-N-(4-hydroxybutyl)nitrosamine-induced bladder carcinogenesis in rats Reviewed

    Nao Yukimatsu, Min Gi, Takahiro Okuno, Masaki Fujioka, Shugo Suzuki, Anna Kakehashi, Yukie Yanagiba, Megumi Suda, Shigeki Koda, Tatsuya Nakatani, Hideki Wanibuchi

    Archives of Toxicology   93 ( 12 )   3617 - 3631   2019.12( ISSN:0340-5761

     More details

    Publishing type:Research paper (scientific journal)  

    © 2019, Springer-Verlag GmbH Germany, part of Springer Nature. Recent epidemiological studies have indicated that occupational exposure to the aromatic amine acetoaceto-o-toluidide (AAOT) was associated with a marked increase in urinary bladder cancers in Japan. However, little is known about the carcinogenicity of AAOT. To evaluate the urinary bladder carcinogenicity of AAOT, male and female F344 rats were treated with N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN) for 4 weeks followed by dietary administration of 0, 0.167, 0.5, or 1.5% AAOT for 31 weeks. The incidences and multiplicities of bladder tumors were significantly increased in the 0.5 and 1.5% groups of male and female rats in a dose-response manner. AAOT and seven downstream metabolites were detected in the urine of the male and female rats administered AAOT with levels increasing in a dose-dependent manner. The most abundant urinary metabolite of AAOT was the human bladder carcinogen o-toluidine (OTD), which was at least one order of magnitude higher than AAOT and the other AAOT metabolites. In a second experiment, male F344 rats were administered 0, 0.167, or 1.5% AAOT for 4 weeks. Gene expression analyses revealed that the expression of JUN and its downstream target genes was increased in the urothelium of male rats treated with 1.5% AAOT. These results demonstrate that AAOT promotes BBN-induced urinary bladder carcinogenesis in rats and suggest that overexpressed of JUN and its downstream target genes may be involved the bladder carcinogenicity of AAOT. In conclusion, AAOT, like other carcinogenic aromatic amines, is likely to be a carcinogen to the urinary bladder, and OTD metabolized from AAOT is the ultimate carcinogen.

    DOI: 10.1007/s00204-019-02605-4

    PubMed

  • Long-term administration of excess zinc impairs learning and memory in aged mice Reviewed

    Yoshida K, Gi M, Fujioka M, Teramoto I and Wanibuchi H.

    J Toxicol Sci   44 ( 10 )   681 - 691   2019.10

  • Promotion effects of acetoaceto-o-toluidide on N-butyl-N-(4-hydroxybutyl)nitrosamine-induced bladder carcinogenesis in rats Reviewed

    Yukimatsu N, Gi M, Okuno T, Fujioka M, Suzuki S, Kakehashi A, Yanagiba Y, Suda M, Koda S, Nakatani T and Wanibuchi H

    Arch Toxicol   93   2019 - 3631   2019.10

  • Quantitative analysis of mutagenicity and carcinogenicity of 2-amino-3-methylimidazo[4,5-f]quinoline in F344 gpt delta transgenic rats. Reviewed

    Gi M, Fujioka M, Totsuka Y, Matsumoto M, Masumura K, Kakehashi A, Yamaguchi T, Fukushima S, Wanibuchi H

    Mutagenesis   34 ( 3 )   279 - 287   2019.09( ISSN:0267-8357

     More details

  • A chronic toxicity study of diphenylarsinic acid in the drinking water of C57BL/6J mice for 52 weeks. Reviewed

    Yamaguchi T, Gi M, Fujioka M, Tago Y, Kakehashi A, Wanibuchi H

    Journal of toxicologic pathology   32 ( 3 )   127 - 134   2019.07( ISSN:0914-9198

     More details

  • Acetoaceto-o-Toluidide Enhances Cellular Proliferative Activity in the Urinary Bladder of Rats. Reviewed

    Okuno T, Gi M, Fujioka M, Yukimatu N, Kakehashi A, Takeuchi A, Endo G, Endo Y, Wanibuchi H

    Toxicological sciences : an official journal of the Society of Toxicology   169 ( 2 )   456 - 464   2019.06( ISSN:1096-6080

     More details

  • Long-term administration of excess zinc impairs learning and memory in aged mice. Reviewed

    Kaoru Yoshida, Min Gi, Masaki Fujioka, Isao Teramoto, Hideki Wanibuchi

    The Journal of toxicological sciences   44 ( 10 )   681 - 691   2019( ISSN:0388-1350

     More details

    Publishing type:Research paper (scientific journal)   International / domestic magazine:Domestic journal  

    Zinc (Zn) is an essential element, but excess amounts are known to cause neurotoxic effects. The risk of excessive Zn intake is increased by supplementing food intake with dietary supplements. Ageing affects many cellular processes that predispose individuals to neurodegeneration. Indeed, the prevalence of senile dementia such as Alzheimer's disease, Parkinson's disease, and vascular-type dementia increases with age. As such, we investigated the effects of long-term exposure to excess Zn on learning and memory in aged mice. ICR-JCL female mice (aged 26 weeks) were administered 0, 200, or 500 ppm Zn as zinc chloride in drinking water for 30 weeks. After 30-week administration, aged female animals were subjected to Y-maze, novel object recognition, and step-through passive avoidance tests. Chronic exposure to Zn did not inhibit learning and memory in the Y-maze test, but dose-dependently inhibited learning and memory in novel object recognition and step-through passive avoidance tests. These results indicate the potential for chronic Zn exposure to dose-dependently inhibit both long-term and novel object recognition memory. Results of microarray analysis revealed significant changes in gene expression of transthyretin and many olfactory receptors in the hippocampus of Zn-treated mice.

    DOI: 10.2131/jts.44.681

    PubMed

  • Long-term administration of excess zinc impairs learning and memory in aged mice Reviewed

    Kaoru Yoshida, Min Gi, Masaki Fujioka, Isao Teramoto, Hideki Wanibuchi

    Journal of Toxicological Sciences   44 ( 10 )   681 - 691   2019( ISSN:1880-3989

     More details

    Publishing type:Research paper (scientific journal)   International / domestic magazine:Domestic journal  

    © 2019, Japanese Society of Toxicology. All rights reserved. — Zinc (Zn) is an essential element, but excess amounts are known to cause neurotoxic effects. The risk of excessive Zn intake is increased by supplementing food intake with dietary supplements. Ageing affects many cellular processes that predispose individuals to neurodegeneration. Indeed, the prevalence of senile dementia such as Alzheimer’s disease, Parkinson’s disease, and vascular-type dementia increases with age. As such, we investigated the effects of long-term exposure to excess Zn on learning and memory in aged mice. ICR-JCL female mice (aged 26 weeks) were administered 0, 200, or 500 ppm Zn as zinc chloride in drinking water for 30 weeks. After 30-week administration, aged female animals were subjected to Y-maze, novel object recognition, and step-through passive avoidance tests. Chronic exposure to Zn did not inhibit learning and memory in the Y-maze test, but dose-dependently inhibited learning and memory in novel object recognition and step-through passive avoidance tests. These results indicate the potential for chronic Zn exposure to dose-dependently inhibit both long-term and novel object recognition memory. Results of microarray analysis revealed significant changes in gene expression of transthyretin and many olfactory receptors in the hippocampus of Zn-treated mice.

    DOI: 10.2131/jts.44.681

    PubMed

  • Chronic dietary toxicity and carcinogenicity studies of dammar resin in F344 rats.

    Gi M, Fujioka M, Yamano S, Kakehashi A, Oishi Y, Okuno T, Yukimatsu N, Yamaguchi T, Tago Y, Kitano M, Hayashi SM, Wanibuchi H

    Archives of toxicology   92 ( 12 )   3565 - 3583   2018.12( ISSN:0340-5761

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00204-018-2316-7

    PubMed

  • Steroid sulfatase promotes invasion through epithelial-mesenchymal transition and predicts the progression of bladder cancer.

    Shimizu Y, Tamada S, Kato M, Takeyama Y, Fujioka M, Kakehashi A, Nakatani T, Wanibuchi H, Gi M

    Experimental and therapeutic medicine   16 ( 6 )   4463 - 4470   2018.12( ISSN:1792-0981

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.3892/etm.2018.6787

    PubMed

  • mTOR Activation in Liver Tumors Is Associated with Metabolic Syndrome and Non-Alcoholic Steatohepatitis in Both Mouse Models and Humans.

    Okuno T, Kakehashi A, Ishii N, Fujioka M, Gi M, Wanibuchi H

    Cancers   10 ( 12 )   2018.11( ISSN:2072-6694

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.3390/cancers10120465

    PubMed

  • In vivo positive mutagenicity of 1,4-dioxane and quantitative analysis of its mutagenicity and carcinogenicity in rats.

    Gi M, Fujioka M, Kakehashi A, Okuno T, Masumura K, Nohmi T, Matsumoto M, Omori M, Wanibuchi H, Fukushima S

    Archives of toxicology   92 ( 10 )   3207 - 3221   2018.10( ISSN:0340-5761

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00204-018-2282-0

    PubMed

  • Quantitative Approaches to Assess Key Carcinogenic Events of Genotoxic Carcinogens.

    Fukushima S, Gi M, Fujioka M, Kakehashi A, Wanibuchi H, Matsumoto M

    Toxicological research   34 ( 4 )   291 - 296   2018.10( ISSN:1976-8257

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.5487/TR.2018.34.4.291

    PubMed

  • Quantitative Approaches to Assess Key Carcinogenic Events of Genotoxic Carcinogens Reviewed

    Fukushima, S. and Gi, M. and Fujioka, M. and Kakehashi, A. and Wanibuchi, H. and Matsumoto, M.

    Toxicol Res   34 ( 4 )   291 - 296   2018

     More details

    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

  • Steroid sulfatase promotes invasion through epithelial-mesenchymal transition and predicts the progression of bladder cancer Reviewed

    Shimizu, Y. and Tamada, S. and Kato, M. and Takeyama, Y. and Fujioka, M. and Kakehashi, A. and Nakatani, T. and Wanibuchi, H. and Gi, M.

    Exp Ther Med   16 ( 6 )   4463 - 4470   2018

     More details

    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

  • mTOR Activation in Liver Tumors Is Associated with Metabolic Syndrome and Non-Alcoholic Steatohepatitis in Both Mouse Models and Humans Reviewed

    Okuno, T. and Kakehashi, A. and Ishii, N. and Fujioka, M. and Gi, M. and Wanibuchi, H.

    Cancers (Basel)   10 ( 12 )   2018

     More details

    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

  • Chronic dietary toxicity and carcinogenicity studies of dammar resin in F344 rats Reviewed

    Gi, M. and Fujioka, M. and Yamano, S. and Kakehashi, A. and Oishi, Y. and Okuno, T. and Yukimatsu, N. and Yamaguchi, T. and Tago, Y. and Kitano, M. and Hayashi, S. M. and Wanibuchi, H.

    Arch Toxicol   92 ( 12 )   3565 - 3583   2018

     More details

    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

  • In vivo positive mutagenicity of 1,4-dioxane and quantitative analysis of its mutagenicity and carcinogenicity in rats Reviewed

    Gi, M. and Fujioka, M. and Kakehashi, A. and Okuno, T. and Masumura, K. and Nohmi, T. and Matsumoto, M. and Omori, M. and Wanibuchi, H. and Fukushima, S.

    Arch Toxicol   92 ( 10 )   3207 - 3221   2018

     More details

    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

  • Enhanced Susceptibility of Ogg1 Mutant Mice to Multiorgan Carcinogenesis.

    Kakehashi A, Ishii N, Okuno T, Fujioka M, Gi M, Wanibuchi H

    International journal of molecular sciences   18 ( 8 )   2017.08

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.3390/ijms18081801

    PubMed

  • F344ラットへのジフェニルアルシン酸含有飲料水104週間投与の発癌性に関する検討(A carcinogenicity study of diphenylarsinic acid in F344 rats in drinking water for 104 weeks)

    Yamaguchi Takashi, Gi Min, Fujioka Masaki, Doi Kenichiro, Okuno Takahiro, Kakehashi Anna, Wanibuchi Hideki

    (一社)日本毒性学会 The Journal of Toxicological Sciences   42 ( 4 )   475 - 483   2017.08( ISSN:0388-1350

     More details

    Publishing type:Research paper (scientific journal)  

    ジフェニルアルシン酸(DPAA)含有飲料水を雌雄F344ラットに104週間摂取させ、過去に52週間DPAAを投与した際に認められた肝内胆管肥厚が腫瘍に進展するか否かを含め、DPAAによる発癌性を検討した。雌雄ラットを4群に分け、飲料水中のDPAA濃度を0、5、10、20ppmの4段階に設定し、雌雄の群間で発癌性を比較した。その結果、雌性20ppm群では有意な生存率の低下を認め、雄性20ppm群と雌性10、20ppm群では有意な体重の減少を認めた。全組織における腫瘍の包括的組織病理学的検査では、雌雄ラットの全群で、どの器官にも腫瘍発生率の有意な上昇を認めなかった。以上より、DPAAは雌雄F344ラットの発癌物質ではないと考えられた。

  • 炭酸脱水酵素2は膀胱癌における新規の浸潤性関連因子である(Carbonic anhydrase 2 is a novel invasion-associated factor in urinary bladder cancers)

    Tachibana Hirokazu, Gi Min, Kato Minoru, Yamano Shotaro, Fujioka Masaki, Kakehashi Anna, Hirayama Yukiyoshi, Koyama Yuki, Tamada Satoshi, Nakatani Tatsuya, Wanibuchi Hideki

    John Wiley & Sons Australia, Ltd Cancer Science   108 ( 3 )   331 - 337   2017.03( ISSN:1347-9032

     More details

    Publishing type:Research paper (scientific journal)  

    浸潤性尿路上皮癌(UC)モデルラットを作製し、浸潤性関連因子を分析した。N-ブチル-N-(ヒドロキシブチル)ニトロソアミン(BBN)およびフェネチルイソチオシアネート(PEITC)により浸潤性UCラットを作製し、浸潤性関連蛋白を同定した。プロテオーム解析により、浸潤性UCラットと非浸潤性UCラットの蛋白質プロファイルを比較した結果、浸潤性UCラットでは過剰発現または低発現を認めるが非浸潤性UCラットではいずれも認めない49の蛋白質が同定された。免疫組織化学的分析の結果、炭酸脱水酵素2(CA2)陽性UCの数が浸潤性UCにおいて非浸潤性UCと比較して有意に多いことが示された。さらに、CA2陽性癌の発現頻度は、ヒト筋層浸潤性膀胱癌(MIBC)において筋層非浸潤性膀胱癌(NMIBC)に比べて有意に高く、NMIBCの進行と正の相関を示した。以上より、CA2は膀胱癌における浸潤関連因子であり、膀胱癌の治療標的となり得ることが示された。

  • Carbonic anhydrase 2 is a novel invasion-associated factor in urinary bladder cancers.

    Tachibana H, Gi M, Kato M, Yamano S, Fujioka M, Kakehashi A, Hirayama Y, Koyama Y, Tamada S, Nakatani T, Wanibuchi H

    Cancer science   108 ( 3 )   331 - 337   2017.03( ISSN:1347-9032

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/cas.13143

    PubMed

  • Chemopreventive Action by Ethanol-extracted Brazilian Green Propolis on Post-initiation Phase of Inflammation-associated Rat Colon Tumorigenesis.

    Doi K, Fujioka M, Sokuza Y, Ohnishi M, Gi M, Takeshita M, Kumada K, Kakehashi A, Wanibuchi H

    In vivo (Athens, Greece)   31 ( 2 )   187 - 197   2017.03( ISSN:0258-851X

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.21873/invivo.11044

    PubMed

  • ラット中期多臓器発がん性試験においてジフェニルアルシン酸は胆管癌発症に促進作用をもたらす(Diphenylarsinic acid exerts promotion effects on hepatobiliary carcinogenesis in a rat medium-term multiorgan carcinogenicity bioassay)

    Ishii Naomi, Gi Min, Fujioka Masaki, Yamano Shotaro, Okumura Mai, Kakehashi Anna, Wanibuchi Hideki

    日本毒性病理学会 Journal of Toxicologic Pathology   30 ( 1 )   39 - 45   2017.01( ISSN:0914-9198

     More details

    Publishing type:Research paper (scientific journal)  

    6週齢の雄性F344ラットを用い、ジフェニルアルシン酸(DPAA)の発癌作用について明らかにするため、多臓器発がん性試験を実施した。まず、ジエチルニトロソアミン、N-ブチル-N-(4-ヒドロキシブチル)ニトロソアミン、N-メチル-N-ニトロソウレア、N-ビス(2-ヒドロキシプロピル)ニトロソアミンおよび1、2-ジメチルヒドラジン二塩酸塩を投与した後、DPAAを5ppmもしくは20ppm濃度で添加した水を27週間与えた。次に、DPAAを20ppm与えたラット(20ppm DPAA群)とDPAAを与えなかったラット(0ppm DPAA群)に分け、中程度の胆管過形成の発症率を調べた結果、DPAA添加群が29.4%およびDPAA無添加群が0%であった。また、重度胆管過形成の発症率ではDPAA添加群が70.6%、DPAA無添加群が0%で、20ppm DAPP群および0ppm DPAA群における中程度の胆管過形成の発症率はそれぞれ29.4%および0%で、重度の胆管過形成の発症率は70.6%および0%であった。さらに、20ppm DAPP群および0ppm DPAA群における胆管腫発症率はそれぞれ29.4%および0%で、個体当りの個数はそれぞれ0.4±0.8個および0個であった。なお、20ppm DPAA群および0ppm DPAA群における肝臓の前癌病変である胎盤型グルタチオンS-トランスフェラーゼ陽性細胞巣と前癌病変の数はそれぞれ10.5±2.2/cm2および6.2±2.9/cm2で、平均面積はそれぞれ5.3±1.7mm2/cm2および2.4±1.4mm2/cm2であった。以上の所見から、DAPPは、ラットにおいて、肝臓以外に胆管癌の発症は促進させるが、他臓器の発癌は誘導しないことが示された。

  • A chronic toxicity study of diphenylarsinic acid in F344 rats in drinking water for 52 weeks.

    Yamaguchi T, Gi M, Yamano S, Fujioka M, Tatsumi K, Kawachi S, Ishii N, Doi K, Kakehashi A, Wanibuchi H

    Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie   69 ( 1 )   1 - 7   2017.01( ISSN:0940-2993

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.etp.2016.10.002

    PubMed

  • Diphenylarsinic acid exerts promotion effects on hepatobiliary carcinogenesis in a rat medium-term multiorgan carcinogenicity bioassay.

    Ishii N, Gi M, Fujioka M, Yamano S, Okumura M, Kakehashi A, Wanibuchi H

    Journal of toxicologic pathology   30 ( 1 )   39 - 45   2017.01( ISSN:0914-9198

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.1293/tox.2016-0049

    PubMed

  • Chemopreventive Action by Ethanol-extracted Brazilian Green Propolis on Post-initiation Phase of Inflammation-associated Rat Colon Tumorigenesis Reviewed

    Doi, K. and Fujioka, M. and Sokuza, Y. and Ohnishi, M. and Gi, M. and Takeshita, M. and Kumada, K. and Kakehashi, A. and Wanibuchi, H.

    In Vivo   31 ( 2 )   187 - 197   2017

     More details

    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

  • A chronic toxicity study of diphenylarsinic acid in F344 rats in drinking water for 52 weeks Reviewed

    Yamaguchi, T. and Gi, M. and Yamano, S. and Fujioka, M. and Tatsumi, K. and Kawachi, S. and Ishii, N. and Doi, K. and Kakehashi, A. and Wanibuchi, H.

    Exp Toxicol Pathol   69 ( 1 )   1 - 7   2017

     More details

    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

  • A carcinogenicity study of diphenylarsinic acid in F344 rats in drinking water for 104 weeks Reviewed

    Yamaguchi, T. and Gi, M. and Fujioka, M. and Doi, K. and Okuno, T. and Kakehashi, A. and Wanibuchi, H.

    J Toxicol Sci   42 ( 4 )   475 - 483   2017

     More details

    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

  • Carbonic anhydrase 2 is a novel invasion-associated factor in urinary bladder cancers Reviewed

    Tachibana, H. and Gi, M. and Kato, M. and Yamano, S. and Fujioka, M. and Kakehashi, A. and Hirayama, Y. and Koyama, Y. and Tamada, S. and Nakatani, T. and Wanibuchi, H.

    Cancer Sci   108 ( 3 )   331 - 337   2017

     More details

    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

  • Enhanced Susceptibility of Ogg1 Mutant Mice to Multiorgan Carcinogenesis Reviewed

    Kakehashi, A. and Ishii, N. and Okuno, T. and Fujioka, M. and Gi, M. and Wanibuchi, H.

    Int J Mol Sci   18 ( 8 )   2017

     More details

    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

  • Progression of Hepatic Adenoma to Carcinoma in Ogg1 Mutant Mice Induced by Phenobarbital Reviewed

    Kakehashi, A. and Ishii, N. and Okuno, T. and Fujioka, M. and Gi, M. and Fukushima, S. and Wanibuchi, H.

    Oxid Med Cell Longev   2017   8541064 - 8541064   2017

     More details

    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

  • Diphenylarsinic acid exerts promotion effects on hepatobiliary carcinogenesis in a rat medium-term multiorgan carcinogenicity bioassay Reviewed

    Ishii, N. and Gi, M. and Fujioka, M. and Yamano, S. and Okumura, M. and Kakehashi, A. and Wanibuchi, H.

    J Toxicol Pathol   30 ( 1 )   39 - 45   2017

     More details

    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

  • Progression of Hepatic Adenoma to Carcinoma in Ogg1 Mutant Mice Induced by Phenobarbital.

    Kakehashi A, Ishii N, Okuno T, Fujioka M, Gi M, Fukushima S, Wanibuchi H

    Oxidative medicine and cellular longevity   2017   8541064   2017( ISSN:1942-0900

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.1155/2017/8541064

    PubMed

  • A carcinogenicity study of diphenylarsinic acid in F344 rats in drinking water for 104 weeks.

    Yamaguchi T, Gi M, Fujioka M, Doi K, Okuno T, Kakehashi A, Wanibuchi H

    The Journal of toxicological sciences   42 ( 4 )   475 - 483   2017( ISSN:0388-1350

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.2131/jts.42.475

    PubMed

  • 腎細胞癌マウスモデルにおける抗PD-L1投与はエベロリムスの抗腫瘍作用を増強する(Anti-PD-L1 treatment enhances antitumor effect of everolimus in a mouse model of renal cell carcinoma)

    Hirayama Yukiyoshi, Gi Min, Yamano Shotaro, Tachibana Hirokazu, Okuno Takahiro, Tamada Satoshi, Nakatani Tatsuya, Wanibuchi Hideki

    John Wiley & Sons Australia, Ltd Cancer Science   107 ( 12 )   1736 - 1744   2016.12( ISSN:1347-9032

     More details

    Publishing type:Research paper (scientific journal)  

    mTOR阻害剤エベロリムス(EVE)と抗プログラム細胞死リガンド1(PD-L1)併用療法の有効性を評価するため、まずヒト腎細胞癌細胞株である786-Oとマウス腎細胞癌細胞株RENCAにおけるPD-L1発現に対するEVEの作用をin vitroで評価した。その結果、EVEは腎細胞癌細胞においてPD-L1の発現を亢進させることが明らかになった。さらに、マウスにEVEを投与した結果、投与後にPD-L1の発現が亢進していた。次にEVE単独、抗PD-L1単独、EVE+抗PD-L1併用の3通りの抗腫瘍効果を調べたところ、EVE単独投与では対照群に比べて腫瘍負荷の有意な軽減が見られたが、PD-L1単独投与では見られなかった。またEVE+抗PD-L1併用投与はEVE単独投与に比べて腫瘍負荷の有意な軽減がみられ、腫瘍浸潤リンパ球の増加と細胞毒性のあるCD8陽性T細胞の増加が認められた。以上から、抗PD-L1投与はEVEの抗腫瘍作用を増強することが示唆された。

  • Anti-PD-L1 treatment enhances antitumor effect of everolimus in a mouse model of renal cell carcinoma.

    Hirayama Y, Gi M, Yamano S, Tachibana H, Okuno T, Tamada S, Nakatani T, Wanibuchi H

    Cancer science   107 ( 12 )   1736 - 1744   2016.12( ISSN:1347-9032

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/cas.13099

    PubMed

  • Pueraria mirifica Exerts Estrogenic Effects in the Mammary Gland and Uterus and Promotes Mammary Carcinogenesis in Donryu Rats.

    Kakehashi A, Yoshida M, Tago Y, Ishii N, Okuno T, Gi M, Wanibuchi H

    Toxins   8 ( 11 )   2016.11

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.3390/toxins8110275

    PubMed

  • Alteration of Esophageal Microbiome by Antibiotic Treatment Does Not Affect Incidence of Rat Esophageal Adenocarcinoma.

    Sawada A, Fujiwara Y, Nagami Y, Tanaka F, Yamagami H, Tanigawa T, Shiba M, Tominaga K, Watanabe T, Gi M, Wanibuchi H, Arakawa T

    Digestive diseases and sciences   61 ( 11 )   3161 - 3168   2016.11( ISSN:0163-2116

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s10620-016-4263-6

    PubMed

  • Examination of in vivo mutagenicity of sodium arsenite and dimethylarsinic acid in gpt delta rats.

    Fujioka M, Gi M, Kawachi S, Tatsumi K, Ishii N, Doi K, Kakehashi A, Wanibuchi H

    Journal of environmental sciences (China)   49   125 - 130   2016.11( ISSN:1001-0742

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.jes.2016.07.005

    PubMed

  • 肝細胞癌を切除したC型肝炎ウイルス陽性患者において、CD44バリアント9は生存転帰を予測する腫瘍開始細胞の潜在的バイオマーカーである(CD44 variant 9 is a potential biomarker of tumor initiating cells predicting survival outcome in hepatitis C virus-positive patients with resected hepatocellular carcinoma)

    Kakehashi Anna, Ishii Naomi, Sugihara Eiji, Gi Min, Saya Hideyuki, Wanibuchi Hideki

    John Wiley & Sons Australia, Ltd Cancer Science   107 ( 5 )   609 - 618   2016.05( ISSN:1347-9032

     More details

    Publishing type:Research paper (scientific journal)  

    ヒト肝細胞癌(HCC)における癌幹細胞のマーカーを確立するため、C型肝炎ウイルス(HVC)陽性ヒトHCCおよびジエチルニトロソアミン(DEN)誘発マウス肝癌を用いた、免疫組織化学染色によるCD44バリアント9(CD44v9)発現について調査した。臨床検体には、原発性HCC患者90例(男性62例、女性28例、年齢中央値72歳、年齢範囲45〜84歳)の肝臓腫瘍検体90例を用いて検討を行った。その結果、90例中CD44v9陽性は65例に認められ、DEN処理したマウス24例中3例にHCC発症が認められた。また、ヒトHCV陽性およびマウスHCCにおいて、局所的に局在したCD44v陽性細胞を検出したところ、ヒトおよびマウスHCCのCD44v陽性領域では、Ki67およびP-p38は大部分が陰性であり、CD44v陽性はヒトおよびマウスHCCにおいて、Nrf2、p62-SQSTM1およびKeap1過剰発現との相関性が認められた。さらに、HCV陽性HCCの90例においては、CD44v9陽性は、短い全生存期間と無再発生存期間、若年(70歳以下)、HCCの低分化度、アルカリホスファターゼ高値との有意な関連性が認められた。以上の結果から、CD44v9は、肝臓TISCの新規バイオマーカーとなり、HCV陽性HCC患者の予後因子となる可能性が示唆された。

  • CD44 variant 9 is a potential biomarker of tumor initiating cells predicting survival outcome in hepatitis C virus-positive patients with resected hepatocellular carcinoma.

    Kakehashi A, Ishii N, Sugihara E, Gi M, Saya H, Wanibuchi H

    Cancer science   107 ( 5 )   609 - 18   2016.05( ISSN:1347-9032

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/cas.12908

    PubMed

  • Qualitative and quantitative approaches in the dose-response assessment of genotoxic carcinogens.

    Fukushima S, Gi M, Kakehashi A, Wanibuchi H, Matsumoto M

    Mutagenesis   31 ( 3 )   341 - 6   2016.05( ISSN:0267-8357

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/mutage/gev049

    PubMed

  • Detection of non-genotoxic hepatocarcinogens and prediction of their mechanism of action in rats using gene marker sets.

    Kanki M, Gi M, Fujioka M, Wanibuchi H

    The Journal of toxicological sciences   41 ( 2 )   281 - 92   2016.04( ISSN:0388-1350

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.2131/jts.41.281

    PubMed

  • Identification of low-abundance proteins in serum via the isolation of HSP72 complexes.

    Tanaka M, Shiota M, Nakao T, Uemura R, Nishi S, Ohkawa Y, Matsumoto M, Yamaguchi M, Osada-Oka M, Inagaki A, Takahashi K, Nakayama KI, Gi M, Izumi Y, Miura K, Iwao H

    Journal of proteomics   136   214 - 21   2016.03( ISSN:1874-3919

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.jprot.2016.01.008

    PubMed

  • Role of deltaNp63(pos)CD44v(pos) cells in the development of N-nitroso-tris-chloroethylurea-induced peripheral-type mouse lung squamous cell carcinomas.

    Yamano S, Gi M, Tago Y, Doi K, Okada S, Hirayama Y, Tachibana H, Ishii N, Fujioka M, Tatsumi K, Wanibuchi H

    Cancer science   107 ( 2 )   123 - 32   2016.02( ISSN:1347-9032

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/cas.12855

    PubMed

  • Examination of in vivo mutagenicity of sodium arsenite and dimethylarsinic acid in gpt delta rats Reviewed

    Fujioka, M. and Gi, M. and Kawachi, S. and Tatsumi, K. and Ishii, N. and Doi, K. and Kakehashi, A. and Wanibuchi, H.

    J Environ Sci (China)   49   125 - 130   2016

     More details

    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

  • Co-localization of Ki67, CD44v and deltaNp63 in the invasive front of lung squamous cell carcinoma Reviewed

    Yamano, Shotaro and Gi, Min and Tago, Yoshiyuki and Doi, Kenichiro and Okada, Satoshi and Hirayama, Yukiyoshi and Tachibana, Hirokazu and Ishii, Naomi and Fujioka, Masaki and Tatsumi, Kumiko and Wanibuchi, Hideki

    Cancer Science   107 ( 2 )   103 - 103   2016

     More details

    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

  • Role of deltaNp63(pos)CD44v(pos) cells in the development of N-nitroso-tris-chloroethylurea-induced peripheral-type mouse lung squamous cell carcinomas Reviewed

    Yamano, S. and Gi, M. and Tago, Y. and Doi, K. and Okada, S. and Hirayama, Y. and Tachibana, H. and Ishii, N. and Fujioka, M. and Tatsumi, K. and Wanibuchi, H.

    Cancer Sci   107 ( 2 )   123 - 132   2016

     More details

    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

  • Preventive Effects of Spirogyra neglecta and a Polysaccharide Extract against Dextran Sodium Sulfate Induced Colitis in Mice Reviewed

    Taya, S. and Kakehashi, A. and Wongpoomchai, R. and Gi, M. and Ishii, N. and Wanibuchi, H.

    Asian Pac J Cancer Prev   17 ( 4 )   2235 - 2245   2016

     More details

    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

  • Alteration of Esophageal Microbiome by Antibiotic Treatment Does Not Affect Incidence of Rat Esophageal Adenocarcinoma Reviewed

    Sawada, A. and Fujiwara, Y. and Nagami, Y. and Tanaka, F. and Yamagami, H. and Tanigawa, T. and Shiba, M. and Tominaga, K. and Watanabe, T. and Gi, M. and Wanibuchi, H. and Arakawa, T.

    Dig Dis Sci   61 ( 11 )   3161 - 3168   2016

     More details

    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

  • Detection of non-genotoxic hepatocarcinogens and prediction of their mechanism of action in rats using gene marker sets Reviewed

    Kanki, M. and Gi, M. and Fujioka, M. and Wanibuchi, H.

    J Toxicol Sci   41 ( 2 )   281 - 292   2016

     More details

    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

  • CD44 variant 9 is a potential biomarker of tumor initiating cells predicting survival outcome in hepatitis C virus-positive patients with resected hepatocellular carcinoma Reviewed

    Kakehashi, A. and Ishii, N. and Sugihara, E. and Gi, M. and Saya, H. and Wanibuchi, H.

    Cancer Sci   107 ( 5 )   609 - 618   2016

     More details

    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

  • Ethanol-Extracted Brazilian Propolis Exerts Protective Effects on Tumorigenesis in Wistar Hannover Rats Reviewed

    Kakehashi, A. and Ishii, N. and Fujioka, M. and Doi, K. and Gi, M. and Wanibuchi, H.

    PLoS One   11 ( 7 )   e0158654 - e0158654   2016

     More details

    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

  • Anti-PD-L1 treatment enhances antitumor effect of everolimus in a mouse model of renal cell carcinoma Reviewed

    Hirayama, Y. and Gi, M. and Yamano, S. and Tachibana, H. and Okuno, T. and Tamada, S. and Nakatani, T. and Wanibuchi, H.

    Cancer Sci   107 ( 12 )   1736 - 1744   2016

     More details

    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

  • Granular C3 Dermatosis Reviewed

    Hashimoto, T. and Tsuruta, D. and Yasukochi, A. and Imanishi, H. and Sekine, H. and Fujita, T. and Wanibuchi, H. and Gi, M. and Karpati, S. and Sitaru, C. and Zone, J. J. and Endo, D. and Abe, S. and Nishino, T. and Koji, T. and Ishii, N.

    Acta Derm Venereol   96 ( 6 )   748 - 753   2016

     More details

    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

  • Qualitative and quantitative approaches in the dose-response assessment of genotoxic carcinogens Reviewed

    Fukushima, S. and Gi, M. and Kakehashi, A. and Wanibuchi, H. and Matsumoto, M.

    Mutagenesis   31 ( 3 )   341 - 346   2016

     More details

    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

  • Ethanol-Extracted Brazilian Propolis Exerts Protective Effects on Tumorigenesis in Wistar Hannover Rats.

    Kakehashi A, Ishii N, Fujioka M, Doi K, Gi M, Wanibuchi H

    PloS one   11 ( 7 )   e0158654   2016

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.1371/journal.pone.0158654

    PubMed

  • Preventive Effects of Spirogyra neglecta and a Polysaccharide Extract against Dextran Sodium Sulfate Induced Colitis in Mice.

    Taya S, Kakehashi A, Wongpoomchai R, Gi M, Ishii N, Wanibuchi H

    Asian Pacific journal of cancer prevention : APJCP   17 ( 4 )   2235 - 45   2016( ISSN:1513-7368

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.7314/apjcp.2016.17.4.2235

    PubMed

  • Ethanol-extracted propolis enhances BBN-initiated urinary bladder carcinogenesis via non-mutagenic mechanisms in rats.

    Xie XL, Gi M, Fujioka M, Doi K, Yamano S, Tachibana H, Fang H, Kakehashi A, Wanibuchi H

    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association   83   193 - 200   2015.09( ISSN:0278-6915

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.fct.2015.06.007

    PubMed

  • Integrative analyses of miRNA and proteomics identify potential biological pathways associated with onset of pulmonary fibrosis in the bleomycin rat model.

    Fukunaga S, Kakehashi A, Sumida K, Kushida M, Asano H, Gi M, Wanibuchi H

    Toxicology and applied pharmacology   286 ( 3 )   188 - 97   2015.08( ISSN:0041-008X

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.taap.2015.04.014

    PubMed

  • Determination of Hepatotoxicity and Its Underlying Metabolic Basis of 1,2-Dichloropropane in Male Syrian Hamsters and B6C3F1 Mice.

    Gi M, Fujioka M, Yamano S, Shimomura E, Ishii N, Kakehashi A, Takeshita M, Wanibuchi H

    Toxicological sciences : an official journal of the Society of Toxicology   145 ( 1 )   196 - 208   2015.05( ISSN:1096-6080

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/toxsci/kfv045

    PubMed

  • Integrative analyses of miRNA and proteomics identify potential biological pathways associated with onset of pulmonary fibrosis in the bleomycin rat model Reviewed

    Fukunaga, S. and Kakehashi, A. and Sumida, K. and Kushida, M. and Asano, H. and Gi, M. and Wanibuchi, H.

    Toxicol Appl Pharmacol   286 ( 3 )   188 - 197   2015

     More details

    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

  • Ethanol-extracted propolis enhances BBN-initiated urinary bladder carcinogenesis via non-mutagenic mechanisms in rats Reviewed

    Xie, X. L. and Gi, M. and Fujioka, M. and Doi, K. and Yamano, S. and Tachibana, H. and Fang, H. and Kakehashi, A. and Wanibuchi, H.

    Food Chem Toxicol   83   193 - 200   2015

     More details

    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

  • Paraneoplastic Ma Antigen-Like 1 as a Potential Prognostic Biomarker in Human Pancreatic Ductal Adenocarcinoma Reviewed

    Kuwae, Y. and Kakehashi, A. and Wakasa, K. and Wei, M. and Yamano, S. and Ishii, N. and Ohsawa, M. and Wanibuchi, H.

    Pancreas   44 ( 1 )   106 - 115   2015

     More details

    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

  • Roles of Leucine and Isoleucine in Experimental Models of Bladder Carcinogenesis Reviewed

    Gi, Min and Wanibuchi, Hideki

    Food Safety   3 ( 4 )   136 - 142   2015

     More details

    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

  • Modifying effects of 1,2-dichloropropane on N-nitrosobis(2-oxopropyl)amine-induced cholangiocarcinogenesis in male Syrian hamsters Reviewed

    Gi, M. and Fujioka, M. and Yamano, S. and Shimomura, E. and Kanki, M. and Kawachi, S. and Tachibana, H. and Tatsumi, K. and Fang, H. and Ishii, N. and Kakehashi, A. and Wanibuchi, H.

    J Toxicol Sci   40 ( 5 )   647 - 656   2015

     More details

    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

  • Determination of Hepatotoxicity and Its Underlying Metabolic Basis of 1,2-Dichloropropane in Male Syrian Hamsters and B6C3F1 Mice Reviewed

    Gi, M. and Fujioka, M. and Yamano, S. and Shimomura, E. and Ishii, N. and Kakehashi, A. and Takeshita, M. and Wanibuchi, H.

    Toxicol Sci   145 ( 1 )   196 - 208   2015

     More details

    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

  • Modifying effects of 1,2-dichloropropane on N-nitrosobis(2-oxopropyl)amine-induced cholangiocarcinogenesis in male Syrian hamsters.

    Gi M, Fujioka M, Yamano S, Shimomura E, Kanki M, Kawachi S, Tachibana H, Tatsumi K, Fang H, Ishii N, Kakehashi A, Wanibuchi H

    The Journal of toxicological sciences   40 ( 5 )   647 - 56   2015( ISSN:0388-1350

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.2131/jts.40.647

    PubMed

  • Threshold of Genotoxic Carcinogens: Consideration from No-Effect Doses for Cancer-Related Markers in Chemical Carcinogenesis

    Fukushima Shoji, Gi Min, Kakehashi Anna, Wanibuchi Hideki

    MUTAGENESIS   29 ( 6 )   554 - 554   2014.11( ISSN:0267-8357

     More details

    Publishing type:Research paper (scientific journal)  

  • Valerian inhibits rat hepatocarcinogenesis by activating GABA(A) receptor-mediated signaling Reviewed

    Kakehashi, A. and Kato, A. and Ishii, N. and Wei, M. and Morimura, K. and Fukushima, S. and Wanibuchi, H.

    PLoS One   9 ( 11 )   e113610 - e113610   2014

     More details

    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

  • Inhibitory effect of Raphanobrassica on Helicobacter pylori-induced gastritis in Mongolian gerbils Reviewed

    Yamada, T. and Wei, M. and Toyoda, T. and Yamano, S. and Wanibuchi, H.

    Food Chem Toxicol   70   107 - 113   2014

     More details

    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

  • Genotoxicity and subacute toxicity studies of a new astaxanthin-containing Phaffia rhodozyma extract Reviewed

    Tago, Y. and Fujii, T. and Wada, J. and Kato, M. and Wei, M. and Wanibuchi, H. and Kitano, M.

    J Toxicol Sci   39 ( 3 )   373 - 382   2014

     More details

    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

  • Lipid synthesis is promoted by hypoxic adipocyte-derived exosomes in 3T3-L1 cells Reviewed

    Sano, S. and Izumi, Y. and Yamaguchi, T. and Yamazaki, T. and Tanaka, M. and Shiota, M. and Osada-Oka, M. and Nakamura, Y. and Wei, M. and Wanibuchi, H. and Iwao, H. and Yoshiyama, M.

    Biochem Biophys Res Commun   445 ( 2 )   327 - 333   2014

     More details

    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

  • Mode of action of ethyl tertiary-butyl ether hepatotumorigenicity in the rat: evidence for a role of oxidative stress via activation of CAR, PXR and PPAR signaling pathways Reviewed

    Kakehashi, A. and Hagiwara, A. and Imai, N. and Nagano, K. and Nishimaki, F. and Banton, M. and Wei, M. and Fukushima, S. and Wanibuchi, H.

    Toxicol Appl Pharmacol   273 ( 2 )   390 - 400   2013

     More details

    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

  • Clinicopathological significance of combined analysis of cytokeratin19 expression and preoperative serum CYFRA21-1 levels in human lung squamous cell carcinoma Reviewed

    Hanada, S. and Nishiyama, N. and Mizuguchi, S. and Yamano, S. and Kakehashi, A. and Wei, M. and Inoue, H. and Komatsu, H. and Chung, K. and Suehiro, S. and Wanibuchi, H.

    Osaka City Med J   59 ( 1 )   35 - 44   2013

     More details

    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

  • Myristoylated alanine-rich C-kinase substrate as a prognostic biomarker in human primary lung squamous cell carcinoma Reviewed

    Hanada, S. and Kakehashi, A. and Nishiyama, N. and Wei, M. and Yamano, S. and Chung, K. and Komatsu, H. and Inoue, H. and Suehiro, S. and Wanibuchi, H.

    Cancer Biomark   13 ( 4 )   289 - 298   2013

     More details

    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

  • L-Leucine and L-isoleucine enhance growth of BBN-induced urothelial tumors in the rat bladder by modulating expression of amino acid transporters and tumorigenesis-associated genes Reviewed

    Xie, X. L. and Kakehashi, A. and Wei, M. and Yamano, S. and Takeshita, M. and Yunoki, T. and Wanibuchi, H.

    Food Chem Toxicol   59   137 - 144   2013

     More details

    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

  • Diphenylarsinic acid, a chemical warfare-related neurotoxicant, promotes liver carcinogenesis via activation of aryl hydrocarbon receptor signaling and consequent induction of oxidative DNA damage in rats Reviewed

    Wei, M. and Yamada, T. and Yamano, S. and Kato, M. and Kakehashi, A. and Fujioka, M. and Tago, Y. and Kitano, M. and Wanibuchi, H.

    Toxicol Appl Pharmacol   273 ( 1 )   1 - 9   2013

     More details

    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

  • Novel medium-term carcinogenesis model for lung squamous cell carcinoma induced by N-nitroso-tris-chloroethylurea in mice Reviewed

    Tago, Y. and Yamano, S. and Wei, M. and Kakehashi, A. and Kitano, M. and Fujioka, M. and Ishii, N. and Wanibuchi, H.

    Cancer Sci   104 ( 12 )   1560 - 1566   2013

     More details

    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

  • Complexin-2 (CPLX2) as a potential prognostic biomarker in human lung high grade neuroendocrine tumors Reviewed

    Komatsu, H. and Kakehashi, A. and Nishiyama, N. and Izumi, N. and Mizuguchi, S. and Yamano, S. and Inoue, H. and Hanada, S. and Chung, K. and Wei, M. and Suehiro, S. and Wanibuchi, H.

    Cancer Biomark   13 ( 3 )   171 - 180   2013

     More details

    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

  • Evaluation of the modifying effect of inhalation of mainstream cigarette smoke on mouse bladder carcinogenesis Reviewed

    Kato, M. and Wei, M. and Yamano, S. and Fujioka, M. and Kakehashi, A. and Wanibuchi, H.

    J Toxicol Pathol   26 ( 4 )   447 - 451   2013

     More details

    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

  • Oxidative stress in the carcinogenicity of chemical carcinogens Reviewed

    Kakehashi, A. and Wei, M. and Fukushima, S. and Wanibuchi, H.

    Cancers (Basel)   5 ( 4 )   1332 - 1354   2013

     More details

    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

  • AGR2 as a potential biomarker of human lung adenocarcinoma Reviewed

    Chung, K. and Nishiyama, N. and Wanibuchi, H. and Yamano, S. and Hanada, S. and Wei, M. and Suehiro, S. and Kakehashi, A.

    Osaka City Med J   58 ( 1 )   13 - 24   2012

     More details

    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

  • Long-term treatment with L-isoleucine or L-leucine in AIN-93G diet has promoting effects on rat bladder carcinogenesis Reviewed

    Xie, X. L. and Wei, M. and Yunoki, T. and Kakehashi, A. and Yamano, S. and Kato, M. and Wanibuchi, H.

    Food Chem Toxicol   50 ( 11 )   3934 - 3940   2012

     More details

    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

  • 2-Amino-3-methylimidazo[4,5-f]quinoline (IQ) promotes mouse hepatocarcinogenesis by activating transforming growth factor-beta and Wnt/beta-catenin signaling pathways Reviewed

    Xie, X. L. and Wei, M. and Kakehashi, A. and Yamano, S. and Tajiri, M. and Wanibuchi, H.

    Toxicol Sci   125 ( 2 )   392 - 400   2012

     More details

    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

  • Dammar resin, a non-mutagen, induces [corrected] oxidative stress and metabolic enzymes in the liver of gpt delta transgenic mouse which is different from a mutagen, 2-amino-3-methylimidazo[4,5-f]quinoline Reviewed

    Xie, X. L. and Wei, M. and Kakehashi, A. and Yamano, S. and Okabe, K. and Tajiri, M. and Wanibuchi, H.

    Mutat Res   748 ( 1-2 )   29 - 35   2012

     More details

    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

  • Lack of Hepatocarcinogenicity of Combinations of Low Doses of 2-amino-3, 8-dimethylimidazo[4,5- f ]quinoxaline and Diethylnitrosamine in Rats: Indication for the Existence of a Threshold for Genotoxic Carcinogens Reviewed

    Wei, M. and Kakehashi, A. and Yamano, S. and Tamano, S. and Shirai, T. and Wanibuchi, H. and Fukushima, S.

    J Toxicol Pathol   25 ( 3 )   209 - 214   2012

     More details

    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

  • Proteome analysis of laser microdissected glomeruli from formalin-fixed paraffin-embedded kidneys of autopsies of diabetic patients: nephronectin is associated with the development of diabetic glomerulosclerosis Reviewed

    Nakatani, S. and Wei, M. and Ishimura, E. and Kakehashi, A. and Mori, K. and Nishizawa, Y. and Inaba, M. and Wanibuchi, H.

    Nephrol Dial Transplant   27 ( 5 )   1889 - 1897   2012

     More details

    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

  • DDX39 acts as a suppressor of invasion for bladder cancer Reviewed

    Kato, M. and Wei, M. and Yamano, S. and Kakehashi, A. and Tamada, S. and Nakatani, T. and Wanibuchi, H.

    Cancer Sci   103 ( 7 )   1363 - 1369   2012

     More details

    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

  • Hormonally active doses of isoflavone aglycones promote mammary and endometrial carcinogenesis and alter the molecular tumor environment in Donryu rats Reviewed

    Kakehashi, A. and Tago, Y. and Yoshida, M. and Sokuza, Y. and Wei, M. and Fukushima, S. and Wanibuchi, H.

    Toxicol Sci   126 ( 1 )   39 - 51   2012

     More details

    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

  • Serum AGR2 as an early diagnostic and postoperative prognostic biomarker of human lung adenocarcinoma Reviewed

    Chung, K. and Nishiyama, N. and Yamano, S. and Komatsu, H. and Hanada, S. and Wei, M. and Wanibuchi, H. and Suehiro, S. and Kakehashi, A.

    Cancer Biomark   10 ( 2 )   101 - 107   2011

     More details

    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

  • Low-dose carcinogenicity of 2-amino-3-methylimidazo[4,5-f ]quinoline in rats: Evidence for the existence of no-effect levels and a mechanism involving p21(Cip / WAF1) Reviewed

    Wei, M. and Wanibuchi, H. and Nakae, D. and Tsuda, H. and Takahashi, S. and Hirose, M. and Totsuka, Y. and Tatematsu, M. and Fukushima, S.

    Cancer Sci   102 ( 1 )   88 - 94   2011

     More details

    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

  • Targeted proteomics of isolated glomeruli from the kidneys of diabetic rats: sorbin and SH3 domain containing 2 is a novel protein associated with diabetic nephropathy Reviewed

    Nakatani, S. and Kakehashi, A. and Ishimura, E. and Yamano, S. and Mori, K. and Wei, M. and Inaba, M. and Wanibuchi, H.

    Exp Diabetes Res   2011   979354 - 979354   2011

     More details

    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

  • Role of Th-2 cytokines in the development of Barrett's esophagus in rats Reviewed

    Kohata, Y. and Fujiwara, Y. and Machida, H. and Okazaki, H. and Yamagami, H. and Tanigawa, T. and Watanabe, K. and Watanabe, T. and Tominaga, K. and Wei, M. and Wanibuchi, H. and Arakawa, T.

    J Gastroenterol   46 ( 7 )   883 - 893   2011

     More details

    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

  • Mitochondrial prohibitins and septin 9 are implicated in the onset of rat hepatocarcinogenesis Reviewed

    Kakehashi, A. and Ishii, N. and Shibata, T. and Wei, M. and Okazaki, E. and Tachibana, T. and Fukushima, S. and Wanibuchi, H.

    Toxicol Sci   119 ( 1 )   61 - 72   2011

     More details

    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

  • Enhanced Urinary Bladder, Liver and Colon Carcinogenesis in Zucker Diabetic Fatty Rats in a Multiorgan Carcinogenesis Bioassay: Evidence for Mechanisms Involving Activation of PI3K Signaling and Impairment of p53 on Urinary Bladder Carcinogenesis Reviewed

    Ishii, N. and Wei, M. and Kakehashi, A. and Doi, K. and Yamano, S. and Inaba, M. and Wanibuchi, H.

    J Toxicol Pathol   24 ( 1 )   25 - 36   2011

     More details

    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

  • Tumor-associated MUC5AC stimulates in vivo tumorigenicity of human pancreatic cancer Reviewed

    Hoshi, H. and Sawada, T. and Uchida, M. and Saito, H. and Iijima, H. and Toda-Agetsuma, M. and Wada, T. and Yamazoe, S. and Tanaka, H. and Kimura, K. and Kakehashi, A. and Wei, M. and Hirakawa, K. and Wanibuchi, H.

    Int J Oncol   38 ( 3 )   619 - 627   2011

     More details

    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

  • Non-genotoxic mode of action and possible threshold for hepatocarcinogenicity of Kojic acid in F344 rats Reviewed

    Chusiri, Y. and Wongpoomchai, R. and Kakehashi, A. and Wei, M. and Wanibuchi, H. and Vinitketkumnuan, U. and Fukushima, S.

    Food Chem Toxicol   49 ( 2 )   471 - 476   2011

     More details

    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

  • Chemopreventive effects of 13alpha,14alpha-epoxy-3beta-methoxyserratan-21beta-ol (PJJ-34), a serratane-type triterpenoid, in a rat multi-organ carcinogenesis bioassay Reviewed

    Doi, K. and Sakai, K. and Tanaka, R. and Toma, K. and Yamaguchi, T. and Wei, M. and Fukushima, S. and Wanibuchi, H.

    Cancer Lett   289 ( 2 )   161 - 169   2010

     More details

    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

  • Evaluation of the Subchronic Toxicity of Dietary Administered Equisetum arvense in F344 Rats Reviewed

    Tago, Y. and Wei, M. and Ishii, N. and Kakehashi, A. and Wanibuchi, H.

    J Toxicol Pathol   23 ( 4 )   245 - 251   2010

     More details

    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

  • Effects of pioglitazone, a peroxisome proliferator-activated receptor gamma agonist, on the urine and urothelium of the rat Reviewed

    Suzuki, S. and Arnold, L. L. and Pennington, K. L. and Kakiuchi-Kiyota, S. and Wei, M. and Wanibuchi, H. and Cohen, S. M.

    Toxicol Sci   113 ( 2 )   349 - 357   2010

     More details

    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

  • Cytokeratin 8/18 as a new marker of mouse liver preneoplastic lesions Reviewed

    Kakehashi, A. and Kato, A. and Inoue, M. and Ishii, N. and Okazaki, E. and Wei, M. and Tachibana, T. and Wanibuchi, H.

    Toxicol Appl Pharmacol   242 ( 1 )   47 - 55   2010

     More details

    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

  • Enhancement of preneoplastic lesion yield by Chios Mastic Gum in a rat liver medium-term carcinogenesis bioassay Reviewed

    Doi, K. and Wei, M. and Kitano, M. and Uematsu, N. and Inoue, M. and Wanibuchi, H.

    Toxicol Appl Pharmacol   234 ( 1 )   135 - 142   2009

     More details

    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

  • Potassium bromate enhances N-ethyl-N-hydroxyethylnitrosamine-induced kidney carcinogenesis only at high doses in Wistar rats: indication of the existence of an enhancement threshold Reviewed

    Wei, M. and Hamoud, A. S. and Yamaguchi, T. and Kakehashi, A. and Morimura, K. and Doi, K. and Kushida, M. and Kitano, M. and Wanibuchi, H. and Fukushima, S.

    Toxicol Pathol   37 ( 7 )   983 - 991   2009

     More details

    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

  • Increased susceptibility to spontaneous lung cancer in mice lacking LIM-domain only 7 Reviewed

    Tanaka-Okamoto, M. and Hori, K. and Ishizaki, H. and Hosoi, A. and Itoh, Y. and Wei, M. and Wanibuchi, H. and Mizoguchi, A. and Nakamura, H. and Miyoshi, J.

    Cancer Sci   100 ( 4 )   608 - 616   2009

     More details

    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

  • Urinary bladder carcinogenesis induced by chronic exposure to persistent low-dose ionizing radiation after Chernobyl accident Reviewed

    Romanenko, A. and Kakehashi, A. and Morimura, K. and Wanibuchi, H. and Wei, M. and Vozianov, A. and Fukushima, S.

    Carcinogenesis   30 ( 11 )   1821 - 1831   2009

     More details

    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

  • Ethanol Does Not Promote MeIQx-initiated Rat Colon Carcinogenesis Based on Evidence from Analysis of a Colon Cancer Surrogate Marker Reviewed

    Kushida, M. and Wanibuchi, H. and Wei, M. and Kakehashi, A. and Ozaki, K. and Sukata, T. and Miyata, K. and Ogata, K. and Uwagawa, S. and Fukushima, S.

    J Toxicol Pathol   22 ( 1 )   65 - 70   2009

     More details

    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

  • Cytokeratin 8/18 overexpression and complex formation as an indicator of GST-P positive foci transformation into hepatocellular carcinomas Reviewed

    Kakehashi, A. and Inoue, M. and Wei, M. and Fukushima, S. and Wanibuchi, H.

    Toxicol Appl Pharmacol   238 ( 1 )   71 - 79   2009

     More details

    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

  • Lack of mutagenic and toxic effects of low dose potassium bromate on kidneys in the Big Blue rat Reviewed

    Yamaguchi, T. and Wei, M. and Hagihara, N. and Omori, M. and Wanibuchi, H. and Fukushima, S.

    Mutat Res   652 ( 1 )   1 - 11   2008

     More details

    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

  • Cytotoxicity of combinations of arsenicals on rat urinary bladder urothelial cells in vitro Reviewed

    Nascimento, M. G. and Suzuki, S. and Wei, M. and Tiwari, A. and Arnold, L. L. and Lu, X. and Le, X. C. and Cohen, S. M.

    Toxicology   249 ( 1 )   69 - 74   2008

     More details

    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

  • Altered gene expression in rat colonic adenocarcinomas induced in an azoxymethane plus 2-amino-1-methyl-6-phenylimidazo[4,5-b]- pyridine initiation-promotion model Reviewed

    Doi, K. and Hagihara, A. and Wei, M. and Yunoki, T. and Fukushima, S. and Wanibuchi, H.

    Oncology   73 ( 3-4 )   252 - 260   2007

     More details

    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

  • Elevation of 8-hydroxydeoxyguanosine and cell proliferation via generation of oxidative stress by organic arsenicals contributes to their carcinogenicity in the rat liver and bladder Reviewed

    Kinoshita, A. and Wanibuchi, H. and Wei, M. and Yunoki, T. and Fukushima, S.

    Toxicol Appl Pharmacol   221 ( 3 )   295 - 305   2007

     More details

    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

  • Carcinogenicity of dimethylarsinic acid in Ogg1-deficient mice Reviewed

    Kinoshita, A. and Wanibuchi, H. and Morimura, K. and Wei, M. and Nakae, D. and Arai, T. and Minowa, O. and Noda, T. and Nishimura, S. and Fukushima, S.

    Cancer Sci   98 ( 6 )   803 - 814   2007

     More details

    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

  • High sensitivity of fatty liver Shionogi (FLS) mice to diethylnitrosamine hepatocarcinogenesis: comparison to C3H and C57 mice Reviewed

    Iwai, S. and Murai, T. and Makino, S. and Wei, M. and Morimura, K. and Mori, S. and Hagihara, A. and Seki, S. and Fukushima, S.

    Cancer Lett   246 ( 1-2 )   115 - 121   2007

     More details

    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

  • [Development of invasive urinary bladder carcinomas] Reviewed

    Fukushima, S. and Wanibuchi, H. and Wei, M. and Morimura, K.

    Hinyokika Kiyo   52 ( 6 )   451 - 455   2006

     More details

    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

  • Existence of no-observed effect levels for 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline on hepatic preneoplastic lesion development in BN rats Reviewed

    Wei, M. and Hori, T. A. and Ichihara, T. and Wanibuchi, H. and Morimura, K. and Kang, J. S. and Puatanachokchai, R. and Fukushima, S.

    Cancer Lett   231 ( 2 )   304 - 308   2006

     More details

    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

  • Effects of cessation of alcohol exposure on rat hepatocarcinogenesis Reviewed

    Wanibuchi, H. and Zhang, Y. and Kinoshita, A. and Wei, M. and Kang, J. S. and Fukushima, S.

    Asian Pac J Cancer Prev   7 ( 1 )   122 - 126   2006

     More details

    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

  • Inhibition of rat urinary bladder carcinogenesis by the antiangiogenic drug TNP-470 Reviewed

    Wanibuchi, H. and Wei, M. and Salim, E. I. and Kinoshita, A. and Morimura, K. and Sudo, K. and Fukushima, S.

    Asian Pac J Cancer Prev   7 ( 1 )   101 - 107   2006

     More details

    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

  • Existence of no hepatocarcinogenic effect levels of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline with or without coadministration with ethanol Reviewed

    Wanibuchi, H. and Wei, M. and Karim, M. R. and Morimura, K. and Doi, K. and Kinoshita, A. and Fukushima, S.

    Toxicol Pathol   34 ( 3 )   232 - 236   2006

     More details

    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

  • Involvement of ubiquitination and sumoylation in bladder lesions induced by persistent long-term low dose ionizing radiation in humans Reviewed

    Romanenko, A. M. and Kinoshita, A. and Wanibuchi, H. and Wei, M. and Zaparin, W. K. and Vinnichenko, W. I. and Vozianov, A. F. and Fukushima, S.

    J Urol   175 ( 2 )   739 - 743   2006

     More details

    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

  • Absence of beta-catenin alteration in hepatic tumors induced by p-nitroanisole in Crj:BDF1 mice Reviewed

    Kushida, M. and Aiso, S. and Morimura, K. and Wei, M. and Wanibuchi, H. and Nagano, K. and Fukushima, S.

    Toxicol Pathol   34 ( 3 )   237 - 242   2006

     More details

    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

  • Testicular toxicity of DEHP, but not DEHA, is elevated under conditions of thioacetamide-induced liver damage Reviewed

    Kang, J. S. and Morimura, K. and Toda, C. and Wanibuchi, H. and Wei, M. and Kojima, N. and Fukushima, S.

    Reprod Toxicol   21 ( 3 )   253 - 259   2006

     More details

    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

  • Are there thresholds of genotoxic carcinogens?

    Fukushima Shoji, Wanibuchi Hideki, Morimura Keiichirou, Wei Min

    The Environmental Mutagen Society of Japan, Environmental Mutagen Research   27 ( 2 )   75 - 79   2005.07( ISSN:09100865

     More details

    Publishing type:Research paper (scientific journal)  

    Until recently it has been generally considered that genotoxic carcinogens have no threshold in exerting their potential for cancer induction. However, the non-threshold theory can be challenged with regard to assessment of cancer risk to humans. In the present study we show that food-related genotoxic hepatocarcinogens, heterocyclic amines and N-nitroso compounds at low doses do not induce preneoplastic lesions and cancer-related markers in rat medium-term carcinogenicity bioassay. The results imply existence of a threshold, at least practical one, for carcinogenicities of genotoxic carcinogens.

    CiNii Article

  • Are there thresholds of genotoxic carcinogens? Reviewed

    Fukushima, Shoji and Wanibuchi, Hideki and Morimura, Keiichirou and Wei, Min

    Environmental Mutagen Research   27 ( 2 )   75 - 79   2005

     More details

    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

  • Are there thresholds for carcinogenicity on genotoxic carcinogens?

    FUKUSHIMA Shoji, WANIBUCHI Hideki, MORIMURA Keiichirou, WEI Min

    ChemoBio Integrated Management Society, ChemoBio Integrated Management   1 ( 1 )   10 - 17   2005

     More details

    Publishing type:Research paper (scientific journal)  

    Until recently it has been generally considered that genotoxic carcinogens have no threshold in exerting their potential for cancer induction. However, the non-threshold theory can be challenged with regard to assessment of cancer risk to humans. In the present study we show that food-related genotoxic hepatocarcinogens, heterocyclic amines and N-nitroso compounds at low doses do not induce preneoplastic lesions and cancer-related markers in rat medium-term carcinogenicity bioassay. The results imply existence of a threshold, at least practical one, for carcinogenicity of genotoxic carcinogens.

    DOI: 10.11171/chemobio.1.10

    CiNii Article

  • JTE-522, a selective cyclooxygenase-2 inhibitor, inhibits induction but not growth and invasion of 1,2-dimethylhydrazine-induced tubular adenocarcinomas of colon in rats Reviewed

    Wei, M. and Morimura, K. and Wanibuchi, H. and Shen, J. and Salim, E. I. and Moku, M. and Hakoi, K. and Fukushima, S.

    Int J Cancer   113 ( 3 )   354 - 358   2005

     More details

    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

  • Effects of co-administration of antioxidants and arsenicals on the rat urinary bladder epithelium Reviewed

    Wei, M. and Arnold, L. and Cano, M. and Cohen, S. M.

    Toxicol Sci   83 ( 2 )   237 - 245   2005

     More details

    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

  • Lack of urinary bladder carcinogenicity of sodium L-ascorbate in human c-Ha-ras proto-oncogene transgenic rats Reviewed

    Morimura, K. and Kang, J. S. and Wei, M. and Wanibuchi, H. and Tsuda, H. and Fukushima, S.

    Toxicol Pathol   33 ( 7 )   764 - 767   2005

     More details

    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

  • Dose-dependence of promotion of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline-induced rat hepatocarcinogenesis by ethanol: evidence for a threshold Reviewed

    Kushida, M. and Wanibuchi, H. and Morimura, K. and Kinoshita, A. and Kang, J. S. and Puatanachokchai, R. and Wei, M. and Funae, Y. and Fukushima, S.

    Cancer Sci   96 ( 11 )   747 - 757   2005

     More details

    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

  • Are there thresholds for carcinogenicity on genotoxic carcinogens? Reviewed

    Fukushima, Shoji and Wanibuchi, Hideki and Morimura, Keiichirou and Wei, Min

    ChemoBio Integrated Management   1 ( 1 )   10 - 17   2005

     More details

    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

  • Revised rat multi-organ carcinogenesis bioassay for whole-body detection of chemopreventive agents: modifying potential of S-methylcysteine Reviewed

    Doi, K. and Wanibuchi, H. and Salim, E. I. and Shen, J. and Wei, M. and Mitsuhashi, M. and Kudoh, S. and Hirata, K. and Fukushima, S.

    Cancer Lett   206 ( 1 )   15 - 26   2004

     More details

    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

  • Lack of preventive efficacy of FK228, a histone deacetylase inhibitor, against N-butyl-N-(4-hydroxybutyl) nitrosamine-induced urinary bladder carcinogenesis in p53+/- and p53+/+ mice Reviewed

    Wei, M. and Wanibuchi, H. and Morimura, K. and Salim, E. I. and Moku, M. and Doi, K. and Mitsuhashi, M. and Masuda, C. and Shen, J. and Kinoshita, A. and Fukushima, S.

    Anticancer Res   24 ( 2B )   785 - 790   2004

     More details

    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

  • Understanding arsenic carcinogenicity by the use of animal models Reviewed

    Wanibuchi, H. and Salim, E. I. and Kinoshita, A. and Shen, J. and Wei, M. and Morimura, K. and Yoshida, K. and Kuroda, K. and Endo, G. and Fukushima, S.

    Toxicol Appl Pharmacol   198 ( 3 )   366 - 376   2004

     More details

    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

  • Inhibition of azoxymethane-induced colon carcinogenesis in rats due to JTE-522, a selective cyclooxygenase-2 inhibitor Reviewed

    Shen, J. and Wanibuchi, H. and Salim, E. I. and Wei, M. and Yamachika, T. and Fukushima, S.

    Asian Pac J Cancer Prev   5 ( 3 )   253 - 258   2004

     More details

    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

  • Possible distinct molecular carcinogenic pathways for bladder cancer in Ukraine, before and after the Chernobyl disaster Reviewed

    Morimura, K. and Romanenko, A. and Wei, M. and Salim, E. I. and Kinoshita, A. and Wanibuchi, H. and Vozianov, A. and Fukushima, S.

    Oncol Rep   11 ( 4 )   881 - 886   2004

     More details

    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

  • Induction of DNA-adducts and increase of 8-hydroxy-2-deoxyguanosine, but no development of preneoplastic lesions in offspring liver with transplacental and trans-breast milk exposure to 2-amino-3,8-dimethylimidazo [4,5-f ]quinoxaline (MeIQx) in rats Reviewed

    Ichihara, T. and Wanibuchi, H. and Totsuka, Y. and Morimura, K. and Wei, M. and Nakae, D. and Fukushima, S.

    Cancer Sci   95 ( 12 )   943 - 948   2004

     More details

    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

  • Carcinogenic Potential of 2-Amino-3-methylimidazo[4,5-<i>f</i>]quinoline (IQ) in Severe Combined Immunodeficient (SCID) Mice Reviewed

    Hoshi, Manabu and Wanibuchi, Hideki and Salim, Elsayed I. and Morimura, Keiichirou and Murai, Takashi and Nomura, Taisei and Takaoka, Kunio and Fukushima, Shoji

    Journal of Toxicologic Pathology   17 ( 1 )   17 - 23   2004

     More details

    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

  • No-observed effect levels for carcinogenicity and for in vivo mutagenicity of a genotoxic carcinogen Reviewed

    Hoshi, M. and Morimura, K. and Wanibuchi, H. and Wei, M. and Okochi, E. and Ushijima, T. and Takaoka, K. and Fukushima, S.

    Toxicol Sci   81 ( 2 )   273 - 279   2004

     More details

    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

  • Lack of initiation activity in rat liver of low doses of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline Reviewed

    Fukushima, S. and Wanibuchi, H. and Morimura, K. and Wei, M. and Nakae, D. and Konishi, Y. and Tsuda, H. and Takasuka, N. and Imaida, K. and Shirai, T. and Tatematsu, M. and Tsukamoto, T. and Hirose, M. and Furukawa, F.

    Cancer Lett   191 ( 1 )   35 - 40   2003

     More details

    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

  • Chemopreventive effect of JTE-522, a selective cyclooxygenase-2 inhibitor, on 1, 2-dimethylhydrazine-induced rat colon carcinogenesis Reviewed

    Wei, M. and Morimura, K. and Wanibuchi, H. and Shen, J. and Doi, K. and Mitsuhashi, M. and Moku, M. and Salim, E. I. and Fukushima, S.

    Cancer Lett   202 ( 1 )   11 - 16   2003

     More details

    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

  • Liver tumorigenicity of trimethylarsine oxide in male Fischer 344 rats--association with oxidative DNA damage and enhanced cell proliferation Reviewed

    Shen, J. and Wanibuchi, H. and Salim, E. I. and Wei, M. and Kinoshita, A. and Yoshida, K. and Endo, G. and Fukushima, S.

    Carcinogenesis   24 ( 11 )   1827 - 1835   2003

     More details

    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

  • Induction of glutathione S-transferase placental form positive foci in liver and epithelial hyperplasia in urinary bladder, but no tumor development in male Fischer 344 rats treated with monomethylarsonic acid for 104 weeks Reviewed

    Shen, J. and Wanibuchi, H. and Salim, E. I. and Wei, M. and Doi, K. and Yoshida, K. and Endo, G. and Morimura, K. and Fukushima, S.

    Toxicol Appl Pharmacol   193 ( 3 )   335 - 345   2003

     More details

    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

  • Enhancement of lung carcinogenesis by nonylphenol and genistein in a F344 rat multiorgan carcinogenesis model Reviewed

    Seike, N. and Wanibuchi, H. and Morimura, K. and Wei, M. and Nishikawa, T. and Hirata, K. and Yoshikawa, J. and Fukushima, S.

    Cancer Lett   192 ( 1 )   25 - 36   2003

     More details

    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

  • Carcinogenicity of dimethylarsinic acid in p53 heterozygous knockout and wild-type C57BL/6J mice Reviewed

    Salim, E. I. and Wanibuchi, H. and Morimura, K. and Wei, M. and Mitsuhashi, M. and Yoshida, K. and Endo, G. and Fukushima, S.

    Carcinogenesis   24 ( 2 )   335 - 342   2003

     More details

    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

  • Urinary bladder lesions induced by persistent chronic low-dose ionizing radiation Reviewed

    Romanenko, A. and Morimura, K. and Wanibuchi, H. and Wei, M. and Zaparin, W. and Vinnichenko, W. and Kinoshita, A. and Vozianov, A. and Fukushima, S.

    Cancer Sci   94 ( 4 )   328 - 333   2003

     More details

    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

  • No inhibition of urinary bladder carcinogenesis in rats with intravesical instillation of alpha-galactosylceramide Reviewed

    Mitsuhashi, M. and Wanibuchi, H. and Wei, M. and Doi, K. and Morimura, K. and Masuda, C. and Wada, S. and Nakatani, T. and Kakizoe, T. and Fukushima, S.

    Asian Pac J Cancer Prev   4 ( 1 )   45 - 50   2003

     More details

    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

  • Significance of overexpression of metallothionein in mouse urinary bladder focal lesions induced by treatment with N-butyl-N-(4-hydroxybutyl)-nitrosamine Reviewed

    Mitsuhashi, M. and Wanibuchi, H. and Morimura, K. and Doi, K. and Wei, M. and Wada, S. and Nakatani, T. and Fukushima, S.

    Cancer Sci   94 ( 12 )   1052 - 1058   2003

     More details

    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

  • Phenobarbital at low dose exerts hormesis in rat hepatocarcinogenesis by reducing oxidative DNA damage, altering cell proliferation, apoptosis and gene expression Reviewed

    Kinoshita, A. and Wanibuchi, H. and Morimura, K. and Wei, M. and Shen, J. and Imaoka, S. and Funae, Y. and Fukushima, S.

    Carcinogenesis   24 ( 8 )   1389 - 1399   2003

     More details

    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

  • Enhancing risk of ethanol on MeIQx-induced rat hepatocarcinogenesis is accompanied with increased levels of cellular proliferation and oxidative stress Reviewed

    Karim, M. R. and Wanibuchi, H. and Wei, M. and Morimura, K. and Salim, E. I. and Fukushima, S.

    Cancer Lett   192 ( 1 )   37 - 47   2003

     More details

    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

  • Lack of a dose-response relationship for carcinogenicity in the rat liver with low doses of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline or N-nitrosodiethylamine Reviewed

    Fukushima, S. and Wanibuchi, H. and Morimura, K. and Wei, M. and Nakae, D. and Konishi, Y. and Tsuda, H. and Uehara, N. and Imaida, K. and Shirai, T. and Tatematsu, M. and Tsukamoto, T. and Hirose, M. and Furukawa, F. and Wakabayashi, K. and Totsuka, Y.

    Jpn J Cancer Res   93 ( 10 )   1076 - 1082   2002

     More details

    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

  • Carcinogenicity of dimethylarsinic acid in male F344 rats and genetic alterations in induced urinary bladder tumors Reviewed

    Wei, M. and Wanibuchi, H. and Morimura, K. and Iwai, S. and Yoshida, K. and Endo, G. and Nakae, D. and Fukushima, S.

    Carcinogenesis   23 ( 8 )   1387 - 1397   2002

     More details

    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

  • DNA damage repair in bladder urothelium after the Chernobyl accident in Ukraine Reviewed

    Romanenko, A. and Morimura, K. and Wei, M. and Zaparin, W. and Vozianov, A. and Fukushima, S.

    J Urol   168 ( 3 )   973 - 977   2002

     More details

    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

  • Food restriction inhibits the growth of intestinal polyps in multiple intestinal neoplasia mouse Reviewed

    Kakuni, M. and Morimura, K. and Wanibuchi, H. and Ogawa, M. and Wei, M. and Hayashi, S. and Fukushima, S.

    Jpn J Cancer Res   93 ( 3 )   236 - 241   2002

     More details

    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

  • Role of oxidative DNA damage caused by carbon tetrachloride-induced liver injury -- enhancement of MeIQ-induced glutathione S-transferase placental form-positive foci in rats Reviewed

    Iwai, S. and Karim, R. and Kitano, M. and Sukata, T. and Wei, M. and Morimura, K. and Wanibuchi, H. and Seki, S. and Fukushima, S.

    Cancer Lett   179 ( 1 )   15 - 24   2002

     More details

    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

  • Suppression of chemical carcinogenesis by water-soluble organosulfur compounds Reviewed

    Fukushima, S. and Takada, N. and Wanibuchi, H. and Hori, T. and Wei, M. and Ogawa, M.

    J Nutr   131 ( 3s )   1049S - 1053S   2001

     More details

    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

  • Presence of a no-observed effect level for enhancing effects of development of the alpha-isomer of benzene hexachloride (alpha-BHC) on diethylnitrosamine-initiated hepatic foci in rats Reviewed

    Masuda, C. and Wanibuchi, H. and Otori, K. and Wei, M. and Yamamoto, S. and Hiroi, T. and Imaoka, S. and Funae, Y. and Fukushima, S.

    Cancer Lett   163 ( 2 )   179 - 185   2001

     More details

    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

  • Possible prevention by abieslactone of development of diethylnitrosamine-initiated GST-P positive foci in the rat liver Reviewed

    Iwai, S. and Wei, M. and Morimura, K. and Wanibuchi, H. and Tanaka, R. and Matsunaga, S. and Yoshitake, A. and Seki, S. and Fukushima, S.

    Teratog Carcinog Mutagen   21 ( 3 )   223 - 229   2001

     More details

    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

  • p53 and H-ras mutations and microsatellite instability in renal pelvic carcinomas of NON / Shi mice treated with N-butyl-N-(4-hydroxybutyl)-nitrosamine: different genetic alteration from urinary bladder carcinoma Reviewed

    Gen, H. and Yamamoto, S. and Morimura, K. and Wei, M. and Mitsuhashi, M. and Murai, T. and Mori, S. and Hosono, M. and Oohara, T. and Makino, S. and Wanibuchi, H. and Fukushima, S.

    Jpn J Cancer Res   92 ( 12 )   1278 - 1283   2001

     More details

    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

  • Inhibition by ginseng of 1,2-dimethylhydrazine induction of aberrant crypt foci in the rat colon Reviewed

    Li, W. and Wanibuchi, H. and Salim, E. I. and Wei, M. and Yamamoto, S. and Nishino, H. and Fukushima, S.

    Nutr Cancer   36 ( 1 )   66 - 73   2000

     More details

    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

  • Chemopreventive effects of S-methylcysteine on rat hepatocarcinogenesis induced by concurrent administration of sodium nitrite and morpholine Reviewed

    Wei, M. and Wanibuchi, H. and Yamamoto, S. and Iwai, S. and Morimura, K. and Nomura, T. and Takayama, R. and Fukushima, S.

    Cancer Lett   161 ( 1 )   97 - 103   2000

     More details

    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

  • Concentration dependent promoting effects of sodium L-ascorbate with the same total dose in a rat two-stage urinary bladder carcinogenesis Reviewed

    Chen, T. X. and Wanibuchi, H. and Wei, M. and Morimura, K. and Yamamoto, S. and Hayashi, S. and Fukushima, S.

    Cancer Lett   146 ( 1 )   67 - 71   1999

     More details

    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

  • Enhancement of urinary bladder carcinogenesis in nullizygous p53-deficient mice by N-butyl-N-(4-hydroxybutyl)nitrosamine Reviewed

    Yamamoto, S. and Wei, M. and Lee, C. C. and Salim, E. I. and Wanibuchi, H. and Sukata, T. and Fukushima, S.

    Cancer Lett   135 ( 2 )   137 - 144   1999

     More details

    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

  • Specific p53 gene mutations in urinary bladder epithelium after the Chernobyl accident Reviewed

    Yamamoto, S. and Romanenko, A. and Wei, M. and Masuda, C. and Zaparin, W. and Vinnichenko, W. and Vozianov, A. and Lee, C. C. and Morimura, K. and Wanibuchi, H. and Tada, M. and Fukushima, S.

    Cancer Res   59 ( 15 )   3606 - 3609   1999

     More details

    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

  • Urinary bladder carcinogenicity of dimethylarsinic acid in male F344 rats Reviewed

    Wei, M. and Wanibuchi, H. and Yamamoto, S. and Li, W. and Fukushima, S.

    Carcinogenesis   20 ( 9 )   1873 - 1876   1999

     More details

    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

▼display all

Books and Other Publications

  • Atlas of Diagnositic Pathology of Tumors in Laboratory Animals International journal

    ( Role: Joint editor)

    2022.11  ( ISBN:978-7-03-073263-7

     More details

    Total pages:484  

MISC

  • 農薬の安全性評価ー現状と課題 Invited International journal

    魏民、鰐渕英機

    Foods & Food Ingredients Journal of Japan   228 ( 4 )   292 - 298   2023.10

     More details

    Authorship:Lead author, Corresponding author   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)   International / domestic magazine:Domestic journal  

  • 芳香族アミンばく露と職業性膀胱がん International journal

    鈴木周五、魏民、鰐渕英機

    Precision Medicine   6 ( 4 )   292 - 298   2023.04

     More details

    Publishing type:Article, review, commentary, editorial, etc. (scientific journal)   International / domestic magazine:Domestic journal  

  • 1,4-ジオキサンはin vivo変異原性陽性である その変異原性および発がん性の定量解析 Reviewed

    魏 民, 藤岡 正喜, 梯 アンナ, 奥野 高裕, 増村 健一, 能美 健彦, 松本 道治, 大森 雅子, 鰐渕 英機, 福島 昭治

    大阪市医学会雑誌   69   32 - 32   2020.12( ISSN:0386-4103

     More details

    Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 【環境因子と発がん】化学物質曝露による職業がんの発生要因とメカニズム 動物実験を基礎とした新たな職業性膀胱がん原因物質の発見

    鰐渕 英機, 魏 民, 鈴木 周五

    (株)羊土社 実験医学   38 ( 11 )   1842 - 1848   2020.07( ISSN:0288-5514

     More details

    Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

    職業に起因する発がん要因に曝露され生じるがんを職業がんといい、産業の発達とともに大きな問題となっている。職業性膀胱がんは主に染料産業に発生し、芳香族アミンが主な原因物質として報告されている。日本でも2019年にオルトトルイジンにさらされる業務による膀胱がんが、厚生労働省の「職業病リスト」に記載され、労災補償の対象となり話題となった。われわれは同工場で生産されていた新規芳香族アミンの発がん性およびそのメカニズムを、動物実験を介して解明した。ここでは、職業がんの歴史から発がん物質の検出法、動物実験モデルの有効性について解説したい。(著者抄録)

  • 【"ヒ素"とは何か】発がん物質としてのヒ素

    鈴木 周五, 魏 民, 鰐渕 英機

    (株)杏林書院 保健の科学   62 ( 6 )   374 - 379   2020.06( ISSN:0018-3342

     More details

    Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 加齢マウスへの亜鉛の長期間過剰投与による学習・記憶障害について

    吉田 香, 魏 民, 藤岡 正喜, 寺本 勲

    Biomedical Research on Trace Elements   30 ( 2 )   82 - 82   2019.06( ISSN:0916-717X ( eISSN:1880-1404

     More details

    Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 【泌尿器系疾患と慢性炎症】 ビルハルツ住血吸虫症と膀胱癌 Invited

    鰐渕 英機, 魏 民, 行松 直

    (株)北隆館 別冊Bio Clinica: 慢性炎症と疾患   7 ( 4 )   49 - 53   2018.12

     More details

    Publishing type:Article, review, commentary, editorial, etc. (scientific journal)   Kind of work:Joint Work  

    ビルハルツ住血吸虫症は、主に泌尿生殖器に感染する寄生虫疾患でありアフリカのほぼ全域、中南東、インドの西部、マダガスカル島などに分布する。ビルハルツ住血吸虫症は膀胱癌の発症と強く関連しており、膀胱癌発症までの潜伏期間は約30年で、その大部分が扁平上皮癌であり、膀胱癌発見時にその多くが浸潤性膀胱癌であることが特徴である。ビルハルツ住血吸虫感染における慢性炎症による酸化的ストレスがDNA傷害を引き起こし、がん関連遺伝子の発現異常、細胞増殖、前癌病変、癌化へと連続することが考えられる。(著者抄録)

  • 膀胱癌の実験モデルにおけるleucineとisoleucinの役割(Roles of Leucine and Isoleucine in Experimental Models of Bladder Carcinogenesis) Reviewed

    Gi Min, Wanibuchi Hideki

    内閣府食品安全委員会 Food Safety   3 ( 4 )   136 - 142   2015.12

     More details

    Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 化学発がん物質のリスク評価における閾値問題 Reviewed

    福島 昭治, 魏 民, 梯 アンナ, 鰐渕 英機

    (一社)日本毒性学会, The Journal of Toxicological Sciences   39 ( Suppl. )   S15 - S15   2014.07( ISSN:0388-1350

     More details

    Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 発がん物質にも閾値が存在する Reviewed

    福島 昭治, 魏 民, 梯 アンナ, 鰐渕 英機

    日本マイコトキシン学会, マイコトキシン   58 ( 2 )   119 - 128   2008.10( ISSN:0285-1466

     More details

    Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

    2-amino-3,8-dimethylimidazo[4,5-f] quinoxaline(MeIQx)は、魚や肉などの焼けこげに含まれている物質である。今回、MeIQxのラット肝臓における低用量発がん性を中期発がん性試験法にて検討した。その結果、MeIQx-DNA付加体形成は微量からみられた。より高い用量で8-hydroxy-2&#039;-deoxyquanosine形成、lacI遺伝子変異、イニシエーション活性等が誘発された。また、肝臓の前腫瘍性病変であるglutahione S-transferase placental(GST-P)陽性細胞巣は、更により高い用量で誘発された。N-ニトロソ化合物であるN-nitrosodiethylamineやN-nitrosodimethylamineでもGST-P陽性細胞巣の発生は微量では発生しなかった。更に、大腸発がん物質である2-amino-1methyl-6-phenylimidazo[4,5-b] pyridine(PhIP)のラット発がん性を検討した結果、大腸粘膜におけるPhIP-DNA付加体形成は微量から認められた。前腫瘍性病変の代替マーカーである変異クリプト巣は、高用量でのみ誘発された。非遺伝毒性肝発がん物質であるphenobarbitalは、GST-P陽性細胞巣の発生を高用量では増加させ、逆に低用量ではその発生を抑制した。以上の結果から、遺伝毒性発がん物質には閾値、少なくとも実際的な閾値が、また、非遺伝毒性発がん物質には真の閾値が存在することが示唆された。

    DOI: 10.2520/myco.58.119

    CiNii Article

  • 食品などに含まれる発がん物質に閾値が存在するのか Reviewed

    福島 昭治, 梯 アンナ, 魏 民, 鰐渕 英機

    (公社)日本食品衛生学会, 食品衛生学雑誌   49 ( 5 )   J - 314   2008.10( ISSN:0015-6426

     More details

    Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 【毒性病理学の最近の話題】 発がん物質には閾値が存在する Reviewed

    福島 昭治, 鰐渕 英機, 魏 民

    (株)文光堂, 病理と臨床   25 ( 8 )   751 - 756   2007.08( ISSN:0287-3745

     More details

    Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 食品に含まれる発がん物質には閾値がある Reviewed

    福島 昭治, 鰐渕 英機, 魏 民

    (NPO)国際生命科学研究機構, イルシー   ( 89 )   37 - 42   2007.05( ISSN:1347-3239

     More details

    Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

    食品中には多数の発がん物質が含まれていることが実験的に明らかになっている。一般に発がん物質、特に遺伝毒性発がん物質には閾値がないとされている。この理論上の無閾値論が正しいかどうかを検証すべく、食品に含まれる発がん物質の低用量発がん性をラット中期発がん検索法を用いて検討した。その結果、ヘテロサイクリックアミンである2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline(MeIQx)やN-ニトロソ化合物であるdiethylnitrosamineのラット肝発がん性に関して、MeIQx-DNA付加体形成、in vivo変異原性、前がん病変の発生など、種々のマーカーに作用しない量が存在し、またそれらの反応曲線から発がん閾値が存在すると結論づけることができた。(著者抄録)

  • 発がん性と遺伝毒性の閾値 リスクアセスメントにおける問題点 遺伝毒性発がん物質の閾値問題 微量でも本当に危険なのか Reviewed

    福島 昭治, 鰐渕 英機, 森村 圭一朗, 魏 民

    日本環境変異原学会, 環境変異原研究   27 ( 2 )   75 - 79   2005.07( ISSN:0910-0865

     More details

    Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

    DOI: 10.3123/jems.27.75

▼display all

Presentations

  • ジフェニルアルシン酸(DPAA)のラット妊娠期及び授乳期ばく露による次 世代に対する発達神経毒性の検討 Domestic conference

    Guiyu Qiu、魏民、藤岡正喜、鈴木周五、梯アンナ、山本与毅、野浦郁恵、ワチラアルンウオン アルパマス、郭潤傑、鰐渕英機

    第113回日本病理学会総会  2024.03 

     More details

    Presentation type:Poster presentation  

  • 肺大細胞神経内分泌癌の新規バイオマーカー候補の検討 Domestic conference

    野浦郁恵、鈴木周五、梯アンナ、魏民、藤岡正喜、ワチラアルンウオン アルパマス、井上健、鰐渕英機

    第113回日本病理学会総会  2024.03 

     More details

    Presentation type:Poster presentation  

  • NADPH酸化酵素阻害剤apocyninによるo-toluidine誘発ラット膀胱増殖性 病変への抑制効果 Domestic conference

    鈴木周五、魏民、藤岡正喜、Guiyu Qiu、Arpamas Vachiraarunwon、梯アンナ、鰐渕英機

    第113回日本病理学会総会  2024.03 

     More details

    Presentation type:Oral presentation (general)  

  • Toxicological Assessment of Dimethylarsinic Acid Using Humanized Liver Mice Model Domestic conference

    Arpamas Vachiraarunwon、魏民、藤岡正喜、鈴木周五、Guiyu Qiu、郭潤傑、梯アンナ、鰐渕英機

    第113回日本病理学会総会  2024.03 

     More details

    Presentation type:Poster presentation  

  • 不死化ヒト膀胱上皮細胞を用いた三次元膀胱培養モデルの確立及びそれを用 いたヒ素毒性評価 Domestic conference

    郭潤傑、魏民、ワチラアルンウオン アルパマス、藤岡正喜、鈴木周五、Guiyu Qiu、山本与毅、梯アンナ、鰐渕英機

    第113回日本病理学会総会  2024.03 

     More details

    Presentation type:Poster presentation  

  • ジメチルアルシン酸誘発ラット膀胱発がんにおけるDNAメチル化異常 Domestic conference

    魏民、山本与毅、鈴木周五、藤岡正喜、ワチラアルンウオン アルパマス、郭潤傑、Guiyu Qiu、梯アンナ、鰐渕英機

    第113回日本病理学会総会  2024.03 

     More details

    Presentation type:Poster presentation  

  • ヒト浸潤性膵管癌の新規バイオマーカー候補の解明 Domestic conference

    梯アンナ、西土井悠作、Guiyu Qiu、鈴木周五、藤岡正喜、魏民、鰐渕英機

    第113回日本病理学会総会  2024.03 

     More details

    Presentation type:Poster presentation  

  • ジフェニルアルシン酸の経胎盤曝露によるF1マウス肝発がん機序にはDNA メチル化異常が関与する Domestic conference

    藤岡正喜、魏民、鈴木周五、大石裕司、ワチラアルンウオン アルパマス、邱桂ギョク、芝野佳奈、梯アンナ、鰐渕英機

    第113回日本病理学会総会  2024.03 

     More details

    Presentation type:Poster presentation  

  • Toxicological Assessment of Dimethylarsinic Acid Using Humanized Liver Mice Model Domestic conference

    Arpamas Vachiraarunwon、魏民、藤岡正喜、鈴木周五、Guiyu Qiu、郭潤傑、梯アンナ、鰐渕英機

    第113回日本病理学会総会  2024.03 

     More details

    Presentation type:Poster presentation  

  • Diphenylarsinic acid induced transplacental liver carcinogenesis via epigenetic alterations in F1 mice Domestic conference

    藤岡正喜、魏民、鈴木周五、大石裕司、梯アンナ、鰐渕英機

    2023年度文部科学省 学術変革領域研究 学術研究支援基盤形成【先端モデル動物支援プラットフォーム】成果発表会  2024.02 

     More details

    Presentation type:Oral presentation (general)  

  • Evaluating hepatic metabolism and carcinogenicity of dimethylarsinic acid using humanized liver mice model Domestic conference

    Arpamas Vachiraarunwon, Min Gi, Masaki Fujioka, Shugo Suzki, Guiyu Qiu, Runjie Guo, Anna Kakehashi, Hideki Wanibuchu

    第40回日本毒性病理学会総会及び学術集会  2024.01 

     More details

    Presentation type:Symposium, workshop panel (public)  

  • Effect of diphenylarsinic acid on hippocampal neurogenesis in SD rats Domestic conference

    Guiyu Qiu, Min Gi, Masaki Fujioka, Shugo Suzuki, Anna Kakehashi, Tomoki Yamamoto, Ikue Noura, Arpamas Vachiraarunwon, Runjie Guo, Hideki Wanibuchi

    第40回日本毒性病理学会総会及び学術集会  2024.01 

     More details

    Presentation type:Poster presentation  

  • Development of a novel 3D urinary bladder mucosa model and evaluation of assessing arsenical toxicity Domestic conference

    Runjie Guo, Min Gi, Tohru Kiyono, Arpamas Vachiraarunwon, Masaki Fujioka, Shugo Suzuki, Guiyu Qiu, Tomoki Yamamoto, Anna Kakehashi, Hideki Wanibuchi

    第40回日本毒性病理学会総会及び学術集会  2024.01 

     More details

    Presentation type:Poster presentation  

  • Diphenylarsinic acid induced transplacental liver carcinogenesis via epigenetic changes in F1 mice Domestic conference

    Masaki Fujioka, Min Gi, Shugo Suzuki, Yuji Oishi, Arpamas Vachiraarunwon, Guiyu Qiu, Kana Shibano, Anna Kakehashi, Hideki Wanibuchi

    第40回日本毒性病理学会総会及び学術集会  2024.01 

     More details

    Presentation type:Poster presentation  

  • 化学物質のラット経気管肺内噴霧投与法のin vitro投与量設定法の開発 Domestic conference

    藤岡正喜、魏民、芝野佳奈、邱桂鈺、Vachiraarunwon Arpamas、郭潤傑、鈴木周五、鰐渕英機

    第50回産業中毒・生物学的モニタリング研究会  2023.11 

     More details

    Presentation type:Oral presentation (general)  

  • ヒト浸潤性膵管癌の新規バイオマーカー候補の検討 Domestic conference

    梯アンナ、西土井悠作、Guiyu Qiu、鈴木周五、藤岡正喜、ワチラルンウオン アルパマス、魏民、鰐渕英機

    第82回日本癌学会学術総会  2023.09 

     More details

    Presentation type:Poster presentation  

  • 有機ヒ素化合物ジフェニルアルシン酸経胎盤ばく露マウスにおける肝発がん過程にはDNAメチル化異常が関与する Domestic conference

    藤岡正喜、魏民、鈴木周五、大石裕司、ワチラルンウオン アルパマス、邱桂鈺、芝野佳奈、梯アンナ、鰐渕英機

    第82回日本癌学会学術総会  2023.09 

     More details

    Presentation type:Poster presentation  

  • Comparison of carcinogenicity of arsenicals on immortalized human bladder epithelial cells Domestic conference

    ワチラルンウオン アルパマス、魏民、鈴木周五、芝野佳奈、Qiu Guiya、郭潤傑、Pharapirom Aroonrat、梯アンナ、藤岡正喜、鰐渕英機

    第82回日本癌学会学術総会  2023.09 

     More details

    Presentation type:Poster presentation  

  • ジメチルアルシン酸の経胎盤ばく露による肝発がんに脂質代謝異常が関与する Domestic conference

    鈴木周五、魏民、藤岡正喜、梯アンナ、鰐渕英機

    第82回日本癌学会学術総会  2023.09 

     More details

    Presentation type:Poster presentation  

  • DMA誘発ラット膀胱発がんにおけるcarboxypeptidase XM1の役割の検討 Domestic conference

    山本与毅、魏民、鈴木周五、藤岡正喜、郭潤傑、邱桂鈺、ワチラルンウオン アルパマス、鰐渕英機

    第82回日本癌学会学術総会  2023.09 

     More details

    Presentation type:Poster presentation  

  • ヒト化肝臓マウスにおける無機ヒ素ばく露による尿中糞中代謝物の野生型動物との比較及び影響の検討 Domestic conference

    芝野佳奈、魏民、藤岡正喜、ワチラルンウオン アルパマス、鈴木周五、郭潤傑、邱桂鈺、鰐渕英機

    第82回日本癌学会学術総会  2023.09 

     More details

    Presentation type:Poster presentation  

  • Glutelin hydrolysate of purple rice bran exhibited cancer chemopreventive activity against liver and colon carcinogenesis International coauthorship Domestic conference

    Arpamas Vachiraarunwon, Aroonrat Pharapirom, Rawiwan Wongpoomchai, Min Gi, Shugo Suzuki, Annna Kakehashi, Masaki Fujioka, Hideki Wanibuchi

    がん予防学術大会2023金沢  2023.09 

     More details

    Presentation type:Poster presentation  

  • Apocyninによるo-toluidine誘発ラット膀胱増殖性病変への抑制効果 Domestic conference

    鈴木周五、魏民、藤岡正喜、邱桂鈺、郭潤傑、Vachiraarunwon Arpamas、梯アンナ、鰐渕英機

    がん予防学術大会2023金沢  2023.09 

     More details

    Presentation type:Poster presentation  

  • ジメチルアルシン酸誘発ラット膀胱がんにおけるDNAメチル化異常 Domestic conference

    山本与毅、魏民、山下聡、鈴木周五、藤岡正喜、郭潤傑、邱桂鈺、Vachiraarunwon Arpamas、鰐渕英機

    第36回発癌病理研究会  2023.08 

     More details

    Presentation type:Oral presentation (general)  

  • ヒト化肝臓マウスにおける無機ヒ素の体内動態および膀胱に及ぼす影響 Domestic conference

    魏民、藤岡正喜、鈴木周五、Arpamas Vachiraarunwon、Guiyu Qiu、芝野佳奈、鰐渕英機

    第96回日本産業衛生学会  2023.05 

     More details

    Presentation type:Oral presentation (general)  

  • ジメチルアルシン酸誘発ラット膀胱がんにおけるDNAメチル化異常 Domestic conference

    山本与毅、魏民、鈴木周五、藤岡正喜、Vachirarunwon Arpamas、Guiyu Qiu、芝野佳奈、清水一希、梯アンナ、鰐渕英機

    第39回日本毒性病理学会総会および学術集会  2023.01 

     More details

    Presentation type:Symposium, workshop panel (public)  

  • Toxicities of various arsenicals on immortalized normal human bladder epithelial cells. International coauthorship Domestic conference

    Arpamas Vachiraarunwong, Min Gi, Tohru Kiyono, Shugo Suzuki, Kana Shibano, Guiyu Qiu, Pharapirom Aroonrat, Anna Kakehashi, Masaki Fujioka, Hideki Wanibuchi

    第39回日本毒性病理学会総会および学術集会  2023.01 

     More details

    Presentation type:Symposium, workshop panel (public)  

    Venue:東京  

  • γH2AXとKi-67を用いた遺伝毒性肝発がん物質の早期検出:機械学習による自動判定の試み Domestic conference

    道場彩乃、魏民、櫻井映子、寺本篤司、桐山諭和、山田勢至、鰐渕英機、塚本徹哉

    第39回日本毒性病理学会総会および学術集会  2023.01 

     More details

    Presentation type:Symposium, workshop panel (public)  

    Venue:東京  

  • ヒト化肝臓マウスにおける無機ヒ素の体内動態及び毒性 International coauthorship Domestic conference

    芝野佳奈、魏民、藤岡正喜、Arpamas Vachirarunwon、Pharapirom Aroonrat、Guiyu Qiu、鈴木周五、鰐渕英機

    第39回日本毒性病理学会総会および学術集会  2023.01 

     More details

    Presentation type:Poster presentation  

    Venue:東京  

  • 業性ばく露を認めたo-toluidineの尿中代謝物による膀胱尿路上皮への影響 Domestic conference

    鈴木周五、魏民、藤岡正喜、梯アンナ、鰐渕英機

    第39回日本毒性病理学会総会および学術集会  2023.01 

     More details

    Presentation type:Poster presentation  

    Venue:東京  

  • ヒト浸潤性膵管癌の新規バイオマーカー候補の解析 Domestic conference

    梯アンナ、西土井悠作、Guiyu Qiu、鈴木周五、藤岡正喜、魏民、鰐渕英機

    第39回日本毒性病理学会総会および学術集会  2023.01 

     More details

    Presentation type:Poster presentation  

    Venue:東京  

  • マウス経胎盤曝露モデルにおけるジフェニルアルシン酸(DPAA)のエピジェネティック修飾異常を介した肝発がんの亢進 International coauthorship Domestic conference

    藤岡正喜、魏民、鈴木周五、芝野佳奈、Guiyu Qiu、Arpamas Vachirarunwon、Pharapirom Aroonrat、大石裕司、梯アンナ、鰐渕英機

    第39回日本毒性病理学会総会および学術集会  2023.01 

     More details

    Presentation type:Poster presentation  

    Venue:東京  

  • ジメチルアルシン酸による膀胱発がん機序の解明 Domestic conference

    鈴木周五、魏民、藤岡正喜、梯アンナ、鰐渕英機

    第27回ヒ素シンポジウム  2022.12 

     More details

    Presentation type:Symposium, workshop panel (public)  

    Venue:今治  

  • ヒ素誘発膀胱発がん過程におけるDNAメチル化異常の関与 Domestic conference

    魏民、藤岡正喜、鈴木周五、山本与毅、Vachirarunwon Arpamas、梯アンナ、鰐渕英機

    第27回ヒ素シンポジウム  2022.12 

     More details

    Presentation type:Symposium, workshop panel (public)  

    Venue:今治  

  • 無機ヒ素曝露ヒト肝マウスにおける尿中及び糞中ヒ素の化学形態別性状の解析 Domestic conference

    藤岡正喜、魏民、Vachirarunwon Arpamas、鈴木周五、鰐渕英機

    第27回ヒ素シンポジウム  2022.12 

     More details

    Presentation type:Symposium, workshop panel (public)  

    Venue:今治  

  • マウス経胎盤ばく露による有機ヒ素化合物の発がん性およびその機序 Domestic conference

    藤岡正喜、魏民、鈴木周五、大石裕司、梯アンナ、邱桂鈺、芝野佳奈、鰐渕英機

    第35回発癌病理研究会  2022.11 

     More details

    Presentation type:Oral presentation (general)  

    Venue:新潟  

  • マウス経胎盤曝露モデルにおけるジフェニルアルシン酸(DPAA)のエピジェネティック修飾異常を介した肝発がんの亢進 Domestic conference

    藤岡正喜、魏民、鈴木周五、大石裕司、邱桂鈺、梯アンナ、鰐渕英機

    第81回日本癌学会学術総会  2022.09 

     More details

    Presentation type:Poster presentation  

    Venue:横浜  

  • ジメチルアルシン酸誘発ラット膀胱発がんにおけるDNAメチル化異常

    魏民、鈴木周五、山下聡、藤岡正喜、梯アンナ、山本与毅、邱桂鈺、鰐渕英機

    第81回日本癌学会学術総会  2022.09 

     More details

    Presentation type:Poster presentation  

    Venue:横浜  

  • 芳香族アミンによる職業性膀胱がん Domestic conference

    鈴木周五、魏民、藤岡正喜、梯アンナ、鰐渕英機

    第81回日本癌学会学術総会  2022.09 

     More details

    Presentation type:Symposium, workshop panel (public)  

    Venue:横浜  

  • 職業性膀胱がん候補化学物質によるDNA付加体の網羅的解析

    帶金明日香、小宮雅美、鈴木周五、魏民、鰐渕英機、戸塚ゆ加里

    第81回日本癌学会学術総会  2022.09 

     More details

    Presentation type:Poster presentation  

    Venue:横浜  

  • 1,4-ジオキサンの肝発がん機序の解明と定量的発がんリスク評価 Domestic conference

    魏民、鈴木周五、藤岡正喜、梯アンナ、鰐渕英機

    第49回日本毒性学会学術年会  2022.07 

     More details

    Presentation type:Poster presentation  

    Venue:札幌  

  • 職業性ばく露を認めたo-toluidoneの尿中代謝物と膀胱尿路上皮への影響 Domestic conference

    鈴木周五、魏民、藤岡正喜、梯アンナ、鰐渕英機

    第49回日本毒性学会学術年会  2022.07 

     More details

    Presentation type:Poster presentation  

    Venue:札幌  

  • 職業性膀胱がん関連芳香族アミン類の尿中代謝物と膀胱尿路上皮への影響 Domestic conference

    鈴木周五、魏民、藤岡正喜、梯アンナ、鰐渕英機

    第111回日本病理学会総会  2022.04 

     More details

    Presentation type:Oral presentation (general)  

    Venue:神戸国際会議場  

  • 化審法に有用な新規化学物質の肝発がん性評価スキームの創出 Invited Domestic conference

    魏民, 鈴木周五, 藤岡正喜, 梯アンナ, 鰐渕英機

    第37回日本毒性病理学会総会及び学術集会  2021.01 

     More details

    Presentation type:Symposium, workshop panel (nominated)  

  • マウス肝発がんにおける新規マーカーとしてcanopy homolog 2の解明 Domestic conference

    梯アンナ, 鈴木周五, 藤岡正喜, 魏民, 鰐渕英機

    第37回日本毒性病理学会総会及び学術集会  2021.01 

     More details

    Presentation type:Poster presentation  

  • NADPH oxidase阻害剤apocyninによるニコチン誘発ラット膀胱増殖病変抑制効果 Domestic conference

    鈴木周五, 加藤寛之, 内木綾, 魏民, 鰐渕英機, 高橋智

    第37回日本毒性病理学会総会及び学術集会  2021.01 

     More details

    Presentation type:Poster presentation  

  • NASH肝発がんにおける特異候補分子および新規マーカーとしてのCACHD1の役割 Domestic conference

    梯アンナ, 鈴木周五, 魏民, 鰐渕英機

    第79回日本癌学会学術総会  2020.10 

     More details

    Presentation type:Poster presentation  

  • ラット膀胱尿路上皮のニコチンによる増殖はNADPH oxidase阻害剤apocyninにより抑制される Domestic conference

    鈴木周五, 加藤寛之, 内木綾, 魏民, 鰐渕英機, 高橋智

    第79回日本癌学会学術総会  2020.10 

     More details

    Presentation type:Poster presentation  

  • Aberrant histone H3K9 methylation in lung carcinogenesis induced by transplacental organic arsenical exposure in mice Domestic conference

    Gi Min, Suzuki Shugo, Kakehashi Anna, Matsue Taisuke, Wanibuchi Hideki

    第79回日本癌学会学術総会  2020.10 

     More details

    Presentation type:Poster presentation  

  • 職業曝露によるがん発生の要因解明と予防研究への展開 Invited Domestic conference

    鰐渕英機, 魏民

    第27回がん予防学会総会  2020.09 

     More details

    Presentation type:Symposium, workshop panel (nominated)  

  • ラットにおけるacetoaceto-o-toluidideの膀胱発がん促進作用 Domestic conference

    魏民, 行松直, 鈴木周五, 梯アンナ, 鰐渕英機

    第47回日本毒性学会学術年会  2020.06 

     More details

    Presentation type:Poster presentation  

  • 芳香族アミンacetoaceto-o-toluidideのラット膀胱発がん性とその機序解明 Domestic conference

    魏民, 鈴木周五, 行松直, 梯アンナ, 鰐渕英機

    第93回日本産業衛生学会  2020.06 

     More details

    Presentation type:Poster presentation  

  • ラットにおけるBBN誘発膀胱発がんに対するo-Acetoacetotoluidideの促進効果 Domestic conference

    行松 直, 魏 民, 梯 アンナ, 鈴木 周五, 鰐渕 英機

    第36回日本毒性病理学会 東京  2020.02 

  • ジフェニルアルシン酸のマウスにおける経胎盤発がん作用 Domestic conference

    魏 民, 鈴木 周五, 梯 アンナ, 山口貴嗣, 鰐渕 英機

    第36回日本毒性病理学会 東京  2020.02 

  • NASH肝臓発がんにおける新規マーカー候補分子の検討 Domestic conference

    梯 アンナ, 石井 直美, 魏 民, 鈴木 周五, 鰐渕 英機

    第36回日本毒性病理学会 東京  2020.02 

  • 1,4-ジオキサンはin vivo変異原性陽性である:その変異原性及び発がん性の定量解析 Domestic conference

    魏 民

    大阪市医学会第516回例会  2019.11 

  • ジフェニルアルシン酸の長期毒性及びその発現機序-動物試験から得られた知見- Domestic conference

    鰐渕英機, 魏民, 梯アンナ, 鈴木周五

    第23回ヒ素シンポジウム 群馬  2019.11 

  • Novel in vivo Bioassays for Prediction of Chemical Carcinogenicity Invited International conference

    Gi Min

    第3回中国薬学会毒性病理専門学術検討会 中国  2019.11 

  • 機能性食品の安全性評価 Invited Domestic conference

    魏民, 鰐渕英機

    日本食品化学学会第35回食品化学シンポジウム 東京  2019.11 

  • ジフェニルアルシン酸の胎仔期ばく露におけるマウス肝発がん性の検討 Domestic conference

    魏 民, 藤岡 正喜, 大石 裕司, 鈴木 周五, 梯 アンナ, 山口 貴嗣, 鰐渕 英機

    第78回日本癌学会学術総会 京都  2019.09  日本癌学会

  • 非アルコール性脂肪肝炎の肝臓癌におけるアルギニン及び糖代謝産物の蓄積 Domestic conference

    梯 アンナ, 石井 真美, 奥野 高裕, 魏 民, 鰐渕 英機

    第78回日本癌学会学術総会 京都  2019.09  日本癌学会

  • 発がん過程におけるゲノムと環境因子の相互作用 芳香族アミンによる職業性膀胱がんに関する最新知見 Domestic conference

    鰐渕 英機, 魏 民

    第78回日本癌学会学術総会 京都  2019.09  日本癌学会

  • ラットにおけるBBN誘発膀胱発がんに対するアセトアセト-o-トルイジドの促進効果 Domestic conference

    行松 直, 奥野 高裕, 魏 民, 梯 アンナ, 鰐渕 英機

    第78回日本癌学会学術総会 京都  2019.09  日本癌学会

  • Nicotineの膀胱発がん促進効果とその機序 Domestic conference

    鈴木周五, 加藤寛之, 内木綾, 魏民, 梯アンナ, 髙橋智, 鰐渕英機

    第34回発癌病理研究会 三重  2019.08 

  • 加齢マウスへの亜鉛の長期間過剰投与による学習・記憶障害について Domestic conference

    吉田 香, 魏 民, 藤岡 正喜, 寺本 勲

    第30回日本微量元素学会 長野  2019.07  日本微量元素学会

  • アフラトキシンB1はキメラ化したヒト化TK-NOGマウスのヒト肝領域を特異的に障害する Domestic conference

    奥野 高裕, 魏 民, 梯 アンナ, 末水 洋志, 秦 順一, 鰐渕 英機

    第46回日本毒性学会学術年会 徳島  2019.06  (一社)日本毒性学会

  • 発がん性評価法の最新の展望 In vivo発がん物質短・中期検出法の開発 Domestic conference

    鰐渕 英機, 魏 民

    第46回日本毒性学会学術年会 徳島  2019.06  (一社)日本毒性学会

  • Acetoaceto-o-toluidideはラット膀胱上皮の細胞増殖を促進し、発がん促進作用を示す Domestic conference

    奥野 高裕, 魏 民, 藤岡 正喜, 梯 アンナ, 鰐渕 英機

    第108回日本病理学会総会 東京  2019.05  (一社)日本病理学会

  • NASHモデルTSODマウスにおける肝臓腫瘍および肝臓のメタボローム解析(Metabolome analysis in the liver tumors and tissues of NASH model TSOD mice) Domestic conference

    梯 アンナ, 石井 直美, 奥野 高裕, 魏 民, 鰐渕 英機

    第108回日本病理学会総会 東京  2019.05  (一社)日本病理学会

  • BBN誘発マウス膀胱がんモデルにおけるAcetazolamideの予防効果の検討 Domestic conference

    魏 民, 藤岡 正喜, 行松 直, 奥野 高裕, 山口 貴嗣, 梯 アンナ, 鰐渕 英機

    日本毒性病理学会講演要旨集  2019.01  日本毒性病理学会

  • 有機ヒ素化合物ジメチルアルシニン酸に経胎盤曝露したマウスの肺癌発症におけるエピジェネティクス修飾の異常(Epigenetic modification abnormality in lung carcinogenesis in mice transplacental exposure of organic arsenic compound Dimethylarsinic acid) Domestic conference

    Fujioka Masaki, Gi Min, Okuno Takahiro, Yukimatsu Nao, Kakehashi Anna, Oishi Yuji, Wanibuchi Hideki

    日本毒性病理学会講演要旨集  2019.01  日本毒性病理学会

  • 有機ヒ素化合物Dimethylarsinic acidの経胎盤ばく露によるマウス肺発がん過程におけるヒストン修飾異常 Domestic conference

    藤岡 正喜, 魏 民, 奥野 高裕, 行松 直, 梯 アンナ, 大石 裕司, 鰐渕 英機

    日本毒性病理学会講演要旨集  2019.01  日本毒性病理学会

  • マウス膀胱の発癌に関するアセタゾラミドの阻害効果の評価(Evaluation of inhibitory effects of acetazolamide on the mouse bladder carcinogenesis) Domestic conference

    Gi Min, Fujioka Masaki, Yukimatsu Nao, Okuno Takahiro, Yamaguchi Takashi, Kakehashi Anna, Wanibuchi Hideki

    日本毒性病理学会講演要旨集  2019.01  日本毒性病理学会

  • ジフェニルアルシン酸のF344ラットにおける慢性毒性試験及び発がん性試験 Domestic conference

    山口 貴嗣, 魏 民, 藤岡 正喜, 梯 アンナ, 鰐渕 英機

    日本毒性病理学会講演要旨集  2019.01  日本毒性病理学会

  • o-Acetoacetotoluidideの膀胱に対する毒性と発癌促進作用に関する研究(Study on toxicity and carcinogenic promoting effect to bladder of o-Acetoacetotoluidide) Domestic conference

    Yukimatsu Nao, Okuno Takahiro, Gi Min, Fujioka Masaki, Kakehashi Anna, Wanibuchi Hideki

    日本毒性病理学会講演要旨集  2019.01  日本毒性病理学会

  • o-Acetoacetotoluidideによる膀胱に対する毒性、発がんプロモーション作用の検討 Domestic conference

    行松 直, 奥野 高裕, 魏 民, 藤岡 正喜, 梯 アンナ, 鰐渕 英機

    日本毒性病理学会講演要旨集  2019.01  日本毒性病理学会

  • NASHモデルTSODマウスの肝腫瘍と組織のメタボローム解析(Metabolome analysis in the liver tumors and tissues of NASH model TSOD mice) Domestic conference

    Kakehashi Anna, Ishii Naomi, Okuno Takahiro, Tago Yoshiyuki, Fujioka Masaki, Gi Min, Wanibuchi Hideki

    日本毒性病理学会講演要旨集  2019.01  日本毒性病理学会

  • F344系ラットにおけるdiphenylarsic acidの慢性的毒性と発癌性に関する研究(Chronic toxicity and carcinogenicity study of diphenylarsinic acid in F344 rat) Domestic conference

    Yamaguchi Takashi, Gi Min, Fujioka Masaki, Kakehashi Anna, Wanibuchi Hideki

    日本毒性病理学会講演要旨集  2019.01  日本毒性病理学会

  • Ogg1ミュータントマウスにおけるフェノバルビタール投与による肝細胞腺腫から癌への進行 Domestic conference

    梯 アンナ, 石井 真美, 奥野 高裕, 藤岡 正喜, 魏 民, 福島 昭治, 鰐渕 英機

    大阪市医学会雑誌  2018.12  大阪市医学会

     More details

    Presentation type:Oral presentation (general)  

  • Acetoaceto-o-toluidideはラット膀胱上皮細胞の増殖とDNA傷害を誘発する(Induction of cell proliferation and DNA damage by Acetoaceto-o-toluidide in the urinary bladder of rats) Domestic conference

    奥野 高裕, 行松 直, 藤岡 正喜, 梯 アンナ, 魏 民, 神吉 将之, 鰐渕 英機

    日本癌学会総会記事  2018.09  日本癌学会

     More details

    Presentation type:Oral presentation (general)  

  • 有機ヒ素化合物Dimethylarsinic acidのマウス経胎盤ばく露による発がん機序の検討(Study of the mechanism of carcinogenesis by prenatal exposure to dimethylarsinic acid in mice) Domestic conference

    藤岡 正喜, 魏 民, 奥野 高裕, 行松 直, 大石 裕司, 梯 アンナ, 鰐渕 英機

    日本癌学会総会記事  2018.09  日本癌学会

     More details

    Presentation type:Oral presentation (general)  

  • ラットにおける1,4-dioxaneの変異原性と発がん性の定量的解析(In vivo positive mutagenicity of 1,4-dioxane and quantitative analysis of its mutagenicity and carcinogenicity in rats) Domestic conference

    魏 民, 藤岡 正喜, 奥野 高裕, 行松 直, 山口 貴嗣, 梯 アンナ, 鰐渕 英機

    日本癌学会総会記事  2018.09  日本癌学会

     More details

    Presentation type:Oral presentation (general)  

  • メタボリックシンドロームモデルTSODマウスにおけるNASH肝臓組織及び腫瘍のメタボローム解析(Metabolome changes in NASH liver tissue and tumors developed in metabolic syndrome model TSOD mice) Domestic conference

    梯 アンナ, 石井 真美, 奥野 高裕, 藤岡 正喜, 多胡 善幸, 魏 民, 鰐渕 英機

    日本癌学会総会記事  2018.09  日本癌学会

     More details

    Presentation type:Oral presentation (general)  

  • 非アルコール性脂肪肝炎(NASH)の肝組織と肝がんにおけるプロテオーム解析(Proteomics of Non-Alcoholic Steatohepatitis Liver Tissue and Associated Hepatocellular Carcinomas) Domestic conference

    梯 アンナ, 石井 真美, 奥野 高裕, 魏 民, 鰐渕 英機

    日本病理学会会誌  2018.04  (一社)日本病理学会

     More details

    Presentation type:Oral presentation (general)  

  • 細胞障害の制御とその破綻による病態発生 環境化学物質による発がんと細胞傷害・修復の破綻 Domestic conference

    鰐渕 英機, 魏 民, 藤岡 正喜, 梯 アンナ, 奥野 高裕

    日本病理学会会誌  2018.04  (一社)日本病理学会

     More details

    Presentation type:Oral presentation (general)  

  • NASH由来の肝細胞癌におけるmTORの活性化 Domestic conference

    奥野 高裕, 石井 真美, 梯 アンナ, 魏 民, 鰐渕 英機

    日本病理学会会誌  2018.04  (一社)日本病理学会

     More details

    Presentation type:Oral presentation (general)  

  • マウス経胎盤ばく露による有機ヒ素化合物Dimethylarsinic acidの発がん性およびその機序 Domestic conference

    熊田賢次、藤岡正喜、魏民、大石裕司、奥野高裕、梯アンナ、鰐渕英機

    第17回分子予防環境医学研究会  2018.02  分子予防環境医学研究会

     More details

    Presentation type:Oral presentation (general)  

    Venue:三重大学附属病院(津市)  

  • O-Acetoacetoluidide(AAOT)の毒性影響の検討 Domestic conference

    熊田賢次、奥野高裕、魏 民、藤岡正喜、行松 直、梯アンナ、鰐渕英機

    第34回日本毒性病理学会総会及び学術集会  2018.01  日本毒性病理学会

     More details

    Presentation type:Poster presentation  

    Venue:沖縄かりゆしアーバンリゾート・ナハ(那覇市)  

  • 遺伝毒性肝発がん物質超短期検出法の開発 Domestic conference

    魏 民、藤岡正喜、梯アンナ、鰐渕英機

    第34回日本毒性病理学会総会及び学術集会  2018.01  日本毒性病理学会

     More details

    Presentation type:Symposium, workshop panel (nominated)  

    Venue:沖縄かりゆしアーバンリゾート・ナハ(那覇市)  

  • 2つのNASHモデルマウスにおける病理組織学的所見の違い Domestic conference

    奥野高裕、石井真美、梯アンナ、藤岡正喜、魏 民、鰐渕英機

    第34回日本毒性病理学会総会及び学術集会  2018.01  日本毒性病理学会

     More details

    Presentation type:Symposium, workshop panel (public)  

    Venue:沖縄かりゆしアーバンリゾート・ナハ(那覇市)  

  • マウス経胎盤ばく露による有機ヒ素化合物Dimethylarsinic acidの発がん性およびその機序 Domestic conference

    藤岡正喜、魏 民、奥野高裕、熊田賢次、梯アンナ、大石裕司、鰐渕英機

    第34回日本毒性病理学会総会及び学術集会  2018.01  日本毒性病理学会

     More details

    Presentation type:Oral presentation (general)  

    Venue:沖縄かりゆしアーバンリゾート・ナハ(那覇市)  

  • NASHの肝臓組織や肝臓癌におけるプロテオーム解析 Domestic conference

    梯アンナ、奥野高裕、藤岡正喜、魏 民、鰐渕英機

    第34回日本毒性病理学会総会及び学術集会  2018.01  日本毒性病理学会

     More details

    Presentation type:Poster presentation  

    Venue:沖縄かりゆしアーバンリゾート・ナハ(那覇市)  

  • NASHの肝臓組織や肝臓癌におけるプロテオーム解析 Domestic conference

    梯 アンナ, 奥野 高裕, 藤岡 正喜, 魏 民, 鰐渕 英機

    日本毒性病理学会講演要旨集  2018.01  日本毒性病理学会

     More details

    Presentation type:Oral presentation (general)  

  • 発がんリスク評価法 遺伝毒性肝発がん物質超短期検出法の開発 Domestic conference

    魏 民, 藤岡 正喜, 梯 アンナ, 鰐渕 英機

    日本毒性病理学会講演要旨集  2018.01  日本毒性病理学会

     More details

    Presentation type:Oral presentation (general)  

  • マウス経胎盤ばく露による有機ヒ素化合物Dimethylarsinic acidの発がん性およびその機序 Domestic conference

    藤岡 正喜, 魏 民, 奥野 高裕, 熊田 賢次, 梯 アンナ, 大石 裕司, 鰐渕 英機

    日本毒性病理学会講演要旨集  2018.01  日本毒性病理学会

     More details

    Presentation type:Oral presentation (general)  

  • o-Acetoacetotoluidide(AAOT)の毒性影響の検討 Domestic conference

    熊田 賢次, 奥野 高裕, 魏 民, 藤岡 正喜, 行松 直, 梯 アンナ, 鰐渕 英機

    日本毒性病理学会講演要旨集  2018.01  日本毒性病理学会

     More details

    Presentation type:Oral presentation (general)  

  • NASHモデルの病態と機序 2つのNASHモデルマウスにおける病理組織学的所見の違い Domestic conference

    奥野 高裕, 石井 真美, 梯 アンナ, 藤岡 正喜, 魏 民, 鰐渕 英機

    日本毒性病理学会講演要旨集  2018.01  日本毒性病理学会

     More details

    Presentation type:Oral presentation (general)  

  • マウス経胎盤ばく露による有機ヒ素化合物Dimethylarsinic acidの発がん性およびその機序 Domestic conference

    藤岡正喜、魏 民、奥野高裕、熊田賢次、梯アンナ、大石裕司、鰐渕英機

    第23回ヒ素シンポジウム  2017.12  日本ヒ素研究会

     More details

    Presentation type:Oral presentation (general)  

    Venue:つくばイノベーションプラザ(つくば市)  

  • 非アルコール性脂肪肝炎の肝臓組織や肝臓癌におけるプロテオーム解析 Domestic conference

    梯アンナ、石井真美、藤岡正喜、魏 民、鰐渕英機

    第76回日本癌学会学術総会  2017.09  日本癌学会

     More details

    Presentation type:Poster presentation  

    Venue:パシフィコ横浜(横浜市)  

  • BBN誘発マウス膀胱がんにおけるInk4a/Arfの役割の検討 Domestic conference

    香山侑弘、魏 民、藤岡正喜、熊田賢次、奥野高裕、梯アンナ、鰐渕英機

    第76回日本癌学会学術総会  2017.09  日本癌学会

     More details

    Presentation type:Poster presentation  

    Venue:パシフィコ横浜(横浜市)  

  • BBN誘発マウス膀胱発がんモデルにおけるAcetazolamideの抑制効果の検討 Domestic conference

    魏 民、藤岡正喜、梯アンナ、奥野高裕、香山侑弘、熊田賢次、鰐渕英機

    第76回日本癌学会学術総会  2017.09  日本癌学会

     More details

    Presentation type:Poster presentation  

    Venue:パシフィコ横浜(横浜市)  

  • CD1マウスにおけるジメチルアルシン酸(DMA)の胎児期ばく露による発がん性 Domestic conference

    藤岡正喜、魏 民、熊田賢次、奥野高裕、梯アンナ、鰐渕英機

    第76回日本癌学会学術総会  2017.09  日本癌学会

     More details

    Presentation type:Poster presentation  

    Venue:パシフィコ横浜(横浜市)  

  • NASHモデルマウスを用いた肝細胞癌の発がんメカニズム解析 Domestic conference

    奥野高裕、梯アンナ、石井真美、藤岡正喜、魏 民、鰐渕英機

    文部科学省新学術領域研究 学術研究支援基盤形成 先端モデル動物支援プラットフォーム若手支援技術講習会  2017.09 

     More details

    Presentation type:Oral presentation (general)  

    Venue:蓼科グランドホテル滝の湯(長野県)  

  • マウス経胎盤ばく露による有機ヒ素化合物DMAの発がん性 Domestic conference

    藤岡正喜、魏 民、奥野高裕、梯アンナ、鰐渕英機

    文部科学省新学術領域研究 学術研究支援基盤形成 先端モデル動物支援プラットフォーム若手支援技術講習会  2017.09 

     More details

    Presentation type:Oral presentation (general)  

    Venue:蓼科グランドホテル滝の湯(長野県  

  • 非アルコール性脂肪肝炎の肝臓組織や肝臓癌におけるプロテオーム解析 Domestic conference

    梯 アンナ, 石井 真美, 藤岡 正喜, 魏 民, 鰐渕 英機

    日本癌学会総会記事  2017.09  日本癌学会

     More details

    Presentation type:Oral presentation (general)  

  • CD1マウスにおけるジメチルアルシン酸(DMA)の胎児期ばく露による発がん性 Domestic conference

    藤岡 正喜, 魏 民, 熊田 賢次, 奥野 高裕, 梯 アンナ, 鰐渕 英機

    日本癌学会総会記事  2017.09  日本癌学会

     More details

    Presentation type:Oral presentation (general)  

  • BBN誘発マウス膀胱がんにおけるInk4a/Arfの役割の検討 Domestic conference

    香山 侑弘, 魏 民, 藤岡 正喜, 熊田 賢次, 奥野 高裕, 梯 アンナ, 鰐淵 英機

    日本癌学会総会記事  2017.09  日本癌学会

     More details

    Presentation type:Oral presentation (general)  

  • NASHモデルマウスを用いた肝細胞癌の発がんメカニズム解析 Domestic conference

    奥野高裕、梯アンナ、石井真美、藤岡正喜、魏 民、鰐渕英機

    第32回発癌病理研究会  2017.08 

     More details

    Presentation type:Oral presentation (general)  

    Venue:琵琶湖ホテル(大津市)  

  • 1,2-ジクロロプロパンおよびジクロロメタン複合曝露によるマウス肝臓への影響 Domestic conference

    藤岡正喜、魏 民、河内聡子、梯アンナ、鰐渕英機

    第44回日本毒性学会学術年会  2017.07  (一社)日本毒性学会

     More details

    Presentation type:Poster presentation  

    Venue:パシフィコ横浜(横浜市)  

  • ヒ素の発がんリスク評価 Invited Domestic conference

    鰐渕英機、魏 民、藤岡正喜、梯アンナ

    第44回日本毒性学会学術年会  2017.07  (一社)日本毒性学会

     More details

    Presentation type:Symposium, workshop panel (nominated)  

    Venue:パシフィコ横浜(横浜市)  

  • 環境中の微量元素の毒性学 ヒ素の発がんリスク評価 Domestic conference

    鰐渕 英機, 魏 民, 藤岡 正喜, 梯 アンナ

    The Journal of Toxicological Sciences  2017.06  (一社)日本毒性学会

     More details

    Presentation type:Oral presentation (general)  

  • 1,2-ジクロロプロパンおよびジクロロメタン複合曝露によるマウス肝臓への影響(Carcinogenic effects of concurrent administration of 1,2-dichloropropane and dichloromethane in mice) Domestic conference

    藤岡 正喜, 魏 民, 河内 聡子, 梯 アンナ, 鰐渕 英機

    The Journal of Toxicological Sciences  2017.06  (一社)日本毒性学会

  • 腎細胞癌のマウスモデルにおいて抗PD-L1療法はeverolimusの抗腫瘍効果を増強する(Anti-PD-L1 treatment promotes antitumor effect of everolimus in a mouse model of renal cell carcinoma) Domestic conference

    Hirayama Yukiyoshi, Gi Min, Tamada Satoshi, Wanibuchi Hideki, Nakatani Tatsuya

    日本泌尿器科学会総会  2017.04  (一社)日本泌尿器科学会総会事務局

  • 環境発がん 環境がおよぼす細胞・組織・臓器・個体レベルでの病理学的変化 実験的アプローチを用いたヒ素発がん性の証明とその機序の解明 Domestic conference

    鰐渕 英機, 魏 民

    日本病理学会会誌  2017.03  (一社)日本病理学会

     More details

    Presentation type:Oral presentation (general)  

  • 有機砒素化合物Dimethylarsinic acid誘発ラット膀胱発がんに対する抗酸化物質Apocyninの化学予防効果 Domestic conference

    土井 賢一郎, 熊田 賢次, 魏 民, 奥野 高裕, 武下 正憲, 鰐渕 英機

    日本病理学会会誌  2017.03  (一社)日本病理学会

     More details

    Presentation type:Oral presentation (general)  

  • 1,2-ジクロロプロパンおよびジクロロメタン複合暴露におけるマウス肝発がん影響 Domestic conference

    河内 聡子, 魏 民, 藤岡 正喜, 辰己 久美子, 多胡 善幸, 梯 アンナ, 鰐渕 英機

    日本毒性病理学会講演要旨集  2017.01  日本毒性病理学会

     More details

    Presentation type:Oral presentation (general)  

  • Dimethylarsinic acid誘発ラット膀胱発がんに対するNADPH oxidase阻害剤Apocyninの抑制効果 Domestic conference

    熊田 賢次, 土井 賢一郎, 藤岡 正喜, 魏 民, 武下 正憲, 鰐渕 英機

    日本毒性病理学会講演要旨集  2017.01  日本毒性病理学会

     More details

    Presentation type:Oral presentation (general)  

  • 1,2-DCPおよびDCM複合曝露がマウス肝発がんを促進する Domestic conference

    河内 聡子, 魏 民, 藤岡 正喜, 辰己 久美子, 梯 アンナ, 土井 賢一郎, 鰐渕 英機

    日本癌学会総会記事  2016.10  日本癌学会

     More details

    Presentation type:Oral presentation (general)  

  • 遺伝毒性の逆襲 遺伝毒性試験から発がん性と発がんリスクを予測する 遺伝毒性・発がん性をスクリーニングするin vivo短期検索法 Domestic conference

    鰐渕 英機, 藤岡 正喜, 魏 民

    The Journal of Toxicological Sciences  2016.06  (一社)日本毒性学会

     More details

    Presentation type:Oral presentation (general)  

  • 亜鉛の長期間過剰摂取が加齢マウスの学習・記憶能に及ぼす影響について Domestic conference

    吉田 香, 魏 民, 山野 荘太郎, 木俣 勲

    Biomedical Research on Trace Elements  2016.06  日本微量元素学会

     More details

    Presentation type:Oral presentation (general)  

  • 短期間に後腹膜絨毛癌の肺転移により出血死した壮年男性の剖検例 Domestic conference

    土井 賢一郎, 石井 真美, 武貞 博治, 山本 朋納, 魏 民, 梯 アンナ, 鰐渕 英機

    日本病理学会会誌  2016.04  (一社)日本病理学会

     More details

    Presentation type:Oral presentation (general)  

  • ダンマル樹脂のF344ラットを用いたがん原性試験 ダンマル樹脂はラット肝発がん物質である Domestic conference

    魏 民, 山野 荘太郎, 藤岡 正喜, 梯 アンナ, 立花 大和, 土井 賢一郎, 鰐渕 英機

    日本癌学会総会記事  2015.10  日本癌学会

     More details

    Presentation type:Oral presentation (general)  

  • ラットにおける2-エトキシ-2-メチルプロパンの肝臓発腫瘍性機序の解明 Domestic conference

    梯 アンナ, 萩原 昭裕, 今井 則夫, 魏 民, 福島 昭治, 鰐渕 英機

    The Journal of Toxicological Sciences  2015.06  (一社)日本毒性学会

  • 紫外線に誘発される突然変異においてDNAポリメラーゼ・イータとイオタが皮膚細胞と組織で果たす役割(Roles of DNA polymerases eta and iota in UV-induced mutagenesis of skin cells and tissues) Domestic conference

    櫻井 靖高, 横井 雅幸, 塚本 徹哉, 魏 民, 鰐渕 英機

    日本病理学会会誌  2015.03  (一社)日本病理学会

     More details

    Presentation type:Oral presentation (general)  

  • 非遺伝毒性肝発がん物質ダンマル樹脂の発がんメカニズムの検討 Domestic conference

    藤岡 正喜, 魏 民, 山野 荘太郎, 下村 衣里, 三島 胡桃, 鰐渕 英機

    日本毒性病理学会講演要旨集  2015.01  日本毒性病理学会

     More details

    Presentation type:Oral presentation (general)  

  • 肝細胞癌における新規分子マーカーとしてCNPY2およびCACHD1の同定 Domestic conference

    梯 アンナ, 石井 真美, 魏 民, 藤岡 正喜, 鰐渕 英機

    日本毒性病理学会講演要旨集  2015.01  日本毒性病理学会

     More details

    Presentation type:Oral presentation (general)  

  • 紫外線照射DNAの損傷乗り越え複製においてDNAポリメラーゼイータとイオタが果たす生理的役割(Physiological roles of DNA polymerases η and ι in translesion synthesis past UV-induced DNA damage) Domestic conference

    櫻井 靖高, 横井 雅幸, 塚本 徹哉, 小田 司, 魏 民, 山下 孝之, 鰐渕 英機, 立松 正衛, 村雲 芳樹, 花岡 文雄

    日本癌学会総会記事  2014.09  日本癌学会

     More details

    Presentation type:Oral presentation (general)  

  • 環境発がんのリスク評価における病理学の貢献 ヒ素の発がん機構の解明 Domestic conference

    鰐渕 英機, 魏 民

    日本病理学会会誌  2014.09  (一社)日本病理学会

     More details

    Presentation type:Oral presentation (general)  

  • 実験動物福祉および実験動物モデルの新たな展開 国際動向を探る 遺伝子改変動物モデルの毒性評価への応用 Domestic conference

    鰐渕 英機, 魏 民

    The Journal of Toxicological Sciences  2014.07  (一社)日本毒性学会

     More details

    Presentation type:Oral presentation (general)  

  • 化学発がん物質のリスク評価における閾値問題 Domestic conference

    福島 昭治, 魏 民, 梯 アンナ, 鰐渕 英機

    The Journal of Toxicological Sciences  2014.07  (一社)日本毒性学会

     More details

    Presentation type:Oral presentation (general)  

  • 肝発がんにおけるLC-Ms/Ms及びin vitro機能解析を用いた新規特異的候補分子の検討 Domestic conference

    梯 アンナ, 石井 真美, 藤岡 正喜, 魏 民, 鰐渕 英機

    日本毒性病理学会講演要旨集  2014.01  日本毒性病理学会

     More details

    Presentation type:Oral presentation (general)  

  • 肺腺癌におけるPTRF/Cavin-1発現と予後との関連(Expression of PTRF/Cavin-1 is associated with poor prognosis of lung adenocarcinoma) Domestic conference

    井上 英俊, 魏 民, 小松 弘明, 山野 荘太郎, 梯 アンナ, 西山 典利, 鰐渕 英機

    日本癌学会総会記事  2013.10  日本癌学会

     More details

    Presentation type:Oral presentation (general)  

  • 内因性NADPHオキシダーゼインヒビターであるアポサイニンはラット腎発がんにおいて発がん抑制作用を有する(NADPH oxidase inhibitor apocynin has chemopreventive effect in EHEN-induced rat renal carcinogenesis) Domestic conference

    山野 荘太郎, 魏 民, 藤岡 正喜, 多胡 善幸, 北野 光昭, 三島 胡桃, 鰐渕 英機

    日本癌学会総会記事  2013.10  日本癌学会

     More details

    Presentation type:Oral presentation (general)  

  • 1,2-ジクロロプロパンのマウスおよびハムスターの肝臓における代謝および毒性発現機序の検討(Evaluation of the metabolic basis of hepatotoxicity of 1,2- dichloropropane in male B6C3F1 mice and Syrian hamsters) Domestic conference

    魏 民, 山野 荘太郎, 藤岡 正喜, 加藤 実, 武下 正憲, 梯 アンナ, 鰐渕 英機

    日本癌学会総会記事  2013.10  日本癌学会

     More details

    Presentation type:Oral presentation (general)  

  • gpt deltaラットにおける2-AAFによるin vivo変異原性および癌原性の検討(Examination of in vivo mutagenicity and carcinogenicity in the gpt delta rat with 2-AAF) Domestic conference

    Okumura Mai, Wei Min, Yamano Shotaro, Fujioka Masaki, Tago Yoshiyuki, Kitano Mitsuaki, Wanibuchi Hideki

    Journal of Toxicologic Pathology  2013.06  日本毒性病理学会

     More details

    Presentation type:Oral presentation (general)  

  • ラットにおける化学物質の膀胱癌原性を予測するためのmicroRNAマーカーの同定(Identification of MicroRNA Markers for Predicting Bladder Carcinogenicity of Chemicals in Rats) Domestic conference

    Gi Min, Yamano Shotaro, Kato Minoru, Fujioka Masaki, Kinoshita Anna, Kanki Masayuki, Wanibuchi Hideki

    Journal of Toxicologic Pathology  2013.06  日本毒性病理学会

  • ラット膀胱発癌物質DMA(V)のin vivo変異原性の検討(Examination of in vivo mutagenicity of rat bladder carcinogen DMA(V)) Domestic conference

    Fujioka Masaki, Wei Min, Yamano Shotaro, Okabe Kyoko, Fukunaga Satoki, Xie Xiaoli, Wanibuchi Hideki

    Journal of Toxicologic Pathology  2013.06  日本毒性病理学会

     More details

    Presentation type:Oral presentation (general)  

  • ラット肝臓におけるethyl tertiary-butyl etherの発癌性の作用機序 CAR、PXRおよびPPARの活性化を介する酸化ストレス誘導の証拠(Mode of action of ethyl tertiary-butyl ether tumorigenicity in the rat liver: Evidence for oxidative stress induction via activation of CAR, PXR and PPARs) Domestic conference

    Kakehashi Anna, Hagiwara Akihiro, Imai Norio, Wei Min, Nagano Kasuke, Fukushima Shoji, Wanibuchi Hideki

    Journal of Toxicologic Pathology  2013.06  日本毒性病理学会

     More details

    Presentation type:Oral presentation (general)  

  • マウス肺癌発生におけるAT1受容体阻害薬ロサルタンの修飾作用(Modifying effect of ATI receptor blocker Losartan in mice lung carcinogenesis) Domestic conference

    Okabe Kyoko, Yamano Shotaro, Wei Min, Fujioka Masaki, Xie Xiaoli, Kushida Masahiko, Wanibuchi Hideki

    Journal of Toxicologic Pathology  2013.06  日本毒性病理学会

     More details

    Presentation type:Oral presentation (general)  

  • マウス肺SCCにおける気管支肺胞幹細胞のcancer initiating cellとしての可能性(Possibility of Cancer Initiating Cell of Bronchiolar Alveolar Stem Cell for Mice Lung SCC) Domestic conference

    Yamano Shotaro, Wei Min, Fujioka Masaki, Kakehashi Anna, Wanibuchi Hideki

    Journal of Toxicologic Pathology  2013.06  日本毒性病理学会

     More details

    Presentation type:Oral presentation (general)  

  • 原発性肺腺癌組織におけるNapsin Aの発現と予後の相関 Domestic conference

    井上 英俊, 西山 典利, 魏 民, 梯 アンナ, 花田 庄司, 小松 弘明, 鰐渕 英機

    日本病理学会会誌  2013.04  (一社)日本病理学会

     More details

    Presentation type:Oral presentation (general)  

  • 膀胱発がん物質の早期検出microRNAマーカーの検討 Domestic conference

    魏 民, 山野 荘太郎, 加藤 実, 藤岡 正喜, 梯 アンナ, 神吉 将之, 鰐渕 英機

    日本毒性病理学会講演要旨集  2013.01  日本毒性病理学会

     More details

    Presentation type:Oral presentation (general)  

  • BBN誘発マウス膀胱発がん過程における幹細胞関連タンパク質の発現(Expressions of cancer stem cell-related proteins in BBN-induced mouse bladder carcinogenesis) Domestic conference

    魏 民, 山野 荘太郎, 加藤 実, 梯 アンナ, 神吉 将之, 謝 暁利, 鰐渕 英機

    日本癌学会総会記事  2012.08  日本癌学会

     More details

    Presentation type:Oral presentation (general)  

  • 癌のゲノム医療 チェルノブイリ原発事故後の長期低用量放射線暴露による膀胱病変とその発生メカニズム Domestic conference

    梯 アンナ, Romanenko Alina, 森村 圭一朗, 魏 民, 鰐渕 英機, 福島 昭治

    日本泌尿器科学会雑誌  2012.03  (一社)日本泌尿器科学会

     More details

    Presentation type:Oral presentation (general)  

  • 毒性病理を基盤としたメカニズム研究 ヒトプロト型c-Ha-rasトランスジェニックラットを用いた浸潤性膀胱がんモデルの開発と新規浸潤因子の同定 Domestic conference

    魏 民

    日本毒性病理学会講演要旨集  2012.02  日本毒性病理学会

     More details

    Presentation type:Oral presentation (general)  

  • 肺扁平上皮癌におけるプロテオーム解析と臨床病理学的検討(Proteome analysis and clinicopathologic examination in human lung squamous cell carcinoma) Domestic conference

    花田 庄司, 西山 典利, 山野 荘太郎, 小松 弘明, 丁 奎光, 梯 アンナ, 魏 民, 鰐渕 英機

    日本癌学会総会記事  2011.09  日本癌学会

     More details

    Presentation type:Oral presentation (general)  

  • 肺大細胞神経内分泌癌(LCNEC)の新たなバイオマーカーの同定(Identification of novel biomarkers of human lung large cell neuroendocrine carcinoma) Domestic conference

    小松 弘明, 西山 典利, 山野 荘太郎, 花田 庄司, 丁 奎光, 梯 アンナ, 魏 民, 鰐渕 英機

    日本癌学会総会記事  2011.09  日本癌学会

     More details

    Presentation type:Oral presentation (general)  

  • 環境因子の発がんへのインパクトの未来像 ヒ素ばく露と発がんリスク 動物モデルを用いた発がん機序の解明(Environmental arsenic exposure and cancer risk: Understanding arsenic carcinogenicity by the use of animal models) Domestic conference

    鰐渕 英機, 魏 民

    日本癌学会総会記事  2011.09  日本癌学会

     More details

    Presentation type:Oral presentation (general)  

  • 肺扁平上皮癌モデルにおける気管支肺胞幹細胞の役割 Domestic conference

    山野 荘太郎, 魏 民, 鰐渕 英機

    The Journal of Toxicological Sciences  2011.06  (一社)日本毒性学会

     More details

    Presentation type:Oral presentation (general)  

  • ハザードからリスク評価へ 遺伝毒性の新たなる前進 遺伝毒性発がん物質における閾値の存在 Domestic conference

    魏 民, 梯 アンナ, 福島 昭治, 鰐渕 英機

    The Journal of Toxicological Sciences  2011.06  (一社)日本毒性学会

  • 肺扁平上皮癌におけるプロテオーム解析と臨床病理学的検討 Domestic conference

    花田 庄司, 魏 民, 丁 奎光, 梯 アンナ, 西山 典利, 鰐渕 英機

    日本病理学会会誌  2011.03  (一社)日本病理学会

     More details

    Presentation type:Oral presentation (general)  

  • 膀胱がん新規浸潤因子Carbonic anhydrase 2の同定 Domestic conference

    魏 民, 山野 荘太郎, 加藤 実, 梯 アンナ, 鰐渕 英機

    日本病理学会会誌  2011.03  (一社)日本病理学会

     More details

    Presentation type:Oral presentation (general)  

  • 水素水によるTAA誘発ラット肝線維化の抑制効果 Domestic conference

    多胡 善幸, 仲谷 和記, 魏 民, 山田 貴宣, 太田 成男, 中島 裕司, 鰐渕 英機

    日本毒性病理学会講演要旨集  2011.01  日本毒性病理学会

     More details

    Presentation type:Oral presentation (general)  

  • 新規野菜ラファノブラシカによるピロリ菌誘発胃炎の抑制 Domestic conference

    山田 貴宣, 魏 民, 豊田 武士, 金川 明裕, 仲谷 慎也, 星 学, 鰐渕 英機

    日本毒性病理学会講演要旨集  2011.01  日本毒性病理学会

     More details

    Presentation type:Oral presentation (general)  

  • 質量分析に基づいた肺扁平上皮癌のプロテオーム特性(Mass spectrometry-based proteomic profiling of primary squamous cell lung carcinoma) Domestic conference

    花田 庄司, 梯 アンナ, 山野 荘太郎, 丁 奎光, 魏 民, 西山 典利, 鰐淵 英機

    日本癌学会総会記事  2010.08  日本癌学会

     More details

    Presentation type:Oral presentation (general)  

  • 自然発症2型糖尿病モデルラットの単離糸球体を用いたプロテオーム解析 Domestic conference

    仲谷 慎也, 石村 栄治, 石井 真美, 山野 荘太郎, 梯 アンナ, 魏 民, 森 克仁, 西沢 良記, 鰐渕 英機

    日本腎臓学会誌  2010.05  (一社)日本腎臓学会

     More details

    Presentation type:Oral presentation (general)  

  • 2型糖尿病モデルラットの糸球体を用いたプロテオーム解析 Domestic conference

    仲谷 慎也, 石井 真美, 山野 荘太郎, 梯 アンナ, 魏 民, 鰐渕 英機

    日本毒性病理学会講演要旨集  2010.02  日本毒性病理学会

     More details

    Presentation type:Oral presentation (general)  

  • 膀胱尿路上皮におけるdimethylmonothioarsinic acidの影響 Domestic conference

    菅 直人, 金川 明裕, 山田 貴宣, 吉田 香, 圓藤 吟史, 魏 民, 鰐渕 英機

    日本毒性病理学会講演要旨集  2010.02  日本毒性病理学会

     More details

    Presentation type:Oral presentation (general)  

  • ジメチルアルシン酸の代謝経路の解明 Domestic conference

    金川 明裕, 菅 直人, 吉田 香, 圓藤 吟史, 森 聖, 魏 民, 鰐渕 英機

    日本毒性病理学会講演要旨集  2010.02  日本毒性病理学会

     More details

    Presentation type:Oral presentation (general)  

  • 2型糖尿病自然発症ラットを用いた糖尿病の発がんに及ぼす影響の検討 Domestic conference

    石井 真美, 魏 民, 梯 アンナ, 山野 荘太郎, 仲谷 慎也, 鰐渕 英機

    日本毒性病理学会講演要旨集  2010.02  日本毒性病理学会

     More details

    Presentation type:Oral presentation (general)  

  • ヒト浸潤性膵管癌におけるPRDX3の機能解明 Domestic conference

    Guiyu Qiu、梯アンナ、鈴木周五、藤岡正喜、魏民、Arpamas Vachirarunwon、Pharapirom Aroonrat、芝野佳奈、鰐渕英機

    第39回日本毒性病理学会総会および学術集会 

     More details

    Presentation type:Poster presentation  

    Venue:東京  

▼display all

Grant-in-Aid for Scientific Research

  • 職業性膀胱がんの予防に資する短期尿路上皮発がんスクリーニングシステムの開発

    Grant-in-Aid for Scientific Research(C)  2023

  • 新規RING型E3によるSkp2プロテオスタシス制御の破綻と発がん機構の解明

    Grant-in-Aid for Scientific Research(C)  2023

  • 新規RING型E3によるSkp2プロテオスタシス制御の破綻と発がん機構の解明

    Grant-in-Aid for Scientific Research(C)  2022

  • 中高年のサプリメント摂取によって起こるミネラル過剰摂取が老人性認知症に及ぼす影響

    Grant-in-Aid for Scientific Research(C)  2022

  • 中高年のサプリメント摂取によって起こるミネラル過剰摂取が老人性認知症に及ぼす影響

    Grant-in-Aid for Scientific Research(C)  2020.04

  • 新規発がん超早期関連因子OCMを基軸とした尿路上皮癌発症機構の解明

    Grant-in-Aid for Scientific Research(C)  2018.04

  • 微量元素の組み合わせ過剰摂取と高脂肪食が老人性神経障害に及ぼす影響

    Grant-in-Aid for Scientific Research(C)  2017.04

  • Effects of excessive intake of trace elements and westernized high-fat diet on senile dementia

    Grant-in-Aid for Scientific Research(C)  2014.04

  • Study of mechanism of carcinogenesis by 1,2-dichloropropane using animal experiment model

    Grant-in-Aid for Scientific Research(C)  2014.04

  • Inhibitory effects of carbonic anhydrase 2 inhibitor on the invasion of urinary bladder cancer

    Grant-in-Aid for Scientific Research(C)  2013.04

  • Investigation of Mechanism of Action of Steroid Sulfatase in Bladder Cancer

    Grant-in-Aid for Scientific Research(C)  2012.04

  • The study of prevention of carcinogenesis by the selective scavenger of hydroxy radical species

    Grant-in-Aid for Scientific Research(C)  2011

  • Effects of excessive intake of trace elements on senile neuropathy and the development of a method for biological monitoring of trace elements

    Grant-in-Aid for Scientific Research(C)  2011

  • Alteration of microRNA expression and its role in bladder carcinogenesis

    Grant-in-Aid for Young Scientists(B)  2009

  • Effect of excessive intake of trace elements caused by taking dietary supplements on senile neuropathy

    Grant-in-Aid for Scientific Research(C)  2008

  • ELUCID ATION OF MECHANISMS OF URIN ARY BLADDER CARCINOMAS ASSOCIATED WITH SCHISTOSOMIASIS IN EGYPT

    Grant-in-Aid for Scientific Research(B)  2004

  • EVALUATION OF ARSENIC-INDUCED OXIDATIVE DNA DAMAGE AND ELUCIDATION OF MECHANISM OF ARSENIC CARCINOGENESIS

    Grant-in-Aid for Scientific Research(B)  2003

▼display all

Joint research

  • 毒物又は劇物の指定等に係る急性吸入毒性試験の代替法の開発及びその精緻化 に関する研究

    国立医薬品食品衛生研究所  厚生労働科学研究費補助金  2023.04

  • 毒物又は劇物の指定等に係る急性吸入毒性試験の代替法の開発及びその精緻化 に関する研究

    国立医薬品食品衛生研究所  厚生労働科学研究費補助金  2022.04

Contract research

  • 無機ヒ素のヒト体内での健康 影響発現メカニズムに関する研究

    内閣府食品安全委員会事務局  食品健康影響評価技術研究  2022

  • Effects of excessive combined intake of trace elements and westernized high-fat diet on senile dementia

    Japan Society for the Promotion of Science  2017.04

  • Study of mechanism of carcinogenesis by 1,2-dichloropropane using animal experiment model

    Japan Society for the Promotion of Science  2014.04

  • Effects of excessive intake of trace elements and westernized high-fat diet on senile dementia

    Japan Society for the Promotion of Science  2014.04

  • Inhibitory effects of carbonic anhydrase 2 inhibitor on the invasion of urinary bladder cancer

    Japan Society for the Promotion of Science  2013.04

  • Investigation of Mechanism of Action of Steroid Sulfatase in Bladder Cancer

    Japan Society for the Promotion of Science  2012.04

  • Effects of excessive intake of trace elements on senile neuropathy and the development of a method for biological monitoring of trace elements

    Japan Society for the Promotion of Science  2011

  • The study of prevention of carcinogenesis by the selective scavenger of hydroxy radical species

    Japan Society for the Promotion of Science  2011

  • Alteration of microRNA expression and its role in bladder carcinogenesis

    Japan Society for the Promotion of Science  2009

  • Effect of excessive intake of trace elements caused by taking dietary supplements on senile neuropathy

    Japan Society for the Promotion of Science  2008

  • ELUCID ATION OF MECHANISMS OF URIN ARY BLADDER CARCINOMAS ASSOCIATED WITH SCHISTOSOMIASIS IN EGYPT

    Japan Society for the Promotion of Science  2004

▼display all

Incentive donations / subsidies

  • 食品添加物の安全性評価のためのヒ素発がん機序の解明

    日本食品化学研究振興財団  2016.04

Other subsidies, etc.

  • 毒物又は劇物の指定等に係る急性吸入毒性試験の代替法の開発及び その精緻化に関する研究

    厚生労働省  化学物質リスク研究事業  2022.04

  • 化審法における監視化学物質・優先評価化学物質の長期毒性評価スキームの創出に関する研究

    厚生労働省  化学物質リスク研究事業  2022.04

  • 化審法における監視化学物質・優先評価化学物質の長期毒性評価スキームの創出に関する研究

    厚生労働省  2020.04

  • 気管内投与による化学物質の有害作用と発がん性の効率的評価手法の開発に関する研究

    厚生労働省  2019.04

  • 化学物質の有害性評価の迅速化・高度化・標準化に関する研究

    厚生労働省  2017.04

Acceptance of Researcher

  • 2023  Number of researchers:1

Outline of education staff

  • 人体病理学
    実験病理学

Charge of on-campus class subject

  • 病因と病態1コース

    2022     Undergraduate

  • 人体を考える

    2022   Weekly class   Undergraduate

  • 病理学

    2019     Undergraduate

  • 人体を考える

    2019     Undergraduate

  • 病理学

    2018     Undergraduate

  • 医学研究概論

    2018     Graduate school

▼display all

Faculty development activities

  • FD講習会  2023

  • FD講習会  2022

Number of papers published by graduate students

  • 2023

    Number of undergraduate student / college student presentations:Number of graduate students presentations:1

Number of instructed thesis, researches

  • 2023

    Number of instructed the graduation thesis:

    [Number of instructed the Master's Program] (previous term):[Number of instructed the Master's Program] (letter term):2

    [Number of master's thesis reviews] (chief):[Number of master's thesis reviews] (vice-chief):0

    [Number of doctoral thesis reviews] (chief):[Number of doctoral thesis reviews] (vice-chief):0

  • 2022

    Number of instructed the graduation thesis:

    [Number of instructed the Master's Program] (previous term):[Number of instructed the Master's Program] (letter term):2

Social Activities

  • 住友化学株式会社 「ヒト生命科学研究倫理審査委員会委員」

    Role(s): Investigater

    2022.04 - Now

     More details

    Audience: Company

    Type:Investigation, survey

  • 日本毒性学会基礎教育講習会

    Role(s): Lecturer

    日本毒性学会  2022.04 - Now

     More details

    Type:Certification seminar

Foreigner acceptance

  • 2023

    foreigners accepted :0

    International Students :2

  • 2022

    foreigners accepted :1

    International Students :1

International exchange activities

  • 日本毒性病理学会 第3回日中共同教育セミナー(日本東京)

    Field category :Education

    Country name :中国   2024.01

  • 日本毒性病理学会 第2回日中共同教育セミナー(中国上海)

    Field category :Education

    Country name :中国   2023.10

  • アジア毒性病理学会連盟 事務局長

    Field category :Education

    Country name :中国、韓国、インド   2021.12 - Now

Other

  • Job Career

    2011.04 - Now

  • Job Career

    2007.04 - 2011.03

  • Job Career

    2001.04 - 2007.03